BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P61964 (334 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5M25-A nrPDB 646 0.0 2H9P-A nrPDB 635 0.0 1VYH-C nrPDB 186 1e-47 5MZH-A nrPDB 185 2e-47 5NNZ-B nrPDB 179 1e-45 6QX9-5O nrPDB 169 2e-42 6CHG-A nrPDB 160 8e-40 6BX3-A nrPDB 158 3e-39 6Q8F-A nrPDB 147 6e-36 6F3T-A nrPDB 144 4e-35 6ID0-T nrPDB 140 1e-33 5FL8-q nrPDB 136 1e-32 6QX9-4B nrPDB 134 4e-32 5OPT-p nrPDB 134 5e-32 3JB9-g nrPDB 132 3e-31 5Y88-O nrPDB 131 4e-31 5YZG-W nrPDB 128 3e-30 6QDV-o nrPDB 128 4e-30 4V8M-A7 nrPDB 127 5e-30 6MZM-G nrPDB 127 9e-30 3JB9-L nrPDB 126 2e-29 5WYJ-BC nrPDB 125 4e-29 6HQA-B nrPDB 122 2e-28 4V6W-Ag nrPDB 115 2e-26 6G51-g nrPDB 113 9e-26 5K1B-B nrPDB 108 5e-24 6EOJ-D nrPDB 107 5e-24 5Z56-q nrPDB 107 9e-24 4LG8-A nrPDB 106 1e-23 3DM0-A nrPDB 105 2e-23 6GMH-W nrPDB 105 3e-23 5UZ7-B nrPDB 105 3e-23 5I2T-A nrPDB 104 6e-23 5GAN-H nrPDB 104 6e-23 5WLC-LO nrPDB 103 7e-23 6HHQ-h nrPDB 103 1e-22 5WYK-BB nrPDB 102 2e-22 3MKQ-A nrPDB 100 7e-22 2YNP-A nrPDB 100 1e-21 6N9G-C nrPDB 99 3e-21 5G04-R nrPDB 98 6e-21 4GGA-A nrPDB 96 2e-20 5LCW-Q nrPDB 96 2e-20 4N14-A nrPDB 94 6e-20 5NZU-C nrPDB 93 2e-19 3FM0-A nrPDB 93 2e-19 4BTS-AR nrPDB 92 4e-19 5FVM-C nrPDB 92 4e-19 5OQL-L nrPDB 89 2e-18 6J6H-n nrPDB 89 2e-18 4V7E-Bg nrPDB 87 1e-17 6EMK-B nrPDB 87 1e-17 3JAP-g nrPDB 84 6e-17 4J0W-A nrPDB 84 1e-16 2HES-X nrPDB 84 1e-16 5XYI-g nrPDB 81 6e-16 5OQL-J nrPDB 79 4e-15 5WBU-D nrPDB 78 4e-15 5L9T-R nrPDB 77 2e-14 3ODT-A nrPDB 76 2e-14 5OQL-X nrPDB 75 4e-14 4AEZ-A nrPDB 74 6e-14 1NR0-A nrPDB 71 6e-13 2AQ5-A nrPDB 70 1e-12 5WYJ-BE nrPDB 70 2e-12 5K0Y-T nrPDB 69 4e-12 4U1E-I nrPDB 68 7e-12 4A11-B nrPDB 67 1e-11 5OV3-A nrPDB 66 2e-11 3ACP-A nrPDB 65 5e-11 1PI6-A nrPDB 64 8e-11 6ELZ-p nrPDB 63 1e-10 4XYI-A nrPDB 63 2e-10 4YCZ-A nrPDB 62 3e-10 4BH6-A nrPDB 60 1e-09 5A31-R nrPDB 60 1e-09 3CFV-B nrPDB 59 2e-09 5MWJ-A nrPDB 59 3e-09 3C9C-A nrPDB 59 4e-09 5WJC-A nrPDB 59 4e-09 5WLC-LJ nrPDB 59 4e-09 4OWR-A nrPDB 58 5e-09 5Y1U-A nrPDB 58 5e-09 5OQL-d nrPDB 58 7e-09 6BX3-B nrPDB 55 6e-08 3JB9-S nrPDB 54 8e-08 5BJS-A nrPDB 54 1e-07 5WLC-LU nrPDB 53 2e-07 5CXC-A nrPDB 53 2e-07 4XFV-A nrPDB 53 2e-07 3JRP-A nrPDB 53 2e-07 4BZK-B nrPDB 52 3e-07 3JZG-A nrPDB 52 4e-07 4G56-B nrPDB 52 4e-07 6E29-D nrPDB 52 5e-07 4L9O-A nrPDB 51 7e-07 5N4A-A nrPDB 51 7e-07 5K19-A nrPDB 50 1e-06 5YZG-2 nrPDB 50 2e-06 3JRO-A nrPDB 49 2e-06 3W15-A nrPDB 49 3e-06 2PM9-A nrPDB 49 4e-06 5FA5-B nrPDB 48 7e-06 5MC6-j nrPDB 45 4e-05 5WLC-LW nrPDB 44 7e-05 4E5Z-B nrPDB 44 1e-04 5LTD-A nrPDB 44 1e-04 6EM1-m nrPDB 41 7e-04 6CB1-s nrPDB 41 8e-04 6C0F-s nrPDB 41 0.001 6CHG-D nrPDB 40 0.001 3BG0-A nrPDB 39 0.003 6IYY-A nrPDB 39 0.003 5WLC-SG nrPDB 39 0.003 4J0X-A nrPDB 39 0.003 5A9Q-7 nrPDB 38 0.006 5AJA-A nrPDB 38 0.007 4PSX-B nrPDB 37 0.008 5CXB-B nrPDB 37 0.010 5WLC-LN nrPDB 37 0.011 4AV8-A nrPDB 37 0.011 5A9Q-0 nrPDB 37 0.013 5M89-A nrPDB 36 0.026 6CVZ-A nrPDB 35 0.042 2VDU-B nrPDB 35 0.052 5A9Q-2 nrPDB 34 0.071 5WLC-LL nrPDB 32 0.42 5AMS-A nrPDB 32 0.44 6F1U-h nrPDB 32 0.50 6N8P-A nrPDB 32 0.55 2P9P-C nrPDB 31 0.60 5HX2-D nrPDB 31 0.69 3F3P-A nrPDB 31 0.70 5TF2-A nrPDB 30 1.0 6BN7-A nrPDB 30 1.6 1FLG-A nrPDB 30 1.9 5WLC-LS nrPDB 29 2.3 5JN2-A nrPDB 29 2.4 3MA6-A nrPDB 29 2.7 1MG2-A nrPDB 29 3.5 3EI3-B nrPDB 29 3.6 4TLV-A nrPDB 28 3.8 1Y6Z-A nrPDB 28 4.4 5WLC-LH nrPDB 28 5.9 2I3T-A nrPDB 28 6.0 3DWL-C nrPDB 28 6.8 5L8S-A nrPDB 27 8.4 4UHN-A nrPDB 27 8.4 >5M25-A nrPDB Length = 434 Score = 646 bits (1667), Expect = 0.0, Method: Compositional matrix adjust. Identities = 317/324 (97%), Positives = 317/324 (97%), Gaps = 2/324 (0%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK 70 EA R Q SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK Sbjct: 113 EAHREQI--GGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK 170 Query: 71 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN Sbjct: 171 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 230 Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS Sbjct: 231 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 290 Query: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 250 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK Sbjct: 291 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 350 Query: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH Sbjct: 351 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 410 Query: 311 PTENIIASAALENDKTIKLWKSDC 334 PTENIIASAALENDKTIKLWKSDC Sbjct: 411 PTENIIASAALENDKTIKLWKSDC 434 >2H9P-A nrPDB Length = 329 Score = 635 bits (1638), Expect = 0.0, Method: Compositional matrix adjust. Identities = 311/312 (99%), Positives = 311/312 (99%) Query: 23 ATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT 82 TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT Sbjct: 18 GTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT 77 Query: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN Sbjct: 78 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 137 Query: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS Sbjct: 138 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 197 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI Sbjct: 198 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 257 Query: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE Sbjct: 258 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 317 Query: 323 NDKTIKLWKSDC 334 NDKTIKLWKSDC Sbjct: 318 NDKTIKLWKSDC 329 >1VYH-C nrPDB Length = 410 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 100/319 (31%), Positives = 167/319 (52%), Gaps = 26/319 (8%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 P K+ L+GH V+ V F P + S+S D IK+W G FE+T+ GH + D Sbjct: 96 PRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQD 155 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 +++ LL S S D T+K+WD +C++T+ GH + V + P + IVS S D++ Sbjct: 156 ISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKT 215 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 +++W+V+TG C+KT H + V V N+DG+LI S S D R+W A+ +C K + + Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC-KAELRE 274 Query: 213 DNPPVSFVKFSPN--------------------GKYILAATLDNTLKLWDYSKGKCLKTY 252 V + ++P G ++L+ + D T+K+WD S G CL T Sbjct: 275 HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334 Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 GH N + + +GGK+I+S ++D + +W+ + K ++ L H V S H T Sbjct: 335 VGHDNWVRGVLFH---SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKT 391 Query: 313 ENIIASAALENDKTIKLWK 331 + + ++ D+T+K+W+ Sbjct: 392 APYVVTGSV--DQTVKVWE 408 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 36/103 (34%), Positives = 62/103 (60%) Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 G +L S S DK IK+W G T+ GH + V + S ++S +DDKTL++WD Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367 Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 + +C+KTL H ++V +F+ + +V+GS D++V++W+ + Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 >5MZH-A nrPDB Length = 452 Score = 185 bits (470), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 102/295 (34%), Positives = 160/295 (54%), Gaps = 7/295 (2%) Query: 39 FTLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 FTL GH V ++ F+ P G+ + + S DK K+W AY G+ T+ GH+ I ++++ Sbjct: 130 FTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP 189 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 S ++ + S D T K+WDV +G+ TL GH + FN +LIV+GSFD R+WD Sbjct: 190 QSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWD 249 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 V+TG+C+ L H VS+ FN G+L+VS S D R+WD SG+CL ++ V Sbjct: 250 VRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCL-SVKQGHTDEV 308 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 V F G +++A+ D + +L+ G C T GH+ E + N G +++ Sbjct: 309 LDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFN---PQGTRLITA 365 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 S D +W+ T E +Q L+GHTD + S A + + I + + D T ++WK+ Sbjct: 366 SSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGS--KDNTCRIWKA 418 Score = 178 bits (452), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 89/254 (35%), Positives = 143/254 (56%), Gaps = 4/254 (1%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 L +TL GH + + F+P +A+ S D K+W G+ T++GH+ I + ++ Sbjct: 171 LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFN 230 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + +L+V+ S D ++WDV +G+C+ L GH V FN L+VSGS D + R+W Sbjct: 231 TGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLW 290 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 DV++G+CL H+D V V F+ G+ +VS+S DG R++ T +G C TL+ + Sbjct: 291 DVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEG-E 349 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 +S V F+P G ++ A+ D T +LWD G+CL+ GH +E + N+ G +I++ Sbjct: 350 ISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYE---GDFIIT 406 Query: 277 GSEDNLVYIWNLQT 290 GS+DN IW T Sbjct: 407 GSKDNTCRIWKALT 420 Score = 171 bits (433), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 97/301 (32%), Positives = 161/301 (53%), Gaps = 7/301 (2%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 ++ L L H +++ F+ +G+ + S D+ K+W + G+ T+ GHK + + Sbjct: 83 SFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAI 142 Query: 94 AWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 A+++ + +V+ S DKT K+WD +G+ TLKGH + C +FNPQS +I +GS D + Sbjct: 143 AFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNT 202 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 ++WDV+TG+ TL H + ++ FN G LIV+ S+D R+WD +GQC+ L Sbjct: 203 AKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVL-SG 261 Query: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 VS +F+ G +++ ++D T +LWD G+CL GH +E + F G K Sbjct: 262 HRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDE--VLDVAFDAAGTK 319 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 +VS S D +++ T L GH + A +P + +A+ +DKT +LW Sbjct: 320 -MVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITAS--SDKTCRLWDC 376 Query: 333 D 333 D Sbjct: 377 D 377 >5NNZ-B nrPDB Length = 415 Score = 179 bits (454), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 100/293 (34%), Positives = 161/293 (54%), Gaps = 7/293 (2%) Query: 40 TLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 TL GH V ++ F+ P G+ +A+ S DK K+W GK T GH I ++++ Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 S L+ + S D T K+WD+ +G+ + TL+GHS + +FN + I++GSFD +V +WD Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 TG+ + L H +S+ FN D SLI++ S D C++WD +G+C+ TL D+ + Sbjct: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 F GK I A+ D T +++ + KC+ GH+ E I N G +++GS Sbjct: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 D IW+ QT + +Q L+GHTD + S A + NI+ + + D T ++W+ Sbjct: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIWR 415 Score = 168 bits (425), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 97/332 (29%), Positives = 175/332 (52%), Gaps = 18/332 (5%) Query: 11 EAARAQPTPSSSATQSKPTPVKP-----------NYALKFTLAGHTKAVSSVKFSPNGEW 59 E +A+P ++S T+ ++ + L L H +++V + +G Sbjct: 47 EIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSC 106 Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSS 118 + S D+ K+W G+ T+ GH+ + +A+++ + + + S DKT K+W V + Sbjct: 107 FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET 166 Query: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 178 GKC T +GH+ + C +FNPQS L+ +GS D + ++WD++ G+ + TL HS + ++ Sbjct: 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLS 226 Query: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 FN G I++ S+D +WD +G+ + LI +S F+ + IL ++D T Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILI-GHCAEISSASFNWDCSLILTGSMDKTC 285 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 KLWD + GKC+ T TGH +E + + F T GK I + S D I++ T++ + KL+ Sbjct: 286 KLWDATNGKCVATLTGHDDE--ILDSCFDYT-GKLIATASADGTARIFSAATRKCIAKLE 342 Query: 299 GHTDVVISTACHPTENIIASAALENDKTIKLW 330 GH + + +P N + + + +DKT ++W Sbjct: 343 GHEGEISKISFNPQGNHLLTGS--SDKTARIW 372 Score = 131 bits (329), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 72/229 (31%), Positives = 120/229 (52%), Gaps = 5/229 (2%) Query: 17 PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72 P + AT S T K N +TL GH+ + S+ F+ +G+ + + S D + +W Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246 Query: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132 A G+ + GH IS +++ D +L+++ S DKT K+WD ++GKC+ TL GH + + Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 F+ LI + S D + RI+ T KC+ L H +S + FN G+ +++ S D Sbjct: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 RIWD +GQCL+ L + + F+ G ++ + DNT ++W Sbjct: 367 KTARIWDAQTGQCLQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 58/170 (34%), Positives = 88/170 (51%), Gaps = 5/170 (2%) Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 K L AH P++ V N+ GS ++ SYD C++WDTASG+ L TL N + + Sbjct: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144 Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 P G I + D T KLW GKC T+ GH E C+ N T + +GS D Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST---LVATGSMDTTA 201 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 +W++Q E V L+GH+ +IS + + + + I + + D T+ +W +D Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDAD 249 >6QX9-5O nrPDB Length = 357 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%) Query: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71 A + Q TP + Q+ P A L+GH V KF PNG LAS+ D+LI + Sbjct: 34 AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92 Query: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 W Y D T+ GH + ++ +++D ++L SAS DKT+ +WD +G+ +K LKGH++ Sbjct: 93 WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152 Query: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 +V C PQ L+ +GS D +V++WD++ ++T ++ V AV FN I+ Sbjct: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII 209 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244 S D ++WD + T+ + V+ + S G Y+L+ +DNT+++WD Sbjct: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268 Query: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301 K +C+K + G H EK + ++S G K I +GS D VY+W+ ++ I+ KL GH Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327 Query: 302 DVVISTACHPTENIIASAA 320 + A HP E II SA+ Sbjct: 328 GSINEVAFHPDEPIIISAS 346 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 108/211 (51%), Gaps = 9/211 (4%) Query: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHF 179 + L GH V+CC F+P + + S FD + +W+V G C TL HS V +H+ Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHY 117 Query: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239 N DGS++ S+S D +WD+ +G+ +K L + S + + + D T+K Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG 299 LWD K ++T+ +N + F+ T + I+SG DN + +W+L+ ++ ++G Sbjct: 178 LWDIRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRG 233 Query: 300 HTDVVISTACHPTENIIASAALENDKTIKLW 330 H D V + + + S A++N T+++W Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDN--TVRVW 262 >6CHG-A nrPDB Length = 312 Score = 160 bits (404), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 98/275 (35%), Positives = 154/275 (56%), Gaps = 17/275 (6%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 K L K +S + SP+GE +A ++ ++ K K + HK I+ + WS Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDML-VYEISSSKMMKLTTTHKECINCLCWSP 64 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 DS + S S+D T++I + G+ ++ L GH+ V +N + N++ S S DES++ W Sbjct: 65 DSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWH 123 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLI------ 210 V +G LKT+ AHSD V ++ + D S++ S SYDGL RI+DT SG CLKTL Sbjct: 124 VLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWI 183 Query: 211 -DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE-----KYCIFA 264 +D P+S VKFS NGK++L +LDN +KLW+Y++G ++T+ E KY Sbjct: 184 AEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGL 243 Query: 265 NFSVTGGK--WIVSGSEDNLVYIWNLQTKEIVQKL 297 GK ++SG++ + +WN+ +K +VQK+ Sbjct: 244 ELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKI 278 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/110 (33%), Positives = 57/110 (51%), Gaps = 7/110 (6%) Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280 + SP+G+ I A + + +++ S K +K T HK CI K I SGSED Sbjct: 20 QISPDGELI-AICQNTDMLVYEISSSKMMKLTTTHKE---CINCLCWSPDSKCIASGSED 75 Query: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 V I ++ I ++L GHT VIS + NI+ S+++ D++IK W Sbjct: 76 FTVEITHIIYGRI-RRLMGHTAPVISICYNNKGNILCSSSM--DESIKEW 122 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 32/143 (22%), Positives = 67/143 (46%), Gaps = 8/143 (5%) Query: 165 KTLPAHSDPVSAVHFNRDGSLI-VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 + LPA ++ + DG LI + + D L +++ +S + +K L ++ + +S Sbjct: 7 QVLPASGKISTSCQISPDGELIAICQNTDML--VYEISSSKMMK-LTTTHKECINCLCWS 63 Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 P+ K I + + D T+++ G+ ++ GH I N G + S S D + Sbjct: 64 PDSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYN---NKGNILCSSSMDESI 119 Query: 284 YIWNLQTKEIVQKLQGHTDVVIS 306 W++ + ++ + H+D V+S Sbjct: 120 KEWHVLSGTALKTMSAHSDAVVS 142 >6BX3-A nrPDB Length = 314 Score = 158 bits (400), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 111/322 (34%), Positives = 164/322 (50%), Gaps = 33/322 (10%) Query: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT-ISGHK 87 TPV LK T A K SP+G++LA + ++ I+ +T ++ H Sbjct: 5 TPVGTQNGLKATCA---------KISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHA 54 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 S++ WS D + +ASDD +++I +S G L T GH+ V FN + NL+ + Sbjct: 55 RPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTS 113 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQCL 206 S DES++IWD G +KT+ AHS+ V +V D S++ S SYDGL RI+D +G CL Sbjct: 114 SMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCL 173 Query: 207 KTLIDDDN-------PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259 KTL D + P+S VKFS N +Y+L +LD +K+WD G ++T+ EK Sbjct: 174 KTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEK 233 Query: 260 YCI-------FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVISTA 308 + F N ++SG E+ +Y WN TK ++Q L G H+ V+S Sbjct: 234 GVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIH 293 Query: 309 CHPTENIIASAALENDKTIKLW 330 C NI+ S AL D + W Sbjct: 294 CF--GNIMCSLALNGDCCLWRW 313 >6Q8F-A nrPDB Length = 514 Score = 147 bits (371), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 91/317 (28%), Positives = 161/317 (50%), Gaps = 21/317 (6%) Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK-- 87 P + + +KF G V +FSP+G++L + S D I++W GK K + Sbjct: 203 PTQLSRHIKF---GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 259 Query: 88 --LGISD----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQ 140 + + D + +S D+ +L + + D +K+W + SG+CL+ + HS V C +F+ Sbjct: 260 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 319 Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 S+ I+S SFD+++RI +K+GK LK HS V+ F +DG I+S+S DG +IW+ Sbjct: 320 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 Query: 201 ASGQC------LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254 + +C L + D S + N ++ + NT+ + + +G+ +++++ Sbjct: 380 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNM-QGQIVRSFSS 438 Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314 K E G+WI ED ++Y ++ T ++ + L H VI A HP +N Sbjct: 439 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN 498 Query: 315 IIASAALENDKTIKLWK 331 +IA+ + D +KLWK Sbjct: 499 LIATYS--EDGLLKLWK 513 >6F3T-A nrPDB Length = 608 Score = 144 bits (364), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 86/294 (29%), Positives = 148/294 (50%), Gaps = 17/294 (5%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 +T + +++V + + +A AD +++W K + V +SD Sbjct: 272 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASD 320 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 +L+ SDD +I D + LK L GHS V+ +F+P N ++S S D +VR+W + Sbjct: 321 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 380 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 +T CL H+ PV F+ G VS +D + R+W T Q L+ + V+ Sbjct: 381 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVN 439 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 +F PN Y+ + D T++LWD G C++ +TGHK + + FS G+++ +G+ Sbjct: 440 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGA 496 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 D V +W++ +V +L+GHTD V S I+AS +++N T++LW + Sbjct: 497 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLWDA 548 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 66/223 (29%), Positives = 107/223 (47%), Gaps = 7/223 (3%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH+ V FSP+ +L SSS D +++W GH + D +S Sbjct: 347 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 406 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 VS D+ ++W + L+ GH V C F+P SN + +GS D +VR+WDV Sbjct: 407 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 466 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G C++ H P+ ++ F+ +G + + + DG +WD G + L + S + Sbjct: 467 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCS-L 525 Query: 221 KFSPNGKYILAATLDNTLKLWDYSKG------KCLKTYTGHKN 257 +FS +G+ + + ++DNT++LWD K T TGH N Sbjct: 526 RFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 568 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 95/192 (49%), Gaps = 3/192 (1%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH V +FSP G + S D++ ++W + + +GH ++ + +SN + Sbjct: 391 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 450 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 + S D+T+++WDV +G C++ GH + F+P + +G+ D V +WD+ G Sbjct: 451 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 510 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVSFVK 221 + L H+D V ++ F+RDG ++ S S D R+WD + L+T DD + Sbjct: 511 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 568 Query: 222 FSPNGKYILAAT 233 N + +L T Sbjct: 569 LPENSQELLLGT 580 Score = 90.9 bits (224), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 49/175 (28%), Positives = 86/175 (49%), Gaps = 24/175 (13%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 AGH V+ +F PN ++A+ SAD+ +++W +G + +GHK I + +S + Sbjct: 431 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 490 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VK 159 L + + D + +WD+ G + LKGH++ V F+ ++ SGS D +VR+WD +K Sbjct: 491 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 550 Query: 160 TGKCLKT-----------LPAHSD------------PVSAVHFNRDGSLIVSSSY 191 + L+T LP +S PV +HF R ++ + +Y Sbjct: 551 AFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 605 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 78/198 (39%), Gaps = 35/198 (17%) Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-------------------DTASG 203 C T ++AV D SLI D R+W D S Sbjct: 270 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 329 Query: 204 QCLKTLIDDDNP-----------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 L+ ++D+ PV FSP+ Y+L+++ D T++LW CL Y Sbjct: 330 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 389 Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 GH Y ++ G + VSG D + +W + ++ GH V T HP Sbjct: 390 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 446 Query: 313 ENIIASAALENDKTIKLW 330 N +A+ + D+T++LW Sbjct: 447 SNYVATGS--ADRTVRLW 462 >6ID0-T nrPDB Length = 514 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 153/309 (49%), Gaps = 16/309 (5%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 P + L ++GH V + P +W + SAD+ IKIW GK + +++GH + Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRG 251 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 V S+ S L S +DK +K WD+ K ++ GH + V+ + +P +++V+ S D + Sbjct: 252 VIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDST 311 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 RIWDV+T + TL H++ V+ V I++ S+D R+WD +G+ TL + Sbjct: 312 ARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNH 371 Query: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 V V P Y A+ + +K W + G ++ +GH I +V Sbjct: 372 KK-SVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHN----AIINTLTVNSDG 425 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VISTACHPTENIIASAALEND 324 +VSG+++ +++W+ +T Q++ G D + + A +E+ + +A E D Sbjct: 426 VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA--EAD 483 Query: 325 KTIKLWKSD 333 KTIK+++ D Sbjct: 484 KTIKVYRED 492 >5FL8-q nrPDB Length = 515 Score = 136 bits (343), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 99/340 (29%), Positives = 165/340 (48%), Gaps = 56/340 (16%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-FEKTISGHKLGISDVAWS-- 96 TL GH V V +SP+GE +A+ S D I++W G+ + GH I+ ++W Sbjct: 181 TLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPI 240 Query: 97 -----SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 L S+S D T+KIWD S C T+ GH+N V C + Q L+ SGS D Sbjct: 241 HLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQ-GLLYSGSHDR 299 Query: 152 SVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVSS--------------------S 190 +VR+WD+ + G+C+ L +H+ V+ + + D +L + + + Sbjct: 300 TVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALEN 359 Query: 191 YDGLCRIWDTASGQCLKTLIDDD-----NPP---------------VSFVKFSPNGKYIL 230 Y+ +C+ + S + + T DD NP V+ V FSP+G+YI+ Sbjct: 360 YEKICKK-NGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIV 418 Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 +A+ DN++KLWD GK + T+ GH Y + + + + +VS S+D + +W+++T Sbjct: 419 SASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWS---SDCRLLVSCSKDTTLKVWDVRT 475 Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +++ L GH D V + + S DK ++LW Sbjct: 476 RKLSVDLPGHKDEVYTVDWSVDGKRVCSGG--KDKMVRLW 513 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 88/295 (29%), Positives = 145/295 (49%), Gaps = 51/295 (17%) Query: 83 ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 I+GH I A++ S+ +V+ + D T +IWD + + TLKGH N+V C +++P Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDG 198 Query: 142 NLIVSGSFDESVRIWDVKTGKCL-KTLPAHSDPVSA-----VHFNRDGS--LIVSSSYDG 193 +I +GS D ++R+WD K+G+CL L HS +++ +H + GS + SSS DG Sbjct: 199 EVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDG 258 Query: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY-SKGKCLKTY 252 +IWDT S C T+ N VS VK+ G + + + D T+++WD S+G+C+ Sbjct: 259 TIKIWDTVSRVCQYTMSGHTN-SVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINIL 316 Query: 253 TGHKN--------EKYCI-FANFSVTGGK---------------------------WIVS 276 H + Y + F TG K +V+ Sbjct: 317 KSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVT 376 Query: 277 GSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 S+D +++WN L++ + + ++ GH +V A P I SA+ +N +IKLW Sbjct: 377 ASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDN--SIKLW 429 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 54/170 (31%), Positives = 87/170 (51%), Gaps = 3/170 (1%) Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKL 88 P P A K L + K K + E + ++S D + +W K ++GH+ Sbjct: 346 PSTPEEAQKKALENYEKICK--KNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQK 403 Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 ++ VA+S D +VSAS D ++K+WD GK + T +GH V+ ++ L+VS S Sbjct: 404 LVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCS 463 Query: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 D ++++WDV+T K LP H D V V ++ DG + S D + R+W Sbjct: 464 KDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 111/247 (44%), Gaps = 43/247 (17%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-YDGKFEKTISGHKLGISDVAWS 96 ++T++GHT +VS VK+ G L S S D+ +++W G+ + H ++ ++ S Sbjct: 271 QYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLS 329 Query: 97 SD---------------------------------------SNLLVSASDDKTLKIWD-V 116 +D ++V+ASDD T+ +W+ + Sbjct: 330 TDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPL 389 Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176 S K + + GH V F+P IVS SFD S+++WD + GK + T H V Sbjct: 390 KSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQ 449 Query: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236 V ++ D L+VS S D ++WD + + L + V V +S +GK + + D Sbjct: 450 VAWSSDCRLLVSCSKDTTLKVWDVRTRK-LSVDLPGHKDEVYTVDWSVDGKRVCSGGKDK 508 Query: 237 TLKLWDY 243 ++LW + Sbjct: 509 MVRLWTH 515 >6QX9-4B nrPDB Length = 522 Score = 134 bits (338), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 143/299 (47%), Gaps = 13/299 (4%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL- 101 G + +S FSPN + LA++ L K+W D T+ GH + + + S + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 102 -------LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 L S + D ++K+W + S + + ++GH+ V ++P + + +D S R Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348 Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 +WD++ + + HS V + F++DGSL + D R+WD +G+C+ ++ Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-MFLEGHL 407 Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274 + + FSPNG +I + DNT K+WD + +C+ T H+N F G ++ Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIHGNFL 465 Query: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 ++G+ DN IW ++ L GH V+ +IA+ + D+T KLW ++ Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLWMAE 522 Score = 124 bits (311), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 74/263 (28%), Positives = 127/263 (48%), Gaps = 13/263 (4%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEW--------LASSSADKLIKIWGAYDGKFEKTIS 84 P+ L TL GH V ++ F P LAS +AD +K+W + I Sbjct: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320 Query: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144 GH + ++ V W L + D++ ++WD+ + + + +GHS V+ F+ +L Sbjct: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380 Query: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204 +G D R+WD++TG+C+ L H + ++F+ +G I + S D C++WD + Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440 Query: 205 CLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263 C+ T+ N V+ VKF P +G ++L DNT K+W + LKT GH+ + + Sbjct: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496 Query: 264 ANFSVTGGKWIVSGSEDNLVYIW 286 + G+ I + S D +W Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 24/42 (57%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74 P ++ TLAGH V + S +G+ +A+ S D+ K+W A Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521 >5OPT-p nrPDB Length = 318 Score = 134 bits (337), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 79/257 (30%), Positives = 137/257 (53%), Gaps = 14/257 (5%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH+ VS V S NG++ S+S D +++W G + GH + V +S D+ Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNR 122 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTL--KGHSNYVFCCNFNP--QSNLIVSGSFDESVRIW 156 +VS D L++W+V G+CL TL H+++V C F+P ++ LIVSG +D V++W Sbjct: 123 QIVSGGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+ +G+ L L H++ +++V + DGSL SS DG+ R+WD G+ L + P Sbjct: 182 DIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMA--AGAP 239 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK-----YCIFANFSVTGG 271 ++ + FSPN +Y + A + ++++D + +K C+ +S G Sbjct: 240 INQICFSPN-RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGN 298 Query: 272 KWIVSGSEDNLVYIWNL 288 + SG DN++ +W++ Sbjct: 299 T-LYSGYTDNVIRVWSV 314 Score = 124 bits (311), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 83/250 (33%), Positives = 134/250 (53%), Gaps = 22/250 (8%) Query: 62 SSSADKLIKIWGA---------YDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112 S+S D + WG+ G E+ + GH +SDVA S++ + VSAS D +L+ Sbjct: 33 STSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSLR 92 Query: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL--PAH 170 +W++ +G C GH+ V F+P + IVSG D ++R+W+VK G+CL TL AH Sbjct: 93 LWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVK-GECLHTLGRGAH 151 Query: 171 SDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228 +D VS V F + + LIVS +D L ++WD ASG+ L L N ++ V SP+G Sbjct: 152 TDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTN-YITSVTVSPDGSL 210 Query: 229 ILAATLDNTLKLWDYSKGKCL-KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 ++ D +LWD +KG+ L + G + C N W+ + +E + I++ Sbjct: 211 CASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNR-----YWMCAATEKG-IRIFD 264 Query: 288 LQTKEIVQKL 297 L+ K+++ +L Sbjct: 265 LENKDVIVEL 274 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 50/113 (44%), Gaps = 10/113 (8%) Query: 230 LAATLDNTLKLW----DYSKGKCLKTYTGHKNEKYCIFANFSV--TGGKWIVSGSEDNLV 283 ++ + DNTL W D + +C + + E + F + G + VS S D+ + Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW--KSDC 334 +WNLQT K GHT V+S P I S D +++W K +C Sbjct: 92 RLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGG--RDNALRVWNVKGEC 142 Score = 34.7 bits (78), Expect = 0.061, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 43/124 (34%), Gaps = 47/124 (37%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--------------------- 79 L GHT ++SV SP+G ASS D + ++W G+ Sbjct: 192 LKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYW 251 Query: 80 -----EKTISGHKLGISDV---------------------AWSSDSNLLVSASDDKTLKI 113 EK I L DV AWS+D N L S D +++ Sbjct: 252 MCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRV 311 Query: 114 WDVS 117 W VS Sbjct: 312 WSVS 315 >3JB9-g nrPDB Length = 558 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 89/301 (29%), Positives = 144/301 (47%), Gaps = 12/301 (3%) Query: 39 FTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWS 96 FT GHTK +S ++F P +G L S S D IKIW Y D +T GH I D+++S Sbjct: 260 FTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFS 319 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN---PQSNLIVSGSFDESV 153 D +S S DKT+K+WD GKCL C F + N ++G+ D+ + Sbjct: 320 QDGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLAGTADKRI 378 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 +D+++ ++ H ++++ F +G V++S D R W+ + +K + D Sbjct: 379 LQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIA 438 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWD----YSKGKCLKTYTGHKNEKYCIFANFSVT 269 + V PNGK I +LDN + ++ Y + K K + G+ Y + FS Sbjct: 439 MHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNK-KKVFKGYSCSGYSLEVGFS-P 496 Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 G+++ SG W+ +T +++ KL H+ V S A HP E + + D +IK Sbjct: 497 DGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKY 556 Query: 330 W 330 W Sbjct: 557 W 557 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 75/171 (43%), Gaps = 4/171 (2%) Query: 162 KCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 K + T H+ +S + F G L++S S D +IW+ + L P+ + Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDL 316 Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280 FS +G+ L+ + D T+KLWD GKCL + + C+ ++G+ D Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTN-CVKFQVDPDKPNEFLAGTAD 375 Query: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + +++++ +IVQ H + S EN +D +++ W+ Sbjct: 376 KRILQFDIRSPDIVQAYDHHLGGINSITF--LENGKRFVTTSDDSSMRFWE 424 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 5/92 (5%) Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHT 301 Y K + T+ GH C+ F G ++SGS DN + IW + + +++ QGH Sbjct: 253 YIPKKHIFTWKGHTKGISCL--RFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHA 310 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWKSD 333 + + S + DKTIKLW ++ Sbjct: 311 RPIRDLSFSQDGRSFLSTSF--DKTIKLWDTE 340 >5Y88-O nrPDB Length = 451 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 148/309 (47%), Gaps = 18/309 (5%) Query: 35 YALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 + L + GH V V P + EW + S D +K+W GK + T++GH + + DV Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDV 188 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 A S L S S+DKT+K WD+ + ++ GH + V + +P +LI + D + Sbjct: 189 AVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVI 248 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 ++WD++T + TL H P++ V +VSSS D R+WD +G+ +K L Sbjct: 249 KLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHK 308 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273 V P ++ +A+ + ++ W ++G L T ++EK I S+ Sbjct: 309 R-SVRATALHPK-EFSVASACTDDIRSWGLAEGSLL---TNFESEKTGIINTLSINQDDV 363 Query: 274 IVSGSEDNLVYIWN---------LQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324 + +G ++ ++ ++ L T+E+V L+G V+ ST +I A D Sbjct: 364 LFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEA---D 420 Query: 325 KTIKLWKSD 333 K+IK+WK D Sbjct: 421 KSIKIWKQD 429 >5YZG-W nrPDB Length = 579 Score = 128 bits (322), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 146/299 (48%), Gaps = 15/299 (5%) Query: 42 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDS 99 +GHTK VS+V+ P +G L S S D IK+W Y + + +T GH + D+ +++ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIW 156 +SA+ D+ LK+WD +G+C+ + +C FNP + NL V+G D+ + W Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFT-NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQW 403 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+++G+ ++ H V+ + F + VS+S D R+W+ K + + Sbjct: 404 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKW 273 + V SPNGK++ ++DN + ++ L K + GH Y +FS + Sbjct: 464 MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSY 522 Query: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE--NIIASAALENDKTIKLW 330 ++SG + + IW+ +T ++ + + H V I HP E +I D IKLW Sbjct: 523 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578 >6QDV-o nrPDB Length = 513 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 146/299 (48%), Gaps = 15/299 (5%) Query: 42 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDS 99 +GHTK VS+V+ P +G L S S D IK+W Y + + +T GH + D+ +++ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 278 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIW 156 +SA+ D+ LK+WD +G+C+ + +C FNP + NL V+G D+ + W Sbjct: 279 TQFLSAAYDRYLKLWDTETGQCISRFT-NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQW 337 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+++G+ ++ H V+ + F + VS+S D R+W+ K + + Sbjct: 338 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 397 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKW 273 + V SPNGK++ ++DN + ++ L K + GH Y +FS + Sbjct: 398 MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSY 456 Query: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE--NIIASAALENDKTIKLW 330 ++SG + + IW+ +T ++ + + H V I HP E +I D IKLW Sbjct: 457 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 512 >4V8M-A7 nrPDB Length = 318 Score = 127 bits (320), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 98/319 (30%), Positives = 162/319 (50%), Gaps = 34/319 (10%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEW---LASSSADKLIKIWGAYDGKF---------EKTI 83 A + L GH V+S+ E + S+S DK + WG + ++ + Sbjct: 4 AYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRL 63 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 GH +SDVA S++ N VSAS D +L++W++ +G+C GH+ V F+P + Sbjct: 64 EGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQ 123 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWD 199 IVSG D ++R+W+VK G+C+ TL AH+D VS V F + D +IVS +D L ++WD Sbjct: 124 IVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL-KTYTGHKNE 258 A+G+ + L N V+ V SP+G ++ D +LWD +KG+ L + G Sbjct: 183 LATGRLVTDLKGHTN-YVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL----QGHTDVV---ISTACHP 311 + C N W+ + +E + I++L+ K+I+ +L QG +V +S A Sbjct: 242 QICFSPNR-----YWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSA 295 Query: 312 TENIIASAALENDKTIKLW 330 + + S +N I++W Sbjct: 296 DGSTLYSGYTDN--VIRVW 312 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 112/222 (50%), Gaps = 13/222 (5%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGIS 91 N ++ GHTK V SV FSP+ + S D +++W G+ T+S H +S Sbjct: 98 NGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV-KGECMHTLSRGAHTDWVS 156 Query: 92 DVAWSS--DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 V +S D+ ++VS D +K+WD+++G+ + LKGH+NYV +P +L S Sbjct: 157 CVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDK 216 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 D R+WD+ G+ L + A + P++ + F+ + + +++ G+ RI+D + + L Sbjct: 217 DGVARLWDLTKGEALSEMAAGA-PINQICFSPNRYWMCAATEKGI-RIFDLENKDIIVEL 274 Query: 210 IDDDN------PPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 + P + +S +G + + DN +++W S+ Sbjct: 275 APEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSE 316 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 10/114 (8%) Query: 229 ILAATLDNTLKLW----DYSKGKCLKTYTGHKNEKYCIFANFSV--TGGKWIVSGSEDNL 282 +++ + D TL W D +C + E + F + G + VS S D+ Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW--KSDC 334 + +WNLQ + K GHT V+S A P I S +N +++W K +C Sbjct: 91 LRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDN--ALRVWNVKGEC 142 >6MZM-G nrPDB Length = 800 Score = 127 bits (318), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 114/210 (54%), Gaps = 6/210 (2%) Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182 K L GHS V+ +F+P N ++S S D +VR+W ++T CL H+ PV F+ Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 G VS +D + R+W T Q L+ + V+ +F PN Y+ + D T++LWD Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 G C++ +TGHK + + FS G+++ +G+ D V +W++ +V +L+GHTD Sbjct: 656 VLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD 712 Query: 303 VVISTACHPTENIIASAALENDKTIKLWKS 332 V S I+AS +++N T++LW + Sbjct: 713 TVCSLRFSRDGEILASGSMDN--TVRLWDA 740 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 66/223 (29%), Positives = 107/223 (47%), Gaps = 7/223 (3%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH+ V FSP+ +L SSS D +++W GH + D +S Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 VS D+ ++W + L+ GH V C F+P SN + +GS D +VR+WDV Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G C++ H P+ ++ F+ +G + + + DG +WD G + L + V + Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTD-TVCSL 717 Query: 221 KFSPNGKYILAATLDNTLKLWDYSKG------KCLKTYTGHKN 257 +FS +G+ + + ++DNT++LWD K T TGH N Sbjct: 718 RFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 101/207 (48%), Gaps = 4/207 (1%) Query: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140 K + GH + ++S D N L+S+S+D T+++W + + CL KGH+ V+ F+P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 VSG D R+W + L+ H V+ F+ + + + + S D R+WD Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV 656 Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260 +G C++ P+ + FSPNG+++ D + LWD G + GH + Sbjct: 657 LNGNCVRIFTGHKG-PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH-TDTV 714 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWN 287 C FS G+ + SGS DN V +W+ Sbjct: 715 CSL-RFS-RDGEILASGSMDNTVRLWD 739 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 95/192 (49%), Gaps = 3/192 (1%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH V +FSP G + S D++ ++W + + +GH ++ + +SN + Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 + S D+T+++WDV +G C++ GH + F+P + +G+ D V +WD+ G Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVSFVK 221 + L H+D V ++ F+RDG ++ S S D R+WD + L+T DD + Sbjct: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760 Query: 222 FSPNGKYILAAT 233 N + +L T Sbjct: 761 LPENSQELLLGT 772 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 49/175 (28%), Positives = 86/175 (49%), Gaps = 24/175 (13%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 AGH V+ +F PN ++A+ SAD+ +++W +G + +GHK I + +S + Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 682 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VK 159 L + + D + +WD+ G + LKGH++ V F+ ++ SGS D +VR+WD +K Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742 Query: 160 TGKCLKT-----------LPAHSD------------PVSAVHFNRDGSLIVSSSY 191 + L+T LP +S PV +HF R ++ + +Y Sbjct: 743 AFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797 >3JB9-L nrPDB Length = 340 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 95/341 (27%), Positives = 168/341 (49%), Gaps = 22/341 (6%) Query: 5 EKKPETEAA-------RAQPTPSSSATQSKPTPVKPNYAL-KFTLAGHTKAVSSVKFSPN 56 +K+ E+E+A R + SS T+ + + + GHT V +F P+ Sbjct: 2 DKRKESESATNGHLVKRIRIQDSSLITEGSVLQRTSDLNVPNLQMFGHTAEVLVARFDPS 61 Query: 57 GEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115 G + AS D+ I +W + D K ++G K I+D+ WS DS ++ +S D L WD Sbjct: 62 GSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWD 121 Query: 116 VSSGKCLKTLKGHSNYVFCCN-FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 SG+ ++ KGH+ V + S L+ S S D ++++WD ++ C+KT+ P+ Sbjct: 122 AVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKY-PL 180 Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 +AV + G+ + DG +IWD + C L ++ + S +G +L+ ++ Sbjct: 181 TAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVL-KGHKDIITSLAISKDGSSLLSNSM 239 Query: 235 DNTLKLWDY----SKGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 DNT++++D S + L+ + G H E + +S +++ +GS D VY+W+ Sbjct: 240 DNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-RNSRFVGAGSSDKNVYVWS- 297 Query: 289 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 T ++ L GH V HP ++II S + +D+TI L Sbjct: 298 ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCS--SDRTIFL 336 >5WYJ-BC nrPDB Length = 817 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 82/269 (30%), Positives = 145/269 (53%), Gaps = 16/269 (5%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 ++T H K ++++ SPN A++S DK KIW +G+ E T++ HK G+ DV++ Sbjct: 484 EYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQ 543 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF-NPQSNLIVSGSFDESVRIW 156 LL ++S DKT+KIW + + +KTL+GH+N V C+F N Q LI G+ D ++IW Sbjct: 544 YDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGA-DGLIKIW 602 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-------KTL 209 D +G+CLKTL H++ + A+ DG +IVS+ DG+ + W + Q + K Sbjct: 603 DCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQ 662 Query: 210 IDDDNPPVSFV-KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 ++ + +++ K ++LA TLD+ ++L++ K ++ + E+ I F+ Sbjct: 663 VEQEQSLQNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIFNE 722 Query: 269 TGGKWIVSGSEDNLVYI------WNLQTK 291 + I +++ L+ + WN K Sbjct: 723 ELDQAISILNDEQLILLMKRCRDWNTNAK 751 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/294 (26%), Positives = 133/294 (45%), Gaps = 33/294 (11%) Query: 14 RAQPTPSSSATQ-SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72 R P P S + S P V+ GH ++S+ + +G W+A++S D +W Sbjct: 363 RIIPVPDLSGPEASLPLDVE-------IYEGHEDLLNSLDATEDGLWIATASKDNTAIVW 415 Query: 73 GAYDG--KFE---KTISGHK-----LGISDVAWSSDSNLLVSASDDKTLKIW-------- 114 + KF+ K I GH +G+ ++ L++AS+D T+K W Sbjct: 416 RYNENSCKFDIYAKYI-GHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTAS 474 Query: 115 -DVSSGKCLK-TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 DV K + T H + + +P ++ + S+D++ +IW+++ G+ TL H Sbjct: 475 MDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKR 534 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 + V F + L+ +SS D +IW + +KTL N V F K +++ Sbjct: 535 GLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNA-VQRCSFINKQKQLISC 593 Query: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 D +K+WD S G+CLKT GH N ++A ++ G IVS D + W Sbjct: 594 GADGLIKIWDCSSGECLKTLDGHNNR---LWALSTMNDGDMIVSADADGVFQFW 644 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 51/154 (33%), Positives = 74/154 (48%), Gaps = 4/154 (2%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLAS 62 + + A P S AT S K N L+ TLA H + + V F + LA+ Sbjct: 491 EKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLAT 550 Query: 63 SSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCL 122 SS DK +KIW KT+ GH + ++ + L+S D +KIWD SSG+CL Sbjct: 551 SSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECL 610 Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 KTL GH+N ++ + ++IVS D + W Sbjct: 611 KTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/235 (24%), Positives = 99/235 (42%), Gaps = 23/235 (9%) Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD----SNL 101 + ++++K +P+G++L S +L+KI+ GK +++ IS ++ D S L Sbjct: 62 QEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMK-----ISSPSYILDADSTSTL 116 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN----LIVSGSFDESVRIWD 157 L D ++ + D+ +G + KGH + F Q N L+ SG + V++WD Sbjct: 117 LAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWD 176 Query: 158 VKTGKCLKTLPAHSDPVSAVHF-----NRDGSL-IVSSSYDGLCRIWD----TASGQCLK 207 + KCL TL H+ V + N + SL ++S D + +WD Sbjct: 177 LVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKT 236 Query: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 ++ F+K + I A D +L D G LK E + I Sbjct: 237 LPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFII 291 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 58/120 (48%), Gaps = 11/120 (9%) Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIV 275 ++ + SPN A+ D T K+W+ G+ T HK + + F + K + Sbjct: 494 INALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD----KLLA 549 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA-CHPTENIIASAALENDKTIKLWKSDC 334 + S D V IW+L T +++ L+GHT+ V + + + +I+ A D IK+W DC Sbjct: 550 TSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGA---DGLIKIW--DC 604 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 62/280 (22%), Positives = 108/280 (38%), Gaps = 74/280 (26%) Query: 24 TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKL--IKIWGAYDGKFEK 81 T K + P YA + AV++V S NG+ LA+ D++ I + K Sbjct: 5 TSYKGISLNPIYA-------GSSAVATV--SENGKILATPVLDEINIIDLTPGSRKILHK 55 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 + + I+ + + D L S + LKI+ + +GK ++++K S+ + + + S Sbjct: 56 ISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMK-ISSPSYILDADSTS 114 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL-CRIWDT 200 L+ G D S+ + D++ G + H +S++ F Y L +IW Sbjct: 115 TLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKF-----------YGQLNSKIWLL 163 Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260 ASG NG +K+WD K KCL T H + Sbjct: 164 ASGDT-------------------NG----------MVKVWDLVKRKCLHTLQEHTS--- 191 Query: 261 CIFANFSVTGGKWI------------VSGSEDNLVYIWNL 288 +V G I +SG D+++ +W+ Sbjct: 192 ------AVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDF 225 Score = 34.7 bits (78), Expect = 0.054, Method: Compositional matrix adjust. Identities = 30/165 (18%), Positives = 66/165 (40%), Gaps = 13/165 (7%) Query: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT 233 ++A+ DG + S L +I+ +G+ ++++ + P + + Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSM--KISSPSYILDADSTSTLLAVGG 121 Query: 234 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV-SGSEDNLVYIWNLQTKE 292 D ++ + D G ++ GH + + W++ SG + +V +W+L ++ Sbjct: 122 TDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRK 181 Query: 293 IVQKLQGHTDVV-------ISTACHPTENIIASAALENDKTIKLW 330 + LQ HT V + P+ N+++ D I LW Sbjct: 182 CLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGG---RDDIINLW 223 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 39/181 (21%), Positives = 81/181 (44%), Gaps = 14/181 (7%) Query: 157 DVKT---GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG--QCLKTLID 211 D+KT G L + A S V+ V N G ++ + D + I D G + L + + Sbjct: 2 DLKTSYKGISLNPIYAGSSAVATVSEN--GKILATPVLDEI-NIIDLTPGSRKILHKISN 58 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 +D ++ +K +P+G+Y+ + LK++ GK +++ + Y + A+ + T Sbjct: 59 EDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMK-ISSPSYILDADSTST-- 115 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKL 329 + G D + + +++ I +GH + S + N I A+ + + +K+ Sbjct: 116 -LLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKV 174 Query: 330 W 330 W Sbjct: 175 W 175 >6HQA-B nrPDB Length = 722 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 107/205 (52%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH+ AV V FSP+ +L S S DK +++W + GH + DV +S + Sbjct: 449 LVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGH 508 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 +AS D+T ++W L+ GH N V C F+P S + +GS D++ R+WD+ Sbjct: 509 YFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIAR 568 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G+C++ HS ++ + + DG + S+ D + +WD ++G+ +K + + + Sbjct: 569 GECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSL 628 Query: 221 KFSPNGKYILAATLDNTLKLWDYSK 245 FS G +++ DN++++WD K Sbjct: 629 AFSREGTVLVSTGADNSVRVWDVKK 653 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 71/273 (26%), Positives = 133/273 (48%), Gaps = 26/273 (9%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--------------------- 77 +T ++ +KF+ + +AS D IK+W + DG Sbjct: 384 YTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLW-SIDGSPLRSLLKNDPYNQQNNDGVA 442 Query: 78 -KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136 K + + GH + V +S D+ L+S S+DKT+++W + + CL + KGHS+ V+ Sbjct: 443 VKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVK 502 Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196 F+P + + S D++ R+W L+ H + V V F+ + + + + S D R Sbjct: 503 FSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTAR 562 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 +WD A G+C++ + ++ + SP+G+++ +A D+ + LWD S G+ +K GH Sbjct: 563 MWDIARGECVRVFMGHSG-AINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHG 621 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 + I++ G +VS DN V +W+++ Sbjct: 622 --RSSIYSLAFSREGTVLVSTGADNSVRVWDVK 652 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 50/166 (30%), Positives = 90/166 (54%), Gaps = 1/166 (0%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 Y + GH+ +V VKFSP G + A++S D+ ++W + +GH + V Sbjct: 485 YTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVE 544 Query: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 + +S L + S DKT ++WD++ G+C++ GHS + C +P + S D V Sbjct: 545 FHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVC 604 Query: 155 IWDVKTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 +WD+ TG+ +K + H + ++ F+R+G+++VS+ D R+WD Sbjct: 605 LWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWD 650 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 97/231 (41%), Gaps = 27/231 (11%) Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG------------------- 161 C+ T +N + C FN S ++ SG D +++W + Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 162 --KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 K + L HS V V F+ D ++S S D R+W + CL + + V Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSY-KGHSSSVWD 500 Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279 VKFSP G Y A+ D T +LW L+ + GH N+ C+ + + T ++ +GS Sbjct: 501 VKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNST---YLFTGSS 557 Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 D +W++ E V+ GH+ + A P +ASA D + LW Sbjct: 558 DKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAG--EDSVVCLW 606 >4V6W-Ag nrPDB Length = 318 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 87/302 (28%), Positives = 154/302 (50%), Gaps = 23/302 (7%) Query: 1 MATEEKKPET--EAARAQPTPSSSATQSKPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNG 57 +AT K P+T A+R + T+ + T NY + L GH+ +S V S +G Sbjct: 21 IATNPKDPDTIISASRDKTLIVWKLTRDEDT----NYGYPQKRLYGHSHFISDVVLSSDG 76 Query: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117 + S S D+ +++W GK + GH + VA+S+D+ +VS S DKT+K+W+ + Sbjct: 77 NYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN-T 135 Query: 118 SGKCLKTLK--GHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 173 +C T++ GH+++V C F+P + +IVS +D +V++W++ K H+ Sbjct: 136 LAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGY 195 Query: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT 233 ++ V + DGSL S D +WD G+ L TL + N ++ + FSPN +Y L Sbjct: 196 LNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL--EHNDIINALCFSPN-RYWLCVA 252 Query: 234 LDNTLKLWDYSKGKCLKTY-------TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 ++K+WD + K ++ T ++ C+ +S T G+ + +G DN + +W Sbjct: 253 YGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWS-TDGQTLFAGYSDNTIRVW 311 Query: 287 NL 288 + Sbjct: 312 QV 313 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/313 (29%), Positives = 156/313 (49%), Gaps = 25/313 (7%) Query: 37 LKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD------GKFEKTISGHKLG 89 L+ TL GH V+ + +P + + + S+S DK + +W G +K + GH Sbjct: 7 LRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHF 66 Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 ISDV SSD N +S S D+TL++WD+++GK + +GH+ V F+ + IVSGS Sbjct: 67 ISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSR 126 Query: 150 DESVRIWDVKTGKCLKTLP--AHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQC 205 D+++++W+ +C T+ H+D VS V F N +IVS +D ++W+ A+ + Sbjct: 127 DKTIKLWNT-LAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK- 184 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 LK N ++ V SP+G + D+ LWD + GK L YT N+ I Sbjct: 185 LKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNL--YTLEHND---IINA 239 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA------ 319 + ++ + + + IW+L K+ V++L+ S A P +A + Sbjct: 240 LCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTL 299 Query: 320 -ALENDKTIKLWK 331 A +D TI++W+ Sbjct: 300 FAGYSDNTIRVWQ 312 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 16/86 (18%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD----------- 92 H ++++ FSPN WL + IKIW D +KT+ + + Sbjct: 233 HNDIINALCFSPNRYWLCVAYGPS-IKIW---DLACKKTVEELRPEVVSPTSKADQPQCL 288 Query: 93 -VAWSSDSNLLVSASDDKTLKIWDVS 117 +AWS+D L + D T+++W VS Sbjct: 289 SLAWSTDGQTLFAGYSDNTIRVWQVS 314 >6G51-g nrPDB Length = 317 Score = 113 bits (283), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 89/275 (32%), Positives = 140/275 (50%), Gaps = 19/275 (6%) Query: 27 KPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 K T + NY + + L GH+ VS V S +G++ S S D +++W G + G Sbjct: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103 Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN- 142 H + VA+SSD+ +VS S DKT+K+W+ + G C T++ HS +V C F+P S+ Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSN 162 Query: 143 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 +IVS +D+ V++W++ K H+ ++ V + DGSL S DG +WD Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222 Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK-------TYTG 254 G+ L TL D ++ + FSPN +Y L A ++K+WD +GK + T Sbjct: 223 EGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTS 278 Query: 255 HKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 K E C +S G + +G DNLV +W + Sbjct: 279 SKAEPPQCTSLAWSADGQT-LFAGYTDNLVRVWQV 312 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 86/282 (30%), Positives = 141/282 (50%), Gaps = 20/282 (7%) Query: 37 LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90 L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH + Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSGS D Sbjct: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 Query: 151 ESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCL 206 +++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ + L Sbjct: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 KT ++ V SP+G + D LWD ++GK L T G I Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 + ++ + + + IW+L+ K IV +L+ VIST+ Sbjct: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQE---VISTS 278 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 101/214 (47%), Gaps = 11/214 (5%) Query: 124 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 177 TLKGH+ +V PQ ++I+S S D+++ +W + G + L HS VS V Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237 + DG +S S+DG R+WD +G + + +S V FS + + I++ + D T Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128 Query: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 +KLW+ + G C T + ++ FS + IVS D LV +WNL ++ Sbjct: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187 Query: 297 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 GHT + + P ++ AS D LW Sbjct: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 10/109 (9%) Query: 229 ILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 IL+A+ D T+ +W ++ G + GH + + + + G++ +SGS D + Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS---SDGQFALSGSWDGTL 87 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 +W+L T ++ GHT V+S A I S + DKTIKLW + Sbjct: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS--RDKTIKLWNT 134 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 11/137 (8%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 N LK GHT +++V SP+G AS D +W +GK T+ G + I+ + Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ---------SNLI 144 +S + L +A+ ++KIWD+ + LK PQ + Sbjct: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298 Query: 145 VSGSFDESVRIWDVKTG 161 +G D VR+W V G Sbjct: 299 FAGYTDNLVRVWQVTIG 315 >5K1B-B nrPDB Length = 677 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 133/277 (48%), Gaps = 19/277 (6%) Query: 31 VKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG---H 86 V+ +Y ++ + + + V++++ P L ++ D +I+IW K + I+ H Sbjct: 15 VQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHH 74 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 ++D+ + L+SAS D T+K+W+ G C+ TL+ H +YV + L+ S Sbjct: 75 TDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVAS 134 Query: 147 GSFDESVRIWDVKTGKCL---------KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 D + +WDV T L +L + D + ++ N+ G++IVS S + + R+ Sbjct: 135 AGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRV 194 Query: 198 WDTAS-GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 WD + + +K DN V + + +G L+ + D T++LW + +C+ TY H Sbjct: 195 WDPRTCAKLMKLKGHTDN--VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHD 252 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293 + + N + T + SG D +Y +L+ +I Sbjct: 253 EGVWALQVNDAFTH---VYSGGRDRKIYCTDLRNPDI 286 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 22/231 (9%) Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYV----FCCNFNPQS 141 G++ + N L +A D ++IW V+ K + +++ H+++V CCN Sbjct: 32 GVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN----G 87 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD-- 199 ++S S D +V++W+ G C+ TL H D V A+ + +D L+ S+ D +WD Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 147 Query: 200 -----TASGQCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253 TAS + T + + + + + G I++ + + L++WD L Sbjct: 148 TLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLK 207 Query: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304 GH + + N G +SGS D + +W+L + + + H + V Sbjct: 208 GHTDNVKALLLN---RDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGV 255 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 103/217 (47%), Gaps = 18/217 (8%) Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK---CLKTLPAHSDPVSAVHFNRD 182 K + N V +P N + + D +RIW V K + ++ H+D V+ + + Sbjct: 27 KYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCN 86 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 G ++S+S D ++W+ G C+ TL + V + ++ + + + +A LD + LWD Sbjct: 87 GKTLISASSDTTVKVWNAHKGFCMSTLRTHKDY-VKALAYAKDKELVASAGLDRQIFLWD 145 Query: 243 YSKGKCL---------KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293 + L + +G+K+ Y + N G IVSGS + ++ +W+ +T Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMN---QLGTIIVSGSTEKVLRVWDPRTCAK 202 Query: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 + KL+GHTD V + + S + +D TI+LW Sbjct: 203 LMKLKGHTDNVKALLLNRDGTQCLSGS--SDGTIRLW 237 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 88/187 (47%), Gaps = 10/187 (5%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW---------GAYDGKFEKTISGHKLGI 90 TL H V ++ ++ + E +AS+ D+ I +W + + ++SG+K I Sbjct: 112 TLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSI 171 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 +A + ++VS S +K L++WD + L LKGH++ V N +SGS D Sbjct: 172 YSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 231 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 ++R+W + +C+ T H + V A+ N + + S D D + ++ LI Sbjct: 232 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLI 290 Query: 211 DDDNPPV 217 ++ PV Sbjct: 291 CEEKAPV 297 >6EOJ-D nrPDB Length = 470 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 119/253 (47%), Gaps = 1/253 (0%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 + + + H AV+++K+S + +W+ S AD +IKIW ++ + H I D+A Sbjct: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 Query: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 +SS+ + V+ SDD LKIW+ S+GK + L GH V C+++P+ LI S S D V+ Sbjct: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 +WD ++G C+ ++ V F G+L+++ S D CR++D + D+ Sbjct: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273 ++ N A D +LK +D + T CI + G Sbjct: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 Query: 274 IVSGSEDNLVYIW 286 + ++D + W Sbjct: 365 FATAAKDRTIRFW 377 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 72/305 (23%), Positives = 139/305 (45%), Gaps = 14/305 (4%) Query: 34 NYALKFTLAGHTKA---VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90 N KFT K + +++++P G L ++ +W A FE + H + Sbjct: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAV 138 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 + + +S DS+ ++S D +KIW + + H+ + F+ + V+ S D Sbjct: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDD 198 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 ++IW+ GK + L H V + ++ + LI S+S D L ++WD SG C+ +++ Sbjct: 199 NILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSIL 258 Query: 211 DDDNPPVSFVKFSPN-GKYILAATLDNTLKLWD--YSKGK--CLKTYTGHKNEKYCIFAN 265 + V +F P G ++A + D + +++D YS + C++ T + ++ Sbjct: 259 KFKH-TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINE 317 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325 T + GS + + NL + I+ H + S + +P +I A+AA D+ Sbjct: 318 SMFTLACY--DGSLKHFDLLQNLN-EPILTIPYAHDKCITSLSYNPVGHIFATAA--KDR 372 Query: 326 TIKLW 330 TI+ W Sbjct: 373 TIRFW 377 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 48/218 (22%) Query: 32 KPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90 +PN+++ K A HT+++ + FS N + S D ++KIW +GK E+ +SGH + Sbjct: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDV 222 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSF 149 W + L+ SAS D +K+WD SG C+ ++ + V F P + NL+++ S Sbjct: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 Query: 150 DESVRIWDVKTGK----CLK---------------------------------------- 165 D+S R++D++ C++ Sbjct: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 Query: 166 -TLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 T+P AH ++++ +N G + +++ D R W A Sbjct: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 >5Z56-q nrPDB Length = 504 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 104/192 (54%), Gaps = 2/192 (1%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 TL GHTK V+SV F P+ + + S+S D I+IW + + + H+ ++ ++ + Sbjct: 259 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCNFNPQSNLIVSGSFDESVRIWD 157 + L+S+SDD+ D+ +G+ L + ++ + C F+P + +G+ D ++IWD Sbjct: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 378 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 +K + P HS P++++ F+ +G + +++ D ++WD + KTL D+N V Sbjct: 379 LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEV 438 Query: 218 SFVKFSPNGKYI 229 + F +G Y+ Sbjct: 439 KSLIFDQSGTYL 450 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 58/203 (28%), Positives = 107/203 (52%), Gaps = 4/203 (1%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 SD+N +++ DK + ++D SS + L TLKGH+ V F+P +L+ S S D ++RIW Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP- 215 V C++ + AH V+ + + G ++SSS D D +G+ L + D+ + Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 ++ +F P+G T+D+ +K+WD + + + GH I FS G ++ Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSI--AFS-ENGYYLA 408 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQ 298 + ++D+ V +W+L+ + + LQ Sbjct: 409 TAADDSSVKLWDLRKLKNFKTLQ 431 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 13/275 (4%) Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119 + + ADK + ++ + T+ GH ++ V + +L+ SAS D T++IW V + Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296 Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD--PVSAV 177 C++ ++ H + V + + + ++S S D+ D++TG+ L + + ++ Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356 Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237 F+ DG + + + D +IWD + + P++ + FS NG Y+ A D++ Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITSIAFSENGYYLATAADDSS 415 Query: 238 LKLWDYSKGKCLKTYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 +KLWD K K KT N K IF G ++ G D +YI Q EI+ Sbjct: 416 VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ----SGTYLALGGTDVQIYICK-QWTEILH 470 Query: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 H+ + A IAS + D+++K + Sbjct: 471 -FTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 502 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/215 (21%), Positives = 94/215 (43%), Gaps = 12/215 (5%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG--I 90 PN + + H AV+ + G++L SSS D+ G+ ++ G + Sbjct: 294 PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSL 353 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 + + D + + + D +KIWD+ + GHS + F+ + + + D Sbjct: 354 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADD 413 Query: 151 ESVRIWDVKTGKCLKTLPAHSD-PVSAVHFNRDGSLIVSSSYDG---LCRIWDTASGQCL 206 SV++WD++ K KTL ++ V ++ F++ G+ + D +C+ W + L Sbjct: 414 SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWT----EIL 469 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 + + + V F + K+I + +D +LK + Sbjct: 470 H--FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502 >4LG8-A nrPDB Length = 354 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 104/192 (54%), Gaps = 2/192 (1%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 TL GHTK V+SV F P+ + + S+S D I+IW + + + H+ ++ ++ + Sbjct: 109 TLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 168 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCNFNPQSNLIVSGSFDESVRIWD 157 + L+S+SDD+ D+ +G+ L + ++ + C F+P + +G+ D ++IWD Sbjct: 169 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 228 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 +K + P HS P++++ F+ +G + +++ D ++WD + KTL D+N V Sbjct: 229 LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEV 288 Query: 218 SFVKFSPNGKYI 229 + F +G Y+ Sbjct: 289 KSLIFDQSGTYL 300 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 58/203 (28%), Positives = 107/203 (52%), Gaps = 4/203 (1%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 SD+N +++ DK + ++D SS + L TLKGH+ V F+P +L+ S S D ++RIW Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 141 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP- 215 V C++ + AH V+ + + G ++SSS D D +G+ L + D+ + Sbjct: 142 SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 201 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 ++ +F P+G T+D+ +K+WD + + + GH I FS G ++ Sbjct: 202 SLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSI--AFS-ENGYYLA 258 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQ 298 + ++D+ V +W+L+ + + LQ Sbjct: 259 TAADDSSVKLWDLRKLKNFKTLQ 281 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 13/275 (4%) Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119 + + ADK + ++ + T+ GH ++ V + +L+ SAS D T++IW V + Sbjct: 87 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 146 Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD--PVSAV 177 C++ ++ H + V + + + ++S S D+ D++TG+ L + + ++ Sbjct: 147 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 206 Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237 F+ DG + + + D +IWD + + P++ + FS NG Y+ A D++ Sbjct: 207 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANF-PGHSGPITSIAFSENGYYLATAADDSS 265 Query: 238 LKLWDYSKGKCLKTYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 +KLWD K K KT N K IF G ++ G D +YI Q EI+ Sbjct: 266 VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQ----SGTYLALGGTDVQIYICK-QWTEILH 320 Query: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 H+ + A IAS + D+++K + Sbjct: 321 -FTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 352 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/215 (21%), Positives = 94/215 (43%), Gaps = 12/215 (5%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG--I 90 PN + + H AV+ + G++L SSS D+ G+ ++ G + Sbjct: 144 PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSL 203 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 + + D + + + D +KIWD+ + GHS + F+ + + + D Sbjct: 204 TCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADD 263 Query: 151 ESVRIWDVKTGKCLKTLPAHSD-PVSAVHFNRDGSLIVSSSYD---GLCRIWDTASGQCL 206 SV++WD++ K KTL ++ V ++ F++ G+ + D +C+ W + L Sbjct: 264 SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWT----EIL 319 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 + + + V F + K+I + +D +LK + Sbjct: 320 H--FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 352 >3DM0-A nrPDB Length = 694 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 84/276 (30%), Positives = 141/276 (51%), Gaps = 23/276 (8%) Query: 37 LKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWG------AYDGKFEKTISGHKL 88 LK T+ HT V+++ +P N + + S+S DK I +W AY G ++ ++GH Sbjct: 374 LKGTMRAHTDMVTAIA-TPIDNADIIVSASRDKSIILWKLTKDDKAY-GVAQRRLTGHSH 431 Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 + DV SSD +S S D L++WD+++G + GH+ V F+ + IVS S Sbjct: 432 FVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSAS 491 Query: 149 FDESVRIWDVKTGKCLKTL----PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTAS 202 D ++++W+ G+C T+ H D VS V F N IVS+S+D ++W+ ++ Sbjct: 492 RDRTIKLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN 550 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 + L++ + VS V SP+G + D + LWD ++GK K Y+ N I Sbjct: 551 CK-LRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGK--KLYSLEANS--VI 605 Query: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 A W+ + +E + IW+L++K IV+ L+ Sbjct: 606 HALCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLK 640 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 20/225 (8%) Query: 119 GKCLK-TLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIW-----DVKTGKCLKTLPAH 170 G LK T++ H++ V P N +IVS S D+S+ +W D G + L H Sbjct: 371 GLVLKGTMRAHTDMVTAIA-TPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGH 429 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 S V V + DG +S S+DG R+WD A+G + + +S V FS + + I+ Sbjct: 430 SHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLS-VAFSLDNRQIV 488 Query: 231 AATLDNTLKLWDYSKGKCLKTYT----GHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYI 285 +A+ D T+KLW+ + G+C T + GH++ C+ FS T IVS S D V + Sbjct: 489 SASRDRTIKLWN-TLGECKYTISEGGEGHRDWVSCV--RFSPNTLQPTIVSASWDKTVKV 545 Query: 286 WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 WNL ++ L GHT V + A P ++ AS D + LW Sbjct: 546 WNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGG--KDGVVLLW 588 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/229 (30%), Positives = 117/229 (51%), Gaps = 27/229 (11%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS----GHKLGISDVAWS 96 GHTK V SV FS + + S+S D+ IK+W G+ + TIS GH+ +S V +S Sbjct: 468 FVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFS 526 Query: 97 SDS--NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 ++ +VSAS DKT+K+W++S+ K TL GH+ YV +P +L SG D V Sbjct: 527 PNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVL 586 Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL----- 209 +WD+ GK L +L A+S + A+ F+ + + +++ G+ +IWD S ++ L Sbjct: 587 LWDLAEGKKLYSLEANS-VIHALCFSPNRYWLCAATEHGI-KIWDLESKSIVEDLKVDLK 644 Query: 210 -----IDDDNPPVSFVK--------FSPNGKYILAATLDNTLKLWDYSK 245 D+ P + K +S +G + + D +++W + Sbjct: 645 AEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGR 693 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 67/144 (46%), Gaps = 21/144 (14%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 N L+ TLAGHT VS+V SP+G AS D ++ +W +GK ++ + + I + Sbjct: 550 NCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSV-IHAL 608 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----------------GHSNYVFCCN 136 +S + L +A++ +KIWD+ S ++ LK ++C + Sbjct: 609 CFSPNRYWLCAATE-HGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTS 667 Query: 137 FN--PQSNLIVSGSFDESVRIWDV 158 N + + SG D +R+W + Sbjct: 668 LNWSADGSTLFSGYTDGVIRVWGI 691 >6GMH-W nrPDB Length = 305 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 73/251 (29%), Positives = 128/251 (50%), Gaps = 4/251 (1%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 L+++L GH V SV S ASSS D I++W +GK K+I + +A+S Sbjct: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 DS L + + + I+ V SGK +L ++ ++P + SG+ D + I+ Sbjct: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+ TGK L TL H+ P+ ++ F+ D L+V++S DG +I+D TL Sbjct: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-SGHASW 234 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V V F P+ + ++++ D ++K+WD C+ T+ H+++ + + N G IVS Sbjct: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN---GNGSKIVS 291 Query: 277 GSEDNLVYIWN 287 +D ++I++ Sbjct: 292 VGDDQEIHIYD 302 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 116/228 (50%), Gaps = 11/228 (4%) Query: 44 HTKAVSSVKFS----PNGEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAWSS 97 H A+ SV + N E + + S D L+K+W D + + ++ GH+LG+ V S Sbjct: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 + S+S D +++WD+ +GK +K++ + F+P S + +G+ V I+ Sbjct: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 V++GK +L + ++ ++ DG + S + DG+ I+D A+G+ L TL + P+ Sbjct: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPI 193 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK----NEKYC 261 + FSP+ + ++ A+ D +K++D T +GH N +C Sbjct: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC 241 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 14/245 (5%) Query: 77 GKFEKTISGHKLGISDVAWSSD----SNLLVSASDDKTLKIWDVSSGKC-LK-TLKGHSN 130 G K H I VAW ++ S +V+ S D +K+W + L+ +L+GH Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65 Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA--VHFNRDGSLIVS 188 V + + + S S D +R+WD++ GK +K++ A PV A + F+ D + + Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDA--GPVDAWTLAFSPDSQYLAT 123 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 ++ G I+ SG+ +L D + + +SP+GKY+ + +D + ++D + GK Sbjct: 124 GTHVGKVNIFGVESGKKEYSL-DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL 182 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 L T GH + FS + +V+ S+D + I+++Q + L GH V++ A Sbjct: 183 LHTLEGHAMPIRSL--TFS-PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVA 239 Query: 309 CHPTE 313 P + Sbjct: 240 FCPDD 244 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 108/220 (49%), Gaps = 16/220 (7%) Query: 119 GKCLKTLKGHSNYVFCC----NFNPQSNLIVSGSFDESVRIWDVKTGKC-LK-TLPAHSD 172 G K + H + ++ N S +V+GS D+ V++W + + L+ +L H Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF--VKFSPNGKYIL 230 V +V + + SSS D R+WD +G+ +K++ D PV + FSP+ +Y+ Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSI---DAGPVDAWTLAFSPDSQYLA 122 Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 T + ++ GK K Y+ K+ + +S GK++ SG+ D ++ I+++ T Sbjct: 123 TGTHVGKVNIFGVESGK--KEYSLDTRGKFILSIAYS-PDGKYLASGAIDGIINIFDIAT 179 Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +++ L+GH + S P ++ +A+ +D IK++ Sbjct: 180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTAS--DDGYIKIY 217 >5UZ7-B nrPDB Length = 351 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 119/245 (48%), Gaps = 9/245 (3%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWG--AYDG--KFEKTISGHKLGISDVAWSSDSNLLV 103 V + ++P+G ++A D + I+ +G + + ++GH G D N +V Sbjct: 111 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHT-GYLSCCRFLDDNQIV 169 Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163 ++S D T +WD+ +G+ T GH+ V + P + L VSG+ D S ++WDV+ G C Sbjct: 170 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 229 Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVSFVKF 222 +T H ++A+ F +G+ + S D CR++D + Q L T D+ ++ V F Sbjct: 230 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSF 289 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 S +G+ +LA D +WD K GH N C+ G + +GS D+ Sbjct: 290 SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV---TDDGMAVATGSWDSF 346 Query: 283 VYIWN 287 + IWN Sbjct: 347 LKIWN 351 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 110/226 (48%), Gaps = 13/226 (5%) Query: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132 G + +T+ GH I + W +DS LLVSAS D L IWD + + + S++V Sbjct: 52 GRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWV 111 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDGSLIVS 188 C + P N + G D I+++KT + + L H+ +S F D + IV+ Sbjct: 112 MTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVT 170 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 SS D C +WD +GQ T +S + +P+ + ++ D + KLWD +G C Sbjct: 171 SSGDTTCALWDIETGQQTTTFTGHTGDVMS-LSLAPDTRLFVSGACDASAKLWDVREGMC 229 Query: 249 LKTYTGHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 +T+TGH+++ C F N G +GS+D +++L+ + Sbjct: 230 RQTFTGHESDINAICFFPN-----GNAFATGSDDATCRLFDLRADQ 270 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 6/160 (3%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 HT V S+ +P+ S + D K+W +G +T +GH+ I+ + + + N Sbjct: 194 HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA 253 Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFC----CNFNPQSNLIVSGSFDESVRIWDVK 159 + SDD T +++D+ + + L T H N + C +F+ L+++G D + +WD Sbjct: 254 TGSDDATCRLFDLRADQELMTYS-HDN-IICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 311 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 L H + VS + DG + + S+D +IW+ Sbjct: 312 KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 11/170 (6%) Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224 +TL H + A+H+ D L+VS+S DG IWD+ + + I + V ++P Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHA-IPLRSSWVMTCAYAP 118 Query: 225 NGKYILAATLDNTLKLWDY----SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280 +G Y+ LDN +++ + + GH C IV+ S D Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC----RFLDDNQIVTSSGD 174 Query: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +W+++T + GHT V+S + P + S A D + KLW Sbjct: 175 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC--DASAKLW 222 >5I2T-A nrPDB Length = 742 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 86/366 (23%), Positives = 164/366 (44%), Gaps = 85/366 (23%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-----TISGHKLGISDVAWS 96 AGH + ++S+ +S + ++ ++S D KIW + D + EK T +GH+ + +S Sbjct: 168 AGHFQDITSLTWSQDSRFILTTSKDLSAKIW-SVDSE-EKNLAATTFNGHRDYVMGAFFS 225 Query: 97 SDSNLLVSASDDKTLKIWDVS----------------------SGKCLKTLKGHSNY--- 131 D + + S D + +W+ + S + K H Y Sbjct: 226 HDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQ 285 Query: 132 --VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-------- 181 V C F+P + L+ G R++D+ ++ L +PV+ V N+ Sbjct: 286 AKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFG 345 Query: 182 -----------------------------------DGSLIVSSSYDGLCRIWDTASGQCL 206 DGS +V++S DG ++WD SG CL Sbjct: 346 SSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCL 405 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFAN 265 T ++ V+ V+F+ G+ + +++LD T++ WD + + +T+TG + ++ C+ + Sbjct: 406 ATF-EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 464 Query: 266 FSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324 S G+ + +GS DN +++W++QT +++ L GH V + +++ASA+ D Sbjct: 465 PS---GEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASW--D 519 Query: 325 KTIKLW 330 KTI++W Sbjct: 520 KTIRIW 525 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 65/274 (23%), Positives = 130/274 (47%), Gaps = 20/274 (7%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH + +S+ +SP+G + ++S D IK+W G T H ++ V ++ ++ Sbjct: 368 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVM 427 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CCNFNPQSNLIVSGSFDE-SVRIWDVKT 160 S+S D T++ WD+ + +T G F C +P ++ +GS D + +W V+T Sbjct: 428 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT 487 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G+ L L H PVS + F+++ S++ S+S+D RIW + G+ + + V + Sbjct: 488 GQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIW-SIFGRSQQVEPIEVYSDVLAL 546 Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGK------CLK----------TYTGHKNEKYCIFA 264 P+GK + +TL + +++ K C K +T +E+ F Sbjct: 547 SMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFT 606 Query: 265 NFSVT-GGKWIVSGSEDNLVYIWNLQTKEIVQKL 297 + G IV+G +N + ++++ + ++++ Sbjct: 607 TIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRF 640 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 132/298 (44%), Gaps = 49/298 (16%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 P++ L L+ V++V + GEWLA S+ KLG Sbjct: 315 PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS---------------------KLGQLL 353 Query: 93 V-AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 V W S+S +L +GH + ++P + +V+ S D Sbjct: 354 VYEWQSESYILKQ---------------------QGHFDSTNSLAYSPDGSRVVTASEDG 392 Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 +++WD+ +G CL T H+ V+AV F + G ++ SSS DG R WD + +T Sbjct: 393 KIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTG 452 Query: 212 DDNPPVSFVKFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270 + + + P+G+ + A +LDN + +W G+ L +GH+ C+ +FS Sbjct: 453 TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCL--SFS-QE 509 Query: 271 GKWIVSGSEDNLVYIWNLQTK-EIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 + S S D + IW++ + + V+ ++ ++D V++ + P +A + L+ +I Sbjct: 510 NSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISI 566 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 114/241 (47%), Gaps = 25/241 (10%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSD 98 T HT +V++V+F+ G+ + SSS D ++ W + +T +G ++ + +A Sbjct: 407 TFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPS 466 Query: 99 SNLLVSAS-DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 ++ + S D+ + +W V +G+ L L GH V C +F+ +++++ S S+D+++RIW Sbjct: 467 GEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWS 526 Query: 158 VKTGKCLKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------CLKTL 209 + G+ + P +SD V A+ DG + S+ G I++ + C K + Sbjct: 527 I-FGRSQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDI 584 Query: 210 IDDDNPPVSF-------------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 I F + +S +G I+A +N++ L+D LK + + Sbjct: 585 ISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSR 644 Query: 257 N 257 N Sbjct: 645 N 645 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 120/297 (40%), Gaps = 39/297 (13%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS---------GHKLGISDVAWSSDS 99 S+VKFSP+G A +S + ++IW D ++ + GH I+ + WS DS Sbjct: 125 SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDS 183 Query: 100 NLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 +++ S D + KIW V S + T GH +YV F+ I + S D +V +W Sbjct: 184 RFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVW 243 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 + P+ D + ++ + +S W K + Sbjct: 244 E------FTKRPSDDDDNESEDDDKQEEVDISKYS------WRITK----KHFFYANQAK 287 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V V F P + + +L+D ++ + +N + N G+W+ Sbjct: 288 VKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVN---QTGEWLAF 344 Query: 277 GSE---DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 GS LVY W Q++ + K QGH D S A P + + +A+ D IK+W Sbjct: 345 GSSKLGQLLVYEW--QSESYILKQQGHFDSTNSLAYSPDGSRVVTAS--EDGKIKVW 397 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 81/201 (40%), Gaps = 33/201 (16%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L+GH VS + FS LAS+S DK I+IW +I G + + SD Sbjct: 494 LSGHEGPVSCLSFSQENSVLASASWDKTIRIW---------SIFGRSQQVEPIEVYSDVL 544 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-----IVSGSFDESVRI 155 L D K + + TLKG + + N+ I+SG F++ Sbjct: 545 ALSMRPDGKEVAV---------STLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQ---- 591 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 D T K S + +H++ DG IV+ + ++D + LK I N Sbjct: 592 -DRFTAKN----SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNM 646 Query: 216 PVS-FVKFSPNGKYILAATLD 235 ++ ++F + K A +LD Sbjct: 647 ALNGTLEFLNSKKMTEAGSLD 667 >5GAN-H nrPDB Length = 465 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 94/341 (27%), Positives = 148/341 (43%), Gaps = 16/341 (4%) Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVK--PNYALKFTLAGHTKAVSSVKFSPNGE 58 + K+ + E R Q + S+ T ++ N L + TK +S+V S + Sbjct: 129 LERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDM 188 Query: 59 WLASSS-ADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-LLVSASDDKTLKIWDV 116 +A+ S A L + + + H I + W DSN ++S ++D +K + Sbjct: 189 VVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQY 248 Query: 117 SSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 S+ + L L GH + ++P I S S D + R+WD T + L H Sbjct: 249 SNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDK 308 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 V ++ F DGSL+ S D L +WD SG + TL + P+ V +SPNG + Sbjct: 309 GVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGH-SKPIYTVAWSPNGYQVATG 367 Query: 233 TLDNTLKLWDYSKGK--CLKTYTGHKNEKYCIFANFSVT-GGKWIVSGSEDNLVYIWNLQ 289 D + +WD K L H+N FS GGK +VS DNL+ +++ Sbjct: 368 GGDGIINVWDIRKRDEGQLNQILAHRN--IVTQVRFSKEDGGKKLVSCGYDNLINVYSSD 425 Query: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 T + L GHTD +IS + + S D++IKLW Sbjct: 426 TWLKMGSLAGHTDKIISLDISNNSHFLVSGGW--DRSIKLW 464 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 122/257 (47%), Gaps = 15/257 (5%) Query: 41 LAGHTKAVSSVKFSPN-GEWLASSSADKLIK--IWGAYDG--KFEKTISGHKLGISDVAW 95 L H + ++ + P+ + S + D LIK + +G + + GH+ ISDV + Sbjct: 214 LDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKY 273 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 + SAS D T ++WD S+ + L +GH VF +F +L+ SG D + Sbjct: 274 HPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSML 333 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA---SGQCLKTLIDD 212 WD+++G + TL HS P+ V ++ +G + + DG+ +WD GQ + L Sbjct: 334 WDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHR 393 Query: 213 DNPPVSFVKFSPN--GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270 + V+ V+FS GK +++ DN + ++ + + GH ++ I + S Sbjct: 394 N--IVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDK--IISLDIS-NN 448 Query: 271 GKWIVSGSEDNLVYIWN 287 ++VSG D + +WN Sbjct: 449 SHFLVSGGWDRSIKLWN 465 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 69/124 (55%), Gaps = 6/124 (4%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY---DGKFEKTISGHKLGISDVAW 95 TLAGH+K + +V +SPNG +A+ D +I +W +G+ + ++ H+ ++ V + Sbjct: 343 MTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILA-HRNIVTQVRF 401 Query: 96 SSD--SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 S + LVS D + ++ + + +L GH++ + + + S+ +VSG +D S+ Sbjct: 402 SKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSI 461 Query: 154 RIWD 157 ++W+ Sbjct: 462 KLWN 465 >5WLC-LO nrPDB Length = 923 Score = 103 bits (258), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 86/366 (23%), Positives = 164/366 (44%), Gaps = 85/366 (23%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-----TISGHKLGISDVAWS 96 AGH + ++S+ +S + ++ ++S D KIW + D + EK T +GH+ + +S Sbjct: 143 AGHFQDITSLTWSQDSRFILTTSKDLSAKIW-SVDSE-EKNLAATTFNGHRDYVMGAFFS 200 Query: 97 SDSNLLVSASDDKTLKIWDVS----------------------SGKCLKTLKGHSNY--- 131 D + + S D + +W+ + S + K H Y Sbjct: 201 HDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQ 260 Query: 132 --VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-------- 181 V C F+P + L+ G R++D+ ++ L +PV+ V N+ Sbjct: 261 AKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFG 320 Query: 182 -----------------------------------DGSLIVSSSYDGLCRIWDTASGQCL 206 DGS +V++S DG ++WD SG CL Sbjct: 321 SSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCL 380 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFAN 265 T ++ V+ V+F+ G+ + +++LD T++ WD + + +T+TG + ++ C+ + Sbjct: 381 ATF-EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 439 Query: 266 FSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324 S G+ + +GS DN +++W++QT +++ L GH V + +++ASA+ D Sbjct: 440 PS---GEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASW--D 494 Query: 325 KTIKLW 330 KTI++W Sbjct: 495 KTIRIW 500 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 65/274 (23%), Positives = 130/274 (47%), Gaps = 20/274 (7%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH + +S+ +SP+G + ++S D IK+W G T H ++ V ++ ++ Sbjct: 343 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVM 402 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CCNFNPQSNLIVSGSFDE-SVRIWDVKT 160 S+S D T++ WD+ + +T G F C +P ++ +GS D + +W V+T Sbjct: 403 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT 462 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G+ L L H PVS + F+++ S++ S+S+D RIW + G+ + + V + Sbjct: 463 GQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIW-SIFGRSQQVEPIEVYSDVLAL 521 Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGK------CLK----------TYTGHKNEKYCIFA 264 P+GK + +TL + +++ K C K +T +E+ F Sbjct: 522 SMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFT 581 Query: 265 NFSVT-GGKWIVSGSEDNLVYIWNLQTKEIVQKL 297 + G IV+G +N + ++++ + ++++ Sbjct: 582 TIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRF 615 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 132/298 (44%), Gaps = 49/298 (16%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 P++ L L+ V++V + GEWLA S+ KLG Sbjct: 290 PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS---------------------KLGQLL 328 Query: 93 V-AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 V W S+S +L +GH + ++P + +V+ S D Sbjct: 329 VYEWQSESYILKQ---------------------QGHFDSTNSLAYSPDGSRVVTASEDG 367 Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 +++WD+ +G CL T H+ V+AV F + G ++ SSS DG R WD + +T Sbjct: 368 KIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTG 427 Query: 212 DDNPPVSFVKFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270 + + + P+G+ + A +LDN + +W G+ L +GH+ C+ +FS Sbjct: 428 TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCL--SFS-QE 484 Query: 271 GKWIVSGSEDNLVYIWNLQTK-EIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 + S S D + IW++ + + V+ ++ ++D V++ + P +A + L+ +I Sbjct: 485 NSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISI 541 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 114/241 (47%), Gaps = 25/241 (10%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSD 98 T HT +V++V+F+ G+ + SSS D ++ W + +T +G ++ + +A Sbjct: 382 TFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPS 441 Query: 99 SNLLVSAS-DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 ++ + S D+ + +W V +G+ L L GH V C +F+ +++++ S S+D+++RIW Sbjct: 442 GEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWS 501 Query: 158 VKTGKCLKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ------CLKTL 209 + G+ + P +SD V A+ DG + S+ G I++ + C K + Sbjct: 502 I-FGRSQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDI 559 Query: 210 IDDDNPPVSF-------------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 I F + +S +G I+A +N++ L+D LK + + Sbjct: 560 ISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSR 619 Query: 257 N 257 N Sbjct: 620 N 620 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 120/297 (40%), Gaps = 39/297 (13%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS---------GHKLGISDVAWSSDS 99 S+VKFSP+G A +S + ++IW D ++ + GH I+ + WS DS Sbjct: 100 SAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDS 158 Query: 100 NLLVSASDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 +++ S D + KIW V S + T GH +YV F+ I + S D +V +W Sbjct: 159 RFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVW 218 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 + P+ D + ++ + +S W K + Sbjct: 219 E------FTKRPSDDDDNESEDDDKQEEVDISKYS------WRITK----KHFFYANQAK 262 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V V F P + + +L+D ++ + +N + N G+W+ Sbjct: 263 VKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVN---QTGEWLAF 319 Query: 277 GSE---DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 GS LVY W Q++ + K QGH D S A P + + +A+ D IK+W Sbjct: 320 GSSKLGQLLVYEW--QSESYILKQQGHFDSTNSLAYSPDGSRVVTAS--EDGKIKVW 372 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 81/201 (40%), Gaps = 33/201 (16%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L+GH VS + FS LAS+S DK I+IW +I G + + SD Sbjct: 469 LSGHEGPVSCLSFSQENSVLASASWDKTIRIW---------SIFGRSQQVEPIEVYSDVL 519 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-----IVSGSFDESVRI 155 L D K + + TLKG + + N+ I+SG F++ Sbjct: 520 ALSMRPDGKEVAV---------STLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQ---- 566 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 D T K S + +H++ DG IV+ + ++D + LK I N Sbjct: 567 -DRFTAKN----SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNM 621 Query: 216 PVS-FVKFSPNGKYILAATLD 235 ++ ++F + K A +LD Sbjct: 622 ALNGTLEFLNSKKMTEAGSLD 642 >6HHQ-h nrPDB Length = 319 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 72/233 (30%), Positives = 121/233 (51%), Gaps = 18/233 (7%) Query: 37 LKFTLAGHTKAVSSVKFS---PNGEWLASSSADKLIKIW--GAYDGKFE---KTISGHKL 88 L+ TL GH V+S+ S PN L S+S DK + W D KF ++ GH Sbjct: 9 LRGTLEGHNGWVTSLATSAGQPN--LLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSH 66 Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 + D ++D +SAS DKTL++WDV++G+ + GH + V + + ++++I+SGS Sbjct: 67 IVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGS 126 Query: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHF------NRDGSLIVSSSYDGLCRIWDTAS 202 D+++++W +K G+CL TL H+D VS V + D I+S+ D + + W+ Sbjct: 127 RDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQ 185 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 Q I N ++ + SP+G I +A D + LW+ + K + T + Sbjct: 186 FQIEADFI-GHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQ 237 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 69/263 (26%), Positives = 128/263 (48%), Gaps = 17/263 (6%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 + GH+ V + +G + S+S DK +++W G+ + GHK + V + Sbjct: 60 SFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKA 119 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ------SNLIVSGSFDESV 153 ++++S S DKT+K+W + G+CL TL GH+++V P S I+S D+ V Sbjct: 120 SMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMV 178 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 + W++ + H+ ++ + + DG+LI S+ DG +W+ A+ + + TL D Sbjct: 179 KAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQD 238 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLW----DYSKGKCLKTYTGHKN--EKYCIFANFS 267 V + FSPN +Y LAA +K++ Y + G+ E + + +S Sbjct: 239 E--VFSLAFSPN-RYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWS 295 Query: 268 VTGGKWIVSGSEDNLVYIWNLQT 290 G+ + +G DN++ +W + T Sbjct: 296 AD-GQTLFAGYTDNVIRVWQVMT 317 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 103/220 (46%), Gaps = 21/220 (9%) Query: 124 TLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 177 TL+GH+ +V + Q NL++S S D+++ W D K G +++ HS V Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237 DG+ +S+S+D R+WD A+G+ + + + +S V I++ + D T Sbjct: 72 TLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMS-VDIDKKASMIISGSRDKT 130 Query: 238 LKLWDYSKGKCLKTYTGHKN--EKYCIFANF-----SVTGGKWIVSGSEDNLVYIWNLQT 290 +K+W KG+CL T GH + + + N SVT I+S D +V WNL Sbjct: 131 IKVWTI-KGQCLATLLGHNDWVSQVRVVPNEKADDDSVT----IISAGNDKMVKAWNLNQ 185 Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +I GH + + P +IASA D I LW Sbjct: 186 FQIEADFIGHNSNINTLTASPDGTLIASAG--KDGEIMLW 223 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/119 (30%), Positives = 59/119 (49%), Gaps = 16/119 (13%) Query: 224 PNGKYILAATLDNTLKLW-----DYSKGKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSG 277 PN +L+A+ D TL W D G ++++ GH + I + ++T G + +S Sbjct: 30 PN--LLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSH----IVQDCTLTADGAYALSA 83 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW--KSDC 334 S D + +W++ T E Q+ GH V+S ++I S + DKTIK+W K C Sbjct: 84 SWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGS--RDKTIKVWTIKGQC 140 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 28/136 (20%), Positives = 59/136 (43%), Gaps = 10/136 (7%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 + ++ GH ++++ SP+G +AS+ D I +W K T+S S + Sbjct: 185 QFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFS-L 243 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSN----YVFCCNFNPQSNLIV 145 A+S + L +A+ +K++ + + L+ G+S + ++ + Sbjct: 244 AFSPNRYWLAAAT-ATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLF 302 Query: 146 SGSFDESVRIWDVKTG 161 +G D +R+W V T Sbjct: 303 AGYTDNVIRVWQVMTA 318 >5WYK-BB nrPDB Length = 943 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 56/162 (34%), Positives = 87/162 (53%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS 104 T + V+ SP+ +LA S D +K++ KF ++ GHKL + + S DS ++++ Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIIT 590 Query: 105 ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164 +S DK +KIW + G C K+L H + + F PQS+ S S D V+ WD + +C+ Sbjct: 591 SSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECI 650 Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 + L AH V A+ DG +VSSS+D RIW+ Q Sbjct: 651 QKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVF 692 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 65/253 (25%), Positives = 114/253 (45%), Gaps = 21/253 (8%) Query: 52 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLLVSASDDKT 110 KF P G + + + ++++ TI H I + +SD LV+ S DKT Sbjct: 437 KFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKT 496 Query: 111 LKIWDV---------SSGKCLKTLKGH-------SNYVFCCNFNPQSNLIVSGSFDESVR 154 +K WD + K L LK H ++ + C +P + D +V+ Sbjct: 497 VKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVK 556 Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 ++ + + K +L H PV ++ + D +I++SS D +IW G C K+L + Sbjct: 557 VFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQD 616 Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274 ++ VKF P + + D +K WD K +C++ H++E ++A T G ++ Sbjct: 617 SIMN-VKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSE---VWALAVATDGGFV 672 Query: 275 VSGSEDNLVYIWN 287 VS S D+ + IW Sbjct: 673 VSSSHDHSIRIWE 685 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 24/267 (8%) Query: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142 + G + + + S D+ LL +AS+ +LKIW++ + KC++T + Y C F P Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASNG-SLKIWNIKTHKCIRTFE--CGYALTCKFLPGGL 443 Query: 143 LIVSGSFDESVRIWDVKTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 L++ G+ + ++++D+ + L T+ AH + ++ DG +V+ S D + WD Sbjct: 444 LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFK 503 Query: 202 SGQCLKTLIDDDNPPVS---------------FVKFSPNGKYILAATLDNTLKLWDYSKG 246 L + PV V+ SP+ +Y+ + LDNT+K++ Sbjct: 504 VENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSM 563 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 K + GHK I +F K I++ S D + IW L + + L H D +++ Sbjct: 564 KFYLSLYGHKLPVLSIDISFD---SKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMN 620 Query: 307 TACHPTENIIASAALENDKTIKLWKSD 333 P + S + D +K W + Sbjct: 621 VKFLPQSHNFFSCS--KDAVVKYWDGE 645 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 107/223 (47%), Gaps = 17/223 (7%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWG---------AYDGKFEKTISGHK---LGI 90 H A+ S+ + +G+ L + SADK +K W KF + H L + Sbjct: 471 AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL 530 Query: 91 SD----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 +D V S D L + D T+K++ + S K +L GH V + + S +I++ Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIIT 590 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 S D++++IW + G C K+L AH D + V F S S D + + WD +C+ Sbjct: 591 SSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECI 650 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 + L + V + + +G ++++++ D+++++W+ ++ + Sbjct: 651 QKLYAHQS-EVWALAVATDGGFVVSSSHDHSIRIWEETEDQVF 692 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 42/124 (33%), Positives = 65/124 (52%), Gaps = 2/124 (1%) Query: 36 ALKF--TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 ++KF +L GH V S+ S + + + +SSADK IKIWG G K++ H+ I +V Sbjct: 562 SMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNV 621 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 + S+ S S D +K WD +C++ L H + V+ +VS S D S+ Sbjct: 622 KFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSI 681 Query: 154 RIWD 157 RIW+ Sbjct: 682 RIWE 685 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 46/195 (23%), Positives = 86/195 (44%), Gaps = 21/195 (10%) Query: 151 ESVRIWDVKTGKCLKTL-----PAHSDPVSA-------VHFNRDGSLIVSSSYDGLCRIW 198 E V IWD+KTG + L P SD A + ++D L+ DG+ ++W Sbjct: 47 EDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVW 106 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 D S L + ++ ++F G +++ + D+ + +WD L HK+ Sbjct: 107 DLMSKTVLLNF-NGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDS 165 Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318 F G W++S S+D ++ +W+L+T + ++ HT A ++++ + Sbjct: 166 ----ITGFWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVK--DDLLIT 219 Query: 319 AALENDKTIKLWKSD 333 D +K+WK D Sbjct: 220 TG--TDSQVKIWKLD 232 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%) Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 D++LL D +K+WD+ S L GH + F+ ++SGS D ++ +WD Sbjct: 90 DTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWD 149 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 + L L +H D ++ + LI S+S DG+ ++WD + QC++T I Sbjct: 150 LVGEVGLYKLRSHKDSITGFWCQGEDWLI-STSKDGMIKLWDLKTHQCIETHI 201 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 68/141 (48%), Gaps = 7/141 (4%) Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119 LA AD +IK+W +GHK I+ + + L+S S D + +WD+ Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGE 153 Query: 120 KCLKTLKGHSNYV--FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177 L L+ H + + F C + ++S S D +++WD+KT +C++T AH+ + Sbjct: 154 VGLYKLRSHKDSITGFWCQ---GEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGL 210 Query: 178 HFNRDGSLIVSSSYDGLCRIW 198 D L++++ D +IW Sbjct: 211 AVKDD--LLITTGTDSQVKIW 229 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 3/114 (2%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH A++ ++F G L S S D I +W + HK I+ W + L Sbjct: 119 GHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGF-WCQGEDWL 177 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 +S S D +K+WD+ + +C++T H+ C + +L+++ D V+IW Sbjct: 178 ISTSKDGMIKLWDLKTHQCIETHIAHTGE--CWGLAVKDDLLITTGTDSQVKIW 229 >3MKQ-A nrPDB Length = 814 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 77/290 (26%), Positives = 138/290 (47%), Gaps = 11/290 (3%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAW 95 +K T + + V + F P W+ ++ ++IW Y+ + E ++I + + + Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWN-YETQVEVRSIQVTETPVRAGKF 63 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 + N ++ SDD +++++ ++G+ + + H +Y+ +P ++SGS D +V++ Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 156 WDVKTGKCL-KTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 W+ + L +T H V V FN +D S S D ++W TL Sbjct: 124 WNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ 183 Query: 214 NPPVSFVKFS--PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 V++V + P+ Y++ A+ D T+K+WDY C+ T GH + FA F T Sbjct: 184 ERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSN--VSFAVFHPT-L 240 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT--ENIIASA 319 I+SGSED + IWN T ++ + L + A HPT +N IAS Sbjct: 241 PIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 127/286 (44%), Gaps = 8/286 (2%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 V + KF W+ S D I+++ G+ H I +A ++S SD Sbjct: 58 VRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSD 117 Query: 108 DKTLKIWDVSSGKCL-KTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLK 165 D T+K+W+ + L +T +GH ++V C FNP+ + SG D +V++W + Sbjct: 118 DLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNF 177 Query: 166 TL-PAHSDPVSAVHFN--RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 TL V+ V + D ++++S D +IWD + C+ TL + VSF F Sbjct: 178 TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL-EGHMSNVSFAVF 236 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 P I++ + D TLK+W+ S K KT +CI + TG K ++ DN Sbjct: 237 HPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATH--PTGRKNYIASGFDNG 294 Query: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328 + +L E L +V S + + I +A + ++ ++ Sbjct: 295 FTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVE 340 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 51/139 (36%), Positives = 78/139 (56%), Gaps = 6/139 (4%) Query: 34 NYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGI 90 N+AL+ T GH V V F+P + AS D+ +K+W G F T +G + G+ Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT-TGQERGV 187 Query: 91 SDVAWSS--DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 + V + D +++ASDD T+KIWD + C+ TL+GH + V F+P +I+SGS Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGS 247 Query: 149 FDESVRIWDVKTGKCLKTL 167 D +++IW+ T K KTL Sbjct: 248 EDGTLKIWNSSTYKVEKTL 266 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 103/223 (46%), Gaps = 3/223 (1%) Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170 ++IW+ + +++++ V F + N I+ GS D +R+++ TG+ + AH Sbjct: 37 VEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAH 96 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 D + ++ + ++S S D ++W+ + L+ + V V F+P Sbjct: 97 PDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTF 156 Query: 231 AAT-LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 A+ LD T+K+W + T T + + + ++++ S+D + IW+ Q Sbjct: 157 ASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQ 216 Query: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 TK V L+GH V HPT II S + D T+K+W S Sbjct: 217 TKSCVATLEGHMSNVSFAVFHPTLPIIISGS--EDGTLKIWNS 257 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 55/114 (48%), Gaps = 5/114 (4%) Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V + F P ++L +++W+Y +++ + + + A + WI+ Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSI---QVTETPVRAGKFIARKNWIIV 72 Query: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 GS+D + ++N T E V + H D + S A HPT+ + S + +D T+KLW Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS--DDLTVKLW 124 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Query: 33 PNYALKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90 PN+ L G + V+ V + P + ++ ++S D IKIW T+ GH + Sbjct: 175 PNFTLT---TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNV 231 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP--QSNLIVSGS 148 S + +++S S+D TLKIW+ S+ K KTL +C +P + N I SG Sbjct: 232 SFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG- 290 Query: 149 FDESVRI 155 FD + Sbjct: 291 FDNGFTV 297 >2YNP-A nrPDB Length = 604 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 138/290 (47%), Gaps = 11/290 (3%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAW 95 +K T + + V + F P W+ ++ +++W Y+ + E ++I + + + Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWN-YETQVEVRSIQVTETPVRAGKF 63 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 + N ++ SDD +++++ ++G+ + + H +Y+ +P ++SGS D +V++ Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 156 WDVKTGKCL-KTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 W+ + L +T H V V FN +D S S D ++W TL Sbjct: 124 WNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ 183 Query: 214 NPPVSFVKFS--PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 V++V + P+ Y++ A+ D T+K+WDY C+ T GH + FA F T Sbjct: 184 ERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSN--VSFAVFHPT-L 240 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT--ENIIASA 319 I+SGSED + IWN T ++ + L + A HPT +N IAS Sbjct: 241 PIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 128/286 (44%), Gaps = 8/286 (2%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 V + KF W+ S D I+++ G+ H I +A ++S SD Sbjct: 58 VRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSD 117 Query: 108 DKTLKIWDVSSGKCL-KTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLK 165 D T+K+W+ + L +T +GH ++V C FNP+ + SG D +V++W + Sbjct: 118 DLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNF 177 Query: 166 TLPAHSDP-VSAVHFN--RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 TL + V+ V + D ++++S D +IWD + C+ TL + VSF F Sbjct: 178 TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL-EGHMSNVSFAVF 236 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 P I++ + D TLK+W+ S K KT +CI + TG K ++ DN Sbjct: 237 HPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATH--PTGRKNYIASGFDNG 294 Query: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328 + +L E L +V S + + I +A + ++ ++ Sbjct: 295 FTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVE 340 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 51/139 (36%), Positives = 78/139 (56%), Gaps = 6/139 (4%) Query: 34 NYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGI 90 N+AL+ T GH V V F+P + AS D+ +K+W G F T +G + G+ Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT-TGQERGV 187 Query: 91 SDVAWSS--DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 + V + D +++ASDD T+KIWD + C+ TL+GH + V F+P +I+SGS Sbjct: 188 NYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGS 247 Query: 149 FDESVRIWDVKTGKCLKTL 167 D +++IW+ T K KTL Sbjct: 248 EDGTLKIWNSSTYKVEKTL 266 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 103/223 (46%), Gaps = 3/223 (1%) Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170 +++W+ + +++++ V F + N I+ GS D +R+++ TG+ + AH Sbjct: 37 VELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAH 96 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 D + ++ + ++S S D ++W+ + L+ + V V F+P Sbjct: 97 PDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTF 156 Query: 231 AAT-LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 A+ LD T+K+W + T T + + + ++++ S+D + IW+ Q Sbjct: 157 ASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQ 216 Query: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 TK V L+GH V HPT II S + D T+K+W S Sbjct: 217 TKSCVATLEGHMSNVSFAVFHPTLPIIISGS--EDGTLKIWNS 257 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 5/111 (4%) Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279 + F P ++L ++LW+Y +++ + + + A + WI+ GS+ Sbjct: 19 IDFHPTEPWVLTTLYSGRVELWNYETQVEVRSI---QVTETPVRAGKFIARKNWIIVGSD 75 Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 D + ++N T E V + H D + S A HPT+ + S + +D T+KLW Sbjct: 76 DFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS--DDLTVKLW 124 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/127 (29%), Positives = 60/127 (47%), Gaps = 8/127 (6%) Query: 33 PNYALKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90 PN+ L G + V+ V + P + ++ ++S D IKIW T+ GH + Sbjct: 175 PNFTLT---TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNV 231 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP--QSNLIVSGS 148 S + +++S S+D TLKIW+ S+ K KTL +C +P + N I SG Sbjct: 232 SFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG- 290 Query: 149 FDESVRI 155 FD + Sbjct: 291 FDNGFTV 297 >6N9G-C nrPDB Length = 353 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 118/249 (47%), Gaps = 14/249 (5%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSNL 101 V + ++P+G +A D ++ K E K+++ H +S ++++ Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQ 167 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSGSFDESVRIWDVK 159 +++AS D T +WDV SG+ L++ GH V C + P N VSG D+ +WD++ Sbjct: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR 227 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVS 218 +G+C++ H V++V + G S S D CR++D + + + + S Sbjct: 228 SGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGAS 287 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT-GGKWIVSG 277 V FS +G+ + A D T+ +WD KG + GH+N + V+ G SG Sbjct: 288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENR----VSTLRVSPDGTAFCSG 343 Query: 278 SEDNLVYIW 286 S D+ + +W Sbjct: 344 SWDHTLRVW 352 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 102/210 (48%), Gaps = 5/210 (2%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDV 93 A K ++A HT +S+ F+ + + ++S D +W G+ ++ GH + D+ Sbjct: 144 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 A S N VS DK +WD+ SG+C++ + H + V + P + SGS D + Sbjct: 204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATC 263 Query: 154 RIWDVKTGKCLKTLPAHSD--PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 R++D++ + + S S+V F+ G L+ + D +WD G + L Sbjct: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 323 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 +N VS ++ SP+G + + D+TL++W Sbjct: 324 HEN-RVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/315 (21%), Positives = 129/315 (40%), Gaps = 60/315 (19%) Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD------------- 115 ++ G + K +T+ GH + + W D +VS+S D + +WD Sbjct: 45 VEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMP 104 Query: 116 ---------------VSSG----KC----------------LKTLKGHSNYVFCCNFNPQ 140 ++ G KC K++ H+NY+ C+F Sbjct: 105 CTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164 Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIW 198 I++ S D + +WDV++G+ L++ H V + + G+ VS D +W Sbjct: 165 DMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 D SGQC++ + V+ V++ P+G + + D T +L+D + + Y+ + Sbjct: 225 DMRSGQCVQAF-ETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS----K 279 Query: 259 KYCIFANFSV---TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315 + IF SV G+ + +G D + +W++ V L GH + V + P Sbjct: 280 ESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTA 339 Query: 316 IASAALENDKTIKLW 330 S + D T+++W Sbjct: 340 FCSGSW--DHTLRVW 352 >5G04-R nrPDB Length = 499 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 124/278 (44%), Gaps = 21/278 (7%) Query: 66 DKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK 123 D + +W A G + + + G IS VAW + N L + +++WDV K L+ Sbjct: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 262 Query: 124 TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRD 182 + HS V ++N S ++ SGS + DV+ + + TL HS V + + D Sbjct: 263 NMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 Query: 183 GSLIVSSSYDGLCRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKYILA---ATLD 235 G + S D L +W +A G+ L+T V V + P +LA T D Sbjct: 321 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSD 379 Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEI 293 +++W+ G CL H +++ K ++SG N + IW T Sbjct: 380 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAK 435 Query: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 V +L+GHT V+S P +ASAA D+T++LW+ Sbjct: 436 VAELKGHTSRVLSLTMSPDGATVASAAA--DETLRLWR 471 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 10/168 (5%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE----KTISGHKLGISDVAW 95 TL+GH++ V ++++P+G LAS D L+ +W + G+ +T + H+ + VAW Sbjct: 304 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 Query: 96 SS-DSNLLVS--ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS--FD 150 SN+L + + D+ ++IW+V SG CL + HS V ++P ++SG Sbjct: 364 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 422 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + IW T + L H+ V ++ + DG+ + S++ D R+W Sbjct: 423 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76 P A L GHT V S+ SP+G +AS++AD+ +++W ++ Sbjct: 431 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 474 >4GGA-A nrPDB Length = 420 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 89/326 (27%), Positives = 144/326 (44%), Gaps = 23/326 (7%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 TP SS + P P+ L + ++ V +S +G LA + D + +W A G Sbjct: 78 TPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSG 135 Query: 78 KFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135 + + + G IS VAW + N L + +++WDV K L+ + HS V Sbjct: 136 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 195 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194 ++N S ++ SGS + DV+ + + TL HS V + + DG + S D L Sbjct: 196 SWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 253 Query: 195 CRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGK 247 +W +A G+ L+T V V + P +LA T D +++W+ G Sbjct: 254 VNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 312 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDVVI 305 CL H +++ K ++SG N + IW T V +L+GHT V+ Sbjct: 313 CLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 368 Query: 306 STACHPTENIIASAALENDKTIKLWK 331 S P +ASAA D+T++LW+ Sbjct: 369 SLTMSPDGATVASAAA--DETLRLWR 392 Score = 35.8 bits (81), Expect = 0.025, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76 P A L GHT V S+ SP+G +AS++AD+ +++W ++ Sbjct: 352 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 395 >5LCW-Q nrPDB Length = 374 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 89/326 (27%), Positives = 144/326 (44%), Gaps = 23/326 (7%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 TP SS + P P+ L + ++ V +S +G LA + D + +W A G Sbjct: 32 TPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSG 89 Query: 78 KFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135 + + + G IS VAW + N L + +++WDV K L+ + HS V Sbjct: 90 DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSL 149 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194 ++N S ++ SGS + DV+ + + TL HS V + + DG + S D L Sbjct: 150 SWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNL 207 Query: 195 CRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGK 247 +W +A G+ L+T V V + P +LA T D +++W+ G Sbjct: 208 VNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGA 266 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDVVI 305 CL H +++ K ++SG N + IW T V +L+GHT V+ Sbjct: 267 CLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 322 Query: 306 STACHPTENIIASAALENDKTIKLWK 331 S P +ASAA D+T++LW+ Sbjct: 323 SLTMSPDGATVASAAA--DETLRLWR 346 Score = 35.8 bits (81), Expect = 0.025, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76 P A L GHT V S+ SP+G +AS++AD+ +++W ++ Sbjct: 306 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 349 >4N14-A nrPDB Length = 314 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 124/278 (44%), Gaps = 21/278 (7%) Query: 66 DKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK 123 D + +W A G + + + G IS VAW + N L + +++WDV K L+ Sbjct: 40 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 99 Query: 124 TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRD 182 + HS V ++N S ++ SGS + DV+ + + TL HS V + + D Sbjct: 100 NMTSHSARVGSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 157 Query: 183 GSLIVSSSYDGLCRIWDTASGQC----LKTLIDDDNPPVSFVKFSPNGKYILA---ATLD 235 G + S D L +W +A G+ L+T V V + P +LA T D Sbjct: 158 GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQG-AVKAVAWCPWQSNVLATGGGTSD 216 Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEI 293 +++W+ G CL H +++ K ++SG N + IW T Sbjct: 217 RHIRIWNVCSGACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAK 272 Query: 294 VQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 V +L+GHT V+S P +ASAA D+T++LW+ Sbjct: 273 VAELKGHTSRVLSLTMSPDGATVASAAA--DETLRLWR 308 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 10/168 (5%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE----KTISGHKLGISDVAW 95 TL+GH++ V ++++P+G LAS D L+ +W + G+ +T + H+ + VAW Sbjct: 141 TLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 200 Query: 96 SS-DSNLLVS--ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS--FD 150 SN+L + + D+ ++IW+V SG CL + HS V ++P ++SG Sbjct: 201 CPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHGFAQ 259 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + IW T + L H+ V ++ + DG+ + S++ D R+W Sbjct: 260 NQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 35.4 bits (80), Expect = 0.031, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76 P A L GHT V S+ SP+G +AS++AD+ +++W ++ Sbjct: 268 PTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFE 311 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 39/76 (51%), Gaps = 1/76 (1%) Query: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 +LA LDN++ LW S G L+ + +Y I + + G ++ G+ V +W++ Sbjct: 34 VLAVALDNSVYLWSASSGDILQLLQMEQPGEY-ISSVAWIKEGNYLAVGTSSAEVQLWDV 92 Query: 289 QTKEIVQKLQGHTDVV 304 Q ++ ++ + H+ V Sbjct: 93 QQQKRLRNMTSHSARV 108 >5NZU-C nrPDB Length = 905 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 71/301 (23%), Positives = 131/301 (43%), Gaps = 8/301 (2%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 +K L + V SV P W+ +S + + +W KT L + + Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + N +V+ +DD +++++ ++ + + + HS+Y+ C +P I++ S D +++W Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 Query: 157 D-VKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 D K C + H+ V + N +D + S+S D ++W S TL + Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL-EGHE 185 Query: 215 PPVSFVKFSPNGK--YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 V+ + + G Y+++ D +K+WDY C++T GH C A+F Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSC--ASFH-PELP 242 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 I++GSED V IW+ T + L + V A N +A E +KL + Sbjct: 243 IIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGRE 302 Query: 333 D 333 + Sbjct: 303 E 303 >3FM0-A nrPDB Length = 345 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 85/316 (26%), Positives = 143/316 (45%), Gaps = 40/316 (12%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTI--SGHKLGISDVAWSSDSNLLVSASD 107 + ++P G LAS D+ I+IWG D K++ GH+ + VAWS N L SAS Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 108 DKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG---K 162 D T IW + +C+ TL+GH N V + P NL+ + S D+SV +W+V + Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNPPVSFV 220 C+ L +H+ V V ++ L+ S+SYD +++ C TL + V + Sbjct: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL-EGHESTVWSL 200 Query: 221 KFSPNGKYILAATLDNTLKLW-DYSKG--------------KCLKTYTGHKNEKYCIFAN 265 F P+G+ + + + D T+++W Y G KC+ T +G + A Sbjct: 201 AFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK---------LQGHTDVVISTACHPTE-NI 315 +TG + + D+ + ++ Q+ Q H+ V A +P E + Sbjct: 261 CQLTGA--LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGL 318 Query: 316 IASAALENDKTIKLWK 331 +AS + +D + WK Sbjct: 319 LASCS--DDGEVAFWK 332 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 53/163 (32%), Positives = 83/163 (50%), Gaps = 7/163 (4%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSN 100 GH + V V +SP G +LAS+S D IW FE T+ GH+ + VAW+ N Sbjct: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118 Query: 101 LLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 LL + S DK++ +W+V +C+ L H+ V ++P L+ S S+D++V+++ Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178 Query: 158 VKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + C TL H V ++ F+ G + S S D RIW Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 5/122 (4%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-YDGKFE--KTISGHKLGISDVAWS 96 TL GH V SV ++P+G LA+ S DK + +W + ++E ++ H + V W Sbjct: 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWH 159 Query: 97 SDSNLLVSASDDKTLKIWDVSSGK--CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 LL SAS D T+K++ C TL+GH + V+ F+P + S S D +VR Sbjct: 160 PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVR 219 Query: 155 IW 156 IW Sbjct: 220 IW 221 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 44/143 (30%), Positives = 64/143 (44%), Gaps = 26/143 (18%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---------------TIS 84 TL GH V S+ F P+G+ LAS S D+ ++IW Y E+ T+S Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248 Query: 85 G-HKLGISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKCLKTL-------KGHSNYVFC 134 G H I D+AW + L +A D ++++ D +S T + HS V C Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308 Query: 135 CNFNP-QSNLIVSGSFDESVRIW 156 +NP + L+ S S D V W Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 28/193 (14%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGIS 91 Y L HT+ V V + P+ E LAS+S D +K++ + + T+ GH+ + Sbjct: 139 EYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVW 198 Query: 92 DVAWSSDSNLLVSASDDKTLKIWDV---------------SSGKCLKTLKG-HSNYVFCC 135 +A+ L S SDD+T++IW S KC+ TL G HS ++ Sbjct: 199 SLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDI 258 Query: 136 NFNPQSNLIVSGSFDESVRIW--DVKTGKCLKTL-------PAHSDPVSAVHFN-RDGSL 185 + + + + D+++R++ D + T AHS V+ V +N ++ L Sbjct: 259 AWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGL 318 Query: 186 IVSSSYDGLCRIW 198 + S S DG W Sbjct: 319 LASCSDDGEVAFW 331 >4BTS-AR nrPDB Length = 343 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 108/228 (47%), Gaps = 29/228 (12%) Query: 41 LAGHTKAVSSV------KFSPNGEWLASSSADKLIKIWGAYD----GKF---EKTISGHK 87 L GH+ V+S+ K + + L S S DK + IW Y+ G F K ++GH Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 +SD+A S ++ +S+S DKTL++WD+ +G K GH + V+ F+P + I+S Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSA 136 Query: 148 SFDESVRIWDVKTGKCLKTLPA---HSDPVSAVHF----------NRDGSLIVSSSYDGL 194 + +++W++ G+C + HSD VS V + S +DG Sbjct: 137 GAEREIKLWNI-LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGR 195 Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 ++W+T ++ V+ + SPNGKYI D L +WD Sbjct: 196 LKVWNT--NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWD 241 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 107/213 (50%), Gaps = 26/213 (12%) Query: 96 SSDSNLLVSASDDKTLKIWDVSS-------GKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 + DS +L+S S DKT+ IW + G K L GH+++V + ++ +S S Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSS 95 Query: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208 +D+++R+WD++TG K H V +V F+ D I+S+ + ++W+ G+C + Sbjct: 96 WDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNIL-GECKFS 154 Query: 209 LIDDDNPP--VSFVKFSPNGK----------YILAATLDNTLKLWDYSKGKCLKTYTGHK 256 + +N VS V++SP K Y + D LK+W+ + + T+ H+ Sbjct: 155 SAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWN-TNFQIRYTFKAHE 213 Query: 257 NEKYCIFANFSVT-GGKWIVSGSEDNLVYIWNL 288 + + S++ GK+I +G +D + IW++ Sbjct: 214 SN----VNHLSISPNGKYIATGGKDKKLLIWDI 242 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 66/151 (43%), Gaps = 19/151 (12%) Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAV------HFNRDGSLIVSSSYDGLCRIWDTASG 203 + S+ I VK G L HSD V+++ N D +++S S D IW Sbjct: 4 NSSLDIQVVKRG----ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEE 59 Query: 204 Q------CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257 + + N VS + S + ++++ D TL+LWD G K + GH++ Sbjct: 60 EQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQS 119 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 E Y + FS + I+S + + +WN+ Sbjct: 120 EVYSV--AFS-PDNRQILSAGAEREIKLWNI 147 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 19/133 (14%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISD-VAWSSD 98 GH V SV FSP+ + S+ A++ IK+W + KF S K SD V+ Sbjct: 114 FVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFS---SAEKENHSDWVSCVRY 170 Query: 99 SNLLVSASD-------------DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 S ++ SA+ D LK+W+ ++ + T K H + V + +P I Sbjct: 171 SPIMKSANKVQPFAPYFASVGWDGRLKVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIA 229 Query: 146 SGSFDESVRIWDV 158 +G D+ + IWD+ Sbjct: 230 TGGKDKKLLIWDI 242 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 13/39 (33%), Positives = 24/39 (61%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72 N+ +++T H V+ + SPNG+++A+ DK + IW Sbjct: 202 NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIW 240 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 20/56 (35%), Positives = 28/56 (50%), Gaps = 2/56 (3%) Query: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +S S D + +W+L+T ++ GH V S A P I SA E + IKLW Sbjct: 92 ISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAE--REIKLW 145 >5FVM-C nrPDB Length = 303 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 114/234 (48%), Gaps = 27/234 (11%) Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 + GHK ++ +A+ ++ +VS+S+D T+K+WDV S + K H+ V +P Sbjct: 70 SFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQ 128 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 ++S D ++RIWD+ +C L P + P+ ++ DGS++V+ + G C +W Sbjct: 129 GELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRM 188 Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL------------DNTLKLWDYSKGKC 248 TL PV+ KF + KYI L D+T ++W+ Sbjct: 189 PHHTDASTL-----EPVT--KFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQ 241 Query: 249 LKT-YTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300 L+T GH+ + C F+ S ++V+ D+ V +W+L T EIV++ GH Sbjct: 242 LETTLDGHQRWVWDCAFSADSA----YLVTACSDHYVRLWDLSTSEIVRQYGGH 291 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 107/247 (43%), Gaps = 15/247 (6%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 + P PV + GH V+S+ F W+ SSS D IK+W ++ Sbjct: 63 NNPNPVS-------SFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK- 114 Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY-VFCCNFNPQSNLI 144 H +++VA + L+S D ++IWD+ +C L N + + +++ Sbjct: 115 HNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSML 174 Query: 145 VSGSFDESVRIW------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 V+G+ + +W D T + + +H+ ++ V + D + + S D R+W Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVW 234 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 + L+T +D V FS + Y++ A D+ ++LWD S + ++ Y GH Sbjct: 235 NIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKG 294 Query: 259 KYCIFAN 265 C+ N Sbjct: 295 AVCVALN 301 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 105/239 (43%), Gaps = 17/239 (7%) Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 +L SA D T++ W+ +G C +T++ + V + + VR++D+++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIRS 62 Query: 161 G--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 + + H V+++ F ++ +VSSS DG ++WD S + N PV+ Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNY--KHNAPVN 120 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSG 277 V PN +++ D +++WD + +C T N + SV + G +V+G Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTP---LQSLSVASDGSMLVAG 177 Query: 278 SEDNLVYIWNL------QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 + Y+W + T E V K + HT + T + ++ A D T ++W Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYI--TRVLLSADVKNLATCSADHTARVW 234 >5OQL-L nrPDB Length = 557 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 107/199 (53%), Gaps = 11/199 (5%) Query: 52 KFSPNGEWLASSSADKLIKIWGAYDGK---FEKTISGHKLGISDVAWS-SDSNLLVSASD 107 + P+G L + ++++ G KT HK + WS ++ L+S SD Sbjct: 106 EIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSD 165 Query: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIWDVKT-GKC 163 DKT+++WD+ S + GH++YV C F P SNL+VSGS+DE+VR+WD + G Sbjct: 166 DKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGA 225 Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 + T H+DP+ V G+ ++++S + + + D + + L+ LI + V+ + + Sbjct: 226 VMTF-KHADPIEDVLPLPSGTTLLAASGNAIS-VLDLVAAKPLR-LITNHQKTVTSLSLA 282 Query: 224 PNGKYILAATLDNTLKLWD 242 G+ +++ +LD +K+++ Sbjct: 283 SQGRRVVSGSLDGHVKVFE 301 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 56/259 (21%) Query: 79 FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138 F ++ L S + ++ +N L + + ++I+ + + LKT+ + C Sbjct: 49 FPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIR 108 Query: 139 PQSNLIVSG----------------------------------------------SFDES 152 P ++V+G S D++ Sbjct: 109 PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHF---NRDGSLIVSSSYDGLCRIWDT-ASGQCLKT 208 VR+WD+ + + H+D V F + + +L+VS SYD R+WD A G + T Sbjct: 169 VRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMT 228 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 D P+ V P+G +LAA+ N + + D K L+ T H+ + + Sbjct: 229 FKHAD--PIEDVLPLPSGTTLLAAS-GNAISVLDLVAAKPLRLITNHQK---TVTSLSLA 282 Query: 269 TGGKWIVSGSEDNLVYIWN 287 + G+ +VSGS D V ++ Sbjct: 283 SQGRRVVSGSLDGHVKVFE 301 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 58/116 (50%), Gaps = 10/116 (8%) Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 + P+G+ ++A ++++D +G LKT+ HK + +S T ++S Sbjct: 106 EIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWV--TKWSPTELTTLMSC 163 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP---TENIIASAALENDKTIKLW 330 S+D V +W+L + + + GHTD V A P N++ S + D+T+++W Sbjct: 164 SDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSY--DETVRVW 217 >6J6H-n nrPDB Length = 455 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/291 (25%), Positives = 132/291 (45%), Gaps = 16/291 (5%) Query: 43 GHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSN 100 GH + +++KF P G + S D IKIW Y D + + GH I + ++ D Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 +S+S D+++KIWD +GK L +S + + + G + + +D + Sbjct: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 Query: 161 GK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 + ++T H + A+ + DGS +SSS D RIW+ +K + D + Sbjct: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYS-----KGKCLKTYTGHKNEKYCIFANFSVTGGK 272 F+ P+ Y A ++DN +++ +S K K + GH + Y I FS G+ Sbjct: 340 PFLNVHPSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS-GDGR 396 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC-HPTE--NIIASAA 320 +I SG + ++ W+ T ++ ++ + I+ HP E +I S A Sbjct: 397 YICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGA 447 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 20/150 (13%) Query: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90 V N L T H ++ ++K+ P+G SSS DK ++IW E I+ I Sbjct: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-------ENQINVPIKQI 331 Query: 91 SDVAWSS--------DSNLLVSASDDKTLKIWDVS---SGKCLKTLKGHSN--YVFCCNF 137 SD A S N + S D + + + K KGHS+ Y F Sbjct: 332 SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF 391 Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 + I SG + WD T + L + Sbjct: 392 SGDGRYICSGDSKSRLFTWDWNTSRLLNNI 421 >4V7E-Bg nrPDB Length = 380 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 66/277 (23%), Positives = 125/277 (45%), Gaps = 20/277 (7%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 TL GH+ V S+ ++P W+ S+S D + +W A + I H + + A++ + Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNG 120 Query: 100 NLLVSASDDKTLKIWDVSSGK-------CLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDE 151 + D I+++SS + L GH Y C + P Q +++GS D+ Sbjct: 121 QSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQ 180 Query: 152 SVRIWDVKTGKCLKTL-----PAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWD-TASGQ 204 + +WDV TG+ + H+ V ++ N + ++ +S S D R+WD + + Sbjct: 181 TCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSR 240 Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT----GHKNEKY 260 ++T + ++ VKF P+G+ + D T +L+D G L+ Y + NE Sbjct: 241 AVRTYHGHEG-DINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELP 299 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 297 + + G+ + +G + Y+W+ E+V L Sbjct: 300 IVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNL 336 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 107/229 (46%), Gaps = 18/229 (7%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTI-----SGHK 87 N + L GH SS ++ P+ E L + S D+ +W G+ SGH Sbjct: 146 NMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHT 205 Query: 88 LGISDVAWSS-DSNLLVSASDDKTLKIWDVS-SGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 + ++ +S ++N+ +S S D T+++WD+ + + ++T GH + F P Sbjct: 206 ADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFG 265 Query: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDP-------VSAVHFNRDGSLIVSSSYDGLCRIW 198 +GS D + R++D++TG L+ D V++V F+ G L+ + +G C +W Sbjct: 266 TGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVW 325 Query: 199 DTASGQC---LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244 DT + L TL + +S + S +G + + D LK+W +S Sbjct: 326 DTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 52/230 (22%), Positives = 105/230 (45%), Gaps = 19/230 (8%) Query: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140 +T+ GH + + W+ + N +VSAS D L +W+ + + +K H +V C F P Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 141 SNLIVSGSFDESVRIWDVKTGK-------CLKTLPAHSDPVSAVHFNRDG-SLIVSSSYD 192 + G D + I+++ + + L H S+ + D + +++ S D Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGD 179 Query: 193 GLCRIWDTASGQCLKTLIDDDNPP------VSFVKFSPNGKYILAATLDNTLKLWDYS-K 245 C +WD +GQ + ++ + P +S S N ++ + D T++LWD Sbjct: 180 QTCVLWDVTTGQRI-SIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRIT 238 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 + ++TY GH+ + I + G+ +GS+D +++++T +Q Sbjct: 239 SRAVRTYHGHEGD---INSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQ 285 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 97/228 (42%), Gaps = 27/228 (11%) Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 C +TL+GHS V+ ++ P+ N IVS S D + +W+ T + + H V F Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFA 117 Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV-----------KFSPNGK-Y 228 +G + D C I++ +S D N PVS V ++ P+ + Sbjct: 118 PNGQSVACGGLDSACSIFNLSS-----QADRDGNMPVSRVLTGHKGYASSCQYVPDQETR 172 Query: 229 ILAATLDNTLKLWDYSKGKCLKTY-----TGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 ++ + D T LWD + G+ + + +GH + + N +SGS D V Sbjct: 173 LITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSIN--SLNANMFISGSCDTTV 230 Query: 284 YIWNLQ-TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +W+L+ T V+ GH + S P + + +D T +L+ Sbjct: 231 RLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGS--DDGTCRLF 276 >6EMK-B nrPDB Length = 303 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 114/227 (50%), Gaps = 13/227 (5%) Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 + GH+ ++ V++ D+ +V++S+D T+K+WDV S + K H+ V +P Sbjct: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 ++S D ++RIWD+ +C L P + ++ DGS++ +++ G C +W+ Sbjct: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 Query: 201 -----ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTG 254 AS T + ++ + S + K++ + D+T ++W K T G Sbjct: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG 248 Query: 255 HKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300 H+ + C F+ S ++V+ S D+ V +W+L T+EIV++ GH Sbjct: 249 HQRWVWDCAFSADSA----YLVTASSDHYVRLWDLSTREIVRQYGGH 291 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 + P PV + GH V+SV F + W+ +SS D IK+W + Sbjct: 63 TNPNPVA-------SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK- 114 Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CCNFNPQSNLI 144 H +++V + L+S D ++IWD+ +C L + + +++ Sbjct: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Query: 145 VSGSFDESVRIW------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + + + +W D K + AHS ++ + + D + + S D R+W Sbjct: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 L+T +D V FS + Y++ A+ D+ ++LWD S + ++ Y GH Sbjct: 235 SIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKG 294 Query: 259 KYCIFAN 265 C+ N Sbjct: 295 AVCVALN 301 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 15/243 (6%) Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 S +LVSA D T++ W+ +G C +T++ + V L+ + ++VR++D+ Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDI 60 Query: 159 KTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 +T + + H V++V F +D +V+SS DG ++WD S + N P Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V+ V PN +++ D +++WD + +C T + + S G + + Sbjct: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS--DGSMLAA 176 Query: 277 GSEDNLVYIWNLQTK------EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 + Y+W + + V K + H+ + T + ++ A D T ++W Sbjct: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI--TRILLSSDVKHLATCSADHTARVW 234 Query: 331 KSD 333 D Sbjct: 235 SID 237 >3JAP-g nrPDB Length = 326 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 68/267 (25%), Positives = 123/267 (46%), Gaps = 25/267 (9%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH+ V V S +G + S+S DK +++W G E GH + VA ++S+ + Sbjct: 64 GHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKI 123 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-----------IVSGSFDE 151 +SAS DKT+++W+ + G C L GH+++V P+ NL VS D+ Sbjct: 124 ISASRDKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPK-NLEDGEVDDGRITFVSAGMDK 181 Query: 152 SVRIWDVK--TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 VR W + + + H++ ++ V + DGSL S+ DG +W+ Sbjct: 182 IVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNF 241 Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT----YTGH--KNEKYCIF 263 D V + FSP+ ++ AAT +K++D + + G+ + + + Sbjct: 242 --DAKDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVS 298 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQT 290 +S G + + +G DN++ +W + T Sbjct: 299 LAWSADG-QTLFAGYTDNVIRVWQVMT 324 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/282 (25%), Positives = 135/282 (47%), Gaps = 29/282 (10%) Query: 37 LKFTLAGHTKAVSSVKFS---PNGEWLASSSADKLIKIWGAYDGKFE-----KTISGHKL 88 L+ TL GH V+S+ S PN L S S DK + W + + + ++ GH Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPN--LLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 + DV S+D N VSAS DKTL++W++++G GH+ V + S+ I+S S Sbjct: 68 IVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISAS 127 Query: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN----RDGSL------IVSSSYDGLCRIW 198 D+++R+W+ G C L H+D V+ V DG + VS+ D + R W Sbjct: 128 RDKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSW 186 Query: 199 --DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 + S + I +N ++ V+ SP+G +A D + +W+ + K Sbjct: 187 SLNEDSYRIEADFIGHNN-YINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA-K 244 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 +E + + + + ++ ++ + + + I++L+ + ++ +L+ Sbjct: 245 DEVFAL----AFSPSRFWLTAATASGIKIYDLENEVLIDELK 282 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/269 (25%), Positives = 123/269 (45%), Gaps = 24/269 (8%) Query: 79 FEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSS-----GKCLKTLKGHSNYV 132 T+ GH ++ ++ S+ NLLVS S DKTL W ++ G +++ KGHS+ V Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIV 69 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 + N VS S+D+++R+W++ TG H+ V +V + + S I+S+S D Sbjct: 70 QDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRD 129 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP---------NGKY-ILAATLDNTLKLWD 242 R+W+T G C L+ + V+ V+ +P +G+ ++A +D ++ W Sbjct: 130 KTIRVWNTV-GDCAYVLLGHTDW-VTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS 187 Query: 243 YSKG--KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300 ++ + + GH N + + G S +D +Y+WNL+ K Sbjct: 188 LNEDSYRIEADFIGHNNYINVVQPS---PDGSLAASAGKDGQIYVWNLKHKSAFMNFDAK 244 Query: 301 TDVVISTACHPTENIIASAALENDKTIKL 329 D V + A P+ + +A K L Sbjct: 245 -DEVFALAFSPSRFWLTAATASGIKIYDL 272 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 16/119 (13%) Query: 224 PNGKYILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSG 277 PN +++ + D TL W ++ G +++Y GH + I + V+ G + VS Sbjct: 31 PN--LLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH----IVQDVVVSADGNYAVSA 84 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS--DC 334 S D + +WNL T + GHT V+S A + I SA+ DKTI++W + DC Sbjct: 85 SWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISAS--RDKTIRVWNTVGDC 141 Score = 30.8 bits (68), Expect = 0.84, Method: Compositional matrix adjust. Identities = 31/146 (21%), Positives = 62/146 (42%), Gaps = 26/146 (17%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------YDGKFEKTI 83 + +Y ++ GH ++ V+ SP+G AS+ D I +W +D K E Sbjct: 190 EDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDE--- 246 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSN----YVFCC 135 + +A+S S ++A+ +KI+D+ + + LK G++ + Sbjct: 247 ------VFALAFSP-SRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSL 299 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTG 161 ++ + +G D +R+W V T Sbjct: 300 AWSADGQTLFAGYTDNVIRVWQVMTA 325 >4J0W-A nrPDB Length = 343 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 102/223 (45%), Gaps = 17/223 (7%) Query: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----------GHS 129 + + GH+L I+ + + D + + SA+ D ++ W V SG+ L + GHS Sbjct: 8 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 67 Query: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 ++V C + + SG + + IW+ ++ + L T H D VS + F R + S+ Sbjct: 68 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 127 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 S+D ++W+ A ++TL + + S + A D T+++W + L Sbjct: 128 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRE-CCVTAGGRDGTVRVWKIPEESQL 186 Query: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 Y GH+ CI + + +VSG++D V +W L K Sbjct: 187 VFY-GHQGSIDCIH----LINEEHMVSGADDGSVALWGLSKKR 224 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH+ V + S +G++LAS KLI IW A + T +GH+ +S +A+ ++ L Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 124 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 S S D+++K+W+V+ ++TL GH + V + + + +G D +VR+W + Sbjct: 125 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 184 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 L H + +H + + VS + DG +W Sbjct: 185 QL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALW 218 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 99/219 (45%), Gaps = 20/219 (9%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 +T GH AVS + F L S+S D+ +K+W + + +T+ GH+ ++ + S Sbjct: 103 YTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSR 162 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 + + D T+++W + L GH + C + + ++ VSG+ D SV +W + Sbjct: 163 ECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGL 220 Query: 159 ---------KTGKCLKTLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCL 206 + L+ P P +S+V + L+ + S+ R+W G + L Sbjct: 221 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 280 Query: 207 KTLIDDDNPPVSFV---KFSPNGKYILAAT-LDNTLKLW 241 L D P V F+ KFS +G +++A ++ L W Sbjct: 281 DLLC--DIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 317 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 62/274 (22%), Positives = 112/274 (40%), Gaps = 22/274 (8%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--------- 83 P A L GH +++ + +P+ + S++ D I W G+ I Sbjct: 2 PEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEG 61 Query: 84 --SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 GH + +A SSD L S K + IW+ S + L T GH + V F + Sbjct: 62 KPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 + + S S D SV++W+V ++TL H D V+A+ + + DG R+W Sbjct: 122 HQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIP 181 Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNE 258 L + + + N +++++ D ++ LW SK + L + G + E Sbjct: 182 EESQL--VFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGE 238 Query: 259 -----KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 + I + ++ + +GS + V +W Sbjct: 239 PGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 49/220 (22%), Positives = 96/220 (43%), Gaps = 19/220 (8%) Query: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL-----------PAH 170 ++ L+GH + C P + I S + D S+ W V++G+ L + P H Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 S V + + DG + S L IW+ S Q L T + VS + F + Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRD-AVSGLAFRRGTHQLY 125 Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 + + D ++K+W+ ++ ++T GH++ + A +++ + +G D V +W + Sbjct: 126 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 181 Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +E GH + E++++ A +D ++ LW Sbjct: 182 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 218 >2HES-X nrPDB Length = 330 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/307 (26%), Positives = 130/307 (42%), Gaps = 34/307 (11%) Query: 15 AQPTPSSSATQSKPTPVKPNYALKFTL------AGHTKAVSSVKFSPNGEWLASSSADKL 68 +Q ++ +T K V Y FTL H KA+ SV + P+ LA+ S D Sbjct: 23 SQGILATGSTDRKIKLVSVKYD-DFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDST 81 Query: 69 IKIWG---AYDGKFEK----TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG-- 119 + IW + D FE I GH+ + VAWS+D L + S DK++ IW+ Sbjct: 82 VSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGE 141 Query: 120 --KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVS 175 +C+ L+ HS V ++P L+ S S+D++VRIW +C+ L H V Sbjct: 142 EYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVW 201 Query: 176 AVHFNRDGSL--IVSSSYDGLCRIW--------DTASGQCLKTLIDDDNPPVSFVKFSPN 225 + F++ + + S S D R+W D C L D V V + N Sbjct: 202 SSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFN 261 Query: 226 GKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 G I + D L +++ G+ K H + + + G + +G +D + Sbjct: 262 G-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGI 320 Query: 283 VYIWNLQ 289 V W+L+ Sbjct: 321 VNFWSLE 327 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 108/255 (42%), Gaps = 24/255 (9%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVKPNYALKF--TLAGHTKAVSSVKFSPNGEWLASSS 64 +P T A S+ + +K + + + GH V V +S +G +LA+ S Sbjct: 67 RPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCS 126 Query: 65 ADKLIKIWGAYDGKFE----KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD--VSS 118 DK + IW + E + H + V W LL S+S D T++IW Sbjct: 127 RDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD 186 Query: 119 GKCLKTLKGHSNYVFCCNFNPQSNL--IVSGSFDESVRIW--------DVKTGKCLKTLP 168 +C+ L GH V+ +F+ + + SGS D +VR+W D + C LP Sbjct: 187 WECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILP 246 Query: 169 -AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ---CLKTLIDDDNPPVSFVKF-S 223 H V V + +G LI S DG+ +++ G+ K + ++ VK+ Sbjct: 247 DVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLE 305 Query: 224 PNGKYILAATLDNTL 238 NGK ILA D+ + Sbjct: 306 LNGKTILATGGDDGI 320 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 100/233 (42%), Gaps = 23/233 (9%) Query: 116 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTL--PAHS 171 ++S +K+LK + ++ +F+ ++ +GS D +++ VK + L AH Sbjct: 1 MASINLIKSLKLYKEKIWSFDFSQ--GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHK 58 Query: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIW------DTASGQCLKTLIDDDNPPVSFVKFSPN 225 + +V + SL+ + S+D IW D L +I+ V V +S + Sbjct: 59 KAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSND 118 Query: 226 GKYILAATLDNTLKLWDYSKG----KCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSED 280 G Y+ + D ++ +W+ + +C+ H + K+ I+ + S S D Sbjct: 119 GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEAL----LASSSYD 174 Query: 281 NLVYIWNLQTK--EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + V IW E V L GH V S+ TE + + +D T+++WK Sbjct: 175 DTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWK 227 >5XYI-g nrPDB Length = 335 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 124/275 (45%), Gaps = 17/275 (6%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG------AYDGKFEKTISGHK 87 ++A + T GH A+ S++ +L S+S DK +W + F + I GH Sbjct: 22 HFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLI-GHN 80 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 +SDV+ S D++ L+++S D TL++WD+S+ K GH V F+P + I+S Sbjct: 81 HFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISV 140 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVS---AVHFNRDGSLIVS-SSYDGLCRIWDTASG 203 D V+IW++ G+ L S S A + L+++ +DG IW Sbjct: 141 GRDNQVKIWNI-LGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKE 199 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263 L + + V F+P+GK+++ D + +W G ++T + Sbjct: 200 AKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSP----VH 255 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 A + WI + + + + +W++ K+ + +Q Sbjct: 256 AVAACPTQAWICAATYEGIA-VWDIGAKQQIDLVQ 289 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/130 (20%), Positives = 59/130 (45%), Gaps = 13/130 (10%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 H +SV F+P+G+W+ + +D+ + +W +G KTIS + + Sbjct: 208 AHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGA--KTISFTAPSPVHAVAACPTQAW 265 Query: 103 VSASDDKTLKIWDVSSGKCLKTLK-----------GHSNYVFCCNFNPQSNLIVSGSFDE 151 + A+ + + +WD+ + + + ++ G + C + +++ SG D Sbjct: 266 ICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDG 325 Query: 152 SVRIWDVKTG 161 S+R W+VK+ Sbjct: 326 SIRAWEVKSA 335 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 43/216 (19%), Positives = 71/216 (32%), Gaps = 55/216 (25%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNL 101 GH K V V FSP + S D +KIW + K E S ++ + +++ Sbjct: 120 GHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSP 179 Query: 102 LVSASD--DKTLKIWDVS-SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD-------- 150 LV A D + IW + K +K K H +F P +++G D Sbjct: 180 LVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLT 239 Query: 151 --------------------------------ESVRIWDVKTGKCL-----------KTL 167 E + +WD+ + + K Sbjct: 240 ENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRN 299 Query: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203 + + + + DGS++ S DG R W+ S Sbjct: 300 AGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKSA 335 Score = 27.3 bits (59), Expect = 9.2, Method: Compositional matrix adjust. Identities = 22/123 (17%), Positives = 52/123 (42%), Gaps = 12/123 (9%) Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK-----CLKTYTGHKNEKYCIFANFSV 268 N + ++ Y+++A+ D + +W ++ + GH + ++ S+ Sbjct: 33 NAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNH----FVSDVSL 88 Query: 269 T-GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 + +++ S D+ + +W+L T+ + GH V+ P I S +N + Sbjct: 89 SRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQ--V 146 Query: 328 KLW 330 K+W Sbjct: 147 KIW 149 >5OQL-J nrPDB Length = 912 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 81/308 (26%), Positives = 131/308 (42%), Gaps = 54/308 (17%) Query: 73 GAYDGKFEKTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV----SSGKCLKTLK 126 G+Y G + GH+ + DV WS + + S S D T ++W V +S C Sbjct: 419 GSYFGHDVALLKGHEDIVMSLDVDWSG--HWIASGSKDNTARLWRVDPANNSYTCYAVFT 476 Query: 127 GHSNYVFCCNF-------------NPQSN---LIVSGSFDESVRIWDV-----KTGKCLK 165 GH V NP + ++SGS D V+ D+ K GK Sbjct: 477 GHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTS 536 Query: 166 TLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 +L AH ++A+ + +G L S+S D +IWD + ++ ++ V V+F+ Sbjct: 537 SLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLE-VQGILRGHKRGVWTVRFA 595 Query: 224 P-------------NGK-YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF-----A 264 P +G+ +L + D T+KLW+ S C++T+ GH + + Sbjct: 596 PLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISR 655 Query: 265 NFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323 + S+T K S D LV +W+ T E L H D + + A H NI+ASA + Sbjct: 656 DDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAG--S 713 Query: 324 DKTIKLWK 331 D + W+ Sbjct: 714 DSKVTFWR 721 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 83/179 (46%), Gaps = 23/179 (12%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS------ 96 H K ++++ SPNG+ AS+S DK +KIW + + + GHK G+ V ++ Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 97 --------SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC---------NFNP 139 S ++++ S DKT+K+W++S C++T +GHS+ V + Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITK 661 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 S D V++WD TG+ TL H D + + + +++ S+ D W Sbjct: 662 TKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/262 (23%), Positives = 104/262 (39%), Gaps = 48/262 (18%) Query: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK----CLKTLPAHSDPV 174 G + LKGH + V + + + I SGS D + R+W V C H + V Sbjct: 423 GHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESV 482 Query: 175 SAVHF----------------NRDGSLIVSSSYDGLCRIWDTASG--------QCLKTLI 210 AV + + ++S S D + D L+ L Sbjct: 483 GAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLA 542 Query: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANF--- 266 D + ++ + SPNGK +A+ D T+K+WD K + GHK + + FA Sbjct: 543 HDKD--INALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTP 600 Query: 267 -------SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV-------ISTACHPT 312 SV+G +++GS D + +WNL ++ +GH+ V IS T Sbjct: 601 VIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSIT 660 Query: 313 ENIIASAALENDKTIKLWKSDC 334 + + A+ D +K+W ++ Sbjct: 661 KTKVQFASAGADTLVKVWDANT 682 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 66/303 (21%), Positives = 115/303 (37%), Gaps = 54/303 (17%) Query: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW--------DVSSGKCLKTLKGH 128 GK I G IS + + + L+ S T++I+ D ++T K H Sbjct: 51 GKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPH 110 Query: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF--------- 179 + V + S L+ +G+ D +++IWD+ G T+ S VSA+HF Sbjct: 111 ATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAES 170 Query: 180 ---------------NRDGSLIVS------SSYDGLCRIWDTASGQCLKTLIDDDNPP-- 216 N D I S + DG RI+D D Sbjct: 171 QSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEA 230 Query: 217 ----VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS-VTGG 271 V + +SP +L+ + D T+ LW + G + G ++ + + + G Sbjct: 231 HESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDG----IWQGTPMLRHELLESVGFLNEG 286 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQ---GHTDVVISTACHPTENIIASAALENDKTIK 328 KW+ S ++ IW+ T + K Q + ++S P ++I A + D T+ Sbjct: 287 KWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCA--QADFTLV 344 Query: 329 LWK 331 L++ Sbjct: 345 LYR 347 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 86/375 (22%), Positives = 142/375 (37%), Gaps = 75/375 (20%) Query: 31 VKPNY-----ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 + P+Y L T H V + LA+ +AD IKIW G T+SG Sbjct: 92 ISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSG 151 Query: 86 --------HKLGISDVAWSSDSN----------------------LLVSASDDKTLKIWD 115 H I+ A S SN L + D ++I+D Sbjct: 152 PSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFD 211 Query: 116 VSSGKCL-------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP 168 + + + H + V C ++P+ + ++SGS D+++ +W + G T Sbjct: 212 LYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPM 271 Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID---DDNPPVSFVKFSPN 225 + + +V F +G + S+ G+ RIWDT + + D + +S V P Sbjct: 272 LRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSL-PE 330 Query: 226 GKYILAATLDNTLKLWDY---------SKGKCLKTY---TGHKNEKYCIFANFSVTGGKW 273 IL A D TL L+ S+G L+ + +G +E + Sbjct: 331 RSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMA 390 Query: 274 IVSGSED-NLVYIWNLQT--------------KEIVQKLQGHTDVVISTACHPTENIIAS 318 I + SED +V + + Q V L+GH D+V+S + + IAS Sbjct: 391 IATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIAS 450 Query: 319 AALENDKTIKLWKSD 333 + D T +LW+ D Sbjct: 451 GS--KDNTARLWRVD 463 >5WBU-D nrPDB Length = 328 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 129/289 (44%), Gaps = 26/289 (8%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGISDVAWSS 97 T+ V++++ +P+ +A++ I+++ IS G I+ V + Sbjct: 39 TVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHE 97 Query: 98 DSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 D + + +D T +IWD+ S +C + + ++ + C +P ++ G ++ I Sbjct: 98 DGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP-INCVCLHPNQAELIVGDQSGAIHI 156 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG------QCL-KT 208 WD+KT + +P +++ H + D S + + + G C +W+ G Q + KT Sbjct: 157 WDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKT 216 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW---DYSKGKCLKTYTGHKNEKY----- 260 I +FSP+ + + D T K+W ++S L +G+ E Sbjct: 217 KIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMW 276 Query: 261 -CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 C F+ S ++IV+ S DNL +W ++T EI ++ GH V+ A Sbjct: 277 GCAFSGDS----QYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLA 321 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 57/255 (22%), Positives = 107/255 (41%), Gaps = 18/255 (7%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGI 90 PN + + G K ++SV F +G W+ + D +IW + + I I Sbjct: 76 NPNPIISYD--GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 133 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 + V + L+ + IWD+ + + + + + +P ++ + + + Sbjct: 134 NCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 193 Query: 151 ESVRIWDVKTGKCLKT--------LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 + +W++ G + +PAH+ F+ D +L+ + S D C+IW T++ Sbjct: 194 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 253 Query: 203 GQCLKTL-IDDDNPPVS------FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 + L I NP S FS + +YI+ A+ DN +LW G+ + Y GH Sbjct: 254 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 313 Query: 256 KNEKYCIFANFSVTG 270 + C+ N SV G Sbjct: 314 QKAVVCLAFNDSVLG 328 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 28/252 (11%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 SD +L +A D T++ W SG C +T++ + V P ++I + + + +R++ Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 70 Query: 157 DVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 D+ + + + + +++V F+ DG + + D RIWD S I N Sbjct: 71 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 130 Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-- 272 P++ V PN ++ + +WD LKT NE+ S+T Sbjct: 131 APINCVCLHPNQAELIVGDQSGAIHIWD------LKT---DHNEQLIPEPEVSITSAHID 181 Query: 273 ----WIVSGSEDNLVYIWNLQ---TKEIVQ-----KLQGHTDVVISTACHPTENIIASAA 320 ++ + + Y+WNL E+ Q K+ HT + P ++A+ + Sbjct: 182 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 241 Query: 321 LENDKTIKLWKS 332 D+T K+W++ Sbjct: 242 A--DQTCKIWRT 251 >5L9T-R nrPDB Length = 493 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 112/249 (44%), Gaps = 18/249 (7%) Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 ++ V WS NL+ + ++IWD ++GK L L+GH+ V +N + + SGS Sbjct: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 289 Query: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 D + D++T + + L H V + ++ D L+ S D +W+ +S ++ Sbjct: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349 Query: 208 TLIDDDNPPVSFVKFSPNGKYILAA---TLDNTLKLWDYSKG---KCLKTYTGHKNEKYC 261 + V + +SP+ +LA+ T D ++ W+ G +C+ T + N + Sbjct: 350 QYT-EHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWS 408 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321 AN V+ G N + +W + V KL GH+ V+ A P I + A Sbjct: 409 KHANELVS-----THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGA- 462 Query: 322 ENDKTIKLW 330 D+T++ W Sbjct: 463 -GDETLRFW 470 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/252 (23%), Positives = 114/252 (45%), Gaps = 14/252 (5%) Query: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106 +V+SV +S G +A + ++IW A GK + GH + +AW+++ L S S Sbjct: 231 SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGS 288 Query: 107 DDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164 D+ + D+ + + + L+GH V ++ L+ SG D + +W+ + + Sbjct: 289 RDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348 Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221 + H V A+ ++ +++S + D R W+T +GQ L+ + D V + Sbjct: 349 QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI--DTGSQVCNLA 406 Query: 222 FSPNGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279 +S + +++ N + +W Y + TGH Y + G+ IV+G+ Sbjct: 407 WSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGH---SYRVLYLAMSPDGEAIVTGAG 463 Query: 280 DNLVYIWNLQTK 291 D + WN+ +K Sbjct: 464 DETLRFWNVFSK 475 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 99/217 (45%), Gaps = 10/217 (4%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLI--KIWGAYDGKFEKTISGHKLGISDVAWSSD 98 L GHT V ++ + N E L+S S D++I + + E+ + GH+ + + WS+D Sbjct: 267 LEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTD 324 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVS--GSFDESVRI 155 LL S +D L +W+ SS ++ H V ++P Q L+ S G+ D +R Sbjct: 325 HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRF 384 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY-DGLCRIWDTASGQCLKTLIDDDN 214 W+ TG+ L+ + S + L+ + Y +W S + L Sbjct: 385 WNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSY 444 Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCLK 250 V ++ SP+G+ I+ D TL+ W+ +SK + K Sbjct: 445 -RVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTK 480 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 93/212 (43%), Gaps = 24/212 (11%) Query: 133 FCCNFNPQSNL-IVSGSFDESVRIWDVKTGKCLKT--LPAHSDPVSAVHFNRDGSLIVSS 189 F N S+L ++S V +W T + + L D V++V ++ G+L+ Sbjct: 188 FYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVG 247 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG--K 247 ++ G +IWD A+G+ L ++++ V + + N + + + + D + D + Sbjct: 248 THKGFVQIWDAAAGKKL-SMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQ 304 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHT 301 + GH+ E V G KW + SG DN + +WN + VQ+ H Sbjct: 305 SERRLQGHRQE---------VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHL 355 Query: 302 DVVISTACHPTEN-IIASAALENDKTIKLWKS 332 V + A P ++ ++AS D+ I+ W + Sbjct: 356 AAVKAIAWSPHQHGLLASGGGTADRCIRFWNT 387 >3ODT-A nrPDB Length = 313 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 133/292 (45%), Gaps = 20/292 (6%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 Y L TL GH + V V + + +AS S D +++W D + + ++ V Sbjct: 8 YQLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVC 66 Query: 95 WSSDSNLLVSASDDKTLK---IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 + S+ LL+ D + ++ S L TL GH V C+ + Q +++SGS+D+ Sbjct: 67 YDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNV--CSLSFQDGVVISGSWDK 124 Query: 152 SVRIWDVKTGKCLKTLPAHSDPV---SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208 + ++W K G + L AH+ V V F+ + L ++S D ++W + + +KT Sbjct: 125 TAKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFL--TASADKTIKLW--QNDKVIKT 178 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 N V + +G +I + + D +KL D G L+TY GH++ YCI + Sbjct: 179 FSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCI----KL 233 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320 IVS ED V IW+ + + Q + + S C +II ++ Sbjct: 234 LPNGDIVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSS 285 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/183 (33%), Positives = 95/183 (51%), Gaps = 15/183 (8%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAV---SSVKFSPNGEWLASSSADKLIKIWGAYDGK 78 S + K V +L + L H +V V FS N ++SADK IK+W + K Sbjct: 119 SGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENK--FLTASADKTIKLW--QNDK 174 Query: 79 FEKTISG-HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 KT SG H + +A D + +S S+D +K+ D+ +G L+T +GH ++V+C Sbjct: 175 VIKTFSGIHNDVVRHLAVVDDGHF-ISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKL 233 Query: 138 NPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195 P +++ G D +VRIW + G K + TLPA S + +V +G +IV SS D L Sbjct: 234 LPNGDIVSCGE-DRTVRIWSKENGSLKQVITLPAIS--IWSVDCMSNGDIIVGSS-DNLV 289 Query: 196 RIW 198 RI+ Sbjct: 290 RIF 292 >5OQL-X nrPDB Length = 630 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 76/299 (25%), Positives = 121/299 (40%), Gaps = 44/299 (14%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 T GH KA VK S +G+++ + ADK + ++ A D K K + H+ ++ +A+ + Sbjct: 241 TYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGT 300 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 N L S S D+T+K+W + ++TL GH + + + Q + G+ D + R W V Sbjct: 301 NQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVP 360 Query: 160 TGKCL---------------KTLPAHSDPVSAVH---FNR----DGSLIVSSSYDGLCRI 197 L LP DP SA H +R D + V+ S +G + Sbjct: 361 EESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLAL 420 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257 W S + P A L+ +KL DYS + Sbjct: 421 W-------------------SIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAP 461 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV-VISTACHPTENI 315 + I A ++ I SGS D + +W L E +KL+ + V S C + NI Sbjct: 462 QPRGITALRTLPYSDLIFSGSWDGCIRVWRLS--EDKRKLEAVGILGVGSETCENSTNI 518 >4AEZ-A nrPDB Length = 401 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 66/250 (26%), Positives = 115/250 (46%), Gaps = 17/250 (6%) Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 ++ V WS D + L + + I+DV S L+T+ GH V C ++N +++ SGS Sbjct: 137 VASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWN--RHVLSSGSR 194 Query: 150 DESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208 ++ DV+ + TL HS V + + DG + S D + +IWD A K Sbjct: 195 SGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWD-ARSSIPKF 253 Query: 209 LIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 + N V V + P +LA T+D + W+ + G + T I++ Sbjct: 254 TKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSP 313 Query: 266 FSVTGGKWIVS--GSEDNLVYIWNLQTKEIVQKLQ--GHTDVVISTACHPTENIIASAAL 321 S K I+S G DN + IW+ + + +++ H V+ +A P I+++AA Sbjct: 314 HS----KEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAA- 368 Query: 322 ENDKTIKLWK 331 +D+ +K W+ Sbjct: 369 -SDENLKFWR 377 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/255 (24%), Positives = 121/255 (47%), Gaps = 11/255 (4%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 V+SVK+S +G +L+ + L+ I+ +T++GH+ + ++W + ++L S S Sbjct: 137 VASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW--NRHVLSSGSR 194 Query: 108 DKTLKIWDVS-SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKT 166 + DV + + TL+GHS+ V + + SG D V+IWD ++ T Sbjct: 195 SGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFT 254 Query: 167 LPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 H+ V AV + S ++++ + D W+ A+G + T+ D V+ + +S Sbjct: 255 KTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTV--DAGSQVTSLIWS 312 Query: 224 PNGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 P+ K I++ DN L +W YS K ++ +++ S G + S++N Sbjct: 313 PHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDEN 372 Query: 282 LVYIWNLQTKEIVQK 296 L + W + + V++ Sbjct: 373 LKF-WRVYDGDHVKR 386 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/178 (27%), Positives = 81/178 (45%), Gaps = 8/178 (4%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-D 98 TL GH+ V + + +G LAS D +++IW A + T + H + VAW Sbjct: 212 TLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQ 271 Query: 99 SNLLVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS--GSFDESVR 154 SNLL + DK + W+ ++G + T+ S V ++P S I+S G D ++ Sbjct: 272 SNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-VTSLIWSPHSKEIMSTHGFPDNNLS 330 Query: 155 IWDVKTGKCLKT--LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 IW + K +PAH V + DG ++ +++ D + W G +K I Sbjct: 331 IWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRPI 388 >1NR0-A nrPDB Length = 611 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 99/219 (45%), Gaps = 11/219 (5%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 101 H+ + K SP+G + AS ++IW + TI + D++W S+S Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 Query: 102 LVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDV 158 + + + ++ ++ +G L G + + +F P I+SGS D +V I++ Sbjct: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 K T H+ V +V +N DGSL S+ DG +++ G DD V+ Sbjct: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 Query: 219 F------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251 + +SP+G I +A+ D T+K+W+ + K KT Sbjct: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKT 276 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 103/222 (46%), Gaps = 21/222 (9%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK----FE----KTIS 84 P + K T HTK V SV+++P+G AS+ D I ++ DG FE K ++ Sbjct: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 Query: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144 H + + WS D + SAS DKT+KIW+V++ K KT+ V + Q +I Sbjct: 238 -HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP-----VGTRIEDQQLGII 291 Query: 145 ------VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 VS S + + + + G + H+ ++A+ + DG + S+ +G W Sbjct: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240 D ++G + D ++ +K + G + + D+ LK+ Sbjct: 352 DISTGISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKV 392 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 70/289 (24%), Positives = 120/289 (41%), Gaps = 32/289 (11%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97 H+ +V + +SP+G +AS+SADK IKIW K EKT I +LGI W+ Sbjct: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI---IWTK 294 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 + LVS S + + + G + GH+ + + + + S + + WD Sbjct: 295 QA--LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 Query: 158 VKTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNP 215 + TG + P H+ ++ + G L S D L + SG K + + + Sbjct: 353 ISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSS 412 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 + S +G +AA + + YS GK + + N +N +++ Sbjct: 413 QPLGLAVSADGDIAVAACYKH---IAIYSHGKLTEVPISY-NSSCVALSN----DKQFVA 464 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324 G +D+ V+++ KL G + + T HP E I S A N+ Sbjct: 465 VGGQDSKVHVY---------KLSGASVSEVKTIVHPAE--ITSVAFSNN 502 Score = 34.3 bits (77), Expect = 0.081, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 63/164 (38%), Gaps = 7/164 (4%) Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKY 228 HS + + G S G RIWDT + LKT I + PV + + K Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 Query: 229 ILAAT--LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 I A + ++ + G TG + +F + I+SGS+DN V I+ Sbjct: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSV--DFKPSRPFRIISGSDDNTVAIF 175 Query: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 + HT V S +P ++ AS D TI L+ Sbjct: 176 EGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG--GDGTIVLY 217 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 36/161 (22%), Positives = 72/161 (44%), Gaps = 14/161 (8%) Query: 49 SSVKFSPNGEWLASSSADKLIKIW---GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105 S V S + +++A D + ++ GA + + + H I+ VA+S++ LV+ Sbjct: 452 SCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV--HPAEITSVAFSNNGAFLVAT 509 Query: 106 SDDKTLKIWDVSSGKCLKTLKG---HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 + + + V++ L H+ V C +++P + + +GS D SV +W++ Sbjct: 510 DQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPS 569 Query: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 +K A S S + N + IVS+ D + W+ Sbjct: 570 DHPIIIKGAHAMSSVNSVIWLNE--TTIVSAGQDSNIKFWN 608 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 44/94 (46%), Gaps = 6/94 (6%) Query: 28 PTPVKPNYALKFTLA--GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-- 83 P V N+ L T + HT V+ V +SP+ LA+ S D + +W I Sbjct: 517 PYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIK 576 Query: 84 SGHKL-GISDVAWSSDSNLLVSASDDKTLKIWDV 116 H + ++ V W +++ +VSA D +K W+V Sbjct: 577 GAHAMSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 55/295 (18%), Positives = 111/295 (37%), Gaps = 56/295 (18%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNL 101 GH KA++++ S +G+ L S+ A+ I W G + H I+ + +S +L Sbjct: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDL 381 Query: 102 LVSASDDKTLKI------------------------------WDVSSGKCLKTLKGHSNY 131 + DD LK+ D++ C K + +S+ Sbjct: 382 FTVSWDDH-LKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHG 440 Query: 132 VF----------CCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHF 179 C + + G D V ++ + +KT+ H +++V F Sbjct: 441 KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTI-VHPAEITSVAF 499 Query: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDNT 237 + +G+ +V++ + A+ L V+ V +SP+ + +LDN+ Sbjct: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 Query: 238 LKLWDYSKGK----CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 + +W+ +K +K + I+ N + IVS +D+ + WN+ Sbjct: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT-----IVSAGQDSNIKFWNV 609 >2AQ5-A nrPDB Length = 402 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/188 (28%), Positives = 93/188 (49%), Gaps = 26/188 (13%) Query: 77 GKFEKTIS---GHKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSSG-------KCLKTL 125 G+ +K + GH + D+AW + N++ S S+D T+ +W++ G + + TL Sbjct: 68 GRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITL 127 Query: 126 KGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFNRD 182 +GH+ V ++P + N+++S D + +WDV TG + TL H D + +V ++RD Sbjct: 128 EGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRD 187 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-----PVSFVKFSPNGKYI---LAATL 234 G+LI +S D R+ + G + + D P PV V F GK + + Sbjct: 188 GALICTSCRDKRVRVIEPRKGT---VVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMS 243 Query: 235 DNTLKLWD 242 + + LWD Sbjct: 244 ERQVALWD 251 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/177 (27%), Positives = 82/177 (46%), Gaps = 18/177 (10%) Query: 41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEK-------TISGHKLGISD 92 + GHT V + + P N +AS S D + +W DG T+ GH + Sbjct: 77 VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGI 136 Query: 93 VAW-SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSNLIVSGSF 149 VAW + N+L+SA D + +WDV +G + TL H + ++ +++ LI + Sbjct: 137 VAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCR 196 Query: 150 DESVRIWDVKTGKCL--KTLPAH-SDPVSAVHFNRDGSLIV---SSSYDGLCRIWDT 200 D+ VR+ + + G + K P + PV AV F +G ++ S + +WDT Sbjct: 197 DKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDT 252 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 26/65 (40%), Positives = 34/65 (52%), Gaps = 10/65 (15%) Query: 274 IVSGSEDNLVYIWN-------LQTKEIVQKLQGHTDVVISTACHPT-ENIIASAALENDK 325 I SGSED V +W L +E V L+GHT V A HPT +N++ SA +N Sbjct: 97 IASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDN-- 154 Query: 326 TIKLW 330 I +W Sbjct: 155 VILVW 159 Score = 30.8 bits (68), Expect = 0.76, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 56/130 (43%), Gaps = 13/130 (10%) Query: 135 CNFNPQ-SNLIVSGSFDESVRIWDV-KTGKCLKTLP---AHSDPVSAVHF-NRDGSLIVS 188 C NP+ LI S + + + KTG+ K +P H+ PV + + + ++I S Sbjct: 40 CAVNPKFMALICEASGGGAFLVLPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIAS 99 Query: 189 SSYDGLCRIWDTASGQCLKTL------IDDDNPPVSFVKFSPNGK-YILAATLDNTLKLW 241 S D +W+ G + L ++ V V + P + +L+A DN + +W Sbjct: 100 GSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVW 159 Query: 242 DYSKGKCLKT 251 D G + T Sbjct: 160 DVGTGAAVLT 169 >5WYJ-BE nrPDB Length = 939 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 111/235 (47%), Gaps = 8/235 (3%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 V SV S G + S++ I I+ G K HK ++ ++ + +VS Sbjct: 463 VKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGL 522 Query: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 D + +D + L LK + + ++ S+L D S+ + D T + ++ L Sbjct: 523 DGIVGFYDFNKSTLLGKLKLDAP-ITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQL 581 Query: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227 HS+ ++A F+ +G IVS+S D R WD +G C+ +I D+ + VKFSPNG Sbjct: 582 WGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDN--VATNVKFSPNGD 639 Query: 228 YILAAT--LDNTLKLW-DYSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGS 278 +LA T N + +W + ++ K + T T ++E + SV G ++SG+ Sbjct: 640 -LLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTSVRGNDSMLSGA 693 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/161 (27%), Positives = 81/161 (50%), Gaps = 13/161 (8%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG----ISDVAWSSDS 99 H +AV+ + + S D ++ G YD F K+ KL I+ + + S Sbjct: 501 HKRAVTGISLDGMNRKMVSCGLDGIV---GFYD--FNKSTLLGKLKLDAPITAMVYHRSS 555 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 +L A DD ++ + D + + ++ L GHSN + +F+P+ IVS S D ++R WD+ Sbjct: 556 DLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLP 615 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY--DGLCRIW 198 TG C+ + + + V F+ +G L+ ++ +G+C IW Sbjct: 616 TGGCIDGIIV-DNVATNVKFSPNGDLLATTHVTGNGIC-IW 654 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 7/193 (3%) Query: 100 NLLVSASDDKTLKIWDVSSGKCLK-TLKGHSN-YVFCCNFNPQSNLIVSGSFDESVRIWD 157 N++ + D+K + WD+ + + + T + +V + N GS + S+ I++ Sbjct: 429 NIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYN 488 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 +++G K H V+ + + +VS DG+ +D L L D P+ Sbjct: 489 MQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLD--API 546 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 + + + + A D ++ + D + ++ GH N +FS G +WIVS Sbjct: 547 TAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAF--DFSPEG-RWIVSA 603 Query: 278 SEDNLVYIWNLQT 290 S D+ + W+L T Sbjct: 604 SLDSTIRTWDLPT 616 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 34/67 (50%), Gaps = 11/67 (16%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISDVAWSS 97 GH+ +++ FSP G W+ S+S D I+ W G DG ++ ++V +S Sbjct: 583 GHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVA------TNVKFSP 636 Query: 98 DSNLLVS 104 + +LL + Sbjct: 637 NGDLLAT 643 >5K0Y-T nrPDB Length = 329 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/297 (20%), Positives = 132/297 (44%), Gaps = 33/297 (11%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SDVAWSSD 98 L GH ++++ +K++ G+ L + + D ++ +W + +G+ T GH + D W D Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADW--D 63 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS-----FDESV 153 + +++ S D + ++WD +GK L LK +S V C F+ N+I+ + + V Sbjct: 64 TKHVLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFDFGGNIIMFSTDKQMGYQCFV 122 Query: 154 RIWDVK------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 +D++ + +P + +++ + G I++ G + SG+ L Sbjct: 123 SFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLV 182 Query: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267 + + + ++ ++ S + A+ DNT KL+D + + KT+ + E A S Sbjct: 183 N-VKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTF---RTEPPRELAALS 238 Query: 268 VTGGKWIVSGSEDNL-------------VYIWNLQTKEIVQKLQGHTDVVISTACHP 311 +V G ++ + ++L +E +++GH + S A HP Sbjct: 239 PNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHP 295 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/164 (21%), Positives = 67/164 (40%), Gaps = 15/164 (9%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 ++S + P GE + + + + A G+ + H I+D+ S + + V+AS Sbjct: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASK 208 Query: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV-------------- 153 D T K++D ++ + KT + +P +V G E++ Sbjct: 209 DNTAKLFDSTTLEHQKTFRTEPPRELAA-LSPNYEHVVVGGGQEAMDVTTTSTRIGKFEA 267 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 R + + + + H P+++V F+ DG S DG RI Sbjct: 268 RFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 43/205 (20%), Positives = 90/205 (43%), Gaps = 16/205 (7%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK---FEKTIS-----GHKLGIS 91 T GHT AV V + + + + SAD ++W GK KT S G G + Sbjct: 47 TYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGN 106 Query: 92 DVAWSSDSNL----LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 + +S+D + VS D + + + + + + + + + P I++G Sbjct: 107 IIMFSTDKQMGYQCFVSFFDLRDPS--QIDNNEPYMKIPCNDSKITSAVWGPLGECIIAG 164 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 + + K+G+ L + HS ++ + +R+ ++ V++S D +++D+ + + K Sbjct: 165 HESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQK 224 Query: 208 TLIDDDNPPVSFVKFSPNGKYILAA 232 T + PP SPN ++++ Sbjct: 225 TFRTE--PPRELAALSPNYEHVVVG 247 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/95 (23%), Positives = 47/95 (49%), Gaps = 3/95 (3%) Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 L+ ++ +K++ G + D + +W G+ L TY GH +C+ A++ Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303 K +++GS DN +W+ +T + + L+ ++ V Sbjct: 65 ---KHVLTGSADNSCRLWDCETGKQLALLKTNSAV 96 >4U1E-I nrPDB Length = 347 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 60/235 (25%), Positives = 104/235 (44%), Gaps = 29/235 (12%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH + ++ VK++ G+ L S S D +W + +G+ T+ GH + WS D + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGH----TGTIWSIDVD 61 Query: 101 LL----VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE----- 151 V+ S D ++K+WDVS+G+C+ T K V F+P N ++ D Sbjct: 62 CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVP-VKRVEFSPCGNYFLA-ILDNVMKNP 119 Query: 152 -SVRIWDVKTGKCLKTL------PAHS-------DPVSAVHFNRDGSLIVSSSYDGLCRI 197 S+ I++++ L P H D + ++ G I++ DG Sbjct: 120 GSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISK 179 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 +D ++ ID +S ++FSP+ Y + ++ D L D S + LK Y Sbjct: 180 YDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKY 234 >4A11-B nrPDB Length = 408 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 112/249 (44%), Gaps = 39/249 (15%) Query: 86 HKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-- 142 H+ + V W D+ + S+S DKTLK+WD ++ + V+ + +P S Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKH 156 Query: 143 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDT 200 L+ G+ V++ D+K+G C L H + AV ++ R ++ ++S D ++WD Sbjct: 157 CLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 Query: 201 --ASGQCLKTLIDDD--------------NPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244 ASG CL TL + N V+ + F+ +G ++L DN ++LW+ S Sbjct: 217 RRASG-CLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Query: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLVY--------IWNLQTKEIVQ 295 G+ G K C N S G K+ VS G V+ ++ + + E + Sbjct: 276 NGENTLVNYG----KVC---NNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQIT 328 Query: 296 KLQGHTDVV 304 L+GH V Sbjct: 329 MLKGHYKTV 337 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 58/130 (44%), Gaps = 5/130 (3%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----FEKTISGH 86 K + A++ H V+ + F+ +G L + D +++W + +G+ + K + Sbjct: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 K G+ S+ V T+ ++ V SG+ + LKGH V CC F + S Sbjct: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 Query: 147 GSFDESVRIW 156 GS D ++ W Sbjct: 352 GSRDCNILAW 361 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 79/178 (44%), Gaps = 30/178 (16%) Query: 41 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGA------------YDGK----FEKTI 83 L GH + + +V +SP ++ LA++SAD +K+W ++GK E Sbjct: 182 LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESAN 241 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---------CLKTLKGHSNYVFC 134 + H ++ + ++SD L++ D +++W+ S+G+ C + KG + Sbjct: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG-LKFTVS 300 Query: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 C + + + GS ++ ++ V +G+ + L H V F + + S S D Sbjct: 301 CGCSSEFVFVPYGS---TIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 >5OV3-A nrPDB Length = 381 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/286 (24%), Positives = 116/286 (40%), Gaps = 25/286 (8%) Query: 53 FSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112 F+ G LA D I IW K IS H + + WS D + LVSAS D + Sbjct: 33 FNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVS 92 Query: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNP--QSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170 WDV SG C + + S + ++P Q+ ++V V + + + + Sbjct: 93 QWDVLSGDCDQRFRFPSP-ILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDD 151 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI----DDDNPPVSFVKFSPNG 226 SD F+R G I + + G + T S + + + + ++F+ G Sbjct: 152 SDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKG 211 Query: 227 KYILAATLDNTLKLWDYSK------------GKCLKTYTGHKNEKYCIFANFSVTGGKWI 274 L T D ++++D + + L+ K C F+ G++I Sbjct: 212 SCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSG----DGEYI 267 Query: 275 VSGS-EDNLVYIWNLQTKEIVQKLQG-HTDVVISTACHPTENIIAS 318 V+GS + +YIW +V+ L G ++++ A HP IIAS Sbjct: 268 VAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIAS 313 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 27/71 (38%), Positives = 37/71 (52%) Query: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194 C FN L+ G D + IWD T K + AH PV ++ ++RDG +VS+S D + Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNI 90 Query: 195 CRIWDTASGQC 205 WD SG C Sbjct: 91 VSQWDVLSGDC 101 >3ACP-A nrPDB Length = 417 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 55/246 (22%), Positives = 106/246 (43%), Gaps = 31/246 (12%) Query: 24 TQSKPTPVKPNYALKFTL-AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT 82 T+ + N+ L+ + H ++ +KF P+GE L SSS D +KIW DG +T Sbjct: 114 TEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRT 173 Query: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--------YVFC 134 + GH+ ++D+A ++SAS D T+++W+ +G + T N +F Sbjct: 174 LIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFV 233 Query: 135 ----------------CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 178 F +++G + + +V + + LP+ S Sbjct: 234 GTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKF-TCSCNS 292 Query: 179 FNRDG---SLIVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATL 234 DG + I + +G+ WD S +C + + ++ P++ V F+ G +++ Sbjct: 293 LTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAA-GALFVSSGF 351 Query: 235 DNTLKL 240 D ++KL Sbjct: 352 DTSIKL 357 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 46/208 (22%), Positives = 91/208 (43%), Gaps = 30/208 (14%) Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170 +K+ D + + + H + + F P ++S S D ++IW VK G +TL H Sbjct: 118 IKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGH 177 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------VSFV---- 220 V+ + G ++S+S DG R+W+ +G + T +NP FV Sbjct: 178 RATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDR 237 Query: 221 -------------KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANF 266 +F GKY++A + + + + +SK + ++ ++ C + Sbjct: 238 QLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQL----PSKFTCSCNSL 293 Query: 267 SVTG--GKWIVSGSEDNLVYIWNLQTKE 292 +V G +I +G E+ ++ W+L++ E Sbjct: 294 TVDGNNANYIYAGYENGMLAQWDLRSPE 321 Score = 31.6 bits (70), Expect = 0.52, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 67/155 (43%), Gaps = 11/155 (7%) Query: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 F + GS + + DG +++T K L D V K ++IL T + + Sbjct: 61 FEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMR-RFILGTT-EGDI 118 Query: 239 KLWDYSKGKCLKTYTGHKNE--KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 K+ D + + H +E K F + G+ ++S S+D + IW+++ + Sbjct: 119 KVLDSNFNLQREIDQAHVSEITKLKFFPS-----GEALISSSQDMQLKIWSVKDGSNPRT 173 Query: 297 LQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 L GH V A + SA+L D TI+LW+ Sbjct: 174 LIGHRATVTDIAIIDRGRNVLSASL--DGTIRLWE 206 >1PI6-A nrPDB Length = 615 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 77/314 (24%), Positives = 130/314 (41%), Gaps = 43/314 (13%) Query: 26 SKPTPVKPNYALKFTLAGH-TKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT 82 SK PV ++FT GH + V++VKFSP ++L S + +WG F+K Sbjct: 51 SKVPPV-----VQFT--GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGW---TFDKE 100 Query: 83 ISGHKLG-----------ISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKG 127 + ++ ISD++W + L + + WD SG L + G Sbjct: 101 SNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSG 158 Query: 128 HSNYVFCCNF---NPQSNLIVSGSFDESVRIWD---VKTGKCLKTLPAHSDPVSAVHFNR 181 HS + C+ P ++ V D SV + K +T V V F+ Sbjct: 159 HSQRINACHLKQSRPMRSMTVGD--DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 Query: 182 D-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP---NGKYILAATLDNT 237 D G +++ D +D SG+ LK I+DD PV F+ + + D T Sbjct: 217 DSGEFVITVGSDRKISCFDGKSGEFLK-YIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 Query: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 297 +++WD + KC++ +T K + TG I+S S D + + L E+++ + Sbjct: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 Query: 298 QGHTDVVISTACHP 311 GH + + +P Sbjct: 336 SGHNKGITALTVNP 349 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 82/166 (49%), Gaps = 19/166 (11%) Query: 48 VSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKL----GISDVAWSSDSNLL 102 V V+FSP+ GE++ + +D+ I + G+F K I + GI ++W DS Sbjct: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKF 267 Query: 103 VSASDDKTLKIWDVSSGKCL------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + D T+++WDV++ KC+ K G+ N + I+S S D ++ + Sbjct: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR---IISLSLDGTLNFY 324 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 ++ + LKT+ H+ ++A+ N ++S SYDG W ++S Sbjct: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 >6ELZ-p nrPDB Length = 460 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/312 (23%), Positives = 129/312 (41%), Gaps = 43/312 (13%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 VSS+ + + S S D +++ W G +K SGH I V + S++ L VSA + Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWD-LSGNVQKQYSGHSGPIRAVKYISNTRL-VSAGN 163 Query: 108 DKTLKIW-----------------------DVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144 D+TL++W ++ GK L L+GH V + + S I Sbjct: 164 DRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDNSR-I 222 Query: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204 +S S+D S+ W K + DP+ ++ + + L T + Sbjct: 223 LSASYDNSIGFWST----IYKEMTV-VDPLEDINNPNNKISTAARKRRKLTMKDGTIRRR 277 Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYI-LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263 +L++ PV V F + + + D+T+K WD +C+ T T Y + Sbjct: 278 APLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRT----TSYSLL 333 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQ----TKEIVQKLQGHTDVVIST-ACHPTENIIAS 318 + ++ + GS + + + + +K Q+L GH + V S C E I+ S Sbjct: 334 SIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCS 393 Query: 319 AALENDKTIKLW 330 + +D T+K+W Sbjct: 394 GS--HDGTVKVW 403 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 27/137 (19%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 + ++V + S I+SGS+D VR WD+ +G K HS P+ AV + + L V Sbjct: 102 NEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTRL-V 159 Query: 188 SSSYDGLCRIWDTAS-----------------------GQCLKTLIDDDNPPVSFVKFSP 224 S+ D R+W T + G+ L +++ PV + S Sbjct: 160 SAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTL-AILEGHKAPVVSIDVSD 218 Query: 225 NGKYILAATLDNTLKLW 241 N + IL+A+ DN++ W Sbjct: 219 NSR-ILSASYDNSIGFW 234 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 S+D+ + S S D T+K WD+ + +C+ T + + + NL+ GS + + Sbjct: 297 STDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTL-NLLACGSSARHITL 355 Query: 156 WDVKTGKCLKT----LPAHSDPVSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLI 210 D + G K L H + VS++ + I+ S S+DG ++WD S + T+ Sbjct: 356 HDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTIT 415 Query: 211 DDD 213 +D Sbjct: 416 RED 418 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 59/148 (39%), Gaps = 30/148 (20%) Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228 ++ D VS++ I+S SYDG+ R WD SG K + P+ VK+ N + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWD-LSGNVQKQY-SGHSGPIRAVKYISNTRL 158 Query: 229 ILAATLDNTLKLW-----------------------DYSKGKCLKTYTGHKNEKYCIFAN 265 + A D TL+LW + GK L GHK + Sbjct: 159 VSAGN-DRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHK----APVVS 213 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEI 293 V+ I+S S DN + W+ KE+ Sbjct: 214 IDVSDNSRILSASYDNSIGFWSTIYKEM 241 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 18/63 (28%), Positives = 36/63 (57%), Gaps = 4/63 (6%) Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 G K I+SGS D +V W+L + + ++ GH+ + + ++++ ND+T++L Sbjct: 114 GSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTRLVSAG---NDRTLRL 169 Query: 330 WKS 332 WK+ Sbjct: 170 WKT 172 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 10/82 (12%) Query: 41 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGH----KLGISD--- 92 L GH VSS+ P E+ L S S D +K+W TI+ + G++D Sbjct: 371 LIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVF 430 Query: 93 -VAWSSDSNLLVSASDDKTLKI 113 V W+ ++SA DK ++I Sbjct: 431 AVKWAEKVG-IISAGQDKKIQI 451 >4XYI-A nrPDB Length = 430 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 70/242 (28%), Positives = 115/242 (47%), Gaps = 45/242 (18%) Query: 125 LKGHSNYVFCCNFN-PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD--PVSAVHFN- 180 L+ H++ F +N Q + +G+ D S+ +WD+K GK L +L D PVS H + Sbjct: 178 LRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIK-GKSL-SLEKSIDVAPVSVYHRHT 235 Query: 181 ----------RDGSLIVSSSYDGLCRIWDT------ASGQCLKTLIDDDNPPVSFVKFSP 224 + +L+ S S D +I DT ++ QC+K PV+ V F+P Sbjct: 236 AVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKA----HEQPVNGVAFNP 291 Query: 225 NGKYILA-ATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 Y+LA A+ D+T+ LWD + + L T GH++E Y + +S +V+ S D Sbjct: 292 FNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNV--QWSPHDEPILVTSSTDRR 349 Query: 283 VYIWNL------QT--------KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328 V +W+L QT E++ GHT+ V + +P N A+L +D ++ Sbjct: 350 VCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPN-NKWVLASLADDNILQ 408 Query: 329 LW 330 +W Sbjct: 409 IW 410 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 70/134 (52%), Gaps = 18/134 (13%) Query: 41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVAWS-S 97 + H + V+ V F+P N LA++SAD + +W + T+ GH+ + +V WS Sbjct: 277 VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPH 336 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLK--------------GHSNYVFCCNFNPQSNL 143 D +LV++S D+ + +WD+S +T++ GH+N V ++NP + Sbjct: 337 DEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKW 396 Query: 144 IVSGSFDESV-RIW 156 +++ D+++ +IW Sbjct: 397 VLASLADDNILQIW 410 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 16/91 (17%) Query: 40 TLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTIS-------------- 84 TL GH V +V++SP+ E L +SS D+ + +W E+T+ Sbjct: 320 TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHG 379 Query: 85 GHKLGISDVAWSSDSN-LLVSASDDKTLKIW 114 GH +SD++W+ ++ +L S +DD L+IW Sbjct: 380 GHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 31/64 (48%), Gaps = 17/64 (26%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 L F GHT VS + ++PN +W LAS + D +++IW S V W Sbjct: 374 LMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSP----------------SKVIW 417 Query: 96 SSDS 99 +SDS Sbjct: 418 ASDS 421 >4YCZ-A nrPDB Length = 876 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 70/266 (26%), Positives = 114/266 (42%), Gaps = 46/266 (17%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNF-NPQ 140 SGH I D L + S D+T+KI+++ + + +TLKGH V+C ++ +P+ Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 141 -SNLIVSGSFDESVRIWDVKTGKCLKT--LPAHSDPVSAVHF--NRDGSLIVSSSYDGLC 195 N++ S +D V IW G + H V+ V + + G L+ +S DG Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 + + ++ V+ V ++P AT S G + + G Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAP-------AT----------SPGSIVSSKPGP 177 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDVVISTACH 310 K+ TG + V+G DN + IW KL+ GHTD V A Sbjct: 178 KS-----------TGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWS 226 Query: 311 PT---ENIIASAALENDKTIKLWKSD 333 PT ++ IASA+ D+T+++W SD Sbjct: 227 PTVLQKSYIASAS--EDRTVRIWTSD 250 >4BH6-A nrPDB Length = 308 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/243 (22%), Positives = 109/243 (44%), Gaps = 11/243 (4%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 ++W + L + ++I+DV KC++TL GH + V C ++N ++++ SGS D Sbjct: 68 LSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHR 125 Query: 153 VRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 + DV+ +T+ +H+ V + +N + + S D + +++ S + T D Sbjct: 126 ILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF-D 184 Query: 212 DDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 + V + +SP+ + +LA T D LK+W+ + +K + C Sbjct: 185 EHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVN--TSIKMSDIDSGSQICNMVWSKN 242 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328 T G + +W+ + + + L+GH+ V+ + S A D+T++ Sbjct: 243 TNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA--GDETLR 300 Query: 329 LWK 331 WK Sbjct: 301 YWK 303 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 37/124 (29%), Positives = 62/124 (50%), Gaps = 8/124 (6%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDG-KFEKTISGHKLGISDVA 94 T H AV ++ +SP+ + ++ +AD+ +KIW K SG + I ++ Sbjct: 181 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ--ICNMV 238 Query: 95 WSSDSNLLVSAS--DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 WS ++N LV++ L +WD +S + LKGHS V + +VSG+ DE+ Sbjct: 239 WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDET 298 Query: 153 VRIW 156 +R W Sbjct: 299 LRYW 302 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 76/166 (45%), Gaps = 10/166 (6%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 T+ HT+ V +K++ LAS D ++ ++ T HK + +AWS Sbjct: 140 TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHK 199 Query: 100 NLLVS---ASDDKTLKIWDVSSGKCLKTLKGHS---NYVFCCNFNPQSNLIVSGSFDE-S 152 +++ + D+ LKIW+V++ + + S N V+ N N L+ S + + + Sbjct: 200 RGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNE---LVTSHGYSKYN 256 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + +WD + + L HS V + + DG+ +VS + D R W Sbjct: 257 LTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 302 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/241 (21%), Positives = 102/241 (42%), Gaps = 13/241 (5%) Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 G LA A+ L++I+ K +T+SGH ++ ++W ++++L S S D + DV Sbjct: 74 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDV 131 Query: 117 SS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 175 +T++ H+ V +N N + SG D V +++ + + T H V Sbjct: 132 RMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVK 191 Query: 176 AVHF--NRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 A+ + ++ G L + D +IW+ + + + D + + +S N ++ + Sbjct: 192 AMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI--DSGSQICNMVWSKNTNELVTS 249 Query: 233 --TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 L LWD + + GH + + G +VSG+ D + W L Sbjct: 250 HGYSKYNLTLWDCNSMDPIAILKGH---SFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 306 Query: 291 K 291 K Sbjct: 307 K 307 >5A31-R nrPDB Length = 386 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/245 (22%), Positives = 110/245 (44%), Gaps = 11/245 (4%) Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 + ++W + L + ++I+DV KC++TL GH + V C ++N ++++ SGS D Sbjct: 135 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRD 192 Query: 151 ESVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 + DV+ +T+ +H+ V + +N + + S D + +++ S + T Sbjct: 193 HRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF 252 Query: 210 IDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 D+ V + +SP+ + +LA T D LK+W+ + +K + C Sbjct: 253 -DEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVN--TSIKMSDIDSGSQICNMVWS 309 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326 T G + +W+ + + + L+GH+ V+ + S A D+T Sbjct: 310 KNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA--GDET 367 Query: 327 IKLWK 331 ++ WK Sbjct: 368 LRYWK 372 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 37/124 (29%), Positives = 62/124 (50%), Gaps = 8/124 (6%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDG-KFEKTISGHKLGISDVA 94 T H AV ++ +SP+ + ++ +AD+ +KIW K SG + I ++ Sbjct: 250 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ--ICNMV 307 Query: 95 WSSDSNLLVSAS--DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 WS ++N LV++ L +WD +S + LKGHS V + +VSG+ DE+ Sbjct: 308 WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDET 367 Query: 153 VRIW 156 +R W Sbjct: 368 LRYW 371 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 76/166 (45%), Gaps = 10/166 (6%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 T+ HT+ V +K++ LAS D ++ ++ T HK + +AWS Sbjct: 209 TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHK 268 Query: 100 NLLVS---ASDDKTLKIWDVSSGKCLKTLKGHS---NYVFCCNFNPQSNLIVSGSFDE-S 152 +++ + D+ LKIW+V++ + + S N V+ N N L+ S + + + Sbjct: 269 RGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNE---LVTSHGYSKYN 325 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + +WD + + L HS V + + DG+ +VS + D R W Sbjct: 326 LTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 371 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 101/238 (42%), Gaps = 13/238 (5%) Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 G LA A+ L++I+ K +T+SGH ++ ++W ++++L S S D + DV Sbjct: 143 GSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDV 200 Query: 117 SS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 175 +T++ H+ V +N N + SG D V +++ + + T H V Sbjct: 201 RMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVK 260 Query: 176 AVHF--NRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 A+ + ++ G L + D +IW+ + + + D + + +S N ++ + Sbjct: 261 AMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI--DSGSQICNMVWSKNTNELVTS 318 Query: 233 --TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 L LWD + + GH + + G +VSG+ D + W L Sbjct: 319 HGYSKYNLTLWDCNSMDPIAILKGH---SFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 >3CFV-B nrPDB Length = 414 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 110/236 (46%), Gaps = 34/236 (14%) Query: 83 ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFC 134 + GH+ ++W+S+ S L+SASDD T+ +WD+++G GHS V Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 135 CNFN-PQSNLIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS- 189 ++ +L S + D+ + IWD + T K + AH+ V+ + FN I+++ Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 294 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK--- 245 S D +WD + + + + V +SP+ + ILA++ D L +WD SK Sbjct: 295 SADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGE 354 Query: 246 -----------GKCLKTYTGHKNEKYCIFANFSVTGGK-WIV-SGSEDNLVYIWNL 288 + L + GH + ++FS + W++ S SEDN++ IW + Sbjct: 355 EQSAEDAEDGPPELLFIHGGHTAK----ISDFSWNPNEPWVICSVSEDNIMQIWQM 406 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 44/157 (28%), Positives = 72/157 (45%), Gaps = 27/157 (17%) Query: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGK 78 + S T SKP+ + + HT V+ + F+P E+ LA+ SADK + +W + K Sbjct: 259 TRSNTTSKPSHL---------VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 309 Query: 79 FE-KTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS--------------GKCL 122 + T HK I V WS + +L S+ D+ L +WD+S + L Sbjct: 310 LKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELL 369 Query: 123 KTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDV 158 GH+ + ++NP +I S S D ++IW + Sbjct: 370 FIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 >5MWJ-A nrPDB Length = 337 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 58/285 (20%), Positives = 109/285 (38%), Gaps = 16/285 (5%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 69 T + QP P + P P +A + H + V +V S N + + Sbjct: 18 TADGQMQPVPF--PPDALIGPGIPRHARQINTLNHGEVVCAVTIS-NPTRHVYTGGKGCV 74 Query: 70 KIWGAYDGKFEKTIS-----GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCL 122 K+W + +S I D L+ + TL IWD+++ + Sbjct: 75 KVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIK 134 Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182 L + + +P S + S D ++ +WD+ ++ H+D S + + D Sbjct: 135 AELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISND 194 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 G+ + + D R WD G+ L+ D + + + P G+++ + +++ Sbjct: 195 GTKLWTGGLDNTVRSWDLREGRQLQQ--HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH 252 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 +K Y H +E + F+ G KW VS +DNL+ W Sbjct: 253 VNKPD---KYQLHLHESCVLSLKFAYCG-KWFVSTGKDNLLNAWR 293 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 46/210 (21%), Positives = 84/210 (40%), Gaps = 4/210 (1%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 P +K L A ++ SP+ + S +D I +W ++ + GH G S Sbjct: 129 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC 188 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 + S+D L + D T++ WD+ G+ L+ ++ +F + P + G + Sbjct: 189 IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSN 247 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 V + V + L H V ++ F G VS+ D L W T G + Sbjct: 248 VEVLHVNKPDKYQ-LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSK 304 Query: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 ++ V S + KYI+ + D +++ Sbjct: 305 ESSSVLSCDISVDDKYIVTGSGDKKATVYE 334 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/207 (23%), Positives = 83/207 (40%), Gaps = 21/207 (10%) Query: 111 LKIWD---------VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK-- 159 +K+WD VS CL NY+ C P ++ G ++ IWD+ Sbjct: 74 VKVWDISHPGNKSPVSQLDCLN----RDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAP 129 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 T + L + + A+ + D + S DG +WD + Q L S Sbjct: 130 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN-QTLVRQFQGHTDGASC 188 Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279 + S +G + LDNT++ WD +G+ L+ + IF+ G+W+ G E Sbjct: 189 IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ----IFSLGYCPTGEWLAVGME 244 Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVIS 306 + V + ++ + Q L H V+S Sbjct: 245 SSNVEVLHVNKPDKYQ-LHLHESCVLS 270 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/194 (24%), Positives = 78/194 (40%), Gaps = 28/194 (14%) Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH-FNRDG------------S 184 NP ++ G V++WD+ + P + PVS + NRD + Sbjct: 61 NPTRHVYTGGK--GCVKVWDI-------SHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCT 111 Query: 185 LIVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243 LIV L IWD A+ +K + P + SP+ K + D + +WD Sbjct: 112 LIVGGEASTL-SIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDL 170 Query: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303 ++ + GH + CI + S G K + +G DN V W+L+ +Q+ T Sbjct: 171 HNQTLVRQFQGHTDGASCI--DISNDGTK-LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQ 226 Query: 304 VISTACHPTENIIA 317 + S PT +A Sbjct: 227 IFSLGYCPTGEWLA 240 >3C9C-A nrPDB Length = 432 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 109/232 (46%), Gaps = 26/232 (11%) Query: 83 ISGHKLGISDVAWSSDSN-LLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFC 134 + GH+ ++W+ + N L+SASDD T+ +WD+++ GH+ V Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 135 CNFN-PQSNLIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS- 189 ++ +L S + D+ + IWD + T K T+ AH+ V+ + FN I+++ Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 298 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK-GK 247 S D +WD + + + + V++SP+ + ILA++ D L +WD SK G+ Sbjct: 299 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGE 358 Query: 248 CLKTYTGHKNEKYCIF---------ANFSVTGGK-WIV-SGSEDNLVYIWNL 288 T +F ++FS + WI+ S SEDN++ +W + Sbjct: 359 EQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 38/137 (27%), Positives = 65/137 (47%), Gaps = 18/137 (13%) Query: 40 TLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWS- 96 T+ HT V+ + F+P E+ LA+ SADK + +W + K + + HK I V WS Sbjct: 274 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 333 Query: 97 SDSNLLVSASDDKTLKIWDVSS--------------GKCLKTLKGHSNYVFCCNFNPQSN 142 + +L S+ D+ L +WD+S + L GH+ + ++NP Sbjct: 334 HNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEP 393 Query: 143 LIV-SGSFDESVRIWDV 158 I+ S S D +++W + Sbjct: 394 WIICSVSEDNIMQVWQM 410 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIW 72 L F GHT +S ++PN W + S S D ++++W Sbjct: 372 LLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 >5WJC-A nrPDB Length = 430 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 113/248 (45%), Gaps = 37/248 (14%) Query: 116 VSSGKCLK--TLKGHS--NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-------- 163 +++G+ L LKGH+ + C N N NL +G+ D+ + +WDV+T Sbjct: 167 LTTGEALPQAVLKGHTAEGFGLCWNPNLPGNL-ATGAEDQVICLWDVQTQSFTSSETKVI 225 Query: 164 --LKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVS 218 + H+D V+ V F+ + +L+ S S D +I DT + +I + ++ Sbjct: 226 SPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAIN 285 Query: 219 FVKFSPNGKYILA-ATLDNTLKLWDYSKG-KCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V +P Y+LA A+ D T+ LWD + L T GH++E Y + +S + S Sbjct: 286 AVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGL--EWSPHDEPILAS 343 Query: 277 GSEDNLVYIWNLQ--------------TKEIVQKLQGHTDVVISTACHPTENIIASAALE 322 S D V IW+L+ + E++ GHT+ + + P E + +L Sbjct: 344 SSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVV-GSLA 402 Query: 323 NDKTIKLW 330 +D +++W Sbjct: 403 DDNILQIW 410 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 42/123 (34%), Positives = 66/123 (53%), Gaps = 7/123 (5%) Query: 44 HTKAVSSVKFSPNGE-WLASSSADKLIKIWGAY---DGKFEKTISGHKLGISDVAWSS-D 98 HT V+ V+F P E LAS S D ++I + + K I H I+ VA + + Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFN 293 Query: 99 SNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIW 156 LL +AS DKT+ +WD+ + + L TL+GH + V+ ++P ++ S S D V IW Sbjct: 294 DYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIW 353 Query: 157 DVK 159 D++ Sbjct: 354 DLE 356 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/99 (34%), Positives = 46/99 (46%), Gaps = 16/99 (16%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIW------------GAYDGKFEK 81 Y TL GH V +++SP+ E LASSS D+ + IW A DG E Sbjct: 315 YQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPEL 374 Query: 82 TI--SGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDVS 117 GH IS+ +W + +V S +DD L+IW S Sbjct: 375 LFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWSPS 413 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 16/112 (14%) Query: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 YI T + L + LK GH E + + N ++ G + +G+ED ++ +W+ Sbjct: 157 YIFDTTCHDALTTGEALPQAVLK---GHTAEGFGLCWNPNLPGN--LATGAEDQVICLWD 211 Query: 288 LQTKEI----------VQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 +QT+ + K HTD+V HP + A++ +D T+++ Sbjct: 212 VQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALL-ASVSDDCTLQI 262 >5WLC-LJ nrPDB Length = 513 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 103/214 (48%), Gaps = 15/214 (7%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK---FEKTISGHKLGISDVAWS 96 T + V S F +G+ L + A L+ ++ +Y+ + S H ++ + Sbjct: 76 TFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFH-T 134 Query: 97 SDSNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVR 154 D+ +L +ASDD+ ++WD+S+ + L G ++YV +F P + +L+ +GS+D +R Sbjct: 135 QDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIR 194 Query: 155 IWDVKTGKCLKTLPA-HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 ++D ++ H PV V + IVS + ++WD S + L + Sbjct: 195 LYDTRSSGSTPIYSLNHDQPVENV-IAVSPTQIVSCGGNNF-KVWDLTSNKKLYER-GNF 251 Query: 214 NPPVSFVKF-----SPNGKYILAATLDNTLKLWD 242 N V+ + + SP ++A++LD +K++D Sbjct: 252 NKAVTCLDYVENFDSPMQSALIASSLDGHVKVFD 285 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 50/197 (25%), Positives = 85/197 (43%), Gaps = 12/197 (6%) Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182 + +K H N V +FNPQ + + V+I+ +T + +KT D V + F D Sbjct: 34 QLVKEH-NSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSD 92 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLW 241 G L+ + GL ++D+ + + + I+ P KF ILA A+ D +LW Sbjct: 93 GKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLW 152 Query: 242 DYSKG-KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300 D S + TG + Y +F + +GS D L+ +++ ++ G Sbjct: 153 DISNAYEPQLELTGATD--YVRTLSFIPAAPHLVATGSYDGLIRLYDTRSS-------GS 203 Query: 301 TDVVISTACHPTENIIA 317 T + P EN+IA Sbjct: 204 TPIYSLNHDQPVENVIA 220 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/135 (19%), Positives = 63/135 (46%), Gaps = 3/135 (2%) Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPA 169 ++I+ + + +KT + V+ +F L+ +G V ++D + L ++ A Sbjct: 63 VQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINA 122 Query: 170 HSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228 + P F+ +D ++ ++S D + R+WD ++ + + V + F P + Sbjct: 123 STHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPH 182 Query: 229 ILA-ATLDNTLKLWD 242 ++A + D ++L+D Sbjct: 183 LVATGSYDGLIRLYD 197 >4OWR-A nrPDB Length = 339 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 67/118 (56%), Gaps = 9/118 (7%) Query: 132 VFCCNFNPQS---NLIVSGSFDESVRIWDVK-TGKCL-KTLPAHSDPVSAVHFNRDGSLI 186 + C +F+P + N +++GS+ VR W+V+ +G+ + K H+ PV V ++ DGS + Sbjct: 13 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKV 72 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF--SPNGKYILAATLDNTLKLWD 242 ++S D ++WD +S Q ++ I + PV + + +PN ++ + D TLK WD Sbjct: 73 FTASCDKTAKMWDLSSNQAIQ--IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 34/128 (26%), Positives = 65/128 (50%), Gaps = 8/128 (6%) Query: 47 AVSSVKFSPN---GEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 101 ++ + FSP G +L + S ++ W D K H + DV WS D + Sbjct: 12 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK 71 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF--NPQSNLIVSGSFDESVRIWDVK 159 + +AS DKT K+WD+SS + ++ + H V ++ P + +++GS+D++++ WD + Sbjct: 72 VFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 130 Query: 160 TGKCLKTL 167 + + L Sbjct: 131 SSNPMMVL 138 Score = 35.8 bits (81), Expect = 0.025, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 41/85 (48%), Gaps = 3/85 (3%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-- 101 HT V V +S +G + ++S DK K+W + + I+ H + + W N Sbjct: 56 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSC 114 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLK 126 +++ S DKTLK WD S + L+ Sbjct: 115 VMTGSWDKTLKFWDTRSSNPMMVLQ 139 Score = 35.4 bits (80), Expect = 0.036, Method: Compositional matrix adjust. Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 9/120 (7%) Query: 183 GSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 G+ +++ S+ R W+ SGQ + PV V +S +G + A+ D T K+W Sbjct: 25 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 84 Query: 242 DYSKGKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 D S + ++ K + N+S +++GS D + W+ ++ + LQ Sbjct: 85 DLSSNQAIQIAQHDAPVKTIHWIKAPNYSC-----VMTGSWDKTLKFWDTRSSNPMMVLQ 139 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 26/57 (45%), Gaps = 1/57 (1%) Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV-SSSYD 192 F+P + + D WD LKT P+SA FN +G++ +SSYD Sbjct: 252 FHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYD 308 >5Y1U-A nrPDB Length = 456 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 114/236 (48%), Gaps = 34/236 (14%) Query: 83 ISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSS----GKCLKT---LKGHSNYVFC 134 + GH+ ++W+ + S L+SASDD T+ +WD+S+ GK + GH+ V Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 135 CNFN-PQSNLIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS- 189 +++ +L S + D+ + IWD + T K ++ AH+ V+ + FN I+++ Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 323 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK--- 245 S D +WD + + + + V++SP+ + ILA++ D L +WD SK Sbjct: 324 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE 383 Query: 246 -----------GKCLKTYTGHKNEKYCIFANFSVTGGK-WIV-SGSEDNLVYIWNL 288 + L + GH + ++FS + W++ S SEDN++ +W + Sbjct: 384 EQSPEDAEDGPPELLFIHGGHTAK----ISDFSWNPNEPWVICSVSEDNIMQVWQM 435 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/145 (26%), Positives = 69/145 (47%), Gaps = 22/145 (15%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFE-KTISGHKLG 89 KP++++ HT V+ + F+P E+ LA+ SADK + +W + K + + HK Sbjct: 295 KPSHSVD----AHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE 350 Query: 90 ISDVAWS-SDSNLLVSASDDKTLKIWDVSS--------------GKCLKTLKGHSNYVFC 134 I V WS + +L S+ D+ L +WD+S + L GH+ + Sbjct: 351 IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISD 410 Query: 135 CNFNPQSN-LIVSGSFDESVRIWDV 158 ++NP +I S S D +++W + Sbjct: 411 FSWNPNEPWVICSVSEDNIMQVWQM 435 >5OQL-d nrPDB Length = 446 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 67/301 (22%), Positives = 123/301 (40%), Gaps = 56/301 (18%) Query: 43 GHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEK-TISGHKLGISDVAWSSDSN 100 GH + V S+ N +AS S D ++K+W E ++ H + + +++D Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 101 LLVSASDDKTLKIWDV----SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 LL A+D +K+WD S+ + T + Y +F+ +N + S +RIW Sbjct: 124 LLSCATDG--IKLWDPYASPSNTTPIATWQEGGPYT-SLSFHRSANTFAASSGQGCIRIW 180 Query: 157 DVKTGKCLKTL--PAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQ-CLKTLI-- 210 D++ + + P+ D ++ V FN+ + S+I S + D ++D + +KT++ Sbjct: 181 DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 211 -------------------DDDN--------------------PPVSFVKFSPNGKYILA 231 +D N V V+FSP G+ +++ Sbjct: 241 ACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVS 300 Query: 232 ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291 + D T++LW G Y H +F K+I++GS+D V +W Sbjct: 301 GSYDRTIRLWRRDAGHSRDVY--HTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANAS 358 Query: 292 E 292 E Sbjct: 359 E 359 >6BX3-B nrPDB Length = 412 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 128/290 (44%), Gaps = 40/290 (13%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG-----ISDVAWSSDSNLLVSA 105 ++FSP G++LA A+ + I+ D + G+ LG I+ +AWS D LL+++ Sbjct: 31 LQFSPCGDYLALGCANGALVIYDM-DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 89 Query: 106 SDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES------------ 152 S D ++K+WD+S K LK ++ S C + + L V+ F+ES Sbjct: 90 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 149 Query: 153 VRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSS--YDGLCRIWDTASGQCLKTL 209 + K L + P H V VH +IV +S + + +C+ +L Sbjct: 150 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 209 Query: 210 -IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS---KGKCLKTYTGHKNEKY----- 260 I N + + S NG+ + D T++ ++ S + ++ HK + Sbjct: 210 KITSSN--IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQ 267 Query: 261 --CIFANFSVTGGKWIVS---GSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305 CI FS +++V+ GS + +YIW + +V+ L+G + +I Sbjct: 268 WNCIL--FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELI 315 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 58/286 (20%), Positives = 120/286 (41%), Gaps = 49/286 (17%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-------AYDGKFEKTISG-------H 86 L H + ++S+ +SP+G L +SS D IK+W + +F+ I G Sbjct: 67 LGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKR 126 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 +L ++ + SD+ ++ S+D + S K L + H + C N+I+ Sbjct: 127 RLCVATIFEESDA-YVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIV 185 Query: 147 GS---FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203 G+ + + + + +C+ +L S + + +++G + + D R ++ + Sbjct: 186 GTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEIS-- 243 Query: 204 QCLKTLIDDDNPPVSF-----------------VKFSPN-GKYILAATLDNT---LKLWD 242 IDD+N V + FS N +Y++A+T ++ L +W+ Sbjct: 244 ------IDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 297 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 + G ++ G + E I N+ + +G E VY+W++ Sbjct: 298 TTSGTLVRVLEGAEEE--LIDINWDFYSMSIVSNGFESGNVYVWSV 341 >3JB9-S nrPDB Length = 488 Score = 53.9 bits (128), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 76/148 (51%), Gaps = 6/148 (4%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107 V+ ++ P+GE+L ++S +K I+ + T++ H I+ +A D NL V+ + Sbjct: 298 VNFLQAHPSGEYLLAASNEKCY-IFSLKSQVYNITVAQH---ITSLAVHPDGNLFVAGLE 353 Query: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKCLKT 166 + L+ ++ SSG L HS+ V F L+V+ + D + IWD++ + ++ Sbjct: 354 NGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQK 413 Query: 167 LPAHSDPVSAVHFNRDGSLIVSSSYDGL 194 +P + V+AV + L+VSS + L Sbjct: 414 IPLQTK-VAAVSLDITSQLLVSSDGETL 440 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 74/165 (44%), Gaps = 31/165 (18%) Query: 102 LVSASDDK----TLK--IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 L++AS++K +LK +++++ + + +L H P NL V+G + +R Sbjct: 310 LLAASNEKCYIFSLKSQVYNITVAQHITSLAVH----------PDGNLFVAGLENGELRF 359 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 ++ +G L HS PV + F +G L+V+++ D IWD + ++ + Sbjct: 360 FETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKI----- 414 Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259 P + A +LD T +L S G+ L + K+ K Sbjct: 415 ---------PLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKSSK 450 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 2/80 (2%) Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 P+G +A + L+ ++ S G L + H + + F G +V+ ++D+ + Sbjct: 343 PDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTL--QFGENGYWLVVTTNDDSDI 400 Query: 284 YIWNLQTKEIVQKLQGHTDV 303 +IW+L+ E+VQK+ T V Sbjct: 401 FIWDLRKSELVQKIPLQTKV 420 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 61/114 (53%), Gaps = 6/114 (5%) Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 +P +++ S +E I+ +K+ T+ H ++++ + DG+L V+ +G R Sbjct: 304 HPSGEYLLAAS-NEKCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFVAGLENGELRF 359 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT-LKLWDYSKGKCLK 250 ++T+SG L T + PV ++F NG +++ T D++ + +WD K + ++ Sbjct: 360 FETSSGNEL-TKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQ 412 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 37/71 (52%), Gaps = 3/71 (4%) Query: 44 HTKAVSSVKFSPNGEWL-ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 H+ V +++F NG WL +++ D I IW + + I + ++ V+ S LL Sbjct: 374 HSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIP-LQTKVAAVSLDITSQLL 432 Query: 103 VSASDDKTLKI 113 VS SD +TL + Sbjct: 433 VS-SDGETLYV 442 >5BJS-A nrPDB Length = 605 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 52/95 (54%), Gaps = 7/95 (7%) Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSSGK------C 121 +K++ +GK +T+ GH GI+D+A S ++ ++ SASDD T++IW ++ C Sbjct: 160 VKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVC 219 Query: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + +GHS + F+ ++S D+ + +W Sbjct: 220 ILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 56/109 (51%), Gaps = 7/109 (6%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV-SGSFDESVRI 155 +D LL A ++ +K+++V+ GK +TL GH + +P + I+ S S D ++RI Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 156 WDVKTGK------CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 W + C+ HS + +V F+ +G ++S+ +D + +W Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 49/105 (46%), Gaps = 16/105 (15%) Query: 235 DNTLKLWDYSKGKCLKTYTGHK---NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291 + +K+++ ++GK +T GH N+ AN + I S S+D + IW+L + Sbjct: 157 EGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYI-----IASASDDTTIRIWSLAPE 211 Query: 292 EIVQKL------QGHTDVVISTACHPTENIIASAALENDKTIKLW 330 Q +GH+ ++S A H + SA +D+ I LW Sbjct: 212 HEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAG--HDQVINLW 254 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 19/30 (63%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIW 72 GH+ + SV F NG ++ S+ D++I +W Sbjct: 225 GHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 >5WLC-LU nrPDB Length = 489 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 40/155 (25%), Positives = 77/155 (49%), Gaps = 5/155 (3%) Query: 48 VSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSA 105 ++S+KF+ N + LAS+ +D I ++ + I + + + W+ ++ V+A Sbjct: 222 ITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFNFVTA 280 Query: 106 SDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164 ++D +D+ + + L K H + V +F+P + IV+GS+D+S+RI+ G Sbjct: 281 NEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSR 340 Query: 165 KTLPA-HSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + V V ++ D I+S S DG R+W Sbjct: 341 EIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/184 (22%), Positives = 86/184 (46%), Gaps = 17/184 (9%) Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTG----KCLK 165 + +WDV+ K + L ++ + FN +++++ S D S+ ++D++T K ++ Sbjct: 201 IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQ 260 Query: 166 TLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 T+ ++ +P+ A +F V+++ D +D + + D V V F Sbjct: 261 TMRTNAICWNPMEAFNF-------VTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDF 313 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 SP G I+ + D +++++ + G + Y H +F K+I+SGS+D Sbjct: 314 SPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQHVFQVKYSMDSKYIISGSDDGN 371 Query: 283 VYIW 286 V +W Sbjct: 372 VRLW 375 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 39/75 (52%), Gaps = 1/75 (1%) Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCNFNPQSNLI 144 H + DV +S + +V+ S DK+++I+ + G + +VF ++ S I Sbjct: 304 HVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYI 363 Query: 145 VSGSFDESVRIWDVK 159 +SGS D +VR+W K Sbjct: 364 ISGSDDGNVRLWRSK 378 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 62/286 (21%), Positives = 122/286 (42%), Gaps = 52/286 (18%) Query: 85 GHKLGISDVAWSSDS-NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CCNFNPQ-- 140 GH+ G+ +A + S N L + S D +K W++S+ + + K H V C P+ Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 141 --------SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV---SS 189 N ++S S D++V++W + + +D V+ N +G + S Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVT----NEEGLIRTFDGES 180 Query: 190 SYDGL---------------CRIWDTASGQCLKTLID----DDNPPVSFVKFSPNGKYIL 230 ++ G+ +WD LK + D DN ++ +KF+ N IL Sbjct: 181 AFQGIDSHRENSTFATGGAKIHLWDV---NRLKPVSDLSWGADN--ITSLKFNQNETDIL 235 Query: 231 AAT-LDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 A+T DN++ L+D + K + C ++ V+ +ED+ Y +++ Sbjct: 236 ASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAIC----WNPMEAFNFVTANEDHNAYYYDM 291 Query: 289 QT-KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 + + + H V+ PT + I + + DK+I+++K++ Sbjct: 292 RNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSY--DKSIRIYKTN 335 >5CXC-A nrPDB Length = 510 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 70/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 55 PNGEWLASSSADKLIKIWGAYDGKFEKTISG----HKLGISDVAWSSDSNLLVSASDDKT 110 P E + S+S D L++IW A + SG H I + + S+ L SA D+T Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLT-SDRLASAGMDRT 214 Query: 111 LKIW-----DVSSGKCLKTLK--GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163 +++W D +G+ TL+ GH+ V + + S I++ S D ++ W Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASA 274 Query: 164 LK----TLPA--------------------------HSDPVSAVHFN-RDGSLIVSSSYD 192 + LP H+ P +A F+ RD ++ S+S D Sbjct: 275 PEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQD 334 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG---KYILAATLDNTLKLWD---YSKG 246 R D +GQ + TL +P +S + G + A T + + D S Sbjct: 335 HTVRTLDLTTGQVVSTLT-LTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSAT 393 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG 299 + T GH N+ + + S +VSGS D +W+L++ K +G Sbjct: 394 TSVMTLRGHANK--VVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEG 444 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 47/206 (22%), Positives = 81/206 (39%), Gaps = 46/206 (22%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW----------------GAYDGKFEKT 82 L GHT +V + + + + ++SAD I W GA+ K K Sbjct: 234 LELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKA 293 Query: 83 ISG------HKLGISDVAWS-------------SDSNLLVSASDDKTLKIWDVSSGKCLK 123 S LG+ WS D + SAS D T++ D+++G+ + Sbjct: 294 TSSVSTAQRGPLGL----WSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVS 349 Query: 124 TLKGHSNYVFCCNF---NPQSNLIVSGSFDESVRIWDVKTGKC---LKTLPAHSDPVSAV 177 TL + S L+ +G+ + + D + + TL H++ V ++ Sbjct: 350 TLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSL 409 Query: 178 HFNRDGSL-IVSSSYDGLCRIWDTAS 202 + + +VS S+DG CR+WD S Sbjct: 410 SPSPENEYSLVSGSHDGTCRVWDLRS 435 >4XFV-A nrPDB Length = 792 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 90/217 (41%), Gaps = 28/217 (12%) Query: 102 LVSASDDKTLKIWDV---SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 156 +V+ KT+ +WD ++ TLKGH V C F P S+ +VS S D V+IW Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 92 Query: 157 -DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 D +C++T+ +S + A+ + SLI DG IW L + Sbjct: 93 TDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 150 Query: 216 PVSFVKFSP---------NGKYILAATLDN------TLKLWDYSKGKC--LKTYTGHKN- 257 F F P KY+LA N + L D KC + GH++ Sbjct: 151 KKGF--FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 208 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294 K F + G + SGS+D + +W ++ +++ Sbjct: 209 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 245 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 94/233 (40%), Gaps = 28/233 (12%) Query: 30 PVKPN-YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HK 87 P++PN + TL GH V+ V+F P+ +++ S+S D +KIW D + I Sbjct: 47 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 106 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIW------DVSSGKCLKTLKGHSNYVFCCNFNPQS 141 + VA S+ +L+ D T+ IW D T+K Y C + + Sbjct: 107 YSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE 166 Query: 142 N----LIVSGS----FDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGS----LIV 187 L + G+ F S + D KC + L H D V ++ F + L+ Sbjct: 167 EKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLC 226 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240 S S D R+W + LIDD + N +Y +D+ L++ Sbjct: 227 SGSQDRYIRLWRIR----INDLIDDSEEDSKKLTLLSNKQYKFQ--IDDELRV 273 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 91/211 (43%), Gaps = 28/211 (13%) Query: 144 IVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-- 198 IV+ +++ +WD TL H V+ V F D +VS+S D +IW Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 92 Query: 199 -DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS----KGKCLKTYT 253 D + QC++T+ + + V S I D T+ +W + + +T Sbjct: 93 TDYSHLQCIQTI---QHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 149 Query: 254 GHKNEKYCIFANFS-VTGGKWIVSGSEDNL-VYIWN-------LQTKEIVQKLQGHTDVV 304 K Y + + S V K++++ N+ V+I + ++ +V +L+GH D V Sbjct: 150 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 209 Query: 305 ISTACH----PTENIIASAALENDKTIKLWK 331 S A P + ++ S + D+ I+LW+ Sbjct: 210 KSLAFRHQETPGDYLLCSGS--QDRYIRLWR 238 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 7/85 (8%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFE---KTISGHKLGIS 91 +K L H+ ++ +KFS +G++L S D+ +W D FE K H I Sbjct: 602 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 661 Query: 92 DVAWS--SDSNLLVSASDDKTLKIW 114 D W+ N+ V+AS DKT+K+W Sbjct: 662 DADWAPLEFGNVFVTASRDKTVKVW 686 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 46/220 (20%), Positives = 95/220 (43%), Gaps = 28/220 (12%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSS-----ADKLIKIWGAYDG-KFEKTISGHKLGISDVA 94 L GH ++ + SP+ + +AS+ + +I+I+ + + + + H L I+ + Sbjct: 558 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 617 Query: 95 WSSDSNLLVSASDDKTLKIW-----DVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSG 147 +S D L+S D+ +W D + K K H+ ++ ++ P N+ V+ Sbjct: 618 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 677 Query: 148 SFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFN----RDGSLIVSSSYDGLCRIWD 199 S D++V++W + L+ H+ V+A+ + R+ LI +G ++ Sbjct: 678 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 737 Query: 200 TASGQC-LKTLIDDDNPP------VSFVKFSPNGKYILAA 232 G+ L T +++D P + + NGK L Sbjct: 738 YTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGV 777 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 108/292 (36%), Gaps = 77/292 (26%) Query: 41 LAGHTKAVSSVKF----SPNGEWLASSSADKLIKIW----------GAYDGK-------- 78 L GH V S+ F +P L S S D+ I++W D K Sbjct: 202 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 261 Query: 79 ---------------FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKC 121 FE I GH IS + W L++A+ D +L +W D +SG Sbjct: 262 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 321 Query: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181 + +L+ S+ S + S W CL D Sbjct: 322 VCSLR----------LGEMSSKGASTATGSSGGFW-----SCLWFTHERMD--------- 357 Query: 182 DGSLIVSSSYDGLCRIWDTASGQ-CLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLK 239 +++ G R+W T C + L I V+ + +SP+G+Y+LA +LD T + Sbjct: 358 ---FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTR 414 Query: 240 L---WDY-SKGKCLKTYTGHKNEK-----YCIFANFSVTGGKWIVSGSEDNL 282 L W Y + G+ + T H+ + Y + +VT +++ G E L Sbjct: 415 LFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKIL 466 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 82/178 (46%), Gaps = 20/178 (11%) Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSY-----DGLCRIWDTASGQCLKTLIDDDNPPVS 218 ++ L H ++ + + D LI S+ + + RI+ T + +K + + ++ Sbjct: 555 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 614 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT-GHKNEK---YCIF-ANFS-VTGGK 272 +KFS +GK++L+ D LW+ + T+ KNEK I+ A+++ + G Sbjct: 615 RLKFSKDGKFLLSVCRDRKWALWERNMED--NTFELRFKNEKPHTRIIWDADWAPLEFGN 672 Query: 273 WIVSGSEDNLVYIWNLQTKE----IVQKLQGHTDVVISTACHPT---ENIIASAALEN 323 V+ S D V +W Q + +++ HT V + + H + E I+ S LEN Sbjct: 673 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 730 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 46/93 (49%), Gaps = 11/93 (11%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG--AYD--GKFEKTISGHKLGISDV 93 + ++G TK V+ + +SP+GE+L ++S D+ +++ YD G+ + + H+ + Sbjct: 382 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 441 Query: 94 -------AWSSDSNLLVSASDDKTLKIWDVSSG 119 + VS D+K L+ +D+ G Sbjct: 442 HGYDMICVETVTDTRFVSGGDEKILRSFDLPKG 474 >3JRP-A nrPDB Length = 379 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/239 (23%), Positives = 106/239 (44%), Gaps = 24/239 (10%) Query: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSA 176 G + H+ + + + + S D++++I++V+ T K + TL H PV Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 177 VHFN--RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILA 231 V + + G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 120 Query: 232 ATLDNTLKLWDYSKGK-----CLKTYTGHKNEKYCIFANFSVTG-------GKWIVSGSE 279 A+ D + + ++ + + + N A G + V+G Sbjct: 121 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 180 Query: 280 DNLVYIW----NLQTKEIVQKLQGHTDVVISTACHPTENIIAS-AALENDKTIKLWKSD 333 DNLV IW + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 181 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 239 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 60/152 (39%), Gaps = 22/152 (14%) Query: 60 LASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSSDSNL---LVSASDDKTLK 112 + AD L+KIW A E T+ GH + DVAWS L L S S D+T Sbjct: 175 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 234 Query: 113 IW--DVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 IW D G KTL + ++ +++ N++ D V +W + L Sbjct: 235 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK-------ENL 287 Query: 168 PAHSDPVSAVH---FNRDGSLIVSSSYDGLCR 196 +P VH G S +DG C+ Sbjct: 288 EGKWEPAGEVHQGGGGSGGGGATSKEFDGPCQ 319 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 41/286 (14%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSSD- 98 H + + G+ LA+ S+DK IKI+ +G+ K T++GH+ + V W+ Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIF-EVEGETHKLIDTLTGHEGPVWRVDWAHPK 67 Query: 99 -SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESV 153 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 68 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 127 Query: 154 RIWDVKTGKCLK--TLPAHSDPVSAVHF-------------NRDGSLIVSSSYDGLCRIW 198 + + K + AH+ V++ + ++ V+ D L +IW Sbjct: 128 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 Query: 199 ---DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLK 250 A L++ ++ + V V +SP Y+ + + D T +W D +G K Sbjct: 188 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 247 Query: 251 TYTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIW--NLQTK 291 T K EK+ A++S++G +SG DN V +W NL+ K Sbjct: 248 TLL--KEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKENLEGK 290 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 10/89 (11%) Query: 35 YALKFTLAGHTKAVSSVKFSPN---GEWLASSSADKLIKIWGA--YDGKFEKTISGHKLG 89 Y L+ TL GH+ V V +SP +LAS S D+ IW G ++KT+ + Sbjct: 196 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE-K 254 Query: 90 ISDV----AWSSDSNLLVSASDDKTLKIW 114 DV +WS N+L + D + +W Sbjct: 255 FPDVLWRASWSLSGNVLALSGGDNKVTLW 283 >4BZK-B nrPDB Length = 297 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 104/230 (45%), Gaps = 24/230 (10%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVHFN--RDG 183 H+ + + + + S D++++I++V+ T K + TL H PV V + + G Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTLKL 240 +++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ D + + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 241 WDYSKGK-----CLKTYTGHKNEKYCIFANFSVTG-------GKWIVSGSEDNLVYIW-- 286 ++ + + + N A G + V+G DNLV IW Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 287 --NLQTKEIVQKLQGHTDVVISTACHPTENIIAS-AALENDKTIKLWKSD 333 + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 70/285 (24%), Positives = 121/285 (42%), Gaps = 41/285 (14%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSSD-- 98 H + + G+ LA+ S+DK IKI+ +G+ K T++GH+ + V W+ Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIF-EVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 99 SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVR 154 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 155 IWDVKTGKCLK--TLPAHSDPVSAVHF-------------NRDGSLIVSSSYDGLCRIW- 198 + + K + AH+ V++ + ++ V+ D L +IW Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 199 --DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLKT 251 A L++ ++ + V V +SP Y+ + + D T +W D +G KT Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 252 YTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIW--NLQTK 291 K EK+ A++S++G +SG DN V +W NL+ K Sbjct: 247 LL--KEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKENLEGK 288 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 53/131 (40%), Gaps = 19/131 (14%) Query: 60 LASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSSDSNL---LVSASDDKTLK 112 + AD L+KIW A E T+ GH + DVAWS L L S S D+T Sbjct: 173 FVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCI 232 Query: 113 IW--DVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 IW D G KTL + ++ +++ N++ D V +W + L Sbjct: 233 IWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK-------ENL 285 Query: 168 PAHSDPVSAVH 178 +P VH Sbjct: 286 EGKWEPAGEVH 296 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 10/89 (11%) Query: 35 YALKFTLAGHTKAVSSVKFSPN---GEWLASSSADKLIKIWGA--YDGKFEKTISGHKLG 89 Y L+ TL GH+ V V +SP +LAS S D+ IW G ++KT+ + Sbjct: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE-K 252 Query: 90 ISDV----AWSSDSNLLVSASDDKTLKIW 114 DV +WS N+L + D + +W Sbjct: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >3JZG-A nrPDB Length = 402 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 10/132 (7%) Query: 94 AWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGS 148 AW+ DSN LL A ++I + + +C+K GH N + F+P+ NL++S S Sbjct: 112 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 171 Query: 149 FDESVRIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 D ++R+W+++T + + H D V + ++ G I+S D ++W S + Sbjct: 172 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 231 Query: 206 LKTLID--DDNP 215 + + + D NP Sbjct: 232 MNAIKESYDYNP 243 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 26/117 (22%), Positives = 57/117 (48%), Gaps = 4/117 (3%) Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 118 LA + + +I+I + K GH I+++ + D NLL+S S D L++W++ + Sbjct: 124 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 183 Query: 119 GKCLKT---LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 + ++GH + V +++ I+S D S+++W + + + + + D Sbjct: 184 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 240 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 20/186 (10%) Query: 162 KCLKTLPA-HSDPVSAVHFN---RDGSLIV----SSSYDGLCRIWDTASGQCLKTLID-- 211 KC+ +L H+ P+ V FN ++G +V S+ L + L++ +D Sbjct: 44 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 103 Query: 212 -DDNPPVSFVKFSPNGKYILAATLDN--TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 D+N + N + L A + +++ + +C+K Y GH N + F Sbjct: 104 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KFHP 161 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQ---KLQGHTDVVISTACHPTENIIASAALENDK 325 ++S S+D+ + +WN+QT +V ++GH D V+S I S + D Sbjct: 162 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM--DH 219 Query: 326 TIKLWK 331 ++KLW+ Sbjct: 220 SLKLWR 225 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 6/95 (6%) Query: 42 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 GH A++ +KF P + L S S D +++W G + G D S+D + Sbjct: 148 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE-GHRDEVLSADYD 206 Query: 101 LL----VSASDDKTLKIWDVSSGKCLKTLKGHSNY 131 LL +S D +LK+W ++S + + +K +Y Sbjct: 207 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 241 Score = 34.7 bits (78), Expect = 0.058, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 65/140 (46%), Gaps = 13/140 (9%) Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGK----YILAATLDNTLKLWD-YSKG--KCLKTYT- 253 S +C+ +L +D N P+ V+F+ + K + A N + L++ +S+G + L++Y Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 254 --GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 +N C + S T + ++ I N T + ++ GH + + HP Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 161 Query: 312 TE-NIIASAALENDKTIKLW 330 + N++ S + D ++LW Sbjct: 162 RDPNLLLSVS--KDHALRLW 179 Score = 27.3 bits (59), Expect = 8.5, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%), Gaps = 2/36 (5%) Query: 82 TISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWD 115 T++ HK G I ++S DS++L++ DD ++ WD Sbjct: 364 TLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 >4G56-B nrPDB Length = 357 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 8/120 (6%) Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSN 142 + G++DVAW S+ +LV ASD +++W++ + L K H + V + Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDT 200 VSG D SV++WD+ LK+ AHS V+ V +D ++ +S DG +WDT Sbjct: 153 QAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKD-TIFLSCGEDGRILLWDT 211 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 2/107 (1%) Query: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYI 285 K IL A+ ++LW+ + + L K E I SV + G VSG +D V + Sbjct: 106 KGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKV 165 Query: 286 WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 W+L K +++ H+ V A P ++ I + E D I LW + Sbjct: 166 WDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGE-DGRILLWDT 211 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 1/67 (1%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRI 155 SD VS D ++K+WD+S LK+ HS+ V C P + + +S D + + Sbjct: 149 SDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILL 208 Query: 156 WDVKTGK 162 WD + K Sbjct: 209 WDTRKPK 215 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 4/66 (6%) Query: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI-VSGSEDNLV 283 +G ++ D ++K+WD S+ LK+Y H +E C+ A G I +S ED + Sbjct: 150 DGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAA---CPGKDTIFLSCGEDGRI 206 Query: 284 YIWNLQ 289 +W+ + Sbjct: 207 LLWDTR 212 >6E29-D nrPDB Length = 345 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 60/324 (18%), Positives = 129/324 (39%), Gaps = 41/324 (12%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101 +GH+ + V+F+ G++LAS D + IW + + GH I+ ++WS Sbjct: 25 SGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRY 81 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWD--- 157 L+SA + +WD+ GK + ++ + V+ +P + + F++ + D Sbjct: 82 LLSACQGWKVILWDLQDGKRYREVRFRAP-VYGAELHPWNHHQFAAALFEDQPMLVDITE 140 Query: 158 -VKTGKCLKTLP----AHSDPV--------------SAVHFNRDGSLIVSSSYDGLCRIW 198 V+ L ++P +DP +A+ + G +++ + G I Sbjct: 141 PVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNII 200 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW------------DYSKG 246 D + + + + + ++ ++ + +G+ +L D ++ + D + Sbjct: 201 DARTREIIYSE-KIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQL 259 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 + N FS TG S ++ +YIW +V+ L+G + Sbjct: 260 PLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGV 319 Query: 307 TACHPTENIIASAALENDKTIKLW 330 HP ++A+ LE + I +W Sbjct: 320 IEWHPHRALLAACGLETGR-INIW 342 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 65/135 (48%), Gaps = 9/135 (6%) Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 NLL+S DD L+ + + +++ GHS C FN + + + SG D +V IWD++ Sbjct: 3 NLLLS--DDYLLQDYPENITNTIRS--GHST---CVRFNRKGDFLASGRVDGTVVIWDLE 55 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 T + L HS ++++ ++R G ++S+ +WD G+ + + PV Sbjct: 56 TMGVARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREV--RFRAPVYG 113 Query: 220 VKFSPNGKYILAATL 234 + P + AA L Sbjct: 114 AELHPWNHHQFAAAL 128 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 48/258 (18%), Positives = 99/258 (38%), Gaps = 36/258 (13%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK------FEKTISGHKLGISD-- 92 L GH+K ++S+ +S G +L S+ + +W DGK F + G +L + Sbjct: 63 LRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHH 122 Query: 93 ---VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-----------KGHSNYVFCCNFN 138 A D +LV ++ ++ S K T + + + Sbjct: 123 QFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYT 182 Query: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 + +++G+ + I D +T + + + S ++ + G ++ ++ D + R + Sbjct: 183 ASGDHLLAGTTKGRLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTF 242 Query: 199 DTASGQCLKTLIDDDNPPV-------------SFVKFSPNGKYILAATLDN-TLKLWDYS 244 + D P+ + V FS G+Y+ A+T +N L +W+ Sbjct: 243 IVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERG 302 Query: 245 KGKCLKTYTGHKNEKYCI 262 G ++ G K E+ I Sbjct: 303 HGSLVRMLEGPKEEQGVI 320 Score = 34.7 bits (78), Expect = 0.060, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 6/67 (8%) Query: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG 299 L DY + +GH C+ N G ++ SG D V IW+L+T + +KL+G Sbjct: 12 LQDYPENITNTIRSGHST---CVRFNRK---GDFLASGRVDGTVVIWDLETMGVARKLRG 65 Query: 300 HTDVVIS 306 H+ + S Sbjct: 66 HSKNITS 72 >4L9O-A nrPDB Length = 349 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 104/224 (46%), Gaps = 20/224 (8%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KTGKCLKTLPAHSDPVSAVHFN--RDG 183 H + + + + + S D++++I+++ + + ++TL H PV V + + G Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFG 127 Query: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTLKL 240 ++ S SYDG IW +G K V+ V ++P+ G +L A+ D + + Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 Query: 241 WDYSKGKCLK--TYTGHK-NEKYCIFANFSVTGG-KWIVSGSEDNLVYIWNLQ--TKEIV 294 ++ G L+ GH +A S+ + VSG DNLV IW K + Sbjct: 188 VEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFI 247 Query: 295 QK--LQGHTDVVISTACHP---TENIIASAALENDKTIKLWKSD 333 ++ QGH+D V A P +++ IA+A+ D+T+ +W D Sbjct: 248 EEEAFQGHSDWVRDVAWSPSRLSKSYIATAS--QDRTVLIWTKD 289 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 113/255 (44%), Gaps = 25/255 (9%) Query: 102 LVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNF-NPQSNLIV-SGSFDESVRIWD 157 L + S DKT+KI+++ + + ++TL GH V+ + +P+ +I+ S S+D V IW Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 158 VKTGKCLKTLP--AHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 G K H V++V + + G +++ +S DG I + G L+ ++ Sbjct: 144 EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQG 203 Query: 214 NP-PVSFVKFSP-----NGKYILAATLDNTLKLWDYSKGKCL----KTYTGHKNEKYCIF 263 + V+ ++P N + ++ DN +K+W Y + + GH + + Sbjct: 204 HAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVA 263 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT-----DVVISTACHPTENIIAS 318 + S +I + S+D V IW K + Q T DV + + N++A Sbjct: 264 WSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAI 323 Query: 319 AALENDKTIKLWKSD 333 + D + LWK + Sbjct: 324 SG--GDNKVTLWKEN 336 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 12/88 (13%) Query: 39 FTLAGHTKAVSSVKFSP-----NGEWLASSSADKLIKIWGAYDGK----FEKTISGHKLG 89 + GH V++ ++P N S D L+KIW D E+ GH Sbjct: 199 IVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDW 258 Query: 90 ISDVAWSSDS---NLLVSASDDKTLKIW 114 + DVAWS + + +AS D+T+ IW Sbjct: 259 VRDVAWSPSRLSKSYIATASQDRTVLIW 286 >5N4A-A nrPDB Length = 771 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 38/155 (24%), Positives = 73/155 (47%), Gaps = 3/155 (1%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99 ++ GH A S+++S +G LA++ D +KIW + +G T++ + + W+ D Sbjct: 99 SIEGHKGACISLRWSYDGTALATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWAYDC 157 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 + L + + I +SS K H V +++P ++LI++G D ++WD Sbjct: 158 DQLCYCTGSNVV-IKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD-S 215 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194 G+ L PV++V + G L ++ L Sbjct: 216 FGRLLFQSGLFDYPVTSVAWAPSGELFAVGGFNTL 250 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 95/211 (45%), Gaps = 18/211 (8%) Query: 44 HTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 H VSS K G + A + D +KI + G+ EK+I GHK + WS D L Sbjct: 61 HWYPVSSKKTQAGGTDVFAVACTDGSVKIL-SRTGRVEKSIEGHKGACISLRWSYDGTAL 119 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSN---YVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 +A +D ++KIW S L++ ++ Y ++ +GS +V I + Sbjct: 120 ATAGEDGSVKIW--SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGS---NVVIKSLS 174 Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 + AH V V ++ LI++ D ++WD+ ++ + D PV+ Sbjct: 175 SNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFD--YPVTS 232 Query: 220 VKFSPNGKYILAATLDNTLKL-----WDYSK 245 V ++P+G+ + A NTL+L W YSK Sbjct: 233 VAWAPSGE-LFAVGGFNTLQLCDRMGWAYSK 262 >5K19-A nrPDB Length = 569 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 55/114 (48%), Gaps = 2/114 (1%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 N LK+T+ A++ FSP+G++LA S D ++++ + T+ + G+ V Sbjct: 211 NPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 WS D +V+ +D + +W + + GH ++V F+P + + G Sbjct: 269 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 3/90 (3%) Query: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 FSP+GK++ + D L+++++ + T + C+ + GK+IV+G ED+ Sbjct: 228 FSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS---PDGKYIVTGGEDD 284 Query: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 LV +W+ ++ + GH V A P Sbjct: 285 LVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/91 (25%), Positives = 43/91 (47%) Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 +++ A+S D L S D L++++ S + T+K + + C ++P IV+G Sbjct: 223 LNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE 282 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 D+ V +W + + H VS V F+ Sbjct: 283 DDLVTVWSFVDCRVIARGHGHKSWVSVVAFD 313 Score = 34.7 bits (78), Expect = 0.059, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 1/79 (1%) Query: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 F+ DG + S DG R+++ S + L + + V +SP+GKYI+ D+ + Sbjct: 228 FSPDGKFLACVSQDGFLRVFNFDSVE-LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLV 286 Query: 239 KLWDYSKGKCLKTYTGHKN 257 +W + + + GHK+ Sbjct: 287 TVWSFVDCRVIARGHGHKS 305 >5YZG-2 nrPDB Length = 646 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/218 (22%), Positives = 91/218 (41%), Gaps = 24/218 (11%) Query: 58 EWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115 +++ ++S D +K W + +F K H I +A SS+ L S DDK +K++D Sbjct: 102 DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFD 161 Query: 116 VSSGKCLKTLK-----GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK-TGKCLKTL-P 168 V + + LK G +++C + S++ S + I+D + + L Sbjct: 162 VVNFDMINMLKLGYFPGQCEWIYCPG-DAISSVAASEKSTGKIFIYDGRGDNQPLHIFDK 220 Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-----DTASGQCLKTLIDDDNPPVSFVK-- 221 H+ P++ + N +VSS G+ W + + + D F K Sbjct: 221 LHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCK 280 Query: 222 -------FSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 FSP+GK I D ++++ + GK ++ + Sbjct: 281 AYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVF 318 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 3/53 (5%) Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 E VY+ NL + + ++ H DV+ C T+ II ++ +D +K WK Sbjct: 68 EFERVYLDNLPSASMYERSYMHRDVITHVVCTKTDFIITAS---HDGHVKFWK 117 >3JRO-A nrPDB Length = 753 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 104/231 (45%), Gaps = 24/231 (10%) Query: 127 GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVHFN--RD 182 H+ + + + + S D++++I++V+ T K + TL H PV V + + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTLK 239 G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ D + Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 240 LWDYSKGK-----CLKTYTGHKNEKYCIFANFSVTG-------GKWIVSGSEDNLVYIW- 286 + ++ + + + N A G + V+G DNLV IW Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 287 ---NLQTKEIVQKLQGHTDVVISTACHPTENIIAS-AALENDKTIKLWKSD 333 + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 47/168 (27%), Positives = 64/168 (38%), Gaps = 29/168 (17%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSSDS 99 H S KF G AD L+KIW A E T+ GH + DVAWS Sbjct: 164 HNGTKESRKFVTGG-------ADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 100 NL---LVSASDDKTLKIW--DVSSGKCLKTLKGHSNY---VFCCNFNPQSNLIVSGSFDE 151 L L S S D+T IW D G KTL + ++ +++ N++ D Sbjct: 217 LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDN 276 Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVH---FNRDGSLIVSSSYDGLCR 196 V +W + L +P VH G S +DG C+ Sbjct: 277 KVTLWK-------ENLEGKWEPAGEVHQGGGGSGGGGATSKEFDGPCQ 317 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 41/286 (14%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---TISGHKLGISDVAWSSD- 98 H + + G+ LA+ S+DK IKI+ +G+ K T++GH+ + V W+ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 99 -SNLLVSASDDKTLKIWDVSSGK--CLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESV 153 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 154 RIWDVKTGKCLK--TLPAHSDPVSAVHF-------------NRDGSLIVSSSYDGLCRIW 198 + + K + AH+ V++ + ++ V+ D L +IW Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 199 ---DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLK 250 A L++ ++ + V V +SP Y+ + + D T +W D +G K Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 Query: 251 TYTGHKNEKY---CIFANFSVTGGKWIVSGSEDNLVYIW--NLQTK 291 T K EK+ A++S++G +SG DN V +W NL+ K Sbjct: 246 TLL--KEEKFPDVLWRASWSLSGNVLALSGG-DNKVTLWKENLEGK 288 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 10/89 (11%) Query: 35 YALKFTLAGHTKAVSSVKFSPN---GEWLASSSADKLIKIWGA--YDGKFEKTISGHKLG 89 Y L+ TL GH+ V V +SP +LAS S D+ IW G ++KT+ + Sbjct: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE-K 252 Query: 90 ISDV----AWSSDSNLLVSASDDKTLKIW 114 DV +WS N+L + D + +W Sbjct: 253 FPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >3W15-A nrPDB Length = 368 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 40/154 (25%), Positives = 68/154 (44%), Gaps = 19/154 (12%) Query: 98 DSNLLVSASDDKTLKIWDVS--SGKCLKTLKGHSNY-VFCCNFNPQSNLIV-SGSFDESV 153 D NL++S S + ++D+ SGK HS C+FN +V +G D ++ Sbjct: 188 DQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAI 247 Query: 154 RIWDVK----------TGKCLKTLP-AHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTA 201 RIWD++ C+ +P AH + V ++ ++++S+SYD CRIW Sbjct: 248 RIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDL 307 Query: 202 SGQCLKTLI---DDDNPPVSFVKFSPNGKYILAA 232 S K D S F+ + +++ A Sbjct: 308 SNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGA 341 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/207 (22%), Positives = 85/207 (41%), Gaps = 37/207 (17%) Query: 90 ISDVAWS-SDSNLLVSASDDKTLKIWDVSSGKC-LKTLKGHSNYVFCCNFN-PQSNLIVS 146 + D+AW+ S N ++ A D TL+++D + + + K H VF CN+N +S Sbjct: 65 LFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLS 124 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHS-------DPVSAVHFNR------------------ 181 S+D S++IW + L TL DP++A+ + Sbjct: 125 SSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQF 184 Query: 182 ---DGSLIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLD 235 D +L++S S + ++D SG+ + F+ Y++A +D Sbjct: 185 SPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVD 244 Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCI 262 N +++WD + L G + CI Sbjct: 245 NAIRIWDI---RMLNKNPGQLHNSSCI 268 >2PM9-A nrPDB Length = 416 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 60/297 (20%), Positives = 122/297 (41%), Gaps = 31/297 (10%) Query: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSS 118 A+ S D +++W EK I+ ++ +D+ WS ++ ++ A D+ +L+++ + Sbjct: 39 ANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNE 98 Query: 119 GK----CLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKCLKT------- 166 + HS+ V FN Q N++ SG + + IWD+ KC ++ Sbjct: 99 ANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMN--KCTESPSNYTPL 156 Query: 167 LPAHS----DPVSAVHFNRD-GSLIVSSSYDGLCRIWDT-ASGQCLKTLIDDDNPPV--- 217 P S D V ++ +N+ + S+ IWD A + + N + Sbjct: 157 TPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQ 216 Query: 218 -SFVKFSP-NGKYILAAT---LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 S V++ P N + AT D ++ +WD ++K + ++ Sbjct: 217 LSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEH 276 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP-TENIIASAALENDKTIK 328 ++S DN V +WN ++ E + + + T P ++ A A+ +N ++ Sbjct: 277 LLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQ 333 >5FA5-B nrPDB Length = 367 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 95/227 (41%), Gaps = 19/227 (8%) Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK----GHSNYVFCCNFNPQSNLI 144 G++D+ W + +LV ASD +++W++ + L K H + V + Sbjct: 107 GVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQA 165 Query: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASG 203 VSGS D +++WD+ L + AH+ V+ V + S+ +S S D +WDT Sbjct: 166 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDT--- 222 Query: 204 QCLK--TLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 +C K + I P P S + + + T+ L D C+ + H Sbjct: 223 RCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQ- 281 Query: 259 KYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304 C+ FS ++ S SED + + + E+ + Q H D V Sbjct: 282 --CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 325 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 2/109 (1%) Query: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYI 285 + IL A+ ++LW+ + + L K E I + SV + G VSGS+D + + Sbjct: 117 RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKV 176 Query: 286 WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 W+L + ++ + H V A P ++ + + E+++ I LW + C Sbjct: 177 WDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNR-ILLWDTRC 224 >5MC6-j nrPDB Length = 397 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 37/151 (24%), Positives = 65/151 (43%), Gaps = 28/151 (18%) Query: 26 SKPTPVKP--NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83 S+ + ++P N+ + ++ ++ ++ SVKFSP G LA + Y+ +F Sbjct: 212 SELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEF---- 267 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 G ++G +L + SS L HS++V +FN Sbjct: 268 -GERIG--------------------SLSVPTHSSQASLGEF-AHSSWVMSLSFNDSGET 305 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 + S +D +R WDVKT + + TL H D + Sbjct: 306 LCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 32/136 (23%), Positives = 66/136 (48%), Gaps = 24/136 (17%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCL------KTLKGHSNYVFCCNFNPQSNLIV----S 146 S+ L+ + ++ T++I ++S+ + L ++ +SN + F+PQ +L+ S Sbjct: 195 SERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDS 254 Query: 147 GSFDESVRIWDVKTGKCLKTLP-------------AHSDPVSAVHFNRDGSLIVSSSYDG 193 SF + +++ + G+ + +L AHS V ++ FN G + S+ +DG Sbjct: 255 NSFG-CITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDG 313 Query: 194 LCRIWDTASGQCLKTL 209 R WD + + + TL Sbjct: 314 KLRFWDVKTKERITTL 329 >5WLC-LW nrPDB Length = 554 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 67/141 (47%), Gaps = 3/141 (2%) Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 LLV+A + LK DVS+G+ + L+ + NP + ++ G + +V +W Sbjct: 204 LLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSM 263 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 + L L + PV+++ +R G + ++ D +IWD + + L + ++ P + V Sbjct: 264 PEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHS-VESLPTPGTNV 322 Query: 221 KFSPNGKYILAATLDNTLKLW 241 S G +LA + + LW Sbjct: 323 SISDTG--LLALSRGPHVTLW 341 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 3/137 (2%) Query: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 I+D G L LK H +F P L+V+ ++ DV TG+ + L + Sbjct: 176 IYD-HEGTELHRLKQHIE-ARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAG 233 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 P A+ N +++ +G +W + + L L+ PV+ + +G Y+ Sbjct: 234 PTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARG-PVNSIAIDRSGYYMATT 292 Query: 233 TLDNTLKLWDYSKGKCL 249 D ++K+WD K L Sbjct: 293 GADRSMKIWDIRNFKQL 309 >4E5Z-B nrPDB Length = 436 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 67/134 (50%), Gaps = 9/134 (6%) Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVR 154 S+ S ++V+ + + + ++ GK L L+ H V NP + + + S D++V+ Sbjct: 218 SASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVK 276 Query: 155 IWDVKT--GKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 IWD++ GK L +LP H PV+A F+ DG+ ++++ R++ + C LI Sbjct: 277 IWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLI 335 Query: 211 DDDNPPVSFVKFSP 224 +P F +P Sbjct: 336 --PHPHRHFQHLTP 347 Score = 30.8 bits (68), Expect = 0.94, Method: Compositional matrix adjust. Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 8/169 (4%) Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS--NYVFC-CNFNPQSNLIVSGSFDESVR 154 ++N ++S + T ++ D G L+ N FC + + S ++V+G +V Sbjct: 176 NTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVI 234 Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYDGLCRIWDTASGQCLKTLIDD- 212 + ++ GK L L H V+ V N + ++S D +IWD + + + Sbjct: 235 LLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSL 293 Query: 213 -DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260 PV+ FSP+G +L + ++++ S+ C H + + Sbjct: 294 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHF 342 >5LTD-A nrPDB Length = 525 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/170 (21%), Positives = 80/170 (47%), Gaps = 27/170 (15%) Query: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNF-------------------NPQSNLIVSGS 148 ++T+ I+D+++ + L T++ SN NPQ+ + + S Sbjct: 136 EETIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLH-S 194 Query: 149 FDESVR-----IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG-LCRIWDTAS 202 ++VR I+D KT + + AH ++A+ ++DG L+ ++S G + R++ A+ Sbjct: 195 NPQTVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVAT 254 Query: 203 GQCLKTLIDDDNP-PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251 G L P + + FSP+ ++++A++ T+ ++ + + T Sbjct: 255 GIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANT 304 >6EM1-m nrPDB Length = 807 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 27/153 (17%) Query: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTL 167 + ++I+D+S +K L + ++ + +P+ + +++ SFD+ V D+ KTL Sbjct: 660 RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTL 719 Query: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD--DNPPVSFVK---- 221 H V +V+F++ L S++ DG ++ T+ DD NP + +K Sbjct: 720 RYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA-------TVYDDMMKNPMIVPLKKLTG 772 Query: 222 -------------FSPNGKYILAATLDNTLKLW 241 + P ++ +A DNT +LW Sbjct: 773 HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/88 (32%), Positives = 40/88 (45%), Gaps = 13/88 (14%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFE-------KTISGHK--- 87 TL H KAV SV F +S++ D I ++ A YD + K ++GHK Sbjct: 718 TLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVIN 777 Query: 88 -LGISDVAWSSDSNLLVSASDDKTLKIW 114 LG+ D W L SA D T ++W Sbjct: 778 SLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 34.7 bits (78), Expect = 0.067, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 16/124 (12%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYD--GKFEKTISGHKLGISDVAWSSDSNLLVSA 105 +S + P G+ L +SS DK + +W D KT+ H+ + V + L SA Sbjct: 683 LSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSA 741 Query: 106 SDDKTLKIW------DVSSGKC---LKTLKGH----SNYVFCCNFNPQSNLIVSGSFDES 152 +DD T+ ++ D+ LK L GH S V ++P+ + S D + Sbjct: 742 ADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNT 801 Query: 153 VRIW 156 R+W Sbjct: 802 ARLW 805 Score = 34.3 bits (77), Expect = 0.083, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 21/37 (56%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK 78 AGH V ++ P+G WLA+ S D +++W G+ Sbjct: 434 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 470 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 23/43 (53%) Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 +C GH V + +P + +GS D +VR+W++ TG+ Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 470 Score = 31.6 bits (70), Expect = 0.53, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--KTLIDDDNPP--- 216 +C H V + + G + + S DG R+W+ +G+ + TLIDD+ P Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 217 VSFVKFSPNGKY-ILAATLDNTLKL 240 + ++++P+ ILA + + L Sbjct: 488 IECIEWNPDANNGILAVAVGENIHL 512 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 +C Y GHK + + + S G W+ +GS+D V +W + T V + Sbjct: 428 RCSTIYAGHKGKVRTLSIDPS---GLWLATGSDDGTVRVWEILTGREVYR 474 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 14/65 (21%), Positives = 32/65 (49%), Gaps = 6/65 (9%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNF 137 +GHK + ++ L + SDD T+++W++ +G+ + + ++ C + Sbjct: 434 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 493 Query: 138 NPQSN 142 NP +N Sbjct: 494 NPDAN 498 >6CB1-s nrPDB Length = 569 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 27/153 (17%) Query: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTL 167 + ++I+D+S +K L + ++ + +P+ + +++ SFD+ V D+ KTL Sbjct: 422 RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTL 481 Query: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD--DNPPVSFVK---- 221 H V +V+F++ L S++ DG ++ T+ DD NP + +K Sbjct: 482 RYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA-------TVYDDMMKNPMIVPLKKLTG 534 Query: 222 -------------FSPNGKYILAATLDNTLKLW 241 + P ++ +A DNT +LW Sbjct: 535 HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/88 (32%), Positives = 40/88 (45%), Gaps = 13/88 (14%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFE-------KTISGHK--- 87 TL H KAV SV F +S++ D I ++ A YD + K ++GHK Sbjct: 480 TLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVIN 539 Query: 88 -LGISDVAWSSDSNLLVSASDDKTLKIW 114 LG+ D W L SA D T ++W Sbjct: 540 SLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 34.7 bits (78), Expect = 0.059, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 16/124 (12%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYD--GKFEKTISGHKLGISDVAWSSDSNLLVSA 105 +S + P G+ L +SS DK + +W D KT+ H+ + V + L SA Sbjct: 445 LSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSA 503 Query: 106 SDDKTLKIW------DVSSGKC---LKTLKGH----SNYVFCCNFNPQSNLIVSGSFDES 152 +DD T+ ++ D+ LK L GH S V ++P+ + S D + Sbjct: 504 ADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNT 563 Query: 153 VRIW 156 R+W Sbjct: 564 ARLW 567 Score = 34.3 bits (77), Expect = 0.086, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 21/37 (56%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK 78 AGH V ++ P+G WLA+ S D +++W G+ Sbjct: 196 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 232 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 23/43 (53%) Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 +C GH V + +P + +GS D +VR+W++ TG+ Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 232 Score = 31.6 bits (70), Expect = 0.51, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--KTLIDDDNPP--- 216 +C H V + + G + + S DG R+W+ +G+ + TLIDD+ P Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 217 VSFVKFSPNGKY-ILAATLDNTLKL 240 + ++++P+ ILA + + L Sbjct: 250 IECIEWNPDANNGILAVAVGENIHL 274 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 +C Y GHK + + + S G W+ +GS+D V +W + T V + Sbjct: 190 RCSTIYAGHKGKVRTLSIDPS---GLWLATGSDDGTVRVWEILTGREVYR 236 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 14/65 (21%), Positives = 32/65 (49%), Gaps = 6/65 (9%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNF 137 +GHK + ++ L + SDD T+++W++ +G+ + + ++ C + Sbjct: 196 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 255 Query: 138 NPQSN 142 NP +N Sbjct: 256 NPDAN 260 >6C0F-s nrPDB Length = 807 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 69/153 (45%), Gaps = 27/153 (17%) Query: 109 KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC-LKTL 167 + ++I+D+S +K L + ++ + +P+ + +++ SFD+ V D+ KTL Sbjct: 660 RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTL 719 Query: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD--DNPPVSFVK---- 221 H V +V+F++ L S++ DG ++ T+ DD NP + +K Sbjct: 720 RYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA-------TVYDDMMKNPMIVPLKKLTG 772 Query: 222 -------------FSPNGKYILAATLDNTLKLW 241 + P ++ +A DNT +LW Sbjct: 773 HKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/88 (32%), Positives = 40/88 (45%), Gaps = 13/88 (14%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFE-------KTISGHK--- 87 TL H KAV SV F +S++ D I ++ A YD + K ++GHK Sbjct: 718 TLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVIN 777 Query: 88 -LGISDVAWSSDSNLLVSASDDKTLKIW 114 LG+ D W L SA D T ++W Sbjct: 778 SLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 34.3 bits (77), Expect = 0.082, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 21/37 (56%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK 78 AGH V ++ P+G WLA+ S D +++W G+ Sbjct: 434 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 470 Score = 34.3 bits (77), Expect = 0.083, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 16/124 (12%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYD--GKFEKTISGHKLGISDVAWSSDSNLLVSA 105 +S + P G+ L +SS DK + +W D KT+ H+ + V + L SA Sbjct: 683 LSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSA 741 Query: 106 SDDKTLKIW------DVSSGKC---LKTLKGH----SNYVFCCNFNPQSNLIVSGSFDES 152 +DD T+ ++ D+ LK L GH S V ++P+ + S D + Sbjct: 742 ADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNT 801 Query: 153 VRIW 156 R+W Sbjct: 802 ARLW 805 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 23/43 (53%) Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 +C GH V + +P + +GS D +VR+W++ TG+ Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGR 470 Score = 31.6 bits (70), Expect = 0.53, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--KTLIDDDNPP--- 216 +C H V + + G + + S DG R+W+ +G+ + TLIDD+ P Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 217 VSFVKFSPNGKY-ILAATLDNTLKL 240 + ++++P+ ILA + + L Sbjct: 488 IECIEWNPDANNGILAVAVGENIHL 512 Score = 30.4 bits (67), Expect = 0.99, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 +C Y GHK + + + S G W+ +GS+D V +W + T V + Sbjct: 428 RCSTIYAGHKGKVRTLSIDPS---GLWLATGSDDGTVRVWEILTGREVYR 474 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 14/65 (21%), Positives = 32/65 (49%), Gaps = 6/65 (9%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNF 137 +GHK + ++ L + SDD T+++W++ +G+ + + ++ C + Sbjct: 434 AGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEW 493 Query: 138 NPQSN 142 NP +N Sbjct: 494 NPDAN 498 >6CHG-D nrPDB Length = 439 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 48/108 (44%), Gaps = 16/108 (14%) Query: 27 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-- 84 K P K + L+ +A VKFSP G++LA ++ I I YD K I+ Sbjct: 14 KEYPEKLTHTLEVPVAA-----VCVKFSPRGDYLAVGCSNGAIII---YDMDSLKPIAML 65 Query: 85 -----GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS-GKCLKTLK 126 H + V WS+D L S+ D K+WD++ KC + K Sbjct: 66 GTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYK 113 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 41/79 (51%), Gaps = 5/79 (6%) Query: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP----AHSDPVSAVHFNRDGSLIVSS 189 C F+P+ + + G + ++ I+D+ + K + L AH+ V +V ++ DG + SS Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSS 91 Query: 190 SYDGLCRIWD-TASGQCLK 207 D ++WD T +C + Sbjct: 92 GRDWYAKLWDMTQPTKCFQ 110 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 70/165 (42%), Gaps = 24/165 (14%) Query: 173 PVSAV--HFNRDGSLIVSSSYDGLCRIWDTASGQ---CLKTLIDDDNPPVSFVKFSPNGK 227 PV+AV F+ G + +G I+D S + L T V V +S +G+ Sbjct: 27 PVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGR 86 Query: 228 YILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 Y+ ++ D KLWD ++ KC + Y C ++V IV+ E+ Y+ Sbjct: 87 YLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVC----IVTVVEEPTAYVL 142 Query: 287 NLQTK----------EIVQKLQGHTDVVISTAC-HPT-ENIIASA 319 L + E Q + GH ++ AC HPT E+II + Sbjct: 143 TLTDRQNAFHCFPLLEQDQDISGHGYTLV--ACPHPTIESIIITG 185 >3BG0-A nrPDB Length = 316 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 60/240 (25%), Positives = 95/240 (39%), Gaps = 36/240 (15%) Query: 41 LAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWS 96 L GH V V ++ G LAS S D+ + IW +G +EK+ +GH ++ V W+ Sbjct: 53 LRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWA 112 Query: 97 -SDSNLLVS-ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF----- 149 D L+++ S D + + + + K ++ + CN + +V GS Sbjct: 113 PHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPS 172 Query: 150 ---------------DESVRIWDVKTG---KCLKTLPAHSDPVSAVHF----NRDGSLIV 187 D +++W + K + L AHSD V V + S I Sbjct: 173 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 232 Query: 188 SSSYDGLCRIW---DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244 S S DG IW D +S L+ N V V +S + + DN + LW S Sbjct: 233 SCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 Score = 35.4 bits (80), Expect = 0.037, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 32/140 (22%) Query: 28 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKF--EKTIS 84 P+ KPNY +F AS D LIK+W DG++ E+ + Sbjct: 171 PSGQKPNYIKRF---------------------ASGGCDNLIKLWKEEEDGQWKEEQKLE 209 Query: 85 GHKLGISDVAWSSDSNL----LVSASDDKTLKIW---DVSSGK-CLKTLKGHSNYVFCCN 136 H + DVAW+ L + S S D + IW D SS K L ++ V+ + Sbjct: 210 AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVS 269 Query: 137 FNPQSNLIVSGSFDESVRIW 156 ++ +N++ D V +W Sbjct: 270 WSITANILAVSGGDNKVTLW 289 >6IYY-A nrPDB Length = 317 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/136 (25%), Positives = 60/136 (44%), Gaps = 15/136 (11%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKT-----------I 83 FT H V ++P G L +S + L+ G + G + I Sbjct: 113 VFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDI 172 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTL-KIWDVSSGKCLKTLKGHSNY--VFCCNFNPQ 140 H+ +S +A + + +AS+ TL +I+D SSG ++ L+ S ++C NFN Sbjct: 173 PAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQD 232 Query: 141 SNLIVSGSFDESVRIW 156 ++LI S +V I+ Sbjct: 233 ASLICVSSDHGTVHIF 248 >5WLC-SG nrPDB Length = 573 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 42/102 (41%), Gaps = 2/102 (1%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL--KGHSNYVFCC 135 ++E T GH I VA S D +V+ D+ L +W S +K + K V Sbjct: 227 EYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSL 286 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177 F S+ + + D +R + + L+ L H D V + Sbjct: 287 AFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDI 328 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 23/121 (19%), Positives = 54/121 (44%), Gaps = 2/121 (1%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVAWSS 97 T GH + +V SP+G+++ + D+ + +W K I + + +A+ Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 +S+ L ++ D ++ + ++ L+ L GH + V + + G+ D + +W Sbjct: 291 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 350 Query: 158 V 158 + Sbjct: 351 I 351 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 27/125 (21%), Positives = 50/125 (40%), Gaps = 6/125 (4%) Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSP 224 T H D + V + DG +V+ D +W T S +K + D V + F Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLV 283 N + A+ D ++ + ++ L+ GH + I + S + V+ G+ D Sbjct: 291 NSDQLYASCADFKIRTYSINQFSQLEILYGHHD----IVEDISALAMERCVTVGARDRTA 346 Query: 284 YIWNL 288 +W + Sbjct: 347 MLWKI 351 >4J0X-A nrPDB Length = 451 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 42/102 (41%), Gaps = 2/102 (1%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL--KGHSNYVFCC 135 ++E T GH I VA S D +V+ D+ L +W S +K + K V Sbjct: 105 EYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSL 164 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177 F S+ + + D +R + + L+ L H D V + Sbjct: 165 AFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDI 206 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 23/121 (19%), Positives = 54/121 (44%), Gaps = 2/121 (1%) Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVAWSS 97 T GH + +V SP+G+++ + D+ + +W K I + + +A+ Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 +S+ L ++ D ++ + ++ L+ L GH + V + + G+ D + +W Sbjct: 169 NSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWK 228 Query: 158 V 158 + Sbjct: 229 I 229 Score = 31.2 bits (69), Expect = 0.71, Method: Compositional matrix adjust. Identities = 27/125 (21%), Positives = 50/125 (40%), Gaps = 6/125 (4%) Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSP 224 T H D + V + DG +V+ D +W T S +K + D V + F Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLV 283 N + A+ D ++ + ++ L+ GH + I + S + V+ G+ D Sbjct: 169 NSDQLYASCADFKIRTYSINQFSQLEILYGHHD----IVEDISALAMERCVTVGARDRTA 224 Query: 284 YIWNL 288 +W + Sbjct: 225 MLWKI 229 >5A9Q-7 nrPDB Length = 360 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 72/170 (42%), Gaps = 33/170 (19%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTIS--GHKLGIS 91 + + A H + V F +G +A+ S+D+ +K+W + G + T S H + Sbjct: 2 FVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVW 61 Query: 92 DVAWSSDS--NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 V W+ +L S S D+T +W+ G+ L+G S++V ++ L+ Sbjct: 62 RVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWV------KRTTLV----- 110 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 D + DVK P H G ++ + S DG+ RI++ Sbjct: 111 DSRTSVTDVKFA------PKHM-----------GLMLATCSADGIVRIYE 143 Score = 27.3 bits (59), Expect = 9.1, Method: Compositional matrix adjust. Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 20/118 (16%) Query: 35 YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTISG------- 85 YA TL T V + F+PN + + A K ++I+ + E T SG Sbjct: 209 YAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEI 268 Query: 86 --------HKLGISDVAWSSDSNLLVSASDDKTLKIWD---VSSGKCLKTLKGHSNYV 132 H + V+W+ +L S+ DD +++W + + KC LKG+ + V Sbjct: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326 >5AJA-A nrPDB Length = 361 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 37/184 (20%), Positives = 85/184 (46%), Gaps = 19/184 (10%) Query: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY-- 191 CC F+ + ++ G+ +++++V +G+ + H+ ++ + +RDGSL+++S+ Sbjct: 42 CCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWS 101 Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251 L +W S +K +D+ +V+FS + + + T + ++D G L T Sbjct: 102 QPLSALWGMKSVFDMKHSFTEDH----YVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLT 157 Query: 252 Y----TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307 + ++ C A F+ T + G +W++++ + + K ++ IS Sbjct: 158 LFNPDLANNYKRNC--ATFNPTDDLVLNDG------VLWDVRSAQAIHKFDKF-NMNISG 208 Query: 308 ACHP 311 HP Sbjct: 209 VFHP 212 Score = 31.2 bits (69), Expect = 0.74, Method: Compositional matrix adjust. Identities = 45/183 (24%), Positives = 72/183 (39%), Gaps = 48/183 (26%) Query: 44 HTKAVSSVKFSPNGEWLASSS--ADKLIKIWG---AYDGKFEKTISGHKLGISDVAWSSD 98 H A++ ++ S +G L +S+ + L +WG +D K T + V +S Sbjct: 78 HNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHY------VEFSKH 131 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKG---HSNYVF-CCNFNPQSNLI---------- 144 S V + I+D+ +G L TL +NY C FNP +L+ Sbjct: 132 SQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVR 191 Query: 145 --------------VSGSFDES-------VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 183 +SG F + IWD++T L T+PA D V FN G Sbjct: 192 SAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPA-LDQCRVV-FNHTG 249 Query: 184 SLI 186 +++ Sbjct: 250 TVM 252 >4PSX-B nrPDB Length = 401 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 63/252 (25%), Positives = 100/252 (39%), Gaps = 68/252 (26%) Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161 L+S SDD T+ +W+V SG G + VR W+ Sbjct: 176 LLSGSDDHTVALWEVGSG---------------------------GDPTKPVRTWN---- 204 Query: 162 KCLKTLPAHSDPVSA---VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 HSD ++ +FN+D L + S D L +I D + T ID P Sbjct: 205 ------DLHSDIINDNKWHNFNKD--LFGTVSEDSLLKINDVRAN---NTTIDTVKCPQP 253 Query: 219 F--VKFSPNGKYILAAT-LDNTLKLWDYSKGK-CLKTYTGHKNEKYCIFANFSVTGGKWI 274 F + FS + +LAA +D+ + L+D K L +GH++ + FS + Sbjct: 254 FNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNL--EFSTHVDGVV 311 Query: 275 VSGSEDNLVYIWNLQ--------------TKEIVQKLQGHTDVVISTACHPTEN-IIASA 319 VS DN + +W+L+ E++ GH V +P ++ASA Sbjct: 312 VSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASA 371 Query: 320 ALENDKTIKLWK 331 EN +++WK Sbjct: 372 EEEN--ILQVWK 381 >5CXB-B nrPDB Length = 369 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 35/172 (20%), Positives = 79/172 (45%), Gaps = 24/172 (13%) Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 G++ A L + ++++ +D+ + +K ++ + ++ + +P + +V GS Sbjct: 202 GLAQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGS 261 Query: 149 FDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCL 206 +D+ + D+ + + KT+ H++ + AV F++ G L +S DG +I+ G+ Sbjct: 262 YDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIF---HGKVP 318 Query: 207 KTLIDDDNP---PVSFVK--------------FSPNGKYILAATLDNTLKLW 241 + +NP PV +K + P + ++A D T +LW Sbjct: 319 NDQL--ENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 24/100 (24%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFE---------- 80 +P ++F HT+A+ +V+F G A +S D ++I + GK Sbjct: 276 RPYKTMRF----HTEAIRAVRFHKGGLPLFADASDDGSLQI---FHGKVPNDQLENPTIV 328 Query: 81 --KTISGHK----LGISDVAWSSDSNLLVSASDDKTLKIW 114 K + GHK LG+ D+ W VSA D T ++W Sbjct: 329 PVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 31.2 bits (69), Expect = 0.70, Method: Compositional matrix adjust. Identities = 11/38 (28%), Positives = 20/38 (52%) Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 +GH V +P + +G D +VR+W++ TG+ Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGR 54 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 25/52 (48%), Gaps = 1/52 (1%) Query: 28 PTPVKPNYALKFTL-AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK 78 P +KP ++ T+ GH V SV P G LA+ D +++W G+ Sbjct: 3 PDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGR 54 Score = 27.7 bits (60), Expect = 7.1, Method: Compositional matrix adjust. Identities = 11/47 (23%), Positives = 25/47 (53%) Query: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK 126 + GH+ + VA L + DD T+++W++ +G+ + ++K Sbjct: 14 QTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVK 60 Score = 27.3 bits (59), Expect = 8.7, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 33/65 (50%), Gaps = 1/65 (1%) Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN-GK 227 H V +V + G + + DG R+W+ +G+ + ++ + + V+ V++ P Sbjct: 19 GHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDT 78 Query: 228 YILAA 232 +ILAA Sbjct: 79 FILAA 83 >5WLC-LN nrPDB Length = 776 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 50/110 (45%), Gaps = 11/110 (10%) Query: 93 VAWSSDSNLLVSASDDKTLKIW-----DVSSGKCLKTLK-----GHSNYVFCCNFNPQSN 142 +AW D + ++ D ++IW D + G+ L T+K S V+ + P+++ Sbjct: 193 LAWKKD-DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTD 251 Query: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 I SG S++ WD + ++ AH V + + D + + S+ D Sbjct: 252 QIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVD 301 Score = 37.0 bits (84), Expect = 0.012, Method: Compositional matrix adjust. Identities = 59/275 (21%), Positives = 113/275 (41%), Gaps = 45/275 (16%) Query: 50 SVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDK 109 SV + P + +AS + IK W ++ H + + +D+N + SA D+ Sbjct: 243 SVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDR 302 Query: 110 TLKIWDVSSGKCLKT----------LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 + + ++ K K L G+ C + ++ +VSG ++++ I + Sbjct: 303 KIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLT 362 Query: 160 --TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW----DTASGQ-----CLKT 208 + + +P V N++ L+VS S + +IW D+++ Q C T Sbjct: 363 SFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSWS-ESTVKIWTMGTDSSTEQNYKLVCKLT 421 Query: 209 LIDDDNPPVSFVKFSPNGKYILAAT-----------LDNTLKLWDYSKGKCLKTYTGHKN 257 L DD N +S SP+G+ ++ + N LK+ L+T T Sbjct: 422 LKDDQN--ISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTST---- 475 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 K F + K ++ ED+ V+I +L+++E Sbjct: 476 -KLVKF----IDNSKIVICSCEDD-VFIVDLESEE 504 Score = 27.3 bits (59), Expect = 8.6, Method: Compositional matrix adjust. Identities = 23/118 (19%), Positives = 43/118 (36%), Gaps = 10/118 (8%) Query: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGI------SDVAWS----SDSNLLVSASD 107 +++ +D I+IW A H + + S + WS ++ + S Sbjct: 199 DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDS 258 Query: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165 ++K WD ++ K H V C + +N + S D + + T K K Sbjct: 259 TGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQK 316 >4AV8-A nrPDB Length = 339 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 35/62 (56%), Gaps = 2/62 (3%) Query: 167 LPAHSDPVSAVHFNRDGSLIVSSSYDG-LCRIWDTASGQCLKTLIDD-DNPPVSFVKFSP 224 + AH++PV V NR G ++ + S DG L R++ T +G ++ D + +++SP Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 225 NG 226 +G Sbjct: 235 DG 236 >5A9Q-0 nrPDB Length = 380 Score = 37.0 bits (84), Expect = 0.013, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 7/99 (7%) Query: 111 LKIWDV----SSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKC-L 164 LKIWD + + +L G + C + +P Q +++ +G D + IWDV+ G + Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPV 254 Query: 165 KTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTAS 202 L AH + VHF+ + + + S DG WD ++ Sbjct: 255 SLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDAST 293 Score = 35.0 bits (79), Expect = 0.041, Method: Compositional matrix adjust. Identities = 34/176 (19%), Positives = 74/176 (42%), Gaps = 10/176 (5%) Query: 102 LVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 +V+ +D + ++ + ++T+ S+ + F ++ S + ++IWD + Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQ-LKIWDFRQ 202 Query: 161 G----KCLKTLPAHSDPVSAV--HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 + +L P+ V H N+ ++ + DG+ IWD G +L+ Sbjct: 203 QGNEPSQILSLTGDRVPLHCVDRHPNQQ-HVVATGGQDGMLSIWDVRQGTMPVSLLKAHE 261 Query: 215 PPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269 + V F P N +++ + D +L WD S K+ H+ + F + S++ Sbjct: 262 AEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSIS 317 >5M89-A nrPDB Length = 329 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 67/138 (48%), Gaps = 10/138 (7%) Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH 170 +K++D +G+ T + H+ V +P ++ S D+S +D++TG+ + + Sbjct: 114 VKVYD--AGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE--RVARGY 169 Query: 171 SD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 +D ++ F+ DG+L + + G ++ T + + ++ P+ + FS NG + Sbjct: 170 ADAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESF--PLGTPIQALAFSENG-FW 226 Query: 230 LAATLDNT--LKLWDYSK 245 AAT T + ++D K Sbjct: 227 FAATGKGTSSVTIFDLRK 244 >6CVZ-A nrPDB Length = 351 Score = 35.0 bits (79), Expect = 0.042, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 1/92 (1%) Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKG 127 +K+ + K + I H I +A+SS LL+SAS D T+K+ + + ++T Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 CC ++N I +G + S+ ++DV+ Sbjct: 116 GRPVWSCCWCLDEANYIYAGLANGSILVYDVR 147 >2VDU-B nrPDB Length = 450 Score = 35.0 bits (79), Expect = 0.052, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 13/100 (13%) Query: 80 EKTISGHKLGISDVAWSSDSN---LLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYV- 132 ++ I GH ++DV DS+ ++++ D+ +KI +C K L GH ++V Sbjct: 188 QEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYP--QCFIVDKWLFGHKHFVS 245 Query: 133 -FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS 171 CC + L++S D+ + WD KTGK L T +S Sbjct: 246 SICCG---KDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNS 282 >5A9Q-2 nrPDB Length = 326 Score = 34.3 bits (77), Expect = 0.071, Method: Compositional matrix adjust. Identities = 29/137 (21%), Positives = 63/137 (45%), Gaps = 14/137 (10%) Query: 150 DESVRIW--DVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCL 206 D +R++ D++ K L H+D ++ + F+ ++G I S S D CRIW+ Q Sbjct: 101 DMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTA 160 Query: 207 KTLIDDDNPPVSFVKFSPNGKY-ILAATLDNTLKLWDYSKGKCLKTYTGHK----NEKYC 261 ++ + P V + P + ++ A + T++ +D + + + + + +C Sbjct: 161 HFVL---HSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWC 217 Query: 262 IFANF---SVTGGKWIV 275 + F +V G W++ Sbjct: 218 LKNTFKVGAVAGNDWLI 234 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 29/143 (20%), Positives = 63/143 (44%), Gaps = 4/143 (2%) Query: 60 LASSSADKLIKIWGA--YDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDV 116 +S+AD I+++ + D K + GH I+ + + + + S SDD T +IW++ Sbjct: 95 FCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNL 154 Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176 G HS + C ++ ++ + ++R +D+ + + +L + P+ + Sbjct: 155 -EGVQTAHFVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMS 213 Query: 177 VHFNRDGSLIVSSSYDGLCRIWD 199 H+ + V + IWD Sbjct: 214 AHWCLKNTFKVGAVAGNDWLIWD 236 >5WLC-LL nrPDB Length = 643 Score = 32.0 bits (71), Expect = 0.42, Method: Compositional matrix adjust. Identities = 20/90 (22%), Positives = 39/90 (43%), Gaps = 2/90 (2%) Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 S+ + D++ K + T P H PVS + + I + D ++D SG L+ Sbjct: 169 SISLIDIEEKKVVMTFPGHVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTKCVLVA 228 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 + + + + S I T D +L+++ Sbjct: 229 ESD--IKELSHSGQADSIAVTTEDGSLEIF 256 Score = 28.1 bits (61), Expect = 5.7, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 44/105 (41%), Gaps = 4/105 (3%) Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 A S + LLV++ ++ + D+ K + T GH + V I D + Sbjct: 156 AGDSVAQLLVAS---HSISLIDIEEKKVVMTFPGHVSPVSTLQVITNEFFISGAEGDRFL 212 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 ++D+ +G L A SD H + S+ V++ DG I+ Sbjct: 213 NVYDIHSGMTKCVLVAESDIKELSHSGQADSIAVTTE-DGSLEIF 256 >5AMS-A nrPDB Length = 431 Score = 31.6 bits (70), Expect = 0.44, Method: Compositional matrix adjust. Identities = 25/127 (19%), Positives = 51/127 (40%), Gaps = 22/127 (17%) Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVK------------PNYALKFTLAG----- 43 M +E+ TE + P+ Q P ++ AL+ ++ Sbjct: 1 MEPQEEFITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTY 60 Query: 44 ---HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSD 98 HT +V ++ PN + + D L +W ++ KF T++G+ + +++S+ Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 99 SNLLVSA 105 LV+A Sbjct: 121 GGFLVTA 127 >6F1U-h nrPDB Length = 612 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 38/142 (26%), Positives = 62/142 (43%), Gaps = 25/142 (17%) Query: 79 FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCL----KTLKGHSNYVFC 134 F++ S H++ +S + WSS L+ AS + G L K K YVF Sbjct: 246 FDERWSKHRV-VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFH 304 Query: 135 CN----------FNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLP----AHSDPVSAVH 178 C F+P NL+V G++ + +WD ++ K ++ P AH+ PV V+ Sbjct: 305 CQSAVMSATFAKFHP--NLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVN 362 Query: 179 F--NRDGSLIVSSSYDGLCRIW 198 ++ ++S S DG W Sbjct: 363 VVGTQNAHNLISISTDGKICSW 384 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 24/106 (22%), Positives = 54/106 (50%), Gaps = 5/106 (4%) Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR--IW 198 S+L V+ SFD +V++W K K L + ++ V V ++ + + DG+ R +W Sbjct: 468 SHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALF-ACVDGMGRLDLW 526 Query: 199 DTASGQCLKT--LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 + + + T + + NP ++ V+++ +G+ I + + ++D Sbjct: 527 NLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYD 572 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 13/41 (31%), Positives = 26/41 (63%) Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139 S+L V++S D T+K+W + K L + + ++ YV+ ++P Sbjct: 468 SHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSP 508 >6N8P-A nrPDB Length = 979 Score = 31.6 bits (70), Expect = 0.55, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 20/29 (68%), Gaps = 1/29 (3%) Query: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 PQ +L+++G D +VR WD +G CL+ L Sbjct: 422 PQRDLLLTGHEDGTVRFWDA-SGVCLRLL 449 >2P9P-C nrPDB Length = 372 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 36/72 (50%), Gaps = 2/72 (2%) Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT--LKGHSNYVFCCNFNPQSNLIVSG 147 IS AW+ D + ++ + I++ S K ++ LK H+ V ++ P SN IV+ Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVTC 70 Query: 148 SFDESVRIWDVK 159 D + +W +K Sbjct: 71 GTDRNAYVWTLK 82 >5HX2-D nrPDB Length = 660 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 13/24 (54%), Positives = 17/24 (70%) Query: 164 LKTLPAHSDPVSAVHFNRDGSLIV 187 ++T+ +SDP V F RDGSLIV Sbjct: 618 VQTIELYSDPTDDVIFTRDGSLIV 641 >3F3P-A nrPDB Length = 351 Score = 31.2 bits (69), Expect = 0.70, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSS 97 +GH V V + G +A+ S+D+ IK++ + + + H I + W+S Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 98 DS--NLLVSASDDKTLKIWD 115 ++ SAS DKT+K+W+ Sbjct: 68 PEYGRIIASASYDKTVKLWE 87 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 50/252 (19%), Positives = 99/252 (39%), Gaps = 57/252 (22%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIW----DVSSGKCLKTLKGHSNYVFCCNF-N 138 SGH + DV + + + S D+ +K++ D S+ + + + H + + ++ + Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 139 PQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 P+ +I S S+D++V++W+ DP D ++ LC Sbjct: 68 PEYGRIIASASYDKTVKLWE-------------EDP--------DQEECSGRRWNKLC-- 104 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL--DNTLKLWDYSKGKCLKTYT-- 253 ++D + VKF+P + A L D L+L+D + L+++T Sbjct: 105 -----------TLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLT 153 Query: 254 -----------GHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQGH 300 H +C+ + + K VS E ++Y K + KL GH Sbjct: 154 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 213 Query: 301 TDVVISTACHPT 312 ++ S + P+ Sbjct: 214 KSLIRSISWAPS 225 >5TF2-A nrPDB Length = 407 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 14/50 (28%), Positives = 24/50 (48%) Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186 FN + L+ +G D VR+W V + + + AH + + DG L+ Sbjct: 180 FNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLV 229 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 15/65 (23%), Positives = 27/65 (41%), Gaps = 1/65 (1%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 V ++ D+ LL + D +++W V S + + K H + P L+ G D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGR-DLK 236 Query: 153 VRIWD 157 +W Sbjct: 237 ASVWQ 241 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 13/33 (39%), Positives = 18/33 (54%), Gaps = 1/33 (3%) Query: 171 SDPVS-AVHFNRDGSLIVSSSYDGLCRIWDTAS 202 SDP+ V FN D +L+ + DG R+W S Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPS 203 >6BN7-A nrPDB Length = 864 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 21/60 (35%), Positives = 36/60 (60%), Gaps = 7/60 (11%) Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 S V+F NGK L A++++T++L++++ K L+T H N I A + T G +I+ G Sbjct: 596 SMVEF--NGK--LLASINSTVRLYEWTTEKELRTECNHYNN---IMALYLKTKGDFILVG 648 >1FLG-A nrPDB Length = 582 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 42/92 (45%), Gaps = 4/92 (4%) Query: 110 TLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169 +L+ D SGK + K H ++ NL+ +G+ D + +D K+GK L Sbjct: 467 SLRAMDPVSGKVVWEHKEHLP-LWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQT 525 Query: 170 HSDPVS-AVHFNRDGS--LIVSSSYDGLCRIW 198 S VS + + +DG L V+ Y G +W Sbjct: 526 GSGIVSPPITWEQDGEQYLGVTVGYGGAVPLW 557 >5WLC-LS nrPDB Length = 594 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 12/103 (11%) Query: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSA---DKLIKIWGAYD 76 +++ T S PTPV L T +S+++FSP+G+ L +S D L + Sbjct: 497 NNAMTSSTPTPVA-------ALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSC 549 Query: 77 GKFEK-TISGHKLG-ISDVAWSSDSNLLVSASDDKTLKIWDVS 117 F SG LG ++ VA+S LL ++ +++W ++ Sbjct: 550 SVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 17/70 (24%), Positives = 33/70 (47%), Gaps = 7/70 (10%) Query: 137 FNPQSNLIVSGSFDESVRIW--DVKTGKCLKTLPAHSDPVSAVHF-----NRDGSLIVSS 189 F+P L+++G +D+++RI+ D KT + +L P+ F N++ I ++ Sbjct: 256 FHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTA 315 Query: 190 SYDGLCRIWD 199 WD Sbjct: 316 GRRRYMHSWD 325 >5JN2-A nrPDB Length = 525 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 31/74 (41%), Gaps = 2/74 (2%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 H N + + P++ L+ S S D ++RI D + D + ++ ++ Sbjct: 184 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYI--APEVL 241 Query: 188 SSSYDGLCRIWDTA 201 +YD C +W T Sbjct: 242 HGTYDEKCDVWSTG 255 >3MA6-A nrPDB Length = 298 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 31/74 (41%), Gaps = 2/74 (2%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 H N + + P++ L+ S S D ++RI D + D + ++ ++ Sbjct: 149 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYI--APEVL 206 Query: 188 SSSYDGLCRIWDTA 201 +YD C +W T Sbjct: 207 HGTYDEKCDVWSTG 220 >1MG2-A nrPDB Length = 390 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 4/81 (4%) Query: 58 EWLASSSADKLIKIWGAYDG-KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 EW +A + + + A G + K GH++ +V+ L ++ DKTL I D Sbjct: 307 EW-RHKTASRFVVVLDAKTGERLAKFEMGHEIDSINVSQDEKPLLYALSTGDKTLYIHDA 365 Query: 117 SSGKCLKTLK--GHSNYVFCC 135 SG+ L+++ GH V Sbjct: 366 ESGEELRSVNQLGHGPQVITT 386 >3EI3-B nrPDB Length = 383 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 33/167 (19%), Positives = 73/167 (43%), Gaps = 22/167 (13%) Query: 44 HTKAVSSVKFSPNGEWL-ASSSADKLIKIWGAYDGKFEKTISG---HKLGISDVAWS-SD 98 H V+ +F+P +WL A+SS D +K+W + K + + H+ ++ ++ +D Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTD 262 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC------CNFNPQSNLIVSGSFDE- 151 S L++ ++++ + H + F ++P +LIV+G + + Sbjct: 263 STKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDD 322 Query: 152 --------SVRIWDVKTGKCLKTL--PAHSDPVSAVHFNRDGSLIVS 188 ++ I+D +G + L P + +S F+ G ++ S Sbjct: 323 QLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLAS 369 >4TLV-A nrPDB Length = 591 Score = 28.5 bits (62), Expect = 3.8, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 6/40 (15%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 +N VF NP+S SF +++ WDV CLK L Sbjct: 295 QNNNVFLVEVNPKS------SFPQTIFFWDVYQRICLKDL 328 >1Y6Z-A nrPDB Length = 263 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 13/48 (27%), Positives = 26/48 (54%), Gaps = 4/48 (8%) Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 T A+ DP++ VHFN +G + S++ + I + + K + D++ Sbjct: 26 TFKAYDDPLAYVHFNVEGQI----SFNSILYIPGSLPWELSKNMFDEE 69 >5WLC-LH nrPDB Length = 896 Score = 28.1 bits (61), Expect = 5.9, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 27/48 (56%), Gaps = 2/48 (4%) Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--DTASGQCLKTL 209 ++ L H D V ++ F+ DGS ++S ++ + +W +T S Q L L Sbjct: 290 IRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRL 337 >2I3T-A nrPDB Length = 341 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 37/67 (55%), Gaps = 11/67 (16%) Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVISTACHPTENIIASAALEN------- 323 K++ + D ++ WNLQT++ ++ + + D V+ AC ++NI+ A ++ Sbjct: 264 KFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIAC--SDNILCLATSDDTFKTNAA 321 Query: 324 -DKTIKL 329 D+TI+L Sbjct: 322 IDQTIEL 328 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 11/37 (29%), Positives = 20/37 (54%) Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 PV+ ++FSP K++ A D + W+ K +K + Sbjct: 253 PVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNF 289 >3DWL-C nrPDB Length = 377 Score = 27.7 bits (60), Expect = 6.8, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 29/56 (51%) Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 +A++ L D + K +T H V C ++ P+SN IV+ S D + +++ + Sbjct: 30 TATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKR 85 >5L8S-A nrPDB Length = 604 Score = 27.3 bits (59), Expect = 8.4, Method: Compositional matrix adjust. Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 10/117 (8%) Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA---TLDNTLKLW 241 L+ +++ +G +W L + +F+KF P +Y+LA D +++ Sbjct: 30 LVFNANLNGKMNLWAMDLPDTYPYLFAHRDESCNFIKFDPENRYVLAGFDKDGDENYQIY 89 Query: 242 DYSKGKCL--KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY----IWNLQTKE 292 L TG +EKY F++ S G S++N + I NL+T E Sbjct: 90 AIPNEGGLPHPLITGDASEKYY-FSHLSADGKCVYYETSKENPSFLNTRIRNLETGE 145 >4UHN-A nrPDB Length = 468 Score = 27.3 bits (59), Expect = 8.4, Method: Compositional matrix adjust. Identities = 20/75 (26%), Positives = 33/75 (44%), Gaps = 13/75 (17%) Query: 167 LPAHSDPVSA-VHFNRDGSLIVSSS------------YDGLCRIWDTASGQCLKTLIDDD 213 L AH P SA +F++D +IV++ YD L +W +G K + D Sbjct: 37 LKAHWMPFSANRNFHKDPRIIVAAEGSWLVDDKGRRIYDSLSGLWTCGAGHSRKEIADAV 96 Query: 214 NPPVSFVKFSPNGKY 228 + + +SP +Y Sbjct: 97 AKQIGTLDYSPGFQY 111 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5M25-A nrPDB 437 e-123 2H9P-A nrPDB 414 e-116 5MZH-A nrPDB 296 1e-80 5NNZ-B nrPDB 293 7e-80 1VYH-C nrPDB 286 8e-78 6QX9-5O nrPDB 273 6e-74 6QX9-4B nrPDB 264 3e-71 6F3T-A nrPDB 262 1e-70 6Q8F-A nrPDB 251 3e-67 6ID0-T nrPDB 249 8e-67 5GAN-H nrPDB 244 5e-65 5FL8-q nrPDB 244 5e-65 3JB9-g nrPDB 242 1e-64 6QDV-o nrPDB 241 4e-64 5YZG-W nrPDB 241 4e-64 5NZU-C nrPDB 237 4e-63 6HQA-B nrPDB 236 9e-63 5Y88-O nrPDB 233 8e-62 6MZM-G nrPDB 231 2e-61 3MKQ-A nrPDB 229 1e-60 5G04-R nrPDB 229 2e-60 3JB9-L nrPDB 227 4e-60 4GGA-A nrPDB 224 3e-59 3DM0-A nrPDB 224 5e-59 4V6W-Ag nrPDB 223 7e-59 2YNP-A nrPDB 223 8e-59 5LCW-Q nrPDB 222 2e-58 5WLC-LO nrPDB 220 8e-58 5I2T-A nrPDB 217 7e-57 6G51-g nrPDB 216 1e-56 4V7E-Bg nrPDB 216 2e-56 5OPT-p nrPDB 215 3e-56 6BX3-A nrPDB 211 5e-55 6EOJ-D nrPDB 209 1e-54 4V8M-A7 nrPDB 209 2e-54 5UZ7-B nrPDB 207 4e-54 4N14-A nrPDB 207 4e-54 6N9G-C nrPDB 201 4e-52 5Z56-q nrPDB 200 6e-52 6HHQ-h nrPDB 200 8e-52 4LG8-A nrPDB 195 2e-50 3FM0-A nrPDB 194 3e-50 6J6H-n nrPDB 194 5e-50 5WYJ-BC nrPDB 194 5e-50 6CHG-A nrPDB 192 2e-49 5L9T-R nrPDB 190 6e-49 5FVM-C nrPDB 190 7e-49 5K1B-B nrPDB 186 1e-47 6EMK-B nrPDB 185 2e-47 3JAP-g nrPDB 185 3e-47 5XYI-g nrPDB 184 6e-47 6GMH-W nrPDB 184 6e-47 5WBU-D nrPDB 181 3e-46 4BTS-AR nrPDB 181 5e-46 2HES-X nrPDB 180 5e-46 5WYK-BB nrPDB 180 7e-46 5K0Y-T nrPDB 180 7e-46 5MWJ-A nrPDB 179 1e-45 5OQL-J nrPDB 178 3e-45 4AEZ-A nrPDB 176 1e-44 3ODT-A nrPDB 176 1e-44 4YCZ-A nrPDB 174 6e-44 5A31-R nrPDB 171 4e-43 5OV3-A nrPDB 171 4e-43 4U1E-I nrPDB 169 2e-42 4BH6-A nrPDB 168 2e-42 6E29-D nrPDB 166 1e-41 5OQL-X nrPDB 165 3e-41 4J0W-A nrPDB 164 7e-41 1NR0-A nrPDB 163 1e-40 5WJC-A nrPDB 160 7e-40 5OQL-d nrPDB 158 3e-39 4A11-B nrPDB 157 6e-39 3C9C-A nrPDB 155 2e-38 6ELZ-p nrPDB 154 4e-38 5Y1U-A nrPDB 154 5e-38 5WYJ-BE nrPDB 152 2e-37 3CFV-B nrPDB 152 2e-37 3JRO-A nrPDB 152 2e-37 5OQL-L nrPDB 151 4e-37 1PI6-A nrPDB 151 4e-37 4XYI-A nrPDB 147 7e-36 4L9O-A nrPDB 143 8e-35 5WLC-LJ nrPDB 143 1e-34 3ACP-A nrPDB 142 2e-34 5WLC-LU nrPDB 142 3e-34 6BX3-B nrPDB 141 4e-34 4BZK-B nrPDB 140 1e-33 3JRP-A nrPDB 139 2e-33 2AQ5-A nrPDB 135 2e-32 5N4A-A nrPDB 131 4e-31 5CXC-A nrPDB 128 3e-30 2PM9-A nrPDB 128 4e-30 5FA5-B nrPDB 127 5e-30 4G56-B nrPDB 127 8e-30 4XFV-A nrPDB 125 2e-29 4OWR-A nrPDB 125 3e-29 6CHG-D nrPDB 121 4e-28 5YZG-2 nrPDB 121 5e-28 6EM1-m nrPDB 113 1e-25 6C0F-s nrPDB 112 2e-25 6CB1-s nrPDB 112 2e-25 5WLC-LW nrPDB 109 2e-24 3JZG-A nrPDB 107 7e-24 4E5Z-B nrPDB 105 2e-23 5K19-A nrPDB 105 3e-23 5BJS-A nrPDB 103 1e-22 3JB9-S nrPDB 102 2e-22 3W15-A nrPDB 100 1e-21 5LTD-A nrPDB 84 7e-17 5MC6-j nrPDB 83 2e-16 Sequences not found previously or not previously below threshold: 5WLC-SG nrPDB 120 1e-27 4J0X-A nrPDB 119 2e-27 3BG0-A nrPDB 117 8e-27 5WLC-LN nrPDB 112 2e-25 5CXB-B nrPDB 107 7e-24 5M89-A nrPDB 104 7e-23 4PSX-B nrPDB 102 2e-22 5A9Q-7 nrPDB 101 5e-22 6F1U-h nrPDB 95 5e-20 3I2N-A nrPDB 93 2e-19 3F3P-A nrPDB 92 5e-19 5A9Q-2 nrPDB 91 5e-19 5A9Q-0 nrPDB 88 6e-18 3EI3-B nrPDB 87 7e-18 2P9P-C nrPDB 81 6e-16 5TF2-A nrPDB 79 4e-15 6IYY-A nrPDB 73 2e-13 5AMS-A nrPDB 72 5e-13 6CVZ-A nrPDB 70 1e-12 3DWL-C nrPDB 69 2e-12 3DW8-B nrPDB 68 5e-12 5AJA-A nrPDB 64 9e-11 5WLC-LS nrPDB 62 3e-10 6N8P-A nrPDB 62 4e-10 2I3T-A nrPDB 62 5e-10 5WLC-LL nrPDB 61 6e-10 5WLC-LH nrPDB 61 6e-10 5WLC-LV nrPDB 58 6e-09 2VDU-B nrPDB 57 1e-08 4FHN-A nrPDB 56 2e-08 4AV8-A nrPDB 55 5e-08 5K1H-B nrPDB 53 2e-07 5BPW-A nrPDB 47 1e-05 5BPT-A nrPDB 45 3e-05 4YHC-A nrPDB 43 1e-04 1C5K-A nrPDB 42 3e-04 6FYY-p nrPDB 42 4e-04 5GRS-A nrPDB 42 5e-04 4U1F-A nrPDB 39 0.002 2EEP-A nrPDB 39 0.003 4NOX-A nrPDB 38 0.005 4IMM-A nrPDB 38 0.006 3WJ9-A nrPDB 37 0.009 5CWW-B nrPDB 37 0.009 5L8S-A nrPDB 36 0.019 5SUM-A nrPDB 36 0.027 4GNB-A nrPDB 36 0.029 5WLC-LR nrPDB 35 0.038 5OLJ-A nrPDB 34 0.071 4HXF-B nrPDB 34 0.082 1MG2-A nrPDB 34 0.11 2QT9-A nrPDB 34 0.12 6DAM-A nrPDB 32 0.41 1FLG-A nrPDB 32 0.43 6IGR-A nrPDB 32 0.51 3MWP-A nrPDB 32 0.56 1SUS-A nrPDB 31 0.85 3R3L-A nrPDB 31 0.94 1Z68-A nrPDB 31 0.96 1BEV-1 nrPDB 31 0.97 5HAX-A nrPDB 31 0.98 5LJ5-t nrPDB 30 1.3 6FTI-5 nrPDB 30 1.3 4MF9-A nrPDB 30 1.4 4ZB4-A nrPDB 30 1.7 4IQB-A nrPDB 30 2.0 1K3I-A nrPDB 29 2.6 3ZKJ-A nrPDB 29 3.3 2PFZ-A nrPDB 29 3.4 6IGB-A nrPDB 28 5.1 4QI7-A nrPDB 28 7.4 >5M25-A nrPDB Length = 434 Score = 437 bits (1124), Expect = e-123, Method: Composition-based stats. Identities = 317/325 (97%), Positives = 317/325 (97%), Gaps = 2/325 (0%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 69 EA R Q SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI Sbjct: 112 IEAHREQI--GGSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 169 Query: 70 KIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 129 KIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS Sbjct: 170 KIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 229 Query: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS Sbjct: 230 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 289 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL Sbjct: 290 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 349 Query: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC Sbjct: 350 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 409 Query: 310 HPTENIIASAALENDKTIKLWKSDC 334 HPTENIIASAALENDKTIKLWKSDC Sbjct: 410 HPTENIIASAALENDKTIKLWKSDC 434 >2H9P-A nrPDB Length = 329 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 311/313 (99%), Positives = 311/313 (99%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK 81 TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK Sbjct: 17 QGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK 76 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS Sbjct: 77 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 136 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA Sbjct: 137 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 196 Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC Sbjct: 197 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 256 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL Sbjct: 257 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 316 Query: 322 ENDKTIKLWKSDC 334 ENDKTIKLWKSDC Sbjct: 317 ENDKTIKLWKSDC 329 >5MZH-A nrPDB Length = 452 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 102/295 (34%), Positives = 160/295 (54%), Gaps = 7/295 (2%) Query: 39 FTLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 FTL GH V ++ F+ P G+ + + S DK K+W AY G+ T+ GH+ I ++++ Sbjct: 130 FTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP 189 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 S ++ + S D T K+WDV +G+ TL GH + FN +LIV+GSFD R+WD Sbjct: 190 QSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWD 249 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 V+TG+C+ L H VS+ FN G+L+VS S D R+WD SG+CL ++ V Sbjct: 250 VRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCL-SVKQGHTDEV 308 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 V F G +++A+ D + +L+ G C T GH+ E + N G +++ Sbjct: 309 LDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFN---PQGTRLITA 365 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 S D +W+ T E +Q L+GHTD + S A + + I + + D T ++WK+ Sbjct: 366 SSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGS--KDNTCRIWKA 418 Score = 241 bits (616), Expect = 2e-64, Method: Composition-based stats. Identities = 90/257 (35%), Positives = 142/257 (55%), Gaps = 4/257 (1%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 L +TL GH + + F+P +A+ S D K+W G+ T++GH+ I + + Sbjct: 170 QLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGF 229 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 ++ +L+V+ S D ++WDV +G+C+ L GH V FN L+VSGS D + R+ Sbjct: 230 NTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRL 289 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 WDV++G+CL H+D V V F+ G+ +VS+S DG R++ T +G C TL+ Sbjct: 290 WDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLV-GHEG 348 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 +S V F+P G ++ A+ D T +LWD G+CL+ GH +E IF+ G +I+ Sbjct: 349 EISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDE---IFSCAFNYEGDFII 405 Query: 276 SGSEDNLVYIWNLQTKE 292 +GS+DN IW T Sbjct: 406 TGSKDNTCRIWKALTAS 422 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 74/256 (28%), Positives = 133/256 (51%), Gaps = 7/256 (2%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 K + H L +++ A++ + ++ S D+T K+W+ +G+ + TL+GH N V+ F Sbjct: 85 TLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAF 144 Query: 138 -NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196 NP + IV+GSFD++ ++WD TG+ TL H + + FN ++I + S D + Sbjct: 145 NNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAK 204 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 +WD +GQ TL + + F+ G I+ + D+ +LWD G+C+ +GH+ Sbjct: 205 LWDVETGQERATLA-GHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHR 263 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 E N++ G +VSGS D +W++++ + QGHTD V+ A + Sbjct: 264 GEVSSTQFNYA---GTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKM 320 Query: 317 ASAALENDKTIKLWKS 332 SA+ D + +L+ + Sbjct: 321 VSASA--DGSARLYHT 334 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 50/176 (28%), Positives = 86/176 (48%), Gaps = 7/176 (3%) Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 + K L AH P++ FN+ G ++ SYD C++W+T +G+ + TL + V Sbjct: 83 SFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTL-EGHKNVVYA 141 Query: 220 VKF-SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 + F +P G I+ + D T KLWD G+ T GH+ E C+ N I +GS Sbjct: 142 IAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFN---PQSTIIATGS 198 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 DN +W+++T + L GH ++S + ++I + + ++D +LW Sbjct: 199 MDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDS--RLWDVRT 252 >5NNZ-B nrPDB Length = 415 Score = 293 bits (750), Expect = 7e-80, Method: Composition-based stats. Identities = 99/293 (33%), Positives = 160/293 (54%), Gaps = 7/293 (2%) Query: 40 TLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 TL GH V ++ F+ P G+ +A+ S DK K+W GK T GH I ++++ Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 S L+ + S D T K+WD+ +G+ + TL+GHS + +FN + I++GSFD +V +WD Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 TG+ + L H +S+ FN D SLI++ S D C++WD +G+C+ TL + + Sbjct: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT-GHDDEIL 307 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 F GK I A+ D T +++ + KC+ GH+ E I N G +++GS Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 D IW+ QT + +Q L+GHTD + S A + NI+ + + D T ++W+ Sbjct: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIWR 415 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 96/336 (28%), Positives = 173/336 (51%), Gaps = 18/336 (5%) Query: 11 EAARAQPTPSSSATQSKPTPVKP-----------NYALKFTLAGHTKAVSSVKFSPNGEW 59 E +A+P ++S T+ ++ + L L H +++V + +G Sbjct: 47 EIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSC 106 Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSS 118 + S D+ K+W G+ T+ GH+ + +A+ + + + + S DKT K+W V + Sbjct: 107 FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET 166 Query: 119 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH 178 GKC T +GH+ + C +FNPQS L+ +GS D + ++WD++ G+ + TL HS + ++ Sbjct: 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLS 226 Query: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 FN G I++ S+D +WD +G+ + LI +S F+ + IL ++D T Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILI-GHCAEISSASFNWDCSLILTGSMDKTC 285 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 KLWD + GKC+ T TGH +E I + GK I + S D I++ T++ + KL+ Sbjct: 286 KLWDATNGKCVATLTGHDDE---ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLE 342 Query: 299 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 GH + + +P N + + + +DKT ++W + Sbjct: 343 GHEGEISKISFNPQGNHLLTGS--SDKTARIWDAQT 376 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 77/252 (30%), Positives = 135/252 (53%), Gaps = 4/252 (1%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 T GHT + + F+P +A+ S D K+W +G+ T+ GH I +++ Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 ++ + +++ S D T+ +WD +G+ + L GH + +FN +LI++GS D++ ++ Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 WD GKC+ TL H D + F+ G LI ++S DG RI+ A+ +C+ L + Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL-EGHEG 346 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 +S + F+P G ++L + D T ++WD G+CL+ GH +E IF+ G ++ Sbjct: 347 EISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDE---IFSCAFNYKGNIVI 403 Query: 276 SGSEDNLVYIWN 287 +GS+DN IW Sbjct: 404 TGSKDNTCRIWR 415 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 69/222 (31%), Positives = 119/222 (53%), Gaps = 2/222 (0%) Query: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79 S T +K ++ N +TL GH+ + S+ F+ +G+ + + S D + +W A G+ Sbjct: 195 GSMDTTAKLWDIQ-NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253 Query: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139 + GH IS +++ D +L+++ S DKT K+WD ++GKC+ TL GH + + F+ Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 LI + S D + RI+ T KC+ L H +S + FN G+ +++ S D RIWD Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373 Query: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 +GQCL+ L + + F+ G ++ + DNT ++W Sbjct: 374 AQTGQCLQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 >1VYH-C nrPDB Length = 410 Score = 286 bits (732), Expect = 8e-78, Method: Composition-based stats. Identities = 103/341 (30%), Positives = 172/341 (50%), Gaps = 26/341 (7%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK 70 EA + + P P K+ L+GH V+ V F P + S+S D IK Sbjct: 74 EAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIK 133 Query: 71 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 +W G FE+T+ GH + D+++ LL S S D T+K+WD +C++T+ GH + Sbjct: 134 VWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH 193 Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190 V + P + IVS S D+++++W+V+TG C+KT H + V V N+DG+LI S S Sbjct: 194 NVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253 Query: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN--------------------GKYIL 230 D R+W A+ +C K + + V + ++P G ++L Sbjct: 254 NDQTVRVWVVATKEC-KAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLL 312 Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 + + D T+K+WD S G CL T GH N + + +GGK+I+S ++D + +W+ + Sbjct: 313 SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH---SGGKFILSCADDKTLRVWDYKN 369 Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 K ++ L H V S H T + + ++ D+T+K+W+ Sbjct: 370 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSV--DQTVKVWE 408 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 72/230 (31%), Positives = 121/230 (52%), Gaps = 21/230 (9%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 + T+ GH VSSV PNG+ + S+S DK IK+W G KT +GH+ + V Sbjct: 182 FECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241 Query: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ-------------- 140 + D L+ S S+D+T+++W V++ +C L+ H + V C ++ P+ Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSET 301 Query: 141 ------SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194 ++SGS D+++++WDV TG CL TL H + V V F+ G I+S + D Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361 Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244 R+WD + +C+KTL + V+ + F Y++ ++D T+K+W+ Sbjct: 362 LRVWDYKNKRCMKTL-NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 5/130 (3%) Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264 K + PV+ V F P +++A+ D T+K+WDY G +T GH + I Sbjct: 99 PEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF 158 Query: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324 + S GK + S S D + +W+ Q E ++ + GH V S + P + I SA+ D Sbjct: 159 DHS---GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSAS--RD 213 Query: 325 KTIKLWKSDC 334 KTIK+W+ Sbjct: 214 KTIKMWEVQT 223 Score = 37.3 bits (85), Expect = 0.008, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 3/49 (6%) Query: 286 WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 W + E L GH V HP +++ SA+ D TIK+W + Sbjct: 94 WIPRPPEKYA-LSGHRSPVTRVIFHPVFSVMVSAS--EDATIKVWDYET 139 >6QX9-5O nrPDB Length = 357 Score = 273 bits (699), Expect = 6e-74, Method: Composition-based stats. Identities = 106/330 (32%), Positives = 173/330 (52%), Gaps = 16/330 (4%) Query: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71 A + Q TP + Q+ P A L+GH V KF PNG LAS+ D+LI + Sbjct: 34 AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92 Query: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 W Y D T+ GH + ++ +++D ++L SAS DKT+ +WD +G+ +K LKGH++ Sbjct: 93 WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152 Query: 131 YVFCCNFNPQSNLIV-SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 +V C + +V +GS D +V++WD++ ++T ++ V AV FN I+S Sbjct: 153 FVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISG 211 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS----K 245 D ++WD + T+ V+ + S G Y+L+ +DNT+++WD K Sbjct: 212 GIDNDIKVWDLRQNKLTYTM-RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270 Query: 246 GKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303 +C+K + G H EK + ++S G K I +GS D VY+W+ ++ I+ KL GH Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHAGS 329 Query: 304 VISTACHPTENIIASAALENDKTIKLWKSD 333 + A HP E II SA+ + +L+ + Sbjct: 330 INEVAFHPDEPIIISASSDK----RLYMGE 355 Score = 64.6 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 6/87 (6%) Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVIST 307 + +GH+ E YC + G + S D L+ +WN + L+GH+ V+ Sbjct: 59 IMLLSGHEGEVYCCKFH---PNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115 Query: 308 ACHPTENIIASAALENDKTIKLWKSDC 334 + +++ SA+ DKT+ +W S+ Sbjct: 116 HYNTDGSMLFSAS--TDKTVAVWDSET 140 >6QX9-4B nrPDB Length = 522 Score = 264 bits (675), Expect = 3e-71, Method: Composition-based stats. Identities = 82/342 (23%), Positives = 156/342 (45%), Gaps = 14/342 (4%) Query: 1 MATEEKKPETE-AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW 59 + K+ E + P + ++ + + + G + +S FSPN + Sbjct: 186 LPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKM 245 Query: 60 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL--------LVSASDDKTL 111 LA++ L K+W D T+ GH + + + S + L S + D ++ Sbjct: 246 LATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSV 305 Query: 112 KIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS 171 K+W + S + + ++GH+ V ++P + + +D S R+WD++ + + HS Sbjct: 306 KLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHS 365 Query: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA 231 V + F++DGSL + D R+WD +G+C+ ++ + + FSPNG +I Sbjct: 366 MGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-MFLEGHLKEIYGINFSPNGYHIAT 424 Query: 232 ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291 + DNT K+WD + +C+ T H+N + F G ++++G+ DN IW Sbjct: 425 GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGV--KFEPIHGNFLLTGAYDNTAKIWTHPGW 482 Query: 292 EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 ++ L GH V+ +IA+ + D+T KLW ++ Sbjct: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLWMAE 522 >6F3T-A nrPDB Length = 608 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 86/306 (28%), Positives = 146/306 (47%), Gaps = 17/306 (5%) Query: 27 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH 86 + P +T + +++V + + +A AD +++W K Sbjct: 260 RLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKL------- 312 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 V +SD +L+ SDD +I D + LK L GHS V+ +F+P N ++S Sbjct: 313 ----RSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLS 368 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 S D +VR+W ++T CL H+ PV F+ G VS +D + R+W T Q L Sbjct: 369 SSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPL 428 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 + + V+ +F PN Y+ + D T++LWD G C++ +TGHK I + Sbjct: 429 R-IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP---IHSLT 484 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326 G+++ +G+ D V +W++ +V +L+GHTD V S I+AS ++ D T Sbjct: 485 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSM--DNT 542 Query: 327 IKLWKS 332 ++LW + Sbjct: 543 VRLWDA 548 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 61/205 (29%), Positives = 101/205 (49%), Gaps = 1/205 (0%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH+ V FSP+ +L SSS D +++W GH + D +S Sbjct: 347 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 406 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 VS D+ ++W + L+ GH V C F+P SN + +GS D +VR+WDV Sbjct: 407 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 466 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G C++ H P+ ++ F+ +G + + + DG +WD G + L V + Sbjct: 467 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGHTDTVCSL 525 Query: 221 KFSPNGKYILAATLDNTLKLWDYSK 245 +FS +G+ + + ++DNT++LWD K Sbjct: 526 RFSRDGEILASGSMDNTVRLWDAIK 550 Score = 95.8 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 41/177 (23%), Positives = 62/177 (35%), Gaps = 17/177 (9%) Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D C T ++AV D SLI D R+W + Sbjct: 264 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKL----------- 312 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 VK + + I + D ++ D LK GH Y + +++S Sbjct: 313 -RSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFS---PDRNYLLS 368 Query: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 SED V +W+LQT + +GH V T P S +D+ +LW +D Sbjct: 369 SSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG--HDRVARLWATD 423 >6Q8F-A nrPDB Length = 514 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 91/322 (28%), Positives = 162/322 (50%), Gaps = 21/322 (6%) Query: 25 QSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS 84 + + P + + +KF G V +FSP+G++L + S D I++W GK K + Sbjct: 198 EEEKFPTQLSRHIKF---GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK 254 Query: 85 GH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCC 135 + + +S D+ +L + + D +K+W + SG+CL+ + HS V C Sbjct: 255 YQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCL 314 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195 +F+ S+ I+S SFD+++RI +K+GK LK HS V+ F +DG I+S+S DG Sbjct: 315 SFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTV 374 Query: 196 RIWDTASGQCLKTL-----IDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCL 249 +IW+ + +C T + V+ V P N ++ + NT+ + + +G+ + Sbjct: 375 KIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNM-QGQIV 433 Query: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309 ++++ K E G+WI ED ++Y ++ T ++ + L H VI A Sbjct: 434 RSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAH 493 Query: 310 HPTENIIASAALENDKTIKLWK 331 HP +N+IA+ + D +KLWK Sbjct: 494 HPHQNLIATYS--EDGLLKLWK 513 >6ID0-T nrPDB Length = 514 Score = 249 bits (637), Expect = 8e-67, Method: Composition-based stats. Identities = 87/333 (26%), Positives = 156/333 (46%), Gaps = 16/333 (4%) Query: 9 ETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKL 68 ET + + A P + L ++GH V + P +W + SAD+ Sbjct: 168 ETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRT 227 Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128 IKIW GK + +++GH + V S+ S L S +DK +K WD+ K ++ GH Sbjct: 228 IKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGH 287 Query: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 + V+ + +P +++V+ S D + RIWDV+T + TL H++ V+ V I++ Sbjct: 288 LSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIIT 347 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 S+D R+WD +G+ TL + V V P + + DN +K W + G Sbjct: 348 GSHDTTIRLWDLVAGKTRVTLT-NHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSF 405 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG--------H 300 ++ +GH I +V +VSG+++ +++W+ +T Q++ Sbjct: 406 IQNLSGH----NAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDS 461 Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSD 333 + + A +E+ + +A E DKTIK+++ D Sbjct: 462 ESGIFACAFDQSESRLLTA--EADKTIKVYRED 492 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 52/218 (23%), Positives = 94/218 (43%), Gaps = 9/218 (4%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 GH AV + P + L + S D +IW T+SGH ++ V + + Sbjct: 286 GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQI 345 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 ++ S D T+++WD+ +GK TL H V +P+ SGS D ++ W G Sbjct: 346 ITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGS 404 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID-------DDNP 215 ++ L H+ ++ + N DG ++VS + +G +WD +G + + D Sbjct: 405 FIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSES 463 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253 + F + +L A D T+K++ +T+ Sbjct: 464 GIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHP 501 >5GAN-H nrPDB Length = 465 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 89/340 (26%), Positives = 147/340 (43%), Gaps = 12/340 (3%) Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVK--PNYALKFTLAGHTKAVSSVKFSPNGE 58 + K+ + E R Q + S+ T ++ N L + TK +S+V S + Sbjct: 129 LERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVSLSTDDM 188 Query: 59 WLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVAWSSDSN-LLVSASDDKTLKIWDV 116 +A+ S +++ + + + H I + W DSN ++S ++D +K + Sbjct: 189 VVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQY 248 Query: 117 SSG----KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 S+ + L L GH + ++P I S S D + R+WD T + L H Sbjct: 249 SNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDK 308 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 V ++ F DGSL+ S D L +WD SG + TL + P+ V +SPNG + Sbjct: 309 GVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLA-GHSKPIYTVAWSPNGYQVATG 367 Query: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS-VTGGKWIVSGSEDNLVYIWNLQTK 291 D + +WD K + + FS GGK +VS DNL+ +++ T Sbjct: 368 GGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTW 427 Query: 292 EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + L GHTD +IS + + S D++IKLW Sbjct: 428 LKMGSLAGHTDKIISLDISNNSHFLVSGGW--DRSIKLWN 465 >5FL8-q nrPDB Length = 515 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 94/341 (27%), Positives = 157/341 (46%), Gaps = 54/341 (15%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-TISGHKLGISDVAWSS 97 TL GH V V +SP+GE +A+ S D I++W G+ + GH I+ ++W Sbjct: 180 HTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEP 239 Query: 98 -------DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 L S+S D T+KIWD S C T+ GH+N V C + Q L+ SGS D Sbjct: 240 IHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHD 298 Query: 151 ESVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDG-------------------------- 183 +VR+WD+ + G+C+ L +H+ V+ + + D Sbjct: 299 RTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALE 358 Query: 184 -------------SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 ++V++S D +W+ + V+ V FSP+G+YI+ Sbjct: 359 NYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIV 418 Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 +A+ DN++KLWD GK + T+ GH Y + + + + +VS S+D + +W+++T Sbjct: 419 SASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWS---SDCRLLVSCSKDTTLKVWDVRT 475 Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 +++ L GH D V + + S DK ++LW Sbjct: 476 RKLSVDLPGHKDEVYTVDWSVDGKRVCSGG--KDKMVRLWT 514 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 85/366 (23%), Positives = 148/366 (40%), Gaps = 55/366 (15%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD 76 + T VKP +AGH + F+P+ + + + D +IW Sbjct: 116 QITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDT 175 Query: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT-LKGHSNYVFCC 135 T+ GH + V+WS D ++ + S D T+++WD SG+CL L+GHS ++ Sbjct: 176 QTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSL 235 Query: 136 NFNP-------QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 ++ P + S S D +++IWD + C T+ H++ VS V + G L+ S Sbjct: 236 SWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYS 294 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN----------------------- 225 S+D R+WD S ++ V+ + S + Sbjct: 295 GSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQK 354 Query: 226 ----------------GKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFSV 268 + ++ A+ D T+ LW+ K + TGH +K FS Sbjct: 355 KALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGH--QKLVNHVAFS- 411 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328 G++IVS S DN + +W+ + + + +GH V A ++ S + D T+K Sbjct: 412 PDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCS--KDTTLK 469 Query: 329 LWKSDC 334 +W Sbjct: 470 VWDVRT 475 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 54/171 (31%), Positives = 87/171 (50%), Gaps = 3/171 (1%) Query: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKFEKTISGHK 87 P P A K L + K K + E + ++S D + +W K ++GH+ Sbjct: 345 KPSTPEEAQKKALENYEKI--CKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQ 402 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 ++ VA+S D +VSAS D ++K+WD GK + T +GH V+ ++ L+VS Sbjct: 403 KLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSC 462 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 S D ++++WDV+T K LP H D V V ++ DG + S D + R+W Sbjct: 463 SKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 >3JB9-g nrPDB Length = 558 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 88/301 (29%), Positives = 143/301 (47%), Gaps = 10/301 (3%) Query: 39 FTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWS 96 FT GHTK +S ++F P +G L S S D IKIW Y D +T GH I D+++S Sbjct: 260 FTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFS 319 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF--NPQS-NLIVSGSFDESV 153 D +S S DKT+K+WD GKCL C F +P N ++G+ D+ + Sbjct: 320 QDGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLAGTADKRI 378 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 +D+++ ++ H ++++ F +G V++S D R W+ + +K + D Sbjct: 379 LQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIA 438 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTG 270 + V PNGK I +LDN + ++ + K + G+ Y + FS Sbjct: 439 MHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFS-PD 497 Query: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 G+++ SG W+ +T +++ KL H+ V S A HP E + + D +IK W Sbjct: 498 GRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYW 557 Query: 331 K 331 Sbjct: 558 D 558 Score = 143 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 110/261 (42%), Gaps = 14/261 (5%) Query: 82 TISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDV-SSGKCLKTLKGHSNYVFCCNFNP 139 T GH GIS + + +LL+S S D +KIW+V L+T +GH+ + +F+ Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQ 320 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL---IVSSSYDGLCR 196 +S SFD+++++WD + GKCL + + V F D ++ + D Sbjct: 321 DGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLT-NCVKFQVDPDKPNEFLAGTADKRIL 379 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 +D S ++ D ++ + F NGK + + D++++ W+Y G + Sbjct: 380 QFDIRSPDIVQA-YDHHLGGINSITFLENGKRFVTTSDDSSMRFWEY--GTPVPIKFVAD 436 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK---EIVQKLQGHT--DVVISTACHP 311 + + GK I S DN +Y+++ K + +G++ + P Sbjct: 437 IAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSP 496 Query: 312 TENIIASAALENDKTIKLWKS 332 + S + WK+ Sbjct: 497 DGRFVFSGDSSGNACFWDWKT 517 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 100/272 (36%), Gaps = 16/272 (5%) Query: 27 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH 86 K V + +L T GH + + + FS +G S+S DK IK+W GK + Sbjct: 292 KIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS- 350 Query: 87 KLGISDVAWSSDSNL---LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 + V + D + ++ + DK + +D+ S ++ H + F Sbjct: 351 DRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKR 410 Query: 144 IVSGSFDESVRIWDVKTG---KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 V+ S D S+R W+ T K + + HS P V +G I S D ++ Sbjct: 411 FVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMP--RVALRPNGKSIACQSLDNCIYVYSA 468 Query: 201 --ASGQCLKTLIDDDNPPVSF--VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 Q K + + V FSP+G+++ + WD+ K + H Sbjct: 469 YEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHS 528 Query: 257 NEKYCIFANFSVTGGKWIVSGS-EDNLVYIWN 287 + F + + S D + W+ Sbjct: 529 GPVQSM--AFHPQETSKVATSSIVDGSIKYWD 558 Score = 71.6 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 26/92 (28%), Positives = 41/92 (44%), Gaps = 5/92 (5%) Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE-IVQKLQGHT 301 Y K + T+ GH C+ F G ++SGS DN + IW + +++ QGH Sbjct: 253 YIPKKHIFTWKGHTKGISCL--RFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHA 310 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWKSD 333 + + S + DKTIKLW ++ Sbjct: 311 RPIRDLSFSQDGRSFLSTSF--DKTIKLWDTE 340 >6QDV-o nrPDB Length = 513 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 149/328 (45%), Gaps = 15/328 (4%) Query: 15 AQPTPSSSATQSKPTPVK--PNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKI 71 P +S P K +GHTK VS+V+ P +G L S S D IK+ Sbjct: 190 HIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKL 249 Query: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 W Y + + +T GH + D+ +++ +SA+ D+ LK+WD +G+C+ Sbjct: 250 WEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV 309 Query: 131 YVFCCNFNPQ---SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 +C FNP NL V+G D+ + WD+++G+ ++ H V+ + F + V Sbjct: 310 P-YCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV 368 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247 S+S D R+W+ K + + + V SPNGK++ ++DN + ++ Sbjct: 369 STSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRF 428 Query: 248 CL---KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304 L K + GH Y +FS +++SG + + IW+ +T ++ + + H V Sbjct: 429 RLNKKKIFKGHMVAGYACQVDFS-PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVC 487 Query: 305 ISTACHPTENI-IASAALENDKTIKLWK 331 I HP E + + D IKLW Sbjct: 488 IGAVWHPHETSKVITCGW--DGLIKLWD 513 Score = 117 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 49/175 (28%), Positives = 81/175 (46%), Gaps = 6/175 (3%) Query: 161 GKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVS 218 K + H+ VSAV G L++S S D ++W+ +CL+T I + V Sbjct: 212 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFI-GHSKAVR 270 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 + F+ G L+A D LKLWD G+C+ +T K YC+ N V+G Sbjct: 271 DICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGM 329 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 D + W++++ EIVQ+ H V + S + +DK++++W+ D Sbjct: 330 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS--DDKSLRVWEWD 382 >5YZG-W nrPDB Length = 579 Score = 241 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 149/328 (45%), Gaps = 15/328 (4%) Query: 15 AQPTPSSSATQSKPTPVK--PNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKI 71 P +S P K +GHTK VS+V+ P +G L S S D IK+ Sbjct: 256 HIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKL 315 Query: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 W Y + + +T GH + D+ +++ +SA+ D+ LK+WD +G+C+ Sbjct: 316 WEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV 375 Query: 131 YVFCCNFNPQ---SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 +C FNP NL V+G D+ + WD+++G+ ++ H V+ + F + V Sbjct: 376 P-YCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV 434 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247 S+S D R+W+ K + + + V SPNGK++ ++DN + ++ Sbjct: 435 STSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRF 494 Query: 248 CL---KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304 L K + GH Y +FS +++SG + + IW+ +T ++ + + H V Sbjct: 495 RLNKKKIFKGHMVAGYACQVDFS-PDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVC 553 Query: 305 ISTACHPTENI-IASAALENDKTIKLWK 331 I HP E + + D IKLW Sbjct: 554 IGAVWHPHETSKVITCGW--DGLIKLWD 579 Score = 117 bits (293), Expect = 7e-27, Method: Composition-based stats. Identities = 49/175 (28%), Positives = 81/175 (46%), Gaps = 6/175 (3%) Query: 161 GKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVS 218 K + H+ VSAV G L++S S D ++W+ +CL+T I + V Sbjct: 278 KKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFI-GHSKAVR 336 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 + F+ G L+A D LKLWD G+C+ +T K YC+ N V+G Sbjct: 337 DICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGM 395 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 D + W++++ EIVQ+ H V + S + +DK++++W+ D Sbjct: 396 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS--DDKSLRVWEWD 448 >5NZU-C nrPDB Length = 905 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 129/301 (42%), Gaps = 8/301 (2%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 +K L + V SV P W+ +S + + +W KT L + + Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + N +V+ +DD +++++ ++ + + + HS+Y+ C +P I++ S D +++W Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 Query: 157 DV-KTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 D K C + H+ V + N D + S+S D ++W S TL + Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL-EGHE 185 Query: 215 PPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 V+ + + G Y+++ D +K+WDY C++T GH C + + Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELP--- 242 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 I++GSED V IW+ T + L + V A N +A E +KL + Sbjct: 243 IIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGRE 302 Query: 333 D 333 + Sbjct: 303 E 303 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 59/254 (23%), Positives = 117/254 (46%), Gaps = 4/254 (1%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 ++ ++ + V ++++ + ++ +W+ + +KT + V F Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65 Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 + N +V+G+ D +R+++ T + + AHSD + + + I++SS D L ++ Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKL 125 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 WD + + V + +P + +A+LD T+K+W T GH+ Sbjct: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 CI +S +++SG++D LV IW+ Q K VQ L+GH V + HP II Sbjct: 186 KGVNCIDY-YSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPII 244 Query: 317 ASAALENDKTIKLW 330 + + D T+++W Sbjct: 245 ITGS--EDGTVRIW 256 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 57/254 (22%), Positives = 108/254 (42%), Gaps = 8/254 (3%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 L T V + KF W+ + + D I+++ + H I +A Sbjct: 48 TLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAV 107 Query: 96 SSDSNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESV 153 ++++SDD +K+WD C + +GH++YV NP +N S S D ++ Sbjct: 108 HPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTI 167 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNR--DGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 ++W + + TL H V+ + + D ++S + D L +IWD + C++TL + Sbjct: 168 KVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTL-E 226 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 VS F P I+ + D T+++W S + T +C+ S+ G Sbjct: 227 GHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCV---ASLRGS 283 Query: 272 KWIVSGSEDNLVYI 285 + G ++ + + Sbjct: 284 NNVALGYDEGSIIV 297 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 66/253 (26%), Positives = 114/253 (45%), Gaps = 9/253 (3%) Query: 35 YALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 ++ GHT V + +P + AS+S D+ IK+W T+ GH+ G++ + Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191 Query: 94 AWSS--DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 + S D L+S +DD+ +KIWD + C++TL+GH+ V C +F+P+ +I++GS D Sbjct: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDG 251 Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 +VRIW T + TL + V V R + + +G + G+ + Sbjct: 252 TVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV---KLGREEPAMSM 308 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 D N + + K S + L A D +K + L E Y + G Sbjct: 309 DANGKIIWAKHSEVQQANLKAMGDTEIK---DGERLPLAVKDMGSCEIYPQTIQHNPNGR 365 Query: 272 KWIVSGSEDNLVY 284 +V G + ++Y Sbjct: 366 FVVVCGDGEYIIY 378 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 35/80 (43%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 N TL GH + VS F P + + S D ++IW + + E T++ + V Sbjct: 218 NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCV 277 Query: 94 AWSSDSNLLVSASDDKTLKI 113 A SN + D+ ++ + Sbjct: 278 ASLRGSNNVALGYDEGSIIV 297 >6HQA-B nrPDB Length = 722 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 116/238 (48%), Gaps = 4/238 (1%) Query: 15 AQPTPSSSATQSKPTPVKPNYAL----KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK 70 +P S ++ P + N + L GH+ AV V FSP+ +L S S DK ++ Sbjct: 419 IDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVR 478 Query: 71 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130 +W + GH + DV +S + +AS D+T ++W L+ GH N Sbjct: 479 LWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLN 538 Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190 V C F+P S + +GS D++ R+WD+ G+C++ HS ++ + + DG + S+ Sbjct: 539 DVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAG 598 Query: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 D + +WD ++G+ +K + + + FS G +++ DN++++WD K Sbjct: 599 EDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTN 656 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 129/277 (46%), Gaps = 24/277 (8%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE---------------- 80 +T ++ +KF+ + +AS D IK+W Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 81 -----KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135 + + GH + V +S D+ L+S S+DKT+++W + + CL + KGHS+ V+ Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDV 501 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195 F+P + + S D++ R+W L+ H + V V F+ + + + + S D Sbjct: 502 KFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTA 561 Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 R+WD A G+C++ + + ++ + SP+G+++ +A D+ + LWD S G+ +K GH Sbjct: 562 RMWDIARGECVRVFM-GHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGH 620 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 I++ G +VS DN V +W+++ Sbjct: 621 GR--SSIYSLAFSREGTVLVSTGADNSVRVWDVKKNT 655 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 126/276 (45%), Gaps = 30/276 (10%) Query: 79 FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK--------------- 123 T ++ + ++ DS ++ S D +K+W + G L+ Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSID-GSPLRSLLKNDPYNQQNNDG 440 Query: 124 -------TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176 L GHS V+ +F+P + ++S S D++VR+W + T CL + HS V Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWD 500 Query: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236 V F+ G ++S+D R+W L+ N V V+F PN Y+ + D Sbjct: 501 VKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLND-VDCVEFHPNSTYLFTGSSDK 559 Query: 237 TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 T ++WD ++G+C++ + GH C+ + G+W+ S ED++V +W++ T ++ Sbjct: 560 TARMWDIARGECVRVFMGHSGAINCLAVS---PDGRWLASAGEDSVVCLWDISTGRRIKA 616 Query: 297 LQGH-TDVVISTACHPTENIIASAALENDKTIKLWK 331 ++GH + S A ++ S D ++++W Sbjct: 617 MRGHGRSSIYSLAFSREGTVLVSTGA--DNSVRVWD 650 Score = 97.4 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 36/171 (21%), Positives = 69/171 (40%), Gaps = 27/171 (15%) Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 C+ T ++ ++ + FN D +++ S D ++W G L++L+ N P + Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSID-GSPLRSLLK--NDPYNQ--- 435 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 N + + GH Y + ++++S SED Sbjct: 436 -QNNDGVAVKGS---------------RRLVGHSGAVYGV---DFSPDNRYLISCSEDKT 476 Query: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 V +W+L T + +GH+ V P + A+A+ +D+T +LW D Sbjct: 477 VRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATAS--HDQTARLWSCD 525 Score = 55.0 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 39/108 (36%), Gaps = 26/108 (24%) Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ--------- 298 C+ T+ N+ C+ N + SG +D+ + +W++ + L+ Sbjct: 382 CMYTFHNTNNDLTCLKFN---DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNN 438 Query: 299 ------------GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 GH+ V P + S + DKT++LW D Sbjct: 439 DGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCS--EDKTVRLWSLDT 484 >5Y88-O nrPDB Length = 451 Score = 233 bits (594), Expect = 8e-62, Method: Composition-based stats. Identities = 85/335 (25%), Positives = 151/335 (45%), Gaps = 18/335 (5%) Query: 9 ETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADK 67 + E A S+ + L + GH V V P + EW + S D Sbjct: 103 QPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDT 162 Query: 68 LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127 +K+W GK + T++GH + + DVA S L S S+DKT+K WD+ + ++ G Sbjct: 163 TMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYG 222 Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 H + V + +P +LI + D +++WD++T + TL H P++ V +V Sbjct: 223 HLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVV 282 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247 SSS D R+WD +G+ +K L V P + +A D+ ++ W ++G Sbjct: 283 SSSTDATVRLWDVVAGKTMKVLT-HHKRSVRATALHPKEFSVASACTDD-IRSWGLAEGS 340 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK---------EIVQKLQ 298 L + ++EK I S+ + +G ++ ++ ++ ++ E+V L+ Sbjct: 341 LLTNF---ESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLE 397 Query: 299 GHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 G V+ + T + + E DK+IK+WK D Sbjct: 398 GERS-VLCSTFDKTGLRLITG--EADKSIKIWKQD 429 Score = 32.7 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 28/64 (43%), Gaps = 8/64 (12%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 + +L G ++V F G L + ADK IKIW + +++ G +A Sbjct: 390 REMVGSLEG-ERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPG-------LA 441 Query: 95 WSSD 98 W+ + Sbjct: 442 WNPN 445 >6MZM-G nrPDB Length = 800 Score = 231 bits (590), Expect = 2e-61, Method: Composition-based stats. Identities = 61/205 (29%), Positives = 101/205 (49%), Gaps = 1/205 (0%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH+ V FSP+ +L SSS D +++W GH + D +S Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 VS D+ ++W + L+ GH V C F+P SN + +GS D +VR+WDV Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658 Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G C++ H P+ ++ F+ +G + + + DG +WD G + L V + Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGHTDTVCSL 717 Query: 221 KFSPNGKYILAATLDNTLKLWDYSK 245 +FS +G+ + + ++DNT++LWD K Sbjct: 718 RFSRDGEILASGSMDNTVRLWDAIK 742 Score = 226 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 130/306 (42%), Gaps = 17/306 (5%) Query: 27 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH 86 + P +T + +++V + + +A AD +++ Sbjct: 452 RLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXX 511 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 KI L GHS V+ +F+P N ++S Sbjct: 512 XXXXXXXXXXXXXXXXXXXXXXXXXKI-----------LYGHSGPVYGASFSPDRNYLLS 560 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 S D +VR+W ++T CL H+ PV F+ G VS +D + R+W T Q L Sbjct: 561 SSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPL 620 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 + + V+ +F PN Y+ + D T++LWD G C++ +TGHK I + Sbjct: 621 R-IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGP---IHSLT 676 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326 G+++ +G+ D V +W++ +V +L+GHTD V S I+AS ++ D T Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSM--DNT 734 Query: 327 IKLWKS 332 ++LW + Sbjct: 735 VRLWDA 740 Score = 73.1 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 49/177 (27%), Gaps = 17/177 (9%) Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D C T ++AV D SLI D R+ Sbjct: 456 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXX 515 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 K GH Y + +++S Sbjct: 516 XXXXXXXXXXXXXX------------XXXXXXXKILYGHSGPVYGASFS---PDRNYLLS 560 Query: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 SED V +W+LQT + +GH V T P S +D+ +LW +D Sbjct: 561 SSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG--HDRVARLWATD 615 >3MKQ-A nrPDB Length = 814 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 129/289 (44%), Gaps = 9/289 (3%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 +K T + + V + F P W+ ++ ++IW ++I + + + Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFI 64 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + N ++ SDD +++++ ++G+ + + H +Y+ +P ++SGS D +V++W Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 157 DVKTGKCL-KTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 + + L +T H V V FN D S S D ++W TL Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQE 184 Query: 215 PPVSFVKFS--PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 V++V + P+ Y++ A+ D T+K+WDY C+ T GH + + Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSN---VSFAVFHPTLP 241 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE--NIIASA 319 I+SGSED + IWN T ++ + L + A HPT N IAS Sbjct: 242 IIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 113/256 (44%), Gaps = 3/256 (1%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 +KT S + + + +++ ++IW+ + +++++ V F Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKF 63 Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 + N I+ GS D +R+++ TG+ + AH D + ++ + ++S S D ++ Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 W+ + L+ + V V F+P + + LD T+K+W + T T + Sbjct: 124 WNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ 183 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 + + ++++ S+D + IW+ QTK V L+GH V HPT II Sbjct: 184 ERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPII 243 Query: 317 ASAALENDKTIKLWKS 332 S + D T+K+W S Sbjct: 244 ISGS--EDGTLKIWNS 257 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 75/359 (20%), Positives = 135/359 (37%), Gaps = 80/359 (22%) Query: 34 NYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGIS 91 N+AL+ T GH V V F+P + AS D+ +K+W T+ +G + G++ Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 92 DVAW--SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 V + D +++ASDD T+KIWD + C+ TL+GH + V F+P +I+SGS Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSE 248 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG--SLIVSSSYDGLC------------ 195 D +++IW+ T K KTL + + + G + I S +G Sbjct: 249 DGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLS 308 Query: 196 ------RIWDTASG---QCLKTLIDDDNPPVS--------------------FVKFSPNG 226 +W + T + N V + SPNG Sbjct: 309 LDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNG 368 Query: 227 KYILAATLDNTLKLW------DYSKGKCLKTYTGHKNEKYCI------------------ 262 +++ D ++ + + GKC G + Y + Sbjct: 369 RFVTVVG-DGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTS 427 Query: 263 FANFSVTGGKWIVSGS-----EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 ++ + + SG+ D VY ++ +V+++ + VI ++ Sbjct: 428 WSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI---WSDNGELV 483 >5G04-R nrPDB Length = 499 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 142/328 (43%), Gaps = 21/328 (6%) Query: 15 AQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74 + TP SS + P P+ L + ++ V +S +G LA + D + +W A Sbjct: 154 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSA 211 Query: 75 YDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132 G + + + G IS VAW + N L + +++WDV K L+ + HS V Sbjct: 212 SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV 271 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191 ++N S ++ SGS + DV+ + + TL HS V + + DG + S Sbjct: 272 GSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGN 329 Query: 192 DGLCRIWDTASGQ---CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSK 245 D L +W +A G+ V V + P +LA T D +++W+ Sbjct: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 389 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDV 303 G CL H +++ K ++SG N + IW T V +L+GHT Sbjct: 390 GACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 445 Query: 304 VISTACHPTENIIASAALENDKTIKLWK 331 V+S P +ASAA D+T++LW+ Sbjct: 446 VLSLTMSPDGATVASAAA--DETLRLWR 471 >3JB9-L nrPDB Length = 340 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 94/341 (27%), Positives = 168/341 (49%), Gaps = 22/341 (6%) Query: 5 EKKPETEAA-------RAQPTPSSSATQSKPTPVKPNYAL-KFTLAGHTKAVSSVKFSPN 56 +K+ E+E+A R + SS T+ + + + GHT V +F P+ Sbjct: 2 DKRKESESATNGHLVKRIRIQDSSLITEGSVLQRTSDLNVPNLQMFGHTAEVLVARFDPS 61 Query: 57 GEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115 G + AS D+ I +W + D K ++G K I+D+ WS DS ++ +S D L WD Sbjct: 62 GSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWD 121 Query: 116 VSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 SG+ ++ KGH+ V + + L+ S S D ++++WD ++ C+KT+ P+ Sbjct: 122 AVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEE-KYPL 180 Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 +AV + G+ + DG +IWD + C L ++ + S +G +L+ ++ Sbjct: 181 TAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVL-KGHKDIITSLAISKDGSSLLSNSM 239 Query: 235 DNTLKLWDY----SKGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 DNT++++D S + L+ + G H E + +S +++ +GS D VY+W+ Sbjct: 240 DNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-RNSRFVGAGSSDKNVYVWS- 297 Query: 289 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 T ++ L GH V HP ++II S + +D+TI L Sbjct: 298 ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCS--SDRTIFL 336 Score = 99.7 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 67/163 (41%), Gaps = 5/163 (3%) Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228 H+ V F+ GS S D +W+ +++ ++ +++S + + Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRV 107 Query: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 + ++ D L WD G+ ++ + GH + G + + S S+D + +W+ Sbjct: 108 VYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKV--GSELLTSVSDDCTMKVWDS 165 Query: 289 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 ++K+ ++ ++ + + A + + D IK+W Sbjct: 166 RSKDCIKTIE-EKYPLTAVAIAQQGTQVFIGGI--DGAIKIWD 205 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 27/126 (21%), Positives = 52/126 (41%), Gaps = 6/126 (4%) Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 V +F P+G Y + +D + LW+ +K Y K I Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGD--VKNYGVLNGCKGAITDLQWSRDS 105 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + + S D + W+ + + ++K +GH VV + + + + ++ +D T+K+W Sbjct: 106 RVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLT-SVSDDCTMKVWD 164 Query: 332 S---DC 334 S DC Sbjct: 165 SRSKDC 170 >4GGA-A nrPDB Length = 420 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 142/328 (43%), Gaps = 21/328 (6%) Query: 15 AQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74 + TP SS + P P+ L + ++ V +S +G LA + D + +W A Sbjct: 75 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSA 132 Query: 75 YDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132 G + + + G IS VAW + N L + +++WDV K L+ + HS V Sbjct: 133 SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV 192 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191 ++N S ++ SGS + DV+ + + TL HS V + + DG + S Sbjct: 193 GSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGN 250 Query: 192 DGLCRIWDTASGQ---CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSK 245 D L +W +A G+ V V + P +LA T D +++W+ Sbjct: 251 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 310 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDV 303 G CL H +++ K ++SG N + IW T V +L+GHT Sbjct: 311 GACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 366 Query: 304 VISTACHPTENIIASAALENDKTIKLWK 331 V+S P +ASAA D+T++LW+ Sbjct: 367 VLSLTMSPDGATVASAAA--DETLRLWR 392 >3DM0-A nrPDB Length = 694 Score = 224 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 140/299 (46%), Gaps = 32/299 (10%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIK 70 A+R + T+ + L GH+ V V S +G++ S S D ++ Sbjct: 400 SASRDKSIILWKLTKDDKAYGVA----QRRLTGHSHFVEDVVLSSDGQFALSGSWDGELR 455 Query: 71 IWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL----K 126 +W G + GH + VA+S D+ +VSAS D+T+K+W+ G+C T+ + Sbjct: 456 LWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGGE 514 Query: 127 GHSNYVFCCNFNPQ--SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184 GH ++V C F+P IVS S+D++V++W++ K TL H+ VS V + DGS Sbjct: 515 GHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGS 574 Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244 L S DG+ +WD A G+ L +L + N + + FSPN +Y L A ++ +K+WD Sbjct: 575 LCASGGKDGVVLLWDLAEGKKLYSL--EANSVIHALCFSPN-RYWLCAATEHGIKIWDLE 631 Query: 245 KGKCLKTYTGH-----------------KNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 ++ + YC N+S G + SG D ++ +W Sbjct: 632 SKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGST-LFSGYTDGVIRVW 689 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 84/325 (25%), Positives = 147/325 (45%), Gaps = 40/325 (12%) Query: 37 LKFTLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90 LK T+ HT V+++ N + + S+S DK I +W G ++ ++GH + Sbjct: 374 LKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFV 433 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 DV SSD +S S D L++WD+++G + GH+ V F+ + IVS S D Sbjct: 434 EDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRD 493 Query: 151 ESVRIWDVKTGKCLKTL----PAHSDPVSAVHFNRDG--SLIVSSSYDGLCRIWDTASGQ 204 ++++W+ G+C T+ H D VS V F+ + IVS+S+D ++W+ ++ + Sbjct: 494 RTIKLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCK 552 Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264 L++ + VS V SP+G + D + LWD ++GK L + + I A Sbjct: 553 -LRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEAN----SVIHA 607 Query: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ---------------GHTDV----VI 305 W+ + +E + IW+L++K IV+ L+ T Sbjct: 608 LCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCT 666 Query: 306 STACHPTENIIASAALENDKTIKLW 330 S + + S D I++W Sbjct: 667 SLNWSADGSTLFSG--YTDGVIRVW 689 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 73/266 (27%), Positives = 128/266 (48%), Gaps = 19/266 (7%) Query: 79 FEKTISGHKLGISDVAWSSDS-NLLVSASDDKTLKIW-----DVSSGKCLKTLKGHSNYV 132 + T+ H ++ +A D+ +++VSAS DK++ +W D + G + L GHS++V Sbjct: 374 LKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFV 433 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 + +SGS+D +R+WD+ G + H+ V +V F+ D IVS+S D Sbjct: 434 EDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRD 493 Query: 193 GLCRIWDTASGQCLKTLIDD---DNPPVSFVKFSPN--GKYILAATLDNTLKLWDYSKGK 247 ++W+T G+C T+ + VS V+FSPN I++A+ D T+K+W+ S K Sbjct: 494 RTIKLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCK 552 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307 T GH + + G SG +D +V +W+L + + L+ V+ + Sbjct: 553 LRSTLAGHTGYVSTVAVS---PDGSLCASGGKDGVVLLWDLAEGKKLYSLEA-NSVIHAL 608 Query: 308 ACHPTENIIASAALENDKTIKLWKSD 333 P + +A IK+W + Sbjct: 609 CFSPNRYWLCAATEHG---IKIWDLE 631 Score = 31.9 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGA 74 +S+ +S +G L S D +I++WG Sbjct: 666 TSLNWSADGSTLFSGYTDGVIRVWGI 691 >4V6W-Ag nrPDB Length = 318 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 87/303 (28%), Positives = 153/303 (50%), Gaps = 23/303 (7%) Query: 1 MATEEKKPET--EAARAQPTPSSSATQSKPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNG 57 +AT K P+T A+R + T+ + T NY + L GH+ +S V S +G Sbjct: 21 IATNPKDPDTIISASRDKTLIVWKLTRDEDT----NYGYPQKRLYGHSHFISDVVLSSDG 76 Query: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117 + S S D+ +++W GK + GH + VA+S+D+ +VS S DKT+K+W+ Sbjct: 77 NYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL 136 Query: 118 SGKCLKTLK--GHSNYVFCCNFNPQ--SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 173 +C T++ GH+++V C F+P + +IVS +D +V++W++ K H+ Sbjct: 137 -AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGY 195 Query: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT 233 ++ V + DGSL S D +WD G+ L TL + N ++ + FSPN +Y L Sbjct: 196 LNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTL--EHNDIINALCFSPN-RYWLCVA 252 Query: 234 LDNTLKLWDYSKGKCLKTY-------TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 ++K+WD + K ++ T ++ C+ +S T G+ + +G DN + +W Sbjct: 253 YGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWS-TDGQTLFAGYSDNTIRVW 311 Query: 287 NLQ 289 + Sbjct: 312 QVS 314 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 87/315 (27%), Positives = 148/315 (46%), Gaps = 27/315 (8%) Query: 36 ALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD------GKFEKTISGHKL 88 L+ TL GH V+ + +P + + + S+S DK + +W G +K + GH Sbjct: 6 QLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSH 65 Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 ISDV SSD N +S S D+TL++WD+++GK + +GH+ V F+ + IVSGS Sbjct: 66 FISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGS 125 Query: 149 FDESVRIWD-VKTGKCLKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLCRIWDTASGQC 205 D+++++W+ + K H+D VS V F+ + +IVS +D ++W+ A+ + Sbjct: 126 RDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK- 184 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 LK N ++ V SP+G + D+ LWD + GK L T I A Sbjct: 185 LKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE----HNDIINAL 240 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---------QGHTDVVISTACHPTENII 316 W+ + IW+L K+ V++L + +S A + Sbjct: 241 CFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTL 299 Query: 317 ASAALENDKTIKLWK 331 + +D TI++W+ Sbjct: 300 FAG--YSDNTIRVWQ 312 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 73/270 (27%), Positives = 127/270 (47%), Gaps = 16/270 (5%) Query: 74 AYDGKFEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIW------DVSSGKCLKTLK 126 + + T+ GH ++ +A + D + ++SAS DKTL +W D + G K L Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 127 GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186 GHS+++ + N +SGS+D+++R+WD+ GK + H+ V +V F+ D I Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQI 121 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK--YILAATLDNTLKLWDYS 244 VS S D ++W+T + D VS V+FSPN I++ D T+K+W+ + Sbjct: 122 VSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLA 181 Query: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304 K + GH + + G SG +D+ +W+L + + L+ H D++ Sbjct: 182 NCKLKNNHHGHNGYLNTVTVS---PDGSLCTSGGKDSKALLWDLNDGKNLYTLE-HNDII 237 Query: 305 ISTACHPTENIIASAALENDKTIKLWKSDC 334 + P + A +IK+W C Sbjct: 238 NALCFSPNRYWLCVAYGP---SIKIWDLAC 264 >2YNP-A nrPDB Length = 604 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 129/289 (44%), Gaps = 9/289 (3%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 +K T + + V + F P W+ ++ +++W ++I + + + Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFI 64 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 + N ++ SDD +++++ ++G+ + + H +Y+ +P ++SGS D +V++W Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 157 DVKTGKCL-KTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 + + L +T H V V FN D S S D ++W TL Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQE 184 Query: 215 PPVSFVKFS--PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 V++V + P+ Y++ A+ D T+K+WDY C+ T GH + + Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSN---VSFAVFHPTLP 241 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE--NIIASA 319 I+SGSED + IWN T ++ + L + A HPT N IAS Sbjct: 242 IIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASG 290 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 56/256 (21%), Positives = 113/256 (44%), Gaps = 3/256 (1%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 +KT S + + + +++ +++W+ + +++++ V F Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKF 63 Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197 + N I+ GS D +R+++ TG+ + AH D + ++ + ++S S D ++ Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 W+ + L+ + V V F+P + + LD T+K+W + T T + Sbjct: 124 WNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQ 183 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 + + ++++ S+D + IW+ QTK V L+GH V HPT II Sbjct: 184 ERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPII 243 Query: 317 ASAALENDKTIKLWKS 332 S + D T+K+W S Sbjct: 244 ISGS--EDGTLKIWNS 257 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 75/359 (20%), Positives = 135/359 (37%), Gaps = 80/359 (22%) Query: 34 NYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGIS 91 N+AL+ T GH V V F+P + AS D+ +K+W T+ +G + G++ Sbjct: 129 NWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 92 DVAW--SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 V + D +++ASDD T+KIWD + C+ TL+GH + V F+P +I+SGS Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSE 248 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG--SLIVSSSYDGLC------------ 195 D +++IW+ T K KTL + + + G + I S +G Sbjct: 249 DGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLS 308 Query: 196 ------RIWDTASG---QCLKTLIDDDNPPVS--------------------FVKFSPNG 226 +W + T + N V + SPNG Sbjct: 309 LDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNG 368 Query: 227 KYILAATLDNTLKLW------DYSKGKCLKTYTGHKNEKYCI------------------ 262 +++ D ++ + + GKC G + Y + Sbjct: 369 RFVTVVG-DGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTS 427 Query: 263 FANFSVTGGKWIVSGS-----EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 ++ + + SG+ D VY ++ +V+++ + VI ++ Sbjct: 428 WSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI---WSDNGELV 483 >5LCW-Q nrPDB Length = 374 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 142/328 (43%), Gaps = 21/328 (6%) Query: 15 AQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74 + TP SS + P P+ L + ++ V +S +G LA + D + +W A Sbjct: 29 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSA 86 Query: 75 YDGKFEKTISGHKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132 G + + + G IS VAW + N L + +++WDV K L+ + HS V Sbjct: 87 SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARV 146 Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191 ++N S ++ SGS + DV+ + + TL HS V + + DG + S Sbjct: 147 GSLSWN--SYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGN 204 Query: 192 DGLCRIWDTASGQ---CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSK 245 D L +W +A G+ V V + P +LA T D +++W+ Sbjct: 205 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCS 264 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDV 303 G CL H +++ K ++SG N + IW T V +L+GHT Sbjct: 265 GACLSAVDAHSQVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 320 Query: 304 VISTACHPTENIIASAALENDKTIKLWK 331 V+S P +ASAA D+T++LW+ Sbjct: 321 VLSLTMSPDGATVASAAA--DETLRLWR 346 >5WLC-LO nrPDB Length = 923 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 76/384 (19%), Positives = 154/384 (40%), Gaps = 79/384 (20%) Query: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80 + AGH + ++S+ +S + ++ ++S D KIW + Sbjct: 122 WKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKN 181 Query: 81 ---KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------------------ 119 T +GH+ + +S D + + S D + +W+ + Sbjct: 182 LAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEV 241 Query: 120 ---------KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL--- 167 + V C F+P + L+ G R++D+ ++ L Sbjct: 242 DISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMG 301 Query: 168 ----------------------------------------PAHSDPVSAVHFNRDGSLIV 187 H D +++ ++ DGS +V Sbjct: 302 QNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVV 361 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247 ++S DG ++WD SG CL T ++ V+ V+F+ G+ + +++LD T++ WD + + Sbjct: 362 TASEDGKIKVWDITSGFCLATF-EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYR 420 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQKLQGHTDVVIS 306 +T+TG + ++ A G+ + +GS DN +++W++QT +++ L GH V Sbjct: 421 NFRTFTGTERIQFNCLAVD--PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSC 478 Query: 307 TACHPTENIIASAALENDKTIKLW 330 + +++ASA+ DKTI++W Sbjct: 479 LSFSQENSVLASASW--DKTIRIW 500 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 5/292 (1%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 K + V V F P LA +++ D + +S + ++ V+ + Sbjct: 253 KHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQ 312 Query: 98 DSNLLVSASDD-KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 L S L +++ S + +GH + ++P + +V+ S D +++W Sbjct: 313 TGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 372 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+ +G CL T H+ V+AV F + G ++ SSS DG R WD + +T + Sbjct: 373 DITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQ 432 Query: 217 VSFVKFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 + + P+G+ + A +LDN + +W G+ L +GH+ C+ + + Sbjct: 433 FNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQE---NSVLA 489 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 S S D + IW++ + + V++ + P +A + L+ +I Sbjct: 490 SASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISI 541 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 133/286 (46%), Gaps = 12/286 (4%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD-KLIKIWGAYDGKFEKTISGHKLGIS 91 P++ L L+ V++V + GEWLA S+ + ++ + GH + Sbjct: 290 PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTN 349 Query: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 +A+S D + +V+AS+D +K+WD++SG CL T + H++ V F + ++ S S D Sbjct: 350 SLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDG 409 Query: 152 SVRIWDVKTGKCLKTLPAHSDPV--SAVHFNRDGSLIVSSSYDGL-CRIWDTASGQCLKT 208 +VR WD+ + +T ++ + + + + G ++ + S D +W +GQ L Sbjct: 410 TVRAWDLIRYRNFRTFTG-TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDA 468 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFS 267 L PVS + FS + +A+ D T+++W + + + ++ + + + A Sbjct: 469 LS-GHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD----VLALSM 523 Query: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 313 GK + + + I+N++ + V + D +IS + Sbjct: 524 RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKD-IISGRFNQDR 568 Score = 152 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 129/329 (39%), Gaps = 47/329 (14%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS---------GHKLGISDV 93 + S+VKFSP+G A +S + ++IW D ++ + GH I+ + Sbjct: 94 NFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSL 152 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 WS DS +++ S D + KIW V S + T GH +YV F+ I + S D Sbjct: 153 TWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKD 212 Query: 151 ESVRIW-----------------------DVKTGKCLKT----LPAHSDPVSAVHFNRDG 183 +V +W D+ T A+ V V F+ Sbjct: 213 GAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT 272 Query: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD-NTLKLWD 242 L+ G R++D ++ L N PV+ V + G+++ + L +++ Sbjct: 273 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQN-PVNTVSVNQTGEWLAFGSSKLGQLLVYE 331 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 + + GH + + G +V+ SED + +W++ + + + HT Sbjct: 332 WQSESYILKQQGHFDSTNSL---AYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTS 388 Query: 303 VVISTACHPTENIIASAALENDKTIKLWK 331 V + ++ S++L D T++ W Sbjct: 389 SVTAVQFAKRGQVMFSSSL--DGTVRAWD 415 Score = 143 bits (361), Expect = 9e-35, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 118/334 (35%), Gaps = 47/334 (14%) Query: 38 KFTLA-GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 FT H K ++++ + G L S D + + K S V +S Sbjct: 47 SFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFN-FKEKCSAVKFS 105 Query: 97 SDSNLLVSASDDKTLKIW---DVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSG 147 D L AS + L+IW DV+ + + GH + ++ S I++ Sbjct: 106 PDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT 164 Query: 148 SFDESVRIWDVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204 S D S +IW V + + T H D V F+ D I + S DG +W+ Sbjct: 165 SKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRP 224 Query: 205 CL--------------------------KTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 K + V V F P + + Sbjct: 225 SDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEF 284 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED-NLVYIWNLQTKEIVQKL 297 +L+D ++ + +N + N + G+W+ GS + ++ Q++ + K Sbjct: 285 RLYDLPDFTLIQQLSMGQNPVNTVSVNQT---GEWLAFGSSKLGQLLVYEWQSESYILKQ 341 Query: 298 QGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 QGH D S A P + + +A+ D IK+W Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTAS--EDGKIKVWD 373 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 136/329 (41%), Gaps = 49/329 (14%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAW 95 T HT +V++V+F+ G+ + SSS D ++ W + +T +G ++ + +A Sbjct: 379 CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV 438 Query: 96 SSDSNLLVSASDDKT-LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 ++ + S D + +W V +G+ L L GH V C +F+ +++++ S S+D+++R Sbjct: 439 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIR 498 Query: 155 IWDV-KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--------------- 198 IW + + ++ + +SD V A+ DG + S+ G I+ Sbjct: 499 IWSIFGRSQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRK 557 Query: 199 DTASGQCLKTLIDDDNPPV----SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254 D SG+ + N + + +S +G I+A +N++ L+D LK + Sbjct: 558 DIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIV 617 Query: 255 HKNEKYCIFANFSVTGGKWIVSGSED--------------------NLVYIWNLQTKEIV 294 +N F + K +GS D +L T+++ Sbjct: 618 SRNMALNGTLEF-LNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMR 676 Query: 295 QKLQGHTDVVISTACHPTENIIASAALEN 323 V S PT N A+A+ E Sbjct: 677 -----PEVRVTSVQFSPTANAFAAASTEG 700 Score = 91.6 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 46/265 (17%), Positives = 93/265 (35%), Gaps = 44/265 (16%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 + +S D L+S ++ + ++D+ + K H + + N Q L++S D Sbjct: 20 ITFSDDGKQLLSPVGNR-VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 78 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW---DTASGQCLKTL 209 + + K L + SAV F+ DG L +S +IW D + Sbjct: 79 AILVNFKARNVLHHFN-FKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPF 136 Query: 210 IDD-----DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYC 261 + ++ + +S + ++IL + D + K+W + T+ GH++ Sbjct: 137 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDY--- 193 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNL-------------------------QTKEIVQK 296 + F + I + S+D V++W + I +K Sbjct: 194 VMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 253 Query: 297 --LQGHTDVVISTACHPTENIIASA 319 + V HP ++A Sbjct: 254 HFFYANQAKVKCVTFHPATRLLAVG 278 Score = 28.4 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 18/30 (60%), Gaps = 1/30 (3%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 V+SV+FSP A++S + L+ I+ D Sbjct: 681 VTSVQFSPTANAFAAASTEGLL-IYSTNDT 709 >5I2T-A nrPDB Length = 742 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 76/384 (19%), Positives = 154/384 (40%), Gaps = 79/384 (20%) Query: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80 + AGH + ++S+ +S + ++ ++S D KIW + Sbjct: 147 WKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKN 206 Query: 81 ---KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------------------ 119 T +GH+ + +S D + + S D + +W+ + Sbjct: 207 LAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEV 266 Query: 120 ---------KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL--- 167 + V C F+P + L+ G R++D+ ++ L Sbjct: 267 DISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMG 326 Query: 168 ----------------------------------------PAHSDPVSAVHFNRDGSLIV 187 H D +++ ++ DGS +V Sbjct: 327 QNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVV 386 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247 ++S DG ++WD SG CL T ++ V+ V+F+ G+ + +++LD T++ WD + + Sbjct: 387 TASEDGKIKVWDITSGFCLATF-EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYR 445 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQKLQGHTDVVIS 306 +T+TG + ++ A G+ + +GS DN +++W++QT +++ L GH V Sbjct: 446 NFRTFTGTERIQFNCLAVD--PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSC 503 Query: 307 TACHPTENIIASAALENDKTIKLW 330 + +++ASA+ DKTI++W Sbjct: 504 LSFSQENSVLASASW--DKTIRIW 525 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 5/292 (1%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 K + V V F P LA +++ D + +S + ++ V+ + Sbjct: 278 KHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQ 337 Query: 98 DSNLLVSASDD-KTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 L S L +++ S + +GH + ++P + +V+ S D +++W Sbjct: 338 TGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 397 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+ +G CL T H+ V+AV F + G ++ SSS DG R WD + +T + Sbjct: 398 DITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQ 457 Query: 217 VSFVKFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 + + P+G+ + A +LDN + +W G+ L +GH+ C+ + + Sbjct: 458 FNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQE---NSVLA 514 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 S S D + IW++ + + V++ + P +A + L+ +I Sbjct: 515 SASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISI 566 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 133/286 (46%), Gaps = 12/286 (4%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD-KLIKIWGAYDGKFEKTISGHKLGIS 91 P++ L L+ V++V + GEWLA S+ + ++ + GH + Sbjct: 315 PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTN 374 Query: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 +A+S D + +V+AS+D +K+WD++SG CL T + H++ V F + ++ S S D Sbjct: 375 SLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDG 434 Query: 152 SVRIWDVKTGKCLKTLPAHSDPV--SAVHFNRDGSLIVSSSYDGL-CRIWDTASGQCLKT 208 +VR WD+ + +T ++ + + + + G ++ + S D +W +GQ L Sbjct: 435 TVRAWDLIRYRNFRTFTG-TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDA 493 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFS 267 L PVS + FS + +A+ D T+++W + + + ++ + + + A Sbjct: 494 LS-GHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD----VLALSM 548 Query: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 313 GK + + + I+N++ + V + D +IS + Sbjct: 549 RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKD-IISGRFNQDR 593 Score = 150 bits (379), Expect = 7e-37, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 129/329 (39%), Gaps = 47/329 (14%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS---------GHKLGISDV 93 + S+VKFSP+G A +S + ++IW D ++ + GH I+ + Sbjct: 119 NFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSL 177 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 WS DS +++ S D + KIW V S + T GH +YV F+ I + S D Sbjct: 178 TWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKD 237 Query: 151 ESVRIW-----------------------DVKTGKCLKT----LPAHSDPVSAVHFNRDG 183 +V +W D+ T A+ V V F+ Sbjct: 238 GAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPAT 297 Query: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD-NTLKLWD 242 L+ G R++D ++ L N PV+ V + G+++ + L +++ Sbjct: 298 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQN-PVNTVSVNQTGEWLAFGSSKLGQLLVYE 356 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 + + GH + + G +V+ SED + +W++ + + + HT Sbjct: 357 WQSESYILKQQGHFDSTNSL---AYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTS 413 Query: 303 VVISTACHPTENIIASAALENDKTIKLWK 331 V + ++ S++L D T++ W Sbjct: 414 SVTAVQFAKRGQVMFSSSL--DGTVRAWD 440 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 118/334 (35%), Gaps = 47/334 (14%) Query: 38 KFTLA-GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 FT H K ++++ + G L S D + + K S V +S Sbjct: 72 SFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFN-FKEKCSAVKFS 130 Query: 97 SDSNLLVSASDDKTLKIW---DVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSG 147 D L AS + L+IW DV+ + + GH + ++ S I++ Sbjct: 131 PDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT 189 Query: 148 SFDESVRIWDVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204 S D S +IW V + + T H D V F+ D I + S DG +W+ Sbjct: 190 SKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRP 249 Query: 205 CL--------------------------KTLIDDDNPPVSFVKFSPNGKYILAATLDNTL 238 K + V V F P + + Sbjct: 250 SDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEF 309 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED-NLVYIWNLQTKEIVQKL 297 +L+D ++ + +N + N + G+W+ GS + ++ Q++ + K Sbjct: 310 RLYDLPDFTLIQQLSMGQNPVNTVSVNQT---GEWLAFGSSKLGQLLVYEWQSESYILKQ 366 Query: 298 QGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 QGH D S A P + + +A+ D IK+W Sbjct: 367 QGHFDSTNSLAYSPDGSRVVTAS--EDGKIKVWD 398 Score = 130 bits (328), Expect = 6e-31, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 136/329 (41%), Gaps = 49/329 (14%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAW 95 T HT +V++V+F+ G+ + SSS D ++ W + +T +G ++ + +A Sbjct: 404 CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV 463 Query: 96 SSDSNLLVSASDDKT-LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 ++ + S D + +W V +G+ L L GH V C +F+ +++++ S S+D+++R Sbjct: 464 DPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIR 523 Query: 155 IWDV-KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--------------- 198 IW + + ++ + +SD V A+ DG + S+ G I+ Sbjct: 524 IWSIFGRSQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRK 582 Query: 199 DTASGQCLKTLIDDDNPPV----SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254 D SG+ + N + + +S +G I+A +N++ L+D LK + Sbjct: 583 DIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIV 642 Query: 255 HKNEKYCIFANFSVTGGKWIVSGSED--------------------NLVYIWNLQTKEIV 294 +N F + K +GS D +L T+++ Sbjct: 643 SRNMALNGTLEF-LNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMR 701 Query: 295 QKLQGHTDVVISTACHPTENIIASAALEN 323 V S PT N A+A+ E Sbjct: 702 -----PEVRVTSVQFSPTANAFAAASTEG 725 Score = 89.7 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 46/265 (17%), Positives = 93/265 (35%), Gaps = 44/265 (16%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 + +S D L+S ++ + ++D+ + K H + + N Q L++S D Sbjct: 45 ITFSDDGKQLLSPVGNR-VSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 103 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW---DTASGQCLKTL 209 + + K L + SAV F+ DG L +S +IW D + Sbjct: 104 AILVNFKARNVLHHFN-FKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPF 161 Query: 210 IDD-----DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYC 261 + ++ + +S + ++IL + D + K+W + T+ GH++ Sbjct: 162 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDY--- 218 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNL-------------------------QTKEIVQK 296 + F + I + S+D V++W + I +K Sbjct: 219 VMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 278 Query: 297 --LQGHTDVVISTACHPTENIIASA 319 + V HP ++A Sbjct: 279 HFFYANQAKVKCVTFHPATRLLAVG 303 Score = 28.0 bits (61), Expect = 6.0, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 18/30 (60%), Gaps = 1/30 (3%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 V+SV+FSP A++S + L+ I+ D Sbjct: 706 VTSVQFSPTANAFAAASTEGLL-IYSTNDT 734 >6G51-g nrPDB Length = 317 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 88/304 (28%), Positives = 143/304 (47%), Gaps = 20/304 (6%) Query: 1 MATEEKKPET--EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE 58 +AT + P+ A+R + T+ + P + L GH+ VS V S +G+ Sbjct: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIP----QRALRGHSHFVSDVVISSDGQ 76 Query: 59 WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118 + S S D +++W G + GH + VA+SSD+ +VS S DKT+K+W+ Sbjct: 77 FALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL- 135 Query: 119 GKCLKTL--KGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 G C T+ + HS +V C F+P S+ +IVS +D+ V++W++ K H+ + Sbjct: 136 GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYL 195 Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 + V + DGSL S DG +WD G+ L TL D ++ + FSPN +Y L A Sbjct: 196 NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSPN-RYWLCAAT 252 Query: 235 DNTLKLWDYSKGKCLKTY------TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 ++K+WD + T K E + G+ + +G DNLV +W + Sbjct: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312 Query: 289 QTKE 292 Sbjct: 313 TIGT 316 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 87/317 (27%), Positives = 148/317 (46%), Gaps = 28/317 (8%) Query: 34 NYALKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYDGK-----FEKTISGHK 87 L+ TL GH V+ + +P + + S+S DK I +W + ++ + GH Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHS 63 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 +SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSG Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 Query: 148 SFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203 S D+++++W+ G C T+ +HS+ VS V F+ + S +IVS +D L ++W+ A+ Sbjct: 124 SRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263 + LKT ++ V SP+G + D LWD ++GK L T G I Sbjct: 183 K-LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD----IIN 237 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL---------QGHTDVVISTACHPTEN 314 A W+ + + + IW+L+ K IV +L + S A Sbjct: 238 ALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQ 296 Query: 315 IIASAALENDKTIKLWK 331 + + D +++W+ Sbjct: 297 TLFAG--YTDNLVRVWQ 311 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 122/267 (45%), Gaps = 15/267 (5%) Query: 75 YDGKFEKTISGHKLGISDVAWSSD-SNLLVSASDDKTLKIW-----DVSSGKCLKTLKGH 128 T+ GH ++ +A + ++++SAS DKT+ +W + + G + L+GH Sbjct: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 Query: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 S++V + +SGS+D ++R+WD+ TG + H+ V +V F+ D IVS Sbjct: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK--YILAATLDNTLKLWDYSKG 246 S D ++W+T + + VS V+FSPN I++ D +K+W+ + Sbjct: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 K + GH + + G SG +D +W+L + + L G D++ + Sbjct: 183 KLKTNHIGHTGYLNTVTVS---PDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINA 238 Query: 307 TACHPTENIIASAALENDKTIKLWKSD 333 P + +A +IK+W + Sbjct: 239 LCFSPNRYWLCAATGP---SIKIWDLE 262 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 62/223 (27%), Positives = 98/223 (43%), Gaps = 11/223 (4%) Query: 116 VSSGKCLKTLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIWDVKTGK-----CLKTLPA 169 TLKGH+ +V PQ ++I+S S D+++ +W + + + L Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 HS VS V + DG +S S+DG R+WD +G + + V V FS + + I Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSSDNRQI 120 Query: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSEDNLVYIWNL 288 ++ + D T+KLW+ G C T + ++ FS IVS D LV +WNL Sbjct: 121 VSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179 Query: 289 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 ++ GHT + + P ++ AS D LW Sbjct: 180 ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLWD 220 Score = 87.4 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 11/139 (7%) Query: 200 TASGQCLKTLIDDDNPPVSFVKFSPN-GKYILAATLDNTLKLWDYSKGKC-----LKTYT 253 L+ + N V+ + +P IL+A+ D T+ +W ++ + + Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 313 GH + + + + G++ +SGS D + +W+L T ++ GHT V+S A Sbjct: 61 GHSHFVSDVVIS---SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117 Query: 314 NIIASAALENDKTIKLWKS 332 I S + DKTIKLW + Sbjct: 118 RQIVSGS--RDKTIKLWNT 134 >4V7E-Bg nrPDB Length = 380 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 24/314 (7%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98 TL GH+ V S+ ++P W+ S+S D + +W A + I H + + A++ + Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN 119 Query: 99 SNLLVSASDDKTLKIWDVSSGK-------CLKTLKGHSNYVFCCNFNP-QSNLIVSGSFD 150 + D I+++SS + L GH Y C + P Q +++GS D Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGD 179 Query: 151 ESVRIWDVKTGKCLKTL-----PAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQ 204 ++ +WDV TG+ + H+ V ++ N + ++ +S S D R+WD Sbjct: 180 QTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITS 239 Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY----TGHKNEKY 260 ++ VKF P+G+ + D T +L+D G L+ Y + NE Sbjct: 240 RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELP 299 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL----QGHTDVVISTACHPTENII 316 + + G+ + +G + Y+W+ E+V L H + + + Sbjct: 300 IVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSAL 359 Query: 317 ASAALENDKTIKLW 330 + + DK +K+W Sbjct: 360 CTGSW--DKNLKIW 371 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 18/229 (7%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTI-----SGHK 87 N + L GH SS ++ P+ E L + S D+ +W G+ SGH Sbjct: 146 NMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHT 205 Query: 88 LGISDVAWSS-DSNLLVSASDDKTLKIWDVS-SGKCLKTLKGHSNYVFCCNFNPQSNLIV 145 + ++ +S ++N+ +S S D T+++WD+ + + ++T GH + F P Sbjct: 206 ADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFG 265 Query: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDP-------VSAVHFNRDGSLIVSSSYDGLCRIW 198 +GS D + R++D++TG L+ D V++V F+ G L+ + +G C +W Sbjct: 266 TGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVW 325 Query: 199 DTASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244 DT + + TL + +S + S +G + + D LK+W +S Sbjct: 326 DTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 Score = 137 bits (345), Expect = 6e-33, Method: Composition-based stats. Identities = 52/242 (21%), Positives = 103/242 (42%), Gaps = 17/242 (7%) Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162 S + +T ++ + C +TL+GHS V+ ++ P+ N IVS S D + +W+ T + Sbjct: 40 YSKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQ 99 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS------GQCLKTLIDDDNPP 216 + H V F +G + D C I++ +S + ++ Sbjct: 100 KTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGY 159 Query: 217 VSFVKFSPNGK-YILAATLDNTLKLWDYSKGKCLKTY-----TGHKNEKYCIFANFSVTG 270 S ++ P+ + ++ + D T LWD + G+ + + +GH + + + + Sbjct: 160 ASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTAD--VLSLSINSLN 217 Query: 271 GKWIVSGSEDNLVYIWNLQ-TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 +SGS D V +W+L+ T V+ GH + S P + + +D T +L Sbjct: 218 ANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGS--DDGTCRL 275 Query: 330 WK 331 + Sbjct: 276 FD 277 Score = 57.7 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 43/137 (31%), Gaps = 53/137 (38%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-------------- 84 T GH ++SVKF P+G+ + S D +++ G + + Sbjct: 243 RTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVT 302 Query: 85 ---------------------------------------GHKLGISDVAWSSDSNLLVSA 105 H+ IS + SSD + L + Sbjct: 303 SVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTG 362 Query: 106 SDDKTLKIWDVSSGKCL 122 S DK LKIW S + + Sbjct: 363 SWDKNLKIWAFSGHRKI 379 >5OPT-p nrPDB Length = 318 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 80/291 (27%), Positives = 143/291 (49%), Gaps = 14/291 (4%) Query: 8 PETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK 67 +R + + + + + L GH+ VS V S NG++ S+S D Sbjct: 30 KAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDH 89 Query: 68 LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK- 126 +++W G + GH + V +S D+ +VS D L++W+V G+CL TL Sbjct: 90 SLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNV-KGECLHTLGR 148 Query: 127 -GHSNYVFCCNFNPQ--SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 183 H+++V C F+P + LIVSG +D V++WD+ +G+ L L H++ +++V + DG Sbjct: 149 GAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDG 208 Query: 184 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243 SL SS DG+ R+WD G+ L + P++ + FSPN +Y + A + ++++D Sbjct: 209 SLCASSDKDGVARLWDLTKGEALSEMAAG--APINQICFSPN-RYWMCAATEKGIRIFDL 265 Query: 244 SKGKCLKTYTGHKNEKY-----CIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 + +K C+ +S G + SG DN++ +W++ Sbjct: 266 ENKDVIVELAPEAQQKSKKTPECMSIAWSADGNT-LYSGYTDNVIRVWSVS 315 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 90/317 (28%), Positives = 153/317 (48%), Gaps = 32/317 (10%) Query: 37 LKFTLAGHTKAVSSVKFSP-NGEWL--ASSSADKLIKIW------GAYDGKF---EKTIS 84 + L GH V+++ ++ S+S D + W + + ++ E+ + Sbjct: 5 YEGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLE 64 Query: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144 GH +SDVA S++ + VSAS D +L++W++ +G C GH+ V F+P + I Sbjct: 65 GHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQI 124 Query: 145 VSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFNRD--GSLIVSSSYDGLCRIWDT 200 VSG D ++R+W+VK G+CL TL AH+D VS V F+ LIVS +D L ++WD Sbjct: 125 VSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260 ASG+ L T + ++ V SP+G ++ D +LWD +KG+ L Sbjct: 184 ASGRLL-TDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQ 242 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH-------TDVVISTACHPTE 313 F+ W+ + +E + I++L+ K+++ +L T +S A Sbjct: 243 ICFS----PNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADG 297 Query: 314 NIIASAALENDKTIKLW 330 N + S D I++W Sbjct: 298 NTLYSG--YTDNVIRVW 312 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 59/219 (26%), Positives = 107/219 (48%), Gaps = 13/219 (5%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVA 94 + GHTK V SV FSP+ + S D +++W G+ T+ H +S V Sbjct: 101 CQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVR 159 Query: 95 WSS--DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 +S ++ L+VS D +K+WD++SG+ L LKGH+NY+ +P +L S D Sbjct: 160 FSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGV 219 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 R+WD+ G+ L + A P++ + F+ + + +++ G RI+D + + L + Sbjct: 220 ARLWDLTKGEALSEMAA-GAPINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPE 277 Query: 213 ------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 P + +S +G + + DN +++W S+ Sbjct: 278 AQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 157 bits (397), Expect = 6e-39, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 114/266 (42%), Gaps = 20/266 (7%) Query: 83 ISGHKLGISDVA---WSSDSNLLVSASDDKTLKIW---------DVSSGKCLKTLKGHSN 130 + GH+ ++ +A + VS S D TL W + G + L+GHS Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190 +V + + VS S+D S+R+W+++TG C H+ V +V F+ D IVS Sbjct: 69 FVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGG 128 Query: 191 YDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSP--NGKYILAATLDNTLKLWDYSKGK 247 D R+W+ G+CL TL VS V+FSP I++ DN +K+WD + G+ Sbjct: 129 RDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGR 187 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307 L GH N + + G S +D + +W+L E + ++ + Sbjct: 188 LLTDLKGHTNYITSVTVS---PDGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQI 243 Query: 308 ACHPTENIIASAALENDKTIKLWKSD 333 P + +A + + L D Sbjct: 244 CFSPNRYWMCAATEKGIRIFDLENKD 269 >6BX3-A nrPDB Length = 314 Score = 211 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 110/323 (34%), Positives = 161/323 (49%), Gaps = 33/323 (10%) Query: 28 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGH 86 TPV LK T K SP+G++LA + I I+ +T+ + H Sbjct: 4 VTPVGTQNGLKAT---------CAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSH 53 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 S++ WS D + +ASDD +++I +S G L T GH+ V FN + NL+ + Sbjct: 54 ARPFSELCWSPDGQCIATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFT 112 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF-NRDGSLIVSSSYDGLCRIWDTASGQC 205 S DES++IWD G +KT+ AHS+ V +V D S++ S SYDGL RI+D +G C Sbjct: 113 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHC 172 Query: 206 LKTLIDDDN-------PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 LKTL D + P+S VKFS N +Y+L +LD +K+WD G ++T+ E Sbjct: 173 LKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLE 232 Query: 259 KYCIF-------ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG----HTDVVIST 307 K + N ++SG E+ +Y WN TK ++Q L G H+ V+S Sbjct: 233 KGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 292 Query: 308 ACHPTENIIASAALENDKTIKLW 330 C NI+ S AL D + W Sbjct: 293 HCF--GNIMCSLALNGDCCLWRW 313 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 46/211 (21%), Positives = 89/211 (42%), Gaps = 18/211 (8%) Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSY 191 C +P + + ++ I+D+ +TL +H+ P S + ++ DG I ++S Sbjct: 16 TCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 74 Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251 D I + G L T I PV + F+ G + +++D ++K+WD G +KT Sbjct: 75 DFSVEIIHLSYG-LLHTFI-GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 132 Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV-------- 303 + H + + + + + SGS D L+ I++ +T ++ L D Sbjct: 133 ISAHS--EAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 190 Query: 304 VISTACHPTENIIASAALENDKTIKLWKSDC 334 + + +L D +K+W DC Sbjct: 191 ISQVKFSENARYLLVKSL--DGVVKIW--DC 217 Score = 87.0 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 56/202 (27%), Positives = 93/202 (46%), Gaps = 25/202 (12%) Query: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGK 78 +SS +S N +L T++ H++AV SV + L+S S D LI+I+ A G Sbjct: 112 TSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH 171 Query: 79 FEKTISGHKL--------GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH-- 128 KT++ K IS V +S ++ L+ S D +KIWD G ++T + Sbjct: 172 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 231 Query: 129 SNYVFCCN-----FNP---QSNLIVSGSFDESVRIWDVKTGKCLKTLPA----HSDPVSA 176 V + NP + L++SG + + W+ T L+ L HS PV + Sbjct: 232 EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS 291 Query: 177 VHFNRDGSLIVSSSYDGLCRIW 198 +H G+++ S + +G C +W Sbjct: 292 IHC--FGNIMCSLALNGDCCLW 311 >6EOJ-D nrPDB Length = 470 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 68/255 (26%), Positives = 120/255 (47%), Gaps = 1/255 (0%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 ++ + + H AV+++K+S + +W+ S AD +IKIW ++ + H I D Sbjct: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 +A+SS+ + V+ SDD LKIW+ S+GK + L GH V C+++P+ LI S S D Sbjct: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 V++WD ++G C+ ++ V F G+L+++ S D CR++D + Sbjct: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 D+ ++ N A D +LK +D + T CI + G Sbjct: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 Query: 272 KWIVSGSEDNLVYIW 286 + ++D + W Sbjct: 363 HIFATAAKDRTIRFW 377 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 66/329 (20%), Positives = 139/329 (42%), Gaps = 10/329 (3%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD 66 +PET P++ + + + + + + +++++P G L ++ Sbjct: 56 EPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKV-KHVIPAIQWTPEGRRLVVATYS 114 Query: 67 KLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK 126 +W A FE + H ++ + +S DS+ ++S D +KIW + + Sbjct: 115 GEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA 174 Query: 127 GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186 H+ + F+ + V+ S D ++IW+ GK + L H V + ++ + LI Sbjct: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN-GKYILAATLDNTLKLWDYSK 245 S+S D L ++WD SG C+ +++ V +F P G ++A + D + +++D Sbjct: 235 ASASKDNLVKLWDPRSGNCISSILK-FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI-- 291 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL---QTKEIVQKLQGHTD 302 +K ++E + + D + ++L + I+ H Sbjct: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 Query: 303 VVISTACHPTENIIASAALENDKTIKLWK 331 + S + +P +I A+AA D+TI+ W Sbjct: 352 CITSLSYNPVGHIFATAA--KDRTIRFWT 378 >4V8M-A7 nrPDB Length = 318 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 95/318 (29%), Positives = 158/318 (49%), Gaps = 32/318 (10%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEW---LASSSADKLIKIWGAYDGKF---------EKTI 83 A + L GH V+S+ E + S+S DK + WG + ++ + Sbjct: 4 AYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRL 63 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 GH +SDVA S++ N VSAS D +L++W++ +G+C GH+ V F+P + Sbjct: 64 EGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQ 123 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHFNR--DGSLIVSSSYDGLCRIWD 199 IVSG D ++R+W+VK G+C+ TL AH+D VS V F+ D +IVS +D L ++WD Sbjct: 124 IVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259 A+G+ + T + V+ V SP+G ++ D +LWD +KG+ L Sbjct: 183 LATGRLV-TDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL----QGHTDVV---ISTACHPT 312 F+ W+ + +E + I++L+ K+I+ +L QG +V +S A Sbjct: 242 QICFS----PNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSAD 296 Query: 313 ENIIASAALENDKTIKLW 330 + + S D I++W Sbjct: 297 GSTLYSG--YTDNVIRVW 312 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 60/223 (26%), Positives = 110/223 (49%), Gaps = 13/223 (5%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGIS 91 N ++ GHTK V SV FSP+ + S D +++W G+ T+S H +S Sbjct: 98 NGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVS 156 Query: 92 DVAWSS--DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 V +S D+ ++VS D +K+WD+++G+ + LKGH+NYV +P +L S Sbjct: 157 CVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDK 216 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 D R+WD+ G+ L + A P++ + F+ + + +++ G RI+D + + L Sbjct: 217 DGVARLWDLTKGEALSEMAA-GAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVEL 274 Query: 210 IDDDN------PPVSFVKFSPNGKYILAATLDNTLKLWDYSKG 246 + P + +S +G + + DN +++W S+ Sbjct: 275 APEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 Score = 160 bits (404), Expect = 9e-40, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 121/266 (45%), Gaps = 20/266 (7%) Query: 83 ISGHKLGISDVA--WSSDS-NLLVSASDDKTLKIW---------DVSSGKCLKTLKGHSN 130 ++GH+ ++ +A + ++ +VS S DKTL W + S G + L+GHS Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190 +V + N VS S+D S+R+W+++ G+C H+ V +V F+ D IVS Sbjct: 69 FVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGG 128 Query: 191 YDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSP--NGKYILAATLDNTLKLWDYSKGK 247 D R+W+ G+C+ TL VS V+FSP + I++ DN +K+WD + G+ Sbjct: 129 RDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGR 187 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307 + GH N + + G S +D + +W+L E + ++ + Sbjct: 188 LVTDLKGHTNYVTSVTVS---PDGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQI 243 Query: 308 ACHPTENIIASAALENDKTIKLWKSD 333 P + +A + + L D Sbjct: 244 CFSPNRYWMCAATEKGIRIFDLENKD 269 >5UZ7-B nrPDB Length = 351 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 73/315 (23%), Positives = 132/315 (41%), Gaps = 9/315 (2%) Query: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE 80 S T + + + TL GH + ++ + + L S+S D + IW +Y Sbjct: 42 SQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKV 101 Query: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG----KCLKTLKGHSNYVFCCN 136 I + A++ N + D I+++ + + + L GH+ Y+ CC Sbjct: 102 HAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 161 Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196 F N IV+ S D + +WD++TG+ T H+ V ++ D L VS + D + Sbjct: 162 F-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAK 220 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 +WD G C +T ++ + F PNG + D T +L+D + L TY+ H Sbjct: 221 LWDVREGMCRQTFT-GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYS-HD 278 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 N I + G+ +++G +D +W+ + L GH + V + Sbjct: 279 NIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAV 338 Query: 317 ASAALENDKTIKLWK 331 A+ + D +K+W Sbjct: 339 ATGSW--DSFLKIWN 351 >4N14-A nrPDB Length = 314 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 83/317 (26%), Positives = 137/317 (43%), Gaps = 21/317 (6%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 + P P+ L + ++ V +S +G LA + D + +W A G + + Sbjct: 2 CRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQM 59 Query: 86 HKLG--ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 + G IS VAW + N L + +++WDV K L+ + HS V ++N S + Sbjct: 60 EQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWN--SYI 117 Query: 144 IVSGSFDESVRIWDVKTGK-CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 + SGS + DV+ + + TL HS V + + DG + S D L +W +A Sbjct: 118 LSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAP 177 Query: 203 GQ---CLKTLIDDDNPPVSFVKFSPNGKYILA---ATLDNTLKLWDYSKGKCLKTYTGHK 256 G+ V V + P +LA T D +++W+ G CL H Sbjct: 178 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 237 Query: 257 NEKYCIFANFSVTGGKWIVSGS--EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314 +++ K ++SG N + IW T V +L+GHT V+S P Sbjct: 238 QVCSILWSPHY----KELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGA 293 Query: 315 IIASAALENDKTIKLWK 331 +ASAA D+T++LW+ Sbjct: 294 TVASAAA--DETLRLWR 308 >6N9G-C nrPDB Length = 353 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 65/249 (26%), Positives = 117/249 (46%), Gaps = 12/249 (4%) Query: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSN 100 V + ++P+G +A D ++ K E K+++ H +S ++++ Sbjct: 107 WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDM 166 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ--SNLIVSGSFDESVRIWDV 158 +++AS D T +WDV SG+ L++ GH V C + P N VSG D+ +WD+ Sbjct: 167 QILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PV 217 ++G+C++ H V++V + G S S D CR++D + + + + Sbjct: 227 RSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGA 286 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277 S V FS +G+ + A D T+ +WD KG + GH+N + + G SG Sbjct: 287 SSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS---PDGTAFCSG 343 Query: 278 SEDNLVYIW 286 S D+ + +W Sbjct: 344 SWDHTLRVW 352 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 114/304 (37%), Gaps = 54/304 (17%) Query: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136 K +T+ GH + + W D +VS+S D + +WD + + +V C Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112 Query: 137 FNPQS------------------------------------------------NLIVSGS 148 + P I++ S Sbjct: 113 YAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172 Query: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLCRIWDTASGQCL 206 D + +WDV++G+ L++ H V + G+ VS D +WD SGQC+ Sbjct: 173 GDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 + + V+ V++ P+G + + D T +L+D + + Y+ +F Sbjct: 233 QAF-ETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF 291 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326 S++ G+ + +G D + +W++ V L GH + V + P S + D T Sbjct: 292 SLS-GRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSW--DHT 348 Query: 327 IKLW 330 +++W Sbjct: 349 LRVW 352 Score = 157 bits (396), Expect = 7e-39, Method: Composition-based stats. Identities = 53/210 (25%), Positives = 100/210 (47%), Gaps = 5/210 (2%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 A K ++A HT +S+ F+ + + ++S D +W G+ ++ GH + + Sbjct: 144 AKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203 Query: 96 SSD--SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 + N VS DK +WD+ SG+C++ + H + V + P + SGS D + Sbjct: 204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATC 263 Query: 154 RIWDVKTGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 R++D++ + + S S+V F+ G L+ + D +WD G + L Sbjct: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 323 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 +N VS ++ SP+G + + D+TL++W Sbjct: 324 HENR-VSTLRVSPDGTAFCSGSWDHTLRVW 352 >5Z56-q nrPDB Length = 504 Score = 200 bits (509), Expect = 6e-52, Method: Composition-based stats. Identities = 62/259 (23%), Positives = 127/259 (49%), Gaps = 7/259 (2%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91 K + + TL GHTK V+SV F P+ + + S+S D I+IW + + + H+ ++ Sbjct: 251 KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVT 310 Query: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCNFNPQSNLIVSGSF 149 ++ + + L+S+SDD+ D+ +G+ L + ++ + C F+P + +G+ Sbjct: 311 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTM 370 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 D ++IWD+K + P HS P++++ F+ +G + +++ D ++WD + KTL Sbjct: 371 DSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTL 430 Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269 D+N V + F +G Y+ D ++++ + + +T H + Sbjct: 431 QLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHA- 487 Query: 270 GGKWIVSGSEDNLVYIWNL 288 K+I S D + ++L Sbjct: 488 --KFIASTGMDRSLKFYSL 504 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 129/287 (44%), Gaps = 10/287 (3%) Query: 47 AVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105 + ++ P + + + ADK + ++ + T+ GH ++ V + +L+ SA Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSA 282 Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165 S D T++IW V + C++ ++ H + V + + + ++S S D+ D++TG+ L Sbjct: 283 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLT 342 Query: 166 TLPAHSD--PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 + + ++ F+ DG + + + D +IWD + + P++ + FS Sbjct: 343 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP-GHSGPITSIAFS 401 Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 NG Y+ A D+++KLWD K K KT N + + + G ++ G D + Sbjct: 402 ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE--VKSLIFDQSGTYLALGGTDVQI 459 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 YI + + H+ + A IAS + D+++K + Sbjct: 460 YI--CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 502 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 62/248 (25%), Positives = 117/248 (47%), Gaps = 7/248 (2%) Query: 89 GISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 GI + D+N +++ DK + ++D SS + L TLKGH+ V F+P +L+ S Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSA 282 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 S D ++RIW V C++ + AH V+ + + G ++SSS D D +G+ L Sbjct: 283 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLT 342 Query: 208 TLIDDDNP-PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 + D+ + ++ +F P+G T+D+ +K+WD + + + GH I + Sbjct: 343 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP---ITSIA 399 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD-VVISTACHPTENIIASAALE-ND 324 G ++ + ++D+ V +W+L+ + + LQ + V S + +A + Sbjct: 400 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 459 Query: 325 KTIKLWKS 332 K W Sbjct: 460 YICKQWTE 467 Score = 68.5 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 4/95 (4%) Query: 238 LKLWDYSKGKCLKTYTG-HKNEKYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 +K + SK + + ++ G H I A + + I++G D V +++ +++I+ Sbjct: 199 VKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILA 258 Query: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 L+GHT V S HP+++++ SA+ D TI++W Sbjct: 259 TLKGHTKKVTSVVFHPSQDLVFSASP--DATIRIW 291 >6HHQ-h nrPDB Length = 319 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 145/315 (46%), Gaps = 29/315 (9%) Query: 37 LKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-----DGKFEKTISGHKLGI 90 L+ TL GH V+S+ S L S+S DK + W G ++ GH + Sbjct: 9 LRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIV 68 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 D ++D +SAS DKTL++WDV++G+ + GH + V + + ++++I+SGS D Sbjct: 69 QDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRD 128 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHF------NRDGSLIVSSSYDGLCRIWDTASGQ 204 +++++W +K G+CL TL H+D VS V + D I+S+ D + + W+ Q Sbjct: 129 KTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQ 187 Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFA 264 I N ++ + SP+G I +A D + LW+ + K + T + +F+ Sbjct: 188 IEADFI-GHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDE----VFS 242 Query: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL--------QGHTDVVISTACHPTENII 316 W+ + + + +++L + +V L + +S A + Sbjct: 243 LAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTL 301 Query: 317 ASAALENDKTIKLWK 331 + D I++W+ Sbjct: 302 FAG--YTDNVIRVWQ 314 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 138/304 (45%), Gaps = 23/304 (7%) Query: 1 MATEEKKPET--EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE 58 +AT +P A+R + S T P + GH+ V + +G Sbjct: 23 LATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVP----VRSFKGHSHIVQDCTLTADGA 78 Query: 59 WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118 + S+S DK +++W G+ + GHK + V +++++S S DKT+K+W + Sbjct: 79 YALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTI-K 137 Query: 119 GKCLKTLKGHSNYVFCCNFNPQSN------LIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 G+CL TL GH+++V P I+S D+ V+ W++ + H+ Sbjct: 138 GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNS 197 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 ++ + + DG+LI S+ DG +W+ A+ + + TL V + FSPN ++ AA Sbjct: 198 NINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTL--SAQDEVFSLAFSPNRYWLAAA 255 Query: 233 TLDNTLKLWDYSKGKCLK----TYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 T +K++ + + G+ E + + +S G+ + +G DN++ +W Sbjct: 256 TATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSA-DGQTLFAGYTDNVIRVW 313 Query: 287 NLQT 290 + T Sbjct: 314 QVMT 317 Score = 78.1 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 61/138 (44%), Gaps = 13/138 (9%) Query: 205 CLKTLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLW-----DYSKGKCLKTYTGHKNE 258 L+ ++ N V+ + S +L+A+ D TL W D G ++++ GH + Sbjct: 8 VLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHI 67 Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318 G + +S S D + +W++ T E Q+ GH V+S ++I S Sbjct: 68 VQDCTLTA---DGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIIS 124 Query: 319 AALENDKTIKLW--KSDC 334 + DKTIK+W K C Sbjct: 125 GS--RDKTIKVWTIKGQC 140 >4LG8-A nrPDB Length = 354 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 62/259 (23%), Positives = 127/259 (49%), Gaps = 7/259 (2%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91 K + + TL GHTK V+SV F P+ + + S+S D I+IW + + + H+ ++ Sbjct: 101 KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVT 160 Query: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCNFNPQSNLIVSGSF 149 ++ + + L+S+SDD+ D+ +G+ L + ++ + C F+P + +G+ Sbjct: 161 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTM 220 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 D ++IWD+K + P HS P++++ F+ +G + +++ D ++WD + KTL Sbjct: 221 DSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTL 280 Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269 D+N V + F +G Y+ D ++++ + + +T H + Sbjct: 281 QLDNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAFGHHA- 337 Query: 270 GGKWIVSGSEDNLVYIWNL 288 K+I S D + ++L Sbjct: 338 --KFIASTGMDRSLKFYSL 354 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 129/287 (44%), Gaps = 10/287 (3%) Query: 47 AVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105 + ++ P + + + ADK + ++ + T+ GH ++ V + +L+ SA Sbjct: 73 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSA 132 Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165 S D T++IW V + C++ ++ H + V + + + ++S S D+ D++TG+ L Sbjct: 133 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLT 192 Query: 166 TLPAHSD--PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 + + ++ F+ DG + + + D +IWD + + P++ + FS Sbjct: 193 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP-GHSGPITSIAFS 251 Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 NG Y+ A D+++KLWD K K KT N + + + G ++ G D + Sbjct: 252 ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE--VKSLIFDQSGTYLALGGTDVQI 309 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 YI + + H+ + A IAS + D+++K + Sbjct: 310 YI--CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGM--DRSLKFY 352 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 62/248 (25%), Positives = 117/248 (47%), Gaps = 7/248 (2%) Query: 89 GISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 GI + D+N +++ DK + ++D SS + L TLKGH+ V F+P +L+ S Sbjct: 73 GILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSA 132 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 S D ++RIW V C++ + AH V+ + + G ++SSS D D +G+ L Sbjct: 133 SPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLT 192 Query: 208 TLIDDDNP-PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 + D+ + ++ +F P+G T+D+ +K+WD + + + GH I + Sbjct: 193 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP---ITSIA 249 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD-VVISTACHPTENIIASAALE-ND 324 G ++ + ++D+ V +W+L+ + + LQ + V S + +A + Sbjct: 250 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 309 Query: 325 KTIKLWKS 332 K W Sbjct: 310 YICKQWTE 317 Score = 66.6 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 4/95 (4%) Query: 238 LKLWDYSKGKCLKTYTG-HKNEKYCIFA-NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 +K + SK + + ++ G H I A + + I++G D V +++ +++I+ Sbjct: 49 VKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILA 108 Query: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 L+GHT V S HP+++++ SA+ D TI++W Sbjct: 109 TLKGHTKKVTSVVFHPSQDLVFSASP--DATIRIW 141 >3FM0-A nrPDB Length = 345 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 140/314 (44%), Gaps = 36/314 (11%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTI--SGHKLGISDVAWSSDSNLLVSASD 107 + ++P G LAS D+ I+IWG D K++ GH+ + VAWS N L SAS Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 108 DKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG---K 162 D T IW + +C+ TL+GH N V + P NL+ + S D+SV +W+V + Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141 Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL-KTLIDDDNPPVSFVK 221 C+ L +H+ V V ++ L+ S+SYD +++ + ++ V + Sbjct: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201 Query: 222 FSPNGKYILAATLDNTLKLWD-YSKG--------------KCLKTYTGHKNEKYCIFANF 266 F P+G+ + + + D T+++W Y G KC+ T +G + A Sbjct: 202 FDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC 261 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQK---------LQGHTDVVISTACHPTENIIA 317 +TG + + D+ + ++ Q+ Q H+ V A +P E + Sbjct: 262 QLTGA--LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGL- 318 Query: 318 SAALENDKTIKLWK 331 A+ +D + WK Sbjct: 319 LASCSDDGEVAFWK 332 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 121/291 (41%), Gaps = 34/291 (11%) Query: 34 NYALKFTL-AGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGI 90 ++ K L GH + V V +SP G +LAS+S D IW D + T+ GH+ + Sbjct: 49 SWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEV 108 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 VAW+ NLL + S DK++ +W+V +C+ L H+ V ++P L+ S Sbjct: 109 KSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASA 168 Query: 148 SFDESVRIW--DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW------- 198 S+D++V+++ + C TL H V ++ F+ G + S S D RIW Sbjct: 169 SYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGN 228 Query: 199 --------DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK--- 247 S +C+ TL + + + + + A D+ ++++ Sbjct: 229 EQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQ 288 Query: 248 ------CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 + H + C+ N G + S S+D V W Q E Sbjct: 289 QPTFSLTAHLHQAHSQDVNCVAWNPKEPG--LLASCSDDGEVAFWKYQRPE 337 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 45/207 (21%), Positives = 90/207 (43%), Gaps = 14/207 (6%) Query: 135 CNFNPQSNLIVSGSFDESVRIW--DVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSY 191 +NP L+ S D +RIW + + C L H V V ++ G+ + S+S+ Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 192 DGLCRIWDTASGQ-CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG---K 247 D IW T ++ V V ++P+G + + D ++ +W+ + + Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE--IVQKLQGHTDVVI 305 C+ H + + + S + + S S D+ V ++ + + L+GH V Sbjct: 142 CVSVLNSHTQDVKHVVWHPS---QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVW 198 Query: 306 STACHPTENIIASAALENDKTIKLWKS 332 S A P+ +AS + +D+T+++W+ Sbjct: 199 SLAFDPSGQRLASCS--DDRTVRIWRQ 223 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 53/124 (42%), Gaps = 4/124 (3%) Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 + F+ ++P G + + D +++W + + + + G Sbjct: 14 HPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG 73 Query: 272 KWIVSGSEDNLVYIW--NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 ++ S S D IW N E V L+GH + V S A P+ N++A+ + DK++ + Sbjct: 74 NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS--RDKSVWV 131 Query: 330 WKSD 333 W+ D Sbjct: 132 WEVD 135 Score = 51.2 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 31/92 (33%), Gaps = 5/92 (5%) Query: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL--QTKEIVQKL-QGHT 301 K + + + G + S D + IW + L +GH Sbjct: 2 KDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWKSD 333 V A P N +ASA+ D T +WK + Sbjct: 62 RTVRKVAWSPCGNYLASASF--DATTCIWKKN 91 >6J6H-n nrPDB Length = 455 Score = 194 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 12/299 (4%) Query: 36 ALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDV 93 + GH + +++KF P G + S D IKIW Y D + + GH I + Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 ++ D +S+S D+++KIWD +GK L +S + + + G + + Sbjct: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 Query: 154 RIWDVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 +D + + ++T H + A+ + DGS +SSS D RIW+ +K + Sbjct: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 Query: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS---KGKCLKTYTGHKNEKYCIFANFS 267 D + F+ P+ Y A ++DN + + K K + GH + Y I FS Sbjct: 333 DTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 Query: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD-VVISTACHPTEN--IIASAALEN 323 G++I SG + ++ W+ T ++ ++ + + HP E +I S A Sbjct: 393 -GDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGK 450 Score = 105 bits (261), Expect = 3e-23, Method: Composition-based stats. Identities = 49/262 (18%), Positives = 104/262 (39%), Gaps = 13/262 (4%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 +Y GH K + +++F+ + + SSS D+ +KIW GK + + + Sbjct: 195 DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVE 254 Query: 94 AWSSDSNLLVSASDDKTLKIWD---VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 + ++ + + + + +D + ++T H + + + P + +S S D Sbjct: 255 SRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSED 314 Query: 151 ESVRIWDVKTGKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS--GQC 205 ++VRIW+ + +K + HS P VH +++ + S D + + Sbjct: 315 KTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQN--YFCAQSMDNRIYSFSLKPKYKRH 372 Query: 206 LKTLIDDDNPPVS--FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263 K + + + FS +G+YI + + L WD++ + L N+ Sbjct: 373 PKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV 432 Query: 264 ANFSVTGGKWIVSGSEDNLVYI 285 K I SG+ +Y+ Sbjct: 433 DWHPQETSKVICSGAA-GKIYV 453 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 37/175 (21%), Positives = 74/175 (42%), Gaps = 9/175 (5%) Query: 161 GKCLKTLPAHSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219 K ++ P H + +A+ F G LI+S D +IWD N P+ Sbjct: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279 ++F+ + + L+++ D ++K+WD GK H N T + G Sbjct: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL--HLNSTP-ADVESRPTNPHEFIVGLS 268 Query: 280 DNLVYIWNLQTKE---IVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 ++ + ++ + E +VQ H +++ P + S++ DKT+++W+ Sbjct: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSS--EDKTVRIWE 321 Score = 80.8 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 40/178 (22%), Positives = 70/178 (39%), Gaps = 12/178 (6%) Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI---SGH 86 V N L T H ++ ++K+ P+G SSS DK ++IW K I + H Sbjct: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVS---SGKCLKTLKGHSNYVF--CCNFNPQS 141 + +V N + S D + + + K KGHS+ + F+ Sbjct: 338 SMPFLNV--HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG 395 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLP-AHSDPVSAVHFNR-DGSLIVSSSYDGLCRI 197 I SG + WD T + L + + P++ V ++ + S ++ S G + Sbjct: 396 RYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYV 453 Score = 63.1 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 40/93 (43%), Gaps = 5/93 (5%) Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQGHT 301 Y K ++ Y GH + F G I+SG D+ + IW+ E ++ QGH Sbjct: 149 YLPKKVIRNYPGHPEGTTAL--KFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHN 206 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWKSDC 334 + + S++ D+++K+W ++ Sbjct: 207 KPIKALRFTEDCQSFLSSSF--DRSVKIWDTET 237 >5WYJ-BC nrPDB Length = 817 Score = 194 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 78/269 (28%), Positives = 139/269 (51%), Gaps = 14/269 (5%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 ++T H K ++++ SPN A++S DK KIW +G+ E T++ HK G+ DV++ Sbjct: 484 EYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQ 543 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 LL ++S DKT+KIW + + +KTL+GH+N V C+F + ++S D ++IWD Sbjct: 544 YDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWD 603 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 +G+CLKTL H++ + A+ DG +IVS+ DG+ + W + Q ++ + V Sbjct: 604 CSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQV 663 Query: 218 SF--------VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269 K ++LA TLD+ ++L++ K ++ + E+ I F+ Sbjct: 664 EQEQSLQNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIFNEE 723 Query: 270 GGKWIVSGSEDNLVYI------WNLQTKE 292 + I +++ L+ + WN K Sbjct: 724 LDQAISILNDEQLILLMKRCRDWNTNAKT 752 Score = 179 bits (454), Expect = 1e-45, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 134/327 (40%), Gaps = 35/327 (10%) Query: 36 ALKFTLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGK--------FEKTISGH 86 + ++AG+ ++ +++ P LA ++ ++I D + GH Sbjct: 328 QVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGH 387 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC----LKTLKGHSNYVFCCNF----- 137 + ++ + + D + +AS D T +W + C GHS V Sbjct: 388 EDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVS 447 Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCL----------KTLPAHSDPVSAVHFNRDGSLIV 187 +++ S D +++ W + T AH ++A+ + + S+ Sbjct: 448 KGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFA 507 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK 247 ++SYD C+IW+ +G+ TL + + V F K + ++ D T+K+W Sbjct: 508 TASYDKTCKIWNLENGELEATLA-NHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFS 566 Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307 +KT GH N + + K ++S D L+ IW+ + E ++ L GH + + + Sbjct: 567 VMKTLEGHTN---AVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWAL 623 Query: 308 ACHPTENIIASAALENDKTIKLWKSDC 334 + ++I SA + D + WK DC Sbjct: 624 STMNDGDMIVSA--DADGVFQFWK-DC 647 Score = 107 bits (268), Expect = 5e-24, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 102/250 (40%), Gaps = 15/250 (6%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS 104 + ++++K +P+G++L S +L+KI+ GK +++ + S S LL Sbjct: 61 EQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKI-SSPSYILDADSTSTLLAV 119 Query: 105 ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN----LIVSGSFDESVRIWDVKT 160 D ++ + D+ +G + KGH + F Q N L+ SG + V++WD+ Sbjct: 120 GGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVK 179 Query: 161 GKCLKTLPAHSDPVSAVHF------NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD- 213 KCL TL H+ V + + ++S D + +WD + K L Sbjct: 180 RKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPV 239 Query: 214 NPPVSFVKFSPNG---KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270 N V F +G + I A D +L D G LK E + I ++ Sbjct: 240 NQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSN 299 Query: 271 GKWIVSGSED 280 + + S+ Sbjct: 300 SQMFLVLSDQ 309 Score = 90.8 bits (224), Expect = 7e-19, Method: Composition-based stats. Identities = 68/358 (18%), Positives = 126/358 (35%), Gaps = 50/358 (13%) Query: 17 PTPSSSATQSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGE----WLASSSADKLIKI 71 + T V N + + GH +SS+KF LAS + ++K+ Sbjct: 115 TLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKV 174 Query: 72 WGAYDGKFEKTISGHKLGISDVAWS--SDSN----LLVSASDDKTLKIWDVSSGKCLKTL 125 W K T+ H + + D++ L+S D + +WD + K K L Sbjct: 175 WDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLL 234 Query: 126 KGH--SNYVFCCNFNPQS---NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 K + V C F +I + D ++ D ++G LK + + + Sbjct: 235 KTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVL 294 Query: 181 R---DGSLIVSSSYDGLCRIW--------DTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 + + + S D ++ D + Q ++ + P + Sbjct: 295 PILSNSQMFLVLS-DQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKL 353 Query: 230 LAATLDNTLKLW---DYSKGKC-----LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 AT +L++ D S + ++ Y GH++ + + + G WI + S+DN Sbjct: 354 ALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHED---LLNSLDATEDGLWIATASKDN 410 Query: 282 LVYIWNLQ----TKEIVQKLQGHTDVVISTACHP-----TENIIASAALENDKTIKLW 330 +W +I K GH+ V + + +A+ ND TIK W Sbjct: 411 TAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTAS--NDLTIKKW 466 Score = 90.5 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 39/222 (17%), Positives = 80/222 (36%), Gaps = 13/222 (5%) Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLP-AHSDPV 174 G L + S+ V + ++ + DE + I D+ G K L + + Sbjct: 8 KGISLNPIYAGSSAVATVS--ENGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQEI 64 Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 +A+ DG + S L +I+ +G+ ++++ + + + Sbjct: 65 TALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYI--LDADSTSTLLAVGGT 122 Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI-VSGSEDNLVYIWNLQTKEI 293 D ++ + D G ++ GH + + W+ SG + +V +W+L ++ Sbjct: 123 DGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKC 182 Query: 294 VQKLQGHTDVVISTAC----HPTENIIASAALENDKTIKLWK 331 + LQ HT V E + + D I LW Sbjct: 183 LHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWD 224 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 42/204 (20%), Positives = 81/204 (39%), Gaps = 13/204 (6%) Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCL---KTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 S + +L + D + I D++ G K + P + S + Sbjct: 26 SENGKILATPVLD-EINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQL 84 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 ++I+ +KTGK ++++ S P + + +L+ DG + D +G + Sbjct: 85 LKIFHLKTGKVVRSMKI-SSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSF-KG 142 Query: 213 DNPPVSFVKFS--PNGKYILAATLD--NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 +S +KF N K L A+ D +K+WD K KCL T H + + Sbjct: 143 HGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVP 202 Query: 269 TGGK---WIVSGSEDNLVYIWNLQ 289 + ++SG D+++ +W+ Sbjct: 203 DNDEPSLNLLSGGRDDIINLWDFN 226 >6CHG-A nrPDB Length = 312 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 98/276 (35%), Positives = 154/276 (55%), Gaps = 17/276 (6%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 K L K +S + SP+GE +A ++ ++ K K + HK I+ + WS Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDML-VYEISSSKMMKLTTTHKECINCLCWSP 64 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 DS + S S+D T++I + G+ ++ L GH+ V +N + N++ S S DES++ W Sbjct: 65 DSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWH 123 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN-- 214 V +G LKT+ AHSD V ++ + D S++ S SYDGL RI+DT SG CLKTL D + Sbjct: 124 VLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWI 183 Query: 215 -----PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE-----KYCIFA 264 P+S VKFS NGK++L +LDN +KLW+Y++G ++T+ E KY Sbjct: 184 AEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGL 243 Query: 265 NFSVTGGK--WIVSGSEDNLVYIWNLQTKEIVQKLQ 298 GK ++SG++ + +WN+ +K +VQK+ Sbjct: 244 ELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKID 279 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 64/285 (22%), Positives = 133/285 (46%), Gaps = 23/285 (8%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK 81 T + + +K T H + ++ + +SP+ + +AS S D ++I G+ + Sbjct: 32 QNTDMLVYEISSSKMMKLTTT-HKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRI-R 89 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF-NPQ 140 + GH + + +++ N+L S+S D+++K W V SG LKT+ HS+ V + Sbjct: 90 RLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFD 149 Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD--------PVSAVHFNRDGSLIVSSSYD 192 S+++ SGS+D +RI+D ++G CLKTL D P+S V F+R+G ++ S D Sbjct: 150 SSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLD 209 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFS-------PNGK--YILAATLDNTLKLWDY 243 + ++W+ G ++T + + +K++ P GK +++ ++ +W+ Sbjct: 210 NVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNV 269 Query: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 ++ I + S + + S + ++ + Sbjct: 270 YSKNLVQKIDEKHRNSPLISISASYD---KVATLSLNGECNLFRV 311 >5L9T-R nrPDB Length = 493 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 117/280 (41%), Gaps = 16/280 (5%) Query: 60 LASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117 + S + +W A + + +S ++ V WS NL+ + ++IWD + Sbjct: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 259 Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVS 175 +GK L L+GH+ V +N + SGS D + D++T + + L H V Sbjct: 260 AGKKLSMLEGHTARVGALAWNA--EQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVC 317 Query: 176 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA---A 232 + ++ D L+ S D +W+ +S ++ + V + +SP+ +LA Sbjct: 318 GLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTE-HLAAVKAIAWSPHQHGLLASGGG 376 Query: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLVYIWNLQTK 291 T D ++ W+ G+ L+ +S + + + G N + +W + Sbjct: 377 TADRCIRFWNTLTGQPLQCIDTGSQ---VCNLAWSKHANELVSTHGYSQNQILVWKYPSL 433 Query: 292 EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 V KL GH+ V+ A P I + A D+T++ W Sbjct: 434 TQVAKLTGHSYRVLYLAMSPDGEAIVTGA--GDETLRFWN 471 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 116/270 (42%), Gaps = 16/270 (5%) Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89 + ++ G +V+SV +S G +A + ++IW A GK + GH Sbjct: 216 TSQVTRLCDLSVEG--DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTAR 273 Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 + +AW+++ L S S D+ + D+ + + + L+GH V ++ L+ SG Sbjct: 274 VGALAWNAE--QLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASG 331 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSS--YDGLCRIWDTASGQ 204 D + +W+ + ++ H V A+ ++ L+ S D R W+T +GQ Sbjct: 332 GNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 391 Query: 205 CLKTLIDDDNPPVSFVKFSPNGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 L+ + D V + +S + +++ N + +W Y + TGH Y + Sbjct: 392 PLQCI--DTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHS---YRV 446 Query: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 G+ IV+G+ D + WN+ +K Sbjct: 447 LYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476 Score = 108 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 41/205 (20%), Positives = 90/205 (43%), Gaps = 9/205 (4%) Query: 131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKT--LPAHSDPVSAVHFNRDGSLIVS 188 Y+ +++ + ++S V +W T + + L D V++V ++ G+L+ Sbjct: 189 YLNLVDWSSLN--VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAV 246 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 ++ G +IWD A+G+ L ++++ V + + N + + + + D + D Sbjct: 247 GTHKGFVQIWDAAAGKKL-SMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPL 303 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 + + +S T + + SG DN + +WN + VQ+ H V + A Sbjct: 304 QSERRLQGHRQEVCGLKWS-TDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362 Query: 309 CHPTEN-IIASAALENDKTIKLWKS 332 P ++ ++AS D+ I+ W + Sbjct: 363 WSPHQHGLLASGGGTADRCIRFWNT 387 >5FVM-C nrPDB Length = 303 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 134/284 (47%), Gaps = 16/284 (5%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY--DGKFEKTISGHKLGISDVA 94 T+ V+ ++ + + ++LA++ ++++ + + GHK ++ +A Sbjct: 24 CSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIRSNNPNPVSSFEGHKGNVTSIA 82 Query: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 + ++ +VS+S+D T+K+WDV S + K H+ V +P ++S D ++R Sbjct: 83 FQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEVAIHPNQGELISCDQDGNIR 141 Query: 155 IWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL---- 209 IWD+ +C L P + P+ ++ DGS++V+ + G C +W TL Sbjct: 142 IWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVT 201 Query: 210 -IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK-TYTGHKNEKY-CIFANF 266 ++ V S + K + + D+T ++W+ L+ T GH+ + C F+ Sbjct: 202 KFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFSAD 261 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310 S ++V+ D+ V +W+L T EIV++ GH + A + Sbjct: 262 SA----YLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALN 301 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 56/239 (23%), Positives = 104/239 (43%), Gaps = 8/239 (3%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 N + GH V+S+ F W+ SSS D IK+W ++ H +++V Sbjct: 64 NPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEV 122 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN-YVFCCNFNPQSNLIVSGSFDES 152 A + L+S D ++IWD+ +C L N + + +++V+G+ + Sbjct: 123 AIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGN 182 Query: 153 VRIW------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 +W D T + + +H+ ++ V + D + + S D R+W+ L Sbjct: 183 CYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQL 242 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 +T +D V FS + Y++ A D+ ++LWD S + ++ Y GH C+ N Sbjct: 243 ETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALN 301 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 52/241 (21%), Positives = 104/241 (43%), Gaps = 15/241 (6%) Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 +L SA D T++ W+ +G C +T++ + V + + VR++D+++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIRS 62 Query: 161 G--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 + + H V+++ F ++ +VSSS DG ++WD S + N PV+ Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK--HNAPVN 120 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 V PN +++ D +++WD + +C T N + + + G +V+G+ Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTP--LQSLSVASDGSMLVAGN 178 Query: 279 EDNLVYIW------NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 Y+W + T E V K + HT + +A+ + D T ++W Sbjct: 179 NKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSA--DHTARVWNI 236 Query: 333 D 333 + Sbjct: 237 E 237 >5K1B-B nrPDB Length = 677 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 68/282 (24%), Positives = 131/282 (46%), Gaps = 17/282 (6%) Query: 25 QSKPTPVKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83 + V+ +Y ++ + + + V++++ P L ++ D +I+IW K + I Sbjct: 9 TAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYI 68 Query: 84 SG---HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140 + H ++D+ + L+SAS D T+K+W+ G C+ TL+ H +YV + Sbjct: 69 ASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKD 128 Query: 141 SNLIVSGSFDESVRIWDVKTGKCL---------KTLPAHSDPVSAVHFNRDGSLIVSSSY 191 L+ S D + +WDV T L +L + D + ++ N+ G++IVS S Sbjct: 129 KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGST 188 Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251 + + R+WD + L L V + + +G L+ + D T++LW + +C+ T Sbjct: 189 EKVLRVWDPRTCAKLMKL-KGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIAT 247 Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293 Y H + + N + T + SG D +Y +L+ +I Sbjct: 248 YRVHDEGVWALQVNDAFTH---VYSGGRDRKIYCTDLRNPDI 286 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 104/247 (42%), Gaps = 14/247 (5%) Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC---LKTLKGHSNYVFCCNFNPQSNL 143 + G++ + N L +A D ++IW V+ K + +++ H+++V Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS- 202 ++S S D +V++W+ G C+ TL H D V A+ + +D L+ S+ D +WD + Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 203 -------GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 + + + + + + G I++ + + L++WD L GH Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGH 209 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315 + + N G +SGS D + +W+L + + + H + V + + Sbjct: 210 TDNVKALLLN---RDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTH 266 Query: 316 IASAALE 322 + S + Sbjct: 267 VYSGGRD 273 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 53/208 (25%), Positives = 96/208 (46%), Gaps = 12/208 (5%) Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC---LKTLPAHSDPVSAVHFNRDGSLIVS 188 V +P N + + D +RIW V K + ++ H+D V+ + +G ++S Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 +S D ++W+ G C+ TL V + ++ + + + +A LD + LWD + Sbjct: 93 ASSDTTVKVWNAHKGFCMSTL-RTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTA 151 Query: 249 LK------TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 L T + K I++ G IVSGS + ++ +W+ +T + KL+GHTD Sbjct: 152 LTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTD 211 Query: 303 VVISTACHPTENIIASAALENDKTIKLW 330 V + + S + +D TI+LW Sbjct: 212 NVKALLLNRDGTQCLSGS--SDGTIRLW 237 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 51/226 (22%), Positives = 96/226 (42%), Gaps = 18/226 (7%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK---------TISGHK 87 TL H V ++ ++ + E +AS+ D+ I +W ++SG+K Sbjct: 109 CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNK 168 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 I +A + ++VS S +K L++WD + L LKGH++ V N +SG Sbjct: 169 DSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSG 228 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 S D ++R+W + +C+ T H + V A+ N + + S D D + ++ Sbjct: 229 SSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IR 287 Query: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253 LI ++ PV ++ + D +W + + +T Sbjct: 288 VLICEEKAPVLKMELDR--------SADPPPAIWVATTKSTVNKWT 325 Score = 107 bits (266), Expect = 9e-24, Method: Composition-based stats. Identities = 42/272 (15%), Positives = 94/272 (34%), Gaps = 23/272 (8%) Query: 4 EEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASS 63 ++K+ A + N +L+G+ ++ S+ + G + S Sbjct: 127 KDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSG 186 Query: 64 SADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK 123 S +K++++W + GH + + + D +S S D T+++W + +C+ Sbjct: 187 STEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIA 246 Query: 124 TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDG 183 T + H V+ N + SG D + D++ + PV + +R Sbjct: 247 TYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSA 306 Query: 184 ---SLIVSSSYDGLCRIWDTA---SGQCLKTLIDDDNPPVSFVKFSPNG----------- 226 I ++ W + + +D P++ + P+ Sbjct: 307 DPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQC 366 Query: 227 ------KYILAATLDNTLKLWDYSKGKCLKTY 252 ++IL +N + WD K ++ Sbjct: 367 HILNDKRHILTKDTNNNVAYWDVLKACKVEDL 398 Score = 75.0 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 29/121 (23%), Positives = 53/121 (43%), Gaps = 8/121 (6%) Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKC---LKTYTGHKNEKYCIFANFSVTGGKW 273 V+ ++ P + A D+ +++W ++ K + + H + I GK Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCC---NGKT 89 Query: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 ++S S D V +WN + L+ H D V + A + ++ASA L D+ I LW + Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGL--DRQIFLWDVN 147 Query: 334 C 334 Sbjct: 148 T 148 >6EMK-B nrPDB Length = 303 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 133/284 (46%), Gaps = 16/284 (5%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF--EKTISGHKLGISDVA 94 T+ V+ ++ + + + LA++ ++++ + GH+ ++ V+ Sbjct: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVS 82 Query: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154 + D+ +V++S+D T+K+WDV S + K H+ V +P ++S D ++R Sbjct: 83 FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIR 141 Query: 155 IWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ-----CLKT 208 IWD+ +C L P + ++ DGS++ +++ G C +W+ + T Sbjct: 142 IWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT 201 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTGHKNEKY-CIFANF 266 + ++ + S + K++ + D+T ++W K T GH+ + C F+ Sbjct: 202 KFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310 S ++V+ S D+ V +W+L T+EIV++ GH + A + Sbjct: 262 SA----YLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 105/241 (43%), Gaps = 15/241 (6%) Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160 +LVSA D T++ W+ +G C +T++ + V L+ + ++VR++D++T Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRT 62 Query: 161 --GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 + + H V++V F +D +V+SS DG ++WD S + N PV+ Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPVN 120 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 V PN +++ D +++WD + +C T + + + + G + + + Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT--PEDDTSLQSLSMASDGSMLAAAN 178 Query: 279 EDNLVYIW------NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 Y+W + + V K + H+ + +A+ + D T ++W Sbjct: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA--DHTARVWSI 236 Query: 333 D 333 D Sbjct: 237 D 237 >3JAP-g nrPDB Length = 326 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 29/310 (9%) Query: 1 MATEEKKPE--TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE 58 ++T +P +R + S T+++ P + GH+ V V S +G Sbjct: 24 LSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVP----VRSYKGHSHIVQDVVVSADGN 79 Query: 59 WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS 118 + S+S DK +++W G E GH + VA ++S+ ++SAS DKT+++W+ Sbjct: 80 YAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTV- 138 Query: 119 GKCLKTLKGHSNYVFCCNFNPQSNL----------IVSGSFDESVRIWDVKTGK--CLKT 166 G C L GH+++V P++ VS D+ VR W + Sbjct: 139 GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEAD 198 Query: 167 LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG 226 H++ ++ V + DGSL S+ DG +W+ D V + FSP+ Sbjct: 199 FIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNF--DAKDEVFALAFSPSR 256 Query: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGH------KNEKYCIFANFSVTGGKWIVSGSED 280 ++ AAT +K++D + + + + +S G+ + +G D Sbjct: 257 FWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSA-DGQTLFAGYTD 314 Query: 281 NLVYIWNLQT 290 N++ +W + T Sbjct: 315 NVIRVWQVMT 324 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 138/320 (43%), Gaps = 33/320 (10%) Query: 37 LKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90 L+ TL GH V+S+ S L S S DK + W + G ++ GH + Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIV 69 Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 DV S+D N VSAS DKTL++W++++G GH+ V + S+ I+S S D Sbjct: 70 QDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRD 129 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR---------DGSL-IVSSSYDGLCRIWDT 200 +++R+W+ G C L H+D V+ V DG + VS+ D + R W Sbjct: 130 KTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSL 188 Query: 201 ASGQ-CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259 ++ N ++ V+ SP+G +A D + +W+ + K Sbjct: 189 NEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA----K 244 Query: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ----GHTDVV----ISTACHP 311 +FA W+ + + + I++L+ + ++ +L+ G+T +S A Sbjct: 245 DEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSA 303 Query: 312 TENIIASAALENDKTIKLWK 331 + + D I++W+ Sbjct: 304 DGQTLFAG--YTDNVIRVWQ 321 Score = 80.8 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 64/138 (46%), Gaps = 13/138 (9%) Query: 205 CLKTLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSKGKC-----LKTYTGHKNE 258 L+ ++ N V+ + S +++ + D TL W ++ + +++Y GH + Sbjct: 9 VLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHI 68 Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318 + + G + VS S D + +WNL T + GHT V+S A + I S Sbjct: 69 VQDVVVSA---DGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIIS 125 Query: 319 AALENDKTIKLWKS--DC 334 A+ DKTI++W + DC Sbjct: 126 AS--RDKTIRVWNTVGDC 141 >5XYI-g nrPDB Length = 335 Score = 184 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 134/321 (41%), Gaps = 30/321 (9%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-----KFEKTISGH 86 ++A + T GH A+ S++ +L S+S DK +W + GH Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 +SDV+ S D++ L+++S D TL++WD+S+ K GH V F+P + I+S Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIIS 139 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-----DGSLIVSSSYDGLCRIWDTA 201 D V+IW++ G+ L S V++V +I +DG IW Sbjct: 140 VGRDNQVKIWNI-LGENKAELQC-SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIE 197 Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261 L + + V F+P+GK+++ D + +W G ++T Sbjct: 198 KEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSP---- 253 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----------GHTDVVISTACH 310 + A + WI + + + + +W++ K+ + +Q G T A Sbjct: 254 VHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWA 312 Query: 311 PTENIIASAALENDKTIKLWK 331 +++ S ND +I+ W+ Sbjct: 313 ADGSVLYSG--YNDGSIRAWE 331 Score = 97.8 bits (242), Expect = 6e-21, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 83/290 (28%), Gaps = 103/290 (35%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFT-LAGHTKAVSSVKFSPNGEWLASSSADKLI 69 A+R + K + +A FT L GH VS V S + L +SS D + Sbjct: 50 SASRDKSALVW-----KLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTL 104 Query: 70 KIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV------------- 116 ++W +K GHK + V +S + ++S D +KIW++ Sbjct: 105 RLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSW 164 Query: 117 ---------------------------------SSGKCLKTLKGHSNYVFCCNFNPQSNL 143 K +K K H +F P Sbjct: 165 VTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKW 224 Query: 144 IVSGSFDESVRIWDVKTGK-----------------------CLKTLPA----------- 169 +++G D V +W + G C T Sbjct: 225 VITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQ 284 Query: 170 ---------HSD--------PVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 H + + + DGS++ S DG R W+ S Sbjct: 285 IDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 >6GMH-W nrPDB Length = 305 Score = 184 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 72/253 (28%), Positives = 127/253 (50%), Gaps = 4/253 (1%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 L+++L GH V SV S ASSS D I++W +GK K+I + +A+S Sbjct: 56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 DS L + + + I+ V SGK +L ++ ++P + SG+ D + I+ Sbjct: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175 Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216 D+ TGK L TL H+ P+ ++ F+ D L+V++S DG +I+D TL Sbjct: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS-GHASW 234 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 V V F P+ + ++++ D ++K+WD C+ T+ H+++ + + G IVS Sbjct: 235 VLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVK---YNGNGSKIVS 291 Query: 277 GSEDNLVYIWNLQ 289 +D ++I++ Sbjct: 292 VGDDQEIHIYDCP 304 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 140/296 (47%), Gaps = 12/296 (4%) Query: 42 AGHTKAVSSVKFS----PNGEWLASSSADKLIKIWGAYDGKFEK--TISGHKLGISDVAW 95 H A+ SV + N E + + S D L+K+W D + + ++ GH+LG+ V Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 S + S+S D +++WD+ +GK +K++ + F+P S + +G+ V I Sbjct: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 + V++GK +L + ++ ++ DG + S + DG+ I+D A+G+ L TL + Sbjct: 133 FGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAM 191 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 P+ + FSP+ + ++ A+ D +K++D T +GH + + V Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASW---VLNVAFCPDDTHFV 248 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 S S D V +W++ T+ V H D V + + I S +D+ I ++ Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVG--DDQEIHIYD 302 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 42/122 (34%), Positives = 66/122 (54%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 L TL GH + S+ FSP+ + L ++S D IKI+ T+SGH + +VA+ Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240 Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 D VS+S DK++K+WDV + C+ T H + V+ +N + IVS D+ + I Sbjct: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300 Query: 156 WD 157 +D Sbjct: 301 YD 302 Score = 58.1 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 25/81 (30%), Positives = 41/81 (50%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95 L TL+GH V +V F P+ SSS+DK +K+W T H+ + V + Sbjct: 223 NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY 282 Query: 96 SSDSNLLVSASDDKTLKIWDV 116 + + + +VS DD+ + I+D Sbjct: 283 NGNGSKIVSVGDDQEIHIYDC 303 Score = 28.0 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 19/43 (44%), Gaps = 6/43 (13%) Query: 293 IVQKLQGHTDVVISTAC----HPTENIIASAALENDKTIKLWK 331 + ++ Q H D + S A + + +L D +K+WK Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSL--DDLVKVWK 48 >5WBU-D nrPDB Length = 328 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 59/290 (20%), Positives = 123/290 (42%), Gaps = 18/290 (6%) Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGISDVA 94 T+ V++++ +P+ +A++ I+++ IS G I+ V Sbjct: 36 CTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVG 94 Query: 95 WSSDSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 + D + + +D T +IWD+ S +C + + + + C +P ++ G + Sbjct: 95 FHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN-APINCVCLHPNQAELIVGDQSGA 153 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ-------C 205 + IWD+KT + +P +++ H + D S + + + G C +W+ G Sbjct: 154 IHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLI 213 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG-----HKNEKY 260 KT I +FSP+ + + D T K+W S + + ++ + Sbjct: 214 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRG 273 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310 ++ ++IV+ S DNL +W ++T EI ++ GH V+ A + Sbjct: 274 WMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 99/246 (40%), Gaps = 16/246 (6%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 SD +L +A D T++ W SG C +T++ + V P ++I + + + +R++ Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGY-QHIRMY 70 Query: 157 DVKTGKC--LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214 D+ + + + + +++V F+ DG + + D RIWD S I N Sbjct: 71 DLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVN 130 Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274 P++ V PN ++ + +WD + + I + ++ Sbjct: 131 APINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS---ITSAHIDPDASYM 187 Query: 275 VSGSEDNLVYIWNLQTK--------EIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326 + + Y+WNL K+ HT + P ++A+ + D+T Sbjct: 188 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA--DQT 245 Query: 327 IKLWKS 332 K+W++ Sbjct: 246 CKIWRT 251 Score = 127 bits (318), Expect = 9e-30, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 102/253 (40%), Gaps = 16/253 (6%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISD 92 N + G K ++SV F +G W+ + D +IW + + I I+ Sbjct: 76 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINC 135 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 V + L+ + IWD+ + + + + + +P ++ + + + + Sbjct: 136 VCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGN 195 Query: 153 VRIWDVKTG--------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204 +W++ G +PAH+ F+ D +L+ + S D C+IW T++ Sbjct: 196 CYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFS 255 Query: 205 CLKTLI-------DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257 + L + + FS + +YI+ A+ DN +LW G+ + Y GH+ Sbjct: 256 LMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQK 315 Query: 258 EKYCIFANFSVTG 270 C+ N SV G Sbjct: 316 AVVCLAFNDSVLG 328 >4BTS-AR nrPDB Length = 343 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 135/327 (41%), Gaps = 48/327 (14%) Query: 41 LAGHTKAVSSVK--FSP----NGEWLASSSADKLIKIWGAYD-------GKFEKTISGHK 87 L GH+ V+S+ FS + L S S DK + IW Y+ G K ++GH Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 88 LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147 +SD+A S ++ +S+S DKTL++WD+ +G K GH + V+ F+P + I+S Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSA 136 Query: 148 SFDESVRIWDVKTGKCLKTL---PAHSDPVSAVHFN----------RDGSLIVSSSYDGL 194 + +++W++ G+C + HSD VS V ++ S +DG Sbjct: 137 GAEREIKLWNI-LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGR 195 Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254 ++W+ + ++ V+ + SPNGKYI D L +WD TY Sbjct: 196 LKVWN--TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILN----LTYPQ 249 Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT----------KEIVQKLQGHTDV- 303 + + + V+ D V I+NL T E + K +G Sbjct: 250 REFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKN 309 Query: 304 --VISTACHPTENIIASAALENDKTIK 328 S A + + + D I+ Sbjct: 310 PQCTSLAWNALGKKLFAG--FTDGVIR 334 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 96/232 (41%), Gaps = 28/232 (12%) Query: 123 KTLKGHSNYVFCCNF------NPQSNLIVSGSFDESVRIWDVKTGK-------CLKTLPA 169 L+GHS++V N S +++SGS D++V IW + + K L Sbjct: 15 GILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTG 74 Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 H+ VS + +++ +SSS+D R+WD +G K + V V FSP+ + I Sbjct: 75 HNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFV-GHQSEVYSVAFSPDNRQI 133 Query: 230 LAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCI-------FANFSVTGGKWIVSGSE 279 L+A + +KLW+ G+C H + C+ AN + S Sbjct: 134 LSAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGW 192 Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 D + +WN +I + H V + P IA+ DK + +W Sbjct: 193 DGRLKVWNTNF-QIRYTFKAHESNVNHLSISPNGKYIATGG--KDKKLLIWD 241 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 75/192 (39%), Gaps = 29/192 (15%) Query: 166 TLPAHSDPVSAVHF------NRDGSLIVSSSYDGLCRIWDTASGQC------LKTLIDDD 213 L HSD V+++ N D +++S S D IW + + Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273 N VS + S + ++++ D TL+LWD G K + GH++E Y + + Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSV---AFSPDNRQ 132 Query: 274 IVSGSEDNLVYIWNL--QTKEIVQKLQGHTDVVISTACHPT----------ENIIASAAL 321 I+S + + +WN+ + K + + H+D V P AS Sbjct: 133 ILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGW 192 Query: 322 ENDKTIKLWKSD 333 D +K+W ++ Sbjct: 193 --DGRLKVWNTN 202 Score = 97.0 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 41/270 (15%), Positives = 82/270 (30%), Gaps = 107/270 (39%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH VS + S + SSS DK +++W G K GH+ + VA+S D+ Sbjct: 72 LTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNR 131 Query: 101 LLVSASDDKTLKIWDV-------------------------------------------- 116 ++SA ++ +K+W++ Sbjct: 132 QILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVG 191 Query: 117 ---------SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--------- 158 ++ + T K H + V + +P I +G D+ + IWD+ Sbjct: 192 WDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQRE 251 Query: 159 ----------------------------------KTGKCLKTLP-----------AHSDP 173 ++ + T+ + Sbjct: 252 FDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQ 311 Query: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203 +++ +N G + + DG+ R + + Sbjct: 312 CTSLAWNALGKKLFAGFTDGVIRTFSFETS 341 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 65/168 (38%), Gaps = 17/168 (10%) Query: 10 TEAARAQPTP---SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD 66 A + QP +S + N+ +++T H V+ + SPNG+++A+ D Sbjct: 175 KSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKD 234 Query: 67 KLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL- 125 K + IW + + + I+ +A++ + + D+ +KI+++ + Sbjct: 235 KKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGT-DQGVKIFNLMTQSKAPVCT 293 Query: 126 ------------KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161 KG + +N + +G D +R + +T Sbjct: 294 IEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFETS 341 >2HES-X nrPDB Length = 330 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 126/307 (41%), Gaps = 34/307 (11%) Query: 15 AQPTPSSSATQSKPTPVKPNYALKFTL------AGHTKAVSSVKFSPNGEWLASSSADKL 68 +Q ++ +T K V Y FTL H KA+ SV + P+ LA+ S D Sbjct: 23 SQGILATGSTDRKIKLVSVKYD-DFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDST 81 Query: 69 IKIWGAYD-------GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG-- 119 + IW + I GH+ + VAWS+D L + S DK++ IW+ Sbjct: 82 VSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGE 141 Query: 120 --KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD--VKTGKCLKTLPAHSDPVS 175 +C+ L+ HS V ++P L+ S S+D++VRIW +C+ L H V Sbjct: 142 EYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVW 201 Query: 176 AVHFNRDGSLI--VSSSYDGLCRIW--------DTASGQCLKTLIDDDNPPVSFVKFSPN 225 + F++ + S S D R+W D C L D V V + N Sbjct: 202 SSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFN 261 Query: 226 GKYILAATLDNTLKLWDYSKGK---CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 G I + D L +++ G+ K H + + + G + +G +D + Sbjct: 262 G-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGI 320 Query: 283 VYIWNLQ 289 V W+L+ Sbjct: 321 VNFWSLE 327 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 114/280 (40%), Gaps = 31/280 (11%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV--SSGKCLKTL--KGHSNYVF 133 K++ +K I +S +L + S D+ +K+ V + L H + Sbjct: 5 NLIKSLKLYKEKIWSFDFSQ--GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIR 62 Query: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTGK-------CLKTLPAHSDPVSAVHFNRDGSLI 186 + P ++L+ +GSFD +V IW + L + H + V V ++ DG + Sbjct: 63 SVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYL 122 Query: 187 VSSSYDGLCRIWDTASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW-D 242 + S D IW+T +++ + + V V + P+ + +++ D+T+++W D Sbjct: 123 ATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKD 182 Query: 243 YSKG-KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW--------NLQTKEI 293 Y +C+ GH+ + + G + SGS+D+ V +W + Q Sbjct: 183 YDDDWECVAVLNGHEGTVWSSDFD-KTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVC 241 Query: 294 VQKLQ-GHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 L H V + A I A++ D + +++ Sbjct: 242 EAILPDVHKRQVYNVAWGFNGLI---ASVGADGVLAVYEE 278 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 55/262 (20%), Positives = 90/262 (34%), Gaps = 66/262 (25%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVKPNYA--LKFTLAGHTKAVSSVKFSPNGEWLASSS 64 +P T A S+ + +K + L + GH V V +S +G +LA+ S Sbjct: 67 RPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCS 126 Query: 65 ADKLIKIWGAYDG----KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW-DVSSG 119 DK + IW + + + H + V W LL S+S D T++IW D Sbjct: 127 RDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD 186 Query: 120 -KCLKTLKGHSNYVFCCNFNPQSNL--IVSGSFDESVRIW--------DVKTGKCLKTLP 168 +C+ L GH V+ +F+ + + SGS D +VR+W D + C LP Sbjct: 187 WECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILP 246 Query: 169 A-HSDPVSAVHFNRDG-------------------------------------------- 183 H V V + +G Sbjct: 247 DVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLEL 306 Query: 184 ---SLIVSSSYDGLCRIWDTAS 202 +++ + DG+ W Sbjct: 307 NGKTILATGGDDGIVNFWSLEK 328 Score = 63.5 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 46/122 (37%), Gaps = 12/122 (9%) Query: 221 KFSPNGKYILAATLDNTLKLWD--YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 F + + + D +KL Y + ++K + + +GS Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTS-LLAAGS 77 Query: 279 EDNLVYIW-------NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 D+ V IW +++ ++GH + V A +A+ + DK++ +W+ Sbjct: 78 FDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCS--RDKSVWIWE 135 Query: 332 SD 333 +D Sbjct: 136 TD 137 >5WYK-BB nrPDB Length = 943 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 135/330 (40%), Gaps = 28/330 (8%) Query: 22 SATQSKPTPVKPNYALKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79 S K P P T L G V S+ S + + LA++S + +KIW K Sbjct: 366 SIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKC 424 Query: 80 EKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-GHSNYVFCCNFN 138 +T + L++ + + L+++D++S L T++ H ++ + Sbjct: 425 IRTFE--CGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLT 482 Query: 139 PQSNLIVSGSFDESVRIWDVK---------TGKCLKTLPAH-------SDPVSAVHFNRD 182 +V+GS D++V+ WD K K L L H +D + V + D Sbjct: 483 SDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPD 542 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 + S D +++ S + +L PV + S + K I+ ++ D +K+W Sbjct: 543 DRYLAISLLDNTVKVFFLDSMKFYLSLY-GHKLPVLSIDISFDSKMIITSSADKNIKIWG 601 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 G C K+ H++ I + S S+D +V W+ + E +QKL H Sbjct: 602 LDFGDCHKSLFAHQDS---IMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQS 658 Query: 303 VVISTACHPTENIIASAALENDKTIKLWKS 332 V + A + S++ +D +I++W+ Sbjct: 659 EVWALAVATDGGFVVSSS--HDHSIRIWEE 686 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 119/272 (43%), Gaps = 24/272 (8%) Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 + G + + + S D+ LL +AS + +LKIW++ + KC++T + Y C F Sbjct: 382 THTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFE--CGYALTCKF 438 Query: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCR 196 P L++ G+ + ++++D+ + L T+ AH + ++ DG +V+ S D + Sbjct: 439 LPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVK 498 Query: 197 IWD---------TASGQCLKTLIDDD------NPPVSFVKFSPNGKYILAATLDNTLKLW 241 WD + L L + V+ SP+ +Y+ + LDNT+K++ Sbjct: 499 FWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVF 558 Query: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301 K + GHK I +F K I++ S D + IW L + + L H Sbjct: 559 FLDSMKFYLSLYGHKLPVLSIDISF---DSKMIITSSADKNIKIWGLDFGDCHKSLFAHQ 615 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWKSD 333 D +++ P + S + D +K W + Sbjct: 616 DSIMNVKFLPQSHNFFSCS--KDAVVKYWDGE 645 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 56/162 (34%), Positives = 87/162 (53%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS 104 T + V+ SP+ +LA S D +K++ KF ++ GHKL + + S DS ++++ Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIIT 590 Query: 105 ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 164 +S DK +KIW + G C K+L H + + F PQS+ S S D V+ WD + +C+ Sbjct: 591 SSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECI 650 Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 + L AH V A+ DG +VSSS+D RIW+ Q Sbjct: 651 QKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQVF 692 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 54/222 (24%), Positives = 103/222 (46%), Gaps = 17/222 (7%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA---------YDGKFEKTISGH------- 86 H A+ S+ + +G+ L + SADK +K W KF + H Sbjct: 471 AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL 530 Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 I V S D L + D T+K++ + S K +L GH V + + S +I++ Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIIT 590 Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 S D++++IW + G C K+L AH D + V F S S D + + WD +C+ Sbjct: 591 SSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECI 650 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 + L V + + +G ++++++ D+++++W+ ++ + Sbjct: 651 QKLY-AHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 58/346 (16%), Positives = 126/346 (36%), Gaps = 67/346 (19%) Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105 + ++ + + LA AD +IK+W +GHK I+ + + L+S Sbjct: 80 AECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISG 139 Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165 S D + +WD+ L L+ H + + + + ++S S D +++WD+KT +C++ Sbjct: 140 SKDSNIIVWDLVGEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIE 198 Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS------GQCLKTLIDDDNPPVSF 219 T AH+ + D L++++ D +IW G+ + I + Sbjct: 199 THIAHTGECWGLAVKDD--LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRG 256 Query: 220 VKF------SPNGKYILAATLDNTLKLWDYSKGKCL------------------------ 249 +K S + D T++ + K + + Sbjct: 257 LKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKS 316 Query: 250 -----KTYTGHKNE--------KYCIFANFSVTGGKWIVSGSEDNLVYIWNL-------- 288 ++ H + K + S + + +++ S N + +++ Sbjct: 317 IKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSS-NTIEYYSIPYEKRDPT 375 Query: 289 ---QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 K +LQG V S ++A+A+ + ++K+W Sbjct: 376 SPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS---NGSLKIWN 418 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 49/205 (23%), Positives = 88/205 (42%), Gaps = 23/205 (11%) Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTL-----PAHSD-------PVSAVHFNRDGSLIVS 188 LI S D V IWD+KTG + L P SD + + ++D L+ Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 DG+ ++WD S L + ++ ++F G +++ + D+ + +WD Sbjct: 97 GYADGVIKVWDLMSKTVLLNF-NGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVG 155 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 L HK+ F G W++S S+D ++ +W+L+T + ++ HT A Sbjct: 156 LYKLRSHKDSITG----FWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLA 211 Query: 309 CHPTENIIASAALENDKTIKLWKSD 333 + +I + D +K+WK D Sbjct: 212 V-KDDLLITTGT---DSQVKIWKLD 232 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 58/390 (14%), Positives = 126/390 (32%), Gaps = 104/390 (26%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 GH A++ ++F G L S S D I +W + HK I+ W + Sbjct: 117 FNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGF-WCQGED 175 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW--DV 158 L+S S D +K+WD+ + +C++T H+ C + +L+++ D V+IW D+ Sbjct: 176 WLISTSKDGMIKLWDLKTHQCIETHIAHTGE--CWGLAVKDDLLITTGTDSQVKIWKLDI 233 Query: 159 KTGK------CLKTLPAHSDP----VSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCL- 206 + K + S + + + D S + D + + + Sbjct: 234 ENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIA 293 Query: 207 ---------------------KTLIDDDNP-------------PVSFVKF---SPNGKYI 229 K++ + + + + S + + Sbjct: 294 RGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLEL 353 Query: 230 LAATLDNTLKLW-------DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 + T NT++ + D + LKT+T + + ++ +++ + + Sbjct: 354 VLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASNGS 413 Query: 283 VYIWNLQTKEIVQKLQ-----------------------------------------GHT 301 + IWN++T + ++ + H Sbjct: 414 LKIWNIKTHKCIRTFECGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHD 473 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWK 331 + S + + + DKT+K W Sbjct: 474 AAIWSLDLTSDGKRLVTGSA--DKTVKFWD 501 Score = 40.8 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 21/45 (46%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79 + L H V ++ + +G ++ SSS D I+IW + + Sbjct: 647 FECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 >5K0Y-T nrPDB Length = 329 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 63/313 (20%), Positives = 135/313 (43%), Gaps = 31/313 (9%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH ++++ +K++ G+ L + + D ++ +W + +G+ T GH + V D+ Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-----SFDESVRI 155 +++ S D + ++WD +GK L LK +S V C F+ N+I+ + V Sbjct: 66 HVLTGSADNSCRLWDCETGKQLALLKTNSA-VRTCGFDFGGNIIMFSTDKQMGYQCFVSF 124 Query: 156 WDVK------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 +D++ + +P + +++ + G I++ G + SG+ L + Sbjct: 125 FDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNV 184 Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269 + + ++ ++ S + A+ DNT KL+D + + KT+ E A S Sbjct: 185 -KEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR---TEPPRELAALSPN 240 Query: 270 GGKWIVSGSEDNL-------------VYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 +V G ++ + ++L +E +++GH + S A HP Sbjct: 241 YEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSY 300 Query: 317 ASAALENDKTIKL 329 +S D +++ Sbjct: 301 SSGG--EDGYVRI 311 Score = 88.1 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 35/169 (20%), Positives = 67/169 (39%), Gaps = 15/169 (8%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 + ++S + P GE + + + + A G+ + H I+D+ S + + V Sbjct: 145 NDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFV 204 Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES----------- 152 +AS D T K++D ++ + KT + +P +V G E+ Sbjct: 205 TASKDNTAKLFDSTTLEHQKTFRT-EPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIG 263 Query: 153 ---VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 R + + + + H P+++V F+ DG S DG RI Sbjct: 264 KFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIH 312 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 49/108 (45%), Gaps = 4/108 (3%) Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 L+ ++ +K++ G + D + +W G+ L TY GH +C+ A++ Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADW-- 62 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 K +++GS DN +W+ +T + + L+ V + NII Sbjct: 63 -DTKHVLTGSADNSCRLWDCETGKQLALLKT-NSAVRTCGFDFGGNII 108 Score = 71.2 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 47/130 (36%), Gaps = 15/130 (11%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 + H++ ++ ++ S ++S D K++ + + +KT A S + Sbjct: 184 VKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELA-ALSPNYE 242 Query: 101 LLVSASD----DKT----------LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 +V D T + + ++ + +KGH + F+P S Sbjct: 243 HVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSS 302 Query: 147 GSFDESVRIW 156 G D VRI Sbjct: 303 GGEDGYVRIH 312 Score = 53.5 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 29/83 (34%), Gaps = 5/83 (6%) Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 GH+ I G + + ++D +V +W E + GHT V Sbjct: 6 LQGHERS---ITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADW 62 Query: 312 TENIIASAALENDKTIKLWKSDC 334 + + + D + +LW + Sbjct: 63 DTKHVLTGSA--DNSCRLWDCET 83 >5MWJ-A nrPDB Length = 337 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 61/325 (18%), Positives = 123/325 (37%), Gaps = 17/325 (5%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 69 T + QP P + P P +A + H + V +V S + + + Sbjct: 18 TADGQMQPVPF--PPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK-GCV 74 Query: 70 KIWGAYDGKFEKTISG-----HKLGISDVAWSSDSNLLVSASDDKTLKIWDVS--SGKCL 122 K+W + +S I D L+ + TL IWD++ + + Sbjct: 75 KVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIK 134 Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182 L + + +P S + S D ++ +WD+ ++ H+D S + + D Sbjct: 135 AELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISND 194 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242 G+ + + D R WD G+ L+ D + + + P G+++ + +++ Sbjct: 195 GTKLWTGGLDNTVRSWDLREGRQLQQ--HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH 252 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 +K Y H +E + F+ GKW VS +DNL+ W + + + + Sbjct: 253 VNK---PDKYQLHLHESCVLSLKFAYC-GKWFVSTGKDNLLNAWRTPYGASIFQSK-ESS 307 Query: 303 VVISTACHPTENIIASAALENDKTI 327 V+S + I + + + T+ Sbjct: 308 SVLSCDISVDDKYIVTGSGDKKATV 332 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 39/208 (18%), Positives = 65/208 (31%), Gaps = 41/208 (19%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 P +K L A ++ SP+ + S +D I +W ++ + GH G S Sbjct: 129 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC 188 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCL------------------------------ 122 + S+D L + D T++ WD+ G+ L Sbjct: 189 IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNV 248 Query: 123 ----------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172 L H + V F VS D + W G + S Sbjct: 249 EVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESS 307 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 V + + D IV+ S D +++ Sbjct: 308 SVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 51.2 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 47/136 (34%), Gaps = 11/136 (8%) Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS---KGKCLKTYTGHKN 257 + + TL + V V S +++ +K+WD S + N Sbjct: 40 RHARQINTL--NHGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDC-LN 95 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNL--QTKEIVQKLQGHTDVVISTACHPTENI 315 I + + G ++ G E + + IW+L T I +L + A P + Sbjct: 96 RDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKV 155 Query: 316 IASAALENDKTIKLWK 331 S +D I +W Sbjct: 156 CFSCC--SDGNIAVWD 169 Score = 48.1 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 35/92 (38%), Gaps = 3/92 (3%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 S + N K+ L H V S+KF+ G+W S+ D L+ W Sbjct: 246 SNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW--RTPYGASIFQS 303 Query: 86 -HKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 + S D +V+ S DK +++V Sbjct: 304 KESSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 >5OQL-J nrPDB Length = 912 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 81/379 (21%), Positives = 142/379 (37%), Gaps = 70/379 (18%) Query: 17 PTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76 P+P+ + S+ ++P + T H + + P+ +A ++ + I+I D Sbjct: 349 PSPADVVSSSEGILLEPFRRISGT---HDEILDLTYILPDQSMMAIATNSEDIRIVSVKD 405 Query: 77 GKFEK-----------------TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS-- 117 + + GH+ + + + + S S D T ++W V Sbjct: 406 AQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPA 465 Query: 118 --SGKCLKTLKGHSNYVFCCNF-------------NPQSN---LIVSGSFDESVRIWDV- 158 S C GH V NP + ++SGS D V+ D+ Sbjct: 466 NNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIP 525 Query: 159 ----KTGKCLKTLP--AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 K GK +L AH ++A+ + +G L S+S D +IWD + ++ ++ Sbjct: 526 RQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLE-VQGILRG 584 Query: 213 DNPPVSFVKFSPNGK--------------YILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 V V+F+P +L + D T+KLW+ S C++T+ GH + Sbjct: 585 HKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHN 644 Query: 259 KYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 + S D LV +W+ T E L H D + + A H Sbjct: 645 VLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSK 704 Query: 313 ENIIASAALENDKTIKLWK 331 NI+ASA +D + W+ Sbjct: 705 TNILASAG--SDSKVTFWR 721 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 68/354 (19%), Positives = 134/354 (37%), Gaps = 74/354 (20%) Query: 55 PNGEWLASSSADKLIKIWGAYDG------------KFEKTISGHKLGISDVAWS-SDSNL 101 P + + AD + ++ + + ISG I D+ + D ++ Sbjct: 329 PERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSM 388 Query: 102 LVSASDDKTLKI--------WDVSSGKC---------LKTLKGHSNYVFCCNFNPQSNLI 144 + A++ + ++I + + +C + LKGH + V + + + I Sbjct: 389 MAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWI 448 Query: 145 VSGSFDESVRIWDV----KTGKCLKTLPAHSDPVSAVHF----------------NRDGS 184 SGS D + R+W V + C H + V AV + + Sbjct: 449 ASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPA 508 Query: 185 LIVSSSYDGLCRIWDT-----ASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTL 238 ++S S D + D G+ +L + ++ + SPNGK +A+ D T+ Sbjct: 509 FLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTV 568 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANF-----------SVTGGKWIVSGSEDNLVYIWN 287 K+WD K + GHK + + SV+G +++GS D + +WN Sbjct: 569 KIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWN 628 Query: 288 LQTKEIVQKLQGHTDVVISTAC---HPTENIIAS----AALENDKTIKLWKSDC 334 L ++ +GH+ V+ ++I + A+ D +K+W ++ Sbjct: 629 LSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANT 682 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 126/347 (36%), Gaps = 61/347 (17%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--------GAYDGKFEKTISGHKLGISD 92 + G + +S++ +P+G L S ++I+ + + +T H + Sbjct: 57 IQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVV 116 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF--------------- 137 +A S LL + + D +KIWD+ G T+ G S V +F Sbjct: 117 LAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKK 176 Query: 138 ---------NPQSNLIVS------GSFDESVRIWDVKTGKCLKTL-------PAHSDPVS 175 N ++ I S G+ D +RI+D+ AH V Sbjct: 177 PKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQ 236 Query: 176 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 235 + ++ + ++S S D +W G T + + V F GK++ +A Sbjct: 237 CIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHE-LLESVGFLNEGKWMYSAGTS 295 Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK---- 291 L++WD + + K+E I + S+ I+ D + ++ + + Sbjct: 296 GVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVV 355 Query: 292 --------EIVQKLQGHTDVVISTAC-HPTENIIASAALENDKTIKL 329 E +++ G D ++ P ++++A A D I++ Sbjct: 356 SSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSED--IRI 400 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 139/370 (37%), Gaps = 72/370 (19%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91 L T H V + LA+ +AD IKIW G T+SG + +S Sbjct: 98 SVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVS 157 Query: 92 DVAW------------------------SSDSNLLVS------ASDDKTLKIWDV----- 116 + + + D++ + S + D ++I+D+ Sbjct: 158 ALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTT 217 Query: 117 --SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 + + H + V C ++P+ + ++SGS D+++ +W + G T + + Sbjct: 218 TPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELL 277 Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--KTLIDDDNPPVSFVKFSPNGKYILAA 232 +V F +G + S+ G+ RIWDT + + K + + P IL A Sbjct: 278 ESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCA 337 Query: 233 TLDNTLKLWDY---------SKGKCLKTY---TGHKNEKYCIFANFSVTGGKWIVSGSED 280 D TL L+ S+G L+ + +G +E + I + SED Sbjct: 338 QADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSED 397 Query: 281 NLVYI--------WNLQTKEI---------VQKLQGHTDVVISTACHPTENIIASAALEN 323 + I ++ E V L+GH D+V+S + + IAS + Sbjct: 398 --IRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGS--K 453 Query: 324 DKTIKLWKSD 333 D T +LW+ D Sbjct: 454 DNTARLWRVD 463 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 120/329 (36%), Gaps = 53/329 (16%) Query: 50 SVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDK 109 SV LAS+ + I GK I G IS + + + L+ S Sbjct: 25 SVALENGARILASTLGENAILT-ELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSL 83 Query: 110 TLKI--------WDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161 T++I +D ++T K H+ V + S L+ +G+ D +++IWD+ G Sbjct: 84 TMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGG 143 Query: 162 KCLKTLPAHSDPVSAVHF------------------------NRDGSLIVS------SSY 191 T+ S VSA+HF N D I S + Sbjct: 144 YVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQ 203 Query: 192 DGLCRIWDTASGQ------CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 DG RI+D K + V + +SP +L+ + D T+ LW + Sbjct: 204 DGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRD 263 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK---EIVQKLQGHTD 302 G T + + + GKW+ S ++ IW+ T Q + + Sbjct: 264 GIWQGT---PMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGE 320 Query: 303 VVISTACHPTENIIASAALENDKTIKLWK 331 ++S P ++I A + D T+ L++ Sbjct: 321 AILSAVSLPERSLILCA--QADFTLVLYR 347 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 42/177 (23%), Positives = 71/177 (40%), Gaps = 27/177 (15%) Query: 7 KPETEAARAQP--TPSSSATQSKPTPVK--PNYALKFTLAGHTKAVSSVKFSP------- 55 + A P +SA+Q K + ++ L GH + V +V+F+P Sbjct: 544 DKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQ 603 Query: 56 ------NGE-WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-------- 100 +G + + S DK IK+W D +T GH + V W S Sbjct: 604 GEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTK 663 Query: 101 -LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 SA D +K+WD ++G+ TL H + ++ + ++N++ S D V W Sbjct: 664 VQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 >4AEZ-A nrPDB Length = 401 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 77/339 (22%), Positives = 138/339 (40%), Gaps = 19/339 (5%) Query: 2 ATEEKKP-ETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60 A E KKP + +P + P L ++ + +S N + Sbjct: 49 APEAKKPVDLRTQHNRPQRPVVTPAKRRFNTTPERVLDAPGIIDDYYLNLLDWS-NLNVV 107 Query: 61 ASSSADKLIKIWGAYDGKFEKTISG-HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119 A + + +W A G ++ V WS D + L + + I+DV S Sbjct: 108 AVALERN-VYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQ 166 Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVH 178 L+T+ GH V C ++N +++ SGS ++ DV+ + TL HS V + Sbjct: 167 TKLRTMAGHQARVGCLSWN--RHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLA 224 Query: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA---ATLD 235 + DG + S D + +IWD S K + N V V + P +LA T+D Sbjct: 225 WRSDGLQLASGGNDNVVQIWDARS-SIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMD 283 Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLVYIWNLQTKEIV 294 + W+ + G + T I +S + + + G DN + IW+ + + Sbjct: 284 KQIHFWNAATGARVNTVDAGSQVTSLI---WSPHSKEIMSTHGFPDNNLSIWSYSSSGLT 340 Query: 295 QKL--QGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 +++ H V+ +A P I+++AA +D+ +K W+ Sbjct: 341 KQVDIPAHDTRVLYSALSPDGRILSTAA--SDENLKFWR 377 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 119/258 (46%), Gaps = 11/258 (4%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS 104 + V+SVK+S +G +L+ + L+ I+ +T++GH+ + ++W+ ++L S Sbjct: 134 STYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNR--HVLSS 191 Query: 105 ASDDKTLKIWDVS-SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163 S + DV + + TL+GHS+ V + + SG D V+IWD ++ Sbjct: 192 GSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIP 251 Query: 164 LKTLPAHSDPVSAVHFNR-DGSLIVSSS--YDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 T H+ V AV + +L+ + D W+ A+G + T+ D V+ + Sbjct: 252 KFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTV--DAGSQVTSL 309 Query: 221 KFSPNGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 +SP+ K I++ DN L +W YS K ++ +++ S G+ + + + Sbjct: 310 IWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALS-PDGRILSTAA 368 Query: 279 EDNLVYIWNLQTKEIVQK 296 D + W + + V++ Sbjct: 369 SDENLKFWRVYDGDHVKR 386 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 59/219 (26%), Positives = 94/219 (42%), Gaps = 10/219 (4%) Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSS 97 T+AGH V + ++ L+S S I T+ GH + +AW S Sbjct: 170 RTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRS 227 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGS--FDESVR 154 D L S +D ++IWD S T H+ V + P QSNL+ +G D+ + Sbjct: 228 DGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIH 287 Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY--DGLCRIWDTASGQCLKTL-ID 211 W+ TG + T+ A S V+++ ++ I+S+ D IW +S K + I Sbjct: 288 FWNAATGARVNTVDAGSQ-VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIP 346 Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 250 + V + SP+G+ + A D LK W G +K Sbjct: 347 AHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVK 385 Score = 90.1 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 41/192 (21%), Positives = 78/192 (40%), Gaps = 9/192 (4%) Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 +V+ + + +V +W+ +G V++V ++ DGS + +GL I+D S Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVES 165 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS-KGKCLKTYTGHKNEKYC 261 L+T+ V + + N + + + + D + T GH +E Sbjct: 166 QTKLRTMA-GHQARVGCLSW--NRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCG 222 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP-TENIIASAA 320 + + G + SG DN+V IW+ ++ H V + A P N++A+ Sbjct: 223 LAWR---SDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGG 279 Query: 321 LENDKTIKLWKS 332 DK I W + Sbjct: 280 GTMDKQIHFWNA 291 Score = 67.3 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 8/135 (5%) Query: 38 KFTLAGHTKAVSSVKFSP-NGEWLASSS--ADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 KFT H AV +V + P LA+ DK I W A G T+ ++ + Sbjct: 252 KFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-VTSLI 310 Query: 95 WSSDSNLLVS--ASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150 WS S ++S D L IW SS + H V +P ++ + + D Sbjct: 311 WSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASD 370 Query: 151 ESVRIWDVKTGKCLK 165 E+++ W V G +K Sbjct: 371 ENLKFWRVYDGDHVK 385 >3ODT-A nrPDB Length = 313 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 138/305 (45%), Gaps = 23/305 (7%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 94 Y L TL GH + V V + + +AS S D +++W D + + ++ V Sbjct: 8 YQLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVC 66 Query: 95 WSSDSNLLVSASDDKTLK---IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151 + S+ LL+ D + ++ S L TL GH V +F Q +++SGS+D+ Sbjct: 67 YDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF--QDGVVISGSWDK 124 Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSA---VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208 + ++W K G + L AH+ V V F+ + +++S D ++W + + +KT Sbjct: 125 TAKVW--KEGSLVYNLQAHNASVWDAKVVSFSEN--KFLTASADKTIKLW--QNDKVIKT 178 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 N V + +G + ++ + D +KL D G L+TY GH++ YCI + Sbjct: 179 FSGIHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNG 237 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 328 IVS ED V IW+ + + Q + + S C +II ++ D ++ Sbjct: 238 D----IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSS---DNLVR 290 Query: 329 LWKSD 333 ++ + Sbjct: 291 IFSQE 295 Score = 117 bits (293), Expect = 7e-27, Method: Composition-based stats. Identities = 55/186 (29%), Positives = 90/186 (48%), Gaps = 7/186 (3%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLIKIWGAYDGKFE 80 S + K V +L + L H +V K S + ++SADK IK+W + K Sbjct: 119 SGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QNDKVI 176 Query: 81 KTISG-HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139 KT SG H + +A D + + S S+D +K+ D+ +G L+T +GH ++V+C P Sbjct: 177 KTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLP 235 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 + IVS D +VRIW + G + + + + +V +G +IV S D L RI+ Sbjct: 236 NGD-IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIV-GSSDNLVRIFS 293 Query: 200 TASGQC 205 + Sbjct: 294 QEKSRW 299 >4YCZ-A nrPDB Length = 876 Score = 174 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 110/266 (41%), Gaps = 46/266 (17%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS--SGKCLKTLKGHSNYVFCCNF-NP- 139 SGH I D L + S D+T+KI+++ + + +TLKGH V+C ++ +P Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAVHFNRD--GSLIVSSSYDGLC 195 N++ S +D V IW G + H V+ V ++ G L+ +S DG Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 + + ++ V+ V ++P S G + + G Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAPA-----------------TSPGSIVSSKPGP 177 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDVVISTACH 310 K+ TG + V+G DN + IW KL+ GHTD V A Sbjct: 178 KS-----------TGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWS 226 Query: 311 P---TENIIASAALENDKTIKLWKSD 333 P ++ IASA+ D+T+++W SD Sbjct: 227 PTVLQKSYIASAS--EDRTVRIWTSD 250 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 109/293 (37%), Gaps = 36/293 (12%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFEKTISGHKLGISDVAWSS-- 97 +GH + G LA+ S+D+ IKI+ + +T+ GH + V+W+ Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKG--HSNYVFCCNFNPQSN--LIVSGSFDESV 153 N+L SA D + IW +G + H V +++P L+ S D +V Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 154 RIWDVKTGKCLKT-LPAHSDPVSAVHFNRDGS-----------------LIVSSSYDGLC 195 + + + + AH V++V + S V+ D Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNAL 194 Query: 196 RIW----DTASGQCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLWDYSKGKC 248 +IW T + + + + V V +SP YI +A+ D T+++W Sbjct: 195 KIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANP 254 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK---EIVQKLQ 298 L+ N ++ G + + DN V +W K E V+ ++ Sbjct: 255 LQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTIE 307 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 34/236 (14%) Query: 40 TLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAW 95 TL GH AV V ++ G LAS+ D + IW +G +++ + HK ++ V+W Sbjct: 57 TLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSW 116 Query: 96 SS--DSNLLVSASDDKTLKIWDVSSGKCLK-TLKGHSNYVFCCNFNP------------- 139 S LL AS D + + + H V ++ P Sbjct: 117 SPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPG 176 Query: 140 ----QSNLIVSGSFDESVRIWDVKTGKCLKTLP-----AHSDPVSAVHFNRD---GSLIV 187 + V+G D +++IW L H+D V V ++ S I Sbjct: 177 PKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIA 236 Query: 188 SSSYDGLCRIWDTASGQCLKT--LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 S+S D RIW + L+ + + + V V +S +G + A+ DN + LW Sbjct: 237 SASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 49/211 (23%), Positives = 86/211 (40%), Gaps = 34/211 (16%) Query: 35 YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKT-ISGHKLGIS 91 + F A H +V+ V +SP+ G LA +S+D + + D +E + H LG++ Sbjct: 98 WQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVN 157 Query: 92 DVAWSSD-----------------SNLLVSASDDKTLKIWDVSSGKCLKT-----LKGHS 129 V+W+ + V+ D LKIW L GH+ Sbjct: 158 SVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHT 217 Query: 130 NYVFCCNFNP---QSNLIVSGSFDESVRIWDVKTGKCLK---TLPAHSDPVSAVHFNRDG 183 ++V ++P Q + I S S D +VRIW L+ + V V ++ G Sbjct: 218 DWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSG 277 Query: 184 SLIVSSSYDGLCRIWDTA---SGQCLKTLID 211 +++ +S D +W +C+KT+ + Sbjct: 278 NVLAASGGDNKVTLWKENLKGEWECVKTIEE 308 Score = 31.1 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 33/86 (38%), Gaps = 13/86 (15%) Query: 1 MATEEKKPETEAARA--------QPTPSSSATQSKPTPVK---PNYALKFTLA--GHTKA 47 + E T+ R Q + +SA++ + + P L++ A Sbjct: 208 LEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAA 267 Query: 48 VSSVKFSPNGEWLASSSADKLIKIWG 73 V V +S +G LA+S D + +W Sbjct: 268 VWRVSWSLSGNVLAASGGDNKVTLWK 293 >5A31-R nrPDB Length = 386 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 121/285 (42%), Gaps = 14/285 (4%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT 110 + +S + LA + K I + G + ++W + L + Sbjct: 98 IDWSST-DVLAVALG-KSIFLTDNNTGDVVHLCDTENEY-TSLSWIGAGSHLAVGQANGL 154 Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL-KTLPA 169 ++I+DV KC++TL GH + V C ++N ++++ SGS D + DV+ +T+ + Sbjct: 155 VEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRDVRMPDPFFETIES 212 Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 H+ V + +N + + S D + +++ S + T D+ V + +SP+ + + Sbjct: 213 HTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF-DEHKAAVKAMAWSPHKRGV 271 Query: 230 LA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 LA T D LK+W+ + +K + C T G + +W Sbjct: 272 LATGGGTADRRLKIWNVNT--SIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLW 329 Query: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + + + + L+GH+ V+ + S A D+T++ WK Sbjct: 330 DCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA--GDETLRYWK 372 Score = 120 bits (302), Expect = 7e-28, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 103/246 (41%), Gaps = 13/246 (5%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 108 +S+ + G LA A+ L++I+ K +T+SGH ++ ++W ++++L S S D Sbjct: 135 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRD 192 Query: 109 KTLKIWDVSSGKC-LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 + DV +T++ H+ V +N N + SG D V +++ + + T Sbjct: 193 HRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF 252 Query: 168 PAHSDPVSAVHFNRDGS-LIVSSS--YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224 H V A+ ++ ++ + D +IW+ + +K D + + +S Sbjct: 253 DEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS--IKMSDIDSGSQICNMVWSK 310 Query: 225 NGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 N ++ L LWD + + GH + + G +VSG+ D Sbjct: 311 NTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS---NDGTTVVSGAGDET 367 Query: 283 VYIWNL 288 + W L Sbjct: 368 LRYWKL 373 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 46/225 (20%), Positives = 92/225 (40%), Gaps = 10/225 (4%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDV 93 TL+GH V+ + + N L S S D I F +TI H + + Sbjct: 163 RKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGL 220 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGS--FD 150 W+ N L S +D + +++ +S + T H V ++P ++ +G D Sbjct: 221 KWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 280 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS--SSYDGLCRIWDTASGQCLKT 208 ++IW+V T + + + S + V ++++ + +V+ +WD S + Sbjct: 281 RRLKIWNVNTSIKMSDIDSGSQICNMV-WSKNTNELVTSHGYSKYNLTLWDCNSMDPIA- 338 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253 ++ + V + S +G +++ D TL+ W L +T Sbjct: 339 ILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNLFT 383 Score = 84.3 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 77/186 (41%), Gaps = 9/186 (4%) Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 +S+ + D TG + + +++ + GS + +GL I+D +C++TL Sbjct: 112 KSIFLTDNNTGDVVHLCDT-ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLS 170 Query: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS-KGKCLKTYTGHKNEKYCIFANFSVT 269 V+ + + N + + + D+ + D +T H E + N + Sbjct: 171 -GHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVA-- 225 Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN-IIASAALENDKTIK 328 + SG DN+V+++ +K + H V + A P + ++A+ D+ +K Sbjct: 226 -DNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLK 284 Query: 329 LWKSDC 334 +W + Sbjct: 285 IWNVNT 290 >5OV3-A nrPDB Length = 381 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 121/303 (39%), Gaps = 28/303 (9%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT 110 F+ G LA D I IW K IS H + + WS D + LVSAS D Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNI 90 Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNP--QSNLIVSGSFDESVRIWDVKTGKCLKTLP 168 + WDV SG C + + S + ++P Q+ ++V V + + + + Sbjct: 91 VSQWDVLSGDCDQRFRFPS-PILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVD 149 Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI----DDDNPPVSFVKFSP 224 SD F+R G I + + G + T S + + + + ++F+ Sbjct: 150 DDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFAR 209 Query: 225 NGKYILAATLDNTLKLWDYSK------------GKCLKTYTGHKNEKYCIFANFSVTGGK 272 G L T D ++++D + + L+ K C F+ G+ Sbjct: 210 KGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSG----DGE 265 Query: 273 WIVSGSE-DNLVYIWNLQTKEIVQKLQG-HTDVVISTACHPTENIIASAALENDKTIKLW 330 +IV+GS + +YIW +V+ L G ++++ A HP IIAS + + +W Sbjct: 266 YIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISS---GVVSIW 322 Query: 331 KSD 333 + Sbjct: 323 AQN 325 Score = 89.7 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 42/208 (20%), Positives = 82/208 (39%), Gaps = 14/208 (6%) Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 C FN L+ G D + IWD T K + AH PV ++ ++RDG +VS+S D Sbjct: 29 LTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTD 88 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 + WD SG C + P+ V++ P + + + + Sbjct: 89 NIVSQWDVLSGDCDQRFR--FPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVL 146 Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV-----VIST 307 + + A+F G++I +G+ + + ++++V + T + S Sbjct: 147 PVDDDSDLNVVASF-DRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSI 205 Query: 308 ACHPTEN--IIASAALENDKTIKLWKSD 333 + +I +A D+ I+++ Sbjct: 206 EFARKGSCFLINTA----DRIIRVYDGR 229 >4U1E-I nrPDB Length = 347 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 130/317 (41%), Gaps = 31/317 (9%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100 L GH + ++ VK++ G+ L S S D +W + +G+ T+ GH I + + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD-----ESVRI 155 V+ S D ++K+WDVS+G+C+ T K V F+P N ++ + S+ I Sbjct: 66 YCVTGSADYSIKLWDVSNGQCVATWKSPV-PVKRVEFSPCGNYFLAILDNVMKNPGSINI 124 Query: 156 WDVK-----------TGKCLKTLPAHS--DPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 ++++ + + + + H D + ++ G I++ DG +D ++ Sbjct: 125 YEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSN 184 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 ID +S ++FSP+ Y + ++ D L D S + LK Y + Sbjct: 185 NYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAV 244 Query: 263 FANFSV-------TGGKWIVSGSEDN---LVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 K + + S + ++ +E + ++QGH + + A P Sbjct: 245 ITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQ 304 Query: 313 ENIIASAALENDKTIKL 329 AS D I+L Sbjct: 305 GTSYASGG--EDGFIRL 319 Score = 110 bits (275), Expect = 9e-25, Method: Composition-based stats. Identities = 55/261 (21%), Positives = 114/261 (43%), Gaps = 25/261 (9%) Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 ++GH+ ++ V ++ + +LL S S D + +W +G+ L TL GH+ ++ + + + Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT 64 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD-----GLCR 196 V+GS D S+++WDV G+C+ T PV V F+ G+ ++ + G Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVAT-WKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSIN 123 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVK------------FSPNGKYILAATLDNTLKLWDYS 244 I++ L P+ + +S GKYI+A D + +D S Sbjct: 124 IYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 Query: 245 KG-KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303 + + + H+ + + ++ S D ++ ++ T ++++K + TD Sbjct: 184 NNYEYVDSIDLHEKSISDMQ---FSPDLTYFITSSRDTNSFLVDVSTLQVLKKYE--TDC 238 Query: 304 VISTAC-HPTENIIASAALEN 323 ++TA P + I + Sbjct: 239 PLNTAVITPLKEFIILGGGQE 259 Score = 92.0 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 43/287 (14%), Positives = 92/287 (32%), Gaps = 74/287 (25%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91 N TL GHT + S+ ++ + SAD IK+W +G+ T + + Sbjct: 39 SLNGERLGTLDGHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKS-PVPVK 97 Query: 92 DVAWSSDSNLLVSASDD-----KTLKIWDVS-----------SGKCLKTLKGHS--NYVF 133 V +S N ++ D+ ++ I+++ S + + + H + Sbjct: 98 RVEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAAT 157 Query: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTG-KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 ++ + I++G D + +DV + + ++ H +S + F+ D + ++SS D Sbjct: 158 VAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRD 217 Query: 193 --------GLCRIWDTASGQCLKTL----------------------------------- 209 ++ C Sbjct: 218 TNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARF 277 Query: 210 -----------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 + P++ V SP G + D ++L + K Sbjct: 278 YHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEK 324 Score = 57.7 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 23/154 (14%), Positives = 50/154 (32%), Gaps = 15/154 (9%) Query: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL 88 V NY ++ H K++S ++FSP+ + +SS D + + K Sbjct: 180 YDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYET-DC 238 Query: 89 GISDVAWSSDSNLLVSAS----DDKT----------LKIWDVSSGKCLKTLKGHSNYVFC 134 ++ + ++ D T + + + + ++GH + Sbjct: 239 PLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNT 298 Query: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP 168 +PQ SG D +R+ + Sbjct: 299 VAISPQGTSYASGGEDGFIRLHHFEKSYFDFKYD 332 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 7/35 (20%), Positives = 15/35 (42%), Gaps = 2/35 (5%) Query: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 KL GH + + +++ S + D + +W Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCS--KDSSASVW 37 >4BH6-A nrPDB Length = 308 Score = 168 bits (426), Expect = 2e-42, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 121/285 (42%), Gaps = 14/285 (4%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT 110 + +S + LA + K I + G + ++W + L + Sbjct: 29 IDWSST-DVLAVALG-KSIFLTDNNTGDVVHLCDTENEY-TSLSWIGAGSHLAVGQANGL 85 Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL-KTLPA 169 ++I+DV KC++TL GH + V C ++N ++++ SGS D + DV+ +T+ + Sbjct: 86 VEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRDHRILHRDVRMPDPFFETIES 143 Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 H+ V + +N + + S D + +++ S + T D+ V + +SP+ + + Sbjct: 144 HTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF-DEHKAAVKAMAWSPHKRGV 202 Query: 230 LA---ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 LA T D LK+W+ + +K + C T G + +W Sbjct: 203 LATGGGTADRRLKIWNVNT--SIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLW 260 Query: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + + + + L+GH+ V+ + S A D+T++ WK Sbjct: 261 DCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGA--GDETLRYWK 303 Score = 118 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 103/246 (41%), Gaps = 13/246 (5%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 108 +S+ + G LA A+ L++I+ K +T+SGH ++ ++W ++++L S S D Sbjct: 66 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRD 123 Query: 109 KTLKIWDVSSGKC-LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167 + DV +T++ H+ V +N N + SG D V +++ + + T Sbjct: 124 HRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF 183 Query: 168 PAHSDPVSAVHFNRDGS-LIVSSS--YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224 H V A+ ++ ++ + D +IW+ + +K D + + +S Sbjct: 184 DEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS--IKMSDIDSGSQICNMVWSK 241 Query: 225 NGKYILA--ATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 N ++ L LWD + + GH + + G +VSG+ D Sbjct: 242 NTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS---NDGTTVVSGAGDET 298 Query: 283 VYIWNL 288 + W L Sbjct: 299 LRYWKL 304 Score = 99.7 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 44/215 (20%), Positives = 89/215 (41%), Gaps = 10/215 (4%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDV 93 TL+GH V+ + + N L S S D I F +TI H + + Sbjct: 94 RKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGL 151 Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGS--FD 150 W+ N L S +D + +++ +S + T H V ++P ++ +G D Sbjct: 152 KWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTAD 211 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS--SSYDGLCRIWDTASGQCLKT 208 ++IW+V T + + + S + V ++++ + +V+ +WD S + Sbjct: 212 RRLKIWNVNTSIKMSDIDSGSQICNMV-WSKNTNELVTSHGYSKYNLTLWDCNSMDPIA- 269 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243 ++ + V + S +G +++ D TL+ W Sbjct: 270 ILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 82.7 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 77/186 (41%), Gaps = 9/186 (4%) Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 +S+ + D TG + + +++ + GS + +GL I+D +C++TL Sbjct: 43 KSIFLTDNNTGDVVHLCDT-ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLS 101 Query: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS-KGKCLKTYTGHKNEKYCIFANFSVT 269 V+ + + N + + + D+ + D +T H E + N + Sbjct: 102 -GHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVA-- 156 Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN-IIASAALENDKTIK 328 + SG DN+V+++ +K + H V + A P + ++A+ D+ +K Sbjct: 157 -DNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLK 215 Query: 329 LWKSDC 334 +W + Sbjct: 216 IWNVNT 221 Score = 30.4 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 19/36 (52%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD 76 L GH+ V + S +G + S + D+ ++ W +D Sbjct: 271 LKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 306 >6E29-D nrPDB Length = 345 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 58/324 (17%), Positives = 126/324 (38%), Gaps = 41/324 (12%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101 +GH+ + V+F+ G++LAS D + IW + + GH I+ ++WS Sbjct: 25 SGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRY 81 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWD--- 157 L+SA + +WD+ GK + ++ V+ +P + + F++ + D Sbjct: 82 LLSACQGWKVILWDLQDGKRYREVRF-RAPVYGAELHPWNHHQFAAALFEDQPMLVDITE 140 Query: 158 -VKTGKCLKTLPAHSDP------------------VSAVHFNRDGSLIVSSSYDGLCRIW 198 V+ L ++P + +A+ + G +++ + G I Sbjct: 141 PVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNII 200 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW------------DYSKG 246 D + + + + + ++ ++ + +G+ +L D ++ + D + Sbjct: 201 DARTREIIYSE-KIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQL 259 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 + N FS TG S ++ +YIW +V+ L+G + Sbjct: 260 PLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGV 319 Query: 307 TACHPTENIIASAALENDKTIKLW 330 HP ++A+ LE + I +W Sbjct: 320 IEWHPHRALLAACGLETGR-INIW 342 Score = 39.2 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 2/106 (1%) Query: 14 RAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKL-IKIW 72 R P+ SA P ++ KF + + + V FS GE++A+S+ + + IW Sbjct: 240 RTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIW 299 Query: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS-DDKTLKIWDVS 117 G + + G K + W LL + + + IW V+ Sbjct: 300 ERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 14/36 (38%), Gaps = 5/36 (13%) Query: 299 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 GH+ + + +AS D T+ +W + Sbjct: 26 GHS---TCVRFNRKGDFLASG--RVDGTVVIWDLET 56 >5OQL-X nrPDB Length = 630 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 118/301 (39%), Gaps = 44/301 (14%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97 T GH KA VK S +G+++ + ADK + ++ A D K K + H+ ++ +A+ Sbjct: 239 DKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRR 298 Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 +N L S S D+T+K+W + ++TL GH + + + Q + G+ D + R W Sbjct: 299 GTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWK 358 Query: 158 VKTGKCL---------------KTLPAHSDPVSAVH-------FNRDGSLIVSSSYDGLC 195 V L LP DP SA H D + V+ S +G Sbjct: 359 VPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDL 418 Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 +W + L + L+ +KL DYS + Sbjct: 419 ALWSIQRKKPLHVIARAH-------------------GLEPPIKLEDYSADEIPDPSIIP 459 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV-VISTACHPTEN 314 + I A ++ I SGS D + +W L E +KL+ + V S C + N Sbjct: 460 APQPRGITALRTLPYSDLIFSGSWDGCIRVWRLS--EDKRKLEAVGILGVGSETCENSTN 517 Query: 315 I 315 I Sbjct: 518 I 518 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 36/177 (20%), Positives = 61/177 (34%), Gaps = 20/177 (11%) Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW---DTASGQCLKTLIDDDNPP 216 +S V++V +++ DG W D Q +T P Sbjct: 159 DKATYTQFRWNSGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKP 216 Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 + K P A + KTY GH + A+ GK++V+ Sbjct: 217 PAPPKKRPERICFAKADA----------RKANDKTYQGHLKAPLVVKAS---QDGKFVVT 263 Query: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 G D + ++N + ++ H D V A N + S + D+T+K+W D Sbjct: 264 GGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCS--KDRTVKVWSLD 318 >4J0W-A nrPDB Length = 343 Score = 164 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 62/322 (19%), Positives = 126/322 (39%), Gaps = 27/322 (8%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--------- 83 P A L GH +++ + +P+ + S++ D I W G+ I Sbjct: 2 PEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEG 61 Query: 84 --SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 GH + +A SSD L S K + IW+ S + L T GH + V F + Sbjct: 62 KPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 + + S S D SV++W+V ++TL H D V+A+ + + DG R+W Sbjct: 122 HQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI- 180 Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK-TYTGHK---- 256 + + + + + N +++++ D ++ LW SK + L H Sbjct: 181 -PEESQLVFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGE 238 Query: 257 ---NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK----EIVQKLQGHTDVVISTAC 309 + + I + ++ + +GS + V +W +++ + + S Sbjct: 239 PGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL-VGFINSLKF 297 Query: 310 HPTENIIASAALENDKTIKLWK 331 + + + + + + + W+ Sbjct: 298 SSSGDFLVAGVGQEHRLGRWWR 319 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 118/289 (40%), Gaps = 15/289 (5%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYAL--KFTLAGHTKAVSSVKFSPNGEWLASSSADKL 68 AA+ S + V P + GH+ V + S +G++LAS KL Sbjct: 31 SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKL 90 Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 128 I IW A + T +GH+ +S +A+ ++ L S S D+++K+W+V+ ++TL GH Sbjct: 91 ILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGH 150 Query: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 + V + + + +G D +VR+W + L H + +H + +VS Sbjct: 151 QDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVS 208 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDN----------PPVSFVKFSPNGKYILAATLDNTL 238 + DG +W + + L + +S V N + + + + Sbjct: 209 GADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCV 268 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG-SEDNLVYIW 286 +LW +G I + + G ++V+G +++ + W Sbjct: 269 RLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 317 >1NR0-A nrPDB Length = 611 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 124/288 (43%), Gaps = 15/288 (5%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSSDSNL 101 H+ + K SP+G + AS ++IW + TI + D++W S+S Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 Query: 102 LVSASD--DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDV 158 + + + ++ ++ +G L G + + +F P I+SGS D +V I++ Sbjct: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD------ 212 K T H+ V +V +N DGSL S+ DG +++ G DD Sbjct: 178 PPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVA 237 Query: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT-GHKNEKYCIFANFSVTGG 271 + V + +SP+G I +A+ D T+K+W+ + K KT G + E + ++ Sbjct: 238 HSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTK--- 294 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319 + +VS S + + N + I Q GH + + + + SA Sbjct: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 69/353 (19%), Positives = 132/353 (37%), Gaps = 53/353 (15%) Query: 15 AQPTPSSSATQSKPTPV--KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72 ++P S + + P + K T HTK V SV+++P+G AS+ D I ++ Sbjct: 158 SRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLY 217 Query: 73 GAYDGKFEKTIS-------GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 DG H + + WS D + SAS DKT+KIW+V++ K KT+ Sbjct: 218 NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTI 277 Query: 126 KGHS---NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182 + + + Q+ +VS S + + + + G + H+ ++A+ + D Sbjct: 278 PVGTRIEDQQLGIIWTKQA--LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSAD 335 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW- 241 G + S+ +G WD ++G + D ++ +K + G + + D+ LK+ Sbjct: 336 GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGD-LFTVSWDDHLKVVP 394 Query: 242 -----------------------------DYSKGKCLKTYTGHKNEK-------YCIFAN 265 D + C K + + K Y Sbjct: 395 AGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCV 454 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTENIIA 317 +++ G +D+ V+++ L + K H + S A + Sbjct: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 123/377 (32%), Gaps = 93/377 (24%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS------------------ 84 H+ +V + +SP+G +AS+SADK IKIW K EKTI Sbjct: 237 AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA 296 Query: 85 -------------------------GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 119 GH I+ ++ S+D L SA + + WD+S+G Sbjct: 297 LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTG 356 Query: 120 KCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIW---------------------- 156 + H+ + + +L + S+D+ +++ Sbjct: 357 ISNRVFPDVHATMITGIKTTSKGDLF-TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPL 415 Query: 157 --------DVKTGKCLKTL----PAHSDPV------SAVHFNRDGSLIVSSSYDGLCRIW 198 D+ C K + V S V + D + D ++ Sbjct: 416 GLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTGHKN 257 + + ++ V FS NG +++A + + + + T + + Sbjct: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL--QGHT-DVVISTACHPTEN 314 ++S + + +GS DN V +WN+ + H V S Sbjct: 536 TAKVACVSWSPDNVR-LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETT 594 Query: 315 IIASAALENDKTIKLWK 331 I+++ D IK W Sbjct: 595 IVSAG---QDSNIKFWN 608 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 47/222 (21%), Positives = 81/222 (36%), Gaps = 22/222 (9%) Query: 124 TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK--TLPAHSDPVSAVHFNR 181 HS+ +P SG +VRIWD + T+P S PV + ++ Sbjct: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDS 113 Query: 182 DGSLIVSSSYD----GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY-ILAATLDN 236 + I + G ++DT + T ++ V F P+ + I++ + DN Sbjct: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGNLT---GQARAMNSVDFKPSRPFRIISGSDDN 170 Query: 237 TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK 296 T+ +++ K T+ H + + G S D + ++N Sbjct: 171 TVAIFEGPPFKFKSTFGEHTKF---VHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGV 227 Query: 297 LQ-------GHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + H+ V P IASA+ DKTIK+W Sbjct: 228 FEDDSLKNVAHSGSVFGLTWSPDGTKIASASA--DKTIKIWN 267 Score = 95.1 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 107/292 (36%), Gaps = 48/292 (16%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNL 101 GH KA++++ S +G+ L S+ A+ I W G + H I+ + +S + Sbjct: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGD- 380 Query: 102 LVSASDDKTLKIW------------------------------DVSSGKCLKTL----KG 127 L + S D LK+ D++ C K + G Sbjct: 381 LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHG 440 Query: 128 HSNYV------FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA--HSDPVSAVHF 179 V C + + G D V ++ + +G + + H +++V F Sbjct: 441 KLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAF 499 Query: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPNGKYILAATLDNT 237 + +G+ +V++ + A+ L V+ V +SP+ + +LDN+ Sbjct: 500 SNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNS 559 Query: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 + +W+ +K + + + + IVS +D+ + WN+ Sbjct: 560 VIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNVP 610 Score = 83.5 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 44/174 (25%), Positives = 64/174 (36%), Gaps = 11/174 (6%) Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDDNPPVSFVKF 222 + HS + + G S G RIWDT + LKT I + PV + + Sbjct: 52 TEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW 111 Query: 223 SPNGKYILAATLD----NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 K I A + L+D G TG + +F + I+SGS Sbjct: 112 DSESKRIAAVGEGRERFGHVFLFD--TGTSNGNLTGQARAMNSV--DFKPSRPFRIISGS 167 Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 +DN V I+ + HT V S +P ++ AS D TI L+ Sbjct: 168 DDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG--GDGTIVLYNG 219 >5WJC-A nrPDB Length = 430 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 122/284 (42%), Gaps = 42/284 (14%) Query: 86 HKLGISDVAWSSDSN-LLVSASDDKTLKIWD------VSSGKCL--KTLKGHSNYVFCCN 136 H ++ + ++ + + I+D +++G+ L LKGH+ F Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 137 FNPQ-SNLIVSGSFDESVRIWDVKTGK----------CLKTLPAHSDPVSAVHFNR-DGS 184 +NP + +G+ D+ + +WDV+T + H+D V+ V F+ + Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 185 LIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLW 241 L+ S S D +I DT + +I + ++ V +P Y+LA A+ D T+ LW Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 242 DYSKG-KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ----------- 289 D + L T GH++E Y + +S + S S D V IW+L+ Sbjct: 310 DLRNPYQRLHTLEGHEDEVYGLE--WSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDA 367 Query: 290 ---TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 + E++ GHT+ + + P E + +L +D +++W Sbjct: 368 EDGSPELLFMHGGHTNRISEFSWCPNERWVV-GSLADDNILQIW 410 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 116/287 (40%), Gaps = 44/287 (15%) Query: 44 HTKAVSSVKFSPN-GEWLASSSADKLIKIWG------AYDGK--FEKTISGHKLGISDVA 94 H V+ ++ P E +A+ I+ G+ + + GH + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 95 WSSD-SNLLVSASDDKTLKIWDVSSGK----------CLKTLKGHSNYVFCCNFNPQSN- 142 W+ + L + ++D+ + +WDV + + H++ V F+PQ Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 143 LIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIW 198 L+ S S D +++I D + + K + AHS ++AV N + L+ ++S D +W Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSK------------ 245 D + ++ V +++SP+ + + +++ D + +WD K Sbjct: 310 DLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAED 369 Query: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIV-SGSEDNLVYIWNLQ 289 + L + GH N +W+V S ++DN++ IW+ Sbjct: 370 GSPELLFMHGGHTNRISEFSWC---PNERWVVGSLADDNILQIWSPS 413 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 102/253 (40%), Gaps = 32/253 (12%) Query: 24 TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKT 82 T + L GHT + ++PN LA+ + D++I +W F + Sbjct: 161 TTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSS 220 Query: 83 ----------ISGHKLGISDVAWSSDSN-LLVSASDDKTLKIWDVS---SGKCLKTLKGH 128 H ++DV + LL S SDD TL+I D + K ++ H Sbjct: 221 ETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAH 280 Query: 129 SNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTG-KCLKTLPAHSDPVSAVHFNR-DGSL 185 S + NP L+ + S D++V +WD++ + L TL H D V + ++ D + Sbjct: 281 SKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPI 340 Query: 186 IVSSSYDGLCRIWDTASGQCLKT-------------LIDDDNPPVSFVKFSPNGKYIL-A 231 + SSS D IWD +T + +S + PN ++++ + Sbjct: 341 LASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGS 400 Query: 232 ATLDNTLKLWDYS 244 DN L++W S Sbjct: 401 LADDNILQIWSPS 413 >5OQL-d nrPDB Length = 446 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 125/304 (41%), Gaps = 24/304 (7%) Query: 43 GHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEK-TISGHKLGISDVAWSSDSN 100 GH + V S+ N +AS S D ++K+W E ++ H + + +++D Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKK 123 Query: 101 LLVSASDDKTLKIWD----VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 LL S + D +K+WD S+ + T + Y +F+ +N + S +RIW Sbjct: 124 LL-SCATDG-IKLWDPYASPSNTTPIATWQEGGPY-TSLSFHRSANTFAASSGQGCIRIW 180 Query: 157 DVKTGKCLKTL--PAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 D++ + + P+ D ++ V FN+ + S+I S + D ++D + + + Sbjct: 181 DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 214 NPPVSFVKFSPNGKY-ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 + + F+P + A+ D+ + ++D K K + G+ Sbjct: 241 --ACNRIVFNPMEAMNLAVASEDHNIYIFDARNFD--KALNIQKGHVAAVMDVEFSPTGE 296 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTD---VVISTACHPTENIIASAALENDKTIKL 329 +VSGS D + +W HT V T I + + +D ++L Sbjct: 297 ELVSGSYDRTIRLWRRDAGHSRDVY--HTKRMQRVFRTMWTMDSKYILTGS--DDGNVRL 352 Query: 330 WKSD 333 W+++ Sbjct: 353 WRAN 356 >4A11-B nrPDB Length = 408 Score = 157 bits (397), Expect = 6e-39, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 129/330 (39%), Gaps = 53/330 (16%) Query: 44 HTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTIS-------------GHKLG 89 H ++++ P G ++ S +D +I ++ + + + H+ Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 90 ISDVAW-SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN---LIV 145 + V W D+ + S+S DKTLK+WD ++ + V+ + +P S L+ Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNF-EETVYSHHMSPVSTKHCLVA 160 Query: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQ 204 G+ V++ D+K+G C L H + AV ++ ++ ++S D ++WD Sbjct: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS 220 Query: 205 -CLKTLIDD--------------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 CL TL N V+ + F+ +G ++L DN ++LW+ S G+ Sbjct: 221 GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT 280 Query: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSED---------NLVYIWNLQTKEIVQKLQGH 300 G N S G K+ VS + + ++ + + E + L+GH Sbjct: 281 LVNYG-------KVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 Query: 301 TDVVISTACHPTENIIASAALENDKTIKLW 330 V + S + D I W Sbjct: 334 YKTVDCCVFQSNFQELYSGS--RDCNILAW 361 Score = 88.5 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 40/189 (21%), Positives = 79/189 (41%), Gaps = 30/189 (15%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY------------DGKFEKT 82 + L GH + + +V +SP ++ LA++SAD +K+W +GK + Sbjct: 177 SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQA 236 Query: 83 ISG----HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK---------CLKTLKGHS 129 + H ++ + ++SD L++ D +++W+ S+G+ C + KG Sbjct: 237 VESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLK 296 Query: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 V C S+ V + ++ ++ V +G+ + L H V F + + S Sbjct: 297 FTVSC----GCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSG 352 Query: 190 SYDGLCRIW 198 S D W Sbjct: 353 SRDCNILAW 361 Score = 70.0 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 56/130 (43%), Gaps = 5/130 (3%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG--HKLG 89 K + A++ H V+ + F+ +G L + D +++W + +G+ G Sbjct: 232 KKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNS 291 Query: 90 ISDVAWS---SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146 + ++ S+ V T+ ++ V SG+ + LKGH V CC F + S Sbjct: 292 KKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYS 351 Query: 147 GSFDESVRIW 156 GS D ++ W Sbjct: 352 GSRDCNILAW 361 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 20/123 (16%), Positives = 41/123 (33%), Gaps = 34/123 (27%) Query: 213 DNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 ++ + P G+Y+L+ D + L+D YT Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTC----------------- 84 Query: 272 KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 K + S D+ H V + +P + + +++ DKT+K+W Sbjct: 85 KAVCSIGRDH---------------PDVHRYSVETVQWYPHDTGMFTSSSF-DKTLKVWD 128 Query: 332 SDC 334 ++ Sbjct: 129 TNT 131 >3C9C-A nrPDB Length = 432 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 120/285 (42%), Gaps = 41/285 (14%) Query: 43 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY----------DGKFEKTISGHKLGIS 91 H V+ ++ P N +A+ + + ++ + + + + GH+ Sbjct: 128 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 92 DVAWSSDSN-LLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNP-QSN 142 ++W+ + N L+SASDD T+ +WD+++ GH+ V ++ + Sbjct: 188 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 143 LIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSYDGLCRIW 198 L S + D+ + IWD + T K T+ AH+ V+ + FN I + S D +W Sbjct: 248 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 307 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK------------ 245 D + + + + V++SP+ + ILA++ D L +WD SK Sbjct: 308 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 367 Query: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 + L + GH + ++ I S SEDN++ +W + Sbjct: 368 GPPELLFIHGGHTAKISDFS--WNPNEPWIICSVSEDNIMQVWQM 410 Score = 140 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 64/250 (25%), Positives = 110/250 (44%), Gaps = 30/250 (12%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKT-- 82 SKP P L GH K + ++PN +L S+S D I +W E Sbjct: 165 SKPEPSG-ECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVI 223 Query: 83 -----ISGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDV---SSGKCLKTLKGHSNYVF 133 +GH + DVAW L S +DD+ L IWD ++ K T+ H+ V Sbjct: 224 DAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVN 283 Query: 134 CCNFNPQSNL-IVSGSFDESVRIWDVKTGKC-LKTLPAHSDPVSAVHFNR-DGSLIVSSS 190 C +FNP S + +GS D++V +WD++ K L + +H D + V ++ + +++ SS Sbjct: 284 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 343 Query: 191 YDGLCRIWDTAS-------------GQCLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDN 236 D +WD + L + +S ++PN +I+ + + DN Sbjct: 344 TDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDN 403 Query: 237 TLKLWDYSKG 246 +++W ++ Sbjct: 404 IMQVWQMAEN 413 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 117/284 (41%), Gaps = 41/284 (14%) Query: 86 HKLGISDVAWSS-DSNLLVSASDDKTLKIWDVS--------SGKCLK--TLKGHSNYVFC 134 H+ ++ + ++ ++ + + + ++D + SG+C L+GH + Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 135 CNFNPQ-SNLIVSGSFDESVRIWDV-------KTGKCLKTLPAHSDPVSAVHFNR-DGSL 185 ++NP + ++S S D ++ +WD+ + H+ V V ++ SL Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 186 IVSSSYDGLCRIWDTASG--QCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWD 242 S + D IWDT + +D V+ + F+P ++ILA + D T+ LWD Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 243 YSKGKC-LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT----------- 290 K L ++ HK+E +S + S D +++W+L Sbjct: 309 LRNLKLKLHSFESHKDEI--FQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAE 366 Query: 291 ---KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 E++ GHT + + +P E I ++ D +++W+ Sbjct: 367 DGPPELLFIHGGHTAKISDFSWNPNEPWII-CSVSEDNIMQVWQ 409 Score = 58.1 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 25/148 (16%), Positives = 63/148 (42%), Gaps = 19/148 (12%) Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSK--------GKCLKTYT 253 G+ + + V+ ++ P ++A T + + ++DY+K G+C Sbjct: 119 GKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLR 178 Query: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK-------EIVQKLQGHTDVVIS 306 ++K +++ +++S S+D+ + +W++ + GHT VV Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 307 TACH-PTENIIASAALENDKTIKLWKSD 333 A H E++ ++ +D+ + +W + Sbjct: 239 VAWHLLHESLF--GSVADDQKLMIWDTR 264 >6ELZ-p nrPDB Length = 460 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 129/318 (40%), Gaps = 45/318 (14%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 + VSS+ + + S S D +++ W G +K SGH I V + S++ LV Sbjct: 102 NEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTR-LV 159 Query: 104 SASDDKTLKIW-----------------------DVSSGKCLKTLKGHSNYVFCCNFNPQ 140 SA +D+TL++W ++ GK L L+GH V + + Sbjct: 160 SAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDN 219 Query: 141 SNLIVSGSFDESVRIWDV--KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198 S ++ S S+D S+ W K + L ++P + + ++ DG R Sbjct: 220 SRIL-SASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM-KDGTIR-- 275 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYI-LAATLDNTLKLWDYSKGKCLKTYTGHKN 257 + +L++ PV V F + + + D+T+K WD +C+ T T Sbjct: 276 ----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRT---- 327 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ----TKEIVQKLQGHTDVVISTACHPTE 313 Y + + ++ + GS + + + + +K Q+L GH + V S P Sbjct: 328 TSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPEN 387 Query: 314 NIIASAALENDKTIKLWK 331 I + +D T+K+W Sbjct: 388 EYI-LCSGSHDGTVKVWD 404 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 54/251 (21%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG--------------------------- 73 L GH V S+ S + + S+S D I W Sbjct: 204 LEGHKAPVVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAAR 262 Query: 74 ------AYDGKFEKT-----ISGHKLGISDVAWSSDSNLL-VSASDDKTLKIWDVSSGKC 121 DG + + H + V + S N + S S D T+K WD+ + +C Sbjct: 263 KRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARC 322 Query: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL----KTLPAHSDPVSAV 177 + T S + NL+ GS + + D + G + L H + VS++ Sbjct: 323 IDTRTT-SYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSL 381 Query: 178 HFNRDGSLI-VSSSYDGLCRIWDTASGQCLKTLIDDD-------NPPVSFVKFSPNGKYI 229 + I S S+DG ++WD S + T+ +D N V VK++ I Sbjct: 382 DTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWA-EKVGI 440 Query: 230 LAATLDNTLKL 240 ++A D +++ Sbjct: 441 ISAGQDKKIQI 451 Score = 63.1 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 29/144 (20%), Positives = 52/144 (36%), Gaps = 31/144 (21%) Query: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 271 + VS + K+I++ + D ++ WD S G K Y+GH + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLS-GNVQKQYSGHSGPIRAV----KYISN 155 Query: 272 KWIVSGSEDNLVYIW-----------------------NLQTKEIVQKLQGHTDVVISTA 308 +VS D + +W N++ + + L+GH V+S Sbjct: 156 TRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSID 215 Query: 309 CHPTENIIASAALENDKTIKLWKS 332 + I SA+ D +I W + Sbjct: 216 VS-DNSRILSASY--DNSIGFWST 236 >5Y1U-A nrPDB Length = 456 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 121/285 (42%), Gaps = 41/285 (14%) Query: 43 GHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAY----------DGKFEKTISGHKLGIS 91 H V+ ++ P +A+ + + ++ + + + GH+ Sbjct: 153 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 212 Query: 92 DVAWSSD-SNLLVSASDDKTLKIWDVS----SGKCL---KTLKGHSNYVFCCNFNP-QSN 142 ++W+ + S L+SASDD T+ +WD+S GK + GH+ V +++ + Sbjct: 213 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 272 Query: 143 LIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSYDGLCRIW 198 L S + D+ + IWD + T K ++ AH+ V+ + FN I + S D +W Sbjct: 273 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 332 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK------------ 245 D + + + + V++SP+ + ILA++ D L +WD SK Sbjct: 333 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 392 Query: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 + L + GH + ++ I S SEDN++ +W + Sbjct: 393 GPPELLFIHGGHTAKISDFS--WNPNEPWVICSVSEDNIMQVWQM 435 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 126/301 (41%), Gaps = 46/301 (15%) Query: 72 WGAYDGKFEKTIS-GHKLGISDVAWSSDSNLLV---SASDDKTLKIWDVS--------SG 119 +G+ GK E I H+ ++ + + ++ + S D + ++D + SG Sbjct: 139 FGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSD--VLVFDYTKHPSKPDPSG 196 Query: 120 KCLK--TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIWDV----KTGKCL---KTLPA 169 +C L+GH + ++NP S ++S S D ++ +WD+ K GK + Sbjct: 197 ECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 256 Query: 170 HSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASG--QCLKTLIDDDNPPVSFVKFSPNG 226 H+ V V ++ SL S + D IWDT S +D V+ + F+P Sbjct: 257 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 316 Query: 227 KYILA-ATLDNTLKLWDYSKGKC-LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284 ++ILA + D T+ LWD K L ++ HK+E +S + S D + Sbjct: 317 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEI--FQVQWSPHNETILASSGTDRRLN 374 Query: 285 IWNLQT--------------KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 +W+L E++ GHT + + +P E + ++ D +++W Sbjct: 375 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI-CSVSEDNIMQVW 433 Query: 331 K 331 + Sbjct: 434 Q 434 Score = 103 bits (258), Expect = 7e-23, Method: Composition-based stats. Identities = 38/185 (20%), Positives = 76/185 (41%), Gaps = 22/185 (11%) Query: 41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY---DGKFEKTISGHKLGISDVAWS 96 GHT V V + + S + D+ + IW K ++ H ++ ++++ Sbjct: 254 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 313 Query: 97 SDSN-LLVSASDDKTLKIWDVSSGK-CLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESV 153 S +L + S DKT+ +WD+ + K L + + H + +F ++P ++ S D + Sbjct: 314 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 373 Query: 154 RIWDVKT--------------GKCLKTLPAHSDPVSAVHFNRDGSL-IVSSSYDGLCRIW 198 +WD+ + L H+ +S +N + I S S D + ++W Sbjct: 374 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Query: 199 DTASG 203 A Sbjct: 434 QMAEN 438 Score = 92.0 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 41/169 (24%), Positives = 72/169 (42%), Gaps = 27/169 (15%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLI 69 + + + S SKP+ ++ HT V+ + F+P E+ LA+ SADK + Sbjct: 279 DDQKLMIWDTRSNNTSKPS---------HSVDAHTAEVNCLSFNPYSEFILATGSADKTV 329 Query: 70 KIWGAYDGKF-EKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSS--------- 118 +W + K + HK I V WS + +L S+ D+ L +WD+S Sbjct: 330 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 389 Query: 119 -----GKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTG 161 + L GH+ + ++NP +I S S D +++W + Sbjct: 390 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 438 >5WYJ-BE nrPDB Length = 939 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 112/260 (43%), Gaps = 9/260 (3%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK 81 + T + T G V SV S G + S++ I I+ G K Sbjct: 440 ARTWDMRNKRVGRWTFDTTDDG---FVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRK 496 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 HK ++ ++ + +VS D + +D + L LK + ++ S Sbjct: 497 KYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL-DAPITAMVYHRSS 555 Query: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201 +L D S+ + D T + ++ L HS+ ++A F+ +G IVS+S D R WD Sbjct: 556 DLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLP 615 Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNTLKLW-DYSKGKCLKTYTGHKNE- 258 +G C+ +I D+ + VKFSPNG + N + +W + ++ K + T T ++E Sbjct: 616 TGGCIDGIIVDNVA--TNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEF 673 Query: 259 KYCIFANFSVTGGKWIVSGS 278 + SV G ++SG+ Sbjct: 674 ARMALPSTSVRGNDSMLSGA 693 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 65/350 (18%), Positives = 132/350 (37%), Gaps = 40/350 (11%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLI 69 + + S + S V+P L + GH++ S + F ++ S+S D+ Sbjct: 317 NSLKEYVFDPSLSQGSGDVVVQPPRYL-RSRGGHSQPPSYIAFADSQSHFMLSASKDRS- 374 Query: 70 KIWGAY----------DGKFEKTISGHKLGISDV--------------AWSSDSNLLVSA 105 +W + K G ++G S + A + +++A Sbjct: 375 -LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITA 433 Query: 106 SDD-KTLKIWDVSSGKCLKTLKGHS---NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161 D K + WD+ + K + + +V + N GS + S+ I+++++G Sbjct: 434 HKDEKFARTWDMRN-KRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSG 492 Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221 K H V+ + + +VS DG+ +D L L D P++ + Sbjct: 493 ILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLD--APITAMV 550 Query: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 + + A D ++ + D + ++ GH N I A G+WIVS S D+ Sbjct: 551 YHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNR---ITAFDFSPEGRWIVSASLDS 607 Query: 282 LVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + W+L T + + +V + P +++A+ + + +W Sbjct: 608 TIRTWDLPTGGCIDGIIV-DNVATNVKFSPNGDLLATTHVTGNGIC-IWT 655 Score = 98.9 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 57/325 (17%), Positives = 119/325 (36%), Gaps = 46/325 (14%) Query: 46 KAVSSVKFSPNGEWLASSSADKLIK--IWG-----------AYDGKFEKTISGHKLGISD 92 V+ F + +S D +K ++ ++ ++ GH S Sbjct: 296 GGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSY 355 Query: 93 VAW-SSDSNLLVSASDDKTLKIW----DVSSGKCLKTLKGHSN----------------- 130 +A+ S S+ ++SAS D++L + D S + + L + Sbjct: 356 IAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIV 415 Query: 131 --YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-TLPA-HSDPVSAVHFNRDGSLI 186 + N+I + ++ R WD++ + + T V +V ++ G+ Sbjct: 416 ALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFG 475 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG 246 S +G I++ SG L+ V+ + + +++ LD + +D++K Sbjct: 476 FIGSSNGSITIYNMQSG-ILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKS 534 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 L I A +D + + + T+ +V++L GH++ + + Sbjct: 535 TLLGKLKLDAP----ITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITA 590 Query: 307 TACHPTENIIASAALENDKTIKLWK 331 P I SA+L D TI+ W Sbjct: 591 FDFSPEGRWIVSASL--DSTIRTWD 613 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 51/275 (18%), Positives = 111/275 (40%), Gaps = 38/275 (13%) Query: 57 GEWLASSSADKLIKIW------GAYDGKFEKTISG---HKLGISDVA-WSSDSNLLVSAS 106 G++L +S+ D I I+ Y +F ++ I + ++ N L + Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVT 184 Query: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKT 166 + +++V +GK + T + + P ++I G+ V +++++ GK ++T Sbjct: 185 KSN-VLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRT 243 Query: 167 LPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP---VSFVKF 222 + +S++ F DG S + + G +D + L + V+ F Sbjct: 244 IKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATF 303 Query: 223 SPNGKYILAATLDNTLK--LWD-----------YSKGKCLKTYTGHKNEKYCIFANFSVT 269 I+ + DN+LK ++D + L++ GH I F+ + Sbjct: 304 LNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYI--AFADS 361 Query: 270 GGKWIVSGSEDNLVYIW------NLQTKEIVQKLQ 298 +++S S+D + W + Q++E+ Q+L Sbjct: 362 QSHFMLSASKDRSL--WSFSLRKDAQSQEMSQRLH 394 Score = 62.3 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 96/259 (37%), Gaps = 34/259 (13%) Query: 99 SNLLVSASDDKTLKIWDVSSGK-----------CLKTLKGHSNYVFCCNFNPQSNLIVSG 147 + L +++DD ++ I+ S + + ++G V + N + Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQG-GEIVSLQHLATYLNKLTVV 183 Query: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 + V +++V+TGK + T D ++ +I + G +++ G+ ++ Sbjct: 184 TKSN-VLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIR 242 Query: 208 TLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSKGKCLKTYT-GHKNEKYCIFAN 265 T I +S + F +G ++ T L +D + + H+ + Sbjct: 243 T-IKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQA 301 Query: 266 FSVTGGKWIVSGSEDNLV--YIWN-----------LQTKEIVQKLQGHTDVVISTAC-HP 311 + G IV+ DN + Y+++ +Q ++ GH+ A Sbjct: 302 TFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADS 361 Query: 312 TENIIASAALENDKTIKLW 330 + + SA+ D++ LW Sbjct: 362 QSHFMLSAS--KDRS--LW 376 >3CFV-B nrPDB Length = 414 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 119/285 (41%), Gaps = 41/285 (14%) Query: 43 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY----------DGKFEKTISGHKLGIS 91 H V+ ++ P N +A+ + + ++ + + + GH+ Sbjct: 124 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 183 Query: 92 DVAWSSD-SNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCNFNP-QSN 142 ++W+S+ S L+SASDD T+ +WD+++G GHS V ++ + Sbjct: 184 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 243 Query: 143 LIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNRDGSLI-VSSSYDGLCRIW 198 L S + D+ + IWD + T K + AH+ V+ + FN I + S D +W Sbjct: 244 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 303 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT-LDNTLKLWDYSK------------ 245 D + + + + V +SP+ + ILA++ D L +WD SK Sbjct: 304 DLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAED 363 Query: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288 + L + GH + ++ I S SEDN++ IW + Sbjct: 364 GPPELLFIHGGHTAKISDFS--WNPNEPWVICSVSEDNIMQIWQM 406 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 118/284 (41%), Gaps = 41/284 (14%) Query: 86 HKLGISDVAWSS-DSNLLVSASDDKTLKIWDVS--------SGKCL--KTLKGHSNYVFC 134 H+ ++ + + +++ + + + ++D + SG+C L+GH + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 135 CNFNPQ-SNLIVSGSFDESVRIWDVKTG-------KCLKTLPAHSDPVSAVHFNR-DGSL 185 ++N S ++S S D +V +WD+ G HS V V ++ SL Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 186 IVSSSYDGLCRIWDTASG--QCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWD 242 S + D IWDT S L+D V+ + F+P ++ILA + D T+ LWD Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 304 Query: 243 YSKGKC-LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT----------- 290 K L T+ HK+E + + +S + S D + +W+L Sbjct: 305 LRNLKLKLHTFESHKDEIFQVH--WSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 291 ---KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 E++ GHT + + +P E + ++ D +++W+ Sbjct: 363 DGPPELLFIHGGHTAKISDFSWNPNEPWVI-CSVSEDNIMQIWQ 405 Score = 103 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 40/188 (21%), Positives = 77/188 (40%), Gaps = 22/188 (11%) Query: 38 KFTLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGA---YDGKFEKTISGHKLGISDV 93 K GH+ V V + + S + D+ + IW K + H ++ + Sbjct: 222 KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 281 Query: 94 AWSSDSN-LLVSASDDKTLKIWDVSSGK-CLKTLKGHSNYVFCCNFNP-QSNLIVSGSFD 150 +++ S +L + S DKT+ +WD+ + K L T + H + +F +++P ++ S D Sbjct: 282 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 341 Query: 151 ESVRIWDVKT--------------GKCLKTLPAHSDPVSAVHFNRDGSL-IVSSSYDGLC 195 + +WD+ + L H+ +S +N + I S S D + Sbjct: 342 RRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 401 Query: 196 RIWDTASG 203 +IW A Sbjct: 402 QIWQMAEN 409 Score = 93.1 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 27/169 (15%) Query: 11 EAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLI 69 + + + S T SKP+ + + HT V+ + F+P E+ LA+ SADK + Sbjct: 250 DDQKLMIWDTRSNTTSKPSHL---------VDAHTAEVNCLSFNPYSEFILATGSADKTV 300 Query: 70 KIWGAYDGKF-EKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSS--------- 118 +W + K T HK I V WS + +L S+ D+ L +WD+S Sbjct: 301 ALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAED 360 Query: 119 -----GKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTG 161 + L GH+ + ++NP +I S S D ++IW + Sbjct: 361 AEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 409 Score = 57.3 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 34/180 (18%), Positives = 76/180 (42%), Gaps = 22/180 (12%) Query: 174 VSAVHFNRDGSLIVSSSYD---GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 V+ VH D + +S D G + + +G+ + + V+ ++ P +I+ Sbjct: 83 VARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHII 142 Query: 231 AA-TLDNTLKLWDYSK--------GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 281 A T + + ++DY+K G+C ++K +++ ++S S+D+ Sbjct: 143 ATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDH 202 Query: 282 LVYIWNLQTKEIVQK-------LQGHTDVVISTACH-PTENIIASAALENDKTIKLWKSD 333 V +W++ K GH+ VV A H E++ ++ +D+ + +W + Sbjct: 203 TVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLF--GSVADDQKLMIWDTR 260 >3JRO-A nrPDB Length = 753 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVHFNR-- 181 H+ + + + + S D++++I++V+ T K + TL H PV V + Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTL 238 G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ D + Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG------------GKWIVSGSEDNLVYIW 286 + ++ + + A+++ + V+G DNLV IW Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 287 ----NLQTKEIVQKLQGHTDVVISTACHPTENIIA-SAALENDKTIKLWKSD 333 + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 105/275 (38%), Gaps = 31/275 (11%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFEKTISGHKLGISDVAWSSD-- 98 H + + G+ LA+ S+DK IKI+ K T++GH+ + V W+ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 99 SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNP--QSNLIVSGSFDESVR 154 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 155 IWDVKTGKCLK--TLPAHSDPVSAVHFNR-----DGSL--------IVSSSYDGLCRIWD 199 + + K + AH+ V++ + DG V+ D L +IW Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 200 TASG---QCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLKT 251 S L++ ++ + V V +SP Y+ + + D T +W D +G KT Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 + ++ G + DN V +W Sbjct: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 114/281 (40%), Gaps = 33/281 (11%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNF-NPQ 140 + H I D L + S DKT+KI++V + K + TL GH V+ ++ +P+ Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 141 -SNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLC 195 ++ S S+D V IW + G + HS V++V + G L++ +S DG Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 196 RIWDTA-SGQCLKTLIDDDNPPVSFVKFSP-------------NGKYILAATLDNTLKLW 241 + + +G +ID V+ ++P + + DN +K+W Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 242 ----DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW--NLQTKEIVQ 295 D T GH + + + +V ++ S S+D IW + + + Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 Query: 296 KLQGHT---DVVISTACHPTENIIASAALENDKTIKLWKSD 333 L DV+ + + N++A + D + LWK + Sbjct: 246 TLLKEEKFPDVLWRASWSLSGNVLALSG--GDNKVTLWKEN 284 Score = 123 bits (309), Expect = 9e-29, Method: Composition-based stats. Identities = 63/239 (26%), Positives = 99/239 (41%), Gaps = 32/239 (13%) Query: 35 YALKFTLAGHTKAVSSVKF-SPN-GEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGI 90 + L TL GH V V + P G LAS S D + IW +G++ + + H + Sbjct: 43 HKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASV 102 Query: 91 SDVAWSS--DSNLLVSASDDKTLKI--WDVSSGKCLKTLKGHSNYVFCCNFNP------- 139 + V W+ LL+ AS D + + + + + H+ V ++ P Sbjct: 103 NSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 Query: 140 ------QSNLIVSGSFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFNRD---GSLI 186 +S V+G D V+IW D +T TL HSD V V ++ S + Sbjct: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 Query: 187 VSSSYDGLCRIW--DTASGQCLKTLIDDDNPP--VSFVKFSPNGKYILAATLDNTLKLW 241 S S D C IW D G KTL+ ++ P + +S +G + + DN + LW Sbjct: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 41/112 (36%), Gaps = 5/112 (4%) Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY--SKGKCLKTYTGHKNEKYCIF 263 + + + N + GK + + D T+K+++ K + T TGH+ + + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKE--IVQKLQGHTDVVISTACHPTE 313 G + S S D V IW + + H+ V S P E Sbjct: 61 -WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 >5OQL-L nrPDB Length = 557 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 128/275 (46%), Gaps = 15/275 (5%) Query: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-- 78 ++ + + ++ LK T+ + P+G L + ++++ G Sbjct: 76 TAGPRVEIFSIRKREPLK-TIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRA 134 Query: 79 -FEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136 KT HK + WS + L+S SDDKT+++WD+ S + GH++YV C Sbjct: 135 VILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGA 194 Query: 137 FNP---QSNLIVSGSFDESVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 F P SNL+VSGS+DE+VR+WD + G + T H+DP+ V G+ ++++S + Sbjct: 195 FMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTF-KHADPIEDVLPLPSGTTLLAASGN 253 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL--K 250 + D + + L+ LI + V+ + + G+ +++ +LD +K+++ + + Sbjct: 254 A-ISVLDLVAAKPLR-LITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGA 311 Query: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285 Y I A S + + G + ++ I Sbjct: 312 KYPSPILSLSVITAGAS-HDDRHLAVGMQSGVLSI 345 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 122/282 (43%), Gaps = 29/282 (10%) Query: 60 LASSSADKLIKIWGAYDGKFEKTI-----SGHKLGISDVAWSSDSNLLVSASDDKTLKIW 114 L + +A ++I+ + KTI H I D +LV+ D ++++ Sbjct: 72 LFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIR-----PDGRVLVAGEDTGRMQVF 126 Query: 115 DVSSGKC---LKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAH 170 DV G LKT H V+ ++P ++S S D++VR+WD+ + + H Sbjct: 127 DVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGH 186 Query: 171 SDPVSAVHFNR---DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227 +D V F + +L+VS SYD R+WD + P+ V P+G Sbjct: 187 TDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPSGT 245 Query: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 +LAA+ N + + D K L+ T H+ + + G+ +VSGS D V ++ Sbjct: 246 TLLAAS-GNAISVLDLVAAKPLRLITNHQKTVTSLSLA---SQGRRVVSGSLDGHVKVFE 301 Query: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 + +V + + ++S + +I + A +D+ + + Sbjct: 302 TTSWNVVAGAKYPS-PILSLS------VITAGASHDDRHLAV 336 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 48/239 (20%), Positives = 99/239 (41%), Gaps = 16/239 (6%) Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161 L + + ++I+ + + LKT+ + C P ++V+G ++++DV G Sbjct: 72 LFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQG 131 Query: 162 K---CLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 LKT H PV ++ + ++S S D R+WD S + L V Sbjct: 132 TRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTR-LFTGHTDYV 190 Query: 218 SFVKFSP---NGKYILAATLDNTLKLWDYS-KGKCLKTYTGHKNEKYCIFANFSVTGGKW 273 F P N +++ + D T+++WD G + T+ H + + S G Sbjct: 191 RCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVLPLPS--GTTL 247 Query: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 + + N + + +L + ++ + H V S + + S +L D +K++++ Sbjct: 248 LAASG--NAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSL--DGHVKVFET 302 >1PI6-A nrPDB Length = 615 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 126/331 (38%), Gaps = 39/331 (11%) Query: 25 QSKPTPVKPNYALKFTLAGH-TKAVSSVKFSP--NGEWLASSSADKLIKIW--------G 73 SK PV GH + V++VKFSP ++L S + +W Sbjct: 50 DSKVPPV-------VQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 Query: 74 AYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD----KTLKIWDVSSGKCLKTLKGHS 129 + + + ISD++W + L + WD SG L + GHS Sbjct: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHS 160 Query: 130 NYVFCCNFNPQSNL-IVSGSFDESVRIWD---VKTGKCLKTLPAHSDPVSAVHFNRD-GS 184 + C+ + ++ D SV + K +T V V F+ D G Sbjct: 161 QRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGE 220 Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNP---PVSFVKFSPNGKYILAATLDNTLKLW 241 +++ D +D SG+ LK + DD P + + + + K D T+++W Sbjct: 221 FVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK-FATVGADATIRVW 279 Query: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301 D + KC++ +T K + TG I+S S D + + L E+++ + GH Sbjct: 280 DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHN 339 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWKS 332 + + +P + S + D I W S Sbjct: 340 KGITALTVNP----LISGSY--DGRIMEWSS 364 Score = 89.3 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 75/450 (16%), Positives = 141/450 (31%), Gaps = 142/450 (31%) Query: 16 QPTPSSSATQSKPTPV----KPNYALKFTLAGHTKA---VSSVKFSPN-GEWLASSSADK 67 Q P S T V P + + H K V V+FSP+ GE++ + +D+ Sbjct: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR 229 Query: 68 LIKIWGAYDGKFEKTISGHKLGISD----VAWSSDSNLLVSASDDKTLKIWDVSSGKC-- 121 I + G+F K I + + ++W DS + D T+++WDV++ KC Sbjct: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQ 288 Query: 122 -------------------------------------------LKTLKGHSNYVFCCNFN 138 LKT+ GH+ + N Sbjct: 289 KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN 348 Query: 139 PQSNLIVSGSFDESVRIWDVKTGKCLK-----------------TLPAHSDPVSAVHFNR 181 P ++SGS+D + W + + V+ + + Sbjct: 349 P----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 Query: 182 DGSL--IVSSSYDG---------------------------------------------- 193 GS + S++ DG Sbjct: 405 FGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLE 464 Query: 194 ---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLK 250 +++ + + L S++ SP+ YI A + + L+D + Sbjct: 465 EGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKT 524 Query: 251 TYTGHKNEKYCIFANFSVTGG--------KWIVSGSEDNLVYIWNL-QTKEIVQKLQGHT 301 + + K + G + +GS D ++I+++ + +I++ L H Sbjct: 525 SRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHK 584 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWK 331 D V + +++S A D IK W Sbjct: 585 DGVNNLLWETPSTLVSSGA---DACIKRWN 611 Score = 59.6 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 27/205 (13%), Positives = 76/205 (37%), Gaps = 24/205 (11%) Query: 60 LASSSADK-LIKIWGAYDGKFEKTISGHKLGISDVAWSSDS-------NLLVSASDDK-T 110 +AS++ D + D ++ +G I V +S N + ++ T Sbjct: 411 VASANNDGFTAVLTNDDDLLILQSFTG--DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNT 468 Query: 111 LKIWDVSSGKCLKTLKGHSNYVFC-CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169 ++++ +S + LK + +P I +G + ++D+++ + + A Sbjct: 469 IQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 Query: 170 H-SDPVSAVHFNR----------DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 + ++A+ + + L+ + S D I+ + ++ V+ Sbjct: 529 FRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 Query: 219 FVKFSPNGKYILAATLDNTLKLWDY 243 + + ++++ D +K W+ Sbjct: 589 NLLW-ETPSTLVSSGADACIKRWNV 612 Score = 53.1 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 60/144 (41%), Gaps = 16/144 (11%) Query: 27 KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT-ISG 85 K + ++ ++ LK L + SP+ ++A+ I ++ + + + + Sbjct: 473 KLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILLYDLQSREVKTSRWAF 529 Query: 86 HKLGISDVAWSS----------DSNLLVSASDDKTLKIWDV-SSGKCLKTLKGHSNYVFC 134 I+ ++W + +L+ + S D + I+ V K +K L H + V Sbjct: 530 RTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNN 589 Query: 135 CNFNPQSNLIVSGSFDESVRIWDV 158 + S L+ SG+ D ++ W+V Sbjct: 590 LLWETPSTLVSSGA-DACIKRWNV 612 >4XYI-A nrPDB Length = 430 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 123/284 (43%), Gaps = 42/284 (14%) Query: 86 HKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKT--------LKGHSNYVFCCN 136 H+ ++ + + +++ + + I+D++ + L+ H++ F Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 137 FNP-QSNLIVSGSFDESVRIWDVKTGK----------CLKTLPAHSDPVSAVHFN-RDGS 184 +N Q + +G+ D S+ +WD+K + H+ V+ + F+ + + Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 185 LIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLW 241 L+ S S D +I DT S + PV+ V F+P Y+LA A+ D+T+ LW Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 242 DYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ----------- 289 D + + L T GH++E Y + +S +V+ S D V +W+L Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQ--WSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDS 367 Query: 290 ---TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 E++ GHT+ V + +P + A+L +D +++W Sbjct: 368 EDGAPELMFMHGGHTNRVSDLSWNPNNKWV-LASLADDNILQIW 410 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 52/286 (18%), Positives = 111/286 (38%), Gaps = 42/286 (14%) Query: 44 HTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY--------DGKFEKTISGHKLGISDVA 94 H V+ +F P N + +A+ + I+ + + H + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 95 WSS-DSNLLVSASDDKTLKIWDVSSGK----------CLKTLKGHSNYVFCCNFNPQSN- 142 W+ L + ++D ++ +WD+ + H+ V F+ Q Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 143 LIVSGSFDESVRIWDVK---TGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIW 198 L+ S S D +++I D + + + + AH PV+ V FN + L+ ++S D +W Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSK------------ 245 D ++ V V++SP+ + ++ ++ D + +WD SK Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 246 --GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 + + + GH N + ++ + S ++DN++ IW+ Sbjct: 370 GAPELMFMHGGHTNRVSDLS--WNPNNKWVLASLADDNILQIWSPS 413 >4L9O-A nrPDB Length = 349 Score = 143 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 55/230 (23%), Positives = 101/230 (43%), Gaps = 20/230 (8%) Query: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW--DVKTGKCLKTLPAHSDPVSAVHF 179 + H + + + + + S D++++I+ D + + ++TL H PV V + Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 180 N--RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATL 234 + G ++ S SYDG IW +G K V+ V ++P+ G +L A+ Sbjct: 122 AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS 181 Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS----VTGGKWIVSGSEDNLVYIWNLQ- 289 D + + ++ G L+ + A+++ + VSG DNLV IW Sbjct: 182 DGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDD 241 Query: 290 ---TKEIVQKLQGHTDVVISTACHP---TENIIASAALENDKTIKLWKSD 333 T + QGH+D V A P +++ IA+A+ D+T+ +W D Sbjct: 242 AAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATAS--QDRTVLIWTKD 289 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 67/268 (25%), Positives = 110/268 (41%), Gaps = 25/268 (9%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSD-- 98 H + G LA+ S+DK IKI+ + + +T+ GH+ + VAW+ Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 99 SNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNP--QSNLIVSGSFDESVR 154 +L S S D + IW +G + H V ++ P +++ S D + Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 155 IWDVKTGKCLK--TLPAHSDPVSAVHFNR-----DGSLIVSSSYDGLCRIW---DTASGQ 204 I + K G L+ + H+ V+A + + VS D L +IW D A Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTF 246 Query: 205 CLKTLIDDDNPPVSFVKFSP---NGKYILAATLDNTLKLW--DYSKGK-CLKTYTGHKNE 258 + + V V +SP + YI A+ D T+ +W D K + T K Sbjct: 247 IEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFP 306 Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIW 286 C A++S++G +SG DN V +W Sbjct: 307 DVCWRASWSLSGNVLAISGG-DNKVTLW 333 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 113/273 (41%), Gaps = 25/273 (9%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS--SGKCLKTLKGHSNYVFCCNF-NPQ 140 + H I D L + S DKT+KI+++ + + ++TL GH V+ + +P+ Sbjct: 66 NAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPK 125 Query: 141 -SNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLC 195 ++ S S+D V IW G + H V++V + G +++ +S DG Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 196 RIWDTASGQCLK-TLIDDDNPPVSFVKFSP-----NGKYILAATLDNTLKLWDYSKGKC- 248 I + G L+ +I V+ ++P N + ++ DN +K+W Y Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKT 245 Query: 249 ---LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI---VQKLQGHT- 301 + + GH + + + S +I + S+D V IW K Q L Sbjct: 246 FIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKF 305 Query: 302 -DVVISTACHPTENIIASAALENDKTIKLWKSD 333 DV + + N++A + D + LWK + Sbjct: 306 PDVCWRASWSLSGNVLAISG--GDNKVTLWKEN 336 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 61/232 (26%), Positives = 95/232 (40%), Gaps = 24/232 (10%) Query: 34 NYALKFTLAGHTKAVSSVKF-SPN-GEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLG 89 N L TL GH V V + P G LAS S D + IW +G + K H+ Sbjct: 102 NQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQAS 161 Query: 90 ISDVAWSS--DSNLLVSASDDKTLKIWDVSSGKCLK--TLKGHSNYVFCCNFNP-----Q 140 ++ V+W+ +L+ AS D + I + G L+ ++GH+ V ++ P Sbjct: 162 VNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDN 221 Query: 141 SNLIVSGSFDESVRIW--DVKTGKCLKT--LPAHSDPVSAVHFNR---DGSLIVSSSYDG 193 + VSG D V+IW D ++ HSD V V ++ S I ++S D Sbjct: 222 TRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDR 281 Query: 194 LCRIW--DTASGQCLKT--LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 IW D S + K + +S +G + + DN + LW Sbjct: 282 TVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 >5WLC-LJ nrPDB Length = 513 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 131/303 (43%), Gaps = 36/303 (11%) Query: 1 MATEEKKPE----TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPN 56 ++ + P T + R Q S + + T + V S F + Sbjct: 45 ISFNPQHPHDFAVTSSTRVQIFSSRTR------------QVIKTFSRFKDVVYSASFRSD 92 Query: 57 GEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIW 114 G+ L + A L+ ++ +Y+ +I+ + D+ +L +ASDD+ ++W Sbjct: 93 GKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLW 152 Query: 115 DVSSG-KCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPA-HS 171 D+S+ + L G ++YV +F P + +L+ +GS+D +R++D ++ H Sbjct: 153 DISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHD 212 Query: 172 DPV-SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-----SPN 225 PV + + + + IVS + ++WD S + L + N V+ + + SP Sbjct: 213 QPVENVIAVSP--TQIVSCGGNNF-KVWDLTSNKKLYE-RGNFNKAVTCLDYVENFDSPM 268 Query: 226 GKYILAATLDNTLKLWDYSKGKCLK---TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 ++A++LD +K++D +K ++G C + + G + +V+G L Sbjct: 269 QSALIASSLDGHVKVFDPLDNFQVKFGWKFSGP--VLSCAVSPSTAQGNRHLVAGLSSGL 326 Query: 283 VYI 285 + I Sbjct: 327 LAI 329 Score = 58.1 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 11/138 (7%) Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 R W + L+ + N V+ + F+P + A T ++++ + +KT++ Sbjct: 25 RYWRQYTS---AQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRF 80 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACH-PTE 313 K+ +++ + GK + +G LV +++ + I+ + T T H Sbjct: 81 KD---VVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDN 137 Query: 314 NIIASAALENDKTIKLWK 331 I+A+A+ +D+ +LW Sbjct: 138 KILATAS--DDRVTRLWD 153 >3ACP-A nrPDB Length = 417 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 58/320 (18%), Positives = 130/320 (40%), Gaps = 39/320 (12%) Query: 9 ETEAARAQPTPSSSATQSKPTPVKPNYALKFTL-AGHTKAVSSVKFSPNGEWLASSSADK 67 +T + + T+ + N+ L+ + H ++ +KF P+GE L SSS D Sbjct: 100 DTAKLQMRRFI-LGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDM 158 Query: 68 LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127 +KIW DG +T+ GH+ ++D+A ++SAS D T+++W+ +G + T Sbjct: 159 QLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNR 218 Query: 128 HSNY---VFCCN---------------------FNPQSNLIVSGSFDESVRIWDVKTGKC 163 N V F +++G + + +V + + Sbjct: 219 KENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQ 278 Query: 164 LKTLPA-HSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFV 220 LP+ + +++ + + + I + +G+ WD S +C + + ++ P++ V Sbjct: 279 TIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNV 338 Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG---------G 271 F+ G +++ D ++KL S + + + + + + V+ Sbjct: 339 YFAA-GALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESN 397 Query: 272 KWIVSGSEDNLVYIWNLQTK 291 ++ ++N ++NL Sbjct: 398 GEVLEVGKNNFCALYNLSNP 417 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 47/255 (18%), Positives = 97/255 (38%), Gaps = 29/255 (11%) Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 + + + +K+ D S+ + + + H + + F P ++S S D ++IW V Sbjct: 107 RRFILGTTEGDIKVLD-SNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSV 165 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------- 209 K G +TL H V+ + G ++S+S DG R+W+ +G + T Sbjct: 166 KDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDG 225 Query: 210 --------------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255 + + ++F GKY++A + + + + + Sbjct: 226 VNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPS- 284 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTEN 314 K C +I +G E+ ++ W+L++ E V + + I+ Sbjct: 285 KFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGA 344 Query: 315 IIASAALENDKTIKL 329 + S+ D +IKL Sbjct: 345 LFVSSGF--DTSIKL 357 Score = 67.3 bits (163), Expect = 9e-12, Method: Composition-based stats. Identities = 36/154 (23%), Positives = 63/154 (40%), Gaps = 7/154 (4%) Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237 F + GS + + DG +++T K L D V K + + T + Sbjct: 60 TFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKL--QMRRFILGTTEGD 117 Query: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 297 +K+ D + + H +E I G+ ++S S+D + IW+++ + L Sbjct: 118 IKVLDSNFNLQREIDQAHVSE---ITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTL 174 Query: 298 QGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 GH V A + SA+L D TI+LW+ Sbjct: 175 IGHRATVTDIAIIDRGRNVLSASL--DGTIRLWE 206 >5WLC-LU nrPDB Length = 489 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 124/324 (38%), Gaps = 45/324 (13%) Query: 43 GHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS---- 97 GH V ++ + LA+ SAD +IK W + + H ++ + + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 98 -------DSNLLVSASDDKTLKIWDV-----------------SSGKCLKTLKGHSNYVF 133 N ++S SDDKT+K+W + + ++T G S + Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF-Q 183 Query: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS-LIVSSSYD 192 + + +++ +G + +WDV K + L +D ++++ FN++ + ++ S+ D Sbjct: 184 GIDSHRENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSD 241 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY-ILAATLDNTLKLWDYSKGKCLKT 251 ++D + + ++ + + ++P + + A D+ +D ++ Sbjct: 242 NSIVLYDLRTNSPTQKIVQTMRT--NAICWNPMEAFNFVTANEDHNAYYYDMRNLS--RS 297 Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV---VISTA 308 K+ + G IV+GS D + I+ + HT V Sbjct: 298 LNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQHVFQVK 355 Query: 309 CHPTENIIASAALENDKTIKLWKS 332 I S + +D ++LW+S Sbjct: 356 YSMDSKYIISGS--DDGNVRLWRS 377 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 109/283 (38%), Gaps = 36/283 (12%) Query: 40 TLAGHTKAVSSVKFSP-----------NGEWLASSSADKLIKIWGAY------------- 75 + H V+ + + + ++ S S DK +K+W Sbjct: 105 SFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDND 164 Query: 76 ----DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131 + +T G + +++ + + +WDV+ K + L ++ Sbjct: 165 SVTNEEGLIRTFDGESAF-QGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADN 221 Query: 132 VFCCNFNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL-IVSS 189 + FN ++++ S D S+ ++D++T + + + +A+ +N + V++ Sbjct: 222 ITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKI-VQTMRTNAICWNPMEAFNFVTA 280 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 + D +D + + D V V FSP G I+ + D +++++ + G Sbjct: 281 NEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSR 340 Query: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 + Y H +F K+I+SGS+D V +W + E Sbjct: 341 EIY--HTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWE 381 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 109/279 (39%), Gaps = 38/279 (13%) Query: 85 GHKLGISDVAWSSDS-NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN-----FN 138 GH+ G+ +A + S N L + S D +K W++S+ + + K H V F+ Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 139 PQ------SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS----------------A 176 + N ++S S D++V++W + + +D V+ Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQG 184 Query: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK-YILAATLD 235 + +R+ S + +WD + + L ++ +KF+ N + + D Sbjct: 185 IDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGA-DNITSLKFNQNETDILASTGSD 241 Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIV 294 N++ L+D + + V+ +ED+ Y ++++ + Sbjct: 242 NSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFN---FVTANEDHNAYYYDMRNLSRSL 298 Query: 295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 + H V+ PT + I + + DK+I+++K++ Sbjct: 299 NVFKDHVSAVMDVDFSPTGDEIVTGSY--DKSIRIYKTN 335 Score = 107 bits (266), Expect = 9e-24, Method: Composition-based stats. Identities = 46/214 (21%), Positives = 86/214 (40%), Gaps = 7/214 (3%) Query: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 90 V L T G A + A+ A I +W K +S I Sbjct: 166 VTNEEGLIRTFDG-ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNI 222 Query: 91 SDVAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGS 148 + + ++ + +++L S D ++ ++D+ + + + + +NP V+ + Sbjct: 223 TSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFNFVTAN 281 Query: 149 FDESVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 D + +D++ + L H V V F+ G IV+ SYD RI+ T G + Sbjct: 282 EDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSRE 341 Query: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 V VK+S + KYI++ + D ++LW Sbjct: 342 IYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 >6BX3-B nrPDB Length = 412 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 123/312 (39%), Gaps = 33/312 (10%) Query: 50 SVKFSPNGEWLASSSADKLIKIWGAYD----GKFEKTISGHKLGISDVAWSSDSNLLVSA 105 ++FSP G++LA A+ + I+ + H I+ +AWS D LL+++ Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 89 Query: 106 SDDKTLKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSG------------SFDES 152 S D ++K+WD+S K LK ++ S C + + L V+ S D Sbjct: 90 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 149 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASGQCLKTL 209 + K L + P H + + ++I+ + G + +C+ +L Sbjct: 150 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSL 209 Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--------KGKCLKTYTGHKNEKYC 261 + + + S NG+ + D T++ ++ S + Y N+ Sbjct: 210 -KITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQW 268 Query: 262 IFANFSVTGGKWIVS---GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318 FS +++V+ GS + +YIW + +V+ L+G + +I I S Sbjct: 269 NCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVS 328 Query: 319 AALENDKTIKLW 330 E+ + +W Sbjct: 329 NGFES-GNVYVW 339 >4BZK-B nrPDB Length = 297 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAHSDPVSAVHFNR-- 181 H+ + + + + S D++++I++V+ T K + TL H PV V + Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDD-DNPPVSFVKFSPN--GKYILAATLDNTL 238 G+++ S SYDG IW +G+ + + + V+ V+++P+ G +L A+ D + Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 239 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG------------GKWIVSGSEDNLVYIW 286 + ++ + + A+++ + V+G DNLV IW Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 287 ----NLQTKEIVQKLQGHTDVVISTACHPTENIIA-SAALENDKTIKLWKSD 333 + QT + L+GH+D V A PT + + A++ D+T +W D Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQD 237 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 104/275 (37%), Gaps = 31/275 (11%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFEKTISGHKLGISDVAWSSD-- 98 H + + G+ LA+ S+DK IKI+ K T++GH+ + V W+ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 99 SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNP--QSNLIVSGSFDESVR 154 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 155 IWDVKTGKCLK--TLPAHSDPVSAVHFNR-------------DGSLIVSSSYDGLCRIWD 199 + + K + AH+ V++ + + V+ D L +IW Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 200 TASG---QCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLKT 251 S L++ ++ + V V +SP Y+ + + D T +W D +G KT Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 + ++ G + DN V +W Sbjct: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 114/281 (40%), Gaps = 33/281 (11%) Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNF-NPQ 140 + H I D L + S DKT+KI++V + K + TL GH V+ ++ +P+ Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 141 -SNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLC 195 ++ S S+D V IW + G + HS V++V + G L++ +S DG Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 196 RIWDTA-SGQCLKTLIDDDNPPVSFVKFSP-------------NGKYILAATLDNTLKLW 241 + + +G +ID V+ ++P + + DN +K+W Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 242 ----DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW--NLQTKEIVQ 295 D T GH + + + +V ++ S S+D IW + + + Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKK 245 Query: 296 KLQGHT---DVVISTACHPTENIIASAALENDKTIKLWKSD 333 L DV+ + + N++A + D + LWK + Sbjct: 246 TLLKEEKFPDVLWRASWSLSGNVLALSG--GDNKVTLWKEN 284 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 62/239 (25%), Positives = 99/239 (41%), Gaps = 32/239 (13%) Query: 35 YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGI 90 + L TL GH V V ++ G LAS S D + IW +G++ + + H + Sbjct: 43 HKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASV 102 Query: 91 SDVAWSS--DSNLLVSASDDKTLKI--WDVSSGKCLKTLKGHSNYVFCCNFNP------- 139 + V W+ LL+ AS D + + + + + H+ V ++ P Sbjct: 103 NSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 Query: 140 ------QSNLIVSGSFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFNRD---GSLI 186 +S V+G D V+IW D +T TL HSD V V ++ S + Sbjct: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 Query: 187 VSSSYDGLCRIW--DTASGQCLKTLIDDDNPP--VSFVKFSPNGKYILAATLDNTLKLW 241 S S D C IW D G KTL+ ++ P + +S +G + + DN + LW Sbjct: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 61.9 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 41/112 (36%), Gaps = 5/112 (4%) Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY--SKGKCLKTYTGHKNEKYCIF 263 + + + N + GK + + D T+K+++ K + T TGH+ + + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKE--IVQKLQGHTDVVISTACHPTE 313 G + S S D V IW + + H+ V S P E Sbjct: 61 -WAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHE 111 >3JRP-A nrPDB Length = 379 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 105/275 (38%), Gaps = 31/275 (11%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFEKTISGHKLGISDVAWSSD-- 98 H + + G+ LA+ S+DK IKI+ K T++GH+ + V W+ Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 99 SNLLVSASDDKTLKIWDVSSGKC--LKTLKGHSNYVFCCNFNP--QSNLIVSGSFDESVR 154 +L S S D + IW +G+ + HS V + P L++ S D V Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 155 IWDVKTGKCLK--TLPAHSDPVSAVHFNR-----DGSL--------IVSSSYDGLCRIWD 199 + + K + AH+ V++ + DG V+ D L +IW Sbjct: 129 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Query: 200 TASG---QCLKTLIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLW--DYSKGKCLKT 251 S L++ ++ + V V +SP Y+ + + D T +W D +G KT Sbjct: 189 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 248 Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 + ++ G + DN V +W Sbjct: 249 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 63/288 (21%), Positives = 115/288 (39%), Gaps = 33/288 (11%) Query: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFC 134 G + H I D L + S DKT+KI++V + K + TL GH V+ Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 135 CNF-NPQ-SNLIVSGSFDESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRD--GSLIVS 188 ++ +P+ ++ S S+D V IW + G + HS V++V + G L++ Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 120 Query: 189 SSYDGLCRIWDTA-SGQCLKTLIDDDNPPVSFVKFSP-------------NGKYILAATL 234 +S DG + + +G +ID V+ ++P + + Sbjct: 121 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 180 Query: 235 DNTLKLW----DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 DN +K+W D T GH + + + +V ++ S S+D IW Sbjct: 181 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 240 Query: 291 KE---IVQKLQGHT--DVVISTACHPTENIIASAALENDKTIKLWKSD 333 ++ L+ DV+ + + N++A + D + LWK + Sbjct: 241 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSG--GDNKVTLWKEN 286 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 63/239 (26%), Positives = 99/239 (41%), Gaps = 32/239 (13%) Query: 35 YALKFTLAGHTKAVSSVKF-SPN-GEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGI 90 + L TL GH V V + P G LAS S D + IW +G++ + + H + Sbjct: 45 HKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASV 104 Query: 91 SDVAWSS--DSNLLVSASDDKTLKI--WDVSSGKCLKTLKGHSNYVFCCNFNP------- 139 + V W+ LL+ AS D + + + + + H+ V ++ P Sbjct: 105 NSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 164 Query: 140 ------QSNLIVSGSFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFNRD---GSLI 186 +S V+G D V+IW D +T TL HSD V V ++ S + Sbjct: 165 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 224 Query: 187 VSSSYDGLCRIW--DTASGQCLKTLIDDDNPP--VSFVKFSPNGKYILAATLDNTLKLW 241 S S D C IW D G KTL+ ++ P + +S +G + + DN + LW Sbjct: 225 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 >2AQ5-A nrPDB Length = 402 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 95/222 (42%), Gaps = 17/222 (7%) Query: 85 GHKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSG-------KCLKTLKGHSNYVFCCN 136 GH + D+AW + N++ S S+D T+ +W++ G + + TL+GH+ V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 137 FNPQ-SNLIVSGSFDESVRIWDVKTGKCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDG 193 ++P N+++S D + +WDV TG + TL H D + +V ++RDG+LI +S D Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 194 LCRIWDTASGQCLKTLIDDD--NPPVSFVKFSPNGKYILAA---TLDNTLKLWDYSKGKC 248 R+ + G + PV V F GK + + + LWD + Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHLEE 257 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290 + + F + G D+ + + + + Sbjct: 258 PLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 Score = 117 bits (292), Expect = 8e-27, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 23/243 (9%) Query: 23 ATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDG---- 77 K V N L + GHT V + + P N +AS S D + +W DG Sbjct: 62 LPLGKTGRVDKNVPL---VCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVL 118 Query: 78 ---KFEKTISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKG--HSNY 131 + T+ GH + VAW N+L+SA D + +WDV +G + TL H + Sbjct: 119 PLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDT 178 Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA-HSD--PVSAVHFNRDGSLIVS 188 ++ +++ LI + D+ VR+ + + G + H PV AV F +G ++ + Sbjct: 179 IYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTT 237 Query: 189 S---SYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYI-LAATLDNTLKLWDY 243 + +WDT + +L + D + V F P+ + L D++++ ++ Sbjct: 238 GFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEI 297 Query: 244 SKG 246 + Sbjct: 298 TSE 300 Score = 90.5 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 71/187 (37%), Gaps = 16/187 (8%) Query: 159 KTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASG------QCLKTLID 211 + K + + H+ PV + + + ++I S S D +W+ G + ++ Sbjct: 69 RVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLE 128 Query: 212 DDNPPVSFVKFSPN-GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270 V V + P +L+A DN + +WD G + T G I++ Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL-GPDVHPDTIYSVDWSRD 187 Query: 271 GKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASA-ALENDK 325 G I + D V + + +V + +G T V + I+ + + +++ Sbjct: 188 GALICTSCRDKRVRVIEPRKGTVVAEKDRPHEG-TRPVHAVFVS-EGKILTTGFSRMSER 245 Query: 326 TIKLWKS 332 + LW + Sbjct: 246 QVALWDT 252 Score = 52.7 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 57/130 (43%), Gaps = 12/130 (9%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK-TISGHKL--GISDVAWSSDSN 100 H + SV +S +G + +S DK +++ G H+ + V + S+ Sbjct: 175 HPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGK 233 Query: 101 LLVSA---SDDKTLKIWDVSSGK---CLKTLKGHSNYVFCCNFNPQSNLI-VSGSFDESV 153 +L + ++ + +WD + L+ L S+ V F+P +N++ + G D S+ Sbjct: 234 ILTTGFSRMSERQVALWDTKHLEEPLSLQELDT-SSGVLLPFFDPDTNIVYLCGKGDSSI 292 Query: 154 RIWDVKTGKC 163 R +++ + Sbjct: 293 RYFEITSEAP 302 >5N4A-A nrPDB Length = 771 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 41/207 (19%), Positives = 87/207 (42%), Gaps = 5/207 (2%) Query: 24 TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83 T + ++ ++ GH A S+++S +G LA++ D +KIW +G T+ Sbjct: 83 TDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWS-RNGMLRSTL 141 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 + + + W+ D + L + + I +SS K H V +++P ++L Sbjct: 142 AQADSPVYSIVWAYDCDQLCYCTGSNVV-IKSLSSNAKQNAWKAHDGVVLKVDWSPINHL 200 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203 I++G D ++WD G+ L PV++V + G L + ++ D G Sbjct: 201 IITGGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGF-NTLQLCD-RMG 257 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYIL 230 + +D + + ++ + + Sbjct: 258 WAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 95/246 (38%), Gaps = 19/246 (7%) Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS---- 141 H + V W+ + L + SDD+T+ W++ G+ + + Y ++ P S Sbjct: 13 HSELTAAVGWNVWNE-LFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDMHWYPVSSKKT 70 Query: 142 -----NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196 ++ D SV+I +TG+ K++ H ++ ++ DG+ + ++ DG + Sbjct: 71 QAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVK 129 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256 IW +G TL D PV + ++ + + T N + + S + H Sbjct: 130 IWS-RNGMLRSTLAQAD-SPVYSIVWAYDCDQLCYCTGSNVV-IKSLSSNAKQNAWKAHD 186 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 + I++G ED +W+ ++ + V S A P+ + Sbjct: 187 G---VVLKVDWSPINHLIITGGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGELF 242 Query: 317 ASAALE 322 A Sbjct: 243 AVGGFN 248 Score = 90.8 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 84/213 (39%), Gaps = 18/213 (8%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KTGKCLKTLPA-----HSDPVSAVHFN 180 HS +N + L + S D+++ W++ + + + TL A H PVS+ Sbjct: 13 HSELTAAVGWNVWNELF-TCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 181 RDGS-LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239 G+ + + DG +I +G+ K+ I+ +++S +G + A D ++K Sbjct: 72 AGGTDVFAVACTDGSVKILS-RTGRVEKS-IEGHKGACISLRWSYDGTALATAGEDGSVK 129 Query: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG 299 +W S+ L++ + +GS V I +L + + Sbjct: 130 IW--SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGS---NVVIKSLSSNAKQNAWKA 184 Query: 300 HTDVVISTACHPTENIIASAALENDKTIKLWKS 332 H VV+ P ++I + D K+W S Sbjct: 185 HDGVVLKVDWSPINHLIITGG--EDCKYKVWDS 215 Score = 37.7 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 18/132 (13%), Positives = 35/132 (26%), Gaps = 51/132 (38%) Query: 248 CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL------------------- 288 LK N + A + + S+D ++ WN+ Sbjct: 2 RLKVKQSSANVHSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMH 61 Query: 289 ------------------------------QTKEIVQKLQGHTDVVISTACHPTENIIAS 318 +T + + ++GH IS +A+ Sbjct: 62 WYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALAT 121 Query: 319 AALENDKTIKLW 330 A D ++K+W Sbjct: 122 AG--EDGSVKIW 131 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 14/94 (14%), Positives = 36/94 (38%), Gaps = 11/94 (11%) Query: 68 LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS-SGKCLKTLK 126 ++ + G+ H L + ++A S + +D+ L + D + L +K Sbjct: 440 TVRFFDTAQGRPVGEPWQHTLEVKEIALSQAGTI-----NDRQLIVIDRNRDLYLLPVMK 494 Query: 127 GH----SNYVFCCNFNPQSNLIVSGSFDESVRIW 156 H + ++ + ++ S D+ + +W Sbjct: 495 RHVAKLAAMCDSARWHDSTAML-SAMVDQRLCVW 527 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 37/93 (39%), Gaps = 8/93 (8%) Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 +VR +D G+ + H+ V + ++ G++ D + D L ++ Sbjct: 440 TVRFFDTAQGRPVGEPWQHTLEVKEIALSQAGTI-----NDRQLIVIDRNRDLYLLPVMK 494 Query: 212 DDNPPVSFVKFSP---NGKYILAATLDNTLKLW 241 ++ + S + +L+A +D L +W Sbjct: 495 RHVAKLAAMCDSARWHDSTAMLSAMVDQRLCVW 527 >5CXC-A nrPDB Length = 510 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 80/364 (21%), Positives = 132/364 (36%), Gaps = 78/364 (21%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKF----SPNGEW------ 59 + + T + +S PV + + H VS+V SP G W Sbjct: 97 SNGLSLETTLTLQYVRSLIPPV-----YEASFE-HDDWVSAVDVLSATSPAGRWSSAANS 150 Query: 60 ----------LASSSADKLIKIWGAYDGKFEKTIS----GHKLGISDVAWSSDSNLLVSA 105 + S+S D L++IW A + S GH I + + S+ L SA Sbjct: 151 SAAVQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLT-SDRLASA 209 Query: 106 SDDKTLKIW-----DVSSGKCLKTLK--GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 D+T+++W D +G+ TL+ GH+ V + + S I++ S D ++ W Sbjct: 210 GMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSA 269 Query: 159 KTGKC----LKTLPA--------------------------HSDPVSAVHFNR-DGSLIV 187 LP H+ P +A F+ D ++ Sbjct: 270 SKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAY 329 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK---YILAATLDNTLKLWD-- 242 S+S D R D +GQ + TL P +S + G + A T + + D Sbjct: 330 SASQDHTVRTLDLTTGQVVSTLTLTH-PLLSLSALTRAGTTSPLLAAGTSARHITMVDPR 388 Query: 243 -YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301 S + T GH N+ + + S +VSGS D +W+L++ K +G Sbjct: 389 ASSATTSVMTLRGHANK--VVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSL 446 Query: 302 DVVI 305 V Sbjct: 447 GGVS 450 Score = 54.6 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 13/118 (11%) Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDN 281 P + +L+A+ D L++W+ S G + T H I A +T + + S D Sbjct: 156 PGQERVLSASYDGLLRIWNAS-GSVIATSPSGSHGGHTASIKAAKFLTSDR-LASAGMDR 213 Query: 282 LVYIWNLQ-----TKEIVQKLQ--GHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 V +W T E+ L+ GHT V I +A+ D I W + Sbjct: 214 TVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASA--DGAIGFWSA 269 >2PM9-A nrPDB Length = 416 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 60/312 (19%), Positives = 123/312 (39%), Gaps = 27/312 (8%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNL 101 H K V + +G A+ S D +++W EK I+ ++ +D+ WS ++ + Sbjct: 22 HDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKI 81 Query: 102 LVSASDDKTLKIWDVSSGK----CLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIW 156 + A D+ +L+++ + + HS+ V FN Q N++ SG + + IW Sbjct: 82 IAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIW 141 Query: 157 DVKTGKCLKT-----LPAHS----DPVSAVHFNRD-GSLIVSSSYDGLCRIWDTA-SGQC 205 D+ + P S D V ++ +N+ + S+ IWD + Sbjct: 142 DMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEV 201 Query: 206 LKTLIDDDNPPVSF----VKFSP-NGKYILAATL---DNTLKLWDYSKGKCLKTYTGHKN 257 + N + V++ P N + AT D ++ +WD + Sbjct: 202 IHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGH 261 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE-NII 316 +K + ++ ++S DN V +WN ++ E + + + T P ++ Sbjct: 262 QKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLF 321 Query: 317 ASAALENDKTIK 328 A A+ +N ++ Sbjct: 322 ACASFDNKIEVQ 333 Score = 91.2 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 49/225 (21%), Positives = 93/225 (41%), Gaps = 26/225 (11%) Query: 41 LAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAY-----DGKFEKTISGHKLG----I 90 + H+ +V +VKF+ LAS + I IW + G + + Sbjct: 109 FSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEV 168 Query: 91 SDVAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTL------KGHSNYVFCCNFNPQSNL 143 +AW+ +++ SA IWD+ + K + L G + ++P+++ Sbjct: 169 ISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNST 228 Query: 144 ---IVSGSF-DESVRIWDVKT-GKCLKTL-PAHSDPVSAVHF-NRDGSLIVSSSYDGLCR 196 +GS D S+ IWD++ L+TL H + ++ + ++D L++SS D Sbjct: 229 RVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVL 288 Query: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPN-GKYILAATLDNTLKL 240 +W+ S + L N KF+P A+ DN +++ Sbjct: 289 LWNPESAEQLSQFPARGN-WCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 48.9 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 30/82 (36%), Gaps = 2/82 (2%) Query: 34 NYALKFTLAGHTKAVSSVKF-SPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 N L+ GH K + S+ + + L SS D + +W + Sbjct: 251 NTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFK 310 Query: 93 VAWSSD-SNLLVSASDDKTLKI 113 ++ + +L AS D +++ Sbjct: 311 TKFAPEAPDLFACASFDNKIEV 332 >5FA5-B nrPDB Length = 367 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 122/313 (38%), Gaps = 26/313 (8%) Query: 28 PTPVKPNYALKFTLAGH-----TKAVSSVKFSPNGEWLASSSA-DKLI---KIW------ 72 P P+ P A ++ L + + + + ++ +G L +S+ +W Sbjct: 31 PPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPC 90 Query: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG----H 128 A + F + G++D+ W + +LV ASD +++W++ + L K H Sbjct: 91 AAPNEGFCSAGVQTEAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEH 149 Query: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD-GSLIV 187 + V + VSGS D +++WD+ L + AH+ V+ V + S+ + Sbjct: 150 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFL 209 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPV-SFVKFSPNG-KYILAATLDNTLKLWDYSK 245 S S D +WDT + + + + + + P + + + T+ L D Sbjct: 210 SCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKS 269 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305 C+ + H FS ++ S SED + + + E+ + Q H D V Sbjct: 270 TSCVLSSAVHSQ--CVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVR 326 Query: 306 STACHPTENIIAS 318 P + + + Sbjct: 327 DATWSPLNHSLLT 339 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 95/233 (40%), Gaps = 13/233 (5%) Query: 60 LASSSADKLIKIWGAYDGKFEKTIS----GHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115 + +S +++W + + H +S V+ S VS S D +K+WD Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 116 VSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKCLKTL--PAHSD 172 ++ L + + H+ V C +P + + +S S D + +WD + K + A Sbjct: 179 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGY 238 Query: 173 PVSAVHFNRD-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG-KYIL 230 +++ ++ + V +G + DT S C+ + + V+ + FSP+ ++ Sbjct: 239 LPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQCVTGLVFSPHSVPFLA 297 Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 + + D +L + D S + + + + A +S + + D+ V Sbjct: 298 SLSEDCSLAVLDSSLSEL---FRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 90.5 bits (223), Expect = 8e-19, Method: Composition-based stats. Identities = 42/203 (20%), Positives = 75/203 (36%), Gaps = 8/203 (3%) Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP----AHSDPVSAVHFNRDGSLIV 187 V + + ++V S +V +W++ + L H D VS V G+ V Sbjct: 108 VADLTWVGERGILV-ASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAV 166 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG-KYILAATLDNTLKLWDYSKG 246 S S D ++WD A Q + + V+ V SP+ L+ + DN + LWD Sbjct: 167 SGSKDICIKVWDLAQ-QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 225 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 K + + V G E+ V + + ++ V H+ V Sbjct: 226 KPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTG 285 Query: 307 TACHPTENIIASAALENDKTIKL 329 P ++ A+L D ++ + Sbjct: 286 LVFSPH-SVPFLASLSEDCSLAV 307 Score = 80.4 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 39/166 (23%), Positives = 66/166 (39%), Gaps = 9/166 (5%) Query: 37 LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI---SD 92 + + H V+ V SP+ S S D I +W K I G + Sbjct: 184 VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGYLPTS 242 Query: 93 VAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFD 150 +AW S + V ++ T+ + D S C+ + HS V F+P S + S S D Sbjct: 243 LAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSED 302 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLC 195 S+ + D + ++ AH D V ++ + SL+ + +D Sbjct: 303 CSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 60.8 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 2/107 (1%) Query: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV-TGGKWIVSGSEDNLVYIWN 287 IL A+ ++LW+ + + L K E I + SV + G VSGS+D + +W+ Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 334 L + ++ + H V A P ++ + + D I LW + C Sbjct: 179 LAQQVVLSSYRAHAAQVTCVAASPHKDSVFL-SCSEDNRILLWDTRC 224 Score = 29.2 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 10/55 (18%), Positives = 18/55 (32%), Gaps = 1/55 (1%) Query: 17 PTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIK 70 P +S + + + + F H V +SP N L + D + Sbjct: 294 PFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVV 348 >4G56-B nrPDB Length = 357 Score = 127 bits (319), Expect = 8e-30, Method: Composition-based stats. Identities = 55/232 (23%), Positives = 94/232 (40%), Gaps = 11/232 (4%) Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG----HSNYVFCCNFNPQSN 142 + G++DVAW S+ +LV ASD +++W++ + L K H + V + Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTA 201 VSG D SV++WD+ LK+ AHS V+ V ++ +S DG +WDT Sbjct: 153 QAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTR 212 Query: 202 SGQCLKTLIDDDNPPV-SFVKFSPNG-KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259 + + + + + V + P + L + +T H Sbjct: 213 KPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNI 272 Query: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 + +S ++ S SED V + + E+ + L H D V A P Sbjct: 273 TGL--AYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS-HRDFVTGVAWSP 321 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 76/221 (34%), Gaps = 8/221 (3%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-DSNLL 102 H V ++ +G S D +K+W K+ + H ++ VA + Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIF 197 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYV--FCCNFNP-QSNLIVSGSFDESVRIWDVK 159 +S +D + +WD K + ++ ++P + + G +V + ++K Sbjct: 198 LSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIK 257 Query: 160 TGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 +T HS ++ + ++ + S S D + D + + L V+ Sbjct: 258 NPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDL--SHRDFVT 315 Query: 219 FVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258 V +SP + D+ + + K E Sbjct: 316 GVAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENLIATKAE 356 Score = 85.8 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 74/207 (35%), Gaps = 8/207 (3%) Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP----AHSDPVSAVHFNRDGSLIV 187 V + + ++V S +V +W++ + L H D V + DG+ V Sbjct: 97 VTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAV 155 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKG 246 S D ++WD + LK+ + + V+ V P L+ D + LWD K Sbjct: 156 SGGKDFSVKVWDLSQKAVLKS-YNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKP 214 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 K ++ + G E V + N++ + Q H+ + Sbjct: 215 KPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITG 274 Query: 307 TACHPTENIIASAALENDKTIKLWKSD 333 A + A++ D T+ + +D Sbjct: 275 LAYSYHSSPF-LASISEDCTVAVLDAD 300 Score = 78.1 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 61/173 (35%), Gaps = 7/173 (4%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTISGHKLGI--SD 92 A+ + H+ V+ V P + S D I +W K I + Sbjct: 172 AVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTS 231 Query: 93 VAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFD 150 V W + + + + + ++ + +T HS + ++ S+ + S S D Sbjct: 232 VTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISED 291 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTAS 202 +V + D + + L H D V+ V ++ D S + +D S Sbjct: 292 CTVAVLDADFSEVFRDLS-HRDFVTGVAWSPLDHSKFTTVGWDHKVLHHHLPS 343 Score = 27.7 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 9/54 (16%), Positives = 20/54 (37%), Gaps = 1/54 (1%) Query: 17 PTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLI 69 P +S + + +++ F H V+ V +SP + + D + Sbjct: 283 PFLASISEDCTVAVLDADFSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 >4XFV-A nrPDB Length = 792 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 70/382 (18%), Positives = 138/382 (36%), Gaps = 75/382 (19%) Query: 20 SSSATQSKPTPVKPNYA-LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK 78 + T + P++PN + TL GH V+ V+F P+ +++ S+S D +KIW D Sbjct: 37 GAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS 96 Query: 79 FEKTISG-HKLGISDVAWSSDSNLLVSASDDKTLKIW--DVSSGK--CLKTLKGHSN--Y 131 + I + VA S+ +L+ D T+ IW ++ + + Y Sbjct: 97 HLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFY 156 Query: 132 VFCCNFNP---QSNLIVSGSFDESVRIWD-------VKTGKCLKTLPAHSDPVSAVHF-- 179 C + + + L+ G + +V I ++ + + L H D V ++ F Sbjct: 157 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 216 Query: 180 --NRDGSLIVSSSYDGLCRIWDTASGQCL------------------------------- 206 L+ S S D R+W + Sbjct: 217 QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGIN 276 Query: 207 -KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---------------K 250 + LI + +S +++ + +LAAT D +L +W+ + + Sbjct: 277 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 336 Query: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK---LQGHTDVVIST 307 T TG + + F+ + ++ + +W + I + + G T V Sbjct: 337 TATG-SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 395 Query: 308 ACHPTENIIASAALENDKTIKL 329 A P+ + + +L D+T +L Sbjct: 396 AWSPSGEYLLATSL--DQTTRL 415 Score = 98.5 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 46/219 (21%), Positives = 86/219 (39%), Gaps = 29/219 (13%) Query: 136 NFNPQSNLIVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192 + + ++ G+ +++ +WD TL H V+ V F D +VS+S D Sbjct: 26 DIHKVKKIVAFGAG-KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASED 84 Query: 193 GLCRIW---DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--DYSKGK 247 +IW D + QC++T+ V S I D T+ +W + + Sbjct: 85 HHVKIWKFTDYSHLQCIQTIQHYSKTIV---ALSALPSLISVGCADGTISIWRQNIQNDE 141 Query: 248 --CLKTYTGHKN--EKYCIFANFSVTGGKWIVSGSEDNLVYIWN-------LQTKEIVQK 296 +T K C+ + + G + V+I + ++ +V + Sbjct: 142 FGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAE 201 Query: 297 LQGHTDVVISTAC----HPTENIIASAALENDKTIKLWK 331 L+GH D V S A P + ++ S + D+ I+LW+ Sbjct: 202 LEGHEDWVKSLAFRHQETPGDYLLCSGS--QDRYIRLWR 238 Score = 95.8 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 110/261 (42%), Gaps = 33/261 (12%) Query: 17 PTPSSSATQSKPTPVKPNYALKFT----LAGHTKAVSSVKFSPNGEWLASSSADKLI--- 69 T S + P + L + L GH ++ + SP+ + +AS+ + Sbjct: 530 ITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNA 589 Query: 70 --KIWGAYD-GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKCLKT 124 +I+ + + + + H L I+ + +S D L+S D+ +W ++ Sbjct: 590 VIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELR 649 Query: 125 L---KGHSNYVFCCNFNPQ--SNLIVSGSFDESVRIW----DVKTGKCLKTLPAHSDPVS 175 K H+ ++ ++ P N+ V+ S D++V++W + L+ H+ V+ Sbjct: 650 FKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVT 709 Query: 176 AVHFNRD---GSLIVSSS-YDGLCRIWDTASGQ-CLKTLIDDDNPP---VSFVKFS---P 224 A+ + +++S +G ++ G+ L T +++D P ++ +++S Sbjct: 710 AISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKR 769 Query: 225 NGKYIL-AATLDNTLKLWDYS 244 NGK L + D + +++ + Sbjct: 770 NGKLFLGVGSSDLSTRIYSLA 790 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 90/277 (32%), Gaps = 67/277 (24%) Query: 37 LKFTLAGHTKAVSSVKF----SPNGEWLASSSADKLIKIW-----GAYDGK--------- 78 + L GH V S+ F +P L S S D+ I++W D Sbjct: 198 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 257 Query: 79 -------------------FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW--DVS 117 FE I GH IS + W L++A+ D +L +W D + Sbjct: 258 LSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDET 317 Query: 118 SGKCLKTLKGHS--------------NYVFCCNF-NPQSNLIVSGSFDESVRIWDVKT-- 160 SG + +L+ + C F + + + ++ S R+W K Sbjct: 318 SGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNI 377 Query: 161 -GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI---WDTASGQCLKTLIDDDNPP 216 + + V+ + ++ G ++++S D R+ W + + + Sbjct: 378 ICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS 437 Query: 217 VSFVKFSP-------NGKYILAATLDNTLKLWDYSKG 246 + ++ + L+ +D KG Sbjct: 438 RPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKG 474 Score = 68.5 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 64/373 (17%), Positives = 123/373 (32%), Gaps = 68/373 (18%) Query: 14 RAQPTPSSSATQSKPTPVKPNYALKFTLA--------------GHTKAVSSVKFSPNGEW 59 R S SK + N KF + GH +SS+++ + Sbjct: 240 RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ 299 Query: 60 LASSSADKLIKIWGAY---------------DGKFEKTISGHKLGISDVAW--SSDSNLL 102 L +++AD + +W K T +G G W + Sbjct: 300 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFF 359 Query: 103 VSASDDKTLKIWDV-SSGKCLKTL--KGHSNYVFCCNFNPQSNLIVSGSFDESVRIW--- 156 ++ + ++W + C + L G + V ++P +++ S D++ R++ Sbjct: 360 LTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPW 419 Query: 157 ---------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--C 205 ++ T H + V D + VS + + R +D G Sbjct: 420 IYDASGRKREIATWHEFSRPQIHGYDMICVETVTD-TRFVSGGDEKILRSFDLPKGVAGM 478 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 L+ + S + P+ + L N K + + + G E I Sbjct: 479 LQKFVGIQFEEKSEM---PDSATVPVLGLSN--KAGEDDANEDDEEEEGGNKETPDITDP 533 Query: 266 FSVTGGKWIVSGSEDNLVY--IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323 S+ + ED L +W V+KL GH + P + +IASA N Sbjct: 534 LSLLECPPM----EDQLQRHLLW-----PEVEKLYGHGFEITCLDISPDQKLIASACRSN 584 Query: 324 ---DKTIKLWKSD 333 + I+++ ++ Sbjct: 585 NVQNAVIRIFSTE 597 Score = 58.1 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 13/113 (11%) Query: 227 KYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 K I+A T+ LWD + T GH+ E C+ V ++VS SED+ V Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV---RFVPDSDFMVSASEDHHV 87 Query: 284 YIW---NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 IW + + +Q +Q ++ +++ + P+ + A D TI +W+ + Sbjct: 88 KIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA----DGTISIWRQN 136 Score = 53.1 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 51/132 (38%), Gaps = 16/132 (12%) Query: 212 DDNPPVSFVKFSPNGKYILAATLDNT-----LKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 ++ + SP+ K I +A N ++++ S L+ I Sbjct: 560 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF--STENWLEIKPALPFHSLTITRLK 617 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL-----QGHTDVVISTACHPT--ENIIASA 319 GK+++S D +W ++ +L + HT ++ P N+ +A Sbjct: 618 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 677 Query: 320 ALENDKTIKLWK 331 + DKT+K+W+ Sbjct: 678 S--RDKTVKVWR 687 >4OWR-A nrPDB Length = 339 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 117/303 (38%), Gaps = 28/303 (9%) Query: 45 TKAVSSVKFSPN---GEWLASSSADKLIKIWGAYD--GKFEKTISGHKLGISDVAWSSDS 99 ++ + FSP G +L + S ++ W D K H + DV WS D Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF--NPQSNLIVSGSFDESVRIWD 157 + + +AS DKT K+WD+SS + ++ + H V ++ P + +++GS+D++++ WD Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----QCLKTLIDDD 213 ++ + L P + + V ++ + ++ + + +++ + Sbjct: 129 TRSSNPMMVLQL---PERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQ 185 Query: 214 NPPVSFVKFSPNGKY-ILAATLDNTLKLWDYSKGKCLK---TYTGHKNE---------KY 260 + V+ K N +++ + + + K T+ H++ Y Sbjct: 186 HRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIY 245 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320 + + + D W+ + ++ + + + + NI A A+ Sbjct: 246 AVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYAS 305 Query: 321 LEN 323 + Sbjct: 306 SYD 308 Score = 95.5 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 35/143 (24%), Positives = 67/143 (46%), Gaps = 9/143 (6%) Query: 122 LKTLKGHSNYVFCCNFNPQ---SNLIVSGSFDESVRIWDVKTGKCL--KTLPAHSDPVSA 176 ++ + + C +F+P N +++GS+ VR W+V+ K H+ PV Sbjct: 3 IEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLD 62 Query: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF--SPNGKYILAATL 234 V ++ DGS + ++S D ++WD +S Q ++ I + PV + + +PN ++ + Sbjct: 63 VCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ--IAQHDAPVKTIHWIKAPNYSCVMTGSW 120 Query: 235 DNTLKLWDYSKGKCLKTYTGHKN 257 D TLK WD + + Sbjct: 121 DKTLKFWDTRSSNPMMVLQLPER 143 Score = 86.2 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 95/263 (36%), Gaps = 32/263 (12%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW--SSDS 99 HT V V +S +G + ++S DK K+W + + I+ H + + W + + Sbjct: 54 QMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNY 112 Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159 + +++ S DKTLK WD S + L+ +C + ++ + + ++ ++ Sbjct: 113 SCVMTGSWDKTLKFWDTRSSNPMMVLQLP-ERCYCADVIYPMAVVATAER-GLI-VYQLE 169 Query: 160 TG----KCLKTLPAHSDPVSAVHFNRD----GSLIVSSSYDGLCRIW---------DTAS 202 + +++ H V +D + S +G I D + Sbjct: 170 NQPSEFRRIESPLKHQH--RCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFT 227 Query: 203 GQCLKTLIDDDNPP-----VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257 +C ++ + + P V+ + F P + D WD LKT Sbjct: 228 FKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQ 287 Query: 258 EKYCIFANFSVTGGKWIVSGSED 280 F+ G + + S D Sbjct: 288 PISACC--FNHNGNIFAYASSYD 308 Score = 57.7 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 52/130 (40%), Gaps = 9/130 (6%) Query: 209 LIDDDNPPVSFVKFSPN---GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 + + + + FSP G +++A + N ++ W+ + + Sbjct: 5 VTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVC 64 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC--HPTENIIASAALEN 323 +S G K + + S D +W+L + + +Q Q H V + P + + + + Sbjct: 65 WSDDGSK-VFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSW-- 120 Query: 324 DKTIKLWKSD 333 DKT+K W + Sbjct: 121 DKTLKFWDTR 130 Score = 51.9 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 37/85 (43%), Gaps = 4/85 (4%) Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK--EIVQKLQGHTDVVIS 306 ++ + + C+ + G ++++GS N V W +Q I + Q HT V+ Sbjct: 3 IEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLD 62 Query: 307 TACHPTENIIASAALENDKTIKLWK 331 + + +A+ DKT K+W Sbjct: 63 VCWSDDGSKVFTASC--DKTAKMWD 85 >6CHG-D nrPDB Length = 439 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 121/327 (37%), Gaps = 42/327 (12%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL----GIS 91 L TL AV VKFSP G++LA ++ I I+ K + H + Sbjct: 19 KLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQ 77 Query: 92 DVAWSSDSNLLVSASDDKTLKIWDVSS-GKCLKTLKGHSNYVFC--CNFN---------P 139 V WS+D L S+ D K+WD++ KC + K C +N P Sbjct: 78 SVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEP 137 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW- 198 + ++ + + + + + H + A S+I++ + G + Sbjct: 138 TAYVLTLTDRQNAFHCF--PLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQ 195 Query: 199 -DTASGQCLKT----LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW------DYSKG- 246 D SG K N + + SP+G I D T++ + + S+G Sbjct: 196 LDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGG 255 Query: 247 -------KCLKTYTGHKNEKYCIFANFSVTGGKWIVS---GSEDNLVYIWNLQTKEIVQK 296 + Y N FS G+++V+ GS + +Y+W + +V+ Sbjct: 256 SSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRV 315 Query: 297 LQGHTDVVISTACHPTENIIASAALEN 323 L+G + ++ + IAS E+ Sbjct: 316 LEGADEELLDIDWNFYSMRIASNGFES 342 >5YZG-2 nrPDB Length = 646 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 49/233 (21%), Positives = 96/233 (41%), Gaps = 25/233 (10%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 101 H ++ V + +++ ++S D +K W + +F K H I +A SS+ L Sbjct: 89 HRDVITHVVCTKT-DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLK-----GHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 S DDK +K++DV + + LK G +++C + S++ S + I+ Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPG-DAISSVAASEKSTGKIFIY 206 Query: 157 DVK-TGKCLKTLPA-HSDPVSAVHFNRDGSLIVSSSYDGLCRIW-----DTASGQCLKTL 209 D + + L H+ P++ + N +VSS G+ W + + + Sbjct: 207 DGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWE 266 Query: 210 IDDDNPPV---------SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253 D + V FSP+GK I D ++++ + GK ++ + Sbjct: 267 YKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 Score = 72.3 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 33/239 (13%), Positives = 85/239 (35%), Gaps = 28/239 (11%) Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKTG-KCLKTLPAHSD 172 ++ S + H + + +++ I++ S D V+ W ++ G + +K +H Sbjct: 76 NLPSASMYERSYMHRDVITHV-VCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLG 134 Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN---GKYI 229 + ++ + +G+L S D +++D + + L P + P Sbjct: 135 VIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVA 194 Query: 230 LAATLDNTLKLWDYS-KGKCLKTYT-GHKNEKYCIFANFSVTGGKWIVSGSEDNLV---- 283 + + ++D + L + H + I N K +VS + ++ Sbjct: 195 ASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVY---KAVVSSDKSGMIEYWT 251 Query: 284 ----------YI-WNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + W +T + + S P IA+ + +D+ +++++ Sbjct: 252 GPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIAT--IGSDRKVRIFR 308 >5WLC-SG nrPDB Length = 573 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 119/309 (38%), Gaps = 29/309 (9%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 +K P + + T GH + +V SP+G+++ + D+ + +W K I Sbjct: 218 AKYIPTSK-HEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT 276 Query: 86 --HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 + + +A+ +S+ L ++ D ++ + ++ L+ L GH + V + Sbjct: 277 KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERC 336 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV-HFNRDGSLIVSSSYDGLCRIWDTAS 202 + G+ D + +W + L T +P + + ++ + DG + D Sbjct: 337 VTVGARDRTAMLWKIPDETRL-TFRGGDEPQKLLRRWMKENAK---EGEDGEVKYPD--E 390 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 + + VS V + + + + + + LW +K K + T + + I Sbjct: 391 SEAPLFFCEGSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFT----ERIAHGI 442 Query: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322 S +SG D + LQ K+++Q + S P N+ S + Sbjct: 443 LPEPSFND----ISGETDEELRKRQLQGKKLLQPF-----WITSLYAIPYSNVFISGSWS 493 Query: 323 NDKTIKLWK 331 ++K+WK Sbjct: 494 --GSLKVWK 500 Score = 46.5 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 64/183 (34%), Gaps = 18/183 (9%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD 66 +P+ R + + + A F G VS V + + S + Sbjct: 364 EPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMV----DDFHFITGSDN 419 Query: 67 KLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK 126 I +W K T + + +++ +S D+ L+ + K L+ Sbjct: 420 GNICLWSLAKKKPIFTERIAHGILPEPSFND-----ISGETDEELRKRQLQGKKLLQPF- 473 Query: 127 GHSNYVFCCNFNPQSNLIVSGSFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFNRD 182 ++ P SN+ +SGS+ S+++W ++++ + L L V+ + Sbjct: 474 ----WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVES 529 Query: 183 GSL 185 G Sbjct: 530 GKH 532 >4J0X-A nrPDB Length = 451 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 119/309 (38%), Gaps = 29/309 (9%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85 +K P + + T GH + +V SP+G+++ + D+ + +W K I Sbjct: 96 AKYIPTSK-HEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT 154 Query: 86 --HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 + + +A+ +S+ L ++ D ++ + ++ L+ L GH + V + Sbjct: 155 KDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERC 214 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV-HFNRDGSLIVSSSYDGLCRIWDTAS 202 + G+ D + +W + L T +P + + ++ + DG + D Sbjct: 215 VTVGARDRTAMLWKIPDETRL-TFRGGDEPQKLLRRWMKENAK---EGEDGEVKYPD--E 268 Query: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 + + VS V + + + + + + LW +K K + T + + I Sbjct: 269 SEAPLFFCEGSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFT----ERIAHGI 320 Query: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322 S +SG D + LQ K+++Q + S P N+ S + Sbjct: 321 LPEPSFND----ISGETDEELRKRQLQGKKLLQPF-----WITSLYAIPYSNVFISGSWS 371 Query: 323 NDKTIKLWK 331 ++K+WK Sbjct: 372 --GSLKVWK 378 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 64/183 (34%), Gaps = 18/183 (9%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD 66 +P+ R + + + A F G VS V + + S + Sbjct: 242 EPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMV----DDFHFITGSDN 297 Query: 67 KLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK 126 I +W K T + + +++ +S D+ L+ + K L+ Sbjct: 298 GNICLWSLAKKKPIFTERIAHGILPEPSFND-----ISGETDEELRKRQLQGKKLLQPF- 351 Query: 127 GHSNYVFCCNFNPQSNLIVSGSFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFNRD 182 ++ P SN+ +SGS+ S+++W ++++ + L L V+ + Sbjct: 352 ----WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVES 407 Query: 183 GSL 185 G Sbjct: 408 GKH 410 >3BG0-A nrPDB Length = 316 Score = 117 bits (293), Expect = 8e-27, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 109/284 (38%), Gaps = 47/284 (16%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--FEKTISGHKLGISDVAWSS--DS 99 H + + G LA+ S+D+ +KI+ +G + GH+ + VAW+ Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 100 NLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNF--NPQSNLIVSGSFDESVRI 155 N+L S S D+ + IW +G + GH + V + + ++ GS D ++ + Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 156 --------WDVKTGKCLKTLPAHSDPVSAVHFNR---DGSLI--------------VSSS 190 W+VK K AH+ +AV + GSLI S Sbjct: 132 LTYTGEGQWEVK-----KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGG 186 Query: 191 YDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPN----GKYILAATLDNTLKLW--D 242 D L ++W K ++ + V V ++P+ I + + D + +W D Sbjct: 187 CDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 + HK ++S+T VSG DN V +W Sbjct: 247 DASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGG-DNKVTLW 289 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 94/237 (39%), Gaps = 29/237 (12%) Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKT--LPAHSDPVSAVHFNR-- 181 H + + + + + S D SV+I+DV+ G + L H PV V + Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLID-DDNPPVSFVKFSPN--GKYILAATLDNTL 238 G+++ S SYD IW +G K+ + V+ V ++P+ G + + D + Sbjct: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 Query: 239 KLWDYS-KGKCLKTYTGHKNEKYCIFANFS----------------VTGGKWIVSGSEDN 281 L Y+ +G+ + + C +++ K SG DN Sbjct: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDN 189 Query: 282 LVYIWNLQ---TKEIVQKLQGHTDVVISTACHPTENIIAS--AALENDKTIKLWKSD 333 L+ +W + + QKL+ H+D V A P+ + S A+ D + +W D Sbjct: 190 LIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 Score = 81.2 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 45/198 (22%), Positives = 75/198 (37%), Gaps = 33/198 (16%) Query: 35 YALKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKI--WGAYDGKFEKTI-SGHKLG 89 + AGH +V+SV ++P G LA S+D I + + K I + H +G Sbjct: 93 WEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIG 152 Query: 90 ISDVAWSSDS-----------------NLLVSASDDKTLKIWDVSSG---KCLKTLKGHS 129 + V+W+ S D +K+W K + L+ HS Sbjct: 153 CNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHS 212 Query: 130 NYVFCCNFNPQ----SNLIVSGSFDESVRIW---DVKTGKCL-KTLPAHSDPVSAVHFNR 181 ++V + P ++ I S S D V IW D + K L +D V V ++ Sbjct: 213 DWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSI 272 Query: 182 DGSLIVSSSYDGLCRIWD 199 +++ S D +W Sbjct: 273 TANILAVSGGDNKVTLWK 290 Score = 70.0 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 46/130 (35%), Gaps = 5/130 (3%) Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT--YTGHKNEKYC 261 + T+ + + G + + D ++K++D G + GH+ + Sbjct: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ--GHTDVVISTACHPTENIIASA 319 + A G + S S D V IW + + + GH V S P + + A Sbjct: 63 V-AWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILA 121 Query: 320 ALENDKTIKL 329 +D I L Sbjct: 122 CGSSDGAISL 131 >6EM1-m nrPDB Length = 807 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 46/233 (19%), Positives = 93/233 (39%), Gaps = 18/233 (7%) Query: 25 QSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK---LIKIWGAYDGKFEK 81 +KP+ + + T++ K V + + G++ + D + I + Sbjct: 575 WNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQS 633 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 K I D + L S + ++I+D+S +K L + ++ + +P+ Sbjct: 634 PFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRG 692 Query: 142 NLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 + +++ SFD+ V D+ KTL H V +V+F++ L S++ DG ++ Sbjct: 693 DNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 752 Query: 201 ASGQ---------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLW 241 LK L ++ V + P ++ +A DNT +LW Sbjct: 753 TVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 97.4 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 118/346 (34%), Gaps = 56/346 (16%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--- 78 S +P P++ AGH V ++ P+G WLA+ S D +++W G+ Sbjct: 418 SPKDLRPFPIR----CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVY 473 Query: 79 FEKTISGHKLG---ISDVAWSSDSN---LLVSASDDKTLKI-----WDVSSGKCLKTLKG 127 I + I + W+ D+N L V+ ++ L + +D+ + K G Sbjct: 474 RTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDG 533 Query: 128 HSNYVFC------CNFNPQSNLIVSGSFDE-----------SVRIWDVKTGKCLK----- 165 F N + G D V W+ + K L+ Sbjct: 534 FGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICI 589 Query: 166 TLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 T+ V + ++R G V+ S + I S ++ + KF Sbjct: 590 TISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQV-SKHLTQSPFKKSKGIIMDAKF 647 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 P + + ++++D S+ +K I + G I S S D Sbjct: 648 HPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKI--DIHPRGDNLIAS-SFDKR 703 Query: 283 VYIWNLQ-TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 V +L + L+ H V S H + +SAA +D TI Sbjct: 704 VLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAA--DDGTI 747 Score = 94.3 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 80/233 (34%), Gaps = 20/233 (8%) Query: 72 WGAYDGK-FEKTI---SGHKLGISDVAWSSDSNLLVSA---SDDKTLKIWDVSSGKCLKT 124 W K EK I K + ++W + V+ S + ++ I VS Sbjct: 575 WNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP 634 Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184 K + F+P + S VRI+D+ +K L + +S + + G Sbjct: 635 FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGD 693 Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--- 241 +++SS+D D + V V F +A D T+ ++ Sbjct: 694 NLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT 753 Query: 242 ---DYSKGKCL---KTYTGHK--NEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 D K + K TGHK N + A + W+ S DN +W Sbjct: 754 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWH-PREAWLFSAGADNTARLW 805 Score = 86.2 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 38/196 (19%), Positives = 70/196 (35%), Gaps = 18/196 (9%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 P S T V + + + KF P L S + ++I+ Sbjct: 613 QPDSGNTSVLIHQVSKHLT-QSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQ 670 Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW-DVS-SGKCLKTLKGHSNYVFCC 135 K + +S + + L+++S DK + +W D+ + KTL+ H V Sbjct: 671 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSV 729 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGK---------CLKTLPAH----SDPVSAVHFNRD 182 NF+ + L S + D ++ ++ LK L H S V ++ Sbjct: 730 NFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPR 789 Query: 183 GSLIVSSSYDGLCRIW 198 + + S+ D R+W Sbjct: 790 EAWLFSAGADNTARLW 805 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 79/218 (36%), Gaps = 24/218 (11%) Query: 132 VFCCNFNPQSNLIVSG---SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 V +++ + + V+ S + SV I V + F+ + Sbjct: 597 VKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 656 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 S RI+D + +K L+ +S + P G ++A++ D + D Sbjct: 657 CSQ-RYVRIYDLSQQILVKKLLPGA-RWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAST 714 Query: 249 L-KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE---------IVQKLQ 298 KT H+ + + + S ++D +++++ + ++KL Sbjct: 715 PYKTLRYHEKAVRSVNFHKKLP---LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLT 771 Query: 299 GHTDV----VISTACHPTENIIASAALENDKTIKLWKS 332 GH + V+ HP E + SA D T +LW + Sbjct: 772 GHKVINSLGVLDAIWHPREAWLFSAGA--DNTARLWTT 807 >6C0F-s nrPDB Length = 807 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 46/233 (19%), Positives = 93/233 (39%), Gaps = 18/233 (7%) Query: 25 QSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK---LIKIWGAYDGKFEK 81 +KP+ + + T++ K V + + G++ + D + I + Sbjct: 575 WNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQS 633 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 K I D + L S + ++I+D+S +K L + ++ + +P+ Sbjct: 634 PFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRG 692 Query: 142 NLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 + +++ SFD+ V D+ KTL H V +V+F++ L S++ DG ++ Sbjct: 693 DNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 752 Query: 201 ASGQ---------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLW 241 LK L ++ V + P ++ +A DNT +LW Sbjct: 753 TVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 96.6 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 118/346 (34%), Gaps = 56/346 (16%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--- 78 S +P P++ AGH V ++ P+G WLA+ S D +++W G+ Sbjct: 418 SPKDLRPFPIR----CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVY 473 Query: 79 FEKTISGHKLG---ISDVAWSSDSN---LLVSASDDKTLKI-----WDVSSGKCLKTLKG 127 I + I + W+ D+N L V+ ++ L + +D+ + K G Sbjct: 474 RTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDG 533 Query: 128 HSNYVFC------CNFNPQSNLIVSGSFDE-----------SVRIWDVKTGKCLK----- 165 F N + G D V W+ + K L+ Sbjct: 534 FGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICI 589 Query: 166 TLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 T+ V + ++R G V+ S + I S ++ + KF Sbjct: 590 TISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQV-SKHLTQSPFKKSKGIIMDAKF 647 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 P + + ++++D S+ +K I + G I S S D Sbjct: 648 HPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKI--DIHPRGDNLIAS-SFDKR 703 Query: 283 VYIWNLQ-TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 V +L + L+ H V S H + +SAA +D TI Sbjct: 704 VLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAA--DDGTI 747 Score = 93.9 bits (232), Expect = 9e-20, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 80/233 (34%), Gaps = 20/233 (8%) Query: 72 WGAYDGK-FEKTI---SGHKLGISDVAWSSDSNLLVSA---SDDKTLKIWDVSSGKCLKT 124 W K EK I K + ++W + V+ S + ++ I VS Sbjct: 575 WNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP 634 Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184 K + F+P + S VRI+D+ +K L + +S + + G Sbjct: 635 FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGD 693 Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--- 241 +++SS+D D + V V F +A D T+ ++ Sbjct: 694 NLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT 753 Query: 242 ---DYSKGKCL---KTYTGHK--NEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 D K + K TGHK N + A + W+ S DN +W Sbjct: 754 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWH-PREAWLFSAGADNTARLW 805 Score = 85.8 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 38/196 (19%), Positives = 70/196 (35%), Gaps = 18/196 (9%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 P S T V + + + KF P L S + ++I+ Sbjct: 613 QPDSGNTSVLIHQVSKHLT-QSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQ 670 Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW-DVS-SGKCLKTLKGHSNYVFCC 135 K + +S + + L+++S DK + +W D+ + KTL+ H V Sbjct: 671 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSV 729 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGK---------CLKTLPAH----SDPVSAVHFNRD 182 NF+ + L S + D ++ ++ LK L H S V ++ Sbjct: 730 NFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPR 789 Query: 183 GSLIVSSSYDGLCRIW 198 + + S+ D R+W Sbjct: 790 EAWLFSAGADNTARLW 805 Score = 79.3 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 79/218 (36%), Gaps = 24/218 (11%) Query: 132 VFCCNFNPQSNLIVSG---SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 V +++ + + V+ S + SV I V + F+ + Sbjct: 597 VKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 656 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 S RI+D + +K L+ +S + P G ++A++ D + D Sbjct: 657 CSQ-RYVRIYDLSQQILVKKLLPGA-RWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAST 714 Query: 249 L-KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE---------IVQKLQ 298 KT H+ + + + S ++D +++++ + ++KL Sbjct: 715 PYKTLRYHEKAVRSVNFHKKLP---LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLT 771 Query: 299 GHTDV----VISTACHPTENIIASAALENDKTIKLWKS 332 GH + V+ HP E + SA D T +LW + Sbjct: 772 GHKVINSLGVLDAIWHPREAWLFSAGA--DNTARLWTT 807 >5WLC-LN nrPDB Length = 776 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 57/308 (18%), Positives = 119/308 (38%), Gaps = 34/308 (11%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS--GHKLGISDVAWSS---D 98 H ++ K +P+ LA ++ I+IW + F++ + G I + WS+ + Sbjct: 53 HKSNIN--KLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGE 110 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 S L S + WD+++G L+ +S ++ + N + + G + +V + D+ Sbjct: 111 SLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDI 170 Query: 159 KTG----KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-----DTASGQCLKTL 209 G + L V + + +D ++ DG RIW D G+ L T+ Sbjct: 171 SGGPGVLEHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKNDENMGRLLHTM 229 Query: 210 IDD----DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265 D ++ V V + P I + ++K WD+ +++ H + C+ Sbjct: 230 KVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLT-- 287 Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIV----------QKLQGHTDVVISTACHPTENI 315 + T ++ S D ++ ++ T + + L G+ I + Sbjct: 288 -TDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADF 346 Query: 316 IASAALEN 323 + S +E Sbjct: 347 LVSGGVEK 354 Score = 96.6 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 112/307 (36%), Gaps = 34/307 (11%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG----KFEKTISGHKLGISDVAWSSDS 99 ++ + S+ + + + L+ + + + G + + + + + +AW D Sbjct: 140 NSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDD 199 Query: 100 NLLVSASDDKTLKIW-----DVSSGKCLKTLKGHSN-----YVFCCNFNPQSNLIVSGSF 149 ++ S D ++IW D + G+ L T+K V+ + P+++ I SG Sbjct: 200 FVIGGCS-DGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDS 258 Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT- 208 S++ WD + ++ AH V + + D + + S+ D + + + K Sbjct: 259 TGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNN 318 Query: 209 --------LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260 L+ ++ S ++++ ++ TL + + E Y Sbjct: 319 RWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPY 378 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE-------IVQKLQGHTD-VVISTACHPT 312 N V + +V ++ V IW + T +V KL D + + + P Sbjct: 379 --SKNVLVNKEQRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPD 436 Query: 313 ENIIASA 319 ++ Sbjct: 437 GQVLVVG 443 Score = 27.7 bits (60), Expect = 7.1, Method: Composition-based stats. Identities = 45/268 (16%), Positives = 96/268 (35%), Gaps = 39/268 (14%) Query: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF 79 + S+T+ V K TL + +S+ SP+G+ L K++ Sbjct: 406 TDSSTEQNYKLV-----CKLTLK-DDQNISTCSLSPDGQVLVVGRPSTT-KVFHLQPVGN 458 Query: 80 EKTISGHKLGI------SDVAWSSDSNLLVSASDDKTLKIWDVSSGK-------CLKTLK 126 + ++ + V + +S +++ + +D + D+ S + L + Sbjct: 459 KLKVTKLDNDLLLRTSTKLVKFIDNSKIVICSCEDDVFIV-DLESEEDEKPQEVELLEVT 517 Query: 127 GHSNYVFCCNFNPQSNL-----IVSGSFD-ESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 + + N ++L I S V I D+K + K L ++ ++AVH N Sbjct: 518 STKSSIKVPYINRINHLEVDQNIAVISRGCGVVDILDLK-ARISKPLARLNNFITAVHIN 576 Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240 +V + D ++ L + ++++ ++S N DN K Sbjct: 577 TSRKSVVVITADNKIYEFNMN----LNSEAENEDSESVLTQWSKNNT-------DNLPKE 625 Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSV 268 W K C+ ++ +N F + Sbjct: 626 WKTLKENCVGIFSDIENSSRLWFWGATW 653 >6CB1-s nrPDB Length = 569 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 46/233 (19%), Positives = 93/233 (39%), Gaps = 18/233 (7%) Query: 25 QSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK---LIKIWGAYDGKFEK 81 +KP+ + + T++ K V + + G++ + D + I + Sbjct: 337 WNKPSQKQLEKDICITISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQS 395 Query: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141 K I D + L S + ++I+D+S +K L + ++ + +P+ Sbjct: 396 PFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRG 454 Query: 142 NLIVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200 + +++ SFD+ V D+ KTL H V +V+F++ L S++ DG ++ Sbjct: 455 DNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHA 514 Query: 201 ASGQ---------CLKTLIDD---DNPPVSFVKFSPNGKYILAATLDNTLKLW 241 LK L ++ V + P ++ +A DNT +LW Sbjct: 515 TVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 118/346 (34%), Gaps = 56/346 (16%) Query: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK--- 78 S +P P++ AGH V ++ P+G WLA+ S D +++W G+ Sbjct: 180 SPKDLRPFPIR----CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVY 235 Query: 79 FEKTISGHKLG---ISDVAWSSDSN---LLVSASDDKTLKI-----WDVSSGKCLKTLKG 127 I + I + W+ D+N L V+ ++ L + +D+ + K G Sbjct: 236 RTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDG 295 Query: 128 HSNYVFC------CNFNPQSNLIVSGSFDE-----------SVRIWDVKTGKCLK----- 165 F N + G D V W+ + K L+ Sbjct: 296 FGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICI 351 Query: 166 TLPAHSDPVSAVHFNRDGSLIVSS---SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 T+ V + ++R G V+ S + I S ++ + KF Sbjct: 352 TISC-KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQV-SKHLTQSPFKKSKGIIMDAKF 409 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 P + + ++++D S+ +K I + G I S S D Sbjct: 410 HPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKI--DIHPRGDNLIAS-SFDKR 465 Query: 283 VYIWNLQ-TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 V +L + L+ H V S H + +SAA +D TI Sbjct: 466 VLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAA--DDGTI 509 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 80/233 (34%), Gaps = 20/233 (8%) Query: 72 WGAYDGK-FEKTI---SGHKLGISDVAWSSDSNLLVSA---SDDKTLKIWDVSSGKCLKT 124 W K EK I K + ++W + V+ S + ++ I VS Sbjct: 337 WNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP 396 Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184 K + F+P + S VRI+D+ +K L + +S + + G Sbjct: 397 FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGD 455 Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--- 241 +++SS+D D + V V F +A D T+ ++ Sbjct: 456 NLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT 515 Query: 242 ---DYSKGKCL---KTYTGHK--NEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 D K + K TGHK N + A + W+ S DN +W Sbjct: 516 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWH-PREAWLFSAGADNTARLW 567 Score = 85.4 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 37/195 (18%), Positives = 68/195 (34%), Gaps = 16/195 (8%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 P S T V + + + KF P L S + ++I+ Sbjct: 375 QPDSGNTSVLIHQVSKHLT-QSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQ 432 Query: 78 KFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS-SGKCLKTLKGHSNYVFCCN 136 K + +S + + L+++S DK + D+ + KTL+ H V N Sbjct: 433 ILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVN 492 Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGK---------CLKTLPAH----SDPVSAVHFNRDG 183 F+ + L S + D ++ ++ LK L H S V ++ Sbjct: 493 FHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE 552 Query: 184 SLIVSSSYDGLCRIW 198 + + S+ D R+W Sbjct: 553 AWLFSAGADNTARLW 567 Score = 79.3 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 79/218 (36%), Gaps = 24/218 (11%) Query: 132 VFCCNFNPQSNLIVSG---SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188 V +++ + + V+ S + SV I V + F+ + Sbjct: 359 VKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV 418 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 S RI+D + +K L+ +S + P G ++A++ D + D Sbjct: 419 CSQ-RYVRIYDLSQQILVKKLLPGA-RWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAST 476 Query: 249 L-KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE---------IVQKLQ 298 KT H+ + + + S ++D +++++ + ++KL Sbjct: 477 PYKTLRYHEKAVRSVNFHKKLP---LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLT 533 Query: 299 GHTDV----VISTACHPTENIIASAALENDKTIKLWKS 332 GH + V+ HP E + SA D T +LW + Sbjct: 534 GHKVINSLGVLDAIWHPREAWLFSAGA--DNTARLWTT 569 >5WLC-LW nrPDB Length = 554 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 41/192 (21%), Positives = 82/192 (42%), Gaps = 6/192 (3%) Query: 50 SVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDK 109 S + N ++ A + I+ +G + H + + LLV+A + Sbjct: 156 SATYLQNEQYFAVAQKKYTF-IYDH-EGTELHRLKQHIEA-RHLDFLPYHYLLVTAGETG 212 Query: 110 TLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169 LK DVS+G+ + L+ + NP + ++ G + +V +W + L L + Sbjct: 213 WLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLS 272 Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 PV+++ +R G + ++ D +IWD + + L ++ + P + V S G + Sbjct: 273 ARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSV-ESLPTPGTNVSISDTG--L 329 Query: 230 LAATLDNTLKLW 241 LA + + LW Sbjct: 330 LALSRGPHVTLW 341 Score = 86.6 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 90/245 (36%), Gaps = 8/245 (3%) Query: 7 KPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSAD 66 +PE E + S +S N AL +L +K++ NG L + Sbjct: 75 EPENELEKTFKV-QQSEIKSSVDVSTANKALDLSLK--EFGPYHIKYAKNGTHLLITGRK 131 Query: 67 KLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK 126 + G+ + ++ + + A K I+D G L LK Sbjct: 132 GHVASMDWRKGQLRAELFLNETC-HSATYLQNEQYFAVAQK-KYTFIYDHE-GTELHRLK 188 Query: 127 GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI 186 H +F P L+V+ ++ DV TG+ + L + P A+ N +++ Sbjct: 189 QHIEA-RHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVM 247 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG 246 +G +W + + L L+ PV+ + +G Y+ D ++K+WD Sbjct: 248 HLGHSNGTVSLWSPSMPEPLVKLL-SARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNF 306 Query: 247 KCLKT 251 K L + Sbjct: 307 KQLHS 311 Score = 59.3 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 13/111 (11%), Positives = 43/111 (38%), Gaps = 2/111 (1%) Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105 ++ +P + ++ + +W + + + ++ +A + + Sbjct: 233 GPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATT 292 Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 D+++KIWD+ + K L +++ + + +++ S V +W Sbjct: 293 GADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTG--LLALSRGPHVTLW 341 Score = 58.1 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 35/217 (16%), Positives = 66/217 (30%), Gaps = 10/217 (4%) Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 DVS+ L + + ++ V D + G+ L + Sbjct: 96 DVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNE-TC 154 Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 + + ++ + I+D G L L + F P ++ A Sbjct: 155 HSATYLQNEQYFAVA-QKKYTFIYDHE-GTELHRLKQH--IEARHLDFLPYHYLLVTAGE 210 Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294 LK D S G+ + + N G + V +W+ E + Sbjct: 211 TGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHL---GHSNGTVSLWSPSMPEPL 267 Query: 295 QKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 KL V S A + +A+ D+++K+W Sbjct: 268 VKLLSARGPVNSIAIDRSGYYMATTGA--DRSMKIWD 302 >3JZG-A nrPDB Length = 402 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 62/391 (15%), Positives = 136/391 (34%), Gaps = 76/391 (19%) Query: 3 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTL-------AGHTKAVSSVKFS- 54 T ++P+T TP++ +S + K++ H + + V+F+ Sbjct: 9 TNTERPDTPTN----TPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNW 64 Query: 55 ---PNGEWLASSSADKLIKIWGAYDGKFEKTISGH-----KLGISDVAWSSDSN----LL 102 + ++ + ++ + + + + AW+ DSN LL Sbjct: 65 HSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLL 124 Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTG 161 A ++I + + +C+K GH N + F+P NL++S S D ++R+W+++T Sbjct: 125 AVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD 184 Query: 162 KCLKTL---PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD------ 212 + H D V + ++ G I+S D ++W S + + + + Sbjct: 185 TLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPN 244 Query: 213 ---------------------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK---- 247 V V++ G IL+ + +N + W K + Sbjct: 245 KTNRPFISQKIHFPDFSTRDIHRNYVDCVRW--LGDLILSKSCENAIVCWKPGKMEDDID 302 Query: 248 -------CLKTYTGHKNEKYCIFANFSVTG--GKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 + + I+ K + G++ +Y+W+L+ ++ Sbjct: 303 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDP----- 357 Query: 299 GHTDVVISTACHPTENIIASAALENDKTIKL 329 H + H I + D +I + Sbjct: 358 -HKAKCTTLTHHKCGAAIRQTSFSRDSSILI 387 Score = 58.9 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 28/144 (19%), Positives = 58/144 (40%), Gaps = 13/144 (9%) Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGK----YILAATLDNTLKLWDYSKGKCLKTYTGH-- 255 S +C+ +L +D N P+ V+F+ + K + A N + L++ ++ + Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 256 ----KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 +N C + S T + ++ I N T + ++ GH + + HP Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 161 Query: 312 -TENIIASAALENDKTIKLWKSDC 334 N++ S + D ++LW Sbjct: 162 RDPNLLLSVS--KDHALRLWNIQT 183 >5CXB-B nrPDB Length = 369 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 66/377 (17%), Positives = 116/377 (30%), Gaps = 85/377 (22%) Query: 28 PTPVKPNYALKFT-LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-G 85 P +KP ++ T GH V SV P G LA+ D +++W G+ ++ Sbjct: 3 PDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLN 62 Query: 86 HKLGISDVAWSSDSNLL---VSASDDKTLKIW---------DVSSGKCLKTLKGHS---- 129 ++ V W + +A +D L I D +S L GH+ Sbjct: 63 GDEAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGK 122 Query: 130 ----------------------------------NYVFCCNFNPQSNLIVSGSFDESVRI 155 + + +++ + + + S Sbjct: 123 QQANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQ--- 179 Query: 156 WDVKTGKCLKTLPAHSDPV---------SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206 ++ + TL H + F+ L ++ R +D + + Sbjct: 180 ---RSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELV 235 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266 K + +S P G ++ + D L LW T + + F Sbjct: 236 KIVQPGA-KWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRF 293 Query: 267 SVTGGKWIVSGSEDNLVYIW-------NLQTKEIV--QKLQGHTDV----VISTACHPTE 313 G S+D + I+ L+ IV + L+GH V V+ HP E Sbjct: 294 HKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPRE 353 Query: 314 NIIASAALENDKTIKLW 330 SA D T +LW Sbjct: 354 PWCVSAGA--DGTARLW 368 Score = 41.9 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 19/39 (48%), Gaps = 2/39 (5%) Query: 293 IVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 +GH V S A PT +A+ +D T+++W+ Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGG--DDGTVRVWE 49 Score = 37.3 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 12/67 (17%), Positives = 20/67 (29%), Gaps = 7/67 (10%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHT----KAVSSVKFSPNGEWLASSSA 65 ++ Q P + L GH V + + P W S+ A Sbjct: 305 SDDGSLQIFHGKVPNDQLENPTIVPVKM---LKGHKVVNKLGVLDIDWHPREPWCVSAGA 361 Query: 66 DKLIKIW 72 D ++W Sbjct: 362 DGTARLW 368 >4E5Z-B nrPDB Length = 436 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 105/271 (38%), Gaps = 31/271 (11%) Query: 43 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGH---KLGISDVAWSSD 98 G +++ +KF+P N +SS + ++ G + + + + S+ Sbjct: 162 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSAS 220 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWD 157 S ++V+ + + + ++ GK L L+ H V NP + + + S D++V+IWD Sbjct: 221 SRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 279 Query: 158 VK----TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD- 212 ++ L +LP H PV+A F+ DG+ ++++ R++ + C LI Sbjct: 280 LRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 338 Query: 213 -----DNPPVSFVKFSPNGKYILAATLD-----------NTLKLWDYSKGKCLKTYTGHK 256 P+ ++ D T+ ++D + GK + + Sbjct: 339 HRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPE 398 Query: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 + F+ G + + IW+ Sbjct: 399 SSGISSLNEFNPMGDTLASAMGY--HILIWS 427 Score = 76.6 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 98/264 (37%), Gaps = 19/264 (7%) Query: 71 IWGAYDGKFEKTISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSGKCLKTLKG-- 127 + + + + + +AW + + S + +W+ +KG Sbjct: 103 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG 162 Query: 128 HSNYVFCCNFNP-QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS----AVHFNRD 182 + FNP +N + S + + R+ D K G L+ A SD ++ ++ + Sbjct: 163 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVF-ASSDTINIWFCSLDVSAS 220 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLW 241 ++V+ G + + + + V+ V +P + LA A++D T+K+W Sbjct: 221 SRMVVTGDNVGNVILLNMDGKEL--WNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIW 278 Query: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301 D + + ++ ++ + A G +++ + + + +++ + L H Sbjct: 279 DLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHP 338 Query: 302 DV------VISTACHPTENIIASA 319 I A HP N+I Sbjct: 339 HRHFQHLTPIKAAWHPRYNLIVVG 362 Score = 63.5 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 71/181 (39%), Gaps = 6/181 (3%) Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLID- 211 + + + + L+ +++ ++ S + S G +W+ + Sbjct: 102 FLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGI 161 Query: 212 DDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270 ++ +KF+P N A++++ T +L D+ KG L+ + + Sbjct: 162 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSAS 220 Query: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330 + +V+G V + N+ KE+ L+ H V A +P + A D+T+K+W Sbjct: 221 SRMVVTGDNVGNVILLNMDGKELW-NLRMHKKKVTHVALNPCCDWF-LATASVDQTVKIW 278 Query: 331 K 331 Sbjct: 279 D 279 >5K19-A nrPDB Length = 569 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 43/265 (16%), Positives = 87/265 (32%), Gaps = 29/265 (10%) Query: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL 88 + N LK+T+ A++ FSP+G++LA S D ++++ + T+ + Sbjct: 206 SKSTRNPLLKWTVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG 263 Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 G+ V WS D +V+ +D + +W + + GH ++V F+P + + Sbjct: 264 GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYT----TSV 319 Query: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAV------HFNRDG------SLIVSSSYDGLCR 196 + + L D ++ + D S D Sbjct: 320 EEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLC 379 Query: 197 IWDTAS----GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 +WD + ++ P G + T + ++ Sbjct: 380 LWDLTEDILFPHQPLSRARTHTNVMNATS-PPAGSNGNSVTTPG-----NSVPPPLPRSN 433 Query: 253 TGHKNEKYCIFANFSVTGGKWIVSG 277 + + + SV G I SG Sbjct: 434 SLPHSAVSNAGSKSSVMDG-AIASG 457 Score = 96.6 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 78/237 (32%), Gaps = 36/237 (15%) Query: 45 TKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDG-----------KFEKTISGHK----- 87 V+ VK+ P E + + + ++ K ++ + H Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 88 ------------LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135 +++ A+S D L S D L++++ S + T+K + + C Sbjct: 209 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCV 268 Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLI-------VS 188 ++P IV+G D+ V +W + + H VS V F+ + + S Sbjct: 269 CWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFS 328 Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 S + + + T + + + D L LWD ++ Sbjct: 329 GSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 385 Score = 78.9 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 40/223 (17%), Positives = 89/223 (39%), Gaps = 27/223 (12%) Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG----HSNYVFCCNFNP-QSNLIVSGSFD 150 +++S L+ +++ D + K + V C + P +L + Sbjct: 112 TAESVSLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSS 171 Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFN--RDGSLIVSSSYDGLCRIWDTASGQCLKT 208 ++ +++V+ H+ +A H+ + G C+ T + T Sbjct: 172 GNMYLYNVE----------HTCGTTAPHYQLLKQGESFAV----HTCKSKSTRNPLLKWT 217 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 + + ++ FSP+GK++ + D L+++++ + T + C+ + Sbjct: 218 VGEG---ALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS--- 271 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 GK+IV+G ED+LV +W+ ++ + GH V A P Sbjct: 272 PDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314 Score = 54.2 bits (129), Expect = 7e-08, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 58/172 (33%), Gaps = 32/172 (18%) Query: 193 GLCRIWDTASGQCLKTLIDD---DNPPVSFVKFSP-NGKYILAATLDNTLKLWD------ 242 G ++ D + K ++ D V+ VK+ P + L A + L++ Sbjct: 125 GQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCG 184 Query: 243 --------YSKGKCLKTYTGHKNEKYCIFANFSV-----------TGGKWIVSGSEDNLV 283 +G+ +T ++V GK++ S+D + Sbjct: 185 TTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFL 244 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK-SDC 334 ++N + E+ ++ + ++ P I + D + +W DC Sbjct: 245 RVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGG--EDDLVTVWSFVDC 294 >5M89-A nrPDB Length = 329 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 94/220 (42%), Gaps = 13/220 (5%) Query: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120 A D + I+ K E+T+ + ++ W+ +V + +K++D +G+ Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGE-PVTATEWT--GTKVVIGTAKGWVKVYD--AGR 121 Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180 T + H+ V +P ++ S D+S +D++TG+ + A ++ F+ Sbjct: 122 ESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA-DAALTTCAFH 180 Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL-DNTLK 239 DG+L + + G ++ T + + ++ P+ + FS NG + A +++ Sbjct: 181 PDGNLFAAGTQTGHILVFHTTTLEQAESFPLG--TPIQALAFSENGFWFAATGKGTSSVT 238 Query: 240 LWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 ++D K G E I +++ G+++ +G Sbjct: 239 IFDLRKSGAAAAVKELQTGEVLSISWDYT---GQYLATGG 275 Score = 90.5 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 90/233 (38%), Gaps = 15/233 (6%) Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 + ++ D L I+ V + K +TL V + +V G+ V Sbjct: 58 SLDLENECAAVGGLDGKLDIYSVVANKVERTLDI-GEPVTATEW--TGTKVVIGTAKGWV 114 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213 +++D G+ T H+ PV+ + + G ++ S D +D +G+ + D Sbjct: 115 KVYDA--GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYAD- 171 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273 ++ F P+G A T + ++ + + +++ + FS G + Sbjct: 172 -AALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQ---ALAFSENGFWF 227 Query: 274 IVSGSEDNLVYIWNLQTK---EIVQKLQGHTDVVISTACHPTENIIASAALEN 323 +G + V I++L+ V++LQ T V+S + T +A+ Sbjct: 228 AATGKGTSSVTIFDLRKSGAAAAVKELQ--TGEVLSISWDYTGQYLATGGGTG 278 Score = 87.8 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 32/207 (15%), Positives = 79/207 (38%), Gaps = 9/207 (4%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWS 96 T H V+ + P G LAS DK + G+ + G+ ++ A+ Sbjct: 123 SATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGE--RVARGYADAALTTCAFH 180 Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI-VSGSFDESVRI 155 D NL + + + ++ ++ + ++ + + F+ +G SV I Sbjct: 181 PDGNLFAAGTQTGHILVFHTTTLEQAESFPLGT-PIQALAFSENGFWFAATGKGTSSVTI 239 Query: 156 WDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG-LCRIWDTASGQCLKTLIDDD 213 +D++ +G + V ++ ++ G + + G +++ A+ + + Sbjct: 240 FDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRLG- 298 Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKL 240 PV VK+ K ++ + + + + Sbjct: 299 -MPVVGVKWGGEAKRLVVVSREGVVSV 324 >5BJS-A nrPDB Length = 605 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 37/167 (22%), Positives = 73/167 (43%), Gaps = 23/167 (13%) Query: 56 NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS-DSNLLVSASDDKTLKIW 114 + L + + +K++ +GK +T+ GH GI+D+A S + ++ SASDD T++IW Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 Query: 115 DVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK--- 165 ++ C+ +GHS + F+ ++S D+ + +W + Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEI 266 Query: 166 ----------TLPAHSDPVSAVHFNRDGSLIVS-SSYDGLCRIWDTA 201 + H++ V V F G LI+S + ++ +W Sbjct: 267 PIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLWRIE 311 Score = 83.1 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 83/200 (41%), Gaps = 28/200 (14%) Query: 157 DVKTGKCLKTLPAHSDPVSAVH-FNRDG----SLIVSSSYDGLCRIWDTASGQCLKTLID 211 D + ++ + + + +++D L+ + +G ++++ G+ +TL+ Sbjct: 117 DANPCEIIQLIRDDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLV- 175 Query: 212 DDNPPVSFVKFSPNGKYI-LAATLDNTLKLWDYSKGK----CLKTYTGHKNEKYCIFANF 266 ++ + SP YI +A+ D T+++W + C+ G + + F Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 267 SVTGGKWIVSGSEDNLVYIWNL-----QTKEI--------VQKLQGHTDVVISTACHPTE 313 G++++S D ++ +W L + EI + H ++V A + Sbjct: 236 H-DNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY--G 292 Query: 314 NIIASAALENDKTIKLWKSD 333 ++I S A D TI LW+ + Sbjct: 293 DLILSRACHED-TIVLWRIE 311 Score = 83.1 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 66/177 (37%), Gaps = 24/177 (13%) Query: 15 AQPTPSSSATQSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIW 72 QP + + L TL GH ++ + SP + +AS+S D I+IW Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 Query: 73 GAYDGKFEKTI------SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG------K 120 ++ GH + VA+ + ++SA D+ + +W + Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEI 266 Query: 121 CLKTLKG-------HSNYVFCCNFNPQSNLIVS-GSFDESVRIWDVKTGKCLKTLPA 169 + H+N V C F +LI+S ++++ +W ++ +P Sbjct: 267 PIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLWRIEGFSSDDPIPG 321 >3JB9-S nrPDB Length = 488 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 45/198 (22%), Positives = 93/198 (46%), Gaps = 12/198 (6%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVS 104 + V+ ++ P+GE+L ++S +K I+ + T++ H I+ +A D NL V+ Sbjct: 295 DEKVNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFVA 350 Query: 105 ASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKC 163 ++ L+ ++ SSG L HS+ V F L+V+ + D + IWD++ + Sbjct: 351 GLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSEL 410 Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL---CRIWDTASGQCLKTLIDDDNPPVSFV 220 ++ +P + V+AV + L+VSS + L + + S +C+ +S + Sbjct: 411 VQKIPLQTK-VAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCM---SQTHVSSISNL 466 Query: 221 KFSPNGKYILAATLDNTL 238 + +L +T + + Sbjct: 467 VWLNELHQLLFSTSNGAI 484 Score = 77.0 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 97/230 (42%), Gaps = 18/230 (7%) Query: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 S +++ V L D+ S LK +G C + S + V+ + S+ Sbjct: 218 SPENSSFVLCLHKDELLCLDIQSNSTLKIFEG---SALACCWLTSSKIAVATADAISIFE 274 Query: 156 WDVKT------GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 + V + G+ ++P V+ + + G ++++S + C I+ S T+ Sbjct: 275 FPVSSSGLQSVGEPTSSIPIDEK-VNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNITV 332 Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269 ++ + P+G +A + L+ ++ S G L + H + F Sbjct: 333 AQH----ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVK--TLQFGEN 386 Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319 G +V+ ++D+ ++IW+L+ E+VQK+ T V + + T ++ S+ Sbjct: 387 GYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTK-VAAVSLDITSQLLVSS 435 Score = 57.7 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 74/198 (37%), Gaps = 20/198 (10%) Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 S+ ++ DE + + D+++ LK A + + V+++ I++ Sbjct: 221 NSSFVLCLHKDELLCL-DIQSNSTLKIFEG---SALACCWLTSSKIAVATAD--AISIFE 274 Query: 200 TA-SGQCLKTLIDDDNPP-----VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 253 S L+++ + + V+F++ P+G+Y+LAA+ + ++ T Sbjct: 275 FPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNITVA 333 Query: 254 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTE 313 H I + G V+G E+ + + + + K H+ V + Sbjct: 334 QH------ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENG 387 Query: 314 NIIASAALENDKTIKLWK 331 + +D I +W Sbjct: 388 YWLV-VTTNDDSDIFIWD 404 Score = 46.9 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 22/112 (19%), Positives = 49/112 (43%), Gaps = 3/112 (2%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKL-IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102 H+ V +++F NG WL ++ D I IW + + I ++ V+ S LL Sbjct: 374 HSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTK-VAAVSLDITSQLL 432 Query: 103 VSA-SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153 VS+ + + I+ SS + H + + + + + ++ + + ++ Sbjct: 433 VSSDGETLYVHIYVKSSKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAI 484 >4PSX-B nrPDB Length = 401 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 116/270 (42%), Gaps = 29/270 (10%) Query: 86 HKLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNL 143 H+ I+ + D N++ + + T ++ S G TLK H + + +F+ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGR 175 Query: 144 IVSGSFDESVRIWDVKTG----KCLKTL-PAHSDPVSAVHFNR-DGSLIVSSSYDGLCRI 197 ++SGS D +V +W+V +G K ++T HSD ++ ++ + L + S D L +I Sbjct: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 Query: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGK-YILAATLDNTLKLWDYSKG-KCLKTYTGH 255 D + + P + + FS + + AA +D+ + L+D + L +GH Sbjct: 236 NDVRANNTTIDTVKCPQ-PFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGH 294 Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT--------------KEIVQKLQGHT 301 ++ + FS +VS DN + +W+L+ E++ GH Sbjct: 295 EDAVNNLE--FSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHR 352 Query: 302 DVVISTACHPTENIIASAALENDKTIKLWK 331 V +P + A+ E + +++WK Sbjct: 353 SSVNDFDLNPQIPWLV-ASAEEENILQVWK 381 Score = 94.7 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 52/235 (22%), Positives = 95/235 (40%), Gaps = 28/235 (11%) Query: 36 ALKFTLAGHTKAVSSVKFSP--NGEWLASSSADKLIKIWGAYD-GKFEKTISG----HKL 88 L+ TL H ++ FS G L S S D + +W G K + H Sbjct: 151 GLQSTLKFHKDNGYALSFSTLVKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDLHSD 209 Query: 89 GISDVAWSS-DSNLLVSASDDKTLKIWDVS-SGKCLKTLKGHSNYVFCCNF-NPQSNLIV 145 I+D W + + +L + S+D LKI DV + + T+K + F + SNL+ Sbjct: 210 IINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPF-NTLAFSHHSSNLLA 268 Query: 146 SGSFDESVRIWDVKT-GKCLKTLPAHSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTASG 203 + D V ++D++ + L + H D V+ + F+ ++VSS D +WD Sbjct: 269 AAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQI 328 Query: 204 QCLKT-------------LIDDDNPPVSFVKFSPNGKYILAATLDNTL-KLWDYS 244 +T + V+ +P +++A+ + + ++W S Sbjct: 329 GAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 >5A9Q-7 nrPDB Length = 360 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 55/323 (17%), Positives = 111/323 (34%), Gaps = 67/323 (20%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG---KFEKTISGHKLGISDVAWSSD-- 98 H + V F +G +A+ S+D+ +K+W + + H + V W+ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF------------CCNFNPQ--SNLI 144 +L S S D+T +W+ G+ L+G S++V F P+ ++ Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 145 VSGSFDESVRIW------DVKTGKCLKTLPAHSDPVSAVHFNRDGS-----LIVSSSYDG 193 + S D VRI+ ++ + S + +N S +I S D Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLS-CSCISWNPSSSRAHSPMIAVGSDDS 189 Query: 194 ------LCRIWDTASGQCLKTLIDDD---NPPVSFVKFSPNG----KYILAATLDNTLKL 240 +I++ + PV + F+PN + AT D +++ Sbjct: 190 SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRI 247 Query: 241 WDYSKG---------------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285 + + + H ++ + + N + G + S +D V + Sbjct: 248 FTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT---GTVLASSGDDGCVRL 304 Query: 286 WN---LQTKEIVQKLQGHTDVVI 305 W + + L+G+ V Sbjct: 305 WKANYMDNWKCTGILKGNGSPVN 327 Score = 92.8 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 113/302 (37%), Gaps = 58/302 (19%) Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYVFCCNF-NPQ- 140 HK I DV++ + + S D+++K+WD S C + K HS V+ + +P+ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP------------VSAVHFNRD--GSLI 186 ++ S SFD + +W+ G+ L S V+ V F G ++ Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS----FVKFSP-----NGKYILAATLDNT 237 + S DG+ RI++ L + ++P + I + D++ Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 238 ------LKLWDYSKGKCLKT-----YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 +++++Y++ T FA + ++D V I+ Sbjct: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIF 248 Query: 287 NLQTKE---------------IVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 L+ IV + H V + + T ++AS+ +D ++LWK Sbjct: 249 TLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSG--DDGCVRLWK 306 Query: 332 SD 333 ++ Sbjct: 307 AN 308 Score = 70.4 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 50/238 (21%), Positives = 96/238 (40%), Gaps = 47/238 (19%) Query: 26 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTI 83 + + ++ + TL +V+ VKF+P G LA+ SAD +++I+ A D Sbjct: 94 NDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQW 153 Query: 84 S-----GHKLGISDVAWSSDSN-----LLVSASDDKT------LKIWDVSSGKCLK---- 123 S KL S ++W+ S+ ++ SDD + ++I++ + Sbjct: 154 SLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAE 213 Query: 124 TLKGHSNYVFCCNFNPQS----NLIVSGSFDESVRIWDVK---------------TGKCL 164 TL ++ V F P +++ + D VRI+ +K + Sbjct: 214 TLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIV 271 Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD---TASGQCLKTLIDDDNPPVSF 219 H+ V V +N G+++ SS DG R+W + +C ++ + PV+ Sbjct: 272 AQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCT-GILKGNGSPVNG 328 Score = 62.3 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 52/141 (36%), Gaps = 16/141 (11%) Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKYCIF 263 +++ D + V F +G+ + + D ++K+WD S+ C ++ H + + Sbjct: 5 RSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVT 64 Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV------------VISTACHP 311 G+ + S S D +W E KL+G + V P Sbjct: 65 -WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123 Query: 312 TENIIASAALENDKTIKLWKS 332 + A D ++++++ Sbjct: 124 KHMGLMLATCSADGIVRIYEA 144 Score = 42.7 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 28/77 (36%), Gaps = 3/77 (3%) Query: 19 PSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY--- 75 P S P K + H V V ++ G LASS D +++W A Sbjct: 252 PVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMD 311 Query: 76 DGKFEKTISGHKLGISD 92 + K + G+ ++ Sbjct: 312 NWKCTGILKGNGSPVNG 328 >3W15-A nrPDB Length = 368 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 68/368 (18%), Positives = 133/368 (36%), Gaps = 77/368 (20%) Query: 37 LKFTLAGHTKAVSSVKFSP--NGEW-LASSSADKLI---KIWGAYDGKFEKTISGH---- 86 L++ + G + V++SP + +A+ S L+ K++ + + + + Sbjct: 4 LRYHMQGFSG--YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT 61 Query: 87 KLGISDVAWSSDS-NLLVSASDDKTLKIWDVSSGK-CLKTLKGHSNYVFCCNFNPQSNL- 143 + + D+AW+ N ++ A D TL+++D + + + K H VF CN+N + Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQN 121 Query: 144 IVSGSFDESVRIWDVKTGKCLKTL---------------------------PAHSDPVSA 176 +S S+D S++IW + L TL + + V Sbjct: 122 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 181 Query: 177 VHFNR-DGSLIVSSSYDGLCRIWDTA--SGQCLKTLIDDDNPPVSFVKFSPNGKYILA-A 232 F+ D +L++S S + ++D SG+ + F+ Y++A Sbjct: 182 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATG 241 Query: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCI------------FANFSVTGGKWIVSGSED 280 +DN +++WD + L G + CI +S ++S S D Sbjct: 242 GVDNAIRIWDI---RMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYD 298 Query: 281 NLVYIW-NLQ---------------TKEIVQKLQGHTDVVISTACHPTENIIASAALEND 324 IW +L TK + H++ V A+ D Sbjct: 299 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWD 358 Query: 325 KTIKLWKS 332 + +W Sbjct: 359 GNLFVWNG 366 >6F1U-h nrPDB Length = 612 Score = 94.7 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 48/266 (18%), Positives = 97/266 (36%), Gaps = 31/266 (11%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK------TISGHKLGISDVAW--SSDSN 100 + KF PN + + I +W K + + H + V + +++ Sbjct: 313 TFAKFHPN--LVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAH 370 Query: 101 LLVSASDDKTLKIWDVS-------SGKCLKTLKGHSNYVFCCNFNPQSNL--IVSGSFDE 151 L+S S D + W + S + + + + V +F P ++ V GS + Sbjct: 371 NLISISTDGKICSWSLDMLSHPQDSMELVHK-QSKAVAVTSMSF-PVGDVNNFVVGSEEG 428 Query: 152 SV--RIWDVKTGKCLKTLPAHSDPVSAVHFN------RDGSLIVSSSYDGLCRIWDTASG 203 SV + H P++ +H + L V+SS+D ++W T + Sbjct: 429 SVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNN 488 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLD-NTLKLWDYSKGKCLKTYTGHKNEKYCI 262 + L + +D+ V V +SP + A L LW+ + + T + + Sbjct: 489 KPLYSF-EDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPAL 547 Query: 263 FANFSVTGGKWIVSGSEDNLVYIWNL 288 G+ I G + + I+++ Sbjct: 548 NRVRWTHSGREIAVGDSEGQIVIYDV 573 Score = 91.2 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 94/246 (38%), Gaps = 25/246 (10%) Query: 21 SSATQSKPTPVKPNYALKFTLAGHTKAVSSVKF--SPNGEWLASSSADKLIKIWGA---- 74 +K TPV+ + A HT V V + N L S S D I W Sbjct: 334 WDNRSNKRTPVQRTP---LSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLS 390 Query: 75 --YDGKFEKTISGHKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSSGKCLKT---LKGH 128 D + ++ +++ D N V S++ ++ G +GH Sbjct: 391 HPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSV-YTACRHGSKAGISEMFEGH 449 Query: 129 SNYVFCCNFNPQ------SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR- 181 + + + S+L V+ SFD +V++W K K L + ++ V V ++ Sbjct: 450 QGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPT 509 Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKT--LIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239 +L G +W+ + + T + + NP ++ V+++ +G+ I + + Sbjct: 510 HPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIV 569 Query: 240 LWDYSK 245 ++D + Sbjct: 570 IYDVGE 575 Score = 88.1 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 55/292 (18%), Positives = 111/292 (38%), Gaps = 37/292 (12%) Query: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD----------DKTLKIWDVSSGKCL 122 F++ S H++ +S + WSS L+ AS D +W++ K Sbjct: 240 SLNRQFFDERWSKHRV-VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTT 298 Query: 123 KTLKGH-SNYVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLP----AHSD 172 H + V F+P NL+V G++ + +WD ++ K ++ P AH+ Sbjct: 299 PEYVFHCQSAVMSATFAKFHP--NLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTH 356 Query: 173 PVSAVHF--NRDGSLIVSSSYDGLCRIWDT---ASGQCLKTLIDDDNPPV--SFVKFSP- 224 PV V+ ++ ++S S DG W + Q L+ + V + + F Sbjct: 357 PVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVG 416 Query: 225 NGKYILAATLDNTLKLW--DYSKGKCLKTYTGHKNEKYCIFANFSV---TGGKWIVSGSE 279 + + + + ++ SK + + GH+ I + +V V+ S Sbjct: 417 DVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSF 476 Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 D V +W+ + + + + + V PT + + ++ + LW Sbjct: 477 DWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFAC-VDGMGRLDLWN 527 >3I2N-A nrPDB Length = 357 Score = 92.8 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 44/347 (12%), Positives = 117/347 (33%), Gaps = 52/347 (14%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLAS----SSADKLIKIWGAYDGKFEKTISGHK 87 + + G V K+ P + + +I+++ G + K Sbjct: 5 EKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK 64 Query: 88 -LGISDVAW---SSDSNLLVSASDDKTLKIWDVSSGK-CLKTLKGHSNYVFCCNFNPQ-- 140 I + S L + L IW++ + + + ++KGH + + Sbjct: 65 AKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLG 124 Query: 141 ----SNLIVSGSFDESVRIWDVKTG-KCLKTLP----AHSDPVSAVHF----NRDGSLIV 187 + IV+GS D +V++WD + + + + V F N++ ++ Sbjct: 125 IGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVC 184 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP---NGKYILAATLDNTLKLWDYS 244 + +G +++D + L+ + N V ++F + ++A +L+ ++D Sbjct: 185 AGYDNGDIKLFDLRN-MALRWETNIKN-GVCSLEFDRKDISMNKLVATSLEGKFHVFDMR 242 Query: 245 KGKCLKTYTGHKNEKYCIFAN---FSVTGGKWIVSGSEDNLVYIWNLQ------------ 289 K + + + + ++ +++W + Sbjct: 243 TQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEG 302 Query: 290 -------TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329 + ++Q + T + S P + + + D+T+++ Sbjct: 303 IEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSF-DQTVRV 348 Score = 50.4 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 24/143 (16%), Positives = 52/143 (36%), Gaps = 14/143 (9%) Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL----DNTLKLWDYSKGKCLKTYTGHK 256 Q + + N V K+ P + ++L++ G K Sbjct: 5 EKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK 64 Query: 257 NEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTEN 314 + C + +++ +G ++IWNL+ E+ V ++GH +++ + Sbjct: 65 AKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLG 124 Query: 315 I------IASAALENDKTIKLWK 331 I I + + D T+K+W Sbjct: 125 IGEGAPEIVTGS--RDGTVKVWD 145 >3F3P-A nrPDB Length = 351 Score = 91.6 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 59/341 (17%), Positives = 119/341 (34%), Gaps = 63/341 (18%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSS 97 +GH V V + G +A+ S+D+ IK++ + + + H I + W+S Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 98 --DSNLLVSASDDKTLKIW--DVSSGKC-------LKTLKGHSNYVFCCNFNPQ--SNLI 144 ++ SAS DKT+K+W D +C L TL ++ F P + Sbjct: 68 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 127 Query: 145 VSGSFDESVRIW------DVKTGKCLKTLPA-------HSDPVSAVHFNRD----GSLIV 187 D +R++ D+++ + H + + L V Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 187 Query: 188 SS---------SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP----NGKYILAATL 234 S+ DG + + + + ++P + I Sbjct: 188 SALEQAIIYQRGKDGKLHV---------AAKLPGHKSLIRSISWAPSIGRWYQLIATGCK 238 Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK--- 291 D ++++ ++ L ++ + S S+ N LQ+ Sbjct: 239 DGRIRIFKITEK--LSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQV 296 Query: 292 EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 E++ + H V S + + T I++SA +D ++LWK+ Sbjct: 297 ELLSEHDDHNGEVWSVSWNLTGTILSSAG--DDGKVRLWKA 335 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 50/300 (16%), Positives = 103/300 (34%), Gaps = 45/300 (15%) Query: 27 KPTPVKPNYALKFTLAGHTKAVSSVKF-SP-NGEWLASSSADKLIKIW--GAYDGKFEK- 81 K N+ L + H ++ ++ + SP G +AS+S DK +K+W + Sbjct: 39 KLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGR 98 Query: 82 ------TISGHKLGISDVAWSSD--SNLLVSASDDKTLKIWDVSSGKCLKTLK------- 126 T++ K + V ++ L +D L+++D L++ Sbjct: 99 RWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKV 158 Query: 127 ------GHSNYVFCCNFNPQS---NLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVS 175 H FC ++ P + + ++++ K GK LP H + Sbjct: 159 LSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIR 218 Query: 176 AVHFNRD----GSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVS----FVKFSPNG 226 ++ + LI + DG RI+ L + N + V G Sbjct: 219 SISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQG 278 Query: 227 KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 + + NT + + ++ + H + +++ G + S +D V +W Sbjct: 279 R-----SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 333 Score = 60.8 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 39/238 (16%), Positives = 75/238 (31%), Gaps = 70/238 (29%) Query: 40 TLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTI-------------S 84 TL ++ SVKF+P G LA D +++++ A + ++ + Sbjct: 105 TLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPA 164 Query: 85 GHKLGISDVAWSSD---SNLLVSASDDKTLKIWDVSSGKCL--KTLKGHSNYVFCCNFNP 139 H ++W L ++ ++ + GK L GH + + ++ P Sbjct: 165 NHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAP 224 Query: 140 QSN----LIVSGSFDESVRIWDVKTG---------------------------------- 161 LI +G D +RI+ + Sbjct: 225 SIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT 284 Query: 162 ------------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207 + L H+ V +V +N G+++ S+ DG R+W K Sbjct: 285 EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 342 Score = 46.9 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 41/87 (47%), Gaps = 11/87 (12%) Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW----NLQTKEIVQKLQGHTDVVISTA 308 +GH + + + +F G+ + + S D + ++ + E+ + H +++ Sbjct: 8 SGHDDLVHDVVYDFY---GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 64 Query: 309 C-HPT-ENIIASAALENDKTIKLWKSD 333 P IIASA+ DKT+KLW+ D Sbjct: 65 WASPEYGRIIASASY--DKTVKLWEED 89 >5A9Q-2 nrPDB Length = 326 Score = 91.2 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 39/260 (15%), Positives = 86/260 (33%), Gaps = 25/260 (9%) Query: 44 HTKAVSSVKFSPNGEW--------LASSSADKLIKIW--GAYDGKFEKTISGHKLGISDV 93 H V + +SP +S+AD I+++ D K + GH I+ + Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGL 130 Query: 94 AWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDE 151 + + + S SDD T +IW++ G HS ++P+ ++ + Sbjct: 131 VFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFKLMVAEKNG 188 Query: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211 ++R +D+ + + +L + P+ + H+ + V + IWD + Sbjct: 189 TIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQNKRP 248 Query: 212 DDNPPVSFVKFS-PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK----YCIFANF 266 ++S + + + + GH + + Sbjct: 249 VHMDRACLFRWSTISENLFATTGYPGKM------ASQFQIHHLGHPQPILMGSVAVGSGL 302 Query: 267 SVTGGKWIVSGSEDNLVYIW 286 S + D+ + W Sbjct: 303 SWHRTLPLCVIGGDHKLLFW 322 Score = 83.1 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 83/218 (38%), Gaps = 21/218 (9%) Query: 120 KCLKTLKGHSNYVFCCNFNPQSNL--------IVSGSFDESVRIW--DVKTGKCLKTLPA 169 K L+T H V ++P++ L + + D +R++ D++ K L Sbjct: 64 KTLRTFH-HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEG 122 Query: 170 HSDPVSAVHFNRD-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228 H+D ++ + F+ G I S S D CRIW+ Q ++ P V + P + Sbjct: 123 HTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLH---SPGMSVCWHPEETF 179 Query: 229 -ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 ++ A + T++ +D + + + + T V+G N IW+ Sbjct: 180 KLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAG---NDWLIWD 236 Query: 288 L-QTKEIVQKLQGHTDVVISTACHP-TENIIASAALEN 323 + ++ K H D +EN+ A+ Sbjct: 237 ITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPG 274 Score = 82.7 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 85/240 (35%), Gaps = 22/240 (9%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKL 68 T AA + +S Q K L GHT ++ + F P G+ +AS S D Sbjct: 97 TSAADMKIRLFTSDLQDK--------NEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHT 148 Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKTLKIWDVSSGKCLKTLKG 127 +IW +G H G V W + L+ A + T++ +D+ + + + +L+ Sbjct: 149 CRIWNL-EGVQTAHFVLHSPG-MSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLES 206 Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDV-KTGKCLKTLPAHSDPVSAVHFNR-DGSL 185 + ++ ++ V IWD+ ++ P H D ++ +L Sbjct: 207 EQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENL 266 Query: 186 IVSSSYDGLC----RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 ++ Y G +I Q + S + + + D+ L W Sbjct: 267 FATTGYPGKMASQFQIHHLGHPQPILM---GSVAVGSGLSWHRTLPLCVIGG-DHKLLFW 322 Score = 64.6 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 38/228 (16%), Positives = 81/228 (35%), Gaps = 32/228 (14%) Query: 129 SNYVFCCNFNP-----QSNLIVSGSFDESVRIW--------DVK--TGKCLKTLPAHSDP 173 +YV FNP NLI G + V DV+ K L+T H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFH-HGVR 74 Query: 174 VSAVHFNRDGSL--------IVSSSYDGLCRIW-DTASGQCLKTLIDDDNPPVSFVKFSP 224 V + ++ + L +S+ D R++ + +++ ++ + F P Sbjct: 75 VDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDP 134 Query: 225 -NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283 G+ I + + D+T ++W+ +G + H + + ++ ++ + Sbjct: 135 KEGQEIASVSDDHTCRIWNL-EGVQTAHFVLHSP---GMSVCWHPEETFKLMVAEKNGTI 190 Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 ++L ++ + L+ ++S A ND I W Sbjct: 191 RFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLI--WD 236 Score = 48.5 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 32/73 (43%), Gaps = 3/73 (4%) Query: 263 FANFSVTGGKWIVSGSEDNLVYIW--NLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320 S+ + + D + ++ +LQ K + L+GHTD + P E A+ Sbjct: 84 TRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEI-AS 142 Query: 321 LENDKTIKLWKSD 333 + +D T ++W + Sbjct: 143 VSDDHTCRIWNLE 155 >5A9Q-0 nrPDB Length = 380 Score = 87.8 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 93/248 (37%), Gaps = 23/248 (9%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW-------GAYDGKFEKTISGHKLGIS----- 91 H V ++F + E + ++S+ + ++ + T H S Sbjct: 73 HHGDVMDLQFF-DQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSS 131 Query: 92 --DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGS 148 ++ +V+ +D + ++ + ++T+ S+ + F ++ S Sbjct: 132 APCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNS 191 Query: 149 FDESVRIWDVKTG----KCLKTLPAHSDPVSAVHFNRDG-SLIVSSSYDGLCRIWDTASG 203 ++IWD + + +L P+ V + + ++ + DG+ IWD G Sbjct: 192 I-GQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQG 250 Query: 204 QCLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262 +L+ + V F P N +++ + D +L WD S K+ H+ + Sbjct: 251 TMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSST 310 Query: 263 FANFSVTG 270 F + S++ Sbjct: 311 FLSHSISN 318 Score = 84.3 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 40/265 (15%), Positives = 92/265 (34%), Gaps = 39/265 (14%) Query: 102 LVSASDDK---TLKIW---DVSSGKCLKTLKG---------HSNYVFCCNFNPQSNLIVS 146 + S D + +W D + +G H V F Q ++ + Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAA 91 Query: 147 GSFDE-SVRIWDVKTGKCL-----KTLPAHSDP-------VSAVHFNRDGSLIVSSSYDG 193 S +V + T H+ P + IV+ DG Sbjct: 92 SSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDG 151 Query: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK----GKCL 249 ++ + ++T+ + D+ + V F + + ++ LK+WD+ + + Sbjct: 152 RINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGNEPSQI 210 Query: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTA 308 + TG + +C+ + + +G +D ++ IW+++ + V L+ H + Sbjct: 211 LSLTGDRVPLHCV--DRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVH 268 Query: 309 CHP-TENIIASAALENDKTIKLWKS 332 HP + + + D ++ W + Sbjct: 269 FHPSNPEHLFTCS--EDGSLWHWDA 291 Score = 78.9 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 105/286 (36%), Gaps = 39/286 (13%) Query: 60 LASSSADKL---IKIWGAYDGKFEKTISG------------HKLGISDVAWSSDSNLLVS 104 A+ S D I +W D + G H + D+ + D +V+ Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQF-FDQERIVA 90 Query: 105 ASDDKTLKIW-------DVSSGKCLKTLKGHSNYVF-------CCNFNPQSNLIVSGSFD 150 AS + ++ +S + T H+ C + IV+ D Sbjct: 91 ASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGED 150 Query: 151 ESVRIWDVKTGKCLKTLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS--GQCLK 207 + ++ + ++T+ A S + AV F R ++ + + G +IWD + + Sbjct: 151 GRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEIL-TVNSIGQLKIWDFRQQGNEPSQ 209 Query: 208 TL-IDDDNPPVSFVKFSPNGKYILA-ATLDNTLKLWDYSKGKC-LKTYTGHKNEKYCIFA 264 L + D P+ V PN ++++A D L +WD +G + H+ E + + Sbjct: 210 ILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVH- 268 Query: 265 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310 F + + + + SED ++ W+ T + H ST Sbjct: 269 -FHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLS 313 >3EI3-B nrPDB Length = 383 Score = 87.4 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 55/351 (15%), Positives = 129/351 (36%), Gaps = 34/351 (9%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEW-LASSSADKL 68 + ++ Q +Y L T + + V+S+++ P +A S Sbjct: 38 SSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGD 97 Query: 69 IKIWGAYDGKFEKTISGHKLG---ISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKT 124 I +W YD + + + I+ + ++ ++N L +S + D SG ++ Sbjct: 98 IILWD-YDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLFVSSIRGATTLRDF-SGSVIQV 155 Query: 125 LKGHSNYVF---CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 181 ++ + C + + ++ +G + + + + K H V+ FN Sbjct: 156 FAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKE-KLHKAKVTHAEFNP 214 Query: 182 DGSLI-VSSSYDGLCRIWDTASGQCLKTLIDD--DNPPVSFVKFSP-NGKYILAATLDNT 237 + +SS D ++WD + + + I + PV+ F+P + +L N Sbjct: 215 RCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNE 274 Query: 238 LKLWDYSKGKCLKTYTGHKNEKYC----IFANFSVTGGKWIVSG---------SEDNLVY 284 ++++ H + ++ I A + IV+G ++ + Sbjct: 275 IRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYD-LIVAGRYPDDQLLLNDKRTID 333 Query: 285 IWNLQTKEIVQKL--QGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 I++ + +V +L ++ PT +++AS N I +W + Sbjct: 334 IYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFN---ILIWNRE 381 >5LTD-A nrPDB Length = 525 Score = 84.3 bits (207), Expect = 7e-17, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 88/212 (41%), Gaps = 33/212 (15%) Query: 67 KLIKIWGA--YDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT 124 + +KI E T G I V + + + ++T+ I+D+++ + L T Sbjct: 99 RRLKIINTKRQTTICELTFPG---AILAVKLNRER---LVVLLEETIYIYDINNMRLLHT 152 Query: 125 LKGHSNYVFCCNFNPQS--NLIVSGS---------------------FDESVRIWDVKTG 161 ++ SN +P S N + S + V I+D KT Sbjct: 153 IETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTL 212 Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL-CRIWDTASGQCLKTLIDDDNP-PVSF 219 + + AH ++A+ ++DG L+ ++S G R++ A+G L P + Sbjct: 213 QPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYS 272 Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251 + FSP+ ++++A++ T+ ++ + + T Sbjct: 273 LAFSPDNRFVIASSATETVHIFRLGEEEAANT 304 Score = 68.1 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 63/145 (43%), Gaps = 19/145 (13%) Query: 28 PTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK 87 P + PN + TL + + V + + I+ A + I H+ Sbjct: 179 PQKLAPNPQTEVTLHSNPQTVR----------------NGDVIIFDAKTLQPTSVIEAHR 222 Query: 88 LGISDVAWSSDSNLLVSASDDKT-LKIWDVSSGKCLKTLKGHSNY--VFCCNFNPQSNLI 144 ++ +A S D LL +ASD T ++++ V++G L + + ++ F+P + + Sbjct: 223 TSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFV 282 Query: 145 VSGSFDESVRIWDVKTGKCLKTLPA 169 ++ S E+V I+ + + T+ + Sbjct: 283 IASSATETVHIFRLGEEEAANTIKS 307 Score = 52.3 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 45/299 (15%), Positives = 105/299 (35%), Gaps = 39/299 (13%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVAWSSDSNLLV 103 ++ F+ + S KI+ G+ G +GI ++ +SS +V Sbjct: 31 NDNINFANFNQDFS-CVSVGYSNGYKIYNCEPFGQCYSKSDG-SIGIVEMLFSSSLLAIV 88 Query: 104 SASDDKTL-----KIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 + +L KI + + L + N + +++ +E++ I+D+ Sbjct: 89 GMGEQHSLSPRRLKIINTKRQTTICELTFP-GAILAVKLNRERLVVL---LEETIYIYDI 144 Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 + L T+ S N +G + +S S + + + P + Sbjct: 145 NNMRLLHTIETPS--------NPNGLIALSPSSENNYLAYPSPQKLAPN--------PQT 188 Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278 V N + + + + ++D + H+ I + G + + S Sbjct: 189 EVTLHSNPQTV----RNGDVIIFDAKTLQPTSVIEAHRTSLAAIALS---KDGLLLATAS 241 Query: 279 EDNLV-YIWNLQTKEIVQKLQGHTDV--VISTACHPTEN-IIASAALENDKTIKLWKSD 333 + + ++++ T + + + T + S A P +IAS+A E +L + + Sbjct: 242 DKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEE 300 >5MC6-j nrPDB Length = 397 Score = 82.7 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 36/151 (23%), Positives = 63/151 (41%), Gaps = 28/151 (18%) Query: 26 SKPTPVKP--NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83 S+ + ++P N+ + ++ ++ ++ SVKFSP G LA + Y+ +F + I Sbjct: 212 SELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERI 271 Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143 +L + SS L HS++V +FN Sbjct: 272 -------------------------GSLSVPTHSSQASLGEF-AHSSWVMSLSFNDSGET 305 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174 + S +D +R WDVKT + + TL H D + Sbjct: 306 LCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Score = 71.6 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 31/141 (21%), Positives = 64/141 (45%), Gaps = 23/141 (16%) Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG------HSNYVFCCNFNPQSNLI 144 + V S L+ + ++ T++I ++S+ + L + +SN + F+PQ +L+ Sbjct: 190 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLL 248 Query: 145 VSGSFDES---VRIWDVKTGKCLKTLP-------------AHSDPVSAVHFNRDGSLIVS 188 S + +++ + G+ + +L AHS V ++ FN G + S Sbjct: 249 AIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCS 308 Query: 189 SSYDGLCRIWDTASGQCLKTL 209 + +DG R WD + + + TL Sbjct: 309 AGWDGKLRFWDVKTKERITTL 329 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 108/327 (33%), Gaps = 67/327 (20%) Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWG--AYDGKFEKTIS----GHKLGISDVAW 95 H + SV S + S S D +K+W D + K S HK G+ V Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 96 -------SSDSNLLVSASDDKTLKIWDVSSGKCLKT------------LKGHSNYVFCCN 136 + + L+ + S L + ++ K +K HS + Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 137 FNPQ---SNLIVSGSFDESVRIWDVK-----------TGKCLKTLPA-------HSDPVS 175 + S+ +V+ + IW L S + Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 176 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN-----PPVSFVKFSPNGKYIL 230 +V + G LI + +G +I + ++ + L + + VKFSP G + Sbjct: 191 SVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLA 249 Query: 231 AATLDNT---LKLWDYSKGKCLKTYTGHKNEK----------YCIFANFSVTGGKWIVSG 277 A N+ + L++ G+ + + + + + + G+ + S Sbjct: 250 IAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSA 309 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVV 304 D + W+++TKE + L H D + Sbjct: 310 GWDGKLRFWDVKTKERITTLNMHCDDI 336 >2P9P-C nrPDB Length = 372 Score = 81.2 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 38/222 (17%), Positives = 75/222 (33%), Gaps = 25/222 (11%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD 92 + L H V+ V ++P+ + + D+ +W ++ T+ + Sbjct: 42 WVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARC 101 Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGK----CLKTLKGHSNYVFCCNFNPQSNLIVSGS 148 V W+ + S + + I C K + V +++P S L+ +GS Sbjct: 102 VRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGS 161 Query: 149 FDESVRIWD------------------VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS 190 D RI+ + G+ + + V V F+ +GS + S Sbjct: 162 CDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVS 221 Query: 191 YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 +D + D + TL + P+ V F + A Sbjct: 222 HDSTVCLADADKKMAVATLA-SETLPLLAVTFITESSLVAAG 262 Score = 80.4 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 88/253 (34%), Gaps = 22/253 (8%) Query: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCL--KTLKGHSNYVFCCNFNPQSNLIVS 146 IS AW+ D + ++ + I++ S K + LK H+ V ++ P SN IV+ Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 147 GSFDESVRIWDV--KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI--WDTAS 202 D + +W + +T K + + V + + S + I ++ + Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 203 GQCL-KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDY---------------SKG 246 + K + V + + PN + A + D +++ SK Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIS 306 + + + G + S D+ V + + K V L T +++ Sbjct: 190 PFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLA 249 Query: 307 TACHPTENIIASA 319 +++A+ Sbjct: 250 VTFITESSLVAAG 262 Score = 75.0 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 33/227 (14%), Positives = 73/227 (32%), Gaps = 26/227 (11%) Query: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIV 187 + C +N I + V I++ K + L H+ V+ V + D + IV Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDD-NPPVSFVKFSPNGKYILAATLDNTLKL--WDYS 244 + D +W TL+ N V+++PN K + + + ++ Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQE 128 Query: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN----------------- 287 + + + ++ + +GS D I++ Sbjct: 129 NDWWVCKHIKKPIRSTVLSLDWH-PNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGS 187 Query: 288 -LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333 + E++ + V + +A + +D T+ L +D Sbjct: 188 KMPFGELMFESSSSCGWVHGVCFSANGSRVAWVS--HDSTVCLADAD 232 Score = 55.4 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 70/220 (31%), Gaps = 64/220 (29%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAY------------------DGKFEKTISGHKLG 89 V S+ + PN LA+ S D +I+ AY G+ S Sbjct: 145 VLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGW 204 Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 + V +S++ + + S D T+ + D + TL + + F +S+L+ +G Sbjct: 205 VHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGH- 263 Query: 150 DESVRIW---------------DVKTGKCLKTLPA------------------------- 169 D ++ DV + L A Sbjct: 264 DCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDS 323 Query: 170 -HSDPVSAVHFNRDG----SLIVSSSYDGLCRIWDTASGQ 204 H + VS + G S ++ DG IWD S + Sbjct: 324 LHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRSLE 363 >5TF2-A nrPDB Length = 407 Score = 78.5 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 38/231 (16%), Positives = 75/231 (32%), Gaps = 33/231 (14%) Query: 51 VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKT 110 V F+ + LA+ D +++W + H+ I D+A D LV+ D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLK 236 Query: 111 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV------SGSFDESVRI--------- 155 +W + + + Q+ +G +V+I Sbjct: 237 ASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPP 296 Query: 156 ------WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 WD L+T + VS + + G+ + + G I+ S QCL + Sbjct: 297 PCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYV 356 Query: 210 IDDDNPPVSFVKFSP-----------NGKYILAATLDNTLKLWDYSKGKCL 249 + V+ V F P + + + +D+ +L + + Sbjct: 357 REAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRSV 407 Score = 75.0 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 79/226 (34%), Gaps = 35/226 (15%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 V ++ D+ LL + D +++W V S + + K H + P +V+ D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLK 236 Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD----GLCRIWDTASGQCLKT 208 +W V+ +H+ +G S+ Y ++ D +G L T Sbjct: 237 ASVWQ------------KDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFT 284 Query: 209 LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 + P Y+ A WD S L+T + C+ + S Sbjct: 285 VQIPHKRLRQ-----PPPCYLTA---------WDGSNFLPLRTKSCGHEVVSCLDVSES- 329 Query: 269 TGGKWIVSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVISTACHPTE 313 G ++ G+ V I+ + + + + + H VV A P + Sbjct: 330 --GTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEK 373 Score = 56.6 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 24/70 (34%), Gaps = 3/70 (4%) Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323 + +G D V +W + + E V + + H + A P ++ Sbjct: 177 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVG---R 233 Query: 324 DKTIKLWKSD 333 D +W+ D Sbjct: 234 DLKASVWQKD 243 Score = 55.0 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 27/66 (40%), Gaps = 2/66 (3%) Query: 176 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 235 V FN D +L+ + DG R+W S + + + + P+GK ++ D Sbjct: 177 VVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEF-KAHEGEIEDLALGPDGK-LVTVGRD 234 Query: 236 NTLKLW 241 +W Sbjct: 235 LKASVW 240 Score = 35.4 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 27/58 (46%), Gaps = 2/58 (3%) Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDS 99 GH VS + S +G +L + + I+ A+ + + H + ++DVA+ + Sbjct: 317 GHE-VVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEK 373 >6IYY-A nrPDB Length = 317 Score = 72.7 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 88/240 (36%), Gaps = 26/240 (10%) Query: 58 EWLA-SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 +LA K + IW K I + V D ++V D +K++ Sbjct: 61 NYLALVGGGKKKVMIWDDLKKKTVIEIE-FSTEVKAVKLRRD-RIVVV--LDSMIKVFTF 116 Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVS-----------GSFDESVRIWDV-KTGKCL 164 T H +VF +NP+ ++ G+ V++ D+ T K Sbjct: 117 -------THNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPP 169 Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGL-CRIWDTASGQCLKTLIDDDNPP-VSFVKF 222 +PAH +S + N G+ I ++S G RI+DT+SG ++ L + + F Sbjct: 170 VDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINF 229 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282 + + I ++ T+ ++ K +++ + T +++ D Sbjct: 230 NQDASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGS 289 Score = 57.3 bits (137), Expect = 9e-09, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 48/118 (40%), Gaps = 6/118 (5%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKL-IKIWGAYDGKFEKTIS--GHKLGISDVAWSS 97 + H +S + + G +A++S I+I+ G + + I + ++ Sbjct: 172 IPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQ 231 Query: 98 DSNLLVSASDDKTLKIW---DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152 D++L+ +SD T+ I+ D S + S C F + N +++ D S Sbjct: 232 DASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGS 289 Score = 49.6 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 33/208 (15%), Positives = 71/208 (34%), Gaps = 10/208 (4%) Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 H N + FN G + R+++ K + V V + + Sbjct: 6 HGNGLLYAGFNQDHGCFACGMENGF-RVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLA 64 Query: 188 -SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS-K 245 IWD + + + + + V VK + ++ LD+ +K++ ++ Sbjct: 65 LVGGGKKKVMIWDDLKKKTVIEI--EFSTEVKAVKLRRDRIVVV---LDSMIKVFTFTHN 119 Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQGHTDVV 304 L + N K + G+ V + +L T++ + H V+ Sbjct: 120 PHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVL 179 Query: 305 ISTACHPTENIIASAALENDKTIKLWKS 332 A + IA+A+ E I+++ + Sbjct: 180 SCIALNLQGTRIATAS-EKGTLIRIFDT 206 Score = 32.7 bits (73), Expect = 0.26, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 37/84 (44%), Gaps = 4/84 (4%) Query: 48 VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD---VAWSSDSNLLVS 104 + + F+ + + SS + I+ A D K + + S ++ A+ ++ N +++ Sbjct: 224 IYCINFNQDASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIA 283 Query: 105 ASDDKTLKIWDVS-SGKCLKTLKG 127 D + + + G+C++ + Sbjct: 284 ICADGSYYKFLFNPKGECIRDVYA 307 >5AMS-A nrPDB Length = 431 Score = 71.6 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 102/311 (32%), Gaps = 34/311 (10%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSD 98 HT +V ++ PN + + D L +W ++ KF T++G+ + +++S+ Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF---NPQ-SNLIVSGSFDESVR 154 LV+A + + G L V + +P + G+ D SV Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVW 180 Query: 155 IWDV--KTGKCLKTLPA--HSDPVSAVHF-----NRDGSLIVSSSYDGLCRIWDTASGQC 205 + + + G + + H S F + +V+ S D W+ +GQ Sbjct: 181 CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQ 240 Query: 206 LKTLIDDDNPPVS----FVKFSP------NGKYILAATLDNTLKLWDYSKG-------KC 248 L + + + + +P N + + + L + + + G Sbjct: 241 LFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTV 300 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 ++ I + + + G + +++ + K D V Sbjct: 301 IELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVL-EDSVTKLM 359 Query: 309 CHPTENIIASA 319 ++ AS Sbjct: 360 FDND-DLFASC 369 Score = 65.0 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 77/228 (33%), Gaps = 22/228 (9%) Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK--TLPAHSDPVS 175 S L H++ VF +P L+ +G D +W + TL + + V Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 Query: 176 AVHFNRDGSLIVSSSYDGLCRIWDTASGQ---CLKTLIDDDNPPVSFVKFSPNGKYILAA 232 + F +G +V++ G + G L + + + V + Sbjct: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFG 173 Query: 233 TLDNTL--KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK----WIVSGSEDNLVYIW 286 D ++ + G + +G +++ C F T +V+ S D+ + W Sbjct: 174 ATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAW 233 Query: 287 NLQTKEIV-----QKLQGHTDVVISTACHP------TENIIASAALEN 323 N T + + +++G IS + P ++A + Sbjct: 234 NCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNG 281 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 14/33 (42%), Gaps = 2/33 (6%) Query: 300 HTDVVISTACHPTENIIASAALENDKTIKLWKS 332 HTD V + HP ++ + D LW S Sbjct: 64 HTDSVFAIGHHPNLPLVCTGG--GDNLAHLWTS 94 >6CVZ-A nrPDB Length = 351 Score = 70.4 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 53/264 (20%), Positives = 104/264 (39%), Gaps = 35/264 (13%) Query: 69 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSN-LLVSASDDKTLKIWDVSSGKCLKTLKG 127 +K+ + K + I H I +A+SS LL+SAS D T+K+ + + ++T Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK-TGKCLKTLPAHSD--PVSAVHFN---- 180 CC ++N I +G + S+ ++DV+ T ++ L A P+ ++ + Sbjct: 116 GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAA 175 Query: 181 ----RDGSLIVSSSYDGLC-----------RIWDTASGQCLKTLIDDDNPPVSFVKFSP- 224 G ++ + D + G C+ ++ + V + P Sbjct: 176 SAAFPYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHC-LVTYRPD 234 Query: 225 -NGKYILAATLDNTLKLWDYSKGKC----LKTYTGHKN----EKYCIFANFSVTGGKWIV 275 N I + ++ + +L D C + T+ G K IF + G + Sbjct: 235 KNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVC 294 Query: 276 SGSE-DNLVYIWNLQTKEIVQKLQ 298 +G E N +W+ + ++Q LQ Sbjct: 295 TGDEAANSALLWDAASGSLLQDLQ 318 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 55/316 (17%), Positives = 109/316 (34%), Gaps = 47/316 (14%) Query: 15 AQPTPSSS--ATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKI 71 +QP+P +S N + H K + + FS L S+S D IK+ Sbjct: 42 SQPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKL 101 Query: 72 WGAYDGKFEKTISGHKLGISDVAWSSD-SNLLVSASDDKTLKIWDVSSGKC-LKTLKGHS 129 +T + + + W D +N + + + ++ ++DV + ++ L Sbjct: 102 TSLETNTVVQTYNAGR-PVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQK 160 Query: 130 NYVFCCNFN----------PQSNLIVSGSFDESVRIWD-------------VKTGKCLKT 166 + + P ++ D S W+ ++ G C+ Sbjct: 161 ARCPLVSLSYMPRAASAAFPYGGVLAGTLEDAS--FWEQKMDFSHWPHVLPLEPGGCIDF 218 Query: 167 LPAHSDPVSAVHFNRDGSL--IVSSSYDGLCRIWDTASGQC----LKTLIDDDNPPV--- 217 +S V + D + I S + R+ DT + C + T + Sbjct: 219 QTENSSRHCLVTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTK 278 Query: 218 SFVKFSPNGK-YILAATLD---NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273 + + SP IL T D N+ LWD + G L+ ++ F V + Sbjct: 279 NAIFQSPENDGNILVCTGDEAANSALLWDAASGSLLQDL--QTDQPVLDICPFEVNRNSY 336 Query: 274 IVSGSEDNLVYIWNLQ 289 + + +E +V+I+ + Sbjct: 337 LATLTE-KMVHIYKWE 351 >3DWL-C nrPDB Length = 377 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 83/235 (35%), Gaps = 27/235 (11%) Query: 116 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW--DVKTGKCLKTLPAHSDP 173 +++ + L L S + FN Q V+ + V ++ D K +T H Sbjct: 1 MATSQVLHILPKPS---YEHAFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKI 57 Query: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLKTLIDDD-NPPVSFVKFSPNGKYILA 231 V+ V + + IV+ S D +++ G +TL+ N +FV++SPN Sbjct: 58 VTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAV 117 Query: 232 ATLDNTLKL--WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289 + + + ++ + + + ++ + +G D Y+ + Sbjct: 118 GSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWH-PNNVLLAAGCADRKAYVLSAY 176 Query: 290 TKEIVQKLQG-----------------HTDVVISTACHPTENIIASAALENDKTI 327 +++ K + V + P+ N +A A ++ TI Sbjct: 177 VRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 65.0 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 28/188 (14%), Positives = 69/188 (36%), Gaps = 26/188 (13%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHK--LGIS 91 + T + H K V+ V ++P + + S D+ ++ DG +++T+ + + Sbjct: 45 WKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAAT 104 Query: 92 DVAWSSDSNLLVSASDDKTLKI--WDVSSGKCLKTLKGH--SNYVFCCNFNPQSNLIVSG 147 V WS + + S + + + ++ + + + + +++P + L+ +G Sbjct: 105 FVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAG 164 Query: 148 SFDES----------------VRIW--DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 D +W + P+ V AV F+ G+ + + Sbjct: 165 CADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPS-GGWVHAVGFSPSGNALAYA 223 Query: 190 SYDGLCRI 197 +D I Sbjct: 224 GHDSSVTI 231 >3DW8-B nrPDB Length = 447 Score = 68.1 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 71/413 (17%), Positives = 140/413 (33%), Gaps = 138/413 (33%) Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAY-----------DGKFEKTISGHKLG----- 89 +S+V+F+ +GE LA+ + I+ + T H+ Sbjct: 29 DIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLK 88 Query: 90 -------ISDVAWSSDSN--LLVSASDDKTLKIWDVSSGKC------------------- 121 I+ + W N + +++DKT+K+W +S Sbjct: 89 SLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTT 148 Query: 122 LKTLK---------------------GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV-- 158 + TL+ H+ ++ + N +S D + +W + Sbjct: 149 VTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA-DDLRINLWHLEI 207 Query: 159 --KTGKCLKTLPAHSDP----VSAVHFNRDG-SLIVSSSYDGLCRIWDTASGQCL----- 206 ++ + PA+ + ++A F+ + + V SS G R+ D + Sbjct: 208 TDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSK 267 Query: 207 ----------KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS-KGKCLKTYTGH 255 ++ + +S VKFS +G+Y++ ++K+WD + + + ++TY H Sbjct: 268 LFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPVETYQVH 326 Query: 256 KN---------EKYCIFANFSVT---GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT-- 301 + E CIF F +++GS +N +++ TK + L+ Sbjct: 327 EYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDI-TLEASREN 385 Query: 302 -------------------------------DVVISTACHPTENIIASAALEN 323 ++ TA HP ENIIA A N Sbjct: 386 NKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNN 438 Score = 34.6 bits (78), Expect = 0.064, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 42/117 (35%), Gaps = 22/117 (18%) Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274 +S V+F+ +G+ + + ++ + + H +Y +++ F ++ Sbjct: 29 DIISTVEFNHSGELLATGDKGGRVVIF---QQEQENKIQSHSRGEYNVYSTFQSHEPEF- 84 Query: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331 + ++ L+ + P +N NDKTIKLWK Sbjct: 85 -----------------DYLKSLEIEEK-INKIRWLPQKNAAQFLLSTNDKTIKLWK 123 >5AJA-A nrPDB Length = 361 Score = 63.9 bits (154), Expect = 9e-11, Method: Composition-based stats. Identities = 51/213 (23%), Positives = 88/213 (41%), Gaps = 23/213 (10%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV-SASD 107 + FS +L + +K++ + G+ E + + H I+ + S D +LL+ SA+ Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 108 DKTLK-IWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165 + L +W + S + F+ S V G+ + I+D++TG L Sbjct: 101 SQPLSALWGMKSVFDMKHSFTEDHY----VEFSKHSQDRVIGTKGDIAHIYDIQTGNKLL 156 Query: 166 TL----PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221 TL A++ + FN L++ DG+ +WD S Q + D N +S V Sbjct: 157 TLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWDVRSAQAIHKF-DKFNMNISGV- 209 Query: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254 F PNG ++ T +WD L T Sbjct: 210 FHPNGLEVIINTE-----IWDLRTFHLLHTVPA 237 Score = 62.7 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 78/186 (41%), Gaps = 17/186 (9%) Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV-SSSY 191 CC F+ + ++ G+ +++++V +G+ + H+ ++ + +RDGSL++ S+++ Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 192 DGLCR-IWDTAS-GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249 +W S + +D +V+FS + + + T + ++D G L Sbjct: 101 SQPLSALWGMKSVFDMKHSFTEDH-----YVEFSKHSQDRVIGTKGDIAHIYDIQTGNKL 155 Query: 250 KTYTGHK--NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVIST 307 T N A F+ T + D ++ W++++ + + K + Sbjct: 156 LTLFNPDLANNYKRNCATFNPTDDLVL----NDGVL--WDVRSAQAIHKFDKFNMNISGV 209 Query: 308 ACHPTE 313 HP Sbjct: 210 -FHPNG 214 Score = 57.7 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 42/238 (17%), Positives = 91/238 (38%), Gaps = 33/238 (13%) Query: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV- 145 + G + A+S+ L+ + LK+++V SG+ + H++ + + +L++ Sbjct: 37 ESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLT 96 Query: 146 SGSFDESVR-IWDVKT-GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203 S ++ + + +W +K+ + V F++ V + + I+D +G Sbjct: 97 SATWSQPLSALWGMKSVFDMKHSFTEDHY----VEFSKHSQDRVIGTKGDIAHIYDIQTG 152 Query: 204 QCLKTLID---DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260 L TL + +N + F+P +L D LWD + + + Sbjct: 153 NKLLTLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWDVRSAQAIHKFDKFNMNIS 207 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG---------HTDVVISTAC 309 + F G + I+ IW+L+T ++ + HT V+ A Sbjct: 208 GV---FHPNGLEVII------NTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAM 256 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 7/88 (7%), Positives = 32/88 (36%) Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 +S+ + + + ++ ++++ G+ + ++N+ + + H Sbjct: 21 FSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNS 80 Query: 303 VVISTACHPTENIIASAALENDKTIKLW 330 + +++ ++A + LW Sbjct: 81 AITHLEPSRDGSLLLTSATWSQPLSALW 108 >5WLC-LS nrPDB Length = 594 Score = 61.9 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 52/311 (16%), Positives = 103/311 (33%), Gaps = 43/311 (13%) Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAW-----SSD 98 A+ S+ F P+ L + DK ++I+ ++ I + + + Sbjct: 249 SAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQN 308 Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158 + +A + + WD+S L+ L HS F+ L S S + V Sbjct: 309 QQNIFTAGRRRYMHSWDLS----LENLT-HSQTAKIEKFS---RLYGHESTQRSFENFKV 360 Query: 159 KTGKCLKT--------LPAHSDPVSAVHFNRDGSLIVSSSYDGLC--RIWDTA--SGQCL 206 + +T L ++ ++ +H + G ++ +G+ D S Sbjct: 361 AHLQNSQTNSVHGIVLLQGNNGWINILH-STSGLWLMGCKIEGVITDFCIDYQPISRGKF 419 Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW-DYSKGKCLKTYTGHKNEKYCIFAN 265 +T++ N +F N + ++ W D K G C Sbjct: 420 RTILIAVNAYGEVWEFDLNKN-------GHVIRRWKDQGGVGITKIQVGGGTTTTCPALQ 472 Query: 266 FS-VTGGKWIVSGSEDNLVYIWN------LQTKEIVQKLQGHTDVVISTACHPTENIIAS 318 S + +W+ GSE V +++ T V L T + + P I+ Sbjct: 473 ISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCM 532 Query: 319 AALENDKTIKL 329 A+ ++L Sbjct: 533 ASRAVKDALRL 543 Score = 49.6 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 43/115 (37%), Gaps = 11/115 (9%) Query: 99 SNLLVSASDDKTLKIWD------VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD-- 150 + L S+ + ++D S+ + L + + F+P ++ S Sbjct: 479 NRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVK 538 Query: 151 ESVRIWDVKTGKCLKTLPAHSDP---VSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 +++R+ + + P P V++V F+ G L+ + G R+W Sbjct: 539 DALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 42/115 (36%), Gaps = 10/115 (8%) Query: 140 QSNLIVSGSFDESVRIWD------VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY-- 191 Q+ + GS V ++D T + L + +S + F+ DG ++ +S Sbjct: 478 QNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAV 537 Query: 192 DGLCRIWDTASGQCLKTLIDDDNP--PVSFVKFSPNGKYILAATLDNTLKLWDYS 244 R+ S P V+ V FSP+G + ++LW + Sbjct: 538 KDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 42/126 (33%), Gaps = 7/126 (5%) Query: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT-----LIDDDNPPVSFVKFSPNGK 227 P + + + S G ++D + T +D +S ++FSP+G+ Sbjct: 469 PALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQ 528 Query: 228 YILAATLD--NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285 + A+ + L+L + + + G + G+E V + Sbjct: 529 ILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRL 588 Query: 286 WNLQTK 291 W L Sbjct: 589 WKLNHY 594 Score = 41.9 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 33/110 (30%), Gaps = 14/110 (12%) Query: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF---- 266 + + + F P+ +L D TL+++ + H F Sbjct: 245 HPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSL 304 Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTK----------EIVQKLQGHTDVVIS 306 S + I + ++ W+L + E +L GH S Sbjct: 305 SNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRS 354 Score = 41.1 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 40/100 (40%), Gaps = 12/100 (12%) Query: 24 TQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSA--DKLIKIWGAYDGKFEK 81 T S PTPV L T++ ++FSP+G+ L +S +++ Sbjct: 501 TSSTPTPVAALDQLTTTISN-------LQFSPDGQILCMASRAVKDALRLVHLPSCSVFS 553 Query: 82 TISGHKLG---ISDVAWSSDSNLLVSASDDKTLKIWDVSS 118 ++ VA+S LL ++ +++W ++ Sbjct: 554 NWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 >6N8P-A nrPDB Length = 979 Score = 61.9 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 85/245 (34%), Gaps = 36/245 (14%) Query: 35 YALKFTLA-GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93 + T+ G S++ +SP+ LA + IK++GA +F + ++ + Sbjct: 10 FQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMG-LHQENNAVTQI 68 Query: 94 AWSSDSNLLVSASDDKTLKIWDVS--------SGKCLKTLKGHSNY------VFCCNFNP 139 LV+ DD +L +W + TL+G + + Sbjct: 69 HLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHS 128 Query: 140 QSNLIVSGSFDESVRIWD-----------VKTGKCLKTLPA---HSDP---VSAVHFNR- 181 L+ G+ +V + + + L+ LP H V A+ + Sbjct: 129 SCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPR 188 Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 D + I+ GL IWD + L + + + + +G+ +++ D + W Sbjct: 189 DPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQ--LENIWWQRDGRLLVSCHSDGSYCQW 246 Query: 242 DYSKG 246 S Sbjct: 247 PVSSE 251 Score = 57.7 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 49/308 (15%), Positives = 92/308 (29%), Gaps = 51/308 (16%) Query: 48 VSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106 V +++ P + + + L+ IW + + + ++ W D LLVS Sbjct: 180 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQ-LENIWWQRDGRLLVSCH 238 Query: 107 DDKTLKIWDVSSG----KCLKTLK----GHSNYVFCCNF-------------------NP 139 D + W VSS + L++L + + + Sbjct: 239 SDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASY 298 Query: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 +S D +D + T+ +DP A F+ +L+V + + + D Sbjct: 299 GDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADP--AATFDDPYALVVLAEEE--LVVID 354 Query: 200 TAS----GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD--YSKGKCLKTYT 253 + L L ++ N LKLW+ + G + Sbjct: 355 LQTAGWPPVQLPYLASLHCSAITCSHHVSN----------IPLKLWERIIAAGSRQNAHF 404 Query: 254 GHKNEK--YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 + +++G ED V W+ + + T V T P Sbjct: 405 STMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDP 464 Query: 312 TENIIASA 319 EN A Sbjct: 465 NENFSAQG 472 Score = 49.6 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 30/243 (12%), Positives = 74/243 (30%), Gaps = 34/243 (13%) Query: 116 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 175 K ++ H ++P ++ G+ +++++ G L ++ V+ Sbjct: 10 FQFNKTVEHGFPHQP--SALGYSPSLRILAIGTRSGAIKLY-GAPGVEFMGLHQENNAVT 66 Query: 176 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN-------------PPVSFVKF 222 +H +V+ D +W L +D++ ++ V Sbjct: 67 QIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLP 126 Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTG--------------HKNEKYCIFANFSV 268 + + + T + + + L+ T H+ + A Sbjct: 127 HSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEH 186 Query: 269 T-GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 I+ G LV IW+LQ ++ + + + ++ S +D + Sbjct: 187 PRDPNQILIGYSRGLVVIWDLQGSRVLYHF-LSSQQLENIWWQRDGRLLVSC--HSDGSY 243 Query: 328 KLW 330 W Sbjct: 244 CQW 246 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 41/262 (15%), Positives = 77/262 (29%), Gaps = 39/262 (14%) Query: 52 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTL 111 + S S D + T+ A + D + ++ L Sbjct: 295 RASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADP----AATFDDPYALVVLAEEEL 350 Query: 112 KIWDVSSG-----KCLKTLKGHSNYVFC------CNFNPQSNLIVSGSFDE---SVRIWD 157 + D+ + + H + + C +I +GS S W Sbjct: 351 VVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWP 410 Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217 + G L P D L+++ DG R WD ASG CL+ L V Sbjct: 411 IDGGTSLTPAPPQRD------------LLLTGHEDGTVRFWD-ASGVCLRLLYKLSTVRV 457 Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVTGGKWIVS 276 PN + A D ++ + + ++ + ++ I F ++ Sbjct: 458 FLTDTDPN-ENFSAQGED------EWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAV 510 Query: 277 GSEDNLVYIWNLQTKEIVQKLQ 298 V + L + Q ++ Sbjct: 511 AGTAGQVLVLELNDEAAEQAVE 532 Score = 31.1 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 29/223 (13%), Positives = 75/223 (33%), Gaps = 21/223 (9%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155 +LL++ +D T++ WD +SG CL+ L K + VF + +P N + DE + Sbjct: 422 PQRDLLLTGHEDGTVRFWD-ASGVCLRLLYKLSTVRVFLTDTDPNEN-FSAQGEDEWPPL 479 Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215 V + + + + + + G + + + + + Sbjct: 480 RKVGSFDPYS--DDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEAD 537 Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 + + + A ++ + G + + + + + + ++ +V Sbjct: 538 LLQDQEGYRWKGHERLAARSGPVR---FEPG--FQPFVLVQCQPPAVVTSLALHSEWRLV 592 Query: 276 SGSEDNLVYIWNLQTKEIVQK-----------LQGHTDVVIST 307 + + +++ Q + V L+G V S Sbjct: 593 AFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSL 635 >2I3T-A nrPDB Length = 341 Score = 61.6 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 45/321 (14%), Positives = 122/321 (38%), Gaps = 39/321 (12%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSSDSN 100 +S +K P+ L +S D + ++ + +++ +K + + +++ Sbjct: 11 KDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLLCCNFIDNTD 69 Query: 101 L-LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN-LIVSGSFDESVRIWDV 158 L + + + D+ + L + + C + +++ S+D + + D Sbjct: 70 LQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDP 129 Query: 159 KTGK----CLKTLPAHSDPVSA--VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212 + +K L +++ V + + S ++ + + + + I++ Sbjct: 130 RNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEE 189 Query: 213 D--NPPVSFVKFSP-NGKYILAATLDNTLKL---------WDYSKG---KCLKTYTGHKN 257 + V P + +++D + + ++ SK +C + N Sbjct: 190 SGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTN 249 Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL-QGHTDVVISTACHPTENII 316 Y + + K++ + D ++ WNLQT++ ++ + + D V+ AC +NI+ Sbjct: 250 LAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS--DNIL 307 Query: 317 ASAALEN--------DKTIKL 329 A ++ D+TI+L Sbjct: 308 CLATSDDTFKTNAAIDQTIEL 328 Score = 56.2 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 34/233 (14%), Positives = 77/233 (33%), Gaps = 29/233 (12%) Query: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK----FEKTISGHK 87 P++ + K+ + L ++S D LI++ + K ++ + Sbjct: 89 SPSFQALTNNEANLGICRICKYGDDK--LIAASWDGLIEVIDPRNYGDGVIAVKNLNSNN 146 Query: 88 LGISDVAWSSD--SNLLVSA---SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN 142 + + ++ D S+ L+ S + ++ G + P+ Sbjct: 147 TKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQ 206 Query: 143 L-IVSGSFDESVRI--WDVK----TGKCLKTLPAHS---------DPVSAVHFNRDGSLI 186 S D V + +D + H PV+++ F+ + Sbjct: 207 EGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFL 266 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239 ++ DG+ W+ + + +K + V + S N + AT D+T K Sbjct: 267 YTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDN--ILCLATSDDTFK 317 >5WLC-LL nrPDB Length = 643 Score = 61.2 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 45/242 (18%), Positives = 83/242 (34%), Gaps = 25/242 (10%) Query: 13 ARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKF----SPNGEWLASSSADKL 68 R P+ AT S V L L V+ +K+ S + + + Sbjct: 27 QRVGVQPTQRATSSGVDTVWNENFLY--LEDSKLKVTCLKWVNLASSDTVAIILGMNNGE 84 Query: 69 IKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127 I ++ + + G+ I D+ N L +D+ K L+ Sbjct: 85 IWLYSVLANEVTYKFTTGNSYEIKDIDL--MGNQLWCIDSSDAFYQFDLLQFKLLQ---- 138 Query: 128 HSNYVFCCNFN-----PQSN---LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179 H C N P + ++ S S+ + D++ K + T P H PVS + Sbjct: 139 HFRINNCVQLNKLTIVPAGDSVAQLLVAS--HSISLIDIEEKKVVMTFPGHVSPVSTLQV 196 Query: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239 + I + D ++D SG L+ + + + + S I T D +L+ Sbjct: 197 ITNEFFISGAEGDRFLNVYDIHSGMTKCVLVAESD--IKELSHSGQADSIAVTTEDGSLE 254 Query: 240 LW 241 ++ Sbjct: 255 IF 256 >5WLC-LH nrPDB Length = 896 Score = 61.2 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 55/142 (38%), Gaps = 5/142 (3%) Query: 6 KKPETEAARAQPTPSSSATQSKPTPVKPNYALK----FTLAGHTKAVSSVKFSPNGEWLA 61 K T+ + S P ++ +L+ +T+ VSS+ G+ LA Sbjct: 213 KDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLA 272 Query: 62 SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC 121 A +I I D + + + H + +++S D + L+S +K + +W + + Sbjct: 273 VGFASGVISIVSLADLQI-RLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQ 331 Query: 122 LKTLKGHSNYVFCCNFNPQSNL 143 + + + C PQ N Sbjct: 332 QFLPRLNGIIIDCQVLGPQGNY 353 Score = 55.4 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 43/106 (40%), Gaps = 2/106 (1%) Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRD 182 ++L ++ YV + + G + I + + ++ L H D V ++ F+ D Sbjct: 250 QSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSFSHD 308 Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 228 GS ++S ++ + +W + + L + + P G Y Sbjct: 309 GSYLLSGGWEKVMSLWQLETNSQ-QFLPRLNGIIIDCQVLGPQGNY 353 Score = 46.5 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 14/87 (16%), Positives = 40/87 (45%), Gaps = 1/87 (1%) Query: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136 +++S + +S +A + L + I ++ + ++ LK H + V + Sbjct: 246 SSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLS 304 Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKC 163 F+ + ++SG +++ + +W ++T Sbjct: 305 FSHDGSYLLSGGWEKVMSLWQLETNSQ 331 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 12/103 (11%), Positives = 36/103 (34%), Gaps = 4/103 (3%) Query: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272 + VS + G+ + + + + + ++ H + + G Sbjct: 255 NTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWH---IDSVLSLSFSHDGS 310 Query: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315 +++SG + ++ +W L+T + + ++ P N Sbjct: 311 YLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNY 353 Score = 39.2 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 41/235 (17%), Positives = 87/235 (37%), Gaps = 42/235 (17%) Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLAS-----------SSAD--KLIKIWGAYDGKF--- 79 ++F L ++ +KF+ +G+W+ + SS D ++K W D + Sbjct: 483 KVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWN 542 Query: 80 --EKTISGHKLGISDVAWSSDSNLL------VSASDDKTLKIWDVSSGKCLKTLK----- 126 K I+ H + + + ++A ++ LK W S + LK Sbjct: 543 LKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLP 602 Query: 127 --GHSNYVFCCNFNPQSNLIVSGSFDE-SVRIWDV----KTGKCLKTLPAHS--DPVSAV 177 H + ++ +LI G D+ + +D ++ + KT+ + + V Sbjct: 603 NFNHFSNSVSLAWSQDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTV 662 Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232 D +LIV++ + GQ + + D P V+ V + + ++ Sbjct: 663 KLINDTNLIVAT--RTTLNAINLLRGQVINSF--DLYPFVNGVYKNGHMDRLITC 713 Score = 32.7 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 30/73 (41%), Gaps = 3/73 (4%) Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321 + + G+ + G ++ I +L ++ L+ H D V+S + + + S Sbjct: 259 VSSMAIDNMGQQLAVGFASGVISIVSL-ADLQIRLLKWHIDSVLSLSFSHDGSYLLSGGW 317 Query: 322 ENDKTIKLWKSDC 334 E + LW+ + Sbjct: 318 EK--VMSLWQLET 328 Score = 29.6 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 33/221 (14%), Positives = 74/221 (33%), Gaps = 39/221 (17%) Query: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 77 S + PN+ H S+ +S +G + DK ++I Sbjct: 587 FDSHESNWCLKKISLPNF-------NHFSNSVSLAWSQDGSLIFHGFDDK-LQILDFDTF 638 Query: 78 KFEKTISGHK--------LGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS 129 K +++ K I V +D+NL+V + TL ++ G+ + + + Sbjct: 639 KKFESLENTKTVSEFTLDSEIQTVKLINDTNLIV--ATRTTLNAINLLRGQVINSFDLY- 695 Query: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189 +V N + +++ D +TG + + V + Sbjct: 696 PFVNGVYKNGHMDRLITC---------DERTGNIALVINQQLTDLDGVP---------TI 737 Query: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230 +Y I+D+ L + +S++ ++ + +I Sbjct: 738 NYKSRIIIFDSDLSTKLGNFT--HHEYISWIGWNYDTDFIF 776 >5WLC-LV nrPDB Length = 707 Score = 58.1 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 95/255 (37%), Gaps = 27/255 (10%) Query: 91 SDVAWSSDSNL-LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 + + S D + + + + ++D ++ H++ +F I+S + Sbjct: 60 NKIKVSRDGQYCMATGTYKPQIHVYDFANLSL--KFDRHTDA-ENVDF-----TILSDDW 111 Query: 150 DESVRIWDVKTGKCLKTLPAH-SDPV----SAVHFNR-DGSLIVSSSYDGLCRIWDTASG 203 +SV + + ++ + H + + ++ +N+ + L V +S + L R+ + G Sbjct: 112 TKSVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRL-NLEKG 170 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH---KNEKY 260 + L D V+ V + + A T N ++ WD + N + Sbjct: 171 RFLNPF-KLDTEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPF 229 Query: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPT---ENII 316 + G G+ + YI++L+T E + K QG+ + EN I Sbjct: 230 QVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKI 289 Query: 317 ASAALENDKTIKLWK 331 + + + K+W Sbjct: 290 VTC---DKRIAKIWD 301 Score = 47.7 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 20/158 (12%), Positives = 58/158 (36%), Gaps = 14/158 (8%) Query: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG------ISDVAWSSD 98 T+ V+ V + LA+ + +++ W + ++ ++ +D Sbjct: 180 TEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRND 239 Query: 99 SNLLVSASDDKTLKIWDVSSGKC-LKTLKGHSNYVFCCNFNPQ---SNLIVSGSFDESV- 153 + + I+D+ + + + +G+ + + N IV+ D+ + Sbjct: 240 GLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTC--DKRIA 297 Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191 +IWD GK ++ D ++ + + +++ Sbjct: 298 KIWDRLDGKAYASMEPSVD-INDIEHVPGTGMFFTANE 334 >2VDU-B nrPDB Length = 450 Score = 56.9 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 33/174 (18%), Positives = 62/174 (35%), Gaps = 25/174 (14%) Query: 54 SPNGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112 S +A + +DK + ++ K + +S N + A DD T+ Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLR------KRFCFSKRPNAISIAEDDTTVI 165 Query: 113 IWD-------------VSSGKCLKTLKGHSNYVFCCNFNPQSN---LIVSGSFDESVRIW 156 I D + + GH + + + S+ I++ DE ++I Sbjct: 166 IADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS 225 Query: 157 DVKTGKCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209 + L H VS++ +D L++S+ D WD +G+ L T Sbjct: 226 HYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 Score = 42.7 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 57/161 (35%), Gaps = 9/161 (5%) Query: 180 NRDGSLIVSSSYDGLCRIWDT-ASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDN 236 + + LI + D ++D + + + L + + + + + ++ A Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 Query: 237 TLKLWDY----SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292 + D + + GH + + G ++I++ D + I + Sbjct: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQCF 231 Query: 293 IVQK-LQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332 IV K L GH V S C ++ SA ++ WK+ Sbjct: 232 IVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKT 271 Score = 33.4 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 14/49 (28%), Positives = 19/49 (38%), Gaps = 1/49 (2%) Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83 + + L GH VSS+ + L S+ D I W GK T Sbjct: 231 FIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTF 278 >4FHN-A nrPDB Length = 394 Score = 56.2 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 44/301 (14%), Positives = 99/301 (32%), Gaps = 47/301 (15%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISDVA---- 94 ++ V S+ +LA D +++ SGH ++D+ Sbjct: 96 NSSPVYSL-------FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADV 148 Query: 95 WSSDSNL----LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSF 149 +S+D+ L + S DD TL IW ++ + S+ F P + N ++ G Sbjct: 149 YSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGER 208 Query: 150 DESVRIWD----VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 + ++RI+D + + +T + + ++ L+ + G+ A+ + Sbjct: 209 NGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLP---LVNTCHSSGIAS--SLANVRW 263 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAAT-----LDNTLKLWDYSKGKCLKTYTGHKNEKY 260 + + + + A D+T+KL L G Sbjct: 264 IGSDGSGILAMCKSGAWLRWN--LFANNDYNEISDSTMKL---GPKNLLPNVQGISLFPS 318 Query: 261 CIFANFSVTGGKWIVSGSEDN----LVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316 + A + + + L+ + + I +L ++ H + + Sbjct: 319 LLGACPHPRYMDYFATAHSQHGLIQLINTYEKDSNSIPIQL---GMPIVDFCWHQDGSHL 375 Query: 317 A 317 A Sbjct: 376 A 376 Score = 30.7 bits (68), Expect = 0.78, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 29/79 (36%), Gaps = 11/79 (13%) Query: 264 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL-----QGHTDVVISTA----CHPTEN 314 N S ++ +DN V + + + I+ + GH + V Sbjct: 95 VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNR 154 Query: 315 II--ASAALENDKTIKLWK 331 + A++ +D T+ +W+ Sbjct: 155 LAEQVIASVGDDCTLIIWR 173 >4AV8-A nrPDB Length = 339 Score = 54.6 bits (130), Expect = 5e-08, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 37/79 (46%), Gaps = 3/79 (3%) Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKL-IKIWGAYDGKFEKTISGH--KLGISDVAWSS 97 + H V V+ + G+ +A+ S D I+++ +G + + I D+ WS Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 98 DSNLLVSASDDKTLKIWDV 116 D + L SD TL +++V Sbjct: 235 DGSKLAVVSDKWTLHVFEV 253 Score = 52.7 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 96/248 (38%), Gaps = 19/248 (7%) Query: 58 EWLASSSADK-LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116 ++A S K L+ IW + + + D+ S + + S + I+ Sbjct: 66 NYIAFVSTKKELLHIWDDVKKQDITRVKL-DAAVKDLFLSRE---FIVVSQGDVISIFKF 121 Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD-ESVRIWDVKTGKCLKT-----LPAH 170 G + + C F L+ S F+ + + ++T + AH Sbjct: 122 --GNPWNKITEDIKFGGVCEF-ANGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAH 178 Query: 171 SDPVSAVHFNRDGSLIVSSSYDGL-CRIWDTASGQCLKTLIDD-DNPPVSFVKFSPNGKY 228 ++PV V NR G ++ + S DG R++ T +G ++ D + +++SP+G Sbjct: 179 ANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSK 238 Query: 229 ILAATLDNTLKLWD-YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS-GSEDNLVYIW 286 + + TL +++ ++ + + + +S+ K VS GS D + W Sbjct: 239 LAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCKIA-W 297 Query: 287 NLQTKEIV 294 T ++ Sbjct: 298 ISDTGLVI 305 Score = 32.7 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 31/213 (14%), Positives = 72/213 (33%), Gaps = 24/213 (11%) Query: 129 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP-VSAVHFNRDGSLIV 187 SN + FN + ++ + + +D+ LK + + P + + I Sbjct: 14 SNPIVDYEFNQDQSCLIVS----TPKSFDIYNVHPLKRIMSQEMPDAGTIRMLHRTNYIA 69 Query: 188 SSSYDG-LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG 246 S L IWD Q + + D VK + + + + + ++ + Sbjct: 70 FVSTKKELLHIWDDVKKQDITRVKLDA-----AVKDLFLSREFIVVSQGDVISIFKFGNP 124 Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG-----HT 301 T V ++ + +++ LQT +G H Sbjct: 125 WNKITEDIKFGGVCEFANGLLVYSNEFNL-----GQIHVTRLQTDAEQVVGKGVLVKAHA 179 Query: 302 DVVISTACHPTENIIASAALENDKT-IKLWKSD 333 + V + +++A+ + D T I+++++D Sbjct: 180 NPVKMVRLNRKGDMVATCS--QDGTLIRVFQTD 210 >5K1H-B nrPDB Length = 576 Score = 52.7 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 57/358 (15%), Positives = 111/358 (31%), Gaps = 85/358 (23%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS-- 106 + V++SP G +LA+ I +WG K + S H+ + + +S LV+ S Sbjct: 169 TYVRWSPKGTYLATFHQRG-IALWGGEKFKQIQRFS-HQG-VQLIDFSPCERYLVTFSPL 225 Query: 107 ----DD-KTLKIWDVSSGKCLKTLK------------GHSN--------------YVFCC 135 DD + + IWD+ +G + H Sbjct: 226 MDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSM 285 Query: 136 NFNPQSNLIVSGSFD-------ESVRIW-----DVKTGKCLKTLPAHSDPV--------- 174 + +L +SG D + W D+ L LP+ + Sbjct: 286 GLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPS-RQEIRVRNLFNVV 344 Query: 175 -SAVHFNRDGSLIVSSSYDGLCR----------IWDTASGQCLKTLIDDDNPPVSFVKFS 223 +H+ ++G + D + I+ Q +++ + + Sbjct: 345 DCKLHWQKNGDYLC-VKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETII-AFAWE 402 Query: 224 PNGKYILA-ATLDNTLKLWDY---SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG-- 277 PNG + + Y S GK + K + IF +S G +++G Sbjct: 403 PNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQANTIF--WSPQGQFVVLAGLR 460 Query: 278 SEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA----ALENDKTIKLWK 331 S + + + T + + PT + ++ + + D LW Sbjct: 461 SMNGALAF--VDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSHKVDNAYWLWT 516 Score = 51.9 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 34/211 (16%), Positives = 72/211 (34%), Gaps = 16/211 (7%) Query: 114 WDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 173 WD+ + K L G+ Y ++ S D + W+ + Sbjct: 110 WDIPEKQPFKDL-GNLRYWLEEAECRDQYSVIFESGDRTSIFWN-DVKDPVSIEERARWT 167 Query: 174 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT 233 + V ++ G+ + + G +W + ++ V + FSP +Y++ + Sbjct: 168 ETYVRWSPKGTYLATFHQRG-IALWGGEKFKQIQRFSHQ---GVQLIDFSPCERYLVTFS 223 Query: 234 ------LDNT-LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 286 D + +WD G + + + + IF GK+ + D + I+ Sbjct: 224 PLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKW--SHDGKFFARMTLD-TLSIY 280 Query: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIA 317 + ++ K + + P NIIA Sbjct: 281 ETPSMGLLDKKSLKISGIKDFSWSPGGNIIA 311 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 84/238 (35%), Gaps = 33/238 (13%) Query: 72 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW----DVSSGKCLKTLKG 127 W + + K + + + + A D ++ S D+T W D S + Sbjct: 110 WDIPEKQPFKDLGNLRYWLEE-AECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTE 168 Query: 128 HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187 ++P+ + + + +W + K ++ V + F+ +V Sbjct: 169 -----TYVRWSPKGTYLAT-FHQRGIALWGGEKFKQIQRFSH--QGVQLIDFSPCERYLV 220 Query: 188 SSS------YD-GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240 + S D IWD +G + + + K+S +GK+ TLD TL + Sbjct: 221 TFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLD-TLSI 279 Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298 ++ L K+ K +FS + G N++ W + K+I ++ Sbjct: 280 YETPSMGLLDK----KSLKISGIKDFSWSPGG--------NIIAFWVPEDKDIPARVT 325 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 42/104 (40%), Gaps = 12/104 (11%) Query: 29 TPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDGKFEKTISG 85 VK N ++ + + +++ +SP G+++ + S + + D I+ Sbjct: 423 YHVKSNGKIELSKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVM-NIAE 481 Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWD--VSSGKCLKTLKG 127 H + SDV W +V++ + W V + L T +G Sbjct: 482 HYMA-SDVEWDPTGRYVVTS-----VSWWSHKVDNAYWLWTFQG 519 >5BPW-A nrPDB Length = 843 Score = 47.3 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 39/91 (42%), Gaps = 5/91 (5%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN---YVFCCNFNPQSNLIVSGSF 149 + WS +L+ A+ + + ++S + + + N V C + P L+ Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALA 85 Query: 150 D-ESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179 D + + + DV+ + L + PVS +H+ Sbjct: 86 DTKKIVLCDVEKPESLHSFSV-EAPVSCMHW 115 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 38/102 (37%), Gaps = 17/102 (16%) Query: 46 KAVSSVKFSPNGEWLASSSADKLI---------KIWGAYDGKFEKTISGHKLGISDVAWS 96 + + + +SP + +A ++ + ++W + ++ +AW Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTG------KEVTCLAWR 74 Query: 97 SDSNLLVSASDD-KTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 D LL A D K + + DV + L + V C ++ Sbjct: 75 PDGKLLAFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHW 115 Score = 41.9 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 38/92 (41%), Gaps = 6/92 (6%) Query: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD---PVSAVHFNRDGSLIVSSSY 191 ++P+ +LI + V + + + + + P + + V+ + + DG L+ + Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALA 85 Query: 192 D-GLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222 D + D + L + + PVS + + Sbjct: 86 DTKKIVLCDVEKPESLHSFSVE--APVSCMHW 115 Score = 38.8 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 42/108 (38%), Gaps = 4/108 (3%) Query: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--PPVSFVKFSPNGKYI 229 + + ++ LI ++ G + AS + + ++N V+ + + P+GK + Sbjct: 21 QEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLL 80 Query: 230 LAATLD-NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 A D + L D K + L +++ + C+ + S Sbjct: 81 AFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHWMEVTVESSVLTS 127 Score = 28.4 bits (62), Expect = 4.7, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 15/44 (34%), Gaps = 6/44 (13%) Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 +W+ E K V A P ++A A + K + Sbjct: 54 RVWSFPPNENTGK------EVTCLAWRPDGKLLAFALADTKKIV 91 >5BPT-A nrPDB Length = 741 Score = 45.4 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 42/91 (46%), Gaps = 5/91 (5%) Query: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN---YVFCCNFNPQSNLIVSGSF 149 +AWS +L+ + + + +++ + + +L + N V C + P ++ G Sbjct: 19 LAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFGLA 78 Query: 150 D-ESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179 D + V + DV+ + L + + P+S + + Sbjct: 79 DTKKVILCDVEKPESLHSFSLET-PISCMQW 108 Score = 43.5 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 14/102 (13%), Positives = 35/102 (34%), Gaps = 17/102 (16%) Query: 46 KAVSSVKFSPNGEWLASSSADKLI---------KIWGAYDGKFEKTISGHKLGISDVAWS 96 + + +SP + +A + + ++W + ++ +AW Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTG------KEVTCLAWR 67 Query: 97 SDSNLLVSASDD-KTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137 D +L D K + + DV + L + + + C + Sbjct: 68 PDGKILAFGLADTKKVILCDVEKPESLHSFSLET-PISCMQW 108 Score = 30.4 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 15/44 (34%), Gaps = 6/44 (13%) Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327 +W+L E K V A P I+A + K I Sbjct: 47 RVWSLPPNENTGK------EVTCLAWRPDGKILAFGLADTKKVI 84 >4YHC-A nrPDB Length = 468 Score = 43.5 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 14/101 (13%), Positives = 31/101 (30%), Gaps = 2/101 (1%) Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVSFVKFSPNGK 227 H + + + + S D +WD L + P + + P G Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 Y+ + D TL + + + ++ H + + Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 Score = 41.1 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 22/96 (22%), Positives = 40/96 (41%), Gaps = 3/96 (3%) Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY--VFCCNFNPQSNL 143 H+L I +A S + S D++L +WD+ L + +PQ N Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179 + S D ++ I +V++ + HS P S ++ Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNV 123 Score = 39.2 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 46/127 (36%), Gaps = 13/127 (10%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNL 101 H + + S N + AS D+ + +W + +S ++ + +A N Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN--FNPQSN--------LIVSGSFDE 151 + S D TL I +V S + HS N + P ++ +V Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHKDDEWKNFELVVVESSG 147 Query: 152 SVRIWDV 158 ++++ + Sbjct: 148 EIQVFSL 154 >1C5K-A nrPDB Length = 439 Score = 42.3 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 86/245 (35%), Gaps = 22/245 (8%) Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASS---SADKLIKIWGAYDGKFEK--TISGHKLGISD 92 +F + + + S +SP+G LA S + I +G + + H Sbjct: 193 QFVVHRSPQPLMSPAWSPDGSKLAYVTFESGRSALVIQTLANGAVRQVASFPRHNG---A 249 Query: 93 VAWSSDSNLLVSA-SDDKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149 A+S D + L A S +L ++ D++SG+ + G SN F NL + Sbjct: 250 PAFSPDGSKLAFALSKTGSLNLYVMDLASGQIRQVTDGRSNNTEPTWFPDSQNLAFTSDQ 309 Query: 150 DESVRIWDVK-TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG---LCRIWDTASG-- 203 +++ V G + + + DG +V S +G D A+G Sbjct: 310 AGRPQVYKVNINGGAPQRITWEGSQNQDADVSSDGKFMVMVSSNGGQQHIAKQDLATGGV 369 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263 Q L + D+ P +PNG ++ ++ + + + F Sbjct: 370 QVLSSTFLDETPS-----LAPNGTMVIYSSSQGMGSVLNLVSTDGRFKARLPATDGQVKF 424 Query: 264 ANFSV 268 +S Sbjct: 425 PAWSP 429 >6FYY-p nrPDB Length = 763 Score = 41.9 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 86/304 (28%), Gaps = 58/304 (19%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS-- 106 + V+FSP G +L S + WG + + H + + + S + LV+ S Sbjct: 234 NYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRFY-HPD-VRNSSVSPNEKYLVTFSTE 290 Query: 107 -----------------DDKTLKIWDVSSGKCLKTLKG-HSNYVFC--CNFNPQSNLIVS 146 + L IWD++SG + T S Y+ ++ Sbjct: 291 PIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPYLKWPLVRWSYNDKYCAR 350 Query: 147 GSFDESVRIWD-VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 D + + D K L+ + F +G Sbjct: 351 MVGDSLI-VHDATKNFMPLEAKALKPSGIRDFSFAPEG--------------------VK 389 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAAT------LDNTLKLWDYSKGKCLKTYTGHKNEK 259 L+ + D P V ++P LK + + + + ++ E Sbjct: 390 LQPFRNGDEPSVLLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSNVTLHWQNQAEF 449 Query: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319 C GK S + + +L+ D V P N + Sbjct: 450 LCFNVERHTKSGKTQFS--NLQICRLTERDIPVEKVELK---DSVFEFGWEPHGNRFVTI 504 Query: 320 ALEN 323 ++ Sbjct: 505 SVHE 508 Score = 36.5 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 27/186 (14%), Positives = 54/186 (29%), Gaps = 27/186 (14%) Query: 67 KLIKIWGAYDGKFEKTISGHKLGISD-VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 K W + + + + + ++ V +S L S + W + L+ Sbjct: 209 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 267 Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESV-------------------RIWDVKTGKCLKT 166 H V + +P +V+ S + + IWD+ +G + T Sbjct: 268 Y-H-PDVRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMAT 325 Query: 167 LPAHSDPVSA---VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 P P V ++ + D L + D + F+ Sbjct: 326 FPVIKSPYLKWPLVRWSYNDKYCARMVGDSLI-VHDATKNFMPLEAKALKPSGIRDFSFA 384 Query: 224 PNGKYI 229 P G + Sbjct: 385 PEGVKL 390 Score = 30.7 bits (68), Expect = 0.79, Method: Composition-based stats. Identities = 17/116 (14%), Positives = 42/116 (36%), Gaps = 6/116 (5%) Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 W++ + + +N ++V+FSP G Y+ + + W L+ + Sbjct: 209 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 267 Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 + K++V+ S + ++ + + +K +GH + A Sbjct: 268 YHPDVRNSSVS-----PNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 318 >5GRS-A nrPDB Length = 396 Score = 41.5 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 14/101 (13%), Positives = 31/101 (30%), Gaps = 2/101 (1%) Query: 169 AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP-PVSFVKFSPNGK 227 H + + + + S D +WD L + P + + P G Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 268 Y+ + D TL + + + ++ H + + Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMP 127 Score = 38.5 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 42/103 (40%), Gaps = 17/103 (16%) Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWD---------VSSGKCLKTLKGHSNYVFCCN 136 H+L I +A S + S D+ L +WD +S + +TLK Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLK-------AIA 81 Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179 +PQ N + S D ++ I +V++ + H P S ++ Sbjct: 82 LDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNV 123 Score = 38.1 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 45/127 (35%), Gaps = 13/127 (10%) Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG--ISDVAWSSDSNL 101 H + + S N + AS D+ + +W + +S ++ + +A N Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN--FNPQSN--------LIVSGSFDE 151 + S D TL I +V S + H N + P ++ +V Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTHKDDEWKNFELVVVESSG 147 Query: 152 SVRIWDV 158 ++++ + Sbjct: 148 EIQVFSL 154 >4U1F-A nrPDB Length = 497 Score = 39.2 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 45/304 (14%), Positives = 85/304 (27%), Gaps = 58/304 (19%) Query: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS-- 106 + V+FSP G +L S + WG + + + + + S + LV+ S Sbjct: 66 NYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRFY--HPDVRNSSVSPNEKYLVTFSTE 122 Query: 107 -----------------DDKTLKIWDVSSGKCLKTLKG-HSNYVFC--CNFNPQSNLIVS 146 + L IWD++SG + T S Y+ ++ Sbjct: 123 PIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPYLKWPLVRWSYNDKYCAR 182 Query: 147 GSFDESVRIWD-VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205 D + + D K L+ + F +G Sbjct: 183 MVGDSLI-VHDATKNFMPLEAKALKPSGIRDFSFAPEG--------------------VK 221 Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAAT------LDNTLKLWDYSKGKCLKTYTGHKNEK 259 L+ + D P V ++P LK + + + + ++ E Sbjct: 222 LQPFRNGDEPSVLLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSNVTLHWQNQAEF 281 Query: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319 C GK S + + +L+ D V P N + Sbjct: 282 LCFNVERHTKSGKTQFS--NLQICRLTERDIPVEKVELK---DSVFEFGWEPHGNRFVTI 336 Query: 320 ALEN 323 ++ Sbjct: 337 SVHE 340 Score = 34.6 bits (78), Expect = 0.056, Method: Composition-based stats. Identities = 27/186 (14%), Positives = 54/186 (29%), Gaps = 27/186 (14%) Query: 67 KLIKIWGAYDGKFEKTISGHKLGISD-VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125 K W + + + + + ++ V +S L S + W + L+ Sbjct: 41 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 99 Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESV-------------------RIWDVKTGKCLKT 166 H V + +P +V+ S + + IWD+ +G + T Sbjct: 100 Y-H-PDVRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMAT 157 Query: 167 LPAHSDPVSA---VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 P P V ++ + D L + D + F+ Sbjct: 158 FPVIKSPYLKWPLVRWSYNDKYCARMVGDSLI-VHDATKNFMPLEAKALKPSGIRDFSFA 216 Query: 224 PNGKYI 229 P G + Sbjct: 217 PEGVKL 222 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 17/116 (14%), Positives = 42/116 (36%), Gaps = 6/116 (5%) Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252 W++ + + +N ++V+FSP G Y+ + + W L+ + Sbjct: 41 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 99 Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308 + K++V+ S + ++ + + +K +GH + A Sbjct: 100 YHPDVRNSSVS-----PNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 150 Score = 29.2 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 2/62 (3%) Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92 PN+ H V + SPN ++L + S + +I F K GH+L I D Sbjct: 91 PNFDRLRRFY-HPD-VRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWD 148 Query: 93 VA 94 +A Sbjct: 149 IA 150 >2EEP-A nrPDB Length = 706 Score = 38.8 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 23/139 (16%), Positives = 60/139 (43%), Gaps = 22/139 (15%) Query: 68 LIKIWGAYDGKFEKTISGH--KLGISDVAWSSDSNLLVS-----ASDDKTLKIWDVSSGK 120 + I+ GK +G + +++++WS D N+L A ++ + +D +G+ Sbjct: 236 TVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGR 295 Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR-----------IWDVKTGKCLKTLPA 169 ++TL ++ + +P + + GS ++ + ++D TG+ ++ + Sbjct: 296 FVRTLFVETDKHYVEPLHPLT--FLPGSNNQFIWQSRRDGWNHLYLYDT-TGRLIRQVTK 352 Query: 170 HSDPVSAVH-FNRDGSLIV 187 V+ F+ G+ + Sbjct: 353 GEWEVTNFAGFDPKGTRLY 371 >4NOX-A nrPDB Length = 746 Score = 38.1 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 54/371 (14%), Positives = 109/371 (29%), Gaps = 98/371 (26%) Query: 48 VSSVKFSPNGEWLASSS-----------------ADKL-IKIWGAYDGKFEKTISGHKL- 88 V+ V FSP ++L + S D IW + ++ + + Sbjct: 240 VNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFAQQDIH 299 Query: 89 ---------------GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF 133 + WS+D + + ++ I+++ L V Sbjct: 300 PEEHGPKKGPPKFPWPV--FKWSADDKYVARLNQGTSISIYELPKMNLLDKQAVKIEGVM 357 Query: 134 CCNFNP----------QSNLIVS-----GSFDESVRIWDVKTGKCLKTLPAHSDPVSAV- 177 + P L G+ V + + + + ++TL S VS V Sbjct: 358 DFEWAPATVQREGVKTYEQLFCFWTPEIGNNPARVGLMSIPSKQIVRTLNLFS--VSDVK 415 Query: 178 -HFNRDGSLIV------SSSYDG---LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227 H+ +G+ + S S I+ ++D V + P G Sbjct: 416 MHWQSEGTYLCVKVDRHSKSKKSQATTLEIFRVKEKGVPVEVVDTIKDTVINFAWEPKGD 475 Query: 228 YILAATLD-----------NTLKLW--DYSKGKCLKTYTGHKN--EKYCIFANFSVTGGK 272 + T ++ + + KG + ++ H EK A + G+ Sbjct: 476 RFVIITTPEPVGATAVPPKTSVSFFCPELKKGNQVGSFK-HLRTLEKKNHNAIYWSPKGR 534 Query: 273 WIVSGSEDNL----VYIWNL----QTKEIVQKLQG---------HTDVVISTACHPTENI 315 ++V + N + W+L + E + L H + P+ Sbjct: 535 FVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQLMGTGDHYG-ITDVEWDPSGRY 593 Query: 316 IASAALENDKT 326 +A+ A T Sbjct: 594 VATWASAWKHT 604 Score = 37.3 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 45/130 (34%), Gaps = 29/130 (22%) Query: 49 SSVKFSPNGEWLASSSADKL----IKIWGAYD----GKFEKTIS--------GHKLGISD 92 +++ +SP G ++ ++ ++ W + EK ++ G GI+D Sbjct: 525 NAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKDLAACLQLMGTGDHYGITD 584 Query: 93 VAWSSDSNLLVSASDDKTLKIWD--VSSGKCLKTLKG------HSNYVFCCNFNPQSNLI 144 V W + + W + +G L KG H + P+ + Sbjct: 585 VEWDPSGRYVAT-----WASAWKHTMENGYHLYDFKGELLREEHIEKFKQWQWRPRPPTL 639 Query: 145 VSGSFDESVR 154 ++ + +R Sbjct: 640 LTKEEQKQIR 649 Score = 33.4 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 52/117 (44%), Gaps = 28/117 (23%) Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS------SYDGLCRIWDTASG-------- 203 V + K L+TL + +A++++ G +V + S D WD Sbjct: 510 VGSFKHLRTLEKKNH--NAIYWSPKGRFVVIATVHNTQSSD--LEFWDLDFDGEKPENEK 565 Query: 204 ---QCLKTLIDDDNPPVSFVKFSPNGKYILA------ATLDNTLKLWDYSKGKCLKT 251 CL+ + D+ ++ V++ P+G+Y+ T++N L+D+ KG+ L+ Sbjct: 566 DLAACLQLMGTGDHYGITDVEWDPSGRYVATWASAWKHTMENGYHLYDF-KGELLRE 621 >4IMM-A nrPDB Length = 399 Score = 38.1 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 42/298 (14%), Positives = 93/298 (31%), Gaps = 66/298 (22%) Query: 50 SVKFSPNGEWLASSS----ADKLIKIWGAYDGKFEKTIS--GHKLGISDVAWSSDSNLLV 103 S+ + N E + + + + G GK + G + ++A SS + L+ Sbjct: 100 SIAWQYNAEDVITGGVGIDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALI 159 Query: 104 SA------SDDKTLKIWDVSSGKCLKTLKGHSN--YVFCCN--FNPQSNLIVSGSFDESV 153 S ++ T+ D++SG + V + ++ G D + Sbjct: 160 SGDKVIVITNSGTIFGLDINSGATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRI 219 Query: 154 RIWDVKTGKCLKT----LPAHSDPVSAVHFNRDGS------LIVSSSYDGLCRIWDTASG 203 D TG + T L S + + + DG+ + ++SY G +D +G Sbjct: 220 HALDTMTGAPVWTRRVGLAMGSGEIDQLR-DIDGTPTVVDHYLYAASYSGQLAGFDMTTG 278 Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL---------KLWD--------YSKG 246 + + ++ + ++ ++ D + KLW+ + Sbjct: 279 RTMFVSELSSTKKLTTLA-----DAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNP 333 Query: 247 KCLKTYTGHKNEKYCIFANFSVTG-----------------GKWIVSGSEDNLVYIWN 287 + TY + + + + S D +V +W Sbjct: 334 VTIGTYIAVGDADGVVHILNHQGQIISRANTKGALTNLTVINNRLYAQSADGVVTVWQ 391 >3WJ9-A nrPDB Length = 412 Score = 37.3 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 57/158 (36%), Gaps = 17/158 (10%) Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225 A S+P ++ +G L ++ + I DT SG L L + + FSP Sbjct: 29 KFEAISEPARNACYSPNGKLFAYATATQVV-INDTESGAKLTQLPAANT---YELGFSPL 84 Query: 226 GKYILA-----ATLDNT----LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276 GKY+ D T +K+W+ G+ + ++ + + + +V+ Sbjct: 85 GKYLSTWERPGKEADGTPKQNMKVWNTETGQLVFSFVQRNQTGWNLQYTCDESLAARLVT 144 Query: 277 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314 N V+ + + + + A P +N Sbjct: 145 ----NEVHFYETGNMSKGPIAKLRVEGISDFALSPGQN 178 Score = 36.1 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 48/127 (37%), Gaps = 17/127 (13%) Query: 87 KLGISDVAWSSDSNL--LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144 + I DV W++DS +V I+D + + ++ + F+P S I Sbjct: 268 EGPIHDVCWNADSKEFGIVYGYMPAKTAIFD--NRANVVSIIPPAPR-NTLIFSPNSRYI 324 Query: 145 VSGSF---DESVRIWDVKTG-KCLKTLPAHSDPVSAVHFNRDGSLIVSSSY------DGL 194 + F S+ I+D K + T+ A + F+ D ++++ D Sbjct: 325 LLAGFGNLQGSIDIFDAANNMKKITTVEAANCTYC--EFSPDSQFLLTAVTSPRLRVDNS 382 Query: 195 CRIWDTA 201 +IW Sbjct: 383 IKIWHIT 389 Score = 31.5 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 19/48 (39%), Gaps = 8/48 (16%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASS------SADKLIKIWGAY 75 N T+ + +FSP+ ++L ++ D IKIW Sbjct: 344 NMKKITTVEA--ANCTYCEFSPDSQFLLTAVTSPRLRVDNSIKIWHIT 389 >5CWW-B nrPDB Length = 595 Score = 37.3 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 40/119 (33%), Gaps = 17/119 (14%) Query: 10 TEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLI 69 T R TP + + + PN L HT + + P+ L D Sbjct: 103 TAGYRIIKTPVAD--DIRQLVMSPNQDFLAVLTSHTVHICIL---PDSSHLHI--QDTTP 155 Query: 70 ---KIWGAYDGKFEKTISGHKLGISDVAWSS---DSNLLVSASDDKTLKIWDVSSGKCL 122 K W + + + W + + LV+ ++D +++W++S+ Sbjct: 156 FKPKFWTLGPTTHVTS----RSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRW 210 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 35/88 (39%), Gaps = 9/88 (10%) Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177 + L L H+ V C S+L + + + W + + + V + Sbjct: 125 NQDFLAVLTSHT--VHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTS----RSAVVSA 178 Query: 178 HFNR---DGSLIVSSSYDGLCRIWDTAS 202 ++ +G +V+ + D + R+W+ ++ Sbjct: 179 VWHPLGVNGHALVTVTEDAIVRVWELST 206 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 32/101 (31%), Gaps = 12/101 (11%) Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN-TLKLWDYSKGKCLKTYT 253 R + Q ++ + P+ ++ K W + Sbjct: 117 IRQLVMSPNQDFLAVLTSHTV---HICILPDSSHLHIQDTTPFKPKFWTLGPTTHV---- 169 Query: 254 GHKNEKYCIFANFSVTG--GKWIVSGSEDNLVYIWNLQTKE 292 + + A + G G +V+ +ED +V +W L T + Sbjct: 170 --TSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTAD 208 >5L8S-A nrPDB Length = 604 Score = 36.1 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 58/164 (35%), Gaps = 22/164 (13%) Query: 171 SDPVSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229 + ++ + D +V +++ +G +W L + +F+KF P +Y+ Sbjct: 15 TYTITNFAVSSDEKRLVFNANLNGKMNLWAMDLPDTYPYLFAHRDESCNFIKFDPENRYV 74 Query: 230 LAA---TLDNTLKLWDYSK--GKCLKTYTGHKNEKY----------CIFANFSVTGGKWI 274 LA D +++ G TG +EKY C++ S ++ Sbjct: 75 LAGFDKDGDENYQIYAIPNEGGLPHPLITGDASEKYYFSHLSADGKCVYYETSKENPSFL 134 Query: 275 VS------GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312 + ED L+ + + T E+ + V A T Sbjct: 135 NTRIRNLETGEDRLLNVGEVSTTELAAVSENEESFVYLRAFANT 178 >5SUM-A nrPDB Length = 468 Score = 35.8 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 30/64 (46%), Gaps = 1/64 (1%) Query: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245 ++++ Y +D +G+ L + DD S +GKY+L LD ++++D Sbjct: 338 VITTDYKKNVFKFDG-NGRMLGKVGRDDITGSSTYIHVHDGKYLLQGGLDRYVRIFDIKT 396 Query: 246 GKCL 249 K L Sbjct: 397 NKML 400 Score = 32.3 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 7/26 (26%), Positives = 14/26 (53%) Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCL 122 D L+ D+ ++I+D+ + K L Sbjct: 375 HDGKYLLQGGLDRYVRIFDIKTNKML 400 >4GNB-A nrPDB Length = 299 Score = 35.8 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 37/194 (19%), Positives = 68/194 (35%), Gaps = 18/194 (9%) Query: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210 + V WD T + + PVS+V + G + + W S L T+ Sbjct: 37 KKVCRWDSFTKQVQRVTM--DAPVSSVALRQSGGYVATIGTKFCALNWKEQSAVVLATVD 94 Query: 211 DD-DNPPVSFVKFSPNGKYILAATLDNTL-KLWDYSKGKCLKTYTGHKNEKY------CI 262 +D N + K P G+Y + T + + +G + H +KY Sbjct: 95 NDKKNNRFNDGKVDPAGRYFAGTMAEETAPAVLERHQGALYSLFPDHHVKKYFDQVDISN 154 Query: 263 FANFSVTGG--KWIVSGSEDNLVYIWNLQTKEI-----VQKLQGHTDVVISTACHPTENI 315 ++S+ +I S S + ++LQT +I V KL+ + + Sbjct: 155 GLDWSLDHKIFYYIDSLSYSVDAFDYDLQTGQISNRRSVYKLEKEEQIPDGMCIDAEGKL 214 Query: 316 IASAALENDKTIKL 329 + + I+L Sbjct: 215 WVAC-YNGGRVIRL 227 >5WLC-LR nrPDB Length = 817 Score = 35.4 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 34/78 (43%), Gaps = 6/78 (7%) Query: 221 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 280 K ++LA TLD+ ++L++ K ++ + E+ I F+ + I +++ Sbjct: 675 KGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIFNEELDQAISILNDE 734 Query: 281 NLVYI------WNLQTKE 292 L+ + WN K Sbjct: 735 QLILLMKRCRDWNTNAKT 752 >5OLJ-A nrPDB Length = 723 Score = 34.2 bits (77), Expect = 0.071, Method: Composition-based stats. Identities = 19/91 (20%), Positives = 34/91 (37%), Gaps = 16/91 (17%) Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKL-IKIWGA-------YDGKFEKTISG 85 L L+ H V FSP+G +A + + IK + DG+ ++G Sbjct: 128 RRNLVKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTTDGQINSVLNG 187 Query: 86 HKLGISD--------VAWSSDSNLLVSASDD 108 + + ++WS+D+ L D Sbjct: 188 ATDWVYEEEFGVTNLMSWSADNAFLAFVRSD 218 Score = 30.0 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 15/102 (14%), Positives = 37/102 (36%), Gaps = 6/102 (5%) Query: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG-LCRIWDTASGQCLKTLIDDDN 214 +DV+ +K L H V F+ DG ++ + + +D + + T ++ Sbjct: 125 YDVRRN-LVKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTTDGQINS 183 Query: 215 PPVSFVKFSPNGKY----ILAATLDNTLKLWDYSKGKCLKTY 252 + ++ +++ + DN + S + Y Sbjct: 184 VLNGATDWVYEEEFGVTNLMSWSADNAFLAFVRSDESAVPEY 225 >4HXF-B nrPDB Length = 622 Score = 34.2 bits (77), Expect = 0.082, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 79/247 (31%), Gaps = 61/247 (24%) Query: 52 KFSPNGEWLAS---SSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA- 105 + SP+G+ +A + K +IW +K + I + W+ DS L++ Sbjct: 65 RISPDGKKIAFMRFNEEKKTAQIWVADLKTLSAKKVLEA--KNIRSIEWNQDSRRLLAVG 122 Query: 106 --------------------------SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139 + T + D + ++ + ++ Sbjct: 123 FKRREDEDFIFEDDVPAWFDNMGFFDGEKTTFWVIDTEGEEVIEQFE--KPRFSSGIWHG 180 Query: 140 QSNLIVSGSFD---ESVRIWDV---KTGKCLKTLPAHSDPVSAVHFNRDGSLIV------ 187 S ++ D + WD+ K G+ K VS + DG I+ Sbjct: 181 DSIVVSVPHRDVIPRYFKYWDIYLWKDGEEEKLFEK----VSFYAIDSDGERILLYGKPE 236 Query: 188 --SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK--LWDY 243 S I+D +K ++DD + V+ K NGK + ++ LWD Sbjct: 237 KKYVSEHDKIYIYDGE----VKGILDDIDREVAQAKI-RNGKVYFTLFEEGSVNLYLWDG 291 Query: 244 SKGKCLK 250 + K Sbjct: 292 EVREIAK 298 >1MG2-A nrPDB Length = 390 Score = 33.8 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 31/73 (42%), Gaps = 8/73 (10%) Query: 150 DESVRIWDVKTGKCLKTLP-AHSDPVSAVHFNRDGS---LIVSSSYDGLCRIWDTASGQC 205 V + D KTG+ L H + +++ ++D +S+ D I D SG+ Sbjct: 314 SRFVVVLDAKTGERLAKFEMGH--EIDSINVSQDEKPLLYALSTG-DKTLYIHDAESGEE 370 Query: 206 LKTLID-DDNPPV 217 L+++ P V Sbjct: 371 LRSVNQLGHGPQV 383 Score = 33.1 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 7/73 (9%) Query: 65 ADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLLVSA--SDDKTLKIWDVSSGKC 121 A + + + A G+ GH+ I + S D L+ A + DKTL I D SG+ Sbjct: 313 ASRFVVVLDAKTGERLAKFEMGHE--IDSINVSQDEKPLLYALSTGDKTLYIHDAESGEE 370 Query: 122 LKTLK--GHSNYV 132 L+++ GH V Sbjct: 371 LRSVNQLGHGPQV 383 >2QT9-A nrPDB Length = 766 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 20/141 (14%), Positives = 46/141 (32%), Gaps = 45/141 (31%) Query: 40 TLAGHTKAVSSVKFSPNGEWLA-------------SSSADKLIKIWGAYDGKFEK--TIS 84 T +++ SP+G+++ ++S D I+ + I Sbjct: 94 TFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYD----IYDLNKRQLITEERIP 149 Query: 85 GHKLGISDVAWSSDSNLLVSA-SDDKTLKI----------WDVSSGKCLKTLKGHSNYVF 133 + ++ WS + L ++D +KI W +GK G +++V+ Sbjct: 150 NNTQWVT---WSPVGHKLAYVWNNDIYVKIEPNLPSYRITW---TGKEDIIYNGITDWVY 203 Query: 134 ---------CCNFNPQSNLIV 145 ++P + Sbjct: 204 EEEVFSAYSALWWSPNGTFLA 224 >6DAM-A nrPDB Length = 617 Score = 31.9 bits (71), Expect = 0.41, Method: Composition-based stats. Identities = 29/175 (16%), Positives = 54/175 (30%), Gaps = 34/175 (19%) Query: 135 CNFNPQSNLI-VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193 +++PQ+ +SG V + D + + T + + G +++ DG Sbjct: 424 VSYSPQTGYFYISG---NHVCM-DYEPFEVEYT-AGQPYVGATLSMFPAGKDVITGKEDG 478 Query: 194 LCRI-----WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248 + WD +G+ + + + V + G + TL+ LK D GK Sbjct: 479 SNNLGQFTAWDATTGKIIWSNKEQF--SVWSGSLATAGGVVFYGTLEGYLKAVDAKTGKE 536 Query: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 303 L + V W + K+ V L G Sbjct: 537 LYRFKTPSGII---------------------GNVNTWEYEGKQYVGVLSGVGGW 570 >1FLG-A nrPDB Length = 582 Score = 31.9 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 35/99 (35%), Gaps = 5/99 (5%) Query: 236 NTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295 +L+ D GK + + H ++A T G + +G+ D ++ ++ + + Sbjct: 466 GSLRAMDPVSGKVVWEHKEHLP----LWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELW 521 Query: 296 KLQGHTDVVI-STACHPTENIIASAALENDKTIKLWKSD 333 K Q + +V + + LW D Sbjct: 522 KFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGD 560 >6IGR-A nrPDB Length = 656 Score = 31.5 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 54/339 (15%), Positives = 101/339 (29%), Gaps = 51/339 (15%) Query: 2 ATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLA 61 + KP+ + AR + S T G + ++SP+G+ LA Sbjct: 42 EEDPAKPDKDFARPR---YRSGLWLSEGGAARPLTHAETGRGDSAP----RWSPDGQNLA 94 Query: 62 ---SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDVS 117 S+ K + G + ++ K G+S WS D + + + D K Sbjct: 95 FVRSAGEVKAALMLLPLKGGEARRVTHFKNGVSGPQWSPDGRFIAFTTTADTEDK---RD 151 Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177 + L ++ P+ ++ ++DV+ K L+ A + A+ Sbjct: 152 ERGEARVLTRPVYRANGADWLPERP--------AALWLYDVEADK-LREWYAPEIGIGAL 202 Query: 178 HFNRD--GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF---------SPNG 226 + D G LIV S + W D P + + P+G Sbjct: 203 SWWPDSRGVLIVQSEDEWQASQWRQDVYDLPLPTADAPAAPQKLLDWNSAAHGLAPHPDG 262 Query: 227 KYILAATL------DNTLKLWDYSKGKCLKTYTGHKNEK-----YCIFANFSVTGGKWIV 275 + L+ G+ + TGH + G +W+ Sbjct: 263 QRFALIGRPAGKGNTEHAHLYLIENGQHRRLDTGHDHPVGDAVGGDCHVGAFPEGPRWL- 321 Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGH-TDVVISTACHPTE 313 D +++ + V H V + P Sbjct: 322 ----DGDTLLFSSTVRGSVGLFTAHIGGGVKAYDHDPQG 356 >3MWP-A nrPDB Length = 577 Score = 31.5 bits (70), Expect = 0.56, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 28/92 (30%), Gaps = 14/92 (15%) Query: 141 SNLIVSGSFDESVRIWDVKTGKCLK--------------TLPAHSDPVSAVHFNRDGSLI 186 N D VR+WDVK + L T D AV D LI Sbjct: 157 GNQGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDAVQALTDLGLI 216 Query: 187 VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218 ++ Y + + +ID ++ Sbjct: 217 YTAKYPNTSDLDRLTQSHPILNMIDTKKSSLN 248 >1SUS-A nrPDB Length = 247 Score = 30.7 bits (68), Expect = 0.85, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 42/113 (37%), Gaps = 14/113 (12%) Query: 1 MATEEKKPETEAARAQPTPSSSATQSK----PTPVKPNYALKFTLAGHTKAVSSVKFSPN 56 MAT E + +TE+ R Q S QS + + + V+ P Sbjct: 1 MATNEDQKQTESGRHQEVGHKSLLQSDALYQYILETSVFPREHEAMKELREVT--AKHPW 58 Query: 57 GEWLASSSAD------KLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103 + ++SAD L+K+ A + +G+ L + +A D +L Sbjct: 59 N--IMTTSADEGQFLSMLLKLINAKNTMEIGVYTGYSLLATALAIPEDGKILA 109 >3R3L-A nrPDB Length = 582 Score = 30.7 bits (68), Expect = 0.94, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 26/86 (30%), Gaps = 14/86 (16%) Query: 147 GSFDESVRIWDVKTGKCLK--------------TLPAHSDPVSAVHFNRDGSLIVSSSYD 192 D VR+WDVK + L T D V D LI ++ Y Sbjct: 155 AGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQVDLNDVVQALTDLGLIYTAKYP 214 Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVS 218 + + +ID ++ Sbjct: 215 NTSDLDRLTQSHPILNMIDTKKSSLN 240 >1Z68-A nrPDB Length = 719 Score = 30.7 bits (68), Expect = 0.96, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 56/155 (36%), Gaps = 33/155 (21%) Query: 106 SDDKTLKIWDVSSGKCLKTLKGHS-NYVFCCNF--NPQSNLI-VSGSFDESVR------- 154 S D + ++++ +G+ L + V N+ +P + + + + R Sbjct: 33 SADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSKLWRYSYTATY 92 Query: 155 -IWDVKTGKCLK--TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI-----------WDT 200 I+D+ G+ ++ LP P+ + ++ GS + + + ++ Sbjct: 93 YIYDLSNGEFVRGNELPR---PIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITFNG 149 Query: 201 ASGQCLK-----TLIDDDNPPVSFVKFSPNGKYIL 230 + ++ + +SPNGK++ Sbjct: 150 RENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLA 184 >1BEV-1 nrPDB Length = 281 Score = 30.7 bits (68), Expect = 0.97, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 30/84 (35%), Gaps = 4/84 (4%) Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302 + T+ H+ F S+ G + +G+ + W + +E VQ L+ Sbjct: 55 IETRTIVPTHGIHETSVESFFGRSSLVGMPLLATGTS---ITHWRIDFREFVQ-LRAKMS 110 Query: 303 VVISTACHPTENIIASAALENDKT 326 IIA+++ + T Sbjct: 111 WFTYMRFDVEFTIIATSSTGQNVT 134 >5HAX-A nrPDB Length = 742 Score = 30.7 bits (68), Expect = 0.98, Method: Composition-based stats. Identities = 8/52 (15%), Positives = 18/52 (34%) Query: 189 SSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240 +S D +WD ++ ++ V P + T+ + L + Sbjct: 86 ASIDSSLFLWDYTHPNPELIGYEEATHTITAVALVPPKPGVFVKTITHVLVV 137 >5LJ5-t nrPDB Length = 503 Score = 30.0 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 10/68 (14%), Positives = 26/68 (38%), Gaps = 3/68 (4%) Query: 53 FSPNGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWSSDSNLLVSASDDKT 110 + LA S D ++ ++ + + I +V ++ + +V D+T Sbjct: 338 LHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVEC-DQT 396 Query: 111 LKIWDVSS 118 + +D+ Sbjct: 397 VVCFDLRK 404 >6FTI-5 nrPDB Length = 705 Score = 30.0 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 11/73 (15%), Positives = 26/73 (35%), Gaps = 2/73 (2%) Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60 + +++ + P + S V + + +T H+ V+S +S L Sbjct: 433 LDISRPDKKSKKQQDSTYPIKNEVASGMILVMAFFLITYTF--HSTWVTSEAYSSPSIVL 490 Query: 61 ASSSADKLIKIWG 73 ++ D I+ Sbjct: 491 SARGGDGSRIIFD 503 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 30/77 (38%), Gaps = 2/77 (2%) Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223 L T HS V++ ++ ++ + DG I+D + L + + + Sbjct: 468 LITYTFHSTWVTSEAYSSPSIVLSARGGDGSRIIFD-DFREAYYWLRHNTPEDAKVMSW- 525 Query: 224 PNGKYILAATLDNTLKL 240 + Y + A + T+ + Sbjct: 526 WDYGYQITAMANRTILV 542 >4MF9-A nrPDB Length = 360 Score = 30.0 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 34/271 (12%), Positives = 78/271 (28%), Gaps = 49/271 (18%) Query: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKI----WDVS----------SGKCL 122 + E + K +V S++ + + S D L++ W+ + + + Sbjct: 83 TRNEHCVHERKGPYREVTVSANGQMGLVVSPDIDLRLFLGGWNAVFAIAEETARGTQRSI 142 Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-----VKTGKCLKTLPAHSDPVSAV 177 + V + S VR W+ ++ + L H A Sbjct: 143 QVFDQQGVAVHKV-------FLAEASD---VRAWEPLVERLRAAEQDAVLALHEPRAPAA 192 Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI-------- 229 D + ++ +G + DT L + + + Sbjct: 193 AL-VDAQIDAAALREGWAALKDTHHFHALLKKHGAQRTQALRLAGGEWAERLDNGDLAKL 251 Query: 230 --LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287 AA + ++ C++ +TG + F+V ++ + + +W Sbjct: 252 FEAAAESGLPIMVF-VGNAHCIQIHTGPVCNLKWLDDWFNVLDPEFNLHLKTTGIAELWR 310 Query: 288 LQTKEIVQKLQGHTDVVIS-TACHPTENIIA 317 ++ +V S A P +I Sbjct: 311 VRKPST-------DGIVTSWEAFDPDGELIV 334 >4ZB4-A nrPDB Length = 360 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 10/68 (14%), Positives = 26/68 (38%), Gaps = 3/68 (4%) Query: 53 FSPNGEWLASSSADKLIKIWGAYDGKFEKT--ISGHKLGISDVAWSSDSNLLVSASDDKT 110 + LA S D ++ ++ + + I +V ++ + +V D+T Sbjct: 195 LHKDSLLLALYSPDGILDVYNLSSPDQASSRFPVDEEAKIKEVKFADNGYWMVVEC-DQT 253 Query: 111 LKIWDVSS 118 + +D+ Sbjct: 254 VVCFDLRK 261 >4IQB-A nrPDB Length = 315 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 21/63 (33%), Gaps = 6/63 (9%) Query: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN------LVYIW 286 T T+ ++ CL+ T ++ + W +SGS D V IW Sbjct: 52 TGTGTISIFGMQSKYCLRNGTIPLLTTKRVYWKGVLEELLWFISGSTDGKLLMEKNVKIW 111 Query: 287 NLQ 289 Sbjct: 112 EKN 114 >1K3I-A nrPDB Length = 656 Score = 29.2 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 12/67 (17%), Positives = 29/67 (43%), Gaps = 5/67 (7%) Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD-GLCRIWD 199 + ++ S+D S I +T T+ H + + +G ++V+ D ++D Sbjct: 216 GGITLTSSWDPSTGIVSDRT----VTVTKHDMFCPGISMDGNGQIVVTGGNDAKKTSLYD 271 Query: 200 TASGQCL 206 ++S + Sbjct: 272 SSSDSWI 278 >3ZKJ-A nrPDB Length = 261 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 10/71 (14%) Query: 247 KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED--NLVYIW--------NLQTKEIVQK 296 C+K H + + A++ VSGS D NL+ +L + Sbjct: 50 SCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAA 109 Query: 297 LQGHTDVVIST 307 +GH + V S Sbjct: 110 RRGHVECVNSL 120 >2PFZ-A nrPDB Length = 301 Score = 28.8 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 27/66 (40%), Gaps = 4/66 (6%) Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220 G+ L T A+ DPV + DG +++ YD +++ K L + V Sbjct: 62 GEILLTNFANEDPVYEL----DGLPFLATGYDASFKLYQAQKPFLEKKLASQGMMLLYSV 117 Query: 221 KFSPNG 226 + P G Sbjct: 118 AWPPQG 123 >6IGB-A nrPDB Length = 364 Score = 28.0 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 54/169 (31%), Gaps = 34/169 (20%) Query: 189 SSYDGL-CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN----------- 236 S +G+ +D A G L S++ F+P+ + + + Sbjct: 14 GSSEGIQVYRFDGADGSVKGPLRVAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRA 73 Query: 237 TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE---DNLVYIWNLQ---- 289 T +D G+ + + +++ S G V+ + V + ++ Sbjct: 74 TSYRFDPISGRLQQISQVQTLADHPTYSSLSHDGRYLFVANYSVQPEGSVAVLPVRADGS 133 Query: 290 ------------TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKT 326 +K +++ GH V+S P + + L DK Sbjct: 134 LAPVVQVESHQASKVHPRQVSGHVHSVVS---SPDGQYLFAPDLGADKV 179 >4QI7-A nrPDB Length = 806 Score = 27.7 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 43/133 (32%), Gaps = 16/133 (12%) Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH----- 255 S Q +T ++ + P Y+++A + KLW + K + GH Sbjct: 395 DSEQKNRTFSHTSYMYINGERGGPLATYLVSAKKRSNFKLWLNTAVKRVIREGGHITGVE 454 Query: 256 ----KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311 +N Y + T G+ ++S I +++ G D + Sbjct: 455 VEAFRNGGYSGIIPVTNTTGRVVLSAGTFGSAKI-------LLRSGIGPKDQLEVVKASA 507 Query: 312 TENIIASAALEND 324 + S + D Sbjct: 508 DGPTMVSNSSWID 520 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.139 0.385 Lambda K H 0.267 0.0425 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,139,890 Number of Sequences: 36641 Number of extensions: 500848 Number of successful extensions: 7443 Number of sequences better than 10.0: 184 Number of HSP's better than 10.0 without gapping: 271 Number of HSP's successfully gapped in prelim test: 66 Number of HSP's that attempted gapping in prelim test: 1203 Number of HSP's gapped (non-prelim): 1461 length of query: 334 length of database: 10,336,785 effective HSP length: 98 effective length of query: 236 effective length of database: 6,745,967 effective search space: 1592048212 effective search space used: 1592048212 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 59 (27.3 bits)