BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P55263 (362 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2I6B-A nrPDB 715 0.0 5KB6-A nrPDB 697 0.0 3LOO-A nrPDB 365 e-101 4N08-A nrPDB 258 2e-69 3UQ9-A nrPDB 239 2e-63 2AA0-A nrPDB 169 2e-42 3UBO-A nrPDB 77 1e-14 4LC4-A nrPDB 77 1e-14 1RK2-A nrPDB 63 2e-10 2C4E-A nrPDB 58 7e-09 6ILS-A nrPDB 54 1e-07 5C40-A nrPDB 50 1e-06 3H49-A nrPDB 47 1e-05 2NWH-A nrPDB 46 2e-05 1V1S-A nrPDB 46 3e-05 3HJ6-A nrPDB 45 4e-05 3RY7-A nrPDB 44 1e-04 4X8F-A nrPDB 44 1e-04 5ZWY-A nrPDB 43 2e-04 1VM7-A nrPDB 43 2e-04 3GBU-A nrPDB 42 3e-04 2QHP-A nrPDB 42 3e-04 3KD6-A nrPDB 40 0.002 3LHX-A nrPDB 39 0.002 3PL2-A nrPDB 37 0.014 2QCV-A nrPDB 36 0.021 6CW5-A nrPDB 35 0.038 2VAR-A nrPDB 35 0.052 3JUL-A nrPDB 34 0.094 5EYN-A nrPDB 33 0.15 1TYY-A nrPDB 33 0.25 4E84-A nrPDB 33 0.28 4GM6-A nrPDB 32 0.41 4DU5-A nrPDB 32 0.45 4WJM-A nrPDB 31 0.69 3KTN-A nrPDB 31 1.0 3DIN-A nrPDB 30 1.3 5HFU-A nrPDB 29 4.0 4IDE-A nrPDB 28 4.6 3LJS-A nrPDB 28 5.4 5MM8-A nrPDB 28 5.6 6C9R-A nrPDB 28 6.2 2RCM-A nrPDB 28 6.4 1U83-A nrPDB 28 7.7 3AL6-A nrPDB 27 9.6 >2I6B-A nrPDB Length = 345 Score = 715 bits (1846), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/343 (99%), Positives = 343/343 (100%) Query: 20 ALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA 79 ++RENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA Sbjct: 3 SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA 62 Query: 80 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT 139 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT Sbjct: 63 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT 122 Query: 140 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKV 199 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKV Sbjct: 123 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKV 182 Query: 200 AHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIK 259 AHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIK Sbjct: 183 AHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIK 242 Query: 260 EIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF 319 EIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF Sbjct: 243 EIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF 302 Query: 320 VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 362 VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH Sbjct: 303 VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 345 >5KB6-A nrPDB Length = 363 Score = 697 bits (1799), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/360 (91%), Positives = 350/360 (97%) Query: 3 AAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH 62 AA +EPKPKKLKVEAPQAL EN+LFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH Sbjct: 4 AAADEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH 63 Query: 63 KELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAE 122 KELFDELVKKFKVEYHAGGSTQNS+KVAQW+IQ+PHKAATFFGCIGIDKFGEILKRKAA+ Sbjct: 64 KELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRKAAD 123 Query: 123 AHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVC 182 AHVDAHYYEQNEQPTGTCAACITG NRSL+ANLAAANCYKKEKHLDLE+NW+LVEKARV Sbjct: 124 AHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLERNWVLVEKARVY 183 Query: 183 YIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNET 242 YIAGFFLTVSPESVLKVA +A+ENNR+FTLNLSAPFISQF+KE+LM VMPYVDILFGNET Sbjct: 184 YIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFISQFFKEALMDVMPYVDILFGNET 243 Query: 243 EAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVL 302 EAATFAREQGFETKDIKEIAKK QALPK+NSKRQR VIFTQGRDDTI+A E++VTAF VL Sbjct: 244 EAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFTQGRDDTIVAAENDVTAFPVL 303 Query: 303 DQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 362 DQ+Q+EIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAAS+IIRRTGCTFPEKPDFH Sbjct: 304 DQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH 363 >3LOO-A nrPDB Length = 365 Score = 365 bits (938), Expect = e-101, Method: Compositional matrix adjust. Identities = 175/345 (50%), Positives = 242/345 (70%), Gaps = 4/345 (1%) Query: 19 QALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYH 78 ++LR+ +L G+GNPLLDISAVV+KD L+KY ++PN+ ILAE+KH ++ EL++K++ EY Sbjct: 19 ESLRDGMLVGLGNPLLDISAVVEKDLLNKYDMQPNNAILAEEKHMPMYQELIEKYQAEYI 78 Query: 79 AGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTG 138 AGGS QNS++VAQW++Q+P + A FFGC+G D++ IL+ +A V+ Y PTG Sbjct: 79 AGGSVQNSLRVAQWILQRP-RTAIFFGCVGQDEYARILEERATSNGVNVQYQRSATSPTG 137 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLK 198 TCA +TG RSL ANLAAAN + E HL + N ++ A+ Y++GFF TVS ES L Sbjct: 138 TCAVLVTGTQRSLCANLAAANDFTPE-HLRSDGNRAYLQGAQFFYVSGFFFTVSFESALS 196 Query: 199 VAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDI 258 VA A+ R+F +NLSAPF+ QFYK +L ++ PYVD+LFGNETEA A+E + T+D+ Sbjct: 197 VAKEAAATGRMFMMNLSAPFVPQFYKNNLEEIFPYVDVLFGNETEAIALAKEFNYGTEDL 256 Query: 259 KEIAKKTQALPKMNSKRQRIVIFTQGRDDTIM--ATESEVTAFAVLDQDQKEIIDTNGAG 316 +EI K+ ALPK N KR+RIVI TQG D ++ A V F V ++++DTNGAG Sbjct: 257 REIGKRIAALPKENGKRKRIVIITQGSDPVLLIEAGTDNVREFPVQKLAPEQMVDTNGAG 316 Query: 317 DAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDF 361 DAFVGGFL+QL+ + + CI+ G +AA II+R+GCTF +P F Sbjct: 317 DAFVGGFLAQLLQSRTVDVCIKCGIWAAREIIQRSGCTFEGEPSF 361 >4N08-A nrPDB Length = 348 Score = 258 bits (660), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 136/333 (40%), Positives = 193/333 (57%), Gaps = 4/333 (1%) Query: 31 NPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVA 90 NPLLD+SA V +FL KY L+ IL ++ K +FD++ K V Y GGS N +VA Sbjct: 16 NPLLDVSAHVSDEFLVKYGLERGTAILLSERQKGIFDDIEKMPNVRYVPGGSGLNVARVA 75 Query: 91 QWMIQQPHKA--ATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDN 148 QWM QQ +K T+ GCI D++G++LK A + + +G CA CITG Sbjct: 76 QWM-QQAYKGKFVTYVGCIADDRYGKVLKEAAEHEGIVMAVEHTTKAGSGACAVCITGKE 134 Query: 149 RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNR 208 R+L+A+L AAN E H+ ++++R+ Y +GF LTV VL+ A E + Sbjct: 135 RTLVADLGAANHLSSE-HMRSPAVVRAMDESRIFYFSGFTLTVDVNHVLQACRKAREVDG 193 Query: 209 IFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQAL 268 +F +NLSAPFI QF+ L +V+PY DI+ N EA FA ++T ++EIA++ + Sbjct: 194 LFMINLSAPFIMQFFSAQLGEVLPYTDIIVANRHEAKEFANMMKWDTDCVEEIARRAVSE 253 Query: 269 PKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLV 328 + R+V+FT+ + T++AT+ V V DQ ++ID NGAGDAF+GGFLS Sbjct: 254 VPYTGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVIDMNGAGDAFMGGFLSAYA 313 Query: 329 SDKPLTECIRAGHYAASIIIRRTGCTFPEKPDF 361 K L C GHY A +I+R GC+FPEKP F Sbjct: 314 VGKDLRRCCETGHYTAQEVIQRDGCSFPEKPSF 346 >3UQ9-A nrPDB Length = 372 Score = 239 bits (609), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 132/346 (38%), Positives = 204/346 (58%), Gaps = 8/346 (2%) Query: 21 LRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAG 80 L E +FGMGNPLLDI D KY+LK ++ +LAE+KH ++DE+ KK K+ Y AG Sbjct: 24 LSEGYVFGMGNPLLDIIVDADDFMYRKYNLKKDNIVLAEEKHMTIYDEIQKKKKLNYIAG 83 Query: 81 GSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQP--TG 138 G+T N++K+ QW+IQ+P ++ GCIG D G+ +K + + + + E+P TG Sbjct: 84 GATLNTVKMIQWIIQKPF-VCSYVGCIGADIQGKYIKNDCSALDLVTEF-QIAEEPLMTG 141 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLK 198 A ++ RS++ L AA C H++ W LVEKA+V YIAGF + E +LK Sbjct: 142 KVAVLVSEKLRSMVTYLGAA-CDLSLAHIEQPHVWSLVEKAQVYYIAGFVINTCYEGMLK 200 Query: 199 VAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDI 258 +A H+ EN ++F NLSAPF+SQF + + +++ Y +I+FGNE+EA + G + Sbjct: 201 IAKHSLENEKLFCFNLSAPFLSQFNTKEVDEMISYSNIVFGNESEAEAYGEVHGLLEDTV 260 Query: 259 KEIAKKTQALPKMNS-KRQRIVIFTQGRDDTIM--ATESEVTAFAVLDQDQKEIIDTNGA 315 A+ LP + KR+R+VI T+G++ + +++SE+ F V +IIDTNGA Sbjct: 261 HATARYIADLPFADGKKRKRLVIITRGKNPLLYTDSSDSEIHQFMVEQFKDDQIIDTNGA 320 Query: 316 GDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDF 361 GDAF GF++ + KP+ + A AA+ II R+G + + + Sbjct: 321 GDAFAAGFIADYIRGKPMITSLHAAVKAAAYIICRSGFSLGSRDSY 366 >2AA0-A nrPDB Length = 383 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 112/347 (32%), Positives = 173/347 (49%), Gaps = 28/347 (8%) Query: 26 LFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQN 85 +F +GNP+LD+ A V FLD++ LK D LA + ++ L +F GGS N Sbjct: 35 VFAIGNPILDLVAEVPSSFLDEFFLKRGDATLATPEQMRIYSTL-DQFNPTSLPGGSALN 93 Query: 86 SIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACIT 145 S++V Q ++++P A + G IG D G++LK + + + Q TG CA I Sbjct: 94 SVRVVQKLLRKPGSAG-YMGAIGDDPRGQVLKELCDKEGLATRFMVAPGQSTGVCAVLIN 152 Query: 146 GDNRSLIANLAAANCYKKEKHLDLEKNWM-LVEKARVCYIAGFFLTVSPESVLKVAHHAS 204 R+L +L A ++ L ++W A + Y + LT +P++ L+VA +A Sbjct: 153 EKERTLCTHLGACGSFR------LPEDWTTFASGALIFYATAYTLTATPKNALEVAGYAH 206 Query: 205 E-NNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFET--KDIKEI 261 N IFTLNLSAPF + YK+++ ++ + +ILFGNE E A A+ K Sbjct: 207 GIPNAIFTLNLSAPFCVELYKDAMQSLLLHTNILFGNEEEFAHLAKVHNLVAAEKTALST 266 Query: 262 AKKTQAL-----------PKMNSKRQRIVIFTQGRDDTIMATESE-----VTAFAVLDQD 305 A K A+ N+ ++V+ T+G + I A ++ V V Sbjct: 267 ANKEHAVEVCTGALRLLTAGQNTSATKLVVMTRGHNPVIAAEQTADGTVVVHEVGVPVVA 326 Query: 306 QKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 ++I+DTNGAGDAFVGGFL L K + +CI G+ A +I+ G Sbjct: 327 AEKIVDTNGAGDAFVGGFLYALSQGKTVKQCIMCGNACAQDVIQHVG 373 >3UBO-A nrPDB Length = 354 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 87/337 (25%), Positives = 148/337 (43%), Gaps = 45/337 (13%) Query: 29 MGNPLLDISAVVDKDFLDKYSL-KPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSI 87 +GN ++DI A D FL++ + K ++ D+ + L+ + + +GGS N+ Sbjct: 11 IGNAIVDIIARCDDSFLEENGIIKGAMNLINADRAELLYSRMGPAVEA---SGGSAGNT- 66 Query: 88 KVAQWMIQQPHKAATFFGCIGIDKFGEILKR--KAAEAH-----VDAHYYEQNEQPTGTC 140 A + +AA +FG + D+ GEI +A H +D H PT Sbjct: 67 --AAGVASLGGRAA-YFGKVADDQLGEIFTHDIRAQGVHFQTKPLDGH------PPTARS 117 Query: 141 AACITGDN-RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLT--VSPESVL 197 +T D RS+ L A E D+E + +V +++V Y G+ + +++ Sbjct: 118 MIFVTEDGERSMNTYLGACVELGPE---DVEDD--VVAQSKVTYFEGYLWDPPRAKDAIR 172 Query: 198 KVAHHASENNRIFTLNLSAPFISQFYKESLMKVM--PYVDILFGNETEAATFAREQGFET 255 + A A + R + LS F Y+ +++M VDI+F N EA +ET Sbjct: 173 EAARIAHAHGRETAMTLSDSFCVHRYRSEFLELMRSGTVDIVFANRQEALAL-----YET 227 Query: 256 KDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGA 315 +D + L + K + + +G + E +VL+Q ++DT GA Sbjct: 228 EDFD----RALELLARDCKLAAVTLSEEG-SVVVRGAERVRVGASVLEQ----VVDTTGA 278 Query: 316 GDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 GD + GFL S + L EC + G+ AA I+I + G Sbjct: 279 GDLYAAGFLFGYTSGRSLEECSKLGNLAAGIVIGQIG 315 >4LC4-A nrPDB Length = 352 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 86/335 (25%), Positives = 147/335 (43%), Gaps = 41/335 (12%) Query: 29 MGNPLLDISAVVDKDFL-DKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSI 87 +GN ++DI + + FL D K ++ ++ + L+ + + +GGS N+ Sbjct: 31 VGNAIVDIISRCNDQFLIDNQITKAAMNLIDAERAELLYSRMGPALEA---SGGSAGNT- 86 Query: 88 KVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ---PTGTCAACI 144 A + KAA +FG + D+ G+I V HY + + PT + Sbjct: 87 --AAGVANLGGKAA-YFGNVAADQLGDIFTHDIRAQGV--HYQTKPKGAFPPTARSMIFV 141 Query: 145 TGDN-RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLT--VSPESVLKVAH 201 T D RS+ L A E D+E + +V A+V Y G+ + E++L A Sbjct: 142 TEDGERSMNTYLGACVELGPE---DVEAD--VVADAKVTYFEGYLWDPPRAKEAILDCAR 196 Query: 202 HASENNRIFTLNLSAPFISQFYKESLMKVMPY--VDILFGNETEAATFAREQGFETKDIK 259 A ++ R ++ LS F Y+ + +M VDI+F N EA + ++T D + Sbjct: 197 IAHQHGREMSMTLSDSFCVDRYRGEFLDLMRSGKVDIVFANRQEALSL-----YQTDDFE 251 Query: 260 EIAKKTQALPKMN--SKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGD 317 E + A K+ + + + +GR+ V A + +E++DT GAGD Sbjct: 252 EALNRIAADCKIAAVTMSENGAVILKGRE------RYYVNAIRI-----REVVDTTGAGD 300 Query: 318 AFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 F GFL + L +C + G AA I+I++ G Sbjct: 301 LFASGFLYGYTQGRSLEDCGKLGCLAAGIVIQQIG 335 >1RK2-A nrPDB Length = 309 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 26/260 (10%) Query: 103 FFGCIGIDKFGEILKRKAAEAHVDAHYYEQ-NEQPTGTCAACITGDNRSLIANLAAANCY 161 F C G D GE ++++ A ++D + TG + G+ ++I A AN Sbjct: 60 FIACTGDDSIGESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAA 119 Query: 162 KKEKHLDLEKNWMLVEKARVCYIAGFFLTV-SP-ESVLKVAHHASENNRIFTLNLSAPFI 219 L + ++ R+ + + + SP ESV+ A A +N I LN AP Sbjct: 120 -------LSPALVEAQRERIANASALLMQLESPLESVMAAAKIAHQNKTIVALN-PAP-- 169 Query: 220 SQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIV 279 +E +++ VDI+ NETEA G ++ ++ AK Q L + + I Sbjct: 170 ---ARELPDELLALVDIITPNETEAEKLT---GIRVENDEDAAKAAQVLHEKGIRTVLIT 223 Query: 280 IFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRA 339 + ++G ++ V F V + +DT AGD F G ++ L+ +KPL E IR Sbjct: 224 LGSRGVWASVNGEGQRVPGFRV------QAVDTIAAGDTFNGALITALLEEKPLPEAIRF 277 Query: 340 GHYAASIIIRRTGCTFPEKP 359 H AA+I + R G P P Sbjct: 278 AHAAAAIAVTRKGAQ-PSVP 296 >2C4E-A nrPDB Length = 302 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 63/281 (22%), Positives = 110/281 (39%), Gaps = 39/281 (13%) Query: 76 EYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKR--KAAEAHVDAHYYEQN 133 +Y+ G + ++ + + + + C+G D +R K + ++ YY + Sbjct: 39 KYYGGAAANTAVGIKKLGVN-----SELLSCVGYDFKNSGYERYLKNLDINISKLYYSEE 93 Query: 134 EQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSP 193 E+ +N+ AA YK+ + + +IA T P Sbjct: 94 EETPKAWIFTDKDNNQITFFLWGAAKHYKELNPPNF--------NTEIVHIA----TGDP 141 Query: 194 ESVLKVAHHASENNRI-FTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQG 252 E LK A A NN + F P Q+ KE L++++ + + LF N+ E + Sbjct: 142 EFNLKCAKKAYGNNLVSFDPGQDLP---QYSKEMLLEIIEHTNFLFMNKHEFERASNLLN 198 Query: 253 FETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDT 312 FE D E R +I T+G +++ T+ + + + +ID Sbjct: 199 FEIDDYLE--------------RVDALIVTKGSKGSVIYTKDKKIEIPCIKAGK--VIDP 242 Query: 313 NGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGC 353 GAGD++ GFLS V L +C G AS ++ GC Sbjct: 243 TGAGDSYRAGFLSAYVKGYDLEKCGLIGAATASFVVEAKGC 283 >6ILS-A nrPDB Length = 313 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 109/275 (39%), Gaps = 48/275 (17%) Query: 103 FFGCIGIDKFG----EILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAA 158 F G +G D G E L H+D + N +PTG + D ++ I + A Sbjct: 58 FVGRLGEDAHGKLIAEALGDDGCGVHLD-YVRSVNNEPTGHAVVMLQSDGQNSIIIVGGA 116 Query: 159 NCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESV-LKVAHHASENNRIFTLNLSA- 216 N K + + + +V A + + P+S+ ++VA + L++ Sbjct: 117 N-MKAWPEIMSDDDLEIVRNAGIVLLQREI----PDSINIQVAKAVKKAGVPVILDVGGM 171 Query: 217 --PFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKT--------- 265 P ++ +DIL NETE +R G T+ ++I++ Sbjct: 172 DTPIPNELLDS--------IDILSPNETE---LSRLTGMPTETFEQISQAVAKCHKLGVK 220 Query: 266 QALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLS 325 Q L K+ SK +F QG +S + A +++DT GAGD F F Sbjct: 221 QVLVKLGSKGS--ALFIQGEKPI---QQSIIPA--------AQVVDTTGAGDTFTAAFAV 267 Query: 326 QLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD 360 +V K EC+R AAS+ ++ G P PD Sbjct: 268 AMVEGKSHEECLRFAAAAASLCVQVKG-AIPSMPD 301 >5C40-A nrPDB Length = 330 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/264 (22%), Positives = 110/264 (41%), Gaps = 30/264 (11%) Query: 107 IGIDKFGEILKRKAAEAHVDAHY-YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEK 165 +G D FG + + + Y+ + TGT + + + +++I +A AN + Sbjct: 75 VGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTE 134 Query: 166 HLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFIS----Q 221 L N + K VC L ++P + L+ A + + TL AP I+ Q Sbjct: 135 DLRAAANVISRAKVMVCQ-----LEITPATSLEALTMARRSG-VKTLFNPAPAIADLDPQ 188 Query: 222 FYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIF 281 FY S D+ NE+EA G + + L K + ++VI Sbjct: 189 FYTLS--------DVFCCNESEAEILT---GLTVGSAADAGEAALVLLK---RGCQVVII 234 Query: 282 TQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVG--GFLSQLVSDKPLTECIRA 339 T G + ++ +++E + + K + DT GAGD+FVG F + L + + Sbjct: 235 TLGAEGCVVLSQTEPEPKHIPTEKVKAV-DTTGAGDSFVGALAFYLAYYPNLSLEDMLNR 293 Query: 340 GHYAASIIIRRTGC--TFPEKPDF 361 ++ A++ ++ G ++P K D Sbjct: 294 SNFIAAVSVQAAGTQSSYPYKKDL 317 >3H49-A nrPDB Length = 325 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 71/300 (23%), Positives = 128/300 (42%), Gaps = 31/300 (10%) Query: 62 HKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAA 121 K +FD V + +E A + ++I A + + H+ A IG D G+ + Sbjct: 24 SKNIFD--VDSYPLERIAMTTGGDAINEATIISRLGHRTA-LMSRIGKDAAGQFILDHCR 80 Query: 122 EAHVDAHYYEQNEQ-PTGTCAACITGDN-RSLIANLAAANCYKKEKHLDLEKNWMLVEKA 179 + ++D +Q+ T +T D R+ + N N + ++D + ++ +A Sbjct: 81 KENIDIQSLKQDVSIDTSINVGLVTEDGERTFVTN---RNGSLWKLNID-DVDFARFSQA 136 Query: 180 RVCYIAGFFLT--VSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDIL 237 ++ +A F + + +++ ++ A I ++ P +++ + + + + YVD L Sbjct: 137 KLLSLASIFNSPLLDGKALTEIFTQAKARQMIICADMIKPRLNETL-DDICEALSYVDYL 195 Query: 238 FGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA---TES 294 F N EA G ET D EIA A + V+ G+D + Sbjct: 196 FPNFAEAKLLT---GKETLD--EIADCFLACG------VKTVVIKTGKDGCFIKRGDMTM 244 Query: 295 EVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCT 354 +V A A + IDT GAGD F GF++ L+ K L EC R + A+I + G T Sbjct: 245 KVPAVAGITA-----IDTIGAGDNFASGFIAALLEGKNLRECARFANATAAISVLSVGAT 299 >2NWH-A nrPDB Length = 317 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 69/256 (26%), Positives = 101/256 (39%), Gaps = 35/256 (13%) Query: 108 GIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHL 167 G D GE++ A +A V+ + ++ T + A + D +IA LA + YK Sbjct: 63 GGDVTGEVVAEAARQAGVEDTPFTFLDRRTPSYTAILERDGNLVIA-LADMDLYKL---- 117 Query: 168 DLEKNWMLVEKARVCYIAGFFLTVS---PESVLKVAHHASENNRIFTLNLSAPFISQFYK 224 + V R IA FL PE L + R L+A IS Sbjct: 118 -FTPRRLKVRAVREAIIASDFLLCDANLPEDTLTALGLIA---RACEKPLAAIAISPAKA 173 Query: 225 ESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQG 284 L + +DILF NE EA E +D I +K + T+G Sbjct: 174 VKLKAALGDIDILFMNEAEARALTGETAENVRDWPNILRKAGLSGG---------VVTRG 224 Query: 285 RDDTIMATESEVTAF-----AVLDQDQ-KEIIDTNGAGDAFVGGFLSQLVSDKPLTECIR 338 SEV AF A+L +E+ D GAGDA G+L+ + K + E +R Sbjct: 225 --------ASEVVAFNGTEKAILHPPLIREVKDVTGAGDAMASGYLAAIAEGKTIREALR 276 Query: 339 AGHYAASIIIRRTGCT 354 G AA+I ++ + T Sbjct: 277 QGAAAAAITVQSSFAT 292 >1V1S-A nrPDB Length = 309 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 65/281 (23%), Positives = 110/281 (39%), Gaps = 41/281 (14%) Query: 69 LVKKFKVEYHAGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDA 127 L K +E + GG+ N ++ +A+ ++ F G +G D+ G +++ + VD Sbjct: 22 LRGKRLLEVYVGGAEVNVAVALARLGVK-----VGFVGRVGEDELGAMVEERLRAEGVDL 76 Query: 128 HYYEQNEQPTGTCAA--CITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIA 185 ++ + TG G R +A D + +E R +++ Sbjct: 77 THFRRAPGFTGLYLREYLPLGQGRVFYYRKGSAGSALAPGAFDPD----YLEGVRFLHLS 132 Query: 186 GFFLTVSPES-VLKVAHHASENNRIFTLNLSAPFISQFY-----KESLMKVMPYVDILFG 239 G +SPE+ + R ++L + + + L + +P VD+LF Sbjct: 133 GITPALSPEARAFSLWAMEEAKRRGVRVSLDVNYRQTLWSPEEARGFLERALPGVDLLFL 192 Query: 240 NETEA-ATFAR-EQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVT 297 +E EA F R E+ E+ K A + F GR E + Sbjct: 193 SEEEAELLFGRVEEALRALSAPEVVLKRGA--------KGAWAFVDGR-------RVEGS 237 Query: 298 AFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIR 338 AFAV E +D GAGDAF G+L+ V P+ E +R Sbjct: 238 AFAV------EAVDPVGAGDAFAAGYLAGAVWGLPVEERLR 272 >3HJ6-A nrPDB Length = 327 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 74/346 (21%), Positives = 128/346 (36%), Gaps = 47/346 (13%) Query: 23 ENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGS 82 E ++ G+ N +S K LD SL +IL + E + L + + H GGS Sbjct: 4 EGVIVGILNKNFSLS----KGDLDVVSLG---EILVDMISTEEVNSLSQSREYTRHFGGS 56 Query: 83 TQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAA 142 N I V + + K +G D FG L + +Q+++ T Sbjct: 57 PAN-IAVN---LSRLGKKVALISRLGADAFGNYLLDVLKGEQIITDGIQQDKERRTTIVY 112 Query: 143 CITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSP--ESVLKVA 200 A+ Y +E + E L+++++V +++ F L+ P ++ +K Sbjct: 113 VSKSTRTPDWLPYREADMYLQEDDIIFE----LIKRSKVFHLSTFILSRKPARDTAIKAF 168 Query: 201 HHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKE 260 ++A E +I + Y +L+ + A E +K Sbjct: 169 NYAREQGKIVCFDPC-----------------YRKVLWPEGDDGAGVVEEIISRADFVKP 211 Query: 261 IAKKTQAL-----PKMNSKRQ-----RIVIFTQGRDDTIMATESEVTAFAVLDQDQKEII 310 + L P+ KR + VI T G + I + E+ +D + Sbjct: 212 SLDDARHLFGPDSPENYVKRYLELGVKAVILTLGEEGVIASDGEEIIRIPAFSEDA---V 268 Query: 311 DTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFP 356 D GAGDAF GF+ L+ + I+ G+ A+ IR G P Sbjct: 269 DVTGAGDAFWSGFICGLLDGYTVKRSIKLGNGVAAFKIRGVGALSP 314 >3RY7-A nrPDB Length = 304 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 69/306 (22%), Positives = 125/306 (40%), Gaps = 34/306 (11%) Query: 54 DQILAEDKHKELFDEL-VKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKF 112 DQ L +++ + + L V++ + + G +I A+ TF IG D Sbjct: 14 DQFLTVERYAQPGETLHVEEAQKAFGGGKGANQAIATARM-----QADTTFITKIGTDGV 68 Query: 113 GEILKRKAAEAHVDAHY-YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEK 171 + + AH+D Y + E TG + + ++ I AN + + K Sbjct: 69 ADFILEDFKVAHIDTSYIIKTAEAKTGQAFITVNAEGQNTIYVYGGANMTMTPEDVINAK 128 Query: 172 NWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVM 231 + ++ V L V +++ A + LN AP K +++ Sbjct: 129 DAIINADFVVAQ-----LEVPIPAIISAFEIAKAHGVTTVLN-PAP-----AKALPNELL 177 Query: 232 PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA 291 +DI+ NETEA + + + +K+ A S + V+ T G+ T A Sbjct: 178 SLIDIIVPNETEAELLSGIKVTNEQSMKDNAN------YFLSIGIKTVLITLGKQGTYFA 231 Query: 292 TESE---VTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL-VSDKPLTECIRAGHYAASII 347 T+++ + A+ V IDT AGD F+G F+S+L S L + I G+ A+S+ Sbjct: 232 TKNQSQHIEAYKV------NAIDTTAAGDTFIGAFVSRLNKSQDNLADAIDFGNKASSLT 285 Query: 348 IRRTGC 353 +++ G Sbjct: 286 VQKHGA 291 >4X8F-A nrPDB Length = 309 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 99/254 (38%), Gaps = 27/254 (10%) Query: 103 FFGCIGIDKFGEILKRKAAEAHVD-AHYYEQNEQPTGTCAACITGDNRSLIANLAAANCY 161 F C+G D FG ++ ++ A Q PTG ++ + I A AN Sbjct: 60 FIACVGDDSFGINIRESFKLDGINTAGVKLQPNCPTGIAMIQVSDSGENSICISAEANA- 118 Query: 162 KKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQ 221 K +E + + AR + L + +LK A A LN P ++ Sbjct: 119 -KLTAAAIEPDLAAIRDARYLLMQ---LETPLDGILKAAQEAKTAKTNVILN---PAPAR 171 Query: 222 FYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIF 281 + L+K VD++ NETEA G D + QA ++ K IVI Sbjct: 172 ELPDELLKC---VDLITPNETEAEVLT---GITVYDD---SSAQQAADALHCKGIEIVII 222 Query: 282 TQGRDDTIMATESE---VTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIR 338 T G ++ + F V + DT AGD F G ++ L+ + PL I+ Sbjct: 223 TLGSKGVWLSQNGRGQRIPGFVV------KATDTTAAGDTFNGALVTGLLQEMPLESAIK 276 Query: 339 AGHYAASIIIRRTG 352 H AA+I + R G Sbjct: 277 FAHAAAAISVTRFG 290 >5ZWY-A nrPDB Length = 349 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 63/144 (43%), Gaps = 8/144 (5%) Query: 209 IFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQAL 268 ++T+ SAP E + +PYV + NE EA G + D + +AL Sbjct: 198 VYTVFNSAPAPKPAEVEQIKPFLPYVSLFCPNEVEATLIT---GVKVTDTESAFSAIKAL 254 Query: 269 PKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLV 328 ++ R V+ T G ++ +E+ V + K + DT GAGD FVG + + Sbjct: 255 QQLGV---RDVVITLGAAGFVL-SENGAEPVHVTGKHVKAV-DTTGAGDCFVGSMVYFMS 309 Query: 329 SDKPLTECIRAGHYAASIIIRRTG 352 + L E + + A+I + R G Sbjct: 310 RGRNLLEACKRANECAAISVTRKG 333 >1VM7-A nrPDB Length = 311 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 64/279 (22%), Positives = 110/279 (39%), Gaps = 35/279 (12%) Query: 77 YHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQP 136 + G ++ VA+ K F CIG D + ++L + + Y + P Sbjct: 49 FPGGKGANQAVTVAKI----GEKGCRFVTCIGNDDYSDLLIENYEKLGITG--YIRVSLP 102 Query: 137 TGTCAACI--TGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPE 194 TG + TG NR +I AN K++ +D W + ++ + + + E Sbjct: 103 TGRAFIEVDKTGQNRIII--FPGANAELKKELID----WNTLSESDILLLQN---EIPFE 153 Query: 195 SVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFE 254 + L+ A R + + P +Q E + + Y+D L NE E +++ E Sbjct: 154 TTLECAK------RFNGIVIFDPAPAQGINEEIFQ---YLDYLTPNEKEIEALSKDFFGE 204 Query: 255 TKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNG 314 +++ A+K L N VI G ++ ++E F + + +DT Sbjct: 205 FLTVEKAAEKFLELGVKN------VIVKLGDKGVLLVNKNEKKHFPTF---KVKAVDTTA 255 Query: 315 AGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGC 353 AGD F G F L K E + G AA+I + R G Sbjct: 256 AGDVFNGAFAVALSEGKNPEEAVIFGTAAAAISVTRLGA 294 >3GBU-A nrPDB Length = 313 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 61/261 (23%), Positives = 118/261 (45%), Gaps = 47/261 (18%) Query: 76 EYHAGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNE 134 E H GG+ N ++ V++ ++ ++ +G D FGE L + ++ +VD ++E Sbjct: 29 EKHPGGAPANVAVGVSRLGVK-----SSLISKVGNDPFGEYLIEELSKENVDTRGIVKDE 83 Query: 135 QP-TGTCAACITGDNRSLIANLAAANCYKKEKHLDL---EKNWMLVEKARVCYIAGFFLT 190 + TG + G + S + Y + ++ + NW +VE+A++ L Sbjct: 84 KKHTGIVFVQLKGASPSFL-------LYDDVAYFNMTLNDINWDIVEEAKIVNFGSVILA 136 Query: 191 VSP--ESVLKVAHHASENNRI-FTLNLSAPFISQFYKESLMKVM----PYVDILFGNETE 243 +P E+V+KV ++ I F +NL + + +E ++KV+ DI+ +E E Sbjct: 137 RNPSRETVMKVIKKIKGSSLIAFDVNLRLD-LWRGQEEEMIKVLEESIKLADIVKASEEE 195 Query: 244 AATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLD 303 + QG E K A+ + K R++ +++T++ +V ++ V Sbjct: 196 V-LYLENQGVEVK-----GSMLTAIT-LGPKGFRLI-----KNETVV----DVPSYNV-- 237 Query: 304 QDQKEIIDTNGAGDAFVGGFL 324 +DT GAGDAF+ L Sbjct: 238 ----NPLDTTGAGDAFMAALL 254 >2QHP-A nrPDB Length = 296 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 73/152 (48%), Gaps = 12/152 (7%) Query: 208 RIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQA 267 +IF +NL F + KE L + +IL N+ E T +R G+ D+++ K Sbjct: 149 KIFDINLRQDF---YTKEVLRESFKRCNILKINDEELVTISRMFGYPGIDLQD--KCWIL 203 Query: 268 LPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL 327 L K N K ++I T G + + + T V +F + + + DT GAGD+F F + + Sbjct: 204 LAKYNLK---MLILTCGINGSYVFTPG-VVSFQ--ETPKVPVADTVGAGDSFTAAFCASI 257 Query: 328 VSDKPLTECIRAGHYAASIIIRRTGCTFPEKP 359 ++ K + E + ++ + ++G PE P Sbjct: 258 LNGKSVPEAHKLAVEVSAYVCTQSG-AMPELP 288 >3KD6-A nrPDB Length = 313 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 71/171 (41%), Gaps = 28/171 (16%) Query: 191 VSPESVLKVAHHASENNRIF--TLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFA 248 + PE LKV + + T+N F + E L KV+ VD+ N++EA + Sbjct: 128 IDPELQLKVLDQIDDPKLVVCDTMN----FWIEGKPEELKKVLARVDVFIVNDSEARLLS 183 Query: 249 REQGF--ETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQ 306 + + I+E+ KT +I +G ++ T++ + FA Sbjct: 184 GDPNLVKTARIIREMGPKT-------------LIIKKGEHGALLFTDNGI--FAAPAFPL 228 Query: 307 KEIIDTNGAGDAFVGGFLSQL-----VSDKPLTECIRAGHYAASIIIRRTG 352 + I D GAGD F GGF+ L S+ + + + G AS + + G Sbjct: 229 ESIYDPTGAGDTFAGGFIGHLARCGNTSEAEMRKAVLYGSAMASFCVEQFG 279 >3LHX-A nrPDB Length = 319 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 40/81 (49%), Gaps = 1/81 (1%) Query: 279 VIFTQGRDDTIMATESE-VTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECI 337 V+ +G D +++ E + + ++++IDT AGD+F G+L+ ++ Sbjct: 227 VVVKRGADSCLVSIAGEALVDVPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAENAA 286 Query: 338 RAGHYAASIIIRRTGCTFPEK 358 + GH AS +I+ G P + Sbjct: 287 KRGHLTASTVIQYRGAIIPRE 307 >3PL2-A nrPDB Length = 319 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 29/118 (24%) Query: 240 NETEAATFAR---EQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEV 296 ETE R E+G E +K+ K A+ K D+T+ EV Sbjct: 211 GETEPERAGRALLERGVELAIVKQGPKGVMAMTK---------------DETV-----EV 250 Query: 297 TAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCT 354 F V ++I+ GAGDAF G L+S+ PL + +R + A +++ R C+ Sbjct: 251 PPFFV------DVINGLGAGDAFGGALCHGLLSEWPLEKVLRFANTAGALVASRLECS 302 >2QCV-A nrPDB Length = 332 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 43/192 (22%), Positives = 87/192 (45%), Gaps = 26/192 (13%) Query: 170 EKNWMLVEKARVCYIAGFFLTVSP--ESVLKVAHHASENNR--IFTLNLSAPFISQFYKE 225 E N + ++++ ++G L+ SP E+VLK A N+ +F L+ P+ + +E Sbjct: 130 EVNEAYIRRSKLLLVSGTALSKSPSREAVLKAIRLAKRNDVKVVFELDYR-PYSWETPEE 188 Query: 226 SLMK---VMPYVDILFGNETEAATFAR--EQGFETKDIKEIAKKTQALPKMNSKRQRIVI 280 + + V DI+ G E E+G + I+ + K + L ++ Sbjct: 189 TAVYYSLVAEQSDIVIGTREEFDVLENRTEKGDNDETIRYLFKHSPEL----------IV 238 Query: 281 FTQGRDDTIMATES--EVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIR 338 G + + T++ +A + +++ T GAGD++ FL L+S K + ++ Sbjct: 239 IKHGVEGSFAYTKAGEAYRGYAY----KTKVLKTFGAGDSYASAFLYALISGKGIETALK 294 Query: 339 AGHYAASIIIRR 350 G +ASI++ + Sbjct: 295 YGSASASIVVSK 306 >6CW5-A nrPDB Length = 332 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 25/47 (53%) Query: 306 QKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 Q + DT GAGD F G F++ L+S K L + ++ A I + G Sbjct: 270 QNPVKDTTGAGDCFAGYFVAGLMSGKSLQDALKTCLVACGICVENEG 316 >2VAR-A nrPDB Length = 313 Score = 35.0 bits (79), Expect = 0.052, Method: Compositional matrix adjust. Identities = 62/285 (21%), Positives = 115/285 (40%), Gaps = 28/285 (9%) Query: 76 EYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGE-ILKRKAAEAHVDAHYYEQNE 134 E H GS N + + H + + +G D+FG+ I++ A+ +H NE Sbjct: 29 EKHVAGSELNFC----IAVVRNHLSCSLIARVGNDEFGKNIIEYSRAQGIDTSHIKVDNE 84 Query: 135 QPTGT--CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVS 192 TG +S + + + D+ +N+ V +R+ + G L +S Sbjct: 85 SFTGIYFIQRGYPIPMKSELVYYRKGSAGSRLSPEDINENY--VRNSRLVHSTGITLAIS 142 Query: 193 ---PESVLKVAHHASENNRIFTLNLSAPFISQF--YKESLMKVMPYVDILFGNETEAATF 247 E+V+K A +R N+ S KE+++ ++ DI E Sbjct: 143 DNAKEAVIKAFELAK--SRSLDTNIRPKLWSSLEKAKETILSILKKYDI------EVLIT 194 Query: 248 AREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQK 307 + +TK + ++ +A K +++++ G I A + V AF D + Sbjct: 195 DPD---DTKILLDVTDPDEAYRKYKELGVKVLLYKLGSKGAI-AYKDNVKAFK--DAYKV 248 Query: 308 EIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 + D GAGDA G F+S + K + + G A++++I G Sbjct: 249 PVEDPTGAGDAMAGTFVSLYLQGKDIEYSLAHGIAASTLVITVRG 293 >3JUL-A nrPDB Length = 320 Score = 34.3 bits (77), Expect = 0.094, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 28/43 (65%), Gaps = 1/43 (2%) Query: 314 GAGDAFVGGFLSQLVSDKPLTECIR-AGHYAASIIIRRTGCTF 355 GAGD FVG F++ L + P+TE ++ A +AS ++++ +F Sbjct: 250 GAGDVFVGAFIAGLAMNMPITETLKVATGCSASKVMQQDSSSF 292 >5EYN-A nrPDB Length = 323 Score = 33.5 bits (75), Expect = 0.15, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 3/50 (6%) Query: 278 IVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL 327 +V+ T G ++AT + ++ + IDT GAGDAFVGG L +L Sbjct: 230 LVVVTLGAKGALVATPNSQQ---IVSGKAVKPIDTTGAGDAFVGGLLYRL 276 >1TYY-A nrPDB Length = 339 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 13/20 (65%), Positives = 16/20 (80%) Query: 308 EIIDTNGAGDAFVGGFLSQL 327 +++DT GAGDAFVGG L L Sbjct: 263 DVVDTTGAGDAFVGGLLFTL 282 >4E84-A nrPDB Length = 352 Score = 32.7 bits (73), Expect = 0.28, Method: Compositional matrix adjust. Identities = 13/47 (27%), Positives = 25/47 (53%) Query: 307 KEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGC 353 +E+ D +GAGD + + L + PL + + + AA I++ + G Sbjct: 296 REVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANRAAGIVVGKLGT 342 >4GM6-A nrPDB Length = 351 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 43/202 (21%), Positives = 83/202 (41%), Gaps = 25/202 (12%) Query: 159 NCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSP---ESVLKVAHHASENN-RI-FTLN 213 + + + K +D + + L++ RV +++G + +S E V+K+ A N +I F +N Sbjct: 132 SSFARHKSMDWDLS-ELLKGIRVLHVSGITIALSTFWLEMVVKIIREAKRNGIKISFDMN 190 Query: 214 LSAPFIS-QFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMN 272 A + K + +++P VD + +A F FE ++ T M+ Sbjct: 191 YRAKLWELEAAKRAYQQLLPLVDYCSAGQMDAVAF-----FEIS-----SETTDYYQAMH 240 Query: 273 SKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKE--------IIDTNGAGDAFVGGFL 324 K I +F + I A+ + + E I+D G GDA+ L Sbjct: 241 DKYPNIELFYATKRTVISASHHLLQGHLWTQGECWESEEYAIYPIVDRVGGGDAYTAAVL 300 Query: 325 SQLVSDKPLTECIRAGHYAASI 346 ++S+ E ++ AA + Sbjct: 301 HGILSEWRPDETVKFATAAAGL 322 >4DU5-A nrPDB Length = 336 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 18/62 (29%), Positives = 29/62 (46%), Gaps = 5/62 (8%) Query: 291 ATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRR 350 A V F V E++DT GAGD F G +S L+ + E ++ G + + ++ Sbjct: 264 AGSGRVAGFPV-----AEVVDTVGAGDGFAVGVISALLDGLGVPEAVKRGAWIGARAVQV 318 Query: 351 TG 352 G Sbjct: 319 LG 320 >4WJM-A nrPDB Length = 312 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 71/299 (23%), Positives = 119/299 (39%), Gaps = 46/299 (15%) Query: 79 AGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTG 138 AGGS N+ +A + P FF I D FG++L+ A ++VD + + +PT Sbjct: 34 AGGSVFNT-AIALGRLGVP---TGFFSGISSDFFGDVLRDTLARSNVDYSFAAISNRPT- 88 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWM-LVEKARVCYIAGFFLTVSPE--S 195 T A D ++ A + L +N M V++ + G +S S Sbjct: 89 TLAFVRLVDGQARYAFYDENTAGRM-----LSRNDMPYVDETISAMLFGCISLISEPCGS 143 Query: 196 VLKVAHHASENNRIFTL--NLSAPFIS--QFYKESLMKVMPYVDILFGNETEAATFAREQ 251 V + NR+ L N+ A I+ + + + +++ DI+ ++ + F E+ Sbjct: 144 VYETLLAREAPNRVMFLDPNIRANLITVRKTHLTRMKRMIALADIVKLSDEDLDWFG-EK 202 Query: 252 GFETKDIKEIAKKTQAL-PKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEII 310 G EIA + L PK+ V+ T+G + T + D ++ Sbjct: 203 GSH----DEIAAEWLKLGPKL-------VVITKGAHGAVAYTNHATVPVPGVKVD---VV 248 Query: 311 DTNGAGDAFVGGFLSQLVSDKPLTE-------------CIRAGHYAASIIIRRTGCTFP 356 DT GAGD G L+ L S LT+ + G AA++ + R G P Sbjct: 249 DTVGAGDTVNAGILASLHSQGLLTKDALANLSEDQIHSAVALGVRAAAVTVSRAGANPP 307 >3KTN-A nrPDB Length = 346 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 36/174 (20%), Positives = 75/174 (43%), Gaps = 19/174 (10%) Query: 165 KHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAH--HASENNRIFTLN----LSAPF 218 K D E V+ +C I+ + ++ L +A HA + F N L+ Sbjct: 119 KDYDFEAFLAEVDMVHICGISLSLTEKTRDAALILAQKAHAYQKKVCFDFNYRPSLNTAN 178 Query: 219 ISQFYKESLMKVMPYVDILFGNETEAATFAREQGF-ETKDIKEIAKKTQALPKMNSKRQR 277 + F ++ +++PY DI+FG+ + GF +D++ A++T+ + + S Q Sbjct: 179 SALFMRQQYERILPYCDIVFGSRRDLVELL---GFIPREDLEGEAQETELIQRFMS--QY 233 Query: 278 IVIFTQGRDDTIMATESEVTAFAVLDQDQKEI-------IDTNGAGDAFVGGFL 324 + + G + ++ ++ + + ++ +D GAGDA+ G L Sbjct: 234 NLEWFAGTTRSHSQNQNYLSGYLYTQNEYQQSEKRPLLNLDRIGAGDAYAAGIL 287 >3DIN-A nrPDB Length = 871 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 31/112 (27%), Positives = 52/112 (46%), Gaps = 18/112 (16%) Query: 6 EEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH--- 62 + P KL +E Q E I F + L+++ V+DK YSL+ DQIL E + Sbjct: 615 QHPMLSKL-IENIQKKVEGINFSIRKTLMEMDDVLDKQRRAVYSLR--DQILLEKDYDEY 671 Query: 63 -KELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFF--GCIGIDK 111 K++F+++V E+ +G W I+ + +FF G +D+ Sbjct: 672 LKDIFEDVVSTRVEEFCSG---------KNWDIESLKNSLSFFPAGLFDLDE 714 >5HFU-A nrPDB Length = 923 Score = 28.9 bits (63), Expect = 4.0, Method: Compositional matrix adjust. Identities = 62/285 (21%), Positives = 101/285 (35%), Gaps = 49/285 (17%) Query: 20 ALRENILFGMGNPLLDISAVVDKDFLDKYSLK----PNDQILAEDKHKELFDELVKKFKV 75 A+ E+I+ G G L D A +F+DK +K P + H+ DE F V Sbjct: 119 AIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDE---SFLV 175 Query: 76 EYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ 135 + G + G G D I K D Sbjct: 176 SWTKGFKSS--------------------GVEGRDVVALIRKAIQRRGDFDIDIVAVVND 215 Query: 136 PTGTCAACITGDNR---SLIANLAAANCYKKE-KHLDLEKNWMLVEKARVCYIAGFFLTV 191 GT C D+ LI + CY +E +H+D+ + ++ R+C + Sbjct: 216 TVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG----DEGRMCINMEWGAFG 271 Query: 192 SPESVLKVAHHASENNRIFTLN----LSAPFISQFYKESLMKV----MPYVDILFGNETE 243 S+ + + + +LN L IS Y L+++ M ++LFG + Sbjct: 272 DDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLS 331 Query: 244 AATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDT 288 + FETKDI +I + + ++ R V+ G D T Sbjct: 332 PELLNTGR-FETKDISDIEGEKDGI-----RKAREVLMRLGLDPT 370 >4IDE-A nrPDB Length = 332 Score = 28.5 bits (62), Expect = 4.6, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 26/49 (53%), Gaps = 4/49 (8%) Query: 57 LAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFG 105 LA D KE F++L +KF V Y A G T ++K +++ K T G Sbjct: 222 LAIDYTKENFEDLPEKFDVVYDAVGETDKAVKA----VKEGGKVVTIVG 266 >3LJS-A nrPDB Length = 338 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 11/17 (64%), Positives = 14/17 (82%) Query: 308 EIIDTNGAGDAFVGGFL 324 ++ D+N AGDAFVGG L Sbjct: 253 QVQDSNAAGDAFVGGML 269 >5MM8-A nrPDB Length = 204 Score = 28.1 bits (61), Expect = 5.6, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 1/38 (2%) Query: 195 SVLKVAHHASENNRIFTLNLSAPFISQF-YKESLMKVM 231 +LK+A A EN RI + P+I++F ES KV+ Sbjct: 102 GILKIASEAKENERISIVGYPEPYINKFQMYESTGKVL 139 >6C9R-A nrPDB Length = 337 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 20/42 (47%) Query: 311 DTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 D G GDAF GFL+ + L + G A +++ TG Sbjct: 264 DPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTG 305 >2RCM-A nrPDB Length = 495 Score = 28.1 bits (61), Expect = 6.4, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 27/47 (57%), Gaps = 3/47 (6%) Query: 8 PKPKKLKVEAPQALRENILFGMGNPLLDISA--VVDKDFLDKYSLKP 52 P KLK +AP + + +LF + +PLL I V+++ + +SL P Sbjct: 203 PADTKLKADAPGLITKWVLFNL-HPLLSIGLPRVIEEPLIHTFSLPP 248 >1U83-A nrPDB Length = 276 Score = 27.7 bits (60), Expect = 7.7, Method: Compositional matrix adjust. Identities = 20/96 (20%), Positives = 43/96 (44%), Gaps = 5/96 (5%) Query: 13 LKVEAPQALRENILFGMGNPLLDISAVVD--KDFLDKYSLKPNDQILAEDKHKELFDELV 70 ++ P+ ++IL G PL + D++D +L +D +++ + Sbjct: 32 VRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYIDFVKFGWGTSLLTKDLEEKI--STL 89 Query: 71 KKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGC 106 K+ + + GG+ V+Q + + H+ T+FGC Sbjct: 90 KEHDITFFFGGTLFEKY-VSQKKVNEFHRYCTYFGC 124 >3AL6-A nrPDB Length = 338 Score = 27.3 bits (59), Expect = 9.6, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 6/39 (15%) Query: 34 LDISAVVDKDFLDK---YSLKPNDQIL---AEDKHKELF 66 + ++AV DF+ K Y P DQ++ AE+KHKE F Sbjct: 83 IHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFF 121 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5KB6-A nrPDB 493 e-140 2I6B-A nrPDB 478 e-135 3LOO-A nrPDB 391 e-109 4N08-A nrPDB 351 2e-97 3UQ9-A nrPDB 344 4e-95 2AA0-A nrPDB 292 2e-79 4LC4-A nrPDB 241 4e-64 3UBO-A nrPDB 230 8e-61 3HJ6-A nrPDB 227 5e-60 3H49-A nrPDB 198 3e-51 1VM7-A nrPDB 197 7e-51 3RY7-A nrPDB 196 2e-50 2C4E-A nrPDB 193 8e-50 4X8F-A nrPDB 190 1e-48 5C40-A nrPDB 187 8e-48 6ILS-A nrPDB 186 9e-48 1RK2-A nrPDB 176 1e-44 5ZWY-A nrPDB 173 8e-44 1V1S-A nrPDB 161 3e-40 3GBU-A nrPDB 150 1e-36 2NWH-A nrPDB 146 2e-35 2QHP-A nrPDB 144 4e-35 3KD6-A nrPDB 123 1e-28 Sequences not found previously or not previously below threshold: 2QCV-A nrPDB 124 6e-29 2VAR-A nrPDB 122 3e-28 1TYY-A nrPDB 119 1e-27 5EYN-A nrPDB 115 2e-26 3LHX-A nrPDB 113 1e-25 6CW5-A nrPDB 111 4e-25 3IQ0-A nrPDB 111 5e-25 4DU5-A nrPDB 106 2e-23 4WJM-A nrPDB 97 1e-20 1WYE-A nrPDB 96 3e-20 2AFB-A nrPDB 95 5e-20 3PL2-A nrPDB 95 7e-20 3KZH-A nrPDB 92 4e-19 4E69-A nrPDB 90 2e-18 3LJS-A nrPDB 86 3e-17 2RBC-A nrPDB 83 2e-16 3NCA-A nrPDB 83 2e-16 3B1N-A nrPDB 83 2e-16 2HW1-A nrPDB 82 3e-16 3N1C-A nrPDB 80 1e-15 2ABQ-A nrPDB 80 1e-15 3I3Y-A nrPDB 80 2e-15 6C9R-A nrPDB 80 2e-15 4E84-A nrPDB 80 2e-15 3JUL-A nrPDB 77 1e-14 4GM6-A nrPDB 73 2e-13 3KTN-A nrPDB 73 2e-13 3BF5-A nrPDB 67 1e-11 3GO6-A nrPDB 67 2e-11 2JG5-A nrPDB 60 2e-09 2AJR-A nrPDB 59 3e-09 4S1M-A nrPDB 57 2e-08 5YSQ-A nrPDB 50 2e-06 3MBJ-A nrPDB 44 1e-04 2DDM-A nrPDB 43 3e-04 3HYO-A nrPDB 42 5e-04 4JJP-A nrPDB 42 5e-04 1YGJ-A nrPDB 39 0.003 5ZWB-B nrPDB 39 0.005 3ZS7-A nrPDB 38 0.005 2F7K-A nrPDB 38 0.006 1JXH-A nrPDB 36 0.019 4C5N-A nrPDB 36 0.021 5B6A-A nrPDB 35 0.043 1UB0-A nrPDB 35 0.054 4XF7-A nrPDB 35 0.059 5TRW-A nrPDB 34 0.077 5GJQ-a nrPDB 34 0.085 5LEZ-N nrPDB 34 0.099 6AVO-A nrPDB 33 0.22 6EPC-1 nrPDB 33 0.24 2QEQ-A nrPDB 33 0.33 1POI-B nrPDB 32 0.33 4FOI-A nrPDB 31 0.69 5LJ5-t nrPDB 30 1.7 4ZB4-A nrPDB 30 1.7 5TQI-A nrPDB 29 3.7 1V59-A nrPDB 29 4.7 4PXL-B nrPDB 29 4.8 3X1F-A nrPDB 28 6.8 3WIA-A nrPDB 28 6.8 >5KB6-A nrPDB Length = 363 Score = 493 bits (1269), Expect = e-140, Method: Composition-based stats. Identities = 329/360 (91%), Positives = 350/360 (97%) Query: 3 AAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH 62 AA +EPKPKKLKVEAPQAL EN+LFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH Sbjct: 4 AAADEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKH 63 Query: 63 KELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAE 122 KELFDELVKKFKVEYHAGGSTQNS+KVAQW+IQ+PHKAATFFGCIGIDKFGEILKRKAA+ Sbjct: 64 KELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRKAAD 123 Query: 123 AHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVC 182 AHVDAHYYEQNEQPTGTCAACITG NRSL+ANLAAANCYKKEKHLDLE+NW+LVEKARV Sbjct: 124 AHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLERNWVLVEKARVY 183 Query: 183 YIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNET 242 YIAGFFLTVSPESVLKVA +A+ENNR+FTLNLSAPFISQF+KE+LM VMPYVDILFGNET Sbjct: 184 YIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFISQFFKEALMDVMPYVDILFGNET 243 Query: 243 EAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVL 302 EAATFAREQGFETKDIKEIAKK QALPK+NSKRQR VIFTQGRDDTI+A E++VTAF VL Sbjct: 244 EAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFTQGRDDTIVAAENDVTAFPVL 303 Query: 303 DQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 362 DQ+Q+EIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAAS+IIRRTGCTFPEKPDFH Sbjct: 304 DQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH 363 >2I6B-A nrPDB Length = 345 Score = 478 bits (1229), Expect = e-135, Method: Composition-based stats. Identities = 341/343 (99%), Positives = 343/343 (100%) Query: 20 ALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA 79 ++RENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA Sbjct: 3 SVRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA 62 Query: 80 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT 139 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT Sbjct: 63 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT 122 Query: 140 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKV 199 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKV Sbjct: 123 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKV 182 Query: 200 AHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIK 259 AHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIK Sbjct: 183 AHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIK 242 Query: 260 EIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF 319 EIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF Sbjct: 243 EIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAF 302 Query: 320 VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 362 VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH Sbjct: 303 VGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH 345 >3LOO-A nrPDB Length = 365 Score = 391 bits (1005), Expect = e-109, Method: Composition-based stats. Identities = 175/345 (50%), Positives = 242/345 (70%), Gaps = 4/345 (1%) Query: 19 QALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYH 78 ++LR+ +L G+GNPLLDISAVV+KD L+KY ++PN+ ILAE+KH ++ EL++K++ EY Sbjct: 19 ESLRDGMLVGLGNPLLDISAVVEKDLLNKYDMQPNNAILAEEKHMPMYQELIEKYQAEYI 78 Query: 79 AGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTG 138 AGGS QNS++VAQW++Q+P + A FFGC+G D++ IL+ +A V+ Y PTG Sbjct: 79 AGGSVQNSLRVAQWILQRP-RTAIFFGCVGQDEYARILEERATSNGVNVQYQRSATSPTG 137 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLK 198 TCA +TG RSL ANLAAAN + E HL + N ++ A+ Y++GFF TVS ES L Sbjct: 138 TCAVLVTGTQRSLCANLAAANDFTPE-HLRSDGNRAYLQGAQFFYVSGFFFTVSFESALS 196 Query: 199 VAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDI 258 VA A+ R+F +NLSAPF+ QFYK +L ++ PYVD+LFGNETEA A+E + T+D+ Sbjct: 197 VAKEAAATGRMFMMNLSAPFVPQFYKNNLEEIFPYVDVLFGNETEAIALAKEFNYGTEDL 256 Query: 259 KEIAKKTQALPKMNSKRQRIVIFTQGRDDTIM--ATESEVTAFAVLDQDQKEIIDTNGAG 316 +EI K+ ALPK N KR+RIVI TQG D ++ A V F V ++++DTNGAG Sbjct: 257 REIGKRIAALPKENGKRKRIVIITQGSDPVLLIEAGTDNVREFPVQKLAPEQMVDTNGAG 316 Query: 317 DAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDF 361 DAFVGGFL+QL+ + + CI+ G +AA II+R+GCTF +P F Sbjct: 317 DAFVGGFLAQLLQSRTVDVCIKCGIWAAREIIQRSGCTFEGEPSF 361 >4N08-A nrPDB Length = 348 Score = 351 bits (900), Expect = 2e-97, Method: Composition-based stats. Identities = 135/332 (40%), Positives = 191/332 (57%), Gaps = 2/332 (0%) Query: 31 NPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVA 90 NPLLD+SA V +FL KY L+ IL ++ K +FD++ K V Y GGS N +VA Sbjct: 16 NPLLDVSAHVSDEFLVKYGLERGTAILLSERQKGIFDDIEKMPNVRYVPGGSGLNVARVA 75 Query: 91 QWMIQQ-PHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNR 149 QWM Q K T+ GCI D++G++LK A + + +G CA CITG R Sbjct: 76 QWMQQAYKGKFVTYVGCIADDRYGKVLKEAAEHEGIVMAVEHTTKAGSGACAVCITGKER 135 Query: 150 SLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRI 209 +L+A+L AAN E H+ ++++R+ Y +GF LTV VL+ A E + + Sbjct: 136 TLVADLGAANHLSSE-HMRSPAVVRAMDESRIFYFSGFTLTVDVNHVLQACRKAREVDGL 194 Query: 210 FTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALP 269 F +NLSAPFI QF+ L +V+PY DI+ N EA FA ++T ++EIA++ + Sbjct: 195 FMINLSAPFIMQFFSAQLGEVLPYTDIIVANRHEAKEFANMMKWDTDCVEEIARRAVSEV 254 Query: 270 KMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVS 329 + R+V+FT+ + T++AT+ V V DQ ++ID NGAGDAF+GGFLS Sbjct: 255 PYTGTKGRVVVFTRDIESTVLATKDGVETVPVPQLDQDKVIDMNGAGDAFMGGFLSAYAV 314 Query: 330 DKPLTECIRAGHYAASIIIRRTGCTFPEKPDF 361 K L C GHY A +I+R GC+FPEKP F Sbjct: 315 GKDLRRCCETGHYTAQEVIQRDGCSFPEKPSF 346 >3UQ9-A nrPDB Length = 372 Score = 344 bits (882), Expect = 4e-95, Method: Composition-based stats. Identities = 132/346 (38%), Positives = 204/346 (58%), Gaps = 8/346 (2%) Query: 21 LRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAG 80 L E +FGMGNPLLDI D KY+LK ++ +LAE+KH ++DE+ KK K+ Y AG Sbjct: 24 LSEGYVFGMGNPLLDIIVDADDFMYRKYNLKKDNIVLAEEKHMTIYDEIQKKKKLNYIAG 83 Query: 81 GSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQP--TG 138 G+T N++K+ QW+IQ+P ++ GCIG D G+ +K + + + + E+P TG Sbjct: 84 GATLNTVKMIQWIIQKPF-VCSYVGCIGADIQGKYIKNDCSALDLVTEF-QIAEEPLMTG 141 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLK 198 A ++ RS++ L AA C H++ W LVEKA+V YIAGF + E +LK Sbjct: 142 KVAVLVSEKLRSMVTYLGAA-CDLSLAHIEQPHVWSLVEKAQVYYIAGFVINTCYEGMLK 200 Query: 199 VAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDI 258 +A H+ EN ++F NLSAPF+SQF + + +++ Y +I+FGNE+EA + G + Sbjct: 201 IAKHSLENEKLFCFNLSAPFLSQFNTKEVDEMISYSNIVFGNESEAEAYGEVHGLLEDTV 260 Query: 259 KEIAKKTQALPKMNS-KRQRIVIFTQGRDDTIM--ATESEVTAFAVLDQDQKEIIDTNGA 315 A+ LP + KR+R+VI T+G++ + +++SE+ F V +IIDTNGA Sbjct: 261 HATARYIADLPFADGKKRKRLVIITRGKNPLLYTDSSDSEIHQFMVEQFKDDQIIDTNGA 320 Query: 316 GDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDF 361 GDAF GF++ + KP+ + A AA+ II R+G + + + Sbjct: 321 GDAFAAGFIADYIRGKPMITSLHAAVKAAAYIICRSGFSLGSRDSY 366 >2AA0-A nrPDB Length = 383 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 114/369 (30%), Positives = 181/369 (49%), Gaps = 29/369 (7%) Query: 8 PKPKKLKVEAPQALRENI-LFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELF 66 P+ + V++ + + +F +GNP+LD+ A V FLD++ LK D LA + ++ Sbjct: 16 PRGSHMAVDSSNSATGPMRVFAIGNPILDLVAEVPSSFLDEFFLKRGDATLATPEQMRIY 75 Query: 67 DELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVD 126 L +F GGS NS++V Q ++++P A + G IG D G++LK + + Sbjct: 76 STL-DQFNPTSLPGGSALNSVRVVQKLLRKPGS-AGYMGAIGDDPRGQVLKELCDKEGLA 133 Query: 127 AHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWM-LVEKARVCYIA 185 + Q TG CA I R+L +L A + L ++W A + Y Sbjct: 134 TRFMVAPGQSTGVCAVLINEKERTLCTHLGACGSF------RLPEDWTTFASGALIFYAT 187 Query: 186 GFFLTVSPESVLKVAHHASE-NNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEA 244 + LT +P++ L+VA +A N IFTLNLSAPF + YK+++ ++ + +ILFGNE E Sbjct: 188 AYTLTATPKNALEVAGYAHGIPNAIFTLNLSAPFCVELYKDAMQSLLLHTNILFGNEEEF 247 Query: 245 ATFAREQGFET--KDIKEIAKKTQAL-----------PKMNSKRQRIVIFTQGRDDTIMA 291 A A+ K A K A+ N+ ++V+ T+G + I A Sbjct: 248 AHLAKVHNLVAAEKTALSTANKEHAVEVCTGALRLLTAGQNTSATKLVVMTRGHNPVIAA 307 Query: 292 TESE-----VTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASI 346 ++ V V ++I+DTNGAGDAFVGGFL L K + +CI G+ A Sbjct: 308 EQTADGTVVVHEVGVPVVAAEKIVDTNGAGDAFVGGFLYALSQGKTVKQCIMCGNACAQD 367 Query: 347 IIRRTGCTF 355 +I+ G + Sbjct: 368 VIQHVGFSL 376 >4LC4-A nrPDB Length = 352 Score = 241 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 85/343 (24%), Positives = 145/343 (42%), Gaps = 37/343 (10%) Query: 19 QALRENILFGMGNPLLDISAVVDKDFL-DKYSLKPNDQILAEDKHKELFDELVKKFKVEY 77 Q++ + +GN ++DI + + FL D K ++ ++ + L+ + + Sbjct: 21 QSMTRFDVLTVGNAIVDIISRCNDQFLIDNQITKAAMNLIDAERAELLYSRMGPALEA-- 78 Query: 78 HAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ-- 135 +GGS N+ A + KAA +FG + D+ G+I V HY + + Sbjct: 79 -SGGSAGNT---AAGVANLGGKAA-YFGNVAADQLGDIFTHDIRAQGV--HYQTKPKGAF 131 Query: 136 -PTGTCAACITGDN-RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLT--V 191 PT +T D RS+ L A E + +V A+V Y G+ Sbjct: 132 PPTARSMIFVTEDGERSMNTYLGACVELGPE-----DVEADVVADAKVTYFEGYLWDPPR 186 Query: 192 SPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPY--VDILFGNETEAATFAR 249 + E++L A A ++ R ++ LS F Y+ + +M VDI+F N EA + Sbjct: 187 AKEAILDCARIAHQHGREMSMTLSDSFCVDRYRGEFLDLMRSGKVDIVFANRQEALSL-- 244 Query: 250 EQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEI 309 ++T D +E + A K I T + ++ E + V +E+ Sbjct: 245 ---YQTDDFEEALNRIAADCK-------IAAVTMSENGAVILKGRE--RYYVNAIRIREV 292 Query: 310 IDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 +DT GAGD F GFL + L +C + G AA I+I++ G Sbjct: 293 VDTTGAGDLFASGFLYGYTQGRSLEDCGKLGCLAAGIVIQQIG 335 >3UBO-A nrPDB Length = 354 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 82/336 (24%), Positives = 145/336 (43%), Gaps = 37/336 (11%) Query: 26 LFGMGNPLLDISAVVDKDFLDKYSL-KPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQ 84 + +GN ++DI A D FL++ + K ++ D+ + L+ + + +GGS Sbjct: 8 VLTIGNAIVDIIARCDDSFLEENGIIKGAMNLINADRAELLYSRMGPAVEA---SGGSAG 64 Query: 85 NSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQN---EQPTGTCA 141 N+ A + +AA +FG + D+ GEI V H+ + PT Sbjct: 65 NT---AAGVASLGGRAA-YFGKVADDQLGEIFTHDIRAQGV--HFQTKPLDGHPPTARSM 118 Query: 142 ACITGDN-RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLT--VSPESVLK 198 +T D RS+ L A E D+E + +V +++V Y G+ + +++ + Sbjct: 119 IFVTEDGERSMNTYLGACVELGPE---DVEDD--VVAQSKVTYFEGYLWDPPRAKDAIRE 173 Query: 199 VAHHASENNRIFTLNLSAPFISQFYKESLMKVM--PYVDILFGNETEAATFAREQGFETK 256 A A + R + LS F Y+ +++M VDI+F N EA +ET+ Sbjct: 174 AARIAHAHGRETAMTLSDSFCVHRYRSEFLELMRSGTVDIVFANRQEALAL-----YETE 228 Query: 257 DIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAG 316 D + L + K + T + +++ V ++++DT GAG Sbjct: 229 DF----DRALELLARDCK---LAAVTLSEEGSVVV--RGAERVRVGASVLEQVVDTTGAG 279 Query: 317 DAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 D + GFL S + L EC + G+ AA I+I + G Sbjct: 280 DLYAAGFLFGYTSGRSLEECSKLGNLAAGIVIGQIG 315 >3HJ6-A nrPDB Length = 327 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 74/346 (21%), Positives = 128/346 (36%), Gaps = 47/346 (13%) Query: 23 ENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGS 82 E ++ G+ N +S K LD SL +IL + E + L + + H GGS Sbjct: 4 EGVIVGILNKNFSLS----KGDLDVVSLG---EILVDMISTEEVNSLSQSREYTRHFGGS 56 Query: 83 TQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAA 142 N I V + + K +G D FG L + +Q+++ T Sbjct: 57 PAN-IAVN---LSRLGKKVALISRLGADAFGNYLLDVLKGEQIITDGIQQDKERRTTIVY 112 Query: 143 CITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSP--ESVLKVA 200 A+ Y +E + E L+++++V +++ F L+ P ++ +K Sbjct: 113 VSKSTRTPDWLPYREADMYLQEDDIIFE----LIKRSKVFHLSTFILSRKPARDTAIKAF 168 Query: 201 HHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKE 260 ++A E +I + Y +L+ + A E +K Sbjct: 169 NYAREQGKIVCFDPC-----------------YRKVLWPEGDDGAGVVEEIISRADFVKP 211 Query: 261 IAKKTQAL-----PKMNSKRQ-----RIVIFTQGRDDTIMATESEVTAFAVLDQDQKEII 310 + L P+ KR + VI T G + I + E+ +D + Sbjct: 212 SLDDARHLFGPDSPENYVKRYLELGVKAVILTLGEEGVIASDGEEIIRIPAFSED---AV 268 Query: 311 DTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFP 356 D GAGDAF GF+ L+ + I+ G+ A+ IR G P Sbjct: 269 DVTGAGDAFWSGFICGLLDGYTVKRSIKLGNGVAAFKIRGVGALSP 314 >3H49-A nrPDB Length = 325 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 130/321 (40%), Gaps = 26/321 (8%) Query: 43 DFLDKYSLKPND-QILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAA 101 D LD + I + K +FD V + +E A + ++I A + + H+ A Sbjct: 4 DNLDVICIGAAIVDIPLQPVSKNIFD--VDSYPLERIAMTTGGDAINEATIISRLGHRTA 61 Query: 102 TFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ-PTGTCAACITGDN-RSLIANLAAAN 159 IG D G+ + + ++D +Q+ T +T D R+ + N N Sbjct: 62 -LMSRIGKDAAGQFILDHCRKENIDIQSLKQDVSIDTSINVGLVTEDGERTFVTN---RN 117 Query: 160 CYKKEKHLDLEKNWMLVEKARVCYIAGFFLT--VSPESVLKVAHHASENNRIFTLNLSAP 217 + ++D + ++ +A++ +A F + + +++ ++ A I ++ P Sbjct: 118 GSLWKLNID-DVDFARFSQAKLLSLASIFNSPLLDGKALTEIFTQAKARQMIICADMIKP 176 Query: 218 FISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQR 277 +++ + + + + YVD LF N EA + + + EIA A + Sbjct: 177 RLNETL-DDICEALSYVDYLFPNFAEAKLLTGK-----ETLDEIADCFLAC------GVK 224 Query: 278 IVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECI 337 V+ G+D + V IDT GAGD F GF++ L+ K L EC Sbjct: 225 TVVIKTGKDGCFIKRGD--MTMKVPAVAGITAIDTIGAGDNFASGFIAALLEGKNLRECA 282 Query: 338 RAGHYAASIIIRRTGCTFPEK 358 R + A+I + G T K Sbjct: 283 RFANATAAISVLSVGATTGVK 303 >1VM7-A nrPDB Length = 311 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 113/302 (37%), Gaps = 31/302 (10%) Query: 54 DQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFG 113 D +L D + + + G ++ VA+ K F CIG D + Sbjct: 26 DIVLKVDHFTKPGETQKAIEMNVFPGGKGANQAVTVAKI----GEKGCRFVTCIGNDDYS 81 Query: 114 EILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNW 173 ++L + + Y + PTG + ++ I AN K++ + +W Sbjct: 82 DLLIENYEKLGI--TGYIRVSLPTGRAFIEVDKTGQNRIIIFPGANAELKKELI----DW 135 Query: 174 MLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPY 233 + ++ + + + E+ L+ A R + + P +Q E + + Y Sbjct: 136 NTLSESDILLLQN---EIPFETTLECAK------RFNGIVIFDPAPAQGINEEIFQ---Y 183 Query: 234 VDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATE 293 +D L NE E +++ E +++ A+K L N VI G ++ + Sbjct: 184 LDYLTPNEKEIEALSKDFFGEFLTVEKAAEKFLELGVKN------VIVKLGDKGVLLVNK 237 Query: 294 SEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGC 353 +E F + + +DT AGD F G F L K E + G AA+I + R G Sbjct: 238 NEKKHFPTF---KVKAVDTTAAGDVFNGAFAVALSEGKNPEEAVIFGTAAAAISVTRLGA 294 Query: 354 TF 355 Sbjct: 295 QS 296 >3RY7-A nrPDB Length = 304 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 124/304 (40%), Gaps = 28/304 (9%) Query: 54 DQILAEDKHKELFDEL-VKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKF 112 DQ L +++ + + L V++ + + G +I A+ TF IG D Sbjct: 14 DQFLTVERYAQPGETLHVEEAQKAFGGGKGANQAIATARM-----QADTTFITKIGTDGV 68 Query: 113 GEILKRKAAEAHVDAHYY-EQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEK 171 + + AH+D Y + E TG + + ++ I AN + + K Sbjct: 69 ADFILEDFKVAHIDTSYIIKTAEAKTGQAFITVNAEGQNTIYVYGGANMTMTPEDVINAK 128 Query: 172 NWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVM 231 + ++ V L V +++ A + LN AP K +++ Sbjct: 129 DAIINADFVVAQ-----LEVPIPAIISAFEIAKAHGVTTVLN-PAPA-----KALPNELL 177 Query: 232 PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA 291 +DI+ NETEA + + + +K+ A ++ + V+ T G+ T A Sbjct: 178 SLIDIIVPNETEAELLSGIKVTNEQSMKDNANYFLSI------GIKTVLITLGKQGTYFA 231 Query: 292 TESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL-VSDKPLTECIRAGHYAASIIIRR 350 T+++ + + IDT AGD F+G F+S+L S L + I G+ A+S+ +++ Sbjct: 232 TKNQSQHI---EAYKVNAIDTTAAGDTFIGAFVSRLNKSQDNLADAIDFGNKASSLTVQK 288 Query: 351 TGCT 354 G Sbjct: 289 HGAQ 292 >2C4E-A nrPDB Length = 302 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 115/304 (37%), Gaps = 39/304 (12%) Query: 54 DQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFG 113 D I +K E + +Y+ G + ++ + + + + C+G D Sbjct: 17 DYIFNVEKFPEPNTSIQIPSARKYYGGAAANTAVGIKKLGVN-----SELLSCVGYDFKN 71 Query: 114 EILKRKAA--EAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEK 171 +R + ++ YY + E+ +N+ AA YK+ + Sbjct: 72 SGYERYLKNLDINISKLYYSEEEETPKAWIFTDKDNNQITFFLWGAAKHYKELNPPNF-- 129 Query: 172 NWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRI-FTLNLSAPFISQFYKESLMKV 230 + +IA T PE LK A A NN + F P Q+ KE L+++ Sbjct: 130 ------NTEIVHIA----TGDPEFNLKCAKKAYGNNLVSFDPGQDLP---QYSKEMLLEI 176 Query: 231 MPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIM 290 + + + LF N+ E + FE D E R +I T+G +++ Sbjct: 177 IEHTNFLFMNKHEFERASNLLNFEIDDYLE--------------RVDALIVTKGSKGSVI 222 Query: 291 ATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRR 350 T+ + + ++ID GAGD++ GFLS V L +C G AS ++ Sbjct: 223 YTKDKKIEIPCIKAG--KVIDPTGAGDSYRAGFLSAYVKGYDLEKCGLIGAATASFVVEA 280 Query: 351 TGCT 354 GC Sbjct: 281 KGCQ 284 >4X8F-A nrPDB Length = 309 Score = 190 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 106/303 (34%), Gaps = 26/303 (8%) Query: 53 NDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKF 112 D +L + L + G ++ A+ F C+G D F Sbjct: 15 ADHVLQVPSFPRPGETLHGRNYQVIPGGKGANQAVAAARM-----QADVGFIACVGDDSF 69 Query: 113 GEILKRKAAEAHVDAHYYE-QNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEK 171 G ++ ++ + Q PTG ++ + I A AN + E Sbjct: 70 GINIRESFKLDGINTAGVKLQPNCPTGIAMIQVSDSGENSICISAEANAKLTAAAI--EP 127 Query: 172 NWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVM 231 + + AR + L + +LK A A LN AP +E +++ Sbjct: 128 DLAAIRDARYLLMQ---LETPLDGILKAAQEAKTAKTNVILN-PAPA-----RELPDELL 178 Query: 232 PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA 291 VD++ NETEA ++ ++ A ++ K IVI T G ++ Sbjct: 179 KCVDLITPNETEAEVLTGITVYDDSSAQQAADA------LHCKGIEIVIITLGSKGVWLS 232 Query: 292 TESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRT 351 + DT AGD F G ++ L+ + PL I+ H AA+I + R Sbjct: 233 QNGRGQRIPGF---VVKATDTTAAGDTFNGALVTGLLQEMPLESAIKFAHAAAAISVTRF 289 Query: 352 GCT 354 G Sbjct: 290 GAQ 292 >5C40-A nrPDB Length = 330 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 114/288 (39%), Gaps = 27/288 (9%) Query: 79 AGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHY-YEQNEQPT 137 G ++ A+ + +G D FG + + + Y+ + T Sbjct: 52 GGKGANQCVQAARL-----GAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAAT 106 Query: 138 GTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVL 197 GT + + + +++I +A AN + L N + K VC L ++P + L Sbjct: 107 GTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQ-----LEITPATSL 161 Query: 198 KVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKD 257 + A + + TL AP I+ + D+ NE+EA G Sbjct: 162 EALTMARRSG-VKTLFNPAPAIADLDP----QFYTLSDVFCCNESEAEILT---GLTVGS 213 Query: 258 IKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGD 317 + + L K + ++VI T G + ++ +++E + + + + +DT GAGD Sbjct: 214 AADAGEAALVLLK---RGCQVVIITLGAEGCVVLSQTEPEPKHIPTE-KVKAVDTTGAGD 269 Query: 318 AFVG--GFLSQLVSDKPLTECIRAGHYAASIIIRRTGC--TFPEKPDF 361 +FVG F + L + + ++ A++ ++ G ++P K D Sbjct: 270 SFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDL 317 >6ILS-A nrPDB Length = 313 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 121/323 (37%), Gaps = 33/323 (10%) Query: 45 LDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFF 104 L D + ++ + + + K G + A+ M F Sbjct: 5 LVVVGSANADIYVEIERLPKEGETISAKTGQTLAGGKGANQAACGAKLMY-----PTYFV 59 Query: 105 GCIGIDKFGEILKRKAAEAHVDAH---YYEQNEQPTGTCAACITGDNRSLIANLAAANCY 161 G +G D G+++ + H N +PTG + D ++ I + AN Sbjct: 60 GRLGEDAHGKLIAEALGDDGCGVHLDYVRSVNNEPTGHAVVMLQSDGQNSIIIVGGANM- 118 Query: 162 KKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESV-LKVAHHASENNRIFTLN---LSAP 217 K + + + +V A + + P+S+ ++VA + L+ + P Sbjct: 119 KAWPEIMSDDDLEIVRNAGIVLLQREI----PDSINIQVAKAVKKAGVPVILDVGGMDTP 174 Query: 218 FISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQR 277 + +++ +DIL NETE +R G T+ ++I++ K+ K+ Sbjct: 175 IPN--------ELLDSIDILSPNETE---LSRLTGMPTETFEQISQAVAKCHKLGVKQ-- 221 Query: 278 IVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECI 337 V+ G + + + E +++DT GAGD F F +V K EC+ Sbjct: 222 -VLVKLGSKGSALFIQGEKP-IQQSIIPAAQVVDTTGAGDTFTAAFAVAMVEGKSHEECL 279 Query: 338 RAGHYAASIIIRRTGCTFPEKPD 360 R AAS+ ++ G P PD Sbjct: 280 RFAAAAASLCVQVKGA-IPSMPD 301 >1RK2-A nrPDB Length = 309 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 121/308 (39%), Gaps = 27/308 (8%) Query: 53 NDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKF 112 D IL + + G ++ + F C G D Sbjct: 15 ADHILNLQSFPTPGETVTGNHYQVAFGGKGANQAVAAGRSGAN-----IAFIACTGDDSI 69 Query: 113 GEILKRKAAEAHVDAHYYEQ-NEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEK 171 GE ++++ A ++D + TG + G+ ++I A AN ++ ++ Sbjct: 70 GESVRQQLATDNIDITPVSVIKGESTGVALIFVNGEGENVIGIHAGANAALSPALVEAQR 129 Query: 172 NWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVM 231 + A + + ESV+ A A +N I LN AP +E +++ Sbjct: 130 ERIANASALLMQLES-----PLESVMAAAKIAHQNKTIVALN-PAPA-----RELPDELL 178 Query: 232 PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA 291 VDI+ NETEA G ++ ++ AK Q L + + I + ++G ++ Sbjct: 179 ALVDIITPNETEAEKLT---GIRVENDEDAAKAAQVLHEKGIRTVLITLGSRGVWASVNG 235 Query: 292 TESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRT 351 V F V + +DT AGD F G ++ L+ +KPL E IR H AA+I + R Sbjct: 236 EGQRVPGFRV------QAVDTIAAGDTFNGALITALLEEKPLPEAIRFAHAAAAIAVTRK 289 Query: 352 GCTFPEKP 359 G P P Sbjct: 290 GAQ-PSVP 296 >5ZWY-A nrPDB Length = 349 Score = 173 bits (439), Expect = 8e-44, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 99/282 (35%), Gaps = 18/282 (6%) Query: 79 AGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHY-YEQNEQPT 137 G ++ + + +G D G ++ VD Y + + T Sbjct: 72 GGKGANQAVAAGRLGAK-----VAMVSMVGTDGDGSDYIKELERNGVDTAYMFRTGKSST 126 Query: 138 GTCAACI--TGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPES 195 G + N ++ A N + E N+ + + Y+ + + Sbjct: 127 GLAMILVDTKSSNNEIVICPNATNHFTPELLRAQTNNYERILHTGLKYLICQ-NEIPLPT 185 Query: 196 VLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFET 255 L A ++T+ SAP E + +PYV + NE EA G + Sbjct: 186 TLDTIKEAHSRG-VYTVFNSAPAPKPAEVEQIKPFLPYVSLFCPNEVEATLIT---GVKV 241 Query: 256 KDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGA 315 D + +AL ++ R V+ T G ++ +E+ V + + +DT GA Sbjct: 242 TDTESAFSAIKALQQL---GVRDVVITLGAAGFVL-SENGAEPVHVTGKHV-KAVDTTGA 296 Query: 316 GDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPE 357 GD FVG + + + L E + + A+I + R G Sbjct: 297 GDCFVGSMVYFMSRGRNLLEACKRANECAAISVTRKGTQLSY 338 >1V1S-A nrPDB Length = 309 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 114/306 (37%), Gaps = 43/306 (14%) Query: 69 LVKKFKVEYHAGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDA 127 L K +E + GG+ N ++ +A+ ++ F G +G D+ G +++ + VD Sbjct: 22 LRGKRLLEVYVGGAEVNVAVALARLGVK-----VGFVGRVGEDELGAMVEERLRAEGVDL 76 Query: 128 HYYEQNEQPTGTCA--ACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIA 185 ++ + TG G R +A D + +E R +++ Sbjct: 77 THFRRAPGFTGLYLREYLPLGQGRVFYYRKGSAGSALAPGAFDPD----YLEGVRFLHLS 132 Query: 186 GFFLTVSPES-VLKVAHHASENNRIFTLNLSAPFISQFY-----KESLMKVMPYVDILFG 239 G +SPE+ + R ++L + + + L + +P VD+LF Sbjct: 133 GITPALSPEARAFSLWAMEEAKRRGVRVSLDVNYRQTLWSPEEARGFLERALPGVDLLFL 192 Query: 240 NETEAATFAR--EQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVT 297 +E EA E+ E+ K A +G + E + Sbjct: 193 SEEEAELLFGRVEEALRALSAPEVVLKRGA---------------KGAWAFVDGRRVEGS 237 Query: 298 AFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG--CTF 355 AFAV E +D GAGDAF G+L+ V P+ E +R + + + G Sbjct: 238 AFAV------EAVDPVGAGDAFAAGYLAGAVWGLPVEERLRLANLLGASVAASRGDHEGA 291 Query: 356 PEKPDF 361 P + D Sbjct: 292 PYREDL 297 >3GBU-A nrPDB Length = 313 Score = 150 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 67/319 (21%), Positives = 125/319 (39%), Gaps = 45/319 (14%) Query: 55 QILAEDKHKELFDELVKKFKVEYHAGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDKFG 113 ++L + E D L E H GG+ N ++ V++ ++ ++ +G D FG Sbjct: 9 ELLIDLISVEEGD-LKDVRLFEKHPGGAPANVAVGVSRLGVK-----SSLISKVGNDPFG 62 Query: 114 EILKRKAAEAHVDAHYYEQNEQP-TGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKN 172 E L + ++ +VD ++E+ TG + G + S + A + N Sbjct: 63 EYLIEELSKENVDTRGIVKDEKKHTGIVFVQLKGASPSFLLYDDVAYFNMTLNDI----N 118 Query: 173 WMLVEKARVCYIAGFFLTVSP--ESVLKVAHHASENNRI-FTLNLSAPFISQFYKESLMK 229 W +VE+A++ L +P E+V+KV ++ I F +NL + + +E ++K Sbjct: 119 WDIVEEAKIVNFGSVILARNPSRETVMKVIKKIKGSSLIAFDVNLRLD-LWRGQEEEMIK 177 Query: 230 VM----PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGR 285 V+ DI+ +E E + QG E K + T G Sbjct: 178 VLEESIKLADIVKASEEEV-LYLENQGVEV------------------KGSMLTAITLGP 218 Query: 286 DDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL--VSDKPLTECIRAGHYA 343 + V +DT GAGDAF+ L + + L + + + Sbjct: 219 KGFRLIKNETVVDVP---SYNVNPLDTTGAGDAFMAALLVGILKLKGLDLLKLGKFANLV 275 Query: 344 ASIIIRRTGC-TFPEKPDF 361 A++ ++ G + P K + Sbjct: 276 AALSTQKRGAWSTPRKDEL 294 >2NWH-A nrPDB Length = 317 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 108/281 (38%), Gaps = 29/281 (10%) Query: 79 AGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTG 138 AGG N+ + + + G D GE++ A +A V+ + ++ T Sbjct: 38 AGGGGFNAAR----NLSRLGFEVRIIAPRGGDVTGEVVAEAARQAGVEDTPFTFLDRRTP 93 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVS---PES 195 + A + D +IA LA + YK + V R IA FL PE Sbjct: 94 SYTAILERDGNLVIA-LADMDLYKL-----FTPRRLKVRAVREAIIASDFLLCDANLPED 147 Query: 196 VLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFET 255 L + R L+A IS L + +DILF NE EA E Sbjct: 148 TLTALGLIA---RACEKPLAAIAISPAKAVKLKAALGDIDILFMNEAEARALTGETAENV 204 Query: 256 KDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQ-KEIIDTNG 314 +D I +K + T+G + + +E A+L +E+ D G Sbjct: 205 RDWPNILRKAGLSGG---------VVTRGASEVVAFNGTEK---AILHPPLIREVKDVTG 252 Query: 315 AGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTF 355 AGDA G+L+ + K + E +R G AA+I ++ + T Sbjct: 253 AGDAMASGYLAAIAEGKTIREALRQGAAAAAITVQSSFATS 293 >2QHP-A nrPDB Length = 296 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 114/299 (38%), Gaps = 21/299 (7%) Query: 64 ELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEA 123 + + L GG+ N + + Q + +G D+ G+ + E Sbjct: 8 GMGEALWDVLPEGKKIGGAPANF----AYHVSQFGFDSRVVSAVGNDELGDEIMEVFKEK 63 Query: 124 HVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCY 183 + E+ + PTGT + + + + D K L +A Sbjct: 64 QLKNQ-IERVDYPTGTVQVTLDDEGVP-CYEIKEGVAWDNIPFTDELKRLALNTRAVCFG 121 Query: 184 IAGFFLTVSPESV---LKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN 240 VS ++ L +IF +NL F + KE L + +IL N Sbjct: 122 SLAQRNEVSRATINRFLDTMPDIDGQLKIFDINLRQDF---YTKEVLRESFKRCNILKIN 178 Query: 241 ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA 300 + E T +R G+ D+++ K L K N K ++I T G + + + T V +F Sbjct: 179 DEELVTISRMFGYPGIDLQD--KCWILLAKYNLK---MLILTCGINGSYVFTP-GVVSFQ 232 Query: 301 VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKP 359 + + + DT GAGD+F F + +++ K + E + ++ + ++G PE P Sbjct: 233 --ETPKVPVADTVGAGDSFTAAFCASILNGKSVPEAHKLAVEVSAYVCTQSGA-MPELP 288 >2QCV-A nrPDB Length = 332 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 60/329 (18%), Positives = 117/329 (35%), Gaps = 32/329 (9%) Query: 42 KDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAA 101 D ++ L ++ + + + GGS N + + A Sbjct: 9 DREFDLIAIGRACIDLNAVEYNRP---MEETMTFSKYVGGSPANIV----IGSSKLGLKA 61 Query: 102 TFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ--PTGTCAACITGDNRSLIANLAA-- 157 F G I D+ G ++ VD +++ TG I I Sbjct: 62 GFIGKIADDQHGRFIESYMRGVGVDTSNLVVDQEGHKTGLAFTEIKSPEECSILMYRQDV 121 Query: 158 ANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSP--ESVLKVAHHASENNRIFTLNLS 215 A+ Y + E N + ++++ ++G L+ SP E+VLK A N+ L Sbjct: 122 ADLYLSPE----EVNEAYIRRSKLLLVSGTALSKSPSREAVLKAIRLAKRNDVKVVFELD 177 Query: 216 APFISQFYKESLMKVMPYV----DILFGNETEAATFAREQGFETKDIKEIAKKTQALPKM 271 S E V DI+ G E + + + + I + P++ Sbjct: 178 YRPYSWETPEETAVYYSLVAEQSDIVIGTREEFDVL-ENRTEKGDNDETIRYLFKHSPEL 236 Query: 272 NSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDK 331 ++ G + + T++ A+ + +++ T GAGD++ FL L+S K Sbjct: 237 -------IVIKHGVEGSFAYTKAG-EAYRGYAY-KTKVLKTFGAGDSYASAFLYALISGK 287 Query: 332 PLTECIRAGHYAASIIIRRTGCTFPEKPD 360 + ++ G +ASI++ + + P Sbjct: 288 GIETALKYGSASASIVVSKH-SSSDAMPS 315 >3KD6-A nrPDB Length = 313 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 100/287 (34%), Gaps = 49/287 (17%) Query: 80 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGT 139 GGS+ A + +P + G +G D FG+ ++D Sbjct: 28 GGSSTYIALSASYFTDEPIR---MVGVVGSD-FGKEHFDLLHAKNIDTRG---------- 73 Query: 140 CAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKA-----RVCYIAGFFL--TVS 192 + D ++ A Y L+ + + + + F + Sbjct: 74 --IQVIEDGKTF--RWAGRYHYDMNTRDTLDTQLNVFAEFDPHVPQYYRDSKFVCLGNID 129 Query: 193 PESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQG 252 PE LKV + + + F + E L KV+ VD+ N++EA + + Sbjct: 130 PELQLKVLDQIDDPKLVVCDTM--NFWIEGKPEELKKVLARVDVFIVNDSEARLLSGDPN 187 Query: 253 F--ETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEII 310 + I+E+ K +I +G ++ T++ + FA + I Sbjct: 188 LVKTARIIREMGPK-------------TLIIKKGEHGALLFTDNGI--FAAPAFPLESIY 232 Query: 311 DTNGAGDAFVGGFLSQL-----VSDKPLTECIRAGHYAASIIIRRTG 352 D GAGD F GGF+ L S+ + + + G AS + + G Sbjct: 233 DPTGAGDTFAGGFIGHLARCGNTSEAEMRKAVLYGSAMASFCVEQFG 279 >2VAR-A nrPDB Length = 313 Score = 122 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 54/287 (18%), Positives = 108/287 (37%), Gaps = 32/287 (11%) Query: 76 EYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ 135 E H GS N + + H + + +G D+FG+ + + +D + + + + Sbjct: 29 EKHVAGSELNFC----IAVVRNHLSCSLIARVGNDEFGKNIIEYSRAQGIDTSHIKVDNE 84 Query: 136 P-TGTCAAC----ITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLT 190 TG I + + +A + + N V +R+ + G L Sbjct: 85 SFTGIYFIQRGYPIPMKSELVYYRKGSAGSRLSPEDI----NENYVRNSRLVHSTGITLA 140 Query: 191 VS---PESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDI--LFGNETEAA 245 +S E+V+K A + + + KE+++ ++ DI L + + Sbjct: 141 ISDNAKEAVIKAFELAKSRSLDTNIRPKLWSSLEKAKETILSILKKYDIEVLITDPDDTK 200 Query: 246 TFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQD 305 + D E +K + L +++++ G I + V AF D Sbjct: 201 IL-----LDVTDPDEAYRKYKEL------GVKVLLYKLGSKGAIAY-KDNVKAFK--DAY 246 Query: 306 QKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 + + D GAGDA G F+S + K + + G A++++I G Sbjct: 247 KVPVEDPTGAGDAMAGTFVSLYLQGKDIEYSLAHGIAASTLVITVRG 293 >1TYY-A nrPDB Length = 339 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 99/303 (32%), Gaps = 42/303 (13%) Query: 68 ELVKKFKVEY---HAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAH 124 +LV + + Y G S + VA+ F GC+G D G L++ + Sbjct: 36 DLVPEKQNSYLKCPGGASANVGVCVARL-----GGECGFIGCLGDDDAGRFLRQVFQDNG 90 Query: 125 VDAHYYEQNEQPTGTCAAC-ITGDNRSLIANL--AAANCYKKEKHLDLEKNWMLVEKARV 181 VD + + T +T D L A+ Y + L + Sbjct: 91 VDVTFLRLDADLTSAVLIVNLTADGERSFTYLVHPGADTYVSPQDLPP------FRQYEW 144 Query: 182 CYIAGFFLTVSP--ESVLKVAHHASENN--RIFTLNLSAPFI--SQFYKESLMKVMPYVD 235 Y + LT P E+ L+ A E +F +NL + + E + + Sbjct: 145 FYFSSIGLTDRPAREACLEGARRMREAGGYVLFDVNLRSKMWGNTDEIPELIARSAALAS 204 Query: 236 ILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESE 295 I + E + ++ + L I + G D ++ T Sbjct: 205 ICKVSADELCQLSG-----ASHWQDARYYLRDL------GCDTTIISLGADGALLITAEG 253 Query: 296 VTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSD-----KPLTECIRAGHYAASIIIRR 350 F D ++DT GAGDAFVGG L L L E I + ++ + Sbjct: 254 EFHFPAPRVD---VVDTTGAGDAFVGGLLFTLSRANCWDHALLAEAISNANACGAMAVTA 310 Query: 351 TGC 353 G Sbjct: 311 KGA 313 >5EYN-A nrPDB Length = 323 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 107/291 (36%), Gaps = 41/291 (14%) Query: 79 AGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNE-QP 136 GG+ N ++ +A+ + + FFG +G D FG +++ + VD + + Sbjct: 43 PGGAPANVAVAIARLSGR-----SAFFGRVGNDPFGRFMQQTLTDEQVDCQHLHFDPVHR 97 Query: 137 TGTCAACITGDNRSLIANL--AAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPE 194 T T + + +A+ + + + +K ++ L P Sbjct: 98 TSTVVVDLDEHGERSFTFMVKPSADQFLQLSDIPS------FQKGEWLHVCSIALANQPS 151 Query: 195 --SVLKVAHHASENN--RIFTLNLSAPFIS--QFYKESLMKVMPYVDILFGNETEAATFA 248 S E F NL S Q + ++M+ + D++ +E E Sbjct: 152 RSSTFAAIAQMKEVGGYVSFDPNLREEVWSEPQELQATVMRAVGLADVVKFSEEELQFLT 211 Query: 249 REQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKE 308 T+ I+E + +V+ T G ++AT + + ++ + Sbjct: 212 G-----TQSIEEGLQAIADFQ------IPLVVVTLGAKGALVATPN---SQQIVSGKAVK 257 Query: 309 IIDTNGAGDAFVGGFLSQLV------SDKPLTECIRAGHYAASIIIRRTGC 353 IDT GAGDAFVGG L +L + + + ++ + ++ + G Sbjct: 258 PIDTTGAGDAFVGGLLYRLSVAQDWHNQATILDAVKWANGCGALATTQKGA 308 >3LHX-A nrPDB Length = 319 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/298 (16%), Positives = 96/298 (32%), Gaps = 22/298 (7%) Query: 70 VKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHY 129 K V+ GG T N+ + + +G D F + + +VD Sbjct: 19 EKGADVKRGFGGDTLNTSVYIARQVDPAALTVHYVTALGTDSFSQQMLDAWHGENVDTSL 78 Query: 130 YEQNEQP-TGTCAACITGDNRSLIANLA-AANCYKKEKHLDLEKNWMLVEKARVCYIAGF 187 ++ E G A + Y++G Sbjct: 79 TQRMENRLPGLYYIETDSTGERTFYYWRNEAAAKFWLASEQSAAICEELANFDYLYLSGI 138 Query: 188 FLTV----SPESVLKVAHHASENNRIFTL-NLSAPFISQFYKE---SLMKVMPYVDILFG 239 L + S E +L + N P + +E +++ DI F Sbjct: 139 SLAILSPTSREKLLSLLRECRAKGGKVIFDNNYRPRLWASKEETQQVYQQMLECTDIAFL 198 Query: 240 NETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEV-TA 298 + +Q +D+ + + ++ + V+ +G D +++ E Sbjct: 199 TLDDEDALWGQQ--PVEDV---------IARTHNAGVKEVVVKRGADSCLVSIAGEALVD 247 Query: 299 FAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFP 356 + ++++IDT AGD+F G+L+ ++ + GH AS +I+ G P Sbjct: 248 VPAVKLPKEKVIDTTAAGDSFSAGYLAVRLTGGSAENAAKRGHLTASTVIQYRGAIIP 305 >6CW5-A nrPDB Length = 332 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 57/319 (17%), Positives = 99/319 (31%), Gaps = 27/319 (8%) Query: 54 DQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFG 113 D+ + + + G + VA+ Q G IG D G Sbjct: 24 DEFFHLPHIVRPGETISSTGLTKRAGGKGANQAFAVARAGGQ-----VELDGAIGDD--G 76 Query: 114 EILKRKAAEAHVDAHYYE-QNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKN 172 +K A V + ++ TG D + I A AN Y Sbjct: 77 IWVKEMLESAGVGTDKLKIVKDEVTGRAVIQSAADGENSIVLHAGANYYLP-----SPTP 131 Query: 173 WMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMP 232 + + S + L A +S + ++ +P ++ Sbjct: 132 TTSLATYTHLLVQNEVPLSSTLAYLTAAGQSSPP--LTSVFNPSPMLTPAQLREFP--WK 187 Query: 233 YVDILFGNETEAATFAREQGF-----ETKDIKEIAKK---TQALPKMNSKRQRIVIF-TQ 283 ++ L NE E G E K+ + AK L + + + + I T Sbjct: 188 HLSWLIVNEGELGDLLLAFGSSANPGEAKEDELQAKASAGILELHENDYFSKNVGIICTL 247 Query: 284 GRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYA 343 G + + + + Q + DT GAGD F G F++ L+S K L + ++ A Sbjct: 248 GAKGILCYEPGKEVGYLPAAKLQNPVKDTTGAGDCFAGYFVAGLMSGKSLQDALKTCLVA 307 Query: 344 ASIIIRRTGCTFPEKPDFH 362 I + G P + Sbjct: 308 CGICVENEGA-MESVPTLN 325 >3IQ0-A nrPDB Length = 330 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 98/282 (34%), Gaps = 28/282 (9%) Query: 78 HAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNE-QP 136 + G+ +I + Q + + C+G D FG+I + A VD + Sbjct: 35 YPSGAP--AIFIDQ--VTRLGVPCGIISCVGNDGFGDINIHRLAADGVDIRGISVLPLEA 90 Query: 137 TGTCAACITGDN-RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYI--AGFFLTVSP 193 TG+ R I N+ A C K + +++ +I + F Sbjct: 91 TGSAFVTYHNSGDRDFIFNIKNAACGKLSA---QHVDENILKDCTHFHIMGSSLFSFHMV 147 Query: 194 ESVLKVAHHASENNRI--FTLNLSAPFI-SQFYKESLMKVMPYVDILFGNETEAATFARE 250 ++V K N + F N+ + +++L V+ DI +E E + Sbjct: 148 DAVKKAVTIVKANGGVISFDPNIRKEMLDIPEMRDALHFVLELTDIYMPSEGEVLLLS-- 205 Query: 251 QGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEII 310 + +A+ + + VI +G + +E F V +E+ Sbjct: 206 ---------PHSTPERAIAGFLEEGVKEVIVKRGNQGASYYSANE--QFHVESYPVEEV- 253 Query: 311 DTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 D GAGD F G +++ ++ + ++ + R G Sbjct: 254 DPTGAGDCFGGAWIACRQLGFDAHRALQYANACGALAVTRRG 295 >4DU5-A nrPDB Length = 336 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 111/320 (34%), Gaps = 34/320 (10%) Query: 45 LDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFF 104 LD + +L D+ L E + F + AG T +I +A+ ++ Sbjct: 27 LDVITFGEAMMLLVADRPGPL--EHAEAFH-KRTAGAETNVAIGLARLGLKVGWA----- 78 Query: 105 GCIGIDKFGEILKRKAAEAHVD-AHYYEQNEQPTGTCA-ACITGDNRSLIANLAAANCYK 162 +G D G L A +D +H Q TG +T + + + Sbjct: 79 SRLGTDSMGRYLLAAMAAEGIDCSHVVCDATQKTGFQFKGKVTDGSDPPVEYHRKGSAAS 138 Query: 163 KEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHH------ASENNRIFTLNLSA 216 D+++ W+L AR + G F +S + L A A+ + F NL Sbjct: 139 HMGVADIDEAWLL--SARHLHATGVFPAIS-ATTLPAARKTMDLMRAAGRSVSFDPNLRP 195 Query: 217 PFIS--QFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSK 274 + + ++++ + D + E E E Sbjct: 196 TLWATPELMRDAINDLATRADWVLPGMEEGRFLTGETTPE-----------GVARFYRQL 244 Query: 275 RQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLT 334 ++V+ G + + E + V E++DT GAGD F G +S L+ + Sbjct: 245 GAKLVVVKLGAEGAYF--DGEAGSGRVAGFPVAEVVDTVGAGDGFAVGVISALLDGLGVP 302 Query: 335 ECIRAGHYAASIIIRRTGCT 354 E ++ G + + ++ G + Sbjct: 303 EAVKRGAWIGARAVQVLGDS 322 >4WJM-A nrPDB Length = 312 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 104/310 (33%), Gaps = 36/310 (11%) Query: 63 KELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAE 122 + + + AGGS N+ + + FF I D FG++L+ A Sbjct: 18 MLPRETTGGETAFQPFAGGSVFNT----AIALGRLGVPTGFFSGISSDFFGDVLRDTLAR 73 Query: 123 AHVDAHYYEQNEQPTGTCAA-CITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARV 181 ++VD + + +PT + G R + A + + Sbjct: 74 SNVDYSFAAISNRPTTLAFVRLVDGQARYAFYDENTAGRMLSRNDMPYVDETISAMLFGC 133 Query: 182 CYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKES--LMKVMPYVDILFG 239 + E++L A A N+ A I+ + +++ DI+ Sbjct: 134 ISLISEPCGSVYETLL--AREAPNRVMFLDPNIRANLITVRKTHLTRMKRMIALADIVKL 191 Query: 240 NETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAF 299 ++ + F + EIA + L ++V+ T+G + T Sbjct: 192 SDEDLDWFGEK-----GSHDEIAAEWLKLGP------KLVVITKGAHGAVAYTNHATVPV 240 Query: 300 AVLDQDQKEIIDTNGAGDAFVGGFLSQL-------------VSDKPLTECIRAGHYAASI 346 + D ++DT GAGD G L+ L +S+ + + G AA++ Sbjct: 241 PGVKVD---VVDTVGAGDTVNAGILASLHSQGLLTKDALANLSEDQIHSAVALGVRAAAV 297 Query: 347 IIRRTGCTFP 356 + R G P Sbjct: 298 TVSRAGANPP 307 >1WYE-A nrPDB Length = 311 Score = 95.7 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 100/288 (34%), Gaps = 36/288 (12%) Query: 76 EYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNE- 134 E H GS N + +G D+FG VD + + + Sbjct: 29 EKHVAGSEANYC----VAFIKQGNECGIIAKVGDDEFGYNAIEWLRGQGVDVSHMKIDPS 84 Query: 135 QPTGTCAAC----ITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLT 190 PTG + + S+ +A + +D E V+ A + + +G L Sbjct: 85 APTGIFFIQRHYPVPLKSESIYYRKGSAGSKLSPEDVDEE----YVKSADLVHSSGITLA 140 Query: 191 VS---PESVLKVAHHASENNRIFTLNLSAPFIS-QFYKESLMKVMP--YVDILFGNETEA 244 +S E+V K A +NR F N+ S + K ++K++ ++ L + ++ Sbjct: 141 ISSTAKEAVYKAFEIA--SNRSFDTNIRLKLWSAEEAKREILKLLSKFHLKFLITDTDDS 198 Query: 245 ATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQ 304 E D + AK + I++ G I+ + + + Sbjct: 199 KIILGES-----DPDKAAKAFSDYAE-------IIVMKLGPKGAIVYYDGKKYYSSGYQV 246 Query: 305 DQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 + D GAGDA G FLS + + + A+++ + G Sbjct: 247 PVE---DVTGAGDALGGTFLSLYYKGFEMEKALDYAIVASTLNVMIRG 291 >2AFB-A nrPDB Length = 351 Score = 94.9 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 106/307 (34%), Gaps = 31/307 (10%) Query: 57 LAEDKHKELFDELVKKFKVEYHAGGSTQNSIK-VAQWMIQQPHKAATFFGCIGIDKFGEI 115 L+ HK +F F V Y GG+ N +AQ + A F + + G+ Sbjct: 25 LSPPDHKRIFQT--DSFDVTY--GGAEANVAAFLAQMGL-----DAYFVTKLPNNPLGDA 75 Query: 116 LKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWM- 174 + V Y + G I R A+ E + +W Sbjct: 76 AAGHLRKFGVKTDYIARGGNRIGIYFLEIGASQRPSKVVYDRAHSAISEAK-REDFDWEK 134 Query: 175 LVEKARVCYIAGFFLTVSPESVL---KVAHHASENNRIF--TLNLSAPFI-SQFYKESLM 228 +++ AR + +G + E L A+E LN A + ++ ++ Sbjct: 135 ILDGARWFHFSGITPPLGKELPLILEDALKVANEKGVTVSCDLNYRARLWTKEEAQKVMI 194 Query: 229 KVMPYVDILFGNETEAATFAR--EQGFETKDIKEIAKKTQALPKMNSKRQ--RIVIFTQG 284 M YVD+L NE + +G + K K + + + +++ + V T Sbjct: 195 PFMEYVDVLIANEEDIEKVLGISVEGLDLKTGKLNREAYAKIAEEVTRKYNFKTVGITLR 254 Query: 285 RDDT-------IMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECI 337 + +M E+ F+ ++ + I+D GAGD+F G + + + Sbjct: 255 ESISATVNYWSVMVFENGQPHFS--NRYEIHIVDRVGAGDSFAGALIYGSLMGFDSQKKA 312 Query: 338 RAGHYAA 344 A+ Sbjct: 313 EFAAAAS 319 >3PL2-A nrPDB Length = 319 Score = 94.5 bits (233), Expect = 7e-20, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 94/267 (35%), Gaps = 25/267 (9%) Query: 96 QPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQN---EQPTGTCAACITGDNRSLI 152 + + +G D FGE L + VD Y + + P C D Sbjct: 53 RHGHNSALLSRVGNDPFGEYLLAELERLGVDNQYVATDQTFKTPVTFCEIFPPDDFPLYF 112 Query: 153 ANLAAANCYKKEKHLDLEKNWMLVEKARVCYIA--GFFLTVSPESVLKVAH-HASENNRI 209 A E + + V +A + + GF S + ++ A+ + I Sbjct: 113 YREPKAPDLNIESA---DVSLDDVREADILWFTLTGFSEEPSRGTHREILTTRANRRHTI 169 Query: 210 FTLNLSAPFI--SQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQA 267 F L+ F + + + + + GN+ E E E + +A Sbjct: 170 FDLDYRPMFWESPEEATKQAEWALQHSTVAVGNKEECEIAVGET--------EPERAGRA 221 Query: 268 LPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL 327 L + + + I QG + T+ E D +I+ GAGDAF G L Sbjct: 222 LLE---RGVELAIVKQGPKGVMAMTKDETVEVPPFFVD---VINGLGAGDAFGGALCHGL 275 Query: 328 VSDKPLTECIRAGHYAASIIIRRTGCT 354 +S+ PL + +R + A +++ R C+ Sbjct: 276 LSEWPLEKVLRFANTAGALVASRLECS 302 >3KZH-A nrPDB Length = 328 Score = 91.8 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 43/316 (13%), Positives = 96/316 (30%), Gaps = 26/316 (8%) Query: 44 FLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATF 103 +L + D ++ K+ + G + +A+ + F Sbjct: 8 YLLVFGASVVDVFGFSKASYRPYNSTPGHVKISF-GGVCRNIAENMARVGVN-----TNF 61 Query: 104 FGCIGIDKFGEILKRKAAEAHVDAH-YYEQNEQPTGTCAACITGDNRSLIANLAAANCYK 162 +G D+ G+ + + + T T A + + +++ +A Sbjct: 62 MSILGNDEHGKSIVEHSKKIGYHMDDSMVIEGGSTPTYLAILDENGE-MVSAIADMKSIG 120 Query: 163 KEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQF 222 ++ + E A + + E +LK + F L+ +S Sbjct: 121 AMNTDFIDSKREIFENAEYTVLDSDNPEI-MEYLLKNFK----DKTNFILDP----VSAE 171 Query: 223 YKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFT 282 + ++ + N EA A +T D+ + + L + V + Sbjct: 172 KASWVKHLIKDFHTIKPNRHEAEILAGFPITDTDDLIKASNYFLGL------GIKKVFIS 225 Query: 283 QGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHY 342 D + D K + GAGD+FV G ++ P+ + ++ Sbjct: 226 LDADGIFYNDGVSCGKIKATEVDVKNV---TGAGDSFVAGLGYGYMNKMPIEDIVKFAMT 282 Query: 343 AASIIIRRTGCTFPEK 358 ++I I P+ Sbjct: 283 MSNITISHEETIHPDM 298 >4E69-A nrPDB Length = 328 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 101/305 (33%), Gaps = 28/305 (9%) Query: 68 ELVKKFKVEYHAGGSTQNSIKVAQWMIQ-QPHKAATFFGCIGIDKFGEILKRKAAEAHVD 126 EL + G ++ A ++ + +P ++F IG D + ++ + A +D Sbjct: 35 ELAPADLPGTYRLGFAGDTFNTAWYLARLRPESRISYFSAIGDDALSQQMRAAMSAAGID 94 Query: 127 AHYYEQNEQPT-GTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIA 185 T G + RS A + + E D + + +A V Y + Sbjct: 95 GGGLRVIPGRTVGLYLITLEQGERSF-AYWRGQSAAR-ELAGDADALAAAMARADVVYFS 152 Query: 186 GFFLT----VSPESVLKVAHHASENNRIFTLNLSA-PFISQFYKESLMKVMPYV---DIL 237 G L ++L+ A R + + P + E +M DI Sbjct: 153 GITLAILDQCGRATLLRALAQARATGRTIAFDPNLRPRLWAGTGEMTETIMQGAAVSDIA 212 Query: 238 FGN-ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEV 296 + E EAA F + A + R V+ G + Sbjct: 213 LPSFEDEAAWFG-----------DAGPDATA-DRYARAGVRSVVVKNGPHAVHFLQDGRR 260 Query: 297 TAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFP 356 V +++DT AGD+F G L +++ +PL I A A +++ G Sbjct: 261 G--RVPVPPVAQVVDTTAAGDSFNAGLLDSVLAGQPLETAIAAAAALAGQVVQGKGALV- 317 Query: 357 EKPDF 361 E P Sbjct: 318 EVPSL 322 >3LJS-A nrPDB Length = 338 Score = 85.7 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 46/281 (16%), Positives = 86/281 (30%), Gaps = 39/281 (13%) Query: 96 QPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYY-EQNEQPTGTCAACITGDNRSLIAN 154 + A F G +G D FG+ L AEA V + T + + Sbjct: 48 RLGGAVQFVGMLGSDMFGDFLFDSFAEAGVVTDGIVRTSTAKTALAFVALDAHGERSFSF 107 Query: 155 L--AAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVS--PESVLKVAHHASENNRIF 210 AA+ + +H A + + +T + E + A I Sbjct: 108 YRPPAADLLFRVEHFQD----ASFSDALIFHACSNSMTDADIAEVTFEGMRRAQAAGAIV 163 Query: 211 TLNL-SAPFISQFYK---ESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQ 266 + +L P + + L K + D++ + E A A Sbjct: 164 SFDLNFRPMLWPNGENPASRLWKGLSLADVVKLSSEELDYLANTL---------AADANA 214 Query: 267 ALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQ 326 + ++ R ++++ T T + + ++ D+N AGDAFVGG L Sbjct: 215 VIQQLWQGRAQLLLVTDAAGPVHWYTRTAGGEVPTF---RVQVQDSNAAGDAFVGGMLYT 271 Query: 327 LVSD--------------KPLTECIRAGHYAASIIIRRTGC 353 + + +R ++ + R G Sbjct: 272 FAQQFDDAAALIDFCHDPESIVSTLRFAAAVGALAVTRQGA 312 >2RBC-A nrPDB Length = 343 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 44/265 (16%), Positives = 79/265 (29%), Gaps = 27/265 (10%) Query: 90 AQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQ-NEQPTGTCAACITGDN 148 A + + + A+ +G +G D+ G + R +E+ +D + I Sbjct: 72 AAYAVHRMGGRASLWGAVGDDETGTRILRDLSESGIDTSGMTVAPGARSALSTIIIDNRG 131 Query: 149 RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVS-PESVLKVAHHASENN 207 LI ++K++ E + + V PE L V A Sbjct: 132 ERLIVPFYDHRLHEKKRACTPED---------IALFDAVLVDVRWPELALDVLTVARALG 182 Query: 208 RIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQA 267 + L+ E+L + P + +E A + +K++ A Sbjct: 183 KPAILDGDV-----APVETLEGLAPAATHIVFSEPAATRLTGL-----ETVKDMLPVLHA 232 Query: 268 LPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQL 327 + T G + Q E +DT AGD F G F + Sbjct: 233 RYPQT-----FIAVTAGPAGCWWTEADD-PTVHFQTTMQVEAVDTLAAGDIFHGTFALAM 286 Query: 328 VSDKPLTECIRAGHYAASIIIRRTG 352 +R AA++ G Sbjct: 287 AEGMQSRAAVRLSSVAAALKCTVFG 311 >3NCA-A nrPDB Length = 313 Score = 82.6 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 48/317 (15%), Positives = 96/317 (30%), Gaps = 39/317 (12%) Query: 52 PNDQILAEDKHKELFDELVKKFKVE----------YHAGGSTQNSIKVAQWMIQQPHKAA 101 QIL LV K+ E + GG+ NS V + Sbjct: 17 RGSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTV----LSLLGAPC 72 Query: 102 TFFGCIGIDKFGEILKRKAAEAHVDAH---YYEQNEQPTGTCAACITGDNRSLIANLAAA 158 F G + + L VD + + + P+ C + NR+++ + Sbjct: 73 AFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLH---- 128 Query: 159 NCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNR--IFTLNLSA 216 + + + + + +I G + +K+ +N + Sbjct: 129 -DTSLPDVSATDFEKVDLTQFKWIHIEG----RNASEQVKMLQRIDAHNTRQPPEQKIRV 183 Query: 217 PFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQ 276 + +E L ++ Y D++F ++ A + +E + R+ Sbjct: 184 SVEVEKPREELFQLFGYGDVVFVSKDVAKHLG------FQSAEEALR-----GLYGRVRK 232 Query: 277 RIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTEC 336 V+ ++ A + ++DT GAGD F + L + + E Sbjct: 233 GAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEA 292 Query: 337 IRAGHYAASIIIRRTGC 353 +R G A G Sbjct: 293 LRFGCQVAGKKCGLQGF 309 >3B1N-A nrPDB Length = 326 Score = 82.6 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 88/298 (29%), Gaps = 35/298 (11%) Query: 56 ILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEI 115 IL + H LV + E+ GG N + + A G +G + Sbjct: 25 ILPDQVHLINLSFLVPTMRREF--GGCAGN----IAYALNLLGGDARMMGTLGA-VDAQP 77 Query: 116 LKRKAAEAHVDAHYYEQ-NEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWM 174 + + Y + + DN + A A H K+ Sbjct: 78 YLDRMDALGLSREYVRVLPDTYSAQAMITTDLDNNQITAFHPGAMMQSHVNHAGEAKDIK 137 Query: 175 LVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYV 234 L + GF + +++ ++ F + F +L + + Sbjct: 138 LA----IVGPDGF------QGMVQHTEELAQAGVPFIFDPGQGLPL-FDGATLRRSIELA 186 Query: 235 DILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATES 294 + N+ EA + G+ EIA + QAL I T+G + Sbjct: 187 TYIAVNDYEAKLVCDKTGWSED---EIASRVQAL-----------IITRGEHGATIRHRD 232 Query: 295 EVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG 352 + + +ID G GDAF GG L + R ++ I G Sbjct: 233 GTEQIPAVR--AERVIDPTGCGDAFRGGLLYGIEHGFDWATAGRLASLMGALKIAHQG 288 >2HW1-A nrPDB Length = 298 Score = 82.2 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 85/279 (30%), Gaps = 29/279 (10%) Query: 80 GGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYE-QNEQPTG 138 GG+ NS V + F G + + + VD Y Q Sbjct: 40 GGNASNSCTV----LSLLGAPCAFMGSMAPGHVADFVLDDLRRYSVDLRYTVFQTTGSVP 95 Query: 139 TCAACITGDN--RSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESV 196 I + R+++ + D EK + + + + +I G + Sbjct: 96 IATVIINEASGSRTILYYDRS---LPDVSATDFEK--VDLTQFKWIHIEG----RNASEQ 146 Query: 197 LKVAHHASENNR--IFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFE 254 +K+ +N + + +E L ++ Y D++F ++ A Sbjct: 147 VKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLG------ 200 Query: 255 TKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNG 314 + +E + R+ V+ ++ A + ++DT G Sbjct: 201 FQSAEEALR-----GLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLG 255 Query: 315 AGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGC 353 AGD F + L + + E +R G A G Sbjct: 256 AGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGF 294 >3N1C-A nrPDB Length = 309 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 90/284 (31%), Gaps = 19/284 (6%) Query: 77 YHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQP 136 + GG N VA+ + A F G GE L A+ +V E + Sbjct: 35 FEPGGGGIN---VARAIAHLGGSATAIFPAGG--ATGEHLVSLLADENVPVATVEAKDWT 89 Query: 137 TGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESV 196 + + A + E E+ + A + V E + Sbjct: 90 RQNLHVHVEASGEQYRFVMPGAALNEDEFRQLEEQVLEIESGAILVISGSLPPGVKLEKL 149 Query: 197 LKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETK 256 ++ A + ++ S +S + ++++ N+ E + + + Sbjct: 150 TQLISAAQKQGIRCIVDSSGEALSAAL------AIGNIELVKPNQKELSALVNRELTQPD 203 Query: 257 DIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAG 316 D+++ A++ NS + + V+ + G + + T GAG Sbjct: 204 DVRKAAQEIV-----NSGKAKRVVVSLGPQGALGVDSENCIQV---VPPPVKSQSTVGAG 255 Query: 317 DAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD 360 D+ VG +L + L E +R G A S G D Sbjct: 256 DSMVGAMTLKLAENASLEEMVRFGVAAGSAATLNQGTRLCSHDD 299 >2ABQ-A nrPDB Length = 306 Score = 80.3 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 42/279 (15%), Positives = 86/279 (30%), Gaps = 26/279 (9%) Query: 76 EYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQ 135 GG N +V +++ G +G G ++ + + + E Sbjct: 32 RKQPGGKGINVSRV----LKRLGHETKALGFLGG-FTGAYVRNALEKEEIGLSFIEVEGD 86 Query: 136 PTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPES 195 + + A KKE L + +EK V +AG P++ Sbjct: 87 TR----INVKIKGKQETELNGTAPLIKKEHVQALLEQLTELEKGDVLVLAGSVPQAMPQT 142 Query: 196 V-LKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFE 254 + + A E ++ S + + + N E + + Sbjct: 143 IYRSMTQIAKERGAFVAVDTSGEALHEVLAAKP-------SFIKPNHHELSELVSKPIAS 195 Query: 255 TKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNG 314 +D + ++ + ++ + D + A+ + V + + + G Sbjct: 196 IED------AIPHVQRLIGEGIESILVSFAGDGALFASAEGMFHVNVPSGEVRNSV---G 246 Query: 315 AGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGC 353 AGD+ V GFL+ L K L + + A S G Sbjct: 247 AGDSVVAGFLAALQEGKSLEDAVPFAVAAGSATAFSDGF 285 >3I3Y-A nrPDB Length = 299 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 38/254 (14%), Positives = 69/254 (27%), Gaps = 44/254 (17%) Query: 78 HAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPT 137 G +I ++ + G D G ++++ + Q + Sbjct: 38 IGGKGANQAI-----ILSRCGIETRLIAATGNDSNGAWIRQQIKNEPLMLLPDGHFNQHS 92 Query: 138 GTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVL 197 T + D + I AA + + V + F L + Sbjct: 93 DTSIILNSADGDNAIITTTAAADTFSLDEM-IPHMADAVAGDILLQQGNFSL----DKTR 147 Query: 198 KVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKD 257 + +A N S + P +DI NE+EA Sbjct: 148 ALFQYARSRGMTTVFNPSPVNP------DFCHLWPLIDIAVVNESEAELL---------- 191 Query: 258 IKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGD 317 + ++ TQG + E + + E +DT GAGD Sbjct: 192 --------------QPYGVKTLVITQGAAGAWLVQEGQRQFCPAV---PAEALDTTGAGD 234 Query: 318 AFVGGFLS-QLVSD 330 F+ L+ L+ Sbjct: 235 TFLAVMLASALLRG 248 >6C9R-A nrPDB Length = 337 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 104/320 (32%), Gaps = 31/320 (9%) Query: 36 ISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQ 95 ++ + D L ++ + ++Q+L E HK LV + H GG N + I Sbjct: 18 VTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVD--DLVMHRGGVAGNM----AFAIG 71 Query: 96 QPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITG-DNRSLIAN 154 G G D + V+ + +E C T D + + Sbjct: 72 VLGGEVALVGAAGADF--ADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASF 129 Query: 155 LAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNL 214 A + +++ L + K + I PE++ + F + Sbjct: 130 YPGA--MSEARNIKLADVVSAIGKPELVIIGAN----DPEAMFLHTEECRKLGLAFAADP 183 Query: 215 SAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSK 274 S +++ E + +++ LF N+ E + G+ D+ Sbjct: 184 SQ-QLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADV--------------MA 228 Query: 275 RQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLT 334 + + + T G + T V + D G GDAF GFL+ + L Sbjct: 229 QIDLRVTTLGPKGVDLVEPDG-TTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLE 287 Query: 335 ECIRAGHYAASIIIRRTGCT 354 + G A +++ TG Sbjct: 288 RSAQLGSLVAVLVLESTGTQ 307 >4E84-A nrPDB Length = 352 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 54/360 (15%), Positives = 112/360 (31%), Gaps = 35/360 (9%) Query: 6 EEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKEL 65 + P + L + LRE + VV LD+Y D+I + Sbjct: 25 DIPTTENLYFQGMNTLREVVPVPREQLARSRVLVVGDVMLDRYWFGNVDRI----SPEAP 80 Query: 66 FDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHV 125 + + + E G + VA+ + + A +G D+ GE + + V Sbjct: 81 VPVVHVQRQEERLGG-----AANVARNAVTLGGQ-AGLLCVVGCDEPGERIVELLGSSGV 134 Query: 126 DAHYYEQNEQPTGTCAACITGDNRSLIANLAAA--NCYKKEKHLDLEKNWMLVEKARVCY 183 H PT + + L + A + + +L+ + V Sbjct: 135 TPHLERDPALPTTIKLRVLARQQQLLRVDFEAMPTHEVLLAGLARFD---VLLPQHDVVL 191 Query: 184 IAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETE 243 ++ + V + A + ++ +++ ++ N E Sbjct: 192 MSDYA-KGGLTHVTTMIEKARAAGKAVLVDPKGDDWARY---------RGASLITPNRAE 241 Query: 244 AATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLD 303 + E +A L ++ T+ + + + L Sbjct: 242 LREVVGQWKSEDDLRARVANLRAELD------IDALLLTRSEEGMTLFSAGGELHAPAL- 294 Query: 304 QDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTG-CTFPEKPDFH 362 +E+ D +GAGD + + L + PL + + + AA I++ + G T FH Sbjct: 295 --AREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANRAAGIVVGKLGTATVDYDELFH 352 >3JUL-A nrPDB Length = 320 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 48/285 (16%), Positives = 101/285 (35%), Gaps = 28/285 (9%) Query: 74 KVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQN 133 K E+ GG + V + + G G D ++ E H++ + + Sbjct: 33 KTEFDCGGKGLHVSGV----LSKFGIKNEALGIAGSDNLDKLYA-ILKEKHINHDFLVEA 87 Query: 134 EQPTGTCAACITGD--NRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTV 191 T C ++ D ++I + +L + + ++ V Sbjct: 88 GTSTRECFVVLSDDTNGSTMIPEAGFTVSQTNKDNLLKQIAKKVKKEDMVVIAGSPPPHY 147 Query: 192 SPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQ 251 + ++ + S +++ + V VD + NE E E Sbjct: 148 TLSDFKELLRTVKATGAFLGCDNSGEYLN-------LAVEMGVDFIKPNEDEVIAILDE- 199 Query: 252 GFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIID 311 +T ++E + ++ + G +I A ++ + V+ +E D Sbjct: 200 --KTNSLEENIRTLAEKIPY-------LVVSLGAKGSICAHNGKL--YQVIPPKVQERND 248 Query: 312 TNGAGDAFVGGFLSQLVSDKPLTECIRAGHYA-ASIIIRRTGCTF 355 T GAGD FVG F++ L + P+TE ++ AS ++++ +F Sbjct: 249 T-GAGDVFVGAFIAGLAMNMPITETLKVATGCSASKVMQQDSSSF 292 >4GM6-A nrPDB Length = 351 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 46/289 (15%), Positives = 100/289 (34%), Gaps = 14/289 (4%) Query: 75 VEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNE 134 ++ H GG+ N + V + + + + G++ VD + + Sbjct: 51 LDIHIGGAEAN-VAVN---LSKLGHPTRIATVVPANPIGKMAVEHLWRHQVDTAFVVEAG 106 Query: 135 QPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWM-LVEKARVCYIAGFFLTVS- 192 GT +G + + +H ++ + L++ RV +++G + +S Sbjct: 107 DRLGTY-YLESGTALKAPSVVYDRQHSSFARHKSMDWDLSELLKGIRVLHVSGITIALST 165 Query: 193 --PESVLKVAHHASENNR--IFTLNLSAPFIS-QFYKESLMKVMPYVDILFGNETEAATF 247 E V+K+ A N F +N A + K + +++P VD + +A F Sbjct: 166 FWLEMVVKIIREAKRNGIKISFDMNYRAKLWELEAAKRAYQQLLPLVDYCSAGQMDAVAF 225 Query: 248 AREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQK 307 T + + K + + + + ++ + + Sbjct: 226 FEISSETTDYYQAMHDKYPNIELFY--ATKRTVISASHHLLQGHLWTQGECWESEEYAIY 283 Query: 308 EIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFP 356 I+D G GDA+ L ++S+ E ++ AA + G P Sbjct: 284 PIVDRVGGGDAYTAAVLHGILSEWRPDETVKFATAAAGLKHSIHGDINP 332 >3KTN-A nrPDB Length = 346 Score = 73.0 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 50/323 (15%), Positives = 111/323 (34%), Gaps = 55/323 (17%) Query: 45 LDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHA--GGSTQNSIKVA-QWMIQQPHKAA 101 L + +LA H +L L+ K G + + ++ QW+ ++ Sbjct: 29 LRMNFVGTGVNLLANLAHFQLETALITKLPANRLGEAGKAALRKLGISDQWVGEKGDHIG 88 Query: 102 TFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCY 161 +FF +G G +T NR +A Sbjct: 89 SFFAEMGY----------------------------GIRPTQVTYQNR-----HQSAFGI 115 Query: 162 KKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLN------LS 215 + K D E V+ +C I+ + ++ L +A A + + L+ Sbjct: 116 SEAKDYDFEAFLAEVDMVHICGISLSLTEKTRDAALILAQKAHAYQKKVCFDFNYRPSLN 175 Query: 216 APFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKR 275 + F ++ +++PY DI+FG+ + +D++ A++T+ + + S+ Sbjct: 176 TANSALFMRQQYERILPYCDIVFGSRRDLVELLG--FIPREDLEGEAQETELIQRFMSQY 233 Query: 276 QRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEI-------IDTNGAGDAFVGGFLSQLV 328 G + ++ ++ + + ++ +D GAGDA+ G L Sbjct: 234 NLEWF--AGTTRSHSQNQNYLSGYLYTQNEYQQSEKRPLLNLDRIGAGDAYAAGILYGYS 291 Query: 329 SDKPLTECIRAG--HYAASIIIR 349 + L + + + + I+ Sbjct: 292 QNWSLEKAVTFATVNGVLAHTIQ 314 >3BF5-A nrPDB Length = 306 Score = 67.2 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 52/308 (16%), Positives = 100/308 (32%), Gaps = 55/308 (17%) Query: 44 FLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATF 103 FL + D +++ D VK + + GG+ N VAQ + P Sbjct: 22 FLAYFGHLNIDVLISVDSIPREGSVNVKDLRPRF--GGTAGNFAIVAQK-FRIPF---DL 75 Query: 104 FGCIGIDKFGEILKRKAAEAHVDA-HYYEQNEQPTGTCAACITGDNRSLIANLAAANCYK 162 + +G+ E L ++ H + ++ C G + + A + Sbjct: 76 YSAVGMKTHREYLA-MIESMGINTGHVEKFEDESGPICYIATDGKKQVSFMHQGAMAAWA 134 Query: 163 KEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQF 222 + L ++ + + + + L +A + IF + I ++ Sbjct: 135 PQ----------LADEYEYVHFS------TGPNYLDMAKSIR-SKIIFDPSQE---IHKY 174 Query: 223 YKESLMKV--MPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVI 280 K+ L K + Y+ I N+ E F G S + I Sbjct: 175 SKDELKKFHEISYMSIF--NDHEYRVFREMTGL-------------------SSPKVTTI 213 Query: 281 FTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAG 340 T G + + + + F + DT GAGD+F G L + + + + + G Sbjct: 214 VTNGERGSSLFMDGKKYDFPAIPSSG----DTVGAGDSFRAGLYLALYNRRSIEKGMIYG 269 Query: 341 HYAASIII 348 A +I Sbjct: 270 TIIAHHVI 277 >3GO6-A nrPDB Length = 310 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 72/289 (24%), Gaps = 49/289 (16%) Query: 68 ELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDA 127 E V + GG N + F G G D L+ V Sbjct: 44 ETVLAASLTRTPGGKGANQAV----AAARAGAQVQFSGAFGDDPAAAQLRAHLRANAVGL 99 Query: 128 HYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGF 187 P+GT + + + AN + V V Sbjct: 100 DRTVTVPGPSGTAIIVVDASAENTVLVAPGANAHLTPVP-------SAVANCDVLLTQ-- 150 Query: 188 FLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATF 247 L + + L A A + + +N S + + SL + D++ NE EA Sbjct: 151 -LEIPVATALAAARAAQSADAVVMVNAS---PAGQDRSSLQDLAAIADVVIANEHEA--- 203 Query: 248 AREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQK 307 D + T G V Sbjct: 204 --------NDWPSPPTHF--------------VITLGVRGARYVGADGVFEVPAPT---V 238 Query: 308 EIIDTNGAGDAFVGGFLSQLVS--DKPLT--ECIRAGHYAASIIIRRTG 352 +DT GAGD F G + P +R A ++ +G Sbjct: 239 TPVDTAGAGDVFAGVLAANWPRNPGSPAERLRALRRACAAGALATLVSG 287 >2JG5-A nrPDB Length = 306 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 100/278 (35%), Gaps = 26/278 (9%) Query: 67 DELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVD 126 D L + AGG N +V ++ +T G G G+ + + + Sbjct: 23 DGLNRATATYKFAGGKGINVSRV----LKTLDVESTALGFAGG-FPGKFIIDTLNNSAIQ 77 Query: 127 AHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAG 186 +++ E +E T TG + A + E+ L KN + V Sbjct: 78 SNFIEVDE-DTRINVKLKTGQETEINAPGPHITSTQFEQLLQQIKN--TTSEDIVIVAGS 134 Query: 187 FFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDI-LFGNETEAA 245 ++ ++ ++A ++ A + KE V+PY + + N+ E Sbjct: 135 VPSSIPSDAYAQIAQITAQTG--------AKLVVDAEKELAESVLPYHPLFIKPNKDELE 186 Query: 246 TFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQD 305 ++ K + L K + VI + G D I + E++ AV Sbjct: 187 V---MFNTTVNSDADVIKYGRLLVD---KGAQSVIVSLGGDGAIYIDK-EISIKAV--NP 237 Query: 306 QKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYA 343 Q ++++T G+GD+ V G ++ + S + + + Sbjct: 238 QGKVVNTVGSGDSTVAGMVAGIASGLSIEKAFQQAVAC 275 >2AJR-A nrPDB Length = 331 Score = 59.1 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 64/314 (20%), Positives = 108/314 (34%), Gaps = 30/314 (9%) Query: 53 NDQILAEDKHKELFDELVKKFKVEYHAGGSTQN-SIKVAQWMIQQPHKAATFFGCIGIDK 111 + +I ED + K + GG N SI +++ + P A F G G Sbjct: 24 DREIFIEDFQVNRLYRINDLSKTQMSPGGKGINVSIALSKLGV--PSVATGFVG--GY-- 77 Query: 112 FGEILKRKAAEAH-VDAHYYEQNEQPTGTCAACITGDNRSLIA-NLAAANCYKKEKHLDL 169 G+IL + + + + E T I N+++ A N + + + L Sbjct: 78 MGKILVEELRKISKLITTNFVYVEGETRENIEIIDEKNKTITAINFPGPDVTDMDVNHFL 137 Query: 170 EKNWMLVEKARVCYIAGFFLTVSPESVL-KVAHHASENNRIFTLNLSAPFISQFYKESLM 228 + M + K I+G E + ++ A E +F P + + E Sbjct: 138 RRYKMTLSKVDCVVISGSIPPGVNEGICNELVRLARERG-VFVFVEQTPRLLERIYEGPE 196 Query: 229 KVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDT 288 F N + F D+K + K+ K Q V+ + ++D Sbjct: 197 ---------FPNVVKPDLRGNHASFLGVDLKTFDDYVKLAEKLAEKSQVSVVSYEVKNDI 247 Query: 289 IMATESEVTAFAVLDQDQKEIIDTN---GAGDAFVGGFLSQLVS-DKPLTECIRAGHYAA 344 + E V KE IDT+ GAGDA+V G + + E + G +A Sbjct: 248 VATREG------VWLIRSKEEIDTSHLLGAGDAYVAGMVYYFIKHGANFLEMAKFGFASA 301 Query: 345 SIIIRRTGCTFPEK 358 RR P+ Sbjct: 302 LAATRRKEKYMPDL 315 >4S1M-A nrPDB Length = 287 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 32/179 (17%), Positives = 65/179 (36%), Gaps = 17/179 (9%) Query: 182 CYIAGFFLTVS--PESVLKVAHHASENNRIFTLNLSAPFISQFYK--------ESLMKVM 231 + G+F + E++ +V +N +++ L P + K +S+ +++ Sbjct: 78 FLVTGYFPSSDLVYETINRV-KRIKDNKKVY--FLCDPILGDNGKMYTKSEVQDSMKELI 134 Query: 232 PYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMA 291 Y DI+ N TE + G E + E K L + + +G D ++ Sbjct: 135 KYADIITPNATE---LSFLTGLEVNSVSEAIKACHILHEQGIPVILVTSIKEGNDIILLC 191 Query: 292 T-ESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIR 349 + + + + + D G GD LS ++ PL + I+R Sbjct: 192 SFKDTLNNKNFTIKIPRIEGDFTGVGDTLTYILLSWIIKGIPLEHAVNRAISTLQTILR 250 >5YSQ-A nrPDB Length = 286 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 40/288 (13%), Positives = 89/288 (30%), Gaps = 39/288 (13%) Query: 81 GSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFG--EILKRKAAEAHVDAHYYEQNEQPTG 138 G + V + + G I G + K V + ++ G Sbjct: 6 GHVSKDVNVVDGKREIAYGGGVVMGAITSSLLGVKTKVITKCTREDVSKFSFLRDN---G 62 Query: 139 TCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSP----- 193 + + I N ++ +E L + ++ + +I G + ++P Sbjct: 63 VEVVFLKSPRTTSIENRYGSDPDTRESFLISAADP--FTESDLAFIEGEAVHINPLWYGE 120 Query: 194 --ESVLKVAH-----HASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAAT 246 E ++ V +++ + + + + + E K + Y+D+ + EA T Sbjct: 121 FPEDLIPVLRRKVMFLSADAQGFVRVPENEKLVYRDW-EMKEKYLKYLDLFKVDSREAET 179 Query: 247 FAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTA-FAVLDQD 305 T D++E + ++ +I I+ + A F + Sbjct: 180 LTG-----TNDLRESCRIIRSFGAK-------IILATHASGVIVFDGNFYEASFRSWSLE 227 Query: 306 QKEIIDTNGAGDAFVGGFLSQLV-SDKPLTECIRAGHYAASIIIRRTG 352 + G GD FL V + + + S+ +R G Sbjct: 228 GR-----TGRGDTCTAAFLVGFVFKKMSIEKATKFAAAVTSVKMRHPG 270 >3MBJ-A nrPDB Length = 291 Score = 43.7 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 31/176 (17%), Positives = 61/176 (34%), Gaps = 19/176 (10%) Query: 191 VSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFARE 250 P+S++ +N R++T F + KE + ++ D++ N TE E Sbjct: 103 RQPDSLIVADPVLGDNGRLYT-----NFDMEMVKE-MRHLITKADVITPNLTELFYLLDE 156 Query: 251 QGFETKDIKEIAKKTQALPKMNSKRQRIVIFT------QGRDDTIMATESEVTAFAVLDQ 304 ++ E K+ L ++ K ++VI T + ++ A + + + Sbjct: 157 P-YKADSTDEELKEYLRL--LSDKGPQVVIITSVPVHDEPHKTSVYAYNRQGNRYWKVTC 213 Query: 305 DQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD 360 G GD F L+ L + I++ TF + D Sbjct: 214 PYLPAHYP-GTGDTFTSVITGSLMQGDSLPMALDRAT---QFILQGIRATFGYEYD 265 >2DDM-A nrPDB Length = 283 Score = 42.5 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 43/131 (32%), Gaps = 20/131 (15%) Query: 217 PFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQ 276 P + + Y++ L +P + N E G +D+ ++L K Sbjct: 139 PDLPEAYRQYL---LPLAQGITPNIFELEILT---GKNCRDLDSAIAAAKSLLSDTLK-- 190 Query: 277 RIVIFTQGRDDTIMATESEVTAFAVLDQDQKEII-------DTNGAGDAFVGGFLSQLVS 329 + E++ V+ D +I D G GD F +S L+ Sbjct: 191 --WVVVTSASG---NEENQEMQVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLISGLLK 245 Query: 330 DKPLTECIRAG 340 K LT+ + Sbjct: 246 GKALTDAVHRA 256 >3HYO-A nrPDB Length = 282 Score = 41.8 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 39/121 (32%), Gaps = 3/121 (2%) Query: 221 QFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVI 280 Q Y ++ +++ D++ N TEAA T D++ I QA K + + Sbjct: 122 QDYVAAMRQLIQQADVILPNTTEAALLTGAPYQVTPDLEVILPALQAQLKTGAHAVITDV 181 Query: 281 FTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAG 340 + E+ + + NG GD L PL + Sbjct: 182 QRADQIGCAWLDEAGHVQYCGARRLPGHY---NGTGDTLAAVIAGLLGRGYPLAPTLARA 238 Query: 341 H 341 + Sbjct: 239 N 239 >4JJP-A nrPDB Length = 267 Score = 41.8 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 46/133 (34%), Gaps = 7/133 (5%) Query: 220 SQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIV 279 + + + ++P I+ N EA + D+K + ++ L + V Sbjct: 124 PEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMKRVGEEILQLGP------KFV 177 Query: 280 IFTQGR-DDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIR 338 + G D + F V ++ + +T+G G S L +TE + Sbjct: 178 LMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLALGYEITEAVN 237 Query: 339 AGHYAASIIIRRT 351 + I+R+ Sbjct: 238 LSKIYITEAIKRS 250 >1YGJ-A nrPDB Length = 312 Score = 39.1 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 38/116 (32%), Gaps = 10/116 (8%) Query: 219 ISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPK-------- 270 KV+P DI+ N+ EA + ++ E+ ++ Sbjct: 129 PDDLLPVYREKVVPVADIITPNQFEAELLTGRKIHSQEEALEVMDMLHSMGPDTVVITSS 188 Query: 271 -MNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLS 325 + S R + G T S VT ++ + + + G GD F L+ Sbjct: 189 NLLSPRGSDYLMALGSQRTRAPDGSVVTQRIRMEMHKVDAV-FVGTGDLFAAMLLA 243 >5ZWB-B nrPDB Length = 296 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 36/114 (31%), Gaps = 8/114 (7%) Query: 230 VMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQ--GRDD 287 ++P L N E + G + ++E Q+L K V+ T G Sbjct: 154 LLPQAQGLTPNVFELEMLS---GKPCRTLEEAVAAAQSLLSDTLKW---VVITSAPGESL 207 Query: 288 TIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGH 341 + + + + G GD F +S +V K LT + Sbjct: 208 ETITVAVVTAQVVEVFAHPRVATELKGTGDLFCAELVSGIVQGKKLTTAAKDAA 261 >3ZS7-A nrPDB Length = 300 Score = 38.3 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 34/236 (14%), Positives = 67/236 (28%), Gaps = 37/236 (15%) Query: 138 GTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWM--LVEKARVCYIAGFFLTVSP-- 193 G C++ N S + +E +E + R + G+ V Sbjct: 36 GINTVCLS--NHSGYPVIRGHRMSLQEYDELMEGVRANNFLSNYR-YILTGYINNVDIIG 92 Query: 194 --ESVLKVAHHASENNRIFTLNLSAP--------FISQFYKESLMKVMPYVDILFGNETE 243 LK E + P + + ++ +++P DI+ N E Sbjct: 93 RIRDTLKEVRELREKEDKKLTFICDPVMGDDGIMYCKKEVLDAYRELVPLADIVTPNYFE 152 Query: 244 AATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRD-----------DTIMAT 292 A+ + + +++ A ++ VI R+ + Sbjct: 153 ASLLSGV------TVNDLSSAILAADWFHNCGVAHVIIKSFREQENPTHLRFLYSVKEGS 206 Query: 293 ESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIII 348 E+ V F+ + + G GD F L P+ I +I Sbjct: 207 EAAVRRFSGVVPYHEGRY--TGTGDVFAACLL-AFSHSHPMDVAIGKSMAVLQELI 259 >2F7K-A nrPDB Length = 327 Score = 38.3 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 43/121 (35%), Gaps = 20/121 (16%) Query: 219 ISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRI 278 KV+P DI+ N+ EA + + I + + + ++S Sbjct: 144 PEDLLPVYKEKVVPLADIITPNQFEAELLSG------RKIHSQEEALRVMDMLHSMGPDT 197 Query: 279 VIFT-------QGRDDTIM--ATESEVTAFAVLDQDQK---EIIDT--NGAGDAFVGGFL 324 V+ T QG + I+ + A +V+ + + +D G GD F L Sbjct: 198 VVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLL 257 Query: 325 S 325 + Sbjct: 258 A 258 >1JXH-A nrPDB Length = 288 Score = 36.4 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 40/238 (16%), Positives = 72/238 (30%), Gaps = 31/238 (13%) Query: 148 NRSLIANLAAANCYKKEKHLDLEKNWM------LVEKARV--CYIAGFFLTVSPESVLKV 199 S+I L A N + +E +++ + R+ I T E+V + Sbjct: 56 GCSVITALVAENTCGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAER 115 Query: 200 AHHASENNRIFTLNL----SAPFISQFYKESLM-KVMPYVDILFGNETEAATFAREQGFE 254 N + + P +S E+L +++P V ++ N EAA Sbjct: 116 LQRHHVRNVVLDTVMLAKSGDPLLSPSAIETLRVRLLPQVSLITPNLPEAAALLDAPHAR 175 Query: 255 TKDIKEIAKKTQALPKMNSKRQRIVIFTQGR-----DDTIMATESEVTAFAVLDQDQKEI 309 T+ +E+ + +AL M V+ G + T F+ + K Sbjct: 176 TE--QEMLAQGRALLAMGC---EAVLMKGGHLEDAQSPDWLFTREGEQRFSAPRVNTKN- 229 Query: 310 IDTNGAGDAFVGGFLS----QLVSDKPLTEC-IRAGHYAASIIIRRTGCTFPEKPDFH 362 T+G G + + + E A G FH Sbjct: 230 --THGTGCTLSAALAALRPRHRSWGETVNEAKAWLSAALAQADTLEVGKGIGPVHHFH 285 >4C5N-A nrPDB Length = 276 Score = 36.4 bits (82), Expect = 0.021, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 41/128 (32%), Gaps = 8/128 (6%) Query: 224 KESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQ 283 + + ++P ++ N EA + I +A + K + VI Sbjct: 123 EAMIKYLLPKATVVTPNLFEAGQLSGLGKLN-----SIEDMKKAATIIFDKGAQHVIIKG 177 Query: 284 GR---DDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAG 340 G+ D + F L D + +GAG F + L + K E + + Sbjct: 178 GKALDQDKSYDLYYDGQTFYQLTTDMFQQSYNHGAGCTFAAATTAYLANGKSPKEAVISA 237 Query: 341 HYAASIII 348 + I Sbjct: 238 KAFVASAI 245 >5B6A-A nrPDB Length = 288 Score = 35.2 bits (79), Expect = 0.043, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 42/128 (32%), Gaps = 3/128 (2%) Query: 216 APFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKR 275 AP +S F L + D L N+ E +F Q D E+A+ A Sbjct: 127 APEVSDFL---LEEAAAVADYLCPNQLELDSFCDRQPNSLADCVEMARSLLARGPRAILV 183 Query: 276 QRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTE 335 + + + D M + A+ + G GD G FLS+L+ L Sbjct: 184 KHLNYPGKAGDTFEMLLVAADQAWHLQRPLLAFPRQPVGVGDLASGLFLSRLLLGDDLRN 243 Query: 336 CIRAGHYA 343 A Sbjct: 244 AFEFTGAA 251 >1UB0-A nrPDB Length = 258 Score = 34.8 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 48/139 (34%), Gaps = 18/139 (12%) Query: 229 KVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFT----QG 284 ++ P D++ N EA I+ + + +A + + + V+ +G Sbjct: 126 RLFPLADLVTPNRLEAEALLGRP------IRTLKEAEEAAKALLALGPKAVLLKGGHLEG 179 Query: 285 RDDT-IMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYA 343 + ++AT V F+ + T+G G + L +PL E + Sbjct: 180 EEAVDLLATRGGVLRFSAPRVHTRN---THGTGCTLSAAIAALLAKGRPLAEAV----AE 232 Query: 344 ASIIIRRTGCTFPEKPDFH 362 A + R T P H Sbjct: 233 AKAYLTRALKTAPSLGHGH 251 >4XF7-A nrPDB Length = 273 Score = 34.8 bits (78), Expect = 0.059, Method: Composition-based stats. Identities = 15/108 (13%), Positives = 33/108 (30%), Gaps = 4/108 (3%) Query: 239 GNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTA 298 E + K + + Q L + + +++ + G + Sbjct: 144 PGEIQYQPIDGSFLKGVKILHADLGEYQYLQGFSPEFVDVLLLSNGPEPGKAFLHGREYT 203 Query: 299 FAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASI 346 F + E + GAGD F+G F P + ++ ++ Sbjct: 204 FEPVHVGVDE---STGAGDVFLGAFTGFYSQ-CPFVQALKRAAAFTAL 247 >5TRW-A nrPDB Length = 296 Score = 34.4 bits (77), Expect = 0.077, Method: Composition-based stats. Identities = 23/135 (17%), Positives = 43/135 (31%), Gaps = 7/135 (5%) Query: 221 QFYKESLMKVMPYV-DILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIV 279 +E L++ MP V D + N TE R G E + ++E + L K + Sbjct: 133 PGIQEFLVRTMPGVADAMAPNHTE---LQRLVGREIETLEEAVTACRELIARGPKLVLVK 189 Query: 280 IFTQGRDDTIMATE---SEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTEC 336 +E A+ G GD F+++ + + Sbjct: 190 HLLDRNSPADRFNMLVVTEREAWMGQRPLYPFARQPVGVGDLTSAVFVARTLLGDSIRAA 249 Query: 337 IRAGHYAASIIIRRT 351 A + +++ T Sbjct: 250 FEHTLAAVNAVVKAT 264 >5GJQ-a nrPDB Length = 239 Score = 34.4 bits (77), Expect = 0.085, Method: Composition-based stats. Identities = 13/98 (13%), Positives = 35/98 (35%), Gaps = 4/98 (4%) Query: 258 IKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGD 317 + A + + + I G D +V + + ++ G+G Sbjct: 110 VHTAASLFKEMCYRYREDLMAGIIIAGWDP---QEGGQVYSVPMGGMMVRQSFAIGGSGS 166 Query: 318 AFVGGFL-SQLVSDKPLTECIRAGHYAASIIIRRTGCT 354 +++ G++ + EC++ A ++ + R G + Sbjct: 167 SYIYGYVDATYREGMTKEECLQFTANALALAMERDGSS 204 >5LEZ-N nrPDB Length = 205 Score = 34.1 bits (76), Expect = 0.099, Method: Composition-based stats. Identities = 13/98 (13%), Positives = 35/98 (35%), Gaps = 4/98 (4%) Query: 258 IKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGD 317 + A + + + I G D +V + + ++ G+G Sbjct: 76 VHTAASLFKEMCYRYREDLMAGIIIAGWDP---QEGGQVYSVPMGGMMVRQSFAIGGSGS 132 Query: 318 AFVGGFL-SQLVSDKPLTECIRAGHYAASIIIRRTGCT 354 +++ G++ + EC++ A ++ + R G + Sbjct: 133 SYIYGYVDATYREGMTKEECLQFTANALALAMERDGSS 170 >6AVO-A nrPDB Length = 199 Score = 32.9 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 19/42 (45%), Gaps = 1/42 (2%) Query: 314 GAGDAFVGGFL-SQLVSDKPLTECIRAGHYAASIIIRRTGCT 354 G+G F+ G++ + EC R A ++ + R G + Sbjct: 128 GSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSS 169 >6EPC-1 nrPDB Length = 238 Score = 32.9 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 13/98 (13%), Positives = 35/98 (35%), Gaps = 4/98 (4%) Query: 258 IKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGD 317 + A + + + I G D +V + + ++ G+G Sbjct: 109 VHTAASLFKEMCYRYREDLMAGIIIAGWDP---QEGGQVYSVPMGGMMVRQSFAIGGSGS 165 Query: 318 AFVGGFL-SQLVSDKPLTECIRAGHYAASIIIRRTGCT 354 +++ G++ + EC++ A ++ + R G + Sbjct: 166 SYIYGYVDATYREGMTKDECLQFTANALALAMERDGSS 203 >2QEQ-A nrPDB Length = 434 Score = 32.5 bits (72), Expect = 0.33, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 36/92 (39%), Gaps = 8/92 (8%) Query: 255 TKDIKEIAKKTQALPKMNS-KRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTN 313 T DI E+ +A ++S K + I T+G I+ S VTA + + + + + Sbjct: 223 TTDISEMGANFKASRVIDSRKSVKPTIITEGEGRVILGEPSAVTAASAAQRRGRTGRNPS 282 Query: 314 GAGDAFVGGFLSQLVSDKPLTECIRAGHYAAS 345 AGD + G + H+ + Sbjct: 283 QAGDEYCYG-------GHTNEDDSNCAHWTEA 307 >1POI-B nrPDB Length = 260 Score = 32.1 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 28/60 (46%) Query: 177 EKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDI 236 EK + Y+A ++ T SPE VL+ + ++ L P + + +E + ++ + Sbjct: 200 EKTKRMYLAAYYPTSSPEDVLENTGFDLDVSKAVELEAPDPAVIKLIREEIDPGQAFIQV 259 >4FOI-A nrPDB Length = 917 Score = 31.4 bits (69), Expect = 0.69, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 58/174 (33%), Gaps = 21/174 (12%) Query: 23 ENILFGMGNPLLDISAVVDKDFLDKYSLK----PNDQILAEDKHKELFDE--LVKKFKVE 76 ENI+ G G+ L D A DF++K +K P + + DE L+ K Sbjct: 116 ENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRF 175 Query: 77 YHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQP 136 +G + +K+ I++ + D G ++ + H + Sbjct: 176 KASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLII----G 231 Query: 137 TGTCAA---------CITGDNRSLIAN--LAAANCYKKEKHLDLEKNWMLVEKA 179 TGT A + GD + N A + + E + + + Sbjct: 232 TGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGS 285 >5LJ5-t nrPDB Length = 503 Score = 29.8 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 23/56 (41%) Query: 130 YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIA 185 Y E TGT I +++IA +N K KNW E++ +C + Sbjct: 414 YTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQS 469 >4ZB4-A nrPDB Length = 360 Score = 29.8 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 23/56 (41%) Query: 130 YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIA 185 Y E TGT I +++IA +N K KNW E++ +C + Sbjct: 271 YTIPEFKTGTVTYDIDDSGKNMIAYSNESNSLTIYKFDKKTKNWTKDEESALCLQS 326 >5TQI-A nrPDB Length = 294 Score = 28.7 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 35/128 (27%), Gaps = 6/128 (4%) Query: 227 LMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRD 286 + ++ D + N TE A G + + E + L K + Sbjct: 139 VNEMPALADGMSPNHTELQKLA---GRRIETVAEAVDACRTLIARGPKIILVKHLHDRNS 195 Query: 287 DTIMATE---SEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYA 343 +E A+ G GD F+++ + + A Sbjct: 196 PADRFNMLAVTETEAWIGQRPLYAFPRHPVGVGDLTSAIFVARRLRGDSVRAAFEHTLAA 255 Query: 344 ASIIIRRT 351 +++ T Sbjct: 256 VHAVVKAT 263 >1V59-A nrPDB Length = 478 Score = 28.7 bits (62), Expect = 4.7, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 21/33 (63%) Query: 283 QGRDDTIMATESEVTAFAVLDQDQKEIIDTNGA 315 + I+AT SEVT F ++ D+++I+ + GA Sbjct: 144 LDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 176 >4PXL-B nrPDB Length = 517 Score = 28.7 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 32/171 (18%), Positives = 53/171 (30%), Gaps = 28/171 (16%) Query: 70 VKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHY 129 V + G VA H G + G ++ R AAE+++ Sbjct: 229 VPAGVLNVVPGFGPTAGAAVAA------HMDVDKVSFTGSTEVGRLVMRAAAESNLKP-- 280 Query: 130 YEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLE----KNWMLVEKARVCYIA 185 + +S + A+ ++ K + V R+ Sbjct: 281 ------------VSLELGGKSPVIVFDDADLDMAVNLVNFATYTNKGEICVAGTRIYVQE 328 Query: 186 GFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDI 236 G + E V K A AS++ N S Q K+ KV+ Y+DI Sbjct: 329 GIYD----EFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKVLRYIDI 375 >3X1F-A nrPDB Length = 352 Score = 27.9 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 12/28 (42%) Query: 293 ESEVTAFAVLDQDQKEIIDTNGAGDAFV 320 ++ V ++ V + D N GD F Sbjct: 216 QNGVPSYVVFSSKALKPGDPNTNGDTFT 243 >3WIA-A nrPDB Length = 287 Score = 27.9 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 12/28 (42%) Query: 293 ESEVTAFAVLDQDQKEIIDTNGAGDAFV 320 ++ V ++ V + D N GD F Sbjct: 151 QNGVPSYVVFSSKALKPGDPNTNGDTFT 178 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.118 0.275 Lambda K H 0.267 0.0363 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 10,917,636 Number of Sequences: 36641 Number of extensions: 379228 Number of successful extensions: 1409 Number of sequences better than 10.0: 86 Number of HSP's better than 10.0 without gapping: 104 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 1175 Number of HSP's gapped (non-prelim): 145 length of query: 362 length of database: 10,336,785 effective HSP length: 98 effective length of query: 264 effective length of database: 6,745,967 effective search space: 1780935288 effective search space used: 1780935288 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.5 bits)