BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P56523 (687 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5IKK-A nrPDB 1383 0.0 5EDU-B nrPDB 302 3e-82 5TD7-A nrPDB 282 3e-76 1C3R-A nrPDB 105 7e-23 4ZUN-A nrPDB 104 1e-22 6G3O-A nrPDB 101 1e-21 4BKX-B nrPDB 100 2e-21 5ICN-B nrPDB 100 3e-21 5D1C-A nrPDB 99 7e-21 3MEN-A nrPDB 98 1e-20 4A69-A nrPDB 94 2e-19 3EXA-A nrPDB 30 5.0 4ZU2-A nrPDB 29 7.7 >5IKK-A nrPDB Length = 657 Score = 1383 bits (3579), Expect = 0.0, Method: Compositional matrix adjust. Identities = 657/657 (100%), Positives = 657/657 (100%) Query: 31 TNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEA 90 TNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEA Sbjct: 1 TNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEA 60 Query: 91 IKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS 150 IKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS Sbjct: 61 IKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS 120 Query: 151 DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNV 210 DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNV Sbjct: 121 DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNV 180 Query: 211 SVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNY 270 SVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNY Sbjct: 181 SVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNY 240 Query: 271 GCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAA 330 GCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAA Sbjct: 241 GCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAA 300 Query: 331 GDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR 390 GDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR Sbjct: 301 GDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR 360 Query: 391 LHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFED 450 LHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFED Sbjct: 361 LHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFED 420 Query: 451 WKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSL 510 WKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSL Sbjct: 421 WKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSL 480 Query: 511 LVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISK 570 LVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISK Sbjct: 481 LVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISK 540 Query: 571 NIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLV 630 NIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLV Sbjct: 541 NIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLV 600 Query: 631 FVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ 687 FVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ Sbjct: 601 FVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ 657 >5EDU-B nrPDB Length = 745 Score = 302 bits (774), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 166/365 (45%), Positives = 220/365 (60%), Gaps = 10/365 (2%) Query: 56 KSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREA 115 ++GL YD M H L + HPE P+R+LR+ +++ G L + R A Sbjct: 390 RTGLVYDQNMMNHCNLWD-SHHPEVPQRILRIMCRLEELGLAGRC-------LTLTPRPA 441 Query: 116 TLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCT 175 T ELL HS E + TEKM +L DS+Y + CA+LA G+A Sbjct: 442 TEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVE 501 Query: 176 AVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDI 235 AV++G+V N AVVRPPGHHAE GFC FN+V+V AR Q R+LIVDWD+ Sbjct: 502 AVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHA-QTISGHALRILIVDWDV 560 Query: 236 HHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGM 295 HHGNGTQ F DDP+VLYVSLHRY++G F+P + G + G G G TVN+ W+ M Sbjct: 561 HHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRM 620 Query: 296 GDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLA 355 GD DY+ A+ R+V+P+AYEF+P+LV+VS GFDAA GD +G ++P YAH+T +LMGLA Sbjct: 621 GDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLA 680 Query: 356 DGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLHTTYACPQ-AVATINHVTKIQSQY 414 G++ + LEGGYNL SIS S A +SLLG PP L A+A+I ++ +Y Sbjct: 681 SGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRY 740 Query: 415 WRCMR 419 WR +R Sbjct: 741 WRSLR 745 >5TD7-A nrPDB Length = 678 Score = 282 bits (722), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 149/382 (39%), Positives = 218/382 (57%), Gaps = 16/382 (4%) Query: 57 SGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREA 115 S L +D M R+ ++ E P R+ +EA++ G + +P R+A Sbjct: 7 SALIFDEEMSRYKLLWTDPACEIEVPERLTVSYEALRTHGLAQRCKA-------VPVRQA 59 Query: 116 TLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCT 175 T +E+L HS+E + V T M+ E+L K + +Y++ CA+LA G+ ++ Sbjct: 60 TEQEILLAHSEEYLEAVKQTPGMNVEELMAFSKKYNDVYFHQNIYHCAKLAAGATLQLVD 119 Query: 176 AVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDI 235 +V+ +V+N A+VRPPGHH++ GFC+FNNV+ A + + + R+LIVDWD+ Sbjct: 120 SVMKREVRNGMALVRPPGHHSQRSAANGFCVFNNVAFAALYAKKNY--NLNRILIVDWDV 177 Query: 236 HHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGM 295 HHG G Q F +DP+VLY S HRYE+ F+P + G+G G G +N+PW+ GM Sbjct: 178 HHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSSVGKGKGSGFNINLPWNKVGM 237 Query: 296 GDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLA 355 + DY+ AF V++PVAYEFDP+LVIVS GFD+A GD G+ P +AH+T +LM LA Sbjct: 238 TNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCALPEIFAHLTHLLMPLA 297 Query: 356 DGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLH-TTYACPQAVATINHVTKIQSQY 414 GK+ + LEGG+NL S+ S SLLG P R+ AC A+ +I +V +QS Y Sbjct: 298 AGKMCVVLEGGFNLTSLGQSVCQTVHSLLGDPTPRISGLGTACDSALESIQNVRNVQSSY 357 Query: 415 WRCMRPKHF---DANPKDAHVD 433 W KH + NPK +D Sbjct: 358 WSSF--KHLAQSETNPKRPRLD 377 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 44/82 (53%), Gaps = 8/82 (9%) Query: 300 YIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKV 359 ++ A +++PVAYEF+P LV+ AA + + HMT ++ GLA G++ Sbjct: 563 FMQALLGLILPVAYEFNPALVLGIVEETAAKTRLM-------RVWGHMTCLIQGLARGRM 615 Query: 360 FISLEG-GYNLDSISTSALAVA 380 L+G +L ++ SAL+ A Sbjct: 616 LTLLQGYDKDLLELTVSALSGA 637 >1C3R-A nrPDB Length = 375 Score = 105 bits (262), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 72/240 (30%), Positives = 115/240 (47%), Gaps = 16/240 (6%) Query: 110 IPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYN--NESAFC-ARLA 166 I +R AT EELL H+++ + + E+ EK + Y N + + F + LA Sbjct: 47 IKSRPATKEELLLFHTEDYINTLMEAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLA 106 Query: 167 CGSAIETCTAVVTGQVKNAFAVVRPPG--HHAEPHKPGGFCLFNNVSVTARSMLQRFPDK 224 GS ++ + G V P G HHA + GFC NN +V + ++ Sbjct: 107 TGSTVQAIEEFLKGNV-----AFNPAGGMHHAFKSRANGFCYINNPAVGIEYLRKK---G 158 Query: 225 IKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGR 284 KR+L +D D HH +G Q AFYD V +SLH+ F G E GEG G G Sbjct: 159 FKRILYIDLDAHHCDGVQEAFYDTDQVFVLSLHQSPEYAF--PFEKGFLEEIGEGKGKGY 216 Query: 285 TVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAY 344 +NIP G+ D ++++A ++ + V F+P++ ++ G D D++ +F L+ A+ Sbjct: 217 NLNIPLP-KGLNDNEFLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAF 275 >4ZUN-A nrPDB Length = 341 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 102/338 (30%), Positives = 144/338 (42%), Gaps = 56/338 (16%) Query: 79 EDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKM 138 E P R + A+K+AG+ V PAR LE +L+VH + + Sbjct: 28 EAPFRAEWILAAVKEAGFDDVV---------APARHG-LETVLKVHDAGYLNFLETAWDR 77 Query: 139 SHEDLANLEKISDSL------------------YYNN--ESAF------CARLACGSAIE 172 E I+ S YY N E+A A + SAI+ Sbjct: 78 WKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAID 137 Query: 173 TCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVD 232 + G K AF++ RPPGHHA GG+C NN +V A+ +L + K++ I+D Sbjct: 138 GADLIAAGH-KAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDK---GAKKIAILD 193 Query: 233 WDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSC 292 D HHGNGTQ FY+ +V + SLH + +P G AE G+G G G T N P Sbjct: 194 VDFHHGNGTQDIFYERGDVFFASLHG-DPAEAFP-HFLGYAEETGKGAGAGTTANYP--- 248 Query: 293 AGMGDGDYIYAFQRVV---MPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQ 349 MG G + + + F + ++VS G D D I F LT Y M + Sbjct: 249 --MGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGR 306 Query: 350 MLMGLADG-KVFISLEGGYNLDSISTSALAVAQSLLGI 386 + A G + + +EGGY + I L VA L G+ Sbjct: 307 TIA--ASGVPLLVVMEGGYGVPEIG---LNVANVLKGV 339 >6G3O-A nrPDB Length = 370 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 74/243 (30%), Positives = 119/243 (48%), Gaps = 17/243 (6%) Query: 114 EATLEELLQVHSQEM--YDRVTNTEKMSH--EDLANLEKISDSLYYNNESAFCARLACGS 169 +AT EE+ + HS E + R + MS + + D ++ FC +L+ G Sbjct: 53 KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFC-QLSTGG 111 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 ++ AV + + AV G HHA+ + GFC N++ + +L+ +RV Sbjct: 112 SV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRV 165 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G + AFY V+ VS H+Y G ++PGT G + G G G VN Sbjct: 166 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNF 221 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y F+ ++ V + P V++ CG D+ +GD +G F LT +A Sbjct: 222 PMR-DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCV 280 Query: 349 QML 351 +++ Sbjct: 281 EVV 283 >4BKX-B nrPDB Length = 482 Score = 100 bits (250), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 131/275 (47%), Gaps = 21/275 (7%) Query: 114 EATLEELLQVHSQEM--YDRVTNTEKMSH--EDLANLEKISDSLYYNNESAFCARLACGS 169 +A EE+ + HS + + R + MS + + D ++ FC +L+ G Sbjct: 58 KANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFC-QLSTGG 116 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 ++ +AV + + AV G HHA+ + GFC N++ + +L+ +RV Sbjct: 117 SV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRV 170 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G + AFY V+ VS H+Y G ++PGT G + G G G VN Sbjct: 171 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNY 226 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y F+ V+ V F P V++ CG D+ +GD +G F LT +A Sbjct: 227 PLR-DGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCV 285 Query: 349 QMLMGLADGKVFISLEGGYNLDSIS---TSALAVA 380 + + + + GGY + +++ T AVA Sbjct: 286 EFVKSFNLPMLMLG-GGGYTIRNVARCWTYETAVA 319 >5ICN-B nrPDB Length = 376 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 131/275 (47%), Gaps = 21/275 (7%) Query: 114 EATLEELLQVHSQEM--YDRVTNTEKMSH--EDLANLEKISDSLYYNNESAFCARLACGS 169 +A EE+ + HS + + R + MS + + D ++ FC +L+ G Sbjct: 58 KANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFC-QLSTGG 116 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 ++ +AV + + AV G HHA+ + GFC N++ + +L+ +RV Sbjct: 117 SV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRV 170 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G + AFY V+ VS H+Y G ++PGT G + G G G VN Sbjct: 171 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNY 226 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y F+ V+ V F P V++ CG D+ +GD +G F LT +A Sbjct: 227 PLR-DGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCV 285 Query: 349 QMLMGLADGKVFISLEGGYNLDSIS---TSALAVA 380 + + + + GGY + +++ T AVA Sbjct: 286 EFVKSFNLPMLMLG-GGGYTIRNVARCWTYETAVA 319 >5D1C-A nrPDB Length = 389 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 89/327 (27%), Positives = 142/327 (43%), Gaps = 43/327 (13%) Query: 102 SPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLA---------NLEKIS-- 150 S D +IP R + + L++ ++ R+ + S E++A +L+K+S Sbjct: 26 SMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQE 85 Query: 151 ------DSLYYN-------NESAFCARLACGSA-IETCTAVVTGQVKNAFAVVRPPG-HH 195 DS+ Y E F A G A I ++ G K A+ G HH Sbjct: 86 GDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK--VAINWSGGWHH 143 Query: 196 AEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVS 255 A+ + GFC N+ + + R K +R+L VD D+HHG+G + AF V+ VS Sbjct: 144 AKKDEASGFCYLNDAVLG----ILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVS 199 Query: 256 LHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEF 315 LH++ G F+PGT G + G G G +VN+P G+ D Y + V+ V F Sbjct: 200 LHKFSPG-FFPGT--GDVSDVGLGKGRYYSVNVPIQ-GGIQDEKYYQICESVLKEVYQAF 255 Query: 316 DPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTS 375 +P V++ G D AGD + F +TP + ++ + + GG+NL + + Sbjct: 256 NPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGFNLANTARC 314 Query: 376 ALAVAQSLLG------IPPGRLHTTYA 396 + +LG IP T Y Sbjct: 315 WTYLTGVILGKTLSSEIPDHEFFTAYG 341 >3MEN-A nrPDB Length = 362 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 68/194 (35%), Positives = 101/194 (52%), Gaps = 13/194 (6%) Query: 185 AFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMA 244 A+A+ RPPGHHA GGFC NN ++ A+++ R RV ++D D+HHG G Q Sbjct: 168 AYALCRPPGHHARVDAAGGFCYLNNAAIAAQALRARH----ARVAVLDTDMHHGQGIQEI 223 Query: 245 FYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAF 304 FY +VLYVS+H + FYP G + G G GLG VN+P G + + F Sbjct: 224 FYARRDVLYVSIHG-DPTNFYPAVA-GFDDERGAGEGLGYNVNLPMP---HGSSEAAF-F 277 Query: 305 QRV--VMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFIS 362 +RV + F PD +++S GFD D Q +T + + ++ L V + Sbjct: 278 ERVDDALRELRRFAPDALVLSLGFDVYRDDPQSQVAVTTDGFGRLGHLIGALRLPTVIVQ 337 Query: 363 LEGGYNLDSISTSA 376 EGGY+++S+ +A Sbjct: 338 -EGGYHIESLEANA 350 >4A69-A nrPDB Length = 376 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 93/373 (24%), Positives = 159/373 (42%), Gaps = 40/373 (10%) Query: 55 KKSGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAR 113 K YDP + FH HP P R+ + G + + Sbjct: 3 KTVAYFYDPDVGNFHYGAG----HPMKPHRLALTHSLVLHYGLYKKM-------IVFKPY 51 Query: 114 EATLEELLQVHSQEMYD---RVTNTEKMSHEDLANLEKISDSL-YYNNESAFCARLACGS 169 +A+ ++ + HS++ D RV+ T N + D + FC+R G+ Sbjct: 52 QASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYT-GA 110 Query: 170 AIETCTAVVTGQVKNAF---AVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKI 225 +++ T Q+ N A+ G HHA+ + GFC N++ + +L+ P Sbjct: 111 SLQGAT-----QLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHP--- 162 Query: 226 KRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRT 285 RVL +D DIHHG+G Q AFY V+ VS H+Y N F+PGT G G G Sbjct: 163 -RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGN-YFFPGT--GDMYEVGAESGRYYC 218 Query: 286 VNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYA 345 +N+P G+ D Y + FQ V+ V + P +++ CG D+ D +G F L+ + Sbjct: 219 LNVPLR-DGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG 277 Query: 346 HMTQMLMGLADGKVFISLEGGYNLDSIS-----TSALAVAQSLLGIPPGRLHTTYACPQA 400 + + + + + GGY + +++ ++L V +++ P + Y P Sbjct: 278 ECVEYVKSF-NIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDF 336 Query: 401 VATINHVTKIQSQ 413 + T+I++Q Sbjct: 337 TLHPDVSTRIENQ 349 >3EXA-A nrPDB Length = 322 Score = 29.6 bits (65), Expect = 5.0, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 27/92 (29%) Query: 67 FHATLSEVDD------HPEDPRRVLRVFEAIKKAG--------YVSNVPSPSDVFL---- 108 H LS++D HP + RRV+R E IK G + PSP ++ + Sbjct: 139 LHDKLSKIDPKAAAAIHPNNYRRVIRALEIIKLTGKTVTEQARHEEETPSPYNLVMIGLT 198 Query: 109 --------RIPAR-EATLEELLQVHSQEMYDR 131 RI R + +EE L ++++YDR Sbjct: 199 MERDVLYDRINRRVDQMVEEGLIDEAKKLYDR 230 >4ZU2-A nrPDB Length = 272 Score = 28.9 bits (63), Expect = 7.7, Method: Compositional matrix adjust. Identities = 15/39 (38%), Positives = 23/39 (58%), Gaps = 3/39 (7%) Query: 349 QMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIP 387 Q+L+ L +G V L GG+ L +S A+A A + G+P Sbjct: 103 QLLVALVEGAV---LGGGFGLACVSDVAIAAADAQFGLP 138 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5IKK-A nrPDB 1155 0.0 5TD7-A nrPDB 470 e-132 5EDU-B nrPDB 444 e-125 4A69-A nrPDB 381 e-106 5ICN-B nrPDB 359 3e-99 4BKX-B nrPDB 359 3e-99 6G3O-A nrPDB 339 2e-93 5D1C-A nrPDB 305 5e-83 4ZUN-A nrPDB 277 1e-74 1C3R-A nrPDB 258 8e-69 3MEN-A nrPDB 207 1e-53 Sequences not found previously or not previously below threshold: 3MJ4-A nrPDB 31 1.4 4V61-AD nrPDB 29 5.6 4WMA-A nrPDB 29 5.7 6BN7-A nrPDB 29 5.8 3CIN-A nrPDB 29 7.2 CONVERGED! >5IKK-A nrPDB Length = 657 Score = 1155 bits (2987), Expect = 0.0, Method: Composition-based stats. Identities = 657/657 (100%), Positives = 657/657 (100%) Query: 31 TNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEA 90 TNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEA Sbjct: 1 TNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEA 60 Query: 91 IKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS 150 IKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS Sbjct: 61 IKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKIS 120 Query: 151 DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNV 210 DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNV Sbjct: 121 DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNV 180 Query: 211 SVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNY 270 SVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNY Sbjct: 181 SVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNY 240 Query: 271 GCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAA 330 GCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAA Sbjct: 241 GCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAA 300 Query: 331 GDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR 390 GDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR Sbjct: 301 GDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR 360 Query: 391 LHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFED 450 LHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFED Sbjct: 361 LHTTYACPQAVATINHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDVIRTYQAKKLFED 420 Query: 451 WKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSL 510 WKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSL Sbjct: 421 WKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRVLGNGTSETNVLNLNDSL 480 Query: 511 LVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISK 570 LVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISK Sbjct: 481 LVDPVSLYVEWAMQQDWGLIDINIPEVVTDGENAPVDILSEVKELCLYVWDNYVELSISK 540 Query: 571 NIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLV 630 NIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLV Sbjct: 541 NIFFIGGGKAVHGLVNLASSRNVSDRVKCMVNFLGTEPLVGLKTASEEDLPTWYYRHSLV 600 Query: 631 FVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ 687 FVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ Sbjct: 601 FVSSSNECWKKAKRAKRRYGRLMQSEHTETSDMMEQHYRAVTQYLLHLLQKARPTSQ 657 >5TD7-A nrPDB Length = 678 Score = 470 bits (1208), Expect = e-132, Method: Composition-based stats. Identities = 149/382 (39%), Positives = 218/382 (57%), Gaps = 16/382 (4%) Query: 57 SGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREA 115 S L +D M R+ ++ E P R+ +EA++ G + +P R+A Sbjct: 7 SALIFDEEMSRYKLLWTDPACEIEVPERLTVSYEALRTHGLAQRCKA-------VPVRQA 59 Query: 116 TLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCT 175 T +E+L HS+E + V T M+ E+L K + +Y++ CA+LA G+ ++ Sbjct: 60 TEQEILLAHSEEYLEAVKQTPGMNVEELMAFSKKYNDVYFHQNIYHCAKLAAGATLQLVD 119 Query: 176 AVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDI 235 +V+ +V+N A+VRPPGHH++ GFC+FNNV+ A + + + R+LIVDWD+ Sbjct: 120 SVMKREVRNGMALVRPPGHHSQRSAANGFCVFNNVAFAALYAKKNY--NLNRILIVDWDV 177 Query: 236 HHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGM 295 HHG G Q F +DP+VLY S HRYE+ F+P + G+G G G +N+PW+ GM Sbjct: 178 HHGQGIQYCFEEDPSVLYFSWHRYEHQSFWPNLPESDYSSVGKGKGSGFNINLPWNKVGM 237 Query: 296 GDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLA 355 + DY+ AF V++PVAYEFDP+LVIVS GFD+A GD G+ P +AH+T +LM LA Sbjct: 238 TNSDYLAAFFHVLLPVAYEFDPELVIVSAGFDSAIGDPEGEMCALPEIFAHLTHLLMPLA 297 Query: 356 DGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLH-TTYACPQAVATINHVTKIQSQY 414 GK+ + LEGG+NL S+ S SLLG P R+ AC A+ +I +V +QS Y Sbjct: 298 AGKMCVVLEGGFNLTSLGQSVCQTVHSLLGDPTPRISGLGTACDSALESIQNVRNVQSSY 357 Query: 415 WRCMRPKHF---DANPKDAHVD 433 W KH + NPK +D Sbjct: 358 WSSF--KHLAQSETNPKRPRLD 377 Score = 36.7 bits (83), Expect = 0.037, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 55/120 (45%), Gaps = 11/120 (9%) Query: 300 YIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKV 359 ++ A +++PVAYEF+P +++ + AA + + HMT ++ GLA G++ Sbjct: 563 FMQALLGLILPVAYEFNP-ALVLGIVEETAAKTRL------MRVWGHMTCLIQGLARGRM 615 Query: 360 FISLEGGYNLDSISTSALAVAQSLLGIPPGRLHTTYACPQAVATINHVTKIQSQYWRCMR 419 L+ GY+ D + + A++ + + P+ V + + + W +R Sbjct: 616 LTLLQ-GYDKDLLELTVSALSGASISPLGP---LRAPKPEDVEMMEKQRQRLQERWGLLR 671 >5EDU-B nrPDB Length = 745 Score = 444 bits (1142), Expect = e-125, Method: Composition-based stats. Identities = 166/365 (45%), Positives = 220/365 (60%), Gaps = 10/365 (2%) Query: 56 KSGLCYDPRMRFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREA 115 ++GL YD M H L + HPE P+R+LR+ +++ G L + R A Sbjct: 390 RTGLVYDQNMMNHCNLWD-SHHPEVPQRILRIMCRLEELGLAGRC-------LTLTPRPA 441 Query: 116 TLEELLQVHSQEMYDRVTNTEKMSHEDLANLEKISDSLYYNNESAFCARLACGSAIETCT 175 T ELL HS E + TEKM +L DS+Y + CA+LA G+A Sbjct: 442 TEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVE 501 Query: 176 AVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDI 235 AV++G+V N AVVRPPGHHAE GFC FN+V+V AR Q R+LIVDWD+ Sbjct: 502 AVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHA-QTISGHALRILIVDWDV 560 Query: 236 HHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGM 295 HHGNGTQ F DDP+VLYVSLHRY++G F+P + G + G G G TVN+ W+ M Sbjct: 561 HHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRM 620 Query: 296 GDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLA 355 GD DY+ A+ R+V+P+AYEF+P+LV+VS GFDAA GD +G ++P YAH+T +LMGLA Sbjct: 621 GDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLA 680 Query: 356 DGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGRLHTTYACPQ-AVATINHVTKIQSQY 414 G++ + LEGGYNL SIS S A +SLLG PP L A+A+I ++ +Y Sbjct: 681 SGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRY 740 Query: 415 WRCMR 419 WR +R Sbjct: 741 WRSLR 745 >4A69-A nrPDB Length = 376 Score = 381 bits (977), Expect = e-106, Method: Composition-based stats. Identities = 90/370 (24%), Positives = 153/370 (41%), Gaps = 34/370 (9%) Query: 55 KKSGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAR 113 K YDP + FH HP P R+ + G + + Sbjct: 3 KTVAYFYDPDVGNFHYGAG----HPMKPHRLALTHSLVLHYGLYKKM-------IVFKPY 51 Query: 114 EATLEELLQVHSQEMYD---RVTNTEKMSHEDLAN-LEKISDSLYYNNESAFCARLACGS 169 +A+ ++ + HS++ D RV+ T N D + FC+R G+ Sbjct: 52 QASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRY-TGA 110 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 +++ T + A+ G HHA+ + GFC N++ + +L+ P RV Sbjct: 111 SLQGATQL--NNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHP----RV 164 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G Q AFY V+ VS H+Y N F+PGT G G G +N+ Sbjct: 165 LYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNY-FFPGT--GDMYEVGAESGRYYCLNV 221 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y + FQ V+ V + P +++ CG D+ D +G F L+ + Sbjct: 222 PLR-DGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECV 280 Query: 349 QMLMGLADGKVFISLEGGYNLDSISTSALA-----VAQSLLGIPPGRLHTTYACPQAVAT 403 + + + + + GGY + +++ V +++ P + Y P Sbjct: 281 EYVKSF-NIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLH 339 Query: 404 INHVTKIQSQ 413 + T+I++Q Sbjct: 340 PDVSTRIENQ 349 >5ICN-B nrPDB Length = 376 Score = 359 bits (920), Expect = 3e-99, Method: Composition-based stats. Identities = 94/391 (24%), Positives = 159/391 (40%), Gaps = 38/391 (9%) Query: 55 KKSGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAR 113 +K YD + ++ HP P R+ + G + Sbjct: 9 RKVCYYYDGDVGNYYYGQG----HPMKPHRIRMTHNLLLNYGLYRKME-------IYRPH 57 Query: 114 EATLEELLQVHSQEM--YDRVTNTEKMSH--EDLANLEKISDSLYYNNESAFCARLACGS 169 +A EE+ + HS + + R + MS + + D ++ FC +L+ G Sbjct: 58 KANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFC-QLSTGG 116 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 ++ +AV + + AV G HHA+ + GFC N++ + +L+ +RV Sbjct: 117 SV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRV 170 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G + AFY V+ VS H+Y G ++PGT G + G G G VN Sbjct: 171 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNY 226 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y F+ V+ V F P V++ CG D+ +GD +G F LT +A Sbjct: 227 PLR-DGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCV 285 Query: 349 QMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLL-----GIPPGRLHTTYACPQAVAT 403 + + + + GGY + +++ L P + Y P Sbjct: 286 EFVKSFNLPMLMLG-GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLH 344 Query: 404 I---NHVTKIQSQYWRCMRPKHFDANPKDAH 431 I N + ++Y ++ + F+ H Sbjct: 345 ISPSNMTNQNTNEYLEKIKQRLFENLRMLPH 375 >4BKX-B nrPDB Length = 482 Score = 359 bits (920), Expect = 3e-99, Method: Composition-based stats. Identities = 94/391 (24%), Positives = 159/391 (40%), Gaps = 38/391 (9%) Query: 55 KKSGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAR 113 +K YD + ++ HP P R+ + G + Sbjct: 9 RKVCYYYDGDVGNYYYGQG----HPMKPHRIRMTHNLLLNYGLYRKME-------IYRPH 57 Query: 114 EATLEELLQVHSQEM--YDRVTNTEKMSH--EDLANLEKISDSLYYNNESAFCARLACGS 169 +A EE+ + HS + + R + MS + + D ++ FC +L+ G Sbjct: 58 KANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFC-QLSTGG 116 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 ++ +AV + + AV G HHA+ + GFC N++ + +L+ +RV Sbjct: 117 SV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRV 170 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G + AFY V+ VS H+Y G ++PGT G + G G G VN Sbjct: 171 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNY 226 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y F+ V+ V F P V++ CG D+ +GD +G F LT +A Sbjct: 227 PLR-DGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCV 285 Query: 349 QMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLL-----GIPPGRLHTTYACPQAVAT 403 + + + + GGY + +++ L P + Y P Sbjct: 286 EFVKSFNLPMLMLG-GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLH 344 Query: 404 I---NHVTKIQSQYWRCMRPKHFDANPKDAH 431 I N + ++Y ++ + F+ H Sbjct: 345 ISPSNMTNQNTNEYLEKIKQRLFENLRMLPH 375 >6G3O-A nrPDB Length = 370 Score = 339 bits (869), Expect = 2e-93, Method: Composition-based stats. Identities = 94/391 (24%), Positives = 158/391 (40%), Gaps = 38/391 (9%) Query: 55 KKSGLCYDPRM-RFHATLSEVDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAR 113 KK YD + ++ HP P R+ + G + Sbjct: 4 KKVCYYYDGDIGNYYYGQG----HPMKPHRIRMTHNLLLNYGLYRKME-------IYRPH 52 Query: 114 EATLEELLQVHSQEM--YDRVTNTEKMSH--EDLANLEKISDSLYYNNESAFCARLACGS 169 +AT EE+ + HS E + R + MS + + D ++ FC +L+ G Sbjct: 53 KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFC-QLSTGG 111 Query: 170 AIETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRV 228 ++ AV + + AV G HHA+ + GFC N++ + +L+ +RV Sbjct: 112 SV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH----QRV 165 Query: 229 LIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNI 288 L +D DIHHG+G + AFY V+ VS H+Y G ++PGT G + G G G VN Sbjct: 166 LYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGT--GDLRDIGAGKGKYYAVNF 221 Query: 289 PWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMT 348 P G+ D Y F+ ++ V + P V++ CG D+ +GD +G F LT +A Sbjct: 222 PMR-DGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCV 280 Query: 349 QMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLL-----GIPPGRLHTTYACPQAVAT 403 +++ + + GY + +++ L P + Y P Sbjct: 281 EVVKTFNLPLLMLGGG-GYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLH 339 Query: 404 I---NHVTKIQSQYWRCMRPKHFDANPKDAH 431 I N + +Y ++ + F+ H Sbjct: 340 ISPSNMTNQNTPEYMEKIKQRLFENLRMLPH 370 >5D1C-A nrPDB Length = 389 Score = 305 bits (781), Expect = 5e-83, Method: Composition-based stats. Identities = 93/365 (25%), Positives = 151/365 (41%), Gaps = 46/365 (12%) Query: 77 HPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTE 136 PE+P + Y S D +IP R + + L++ ++ R+ + Sbjct: 3 EPEEP--ADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK 60 Query: 137 KMSHEDL---------ANLEKIS--------DSLYYN-------NESAFCARLACGSA-I 171 S E++ +L+K+S DS+ Y E F A G A I Sbjct: 61 VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI 120 Query: 172 ETCTAVVTGQVKNAFAVVRPPG-HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLI 230 ++ G K A+ G HHA+ + GFC N+ + + ++ +R+L Sbjct: 121 TAAQCLIDGMCK--VAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRK----FERILY 174 Query: 231 VDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPW 290 VD D+HHG+G + AF V+ VSLH++ G F+PGT G + G G G +VN+P Sbjct: 175 VDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGT--GDVSDVGLGKGRYYSVNVPI 231 Query: 291 SCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQM 350 G+ D Y + V+ V F+P V++ G D AGD + F +TP + Sbjct: 232 QG-GIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKY 290 Query: 351 LMGLADGKVFISLEGGYNLDSISTSALAVAQSLLG------IPPGRLHTTYACPQAVATI 404 ++ + + GG+NL + + + +LG IP T Y P V I Sbjct: 291 ILQWQLATLILG-GGGFNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYG-PDYVLEI 348 Query: 405 NHVTK 409 + Sbjct: 349 TPSCR 353 >4ZUN-A nrPDB Length = 341 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 98/337 (29%), Positives = 141/337 (41%), Gaps = 54/337 (16%) Query: 79 EDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTNTEKM 138 E P R + A+K+AG+ V PAR LE +L+VH + + Sbjct: 28 EAPFRAEWILAAVKEAGFDDVV---------APARHG-LETVLKVHDAGYLNFLETAWDR 77 Query: 139 SHEDLANLEKISDSL------------------YYNNESAFC--------ARLACGSAIE 172 E I+ S YY N + A + SAI+ Sbjct: 78 WKAAGYKGEAIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSMASAID 137 Query: 173 TCTAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVD 232 + G K AF++ RPPGHHA GG+C NN +V A+ +L + K++ I+D Sbjct: 138 GADLIAAGH-KAAFSLCRPPGHHAGIDMFGGYCFINNAAVAAQRLLDK---GAKKIAILD 193 Query: 233 WDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSC 292 D HHGNGTQ FY+ +V + SLH + +P G AE G+G G G T N P Sbjct: 194 VDFHHGNGTQDIFYERGDVFFASLHG-DPAEAFP-HFLGYAEETGKGAGAGTTANYP--- 248 Query: 293 AGMGDGDYIYAFQRVV---MPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQ 349 MG G + + + F + ++VS G D D I F LT Y M + Sbjct: 249 --MGRGTPYSVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGR 306 Query: 350 MLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGI 386 + + + + +EGGY + I L VA L G+ Sbjct: 307 TIAA-SGVPLLVVMEGGYGVPEIG---LNVANVLKGV 339 >1C3R-A nrPDB Length = 375 Score = 258 bits (658), Expect = 8e-69, Method: Composition-based stats. Identities = 77/283 (27%), Positives = 125/283 (44%), Gaps = 23/283 (8%) Query: 74 VDDHPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVT 133 +HP RV + + + D I +R AT EELL H+++ + + Sbjct: 18 PKNHPLKIPRVSLLLR-------FKDAMNLIDEKELIKSRPATKEELLLFHTEDYINTLM 70 Query: 134 NTEKMSHEDLANLEKISDSLYYNN--ESAFC-ARLACGSAIETCTAVVTGQVKNAFAVVR 190 E+ EK + Y N + F + LA GS ++ + G V Sbjct: 71 EAERSQSVPKGAREKYNIGGYENPVSYAMFTGSSLATGSTVQAIEEFLKGNV-----AFN 125 Query: 191 PPG--HHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDD 248 P G HHA + GFC NN +V + ++ KR+L +D D HH +G Q AFYD Sbjct: 126 PAGGMHHAFKSRANGFCYINNPAVGIEYLRKK---GFKRILYIDLDAHHCDGVQEAFYDT 182 Query: 249 PNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVV 308 V +SLH+ F G E GEG G G +NIP G+ D ++++A ++ + Sbjct: 183 DQVFVLSLHQSPEYAF--PFEKGFLEEIGEGKGKGYNLNIPLPK-GLNDNEFLFALEKSL 239 Query: 309 MPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQML 351 V F+P++ ++ G D D++ +F L+ A+ ++ Sbjct: 240 EIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIV 282 >3MEN-A nrPDB Length = 362 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 89/324 (27%), Positives = 132/324 (40%), Gaps = 48/324 (14%) Query: 79 EDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRVTN---- 134 E P R R+ A G+ P D F P + VH + Sbjct: 49 EVPERAARLVAAAFAMGFPVREP---DDFGIAP--------IAAVHDTHYLRFLETVHRE 97 Query: 135 ----TEKMSHEDLANLEKISDSLYYNNESAFCARLACGS----------------AIETC 174 E E ++N+ + + LA GS + Sbjct: 98 WKAMPEDWGDEAMSNIFVREPNALRGVLAQAARHLADGSCPVGEHTWRAAYWSAQSALAA 157 Query: 175 TAVVTGQVKNAFAVVRPPGHHAEPHKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWD 234 A V A+A+ RPPGHHA GGFC NN ++ A+++ R RV ++D D Sbjct: 158 AAAVRDGAPAAYALCRPPGHHARVDAAGGFCYLNNAAIAAQALRARH----ARVAVLDTD 213 Query: 235 IHHGNGTQMAFYDDPNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGLGRTVNIPWSCAG 294 +HHG G Q FY +VLYVS+H + FYP G + G G GLG VN+P Sbjct: 214 MHHGQGIQEIFYARRDVLYVSIHG-DPTNFYPAVA-GFDDERGAGEGLGYNVNLPMP--- 268 Query: 295 MGDGDYIYAFQRV--VMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLM 352 G + + F+RV + F PD +++S GFD D Q +T + + ++ Sbjct: 269 HGSSEAAF-FERVDDALRELRRFAPDALVLSLGFDVYRDDPQSQVAVTTDGFGRLGHLIG 327 Query: 353 GLADGKVFISLEGGYNLDSISTSA 376 L V + EGGY+++S+ +A Sbjct: 328 ALRLPTVIVQ-EGGYHIESLEANA 350 >3MJ4-A nrPDB Length = 397 Score = 31.3 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 20/69 (28%), Positives = 25/69 (36%), Gaps = 5/69 (7%) Query: 197 EPHKPGGFCL-FNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVS 255 E + GF + +R +RVLIVD H G YDD VL Sbjct: 23 EQQESKGFDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAYDC-YDDAGVL--- 78 Query: 256 LHRYENGRF 264 +H Y F Sbjct: 79 IHPYGPHIF 87 >4V61-AD nrPDB Length = 201 Score = 29.3 bits (64), Expect = 5.6, Method: Composition-based stats. Identities = 14/44 (31%), Positives = 24/44 (54%), Gaps = 2/44 (4%) Query: 30 LTNNKPMSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATLSE 73 LTN +P +GS+ L N+S + + L ++RFH ++E Sbjct: 21 LTNKRPRAGSD--LRNQSRSGKRSQYRIRLEEKQKLRFHYGITE 62 >4WMA-A nrPDB Length = 306 Score = 29.3 bits (64), Expect = 5.7, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 28/78 (35%), Gaps = 13/78 (16%) Query: 199 HKPGGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHR 258 G +++ + +M Q P +I R++ +D D+ + + F + N Sbjct: 106 SAGSGTYYSDSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDN-------- 157 Query: 259 YENGRFYPGTNYGCAENC 276 F PG G A Sbjct: 158 -----FLPGAVIGIAREM 170 >6BN7-A nrPDB Length = 864 Score = 29.3 bits (64), Expect = 5.8, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 59/175 (33%), Gaps = 17/175 (9%) Query: 324 CGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSL 383 C D+AA + L H+ + + G + + G + + + + Sbjct: 701 CQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGM 760 Query: 384 LGIPPGRLHTTYACPQAVAT-----INHVTKIQSQYWRCMRPKHFDANPKDAHVDRLHDV 438 +G+ + Y + I V KI+ +WR + P +D Sbjct: 761 IGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTER-KTEPATGFID----- 814 Query: 439 IRTYQAKKLFEDWKITNMPILRDSVSNVFNNQVLCSSNFFQKDNLLVIVHESPRV 493 L E + + P +++ V+N+ + D+L+ +V E R+ Sbjct: 815 ------GDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRI 863 >3CIN-A nrPDB Length = 394 Score = 29.0 bits (63), Expect = 7.2, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 24/55 (43%) Query: 275 NCGEGPGLGRTVNIPWSCAGMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDAA 329 +G LG N+P G+ D + ++ E DPD+++ +C +A Sbjct: 94 EIRKGVHLGSVRNLPIEAEGLEDSMTLKEAVDTLVKEWTELDPDVIVNTCTTEAF 148 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.126 0.347 Lambda K H 0.267 0.0391 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,045,846 Number of Sequences: 36641 Number of extensions: 1050106 Number of successful extensions: 2687 Number of sequences better than 10.0: 16 Number of HSP's better than 10.0 without gapping: 24 Number of HSP's successfully gapped in prelim test: 7 Number of HSP's that attempted gapping in prelim test: 2568 Number of HSP's gapped (non-prelim): 34 length of query: 687 length of database: 10,336,785 effective HSP length: 104 effective length of query: 583 effective length of database: 6,526,121 effective search space: 3804728543 effective search space used: 3804728543 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 62 (28.6 bits)