BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P56206 (506 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1ATI-A nrPDB 994 0.0 1B76-A nrPDB 674 0.0 5Z5E-A nrPDB 250 1e-66 2PME-A nrPDB 202 2e-52 5C52-B nrPDB 113 2e-25 3IKM-B nrPDB 112 3e-25 5C53-B nrPDB 103 1e-22 3IKL-A nrPDB 103 2e-22 1G5I-A nrPDB 102 4e-22 1H4S-A nrPDB 40 0.002 4RQF-A nrPDB 39 0.004 1NJ2-A nrPDB 34 0.13 5UCM-A nrPDB 31 1.3 1NJ8-A nrPDB 31 1.3 2ZR2-A nrPDB 30 3.3 2ZTG-A nrPDB 30 3.5 3WQY-A nrPDB 29 4.0 3JS4-A nrPDB 28 7.2 >1ATI-A nrPDB Length = 505 Score = 994 bits (2570), Expect = 0.0, Method: Compositional matrix adjust. Identities = 488/504 (96%), Positives = 489/504 (97%) Query: 3 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 62 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME Sbjct: 2 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 61 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE 122 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE Sbjct: 62 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE 121 Query: 123 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEAS 182 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMF+ GP Sbjct: 122 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFQDLRGPRGGRGL 181 Query: 183 LAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIE 242 LAYLRPETAQGIFVNFKNVLDATSRKL FGIAQIGKAFRNEITPRNFIFRVREFEQMEIE Sbjct: 182 LAYLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEITPRNFIFRVREFEQMEIE 241 Query: 243 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPHG 302 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPE AHYAKATVDILYRFPHG Sbjct: 242 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPESSAHYAKATVDILYRFPHG 301 Query: 303 LEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS 362 ELEGIA RTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS Sbjct: 302 SLELEGIAQRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS 361 Query: 363 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLK 422 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLK Sbjct: 362 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLK 421 Query: 423 ARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRD 482 ARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRD Sbjct: 422 ARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRD 481 Query: 483 RDTMEQIRLHVDELEGFLRERLRW 506 RDTMEQIRLHVDELEGFLRERLRW Sbjct: 482 RDTMEQIRLHVDELEGFLRERLRW 505 >1B76-A nrPDB Length = 442 Score = 674 bits (1738), Expect = 0.0, Method: Compositional matrix adjust. Identities = 331/347 (95%), Positives = 332/347 (95%) Query: 160 WTPPRYFNMMFKTYVGPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKA 219 WTPPRYFNMMF+ GP LAYLRPETAQGIFVNFKNVLDATSRKL FGIAQIGKA Sbjct: 96 WTPPRYFNMMFQDLRGPRGGRGLLAYLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKA 155 Query: 220 FRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ 279 FRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ Sbjct: 156 FRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ 215 Query: 280 QPPEELAHYAKATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHS 339 QPPE AHYAKATVDILYRFPHG ELEGIA RTDFDLGSHTKDQEALGITARVLRNEHS Sbjct: 216 QPPESSAHYAKATVDILYRFPHGSLELEGIAQRTDFDLGSHTKDQEALGITARVLRNEHS 275 Query: 340 TQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAP 399 TQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAP Sbjct: 276 TQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAP 335 Query: 400 IKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTV 459 IKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTV Sbjct: 336 IKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTV 395 Query: 460 DYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERLRW 506 DYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERLRW Sbjct: 396 DYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERLRW 442 Score = 191 bits (485), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 92/96 (95%), Positives = 92/96 (95%), Gaps = 2/96 (2%) Query: 3 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 62 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME Sbjct: 2 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 61 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRY 98 GLDASVLTHRLVLHYSGHEATFADPMVDN K RY Sbjct: 62 GLDASVLTHRLVLHYSGHEATFADPMVDN--AKARY 95 >5Z5E-A nrPDB Length = 534 Score = 250 bits (638), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 179/548 (32%), Positives = 271/548 (49%), Gaps = 120/548 (21%) Query: 16 RGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDMEGLDASVLTHRLVL 75 +GF + +SEIY + G YDYG LG LKNN W + + +D +++ + V Sbjct: 31 KGFFYPASEIYNSIAGFYDYGYLGTLLKNNFINEWKNYFLRLHPNFWEVDPAIVMPKEVF 90 Query: 76 HYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEENLHALVQAMMQ 135 SGH F DP+V+ + R+R DHL++E+ + ++ E L ++ + Sbjct: 91 IASGHLENFNDPIVECK-NGHRFRADHLIEEK-----------LNIKAEGL-----SLSE 133 Query: 136 APERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEA-------------- 181 E V P P ++FN+MF Y+GP EA Sbjct: 134 MEE------LLKNVRCPICNAP--LGKVKWFNLMFPIYIGPDSQEALNLLKNLKENVSEQ 185 Query: 182 --------------SLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPR 227 + AYLRPETAQG +V FK +KLP G+A +GKAFRNEI+PR Sbjct: 186 YIKDIIERVKKMVENEAYLRPETAQGPYVMFKREFILHRQKLPLGLAVVGKAFRNEISPR 245 Query: 228 NFIFRVREFEQMEIEYFVRPGEDEY-------------------------------WHRY 256 + R+REF Q E++ F P ++E+ ++ Y Sbjct: 246 QLLLRLREFTQAELQIFFDPEDNEFDINEVKDVELNFLDKEGNYKRIKVKDLPFPEFYAY 305 Query: 257 WVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFP-HGLEELEGIANRTDF 315 +V + ++++ +G+ E L + +E A Y K VDI FP +G +E+ GI RTD Sbjct: 306 FVGKVKQFYERLGIPEERLRFRELSEKEKAFYNKYHVDIEINFPTYGWKEVGGIHYRTDH 365 Query: 316 DLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAE 375 DL H K ++ + L + Q+ K F+P+V+E S GVDR VLAL+ Sbjct: 366 DLSGHMK------VSGKDL----TVQK-------DNKKFIPHVLELSFGVDRNVLALIDL 408 Query: 376 AFTREEL-------PNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLAL 428 T EE E+R+VLK+ LAPIKVAV PL+K +PE+ E AK + +L Sbjct: 409 FLTEEEYEIERDNQKVKEKRVVLKIPKHLAPIKVAVFPLLK-KPELIEKAKEV-YNMLKN 466 Query: 429 GLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQ 488 ++Y++ G+IG+ YRR DE+G P+A+T+DY T+ +TVT+RDRDTM+Q Sbjct: 467 YFYPIIYDEQGSIGRRYRRVDEIGVPYAITIDYQTLED---------NTVTIRDRDTMKQ 517 Query: 489 IRLHVDEL 496 +R+ +++L Sbjct: 518 VRVKIEDL 525 >2PME-A nrPDB Length = 693 Score = 202 bits (515), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 165/588 (28%), Positives = 256/588 (43%), Gaps = 107/588 (18%) Query: 14 KRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDMEGLDASVLTHRL 73 KRR F Q+ IYGG+ G+YD+GP+G LKNN+ Q W + + E +E +D ++LT Sbjct: 75 KRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILE-IDCTMLTPEP 133 Query: 74 VLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEENLHALVQAM 133 VL SGH FAD MV + + +R DHLLK ++++ ++E + E L Q Sbjct: 134 VLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLD 193 Query: 134 MQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASLAYLRPETAQG 193 + V P +G D +PP FN+MFKT++GP + YLRPETAQG Sbjct: 194 NYGQQELADLFVNYNVKSPITG--NDLSPPVSFNLMFKTFIGPGGNMP--GYLRPETAQG 249 Query: 194 IFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIEYFVRPGEDEY- 252 IF+NFK +L+ KLPF AQIG +FRNEI+PR+ + RVREF EIE+FV P E ++ Sbjct: 250 IFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHP 309 Query: 253 -------WHRYWVEERLK----------------------------------WWQEMGLS 271 H Y + + + ++G+S Sbjct: 310 KFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKVGIS 369 Query: 272 RENLVPYQQPPEELAHYAKATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITA 331 + L Q E+AHYA D + +G E+ G A+R+ +DL H + + + Sbjct: 370 PDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPLVAE 429 Query: 332 RVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVL 391 + L+ E T + +P G Y + A + LA+ E + E E+ Sbjct: 430 KPLK-EPKTVNVVQFEPSKGAIGKAY--KKDAKLVMEYLAICDECYITEMEMLLNEKGEF 486 Query: 392 KLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLL--ALGLGRVLY---EDT-----GNI 441 ++ + ++ + R + T Y + + ++ + GLGR++Y E T G+ Sbjct: 487 TIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDE 546 Query: 442 GKAYRRHDEVGTPFAVTV-----------------------------------------D 460 + + V PF +V Sbjct: 547 QRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYAR 606 Query: 461 YDTIGQS------KDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRE 502 D IG + D + T T+RDRD+M QIR + EL +++ Sbjct: 607 TDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQD 654 >5C52-B nrPDB Length = 485 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 126/506 (24%), Positives = 203/506 (40%), Gaps = 113/506 (22%) Query: 9 LVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDMEGL 64 L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + + Sbjct: 69 LLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPV 128 Query: 65 DASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEE 124 DA LH+ P++ D + E L+ + + E+ +E Sbjct: 129 DA--------LHHK------PGPLLPG---------DSAFRLVSAETLREILQDKELSKE 165 Query: 125 NLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASLA 184 L A ++ +++ SG+ Sbjct: 166 QLVAFLENVLKT-----------------SGK---------------------------- 180 Query: 185 YLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIFRVREFEQMEI 241 LR G ++ N LD +++LP+G+AQIG F + RN + + E + + Sbjct: 181 -LRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASL 239 Query: 242 EYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPH 301 +F P W +W+ RL+WW++ +S N EE + + Y FP Sbjct: 240 VWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRKGNKLYYNFPW 295 Query: 302 GLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEP 361 G E +E T ++LG H G + +L RD K VP V+ Sbjct: 296 GKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR--KNVVPCVLSV 338 Query: 362 SAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEY 417 + +DRG+LA L ++F E R VLKL P LAPIKVA+ E+ + Sbjct: 339 NGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQV 398 Query: 418 AKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRL 474 + L LL G+ L ++ + Y ++DE+ F V V T+ ++G L Sbjct: 399 CQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL---ENGLIHL 455 Query: 475 KDTVTVRDRDTMEQIRLHVDELEGFL 500 R RDT + +H+ +L+ FL Sbjct: 456 ------RSRDTTMKEMMHISKLKDFL 475 >3IKM-B nrPDB Length = 427 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 126/508 (24%), Positives = 204/508 (40%), Gaps = 113/508 (22%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 9 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 68 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE 122 +DA LH+ P++ D + E L+ + + E+ Sbjct: 69 PVDA--------LHHK------PGPLLPG---------DSAFRLVSAETLREILQDKELS 105 Query: 123 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEAS 182 +E L A ++ +++ SG+ Sbjct: 106 KEQLVAFLENVLKT-----------------SGK-------------------------- 122 Query: 183 LAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIFRVREFEQM 239 LR G ++ N LD +++LP+G+AQIG F + RN + + E + Sbjct: 123 ---LRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEA 179 Query: 240 EIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRF 299 + +F P W +W+ RL+WW++ +S N EE + + Y F Sbjct: 180 SLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRKGNKLYYNF 235 Query: 300 PHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVI 359 P G E +E T ++LG H G + +L RD K VP V+ Sbjct: 236 PWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR--KNVVPCVL 278 Query: 360 EPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKNRPEIT 415 + +DRG+LA L ++F E R VLKL P LAPIKVA+ E+ Sbjct: 279 SVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELR 338 Query: 416 EYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTT 472 + + L LL G+ L ++ + Y ++DE+ F V V T+ ++G Sbjct: 339 QVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL---ENGLI 395 Query: 473 RLKDTVTVRDRDTMEQIRLHVDELEGFL 500 L R RDT + +H+ +L+ FL Sbjct: 396 HL------RSRDTTMKEMMHISKLKDFL 417 >5C53-B nrPDB Length = 903 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 94/336 (27%), Positives = 146/336 (43%), Gaps = 40/336 (11%) Query: 175 GPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIF 231 GP+ S LR G ++ N LD +++LP+G+AQIG F + RN + Sbjct: 588 GPLLPGDSAFRLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVK 647 Query: 232 RVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKA 291 + E + + +F P W +W+ RL+WW++ +S N EE + Sbjct: 648 SIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRK 703 Query: 292 TVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETG 351 + Y FP G E +E T ++LG H G + +L RD Sbjct: 704 GNKLYYNFPWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR-- 746 Query: 352 KWFVPYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPL 407 K VP V+ + +DRG+LA L ++F E R VLKL P LAPIKVA+ Sbjct: 747 KNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVG 806 Query: 408 VKNRPEITEYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTI 464 E+ + + L LL G+ L ++ + Y ++DE+ F V V T+ Sbjct: 807 RGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL 866 Query: 465 GQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFL 500 ++G L R RDT + +H+ +L+ FL Sbjct: 867 ---ENGLIHL------RSRDTTMKEMMHISKLKDFL 893 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 93/337 (27%), Positives = 148/337 (43%), Gaps = 41/337 (12%) Query: 175 GPV-EDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFI 230 GP+ +++ LR G ++ N LD +++LP+G+AQIG F + RN + Sbjct: 136 GPLLPGDSAFRKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGV 195 Query: 231 FRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAK 290 + E + + +F P W +W+ RL+WW++ +S N EE + Sbjct: 196 KSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GR 251 Query: 291 ATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPET 350 + Y FP G E +E T ++LG H G + +L RD Sbjct: 252 KGNKLYYNFPWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR- 295 Query: 351 GKWFVPYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIP 406 K VP V+ + +DRG+LA L ++F E R VLKL P LAPIKVA+ Sbjct: 296 -KNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDV 354 Query: 407 LVKNRPEITEYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDT 463 E+ + + L LL G+ L ++ + Y ++DE+ F V V T Sbjct: 355 GRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETT 414 Query: 464 IGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFL 500 + ++G L R RDT + +H+ +L+ FL Sbjct: 415 L---ENGLIHL------RSRDTTMKEMMHISKLKDFL 442 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 4/64 (6%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 67 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 126 Query: 63 GLDA 66 +DA Sbjct: 127 PVDA 130 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 4/64 (6%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 519 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 578 Query: 63 GLDA 66 +DA Sbjct: 579 PVDA 582 >3IKL-A nrPDB Length = 459 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 93/332 (28%), Positives = 144/332 (43%), Gaps = 40/332 (12%) Query: 179 DEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIFRVRE 235 D A LR G ++ N LD +++LP+G+AQIG F + RN + + E Sbjct: 142 DSAFRGGLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGE 201 Query: 236 FEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDI 295 + + +F P W +W+ RL+WW++ +S N EE + + Sbjct: 202 KTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRKGNKL 257 Query: 296 LYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFV 355 Y FP G E +E T ++LG H G + +L RD K V Sbjct: 258 YYNFPWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR--KNVV 300 Query: 356 PYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKNR 411 P V+ + +DRG+LA L ++F E R VLKL P LAPIKVA+ Sbjct: 301 PCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPT 360 Query: 412 PEITEYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSK 468 E+ + + L LL G+ L ++ + Y ++DE+ F V V T+ + Sbjct: 361 LELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL---E 417 Query: 469 DGTTRLKDTVTVRDRDTMEQIRLHVDELEGFL 500 +G L R RDT + +H+ +L+ FL Sbjct: 418 NGLIHL------RSRDTTMKEMMHISKLKDFL 443 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/64 (35%), Positives = 35/64 (54%), Gaps = 4/64 (6%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 67 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 126 Query: 63 GLDA 66 +DA Sbjct: 127 PVDA 130 >1G5I-A nrPDB Length = 454 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 96/330 (29%), Positives = 143/330 (43%), Gaps = 42/330 (12%) Query: 186 LRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAF----RNEITPRNFIFRVREFEQMEI 241 LR G ++ N LD +RKLPFG+AQIG F + TP + + RV E + + Sbjct: 139 LRATLLHGALEHYVNCLDLVNRKLPFGLAQIGVCFHPVSNSNQTPSS-VTRVGEKTEASL 197 Query: 242 EYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPH 301 +F W +W+ RL WW++ +S N E + + Y FP Sbjct: 198 VWFTPTRTSSQWLDFWLRHRLLWWRKFAMSPSNFSSADCQDE----LGRKGSKLYYSFPW 253 Query: 302 GLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEP 361 G E +E + N D +L HT I R R K VP V+ Sbjct: 254 GKEPIETLWNLGDQEL-LHTYPGNVSTIQGRDGR----------------KNVVPCVLSV 296 Query: 362 SAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEY 417 S VD G LA L ++F E +R VLKL P LAPIKVA+ E+ + Sbjct: 297 SGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLKLHPCLAPIKVALDVGKGPTVELRQV 356 Query: 418 AKRLKARLLALGLGRVL-YEDT--GNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRL 474 + L LL G+ Y +T ++ + + ++DE+ F+V V T+ ++G +L Sbjct: 357 CQGLLNELLENGISVWPGYSETVHSSLEQLHSKYDEMSVLFSVLVTETTL---ENGLIQL 413 Query: 475 KDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 R RDT + +H+ +L FL + L Sbjct: 414 ------RSRDTTMKEMMHISKLRDFLVKYL 437 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 24/64 (37%), Positives = 34/64 (53%), Gaps = 4/64 (6%) Query: 7 DELVALCKRRGFIF---QSSEIYGGLQGVYD-YGPLGVELKNNLKQAWWRRNVYERDDME 62 + LV LC+RR F+ Q L G + +GPLGVEL+ NL WW V R+ + Sbjct: 25 EALVDLCRRRHFLSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQWWSSMVVFREQVF 84 Query: 63 GLDA 66 +D+ Sbjct: 85 AVDS 88 >1H4S-A nrPDB Length = 477 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/80 (37%), Positives = 46/80 (57%), Gaps = 6/80 (7%) Query: 382 LPNGEERIVLKLKPQLAPIKVAVIPLVKN--RPEITEYAKRLKARLLALGLGRVLYEDTG 439 + +G++R L L P+LAPI+V ++P+ K+ R + E A+ L+ LLA GL RV +D Sbjct: 271 MTHGDDR-GLVLPPRLAPIQVVIVPIYKDESRERVLEAAQGLRQALLAQGL-RVHLDDRD 328 Query: 440 NIGKAYRRHDE--VGTPFAV 457 Y+ H+ G PF V Sbjct: 329 QHTPGYKFHEWELKGVPFRV 348 >4RQF-A nrPDB Length = 522 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 54/227 (23%), Positives = 87/227 (38%), Gaps = 40/227 (17%) Query: 209 LPFGIAQIGKAFRNEITPRN----FIFRVREFEQMEIEYFVRPGEDEYWHRY--WVEERL 262 LP A + FR E+ IFRV +FE++E + P +++ W + + Sbjct: 290 LPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAE 349 Query: 263 KWWQEMGLSRENLVPYQ---QPPEELAHYAKATVDILYRFP--HGLEELEGIANRTDFDL 317 +++Q +G +PY L H A +D+ FP EL +N TD+ Sbjct: 350 EFYQSLG------IPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDY-- 401 Query: 318 GSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAF 377 AR LR + + E FV + R + A+L Sbjct: 402 ------------QARRLRIRYGQTKKMMDKVE----FVHMLNATMCATTRTICAILENYQ 445 Query: 378 TREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKAR 424 T++ + E KLK + P +IP VK P E +K+ K + Sbjct: 446 TKKGITVPE-----KLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQ 487 >1NJ2-A nrPDB Length = 501 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 31/118 (26%), Positives = 52/118 (44%), Gaps = 13/118 (11%) Query: 391 LKLKPQLAPIKVAVIPLV--KNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRH 448 L L P +A +V ++P++ K E+ E + L++RL A G L + G+ Y Sbjct: 306 LCLPPDVAAHQVVIVPIIFKKAAEEVMEACRELRSRLEAAGFRVHLDDRDIRAGRKYYEW 365 Query: 449 DEVGTPFAVTVDYDTIGQSKDGTTRL-KDTVTVRDRDTMEQIRLHVDELEGFLRERLR 505 + G P V + G L K + RDT E++ + +E LRE ++ Sbjct: 366 EMRGVPLRVEI----------GPRDLEKGAAVISRRDTGEKVTADLQGIEETLRELMK 413 >5UCM-A nrPDB Length = 579 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 1/50 (2%) Query: 207 RKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRY 256 ++LP QI FR+EI PR + R REF M+ Y +D Y Sbjct: 134 KQLPINFYQIQTKFRDEIRPRFGLMRGREF-IMKDAYSFHLSQDSLQQTY 182 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 61/144 (42%), Gaps = 22/144 (15%) Query: 364 GVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKA 423 GV R V A + + N +ER +L LAP ++A++PL + + +L A Sbjct: 453 GVSRVVAAAIEQ--------NHDERGIL-WPSALAPFQIALVPLKYETESVKQATDKLYA 503 Query: 424 RLLALGLGRVLYED---TGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTV 480 L A G VL +D + G + + +G P + + S G + + + Sbjct: 504 ELTAAGF-EVLLDDRDKKTSPGVKFADMELIGIPHRIVI-------SDRGLS--EGVLEY 553 Query: 481 RDRDTMEQIRLHVDELEGFLRERL 504 + R E L + EL F+ E+L Sbjct: 554 KGRRDSESQNLPIGELMSFITEKL 577 >1NJ8-A nrPDB Length = 459 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 74/167 (44%), Gaps = 29/167 (17%) Query: 335 RNEHSTQRLAYRDPETGKWFVPYVIEPSAGV-DRGVLALLAEAFTREELPNGEERIVLKL 393 +N T + + P K Y + G+ DR + +++A +G+E+ ++ L Sbjct: 229 QNFSKTFEIIFETPTGDK---DYAYQTCYGISDRVIASIIA--------IHGDEKGLI-L 276 Query: 394 KPQLAPIKVAVIPLVKNRPE--ITEYAKRLKARLLALGLGRVLYEDTG-NIGKAYRRHDE 450 P +API+V ++PL+ E + E AK + +L G RV +D G+ + + Sbjct: 277 PPIVAPIQVVIVPLIFKGKEDIVMEKAKEIYEKL--KGKFRVHIDDRDIRPGRKFNDWEI 334 Query: 451 VGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELE 497 G P + V I K +T+ RDTME + VDE + Sbjct: 335 KGVPLRIEVGPKDIENKK---------ITLFRRDTME--KFQVDETQ 370 >2ZR2-A nrPDB Length = 455 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 13/108 (12%) Query: 170 FKTYVGPVEDEASLAYLRPETAQ---GIFVNFKNVLDATSRKLPFGIAQIGKAFRNEI-- 224 F+ + VEDE YL P G+ N +LD + LP + FR E Sbjct: 235 FEDVIYKVEDED--LYLIPTAEHPLAGMHAN--EILDG--KDLPLLYVGVSPCFRKEAGT 288 Query: 225 --TPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGL 270 IFRV +F ++E + RP E WH + + +QE+ + Sbjct: 289 AGKDTKGIFRVHQFHKVEQFVYSRPEESWEWHEKIIRNAEELFQELEI 336 >2ZTG-A nrPDB Length = 739 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 24/46 (52%) Query: 236 FEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQP 281 FE M F PG++ YW V + E+G+ +E++V ++P Sbjct: 145 FEMMAHHAFNYPGKEIYWKNETVAYCTELLNELGVKKEDIVYKEEP 190 >3WQY-A nrPDB Length = 906 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 24/46 (52%) Query: 236 FEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQP 281 FE M F PG++ YW V + E+G+ +E++V ++P Sbjct: 145 FEMMAHHAFNYPGKEIYWKNETVAYCTELLNELGVKKEDIVYKEEP 190 >3JS4-A nrPDB Length = 227 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 23/37 (62%), Gaps = 2/37 (5%) Query: 54 NVYERDDM--EGLDASVLTHRLVLHYSGHEATFADPM 88 +++E D+ EGL+ + +H L HY+GH T+ D + Sbjct: 21 SMFELSDLPYEGLEPYISSHLLDRHYNGHHKTYVDVL 57 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1ATI-A nrPDB 746 0.0 2PME-A nrPDB 547 e-156 1B76-A nrPDB 519 e-147 5Z5E-A nrPDB 465 e-131 5C52-B nrPDB 459 e-129 3IKM-B nrPDB 459 e-129 1G5I-A nrPDB 423 e-119 5C53-B nrPDB 381 e-106 3IKL-A nrPDB 376 e-104 Sequences not found previously or not previously below threshold: 1NJ8-A nrPDB 49 3e-06 1NJ2-A nrPDB 48 9e-06 1NYR-A nrPDB 44 1e-04 6BLJ-A nrPDB 41 0.001 2ZR2-A nrPDB 41 0.002 6H9X-A nrPDB 41 0.002 5UCM-A nrPDB 40 0.003 6OTE-A nrPDB 39 0.005 3IAL-A nrPDB 39 0.005 3QO8-A nrPDB 38 0.008 1QF6-A nrPDB 38 0.010 4HWO-A nrPDB 37 0.016 1H4S-A nrPDB 37 0.017 2J3M-A nrPDB 35 0.075 3LSS-A nrPDB 33 0.26 6GIR-A nrPDB 33 0.39 1XDV-A nrPDB 33 0.50 2I4O-A nrPDB 32 0.51 5OVF-A nrPDB 32 0.64 3TEV-A nrPDB 32 0.74 4QSZ-A nrPDB 31 1.2 6EIE-A nrPDB 31 1.2 1MG7-A nrPDB 31 1.5 4QU2-A nrPDB 31 1.5 4BMQ-A nrPDB 29 3.6 4P3N-A nrPDB 29 3.8 2A99-A nrPDB 29 5.3 1SOX-A nrPDB 29 6.8 2WMN-A nrPDB 28 7.3 >1ATI-A nrPDB Length = 505 Score = 746 bits (1926), Expect = 0.0, Method: Composition-based stats. Identities = 488/504 (96%), Positives = 489/504 (97%) Query: 3 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 62 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME Sbjct: 2 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 61 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE 122 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE Sbjct: 62 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE 121 Query: 123 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEAS 182 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMF+ GP Sbjct: 122 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFQDLRGPRGGRGL 181 Query: 183 LAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIE 242 LAYLRPETAQGIFVNFKNVLDATSRKL FGIAQIGKAFRNEITPRNFIFRVREFEQMEIE Sbjct: 182 LAYLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEITPRNFIFRVREFEQMEIE 241 Query: 243 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPHG 302 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPE AHYAKATVDILYRFPHG Sbjct: 242 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPESSAHYAKATVDILYRFPHG 301 Query: 303 LEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS 362 ELEGIA RTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS Sbjct: 302 SLELEGIAQRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS 361 Query: 363 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLK 422 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLK Sbjct: 362 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLK 421 Query: 423 ARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRD 482 ARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRD Sbjct: 422 ARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRD 481 Query: 483 RDTMEQIRLHVDELEGFLRERLRW 506 RDTMEQIRLHVDELEGFLRERLRW Sbjct: 482 RDTMEQIRLHVDELEGFLRERLRW 505 >2PME-A nrPDB Length = 693 Score = 547 bits (1410), Expect = e-156, Method: Composition-based stats. Identities = 163/591 (27%), Positives = 253/591 (42%), Gaps = 107/591 (18%) Query: 11 ALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDMEGLDASVLT 70 KRR F Q+ IYGG+ G+YD+GP+G LKNN+ Q W + + E +E +D ++LT Sbjct: 72 DTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILE-IDCTMLT 130 Query: 71 HRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEENLHALV 130 VL SGH FAD MV + + +R DHLLK ++++ ++E + E L Sbjct: 131 PEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLA 190 Query: 131 QAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASLAYLRPET 190 Q + V P +G D +PP FN+MFKT++GP + YLRPET Sbjct: 191 QLDNYGQQELADLFVNYNVKSPITG--NDLSPPVSFNLMFKTFIGPGGNMP--GYLRPET 246 Query: 191 AQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIEYFVRPGED 250 AQGIF+NFK +L+ KLPF AQIG +FRNEI+PR+ + RVREF EIE+FV P E Sbjct: 247 AQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEK 306 Query: 251 EY--------WHRYWVEERLK----------------------------------WWQEM 268 ++ H Y + + + ++ Sbjct: 307 DHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKV 366 Query: 269 GLSRENLVPYQQPPEELAHYAKATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALG 328 G+S + L Q E+AHYA D + +G E+ G A+R+ +DL H + + Sbjct: 367 GISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPL 426 Query: 329 ITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEER 388 + + L+ E T + +P G Y + A + LA+ E + E E+ Sbjct: 427 VAEKPLK-EPKTVNVVQFEPSKGAIGKAY--KKDAKLVMEYLAICDECYITEMEMLLNEK 483 Query: 389 IVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLA--LGLGRVLYE--------DT 438 ++ + ++ + R + T Y + + ++ GLGR++Y Sbjct: 484 GEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVRE 543 Query: 439 GNIGKAYRRHDEVGTPFAVTV--------------------------------------- 459 G+ + + V PF +V Sbjct: 544 GDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRR 603 Query: 460 --DYDTIGQS------KDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRE 502 D IG + D + T T+RDRD+M QIR + EL +++ Sbjct: 604 YARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQD 654 >1B76-A nrPDB Length = 442 Score = 519 bits (1336), Expect = e-147, Method: Composition-based stats. Identities = 331/347 (95%), Positives = 332/347 (95%) Query: 160 WTPPRYFNMMFKTYVGPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKA 219 WTPPRYFNMMF+ GP LAYLRPETAQGIFVNFKNVLDATSRKL FGIAQIGKA Sbjct: 96 WTPPRYFNMMFQDLRGPRGGRGLLAYLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKA 155 Query: 220 FRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ 279 FRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ Sbjct: 156 FRNEITPRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQ 215 Query: 280 QPPEELAHYAKATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHS 339 QPPE AHYAKATVDILYRFPHG ELEGIA RTDFDLGSHTKDQEALGITARVLRNEHS Sbjct: 216 QPPESSAHYAKATVDILYRFPHGSLELEGIAQRTDFDLGSHTKDQEALGITARVLRNEHS 275 Query: 340 TQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAP 399 TQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAP Sbjct: 276 TQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAP 335 Query: 400 IKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTV 459 IKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTV Sbjct: 336 IKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTV 395 Query: 460 DYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERLRW 506 DYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERLRW Sbjct: 396 DYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERLRW 442 Score = 151 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 89/93 (95%), Positives = 90/93 (96%) Query: 3 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 62 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME Sbjct: 2 ASSLDELVALCKRRGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDME 61 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITK 95 GLDASVLTHRLVLHYSGHEATFADPMVDN + Sbjct: 62 GLDASVLTHRLVLHYSGHEATFADPMVDNAKAR 94 >5Z5E-A nrPDB Length = 534 Score = 465 bits (1196), Expect = e-131, Method: Composition-based stats. Identities = 179/552 (32%), Positives = 271/552 (49%), Gaps = 120/552 (21%) Query: 16 RGFIFQSSEIYGGLQGVYDYGPLGVELKNNLKQAWWRRNVYERDDMEGLDASVLTHRLVL 75 +GF + +SEIY + G YDYG LG LKNN W + + +D +++ + V Sbjct: 31 KGFFYPASEIYNSIAGFYDYGYLGTLLKNNFINEWKNYFLRLHPNFWEVDPAIVMPKEVF 90 Query: 76 HYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEENLHALVQAMMQ 135 SGH F DP+V+ + R+R DHL++E+ + ++ E L ++ + Sbjct: 91 IASGHLENFNDPIVECK-NGHRFRADHLIEEK-----------LNIKAEGL-----SLSE 133 Query: 136 APERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEA-------------- 181 E V P P ++FN+MF Y+GP EA Sbjct: 134 MEE------LLKNVRCPICNAP--LGKVKWFNLMFPIYIGPDSQEALNLLKNLKENVSEQ 185 Query: 182 --------------SLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPR 227 + AYLRPETAQG +V FK +KLP G+A +GKAFRNEI+PR Sbjct: 186 YIKDIIERVKKMVENEAYLRPETAQGPYVMFKREFILHRQKLPLGLAVVGKAFRNEISPR 245 Query: 228 NFIFRVREFEQMEIEYFVRPGEDEY-------------------------------WHRY 256 + R+REF Q E++ F P ++E+ ++ Y Sbjct: 246 QLLLRLREFTQAELQIFFDPEDNEFDINEVKDVELNFLDKEGNYKRIKVKDLPFPEFYAY 305 Query: 257 WVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFP-HGLEELEGIANRTDF 315 +V + ++++ +G+ E L + +E A Y K VDI FP +G +E+ GI RTD Sbjct: 306 FVGKVKQFYERLGIPEERLRFRELSEKEKAFYNKYHVDIEINFPTYGWKEVGGIHYRTDH 365 Query: 316 DLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAE 375 DL H K ++ + L + + K F+P+V+E S GVDR VLAL+ Sbjct: 366 DLSGHMK------VSGKDLTVQ-----------KDNKKFIPHVLELSFGVDRNVLALIDL 408 Query: 376 AFTREEL-------PNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLAL 428 T EE E+R+VLK+ LAPIKVAV PL+K +PE+ E AK + +L Sbjct: 409 FLTEEEYEIERDNQKVKEKRVVLKIPKHLAPIKVAVFPLLK-KPELIEKAKEV-YNMLKN 466 Query: 429 GLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQ 488 ++Y++ G+IG+ YRR DE+G P+A+T+DY T+ +TVT+RDRDTM+Q Sbjct: 467 YFYPIIYDEQGSIGRRYRRVDEIGVPYAITIDYQTLED---------NTVTIRDRDTMKQ 517 Query: 489 IRLHVDELEGFL 500 +R+ +++L L Sbjct: 518 VRVKIEDLPNQL 529 >5C52-B nrPDB Length = 485 Score = 459 bits (1181), Expect = e-129, Method: Composition-based stats. Identities = 124/511 (24%), Positives = 202/511 (39%), Gaps = 113/511 (22%) Query: 8 ELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDMEG 63 L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 68 ALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFP 127 Query: 64 LDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEE 123 +DA LH+ P++ D + E L+ + + E+ + Sbjct: 128 VDA--------LHHK------PGPLLPG---------DSAFRLVSAETLREILQDKELSK 164 Query: 124 ENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASL 183 E L A ++ +++ Sbjct: 165 EQLVAFLENVLKTS---------------------------------------------- 178 Query: 184 AYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIFRVREFEQME 240 LR G ++ N LD +++LP+G+AQIG F + RN + + E + Sbjct: 179 GKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEAS 238 Query: 241 IEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFP 300 + +F P W +W+ RL+WW++ +S N EE + + Y FP Sbjct: 239 LVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRKGNKLYYNFP 294 Query: 301 HGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIE 360 G E +E T ++LG H G + +L RD K VP V+ Sbjct: 295 WGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR--KNVVPCVLS 337 Query: 361 PSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKNRPEITE 416 + +DRG+LA L ++F E R VLKL P LAPIKVA+ E+ + Sbjct: 338 VNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQ 397 Query: 417 YAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTR 473 + L LL G+ L ++ + Y ++DE+ F V V T+ ++G Sbjct: 398 VCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL---ENGLIH 454 Query: 474 LKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 L R RDT + +H+ +L+ FL + + Sbjct: 455 L------RSRDTTMKEMMHISKLKDFLIKYI 479 >3IKM-B nrPDB Length = 427 Score = 459 bits (1180), Expect = e-129, Method: Composition-based stats. Identities = 124/512 (24%), Positives = 203/512 (39%), Gaps = 113/512 (22%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 9 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 68 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVE 122 +DA LH+ P++ D + E L+ + + E+ Sbjct: 69 PVDA--------LHHK------PGPLLPG---------DSAFRLVSAETLREILQDKELS 105 Query: 123 EENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEAS 182 +E L A ++ +++ Sbjct: 106 KEQLVAFLENVLKTS--------------------------------------------- 120 Query: 183 LAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIFRVREFEQM 239 LR G ++ N LD +++LP+G+AQIG F + RN + + E + Sbjct: 121 -GKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEA 179 Query: 240 EIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRF 299 + +F P W +W+ RL+WW++ +S N EE + + Y F Sbjct: 180 SLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRKGNKLYYNF 235 Query: 300 PHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVI 359 P G E +E T ++LG H G + +L RD K VP V+ Sbjct: 236 PWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR--KNVVPCVL 278 Query: 360 EPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKNRPEIT 415 + +DRG+LA L ++F E R VLKL P LAPIKVA+ E+ Sbjct: 279 SVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELR 338 Query: 416 EYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTT 472 + + L LL G+ L ++ + Y ++DE+ F V V T+ ++G Sbjct: 339 QVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL---ENGLI 395 Query: 473 RLKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 L R RDT + +H+ +L+ FL + + Sbjct: 396 HL------RSRDTTMKEMMHISKLKDFLIKYI 421 >1G5I-A nrPDB Length = 454 Score = 423 bits (1087), Expect = e-119, Method: Composition-based stats. Identities = 127/517 (24%), Positives = 196/517 (37%), Gaps = 115/517 (22%) Query: 3 ASSLDELVALCKRRGFIF---QSSEIYGGLQGVYD-YGPLGVELKNNLKQAWWRRNVYER 58 A + + LV LC+RR F+ Q L G + +GPLGVEL+ NL WW V R Sbjct: 21 AVAREALVDLCRRRHFLSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQWWSSMVVFR 80 Query: 59 DDMEGLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYRA 118 + + +D+ D + E ++ + + Sbjct: 81 EQVFAVDSLHQEP-----------------------GSSQPRDSAFRLVSPESIREILQD 117 Query: 119 MEVEEENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPVE 178 E +E L A ++ +++ Sbjct: 118 REPSKEQLVAFLENLLKTS----------------------------------------- 136 Query: 179 DEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR----NEITPRNFIFRVR 234 LR G ++ N LD +RKLPFG+AQIG F + TP + + RV Sbjct: 137 -----GKLRATLLHGALEHYVNCLDLVNRKLPFGLAQIGVCFHPVSNSNQTPSS-VTRVG 190 Query: 235 EFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVD 294 E + + +F W +W+ RL WW++ +S N E + Sbjct: 191 EKTEASLVWFTPTRTSSQWLDFWLRHRLLWWRKFAMSPSNFSSADCQDE----LGRKGSK 246 Query: 295 ILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWF 354 + Y FP G E +E + N D +L HT I R R K Sbjct: 247 LYYSFPWGKEPIETLWNLGDQEL-LHTYPGNVSTIQGRDGR----------------KNV 289 Query: 355 VPYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPLVKN 410 VP V+ S VD G LA L ++F E +R VLKL P LAPIKVA+ Sbjct: 290 VPCVLSVSGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLKLHPCLAPIKVALDVGKGP 349 Query: 411 RPEITEYAKRLKARLLALGLGRVL-YEDT--GNIGKAYRRHDEVGTPFAVTVDYDTIGQS 467 E+ + + L LL G+ Y +T ++ + + ++DE+ F+V V T+ Sbjct: 350 TVELRQVCQGLLNELLENGISVWPGYSETVHSSLEQLHSKYDEMSVLFSVLVTETTL--- 406 Query: 468 KDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 ++G +L R RDT + +H+ +L FL + L Sbjct: 407 ENGLIQL------RSRDTTMKEMMHISKLRDFLVKYL 437 >5C53-B nrPDB Length = 903 Score = 381 bits (977), Expect = e-106, Method: Composition-based stats. Identities = 94/340 (27%), Positives = 148/340 (43%), Gaps = 40/340 (11%) Query: 175 GPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFIF 231 GP+ S LR G ++ N LD +++LP+G+AQIG F + RN + Sbjct: 588 GPLLPGDSAFRLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVK 647 Query: 232 RVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKA 291 + E + + +F P W +W+ RL+WW++ +S N EE + Sbjct: 648 SIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GRK 703 Query: 292 TVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETG 351 + Y FP G E +E T ++LG H G + +L RD Sbjct: 704 GNKLYYNFPWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR-- 746 Query: 352 KWFVPYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIPL 407 K VP V+ + +DRG+LA L ++F E R VLKL P LAPIKVA+ Sbjct: 747 KNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVG 806 Query: 408 VKNRPEITEYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTI 464 E+ + + L LL G+ L ++ + Y ++DE+ F V V T+ Sbjct: 807 RGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTL 866 Query: 465 GQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 ++G L R RDT + +H+ +L+ FL + + Sbjct: 867 ---ENGLIHL------RSRDTTMKEMMHISKLKDFLIKYI 897 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 94/341 (27%), Positives = 148/341 (43%), Gaps = 41/341 (12%) Query: 175 GPVEDEASLAY-LRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNFI 230 GP+ S LR G ++ N LD +++LP+G+AQIG F + RN + Sbjct: 136 GPLLPGDSAFRKLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGV 195 Query: 231 FRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAK 290 + E + + +F P W +W+ RL+WW++ +S N EE + Sbjct: 196 KSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----GR 251 Query: 291 ATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPET 350 + Y FP G E +E T ++LG H G + +L RD Sbjct: 252 KGNKLYYNFPWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR- 295 Query: 351 GKWFVPYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVIP 406 K VP V+ + +DRG+LA L ++F E R VLKL P LAPIKVA+ Sbjct: 296 -KNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDV 354 Query: 407 LVKNRPEITEYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDT 463 E+ + + L LL G+ L ++ + Y ++DE+ F V V T Sbjct: 355 GRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETT 414 Query: 464 IGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 + ++G L R RDT + +H+ +L+ FL + + Sbjct: 415 L---ENGLIHL------RSRDTTMKEMMHISKLKDFLIKYI 446 Score = 88.8 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 18/101 (17%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 67 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 126 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHL 103 +DA LH+ P++ ++ R + L Sbjct: 127 PVDA--------LHHK------PGPLLPGDSAFRKLRENLL 153 Score = 87.2 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 18/89 (20%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 519 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 578 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDN 91 +DA LH+ P++ Sbjct: 579 PVDA--------LHHK------PGPLLPG 593 >3IKL-A nrPDB Length = 459 Score = 376 bits (966), Expect = e-104, Method: Composition-based stats. Identities = 94/342 (27%), Positives = 148/342 (43%), Gaps = 42/342 (12%) Query: 175 GPVEDEASLAY--LRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFR---NEITPRNF 229 GP+ S LR G ++ N LD +++LP+G+AQIG F + RN Sbjct: 136 GPLLPGDSAFRGGLRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNG 195 Query: 230 IFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYA 289 + + E + + +F P W +W+ RL+WW++ +S N EE Sbjct: 196 VKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFSSSDCQDEE----G 251 Query: 290 KATVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPE 349 + + Y FP G E +E T ++LG H G + +L RD Sbjct: 252 RKGNKLYYNFPWGKELIE-----TLWNLGDHELLHMYPG----------NVSKLHGRDGR 296 Query: 350 TGKWFVPYVIEPSAGVDRGVLALLAEAFTREELP----NGEERIVLKLKPQLAPIKVAVI 405 K VP V+ + +DRG+LA L ++F E R VLKL P LAPIKVA+ Sbjct: 297 --KNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALD 354 Query: 406 PLVKNRPEITEYAKRLKARLLALGLG---RVLYEDTGNIGKAYRRHDEVGTPFAVTVDYD 462 E+ + + L LL G+ L ++ + Y ++DE+ F V V Sbjct: 355 VGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTET 414 Query: 463 TIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 T+ ++G L R RDT + +H+ +L+ FL + + Sbjct: 415 TL---ENGLIHL------RSRDTTMKEMMHISKLKDFLIKYI 447 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 18/89 (20%) Query: 7 DELVALCKRRGFIFQSSEIYGG---LQGVY-DYGPLGVELKNNLKQAWWRRNVYERDDME 62 + L+ +C+RR F+ S + L G + +GPLGVEL+ NL WW V R+ + Sbjct: 67 EALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVF 126 Query: 63 GLDASVLTHRLVLHYSGHEATFADPMVDN 91 +DA LH+ P++ Sbjct: 127 PVDA--------LHHK------PGPLLPG 141 >1NJ8-A nrPDB Length = 459 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 119/335 (35%), Gaps = 51/335 (15%) Query: 175 GPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVR 234 G LRP + I+ K + + LP I QI FR E + R+R Sbjct: 91 GGKTQLDVKLALRPTSETPIYYMMKLWVKVHT-DLPIKIYQIVNTFRYETKHTRPLIRLR 149 Query: 235 E---FEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKA 291 E F++ + + + + K++ +G+ + ++P + A+ Sbjct: 150 EIMTFKEAHTAHSTKEEAENQVKEA-ISIYKKFFDTLGIP---YLISKRPEWDKFPGAEY 205 Query: 292 TVDILYRFPHGLEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETG 351 T+ FP G + T +LG +N T + + P Sbjct: 206 TMAFDTIFPDGR----TMQIATVHNLG----------------QNFSKTFEIIFETPTGD 245 Query: 352 KWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNR 411 K Y + G+ V+A + G+E+ L L P +API+V ++PL+ Sbjct: 246 KD---YAYQTCYGISDRVIASIIAIH-------GDEKG-LILPPIVAPIQVVIVPLIFKG 294 Query: 412 PE--ITEYAKRLKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKD 469 E + E AK + L + + G+ + + G P + V I K Sbjct: 295 KEDIVMEKAKEI-YEKLKGKFRVHIDDRDIRPGRKFNDWEIKGVPLRIEVGPKDIENKKI 353 Query: 470 GTTRLKDTVTVRDRDTMEQIRLHVDELEGFLRERL 504 R RDTME+ ++ +L + + L Sbjct: 354 TLFR---------RDTMEKFQVDETQLMEVVEKTL 379 >1NJ2-A nrPDB Length = 501 Score = 48.3 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 113/325 (34%), Gaps = 50/325 (15%) Query: 186 LRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVRE---FEQMEIE 242 LRP + ++ F + + + LP Q+ FR E + RVRE F++ Sbjct: 134 LRPTSETVMYPMFALWVRSHT-DLPMRFYQVVNTFRYETKHTRPLIRVREITTFKEAHTI 192 Query: 243 YFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPHG 302 + +E R VE +++ +G+ + ++PP + ++ TV P G Sbjct: 193 HATASEAEEQVERA-VEIYKEFFNSLGIP---YLITRRPPWDKFPGSEYTVAFDTLMPDG 248 Query: 303 LEELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPS 362 G T +LG A + E + + + VI Sbjct: 249 KTLQIG----TVHNLG----QTFARTFEIKFETPEGDHEYVHQTCYGLSDRVIASVIAIH 300 Query: 363 AGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRP--EITEYAKR 420 L L P +A +V ++P++ + E+ E + Sbjct: 301 GD-----------------------ESGLCLPPDVAAHQVVIVPIIFKKAAEEVMEACRE 337 Query: 421 LKARLLALGLGRVLYEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTV 480 L++RL A G L + G+ Y + G P V + + K + Sbjct: 338 LRSRLEAAGFRVHLDDRDIRAGRKYYEWEMRGVPLRVEIGPRDLE---------KGAAVI 388 Query: 481 RDRDTMEQIRLHVDELEGFLRERLR 505 RDT E++ + +E LRE ++ Sbjct: 389 SRRDTGEKVTADLQGIEETLRELMK 413 >1NYR-A nrPDB Length = 645 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 105/309 (33%), Gaps = 29/309 (9%) Query: 207 RKLPFGIAQIGKAFRNEIT-PRNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWW 265 R+LP IA++G R E + + + RVR + FVRP + + + V + + Sbjct: 351 RELPIRIAELGTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVY 410 Query: 266 QEMGLSRE--NLVPYQQPPEELAHYAKATVDILYRFPHGLEELEGIANRTDFDLGSHTKD 323 ++ G L +E + E + + + +G Sbjct: 411 KDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENML--KEAADELGLSYEEAIGEAAFY 468 Query: 324 QEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAG------VDRGVLALLAEAF 377 L + + + T A D + F I + RGV++ + Sbjct: 469 GPKLDVQVKTAMGKEETLSTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSTMERFV 528 Query: 378 T-REELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYE 436 E G LAP +V +IP+ + +YA++L+ L + G+ + + Sbjct: 529 AFLTEETKG------AFPTWLAPKQVQIIPVNVDLH--YDYARQLQDELKSQGVRVSIDD 580 Query: 437 DTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDEL 496 +G R P+ + V + + V VR + +Q + DE Sbjct: 581 RNEKMGYKIREAQMQKIPYQIVVGDKEVEN---------NQVNVRQYGSQDQETVEKDEF 631 Query: 497 EGFLRERLR 505 L + +R Sbjct: 632 IWNLVDEIR 640 >6BLJ-A nrPDB Length = 485 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 52/149 (34%), Gaps = 15/149 (10%) Query: 179 DEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRN----FIFRVR 234 E YL + Q F +LP + FR E+ IFRV Sbjct: 273 GEGEDKYLIATSEQ-PIAAFHLEKRFDESELPIKYCGMSTCFRKEVGAHGKDTLGIFRVH 331 Query: 235 EFEQMEIEYFVRPGEDEYWHRY--WVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKAT 292 +FE++E P +++ W + + ++Q +G+ L + A Sbjct: 332 QFEKIEQFVVTSPKDNKSWEMFDEMIGNSEAFYQSLGIP---YRVVNIVSGALNNAAAKK 388 Query: 293 VDILYRFPHGLE-----ELEGIANRTDFD 316 D+ FP E EL +N TD+ Sbjct: 389 FDLEAWFPGADEGNEYRELVSCSNCTDYQ 417 >2ZR2-A nrPDB Length = 455 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 51/143 (35%), Gaps = 10/143 (6%) Query: 180 EASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEI----TPRNFIFRVRE 235 E YL P + N + + LP + FR E IFRV + Sbjct: 243 EDEDLYLIPTAEHPLAGMHANEI-LDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVHQ 301 Query: 236 FEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDI 295 F ++E + RP E WH + + +QE+ + +L + A DI Sbjct: 302 FHKVEQFVYSRPEESWEWHEKIIRNAEELFQELEIP---YRVVNICTGDLGYVAAKKYDI 358 Query: 296 LYRFP-HGL-EELEGIANRTDFD 316 P G E+ +N TD+ Sbjct: 359 EAWMPGQGKFREVVSASNCTDWQ 381 >6H9X-A nrPDB Length = 430 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 56/160 (35%), Gaps = 10/160 (6%) Query: 163 PRYFNMMFKTYVGPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRN 222 P++ +F T E ++S L P TA+ N LP + FR+ Sbjct: 211 PKFAGDLFHTRPLEEEADSSNYALIP-TAEVPLTNLVRDEIIDEDDLPIKMTAHTPCFRS 269 Query: 223 EITP----RNFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPY 278 E + R+ +F+++E+ VRP + K Q +GL Sbjct: 270 EAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLP---YRKV 326 Query: 279 QQPPEELAHYAKATVDILYRFP--HGLEELEGIANRTDFD 316 ++ A T D+ P + E+ +N DF Sbjct: 327 ALCTGDMGFSACKTYDLEVWVPAQNTYREISSCSNVWDFQ 366 >5UCM-A nrPDB Length = 579 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 20/74 (27%), Positives = 32/74 (43%), Gaps = 4/74 (5%) Query: 207 RKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIEYFVRPGED-EYWHRYWVEERLKWW 265 ++LP QI FR+EI PR + R REF + F + + + + K + Sbjct: 134 KQLPINFYQIQTKFRDEIRPRFGLMRGREFIMKDAYSFHLSQDSLQQTYDGMYQAYSKIF 193 Query: 266 QEMGLSRENLVPYQ 279 +GL + P Q Sbjct: 194 SRLGL---DFRPVQ 204 >6OTE-A nrPDB Length = 572 Score = 39.1 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 52/142 (36%), Gaps = 10/142 (7%) Query: 181 ASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRN----FIFRVREF 236 ++ +L + Q I NV + LP A I FR E IFR+ +F Sbjct: 360 SNSLFLIATSEQPIAAMHHNV-TLEDKDLPIKYAGISTCFRKEAGAHGKDTWGIFRIHQF 418 Query: 237 EQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDIL 296 E++E P + + H + +++Q + L L A D+ Sbjct: 419 EKVEQFCVTLPEDSQKIHEEMISISEEFYQSLELP---YRVISIVSGALNDAASKKYDLE 475 Query: 297 YRFP--HGLEELEGIANRTDFD 316 FP + EL +N TD+ Sbjct: 476 AWFPGYNSYRELVSCSNCTDYQ 497 >3IAL-A nrPDB Length = 518 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 98/311 (31%), Gaps = 48/311 (15%) Query: 170 FKTYVGPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNF 229 F G ++ LRP + I+ F + + + LP I Q FR+E Sbjct: 103 FWVEKGGLQPLEERLALRPTSETAIYSMFSKWVRSY-KDLPLKIHQTCTIFRHETKNTKP 161 Query: 230 IFRVRE--FEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAH 287 + RVRE + + + YW + E+ + L Sbjct: 162 LIRVREIHWNEAHCCHATAEDAVSQLSDYWKVIDTIFSDELCFKGQKLR----------- 210 Query: 288 YAKATVDILYRFPHGLE-ELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYR 346 + D + ++ R G H Q ST + Y Sbjct: 211 --RVCWDRFPGADYSEVSDVVMPCGRVLQTAGIHNLGQRFS-----------STFDILYA 257 Query: 347 DPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIP 406 + + + PY+ AG+ VLA L + L L P +API V +IP Sbjct: 258 N-KANESVHPYL--TCAGISTRVLAC--------ALSIHGDSGGLVLPPLIAPIHVVIIP 306 Query: 407 ---LVKNRPEITEYAKRLKARLL-----ALGLGRVLYED-TGNIGKAYRRHDEVGTPFAV 457 KN E + + LGL + +D + ++G ++ G P + Sbjct: 307 IGCGKKNNQESDQQVLGKVNEIADTLKSKLGLRVSIDDDFSKSMGDKLYYYELKGVPLRI 366 Query: 458 TVDYDTIGQSK 468 V + + Sbjct: 367 EVGQRDLANGQ 377 >3QO8-A nrPDB Length = 485 Score = 38.3 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 29/121 (23%), Positives = 45/121 (37%), Gaps = 9/121 (7%) Query: 202 LDATSRKLPFGIAQIGKAFRNEITPRN----FIFRVREFEQMEIEYFVRPGEDEYWHRYW 257 ++ + +LP A FR E IFRV FE++E P + Sbjct: 260 FESPAEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQFVLTEPEKSWEEFDRM 319 Query: 258 VEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPHGLE--ELEGIANRTDF 315 + +++Q +GL EL + A D+ FP E EL +N TD+ Sbjct: 320 IGCSEEFYQSLGLP---YRVVGIVSGELNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDY 376 Query: 316 D 316 Sbjct: 377 Q 377 >1QF6-A nrPDB Length = 642 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 77/426 (18%), Positives = 132/426 (30%), Gaps = 45/426 (10%) Query: 90 DNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEENLHALVQAMMQAPERAGGAMTAAGV 149 D+R K+ L H+ +E P V E + + + G V Sbjct: 243 DHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRV 302 Query: 150 LDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKL 209 L +G + Y + MF T E ++P G F L + R L Sbjct: 303 LWEKTGHWDN-----YKDAMFTT-----SSENREYCIKPMNCPGHVQIFNQGLKSY-RDL 351 Query: 210 PFGIAQIGKAFRNEITPR-NFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEM 268 P +A+ G RNE + + + RVR F Q + F + + + Sbjct: 352 PLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTF 411 Query: 269 GLSRENLVPYQQPPE---ELAHYAKATVDI-----LYRFPHGLEELEGIANRTDFDLGSH 320 G + + +P + + +A D+ P + EG + + Sbjct: 412 GFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLY 471 Query: 321 TKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAF-TR 379 A L ++ A E + VP +I R +L + Sbjct: 472 DCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIH------RAILGSMERFIGIL 525 Query: 380 EELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTG 439 E G LAP++V ++ +EY L +L G+ Sbjct: 526 TEEFAGF------FPTWLAPVQV---VIMNITDSQSEYVNELTQKLSNAGIRVKADLRNE 576 Query: 440 NIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGF 499 IG R H P+ + + K V VR R + + V+E+ Sbjct: 577 KIGFKIREHTLRRVPYMLVCGDKEVESGK---------VAVRTRRGKDLGSMDVNEVIEK 627 Query: 500 LRERLR 505 L++ +R Sbjct: 628 LQQEIR 633 >4HWO-A nrPDB Length = 411 Score = 37.2 bits (84), Expect = 0.016, Method: Composition-based stats. Identities = 77/426 (18%), Positives = 132/426 (30%), Gaps = 45/426 (10%) Query: 90 DNRITKKRYRLDHLLKEQPEEVLKRLYRAMEVEEENLHALVQAMMQAPERAGGAMTAAGV 149 D+R K+ L H+ +E P V E + + + G V Sbjct: 4 DHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRV 63 Query: 150 LDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASLAYLRPETAQGIFVNFKNVLDATSRKL 209 L +G + Y + MF T E ++P G F L + R L Sbjct: 64 LWEKTGHWDN-----YKDAMFTT-----SSENREYCIKPMNCPGHVQIFNQGLKSY-RDL 112 Query: 210 PFGIAQIGKAFRNEITPR-NFIFRVREFEQMEIEYFVRPGEDEYWHRYWVEERLKWWQEM 268 P +A+ G RNE + + + RVR F Q + F + + + Sbjct: 113 PLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTF 172 Query: 269 GLSRENLVPYQQPPE---ELAHYAKATVDI-----LYRFPHGLEELEGIANRTDFDLGSH 320 G + + +P + + +A D+ P + EG + + Sbjct: 173 GFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLY 232 Query: 321 TKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAF-TR 379 A L ++ A E + VP +I R +L + Sbjct: 233 DCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIH------RAILGSMERFIGIL 286 Query: 380 EELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLGRVLYEDTG 439 E G LAP++V ++ +EY L +L G+ Sbjct: 287 TEEFAGF------FPTWLAPVQV---VIMNITDSQSEYVNELTQKLSNAGIRVKADLRNE 337 Query: 440 NIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVDELEGF 499 IG R H P+ + + K V VR R + + V+E+ Sbjct: 338 KIGFKIREHTLRRVPYMLVCGDKEVESGK---------VAVRTRRGKDLGSMDVNEVIEK 388 Query: 500 LRERLR 505 L++ +R Sbjct: 389 LQQEIR 394 >1H4S-A nrPDB Length = 477 Score = 37.2 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 26/70 (37%), Positives = 38/70 (54%), Gaps = 3/70 (4%) Query: 391 LKLKPQLAPIKVAVIPLVK--NRPEITEYAKRLKARLLALGLGRVLYE-DTGNIGKAYRR 447 L L P+LAPI+V ++P+ K +R + E A+ L+ LLA GL L + D G + Sbjct: 279 LVLPPRLAPIQVVIVPIYKDESRERVLEAAQGLRQALLAQGLRVHLDDRDQHTPGYKFHE 338 Query: 448 HDEVGTPFAV 457 + G PF V Sbjct: 339 WELKGVPFRV 348 >2J3M-A nrPDB Length = 572 Score = 35.2 bits (79), Expect = 0.075, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 30/65 (46%), Gaps = 1/65 (1%) Query: 207 RKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIEYF-VRPGEDEYWHRYWVEERLKWW 265 ++LP + QI +R+E R+ + R REF + F + +R + + + + Sbjct: 126 KRLPLNLYQIQTKYRDEKRSRSGLLRGREFIMKDGYSFHADEASLDQSYRDYEKAYSRIF 185 Query: 266 QEMGL 270 + GL Sbjct: 186 ERCGL 190 >3LSS-A nrPDB Length = 484 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 29/135 (21%), Positives = 48/135 (35%), Gaps = 11/135 (8%) Query: 190 TAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRN----FIFRVREFEQMEIEYFV 245 T++ + T K P A + FR E IFRV +F+++E Sbjct: 269 TSEMPIAAYHRGRWFTELKEPLKYAGMSTCFRKEAGAHGRDTLGIFRVHQFDKIEQFVVC 328 Query: 246 RPGEDEYW--HRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPH-- 301 P ++E W + ++ + +GL L + A D+ FP Sbjct: 329 SPRQEESWRHLEDMITTSEEFNKSLGLP---YRVVNICSGALNNAAAKKYDLEAWFPASG 385 Query: 302 GLEELEGIANRTDFD 316 EL +N TD+ Sbjct: 386 AFRELVSCSNCTDYQ 400 >6GIR-A nrPDB Length = 456 Score = 32.5 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 32/146 (21%), Positives = 50/146 (34%), Gaps = 12/146 (8%) Query: 179 DEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRN----FIFRVR 234 E YL TA+ + +LP A FR E IFRV Sbjct: 228 GEGDDKYLIA-TAEQPLCAYHIDEWIHPTELPLRYAGYSSCFRKEAGSHGRDTLGIFRVH 286 Query: 235 EFEQMEIEYFVRPGEDEYW--HRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKAT 292 +FE++E P E+ W ++ ++Q + L + + + A Sbjct: 287 QFEKIEQFCITGPNENASWEMLDEMMKNSEDFYQALKLPYQIVSIVSGALNDAA---AKK 343 Query: 293 VDILYRFPHG--LEELEGIANRTDFD 316 D+ FP EL +N TD+ Sbjct: 344 YDLEAWFPSSETFRELVSCSNCTDYQ 369 >1XDV-A nrPDB Length = 847 Score = 32.5 bits (72), Expect = 0.50, Method: Composition-based stats. Identities = 19/77 (24%), Positives = 32/77 (41%), Gaps = 2/77 (2%) Query: 50 WWRRNVYERDDMEGLDASVLTHRLVLHYSGHEATFADPM--VDNRITKKRYRLDHLLKEQ 107 W+ + + E +++E A V +L F + V + YRLDH ++ Sbjct: 637 WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI 696 Query: 108 PEEVLKRLYRAMEVEEE 124 P K L A E+ E+ Sbjct: 697 PSRQKKILEEAHELSED 713 >2I4O-A nrPDB Length = 458 Score = 32.1 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 18/65 (27%), Positives = 26/65 (40%), Gaps = 1/65 (1%) Query: 207 RKLPFGIAQIGKAFRNEITPRNFIFRVREFEQMEIEYF-VRPGEDEYWHRYWVEERLKWW 265 + LP + I FR+E PR + R REF + F V + L+ + Sbjct: 146 KSLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDVDEAGARKSYNKMFVAYLRTF 205 Query: 266 QEMGL 270 MGL Sbjct: 206 ARMGL 210 >5OVF-A nrPDB Length = 490 Score = 32.1 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 19/77 (24%), Positives = 32/77 (41%), Gaps = 2/77 (2%) Query: 50 WWRRNVYERDDMEGLDASVLTHRLVLHYSGHEATFADPM--VDNRITKKRYRLDHLLKEQ 107 W+ + + E +++E A V +L F + V + YRLDH ++ Sbjct: 275 WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI 334 Query: 108 PEEVLKRLYRAMEVEEE 124 P K L A E+ E+ Sbjct: 335 PSRQKKILEEAHELSED 351 >3TEV-A nrPDB Length = 351 Score = 31.8 bits (70), Expect = 0.74, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 21/48 (43%), Gaps = 4/48 (8%) Query: 147 AGVLDPASGEPGDWTPPRYFNMMFKTYVGPVEDEASLAYLRPETAQGI 194 + + P S EP P R ++ GP D+ + AYLR GI Sbjct: 1 SNAMSPIS-EPSRLDPVRPGQLLMIDLPGPELDKDTAAYLRE---HGI 44 >4QSZ-A nrPDB Length = 687 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 53/174 (30%), Gaps = 22/174 (12%) Query: 244 FVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPHGL 303 FV P E R + L + L +Q + DI P Sbjct: 470 FVMPAER----RLPISHVLDVLEGRAQHPGVLYVQKQCSNLPTELPQLLSDIESHVPWAS 525 Query: 304 EELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSA 363 E L + + +F LG + L S ++ P + + F+PY + Sbjct: 526 ESLGKMPDAVNFWLGDASAVTSLHKDHYENLYCVVSGEKHFLLHPPSDRPFIPYNL---- 581 Query: 364 GVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEY 417 + E ++ + A KV IPL P++T+Y Sbjct: 582 --------YTPATYQLTEE------GTFRVVDEEAMEKVPWIPLDPLAPDLTQY 621 >6EIE-A nrPDB Length = 490 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 33/83 (39%), Gaps = 2/83 (2%) Query: 50 WWRRNVYERDDMEGLDASVLTHRLVLHYSGHEATFAD--PMVDNRITKKRYRLDHLLKEQ 107 W+ + + E ++ E A + +L F +V + YRLDH + Sbjct: 275 WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEAL 334 Query: 108 PEEVLKRLYRAMEVEEENLHALV 130 E K L A+E+ +++ + Sbjct: 335 QERKRKILDEAVELSQDHFKKYL 357 >1MG7-A nrPDB Length = 417 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 32/94 (34%), Gaps = 10/94 (10%) Query: 57 ERDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLY 116 M A R + E TF D +V +T V + Y Sbjct: 221 FTPQMFPSQAKAKLLRDAFNNEEDEDTFPDILVPAYMTAHS----------KNRVRQEDY 270 Query: 117 RAMEVEEENLHALVQAMMQAPERAGGAMTAAGVL 150 +EVE ++ AL + M + + G + G+L Sbjct: 271 TCLEVEFDSQVALEKLMNEHEQVEGFEVQQGGIL 304 >4QU2-A nrPDB Length = 318 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 53/174 (30%), Gaps = 22/174 (12%) Query: 244 FVRPGEDEYWHRYWVEERLKWWQEMGLSRENLVPYQQPPEELAHYAKATVDILYRFPHGL 303 FV P E R + L + L +Q + DI P Sbjct: 101 FVMPAER----RLPISHVLDVLEGRAQHPGVLYVQKQCSNLPTELPQLLSDIESHVPWAS 156 Query: 304 EELEGIANRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSA 363 E L + + +F LG + L S ++ P + + F+PY + Sbjct: 157 ESLGKMPDAVNFWLGDASAVTSLHKDHYENLYCVVSGEKHFLLHPPSDRPFIPYNL---- 212 Query: 364 GVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEY 417 + E ++ + A KV IPL P++T+Y Sbjct: 213 --------YTPATYQLTEE------GTFRVVDEEAMEKVPWIPLDPLAPDLTQY 252 >4BMQ-A nrPDB Length = 322 Score = 29.4 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 21/45 (46%), Gaps = 2/45 (4%) Query: 248 GEDEYWHRYWVEERLKWW--QEMGLSRENLVPYQQPPEELAHYAK 290 ED++ +W + ++W +E+ +S + Q EE Y + Sbjct: 9 KEDDFSLMFWKQNIAQFWTEEEIAVSSDKNTWVQLSKEEQIAYKR 53 >4P3N-A nrPDB Length = 415 Score = 29.4 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 1/39 (2%) Query: 207 RKLPFGIAQIGKAFRNEIT-PRNFIFRVREFEQMEIEYF 244 R+LP +A G RNE++ + RVR F+Q + F Sbjct: 120 RELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIF 158 >2A99-A nrPDB Length = 372 Score = 29.1 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 75/255 (29%), Gaps = 33/255 (12%) Query: 58 RDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYR 117 E L LT + H P V+ + R R+D L L Sbjct: 24 EPPAELLAERFLTPNELFFTRNHL---PVPAVE--PSSYRLRVDGPGGGTLSLSLAELRS 78 Query: 118 AMEVEEENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPV 177 E + + AG + + P G P D + G Sbjct: 79 RFPKHE---------VTATLQCAGNRRSEMSRVRPVKGLPWDIGAIST-----ARWGGAR 124 Query: 178 EDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVREFE 237 + L PE QG + LDA P+G + + ++P + E Sbjct: 125 LRDVLLHAGFPEELQGEWHVCFEGLDADPGGAPYGAS---IPYGRALSPAADVLLAYEMN 181 Query: 238 QMEIEYFVRPGEDEYWHRYWV-----EERLKWWQEMGLSRENLVPYQQPPEELAHYAKAT 292 E+ P + + R V +KW + + +S + + Q + Sbjct: 182 GTEL-----PRDHGFPVRVVVPGVVGARSVKWLRRVAVSPDESPSHWQQNDYKGFSPCVD 236 Query: 293 VD-ILYRFPHGLEEL 306 D + YR ++EL Sbjct: 237 WDTVDYRTAPAIQEL 251 >1SOX-A nrPDB Length = 466 Score = 28.7 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 75/255 (29%), Gaps = 33/255 (12%) Query: 58 RDDMEGLDASVLTHRLVLHYSGHEATFADPMVDNRITKKRYRLDHLLKEQPEEVLKRLYR 117 E L LT + H P V+ + R R+D L L Sbjct: 118 EPPAELLAERFLTPNELFFTRNHL---PVPAVE--PSSYRLRVDGPGGGTLSLSLAELRS 172 Query: 118 AMEVEEENLHALVQAMMQAPERAGGAMTAAGVLDPASGEPGDWTPPRYFNMMFKTYVGPV 177 E + + AG + + P G P D + G Sbjct: 173 RFPKHE---------VTATLQCAGNRRSEMSRVRPVKGLPWDIGAIST-----ARWGGAR 218 Query: 178 EDEASLAYLRPETAQGIFVNFKNVLDATSRKLPFGIAQIGKAFRNEITPRNFIFRVREFE 237 + L PE QG + LDA P+G + + ++P + E Sbjct: 219 LRDVLLHAGFPEELQGEWHVCFEGLDADPGGAPYGAS---IPYGRALSPAADVLLAYEMN 275 Query: 238 QMEIEYFVRPGEDEYWHRYWV-----EERLKWWQEMGLSRENLVPYQQPPEELAHYAKAT 292 E+ P + + R V +KW + + +S + + Q + Sbjct: 276 GTEL-----PRDHGFPVRVVVPGVVGARSVKWLRRVAVSPDESPSHWQQNDYKGFSPCVD 330 Query: 293 VD-ILYRFPHGLEEL 306 D + YR ++EL Sbjct: 331 WDTVDYRTAPAIQEL 345 >2WMN-A nrPDB Length = 428 Score = 28.3 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 17/37 (45%) Query: 394 KPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGL 430 L PI+VA+ + K E+ + + ++ L L Sbjct: 301 HTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQL 337 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.118 0.293 Lambda K H 0.267 0.0360 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,548,251 Number of Sequences: 36641 Number of extensions: 644614 Number of successful extensions: 1982 Number of sequences better than 10.0: 38 Number of HSP's better than 10.0 without gapping: 29 Number of HSP's successfully gapped in prelim test: 33 Number of HSP's that attempted gapping in prelim test: 1821 Number of HSP's gapped (non-prelim): 87 length of query: 506 length of database: 10,336,785 effective HSP length: 101 effective length of query: 405 effective length of database: 6,636,044 effective search space: 2687597820 effective search space used: 2687597820 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.3 bits)