BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P54646 (552 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4CFF-A nrPDB 1151 0.0 5EZV-A nrPDB 1079 0.0 4REW-A nrPDB 848 0.0 4CFH-A nrPDB 815 0.0 4RED-A nrPDB 623 e-179 2YZA-A nrPDB 573 e-164 3H4J-B nrPDB 359 2e-99 3MN3-A nrPDB 359 2e-99 4CZT-A nrPDB 280 1e-75 4YNZ-A nrPDB 273 2e-73 5KZ7-A nrPDB 270 1e-72 2QNJ-A nrPDB 270 2e-72 6C9D-A nrPDB 263 1e-70 2HAK-A nrPDB 262 4e-70 5ES1-A nrPDB 261 4e-70 4D28-A nrPDB 256 2e-68 4CQG-A nrPDB 244 7e-65 4D2V-A nrPDB 241 9e-64 5YKS-A nrPDB 224 6e-59 5WAX-A nrPDB 204 8e-53 3UDB-A nrPDB 202 3e-52 3ZUT-A nrPDB 200 2e-51 3UC3-A nrPDB 191 7e-49 3F3Z-A nrPDB 188 6e-48 2JC6-A nrPDB 183 2e-46 2Y8Q-A nrPDB 183 2e-46 5JN2-A nrPDB 182 2e-46 4FG9-A nrPDB 180 1e-45 3MA6-A nrPDB 177 8e-45 2JAM-A nrPDB 176 3e-44 4RGJ-A nrPDB 175 6e-44 3NCG-A nrPDB 174 7e-44 4MVF-A nrPDB 174 1e-43 5IG1-A nrPDB 173 2e-43 3DFA-A nrPDB 172 4e-43 2BDW-A nrPDB 171 1e-42 5XZW-A nrPDB 171 1e-42 3BHH-A nrPDB 170 1e-42 3KK8-A nrPDB 170 2e-42 2Y7J-A nrPDB 169 2e-42 5FG8-A nrPDB 169 2e-42 2YCR-A nrPDB 169 3e-42 4PDS-A nrPDB 169 4e-42 3HZT-A nrPDB 168 4e-42 3DXN-A nrPDB 168 5e-42 2VN9-A nrPDB 168 6e-42 4YZB-A nrPDB 167 7e-42 5U6Y-A nrPDB 167 1e-41 3I6U-A nrPDB 167 1e-41 2VZ6-A nrPDB 167 2e-41 2W4O-A nrPDB 166 2e-41 5X3F-B nrPDB 166 3e-41 4WB7-A nrPDB 165 4e-41 3LIJ-A nrPDB 164 8e-41 5N23-A nrPDB 164 1e-40 3SOA-A nrPDB 162 3e-40 5JZN-A nrPDB 162 3e-40 1FOT-A nrPDB 162 4e-40 2V7O-A nrPDB 162 4e-40 3Q5I-A nrPDB 161 6e-40 2JDO-A nrPDB 161 9e-40 3TXO-A nrPDB 159 2e-39 3MV5-A nrPDB 159 4e-39 5KCV-A nrPDB 158 6e-39 2BRG-A nrPDB 157 1e-38 5FET-A nrPDB 156 2e-38 2J90-A nrPDB 155 4e-38 4B8L-A nrPDB 154 7e-38 5DYK-A nrPDB 154 8e-38 5LOH-A nrPDB 154 1e-37 4UZD-A nrPDB 154 1e-37 1PHK-A nrPDB 153 1e-37 3D2K-A nrPDB 153 2e-37 3GUB-A nrPDB 153 2e-37 2WTK-C nrPDB 152 5e-37 4JXF-A nrPDB 151 8e-37 4RA4-A nrPDB 149 3e-36 5F9E-A nrPDB 147 1e-35 6CMJ-A nrPDB 146 2e-35 2YAB-A nrPDB 145 4e-35 3IS5-A nrPDB 145 6e-35 3KN6-A nrPDB 143 1e-34 4I6B-A nrPDB 141 7e-34 6FDY-U nrPDB 141 9e-34 5YV8-A nrPDB 141 9e-34 2A27-A nrPDB 140 1e-33 1ZWS-A nrPDB 140 2e-33 2OU7-A nrPDB 139 4e-33 3TAC-A nrPDB 139 4e-33 3PFQ-A nrPDB 139 4e-33 6BDL-A nrPDB 138 6e-33 4C0T-A nrPDB 138 6e-33 2I0E-A nrPDB 138 6e-33 4J52-A nrPDB 137 9e-33 4B6L-A nrPDB 137 2e-32 4AF3-A nrPDB 136 2e-32 3DB8-A nrPDB 136 3e-32 3DLS-A nrPDB 135 3e-32 4NIF-A nrPDB 135 4e-32 6QAU-A nrPDB 132 3e-31 3HDN-A nrPDB 131 8e-31 1KOA-A nrPDB 131 8e-31 3UTO-A nrPDB 131 8e-31 1NY3-A nrPDB 131 9e-31 2OZA-A nrPDB 130 1e-30 4EAL-A nrPDB 130 2e-30 2X4F-A nrPDB 129 3e-30 2Z7Q-A nrPDB 129 3e-30 4WNO-A nrPDB 129 3e-30 5D9K-A nrPDB 129 4e-30 4FR4-A nrPDB 128 7e-30 3KA0-A nrPDB 128 7e-30 1KOB-A nrPDB 128 8e-30 6CCF-A nrPDB 127 2e-29 3ORZ-A nrPDB 126 3e-29 4JG6-A nrPDB 125 3e-29 3LM0-A nrPDB 125 4e-29 3FXW-A nrPDB 125 5e-29 3A8W-A nrPDB 125 5e-29 4X7Q-B nrPDB 125 6e-29 2XNP-A nrPDB 122 3e-28 6E9W-A nrPDB 122 4e-28 5TUR-A nrPDB 122 5e-28 4L42-A nrPDB 120 1e-27 6ED6-A nrPDB 120 2e-27 3BGP-A nrPDB 119 2e-27 4RC3-A nrPDB 119 3e-27 4RLP-A nrPDB 119 4e-27 1VZO-A nrPDB 119 4e-27 4EQM-A nrPDB 118 6e-27 6FD3-A nrPDB 117 1e-26 5CEK-A nrPDB 117 1e-26 6DC0-A nrPDB 117 2e-26 4KS7-A nrPDB 117 2e-26 3HKO-A nrPDB 116 2e-26 3PPZ-A nrPDB 115 4e-26 6CKI-A nrPDB 115 5e-26 3Q53-A nrPDB 114 9e-26 2F57-A nrPDB 113 2e-25 2HW6-A nrPDB 113 2e-25 4FIE-A nrPDB 113 3e-25 4XBR-A nrPDB 112 3e-25 2Q0N-A nrPDB 112 5e-25 4JDH-A nrPDB 112 5e-25 3ZDU-A nrPDB 112 5e-25 4CRS-A nrPDB 112 5e-25 4QMW-A nrPDB 110 1e-24 2BPM-A nrPDB 110 2e-24 4APC-A nrPDB 110 2e-24 2XIK-A nrPDB 109 3e-24 4OTD-A nrPDB 108 4e-24 3M42-A nrPDB 108 6e-24 3COM-A nrPDB 108 7e-24 4AW2-A nrPDB 108 8e-24 6BXI-A nrPDB 107 2e-23 3TKU-A nrPDB 107 2e-23 5L2Q-C nrPDB 106 2e-23 1V0B-A nrPDB 105 4e-23 4AGU-A nrPDB 105 7e-23 4FZF-B nrPDB 104 9e-23 5DBX-A nrPDB 103 2e-22 3DAK-A nrPDB 103 2e-22 3ORP-A nrPDB 103 2e-22 3QA8-A nrPDB 102 6e-22 4LG4-A nrPDB 101 8e-22 3NYO-A nrPDB 101 8e-22 6AO5-A nrPDB 101 8e-22 6GU6-A nrPDB 101 9e-22 2VD5-A nrPDB 101 9e-22 5G6V-A nrPDB 101 1e-21 4KRC-A nrPDB 100 1e-21 4TNB-A nrPDB 100 2e-21 1TKI-A nrPDB 100 2e-21 3SXS-A nrPDB 99 5e-21 5VO2-A nrPDB 98 7e-21 4CSV-A nrPDB 98 1e-20 4BBM-A nrPDB 97 1e-20 5EFQ-A nrPDB 97 2e-20 2A1A-B nrPDB 96 3e-20 4KIK-B nrPDB 96 5e-20 3UIU-A nrPDB 95 9e-20 2DQ7-X nrPDB 94 1e-19 3A4O-X nrPDB 94 1e-19 2H8H-A nrPDB 94 2e-19 5D7A-A nrPDB 94 2e-19 5X5O-A nrPDB 94 2e-19 6CQF-A nrPDB 94 2e-19 1ZXE-A nrPDB 93 2e-19 2W96-B nrPDB 93 3e-19 5O0Y-A nrPDB 93 3e-19 5UUU-A nrPDB 93 4e-19 1CM8-A nrPDB 92 5e-19 3PVW-A nrPDB 92 6e-19 6DTL-A nrPDB 92 6e-19 3NIZ-A nrPDB 92 7e-19 4U41-A nrPDB 92 7e-19 3GC0-A nrPDB 91 9e-19 4NST-A nrPDB 91 1e-18 5SYS-A nrPDB 91 1e-18 4X3F-A nrPDB 91 1e-18 4E93-A nrPDB 91 1e-18 4OW8-A nrPDB 91 1e-18 3OHT-A nrPDB 91 1e-18 6F3F-A nrPDB 91 2e-18 2XYN-A nrPDB 91 2e-18 6E2O-A nrPDB 91 2e-18 4EBW-A nrPDB 90 2e-18 5H2U-A nrPDB 90 3e-18 6B2Q-A nrPDB 90 3e-18 5HI2-A nrPDB 90 3e-18 4AN9-A nrPDB 89 3e-18 2J0K-A nrPDB 89 4e-18 2WQN-A nrPDB 89 4e-18 3C51-A nrPDB 89 4e-18 5KKR-C nrPDB 89 6e-18 6CTH-A nrPDB 89 6e-18 5B2L-A nrPDB 89 7e-18 2F9G-A nrPDB 89 7e-18 5TQX-A nrPDB 89 7e-18 5HVK-A nrPDB 88 8e-18 4XEY-B nrPDB 88 8e-18 4EWQ-A nrPDB 88 9e-18 5HIE-A nrPDB 88 1e-17 6NPU-A nrPDB 88 1e-17 3EQC-A nrPDB 87 1e-17 2FO0-A nrPDB 87 2e-17 4HVI-A nrPDB 87 2e-17 1G3N-A nrPDB 87 2e-17 4IC8-A nrPDB 87 3e-17 3V5Q-A nrPDB 86 3e-17 1S9I-A nrPDB 86 4e-17 2Y6O-A nrPDB 86 4e-17 4ZSG-A nrPDB 86 5e-17 2PL0-A nrPDB 86 5e-17 4PDO-A nrPDB 86 6e-17 3MIA-A nrPDB 86 6e-17 3GC9-A nrPDB 86 6e-17 4JLC-A nrPDB 85 6e-17 4MYG-A nrPDB 85 7e-17 4AU8-A nrPDB 85 8e-17 5J5T-A nrPDB 85 9e-17 2HK5-A nrPDB 85 9e-17 4Y83-A nrPDB 85 1e-16 2PMN-X nrPDB 85 1e-16 4AT3-A nrPDB 84 1e-16 1U59-A nrPDB 84 2e-16 4UY9-A nrPDB 84 2e-16 5AMN-A nrPDB 84 2e-16 4P5Q-A nrPDB 84 2e-16 6NT9-A nrPDB 84 2e-16 4BGQ-A nrPDB 84 2e-16 3DTC-A nrPDB 83 2e-16 2UV2-A nrPDB 83 2e-16 3DKO-A nrPDB 83 3e-16 3E7O-A nrPDB 83 3e-16 4EUU-A nrPDB 83 3e-16 4UYA-A nrPDB 83 3e-16 4EUT-A nrPDB 83 3e-16 4YFF-A nrPDB 83 3e-16 5UIU-A nrPDB 83 3e-16 3QGY-A nrPDB 83 4e-16 3OZ6-A nrPDB 83 4e-16 2W1I-A nrPDB 83 4e-16 2OZO-A nrPDB 83 4e-16 5O2C-A nrPDB 83 4e-16 4QNY-A nrPDB 82 4e-16 1UA2-A nrPDB 82 4e-16 6O8B-A nrPDB 82 5e-16 4GS6-A nrPDB 82 5e-16 3IO7-A nrPDB 82 5e-16 4YHJ-A nrPDB 82 6e-16 2R2P-A nrPDB 82 7e-16 5O2B-A nrPDB 82 7e-16 4XI2-A nrPDB 82 8e-16 5A46-A nrPDB 82 8e-16 6DBM-A nrPDB 82 8e-16 4NEU-A nrPDB 82 9e-16 6E4F-A nrPDB 82 9e-16 3QUP-A nrPDB 81 9e-16 5AWM-A nrPDB 81 9e-16 4Y93-A nrPDB 81 1e-15 3KUL-B nrPDB 81 1e-15 3GQL-A nrPDB 80 2e-15 6HXF-B nrPDB 80 2e-15 5FM2-A nrPDB 80 2e-15 6DBN-A nrPDB 80 2e-15 4TPT-A nrPDB 80 2e-15 4OLI-A nrPDB 80 2e-15 5NGU-A nrPDB 80 3e-15 3TT0-A nrPDB 80 3e-15 4E20-A nrPDB 80 3e-15 4PWN-A nrPDB 79 4e-15 1K9A-A nrPDB 79 4e-15 2VWV-A nrPDB 79 5e-15 4M7I-A nrPDB 79 6e-15 5Y86-A nrPDB 79 6e-15 3OMV-A nrPDB 79 7e-15 6J5U-C nrPDB 78 8e-15 3ALO-A nrPDB 78 8e-15 1U5R-A nrPDB 78 8e-15 4LQP-A nrPDB 78 1e-14 2XS0-A nrPDB 78 1e-14 4IDT-A nrPDB 78 1e-14 2GCD-A nrPDB 78 1e-14 4H1J-A nrPDB 77 1e-14 1BYG-A nrPDB 77 2e-14 4QTB-A nrPDB 77 2e-14 6GVJ-A nrPDB 77 2e-14 3HMP-A nrPDB 77 2e-14 1AD5-A nrPDB 77 2e-14 2ZMD-A nrPDB 77 2e-14 2H34-A nrPDB 77 2e-14 4C59-A nrPDB 77 3e-14 5Z33-A nrPDB 76 3e-14 1JNK-A nrPDB 76 4e-14 5KMM-A nrPDB 76 4e-14 4F0G-A nrPDB 76 4e-14 5AP3-A nrPDB 76 5e-14 3BBT-B nrPDB 76 5e-14 1JPA-A nrPDB 75 5e-14 3E3P-A nrPDB 75 6e-14 3UIM-A nrPDB 75 6e-14 2PSQ-A nrPDB 75 7e-14 3N9X-A nrPDB 75 7e-14 2JD5-A nrPDB 75 7e-14 2WTK-B nrPDB 75 8e-14 5EG3-A nrPDB 75 9e-14 5XVU-A nrPDB 74 1e-13 3FI2-A nrPDB 74 2e-13 5IKW-A nrPDB 73 3e-13 3VN9-A nrPDB 73 3e-13 5L6P-A nrPDB 73 3e-13 6O6Q-A nrPDB 73 4e-13 4E7W-A nrPDB 72 4e-13 3BEA-A nrPDB 72 5e-13 4M66-A nrPDB 72 5e-13 5TOS-A nrPDB 72 6e-13 5ZTN-A nrPDB 72 7e-13 4HZS-A nrPDB 72 7e-13 3FME-A nrPDB 72 7e-13 5X8I-B nrPDB 72 7e-13 3KRL-A nrPDB 72 7e-13 1U54-B nrPDB 72 8e-13 5MJB-A nrPDB 72 8e-13 4XCU-A nrPDB 72 8e-13 4LFI-A nrPDB 72 9e-13 4G3E-A nrPDB 71 1e-12 5U6B-A nrPDB 71 1e-12 5AIR-A nrPDB 71 1e-12 2OGV-A nrPDB 71 2e-12 5WNL-A nrPDB 70 2e-12 3PLS-A nrPDB 70 2e-12 6EII-A nrPDB 70 2e-12 6HV0-A nrPDB 70 2e-12 6FYV-A nrPDB 70 3e-12 5GRN-A nrPDB 70 3e-12 4MD7-E nrPDB 70 3e-12 1FVR-A nrPDB 69 4e-12 2RIO-A nrPDB 69 4e-12 4K33-A nrPDB 69 4e-12 3LMG-A nrPDB 69 5e-12 3ZZW-A nrPDB 69 5e-12 5C26-A nrPDB 69 5e-12 4FL3-A nrPDB 69 5e-12 5TE0-A nrPDB 69 5e-12 2QKW-B nrPDB 69 6e-12 5VD3-A nrPDB 69 6e-12 3EB0-A nrPDB 68 8e-12 4PL5-B nrPDB 68 9e-12 5GNK-A nrPDB 68 1e-11 2PVN-A nrPDB 67 1e-11 5LPV-A nrPDB 67 2e-11 5LPZ-A nrPDB 67 2e-11 3CJF-A nrPDB 67 2e-11 2BUJ-A nrPDB 67 2e-11 3NIE-A nrPDB 67 2e-11 4R7H-A nrPDB 67 2e-11 5VDK-A nrPDB 67 2e-11 5M07-A nrPDB 67 2e-11 3QD2-B nrPDB 66 3e-11 1LUF-A nrPDB 66 4e-11 2I6L-A nrPDB 66 5e-11 3Q4U-A nrPDB 65 5e-11 3LZB-A nrPDB 65 5e-11 6GQK-A nrPDB 65 6e-11 4O2Z-A nrPDB 65 6e-11 6FER-A nrPDB 65 6e-11 3MY0-A nrPDB 65 6e-11 5U6C-A nrPDB 65 6e-11 4XLV-A nrPDB 65 7e-11 5HLW-A nrPDB 65 7e-11 2Y4I-B nrPDB 65 8e-11 3RP9-A nrPDB 65 8e-11 5VC6-A nrPDB 65 9e-11 6FEX-A nrPDB 65 1e-10 5X02-A nrPDB 65 1e-10 3C1X-A nrPDB 65 1e-10 6HMD-A nrPDB 65 1e-10 4XUF-A nrPDB 64 1e-10 3G0E-A nrPDB 64 2e-10 4LRM-A nrPDB 63 3e-10 6BSD-A nrPDB 63 4e-10 3MDY-A nrPDB 62 5e-10 5WNO-A nrPDB 62 7e-10 3G2F-A nrPDB 62 8e-10 4CRL-A nrPDB 62 9e-10 2PZI-A nrPDB 62 9e-10 1PY5-A nrPDB 61 1e-09 3RAW-A nrPDB 60 2e-09 4Y12-A nrPDB 60 3e-09 5UNP-A nrPDB 60 3e-09 4IAN-A nrPDB 60 3e-09 3SOC-A nrPDB 59 4e-09 3PP0-A nrPDB 59 5e-09 5AR8-A nrPDB 59 5e-09 4F9B-A nrPDB 59 6e-09 3VHK-A nrPDB 59 7e-09 5XD6-A nrPDB 58 9e-09 5X1R-A nrPDB 58 1e-08 3I81-A nrPDB 57 2e-08 2QLU-A nrPDB 57 3e-08 3LLT-A nrPDB 56 5e-08 3HNG-A nrPDB 55 8e-08 3SV0-A nrPDB 54 1e-07 4M69-B nrPDB 54 2e-07 2WO6-A nrPDB 54 2e-07 3ZBF-A nrPDB 54 2e-07 4BTF-A nrPDB 53 3e-07 4RT7-A nrPDB 52 7e-07 4TN6-A nrPDB 52 7e-07 5E8V-A nrPDB 52 7e-07 6BFN-A nrPDB 51 1e-06 4L68-A nrPDB 51 1e-06 3AOX-A nrPDB 51 2e-06 4MWI-A nrPDB 50 2e-06 4XHL-A nrPDB 50 2e-06 3REP-A nrPDB 50 2e-06 4XHH-A nrPDB 49 4e-06 5CLR-A nrPDB 49 5e-06 5X18-A nrPDB 49 8e-06 5FQD-C nrPDB 46 3e-05 2CMW-A nrPDB 45 6e-05 4L00-A nrPDB 45 8e-05 4JRN-A nrPDB 45 1e-04 3PG1-A nrPDB 45 1e-04 5UV4-A nrPDB 44 1e-04 4BTK-A nrPDB 44 2e-04 4NFN-A nrPDB 44 2e-04 5USZ-A nrPDB 44 2e-04 6EAS-A nrPDB 43 4e-04 4NT4-A nrPDB 42 5e-04 6J6I-B nrPDB 42 5e-04 2CHL-A nrPDB 41 0.001 5OAT-A nrPDB 41 0.001 4I94-A nrPDB 41 0.001 2C47-A nrPDB 41 0.001 3DZO-A nrPDB 40 0.003 4AZV-A nrPDB 40 0.004 1CSN-A nrPDB 39 0.004 4O1O-A nrPDB 39 0.005 4AZW-A nrPDB 39 0.006 4CI6-B nrPDB 38 0.012 4WUA-A nrPDB 38 0.014 2W1Z-A nrPDB 38 0.015 6G4J-A nrPDB 37 0.021 3BYV-A nrPDB 36 0.037 6EQI-C nrPDB 36 0.038 5UU1-A nrPDB 35 0.089 2RSV-A nrPDB 35 0.089 4OAU-C nrPDB 35 0.10 2LAV-A nrPDB 35 0.11 5C01-A nrPDB 34 0.14 4WOV-A nrPDB 34 0.17 2X7G-A nrPDB 33 0.28 6BHC-A nrPDB 33 0.31 5DMZ-A nrPDB 33 0.37 1QTR-A nrPDB 31 1.1 6EWX-A nrPDB 30 2.1 2R2Q-A nrPDB 30 2.5 1EIF-A nrPDB 30 2.5 5LXH-A nrPDB 30 2.8 2JII-A nrPDB 30 2.9 3BGY-A nrPDB 28 7.3 >4CFF-A nrPDB Length = 571 Score = 1151 bits (2977), Expect = 0.0, Method: Compositional matrix adjust. Identities = 552/552 (100%), Positives = 552/552 (100%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK Sbjct: 20 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 79 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF Sbjct: 80 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 139 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA Sbjct: 140 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS Sbjct: 200 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 259 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF Sbjct: 260 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 319 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 360 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP Sbjct: 320 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 379 Query: 361 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 420 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY Sbjct: 380 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 439 Query: 421 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 480 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR Sbjct: 440 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 499 Query: 481 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 540 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF Sbjct: 500 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 559 Query: 541 EMCASLITTLAR 552 EMCASLITTLAR Sbjct: 560 EMCASLITTLAR 571 >5EZV-A nrPDB Length = 560 Score = 1079 bits (2791), Expect = 0.0, Method: Compositional matrix adjust. Identities = 523/551 (94%), Positives = 531/551 (96%), Gaps = 6/551 (1%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI Sbjct: 16 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 75 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ Sbjct: 76 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 135 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA Sbjct: 136 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 195 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV Sbjct: 196 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 255 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE Sbjct: 256 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 315 Query: 302 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPP 361 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPP SF+DD + Sbjct: 316 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPD-SFLDDHHL---- 370 Query: 362 GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYR 421 +PHPER+P L+A++P+AR LD LN K K VKKAKWHLGIRSQSKPYDIMAEVYR Sbjct: 371 -TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVKKAKWHLGIRSQSKPYDIMAEVYR 429 Query: 422 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS 481 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS Sbjct: 430 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS 489 Query: 482 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFE 541 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFE Sbjct: 490 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFE 549 Query: 542 MCASLITTLAR 552 MCASLITTLAR Sbjct: 550 MCASLITTLAR 560 >4REW-A nrPDB Length = 540 Score = 848 bits (2191), Expect = 0.0, Method: Compositional matrix adjust. Identities = 409/546 (74%), Positives = 466/546 (85%), Gaps = 8/546 (1%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G VKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGKI+REIQNL Sbjct: 1 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 60 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 KLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLFQQILS VD Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248 LYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI G+FY P+YLN SV +LL HM Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 240 Query: 249 LQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVM 308 LQVDP+KRA+IKDIREHEWFKQDLP YLFPEDPSY + +IDDEA+KEVCEKFEC+E EV+ Sbjct: 241 LQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL 300 Query: 309 NSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPE 368 + LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP SF+DD + +PHPE Sbjct: 301 SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL-----TRPHPE 354 Query: 369 RMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDF 428 R+P L+A++P+AR LD LN K K V+KAKWHLGIRSQS+P DIMAEV RA+KQLD+ Sbjct: 355 RVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDY 414 Query: 429 EWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQR 488 EWKVVN Y+LRVRRKNPVT Y KMSLQLY VD+R+YLLDF+SIDD + SG++TPQR Sbjct: 415 EWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDGITAAASGTATPQR 474 Query: 489 SCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTG--STLSSVSPRLGSHTMDFFEMCASL 546 S S + + S A+ S SLT S+T S+ ++PR GSHT++FFEMCA+L Sbjct: 475 SGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANL 534 Query: 547 ITTLAR 552 I LA+ Sbjct: 535 IKILAQ 540 >4CFH-A nrPDB Length = 493 Score = 815 bits (2104), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/478 (80%), Positives = 432/478 (90%), Gaps = 6/478 (1%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 MAEKQKHDGRVKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGK Sbjct: 20 MAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 79 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I+REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLF Sbjct: 80 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 139 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA Sbjct: 140 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI G+FY P+YLN S Sbjct: 200 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 259 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 V +LL HMLQVDP+KRATIKDIREHEWFKQDLP YLFPEDPSY + +IDDEA+KEVCEKF Sbjct: 260 VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKF 319 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 360 EC+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP SF+DD + Sbjct: 320 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL--- 375 Query: 361 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 420 +PHPER+P L+A++P+AR LD LN K K V+KAKWHLGIRSQS+P DIMAEV Sbjct: 376 --TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVC 433 Query: 421 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVE 478 RA+KQLD+EWKVVN Y+LRVRRKNPVT + KMSLQLY VD+R+YLLDF+SIDDE++E Sbjct: 434 RAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEILE 491 >4RED-A nrPDB Length = 351 Score = 623 bits (1606), Expect = e-179, Method: Compositional matrix adjust. Identities = 295/352 (83%), Positives = 322/352 (91%), Gaps = 1/352 (0%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 M H G VKIGHY+LGDTLGVGTFGKVK+G+H+LTGH VAVKILNRQKIRSLDVVGK Sbjct: 1 MGHHHHHHGSVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGK 60 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I+REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLF Sbjct: 61 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 120 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA Sbjct: 121 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI G+FY P+YLN S Sbjct: 181 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 240 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 V +LL HMLQVDP+KRA+IKDIREHEWFKQDLP YLFPEDPSY +IDDEA+KEVCEKF Sbjct: 241 VISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKF 300 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFM 352 EC+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP SF+ Sbjct: 301 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFL 351 >2YZA-A nrPDB Length = 276 Score = 573 bits (1476), Expect = e-164, Method: Compositional matrix adjust. Identities = 273/274 (99%), Positives = 273/274 (99%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI Sbjct: 3 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 62 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS Sbjct: 63 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 122 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR SCGSPNYAAPEVI Sbjct: 123 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVI 182 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL Sbjct: 183 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 242 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 279 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE Sbjct: 243 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 276 >3H4J-B nrPDB Length = 336 Score = 359 bits (922), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 172/336 (51%), Positives = 240/336 (71%), Gaps = 8/336 (2%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 MA ++H IG Y++ +TLG G+FGKVK+ H T KVA+K ++RQ ++ D+ + Sbjct: 1 MAISKRH-----IGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMR 55 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 ++REI LKL RHPHIIKLY VI+TPTD MV+EY +GGELFDYI + R+ E E RR F Sbjct: 56 VEREISYLKLLRHPHIIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFF 114 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQI+ A++YCHRH +VHRDLKPEN+LLD ++N KIADFGLSN+M+DG FL+TSCGSPNYA Sbjct: 115 QQIICAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYA 174 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVI+G+LYAGPEVD+WSCG++LY +L G LPFDDE +P LFKK+ V+ +P++L+ Sbjct: 175 APEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPG 234 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 +L+ M+ DP++R TI++IR WF +LP YL P + + D V ++ E Sbjct: 235 AQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPME-EVQGSYADSRIVSKLGEAM 293 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQ 336 +E ++ +L S D +++ AY+L+ +N+ I + Sbjct: 294 GFSEDYIVEALRS-DENNEVKEAYNLLHENQVIQEK 328 >3MN3-A nrPDB Length = 271 Score = 359 bits (922), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 165/268 (61%), Positives = 208/268 (77%), Gaps = 1/268 (0%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 IG+Y + TLG G+FGKVK+ H TG KVA+KI+N++ + D+ G+I+REI L+L R Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 62 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HPHIIKLY VI + + MV+EY +G ELFDYI + ++ E EARR FQQI+SAV+YCHR Sbjct: 63 HPHIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 H +VHRDLKPEN+LLD H+N KIADFGLSN+M+DG FL+TSCGSPNYAAPEVISG+LYAG Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 PEVD+WSCGVILY +LC LPFDDE +P LFK I GV+ +P++L+ A L+ ML V+ Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVN 241 Query: 253 PLKRATIKDIREHEWFKQDLPSYLFPED 280 PL R +I +I + +WFK DLP YL P D Sbjct: 242 PLNRISIHEIMQDDWFKVDLPEYLLPPD 269 >4CZT-A nrPDB Length = 464 Score = 280 bits (716), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 129/291 (44%), Positives = 197/291 (67%), Gaps = 8/291 (2%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 H GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKREI Sbjct: 4 HSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 63 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 +KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+++A Sbjct: 64 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 123 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS----NMMSDGEFLRTSCGSPNYAAP 182 VDYCH V HRDLKPEN+LLDA+ K++DFGLS + DG L T+CG+PNY AP Sbjct: 124 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG-LLHTTCGTPNYVAP 182 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 242 EVI+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S Sbjct: 183 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 242 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 293 L+ +L +P R T ++ E+EWFK+ Y P+ + D ++ D +A+ Sbjct: 243 KLIKRILDPNPATRITFAEVIENEWFKK---GYKAPKFENADVSLDDVDAI 290 >4YNZ-A nrPDB Length = 342 Score = 273 bits (697), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 128/256 (50%), Positives = 182/256 (71%), Gaps = 1/256 (0%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 +G Y L TLG G G VK+G H +T KVA+KI+NR+K+ S V+ K++REI LKL Sbjct: 9 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 67 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HPH++KL+ V ++V+E+VSGGELFDY+ K GR+ EAR+ F+QI+SA+D+CH Sbjct: 68 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 127 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 H + HRDLKPEN+LLD N +IADFG++++ L TSCGSP+YA PEVI G Y G Sbjct: 128 HSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 + D+WSCGVIL+ALL G LPFDD+++ L +K++ GVF++P ++ +LL M++VD Sbjct: 188 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 247 Query: 253 PLKRATIKDIREHEWF 268 +R T++ I++H W+ Sbjct: 248 AARRLTLEHIQKHIWY 263 >5KZ7-A nrPDB Length = 346 Score = 270 bits (689), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 145/331 (43%), Positives = 206/331 (62%), Gaps = 18/331 (5%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 A++Q H IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ S + K+ Sbjct: 26 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS-SSLQKL 79 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE++ +K+ HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+ Sbjct: 80 FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 139 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QI+SAV YCH+ +VHRDLK EN+LLDA MN KIADFG SN + G L T CGSP YAA Sbjct: 140 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 199 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE+ G+ Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ Sbjct: 200 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 259 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296 LL L ++P KR T++ I + W +L Y+ P P Y D E+ Sbjct: 260 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPL-PDY-----KDPRRTEL 313 Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327 T E+ +SL G +++ Y L+ Sbjct: 314 MVSMGYTREEIQDSL-VGQRYNEVMATYLLL 343 >2QNJ-A nrPDB Length = 328 Score = 270 bits (689), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 131/282 (46%), Positives = 188/282 (66%), Gaps = 6/282 (2%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 IG+Y L T+G G F KVK+ H LTG +VA+KI+++ ++ + K+ RE++ +K+ Sbjct: 11 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL-QKLFREVRIMKILN 69 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+I+KL++VI T +++MEY SGGE+FDY+ HGR++E EAR F+QI+SAV YCH+ Sbjct: 70 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 129 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 +VHRDLK EN+LLDA MN KIADFG SN + G L T CGSP YAAPE+ G+ Y G Sbjct: 130 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 189 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 PEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ LL L ++ Sbjct: 190 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 249 Query: 253 PLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVID 289 P+KR T++ I + W + +L ++ PE D ID Sbjct: 250 PIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID 291 >6C9D-A nrPDB Length = 459 Score = 263 bits (673), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 157/426 (36%), Positives = 239/426 (56%), Gaps = 53/426 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ + K+ RE++ +K+ Sbjct: 20 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL-QKLFREVRIMKILN 78 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+QI+SAV YCH+ Sbjct: 79 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 138 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 +VHRDLK EN+LLD MN KIADFG SN + G L CGSP YAAPE+ G+ Y G Sbjct: 139 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDG 198 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 PEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ LL +L ++ Sbjct: 199 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 258 Query: 253 PLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEV 307 P+KR +++ I + W +++L Y P+ D ID + Sbjct: 259 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRID-----------------I 301 Query: 308 MNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHP 367 M ++ G +D++ N ++NQ + +A+ +I G KP Sbjct: 302 MVTM--GFARDEI---------NDALINQKYDEVMAT-------------YILLGRKPPE 337 Query: 368 ERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAM--KQ 425 ++ PK R + + +KP+SL + W + S P D+M E+ + + Sbjct: 338 FEGGESLSGEPKERDKEEGKD-SKPRSL---RFTWSMKTTSSMDPNDMMREIRKVLDANN 393 Query: 426 LDFEWK 431 D+E K Sbjct: 394 CDYEQK 399 >2HAK-A nrPDB Length = 328 Score = 262 bits (669), Expect = 4e-70, Method: Compositional matrix adjust. Identities = 131/282 (46%), Positives = 188/282 (66%), Gaps = 6/282 (2%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ + K+ RE++ +K+ Sbjct: 14 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL-QKLFREVRIMKILN 72 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+QI+SAV YCH+ Sbjct: 73 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 132 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 +VHRDLK EN+LLD MN KIADFG SN + G L T CGSP YAAPE+ G+ Y G Sbjct: 133 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 192 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 PEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ LL +L ++ Sbjct: 193 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 252 Query: 253 PLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVID 289 P+KR +++ I + W +++L Y P+ D ID Sbjct: 253 PIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRID 294 >5ES1-A nrPDB Length = 328 Score = 261 bits (668), Expect = 4e-70, Method: Compositional matrix adjust. Identities = 140/330 (42%), Positives = 202/330 (61%), Gaps = 18/330 (5%) Query: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62 E+Q H +G+Y L T+G G F KVK+ H LTG +VA+KI+++ ++ + K+ Sbjct: 9 EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP-SSLQKLF 62 Query: 63 REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122 RE++ +K HP+I+KL++VI T ++VMEY S GE+FDY+ HGR++E EAR F+Q Sbjct: 63 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQ 122 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 I+SAV YCH+ +VHRDLK EN+LLDA N KIADFG SN + G L T CGSP YAAP Sbjct: 123 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAP 182 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 242 E+ G+ Y GPEVDIWS GVILY L+ G+LPFD ++ L +++ G + +P Y++ Sbjct: 183 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCE 242 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEVC 297 ++L L ++P KR T++ I + +W ++L Y PE+ D I EV Sbjct: 243 SILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRI------EVM 296 Query: 298 EKFECTESEVMNSLYSGDPQDQLAVAYHLI 327 T E+ SL S +++ Y L+ Sbjct: 297 VGMGYTREEIKESLTS-QKYNEVTATYLLL 325 >4D28-A nrPDB Length = 446 Score = 256 bits (654), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 144/399 (36%), Positives = 223/399 (55%), Gaps = 31/399 (7%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 RHP+I++LY+V+++ + ++V+E+V+GGELFD I GR++E E+R+ FQQ++ AV +CH Sbjct: 67 RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 190 V HRDLKPEN+LLD + N K++DFGLS + +G E L +CG+PNY APEV+SG+ Y Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRILD 246 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTE-SEVMN 309 +P R I+ I++ WF+++ E+ + N+ D AV F+ E S V Sbjct: 247 PNPKTRIQIQGIKKDPWFRKNYVPIRAREEE--EVNLDDIRAV------FDGIEGSYVAE 298 Query: 310 SLYSGDPQDQLAVAYHLI-----------IDNRRIMNQASEFYLASSPPSGSFMDDSAMH 358 ++ D + A+ +I D R+ + +++ PS + A+ Sbjct: 299 NVERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVA 358 Query: 359 IPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAV 397 G K H + L+ L++ K LAV Sbjct: 359 NSMGFKSHTRNF----------KTRLEGLSSIKAGQLAV 387 >4CQG-A nrPDB Length = 331 Score = 244 bits (623), Expect = 7e-65, Method: Compositional matrix adjust. Identities = 123/261 (47%), Positives = 166/261 (63%), Gaps = 4/261 (1%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + +Y L +T+G G F KVK+ H LTG VA+KI+++ + S + ++K EI LK R Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLR 65 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H HI +LY V+ T FMV+EY GGELFDYI R+ E E R +F+QILSAV Y H Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLY 190 HRDLKPEN+L D + K+ DFGL + L+ CGS YAAPE+I G+ Y Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 G E D+WS G++LY L+CG LPFDD++V L+KKI G + +P++L+ S LL MLQ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQ 245 Query: 251 VDPLKRATIKDIREHEWFKQD 271 VDP KR +++++ H W QD Sbjct: 246 VDPKKRISMRNLLNHPWVMQD 266 >4D2V-A nrPDB Length = 356 Score = 241 bits (614), Expect = 9e-64, Method: Compositional matrix adjust. Identities = 129/288 (44%), Positives = 177/288 (61%), Gaps = 9/288 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + +Y L +T+G G F KVK+ H LTG VA+KI+++ + S + +IK EI+ LK R Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLR 85 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H HI +LY V+ T FMV+EY GGELFDYI R+ E E R +F+QI+SAV Y H Sbjct: 86 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLY 190 HRDLKPEN+L D + K+ DFGL + L+ CG+ YAAPE+I G+ Y Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSY 205 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 G E D+WS G++LY L+CG LPFDD+ L KI G + +P++L+ S LL MLQ Sbjct: 206 LGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQ 265 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFP-EDPSYDANV-IDDEAVKEV 296 VDP KR ++K++ H W QD Y +P E S + + +DD+ V E+ Sbjct: 266 VDPKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTEL 310 >5YKS-A nrPDB Length = 377 Score = 224 bits (572), Expect = 6e-59, Method: Compositional matrix adjust. Identities = 114/273 (41%), Positives = 171/273 (62%), Gaps = 4/273 (1%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 K+ +DG++ G Y L TLG G F VK+ H TG KVAVK++++ K+ +L G + + Sbjct: 26 KRGYDGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 83 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQ 122 E++ +KL +HP+I++LY+VI T T ++++E GG++FDYI KH + E A++ F Q Sbjct: 84 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 143 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLL-DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 I+ A+ YCH+ VVHRDLKPENV+ + K+ DFG SN G+ L TSCGS Y+A Sbjct: 144 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 203 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE++ G Y P VDIWS GVIL+ L+CG PF + + I + +P ++++ Sbjct: 204 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 263 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 L+ MLQ DP +RA++++I H W + PS Sbjct: 264 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPS 296 >5WAX-A nrPDB Length = 310 Score = 204 bits (519), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 118/280 (42%), Positives = 156/280 (55%), Gaps = 18/280 (6%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIKREI 65 HDG Y L +G G FG ++ ++ G VAVK + R +KI ++REI Sbjct: 8 HDG----DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDE-----NVQREI 58 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 N + RHP+II+ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S Sbjct: 59 INHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLIS 118 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 V YCH V HRDLK EN LLD KI DFG S +++ G+P Y APE Sbjct: 119 GVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE 178 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNR 239 V+ + Y G D+WSCGV LY +L G PF+D P F+K I G + IP+Y++ Sbjct: 179 VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHI 238 Query: 240 S--VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF 277 S L+ + +P R TI +IR H WF ++LP+ L Sbjct: 239 SPECQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLM 278 >3UDB-A nrPDB Length = 317 Score = 202 bits (514), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 115/274 (41%), Positives = 154/274 (56%), Gaps = 14/274 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIKREIQNLKLFRHP 74 Y L +G G FG ++ + VAVK + R +KI +KREI N + RHP Sbjct: 21 YELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDE-----NVKREIINHRSLRHP 75 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V Y H Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQ 135 Query: 135 VVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 V HRDLK EN LLD KIADFG S +++ G+P Y APEV+ + Y G Sbjct: 136 VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDG 195 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRSVAT--LLM 246 D+WSCGV LY +L G PF+D P F+K I + IP+Y++ S L+ Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 280 + DP KR +I +IR HEWF ++LP+ L ++ Sbjct: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMNDN 289 >3ZUT-A nrPDB Length = 362 Score = 200 bits (508), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 114/274 (41%), Positives = 154/274 (56%), Gaps = 14/274 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIKREIQNLKLFRHP 74 Y L +G G FG ++ + + VAVK + R +KI +KREI N + RHP Sbjct: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDE-----NVKREIINHRSLRHP 75 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V YCH Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQ 135 Query: 135 VVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 V HRDLK EN LLD KI FG S +++ G+P Y APEV+ + Y G Sbjct: 136 VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRSVAT--LLM 246 D+WSCGV LY +L G PF+D P F+K I + IP+Y++ S L+ Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLIS 255 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 280 + DP KR +I +IR HEWF ++LP+ L ++ Sbjct: 256 RIFVADPAKRISIPEIRNHEWFLKNLPADLMNDN 289 >3UC3-A nrPDB Length = 361 Score = 191 bits (485), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 106/266 (39%), Positives = 147/266 (55%), Gaps = 12/266 (4%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G FG ++ +LT VAVK + R + ++REI N + RHP+I++ + Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIER----GAAIDENVQREIINHRSLRHPNIVRFKE 83 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 VI TPT ++MEY SGGEL++ IC GR E EAR FQQ+LS V YCH + HRDLK Sbjct: 84 VILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLK 143 Query: 142 PENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 EN LLD KI DFG S +++ G+P Y APEV+ + Y G D+WS Sbjct: 144 LENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWS 203 Query: 200 CGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEYLNRS--VATLLMHMLQVDP 253 CGV LY +L G PF+D P ++K I + IP+ + S L+ + DP Sbjct: 204 CGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRIFVADP 263 Query: 254 LKRATIKDIREHEWFKQDLPSYLFPE 279 R +I +I+ H WF ++LP+ L E Sbjct: 264 ATRISIPEIKTHSWFLKNLPADLMNE 289 >3F3Z-A nrPDB Length = 277 Score = 188 bits (477), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 106/267 (39%), Positives = 153/267 (57%), Gaps = 12/267 (4%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y L +T+G G++G+VKI + T + A K + + + +D + K+EI+ +K HP Sbjct: 10 YYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD---RFKQEIEIMKSLDHP 66 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +II+LY+ TD ++VME +GGELF+ + E +A R+ + +LSAV YCH+ Sbjct: 67 NIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLN 126 Query: 135 VVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 V HRDLKPEN L K+ DFGL+ G+ +RT G+P Y +P+V+ G LY Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG-LY- 184 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE--YLNRS--VATLLMH 247 GPE D WS GV++Y LLCG PF + KIR G F PE +LN S +L+ Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 248 MLQVDPLKRATIKDIREHEWFKQDLPS 274 +L P +R T EHEWF++ L S Sbjct: 245 LLTKSPKQRITSLQALEHEWFEKQLSS 271 >2JC6-A nrPDB Length = 334 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 100/263 (38%), Positives = 149/263 (56%), Gaps = 10/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + +TLG G F +V + E + TG AVK + ++ ++ + I+ EI L+ +H + Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SSIENEIAVLRKIKHEN 81 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L + +P ++VM+ VSGGELFD I + G E +A L +Q+L AV Y HR + Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 136 VHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 VHRDLKPEN+L D I+DFGLS M G+ + T+CG+P Y APEV++ + Y+ Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 201 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLMHM 248 VD WS GVI Y LLCG PF DE+ LF++I + P + ++ S + ++ Sbjct: 202 A-VDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNL 260 Query: 249 LQVDPLKRATIKDIREHEWFKQD 271 ++ DP KR T + H W D Sbjct: 261 MEKDPNKRYTCEQAARHPWIAGD 283 >2Y8Q-A nrPDB Length = 173 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 91/148 (61%), Positives = 112/148 (75%), Gaps = 2/148 (1%) Query: 402 WHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVD 461 WHLGIRSQS+P DIMAEV RA+KQLD+EWKVVN Y+LRVRRKNPVT + KMSLQLY VD Sbjct: 19 WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVD 78 Query: 462 NRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLT 521 +R+YLLDF+SIDDE+ E +SG++TPQRS S + + S A+ SLT S+T Sbjct: 79 SRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVT 138 Query: 522 G--STLSSVSPRLGSHTMDFFEMCASLI 547 S+ V+PR GSHT++FFEMCA+LI Sbjct: 139 SLDSSPVDVAPRPGSHTIEFFEMCANLI 166 >5JN2-A nrPDB Length = 525 Score = 182 bits (463), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 103/316 (32%), Positives = 173/316 (54%), Gaps = 9/316 (2%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V + + ++TG + AVK++++++++ + RE+Q LK HP+I+KLY+ Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 134 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 F++V E +GGELFD I R E++A R+ +Q+LS + Y H++ +VHRDLK Sbjct: 135 FFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLK 194 Query: 142 PENVLLDAH---MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL++ N +I DFGLS + ++ G+ Y APEV+ G + D+W Sbjct: 195 PENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTY--DEKCDVW 252 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEY--LNRSVATLLMHMLQVDPL 254 S GVILY LL G PF+ + + KK+ G F +P++ ++ S L+ ML P Sbjct: 253 STGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPS 312 Query: 255 KRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSG 314 R + +D +HEW + + + PS D +++ + + + + + L S Sbjct: 313 MRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQ 372 Query: 315 DPQDQLAVAYHLIIDN 330 D +L +H + N Sbjct: 373 DETKELTAIFHKMDKN 388 >4FG9-A nrPDB Length = 320 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 102/263 (38%), Positives = 147/263 (55%), Gaps = 10/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y D LG G F +V + E + T VA+K + ++ + + G ++ EI L +HP+ Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIKHPN 77 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L + + +++M+ VSGGELFD I + G E +A RL Q+L AV Y H + Sbjct: 78 IVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGI 137 Query: 136 VHRDLKPENVL---LDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 VHRDLKPEN+L LD I+DFGLS M G L T+CG+P Y APEV++ + Y+ Sbjct: 138 VHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSK 197 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLMHM 248 VD WS GVI Y LLCG PF DE+ LF++I + P + ++ S + H+ Sbjct: 198 A-VDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHL 256 Query: 249 LQVDPLKRATIKDIREHEWFKQD 271 ++ DP KR T + +H W D Sbjct: 257 MEKDPEKRFTCEQALQHPWIAGD 279 >3MA6-A nrPDB Length = 298 Score = 177 bits (450), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 94/256 (36%), Positives = 151/256 (58%), Gaps = 9/256 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G+FG+V + + ++TG + AVK++++++++ + RE+Q LK HP+I+KLY Sbjct: 39 VLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLY 98 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + F++V E +GGELFD I R E++A R+ +Q+LS + Y H++ +VHRDL Sbjct: 99 EFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDL 158 Query: 141 KPENVLLDAH---MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 KPEN+LL++ N +I DFGLS + ++ G+ Y APEV+ G + D+ Sbjct: 159 KPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTY--DEKCDV 216 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEY--LNRSVATLLMHMLQVDP 253 WS GVILY LL G PF+ + + KK+ G F +P++ ++ S L+ ML P Sbjct: 217 WSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVP 276 Query: 254 LKRATIKDIREHEWFK 269 R + +D +HEW + Sbjct: 277 SMRISARDALDHEWIQ 292 >2JAM-A nrPDB Length = 304 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 103/260 (39%), Positives = 151/260 (58%), Gaps = 14/260 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ-KIRSLDVVGKIKREIQNLKLFRHP 74 ++ + LG G F +V + + +LTG A+K + + R ++ EI LK +H Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD----SSLENEIAVLKKIKHE 66 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I+ L + + T +++VM+ VSGGELFD I + G E +A + QQ+LSAV Y H + Sbjct: 67 NIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 126 Query: 135 VVHRDLKPENVL-LDAHMNAK--IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +VHRDLKPEN+L L N+K I DFGLS M +G + T+CG+P Y APEV++ + Y+ Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPEVLAQKPYS 185 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--FYIPEY--LNRSVATLLMH 247 VD WS GVI Y LLCG PF +E LF+KI+ G F P + ++ S + H Sbjct: 186 KA-VDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICH 244 Query: 248 MLQVDPLKRATIKDIREHEW 267 +L+ DP +R T + H W Sbjct: 245 LLEKDPNERYTCEKALSHPW 264 >4RGJ-A nrPDB Length = 520 Score = 175 bits (443), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 94/256 (36%), Positives = 147/256 (57%), Gaps = 10/256 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V + + TGH+ A+K+++++ ++ + RE++ LK+ H +I+KLY+ Sbjct: 68 LGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYE 127 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 +++V + +GGELFD I R E++A R+ +QILS + Y H++ VVHRDLK Sbjct: 128 FFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLK 187 Query: 142 PENVLLDAH----MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 PEN+LL+ M KI DFGLS + ++ G+ Y AP+V+ G + DI Sbjct: 188 PENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTY--DEKCDI 245 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEY--LNRSVATLLMHMLQVDP 253 WSCGVILY LL G PF+ + + KK+ G F +P++ ++ L+ ML Sbjct: 246 WSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTS 305 Query: 254 LKRATIKDIREHEWFK 269 R + +D EHEW K Sbjct: 306 AVRISARDALEHEWIK 321 >3NCG-A nrPDB Length = 486 Score = 174 bits (442), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 98/269 (36%), Positives = 151/269 (56%), Gaps = 19/269 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V + ++T + AVK++N+ ++ D I RE++ LK HP+I+KL++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDT-STILREVELLKKLDHPNIMKLFE 88 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 ++ + F++V E +GGELFD I K R E +A R+ +Q+ S + Y H+H +VHRDLK Sbjct: 89 ILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLK 148 Query: 142 PENVLLDAH---MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL++ + KI DFGLS ++ G+ Y APEV+ G + D+W Sbjct: 149 PENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTY--DEKCDVW 206 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEY--LNRSVATLLMHMLQVDPL 254 S GVILY LL GT PF ++ + K++ G F +P++ ++ L+ ML P Sbjct: 207 SAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPS 266 Query: 255 KRATIKDIREHEWFKQ---------DLPS 274 R T EH W ++ DLPS Sbjct: 267 LRITATQCLEHPWIQKYSSETPTISDLPS 295 >4MVF-A nrPDB Length = 506 Score = 174 bits (440), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 96/271 (35%), Positives = 148/271 (54%), Gaps = 13/271 (4%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 H G+++ Y++ + LG GT+G V G ++T A+K + ++++ + + +EI+ Sbjct: 51 HSGKLE-DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKN---INRFFQEIE 106 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 +K HP+I+KLY+ +++ME SG ELFD I ++G E A + +QI SA Sbjct: 107 IMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 + Y H +VHRDLKPEN L + KI DFGLS + GEF T G+P Y AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY----LNR 239 V+ G+ + DIWS GVI+Y LLCG PF + + KK++ G F E ++ Sbjct: 227 VLDGKY--DKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISS 284 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 L+ +L +P +R TI++ H W Q Sbjct: 285 DAKNLITKLLTYNPNERCTIEEALNHPWITQ 315 >5IG1-A nrPDB Length = 344 Score = 173 bits (439), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 100/261 (38%), Positives = 147/261 (56%), Gaps = 10/261 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G F V ++ TG AVK++ + +RS ++ KIKREI +H HI+ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEI-NKIKREIGICSSLQHEHIVSMR 82 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + + F++V EYVSGGELFD I E +A QILSA+ +CH ++HRDL Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 141 KPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 KPEN+LL D + KI DFGL+ +M G G+P Y +PEVI R+ VD+ Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIR-RVPYDTAVDV 201 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT----LLMHMLQVDP 253 W+CGVILY LL G PF +E L+ +I+ + P SV T L+ ML+ +P Sbjct: 202 WACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPNP 261 Query: 254 LKRATIKDIREHEWF-KQDLP 273 +R T++++ +H W ++D+P Sbjct: 262 KRRPTVQELLQHPWIARRDVP 282 >3DFA-A nrPDB Length = 286 Score = 172 bits (436), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 94/256 (36%), Positives = 147/256 (57%), Gaps = 10/256 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V + ++T + AVK++N+ ++ D I RE++ LK HP+I+KL++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDT-STILREVELLKKLDHPNIMKLFE 88 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 ++ + F++V E +GGELFD I K R E +A R+ +Q+ S + Y H+H +VHRDLK Sbjct: 89 ILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLK 148 Query: 142 PENVLLDAH---MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL++ + KI DFGLS ++ G+ Y APEV+ G + D+W Sbjct: 149 PENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTY--DEKCDVW 206 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEY--LNRSVATLLMHMLQVDPL 254 S GVILY LL GT PF ++ + K++ G F +P++ ++ L+ ML P Sbjct: 207 SAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKMLTFHPS 266 Query: 255 KRATIKDIREHEWFKQ 270 R T EH W ++ Sbjct: 267 LRITATQCLEHPWIQK 282 >2BDW-A nrPDB Length = 362 Score = 171 bits (432), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 96/261 (36%), Positives = 148/261 (56%), Gaps = 9/261 (3%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y + + LG G F V+ H+ TG + A KI+N +K+ + D K++RE + + +HP Sbjct: 30 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDF-QKLEREARICRKLQHP 88 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I++L+ I + ++V + V+GGELF+ I E +A QQIL ++ YCH + Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNG 148 Query: 135 VVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +VHR+LKPEN+LL + K+ADFGL+ ++D E G+P Y +PEV+ Y+ Sbjct: 149 IVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYS 208 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VDIW+CGVILY LL G PF DE L+ +I+ G + P + + +L+ Sbjct: 209 KP-VDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDS 267 Query: 248 MLQVDPLKRATIKDIREHEWF 268 ML V+P KR T + W Sbjct: 268 MLTVNPKKRITADQALKVPWI 288 >5XZW-A nrPDB Length = 471 Score = 171 bits (432), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 20/270 (7%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 ++ + +G G F VK + TG AVKI++++K+ + + + RE++ L+ HP I Sbjct: 199 IIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKV--IGNMDGVTRELEVLQKLNHPRI 256 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 ++L ++MVME+VSGG+L D++ HG V E R + +QIL+A+ Y H + Sbjct: 257 VRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 137 HRDLKPENVLL--DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR-LYAGP 193 HRDLKP+N+L+ D + KI DFGL+ + +G F++T CG+ Y APEVI G+ P Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 194 E-----------VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY---IPEY-LN 238 + VD+WS G ++Y +L G LPF L+K+I G ++ + ++ ++ Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 436 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + +LQVDP R+T H W Sbjct: 437 EEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >3BHH-A nrPDB Length = 295 Score = 170 bits (431), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 100/263 (38%), Positives = 147/263 (55%), Gaps = 10/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + +G G F V+ TGH+ A KI+N +K+ + D K++RE + +L +H + Sbjct: 6 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDH-QKLEREARICRLLKHSN 64 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS ++V + V+GGELF+ I E +A QQIL AV +CH+ V Sbjct: 65 IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 124 Query: 136 VHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + K+ADFGL+ + D + G+P Y +PEV+ Y Sbjct: 125 VHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYG 184 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VDIW+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 185 KP-VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 243 Query: 248 MLQVDPLKRATIKDIREHEWFKQ 270 ML ++P KR T + +H W Q Sbjct: 244 MLTINPAKRITAHEALKHPWVCQ 266 >3KK8-A nrPDB Length = 284 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 96/261 (36%), Positives = 148/261 (56%), Gaps = 9/261 (3%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y + + LG G F V+ H+ TG + A KI+N +K+ + D K++RE + + +HP Sbjct: 7 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDF-QKLEREARICRKLQHP 65 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I++L+ I + ++V + V+GGELF+ I E +A QQIL ++ YCH + Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNG 125 Query: 135 VVHRDLKPENVLLDAHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +VHR+LKPEN+LL + K+ADFGL+ ++D E G+P Y +PEV+ Y+ Sbjct: 126 IVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYS 185 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VDIW+CGVILY LL G PF DE L+ +I+ G + P + + +L+ Sbjct: 186 KP-VDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDS 244 Query: 248 MLQVDPLKRATIKDIREHEWF 268 ML V+P KR T + W Sbjct: 245 MLTVNPKKRITADQALKVPWI 265 >2Y7J-A nrPDB Length = 365 Score = 169 bits (429), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 100/266 (37%), Positives = 149/266 (56%), Gaps = 15/266 (5%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILN----RQKIRSLDVVGK-IKREIQNLK-LFRH 73 D +G G V+ H+ TGH+ AVKI+ R L+ V + +RE L+ + H Sbjct: 100 DVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGH 159 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 PHII L + + F+V + + GELFDY+ + + E E R + + +L AV + H + Sbjct: 160 PHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHAN 219 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-- 191 +VHRDLKPEN+LLD +M +++DFG S + GE LR CG+P Y APE++ + Sbjct: 220 NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETH 279 Query: 192 ---GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEYLNRS--VATL 244 G EVD+W+CGVIL+ LL G+ PF + + I G F PE+ +RS V L Sbjct: 280 PGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDL 339 Query: 245 LMHMLQVDPLKRATIKDIREHEWFKQ 270 + +LQVDP R T + +H +F++ Sbjct: 340 ISRLLQVDPEARLTAEQALQHPFFER 365 >5FG8-A nrPDB Length = 285 Score = 169 bits (429), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 99/264 (37%), Positives = 147/264 (55%), Gaps = 10/264 (3%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y + + LG G F VK + TG + A KI+N +K+ + D K++RE + + HP Sbjct: 15 NYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDF-QKLEREARICRKLHHP 73 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I++L+ I ++V + V+GGELF+ I E +A QQIL +V++CH++ Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 133 Query: 135 VVHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 VVHRDLKPEN+LL + K+ADFGL+ + D + G+P Y +PEV+ Y Sbjct: 134 VVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPY 193 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLM 246 G VDIW+CGVILY LL G PF DE L+ +I+ G + P + + L+ Sbjct: 194 -GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLIN 252 Query: 247 HMLQVDPLKRATIKDIREHEWFKQ 270 ML V+P KR T + +H W Q Sbjct: 253 QMLTVNPNKRITAAEALKHPWICQ 276 >2YCR-A nrPDB Length = 323 Score = 169 bits (428), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 100/272 (36%), Positives = 148/272 (54%), Gaps = 16/272 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI-----RSLDVVGKIKREIQNLK 69 Y++ TLG G G+VK+ + T KVA+KI++++K R D ++ EI+ LK Sbjct: 11 EYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILK 70 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 HP IIK+ D+++V+E + GGELFD + + R++E + F Q+L AV Y Sbjct: 71 KLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 129 Query: 130 CHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + ++HRDLKPENVLL + KI DFG S ++ + +RT CG+P Y APEV+ Sbjct: 130 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLV 189 Query: 187 GRLYAG--PEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGGVF-YIPEY---LNR 239 AG VD WS GVIL+ L G PF + K +I G + +IPE ++ Sbjct: 190 SVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSE 249 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 L+ +L VDP R T ++ H W + + Sbjct: 250 KALDLVKKLLVVDPKARFTTEEALRHPWLQDE 281 >4PDS-A nrPDB Length = 347 Score = 169 bits (427), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 91/271 (33%), Positives = 149/271 (54%), Gaps = 20/271 (7%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 ++ + +G G F VK + TG +VKI++++K+ + + + RE++ L+ HP I Sbjct: 34 IIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKV--IGNMDGVTRELEVLQKLNHPRI 91 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 ++L ++MVME+VSGG+L D++ HG V E R + +QIL+A+ Y H + Sbjct: 92 VRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 137 HRDLKPENVLL--DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR-LYAGP 193 HRDLKP+N+L+ D + KI FGL+ + +G F++T CG+ Y APEVI G+ P Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 194 E-----------VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY---IPEY-LN 238 + VD+WS G ++Y +L G LPF L+K+I G ++ + ++ ++ Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 271 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + +LQVDP R+T H W K Sbjct: 272 EEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >3HZT-A nrPDB Length = 467 Score = 168 bits (426), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 93/254 (36%), Positives = 141/254 (55%), Gaps = 9/254 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V + + +LTG + A+KI+ + + + G + E+ LK HP+I+KLY+ Sbjct: 12 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYE 71 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 ++++VME GGELFD I + E++A + +Q+LS Y H+H +VHRDLK Sbjct: 72 FFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLK 131 Query: 142 PENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL++ KI DFGLS G ++ G+ Y APEV+ R + D+W Sbjct: 132 PENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RKKYDEKCDVW 189 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEYLNRS--VATLLMHMLQVDPL 254 SCGVILY LLCG PF + + K++ G F P++ S L+ ML +P Sbjct: 190 SCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEPS 249 Query: 255 KRATIKDIREHEWF 268 KR + ++ H W Sbjct: 250 KRISAEEALNHPWI 263 >3DXN-A nrPDB Length = 287 Score = 168 bits (426), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 93/253 (36%), Positives = 141/253 (55%), Gaps = 9/253 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V + + +LTG + A+KI+ + + + G + E+ LK HP+I+KLY+ Sbjct: 29 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYE 88 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 ++++VME GGELFD I + E++A + +Q+LS Y H+H +VHRDLK Sbjct: 89 FFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLK 148 Query: 142 PENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL++ KI DFGLS G ++ G+ Y APEV+ R + D+W Sbjct: 149 PENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RKKYDEKCDVW 206 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEYLNRS--VATLLMHMLQVDPL 254 SCGVILY LLCG PF + + K++ G F P++ S L+ ML +P Sbjct: 207 SCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEPS 266 Query: 255 KRATIKDIREHEW 267 KR + ++ H W Sbjct: 267 KRISAEEALNHPW 279 >2VN9-A nrPDB Length = 301 Score = 168 bits (425), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 98/263 (37%), Positives = 148/263 (56%), Gaps = 10/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ TG + A KI+N +K+ + D K++RE + +L +HP+ Sbjct: 6 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 64 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS ++V + V+GGELF+ I E +A QQIL +V++CH + + Sbjct: 65 IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGI 124 Query: 136 VHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + K+ADFGL+ + D + G+P Y +PEV+ Y Sbjct: 125 VHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYG 184 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 185 KP-VDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 243 Query: 248 MLQVDPLKRATIKDIREHEWFKQ 270 ML ++P KR T + +H W Q Sbjct: 244 MLTINPAKRITASEALKHPWICQ 266 >4YZB-A nrPDB Length = 491 Score = 167 bits (424), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 95/275 (34%), Positives = 158/275 (57%), Gaps = 9/275 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V + + ++TG + AVK++++++++ + +E++ LK HP+I+KLY+ Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 F++V E +GGELFD I R E++A R+ +Q+LS + Y H++ +VHRDLK Sbjct: 98 FFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLK 157 Query: 142 PENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL+ N +I DFGLS + ++ G+ Y APEV+ G + D+W Sbjct: 158 PENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGTY--DEKCDVW 215 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEY--LNRSVATLLMHMLQVDPL 254 S GVILY LL G PF+ + + KK+ G F +P++ ++ L+ ML P Sbjct: 216 STGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPT 275 Query: 255 KRATIKDIREHEWFKQDLPSYLFPEDPSYDANVID 289 R + +D EHEW K + + PS ++ +++ Sbjct: 276 MRISARDALEHEWLKTTDAATDSIDVPSLESTILN 310 >5U6Y-A nrPDB Length = 461 Score = 167 bits (423), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 147/261 (56%), Gaps = 10/261 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ L G + A KI+N +K+ + D K++RE + +L +HP+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 60 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS +++ + V+GGELF+ I E +A QQIL AV +CH+ V Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 136 VHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + + K+ADFGL+ + + + G+P Y +PEV+ Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 180 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 181 KP-VDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 248 MLQVDPLKRATIKDIREHEWF 268 ML ++P KR T + +H W Sbjct: 240 MLTINPSKRITAAEALKHPWI 260 >3I6U-A nrPDB Length = 419 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 99/272 (36%), Positives = 148/272 (54%), Gaps = 16/272 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI-----RSLDVVGKIKREIQNLK 69 Y++ TLG G G+VK+ + T KVA++I++++K R D ++ EI+ LK Sbjct: 136 EYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILK 195 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 HP IIK+ D+++V+E + GGELFD + + R++E + F Q+L AV Y Sbjct: 196 KLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 254 Query: 130 CHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + ++HRDLKPENVLL + KI DFG S ++ + +RT CG+P Y APEV+ Sbjct: 255 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLV 314 Query: 187 GRLYAG--PEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGGVF-YIPEY---LNR 239 AG VD WS GVIL+ L G PF + K +I G + +IPE ++ Sbjct: 315 SVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSE 374 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 L+ +L VDP R T ++ H W + + Sbjct: 375 KALDLVKKLLVVDPKARFTTEEALRHPWLQDE 406 >2VZ6-A nrPDB Length = 313 Score = 167 bits (422), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 147/261 (56%), Gaps = 10/261 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ L G + A KI+N +K+ + D K++RE + +L +HP+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 82 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS +++ + V+GGELF+ I E +A QQIL AV +CH+ V Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 136 VHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + + K+ADFGL+ + + + G+P Y +PEV+ Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 202 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 203 KP-VDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 248 MLQVDPLKRATIKDIREHEWF 268 ML ++P KR T + +H W Sbjct: 262 MLTINPSKRITAAEALKHPWI 282 >2W4O-A nrPDB Length = 349 Score = 166 bits (421), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 100/256 (39%), Positives = 145/256 (56%), Gaps = 18/256 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G V + + T A+K+L + + + ++ EI L HP+IIKL + Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGVLLRLSHPNIIKLKE 115 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 + TPT+ +V+E V+GGELFD I + G E +A +QIL AV Y H + +VHRDLK Sbjct: 116 IFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLK 175 Query: 142 PENVLL-----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 PEN+L DA + KIADFGLS ++ ++T CG+P Y APE++ G Y GPEVD Sbjct: 176 PENLLYATPAPDAPL--KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY-GPEVD 232 Query: 197 IWSCGVILYALLCGTLPFDDEHVPT-LFKKIRGGVFYI--PEY--LNRSVATLLMHMLQV 251 +WS G+I Y LLCG PF DE +F++I +Y P + ++ + L+ ++ + Sbjct: 233 MWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVL 292 Query: 252 DPLKRATIKDIREHEW 267 DP KR T +H W Sbjct: 293 DPKKRLTTFQALQHPW 308 >5X3F-B nrPDB Length = 393 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 88/253 (34%), Positives = 143/253 (56%), Gaps = 8/253 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 TLG G+FG+V + +H+ +G+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 91 TLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 150 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 ++ +MVMEYV+GGE+F ++ + GR E AR QI+ +Y H +++RDL Sbjct: 151 FSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 210 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 KPEN+L+D ++ DFG + + + T CG+P Y APE+I + Y VD W+ Sbjct: 211 KPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY-NKAVDWWAL 267 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR---- 256 GV++Y + G PF + +++KI G P + + + LL ++LQVD KR Sbjct: 268 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 327 Query: 257 -ATIKDIREHEWF 268 + DI+ H+WF Sbjct: 328 KNGVNDIKNHKWF 340 >4WB7-A nrPDB Length = 405 Score = 165 bits (418), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 89/253 (35%), Positives = 142/253 (56%), Gaps = 8/253 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + L+ P ++KL Sbjct: 103 TLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLE 162 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 ++ +MVMEYV GGE+F ++ + GR E AR QI+ +Y H +++RDL Sbjct: 163 FSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 222 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 KPEN+L+D ++ DFG + + + T CG+P Y APE+I + Y VD W+ Sbjct: 223 KPENLLIDQQGYIQVTDFGFAKRVKGRTW--TLCGTPEYLAPEIILSKGY-NKAVDWWAL 279 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR---- 256 GV++Y + G PF + +++KI G P + + + LL ++LQVD KR Sbjct: 280 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 339 Query: 257 -ATIKDIREHEWF 268 + DI+ H+WF Sbjct: 340 KNGVNDIKNHKWF 352 >3LIJ-A nrPDB Length = 494 Score = 164 bits (416), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 94/256 (36%), Positives = 143/256 (55%), Gaps = 10/256 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V + ++T + A+KI+ + + S K+ E+ LKL HP+I+KLY Sbjct: 45 LGSGAYGEVLLCRDKVTHVERAIKIIRKTSV-STSSNSKLLEEVAVLKLLDHPNIMKLYD 103 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 ++++VME GGELFD I + E++A + +Q+LS V Y H+H +VHRDLK Sbjct: 104 FFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLK 163 Query: 142 PENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 PEN+LL++ KI DFGLS + + + ++ G+ Y APEV+ R + D+W Sbjct: 164 PENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RKKYDEKCDVW 221 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGG--VFYIPEYLNRS--VATLLMHMLQVDPL 254 S GVIL+ LL G PF + + +K+ G F PE+ N S L+ MLQ D Sbjct: 222 SIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQ 281 Query: 255 KRATIKDIREHEWFKQ 270 +R + + EH W K+ Sbjct: 282 RRISAQQALEHPWIKE 297 >5N23-A nrPDB Length = 352 Score = 164 bits (415), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 89/253 (35%), Positives = 141/253 (55%), Gaps = 7/253 (2%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + + P ++KL Sbjct: 49 TLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLE 108 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 ++ +MV+EY GGE+F ++ + GR E AR QI+ +Y H +++RDL Sbjct: 109 FSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 KPEN+L+D K+ADFG + + G T CG+P Y APE+I + Y VD W+ Sbjct: 169 KPENLLIDQQGYIKVADFGFAKRVK-GRTPWTLCGTPEYLAPEIILSKGY-NKAVDWWAL 226 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR---- 256 GV++Y + G PF + +++KI G P + + + LL ++LQVD KR Sbjct: 227 GVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNL 286 Query: 257 -ATIKDIREHEWF 268 + DI+ H+WF Sbjct: 287 KNGVNDIKNHKWF 299 >3SOA-A nrPDB Length = 444 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 95/261 (36%), Positives = 146/261 (55%), Gaps = 10/261 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ L G + A I+N +K+ + D K++RE + +L +HP+ Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDH-QKLEREARICRLLKHPN 71 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS +++ + V+GGELF+ I E +A QQIL AV +CH+ V Sbjct: 72 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 131 Query: 136 VHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHR+LKPEN+LL + + K+ADFGL+ + + + G+P Y +PEV+ Y Sbjct: 132 VHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 191 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 192 KP-VDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 250 Query: 248 MLQVDPLKRATIKDIREHEWF 268 ML ++P KR T + +H W Sbjct: 251 MLTINPSKRITAAEALKHPWI 271 >5JZN-A nrPDB Length = 280 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 149/264 (56%), Gaps = 19/264 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y +G T+G G F VK + T + A+KI+ + K R + + I+ E+ L+ +HP+ Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKHPN 78 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L + + PT+ ++VME V GG+LFD I + E +A + + SA+ Y H + Sbjct: 79 IVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNI 138 Query: 136 VHRDLKPENVLLDAHMNA----KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRD+KPEN+L+ H + K+ DFGL+ ++ DG L T CG+P Y APE+I+ Y Sbjct: 139 VHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV-DGP-LYTVCGTPTYVAPEIIAETGY- 195 Query: 192 GPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYIP----EYLNRSVAT 243 G +VDIW+ GVI Y LLCG PF DD+ V LF +I G P + ++ S Sbjct: 196 GLKVDIWAAGVITYILLCGFPPFRGSGDDQEV--LFDQILMGQVDFPSPYWDNVSDSAKE 253 Query: 244 LLMHMLQVDPLKRATIKDIREHEW 267 L+ ML VD +R + + EH W Sbjct: 254 LITMMLLVDVDQRFSAVQVLEHPW 277 >1FOT-A nrPDB Length = 318 Score = 162 bits (410), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 85/255 (33%), Positives = 136/255 (53%), Gaps = 8/255 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 TLG G+FG+V + + G A+K+L ++ + L V E L + HP II+++ Sbjct: 13 TLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMW 72 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 FM+M+Y+ GGELF + K R A+ ++ A++Y H +++RDL Sbjct: 73 GTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDL 132 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 KPEN+LLD + + KI DFG + + D + T CG+P+Y APEV+S + Y +D WS Sbjct: 133 KPENILLDKNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVVSTKPY-NKSIDWWSF 189 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR---- 256 G+++Y +L G PF D + ++KI P + N V LL ++ D +R Sbjct: 190 GILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNL 249 Query: 257 -ATIKDIREHEWFKQ 270 +D++ H WFK+ Sbjct: 250 QNGTEDVKNHPWFKE 264 >2V7O-A nrPDB Length = 336 Score = 162 bits (409), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 95/263 (36%), Positives = 145/263 (55%), Gaps = 10/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ + + A KI+N +K+ + D K++RE + +L +HP+ Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 91 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS ++V + V+GGELF+ I E +A QIL +V++ H+H + Sbjct: 92 IVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDI 151 Query: 136 VHRDLKPENVLLDAHMNA---KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + K+ADFGL+ + + + G+P Y +PEV+ Y Sbjct: 152 VHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYG 211 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 P VDIW+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 212 KP-VDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 270 Query: 248 MLQVDPLKRATIKDIREHEWFKQ 270 ML ++P KR T +H W Q Sbjct: 271 MLTINPAKRITADQALKHPWVCQ 293 >3Q5I-A nrPDB Length = 504 Score = 161 bits (408), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 97/277 (35%), Positives = 147/277 (53%), Gaps = 20/277 (7%) Query: 12 KIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI---RSLDVVGKIKR---- 63 KIG Y LG G +G+V + + + + A+K++ + + R D I++ Sbjct: 33 KIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEE 92 Query: 64 ---EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 EI LK HP+IIKL+ V F++V E+ GGELF+ I + +E +A + Sbjct: 93 IYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIM 152 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAH---MNAKIADFGLSNMMSDGEFLRTSCGSP 177 +QILS + Y H+H +VHRD+KPEN+LL+ +N KI DFGLS+ S LR G+ Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTA 212 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP--- 234 Y APEV+ + + D+WSCGVI+Y LLCG PF ++ + KK+ G +Y Sbjct: 213 YYIAPEVLKKKY--NEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFND 270 Query: 235 -EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + ++ L+ ML D KR T ++ W K+ Sbjct: 271 WKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK 307 >2JDO-A nrPDB Length = 342 Score = 161 bits (407), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 98/267 (36%), Positives = 144/267 (53%), Gaps = 7/267 (2%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D +V + + LG GTFGKV + + TG A+KIL ++ I + D V E + Sbjct: 4 DPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 63 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 L+ RHP + L T VMEY +GGELF ++ + E AR +I+SA+ Sbjct: 64 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVIS 186 +Y H VV+RD+K EN++LD + KI DFGL +SDG ++T CG+P Y APEV+ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G VD W GV++Y ++CG LPF ++ LF+ I P L+ +LL Sbjct: 184 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLA 242 Query: 247 HMLQVDPLKR-----ATIKDIREHEWF 268 +L+ DP +R + K++ EH +F Sbjct: 243 GLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >3TXO-A nrPDB Length = 353 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 93/249 (37%), Positives = 138/249 (55%), Gaps = 3/249 (1%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+ I ++ LG G+FGKV + + TG AVK+L + I D V E + L Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 78 Query: 70 LFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L R HP + +L+ TP F VME+V+GG+L +I K R +E AR +I+SA+ Sbjct: 79 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 138 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISG 187 + H +++RDLK +NVLLD + K+ADFG+ + +G T CG+P+Y APE++ Sbjct: 139 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 198 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 LY GP VD W+ GV+LY +LCG PF+ E+ LF+ I P +L+ +L Sbjct: 199 MLY-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 257 Query: 248 MLQVDPLKR 256 + +P R Sbjct: 258 FMTKNPTMR 266 >3MV5-A nrPDB Length = 342 Score = 159 bits (401), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 100/268 (37%), Positives = 142/268 (52%), Gaps = 8/268 (2%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D RV + + LG GTFGKV + + + TG A+KIL ++ I + D V E + Sbjct: 4 DPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 63 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 L+ RHP + L T VMEY +GGELF ++ + E AR +I+SA+ Sbjct: 64 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 128 DYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVI 185 DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 Y G VD W GV++Y ++CG LPF ++ LF+ I P L +LL Sbjct: 184 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 242 Query: 246 MHMLQVDPLKR-----ATIKDIREHEWF 268 +L+ DP +R K+I +H +F Sbjct: 243 SGLLKKDPKQRLGGGSEDAKEIMQHRFF 270 >5KCV-A nrPDB Length = 460 Score = 158 bits (399), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 106/306 (34%), Positives = 157/306 (51%), Gaps = 12/306 (3%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 K KH RV + + LG GTFGKV + + + TG A+KIL ++ I + D V Sbjct: 154 KPKH--RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 211 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 E + L+ RHP + L T VMEY +GGELF ++ + E AR +I Sbjct: 212 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 271 Query: 124 LSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAA 181 +SA+DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y A Sbjct: 272 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 331 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PEV+ Y G VD W GV++Y ++CG LPF ++ LF+ I P L Sbjct: 332 PEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 390 Query: 242 ATLLMHMLQVDPLKR-----ATIKDIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVK 294 +LL +L+ DP +R K+I +H +F + +++ + P + V + + Sbjct: 391 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 450 Query: 295 EVCEKF 300 E+F Sbjct: 451 YFDEEF 456 >2BRG-A nrPDB Length = 297 Score = 157 bits (397), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 91/263 (34%), Positives = 147/263 (55%), Gaps = 8/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + L TLG G +G+V++ +++T VAVKI++ + R++D IK+EI K+ H + Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK--RAVDCPENIKKEICINKMLNHEN 66 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 ++K Y ++ +EY SGGELFD I + E +A+R F Q+++ V Y H + Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISGRLYAG 192 HRD+KPEN+LLD N KI+DFGL+ + + L CG+ Y APE++ R + Sbjct: 127 THRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHA 186 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTL-FKKIRGGVFYIPEY--LNRSVATLLMHML 249 VD+WSCG++L A+L G LP+D + + Y+ + ++ + LL +L Sbjct: 187 EPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKIL 246 Query: 250 QVDPLKRATIKDIREHEWFKQDL 272 +P R TI DI++ W+ + L Sbjct: 247 VENPSARITIPDIKKDRWYNKPL 269 >5FET-A nrPDB Length = 847 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 97/270 (35%), Positives = 146/270 (54%), Gaps = 11/270 (4%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 D +V++ +G GTFG VK+ H+ T + A+K ++++ I SL+ IK E + Sbjct: 526 QDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLERE 585 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 HP II+L + F+ + E V+GGEL+D I K G + + +A+ I+ A Sbjct: 586 ITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILA 645 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 ++Y H +V+RDLKPEN+LLD K+ DFG + + + T G+P+Y APEVI Sbjct: 646 IEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAY--TLVGTPHYMAPEVIL 703 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRGGVFYIPEYL-NRSVAT 243 G+ Y G VDIW+ GV LY +CG LPF D E +F+ I G P+Y+ ++ Sbjct: 704 GKGY-GCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSIN 762 Query: 244 LLMHMLQVDPLKRA-----TIKDIREHEWF 268 L+ +L P R KDI+EH +F Sbjct: 763 LMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >2J90-A nrPDB Length = 304 Score = 155 bits (393), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 92/268 (34%), Positives = 141/268 (52%), Gaps = 16/268 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLF 71 HY +G+ LG G F V+ + TG + A K + ++++ S +I+RE+ L+ Sbjct: 27 HYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREI 86 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 RHP+II L+ + TD +++E VSGGELFD++ + + E EA + +QIL V Y H Sbjct: 87 RHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLH 146 Query: 132 RHMVVHRDLKPENV-LLDAHM---NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 + H DLKPEN+ LLD ++ K+ DFG+++ + G + G+P + APE+++ Sbjct: 147 SKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVN- 205 Query: 188 RLYA--GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF-YIPEYLNRS---V 241 Y G E D+WS GVI Y LL G PF E I + + EY + + Sbjct: 206 --YEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELA 263 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK 269 + +L DP +R TI EH W K Sbjct: 264 KDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >4B8L-A nrPDB Length = 286 Score = 154 bits (390), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 81/262 (30%), Positives = 138/262 (52%), Gaps = 2/262 (0%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + I + +G LG G FG V + + +A+K+L + ++ V +++REI+ Sbjct: 11 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQS 70 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 RHP+I+++Y ++++E+ GEL+ + KHGR +E + +++ A+ Y Sbjct: 71 HLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHY 130 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 CH V+HRD+KPEN+L+ KIADFG S + + RT CG+ +Y PE+I G+ Sbjct: 131 CHERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMIEGKT 189 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHML 249 + +VD+W GV+ Y L G PFD ++I P +L+ L+ +L Sbjct: 190 H-DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLL 248 Query: 250 QVDPLKRATIKDIREHEWFKQD 271 + P +R +K + EH W K + Sbjct: 249 RYHPPQRLPLKGVMEHPWVKAN 270 >5DYK-A nrPDB Length = 853 Score = 154 bits (390), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 95/270 (35%), Positives = 146/270 (54%), Gaps = 11/270 (4%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 D +V++ +G GTFG VK+ H+ T + A+K ++++ I +L+ IK E + Sbjct: 532 QDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLERE 591 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 HP II+L + F+ + E V+GGEL+D I K G + + +A+ I+ A Sbjct: 592 ITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILA 651 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 ++Y H +V+RDLKPEN+LLD K+ DFG + + + T G+P+Y APEVI Sbjct: 652 IEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAY--TLVGTPHYMAPEVIL 709 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRGGVFYIPEYLNRSVATL 244 G+ Y G VDIW+ G+ LY +CG LPF D+E +F+ I G P+Y+ + + Sbjct: 710 GKGY-GCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSIN 768 Query: 245 LMHMLQVD-PLKRA-----TIKDIREHEWF 268 LM L P R KDI++H +F Sbjct: 769 LMKRLLCRLPQGRIGCSINGFKDIKDHPFF 798 >5LOH-A nrPDB Length = 341 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 87/254 (34%), Positives = 143/254 (56%), Gaps = 13/254 (5%) Query: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIS 84 G FGKV +G Q G AVK++ + + + ++ +++ E L L + P I+ LY + Sbjct: 47 GAFGKVYLG--QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQ 104 Query: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 + + ++VMEY+ GG++ + +G +E A + ++ A+DY HRH ++HRDLKP+N Sbjct: 105 SANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDN 164 Query: 145 VLLDAHMNAKIADFGLSNM-------MSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 +L+ + K+ DFGLS + M D RT CG+P+Y APE++ GR + GP VD Sbjct: 165 MLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAH-GPAVDW 223 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP---EYLNRSVATLLMHMLQVDPL 254 W+ GV L+ L G PF+DE +F+ I P E L+ + + + +L +D Sbjct: 224 WALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDT 283 Query: 255 KRATIKDIREHEWF 268 KRA +K+++ H F Sbjct: 284 KRAGMKELKRHPLF 297 >4UZD-A nrPDB Length = 287 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 77/252 (30%), Positives = 138/252 (54%), Gaps = 2/252 (0%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + +G LG G FG V + + + +A+K+L + ++ V +++RE++ RHP+ Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 69 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++LY T ++++EY G ++ + K + +E ++ +A+ YCH V Sbjct: 70 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 129 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 +HRD+KPEN+LL + KIADFG S + + T CG+ +Y PE+I GR++ +V Sbjct: 130 IHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH-DEKV 187 Query: 196 DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 D+WS GV+ Y L G PF+ +K+I F P+++ L+ +L+ +P + Sbjct: 188 DLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQ 247 Query: 256 RATIKDIREHEW 267 R ++++ EH W Sbjct: 248 RPMLREVLEHPW 259 >1PHK-A nrPDB Length = 298 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 99/277 (35%), Positives = 143/277 (51%), Gaps = 26/277 (9%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL------ 68 +Y + LG G V+ H+ T + AVKI++ S E+Q L Sbjct: 18 NYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSA-----EEVQELREATLK 72 Query: 69 ------KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122 K+ HP+II+L T T FF+V + + GELFDY+ + + E E R++ + Sbjct: 73 EVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRA 132 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 +L + H+ +VHRDLKPEN+LLD MN K+ DFG S + GE LR CG+P+Y AP Sbjct: 133 LLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAP 192 Query: 183 EVISGRLY-----AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PE 235 E+I + G EVD+WS GVI+Y LL G+ PF + + I G + PE Sbjct: 193 EIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPE 252 Query: 236 YLNRS--VATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + + S V L+ L V P KR T ++ H +F+Q Sbjct: 253 WDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >3D2K-A nrPDB Length = 272 Score = 153 bits (387), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 78/254 (30%), Positives = 139/254 (54%), Gaps = 2/254 (0%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 +G LG G FG V + + + +A+K+L + ++ V +++RE++ RHP+I+ Sbjct: 16 IGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNIL 75 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 +LY T ++++EY G ++ + K R +E ++ +A+ YCH V+H Sbjct: 76 RLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKRVIH 135 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 RD+KPEN+LL ++ KIADFG S + + T CG+ +Y PE+I GR++ +VD+ Sbjct: 136 RDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH-DEKVDL 193 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRA 257 WS GV+ Y L G PF+ +++I F P+++ L+ +L+ + +R Sbjct: 194 WSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRL 253 Query: 258 TIKDIREHEWFKQD 271 T+ ++ EH W K + Sbjct: 254 TLAEVLEHPWIKAN 267 >3GUB-A nrPDB Length = 295 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 95/266 (35%), Positives = 141/266 (53%), Gaps = 12/266 (4%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLF 71 +Y G+ LG G F VK + TG + A K + +++ +S I+RE+ LK Sbjct: 12 YYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI 71 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 +HP++I L++V TD ++ E V+GGELFD++ + + E EA +QIL+ V Y H Sbjct: 72 QHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLH 131 Query: 132 RHMVVHRDLKPENV-LLDAHM---NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 + H DLKPEN+ LLD ++ KI DFGL++ + G + G+P + APE+++ Sbjct: 132 SLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNY 191 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRSVA---T 243 G E D+WS GVI Y LL G PF D TL + EY + + A Sbjct: 192 EPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKD 250 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFK 269 + +L DP KR TI+D +H W K Sbjct: 251 FIRRLLVKDPKKRMTIQDSLQHPWIK 276 >2WTK-C nrPDB Length = 305 Score = 152 bits (383), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 90/270 (33%), Positives = 150/270 (55%), Gaps = 10/270 (3%) Query: 13 IGHYVLGDTLGVGTFGKVK-IGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 IG Y++GD LG G++GKVK + + + + + ++ R + +K+EIQ L+ Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 72 RHPHIIKLYQVI--STPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAV 127 RH ++I+L V+ +MVMEY G E+ D + + R +A F Q++ + Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 122 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEV 184 +Y H +VH+D+KP N+LL KI+ G++ + + + RTS GSP + PE+ Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 185 ISG-RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 +G ++G +VDIWS GV LY + G PF+ +++ LF+ I G + IP ++ Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 242 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLP 273 LL ML+ +P KR +I+ IR+H WF++ P Sbjct: 243 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 272 >4JXF-A nrPDB Length = 266 Score = 151 bits (381), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 84/262 (32%), Positives = 142/262 (54%), Gaps = 3/262 (1%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 KI + +G+ LG G+F V E TG +VA+K+++++ + +V +++ E++ Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYC 130 +HP I++LY ++V+E GE+ Y+ + E EAR QI++ + Y Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 189 H H ++HRDL N+LL +MN KIADFGL+ + E T CG+PNY +PE I+ R Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRS 183 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHML 249 G E D+WS G + Y LL G PFD + V K+ + +P +L+ L+ +L Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 243 Query: 250 QVDPLKRATIKDIREHEWFKQD 271 + +P R ++ + +H + ++ Sbjct: 244 RRNPADRLSLSSVLDHPFMSRN 265 >4RA4-A nrPDB Length = 355 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 92/268 (34%), Positives = 147/268 (54%), Gaps = 8/268 (2%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 RVK+ + LG G+FGKV + + + T A+KIL + + D V E + L Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 70 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L + P + +L+ T + VMEYV+GG+L +I + G+ +E +A +I + Sbjct: 76 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISG 187 + H+ +++RDLK +NV+LD+ + KIADFG+ M DG RT CG+P+Y APE+I+ Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY 195 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + Y G VD W+ GV+LY +L G PFD E LF+ I P+ L++ ++ Sbjct: 196 QPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 254 Query: 248 MLQVDPLKRATI-----KDIREHEWFKQ 270 ++ P KR +D+REH +F++ Sbjct: 255 LMTKHPAKRLGCGPEGERDVREHAFFRR 282 >5F9E-A nrPDB Length = 353 Score = 147 bits (371), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 90/265 (33%), Positives = 142/265 (53%), Gaps = 6/265 (2%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 ++KI + L LG G+FGKV + E + T A+K L + + D V E + L Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 70 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L + HP + ++ T + F VMEY++GG+L +I + + A +I+ + Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQ 134 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL--SNMMSDGEFLRTSCGSPNYAAPEVIS 186 + H +V+RDLK +N+LLD + KIADFG+ NM+ D + CG+P+Y APE++ Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAK-TNEFCGTPDYIAPEILL 193 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 G+ Y VD WS GV+LY +L G PF + LF IR + P +L + LL+ Sbjct: 194 GQKY-NHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLV 252 Query: 247 HMLQVDPLKRATIK-DIREHEWFKQ 270 + +P KR ++ DIR+H F++ Sbjct: 253 KLFVREPEKRLGVRGDIRQHPLFRE 277 >6CMJ-A nrPDB Length = 321 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 82/272 (30%), Positives = 147/272 (54%), Gaps = 16/272 (5%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK--------IRSLDVVGKIK 62 V++ Y L D +G G++G VK+ ++ A+K+L+++K I+ + ++ Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 63 REIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 +EI LK HP+++KL +V+ P + +MV E V+ G + + + + E +AR F Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYF 149 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-FLRTSCGSPNY 179 Q ++ ++Y H ++HRD+KP N+L+ + KIADFG+SN + L + G+P + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 180 AAPEVISG--RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY- 236 APE +S ++++G +D+W+ GV LY + G PF DE + L KI+ P+ Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQP 269 Query: 237 -LNRSVATLLMHMLQVDPLKRATIKDIREHEW 267 + + L+ ML +P R + +I+ H W Sbjct: 270 DIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 301 >2YAB-A nrPDB Length = 361 Score = 145 bits (367), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 90/263 (34%), Positives = 140/263 (53%), Gaps = 12/263 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLFR 72 Y +G+ LG G F VK + TG + A K + +++ R+ +I+RE+ L+ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+II L+ V TD +++E VSGGELFD++ + + E EA +QIL V+Y H Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 133 HMVVHRDLKPENV-LLDAHM---NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 + H DLKPEN+ LLD ++ + K+ DFGL++ + DG + G+P + APE+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE 193 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRS---VATL 244 G E D+WS GVI Y LL G PF D TL + E+ +++ Sbjct: 194 PL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDF 252 Query: 245 LMHMLQVDPLKRATIKDIREHEW 267 + +L + KR TI++ H W Sbjct: 253 IRKLLVKETRKRLTIQEALRHPW 275 >3IS5-A nrPDB Length = 285 Score = 145 bits (365), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 91/268 (33%), Positives = 136/268 (50%), Gaps = 20/268 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++ LG G FG V + E + +G + +K +N+ RS + +I+ EI+ LK HP+ Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD--RSQVPMEQIEAEIEVLKSLDHPN 81 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYI----CKHGRVEEMEARRLFQQILSAVDYCH 131 IIK+++V + ++VME GGEL + I + + E L +Q+++A+ Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 132 RHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 VVH+DLKPEN+L H KI DFGL+ + E + G+ Y APEV Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRD 201 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY------LNRSVA 242 + + DIWS GV++Y LL G LPF + + +K + P Y L Sbjct: 202 VTF--KCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQK---ATYKEPNYAVECRPLTPQAV 256 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFKQ 270 LL ML DP +R + + HEWFKQ Sbjct: 257 DLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >3KN6-A nrPDB Length = 325 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 91/264 (34%), Positives = 144/264 (54%), Gaps = 23/264 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHIIKLY 80 LG G+F + H+ + AVKI++++ + ++EI LKL HP+I+KL+ Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKR------MEANTQKEITALKLCEGHPNIVKLH 72 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 +V F+VME ++GGELF+ I K E EA + ++++SAV + H VVHRDL Sbjct: 73 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 132 Query: 141 KPENVLL---DAHMNAKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 KPEN+L + ++ KI DFG + + D + L+T C + +YAAPE+++ Y D Sbjct: 133 KPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGY-DESCD 191 Query: 197 IWSCGVILYALLCGTLPFDDE-------HVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 +WS GVILY +L G +PF + KKI+ G F + +++ L+ Sbjct: 192 LWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLI 251 Query: 246 MHMLQVDPLKRATIKDIREHEWFK 269 +L VDP KR + +R +EW + Sbjct: 252 QGLLTVDPNKRLKMSGLRYNEWLQ 275 >4I6B-A nrPDB Length = 308 Score = 141 bits (355), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 81/257 (31%), Positives = 133/257 (51%), Gaps = 4/257 (1%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKV-AVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y G TLG G F K LT +KV A KI+ ++ KI +EI+ ++ H Sbjct: 30 YSRGKTLGKGGFAKC-YEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 H+++ Y + ++++EY S + + + E E R +QI+S + Y H Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVISGRLYAGP 193 ++HRDLK N ++ M K+ DFGL+ + E RT CG+PNY +PEV++ + + G Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH-GA 207 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 253 E DIW+ G ++Y +L G PF+ ++ ++ IR + +P L L+ ML +P Sbjct: 208 ESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNP 267 Query: 254 LKRATIKDIREHEWFKQ 270 R ++ DI H++F Q Sbjct: 268 EDRPSLDDIIRHDFFTQ 284 >6FDY-U nrPDB Length = 276 Score = 141 bits (355), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 91/265 (34%), Positives = 138/265 (52%), Gaps = 8/265 (3%) Query: 9 GRVKIGHYVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 G ++ ++L + LG GT+ V K + T VA+K + ++ + V + EI+ Sbjct: 6 GPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLT-EIEI 64 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 LK RHPHI++L + +++ME+ +GG+L +I + E AR QQ+ SA+ Sbjct: 65 LKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASAL 124 Query: 128 DYCHRHMVVHRDLKPENVLLDA--HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + H + H DLKP+N+LL + + K+ADFG + MS + GSP Y APE++ Sbjct: 125 QFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV 184 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG-VFYIP--EYLNRSVA 242 R Y VD+WS GVILY L G PF L +KIR V +P L+R Sbjct: 185 CQRQYDA-RVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCR 243 Query: 243 TLLMHMLQVDPLKRATIKDIREHEW 267 LL +L+ DP +R + +D H W Sbjct: 244 DLLQRLLERDPSRRISFQDFFAHPW 268 >5YV8-A nrPDB Length = 298 Score = 141 bits (355), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 82/287 (28%), Positives = 147/287 (51%), Gaps = 31/287 (10%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK------------------- 51 V++ Y L D +G G++G VK+ ++ A+K+L+++K Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 52 ----IRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYI 105 I+ + ++ +EI LK HP+++KL +V+ P + +MV E V+ G + + + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 128 Query: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165 + E +AR FQ ++ ++Y H ++HRD+KP N+L+ + KIADFG+SN Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 166 DGE-FLRTSCGSPNYAAPEVISG--RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 + L + G+P + APE +S ++++G +D+W+ GV LY + G PF DE + L Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 248 Query: 223 FKKIRGGVFYIPEY--LNRSVATLLMHMLQVDPLKRATIKDIREHEW 267 KI+ P+ + + L+ ML +P R + +I+ H W Sbjct: 249 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 295 >2A27-A nrPDB Length = 321 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 90/263 (34%), Positives = 140/263 (53%), Gaps = 12/263 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-SLDVVGK--IKREIQNLKLFR 72 Y +G+ LG G F VK + TG + A K + +++ R S V + I+RE+ L+ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H ++I L+ V TD +++E VSGGELFD++ + + E EA +QIL V+Y H Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 133 HMVVHRDLKPENV-LLDAHM---NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 + H DLKPEN+ LLD ++ + K+ DFGL++ + DG + G+P + APE+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE 193 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRS---VATL 244 G E D+WS GVI Y LL G PF D TL + E+ +++ Sbjct: 194 PL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDF 252 Query: 245 LMHMLQVDPLKRATIKDIREHEW 267 + +L + KR TI++ H W Sbjct: 253 IRKLLVKETRKRLTIQEALRHPW 275 >1ZWS-A nrPDB Length = 288 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 90/263 (34%), Positives = 139/263 (52%), Gaps = 12/263 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-SLDVVGK--IKREIQNLKLFR 72 Y +G+ LG G F VK + TG + A K + +++ R S V + I+RE+ L+ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H ++I L+ V TD +++E VSGGELFD++ + + E EA +QIL V+Y H Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 133 HMVVHRDLKPENV-LLDAHM---NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 + H DLKPEN+ LLD ++ + K+ DFGL++ + DG + G+P + APE+++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE 193 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRS---VATL 244 G E D+WS GVI Y LL G PF D TL + E+ + + Sbjct: 194 PL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAKDF 252 Query: 245 LMHMLQVDPLKRATIKDIREHEW 267 + +L + KR TI++ H W Sbjct: 253 IRKLLVKETRKRLTIQEALRHPW 275 >2OU7-A nrPDB Length = 335 Score = 139 bits (349), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 83/248 (33%), Positives = 127/248 (51%), Gaps = 2/248 (0%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G F K T A KI+ + + K+ EI + H H++ + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 F+V+E L + + + E EAR +QI+ Y HR+ V+HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 142 PENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 N+ L+ + KI DFGL+ + DGE + CG+PNY APEV+S + ++ EVD+WS Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSF-EVDVWSI 227 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 G I+Y LL G PF+ + + +I+ + IP+++N A+L+ MLQ DP R TI Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 287 Query: 261 DIREHEWF 268 ++ E+F Sbjct: 288 ELLNDEFF 295 >3TAC-A nrPDB Length = 361 Score = 139 bits (349), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 89/269 (33%), Positives = 140/269 (52%), Gaps = 16/269 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK--IKREIQNLKLFRH 73 Y L + +G G F V+ ++ TG + AVKI++ K S + +KRE + +H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV----EEMEARRLFQQILSAVDY 129 PHI++L + S+ +MV E++ G +L I K E A +QIL A+ Y Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 130 CHRHMVVHRDLKPENVLLDAHMNA---KIADFGLSNMMSD-GEFLRTSCGSPNYAAPEVI 185 CH + ++HRD+KP VLL + N+ K+ FG++ + + G G+P++ APEV+ Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV 207 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSV 241 Y P VD+W CGVIL+ LL G LPF LF+ I G + + +++ S Sbjct: 208 KREPYGKP-VDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHISESA 265 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 L+ ML +DP +R T+ + H W K+ Sbjct: 266 KDLVRRMLMLDPAERITVYEALNHPWLKE 294 >3PFQ-A nrPDB Length = 674 Score = 139 bits (349), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 142/267 (53%), Gaps = 8/267 (2%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 70 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 397 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISG 187 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 516 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 517 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 575 Query: 248 MLQVDPLKRATI-----KDIREHEWFK 269 ++ P KR +DI+EH +F+ Sbjct: 576 LMTKHPGKRLGCGPEGERDIKEHAFFR 602 >6BDL-A nrPDB Length = 347 Score = 138 bits (348), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 85/269 (31%), Positives = 143/269 (53%), Gaps = 13/269 (4%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKV-AVKILNRQKIRSLDVVGKIKREIQNLK 69 +K+ + + DTLGVG FG+V++ + + K A+KIL ++ I I+ E Q ++ Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 I++LY+ +M+ME GGEL+ + G E+ R ++ A Y Sbjct: 91 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 H +++RDLKPEN++LD AK+ DFG + + G+ T CG+P Y APE+I L Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII---L 207 Query: 190 YAGPEV--DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEYLNRSVATLL 245 G ++ D WS G+++Y LL G+ PF + I G+ I P+ + ++ A L+ Sbjct: 208 NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLI 267 Query: 246 MHMLQVDPLKR-----ATIKDIREHEWFK 269 + + +P +R +KDI++H+WF+ Sbjct: 268 KKLCRDNPSERLGNLKNGVKDIQKHKWFE 296 >4C0T-A nrPDB Length = 974 Score = 138 bits (348), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 81/271 (29%), Positives = 135/271 (49%), Gaps = 12/271 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL- 68 R + + G LG G++ V + ++TG + AVK+L+++ I V + E L Sbjct: 262 RRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN 321 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +L +I LY + V++Y S GEL I ++ + E R QIL A+ Sbjct: 322 RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-----EF-----LRTSCGSPN 178 Y H + V+HRDLKPEN+LLD M +I DFG + ++ E+ ++ G+ Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Y +PE++ + Y G D+W+ G I+Y ++ G PF + F+KI F Sbjct: 442 YVSPELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFP 500 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + L+ +L + P +RATI +I++H +F+ Sbjct: 501 TIIRDLIKKILVLQPSRRATIPEIQKHYFFQ 531 >2I0E-A nrPDB Length = 353 Score = 138 bits (348), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 142/267 (53%), Gaps = 8/267 (2%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 70 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 76 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISG 187 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 195 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 196 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 254 Query: 248 MLQVDPLKRATI-----KDIREHEWFK 269 ++ P KR +DI+EH +F+ Sbjct: 255 LMTKHPGKRLGCGPEGERDIKEHAFFR 281 >4J52-A nrPDB Length = 293 Score = 137 bits (346), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 83/248 (33%), Positives = 127/248 (51%), Gaps = 2/248 (0%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G F K T A KI+ + + K+ EI + H H++ + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 F+V+E L + + + E EAR +QI+ Y HR+ V+HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 142 PENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 N+ L+ + KI DFGL+ + DGE + CG+PNY APEV+S + ++ EVD+WS Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSF-EVDVWSI 200 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 G I+Y LL G PF+ + + +I+ + IP+++N A+L+ MLQ DP R TI Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 260 Query: 261 DIREHEWF 268 ++ E+F Sbjct: 261 ELLNDEFF 268 >4B6L-A nrPDB Length = 281 Score = 137 bits (344), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 80/256 (31%), Positives = 128/256 (50%), Gaps = 2/256 (0%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y+ G LG G F + TG AVK++ + ++ KI EI+ + +H H Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++ + ++ +E S L + E E R +QILS + Y H+ + Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-FLRTSCGSPNYAAPEVISGRLYAGPE 194 +HRDLK N + +M K+ DFGL+ + E +T CG+PNY APEV+ R GPE Sbjct: 131 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPE 189 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPL 254 D+WS G ++Y LLCG+ PF+ + ++ I+ + +P L+ LL +L+ P Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 249 Query: 255 KRATIKDIREHEWFKQ 270 R +I I H++F + Sbjct: 250 DRPSIDQILRHDFFTK 265 >4AF3-A nrPDB Length = 292 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 80/266 (30%), Positives = 136/266 (51%), Gaps = 2/266 (0%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 I + +G LG G FG V + + + VA+K+L + +I V +++REI+ Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+I++LY ++++EY GEL+ + K +E + +++ A+ YCH Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHG 141 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 V+HRD+KPEN+LL KIADFG S + + +T CG+ +Y PE+I GR++ Sbjct: 142 KKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGRMH-N 199 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 +VD+W GV+ Y LL G PF+ +++I P + L+ +L+ + Sbjct: 200 EKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHN 259 Query: 253 PLKRATIKDIREHEWFKQDLPSYLFP 278 P +R + + H W + + L P Sbjct: 260 PSERLPLAQVSAHPWVRANSRRVLPP 285 >3DB8-A nrPDB Length = 317 Score = 136 bits (342), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 127/254 (50%), Gaps = 2/254 (0%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y+ G LG G F K T A K++ + + K+ EI K +PH Sbjct: 44 YMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPH 103 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 ++ + ++V+E L + + V E EAR +Q + V Y H + V Sbjct: 104 VVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRV 163 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 +HRDLK N+ L+ M+ KI DFGL+ + DGE + CG+PNY APEV+ + ++ E Sbjct: 164 IHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSF-E 222 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPL 254 VDIWS G ILY LL G PF+ + + +I+ + +P ++N + L+ ML DP Sbjct: 223 VDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPT 282 Query: 255 KRATIKDIREHEWF 268 R ++ ++ E+F Sbjct: 283 LRPSVAELLTDEFF 296 >3DLS-A nrPDB Length = 335 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 83/266 (31%), Positives = 138/266 (51%), Gaps = 14/266 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV-----GKIKREIQNLKLFRHPHI 76 LG G FG V + +V VK + ++K+ + GK+ EI L H +I Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 77 IKLYQVISTPTDFFMVME-YVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 IK+ + F +VME + SG +LF +I +H R++E A +F+Q++SAV Y + Sbjct: 92 IKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDI 151 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 +HRD+K EN+++ K+ DFG + + G+ T CG+ Y APEV+ G Y GPE+ Sbjct: 152 IHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPEL 211 Query: 196 DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 ++WS GV LY L+ PF + ++ + P +++ + +L+ +LQ P + Sbjct: 212 EMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLVSGLLQPVPER 265 Query: 256 RATIKDIREHEWFKQ--DLPSYLFPE 279 R T++ + W Q +L Y + E Sbjct: 266 RTTLEKLVTDPWVTQPVNLADYTWEE 291 >4NIF-A nrPDB Length = 333 Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 87/267 (32%), Positives = 136/267 (50%), Gaps = 19/267 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 YV+ +T+GVG++ + K H+ T + AVK++++ K + + + L+ +HP+ Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL------LRYGQHPN 63 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 II L V ++V E + GGEL D I + E EA + I V+Y H V Sbjct: 64 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 123 Query: 136 VHRDLKPENVL-LDAHMNA---KIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLY 190 VHRDLKP N+L +D N +I DFG + + ++ L T C + N+ APEV+ + Y Sbjct: 124 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 183 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPT---LFKKIRGGVFYIP----EYLNRSVAT 243 DIWS G++LY +L G PF + T + +I G F + ++ + Sbjct: 184 -DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 242 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQ 270 L+ ML VDP +R T K + +H W Q Sbjct: 243 LVSKMLHVDPHQRLTAKQVLQHPWVTQ 269 >6QAU-A nrPDB Length = 280 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 75/205 (36%), Positives = 110/205 (53%), Gaps = 13/205 (6%) Query: 20 DTLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 D +G G F V G H Q T +VA+K +N++ + ++ + +EI+ LK +H +I+ Sbjct: 17 DLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILKELQHENIVA 74 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 LY V P F+VMEY +GG+L DY+ G + E R QI +A+ H ++HR Sbjct: 75 LYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHR 134 Query: 139 DLKPENVLLD---------AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 DLKP+N+LL + + KIADFG + + CGSP Y APEVI + Sbjct: 135 DLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMSQH 194 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF 214 Y + D+WS G ++Y L G PF Sbjct: 195 YDA-KADLWSIGTVIYQCLVGKPPF 218 >3HDN-A nrPDB Length = 373 Score = 131 bits (329), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 105/344 (30%), Positives = 161/344 (46%), Gaps = 27/344 (7%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KLFRHPHIIKL 79 +G G+FGKV + H+ AVK+L ++ I I E L K +HP ++ L Sbjct: 45 VIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGL 104 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 + T + V++Y++GGELF ++ + E AR +I SA+ Y H +V+RD Sbjct: 105 HFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRD 164 Query: 140 LKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 LKPEN+LLD+ + + DFGL + T CG+P Y APEV+ + Y VD W Sbjct: 165 LKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR-TVDWW 223 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRAT 258 G +LY +L G PF + ++ I + + S LL +LQ D KR Sbjct: 224 CLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLG 283 Query: 259 IKD----IREHEWFK----QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 KD I+ H +F DL + P ++ NV ++ +F TE V N+ Sbjct: 284 AKDDFMEIKSHVFFSLINWDDLINKKI--TPPFNPNVSGPNDLRHFDPEF--TEEPVPNA 339 Query: 311 LYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASS--PPSGSFM 352 + G D + V + +A+E +L S PP+ SF+ Sbjct: 340 I--GKAPDSVLVTAS--------VKEAAEAFLGFSYAPPTDSFL 373 >1KOA-A nrPDB Length = 491 Score = 131 bits (329), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 76/263 (28%), Positives = 130/263 (49%), Gaps = 11/263 (4%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + HY + + LG G FG V + TG+ A K + + V ++EIQ + + R Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETV---RKEIQTMSVLR 106 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDYCH 131 HP ++ L+ + M+ E++SGGELF+ + +H ++ E EA +Q+ + + H Sbjct: 107 HPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 166 Query: 132 RHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 + VH DLKPEN++ + K+ DFGL+ + + ++ + G+ +AAPEV G+ Sbjct: 167 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKP 226 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT----LL 245 G D+WS GV+ Y LL G PF E+ + ++ + + + ++ + Sbjct: 227 -VGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFI 285 Query: 246 MHMLQVDPLKRATIKDIREHEWF 268 +L DP R TI EH W Sbjct: 286 RKLLLADPNTRMTIHQALEHPWL 308 >3UTO-A nrPDB Length = 573 Score = 131 bits (329), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 76/263 (28%), Positives = 130/263 (49%), Gaps = 11/263 (4%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + HY + + LG G FG V + TG+ A K + + V ++EIQ + + R Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETV---RKEIQTMSVLR 212 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDYCH 131 HP ++ L+ + M+ E++SGGELF+ + +H ++ E EA +Q+ + + H Sbjct: 213 HPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 272 Query: 132 RHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 + VH DLKPEN++ + K+ DFGL+ + + ++ + G+ +AAPEV G+ Sbjct: 273 ENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKP 332 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT----LL 245 G D+WS GV+ Y LL G PF E+ + ++ + + + ++ + Sbjct: 333 -VGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFI 391 Query: 246 MHMLQVDPLKRATIKDIREHEWF 268 +L DP R TI EH W Sbjct: 392 RKLLLADPNTRMTIHQALEHPWL 414 >1NY3-A nrPDB Length = 400 Score = 131 bits (329), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 99/313 (31%), Positives = 151/313 (48%), Gaps = 35/313 (11%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 75 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 Query: 76 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 129 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 130 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE----YLN 238 Y D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 237 PEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ KE E Sbjct: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL-----KEDKE 347 Query: 299 KFECTESEVMNSL 311 ++E + E+ ++L Sbjct: 348 RWEDVKEEMTSAL 360 >2OZA-A nrPDB Length = 356 Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 99/313 (31%), Positives = 151/313 (48%), Gaps = 35/313 (11%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 75 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 21 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 72 Query: 76 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 129 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 130 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 192 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE----YLN 238 Y D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 193 PEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 251 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ KE E Sbjct: 252 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL-----KEDKE 303 Query: 299 KFECTESEVMNSL 311 ++E + E+ ++L Sbjct: 304 RWEDVKEEMTSAL 316 >4EAL-A nrPDB Length = 106 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 60/75 (80%), Positives = 68/75 (90%) Query: 400 AKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYL 459 AKWHLGIRSQS+P DIMAEV RA+KQLD+EWKVVN Y+LRVRRKNPVT + KMSLQLY Sbjct: 6 AKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQ 65 Query: 460 VDNRSYLLDFKSIDD 474 VD+R+YLLDF+SIDD Sbjct: 66 VDSRTYLLDFRSIDD 80 Score = 33.5 bits (75), Expect = 0.27, Method: Compositional matrix adjust. Identities = 13/19 (68%), Positives = 17/19 (89%) Query: 534 SHTMDFFEMCASLITTLAR 552 SHT++FFEMCA+LI LA+ Sbjct: 88 SHTIEFFEMCANLIKILAQ 106 >2X4F-A nrPDB Length = 373 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 76/199 (38%), Positives = 108/199 (54%), Gaps = 9/199 (4%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G FG+V E TG K+A KI+ K R + ++K EI + H ++I+L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKII---KTRGMKDKEEVKNEISVMNQLDHANLIQL 151 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHMVVHR 138 Y + D +VMEYV GGELFD I + E++ +QI + + H+ ++H Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHL 211 Query: 139 DLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 DLKPEN+L DA KI DFGL+ E L+ + G+P + APEV++ + P Sbjct: 212 DLKPENILCVNRDAK-QIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFP-T 269 Query: 196 DIWSCGVILYALLCGTLPF 214 D+WS GVI Y LL G PF Sbjct: 270 DMWSVGVIAYMLLSGLSPF 288 >2Z7Q-A nrPDB Length = 321 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 81/250 (32%), Positives = 135/250 (54%), Gaps = 14/250 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQL---TGHKVAVKILNRQKIRSLDVV-GKIKREIQNLKL 70 H+ L LG G+FGKV + +GH A+K+L + ++ D V K++R+I L Sbjct: 29 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDI--LAD 86 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 HP ++KL+ T +++++++ GG+LF + K E + + ++ +D+ Sbjct: 87 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 146 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRL 189 H +++RDLKPEN+LLD + K+ DFGLS D E S CG+ Y APEV++ R Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN-RQ 205 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 D WS GV+++ +L G+LPF D + TL K + G +P++L+ +LL Sbjct: 206 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLG---MPQFLSTEAQSLLR 262 Query: 247 HMLQVDPLKR 256 + + +P R Sbjct: 263 ALFKRNPANR 272 >4WNO-A nrPDB Length = 287 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 80/207 (38%), Positives = 113/207 (54%), Gaps = 17/207 (8%) Query: 20 DTLGVGTFGKVKIGEHQLTGH--KVAVKILNRQKI-RSLDVVGKIKREIQNLKLFRHPHI 76 D +G G F V G H+ H +VAVK +N++ + +S ++GK EI+ LK +H +I Sbjct: 24 DLIGHGAFAVVFKGRHR-AAHDLEVAVKCINKKNLAKSQTLLGK---EIKILKELKHENI 79 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 + LY ++VMEY +GG+L DY+ + E R QQI A+ H ++ Sbjct: 80 VALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGII 139 Query: 137 HRDLKPENVLLD------AHMNA---KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 HRDLKP+N+LL A+ N+ KIADFG + + T CGSP Y APEVI Sbjct: 140 HRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS 199 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF 214 + Y G + D+WS G I+Y L G PF Sbjct: 200 QHYDG-KADLWSIGTIVYQCLTGKAPF 225 >5D9K-A nrPDB Length = 330 Score = 129 bits (324), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 88/279 (31%), Positives = 150/279 (53%), Gaps = 28/279 (10%) Query: 11 VKIGH-------YVLGDTLGVGTFGKVKIGEHQLTGHKV----AVKILNRQKIRSLDVV- 58 VK GH + L LG G+FGKV + + +++G A+K+L + ++ D V Sbjct: 20 VKEGHEKADPSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVR 78 Query: 59 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 118 K++R+I L HP I+KL+ T +++++++ GG+LF + K E + + Sbjct: 79 TKMERDI--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 136 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSP 177 ++ A+D+ H +++RDLKPEN+LLD + K+ DFGLS D E S CG+ Sbjct: 137 YLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTV 196 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIP 234 Y APEV++ R + D WS GV+++ +L GTLPF D + T+ K + G +P Sbjct: 197 EYMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLG---MP 252 Query: 235 EYLNRSVATLLMHMLQVDPLKRA-----TIKDIREHEWF 268 ++L+ +LL + + +P R +++I+ H +F Sbjct: 253 QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF 291 >4FR4-A nrPDB Length = 384 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 75/254 (29%), Positives = 130/254 (51%), Gaps = 11/254 (4%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V H+ + +G G+FGKV I + T A+K +N+QK + V + +E+Q ++ Sbjct: 12 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 71 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 HP ++ L+ D FMV++ + GG+L ++ ++ +E + +++ A+DY Sbjct: 72 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYL 131 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP+N+LLD H + I DF ++ M+ + T G+ Y APE+ S R Sbjct: 132 QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKG 191 Query: 191 AGPE--VDIWSCGVILYALLCGTLPFDDEHVPT------LFKKIRGGVFYIPEYLNRSVA 242 AG VD WS GV Y LL G P+ H+ + + V P ++ + Sbjct: 192 AGYSFAVDWWSLGVTAYELLRGRRPY---HIRSSTSSKEIVHTFETTVVTYPSAWSQEMV 248 Query: 243 TLLMHMLQVDPLKR 256 +LL +L+ +P +R Sbjct: 249 SLLKKLLEPNPDQR 262 >3KA0-A nrPDB Length = 320 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 98/313 (31%), Positives = 150/313 (47%), Gaps = 35/313 (11%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 75 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 19 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 70 Query: 76 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 129 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 71 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 130 Query: 130 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + HRD+KPEN+L + NA K+ DFG + + L C +P Y APEV+ Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLG 190 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE----YLN 238 Y D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 191 PEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 249 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ KE E Sbjct: 250 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL-----KEDKE 301 Query: 299 KFECTESEVMNSL 311 ++E + E+ ++L Sbjct: 302 RWEDVKEEMTSAL 314 >1KOB-A nrPDB Length = 387 Score = 128 bits (321), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 80/264 (30%), Positives = 129/264 (48%), Gaps = 11/264 (4%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y + + LG G FG V + TG K +N LD +K EI + HP Sbjct: 52 YYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTP--YPLDKY-TVKNEISIMNQLHHP 108 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRH 133 +I L+ + +++E++SGGELFD I ++ E E +Q + + H H Sbjct: 109 KLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 134 MVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +VH D+KPEN++ + + KI DFGL+ ++ E ++ + + +AAPE++ R Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVD-REPV 227 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA----TLLMH 247 G D+W+ GV+ Y LL G PF E + ++ + E SV+ + + Sbjct: 228 GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKN 287 Query: 248 MLQVDPLKRATIKDIREHEWFKQD 271 +LQ +P KR T+ D EH W K D Sbjct: 288 LLQKEPRKRLTVHDALEHPWLKGD 311 >6CCF-A nrPDB Length = 290 Score = 127 bits (318), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 119/215 (55%), Gaps = 8/215 (3%) Query: 60 KIKREIQNLKLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEAR 117 ++ +EI LK H +++KL +V+ P + ++V + + G + + C EE +AR Sbjct: 74 RVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEE-QAR 132 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGS 176 + ++ ++Y H +VHRD+KP N+LL + KIADFG+SN + L ++ G+ Sbjct: 133 LYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGT 192 Query: 177 PNYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP 234 P + APE I SG+ ++G +D+W+ GV LY + G PF D+ + L +KI+ P Sbjct: 193 PAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFP 252 Query: 235 E--YLNRSVATLLMHMLQVDPLKRATIKDIREHEW 267 E ++ + L++ ML +P R + DI+ H W Sbjct: 253 EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPW 287 >3ORZ-A nrPDB Length = 316 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 123/244 (50%), Gaps = 4/244 (1%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + G LG G+F V + T + A+KIL ++ I + V + RE + HP Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 +KLY + + Y GEL YI K G +E R +I+SA++Y H + Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGI 158 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTS--CGSPNYAAPEVISGRLYAG 192 +HRDLKPEN+LL+ M+ +I DFG + ++S + + R + G+ Y +PE+++ + A Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK-SAC 217 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 D+W+ G I+Y L+ G PF + +F+KI + PE L+ +L +D Sbjct: 218 KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLD 277 Query: 253 PLKR 256 KR Sbjct: 278 ATKR 281 >4JG6-A nrPDB Length = 355 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 90/274 (32%), Positives = 133/274 (48%), Gaps = 21/274 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y + + +GVG++ K H+ T + AVKI+++ K + + + L+ +HP+ Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEIL------LRYGQHPN 90 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 II L V ++V E + GGEL D I + E EA + I V+Y H V Sbjct: 91 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 150 Query: 136 VHRDLKPENVL-LDAHMN---AKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLY 190 VHRDLKP N+L +D N +I DFG + + ++ L T C + N+ APEV+ + Y Sbjct: 151 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGY 210 Query: 191 AGPEVDIWSCGVILYALLCGTLPFD---DEHVPTLFKKIRGGVFYIPEYLNRSVA----T 243 DIWS GV+LY +L G PF D+ + +I G F + SV+ Sbjct: 211 DAA-CDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKD 269 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQ--DLPSY 275 L+ ML VDP +R T + H W LP Y Sbjct: 270 LVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQY 303 >3LM0-A nrPDB Length = 327 Score = 125 bits (315), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 91/286 (31%), Positives = 138/286 (48%), Gaps = 14/286 (4%) Query: 16 YVL-GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 Y+L LG G F V+ + TG + A K L +++ R D +I EI L+L + Sbjct: 30 YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILHEIAVLELAKSC 88 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVDYCH 131 P +I L++V ++ +++EY +GGE+F V E + RL +QIL V Y H Sbjct: 89 PRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLH 148 Query: 132 RHMVVHRDLKPENVLLDAHM---NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 ++ +VH DLKP+N+LL + + KI DFG+S + LR G+P Y APE+++ Sbjct: 149 QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYD 208 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248 D+W+ G+I Y LL T PF E + I E SV+ L Sbjct: 209 PITTA-TDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDF 267 Query: 249 LQV----DPLKRATIKDIREHEWFKQ-DLPSYLFPEDPSYDANVID 289 +Q +P KR T + H W +Q D + PE+ S + D Sbjct: 268 IQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQD 313 >3FXW-A nrPDB Length = 336 Score = 125 bits (314), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 90/288 (31%), Positives = 138/288 (47%), Gaps = 31/288 (10%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI-QNLKLFRHPHIIKLY 80 LG+G GKV H+ TG K A+K+L K ++E+ + + PHI+ + Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSP--------KARQEVDHHWQASGGPHIVCIL 88 Query: 81 QVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDYCHRHM 134 V ++ME + GGELF I + G E EA + + I +A+ + H H Sbjct: 89 DVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHN 148 Query: 135 VVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 + HRD+KPEN+L + K+ DFG + + L+T C +P Y APEV+ Y Sbjct: 149 IAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA-LQTPCYTPYYVAPEVLGPEKY- 206 Query: 192 GPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYIPE----YLNRSVAT 243 D+WS GVI+Y LLCG PF P + ++IR G + P ++ Sbjct: 207 DKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQ 266 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDE 291 L+ +L+ DP +R TI H W Q S + P+ P + A V+ ++ Sbjct: 267 LIRLLLKTDPTERLTITQFMNHPWINQ---SMVVPQTPLHTARVLQED 311 >3A8W-A nrPDB Length = 345 Score = 125 bits (314), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 139/267 (52%), Gaps = 18/267 (6%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KLFRHPHIIKL 79 +G G++ KV + + T A+K++ ++ + + + ++ E + HP ++ L Sbjct: 16 VIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGL 75 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 + T + F V+EYV+GG+L ++ + ++ E AR +I A++Y H +++RD Sbjct: 76 HSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRD 135 Query: 140 LKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 LK +NVLLD+ + K+ D+G+ + G+ T CG+PNY APE++ G Y G VD W Sbjct: 136 LKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY-GFSVDWW 194 Query: 199 SCGVILYALLCGTLPFD--------DEHVPT-LFKKIRGGVFYIPEYLNRSVATLLMHML 249 + GV+++ ++ G PFD D++ LF+ I IP L+ A++L L Sbjct: 195 ALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 254 Query: 250 QVDPLKR------ATIKDIREHEWFKQ 270 DP +R DI+ H +F+ Sbjct: 255 NKDPKERLGCHPQTGFADIQGHPFFRN 281 >4X7Q-B nrPDB Length = 312 Score = 125 bits (313), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 83/277 (29%), Positives = 141/277 (50%), Gaps = 20/277 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVG-KIKREIQNLKLFR- 72 Y LG LG G FG V G H+LT +VA+K++ R ++ + + ++ L++ Sbjct: 33 YRLGPLLGKGGFGTVFAG-HRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 73 -----HPHIIKLYQVISTPTDFFMVMEY-VSGGELFDYICKHGRVEEMEARRLFQQILSA 126 HP +I+L T F +V+E + +LFDYI + G + E +R F Q+++A Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAA 151 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + +CH VVHRD+K EN+L+D AK+ DFG ++ D + G+ Y+ PE I Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD-GTRVYSPPEWI 210 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 S Y +WS G++LY ++CG +PF+ + ++I + P +++ L+ Sbjct: 211 SRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCALI 264 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPS 282 L P R ++++I W + P+ P +PS Sbjct: 265 RRCLAPKPSSRPSLEEILLDPWMQT--PAEDVPLNPS 299 >2XNP-A nrPDB Length = 279 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 82/258 (31%), Positives = 132/258 (51%), Gaps = 15/258 (5%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 T+G G++G+ + + G + K L+ + + + E+ L+ +HP+I++ Y Sbjct: 13 TIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS-EVNLLRELKHPNIVRYY 71 Query: 81 QVI--STPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYCHR-- 132 I T T ++VMEY GG+L I K + ++E R+ Q+ A+ CHR Sbjct: 72 DRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRS 131 Query: 133 ---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGR 188 H V+HRDLKP NV LD N K+ DFGL+ +++ D F +T G+P Y +PE ++ R Sbjct: 132 DGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN-R 190 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF-YIPEYLNRSVATLLMH 247 + + DIWS G +LY L PF L KIR G F IP + + ++ Sbjct: 191 MSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITR 250 Query: 248 MLQVDPLKRATIKDIREH 265 ML + R ++++I E+ Sbjct: 251 MLNLKDYHRPSVEEILEN 268 >6E9W-A nrPDB Length = 443 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 142/278 (51%), Gaps = 16/278 (5%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI--RSLDVVGKIKRE 64 D R+K Y + +G G FG+V++ H+ T A+K+L++ ++ RS +R+ Sbjct: 95 RDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERD 154 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 I + P +++L+ +MVMEY+ GG+L + + + V E AR +++ Sbjct: 155 I--MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVV 211 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNYAAP 182 A+D H +HRD+KP+N+LLD + K+ADFG M+ +R T+ G+P+Y +P Sbjct: 212 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISP 271 Query: 183 EVI---SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI----RGGVFYIPE 235 EV+ G Y G E D WS GV LY +L G PF + + + KI F Sbjct: 272 EVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDN 331 Query: 236 YLNRSVATLLMHMLQVDPLK--RATIKDIREHEWFKQD 271 +++ L+ L ++ R +++I+ H +FK D Sbjct: 332 DISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKND 369 >5TUR-A nrPDB Length = 404 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 130/266 (48%), Gaps = 16/266 (6%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 74 ----PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAVD 128 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 247 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 248 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 306 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+ Sbjct: 307 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFFR-QRVSSECQHLIR 359 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 L + P R T ++I+ H W + L Sbjct: 360 WCLALRPSDRPTFEEIQNHPWMQDVL 385 >4L42-A nrPDB Length = 346 Score = 120 bits (302), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 83/262 (31%), Positives = 129/262 (49%), Gaps = 17/262 (6%) Query: 21 TLGVGTFGKV----KIGEHQLTGHKVAVKILNRQKI-RSLDVVGKIKREIQNLKLFRHPH 75 LG G +GKV K+ TG A+K+L + I R+ K E L+ +HP Sbjct: 25 VLGKGGYGKVFQVRKVTGAN-TGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPF 83 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L T ++++EY+SGGELF + + G E A +I A+ + H+ + Sbjct: 84 IVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGI 143 Query: 136 VHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVI--SGRLYAG 192 ++RDLKPEN++L+ + K+ DFGL + DG T CG+ Y APE++ SG A Sbjct: 144 IYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA- 202 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 VD WS G ++Y +L G PF E+ KI +P YL + LL +L+ + Sbjct: 203 --VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRN 260 Query: 253 PLKR-----ATIKDIREHEWFK 269 R +++ H +F+ Sbjct: 261 AASRLGAGPGDAGEVQAHPFFR 282 >6ED6-A nrPDB Length = 415 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 144/275 (52%), Gaps = 16/275 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI--RSLDVVGKIKREIQN 67 ++K Y + +G G FG+V++ H+ + A+K+L++ ++ RS +R+I Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI-- 141 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 + P +++L+ +MVMEY+ GG+L + + + V E A+ +++ A+ Sbjct: 142 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLAL 200 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNYAAPEVI 185 D H ++HRD+KP+N+LLD H + K+ADFG M + + T+ G+P+Y +PEV+ Sbjct: 201 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 260 Query: 186 ---SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFYIPE--YLN 238 G + G E D WS GV LY +L G PF + + + KI PE ++ Sbjct: 261 KSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEIS 320 Query: 239 RSVATLLMHMLQVDPLK--RATIKDIREHEWFKQD 271 + L+ L ++ R +++IR+H +FK D Sbjct: 321 KHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKND 355 >3BGP-A nrPDB Length = 333 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 130/266 (48%), Gaps = 16/266 (6%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 74 ----PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAVD 128 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 176 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 177 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 235 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+ Sbjct: 236 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFF-RQRVSSECQHLIR 288 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 L + P R T ++I+ H W + L Sbjct: 289 WCLALRPSDRPTFEEIQNHPWMQDVL 314 >4RC3-A nrPDB Length = 289 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 130/266 (48%), Gaps = 16/266 (6%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 74 ----PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAVD 128 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 132 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 133 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 191 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+ Sbjct: 192 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFF-RQRVSSECQHLIR 244 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 L + P R T ++I+ H W + L Sbjct: 245 WCLALRPSDRPTFEEIQNHPWMQDVL 270 >4RLP-A nrPDB Length = 288 Score = 119 bits (298), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 83/263 (31%), Positives = 129/263 (49%), Gaps = 17/263 (6%) Query: 21 TLGVGTFGKV----KIGEHQLTGHKVAVKILNRQKI-RSLDVVGKIKREIQNLKLFRHPH 75 LG G +GKV K+ TG A+K+L + I R+ K E L+ +HP Sbjct: 12 VLGKGGYGKVFQVRKVTGAN-TGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPF 70 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L T ++++EY+SGGELF + + G E A +I A+ + H+ + Sbjct: 71 IVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGI 130 Query: 136 VHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVI--SGRLYAG 192 ++RDLKPEN++L+ + K+ DFGL + DG T CG+ Y APE++ SG A Sbjct: 131 IYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA- 189 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 VD WS G ++Y +L G PF E+ KI +P YL + LL +L+ + Sbjct: 190 --VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRN 247 Query: 253 PLKR-----ATIKDIREHEWFKQ 270 R +++ H +F+ Sbjct: 248 AASRLGAGPGDAGEVQAHPFFRH 270 >1VZO-A nrPDB Length = 355 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 84/282 (29%), Positives = 143/282 (50%), Gaps = 19/282 (6%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKV----KIGEHQLTGHKVAVKILNRQKI-RSLDVVGKI 61 H +V I ++ L LG G +GKV KI H TG A+K+L + I + Sbjct: 47 HAEKVGIENFELLKVLGTGAYGKVFLVRKISGHD-TGKLYAMKVLKKATIVQKAKTTEHT 105 Query: 62 KREIQNLKLFRH-PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + E Q L+ R P ++ L+ T T ++++Y++GGELF ++ + R E E + Sbjct: 106 RTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYV 165 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPN 178 +I+ A+++ H+ +++RD+K EN+LLD++ + + DFGLS E R CG+ Sbjct: 166 GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIE 225 Query: 179 YAAPEVISGRLYAGPE-VDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYI 233 Y AP+++ G + VD WS GV++Y LL G PF + + ++I Sbjct: 226 YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY 285 Query: 234 PEYLNRSVATLLMHMLQVDPLKRA-----TIKDIREHEWFKQ 270 P+ ++ L+ +L DP KR +I+EH +F++ Sbjct: 286 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 327 >4EQM-A nrPDB Length = 294 Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 88/292 (30%), Positives = 142/292 (48%), Gaps = 21/292 (7%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVK---ILNRQKIRSLDVVGKIKREI 65 G++ Y + D LG G V + E + KVA+K I R+K +L + +RE+ Sbjct: 6 GKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETL---KRFEREV 62 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 N H +I+ + V +++VMEY+ G L +YI HG + A QIL Sbjct: 63 HNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPE 183 + + H +VHRD+KP+N+L+D++ KI DFG++ +S+ +T+ G+ Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 184 VISGRLYAGPE-VDIWSCGVILYALLCGTLPFDDE-HVPTLFKKIRGGVFYIPEYLNRSV 241 G A E DI+S G++LY +L G PF+ E V K I+ V + + + + Sbjct: 183 QAKGE--ATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDI 240 Query: 242 ATLLMHMLQVDPLKRATIKD----IREHEWFKQDLPSYLFPEDPSYDANVID 289 L +++ RAT KD + + K DL S L + D +D Sbjct: 241 PQSLSNVIL-----RATEKDKANRYKTIQEMKDDLSSVLHENRANEDVYELD 287 >6FD3-A nrPDB Length = 300 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 142/268 (52%), Gaps = 10/268 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y + +G G G V TG +VA+K +N Q+ ++ I EI ++ ++P+ Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNPN 80 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ + ++VMEY++GG L D + + ++E + + ++ L A+D+ H + V Sbjct: 81 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQV 139 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPE 194 +HRD+K +N+LL + K+ DFG ++ + R T G+P + APEV++ + Y GP+ Sbjct: 140 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPK 198 Query: 195 VDIWSCGVILYALLCGTLPFDDEH-VPTLFKKIRGGV--FYIPEYLNRSVATLLMHMLQV 251 VDIWS G++ ++ G P+ +E+ + L+ G PE L+ L L++ Sbjct: 199 VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM 258 Query: 252 DPLKRATIKDIREHEWFKQDLP-SYLFP 278 D +R + K++ +H + K D P S L P Sbjct: 259 DVDRRGSAKELLQHPFLKLDKPLSSLTP 286 >5CEK-A nrPDB Length = 263 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 70/209 (33%), Positives = 109/209 (52%), Gaps = 5/209 (2%) Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++L H +I + +VI T ++ E G++ Y+ R+ E EA RLF+QI+SAV Sbjct: 55 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAV 113 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEV 184 +CH+ +V DLK + ++ L + M + + L G P Y +PE+ Sbjct: 114 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 173 Query: 185 ISGR-LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 ++ Y+G D+WS GV+LY LL G PF D LF KIR G F IPE+++ Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 233 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDL 272 L+ +L+ +P +R T +I H WF+ L Sbjct: 234 LIRSLLRREPSERLTAPEILLHPWFESVL 262 >6DC0-A nrPDB Length = 292 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 70/209 (33%), Positives = 109/209 (52%), Gaps = 5/209 (2%) Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++L H +I + +VI T ++ E G++ Y+ R+ E EA RLF+QI+SAV Sbjct: 52 IQLPSHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAV 110 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEV 184 +CH+ +V DLK + ++ L + M + + L G P Y +PE+ Sbjct: 111 AHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 170 Query: 185 ISGR-LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 ++ Y+G D+WS GV+LY LL G PF D LF KIR G F IPE+++ Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARC 230 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDL 272 L+ +L+ +P +R T +I H WF+ L Sbjct: 231 LIRSLLRREPSERLTAPEILLHPWFESVL 259 >4KS7-A nrPDB Length = 292 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 86/281 (30%), Positives = 147/281 (52%), Gaps = 23/281 (8%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKI--LNRQKIRSLDVVGKIKREI 65 D R+ + YV +G G+ G V + + +G +VAVK+ L +Q+ R L + E+ Sbjct: 20 DPRLLLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL-----LFNEV 71 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 ++ ++H +++++Y+ + +++ME++ GG L D I R+ E + + + +L Sbjct: 72 VIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQ 130 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEV 184 A+ Y H V+HRD+K +++LL K++DFG +S R S G+P + APEV Sbjct: 131 ALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEV 190 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS---- 240 IS LYA EVDIWS G+++ ++ G P+ + K++R P L S Sbjct: 191 ISRSLYAT-EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSP---PPKLKNSHKVS 246 Query: 241 --VATLLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFP 278 + L ML DP +RAT +++ +H + Q LP L P Sbjct: 247 PVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVP 287 >3HKO-A nrPDB Length = 345 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 94/312 (30%), Positives = 142/312 (45%), Gaps = 60/312 (19%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--VGKIKREIQNLKLFRH 73 Y L +G G++G V++ T A+KI+N+ KIR ++ V +IK E++ +K H Sbjct: 28 YHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHH 87 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFD--------------------YICK------ 107 P+I +LY+V +VME GG L D IC Sbjct: 88 PNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNE 147 Query: 108 -------HGRVEEME-------ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--M 151 HG E ++ + +QI SA+ Y H + HRD+KPEN L + Sbjct: 148 EAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSF 207 Query: 152 NAKIADFGLSN---MMSDGEF--LRTSCGSPNYAAPEVISGRLYA-GPEVDIWSCGVILY 205 K+ DFGLS +++GE+ + T G+P + APEV++ + GP+ D WS GV+L+ Sbjct: 208 EIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLH 267 Query: 206 ALLCGTLPF-----DDEHVPTLFKKIRGGVFYIPEY--LNRSVATLLMHMLQVDPLKRAT 258 LL G +PF D L KK+ F P Y L+ LL ++L + +R Sbjct: 268 LLLMGAVPFPGVNDADTISQVLNKKL---CFENPNYNVLSPLARDLLSNLLNRNVDERFD 324 Query: 259 IKDIREHEWFKQ 270 +H W Q Sbjct: 325 AMRALQHPWISQ 336 >3PPZ-A nrPDB Length = 309 Score = 115 bits (289), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 80/257 (31%), Positives = 132/257 (51%), Gaps = 17/257 (6%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 + + +G G+FG V E G VAVKIL Q + + V + RE+ +K RHP+I+ Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHA-ERVNEFLREVAIMKRLRHPNIV 97 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR---LFQQILSAVDYCHRHM 134 ++ P + +V EY+S G L+ + K G E+++ RR + + ++Y H Sbjct: 98 LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRN 157 Query: 135 --VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL--RTSCGSPNYAAPEVISGRLY 190 +VHRDLK N+L+D K+ DFGLS + + FL +++ G+P + APEV+ Sbjct: 158 PPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKA-STFLSSKSAAGTPEWMAPEVLRDE-P 215 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVATLLMHM 248 + + D++S GVIL+ L P+ + + + + + IP LN VA ++ Sbjct: 216 SNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGC 275 Query: 249 LQVDPLKR---ATIKDI 262 +P KR ATI D+ Sbjct: 276 WTNEPWKRPSFATIMDL 292 >6CKI-A nrPDB Length = 316 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 94/309 (30%), Positives = 148/309 (47%), Gaps = 46/309 (14%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ--KIRSLDVVGKIKREIQ 66 GR + + + D LG G +V+ + +T + AVKI+ +Q IRS ++ RE++ Sbjct: 8 GRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRS-----RVFREVE 62 Query: 67 NL-KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 L + H ++++L + F++V E + GG + +I K E+EA + Q + S Sbjct: 63 MLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVAS 122 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMN----AKIADFGL-SNMMSDGEF-------LRTS 173 A+D+ H + HRDLKPEN+L + H N KI DFGL S + +G+ L T Sbjct: 123 ALDFLHNKGIAHRDLKPENILCE-HPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTP 181 Query: 174 CGSPNYAAPEVI-----SGRLYAGPEVDIWSCGVILYALLCGTLPF-----------DDE 217 CGS Y APEV+ +Y D+WS GVILY LL G PF E Sbjct: 182 CGSAEYMAPEVVEAFSEEASIY-DKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 240 Query: 218 HVPT----LFKKIRGGVFYIPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 P LF+ I+ G + P+ +++ + L+ +L D +R + + +H W + Sbjct: 241 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 Query: 270 QDLPSYLFP 278 P P Sbjct: 301 GCAPENTLP 309 >3Q53-A nrPDB Length = 306 Score = 114 bits (286), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 77/268 (28%), Positives = 142/268 (52%), Gaps = 10/268 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y + +G G G V TG +VA++ +N Q+ ++ I EI ++ ++P+ Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKEL---IINEILVMRENKNPN 79 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ + ++VMEY++GG L D + + ++E + + ++ L A+++ H + V Sbjct: 80 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQV 138 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPE 194 +HRD+K +N+LL + K+ DFG ++ + R T G+P + APEV++ + Y GP+ Sbjct: 139 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GPK 197 Query: 195 VDIWSCGVILYALLCGTLPFDDEH-VPTLFKKIRGGV--FYIPEYLNRSVATLLMHMLQV 251 VDIWS G++ ++ G P+ +E+ + L+ G PE L+ L L++ Sbjct: 198 VDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEM 257 Query: 252 DPLKRATIKDIREHEWFKQDLP-SYLFP 278 D KR + K++ +H++ K P S L P Sbjct: 258 DVEKRGSAKELIQHQFLKIAKPLSSLTP 285 >2F57-A nrPDB Length = 317 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 137/254 (53%), Gaps = 13/254 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKI--LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 +G G+ G V I + TG +VAVK L +Q+ R L + E+ ++ + H +++ + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRREL-----LFNEVVIMRDYHHDNVVDM 107 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + ++VME++ GG L D I H R+ E + + +L A+ Y H V+HRD Sbjct: 108 YSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGPEVDIW 198 +K +++LL + K++DFG +S R S G+P + APEVIS RL G EVDIW Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-RLPYGTEVDIW 225 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL---LMHMLQVDPLK 255 S G+++ ++ G P+ +E ++IR + + L++ + L L ML +P + Sbjct: 226 SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQ 285 Query: 256 RATIKDIREHEWFK 269 RAT +++ H + K Sbjct: 286 RATAQELLGHPFLK 299 >2HW6-A nrPDB Length = 307 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 83/300 (27%), Positives = 138/300 (46%), Gaps = 38/300 (12%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ + + + + LG G + KV+ G + AVKI+ +Q S ++ RE++ L Sbjct: 8 GKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRS---RVFREVETL 64 Query: 69 -KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 + + +I++L + T F++V E + GG + +I K E EA R+ + + +A+ Sbjct: 65 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL 124 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEF--------LRTSCGS 176 D+ H + HRDLKPEN+L ++ KI DF L + M L T CGS Sbjct: 125 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 184 Query: 177 PNYAAPEVIS----GRLYAGPEVDIWSCGVILYALLCGTLPF----------DDEHV--- 219 Y APEV+ + D+WS GV+LY +L G PF D V Sbjct: 185 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 244 Query: 220 --PTLFKKIRGGVFYIPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 273 LF+ I+ G + P+ +++ L+ +L D +R + + +H W + P Sbjct: 245 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP 304 >4FIE-A nrPDB Length = 423 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 140/264 (53%), Gaps = 14/264 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKI--LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 +G G+ G V I + +G VAVK L +Q+ R L + E+ ++ ++H +++++ Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-----LFNEVVIMRDYQHENVVEM 213 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + ++VME++ GG L D I H R+ E + + +L A+ H V+HRD Sbjct: 214 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGPEVDIW 198 +K +++LL K++DFG +S R S G+P + APE+IS RL GPEVDIW Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIW 331 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR---SVATLLMHMLQVDPLK 255 S G+++ ++ G P+ +E K IR + + L++ S+ L +L DP + Sbjct: 332 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 391 Query: 256 RATIKDIREHEWF-KQDLPSYLFP 278 RAT ++ +H + K P+ + P Sbjct: 392 RATAAELLKHPFLAKAGPPASIVP 415 >4XBR-A nrPDB Length = 366 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 140/264 (53%), Gaps = 14/264 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKI--LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 +G G+ G V I + +G VAVK L +Q+ R L + E+ ++ ++H +++++ Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-----LFNEVVIMRDYQHENVVEM 156 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + ++VME++ GG L D I H R+ E + + +L A+ H V+HRD Sbjct: 157 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGPEVDIW 198 +K +++LL K++DFG +S R S G+P + APE+IS RL GPEVDIW Sbjct: 216 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIW 274 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR---SVATLLMHMLQVDPLK 255 S G+++ ++ G P+ +E K IR + + L++ S+ L +L DP + Sbjct: 275 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 334 Query: 256 RATIKDIREHEWF-KQDLPSYLFP 278 RAT ++ +H + K P+ + P Sbjct: 335 RATAAELLKHPFLAKAGPPASIVP 358 >2Q0N-A nrPDB Length = 301 Score = 112 bits (280), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 82/264 (31%), Positives = 140/264 (53%), Gaps = 14/264 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKI--LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 +G G+ G V I + +G VAVK L +Q+ R L + E+ ++ ++H +++++ Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL-----LFNEVVIMRDYQHENVVEM 91 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + ++VME++ GG L D I H R+ E + + +L A+ H V+HRD Sbjct: 92 YNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGPEVDIW 198 +K +++LL K++DFG +S R S G+P + APE+IS RL GPEVDIW Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIW 209 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR---SVATLLMHMLQVDPLK 255 S G+++ ++ G P+ +E K IR + + L++ S+ L +L DP + Sbjct: 210 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 269 Query: 256 RATIKDIREHEWF-KQDLPSYLFP 278 RAT ++ +H + K P+ + P Sbjct: 270 RATAAELLKHPFLAKAGPPASIVP 293 >4JDH-A nrPDB Length = 346 Score = 112 bits (280), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 79/262 (30%), Positives = 141/262 (53%), Gaps = 10/262 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G+ G V I + +G VAVK ++ +K + ++ + E+ ++ ++H +++++Y Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL---LFNEVVIMRDYQHENVVEMYN 138 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 + ++VME++ GG L D I H R+ E + + +L A+ H V+HRD+K Sbjct: 139 SYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIK 197 Query: 142 PENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGPEVDIWSC 200 +++LL K++DFG +S R S G+P + APE+IS RL GPEVDIWS Sbjct: 198 SDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL 256 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR---SVATLLMHMLQVDPLKRA 257 G+++ ++ G P+ +E K IR + + L++ S+ L +L DP +RA Sbjct: 257 GIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRA 316 Query: 258 TIKDIREHEWF-KQDLPSYLFP 278 T ++ +H + K P+ + P Sbjct: 317 TAAELLKHPFLAKAGPPASIVP 338 >3ZDU-A nrPDB Length = 325 Score = 112 bits (280), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 82/285 (28%), Positives = 136/285 (47%), Gaps = 40/285 (14%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G++G V +H+ TG VA+KI + +S++ + REI+ LK F H +++ L + Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAM--REIKFLKQFHHENLVNLIE 68 Query: 82 VISTPTDFFMVMEYVSGGEL--FDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V +V E++ L + C HG +E R+ QIL A+DY H + ++HRD Sbjct: 69 VFRQKKKIHLVFEFIDHTVLDELQHYC-HG-LESKRLRKYLFQILRAIDYLHSNNIIHRD 126 Query: 140 LKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 +KPEN+L+ K+ DFG + + + G+ + Y APE++ G VDIW Sbjct: 127 IKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKPVDIW 186 Query: 199 SCGVILYALLCGT--LPFDDE----------------HVPTLFKK--IRGGVFYIPEY-- 236 + G ++ + G LP + H+ +F K I GV +P+ Sbjct: 187 ALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV-LPQVQH 245 Query: 237 ----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 LN +A ++ LQ+DP R + D+ HE+F +D Sbjct: 246 PKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 >4CRS-A nrPDB Length = 341 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 83/256 (32%), Positives = 131/256 (51%), Gaps = 15/256 (5%) Query: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI---KREIQNLKLFRHPHIIKLYQ 81 G FGKV + E++ T A+K L + I + D V + KR + + RHP ++ L+ Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFA 82 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ--ILSAVDYCHRHMVVHRD 139 T VMEY +GG+L +I H V E R +F ++ + Y H H +V+RD Sbjct: 83 CFQTKEHVCFVMEYAAGGDLMMHI--HTDVFS-EPRAVFYAACVVLGLQYLHEHKIVYRD 139 Query: 140 LKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 LK +N+LLD KIADFGL M G+ T CG+P + APEV++ Y VD W Sbjct: 140 LKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRA-VDWW 198 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR-- 256 GV++Y +L G PF + +F I P +L+ +++ +L+ +P +R Sbjct: 199 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 258 Query: 257 ---ATIKDIREHEWFK 269 +D+++H +F+ Sbjct: 259 ASEKDAEDVKKHPFFR 274 >4QMW-A nrPDB Length = 310 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 74/251 (29%), Positives = 126/251 (50%), Gaps = 6/251 (2%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G G+FG+V G T VA+KI++ ++ I++EI L P++ K Sbjct: 35 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED--IQQEITVLSQCDSPYVTKY 92 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y T +++MEY+ GG D + + G ++E + + ++IL +DY H +HRD Sbjct: 93 YGSYLKDTKLWIIMEYLGGGSALD-LLEPGPLDETQIATILREILKGLDYLHSEKKIHRD 151 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPEVDIW 198 +K NVLL H K+ADFG++ ++D + R T G+P + APEVI Y + DIW Sbjct: 152 IKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS-KADIW 210 Query: 199 SCGVILYALLCGTLPFDDEH-VPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRA 257 S G+ L G P + H + LF + + ++ + + L +P R Sbjct: 211 SLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRP 270 Query: 258 TIKDIREHEWF 268 T K++ +H++ Sbjct: 271 TAKELLKHKFI 281 >2BPM-A nrPDB Length = 309 Score = 110 bits (275), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 89/284 (31%), Positives = 130/284 (45%), Gaps = 38/284 (13%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G GT+G V ++LTG VA+K + R + V REI LK HP+I+KL Sbjct: 13 EKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKELNHPNIVKL 71 Query: 80 YQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 VI T ++V E++ + D G + LFQ +L + +CH H V+H Sbjct: 72 LDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ-LLQGLAFCHSHRVLH 130 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 194 RDLKP+N+L++ K+ADFGL+ G +RT + Y APE++ G Y Sbjct: 131 RDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTA 188 Query: 195 VDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG----------GVFYIPEY------- 236 VDIWS G I ++ F D + LF+ R GV +P+Y Sbjct: 189 VDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKW 248 Query: 237 -----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 L+ +LL ML DP KR + K H +F+ Sbjct: 249 ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 292 >4APC-A nrPDB Length = 350 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 70/268 (26%), Positives = 132/268 (49%), Gaps = 6/268 (2%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 YV +G G+FGK + + G + +K +N ++ S + + +RE+ L +HP+ Sbjct: 26 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKER-EESRREVAVLANMKHPN 84 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV--EEMEARRLFQQILSAVDYCHRH 133 I++ + ++VM+Y GG+LF I V +E + F QI A+ + H Sbjct: 85 IVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 144 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRD+K +N+ L ++ DFG++ ++ S E R G+P Y +PE+ + Y Sbjct: 145 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPYNN 204 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF-YIPEYLNRSVATLLMHMLQV 251 + DIW+ G +LY L F+ + L KI G F + + + + +L+ + + Sbjct: 205 -KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKR 263 Query: 252 DPLKRATIKDIREHEWFKQDLPSYLFPE 279 +P R ++ I E + + + +L P+ Sbjct: 264 NPRDRPSVNSILEKGFIAKRIEKFLSPQ 291 >2XIK-A nrPDB Length = 294 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 77/250 (30%), Positives = 124/250 (49%), Gaps = 6/250 (2%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 D +G G+FG+V G T VA+KI++ ++ I++EI L P+I + Sbjct: 25 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIED--IQQEITVLSQCDSPYITRY 82 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 + T +++MEY+ GG D + K G +EE + ++IL +DY H +HRD Sbjct: 83 FGSYLKSTKLWIIMEYLGGGSALD-LLKPGPLEETYIATILREILKGLDYLHSERKIHRD 141 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPEVDIW 198 +K NVLL + K+ADFG++ ++D + R T G+P + APEVI Y + DIW Sbjct: 142 IKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF-KADIW 200 Query: 199 SCGVILYALLCGTLPFDDEH-VPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRA 257 S G+ L G P D H + LF + + ++ + L DP R Sbjct: 201 SLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRP 260 Query: 258 TIKDIREHEW 267 T K++ +H++ Sbjct: 261 TAKELLKHKF 270 >4OTD-A nrPDB Length = 341 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 84/260 (32%), Positives = 131/260 (50%), Gaps = 15/260 (5%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI---KREIQNLKLFRHPHII 77 LG G FGKV + E + +G A+K L + I + D V + KR + + HP ++ Sbjct: 19 VLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLV 78 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ--ILSAVDYCHRHMV 135 L+ TP VMEY +GG+L +I H V E R +F ++ + + H H + Sbjct: 79 NLFGCFQTPEHVCFVMEYSAGGDLMLHI--HSDVFS-EPRAIFYSACVVLGLQFLHEHKI 135 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 V+RDLK +N+LLD KIADFGL M G+ T CG+P + APEV++ Y Sbjct: 136 VYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYT-RA 194 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPL 254 VD W GV+LY +L G PF + +F I P +L+ ++ +L+ +P Sbjct: 195 VDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPE 254 Query: 255 KRAT-----IKDIREHEWFK 269 +R +D+++ +F+ Sbjct: 255 RRLGSSERDAEDVKKQPFFR 274 >3M42-A nrPDB Length = 299 Score = 108 bits (270), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 93/313 (29%), Positives = 143/313 (45%), Gaps = 56/313 (17%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 75 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 21 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 72 Query: 76 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 129 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 130 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + HRD+KPEN+L + NA K+ DFG + + GE SC Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-ETTGEKYDKSC------------ 179 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE----YLN 238 D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 180 ---------DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 230 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ KE E Sbjct: 231 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL-----KEDKE 282 Query: 299 KFECTESEVMNSL 311 ++E + E+ ++L Sbjct: 283 RWEDVKEEMTSAL 295 >3COM-A nrPDB Length = 314 Score = 108 bits (269), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 76/255 (29%), Positives = 122/255 (47%), Gaps = 11/255 (4%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G++G V H+ TG VA+K ++ + +I +EI ++ PH++K Sbjct: 35 EKLGEGSYGSVYKAIHKETGQIVAIK-----QVPVESDLQEIIKEISIMQQCDSPHVVKY 89 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 Y TD ++VMEY G + D I ++ + E E + Q L ++Y H +HR Sbjct: 90 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHR 149 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPEVDI 197 D+K N+LL+ +AK+ADFG++ ++D R T G+P + APEVI Y DI Sbjct: 150 DIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY-NCVADI 208 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQVDPL 254 WS G+ + G P+ D H I F PE + + + L P Sbjct: 209 WSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPE 268 Query: 255 KRATIKDIREHEWFK 269 +RAT + +H + + Sbjct: 269 QRATATQLLQHPFVR 283 >4AW2-A nrPDB Length = 437 Score = 108 bits (269), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 110/213 (51%), Gaps = 7/213 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G FG+V + + + A+KILN+ ++ + E L I L+ Sbjct: 81 VIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLH 140 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 + ++VM+Y GG+L + K R+ E AR +++ A+D H+ VHRD Sbjct: 141 YAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRD 200 Query: 140 LKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRT-SCGSPNYAAPEVI----SGRLYAGP 193 +KP+N+L+D + + ++ADFG +M DG + + G+P+Y +PE++ G+ GP Sbjct: 201 IKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEGGKGRYGP 260 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 226 E D WS GV +Y +L G PF E + + KI Sbjct: 261 ECDWWSLGVCMYEMLYGETPFYAESLVETYGKI 293 >6BXI-A nrPDB Length = 333 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 114/242 (47%), Gaps = 37/242 (15%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G FG+V++ + + TGH A+KIL + + + VG I+ E L ++K++ Sbjct: 13 VIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMF 72 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + +++ME++ GG++ + K + E E + + + A+D H+ +HRD+ Sbjct: 73 YSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDI 132 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDG---EFLR-------------------------- 171 KP+N+LLD+ + K++DFGL + EF R Sbjct: 133 KPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKR 192 Query: 172 -------TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK 224 ++ G+P+Y APEV Y D WS GVI+Y +L G PF E +K Sbjct: 193 NRRQLAFSTVGTPDYIAPEVFMQTGY-NKLCDWWSLGVIMYEMLIGYPPFCSETPQETYK 251 Query: 225 KI 226 K+ Sbjct: 252 KV 253 >3TKU-A nrPDB Length = 433 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 110/213 (51%), Gaps = 7/213 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G FG+V + + + T A+KILN+ ++ + E L I L+ Sbjct: 97 VIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALH 156 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 ++VM+Y GG+L + K ++ E AR +++ A+D H+ VHRD Sbjct: 157 YAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRD 216 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPEVIS----GRLYAGP 193 +KP+NVLLD + + ++ADFG M+D +++S G+P+Y +PE++ G GP Sbjct: 217 IKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGP 276 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 226 E D WS GV +Y +L G PF E + + KI Sbjct: 277 ECDWWSLGVCMYEMLYGETPFYAESLVETYGKI 309 >5L2Q-C nrPDB Length = 320 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 57/165 (34%), Positives = 95/165 (57%), Gaps = 4/165 (2%) Query: 104 YICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLS- 161 Y+ K R+ E E +F ++ V+ H+ +VHRDLK N++L+ + I +F L Sbjct: 143 YVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGK 202 Query: 162 NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT 221 +++S+G+ L+ GSP Y +P+V+SGR Y G D+W+ GV+L+ +L G PF D Sbjct: 203 HLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQE 262 Query: 222 LFKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDIRE 264 LF+KI+ + IPE ++ + L+ +L +DP +R D+ E Sbjct: 263 LFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >1V0B-A nrPDB Length = 288 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 86/286 (30%), Positives = 137/286 (47%), Gaps = 40/286 (13%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G GT+G V ++ G A+K + +K + REI LK +H +I+KL Sbjct: 8 EKIGEGTYGVVYKAQNNY-GETFALKKIRLEK-EDEGIPSTTIREISILKELKHSNIVKL 65 Query: 80 YQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 Y VI T +V E++ +L D +C+ G +E + A+ Q+L+ + YCH V+H Sbjct: 66 YDVIHTKKRLVLVFEHLDQDLKKLLD-VCEGG-LESVTAKSFLLQLLNGIAYCHDRRVLH 123 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGPE 194 RDLKP+N+L++ KIADFGL+ G +R + Y AP+V+ G Sbjct: 124 RDLKPQNLLINREGELKIADFGLARAF--GIPVRKYTHEVVTLWYRAPDVLMGSKKYSTT 181 Query: 195 VDIWSCGVILYALLCGTLPF----DDEHVPTLFK-------KIRGGVFYIPEY------- 236 +DIWS G I ++ G F + + + +F+ K V +P+Y Sbjct: 182 IDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVY 241 Query: 237 -----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 L+ S LL ML++DP +R T K EH +FK++ Sbjct: 242 EPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >4AGU-A nrPDB Length = 311 Score = 105 bits (261), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 62/194 (31%), Positives = 102/194 (52%), Gaps = 8/194 (4%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIK-REIQNLKLFRHPHIIK 78 +G G++G V ++ TG VA+K + + S D V+ KI REI+ LK +HP+++ Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIK----KFLESEDDPVIKKIALREIRMLKQLKHPNLVN 66 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 L +V +V EY L + V E + + Q L AV++CH+H +HR Sbjct: 67 LLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHR 126 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSD-GEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 D+KPEN+L+ H K+ DFG + +++ ++ + Y +PE++ G GP VD+ Sbjct: 127 DVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPPVDV 186 Query: 198 WSCGVILYALLCGT 211 W+ G + LL G Sbjct: 187 WAIGCVFAELLSGV 200 >4FZF-B nrPDB Length = 283 Score = 104 bits (260), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 74/257 (28%), Positives = 123/257 (47%), Gaps = 20/257 (7%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G G+FG+V G T VA+KI++ ++ I++EI L ++ K Sbjct: 14 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIED--IQQEITVLSQCDSSYVTKY 71 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + +++MEY+ GG D + + G +E + + ++IL +DY H +HRD Sbjct: 72 YGSYLKGSKLWIIMEYLGGGSALD-LLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRD 130 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPEVDIW 198 +K NVLL + K+A FG++ ++D + R T G+P + APEVI Y + DIW Sbjct: 131 IKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY-DSKADIW 189 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY--------LNRSVATLLMHMLQ 250 S G+ L G P D H + +F IP+ +S + L Sbjct: 190 SLGITAIELAKGEPPNSDMHPMRV-------LFLIPKNNPPTLVGDFTKSFKEFIDACLN 242 Query: 251 VDPLKRATIKDIREHEW 267 DP R T K++ +H++ Sbjct: 243 KDPSFRPTAKELLKHKF 259 >5DBX-A nrPDB Length = 328 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 77/282 (27%), Positives = 135/282 (47%), Gaps = 32/282 (11%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-SLDVVGKIKREIQNLKLFRHP 74 Y L + +G G V+ + +VA+K +N +K + S+D ++ +EIQ + HP Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD---ELLKEIQAMSQCSHP 69 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--------KHGRVEEMEARRLFQQILSA 126 +++ Y + ++VM+ +SGG + D I K+G +EE + +++L Sbjct: 70 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 129 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG------EFLRTSCGSPNYA 180 +DY HR+ +HRDLK N+LL + +IADFG+S ++ G + + G+P + Sbjct: 130 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWM 189 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD------------DEHVPTLFKKIRG 228 APEV+ + D+WS G+ L G P+ PTL + Sbjct: 190 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVED 249 Query: 229 GVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + +Y +S LL LQ DP KR T ++ + ++F++ Sbjct: 250 KEM-MKKY-GKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >3DAK-A nrPDB Length = 290 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/282 (26%), Positives = 135/282 (47%), Gaps = 32/282 (11%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-SLDVVGKIKREIQNLKLFRHP 74 Y L + +G G V+ KVA+K +N +K + S+D ++ +EIQ + HP Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD---ELLKEIQAMSQCHHP 68 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--------KHGRVEEMEARRLFQQILSA 126 +I+ Y + ++VM+ +SGG + D I K G ++E + +++L Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 128 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG------EFLRTSCGSPNYA 180 ++Y H++ +HRD+K N+LL + +IADFG+S ++ G + +T G+P + Sbjct: 129 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 188 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD------------DEHVPTLFKKIRG 228 APEV+ + DIWS G+ L G P+ P+L ++ Sbjct: 189 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQD 248 Query: 229 GVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + +Y +S ++ LQ DP KR T ++ H++F++ Sbjct: 249 KEM-LKKY-GKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >3ORP-A nrPDB Length = 311 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 104/221 (47%), Gaps = 10/221 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y LG+ LG G +V + VAVK+L R + +RE QN HP Sbjct: 14 YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPA 73 Query: 76 IIKLYQVISTPTDF----FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 I+ +Y T ++VMEYV G L D + G + A + A+++ H Sbjct: 74 IVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSH 133 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD--GEFLRTSC--GSPNYAAPEVISG 187 ++ ++HRD+KP N+++ A K+ DFG++ ++D +T+ G+ Y +PE G Sbjct: 134 QNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARG 193 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIR 227 D++S G +LY +L G PF D V ++ +R Sbjct: 194 D-SVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVR 233 >3QA8-A nrPDB Length = 676 Score = 102 bits (253), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 70/213 (32%), Positives = 105/213 (49%), Gaps = 15/213 (7%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + + + LG G FG V HQ TG +VA+K RQ++ S + EIQ +K H Sbjct: 14 GPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC-RQEL-SPKNRERWCLEIQIMKKLNH 71 Query: 74 PHIIKLYQVIS-----TPTDF-FMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQIL 124 P+++ +V P D + MEY GG+L Y+ + ++E R L I Sbjct: 72 PNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDIS 131 Query: 125 SAVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 SA+ Y H + ++HRDLKPEN++L + KI D G + + GE G+ Y A Sbjct: 132 SALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLA 191 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 PE++ + Y VD WS G + + + G PF Sbjct: 192 PELLEQKKYT-VTVDYWSFGTLAFECITGFRPF 223 >4LG4-A nrPDB Length = 299 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 76/267 (28%), Positives = 127/267 (47%), Gaps = 27/267 (10%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G++G V H+ +G VA+K ++ + +I +EI ++ P+++K Sbjct: 17 EKLGEGSYGSVFKAIHKESGQVVAIK-----QVPVESDLQEIIKEISIMQQCDSPYVVKY 71 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 Y TD ++VMEY G + D I ++ + E E + + L ++Y H +HR Sbjct: 72 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHR 131 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPEVDI 197 ++K N+LL+ +AK+ADFG++ ++D R T G+P + APEVI Y DI Sbjct: 132 NIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY-NCVADI 190 Query: 198 WSCGVILYALLCGTLPFDDEH-------VPT----LFKKIRGGVFYIPEYLNRSVATLLM 246 WS G+ + G P+ D H +PT F+K PE + + Sbjct: 191 WSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK--------PELWSDDFTDFVK 242 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLP 273 L +P +RAT + +H + K P Sbjct: 243 KCLVKNPEQRATATQLLQHPFIKNAKP 269 >3NYO-A nrPDB Length = 576 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 128/261 (49%), Gaps = 12/261 (4%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 138 T +V+ ++GG+L +I G+ EAR +F +I ++ HR +V+R Sbjct: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 DLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W Sbjct: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWW 369 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP-EYLNR---SVATLLMHMLQVDPL 254 + G +LY ++ G PF +++ V +P EY R +L +L DP Sbjct: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPA 429 Query: 255 KR-----ATIKDIREHEWFKQ 270 +R + ++++EH FK+ Sbjct: 430 ERLGCRGGSAREVKEHPLFKK 450 >6AO5-A nrPDB Length = 362 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 74/259 (28%), Positives = 123/259 (47%), Gaps = 11/259 (4%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G++G V H+ +G VA+K ++ + +I +EI ++ P+++K Sbjct: 16 EKLGEGSYGSVFKAIHKESGQVVAIK-----QVPVESDLQEIIKEISIMQQCDSPYVVKY 70 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 Y TD ++VMEY G + D I ++ + E E + + L ++Y H +HR Sbjct: 71 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHR 130 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPEVDI 197 ++K N+LL+ +AK+ADFG++ ++D R T G+P + APEVI Y DI Sbjct: 131 NIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY-NCVADI 189 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQVDPL 254 WS G+ + G P+ D H I F PE + + L +P Sbjct: 190 WSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPE 249 Query: 255 KRATIKDIREHEWFKQDLP 273 +RAT + +H + K P Sbjct: 250 QRATATQLLQHPFIKNAKP 268 >6GU6-A nrPDB Length = 302 Score = 101 bits (251), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 71/218 (32%), Positives = 106/218 (48%), Gaps = 7/218 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y + +G GT+G V G H+ TG VA+K + R + V REI LK RHP+ Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 67 Query: 76 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 68 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 127 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEVISGRLYAG 192 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 128 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 187 Query: 193 PEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRG 228 VDIWS G I +A L P D + LF+ R Sbjct: 188 TPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRA 224 >2VD5-A nrPDB Length = 412 Score = 101 bits (251), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 104/215 (48%), Gaps = 9/215 (4%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G F +V + + + TG A+KI+N+ + V + E L I +L+ Sbjct: 68 VIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLH 127 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 ++VMEY GG+L + K G R+ AR +I+ A+D HR VHRD Sbjct: 128 FAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRD 187 Query: 140 LKPENVLLDAHMNAKIADFG-LSNMMSDGEFLR-TSCGSPNYAAPEVISG------RLYA 191 +KP+N+LLD + ++ADFG + +DG + G+P+Y +PE++ Sbjct: 188 IKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSY 247 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 226 GPE D W+ GV Y + G PF + + KI Sbjct: 248 GPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 282 >5G6V-A nrPDB Length = 324 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 79/290 (27%), Positives = 128/290 (44%), Gaps = 45/290 (15%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y+ D LG GT+ V G+ +LT + VA+K + + RE+ LK +H + Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI--REVSLLKDLKHAN 61 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHRHM 134 I+ L+ +I T +V EY+ +L Y+ G + M +LF Q+L + YCHR Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQK 120 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMS------DGEFLRTSCGSPNYAAPEVISGR 188 V+HRDLKP+N+L++ K+ADFGL+ S D E + + Y P+++ G Sbjct: 121 VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVV-----TLWYRPPDILLGS 175 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPF-------------------DDEHVPTLFKKIRGG 229 ++D+W G I Y + G F +E P + Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 235 Query: 230 VFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + P+Y L+ A LL +LQ + R + +D +H +F Sbjct: 236 TYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4KRC-A nrPDB Length = 317 Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 50/295 (16%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVA---VKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 + LG GT+ V G ++ TG VA VK+ + + S + REI +K +H +I Sbjct: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAI-----REISLMKELKHENI 65 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDY-----ICKHGRVEEMEARRLFQ-QILSAVDYC 130 ++LY VI T +V E++ +L Y + R E+ + FQ Q+L + +C Sbjct: 66 VRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 189 H + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ G Sbjct: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLF-------KKIRGGVFYIPEY-- 236 +DIWSCG IL ++ G F D+E + +F + + V +P+Y Sbjct: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Query: 237 ---------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 L+ ++ L +LQ++P R + K H WF + Sbjct: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >4TNB-A nrPDB Length = 590 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 62/196 (31%), Positives = 100/196 (51%), Gaps = 3/196 (1%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 191 VLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 138 T +V+ ++GG+L +I G E R LF +IL ++ H V+R Sbjct: 251 YAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYR 310 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 DLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Y G D W Sbjct: 311 DLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYW 369 Query: 199 SCGVILYALLCGTLPF 214 G ++Y ++ G PF Sbjct: 370 GLGCLIYEMIEGQSPF 385 >1TKI-A nrPDB Length = 321 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 123/264 (46%), Gaps = 12/264 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y++ + LG G FG V + K + K++ D V +K+EI L + RH + Sbjct: 7 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFV---KVKGTDQV-LVKKEISILNIARHRN 62 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHM 134 I+ L++ + + M+ E++SG ++F+ I + E E Q+ A+ + H H Sbjct: 63 ILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHN 122 Query: 135 VVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 + H D++PEN++ ++ KI +FG + + G+ R +P Y APEV + + Sbjct: 123 IGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVST 182 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM----HM 248 D+WS G ++Y LL G PF E + + I + E + ++ M + Sbjct: 183 A-TDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 241 Query: 249 LQVDPLKRATIKDIREHEWFKQDL 272 L + R T + +H W KQ + Sbjct: 242 LVKERKSRMTASEALQHPWLKQKI 265 >3SXS-A nrPDB Length = 268 Score = 99.0 bits (245), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 123/247 (49%), Gaps = 13/247 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG VK+G+ + + VAVK++ + + +E Q + HP ++K Y Sbjct: 16 LGSGQFGVVKLGKWK-GQYDVAVKMIKEGSMSEDEFF----QEAQTMMKLSHPKLVKFYG 70 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 V S ++V EY+S G L +Y+ HG+ +E + + + + + H +HRDL Sbjct: 71 VCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDL 130 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDI 197 N L+D + K++DFG++ + D +++ +S G+ ++APEV Y+ D+ Sbjct: 131 AARNCLVDRDLCVKVSDFGMTRYVLDDQYV-SSVGTKFPVKWSAPEVFHYFKYSSKS-DV 188 Query: 198 WSCGVILYALLC-GTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 W+ G++++ + G +P+D + + K +G Y P + ++ ++ P K Sbjct: 189 WAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEK 248 Query: 256 RATIKDI 262 R T + + Sbjct: 249 RPTFQQL 255 >5VO2-A nrPDB Length = 300 Score = 98.2 bits (243), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 72/247 (29%), Positives = 118/247 (47%), Gaps = 17/247 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G G V +G + G +VAVK K+R L + +I++L+ +HP+II Sbjct: 20 VGSGAQGAVFLG--RFHGEEVAVK-----KVRDLK-----ETDIKHLRKLKHPNIITFKG 67 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 V + + ++ME+ + G+L++ + + GR V I ++Y H H ++HRDL Sbjct: 68 VCTQAPCYCILMEFCAQGQLYE-VLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDL 126 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 K N+L+ KI+DFG S +SD + G+ + APEVI + +VDIWS Sbjct: 127 KSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVS-EKVDIWSF 185 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFY--IPEYLNRSVATLLMHMLQVDPLKRAT 258 GV+L+ LL G +P+ D + + + +P LL P R + Sbjct: 186 GVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPS 245 Query: 259 IKDIREH 265 + I H Sbjct: 246 FRQILLH 252 >4CSV-A nrPDB Length = 275 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 121/246 (49%), Gaps = 11/246 (4%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG+V G+ + +VAVK L + V + +E Q +K +HP++++LY Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQEAQIMKKLKHPNLVQLYG 74 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + +++ EY+S G L DY+ C+ V + Q+ S + Y +HRD Sbjct: 75 VCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHRD 134 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPEVISGRLYAGPEVDI 197 L N L+ + K+ADFGL+ ++++ E+ R P + APE IS ++ + D+ Sbjct: 135 LAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRFS-IKSDV 193 Query: 198 WSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 W+ G++L+ + G +P+ + +++ RG P+ + L++ P + Sbjct: 194 WAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQCWNKSPEE 253 Query: 256 RATIKD 261 R T + Sbjct: 254 RPTFAE 259 >4BBM-A nrPDB Length = 331 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 134/286 (46%), Gaps = 41/286 (14%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIK-REIQNLKLFRHPHIIK 78 +G G++G V ++ TG VA+K + + S D +V KI REI+ LK RH +++ Sbjct: 33 VGEGSYGMVMKCRNKDTGRIVAIK----KFLESDDDKMVKKIAMREIKLLKQLRHENLVN 88 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 L +V +++V E+V L D ++ ++ QI++ + +CH H ++HR Sbjct: 89 LLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHR 148 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSD-GEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 D+KPEN+L+ K+ DFG + ++ GE + Y APE++ G + G VD+ Sbjct: 149 DIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKAVDV 208 Query: 198 WSCGVILYALLCGT--LPFDDE-----HV-----------PTLFKK--IRGGVFYIPEY- 236 W+ G ++ + G P D + H+ LF K + GV +PE Sbjct: 209 WAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV-RLPEIK 267 Query: 237 -----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 L+ V L L +DP KR ++ H++F+ D Sbjct: 268 EREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMD 313 >5EFQ-A nrPDB Length = 347 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 82/320 (25%), Positives = 140/320 (43%), Gaps = 55/320 (17%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ + + + +G GT+G+V + TG VA+K + + + I REI+ L Sbjct: 6 GKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAI-REIKIL 64 Query: 69 KLFRHPHIIKLYQVISTPTD----------FFMVMEYVSGGELFDYICKHGRV--EEMEA 116 + H II + ++++ D F++V EY+ + + + G V E Sbjct: 65 RQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLM--GLLESGLVHFNENHI 122 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSC 174 + +Q++ +DYCH+ +HRD+K N+LL+ K+ADFGL+ + S E Sbjct: 123 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKV 182 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL---------------------LCGT-- 211 + Y PE++ G P +D+WSCG IL L +CG+ Sbjct: 183 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 242 Query: 212 ---------LPFDDEHVP--TLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 LP+ + P +K+R +IP + L +ML +DP KR T + Sbjct: 243 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPA----AALDLFDYMLALDPSKRCTAE 298 Query: 261 DIREHEWFKQDLPSYLFPED 280 + E+ + PS + P D Sbjct: 299 QALQCEFLRDVEPSKMPPPD 318 >2A1A-B nrPDB Length = 284 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 81/263 (30%), Positives = 127/263 (48%), Gaps = 38/263 (14%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G FG+V +H++ G +K R K + K +RE++ L H +I+ Y Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYVIK---RVKYNN----EKAEREVKALAKLDHVNIVH-YN 70 Query: 82 VISTPTDF-----------------FMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQ 122 D+ F+ ME+ G L +I K +++++ A LF+Q Sbjct: 71 GCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQ 130 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAA 181 I VDY H +++RDLKP N+ L KI DFGL +++ +DG+ R S G+ Y + Sbjct: 131 ITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTR-SKGTLRYMS 189 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALL--CGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR 239 PE IS + Y G EVD+++ G+IL LL C T F+ F +R G+ I + ++ Sbjct: 190 PEQISSQDY-GKEVDLYALGLILAELLHVCDT-AFE---TSKFFTDLRDGI--ISDIFDK 242 Query: 240 SVATLLMHMLQVDPLKRATIKDI 262 TLL +L P R +I Sbjct: 243 KEKTLLQKLLSKKPEDRPNTSEI 265 >4KIK-B nrPDB Length = 677 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 15/213 (7%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + + + LG G FG V +Q TG ++A+K RQ++ + + EIQ ++ H Sbjct: 19 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNR-ERWCLEIQIMRRLTH 76 Query: 74 PHIIKLYQVIS-----TPTDF-FMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQIL 124 P+++ V P D + MEY GG+L Y+ + + E L I Sbjct: 77 PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 136 Query: 125 SAVDYCHRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 SA+ Y H + ++HRDLKPEN++L + + KI D G + + G + G+ Y A Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLA 196 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 PE++ + Y VD WS G + + + G PF Sbjct: 197 PELLEQQKYT-VTVDYWSFGTLAFECITGFRPF 228 >3UIU-A nrPDB Length = 306 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 64/179 (35%), Positives = 96/179 (53%), Gaps = 13/179 (7%) Query: 89 FFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVL 146 F+ ME+ G L +I K +++++ A LF+QI VDY H ++HRDLKP N+ Sbjct: 109 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 168 Query: 147 LDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205 L KI DFGL +++ +DG+ R S G+ Y +PE IS + Y G EVD+++ G+IL Sbjct: 169 LVDTKQVKIGDFGLVTSLKNDGKRTR-SKGTLRYMSPEQISSQDY-GKEVDLYALGLILA 226 Query: 206 ALL--CGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 LL C T F+ F +R G+ I + ++ TLL +L P R +I Sbjct: 227 ELLHVCDT-AFE---TSKFFTDLRDGI--ISDIFDKKEKTLLQKLLSKKPEDRPNTSEI 279 >2DQ7-X nrPDB Length = 283 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 77/270 (28%), Positives = 131/270 (48%), Gaps = 23/270 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG+V +G KVA+K L + + E Q +K +H +++LY Sbjct: 17 LGNGQFGEVWMGTWN-GNTKVAIKTLKPGTMSPESFL----EEAQIMKKLKHDKLVQLYA 71 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ---QILSAVDYCHRHMVVHR 138 V+S ++V EY++ G L D++ K G ++ L Q+ + + Y R +HR Sbjct: 72 VVSE-EPIYIVTEYMNKGSLLDFL-KDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR 129 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAGPEV 195 DL+ N+L+ + KIADFGL+ ++ D E+ R P + APE + GR + Sbjct: 130 DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI--KS 187 Query: 196 DIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVDP 253 D+WS G++L L+ G +P+ + + +++ RG P+ S+ L++H + DP Sbjct: 188 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 247 Query: 254 LKRATIKDIREHEWFKQDLPSYLFPEDPSY 283 +R T E+ + L Y +P Y Sbjct: 248 EERPTF------EYLQSFLEDYFTATEPQY 271 >3A4O-X nrPDB Length = 286 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 102/198 (51%), Gaps = 11/198 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG+V +G + KVAVK L + V E +K +H +++LY Sbjct: 21 LGAGQFGEVWMGYYN-NSTKVAVKTLKPGTMS----VQAFLEEANLMKTLQHDKLVRLYA 75 Query: 82 VISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V++ +++ EY++ G L D++ + G+V + QI + Y R +HRD Sbjct: 76 VVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD 135 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPEVISGRLYAGPEVDI 197 L+ NVL+ + KIADFGL+ ++ D E+ R P + APE I+ + + D+ Sbjct: 136 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT-IKSDV 194 Query: 198 WSCGVILYALLC-GTLPF 214 WS G++LY ++ G +P+ Sbjct: 195 WSFGILLYEIVTYGKIPY 212 >2H8H-A nrPDB Length = 535 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 129/273 (47%), Gaps = 29/273 (10%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 275 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 329 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------QILSAVDYCHRHMV 135 V+S ++V EY+S G L D++ + E + RL Q QI S + Y R Sbjct: 330 VVSE-EPIYIVTEYMSKGSLLDFL----KGETGKYLRLPQLVDMAAQIASGMAYVERMNY 384 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAG 192 VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR Sbjct: 385 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI- 443 Query: 193 PEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQ 250 + D+WS G++L L G +P+ + ++ RG P S+ L+ + Sbjct: 444 -KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 502 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 283 +P +R T E+ + L Y +P Y Sbjct: 503 KEPEERPTF------EYLQAFLEDYFTSTEPQY 529 >5D7A-A nrPDB Length = 308 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/225 (31%), Positives = 108/225 (48%), Gaps = 30/225 (13%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVG----KIKREIQNLK 69 G + L + +G GT+G+V G H TG A+K++ DV G +IK+EI LK Sbjct: 17 GIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVM--------DVTGDEEEEIKQEINMLK 68 Query: 70 LFRHPHIIKLYQ---VISTP----TDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLF 120 + H I Y + P ++VME+ G + D I K ++E + Sbjct: 69 KYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYIC 128 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNY 179 ++IL + + H+H V+HRD+K +NVLL + K+ DFG+S + R T G+P + Sbjct: 129 REILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 188 Query: 180 AAPEVISGRLYAGPEV------DIWSCGVILYALLCGTLPFDDEH 218 APEVI+ P+ D+WS G+ + G P D H Sbjct: 189 MAPEVIA--CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMH 231 >5X5O-A nrPDB Length = 310 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 81/262 (30%), Positives = 119/262 (45%), Gaps = 24/262 (9%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 ++K + G G+FG V + +VAVK L KI++E + L Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL-----------KIEKEAEILS 59 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF---QQILSA 126 + H +II+ Y VI P ++ +V EY S G L+DYI R EEM+ + + Sbjct: 60 VLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYI-NSNRSEEMDMDHIMTWATDVAKG 118 Query: 127 VDYCHRHM---VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 + Y H V+HRDLK NV++ A KI DFG S + + + G+ + APE Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPE 177 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIPEYLNRS 240 VI L D +S GV+L+ +L +PF + V L + + IP RS Sbjct: 178 VIQS-LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE-KNERLTIPSSCPRS 235 Query: 241 VATLLMHMLQVDPLKRATIKDI 262 A LL + D KR + K I Sbjct: 236 FAELLHQCWEADAKKRPSFKQI 257 >6CQF-A nrPDB Length = 297 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/265 (27%), Positives = 121/265 (45%), Gaps = 13/265 (4%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 HY L LG GT+G+V +++G VA+K++ K+ D V +++EI LK RH Sbjct: 17 HYDLLQRLGGGTYGEVFKARDKVSGDLVALKMV---KMEPDDDVSTLQKEILILKTCRHA 73 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I+ + ++ ME+ G L D G + E++ + +++L + Y H Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQK 133 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGP 193 +HRD+K N+L++ ++ADFG+S + R + G+P + APEV + L G Sbjct: 134 KIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGY 193 Query: 194 E--VDIWSCGVILYALLCGTLPFDDEH-VPTLFKKIRGGVFYIPEYLNRSVATLLMH--- 247 DIWS G+ L P D H + LF + G + P + + H Sbjct: 194 NELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG-YQPPRLKEKGKWSAAFHNFI 252 Query: 248 --MLQVDPLKRATIKDIREHEWFKQ 270 L P KR + + H+ Q Sbjct: 253 KVTLTKSPKKRPSATKMLSHQLVSQ 277 >1ZXE-A nrPDB Length = 303 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/284 (25%), Positives = 127/284 (44%), Gaps = 45/284 (15%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-SLDVVGKIKREIQNLKLFRHPHIIKL 79 LG G FG+V + L A+K KIR + + + I E+ L H ++++ Sbjct: 13 VLGQGAFGQVVKARNALDSRYYAIK-----KIRHTEEKLSTILSEVMLLASLNHQYVVRY 67 Query: 80 Y-------------QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM-EARRLFQQILS 125 Y + + F+ MEY L+D I ++ E RLF+QIL Sbjct: 68 YAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILE 127 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---------------NMMSDGEFL 170 A+ Y H ++HR+LKP N+ +D N KI DFGL+ N+ + L Sbjct: 128 ALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNL 187 Query: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDD--EHVPTLFKKIRG 228 ++ G+ Y A EV+ G + ++D++S G+I + ++ PF E V + KK+R Sbjct: 188 TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERV-NILKKLRS 243 Query: 229 -GVFYIPEYLNRSVAT---LLMHMLQVDPLKRATIKDIREHEWF 268 + + P++ + + ++ ++ DP KR + + W Sbjct: 244 VSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >2W96-B nrPDB Length = 306 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 88/290 (30%), Positives = 135/290 (46%), Gaps = 46/290 (15%) Query: 22 LGVGTFGKVKIGEHQLTGHKVA---VKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 +GVG +G V +GH VA V++ N ++ + V ++ ++ L+ F HP++++ Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVAL-LRRLEAFEHPNVVR 70 Query: 79 LYQVISTP-TD----FFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQILSAVDYC 130 L V +T TD +V E+V +L Y+ K G E + L +Q L +D+ Sbjct: 71 LMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAET-IKDLMRQFLRGLDFL 128 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV+ Y Sbjct: 129 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQSTY 188 Query: 191 AGPEVDIWSCGVILY------ALLCGT--------------LPFDDEHVPTLFKKIRGGV 230 A P VD+WS G I L CG LP +D+ P RG Sbjct: 189 ATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-PRDVSLPRGAF 246 Query: 231 ---------FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 +PE + S A LL+ ML +P KR + +H + +D Sbjct: 247 PPRGPRPVQSVVPE-MEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 295 >5O0Y-A nrPDB Length = 579 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 64/169 (37%), Positives = 86/169 (50%), Gaps = 17/169 (10%) Query: 63 REIQNLKLFRHPHIIKLYQVISTPTD-FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE + K HP I+KLY S TD F V+EY G +L Y+ +H + E EAR + Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIM 396 Query: 122 QILSAVDYCH--RHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDG--------E 168 QI++A+ Y + + ++H DLKP N+LL A KI DFGLS +M D E Sbjct: 397 QIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGME 456 Query: 169 FLRTSCGSPNYAAPEV-ISGRL--YAGPEVDIWSCGVILYALLCGTLPF 214 G+ Y PE + G+ +VD+WS GVI Y L G PF Sbjct: 457 LTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 505 >5UUU-A nrPDB Length = 547 Score = 92.8 bits (229), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 133/290 (45%), Gaps = 27/290 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH---PHIIK 78 +G G FG+V TG A+K L++++I+ E L L P I+ Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 + TP +++ ++GG+L ++ +HG E + R +I+ +++ H VV+R Sbjct: 266 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 325 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 326 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 384 Query: 199 SCGVILYALLCGTLPF-----DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 253 S G +L+ LL G PF D+H + + +P+ + + +LL +LQ D Sbjct: 385 SLGCMLFKLLRGHSPFRQHKTKDKH--EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 442 Query: 254 LKRATI-----KDIREHEWFK---------QDLPSYLFPEDPSYDANVID 289 +R ++++E +F+ Q P L P P + N D Sbjct: 443 NRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 490 >1CM8-A nrPDB Length = 367 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 68/200 (34%), Positives = 100/200 (50%), Gaps = 13/200 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V TG KVA+K L R +S + RE++ LK RH ++I L Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 Query: 82 VISTP-------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 V TP TDF++VM ++ G + KH ++ E + L Q+L + Y H Sbjct: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 Query: 195 VDIWSCGVILYALLCGTLPF 214 VDIWS G I+ ++ G F Sbjct: 207 VDIWSVGCIMAEMITGKTLF 226 >3PVW-A nrPDB Length = 695 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 133/290 (45%), Gaps = 27/290 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH---PHIIK 78 +G G FG+V TG A+K L++++I+ E L L P I+ Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 + TP +++ ++GG+L ++ +HG E + R +I+ +++ H VV+R Sbjct: 257 MSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 DLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ + D + Sbjct: 317 DLKPANILLDEHGHVRISDLGLACDFSKKK-PHASVGTHGYMAPEVLQKGVAYDSSADWF 375 Query: 199 SCGVILYALLCGTLPF-----DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 253 S G +L+ LL G PF D+H + + +P+ + + +LL +LQ D Sbjct: 376 SLGCMLFKLLRGHSPFRQHKTKDKH--EIDRMTLTMAVELPDSFSPELRSLLEGLLQRDV 433 Query: 254 LKRATI-----KDIREHEWFK---------QDLPSYLFPEDPSYDANVID 289 +R ++++E +F+ Q P L P P + N D Sbjct: 434 NRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 481 >6DTL-A nrPDB Length = 364 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 79/315 (25%), Positives = 134/315 (42%), Gaps = 42/315 (13%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA-KRTLREIKLLRHMDHENIVAIRD 96 Query: 82 VISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 +I P D ++ E + +L I + + E + QIL + Y H V+ Sbjct: 97 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 155 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 156 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 215 Query: 197 IWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGG----------------VFYIPEYL 237 +WS G I L+ F D H L ++ G + +P Y Sbjct: 216 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 275 Query: 238 NRSVA-----------TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDP 281 +S+ L+ ML DP +R T+ D H + D P P + Sbjct: 276 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNF 335 Query: 282 SYDANVIDDEAVKEV 296 ++ + + +E +KE+ Sbjct: 336 DFENHALSEEQMKEL 350 >3NIZ-A nrPDB Length = 311 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 85/287 (29%), Positives = 134/287 (46%), Gaps = 45/287 (15%) Query: 20 DTLGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 + +G GT+G V K + Q G VA+K + R + REI LK HP+I+ Sbjct: 27 EKVGEGTYGVVYKAKDSQ--GRIVALKRI-RLDAEDEGIPSTAIREISLLKELHHPNIVS 83 Query: 79 LYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 L VI + +V E++ ++ D K G +++ + + Q+L V +CH+H ++ Sbjct: 84 LIDVIHSERCLTLVFEFMEKDLKKVLDE-NKTG-LQDSQIKIYLYQLLRGVAHCHQHRIL 141 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGP 193 HRDLKP+N+L+++ K+ADFGL+ G +R+ + Y AP+V+ G Sbjct: 142 HRDLKPQNLLINSDGALKLADFGLARAF--GIPVRSYTHEVVTLWYRAPDVLMGSKKYST 199 Query: 194 EVDIWSCGVILYALLCGTLPF----DDEHVPTLF--------------------KKIRGG 229 VDIWS G I ++ G F DD+ +P +F K+ Sbjct: 200 SVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTFQ 259 Query: 230 VF-------YIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 VF IP + + LL +ML DP KR + +D H +FK Sbjct: 260 VFEKKPWSSIIPGFCQEGI-DLLSNMLCFDPNKRISARDAMNHPYFK 305 >4U41-A nrPDB Length = 332 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 108/221 (48%), Gaps = 22/221 (9%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + L + +G GT+G+V G H TG A+K+++ + D +IK EI LK + H Sbjct: 24 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKLEINMLKKYSH 79 Query: 74 PHIIKLYQ---VISTP----TDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQIL 124 I Y + +P ++VME+ G + D + K ++E + ++IL Sbjct: 80 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREIL 139 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPE 183 + + H H V+HRD+K +NVLL + K+ DFG+S + R T G+P + APE Sbjct: 140 RGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 199 Query: 184 VISGRLYAGPEV------DIWSCGVILYALLCGTLPFDDEH 218 VI+ P+ D+WSCG+ + G P D H Sbjct: 200 VIA--CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH 238 >3GC0-A nrPDB Length = 329 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 132/288 (45%), Gaps = 42/288 (14%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG GT+G+V +T VA+K + R + V G RE+ LK +H +II+L Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIKRI-RLEHEEEGVPGTAIREVSLLKELQHRNIIELKS 100 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 VI ++ EY +L Y+ K+ V + Q+++ V++CH +HRDLK Sbjct: 101 VIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRDLK 159 Query: 142 PENVLL---DAHMNA--KIADFGLSNMMSDGEFLRT---SCGSPNYAAPEVISGRLYAGP 193 P+N+LL DA KI DFGL+ G +R + Y PE++ G + Sbjct: 160 PQNLLLSVSDASETPVLKIGDFGLARAF--GIPIRQFTHEIITLWYRPPEILLGSRHYST 217 Query: 194 EVDIWSCGVILYALLCGTLPF-DDEHVPTLFK--KIRG--------GVFYIPEY------ 236 VDIWS I +L T F D + LFK ++ G GV +P++ Sbjct: 218 SVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPDWKQSFPK 277 Query: 237 -----LNRSVATLLMH--------MLQVDPLKRATIKDIREHEWFKQD 271 L R + LL ML++DP+KR + K+ EH +F + Sbjct: 278 FRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHN 325 >4NST-A nrPDB Length = 351 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/320 (24%), Positives = 141/320 (44%), Gaps = 55/320 (17%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ + + + +G GT+G+V + + TG VA+K + + + I REI+ L Sbjct: 8 GKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAI-REIKIL 66 Query: 69 KLFRHPHIIKLYQVISTPTD----------FFMVMEYVSGGELFDYICKHGRV--EEMEA 116 + H ++ + ++++ D F++V EY+ + + + G V E Sbjct: 67 RQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLM--GLLESGLVHFSEDHI 124 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSC 174 + +Q++ ++YCH+ +HRD+K N+LL+ K+ADFGL+ + + E Sbjct: 125 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 184 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL---------------------LCGT-- 211 + Y PE++ G P +D+WSCG IL L LCG+ Sbjct: 185 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 244 Query: 212 ---------LPFDDEHVP--TLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 LP+ + P +++R +IP + LL HML +DP KR T + Sbjct: 245 PAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPS----AALDLLDHMLTLDPSKRCTAE 300 Query: 261 DIREHEWFKQDLPSYLFPED 280 + ++ K S + P D Sbjct: 301 QTLQSDFLKDVELSKMAPPD 320 >5SYS-A nrPDB Length = 286 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/272 (28%), Positives = 129/272 (47%), Gaps = 25/272 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG+ +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 26 LGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 80 Query: 82 VISTPTDFFMVMEYVSGGELFDYI----CKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 V+S ++V EY+S G L D++ K+ R+ ++ + QI S + Y R VH Sbjct: 81 VVSE-EPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQL--VDMAAQIASGMAYVERMNYVH 137 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAGPE 194 RDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR + Sbjct: 138 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI--K 195 Query: 195 VDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVD 252 D+WS G++L L G +P+ + ++ RG P S+ L+ + D Sbjct: 196 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKD 255 Query: 253 PLKRATIKDIREHEWFKQDLPSYLFPEDPSYD 284 P +R T E+ + L Y +P Y Sbjct: 256 PEERPTF------EYLQAFLEDYFTSTEPQYQ 281 >4X3F-A nrPDB Length = 337 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 99/219 (45%), Gaps = 8/219 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G Y L + G G+V G +VAVK+L + + + + + E + + H Sbjct: 12 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 71 Query: 74 PHIIKLY-----QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 P I ++ Q+ ++VME V+G L + + GR+ A + +Q A+ Sbjct: 72 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 131 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPEVIS 186 H +VHRD+KP N+L+ KI DFG++ + +T G+ Y APE Sbjct: 132 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 191 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 G A P D++S GV+ Y + G PF + T+ K Sbjct: 192 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK 229 >4E93-A nrPDB Length = 377 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 69/256 (26%), Positives = 119/256 (46%), Gaps = 17/256 (6%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 VLG+ +G G FG+V G + VAVK + ++ D+ K +E + LK + HP+I Sbjct: 117 VLGEQIGRGNFGEVFSGRLRADNTLVAVK--SCRETLPPDLKAKFLQEARILKQYSHPNI 174 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI---LSAVDYCHRH 133 ++L V + ++VME V GG+ ++ G + + L Q + + ++Y Sbjct: 175 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG--ARLRVKTLLQMVGDAAAGMEYLESK 232 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLY 190 +HRDL N L+ KI+DFG+S +DG + + + APE ++ Y Sbjct: 233 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 292 Query: 191 AGPEVDIWSCGVILYALLC-GTLPF---DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 + E D+WS G++L+ G P+ ++ +K GG PE +V L+ Sbjct: 293 SS-ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEK--GGRLPCPELCPDAVFRLME 349 Query: 247 HMLQVDPLKRATIKDI 262 +P +R + I Sbjct: 350 QCWAYEPGQRPSFSTI 365 >4OW8-A nrPDB Length = 283 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 99/219 (45%), Gaps = 8/219 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G Y L + G G+V G +VAVK+L + + + + + E + + H Sbjct: 11 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 70 Query: 74 PHIIKLY-----QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 P I ++ Q+ ++VME V+G L + + GR+ A + +Q A+ Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 130 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPEVIS 186 H +VHRD+KP N+L+ KI DFG++ + +T G+ Y APE Sbjct: 131 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 190 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 G A P D++S GV+ Y + G PF + T+ K Sbjct: 191 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK 228 >3OHT-A nrPDB Length = 389 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 88/324 (27%), Positives = 145/324 (44%), Gaps = 48/324 (14%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V +G K+AVK L+R +S+ + RE++ LK +H ++I L Sbjct: 59 VGSGAYGSVCSSYDVKSGLKIAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 117 Query: 82 VISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 V + T D ++V ++ G +L + I K ++ + + L QIL + Y H + Sbjct: 118 VFTPATSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSADI 175 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 +HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ V Sbjct: 176 IHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNMTV 233 Query: 196 DIWSCGVILYALLCG-TLPFDDEHVPTLFK-------------------KIRGGVFYIPE 235 DIWS G I+ LL G TL +H+ L + + R + +P+ Sbjct: 234 DIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQ 293 Query: 236 YLNRSVA-----------TLLMHMLQVDPLKRATIKDIREHEWFKQ-----DLPSYLFPE 279 R+ A LL ML +D KR T + H +F Q D P P Sbjct: 294 MPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDPDDEPESE-PY 352 Query: 280 DPSYDANVIDDEAVKEVCEKFECT 303 D S+++ ++ E K + + C+ Sbjct: 353 DQSFESRQLEIEEWKRLTYEEVCS 376 >6F3F-A nrPDB Length = 455 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 79/273 (28%), Positives = 129/273 (47%), Gaps = 29/273 (10%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 195 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 249 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------QILSAVDYCHRHMV 135 V+S ++V EY++ G L D++ + E + RL Q QI S + Y R Sbjct: 250 VVSE-EPIYIVTEYMNKGSLLDFL----KGETGKYLRLPQLVDMSAQIASGMAYVERMNY 304 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAG 192 VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR Sbjct: 305 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI- 363 Query: 193 PEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQ 250 + D+WS G++L L G +P+ + ++ RG P S+ L+ + Sbjct: 364 -KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 422 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 283 +P +R T E+ + L Y +P Y Sbjct: 423 KEPEERPTF------EYLQAFLEDYFTSTEPQY 449 >2XYN-A nrPDB Length = 292 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 57/191 (29%), Positives = 99/191 (51%), Gaps = 11/191 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V +G + VAVK L + V + +E +K +HP++++L Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVMKEIKHPNLVQLLG 95 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F++V EY+ G L DY+ C V + + QI SA++Y + +HRD Sbjct: 96 VCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRD 155 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L+ + K+ADFGLS +M+ G+ G+ + APE ++ ++ + D Sbjct: 156 LAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNTFS-IKSD 213 Query: 197 IWSCGVILYAL 207 +W+ GV+L+ + Sbjct: 214 VWAFGVLLWEI 224 >6E2O-A nrPDB Length = 295 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 78/261 (29%), Positives = 120/261 (45%), Gaps = 18/261 (6%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG GT+G V G ++A+K + + R + EI K +H +I++ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ---PLHEEIALHKHLKHKNIVQYL 85 Query: 81 QVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLF--QQILSAVDYCHRHMVVH 137 S + ME V GG L + K G +++ E F +QIL + Y H + +VH Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 138 RDLKPENVLLDAHMNA-KIADFGLSNMMSD-GEFLRTSCGSPNYAAPEVI-SGRLYAGPE 194 RD+K +NVL++ + KI+DFG S ++ T G+ Y APE+I G G Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKA 205 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVP--TLFKKIRGGVFY----IPEYLNRSVATLLMHM 248 DIWS G + + G PF + P +FK G+F IPE ++ ++ Sbjct: 206 ADIWSLGCTIIEMATGKPPFYELGEPQAAMFKV---GMFKVHPEIPESMSAEAKAFILKC 262 Query: 249 LQVDPLKRATIKDIREHEWFK 269 + DP KRA D+ E+ K Sbjct: 263 FEPDPDKRACANDLLVDEFLK 283 >4EBW-A nrPDB Length = 304 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 71/252 (28%), Positives = 118/252 (46%), Gaps = 8/252 (3%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 LG +G G FG V G + + +AV I + S V K +E ++ F HPHI Sbjct: 42 LGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHI 101 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHRHMV 135 +KL VI T +++ME + GEL ++ ++ + L+ Q+ +A+ Y Sbjct: 102 VKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRF 160 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS--PNYAAPEVISGRLYAGP 193 VHRD+ NVL+ ++ K+ DFGLS M D + + S G + APE I+ R + Sbjct: 161 VHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSA 220 Query: 194 EVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQV 251 D+W GV ++ +L G PF + +I G +P ++ +L+ Sbjct: 221 S-DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAY 279 Query: 252 DPLKRATIKDIR 263 DP +R +++ Sbjct: 280 DPSRRPRFTELK 291 >5H2U-A nrPDB Length = 267 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 124/255 (48%), Gaps = 12/255 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + L LG G FG+V G + +VA+K+++R + + ++ EIQ +K RH H Sbjct: 8 FTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQM---LQSEIQAMKKLRHKH 63 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRH 133 I+ LY V+S +++ E ++ G L + + + E + Q+ + Y Sbjct: 64 ILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQ 123 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP-NYAAPEVISGRLYAG 192 +HRDL N+L+ + K+ DFGL+ ++ + +L P + APE +S R + Sbjct: 124 NYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS-RGHYS 182 Query: 193 PEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLN--RSVATLLMHML 249 + D+WS G++L+ + G +P+ F ++ G + +P L SV L++ Sbjct: 183 TKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAG-YRMPCPLECPPSVHKLMLTCW 241 Query: 250 QVDPLKRATIKDIRE 264 DP +R T K +RE Sbjct: 242 CRDPEQRPTFKALRE 256 >6B2Q-A nrPDB Length = 317 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 99/219 (45%), Gaps = 8/219 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G Y L + G G+V G +VAVK+L + + + + + E + + H Sbjct: 32 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 91 Query: 74 PHIIKLY-----QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 P I ++ Q+ ++VME V+G L + + GR+ A + +Q A+ Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQ 151 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPEVIS 186 H +VHRD+KP N+L+ KI DFG++ + +T G+ Y APE Sbjct: 152 IAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQAL 211 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 G A P D++S GV+ Y + G PF + T+ K Sbjct: 212 GH-DASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK 249 >5HI2-A nrPDB Length = 283 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/219 (30%), Positives = 111/219 (50%), Gaps = 24/219 (10%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D + G +G +G G+FG V G+ VAVK+L Q++++ K E+ Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKGKWH---GDVAVKMLTPQQLQAF------KNEVGV 64 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF---QQIL 124 L+ RH +I+ L+ ST +V ++ G L+ ++ H + E ++L +Q Sbjct: 65 LRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHL--HASETKFEMKKLIDIARQTA 121 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS----DGEFLRTSCGSPNYA 180 +DY H ++HRDLK N+ L KI DFGL+ + S +F + S GS + Sbjct: 122 RGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLS-GSILWM 180 Query: 181 APEVISGRLYAGP---EVDIWSCGVILYALLCGTLPFDD 216 APEVI + + P + D+++ G++LY L+ G LP+ + Sbjct: 181 APEVIRMQ-DSNPYSFQSDVYAFGIVLYELMTGQLPYSN 218 >4AN9-A nrPDB Length = 301 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 72/258 (27%), Positives = 125/258 (48%), Gaps = 19/258 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G G V H+ +G +A K+++ + IR+ +I RE+Q L P+I+ Sbjct: 17 LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPYIVG 71 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC-HRHMVVH 137 Y + + + ME++ GG L + K GR+ E ++ ++ + Y +H ++H Sbjct: 72 FYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 131 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 RD+KP N+L+++ K+ DFG+S + D E G+ +Y +PE + G Y+ + DI Sbjct: 132 RDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPERLQGTHYS-VQSDI 189 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL-----LMHMLQVD 252 WS G+ L + G P + L I V P L +V +L + L + Sbjct: 190 WSMGLSLVEMAVGRYPRPPMAIFELLDYI---VNEPPPKLPSAVFSLEFQDFVNKCLIKN 246 Query: 253 PLKRATIKDIREHEWFKQ 270 P +RA +K + H + K+ Sbjct: 247 PAERADLKQLMVHAFIKR 264 >2J0K-A nrPDB Length = 656 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 72/252 (28%), Positives = 117/252 (46%), Gaps = 8/252 (3%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 LG +G G FG V G + + +AV I + S V K +E ++ F HPHI Sbjct: 394 LGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHI 453 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHRHMV 135 +KL VI T +++ME + GEL ++ ++ + L+ Q+ +A+ Y Sbjct: 454 VKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRF 512 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS--PNYAAPEVISGRLYAGP 193 VHRD+ NVL+ A K+ DFGLS M D + + S G + APE I+ R + Sbjct: 513 VHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSA 572 Query: 194 EVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQV 251 D+W GV ++ +L G PF + +I G +P ++ +L+ Sbjct: 573 S-DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAY 631 Query: 252 DPLKRATIKDIR 263 DP +R +++ Sbjct: 632 DPSRRPRFTELK 643 >2WQN-A nrPDB Length = 310 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 75/262 (28%), Positives = 117/262 (44%), Gaps = 14/262 (5%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G + ++ + +G G F +V L G VA+K + + +EI L Sbjct: 27 GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLL 86 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-----VEEMEARRLFQQI 123 K HP++IK Y + +V+E G+L I KH + + E + F Q+ Sbjct: 87 KQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMI-KHFKKQKRLIPERTVWKYFVQL 145 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAP 182 SA+++ H V+HRD+KP NV + A K+ D GL S S G+P Y +P Sbjct: 146 CSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRGGVFYIP---EYL 237 E I Y + DIWS G +LY + PF D ++ +L KKI Y P ++ Sbjct: 206 ERIHENGY-NFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIE-QCDYPPLPSDHY 263 Query: 238 NRSVATLLMHMLQVDPLKRATI 259 + + L+ + DP KR + Sbjct: 264 SEELRQLVNMCINPDPEKRPDV 285 >3C51-A nrPDB Length = 543 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 78/266 (29%), Positives = 128/266 (48%), Gaps = 21/266 (7%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G FG+V + + TG A K LN+++++ E + L I+ L Sbjct: 192 VLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLA 251 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEE-----MEARRLF--QQILSAVDYCHRH 133 T TD +VM ++GG++ +I V+E E R +F QI+S +++ H+ Sbjct: 252 YAFETKTDLCLVMTIMNGGDIRYHIYN---VDEDNPGFQEPRAIFYTAQIVSGLEHLHQR 308 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVISGRLYAG 192 +++RDLKPENVLLD N +I+D GL+ + G+ + G+P + APE++ G Y Sbjct: 309 NIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEY-D 367 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YIPEYLNRSVATLLMHM 248 VD ++ GV LY ++ PF K+++ V P+ + + + Sbjct: 368 FSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEAL 427 Query: 249 LQVDPLKRATIKD-----IREHEWFK 269 LQ DP KR +D +R H F+ Sbjct: 428 LQKDPEKRLGFRDGSCDGLRTHPLFR 453 >5KKR-C nrPDB Length = 395 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 110/218 (50%), Gaps = 12/218 (5%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDV 57 + +KQK G +K + LG G G V H+ +G +A K+++ + IR+ Sbjct: 56 LTQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--- 111 Query: 58 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 117 +I RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E Sbjct: 112 --QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG 169 Query: 118 RLFQQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 176 ++ ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ Sbjct: 170 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGT 228 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 +Y +PE + G Y+ + DIWS G+ L + G P Sbjct: 229 RSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPI 265 >6CTH-A nrPDB Length = 309 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 105/198 (53%), Gaps = 12/198 (6%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G FG V G + + +AVK ++R S + + E++ + RH +++KL Sbjct: 21 NKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGIKEYASEVKIISRLRHKNLVKL 77 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-RLFQQILSAVDYCHR---HMV 135 + +V E+++ G L +I K + E R R+ + + SA+ Y H H V Sbjct: 78 IGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCV 137 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPEVI-SGRLYAG 192 +HRD+K N++LD+ NAK+ DFGL+ ++ + L+ + G+ Y APE + SG+ A Sbjct: 138 LHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK--AS 195 Query: 193 PEVDIWSCGVILYALLCG 210 E D++S GV+ + G Sbjct: 196 KESDVYSFGVVALEIASG 213 >5B2L-A nrPDB Length = 324 Score = 88.6 bits (218), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 76/266 (28%), Positives = 117/266 (43%), Gaps = 26/266 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKIL--------NRQKIRSLDVVGKIKREIQNLKLFRH 73 +G GT G+V + TGH +AVK + N++ + LDVV LK Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV---------LKSHDC 75 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC-HR 132 P+I++ + T TD F+ ME + G + E ++ I+ A+ Y + Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEK 135 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 H V+HRD+KP N+LLD K+ DFG+S + D + S G Y APE I Sbjct: 136 HGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTK 195 Query: 193 PEVDI----WSCGVILYALLCGTLPFDD--EHVPTLFKKIRGGVFYIPEYLNRS--VATL 244 P+ DI WS G+ L L G P+ + L K ++ +P ++ S + Sbjct: 196 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 255 Query: 245 LMHMLQVDPLKRATIKDIREHEWFKQ 270 + L D KR + EH + K+ Sbjct: 256 VKDCLTKDHRKRPKYNKLLEHSFIKR 281 >2F9G-A nrPDB Length = 353 Score = 88.6 bits (218), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 122/304 (40%), Gaps = 56/304 (18%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD---VVGKIKREIQNLKLFR 72 + L LG G +G V H+ TG VA+K KI D + REI+ LK F+ Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIK-----KIEPFDKPLFALRTLREIKILKHFK 67 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDY----ICKHGRVEEMEARRLFQQILSAVD 128 H +II ++ I P F E EL + + + + Q L AV Sbjct: 68 HENIITIFN-IQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVK 126 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + E ++ R Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 189 LYAGPEV-----------DIWSCGVILYAL---------------------LCGTLPFDD 216 Y PEV D+WSCG IL L + GT D+ Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 217 EHVPTLFKKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREH 265 + + R + +P Y +N LL ML DP KR T K+ EH Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 266 EWFK 269 + + Sbjct: 307 PYLQ 310 >5TQX-A nrPDB Length = 655 Score = 88.6 bits (218), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 100/215 (46%), Gaps = 20/215 (9%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + + + LG G FG V + +H+ K+A+K + S + EIQ +K H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLE--LSTKNRERWCHEIQIMKKLNH 65 Query: 74 PHIIKLYQVISTPTDF--------FMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQ 122 +++K V P + + MEY SGG+L + K ++E + L Sbjct: 66 ANVVKACDV---PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 179 I S + Y H + ++HRDLKPEN++L + KI D G + + GE G+ Y Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQY 182 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 APE+ + Y VD WS G +++ + G PF Sbjct: 183 LAPELFENKPYTAT-VDYWSFGTMVFECIAGYRPF 216 >5HVK-A nrPDB Length = 315 Score = 88.2 bits (217), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 74/277 (26%), Positives = 129/277 (46%), Gaps = 39/277 (14%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 G+ LG G FG+ H+ TG + +K L R + K E++ ++ HP+++K Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLK---EVKVMRCLEHPNVLK 75 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ-------ILSAVDYCH 131 V+ + EY+ GG L G ++ M+++ + Q I S + Y H Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTL------RGIIKSMDSQYPWSQRVSFAKDIASGMAYLH 129 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG----EFLR-----------TSCGS 176 ++HR+L N L+ + N +ADFGL+ +M D E LR T G+ Sbjct: 130 SMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGN 189 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK---KIRGGV-FY 232 P + APE+I+GR Y +VD++S G++L ++ G + D +++P +RG + Y Sbjct: 190 PYWMAPEMINGRSYD-EKVDVFSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRY 247 Query: 233 IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 P S + + +DP KR + ++ W + Sbjct: 248 CPPNCPPSFFPITVRCCDLDPEKRPSF--VKLEHWLE 282 >4XEY-B nrPDB Length = 408 Score = 88.2 bits (217), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 65/250 (26%), Positives = 120/250 (48%), Gaps = 13/250 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V G + VAVK L + V + +E +K +HP++++L Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVMKEIKHPNLVQLLG 188 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F+++ E+++ G L DY+ C V + + QI SA++Y + +HRD Sbjct: 189 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD 248 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L+ + K+ADFGLS +M+ G+ G+ + APE ++ ++ + D Sbjct: 249 LAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKFS-IKSD 306 Query: 197 IWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPL 254 +W+ GV+L+ + G P+ + +++ + PE V L+ Q +P Sbjct: 307 VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS 366 Query: 255 KRATIKDIRE 264 R + +I + Sbjct: 367 DRPSFAEIHQ 376 >4EWQ-A nrPDB Length = 383 Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 64/200 (32%), Positives = 100/200 (50%), Gaps = 13/200 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V TG +VAVK L+R +S+ + RE++ LK +H ++I L Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLSR-PFQSIIHAKRTYRELRLLKHMKHENVIGLLD 111 Query: 82 VISTP-------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 V TP D ++V ++ G +L + I K ++ + + L QIL + Y H Sbjct: 112 VF-TPARSLEEFNDVYLVT-HLMGADL-NNIVKCQKLTDDHVQFLIYQILRGLKYIHSAD 168 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ ++ Sbjct: 169 IIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWMHYNQT 226 Query: 195 VDIWSCGVILYALLCGTLPF 214 VDIWS G I+ LL G F Sbjct: 227 VDIWSVGCIMAELLTGRTLF 246 >5HIE-A nrPDB Length = 302 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 109/216 (50%), Gaps = 18/216 (8%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D + G +G +G G+FG V G+ VAVK+L Q++++ K E+ Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKGKWH---GDVAVKMLTPQQLQAF------KNEVGV 80 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSA 126 L+ RH +I+ L+ ST +V ++ G L+ ++ + E ++ + +Q Sbjct: 81 LRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 139 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS----DGEFLRTSCGSPNYAAP 182 +DY H ++HRDLK N+ L + KI DFGL+ + S +F + S GS + AP Sbjct: 140 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS-GSILWMAP 198 Query: 183 EVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDD 216 EVI + + D+++ G++LY L+ G LP+ + Sbjct: 199 EVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN 234 >6NPU-A nrPDB Length = 298 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 65/250 (26%), Positives = 120/250 (48%), Gaps = 13/250 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V G + VAVK L + V + +E +K +HP++++L Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVMKEIKHPNLVQLLG 89 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F+++ E+++ G L DY+ C V + + QI SA++Y + +HRD Sbjct: 90 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD 149 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L+ + K+ADFGLS +M+ G+ G+ + APE ++ ++ + D Sbjct: 150 LAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKFS-IKSD 207 Query: 197 IWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPL 254 +W+ GV+L+ + G P+ + +++ + PE V L+ Q +P Sbjct: 208 VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS 267 Query: 255 KRATIKDIRE 264 R + +I + Sbjct: 268 DRPSFAEIHQ 277 >3EQC-A nrPDB Length = 360 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 110/218 (50%), Gaps = 12/218 (5%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDV 57 + +KQK G +K + LG G G V H+ +G +A K+++ + IR+ Sbjct: 21 LTQKQKV-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRN--- 76 Query: 58 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 117 +I RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E Sbjct: 77 --QIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILG 134 Query: 118 RLFQQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 176 ++ ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ Sbjct: 135 KVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGT 193 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 +Y +PE + G Y+ + DIWS G+ L + G P Sbjct: 194 RSYMSPERLQGTHYS-VQSDIWSMGLSLVEMAVGRYPI 230 >2FO0-A nrPDB Length = 495 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 120/250 (48%), Gaps = 13/250 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G +G+V G + VAVK L + V + +E +K +HP++++L Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVMKEIKHPNLVQLLG 280 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F+++ E+++ G L DY+ C V + + QI SA++Y + +HR+ Sbjct: 281 VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRN 340 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L+ + K+ADFGLS +M+ G+ G+ + APE ++ ++ + D Sbjct: 341 LAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKFS-IKSD 398 Query: 197 IWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPL 254 +W+ GV+L+ + G P+ + +++ + PE V L+ Q +P Sbjct: 399 VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS 458 Query: 255 KRATIKDIRE 264 R + +I + Sbjct: 459 DRPSFAEIHQ 468 >4HVI-A nrPDB Length = 314 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/200 (34%), Positives = 99/200 (49%), Gaps = 19/200 (9%) Query: 22 LGVGTFGKVKIGEHQL----TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 LG G FG V++ + TG VAVK L D +REIQ LK I+ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS---GPDQQRDFQREIQILKALHSDFIV 74 Query: 78 KLYQVISTP--TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF---QQILSAVDYCHR 132 K V P +VMEY+ G L D++ +H ++A RL QI ++Y Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH--RARLDASRLLLYSSQICKGMEYLGS 132 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSP-NYAAPEVISGR 188 VHRDL N+L+++ + KIADFGL+ ++ D +R SP + APE +S Sbjct: 133 RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDN 192 Query: 189 LYAGPEVDIWSCGVILYALL 208 +++ + D+WS GV+LY L Sbjct: 193 IFSR-QSDVWSFGVVLYELF 211 >1G3N-A nrPDB Length = 326 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 63/197 (31%), Positives = 101/197 (51%), Gaps = 12/197 (6%) Query: 22 LGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE--IQNLKLFRHPHIIK 78 +G G +GKV K + + G VA+K + Q + I+ +++L+ F HP++++ Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 Query: 79 LYQVISTP-----TDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 L+ V + T +V E+V D + + G E +FQ +L +D+ H Sbjct: 79 LFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ-LLRGLDFLH 137 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APEV+ YA Sbjct: 138 SHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYA 197 Query: 192 GPEVDIWSCGVILYALL 208 P VD+WS G I + Sbjct: 198 TP-VDLWSVGCIFAEMF 213 >4IC8-A nrPDB Length = 442 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 81/340 (23%), Positives = 139/340 (40%), Gaps = 73/340 (21%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL---FR 72 Y + +T+G G +G V +LTG +VA+K + + DVV KR ++ LK+ F+ Sbjct: 57 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPN----AFDVVTNAKRTLRELKILKHFK 112 Query: 73 HPHIIKLYQVISTPTDF------FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 H +II + ++ + ++V++ + +L I + R Q+L Sbjct: 113 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRG 171 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 + Y H V+HRDLKP N+L++ + KI DFG++ R C SP Y E Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMA---------RGLCTSPAEHQYFMTE 222 Query: 184 VISGRLYAGPE-----------VDIWSCGVILYALLCGTLPFDDEHV------------- 219 ++ R Y PE +D+WS G I +L F ++ Sbjct: 223 YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGT 282 Query: 220 --PTLFK-----KIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKD 261 P + + ++R + +P +R +LL ML+ +P R + Sbjct: 283 PSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAA 342 Query: 262 IREHEWFKQ-----DLPSYLFPEDPSYDANVIDDEAVKEV 296 H + + D P P D ++D + E +KE Sbjct: 343 ALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEA 382 >3V5Q-A nrPDB Length = 297 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 82/282 (29%), Positives = 122/282 (43%), Gaps = 30/282 (10%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGE-HQLTGHK----VAVKILNRQKIRSLDVVGKI 61 H +K VL LG G FGKV + E + L+ K VAVK L K +L Sbjct: 8 HVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL---KDPTLAARKDF 64 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG------------ 109 +RE + L +H HI+K Y V MV EY+ G+L ++ HG Sbjct: 65 QREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPR 124 Query: 110 ----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165 + + + QI S + Y VHRDL N L+ A++ KI DFG+S + Sbjct: 125 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 184 Query: 166 DGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLP-FDDEHVP 220 ++ R + + PE I R + E D+WS GVIL+ + G P F + Sbjct: 185 STDYYRVGGHTMLPIRWMPPESIMYRKFT-TESDVWSFGVILWEIFTYGKQPWFQLSNTE 243 Query: 221 TLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 + +G V P + V +++ Q +P +R IK+I Sbjct: 244 VIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 285 >1S9I-A nrPDB Length = 354 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 58/197 (29%), Positives = 101/197 (51%), Gaps = 11/197 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILN---RQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G G V +H+ +G +A K+++ + IR+ +I RE+Q L P+I+ Sbjct: 24 LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRN-----QIIRELQVLHECNSPYIVG 78 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC-HRHMVVH 137 Y + + + ME++ GG L + + R+ E ++ +L + Y +H ++H Sbjct: 79 FYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMH 138 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 RD+KP N+L+++ K+ DFG+S + D + G+ +Y APE + G Y+ + DI Sbjct: 139 RDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSYMAPERLQGTHYS-VQSDI 196 Query: 198 WSCGVILYALLCGTLPF 214 WS G+ L L G P Sbjct: 197 WSMGLSLVELAVGRYPI 213 >2Y6O-A nrPDB Length = 291 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 68/250 (27%), Positives = 125/250 (50%), Gaps = 26/250 (10%) Query: 21 TLGVGTFGKVKIGEHQLTGHK---VAVKIL-----NRQKIRSLDVVGKIKREIQNLKLFR 72 +GVG FG+V G ++ G + VA+K L ++Q+ L E + F Sbjct: 21 VIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLS-------EASIMGQFD 73 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCH 131 HP+II L V++ ++ EY+ G L ++ K+ GR ++ + + I S + Y Sbjct: 74 HPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLS 133 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAAPEVISG 187 VHRDL N+L+++++ K++DFG+S ++ D E T+ G + APE I+ Sbjct: 134 DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAY 193 Query: 188 RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 R + D+WS G++++ ++ G P+ D + K I G + +P ++ +A + Sbjct: 194 RKFTSAS-DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG-YRLPPPMDCPIA---L 248 Query: 247 HMLQVDPLKR 256 H L +D ++ Sbjct: 249 HQLMLDCWQK 258 >4ZSG-A nrPDB Length = 347 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 100/217 (46%), Gaps = 37/217 (17%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL---FR 72 Y + +T+G G +G V +LTG +VA+K + + DVV KR ++ LK+ F+ Sbjct: 9 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPN----AFDVVTNAKRTLRELKILKHFK 64 Query: 73 HPHIIKLYQVISTPTDF------FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 H +II + ++ + ++V++ + +L I + R Q+L Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLYQLLRG 123 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 + Y H V+HRDLKP N+L++ + KI DFG++ R C SP Y E Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMA---------RGLCTSPAEHQYFMTE 174 Query: 184 VISGRLYAGPE-----------VDIWSCGVILYALLC 209 ++ R Y PE +D+WS G I +L Sbjct: 175 YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA 211 >2PL0-A nrPDB Length = 289 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 111/219 (50%), Gaps = 16/219 (7%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 L + LG G FG+V +G + GH KVAVK L +Q S D E +K +H + Sbjct: 27 LVERLGAGQFGEVWMGYY--NGHTKVAVKSL-KQGSMSPDA---FLAEANLMKQLQHQRL 80 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ---QILSAVDYCHRH 133 ++LY V+ T +++ EY+ G L D++ ++ + +L QI + + Sbjct: 81 VRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGIK-LTINKLLDMAAQIAEGMAFIEER 138 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPEVISGRLYA 191 +HRDL+ N+L+ ++ KIADFGL+ ++ D E+ R P + APE I+ + Sbjct: 139 NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFT 198 Query: 192 GPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG 229 + D+WS G++L ++ G +P+ P + + + G Sbjct: 199 -IKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERG 236 >4PDO-A nrPDB Length = 299 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 124/259 (47%), Gaps = 26/259 (10%) Query: 21 TLGVGTFGKVKIGEHQLTGHK----VAVKILN-----RQKIRSLDVVGKIKREIQNLKLF 71 +G G FG+V G + + K VA+K L +Q++ L G + + F Sbjct: 41 VIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQ-------F 93 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDYC 130 H +II+L VIS ++ EY+ G L ++ K G ++ + + I + + Y Sbjct: 94 SHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAAPEVIS 186 VHRDL N+L+++++ K++DFGLS ++ D E T+ G + APE IS Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS 213 Query: 187 GRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLN--RSVAT 243 R + D+WS G++++ ++ G P+ + + K I G F +P ++ ++ Sbjct: 214 YRKFTSAS-DVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDG-FRLPTPMDCPSAIYQ 271 Query: 244 LLMHMLQVDPLKRATIKDI 262 L+M Q + +R DI Sbjct: 272 LMMQCWQQERARRPKFADI 290 >3MIA-A nrPDB Length = 351 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 133/310 (42%), Gaps = 65/310 (20%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G GTFG+V H+ TG KVA+K +L + + REI+ L+L +H +++ L Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL--REIKILQLLKHENVVNLI 82 Query: 81 QVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 ++ T ++V ++ G L + + K E +R+ Q +L+ + Y Sbjct: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNGLYY 139 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----------Y 179 HR+ ++HRD+K NVL+ K+ADFGL+ S PN Y Sbjct: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS-----LAKNSQPNRYTNRVVTLWY 194 Query: 180 AAPEVISGRLYAGPEVDIWSCGVI---------------------LYALLCGTLP----- 213 PE++ G GP +D+W G I L + LCG++ Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 214 -FDDEHVPTLFKKIRGGVFYIPEYLNRSV-----ATLLMHMLQVDPLKRATIKDIREHEW 267 D+ + + ++G + + L V L+ +L +DP +R D H++ Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 Query: 268 FKQD-LPSYL 276 F D +PS L Sbjct: 315 FWSDPMPSDL 324 >3GC9-A nrPDB Length = 370 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 88/325 (27%), Positives = 139/325 (42%), Gaps = 44/325 (13%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I L Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSR-PFQSLIHARRTYRELRLLKHLKHENVIGLLD 94 Query: 82 VISTPT---DFFMV--MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 V + T DF V + + G +L + I K + + + L Q+L + Y H ++ Sbjct: 95 VFTPATSIEDFSEVYLVTTLMGADL-NNIVKSQALSDEHVQFLVYQLLRGLKYIHSAGII 153 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ VD Sbjct: 154 HRDLKPSNVAVNEDSELRILDFGLARQAD--EEMTGYVATRWYRAPEIMLNWMHYNQTVD 211 Query: 197 IWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGGVFYIPEY 236 IWS G I+ LL G F K+I R + +P Sbjct: 212 IWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPM 271 Query: 237 LNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285 + +++ LL ML +D +R + + H +F Q PE YD Sbjct: 272 PQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDE 331 Query: 286 NVIDDEAVKEVCEKF-ECTESEVMN 309 +V EA + E++ E T EV++ Sbjct: 332 SV---EAKERTLEEWKELTYQEVLS 353 >4JLC-A nrPDB Length = 657 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 100/215 (46%), Gaps = 18/215 (8%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++L D LG G V G H+ TG AVK+ N I L V RE + LK H + Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFN--NISFLRPVDVQMREFEVLKKLNHKN 67 Query: 76 IIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 130 I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 68 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 127 Query: 131 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + +VHRD+KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 128 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 187 Query: 187 GRLYA-------GPEVDIWSCGVILYALLCGTLPF 214 + G VD+WS GV Y G+LPF Sbjct: 188 RAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >4MYG-A nrPDB Length = 372 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 67/206 (32%), Positives = 100/206 (48%), Gaps = 14/206 (6%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 YV +G G +G V + +G KVA+K L+R +S + RE+ LK +H + Sbjct: 45 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSR-PFQSEIFAKRAYRELLLLKHMQHEN 103 Query: 76 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVD 128 +I L V + + DF++VM ++ D G E + + L Q+L + Sbjct: 104 VIGLLDVFTPASSLRNFYDFYLVMPFMQT----DLQKIMGMEFSEEKIQYLVYQMLKGLK 159 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Y H VVHRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI Sbjct: 160 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR-HADAE-MTGYVVTRWYRAPEVILSW 217 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPF 214 ++ VDIWS G I+ +L G F Sbjct: 218 MHYNQTVDIWSVGCIMAEMLTGKTLF 243 >4AU8-A nrPDB Length = 296 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 129/291 (44%), Gaps = 44/291 (15%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIKREIQNLKLFRHPHII 77 + +G GT+G V +++ T VA+K R ++ D V REI LK +H +I+ Sbjct: 12 EKIGEGTYGTVFKAKNRETHEIVALK---RVRLDDDDEGVPSSALREICLLKELKHKNIV 68 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 +L+ V+ + +V E+ + +G ++ + Q+L + +CH V+H Sbjct: 69 RLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 128 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRLYAG 192 RDLKP+N+L++ + K+ADFGL+ + C S Y P+V+ G Sbjct: 129 RDLKPQNLLINRNGELKLADFGLARAFG----IPVRCYSAEVVTLWYRPPDVLFGAKLYS 184 Query: 193 PEVDIWSCGVILYALLCGTLPF-----DDEHVPTLFKKIRG-------GVFYIPEY---- 236 +D+WS G I L P D+ + +F+ + + +P+Y Sbjct: 185 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 244 Query: 237 --------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 273 LN + LL ++L+ +P++R + ++ +H +F P Sbjct: 245 MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 295 >5J5T-A nrPDB Length = 370 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 67/259 (25%), Positives = 117/259 (45%), Gaps = 11/259 (4%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G GT+G V + TG A+K++ + VV ++EI +K +HP+I+ + Sbjct: 12 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVV---QQEIIMMKDCKHPNIVAYFG 68 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 ++ ME+ GG L D G + E++ + ++ L + Y H +HRD+K Sbjct: 69 SYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIK 128 Query: 142 PENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGPE--VDIW 198 N+LL + + K+ADFG+S ++ R + G+P + APEV + G D+W Sbjct: 129 GANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYNQLCDLW 188 Query: 199 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR-----SVATLLMHMLQVDP 253 + G+ L P D H + F P+ ++ S + L +P Sbjct: 189 AVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNP 248 Query: 254 LKRATIKDIREHEWFKQDL 272 KR T + + +H + Q L Sbjct: 249 KKRPTAEKLLQHPFVTQHL 267 >2HK5-A nrPDB Length = 270 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 69/252 (27%), Positives = 124/252 (49%), Gaps = 13/252 (5%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 L LG G FG+V + + KVAVK + K S+ V + E +K +H ++ Sbjct: 19 LEKKLGAGQFGEVWMATYN-KHTKVAVKTM---KPGSMSVEAFLA-EANVMKTLQHDKLV 73 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQ-QILSAVDYCHRHMV 135 KL+ V+ T +++ E+++ G L D++ G + + F QI + + + Sbjct: 74 KLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 132 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPEVISGRLYAGP 193 +HRDL+ N+L+ A + KIADFGL+ ++ D E+ R P + APE I+ + Sbjct: 133 IHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFT-I 191 Query: 194 EVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQV 251 + D+WS G++L ++ G +P+ P + + + RG PE + ++M + Sbjct: 192 KSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKN 251 Query: 252 DPLKRATIKDIR 263 P +R T + I+ Sbjct: 252 RPEERPTFEYIQ 263 >4Y83-A nrPDB Length = 332 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 60/196 (30%), Positives = 97/196 (49%), Gaps = 11/196 (5%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 D + G FGKV + + T ++A K++ + + DV EIQ FRH +I +L Sbjct: 79 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDV------EIQ--ACFRHENIAEL 130 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + + ME GG + + + G + E E + + +L +D+ H V+H D Sbjct: 131 YGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHD 190 Query: 140 LKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 +KP N++ + A + DFGLS M D F + G+ Y +PEVI R ++ + DI+ Sbjct: 191 IKPSNIVFMS-TKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHST-KADIY 248 Query: 199 SCGVILYALLCGTLPF 214 S G L + GT P+ Sbjct: 249 SLGATLIHMQTGTPPW 264 >2PMN-X nrPDB Length = 348 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/312 (24%), Positives = 127/312 (40%), Gaps = 54/312 (17%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKV------------KIGEHQLTGHKVAVKILN 48 + EK K+ I Y + TL G F K+ K E L K N Sbjct: 23 VKEKDKY-----INDYRIIRTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSN 77 Query: 49 RQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGEL--FD--- 103 KI K E+Q + ++ + + +I+ + +++ EY+ + FD Sbjct: 78 NDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYF 137 Query: 104 ------YICKHGRVEEMEARRLFQQILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIA 156 Y C + + + + +L++ Y H + HRD+KP N+L+D + K++ Sbjct: 138 FVLDKNYTC---FIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLS 194 Query: 157 DFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR-LYAGPEVDIWSCGVILYALLCGTLPFD 215 DFG S M D + ++ S G+ + PE S Y G +VDIWS G+ LY + +PF Sbjct: 195 DFGESEYMVDKK-IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS 253 Query: 216 DE-HVPTLFKKIRGGVFYIP-------------------EYLNRSVATLLMHMLQVDPLK 255 + + LF IR P +L+ L L+ +P + Sbjct: 254 LKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAE 313 Query: 256 RATIKDIREHEW 267 R T +D +HEW Sbjct: 314 RITSEDALKHEW 325 >4AT3-A nrPDB Length = 299 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 79/275 (28%), Positives = 120/275 (43%), Gaps = 27/275 (9%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGE-HQLTGHK----VAVKILNRQKIRSLDVVGKIKREI 65 +K + VL LG G FGKV + E + L + VAVK L K S + RE Sbjct: 10 IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTL---KDASDNARKDFHREA 66 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-------------RVE 112 + L +H HI+K Y V MV EY+ G+L ++ HG + Sbjct: 67 ELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 126 Query: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 172 + + + QQI + + Y VHRDL N L+ ++ KI DFG+S + ++ R Sbjct: 127 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRV 186 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-R 227 + + PE I R + E D+WS GV+L+ + G P+ + + I + Sbjct: 187 GGHTMLPIRWMPPESIMYRKFT-TESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 245 Query: 228 GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G V P + V L++ Q +P R IK I Sbjct: 246 GRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 280 >1U59-A nrPDB Length = 287 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 69/218 (31%), Positives = 103/218 (47%), Gaps = 16/218 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 LG G FG V+ G +++ + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADT-EEMMREAQIMHQLDNPYIVRL 75 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM---EARRLFQQILSAVDYCHRHMVV 136 V +VME GG L ++ G+ EE+ L Q+ + Y V Sbjct: 76 IGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP--NYAAPEVISGRLYAG 192 HRDL NVLL AKI+DFGLS + D + S G + APE I+ R ++ Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 192 Query: 193 PEVDIWSCGVILY-ALLCGTLPFDDEHVPTLFKKIRGG 229 D+WS GV ++ AL G P+ P + I G Sbjct: 193 -RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 229 >4UY9-A nrPDB Length = 323 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 102/220 (46%), Gaps = 25/220 (11%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL-DVVGKIKREIQNLK 69 + L + +G+G FGKV G +VAVK + + +++E + Sbjct: 6 IDFAELTLEEIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFA 63 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 + +HP+II L V + +VME+ GG L + + R+ QI ++Y Sbjct: 64 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNY 122 Query: 130 CHRHMVV---HRDLKPENVLLDAHMN--------AKIADFGLSNMMSDGEFLRTS----C 174 H +V HRDLK N+L+ + KI DFGL+ E+ RT+ Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAA 177 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 G+ + APEVI +++ D+WS GV+L+ LL G +PF Sbjct: 178 GTYAWMAPEVIRASMFSKGS-DVWSYGVLLWELLTGEVPF 216 >5AMN-A nrPDB Length = 299 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 78/268 (29%), Positives = 121/268 (45%), Gaps = 23/268 (8%) Query: 15 HYVLGDTLGVGTFGKV-KIGEHQLTGH----KVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + VLG TLG G FGKV K L G VAVK+L S + + E LK Sbjct: 24 NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLK 81 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM--EARRLFQ------ 121 HPH+IKLY S +++EY G L ++ + +V + R L Sbjct: 82 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISF 141 Query: 122 --QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGS-- 176 QI + Y +VHRDL N+L+ KI+DFGLS ++ + +++ S G Sbjct: 142 AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP 201 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIP 234 + A E + +Y + D+WS GV+L+ ++ G P+ LF ++ G P Sbjct: 202 VKWMAIESLFDHIYT-TQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERP 260 Query: 235 EYLNRSVATLLMHMLQVDPLKRATIKDI 262 + + + L++ + +P KR DI Sbjct: 261 DNCSEEMYRLMLQCWKQEPDKRPVFADI 288 >4P5Q-A nrPDB Length = 361 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 105/205 (51%), Gaps = 18/205 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHK---VAVKILN---RQKIRSLDVVGKIKREIQNLKLFRHPH 75 +G G FG+V G +L K VA+K L +K R D +G E + F HP+ Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRR-DFLG----EASIMGQFDHPN 95 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRHM 134 II+L V++ +V EY+ G L ++ KH + ++ + + I S + Y Sbjct: 96 IIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMG 155 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAAPEVISGRLY 190 VHRDL N+L+++++ K++DFGLS ++ D E T+ G + +PE I+ R + Sbjct: 156 YVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKF 215 Query: 191 AGPEVDIWSCGVILYALLC-GTLPF 214 D+WS G++L+ ++ G P+ Sbjct: 216 TSAS-DVWSYGIVLWEVMSYGERPY 239 >6NT9-A nrPDB Length = 742 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 102/216 (47%), Gaps = 20/216 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 74 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 65 Query: 75 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 129 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125 Query: 130 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + +VHR++KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 126 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 185 Query: 186 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 214 + G VD+WS GV Y G+LPF Sbjct: 186 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 >4BGQ-A nrPDB Length = 304 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 101/211 (47%), Gaps = 5/211 (2%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G V +LG +G G +G V H+ T VA+K + + +V RE++ L Sbjct: 8 GNVMNKFEILG-VVGEGAYGVVLKCRHKETHEIVAIKKFKDSE-ENEEVKETTLRELKML 65 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 + + +I++L + ++V EYV L V + + Q++ A+ Sbjct: 66 RTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIH 125 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNYAAPEVIS 186 +CH++ +VHRD+KPEN+L+ + K+ DFG + +S+G + Y +PE++ Sbjct: 126 WCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLL 185 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDE 217 G Y G VD+WS G IL L G F E Sbjct: 186 GAPY-GKSVDMWSVGCILGELSDGQPLFPGE 215 >3DTC-A nrPDB Length = 271 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 102/220 (46%), Gaps = 25/220 (11%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL-DVVGKIKREIQNLK 69 + L + +G+G FGKV G +VAVK + + +++E + Sbjct: 4 IDFAELTLEEIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFA 61 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 + +HP+II L V + +VME+ GG L + + R+ QI ++Y Sbjct: 62 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMNY 120 Query: 130 CHRHMVV---HRDLKPENVLLDAHMN--------AKIADFGLSNMMSDGEFLRTS----C 174 H +V HRDLK N+L+ + KI DFGL+ E+ RT+ Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAA 175 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 G+ + APEVI +++ D+WS GV+L+ LL G +PF Sbjct: 176 GAYAWMAPEVIRASMFSKGS-DVWSYGVLLWELLTGEVPF 214 >2UV2-A nrPDB Length = 325 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 103/198 (52%), Gaps = 12/198 (6%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 ++G+ LG G FGKV +++ T A K+++ + L+ EI L HP+I Sbjct: 41 IIGE-LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELE---DYMVEIDILASCDHPNI 96 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMV 135 +KL + ++++E+ +GG + + + R + E + + + +Q L A++Y H + + Sbjct: 97 VKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKI 156 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVI-----SGRL 189 +HRDLK N+L + K+ADFG+S + R S G+P + APEV+ R Sbjct: 157 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 216 Query: 190 YAGPEVDIWSCGVILYAL 207 Y + D+WS G+ L + Sbjct: 217 Y-DYKADVWSLGITLIEM 233 >3DKO-A nrPDB Length = 318 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 110/220 (50%), Gaps = 16/220 (7%) Query: 21 TLGVGTFGKVKIGEHQLTGHK-VAVKILNRQKIRSLDVVGKIKR----EIQNLKLFRHPH 75 +G G FG+V G +L G + VAV I K + K +R E + F HP+ Sbjct: 50 VIGAGEFGEVCSGRLKLPGKRDVAVAI----KTLKVGYTEKQRRDFLCEASIMGQFDHPN 105 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRHM 134 ++ L V++ +V+E++ G L ++ KH G+ ++ + + I + + Y Sbjct: 106 VVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMG 165 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAAPEVISGRLY 190 VHRDL N+L+++++ K++DFGLS ++ D E + T+ G + APE I R + Sbjct: 166 YVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKF 225 Query: 191 AGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG 229 D+WS G++++ ++ G P+ D + K I G Sbjct: 226 TSAS-DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG 264 >3E7O-A nrPDB Length = 360 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 95/202 (47%), Gaps = 17/202 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G G V + G VAVK L+R ++ + RE+ LK H +II L Sbjct: 30 IGSGAQGIVCAAFDTVLGINVAVKKLSR-PFQNQTHAKRAYRELVLLKCVNHKNIISLLN 88 Query: 82 VISTPT-------DFFMVMEYVSGGELFDYICK--HGRVEEMEARRLFQQILSAVDYCHR 132 V TP D ++VME + +C+ H ++ L Q+L + + H Sbjct: 89 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIHMELDHERMSYLLYQMLCGIKHLHS 142 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRDLKP N+++ + KI DFGL+ S + + Y APEVI G Y Sbjct: 143 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGMGYK- 201 Query: 193 PEVDIWSCGVILYALLCGTLPF 214 VDIWS G I+ L+ G++ F Sbjct: 202 ENVDIWSVGCIMGELVKGSVIF 223 >4EUU-A nrPDB Length = 319 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 102/216 (47%), Gaps = 20/216 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 74 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 67 Query: 75 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 129 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 68 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 127 Query: 130 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + +VHR++KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 187 Query: 186 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 214 + G VD+WS GV Y G+LPF Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4UYA-A nrPDB Length = 340 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 77/266 (28%), Positives = 114/266 (42%), Gaps = 27/266 (10%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHPHI 76 L + +G G FG+V Q G +VAVK + + + ++RE + + RHP+I Sbjct: 30 LKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNI 87 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM-- 134 I+L V +V+E+ GG L + R+ QI + Y H Sbjct: 88 IELRGVCLQQPHLCLVLEFARGGALNRALAGR-RIPPHVLVNWAVQIARGMLYLHEEAFV 146 Query: 135 -VVHRDLKPENVLLDAHM--------NAKIADFGLSNMMSDGEFLRT----SCGSPNYAA 181 ++HRDLK N+LL + KI DFGL+ E+ RT + G+ + A Sbjct: 147 PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR-----EWHRTTKMATAGAYAWMA 201 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD--DEHVPTLFKKIRGGVFYIPEYLNR 239 PEVI L++ DIWS GV+L+ LL G +P+ D + IP Sbjct: 202 PEVIKSSLFSKGS-DIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPE 260 Query: 240 SVATLLMHMLQVDPLKRATIKDIREH 265 A L+ Q DP R + I E Sbjct: 261 PFAKLMKECWQQDPHIRPSFALILEQ 286 >4EUT-A nrPDB Length = 396 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 102/216 (47%), Gaps = 20/216 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 74 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 67 Query: 75 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 129 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 68 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 127 Query: 130 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + +VHR++KP N++ D K+ DFG + + D E + G+ Y P++ Sbjct: 128 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY 187 Query: 186 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 214 + G VD+WS GV Y G+LPF Sbjct: 188 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4YFF-A nrPDB Length = 311 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 100/201 (49%), Gaps = 8/201 (3%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G G+FGKV G + VA+K S V RE+ L HP +I+ Sbjct: 48 EIIGSGSFGKVYKG--RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 105 Query: 80 Y-QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHR--HMV 135 ++ P+ F +V +Y+SGG LF + + R+ +++++ + + ++Y H + Sbjct: 106 VGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPI 165 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSPNYAAPEVISGRLYAGP 193 +HRDL N+LL +A +ADFG S + D + + G+ + APEV + Sbjct: 166 IHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTI 225 Query: 194 EVDIWSCGVILYALLCGTLPF 214 + D++S + L+ +L G +PF Sbjct: 226 KADVFSYALCLWEILTGEIPF 246 >5UIU-A nrPDB Length = 323 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 107/211 (50%), Gaps = 16/211 (7%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ-KIRSLDVVGKIKREIQNLKLFRHPH 75 V G+ +G G FG V G + VAVK L I + ++ + +EI+ + +H + Sbjct: 50 VGGNKMGEGGFGVVYKG--YVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 107 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGR--VEEMEARRLFQQILSAVDYCHR 132 +++L S D +V Y+ G L D + C G + ++ Q + +++ H Sbjct: 108 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 167 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-----CGSPNYAAPEVISG 187 + +HRD+K N+LLD AKI+DFGL+ + +F +T G+ Y APE + G Sbjct: 168 NHHIHRDIKSANILLDEAFTAKISDFGLAR--ASEKFAQTVMTSRIVGTTAYMAPEALRG 225 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEH 218 + P+ DI+S GV+L ++ G LP DEH Sbjct: 226 EIT--PKSDIYSFGVVLLEIITG-LPAVDEH 253 >3QGY-A nrPDB Length = 286 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 111/241 (46%), Gaps = 13/241 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G FG V +G + L KVA+K + + D + E + + HP +++LY Sbjct: 35 IGSGQFGLVHLG-YWLNKDKVAIKTIKEGSMSEDDFI----EEAEVMMKLSHPKLVQLYG 89 Query: 82 VISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 V +V E++ G L DY+ + G + + + Y V+HRDL Sbjct: 90 VCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDL 149 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDI 197 N L+ + K++DFG++ + D ++ +S G+ +A+PEV S Y+ D+ Sbjct: 150 AARNCLVGENQVIKVSDFGMTRFVLDDQY-TSSTGTKFPVKWASPEVFSFSRYSSKS-DV 207 Query: 198 WSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPLK 255 WS GV+++ + G +P+++ + + I G Y P + V ++ H + P Sbjct: 208 WSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPED 267 Query: 256 R 256 R Sbjct: 268 R 268 >3OZ6-A nrPDB Length = 388 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 70/250 (28%), Positives = 108/250 (43%), Gaps = 31/250 (12%) Query: 9 GRVK---IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 GRV + Y L LG G +G V + TG VAVK + S D + REI Sbjct: 1 GRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDA-QRTFREI 59 Query: 66 QNL-KLFRHPHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122 L +L H +I+ L V+ D ++V +Y+ + + +E + + + Q Sbjct: 60 MILTELSGHENIVNLLNVLRADNDRDVYLVFDYMETD--LHAVIRANILEPVHKQYVVYQ 117 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS--------------------- 161 ++ + Y H ++HRD+KP N+LL+A + K+ADFGLS Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENT 177 Query: 162 -NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP 220 N D L + Y APE++ G +D+WS G IL +LCG F Sbjct: 178 ENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTM 237 Query: 221 TLFKKIRGGV 230 ++I G + Sbjct: 238 NQLERIIGVI 247 >2W1I-A nrPDB Length = 326 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 100/205 (48%), Gaps = 15/205 (7%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQ----LTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 H LG G FG V++ + TG VAVK L L +REI+ LK Sbjct: 42 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR---DFEREIEILKS 98 Query: 71 FRHPHIIKLYQVISTP--TDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAV 127 +H +I+K V + + ++MEY+ G L DY+ KH R++ ++ + QI + Sbjct: 99 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 158 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSPN---YAAPE 183 +Y +HRDL N+L++ KI DFGL+ ++ D E+ + + + APE Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 218 Query: 184 VISGRLYAGPEVDIWSCGVILYALL 208 ++ ++ D+WS GV+LY L Sbjct: 219 SLTESKFSVAS-DVWSFGVVLYELF 242 >2OZO-A nrPDB Length = 613 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 103/218 (47%), Gaps = 16/218 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 LG G FG V+ G +++ + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM---EARRLFQQILSAVDYCHRHMVV 136 V +VME GG L ++ G+ EE+ L Q+ + Y V Sbjct: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP--NYAAPEVISGRLYAG 192 HR+L NVLL AKI+DFGLS + D + S G + APE I+ R ++ Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 Query: 193 PEVDIWSCGVILY-ALLCGTLPFDDEHVPTLFKKIRGG 229 D+WS GV ++ AL G P+ P + I G Sbjct: 519 -RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 >5O2C-A nrPDB Length = 380 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/308 (22%), Positives = 140/308 (45%), Gaps = 36/308 (11%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY- 80 LG G F V G T +VA L +K+ + + K E + LK +HP+I++ Y Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFYD 91 Query: 81 ---QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM--V 135 ++ +V E ++ G L Y+ + ++ R +QIL + + H + Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 151 Query: 136 VHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 +HRDLK +N+ + + KI D GL+ +M F ++ G+P + APE+ + Sbjct: 152 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS-FAKSVIGTPEFMAPEMYEE--HYDES 208 Query: 195 VDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGVFYIPEYLNR----SVATLLMHML 249 VD+++ G+ + + P+ + ++ +++K+ G+ P N+ V ++ + Sbjct: 209 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGI--KPASFNKVTDPEVKEIIEGCI 266 Query: 250 QVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 309 + + +R +I+D+ H +F +D + E+ E+ +C+ S + Sbjct: 267 RQNKSERLSIRDLLNHAFFAEDTGLRV------------------ELAEEDDCSNSSLAL 308 Query: 310 SLYSGDPQ 317 L+ DP+ Sbjct: 309 RLWVEDPK 316 >4QNY-A nrPDB Length = 354 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 104/207 (50%), Gaps = 11/207 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHK-VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y+L +G G++G V + ++ VA+K +N++ + + +I REI+ L F Sbjct: 22 YLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDD 81 Query: 75 HIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +II L ++ TP D F++VM+ + +L + + E + Q L A+ Sbjct: 82 NIIGLRNIL-TPEDPENFDHFYIVMD-IMETDLKQVLRSGQELTEAHIQFFIYQALRALH 139 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD-GEFLRTSCGSPNYAAPEVISG 187 H V+HRD+ P N+L++ + + KI DFGL+ +D GE++ Y APE++ Sbjct: 140 IIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVME 199 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF 214 ++D+W G IL LL G+ P Sbjct: 200 DKDYSAQIDVWGIGCILGELL-GSRPL 225 >1UA2-A nrPDB Length = 346 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/224 (30%), Positives = 104/224 (46%), Gaps = 32/224 (14%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIK-REI 65 D + + Y D LG G F V + T VA+K + + + D + + REI Sbjct: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV----EEMEARRLFQ 121 + L+ HP+II L ++ +V +++ + I K + ++A L Sbjct: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN--- 178 L ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ S GSPN Sbjct: 122 --LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAY 169 Query: 179 --------YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 Y APE++ G G VD+W+ G IL LL +PF Sbjct: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 >6O8B-A nrPDB Length = 665 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 101/216 (46%), Gaps = 20/216 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK-IRSLDVVGKIKREIQNLKLFRHP 74 ++L D LG G V G H+ TG A+K+ N +R +DV RE + LK H Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ---MREFEVLKKLNHK 73 Query: 75 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDY 129 +I+KL+ + +T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 74 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 133 Query: 130 CHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + +VHR++KP N++ D K+ DFG + + D E G+ Y P++ Sbjct: 134 LRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMY 193 Query: 186 SGRLYA-------GPEVDIWSCGVILYALLCGTLPF 214 + G VD+WS GV Y G+LPF Sbjct: 194 ERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 >4GS6-A nrPDB Length = 315 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 72/255 (28%), Positives = 118/255 (46%), Gaps = 26/255 (10%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G G FG V + + VA+K + + R +V E++ L HP+I+KL Sbjct: 15 EVVGRGAFGVV--CKAKWRAKDVAIKQIESESERKAFIV-----ELRQLSRVNHPNIVKL 67 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGR-----VEEMEARRLFQQILSAVDYCHR-- 132 Y P +VMEY GG L++ + HG A Q V Y H Sbjct: 68 YGACLNPV--CLVMEYAEGGSLYNVL--HGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQ 123 Query: 133 -HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRDLKP N+LL A KI DFG + + + + GS + APEV G Y Sbjct: 124 PKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT--HMTNNKGSAAWMAPEVFEGSNY 181 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPT---LFKKIRGGVFYIPEYLNRSVATLLMH 247 + + D++S G+IL+ ++ PFD+ P ++ G + + L + + +L+ Sbjct: 182 S-EKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTR 240 Query: 248 MLQVDPLKRATIKDI 262 DP +R ++++I Sbjct: 241 CWSKDPSQRPSMEEI 255 >3IO7-A nrPDB Length = 313 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 100/205 (48%), Gaps = 15/205 (7%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQ----LTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 H LG G FG V++ + TG VAVK L L +REI+ LK Sbjct: 29 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR---DFEREIEILKS 85 Query: 71 FRHPHIIKLYQVISTP--TDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAV 127 +H +I+K V + + ++MEY+ G L DY+ KH R++ ++ + QI + Sbjct: 86 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 145 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSPN---YAAPE 183 +Y +HRDL N+L++ KI DFGL+ ++ D E+ + + + APE Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 205 Query: 184 VISGRLYAGPEVDIWSCGVILYALL 208 ++ ++ D+WS GV+LY L Sbjct: 206 SLTESKFSVAS-DVWSFGVVLYELF 229 >4YHJ-A nrPDB Length = 584 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 121/261 (46%), Gaps = 14/261 (5%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G FG+V + + TG A K L +++I+ E + L+ + ++ L Sbjct: 192 VLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLA 251 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 138 T +V+ ++GG+L +I G E R +F ++ ++ R +V+R Sbjct: 252 YAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYR 311 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-GPEVDI 197 DLKPEN+LLD + +I+D GL+ + +G+ +R G+ Y APEV++ Y P D Sbjct: 312 DLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSP--DW 369 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLF----KKIRGGVFYIPEYLNRSVATLLMHMLQVDP 253 W G ++Y ++ G PF + ++I+ E + ++ +L +P Sbjct: 370 WGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNP 429 Query: 254 LKRATIK-----DIREHEWFK 269 KR + +++H FK Sbjct: 430 SKRLGCRGEGAAGVKQHPVFK 450 >2R2P-A nrPDB Length = 295 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 111/221 (50%), Gaps = 18/221 (8%) Query: 21 TLGVGTFGKVKIGEHQLTGHK---VAVKILN---RQKIRSLDVVGKIKREIQNLKLFRHP 74 +G G FG+V G +L G + VA+K L +K R D +G E + F HP Sbjct: 29 VIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRR-DFLG----EASIMGQFDHP 83 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRH 133 +II L V++ +V EY+ G L ++ K+ G+ ++ + + I + + Y Sbjct: 84 NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDM 143 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAAPEVISGRL 189 VHRDL N+L+++++ K++DFGLS ++ D E T+ G + APE I+ R Sbjct: 144 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK 203 Query: 190 YAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG 229 + D+WS G++++ ++ G P+ + + K + G Sbjct: 204 FTSAS-DVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEG 243 >5O2B-A nrPDB Length = 285 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 62/262 (23%), Positives = 125/262 (47%), Gaps = 18/262 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY- 80 LG G F V G T +VA L +K+ + + K E + LK +HP+I++ Y Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFYD 82 Query: 81 ---QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM--V 135 ++ +V E ++ G L Y+ + ++ R +QIL + + H + Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPI 142 Query: 136 VHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 +HRDLK +N+ + + KI D GL+ +M F ++ G+P + APE+ + Sbjct: 143 IHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS-FAKSVIGTPEFMAPEMYEE--HYDES 199 Query: 195 VDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGVFYIPEYLNR----SVATLLMHML 249 VD+++ G+ + + P+ + ++ +++K+ G+ P N+ V ++ + Sbjct: 200 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGI--KPASFNKVTDPEVKEIIEGCI 257 Query: 250 QVDPLKRATIKDIREHEWFKQD 271 + + +R +I+D+ H +F +D Sbjct: 258 RQNKSERLSIRDLLNHAFFAED 279 >4XI2-A nrPDB Length = 446 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 107/200 (53%), Gaps = 14/200 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG VK G+ + + VA+K++ R+ S D + + + NL H +++LY Sbjct: 195 LGTGQFGVVKYGKWR-GQYDVAIKMI-REGSMSEDEFIEEAKVMMNLS---HEKLVQLYG 249 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F++ EY++ G L +Y+ +H R + + + + + A++Y +HRD Sbjct: 250 VCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQLLEMCKDVCEAMEYLESKQFLHRD 308 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L++ K++DFGLS + D E+ +S GS ++ PEV+ ++ + D Sbjct: 309 LAARNCLVNDQGVVKVSDFGLSRYVLDDEYT-SSVGSKFPVRWSPPEVLMYSKFSS-KSD 366 Query: 197 IWSCGVILYALLC-GTLPFD 215 IW+ GV+++ + G +P++ Sbjct: 367 IWAFGVLMWEIYSLGKMPYE 386 >5A46-A nrPDB Length = 386 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 125/279 (44%), Gaps = 36/279 (12%) Query: 17 VLGDTLGVGTFGKVKIGE---------HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 VLG LG G FG+V + E +++T KVAVK+L + + E++ Sbjct: 43 VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT--KVAVKMLKSDATEK--DLSDLISEMEM 98 Query: 68 LKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI----------C---KHGRVEE 113 +K+ +H +II L + ++++EY S G L +Y+ C H E+ Sbjct: 99 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 158 Query: 114 MEARRLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL 170 + ++ L Q+ ++Y +HRDL NVL+ KIADFGL+ + ++ Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 171 RTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI 226 + + + APE + R+Y + D+WS GV+L+ + G P+ V LFK + Sbjct: 219 KKTTNGRLPVKWMAPEALFDRIYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 277 Query: 227 RGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 + G P + ++ P +R T K + E Sbjct: 278 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 316 >6DBM-A nrPDB Length = 318 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 73/201 (36%), Positives = 95/201 (47%), Gaps = 22/201 (10%) Query: 22 LGVGTFGKVKI----GEHQLTGHKVAVKILNRQ---KIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV + + TG VAVK L + RS K+EI L+ H Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRS-----GWKQEIDILRTLYHE 93 Query: 75 HIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HIIK + +VMEYV G L DY+ +H + + QQI + Y H Sbjct: 94 HIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHS 152 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EF--LRTSCGSPNYA-APEVISG- 187 +HRDL NVLLD KI DFGL+ + +G E+ +R SP + APE + Sbjct: 153 QHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEY 212 Query: 188 RLYAGPEVDIWSCGVILYALL 208 + Y D+WS GV LY LL Sbjct: 213 KFYYAS--DVWSFGVTLYELL 231 >4NEU-A nrPDB Length = 333 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 73/277 (26%), Positives = 125/277 (45%), Gaps = 26/277 (9%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 ++K ++ L G FGKV + H+ G + + + ++ + E + + Sbjct: 20 KMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVY--KGPNCIEHNEALLEEAKMMN 77 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 RH ++KL VI + +VMEY+ G L + R+ +I+ + Y Sbjct: 78 RLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCY 137 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN--MMS-------------DGEFLRTSC 174 H V+H+DLKPEN+L+D + KIAD GL++ M S DG + + Sbjct: 138 LHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT-AKKNG 196 Query: 175 GSPNYAAPEVISGRLYAGP--EVDIWSCGVILYALLCGTLPFDDEHVP-TLFKKIRGG-- 229 G+ Y APE ++ + A P + D++S V+L+A+ P+++ L I+ G Sbjct: 197 GTLYYMAPEHLND-VNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNR 255 Query: 230 --VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 V I EY R + +L+ + +P R T I E Sbjct: 256 PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEE 292 >6E4F-A nrPDB Length = 290 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 120/246 (48%), Gaps = 15/246 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG VK G+ + + VA+K++ + + + + K + NL H +++LY Sbjct: 39 LGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIEEAKV-MMNLS---HEKLVQLYG 93 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F++ EY++ G L +Y+ +H R + + + + + A++Y +HRD Sbjct: 94 VCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQLLEMCKDVCEAMEYLESKQFLHRD 152 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L++ K++DFGLS + D E+ +S GS ++ PEV+ ++ D Sbjct: 153 LAARNCLVNDQGVVKVSDFGLSRYVLDDEY-TSSVGSKFPVRWSPPEVLMYSKFSSKS-D 210 Query: 197 IWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPL 254 IW+ GV+++ + G +P++ + I G+ Y P + V T++ Sbjct: 211 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKAD 270 Query: 255 KRATIK 260 +R T K Sbjct: 271 ERPTFK 276 >3QUP-A nrPDB Length = 323 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 74/275 (26%), Positives = 116/275 (42%), Gaps = 34/275 (12%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + LG LG G FG V+ E QL KVAVK+L I S D+ + RE +K Sbjct: 24 QFTLGRMLGKGEFGSVR--EAQLKQEDGSFVKVAVKMLKADIIASSDI-EEFLREAACMK 80 Query: 70 LFRHPHIIKLYQV---------ISTPTDFFMVMEYVSGGELFDYICKHGRVEE------- 113 F HPH+ KL V + P +++ ++ G+L ++ R+ E Sbjct: 81 EFDHPHVAKLVGVSLRSRAKGRLPIP---MVILPFMKHGDLHAFLLA-SRIGENPFNLPL 136 Query: 114 MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS 173 R I ++Y +HRDL N +L M +ADFGLS + G++ R Sbjct: 137 QTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQG 196 Query: 174 CGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG 229 C S + A E ++ LY D+W+ GV ++ ++ G P+ ++ + GG Sbjct: 197 CASKLPVKWLALESLADNLYT-VHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG 255 Query: 230 -VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 P V L+ DP +R + +R Sbjct: 256 NRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLR 290 >5AWM-A nrPDB Length = 394 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 89/342 (26%), Positives = 137/342 (40%), Gaps = 64/342 (18%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G G V +T VA+K L+R +++ + RE + +KL H +II L Sbjct: 52 IGSGAQGIVCAAYDTITQQNVAIKKLSR-PFQNVTHAKRAYREFKLMKLVNHKNIIGLLN 110 Query: 82 VISTPT-------DFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 TP D ++VME + ++ H R+ L Q+L + + H Sbjct: 111 AF-TPQRNLEEFQDVYLVMELMDANLCQVIQMDLDHDRMS-----YLLYQMLCGIKHLHS 164 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRDLKP N+++ A KI DFGL+ + + Y APEVI G Y Sbjct: 165 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT- 223 Query: 193 PEVDIWSCGVILYALLCGTLPF-DDEHV--------------PTLFKK----IRGGVFYI 233 VDIWS G I+ ++ G + F +H+ P+ ++ +R V Sbjct: 224 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 283 Query: 234 PEYLNRS------------------------VATLLMHMLQVDPLKRATIKDIREHEWFK 269 P Y S LL ML +DP +R ++ + +HE+ Sbjct: 284 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYIN 343 Query: 270 --QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 309 D P YD +V DE V + E EVM+ Sbjct: 344 VWYDAEEVDAPAPEPYDHSV--DEREHTVEQWKELIYEEVMD 383 >4Y93-A nrPDB Length = 446 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 107/200 (53%), Gaps = 14/200 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G FG VK G+ + + VA+K++ + + + + K + NL H +++LY Sbjct: 196 LGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFIEEAKV-MMNLS---HEKLVQLYG 250 Query: 82 VISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 V + F++ EY++ G L +Y+ +H R + + + + + A++Y +HRD Sbjct: 251 VCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQLLEMCKDVCEAMEYLESKQFLHRD 309 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 L N L++ K++DFG++ + D E+ +S GS +A+PEV+ ++ + D Sbjct: 310 LAARNCLVNDQGVVKVSDFGMTRYVLDDEYT-SSTGSKFPVKWASPEVLMYSKFSS-KSD 367 Query: 197 IWSCGVILYALLC-GTLPFD 215 IW+ GV+++ + G +P++ Sbjct: 368 IWAFGVLMWEIYSLGKMPYE 387 >3KUL-B nrPDB Length = 325 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 103/207 (49%), Gaps = 22/207 (10%) Query: 22 LGVGTFGKVKIGEHQLTGHK---VAVKILN-----RQKIRSLDVVGKIKREIQNLKLFRH 73 +G G G+V G ++ G + VA+K L RQ+ L E + F H Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLS-------EASIMGQFDH 109 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHR 132 P+II+L V++ +V EY+ G L ++ H G+ M+ + + + + + Y Sbjct: 110 PNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSD 169 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS---DGEFLRTSCGSP-NYAAPEVISGR 188 VHRDL NVL+D+++ K++DFGLS ++ D + T P + APE I+ R Sbjct: 170 LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFR 229 Query: 189 LYAGPEVDIWSCGVILYALLC-GTLPF 214 ++ D+WS GV+++ +L G P+ Sbjct: 230 TFSSAS-DVWSFGVVMWEVLAYGERPY 255 >3GQL-A nrPDB Length = 326 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 125/279 (44%), Gaps = 36/279 (12%) Query: 17 VLGDTLGVGTFGKVKIGE---------HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 VLG LG G FG+V + E +++T KVAVK+L + + E++ Sbjct: 31 VLGKPLGEGAFGQVVLAEAIGLDKDKPNRVT--KVAVKMLKSDATEK--DLSDLISEMEM 86 Query: 68 LKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI----------C---KHGRVEE 113 +K+ +H +II L + ++++EY S G L +Y+ C H E+ Sbjct: 87 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 146 Query: 114 MEARRLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL 170 + ++ L Q+ ++Y +HRDL NVL+ KIADFGL+ + ++ Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 171 RTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI 226 + + + APE + R+Y + D+WS GV+L+ + G P+ V LFK + Sbjct: 207 KKTTNGRLPVKWMAPEALFDRIYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 265 Query: 227 RGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 + G P + ++ P +R T K + E Sbjct: 266 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 304 >6HXF-B nrPDB Length = 302 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/194 (29%), Positives = 98/194 (50%), Gaps = 13/194 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD--VVGKIKREIQNLKLFRHPHIIKL 79 LG G FGKV +++ TG A K++ + L+ +V EI+ L HP+I+KL Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-----EIEILATCDHPYIVKL 81 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVHR 138 ++++E+ GG + + + R + E + + + +Q+L A+++ H ++HR Sbjct: 82 LGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHR 141 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAGP---- 193 DLK NVL+ + ++ADFG+S R S G+P + APEV+ Sbjct: 142 DLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDY 201 Query: 194 EVDIWSCGVILYAL 207 + DIWS G+ L + Sbjct: 202 KADIWSLGITLIEM 215 >5FM2-A nrPDB Length = 355 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/280 (27%), Positives = 121/280 (43%), Gaps = 37/280 (13%) Query: 17 VLGDTLGVGTFGKV-KIGEHQLTGHK----VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 VLG TLG G FGKV K L G VAVK+L S + + E LK Sbjct: 67 VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLSEFNVLKQV 124 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV----------------EEME 115 HPH+IKLY S +++EY G L ++ + +V + + Sbjct: 125 NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPD 184 Query: 116 ARRLFQ--------QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSD 166 R L QI + Y +VHRDL N+L+ KI+DFGLS ++ + Sbjct: 185 ERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE 244 Query: 167 GEFLRTSCGS--PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF 223 +++ S G + A E + +Y + D+WS GV+L+ ++ G P+ LF Sbjct: 245 DSYVKRSQGRIPVKWMAIESLFDHIYT-TQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF 303 Query: 224 KKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 ++ G P+ + + L++ + +P KR DI Sbjct: 304 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >6DBN-A nrPDB Length = 316 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/200 (32%), Positives = 105/200 (52%), Gaps = 18/200 (9%) Query: 22 LGVGTFGKVKIG----EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 LG G FGKV++ E TG +VAVK L + + + +K+EI+ L+ H +I+ Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES--GGNHIADLKKEIEILRNLYHENIV 100 Query: 78 KLYQVISTP---TDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRH 133 K Y+ I T ++ME++ G L +Y+ K+ ++ + + QI +DY Sbjct: 101 K-YKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 159 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEF--LRTSCGSPNYA-APE-VISGR 188 VHRDL NVL+++ KI DFGL+ + +D E+ ++ SP + APE ++ + Sbjct: 160 QYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSK 219 Query: 189 LYAGPEVDIWSCGVILYALL 208 Y D+WS GV L+ LL Sbjct: 220 FYIAS--DVWSFGVTLHELL 237 >4TPT-A nrPDB Length = 303 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 98/212 (46%), Gaps = 27/212 (12%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHPHII 77 G+ LG G FG+ H+ TG + +K L IR + K E++ ++ HP+++ Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKEL----IRCDEETQKTFLTEVKVMRSLDHPNVL 60 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 K V+ ++ EY+ GG L D++ + R + I S + Y H ++H Sbjct: 61 KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIH 120 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMM---------------------SDGEFLRTSCGS 176 RDL N L+ +ADFGLS ++ +D + T G+ Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALL 208 P + APE+++G+ Y VDI+S G++L ++ Sbjct: 181 PYWMAPEMLNGKSY-DETVDIFSFGIVLCEII 211 >4OLI-A nrPDB Length = 645 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/201 (35%), Positives = 95/201 (47%), Gaps = 22/201 (10%) Query: 22 LGVGTFGKVKI----GEHQLTGHKVAVKILNRQ---KIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV + + TG VAVK L + RS K+EI L+ H Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRS-----GWKQEIDILRTLYHE 415 Query: 75 HIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HIIK + +VMEYV G L DY+ +H + + QQI + Y H Sbjct: 416 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHS 474 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EF--LRTSCGSPNYA-APEVISG- 187 +HR+L NVLLD KI DFGL+ + +G E+ +R SP + APE + Sbjct: 475 QHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEY 534 Query: 188 RLYAGPEVDIWSCGVILYALL 208 + Y D+WS GV LY LL Sbjct: 535 KFYYA--SDVWSFGVTLYELL 553 Score = 35.4 bits (80), Expect = 0.064, Method: Compositional matrix adjust. Identities = 63/262 (24%), Positives = 105/262 (40%), Gaps = 24/262 (9%) Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCH 131 H H+ ++ V + MV EYV G L ++ + G V + QQ+ SA+ Y Sbjct: 125 HTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLE 184 Query: 132 RHMVVHRDLKPENVLLDAHMNA-------KIAD--FGLSNMMSDGEFLRTSCGSPNYAAP 182 +VH ++ N+LL A K++D GL + + R + AP Sbjct: 185 NKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP-----WLAP 239 Query: 183 EVISGRLYA-GPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 E + G + +D W G L + G P P+ + +PE Sbjct: 240 ECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRS-PSEKEHFYQRQHRLPEPSCPQ 298 Query: 241 VATLLMHMLQVDPLKRATIKDI-REHEWFK-QDLPSYLF--PEDPSYDANVIDDEAVKEV 296 +ATL L +P +R + + I R+ + +L L P+ P+ D V +K++ Sbjct: 299 LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI 358 Query: 297 CEKFECTESEVMNSLYSGDPQD 318 + E +V SLY DP + Sbjct: 359 RDLGEGHFGKV--SLYCYDPTN 378 >5NGU-A nrPDB Length = 381 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 98/216 (45%), Gaps = 13/216 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V L +VA+K ++ + ++ + REI+ L FRH +II + Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQT--YCQRTLREIKILLRFRHENIIGIND 107 Query: 82 VISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 +I PT D ++V + + +L+ + K + QIL + Y H V+ Sbjct: 108 IIRAPTIEQMKDVYIVQDLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE----FLRTSCGSPNYAAPEVISGRLYAG 192 HRDLKP N+LL+ + KI DFGL+ + FL + Y APE++ Sbjct: 166 HRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYT 225 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG 228 +DIWS G IL +L F +H I G Sbjct: 226 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 261 >3TT0-A nrPDB Length = 382 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 72/279 (25%), Positives = 124/279 (44%), Gaps = 36/279 (12%) Query: 17 VLGDTLGVGTFGKVKIGE---------HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 VLG LG G FG+V + E +++T KVAVK+L + + E++ Sbjct: 72 VLGKPLGEGAFGQVVLAEAIGLDKDKPNRVT--KVAVKMLKSDATEK--DLSDLISEMEM 127 Query: 68 LKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-------------KHGRVEE 113 +K+ +H +II L + ++++EY S G L +Y+ H E+ Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQ 187 Query: 114 MEARRLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL 170 + ++ L Q+ ++Y +HRDL NVL+ KIADFGL+ + ++ Sbjct: 188 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 247 Query: 171 RTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI 226 + + + APE + R+Y + D+WS GV+L+ + G P+ V LFK + Sbjct: 248 KKTTNGRLPVKWMAPEALFDRIYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 306 Query: 227 RGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 + G P + ++ P +R T K + E Sbjct: 307 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 345 >4E20-A nrPDB Length = 290 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 72/201 (35%), Positives = 96/201 (47%), Gaps = 22/201 (10%) Query: 22 LGVGTFGKVKI----GEHQLTGHKVAVKILNRQ---KIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV + + TG VAVK L ++RS +REI+ L+ H Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRS-----GWQREIEILRTLYHE 70 Query: 75 HIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HI+K + +VMEYV G L DY+ +H V + QQI + Y H Sbjct: 71 HIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEGMAYLHA 129 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EF--LRTSCGSPNYA-APEVI-SG 187 +HR L NVLLD KI DFGL+ + +G E+ +R SP + APE + Sbjct: 130 QHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEC 189 Query: 188 RLYAGPEVDIWSCGVILYALL 208 + Y D+WS GV LY LL Sbjct: 190 KFYYAS--DVWSFGVTLYELL 208 >4PWN-A nrPDB Length = 274 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 61/265 (23%), Positives = 125/265 (47%), Gaps = 23/265 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY- 80 +G G+F V G T +VA L +K+ + + K E + LK +HP+I++ Y Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER-QRFKEEAEMLKGLQHPNIVRFYD 76 Query: 81 ---QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM--V 135 + +V E ++ G L Y+ + ++ R +QIL + + H + Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPI 136 Query: 136 VHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 +HRDLK +N+ + + KI D GL+ + F ++ G+P + APE+ + Sbjct: 137 IHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEEKY--DES 194 Query: 195 VDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGV-------FYIPEYLNRSVATLLM 246 VD+++ G+ + + P+ + ++ +++++ GV IPE V ++ Sbjct: 195 VDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPE-----VKEIIE 249 Query: 247 HMLQVDPLKRATIKDIREHEWFKQD 271 ++ + +R +IKD+ H +F+++ Sbjct: 250 GCIRQNKDERYSIKDLLNHAFFQEE 274 >1K9A-A nrPDB Length = 450 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 67/250 (26%), Positives = 119/250 (47%), Gaps = 15/250 (6%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 T+G G FG V +G+++ G+KVAVK I++ E + RH ++++L Sbjct: 200 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 252 Query: 81 QVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ-QILSAVDYCHRHMVVH 137 VI ++V EY++ G L DY+ GR V + F + A++Y + VH Sbjct: 253 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 313 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 369 Query: 198 WSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPLK 255 WS G++L+ + G +P+ + + ++ G P+ +V ++ + +D Sbjct: 370 WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAAT 429 Query: 256 RATIKDIREH 265 R T +RE Sbjct: 430 RPTFLQLREQ 439 >2VWV-A nrPDB Length = 302 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 104/222 (46%), Gaps = 24/222 (10%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILN-----RQKIRSLDVVGKIK 62 + + + + + +G G FG+V G + G K VA+K L RQ+ L Sbjct: 13 IDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLS------ 66 Query: 63 REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQ 121 E + F HP+II+L V++ ++ E++ G L ++ G+ ++ + + Sbjct: 67 -EASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLR 125 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN--- 178 I S + Y VHRDL N+L+++++ K++DFGLS + + T S Sbjct: 126 GIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKI 185 Query: 179 ---YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 + APE I+ R + D WS G++++ ++ G P+ D Sbjct: 186 PIRWTAPEAIAFRKFTSAS-DAWSYGIVMWEVMSFGERPYWD 226 >4M7I-A nrPDB Length = 299 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 80/288 (27%), Positives = 127/288 (44%), Gaps = 47/288 (16%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKIL---NRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G FG V ++++ A+K + NR+ R K+ RE++ L HP I++ Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELARE-----KVMREVKALAKLEHPGIVR 67 Query: 79 LYQVI-----------STPTDFFMV-MEYVSGGELFDYICKHGRVEEME---ARRLFQQI 123 + S+P + + M+ L D++ +EE E +F QI Sbjct: 68 YFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQI 127 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT----------- 172 AV++ H ++HRDLKP N+ K+ DFGL M E +T Sbjct: 128 AEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARH 187 Query: 173 --SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDD--EHVPTL--FKKI 226 G+ Y +PE I G Y+ +VDI+S G+IL+ LL PF E V TL + + Sbjct: 188 TGQVGTKLYMSPEQIHGNSYSH-KVDIFSLGLILFELL---YPFSTQMERVRTLTDVRNL 243 Query: 227 RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ-DLP 273 + + +Y V ++ ML P++R +I E+ F+ D P Sbjct: 244 KFPPLFTQKYPCEYV--MVQDMLSPSPMERPEAINIIENAVFEDLDFP 289 >5Y86-A nrPDB Length = 588 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 67/216 (31%), Positives = 116/216 (53%), Gaps = 24/216 (11%) Query: 16 YVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKIL------NRQKIRSLDVVGKIKREIQNL 68 Y + +G G+FG+V ++ +H+L + VA+K++ +RQ + ++ +K++ + Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQY-VALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG 267 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQILS 125 + ++I + + + M E +S +L++ I K+ G ++ R+ Q IL Sbjct: 268 SM----NVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQL-VRKFAQSILQ 321 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 ++D H++ ++H DLKPEN+LL H + K+ DFG S + + L T S Y APE Sbjct: 322 SLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPE 379 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGT--LPFDDE 217 +I G Y+ P +DIWS G IL LL G P +DE Sbjct: 380 IILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDE 414 >3OMV-A nrPDB Length = 307 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 106/217 (48%), Gaps = 25/217 (11%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 ++ +L +G G+FG V G+ VAVKIL + + + + E+ L+ Sbjct: 33 IEASEVMLSTRIGSGSFGTVYKGKWH---GDVAVKIL-KVVDPTPEQFQAFRNEVAVLRK 88 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------QIL 124 RH +I+ L+ T + +V ++ G L+ KH V+E + + +FQ Q Sbjct: 89 TRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLY----KHLHVQETKFQ-MFQLIDIARQTA 142 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM---MSDGEFLRTSCGSPNYAA 181 +DY H ++HRD+K N+ L + KI DFGL+ + S + + GS + A Sbjct: 143 QGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMA 202 Query: 182 PEVISGRLYAGP----EVDIWSCGVILYALLCGTLPF 214 PEVI R+ + D++S G++LY L+ G LP+ Sbjct: 203 PEVI--RMQDNNPFSFQSDVYSYGIVLYELMTGELPY 237 >6J5U-C nrPDB Length = 426 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 106/216 (49%), Gaps = 22/216 (10%) Query: 20 DTLGVGTFG---KVKIGEHQLTGHK------VAVKILNRQKIRSLDVVGKIKREIQNLKL 70 + LG G FG K I + LT + VAVK L + + + E+ L Sbjct: 90 NLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHK---EWLTEVNYLGQ 146 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA--VD 128 HP+++ L + + +V E++ G L +++ + G A R+ + +A + Sbjct: 147 LSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLT 206 Query: 129 YCH--RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC---GSPNYAAPE 183 + H + V++RD K N+LLDA NAK++DFGL+ G+ S G+ YAAPE Sbjct: 207 FLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPE 266 Query: 184 -VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH 218 V +GRL A + D++S GV+L L+ G D+ + Sbjct: 267 YVATGRLTA--KSDVYSFGVVLLELISGRRAMDNSN 300 >3ALO-A nrPDB Length = 327 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 21/207 (10%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH----PHII 77 +G G +G V H+ +G +AVK +IRS + K+ + +L + P+I+ Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVK-----RIRSTVDEKEQKQLLMDLDVVMRSSDCPYIV 84 Query: 78 KLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM- 134 + Y + D ++ ME +S + + Y+ + ++++ + +I A H+ Sbjct: 85 QFYGALFREGDCWICMELMSTSFDKFYKYV--YSVLDDVIPEEILGKITLATVKALNHLK 142 Query: 135 ----VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI---SG 187 ++HRD+KP N+LLD N K+ DFG+S + D G Y APE I + Sbjct: 143 ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSAS 202 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF 214 R D+WS G+ LY L G P+ Sbjct: 203 RQGYDVRSDVWSLGITLYELATGRFPY 229 >1U5R-A nrPDB Length = 348 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 57/191 (29%), Positives = 95/191 (49%), Gaps = 11/191 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G+FG V VA+K ++ +S + I +E++ L+ RHP+ I+ Sbjct: 62 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 121 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 ++VMEY G D + H + ++E+E + L + Y H H ++HRD+ Sbjct: 122 CYLREHTAWLVMEYCLGSA-SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDV 180 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI----SGRLYAGPEVD 196 K N+LL K+ DFG +++M+ + G+P + APEVI G+ Y G +VD Sbjct: 181 KAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEGQ-YDG-KVD 235 Query: 197 IWSCGVILYAL 207 +WS G+ L Sbjct: 236 VWSLGITCIEL 246 >4LQP-A nrPDB Length = 508 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/266 (22%), Positives = 104/266 (39%), Gaps = 61/266 (22%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G FG+V++ + + TG A+K L + ++ D + +K E L P ++ LY Sbjct: 110 IGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYY 169 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 +++ME++ GG+L + + E R + + A++ H+ +HR +K Sbjct: 170 SFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIK 229 Query: 142 PENVLLDAHMNAKIADFGLSN--------------------------------------- 162 P+N+L+D + K++DFGLS Sbjct: 230 PDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTTDTAN 289 Query: 163 ------------MMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV----------DIWSC 200 MS+ + ++T S A + Y PE+ D WS Sbjct: 290 KRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECDWWSL 349 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKI 226 G I+Y L G PF E ++KI Sbjct: 350 GAIMYECLIGWPPFCSETPQETYRKI 375 >2XS0-A nrPDB Length = 386 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 73/275 (26%), Positives = 121/275 (44%), Gaps = 31/275 (11%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 34 IGSGAQGIVCAAYDAILERNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIIGLLN 92 Query: 82 VISTPT-------DFFMVMEYVSGGELFDYICKHGRVEEMEARR--LFQQILSAVDYCHR 132 V TP D ++VME + +C+ ++E R L Q+L + + H Sbjct: 93 VF-TPQKSLEEFQDVYIVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 146 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 147 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGMGYK- 205 Query: 193 PEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 251 VDIWS G I+ ++ G + F +H+ K I PE++ + + Sbjct: 206 ENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK-----------L 254 Query: 252 DPLKRATIKDIREHEW--FKQDLPSYLFPEDPSYD 284 P R +++ ++ F++ P LFP D ++ Sbjct: 255 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 289 >4IDT-A nrPDB Length = 356 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 111/254 (43%), Gaps = 25/254 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V E + TG + AVK + + R+ E+ P I+ LY Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA--------EELMACAGLTSPRIVPLYG 133 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 + + ME + GG L + + G + E A Q L ++Y H ++H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 142 PENVLLDAH-MNAKIADF---------GLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +NVLL + +A + DF GL + G+++ G+ + APEV+ GR Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIP---GTETHMAPEVVLGR-SC 249 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHM 248 +VD+WS ++ +L G P+ L KI V IP A + Sbjct: 250 DAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEG 309 Query: 249 LQVDPLKRATIKDI 262 L+ +P+ R + ++ Sbjct: 310 LRKEPIHRVSAAEL 323 >2GCD-A nrPDB Length = 309 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/191 (29%), Positives = 95/191 (49%), Gaps = 11/191 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G+FG V VA+K ++ +S + I +E++ L+ RHP+ I+ Sbjct: 23 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 82 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 ++VMEY G D + H + ++E+E + L + Y H H ++HRD+ Sbjct: 83 CYLREHTAWLVMEYCLGSA-SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDV 141 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI----SGRLYAGPEVD 196 K N+LL K+ DFG +++M+ + G+P + APEVI G+ Y G +VD Sbjct: 142 KAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVILAMDEGQ-YDG-KVD 196 Query: 197 IWSCGVILYAL 207 +WS G+ L Sbjct: 197 VWSLGITCIEL 207 >4H1J-A nrPDB Length = 293 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/204 (30%), Positives = 99/204 (48%), Gaps = 9/204 (4%) Query: 17 VLGDTLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 VL LG G FG+V G + G K+ V + +K +LD K E +K HPH Sbjct: 27 VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPH 86 Query: 76 IIKLYQVIST-PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHRH 133 I+KL +I PT +++ME GEL Y+ ++ ++ L+ QI A+ Y Sbjct: 87 IVKLIGIIEEEPT--WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 144 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS--PNYAAPEVISGRLYA 191 VHRD+ N+L+ + K+ DFGLS + D ++ + S + +PE I+ R + Sbjct: 145 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFT 204 Query: 192 GPEVDIWSCGVILYALLC-GTLPF 214 D+W V ++ +L G PF Sbjct: 205 TAS-DVWMFAVCMWEILSFGKQPF 227 >1BYG-A nrPDB Length = 278 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 100/198 (50%), Gaps = 14/198 (7%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 T+G G FG V +G+++ G+KVAVK I++ E + RH ++++L Sbjct: 28 TIGKGEFGDVMLGDYR--GNKVAVKC-----IKNDATAQAFLAEASVMTQLRHSNLVQLL 80 Query: 81 QVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ-QILSAVDYCHRHMVVH 137 VI ++V EY++ G L DY+ GR V + F + A++Y + VH Sbjct: 81 GVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 140 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 RDL NVL+ AK++DFGL+ S + T + APE + + ++ + D+ Sbjct: 141 RDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEALREKKFS-TKSDV 197 Query: 198 WSCGVILYALLC-GTLPF 214 WS G++L+ + G +P+ Sbjct: 198 WSFGILLWEIYSFGRVPY 215 >4QTB-A nrPDB Length = 380 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 98/217 (45%), Gaps = 15/217 (6%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V + +VA+K ++ + REIQ L FRH ++I + Sbjct: 49 IGEGAYGMVSSAYDHVRKTRVAIKKIS--PFEHQTYCQRTLREIQILLRFRHENVIGIRD 106 Query: 82 VISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 ++ T D ++V + + +L+ + K ++ QIL + Y H V+ Sbjct: 107 ILRASTLEAMRDVYIVQDLMET-DLYK-LLKSQQLSNDHICYFLYQILRGLKYIHSANVL 164 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSCGSPNYAAPEVISGRLYA 191 HRDLKP N+L++ + KI DFGL+ ++D E FL + Y APE++ Sbjct: 165 HRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 223 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG 228 +DIWS G IL +L F +H I G Sbjct: 224 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 260 >6GVJ-A nrPDB Length = 429 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 74/269 (27%), Positives = 124/269 (46%), Gaps = 30/269 (11%) Query: 24 VGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQNL-KLFRHP-HIIK 78 +G+ G K+ Q+ K A+K +N ++ + + + EI L KL +H II+ Sbjct: 152 IGSGGSSKV--FQVLNEKKQIYAIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHSDKIIR 208 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 LY T +MVME +L ++ K ++ E + ++ +L AV H+H +VH Sbjct: 209 LYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHS 267 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVI----SGR--- 188 DLKP N L+ M K+ DFG++N M + + G+ NY PE I S R Sbjct: 268 DLKPANFLIVDGM-LKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENG 326 Query: 189 ---LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV-----FYIPEYLNRS 240 P+ D+WS G ILY + G PF + + K+ + P+ + Sbjct: 327 KSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHAIIDPNHEIEFPDIPEKD 384 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFK 269 + +L L+ DP +R +I ++ H + + Sbjct: 385 LQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >3HMP-A nrPDB Length = 342 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 25/247 (10%) Query: 43 AVKILNRQKIRSLDVVGKIKREIQNL-KLFRHP-HIIKLYQVISTPTDFFMVMEYVSGGE 100 A+K +N ++ + + + EI L KL +H II+LY T +MVME + Sbjct: 84 AIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNID 141 Query: 101 LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160 L ++ K ++ E + ++ +L AV H+H +VH DLKP N L+ M K+ DFG+ Sbjct: 142 LNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LKLIDFGI 200 Query: 161 SNMM---SDGEFLRTSCGSPNYAAPEVI----SGR------LYAGPEVDIWSCGVILYAL 207 +N M + + G+ NY PE I S R P+ D+WS G ILY + Sbjct: 201 ANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM 260 Query: 208 LCGTLPFDDEHVPTLFKKIRGGV-----FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G PF + + K+ + P+ + + +L L+ DP +R +I ++ Sbjct: 261 TYGKTPF--QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 318 Query: 263 REHEWFK 269 H + + Sbjct: 319 LAHPYVQ 325 >1AD5-A nrPDB Length = 438 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 119/251 (47%), Gaps = 21/251 (8%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 L LG G FG+V + + KVAVK + K S+ V + E +K +H ++ Sbjct: 186 LEKKLGAGQFGEVWMATYN-KHTKVAVKTM---KPGSMSVEAFLA-EANVMKTLQHDKLV 240 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQ-QILSAVDYCHRHMV 135 KL+ V+ T +++ E+++ G L D++ G + + F QI + + + Sbjct: 241 KLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNY 299 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP-NYAAPEVISGRLYAGPE 194 +HRDL+ N+L+ A + KIADFGL+ R P + APE I+ + + Sbjct: 300 IHRDLRAANILVSASLVCKIADFGLA---------RVGAKFPIKWTAPEAINFGSFT-IK 349 Query: 195 VDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVD 252 D+WS G++L ++ G +P+ P + + + RG PE + ++M + Sbjct: 350 SDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNR 409 Query: 253 PLKRATIKDIR 263 P +R T + I+ Sbjct: 410 PEERPTFEYIQ 420 >2ZMD-A nrPDB Length = 390 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 25/247 (10%) Query: 43 AVKILNRQKIRSLDVVGKIKREIQNL-KLFRHP-HIIKLYQVISTPTDFFMVMEYVSGGE 100 A+K +N ++ + + + EI L KL +H II+LY T +MVME + Sbjct: 84 AIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNID 141 Query: 101 LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160 L ++ K ++ E + ++ +L AV H+H +VH DLKP N L+ M K+ DFG+ Sbjct: 142 LNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LKLIDFGI 200 Query: 161 SNMM---SDGEFLRTSCGSPNYAAPEVI----SGR------LYAGPEVDIWSCGVILYAL 207 +N M + + G+ NY PE I S R P+ D+WS G ILY + Sbjct: 201 ANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM 260 Query: 208 LCGTLPFDDEHVPTLFKKIRGGV-----FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G PF + + K+ + P+ + + +L L+ DP +R +I ++ Sbjct: 261 TYGKTPF--QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 318 Query: 263 REHEWFK 269 H + + Sbjct: 319 LAHPYVQ 325 >2H34-A nrPDB Length = 309 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/218 (25%), Positives = 103/218 (47%), Gaps = 3/218 (1%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 + G Y L +G G G V E + VA+K+++ +++RE + Sbjct: 31 TQFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGR 90 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 + PH++ ++ ++ M ++G +L + + G + A + +QI SA+D Sbjct: 91 LQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAA 150 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSCGSPNYAAPEVISGR 188 H HRD+KPEN+L+ A A + DFG+++ +D + L + G+ Y APE S Sbjct: 151 HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS-E 209 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 226 +A DI++ +LY L G+ P+ + + + I Sbjct: 210 SHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHI 247 >4C59-A nrPDB Length = 340 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 107/233 (45%), Gaps = 53/233 (22%) Query: 69 KLFRHPHIIKLYQVIS-------TPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR---- 117 KL HP+I++ S T F+++ + G+L +++ K ME+R Sbjct: 80 KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKK------MESRGPLS 133 Query: 118 -----RLFQQILSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMS----- 165 ++F Q AV + HR ++HRDLK EN+LL K+ DFG + +S Sbjct: 134 CDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDY 193 Query: 166 ----------DGEFLRTSCGSPNYAAPEVISGRLYA----GPEVDIWSCGVILYALLCGT 211 + E R + +P Y PE+I LY+ G + DIW+ G ILY L Sbjct: 194 SWSAQRRALVEEEITRNT--TPMYRTPEIID--LYSNFPIGEKQDIWALGCILYLLCFRQ 249 Query: 212 LPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA--TLLMHMLQVDPLKRATIKDI 262 PF+D +I G + IP + + +L+ MLQV+P +R +I ++ Sbjct: 250 HPFED----GAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >5Z33-A nrPDB Length = 425 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 97/208 (46%), Gaps = 11/208 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HP 74 Y + LG G +G V + T VA+K + + + + + REI+ L+ FR H Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKI-LAKRALREIKLLQHFRGHR 91 Query: 75 HIIKLYQV-ISTPTDFFMVMEYVSGGEL-FDYICKHGR-VEEMEARRLFQQILSAVDYCH 131 +I LY + I P +F Y E I + G+ + + + QIL + Y H Sbjct: 92 NITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIH 151 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-----DGEFLRTSCGSPNYAAPEVIS 186 V+HRDLKP N+L++A KI DFGL+ S + ++ + Y APE++ Sbjct: 152 SANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIML 211 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPF 214 +D+WS G IL LL G PF Sbjct: 212 SFQSYTKAIDVWSVGCILAELLGGR-PF 238 >1JNK-A nrPDB Length = 423 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 91/342 (26%), Positives = 135/342 (39%), Gaps = 63/342 (18%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 Query: 82 VISTPT-------DFFMVMEYVSGGELFDYICKHGRVEEMEARR--LFQQILSAVDYCHR 132 V TP D ++VME + +C+ ++E R L Q+L + + H Sbjct: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK- 241 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEH---------------VPTLFKK----IRGGVFYI 233 VDIWS G I+ ++ + F P KK +R V Sbjct: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 Query: 234 PEYL-------------------NRSVAT----LLMHMLQVDPLKRATIKDIREHEWFK- 269 P+Y N+ A+ LL ML +DP KR ++ D +H + Sbjct: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 Query: 270 -QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 D P YD + DE + E E EVMNS Sbjct: 362 WYDPAEVEAPPPQIYDKQL--DEREHTIEEWKELIYKEVMNS 401 >5KMM-A nrPDB Length = 329 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 123/289 (42%), Gaps = 36/289 (12%) Query: 17 VLGDTLGVGTFGKVKIGE-HQLTGHK----VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 VL LG G FGKV + E H L + VAVK L K S +RE + L + Sbjct: 38 VLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL---KEASESARQDFQREAELLTML 94 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-------------- 117 +H HI++ + V + MV EY+ G+L ++ HG ++ A Sbjct: 95 QHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQL 154 Query: 118 -RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS 176 + Q+ + + Y VHRDL N L+ + KI DFG+S + ++ R + Sbjct: 155 LAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRT 214 Query: 177 P---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPF----DDEHVPTLFKKIRG 228 + PE I R + E D+WS GV+L+ + G P+ + E + + +G Sbjct: 215 MLPIRWMPPESILYRKFT-TESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI---TQG 270 Query: 229 GVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH-EWFKQDLPSYL 276 P V ++ Q +P +R +IKD+ + Q P YL Sbjct: 271 RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYL 319 >4F0G-A nrPDB Length = 287 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 98/208 (47%), Gaps = 17/208 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKIL----NRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 +G G FG V G VA+K L + + ++ + +RE+ + HP+I+ Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-RLFQQILSAVDYCHRHM-- 134 KLY ++ P MVME+V G+L+ + + + RL I ++Y Sbjct: 87 KLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQNQNPP 144 Query: 135 VVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 +VHRDL+ N+ L +A + AK+ADFGLS + G+ + APE I Sbjct: 145 IVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS--VSGLLGNFQWMAPETIGAEE 202 Query: 190 YAGPE-VDIWSCGVILYALLCGTLPFDD 216 + E D +S +ILY +L G PFD+ Sbjct: 203 ESYTEKADTYSFAMILYTILTGEGPFDE 230 >5AP3-A nrPDB Length = 313 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 25/247 (10%) Query: 43 AVKILNRQKIRSLDVVGKIKREIQNL-KLFRHP-HIIKLYQVISTPTDFFMVMEYVSGGE 100 A+K +N ++ + + + EI L KL +H II+LY T +MVME + Sbjct: 56 AIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNID 113 Query: 101 LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160 L ++ K ++ E + ++ +L AV H+H +VH DLKP N L+ M K+ DFG+ Sbjct: 114 LNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LKLIDFGI 172 Query: 161 SNMM---SDGEFLRTSCGSPNYAAPEVI----SGR------LYAGPEVDIWSCGVILYAL 207 +N M + + G+ NY PE I S R P+ D+WS G ILY + Sbjct: 173 ANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM 232 Query: 208 LCGTLPFDDEHVPTLFKKIRGGV-----FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G PF + + K+ + P+ + + +L L+ DP +R +I ++ Sbjct: 233 TYGKTPF--QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 290 Query: 263 REHEWFK 269 H + + Sbjct: 291 LAHPYVQ 297 >3BBT-B nrPDB Length = 328 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 81/315 (25%), Positives = 136/315 (43%), Gaps = 34/315 (10%) Query: 21 TLGVGTFGKVKIG----EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 LG G FG V G E + VA+KILN +V + E + HPH+ Sbjct: 22 VLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEALIMASMDHPHL 79 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ---QILSAVDYCHRH 133 ++L V +PT +V + + G L +Y+ +H + + ++ L QI + Y Sbjct: 80 VRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHK--DNIGSQLLLNWCVQIAKGMMYLEER 136 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLY 190 +VHRDL NVL+ + + KI DFGL+ ++ E + G + A E I R + Sbjct: 137 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF 196 Query: 191 AGPEVDIWSCGVILYALLC-GTLPFD---DEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 + D+WS GV ++ L+ G P+D +P L +K G P V +++ Sbjct: 197 TH-QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEK--GERLPQPPICTIDVYMVMV 253 Query: 247 HMLQVDPLKRATIKDI-REHEWFKQDLPSYLF-----------PEDPSYDANVIDDEAVK 294 +D R K++ E +D YL P D + N++D+E ++ Sbjct: 254 KCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLE 313 Query: 295 EVCEKFECTESEVMN 309 ++ + E + N Sbjct: 314 DMMDAEEYLVPQAFN 328 >1JPA-A nrPDB Length = 312 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 101/210 (48%), Gaps = 20/210 (9%) Query: 21 TLGVGTFGKVKIGEHQLTGHK---VAVKILNR---QKIRSLDVVGKIKREIQNLKLFRHP 74 +G G FG+V G +L G + VA+K L +K R E + F HP Sbjct: 40 VIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRR-----DFLSEASIMGQFDHP 94 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRH 133 ++I L V++ T ++ E++ G L ++ ++ G+ ++ + + I + + Y Sbjct: 95 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM 154 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN------YAAPEVISG 187 VHRDL N+L+++++ K++DFGLS + D T + + APE I Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 188 RLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 R + D+WS G++++ ++ G P+ D Sbjct: 215 RKFTSAS-DVWSYGIVMWEVMSYGERPYWD 243 >3E3P-A nrPDB Length = 360 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 105/217 (48%), Gaps = 23/217 (10%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNL 68 R ++ + + G GTFG V++G+ + TG VA+K ++ + R+ ++ + +Q+L Sbjct: 19 RKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNREL-----QIMQDL 73 Query: 69 KLFRHPHIIKLYQVIST-----PTDFFM--VMEYVSGGELFDYICKHGRVEEMEA----- 116 + HP+I++L T D ++ VMEYV + C++ ++ Sbjct: 74 AVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP--DTLHRCCRNYYRRQVAPPPILI 131 Query: 117 RRLFQQILSAVDYCH--RHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTS 173 + Q++ ++ H V HRD+KP NVL++ A K+ DFG + +S E Sbjct: 132 KVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAY 191 Query: 174 CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG 210 S Y APE+I G + VDIWS G I ++ G Sbjct: 192 ICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLG 228 >3UIM-A nrPDB Length = 326 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 101/208 (48%), Gaps = 19/208 (9%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G FGKV G G VAVK L ++ + ++ + + E++ + + H ++++L Sbjct: 36 NILGRGGFGKVYKG-RLADGTLVAVKRLKEERTQGGEL--QFQTEVEMISMAVHRNLLRL 92 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM------EARRLFQQILSAVDYCHRH 133 TPT+ +V Y++ G + C R E + +R+ + Y H H Sbjct: 93 RGFCMTPTERLLVYPYMANGSVAS--CLRERPESQPPLDWPKRQRIALGSARGLAYLHDH 150 Query: 134 M---VVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSPNYAAPEVIS-G 187 ++HRD+K N+LLD A + DFGL+ +M D G+ + APE +S G Sbjct: 151 CDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTG 210 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFD 215 + + + D++ GV+L L+ G FD Sbjct: 211 K--SSEKTDVFGYGVMLLELITGQRAFD 236 >2PSQ-A nrPDB Length = 370 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/241 (26%), Positives = 110/241 (45%), Gaps = 31/241 (12%) Query: 17 VLGDTLGVGTFGKVKIGE-------HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 LG LG G FG+V + E VAVK+L + + E++ +K Sbjct: 84 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK--DLSDLVSEMEMMK 141 Query: 70 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-----------GRV--EEME 115 + +H +II L + ++++EY S G L +Y+ RV E+M Sbjct: 142 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 201 Query: 116 ARRLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 172 + L Q+ ++Y +HRDL NVL+ + KIADFGL+ +++ ++ + Sbjct: 202 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKK 261 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG 228 + + APE + R+Y + D+WS GV+++ + G P+ V LFK ++ Sbjct: 262 TTNGRLPVKWMAPEALFDRVYTH-QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 320 Query: 229 G 229 G Sbjct: 321 G 321 >3N9X-A nrPDB Length = 432 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 102/223 (45%), Gaps = 32/223 (14%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y++ +G G++G V + + T VA+K +NR L +I REI L + Sbjct: 27 NYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRM-FEDLIDCKRILREITILNRLKSD 85 Query: 75 HIIKLYQVISTPTDF------FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +II+LY +I P D ++V+E ++ +L + E + + +L + Sbjct: 86 YIIRLYDLI-IPDDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGL---------SNMMSDGE----------- 168 + H ++HRDLKP N LL+ + K+ DFGL +N+++D E Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 169 ---FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL 208 L + + Y APE+I + +DIWS G I LL Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >2JD5-A nrPDB Length = 373 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 87/328 (26%), Positives = 134/328 (40%), Gaps = 70/328 (21%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK-----REIQ 66 K Y+L LG G F V + + + VA+KI+ K+ + +IK + Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDAD 76 Query: 67 NLK--LFRHPHIIKLYQVIS--TPTDFFMVMEY-VSGGELFDYICK--HGRVEEMEARRL 119 N K HI+KL + P +VM + V G L I K H + + +++ Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQI 136 Query: 120 FQQILSAVDYCHRHM-VVHRDLKPENVLLDA------HMNAKIADFGLSNMMSDGEFLRT 172 +Q+L +DY HR ++H D+KPENVL++ + KIAD G N E Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG--NACWYDEHYTN 194 Query: 173 SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----------DDEHVPTL 222 S + Y +PEV+ G + G DIWS +++ L+ G F DD+H+ + Sbjct: 195 SIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQI 253 Query: 223 FK--------KIRGG----VFYIPEYLNRSVATL-------------------------- 244 + +R G F+ L R+++ L Sbjct: 254 IELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDF 313 Query: 245 LMHMLQVDPLKRATIKDIREHEWFKQDL 272 L MLQ+DP KRA + H W K L Sbjct: 314 LSPMLQLDPRKRADAGGLVNHPWLKDTL 341 >2WTK-B nrPDB Length = 373 Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 108/233 (46%), Gaps = 19/233 (8%) Query: 14 GHYVLGDTLGVG--TFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 G Y L +G G V + ++ TG V V+ +N + S ++V ++ E+ KLF Sbjct: 9 GCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQGELHVSKLF 67 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVDY 129 HP+I+ + ++V +++ G D IC H + E+ + Q +L A+DY Sbjct: 68 NHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY 127 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYA------ 180 H VHR +K ++L+ ++ K+ GL +M+S G+ R P Y+ Sbjct: 128 IHHMGYVHRSVKASHILIS--VDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 181 -APEVISGRLYA-GPEVDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGV 230 +PEV+ L + DI+S G+ L G +PF D L +K+ G V Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTV 238 >5EG3-A nrPDB Length = 334 Score = 74.7 bits (182), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 64/241 (26%), Positives = 109/241 (45%), Gaps = 31/241 (12%) Query: 17 VLGDTLGVGTFGKVKIGE-------HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 LG LG G FG+V + E VAVK+L + + E++ +K Sbjct: 38 TLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK--DLSDLVSEMEMMK 95 Query: 70 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-----------GRV--EEME 115 + +H +II L + ++++ Y S G L +Y+ RV E+M Sbjct: 96 MIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMT 155 Query: 116 ARRLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 172 + L Q+ ++Y +HRDL NVL+ + KIADFGL+ +++ +F + Sbjct: 156 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKE 215 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG 228 + + APE + R+Y + D+WS GV+++ + G P+ V LFK ++ Sbjct: 216 TTNGRLPVKWMAPEALFDRVYTH-QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 274 Query: 229 G 229 G Sbjct: 275 G 275 >5XVU-A nrPDB Length = 332 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 43/145 (29%), Positives = 72/145 (49%), Gaps = 8/145 (5%) Query: 74 PHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+IIKL ++ P ++ EY++ D+ + + + + R QIL A+DYCH Sbjct: 86 PNIIKLLDIVKDPVTKTPSLIFEYINN---IDFKTLYPKFTDKDIRYYIYQILKALDYCH 142 Query: 132 RHMVVHRDLKPENVLLDAHMNAKI--ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 ++HRD+KP N+++D H N +I +GL+ G+ S Y PE++ Sbjct: 143 SQGIMHRDVKPHNIMID-HENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQ 201 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF 214 +DIWS G +L ++ PF Sbjct: 202 LYDYSLDIWSLGCMLAGMIFKKEPF 226 >3FI2-A nrPDB Length = 353 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 88/340 (25%), Positives = 132/340 (38%), Gaps = 70/340 (20%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 32 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 90 Query: 82 VISTPT-------DFFMVMEYVSGGELFDYICKHGRVEEMEARR--LFQQILSAVDYCHR 132 V TP D ++VME + +C+ ++E R L Q+L + + H Sbjct: 91 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 144 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 145 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK- 203 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEH---------------VPTLFKK----IRGGVFYI 233 VDIWS G I+ ++ + F P KK +R V Sbjct: 204 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 263 Query: 234 PEYL-------------------NRSVAT----LLMHMLQVDPLKRATIKDIREHEWFKQ 270 P+Y N+ A+ LL ML +DP KR ++ D +H + Sbjct: 264 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-- 321 Query: 271 DLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 + Y DE + E E EVMNS Sbjct: 322 ---------NVWYXXXXXXDEREHTIEEWKELIYKEVMNS 352 >5IKW-A nrPDB Length = 310 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 81/269 (30%), Positives = 128/269 (47%), Gaps = 40/269 (14%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRHPHI 76 L ++L G F V + G + A+K + + L+V KREI +K L H +I Sbjct: 18 LEESLAEGGFSTVFLVRTH-GGIRCALKRMYVNNMPDLNVC---KREITIMKELSGHKNI 73 Query: 77 IK-LYQVISTPTD----FFMVMEYVSGGELFDYICKHGRV--EEMEARRLFQQILSAVDY 129 + L +++ +D ++MEY G++ + + K + E E ++F AV Sbjct: 74 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVAR 133 Query: 130 CH--RHMVVHRDLKPENVLLDAHMNAKIADFGLS-----NMMSDG------EFLRTSCGS 176 H + ++HRDLK EN+LL+ N + DFG + N DG E + + + Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT--T 191 Query: 177 PNYAAPEVISGRLYAGPEV----DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY 232 +Y APE+I+ LY G + DIW+ G +LY L TLPF + V I G F Sbjct: 192 LSYRAPEMIN--LYGGKPITTKADIWALGCLLYKLCFFTLPFGESQV-----AICDGNFT 244 Query: 233 IPEY--LNRSVATLLMHMLQVDPLKRATI 259 IP+ +R++ L+ ML+ DP R I Sbjct: 245 IPDNSRYSRNIHCLIRFMLEPDPEHRPDI 273 >3VN9-A nrPDB Length = 340 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 98/210 (46%), Gaps = 16/210 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH----PHII 77 LG G +G V+ H +G +AVK +IR+ + KR + +L + P + Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 Query: 78 KLYQVISTPTDFFMVMEYV--SGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 134 Y + D ++ ME + S + + + G+ + E ++ I+ A+++ H + Sbjct: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Query: 135 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL-YAG 192 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L G Sbjct: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 Query: 193 PEV--DIWSCGVILYALLCGTLPFDDEHVP 220 V DIWS G+ + L P+D P Sbjct: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTP 263 >5L6P-A nrPDB Length = 298 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 102/215 (47%), Gaps = 28/215 (13%) Query: 20 DTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQN-------LK 69 + +G G FG+V G + G + VA+K L VG +R+ ++ + Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLK---------VGYTERQRRDFLSEASIMG 75 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVD 128 F HP+II+L V++ ++ E++ L ++ G+ ++ + + I + + Sbjct: 76 QFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMK 135 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN------YAAP 182 Y VHRDL N+L+++++ K++DFGLS + D T S + AP Sbjct: 136 YLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAP 195 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 E I+ R + D+WS G++++ ++ G P+ D Sbjct: 196 EAIAYRKFTSAS-DVWSYGIVMWEVMSYGERPYWD 229 >6O6Q-A nrPDB Length = 335 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 99/205 (48%), Gaps = 15/205 (7%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LFRH 73 +Y + LG G + +V +G KV +K+L K + KIKREI LK L Sbjct: 42 NYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRK------KIKREISILKNLVDG 95 Query: 74 PHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+II + V+ P ++ E+++ D+ + + + R ++L A+DY H Sbjct: 96 PNIIAMLDVVREPQSKTPGLIFEHINN---IDFRSLYPTFTDYDIRFYMYELLKALDYSH 152 Query: 132 RHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPE-VISGRL 189 ++HRD+KP NV++D ++ D+GL+ G S + PE ++ RL Sbjct: 153 SMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRL 212 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF 214 Y +D+WS G +L +++ PF Sbjct: 213 Y-DYSLDMWSFGCMLASMVFMKEPF 236 >4E7W-A nrPDB Length = 394 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 101/213 (47%), Gaps = 20/213 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y +G G+FG V + +VA+K +L ++ ++ RE+Q +++ +HP Sbjct: 42 YTNCKVIGNGSFGVV-FQAKLVESDEVAIKKVLQDKRFKN--------RELQIMRIVKHP 92 Query: 75 HIIKLYQVISTPTD------FFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQ-QILS 125 +++ L + D +V+EYV + K + M +L+ Q+L Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 ++ Y H + HRD+KP+N+LLD K+ DFG + ++ GE + S Y APE+ Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPEL 212 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDE 217 I G +DIWS G ++ L+ G F E Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGE 245 >3BEA-A nrPDB Length = 333 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 122/271 (45%), Gaps = 29/271 (10%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKREIQNLK-LF 71 G TLG G FGKV G KVAVK+L + D + E++ + L Sbjct: 50 FGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML--KSTAHADEKEALMSELKIMSHLG 107 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE-----------MEARRLF 120 +H +I+ L + ++ EY G+L +++ + RV E + R L Sbjct: 108 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLL 167 Query: 121 Q---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFL-RTSCG 175 Q+ + + +HRD+ NVLL AKI DFGL+ ++M+D ++ + + Sbjct: 168 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 227 Query: 176 SP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGGVF 231 P + APE I +Y + D+WS G++L+ + G P+ V + F K+ G Sbjct: 228 LPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 286 Query: 232 YIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 P + +++ +++ ++P R T + I Sbjct: 287 AQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >4M66-A nrPDB Length = 325 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 102/209 (48%), Gaps = 34/209 (16%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G FG V H+ H VAVKI+N +KI E++ + R+ +++ L Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIVNSKKI---------SWEVKAMVNLRNENVLLLLG 78 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEM---EARR-------LFQQILSAVDYCH 131 V + ++VSG L ++G + + EA R L Q+++ + Y H Sbjct: 79 VTED-----LQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLH 133 Query: 132 R--HMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-------SDGEFLRTSCGSPNYAAP 182 ++HRDLKP N+LLD ++AK+ADFGLS G R S G+ Y P Sbjct: 134 SLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDP 193 Query: 183 EVI-SGRLYAGPEVDIWSCGVILYALLCG 210 E++ L A D++S G++++A+L G Sbjct: 194 ELLFKVNLKASKASDVYSFGILVWAVLAG 222 >5TOS-A nrPDB Length = 395 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 68/215 (31%), Positives = 104/215 (48%), Gaps = 28/215 (13%) Query: 22 LGVGTFGKVKIG---EHQLT------GHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 +G G FG V G E LT G +AVK LN++ + + EI L Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEINYLGQLS 129 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD---- 128 HP+++KL +V E++ G L +++ + G + F ++ A+D Sbjct: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY--FKPLPWFLRVNVALDAAKG 187 Query: 129 --YCHRH--MVVHRDLKPENVLLDAHMNAKIADFGLS--NMMSDGEFLRTSC-GSPNYAA 181 + H V++RD+K N+LLDA NAK++DFGL+ M D ++ T G+ YAA Sbjct: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 Query: 182 PEVI-SGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 PE + SG L A D++S GV+L +L G D Sbjct: 248 PEYMSSGHLNA--RSDVYSFGVLLLEILSGKRALD 280 >5ZTN-A nrPDB Length = 429 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 64/216 (29%), Positives = 110/216 (50%), Gaps = 24/216 (11%) Query: 16 YVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKIL------NRQKIRSLDVVGKIKREIQNL 68 Y + +G G+FG+V K +H++ H VA+K++ +RQ + ++ ++++ ++ Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQH-VALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME---ARRLFQQILS 125 + ++I + + + M E +S L++ I K + + R+ IL Sbjct: 158 TM----NVIHMLENFTFRNHICMTFELLSM-NLYELI-KKNKFQGFSLPLVRKFAHSILQ 211 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 +D H++ ++H DLKPEN+LL + K+ DFG S + + + T S Y APE Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYTYIQSRFYRAPE 269 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCG--TLPFDDE 217 VI G Y P +D+WS G IL LL G LP +DE Sbjct: 270 VILGARYGMP-IDMWSLGCILAELLTGYPLLPGEDE 304 >4HZS-A nrPDB Length = 341 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 71/258 (27%), Positives = 107/258 (41%), Gaps = 13/258 (5%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 L + LG G+FG V+ GE K VAVK L + + + RE+ + H Sbjct: 16 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHR 75 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRH 133 ++I+LY V+ TP MV E G L D + KH G R Q+ + Y Sbjct: 76 NLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESK 134 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSP-NYAAPEVISGRL 189 +HRDL N+LL KI DFGL + D ++ P + APE + R Sbjct: 135 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRT 194 Query: 190 YAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVATLLM 246 ++ D W GV L+ + G P+ + + KI G PE + + +++ Sbjct: 195 FSHAS-DTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMV 253 Query: 247 HMLQVDPLKRATIKDIRE 264 P R T +R+ Sbjct: 254 QCWAHKPEDRPTFVALRD 271 >3FME-A nrPDB Length = 290 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 103/217 (47%), Gaps = 18/217 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH----PHII 77 LG G +G V+ H +G +AVK +IR+ + KR + +L + P + Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 69 Query: 78 KLYQVISTPTDFFMVMEYV--SGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 134 Y + D ++ ME + S + + + G+ + E ++ I+ A+++ H + Sbjct: 70 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 129 Query: 135 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL-YAG 192 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L G Sbjct: 130 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQKG 189 Query: 193 PEV--DIWSCGVILYALLCGTLPFDDEHVPTLFKKIR 227 V DIWS G+ + L P+D P F++++ Sbjct: 190 YSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLK 224 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 23/115 (20%) Query: 319 QLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPH--PERMPPLIAD 376 +L+V + + + ++N + + SG +DD A I G KP+ PER+ P Sbjct: 128 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINP---- 183 Query: 377 SPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSK-----PYDIMAEVYRAMKQL 426 LN K +VK W LGI PYD ++ +KQ+ Sbjct: 184 ---------ELNQ---KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 226 >5X8I-B nrPDB Length = 346 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 88/343 (25%), Positives = 145/343 (42%), Gaps = 102/343 (29%) Query: 9 GRVKIGHYVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKILN---------RQKIRSLDVV 58 G V Y + DTLG G FGKV + +H+ G VAVKI+ R +I+ L+ + Sbjct: 8 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL 67 Query: 59 GKIK-----REIQNLKLFRH-PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG--- 109 R +Q L+ F H HI +++++ T +D+I ++G Sbjct: 68 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLST--------------YDFIKENGFLP 113 Query: 110 -RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL------DAHM----------- 151 R++ + R++ QI +V++ H + + H DLKPEN+L +A+ Sbjct: 114 FRLDHI--RKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLI 171 Query: 152 --NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVIL--YAL 207 + K+ DFG + D E T + +Y APEVI ++ P D+WS G IL Y L Sbjct: 172 NPDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQP-CDVWSIGCILIEYYL 228 Query: 208 LCGTLPFDD--EHVPT-----------LFKKIRGGVFY------------IPEYLNRS-- 240 P D EH+ + +K R ++ Y++R+ Sbjct: 229 GFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACK 288 Query: 241 ---------------VATLLMHMLQVDPLKRATIKDIREHEWF 268 + L+ ML+ DP KR T+++ +H +F Sbjct: 289 PLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >3KRL-A nrPDB Length = 335 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 69/273 (25%), Positives = 123/273 (45%), Gaps = 31/273 (11%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKREIQNLK-LF 71 G TLG G FGKV G KVAVK+L + D + E++ + L Sbjct: 50 FGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML--KSTAHADEKEALMSELKIMSHLG 107 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-------------HGRVEEMEARR 118 +H +I+ L + ++ EY G+L +++ + H E++ +R Sbjct: 108 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRD 167 Query: 119 LFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFL-RTS 173 L Q+ + + +HRD+ NVLL AKI DFGL+ ++M+D ++ + + Sbjct: 168 LLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGN 227 Query: 174 CGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGG 229 P + APE I +Y + D+WS G++L+ + G P+ V + F K+ G Sbjct: 228 ARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGY 286 Query: 230 VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 P + +++ +++ ++P R T + I Sbjct: 287 QMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >1U54-B nrPDB Length = 291 Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 71/258 (27%), Positives = 107/258 (41%), Gaps = 13/258 (5%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 L + LG G+FG V+ GE K VAVK L + + + RE+ + H Sbjct: 22 LLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHR 81 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRH 133 ++I+LY V+ TP MV E G L D + KH G R Q+ + Y Sbjct: 82 NLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESK 140 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSP-NYAAPEVISGRL 189 +HRDL N+LL KI DFGL + D ++ P + APE + R Sbjct: 141 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRT 200 Query: 190 YAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVATLLM 246 ++ D W GV L+ + G P+ + + KI G PE + + +++ Sbjct: 201 FSHAS-DTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMV 259 Query: 247 HMLQVDPLKRATIKDIRE 264 P R T +R+ Sbjct: 260 QCWAHKPEDRPTFVALRD 277 >5MJB-A nrPDB Length = 305 Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 105/225 (46%), Gaps = 30/225 (13%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILN--------RQKIRSLDVVG 59 + + + + +G G FG+V G +L G + VA+K L R + ++G Sbjct: 23 IDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMG 82 Query: 60 KIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARR 118 + F H +II+L V++ ++ E++ L ++ ++ G+ ++ Sbjct: 83 Q----------FDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVG 132 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS-- 176 + + I + + Y VHRDL N+L+++++ K++DFGLS + D T S Sbjct: 133 MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLG 192 Query: 177 ----PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 + APE I+ R + D+WS G++++ ++ G P+ D Sbjct: 193 GKIPVRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSFGERPYWD 236 >4XCU-A nrPDB Length = 300 Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 115/268 (42%), Gaps = 23/268 (8%) Query: 17 VLGDTLGVGTFGKVKIGE-------HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 VLG LG G FG+V E VAVK+L S + + E++ +K Sbjct: 20 VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLADLVSEMEVMK 77 Query: 70 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------- 121 L RH +II L V + ++++E + G L +++ E F Sbjct: 78 LIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAY 137 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCG--SPN 178 Q+ + Y +HRDL NVL+ KIADFGL+ + ++ +TS G Sbjct: 138 QVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVK 197 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEY 236 + APE + R+Y + D+WS G++L+ + G P+ V LF +R G P + Sbjct: 198 WMAPEALFDRVYTH-QSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH 256 Query: 237 LNRSVATLLMHMLQVDPLKRATIKDIRE 264 + L+ P +R T K + E Sbjct: 257 CPPELYGLMRECWHAAPSQRPTFKQLVE 284 >4LFI-A nrPDB Length = 374 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 8/146 (5%) Query: 73 HPHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 H +II L+ +I P +V EYV D+ + ++ ++E R ++L A+DYC Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 188 Query: 131 HRHMVVHRDLKPENVLLDAHMNAK--IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 H ++HRD+KP NV++D H N K + D+GL+ S + PE++ Sbjct: 189 HSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 247 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPF 214 +D+WS G +L +++ PF Sbjct: 248 RMYDYSLDLWSFGTMLASMIFKREPF 273 >4G3E-A nrPDB Length = 352 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 112/255 (43%), Gaps = 25/255 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G+FG+V + + TG + AVK + + R ++V P I+ LY Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACAG--------LSSPRIVPLYG 133 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 + + ME + GG L I + G + E A Q L ++Y H ++H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 142 PENVLLDAHMN-AKIADF---------GLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +NVLL + + A + DF GL + G+++ G+ + APEV+ G+ Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIP---GTETHMAPEVVMGK-PC 249 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS---VATLLMHM 248 +VDIWS ++ +L G P+ L KI I E A + Sbjct: 250 DAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEG 309 Query: 249 LQVDPLKRATIKDIR 263 L+ +P+ RA+ ++R Sbjct: 310 LRKEPVHRASAMELR 324 >5U6B-A nrPDB Length = 307 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 66/268 (24%), Positives = 121/268 (45%), Gaps = 23/268 (8%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGH--KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 LG TLG G FG V G+ KVAVK + + I + + E +K F HP Sbjct: 26 ALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELEDFLSEAVCMKEFDHP 84 Query: 75 HIIKLYQVI---STPTDF---FMVMEYVSGGELFDYICKHGRVEEMEAR-------RLFQ 121 ++++L V S F +++ ++ G+L ++ + R+ + + Sbjct: 85 NVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLL-YSRLGDQPVYLPTQMLVKFMA 143 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSP-N 178 I S ++Y +HRDL N +L+ +M+ +ADFGLS + +G++ R P Sbjct: 144 DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK 203 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR-GGVFYIPEY 236 + A E ++ R+Y + D+WS GV ++ + G P+ ++ +R G P Sbjct: 204 WIAIESLADRVYTS-KSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPAD 262 Query: 237 LNRSVATLLMHMLQVDPLKRATIKDIRE 264 + L+ +++P R + ++RE Sbjct: 263 CLDGLYALMSRCWELNPQDRPSFTELRE 290 >5AIR-A nrPDB Length = 430 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 98/208 (47%), Gaps = 23/208 (11%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y +G G+FG V + +G VA+K +L ++ ++ RE+Q ++ H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 117 Query: 75 HIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKH-GRVEE----MEARRLFQQI 123 +I++L + + +V++YV E + +H R ++ + + Q+ Sbjct: 118 NIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQL 175 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 ++ Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y AP Sbjct: 176 FRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 235 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCG 210 E+I G +D+WS G +L LL G Sbjct: 236 ELIFGATDYTSSIDVWSAGCVLAELLLG 263 >2OGV-A nrPDB Length = 317 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/267 (25%), Positives = 121/267 (45%), Gaps = 25/267 (9%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKREIQNLK-LF 71 G TLG G FGKV G KVAVK+L + D + E++ + L Sbjct: 42 FGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML--KSTAHADEKEALMSELKIMSHLG 99 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE-------EMEARRLFQ--- 121 +H +I+ L + ++ EY G+L +++ + + +E R L Sbjct: 100 QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSS 159 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFL-RTSCGSP-N 178 Q+ + + +HRD+ NVLL AKI DFGL+ ++M+D ++ + + P Sbjct: 160 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 219 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGGVFYIPE 235 + APE I +Y + D+WS G++L+ + G P+ V + F K+ G P Sbjct: 220 WMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPA 278 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDI 262 + +++ +++ ++P R T + I Sbjct: 279 FAPKNIYSIMQACWALEPTHRPTFQQI 305 >5WNL-A nrPDB Length = 342 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 127/275 (46%), Gaps = 41/275 (14%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVK------ILNRQKIRSLDVVGKIKREIQN 67 G + + +G G FG+V H +A+K + +R+++ L+ E + Sbjct: 20 GEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLE-------EAKK 72 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA- 126 +++ + +I+ +Y + P +VMEY+ G L + ++ R + + + Sbjct: 73 MEMAKFRYILPVYGICQEPVG--LVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMN 130 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS--NMMS-------DGEFLRTSCGSP 177 +C ++H +LKP N+LLDAH + KI+DFGL+ N MS DG F G+ Sbjct: 131 FLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLF-----GTI 185 Query: 178 NYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH--VPTLFKKIRGGVFYI 233 Y PE I RL+ D++S ++++ +L PF DE + + K ++G + Sbjct: 186 AYLPPERIREKSRLFDTKH-DVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPEL 244 Query: 234 PEYLN---RSVATLLMHM---LQVDPLKRATIKDI 262 P R+ A+L+ M DP R T ++I Sbjct: 245 PPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >3PLS-A nrPDB Length = 298 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/255 (24%), Positives = 110/255 (43%), Gaps = 21/255 (8%) Query: 21 TLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 +G G FG V GE+ +++ I + +I + V RE ++ HP+++ L Sbjct: 28 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLAL 87 Query: 80 YQVISTPTDF-FMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHRHMVVH 137 ++ P +++ Y+ G+L +I R ++ F Q+ ++Y VH Sbjct: 88 IGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVH 147 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-----RTSCGSPNYAAPEVISGRLYAG 192 RDL N +LD K+ADFGL+ + D E+ R + + A E + + Sbjct: 148 RDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRFTT 207 Query: 193 PEVDIWSCGVILYALLCGTL-------PFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 + D+WS GV+L+ LL PFD H +++ PEY S+ ++ Sbjct: 208 -KSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQ-----PEYCPDSLYQVM 261 Query: 246 MHMLQVDPLKRATIK 260 + DP R T + Sbjct: 262 QQCWEADPAVRPTFR 276 >6EII-A nrPDB Length = 352 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 72/144 (50%), Gaps = 6/144 (4%) Query: 74 PHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+II L ++ P +V E+V+ D+ + + + + R +IL A+DYCH Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCH 171 Query: 132 RHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 172 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 231 Query: 191 AGPEVDIWSCGVILYALLCGTLPF 214 +D+WS G +L +++ PF Sbjct: 232 YDYSLDMWSLGCMLASMIFRKEPF 255 >6HV0-A nrPDB Length = 416 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 73/271 (26%), Positives = 118/271 (43%), Gaps = 27/271 (9%) Query: 24 VGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK---------IKREIQNLKLF-RH 73 V GK+ + GH I+ R + DV K RE+Q L+ H Sbjct: 2 VVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEH 61 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE-EMEARRLFQQILSAVDYCHR 132 P++I+ Y F + + L +Y+ + +E L QQ S + + H Sbjct: 62 PNVIR-YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHS 120 Query: 133 HMVVHRDLKPENVLL---DAH--MNAKIADFGLSNMMSDGE--FLRTSC--GSPNYAAPE 183 +VHRDLKP N+L+ +AH + A I+DFGL ++ G F R S G+ + APE Sbjct: 121 LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 180 Query: 184 VISGRLYAGP--EVDIWSCGVILYALLC-GTLPFD---DEHVPTLFKKIRGGVFYIPEYL 237 ++S P VDI+S G + Y ++ G+ PF L + ++ Sbjct: 181 MLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHE 240 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + L+ M+ +DP KR + K + +H +F Sbjct: 241 DVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >6FYV-A nrPDB Length = 337 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/241 (26%), Positives = 106/241 (43%), Gaps = 50/241 (20%) Query: 9 GRVKIGHYVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKILN---------RQKIRSLDVV 58 G V Y + DTLG G FGKV + +H + G VAVKI+ R +I+ L+ + Sbjct: 9 GDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHL 68 Query: 59 GK-----IKREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE 112 + R +Q L+ F H H+ +++++ T +++ + H Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLST-----YDFIKENSFLPFQIDH---- 119 Query: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL---------DAHM----------NA 153 R++ QI ++++ H + + H DLKPEN+L ++ M + Sbjct: 120 ---IRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDI 176 Query: 154 KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP 213 K+ DFG + D E T + +Y APEVI ++ P D+WS G IL G Sbjct: 177 KVVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQP-CDVWSIGCILIEYYLGFTV 233 Query: 214 F 214 F Sbjct: 234 F 234 >5GRN-A nrPDB Length = 356 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 123/289 (42%), Gaps = 47/289 (16%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 VLG LG G FGKV G KVAVK+L + RS + + + LK+ Sbjct: 49 VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARS----SEKQALMSELKIM 103 Query: 72 RH--PH--IIKLYQVISTPTDFFMVMEYVSGGELFDYICKH---------GRVEEMEARR 118 H PH I+ L + +++ EY G+L +Y+ K+ + + E + Sbjct: 104 THLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKN 163 Query: 119 LFQ-----------------QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS 161 L Q+ +++ VHRDL NVLL KI DFGL+ Sbjct: 164 LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA 223 Query: 162 -NMMSDGEFL-RTSCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDE 217 ++M D ++ + S P + APE I LY D+WS G++L+ + G P+ Sbjct: 224 RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLS-DVWSYGILLWEIFSLGGTPYPGM 282 Query: 218 HV-PTLFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 V T + KI+ G P++ V +++ +P KR + + E Sbjct: 283 MVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE 331 >4MD7-E nrPDB Length = 391 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 72/144 (50%), Gaps = 6/144 (4%) Query: 74 PHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+II L ++ P +V E+V+ D+ + + + + R +IL A+DYCH Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNT---DFKQLYQTLTDYDIRFYMYEILKALDYCH 148 Query: 132 RHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 Query: 191 AGPEVDIWSCGVILYALLCGTLPF 214 +D+WS G +L +++ PF Sbjct: 209 YDYSLDMWSLGCMLASMIFRKEPF 232 >1FVR-A nrPDB Length = 327 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 68/264 (25%), Positives = 115/264 (43%), Gaps = 24/264 (9%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KLFRHPHIIK 78 D +G G FG+V + G ++ I ++ S D E++ L KL HP+II Sbjct: 31 DVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIIN 90 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF---------QQIL----- 124 L ++ +EY G L D++ K +E A + QQ+L Sbjct: 91 LLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAAD 150 Query: 125 --SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS--PNYA 180 +DY + +HRDL N+L+ + AKIADFGLS +++ + G + Sbjct: 151 VARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYVKKTMGRLPVRWM 208 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLN 238 A E ++ +Y D+WS GV+L+ ++ G P+ L++K+ +G P + Sbjct: 209 AIESLNYSVYT-TNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCD 267 Query: 239 RSVATLLMHMLQVDPLKRATIKDI 262 V L+ + P +R + I Sbjct: 268 DEVYDLMRQCWREKPYERPSFAQI 291 >2RIO-A nrPDB Length = 434 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 80/290 (27%), Positives = 128/290 (44%), Gaps = 56/290 (19%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR----HPHII 77 LG G+ G V + + G VAVK R I D+ + +KL HP++I Sbjct: 23 LGYGSSGTV-VFQGSFQGRPVAVK---RMLIDFCDIA------LMEIKLLTESDDHPNVI 72 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARR------LFQQILSAVDYC 130 + Y +T ++ +E + L D + K+ E ++ ++ L +QI S V + Sbjct: 73 RYYCSETTDRFLYIALE-LCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 131 HRHMVVHRDLKPENVLL--------DAHMNAK-----IADFGLSNMMSDGE-FLRTSCGS 176 H ++HRDLKP+N+L+ D A+ I+DFGL + G+ RT+ + Sbjct: 132 HSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 177 PN----YAAPEVI--SGRLYAGPE----VDIWSCGVILYALLC-GTLPFDDEHVPTLFKK 225 P+ + APE++ S L +DI+S G + Y +L G PF D++ Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE--SN 249 Query: 226 IRGGVFYIPEY-------LNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 I G+F + E L L+ M+ DPLKR T + H F Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >4K33-A nrPDB Length = 325 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 118/275 (42%), Gaps = 28/275 (10%) Query: 17 VLGDTLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRSLDVVGK----IKREIQNLKLF 71 LG LG G FG+V + E + + A + K+ D K + E++ +K+ Sbjct: 39 TLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 98 Query: 72 -RHPHIIKLYQVISTPTDFFMVMEYVSGGEL-----------FDYICKHGR--VEEMEAR 117 +H +II L + ++++EY + G L DY + E++ + Sbjct: 99 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFK 158 Query: 118 RLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 174 L Q+ ++Y +HRDL NVL+ KIADFGL+ + + ++ + + Sbjct: 159 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETT 218 Query: 175 GSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG- 229 + APE + R+Y + D+WS GV+L+ + G P+ V LFK ++ G Sbjct: 219 NGRLPVKWMAPEALFDRVYTH-QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH 277 Query: 230 VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 P + ++ P +R T K + E Sbjct: 278 RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 312 >3LMG-A nrPDB Length = 344 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 120/270 (44%), Gaps = 21/270 (7%) Query: 21 TLGVGTFGKVKIG----EHQLTGHKVAVKILNRQKIR-SLDVVGKIKREIQNLKLFRHPH 75 LG G FG V G E + V +K++ + R S V I +L H H Sbjct: 38 VLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLD---HAH 94 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRHM 134 I++L + + +V +Y+ G L D++ +H G + QI + Y H Sbjct: 95 IVRLLGLCPG-SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHG 153 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSP-NYAAPEVISGRLYA 191 +VHR+L NVLL + ++ADFG+++++ D + L + +P + A E I Y Sbjct: 154 MVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYT 213 Query: 192 GPEVDIWSCGVILYALLC-GTLPFDD---EHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + D+WS GV ++ L+ G P+ VP L +K G P+ V +++ Sbjct: 214 H-QSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEK--GERLAQPQICTIDVYMVMVK 270 Query: 248 MLQVDPLKRATIKDI-REHEWFKQDLPSYL 276 +D R T K++ E +D P YL Sbjct: 271 CWMIDENIRPTFKELANEFTRMARDPPRYL 300 >3ZZW-A nrPDB Length = 289 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 74/277 (26%), Positives = 116/277 (41%), Gaps = 45/277 (16%) Query: 20 DTLGVGTFGKVKIGEHQLTG-------HKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + LG FGKV G L G VA+K L + G ++ E ++ + R Sbjct: 15 EELGEDRFGKVYKG--HLFGPAPGEQTQAVAIKTLKDK------AEGPLREEFRHEAMLR 66 Query: 73 ----HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC---KHGRVEEMEARR------- 118 HP+++ L V++ M+ Y S G+L +++ H V + R Sbjct: 67 ARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALE 126 Query: 119 ------LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--- 169 L QI + ++Y H VVH+DL NVL+ +N KI+D GL + ++ Sbjct: 127 PPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKL 186 Query: 170 LRTSCGSPNYAAPEVISGRLYAGPEV--DIWSCGVILYALLC-GTLPFDDEHVPTLFKKI 226 L S + APE I +Y + DIWS GV+L+ + G P+ + + I Sbjct: 187 LGNSLLPIRWMAPEAI---MYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 Query: 227 RG-GVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 R V P+ V L++ P +R KDI Sbjct: 244 RNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5C26-A nrPDB Length = 299 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 95/199 (47%), Gaps = 8/199 (4%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKI-LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G FG VK G +Q+ V + + + + + ++ E ++ +P+I+++ Sbjct: 35 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 94 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + + + +VME G L Y+ ++ V++ L Q+ + Y VHRDL Sbjct: 95 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 153 Query: 141 KPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 NVLL AKI+DFGLS + +D + + + APE I+ ++ + D Sbjct: 154 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KSD 212 Query: 197 IWSCGVILY-ALLCGTLPF 214 +WS GV+++ A G P+ Sbjct: 213 VWSFGVLMWEAFSYGQKPY 231 >4FL3-A nrPDB Length = 635 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 95/199 (47%), Gaps = 8/199 (4%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKI-LNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G FG VK G +Q+ V + + + + + ++ E ++ +P+I+++ Sbjct: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + + + +VME G L Y+ ++ V++ L Q+ + Y VHRDL Sbjct: 437 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 Query: 141 KPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVD 196 NVLL AKI+DFGLS + +D + + + APE I+ ++ + D Sbjct: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KSD 554 Query: 197 IWSCGVILY-ALLCGTLPF 214 +WS GV+++ A G P+ Sbjct: 555 VWSFGVLMWEAFSYGQKPY 573 >5TE0-A nrPDB Length = 347 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 131/290 (45%), Gaps = 61/290 (21%) Query: 22 LGVGTFGKV-KIGEHQLT--------------------GHKVAVKILNRQKIRSLDVVGK 60 LG G G+V IG Q+T G K A+K + L V Sbjct: 5 LGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVC-- 62 Query: 61 IKREIQNLK-LFRHPHII-----KLYQVISTPT-DFFMVMEYVSGGELFDYICKHGRV-- 111 KREIQ ++ L H +I+ + V S + ++M++ GG++ + + + + Sbjct: 63 -KREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGF 121 Query: 112 EEMEARRLFQQILSAVDYCH--RHMVVHRDLKPENVLLDAHMNAKIADFG-----LSNMM 164 E E ++F AV H + ++HRDLK EN+LL + + DFG N Sbjct: 122 TENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ 181 Query: 165 SDG------EFLRTSCGSPNYAAPEVISGRLYAG----PEVDIWSCGVILYALLCGTLPF 214 ++G E + + + +Y APE+++ LY+G + DIW+ G +LY L TLPF Sbjct: 182 TEGVNAVEDEIKKYT--TLSYRAPEMVN--LYSGKIITTKADIWALGCLLYKLCYFTLPF 237 Query: 215 DDEHVPTLFKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDI 262 + V I G F IP+ ++ + L+ +ML+ DP KR I + Sbjct: 238 GESQV-----AICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >2QKW-B nrPDB Length = 321 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 62/199 (31%), Positives = 98/199 (49%), Gaps = 18/199 (9%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G FGKV G + G KVA+K R+ S + + + EI+ L RHPH++ L Sbjct: 47 IGHGVFGKVYKGVLR-DGAKVALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLIG 102 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSA---VDYCHRHMV 135 + ++ +Y+ G L ++ +G M + + + A + Y H + Sbjct: 103 FCDERNEMILIYKYMENGNLKRHL--YGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSC-GSPNYAAPE-VISGRLYA 191 +HRD+K N+LLD + KI DFG+S + D L T G+ Y PE I GRL Sbjct: 161 IHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL-- 218 Query: 192 GPEVDIWSCGVILYALLCG 210 + D++S GV+L+ +LC Sbjct: 219 TEKSDVYSFGVVLFEVLCA 237 >5VD3-A nrPDB Length = 311 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 109/246 (44%), Gaps = 13/246 (5%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G++G+V + G AVK D K+ + K+ +HP ++L Q Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQ 124 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 ++ E + G L + G + E + + L A+ + H +VH D+ Sbjct: 125 AWEEGGILYLQTE-LCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDV 183 Query: 141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 KP N+ L K+ DFGL + G P Y APE++ G G D++S Sbjct: 184 KPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSY--GTAADVFSL 241 Query: 201 GVILYALLCGT-LPFDDEHVPTLFKKIRGGVFYIPEY---LNRSVATLLMHMLQVDPLKR 256 G+ + + C LP E ++++R G + PE+ L+ + ++L+ ML+ DP R Sbjct: 242 GLTILEVACNMELPHGGEG----WQQLRQG-YLPPEFTAGLSSELRSVLVMMLEPDPKLR 296 Query: 257 ATIKDI 262 AT + + Sbjct: 297 ATAEAL 302 >3EB0-A nrPDB Length = 383 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 99/247 (40%), Gaps = 55/247 (22%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKIL---NRQKIRSLDVVGKIKREIQNLKLFR 72 Y LG TLG G+FG V +G + A+K + R K R LD+ +K+ Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDI----------MKVLD 58 Query: 73 HPHIIKLYQVISTPTD--------------------------------------FFMVME 94 H +IIKL T D ++ME Sbjct: 59 HVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIME 118 Query: 95 YVSGG--ELFDYICKHGRVEEMEARRLF-QQILSAVDYCHRHMVVHRDLKPENVLLDAHM 151 YV ++ + GR M ++ Q+ AV + H + HRD+KP+N+L+++ Sbjct: 119 YVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKD 178 Query: 152 NA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG 210 N K+ DFG + + E S Y APE++ G P +D+WS G + L+ G Sbjct: 179 NTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILG 238 Query: 211 TLPFDDE 217 F E Sbjct: 239 KPLFSGE 245 >4PL5-B nrPDB Length = 435 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 71/267 (26%), Positives = 116/267 (43%), Gaps = 27/267 (10%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK---------IKREIQNLKLF-RHPHII 77 GK+ + GH I+ + + DV K RE+Q L+ HP++I Sbjct: 25 GKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVI 84 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE-EMEARRLFQQILSAVDYCHRHMVV 136 + Y F + + L +Y+ + +E L Q S + + H +V Sbjct: 85 R-YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIV 143 Query: 137 HRDLKPENVLL---DAH--MNAKIADFGLSNMMSDGE--FLRTSC--GSPNYAAPEVISG 187 HRDLKP N+LL +AH + A I+DFGL ++ G F R S G+ + APE++S Sbjct: 144 HRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 203 Query: 188 RLYAGP--EVDIWSCGVILYALLC-GTLPFD---DEHVPTLFKKIRGGVFYIPEYLNRSV 241 P VDI+S G + Y ++ G PF L F+ ++ + Sbjct: 204 DCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHSDKHEDVIA 263 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF 268 L+ M+ +DP +R + K + +H +F Sbjct: 264 RELIEKMIAMDPQQRPSAKHVLKHPFF 290 >5GNK-A nrPDB Length = 297 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 98/204 (48%), Gaps = 13/204 (6%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQ--KIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G FG V G G KV + + ++ + S +I E + +PH+ + Sbjct: 26 VLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCR 85 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ---QILSAVDYCHRHMV 135 L + T T ++M+ + G L DY+ +H + + ++ L QI ++Y + Sbjct: 86 LLGICLTST-VQLIMQLMPFGCLLDYVREHK--DNIGSQYLLNWCVQIAKGMNYLEDRRL 142 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP-NYAAPEVISGRLYAG 192 VHRDL NVL+ + KI DFGL+ ++ + E+ P + A E I R+Y Sbjct: 143 VHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTH 202 Query: 193 PEVDIWSCGVILYALLC-GTLPFD 215 + D+WS GV ++ L+ G+ P+D Sbjct: 203 -QSDVWSYGVTVWELMTFGSKPYD 225 >2PVN-A nrPDB Length = 352 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 73/147 (49%), Gaps = 12/147 (8%) Query: 74 PHIIKLYQVI-----STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 P+I+KL ++ TP+ ++ EYV+ D+ + + + + R ++L A+D Sbjct: 107 PNIVKLLDIVRDQHSKTPS---LIFEYVNNT---DFKVLYPTLTDYDIRYYIYELLKALD 160 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 YCH ++HRD+KP NV++D + ++ D+GL+ G+ S + PE++ Sbjct: 161 YCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVD 220 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF 214 +D+WS G + ++ PF Sbjct: 221 LQDYDYSLDMWSLGCMFAGMIFRKEPF 247 >5LPV-A nrPDB Length = 296 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 29/211 (13%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKIL-------NRQKIRSLDVVGKIKREIQNLKLFRHP 74 +G G FG V + G VA+K L +R+ + ++ +GKIK H Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMAEMETIGKIK----------HR 73 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHR 132 +++ L + +V E++ G L D + K V+ + R I SA Sbjct: 74 NLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFL 133 Query: 133 HM-----VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEV 184 H ++HRD+K NVLLD ++ A+++DFG++ +MS + + T G+P Y PE Sbjct: 134 HHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 + D++S GV+L LL G P D Sbjct: 194 YQS-FRCSTKGDVYSYGVVLLELLTGKRPTD 223 >5LPZ-A nrPDB Length = 332 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 29/211 (13%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKIL-------NRQKIRSLDVVGKIKREIQNLKLFRHP 74 +G G FG V + G VA+K L +R+ + ++ +GKIK H Sbjct: 25 IGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFMAEMETIGKIK----------HR 73 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHR 132 +++ L + +V E++ G L D + K V+ + R I SA Sbjct: 74 NLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFL 133 Query: 133 HM-----VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEV 184 H ++HRD+K NVLLD ++ A+++DFG++ +MS + + T G+P Y PE Sbjct: 134 HHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEY 193 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 + D++S GV+L LL G P D Sbjct: 194 YQS-FRCSTKGDVYSYGVVLLELLTGKRPTD 223 >3CJF-A nrPDB Length = 309 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 121/277 (43%), Gaps = 36/277 (12%) Query: 18 LGDTLGVGTFGKV----KIG-EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF- 71 LG LG G FG+V G + T VAVK+L S + + + LK+ Sbjct: 31 LGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHS-----EHRALMSELKILI 85 Query: 72 ---RHPHIIKLYQVISTPTDFFMVM-EYVSGGELFDYICKHGRVEEMEARRLFQ------ 121 H +++ L + P MV+ E+ G L Y+ + R E + + L++ Sbjct: 86 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYL-RSKRNEFVPYKDLYKDFLTLE 144 Query: 122 -------QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTS 173 Q+ +++ +HRDL N+LL KI DFGL+ ++ D +++R Sbjct: 145 HLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG 204 Query: 174 CGS--PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF-KKIRGG 229 + APE I R+Y + D+WS GV+L+ + G P+ + F ++++ G Sbjct: 205 DARLPLKWMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEG 263 Query: 230 V-FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 P+Y + ++ +P +R T ++ EH Sbjct: 264 TRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >2BUJ-A nrPDB Length = 317 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/276 (25%), Positives = 117/276 (42%), Gaps = 42/276 (15%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVK--ILNRQKIRSLDVVGKIKREIQNLKLFR 72 HY+ LG G F V + E GH A+K + + Q+ R + +RE +LF Sbjct: 30 HYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDRE-----EAQREADMHRLFN 84 Query: 73 HPHIIKLYQVI----STPTDFFMVMEYVSGGELFDYIC----KHGRVEEMEARRLFQQIL 124 HP+I++L + ++++ + G L++ I K + E + L I Sbjct: 85 HPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGIC 144 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-----------MSDGEFLRTS 173 ++ H HRDLKP N+LL + D G N ++ ++ Sbjct: 145 RGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 174 CGSPNYAAPEVISGRLYA--GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF 231 C + +Y APE+ S + + D+WS G +LYA++ G P+D +F+K Sbjct: 205 C-TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD-----MVFQKGDSVAL 258 Query: 232 YIPEYL--------NRSVATLLMHMLQVDPLKRATI 259 + L + ++ LL M+ VDP +R I Sbjct: 259 AVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHI 294 >3NIE-A nrPDB Length = 429 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 97/226 (42%), Gaps = 35/226 (15%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y + +G G++G V + + VA+K +NR L +I REI L + Sbjct: 29 NYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRM-FEDLIDCKRILREITILNRLKSD 87 Query: 75 HIIKLYQVISTPTDF------FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +II+L+ +I P D ++V+E ++ +L + E + + +L Sbjct: 88 YIIRLHDLI-IPEDLLKFDELYIVLE-IADSDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEF------------------ 169 + H ++HRDLKP N LL+ + KI DFGL+ + SD + Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 170 -------LRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL 208 L + + Y APE+I + +DIWS G I LL Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >4R7H-A nrPDB Length = 343 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/281 (24%), Positives = 123/281 (43%), Gaps = 40/281 (14%) Query: 18 LGDTLGVGTFGKV------KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-L 70 G TLG G FGKV +G+ KVAVK+L + D + E++ + L Sbjct: 54 FGKTLGAGAFGKVVEATAFGLGKEDAV-LKVAVKML--KSTAHADEKEALMSELKIMSHL 110 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV------------------- 111 +H +I+ L + ++ EY + G+L +++ + Sbjct: 111 GQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKED 170 Query: 112 -EEMEARRLFQ---QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSD 166 +E R L Q+ + + +HRD+ NVLL AKI DFGL+ ++M+D Sbjct: 171 GRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND 230 Query: 167 GEFL-RTSCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF 223 ++ + + P + APE I +Y + D+WS G++L+ + G P+ V + F Sbjct: 231 SNYIVKGNARLPVKWMAPESIFDSVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 289 Query: 224 KKI--RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 K+ G P + +++ +++ ++P R T + I Sbjct: 290 YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >5VDK-A nrPDB Length = 297 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 54/275 (19%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-------LFR 72 + +GVG FG V +L G A+K RS+ ++ E L L Sbjct: 21 EKIGVGEFGTVYKCIKRLDGCVYAIK-------RSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVD 128 HPH+++ Y + + EY +GG L I ++ + EE + + + QI ++ Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 129 YCHRHMVVHRDLKPENV-----------------------LLDAHMNAKIADFGLSNMMS 165 Y H +VH D+KP N+ L A++ KI D G + ++ Sbjct: 134 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 193 Query: 166 DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT---L 222 + G + A E++ P+ DI++ G+ + A+ G E +PT Sbjct: 194 KP---KVEEGDSRFLANEILQEDYRHLPKADIFALGLTI-AVAAGA-----ESLPTNGAA 244 Query: 223 FKKIRGGVF-YIPEYLNRSVATLLMHMLQVDPLKR 256 + IR G F +P+ L+ S ++LL +M+Q D +R Sbjct: 245 WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQR 279 >5M07-A nrPDB Length = 276 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 101/243 (41%), Gaps = 24/243 (9%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V Y + LG G+V + +H A+K+L+ + + +RE + Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVD 128 HPHI++++ ++ M+YV G + ++ + E + + A+D Sbjct: 87 LFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAK----IADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 Y H+ ++HRD+ P NV+L + +ADFG+++ P+Y APE+ Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS-------------QPSYPAPEL 193 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV----PTLFKKIRGGVFYIPEYLNRS 240 +G G D ++ + L G P D H P R + + L+R+ Sbjct: 194 SAGADVDG-RADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLSRA 252 Query: 241 VAT 243 +AT Sbjct: 253 LAT 255 >3QD2-B nrPDB Length = 332 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/223 (25%), Positives = 99/223 (44%), Gaps = 20/223 (8%) Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME---ARRLF 120 +I+ + F + + Q S ++ M+ L D++ + +E+ E +F Sbjct: 111 KIRRMDPFSTKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIF 170 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-------- 172 QI AV++ H ++HRDLKP N+ K+ DFGL M E +T Sbjct: 171 IQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 230 Query: 173 -----SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG-TLPFDDEHVPTLFKKI 226 G+ Y +PE I G Y+ +VDI+S G+IL+ LL + + + T + + Sbjct: 231 ATHTGQVGTKLYMSPEQIHGNNYSH-KVDIFSLGLILFELLYSFSTQMERVRIITDVRNL 289 Query: 227 RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + + + +Y + ++ ML P +R DI E+ F+ Sbjct: 290 KFPLLFTQKYPQEHM--MVQDMLSPSPTERPEATDIIENAIFE 330 >1LUF-A nrPDB Length = 343 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/248 (25%), Positives = 106/248 (42%), Gaps = 37/248 (14%) Query: 22 LGVGTFGKV-KIGEHQLTGHK----VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 +G G FG+V + L ++ VAVK+L + S D+ +RE + F +P+I Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA--SADMQADFQREAALMAEFDNPNI 112 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDY--------ICK--------HGRVEE------- 113 +KL V + ++ EY++ G+L ++ +C RV Sbjct: 113 VKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLS 172 Query: 114 -MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 172 E + +Q+ + + Y VHRDL N L+ +M KIADFGLS + ++ + Sbjct: 173 CAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKA 232 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDD-EHVPTLFKKIR 227 + PE I Y E D+W+ GV+L+ + G P+ H ++ Sbjct: 233 DGNDAIPIRWMPPESIFYNRYTT-ESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRD 291 Query: 228 GGVFYIPE 235 G + PE Sbjct: 292 GNILACPE 299 >2I6L-A nrPDB Length = 320 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 73/308 (23%), Positives = 123/308 (39%), Gaps = 58/308 (18%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G G V +VA+K + +S V REI+ ++ H +I+K+++ Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS---VKHALREIKIIRRLDHDNIVKVFE 75 Query: 82 VI----STPTD----------FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++ S TD ++V EY+ + + G + E AR Q+L + Sbjct: 76 ILGPSGSQLTDDVGSLTELNSVYIVQEYMETD--LANVLEQGPLLEEHARLFMYQLLRGL 133 Query: 128 DYCHRHMVVHRDLKPENVLLDAH-MNAKIADFGLSNMM----SDGEFLRTSCGSPNYAAP 182 Y H V+HRDLKP N+ ++ + KI DFGL+ +M S L + Y +P Sbjct: 134 KYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSP 193 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH-----------VPTLFKKIRGGVF 231 ++ +D+W+ G I +L G F H +P + ++ R + Sbjct: 194 RLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELL 253 Query: 232 -YIPEY------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDL 272 IP Y ++R L +L P+ R T ++ H + + Sbjct: 254 SVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPY----M 309 Query: 273 PSYLFPED 280 Y FP D Sbjct: 310 SIYSFPMD 317 >3Q4U-A nrPDB Length = 301 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 97/214 (45%), Gaps = 33/214 (15%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 L + +G G +G+V G Q G VAVKI + + +S + E+ N + RH +I+ Sbjct: 12 LLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSW----FRETELYNTVMLRHENIL 65 Query: 78 KLYQVISTP----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 T T +++ Y G L+DY+ + ++ + R+ I S + + H Sbjct: 66 GFIASDMTSRHSSTQLWLITHYHEMGSLYDYL-QLTTLDTVSCLRIVLSIASGLAHLHIE 124 Query: 134 M--------VVHRDLKPENVLLDAHMNAKIADFGL-------SNMMSDGEFLRTSCGSPN 178 + + HRDLK +N+L+ + IAD GL +N + G R G+ Sbjct: 125 IFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRV--GTKR 182 Query: 179 YAAPEVISGRLYAG-----PEVDIWSCGVILYAL 207 Y APEV+ + VDIW+ G++L+ + Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >3LZB-A nrPDB Length = 327 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 97/204 (47%), Gaps = 13/204 (6%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQ--KIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G FG V G G KV + + ++ + S +I E + +PH+ + Sbjct: 22 VLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCR 81 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ---QILSAVDYCHRHMV 135 L + T T ++ + + G L DY+ +H + + ++ L QI ++Y + Sbjct: 82 LLGICLTST-VQLITQLMPFGCLLDYVREHK--DNIGSQYLLNWCVQIAKGMNYLEDRRL 138 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP-NYAAPEVISGRLYAG 192 VHRDL NVL+ + KI DFGL+ ++ + E+ P + A E I R+Y Sbjct: 139 VHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTH 198 Query: 193 PEVDIWSCGVILYALLC-GTLPFD 215 + D+WS GV ++ L+ G+ P+D Sbjct: 199 -QSDVWSYGVTVWELMTFGSKPYD 221 >6GQK-A nrPDB Length = 328 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 73/274 (26%), Positives = 119/274 (43%), Gaps = 33/274 (12%) Query: 18 LGDTLGVGTFGKVKIGEHQL-----TGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LF 71 G TLG G FGKV Q VAVK+L + S + + E++ L L Sbjct: 45 FGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREA-LMSELKVLSYLG 102 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE----EMEARRLFQ------ 121 H +I+ L + ++ EY G+L +++ + R E ++ L++ Sbjct: 103 NHENIVNLLGACTHGGPTLVITEYCCYGDLLNFL-RRKRDEFVPYKVAPEDLYKDFLTLE 161 Query: 122 -------QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFL-RT 172 Q+ + + +HRDL N+LL KI DFGL+ ++ +D ++ + Sbjct: 162 HLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKG 221 Query: 173 SCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGV 230 + P + APE I +Y E D+WS G+ L+ L G+ P+ V + F K+ Sbjct: 222 NARLPVKWMAPESIFNSVYTF-ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEG 280 Query: 231 FYI--PEYLNRSVATLLMHMLQVDPLKRATIKDI 262 F + PEY + ++ DP KR T K I Sbjct: 281 FRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQI 314 >4O2Z-A nrPDB Length = 377 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 90/202 (44%), Gaps = 20/202 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L LG+G +G TG KV++K R R ++ ++ REI ++ F H + Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRDVEDGKRVLREIDMMRFFHHEN 105 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELF----------DYICKHGRV-EEMEARRLFQQIL 124 ++ + ++ + EY S +++ + + + +V EE + QIL Sbjct: 106 LLNVVNILPP-----LKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQIL 160 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSCGSPNYAAP 182 + Y H V HRDLKP N++ + KI DFGLS + D + L + Y P Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSV-DVPYSELTDYVITRWYRPP 219 Query: 183 EVISGRLYAGPEVDIWSCGVIL 204 E++ VDIWS G I Sbjct: 220 ELLLENTNYSTAVDIWSVGCIF 241 >6FER-A nrPDB Length = 309 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 69/283 (24%), Positives = 120/283 (42%), Gaps = 44/283 (15%) Query: 20 DTLGVGTFGKVKIGEHQ-------------LTGHK---VAVKILNRQKIRSLDVVGKIKR 63 + LG G FG+V + E + ++ ++ VAVK+L + + + Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK--NARNDFLK 72 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------RVEE 113 EI+ + + P+II L V T M+ EY+ G+L ++ +H V Sbjct: 73 EIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSY 132 Query: 114 MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS 173 + + QI S + Y VHRDL N L+ + KIADFG+S + G++ R Sbjct: 133 TNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQ 192 Query: 174 CGSP---NYAAPE-VISGRLYAGPEVDIWSCGVILYA--LLCGTLPF---DDEHV---PT 221 + + + E ++ G+ D+W+ GV L+ C P+ DE V Sbjct: 193 GRAVLPIRWMSWESILLGKFTTAS--DVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTG 250 Query: 222 LFKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDI 262 F + +G Y+P+ SV L++ + D R + ++I Sbjct: 251 EFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >3MY0-A nrPDB Length = 305 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/214 (28%), Positives = 98/214 (45%), Gaps = 33/214 (15%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 L + +G G +G+V G G VAVKI + + +S + EI N L RH +I+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSW----FRETEIYNTVLLRHDNIL 65 Query: 78 KLYQVISTP----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 T T +++ Y G L+D++ + +E A RL + +A H H Sbjct: 66 GFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT-LEPHLALRL--AVSAACGLAHLH 122 Query: 134 M----------VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTS----CGSPN 178 + + HRD K NVL+ +++ IAD GL+ M S G ++L G+ Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 179 YAAPEVISGRLYAG-----PEVDIWSCGVILYAL 207 Y APEV+ ++ DIW+ G++L+ + Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEI 216 >5U6C-A nrPDB Length = 315 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 113/270 (41%), Gaps = 29/270 (10%) Query: 17 VLGDTLGVGTFGKVKIG---EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +LG LG G FG V G + T KVAVK + S + + E +K F H Sbjct: 39 ILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDN-SSQREIEEFLSEAACMKDFSH 97 Query: 74 PHIIKLYQV--------ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 P++++L V I P M+Y G+L Y+ + R+E Q +L Sbjct: 98 PNVMRLLGVCIEMSSQGIPKPMVILPFMKY---GDLHTYLL-YSRLETGPKHIPLQTLLK 153 Query: 126 -------AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP- 177 ++Y +HRDL N +L M +ADFGLS + G++ R + Sbjct: 154 FMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKM 213 Query: 178 --NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKK-IRGGVFYI 233 + A E ++ R+Y + D+W+ GV ++ + G P+ ++ + G Sbjct: 214 PVKWIAIESLADRVYTS-KSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 272 Query: 234 PEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 PE + ++ + DPL R T +R Sbjct: 273 PEDCLDELYEIMYSCWRTDPLDRPTFSVLR 302 >4XLV-A nrPDB Length = 328 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 124/286 (43%), Gaps = 42/286 (14%) Query: 22 LGVGTFGKVKIGEHQ--LTGH---KVAVKILN-----RQKIRSLDVVGKIKREIQNLKLF 71 LG G+FG V G + + G +VAVK +N R++I L+ E +K F Sbjct: 47 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN-------EASVMKGF 99 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--------CKHGR----VEEMEARRL 119 H+++L V+S +VME ++ G+L Y+ GR ++EM ++ Sbjct: 100 TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEM--IQM 157 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS--- 176 +I + Y + VHRDL N ++ KI DFG++ + + ++ R Sbjct: 158 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 217 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR-GGVFYIP 234 + APE + ++ D+WS GV+L+ + P+ + K + GG P Sbjct: 218 VRWMAPESLKDGVFTTSS-DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQP 276 Query: 235 EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDL-PSYLFPE 279 + V L+ Q +P R T +I K DL PS FPE Sbjct: 277 DNCPERVTDLMRMCWQFNPNMRPTFLEIV--NLLKDDLHPS--FPE 318 >5HLW-A nrPDB Length = 299 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 18/212 (8%) Query: 18 LGDTLGVGTFGKVKIGEH-QLTGHKV--AVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 + +G G FG V G G K+ AVK LNR I + V + E +K F HP Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHP 81 Query: 75 HIIKLYQV-ISTPTDFFMVMEYVSGGELFDYI---CKHGRVEEMEARRLFQQILSAVDYC 130 +++ L + + + +V+ Y+ G+L ++I + V+++ L Q+ + Y Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL--QVAKGMKYL 139 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL----RTSCGSP-NYAAPEVI 185 VHRDL N +LD K+ADFGL+ M D E+ +T P + A E + Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 186 SGRLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 + + + D+WS GV+L+ L+ G P+ D Sbjct: 200 QTQKFT-TKSDVWSFGVLLWELMTRGAPPYPD 230 >2Y4I-B nrPDB Length = 319 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 105/230 (45%), Gaps = 24/230 (10%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 +G+ +G G FG+V G +VA+++++ ++ D + KRE+ + RH +++ Sbjct: 37 IGELIGKGRFGQVYHGRWH---GEVAIRLIDIERDNE-DQLKAFKREVMAYRQTRHENVV 92 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM-EARRLFQQILSAVDYCHRHMVV 136 +P ++ G L+ + V ++ + R++ Q+I+ + Y H ++ Sbjct: 93 LFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL 152 Query: 137 HRDLKPENVLLDAHMNAK--IADFGL---SNMMSDG---EFLRTSCGSPNYAAPEVI--- 185 H+DLK +NV D N K I DFGL S ++ G + LR G + APE+I Sbjct: 153 HKDLKSKNVFYD---NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL 209 Query: 186 -----SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV 230 +L D+++ G I Y L PF + + ++ G+ Sbjct: 210 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGM 259 >3RP9-A nrPDB Length = 458 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 94/227 (41%), Gaps = 37/227 (16%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y + +G G++G V +L VA+K + R L +I REI L H H Sbjct: 55 YEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRV-FEDLIDCKRILREIAILNRLNHDH 113 Query: 76 IIKLYQVISTPTD------FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 ++K+ ++ P D ++V+E ++ + + E+ + L +L V Y Sbjct: 114 VVKVLDIV-IPKDVEKFDELYVVLE-IADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKY 171 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---------------SDGEFLRTSC 174 H ++HRDLKP N L++ + K+ DFGL+ + D L T Sbjct: 172 VHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFP 231 Query: 175 GSPN-------------YAAPEVISGRLYAGPEVDIWSCGVILYALL 208 + N Y APE+I + +D+WS G I LL Sbjct: 232 HTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >5VC6-A nrPDB Length = 289 Score = 65.1 bits (157), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 114/271 (42%), Gaps = 32/271 (11%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G G FG V +L G A+K + S+D ++ + L +H H+++ Sbjct: 17 EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRY 76 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRV----EEMEARRLFQQILSAVDYCHRHMV 135 + + + EY +GG L D I ++ R+ +E E + L Q+ + Y H + Sbjct: 77 FSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSL 136 Query: 136 VHRDLKPENVLL----------------DAHMNA---KIADFGLSNMMSDGEFLRTSCGS 176 VH D+KP N+ + D N KI D G +S + G Sbjct: 137 VHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ---VEEGD 193 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGV-ILYALLCGTLPFDDEHVPTLFKKIRGGVF-YIP 234 + A EV+ P+ DI++ + ++ A LP + + + +IR G IP Sbjct: 194 SRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQ----WHEIRQGRLPRIP 249 Query: 235 EYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 + L++ LL M+ DP +R + + +H Sbjct: 250 QVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >6FEX-A nrPDB Length = 321 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 40/237 (16%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKI-LNRQKIRSLDVVGKIKR-------------EI 65 + LG G FG+V + E V++ LN +K L V KI R E+ Sbjct: 22 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEV 81 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-------- 117 + + + P+II+L V M+ +Y+ G+L ++ H ++E+ A Sbjct: 82 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH-QLEDKAAEGAPGDPTI 140 Query: 118 ------RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR 171 + QI S + Y VHRDL N L+ + KIADFG+S + G++ R Sbjct: 141 SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR 200 Query: 172 TSCGSP---NYAAPE-VISGRLYAGPEVDIWSCGVILYA--LLCGTLPFD---DEHV 219 + + A E ++ G+ D+W+ GV L+ +LC PF DE V Sbjct: 201 VQGRAVLPIRWMAWECILMGKFTTAS--DVWAFGVTLWEVLMLCRAQPFGQLTDEQV 255 >5X02-A nrPDB Length = 347 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 70/283 (24%), Positives = 117/283 (41%), Gaps = 44/283 (15%) Query: 18 LGDTLGVGTFGKV---------KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G LG G FGKV K G +VAVK+L ++K S + + Sbjct: 52 FGKVLGSGAFGKVMNATAYGISKTG----VSIQVAVKML-KEKADSSEREALMSELKMMT 106 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--------------KHGRVEEM 114 +L H +I+ L + +++ EY G+L +Y+ R+EE Sbjct: 107 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 166 Query: 115 EARRLFQ---------QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMM 164 E + Q+ +++ VHRDL NVL+ KI DFGL+ ++M Sbjct: 167 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 226 Query: 165 SDGEF-LRTSCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPT 221 SD + +R + P + APE + +Y + D+WS G++L+ + G P+ V Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLFEGIYT-IKSDVWSYGILLWEIFSLGVNPYPGIPVDA 285 Query: 222 LFKKIRGGVFYI--PEYLNRSVATLLMHMLQVDPLKRATIKDI 262 F K+ F + P Y + ++ D KR + ++ Sbjct: 286 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >3C1X-A nrPDB Length = 373 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 101/212 (47%), Gaps = 18/212 (8%) Query: 18 LGDTLGVGTFGKVKIGEH-QLTGHKV--AVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 + +G G FG V G G K+ AVK LNR I + V + E +K F HP Sbjct: 93 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHP 150 Query: 75 HIIKLYQV-ISTPTDFFMVMEYVSGGELFDYI---CKHGRVEEMEARRLFQQILSAVDYC 130 +++ L + + + +V+ Y+ G+L ++I + V+++ L Q+ + + Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL--QVAKGMKFL 208 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF----LRTSCGSP-NYAAPEVI 185 VHRDL N +LD K+ADFGL+ M D EF +T P + A E + Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL 268 Query: 186 SGRLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 + + + D+WS GV+L+ L+ G P+ D Sbjct: 269 QTQKFT-TKSDVWSFGVLLWELMTRGAPPYPD 299 >6HMD-A nrPDB Length = 365 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 69/143 (48%), Gaps = 6/143 (4%) Query: 75 HIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 +IIKL + P +V EY++ D+ + + + + R ++L A+DYCH Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCHS 165 Query: 133 HMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 166 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMY 225 Query: 192 GPEVDIWSCGVILYALLCGTLPF 214 +D+WS G +L +++ PF Sbjct: 226 DYSLDMWSLGCMLASMIFRREPF 248 >4XUF-A nrPDB Length = 297 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 70/283 (24%), Positives = 117/283 (41%), Gaps = 44/283 (15%) Query: 18 LGDTLGVGTFGKV---------KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G LG G FGKV K G +VAVK+L ++K S + + Sbjct: 13 FGKVLGSGAFGKVMNATAYGISKTG----VSIQVAVKML-KEKADSSEREALMSELKMMT 67 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--------------KHGRVEEM 114 +L H +I+ L + +++ EY G+L +Y+ R+EE Sbjct: 68 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 127 Query: 115 EARRLFQ---------QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMM 164 E + Q+ +++ VHRDL NVL+ KI DFGL+ ++M Sbjct: 128 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 187 Query: 165 SDGEF-LRTSCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPT 221 SD + +R + P + APE + +Y + D+WS G++L+ + G P+ V Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLFEGIYT-IKSDVWSYGILLWEIFSLGVNPYPGIPVDA 246 Query: 222 LFKKIRGGVFYI--PEYLNRSVATLLMHMLQVDPLKRATIKDI 262 F K+ F + P Y + ++ D KR + ++ Sbjct: 247 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >3G0E-A nrPDB Length = 336 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/275 (26%), Positives = 114/275 (41%), Gaps = 33/275 (12%) Query: 18 LGDTLGVGTFGKV-KIGEHQL----TGHKVAVKILNRQKIRSLDVVGKIKREIQNLK-LF 71 G TLG G FGKV + + L VAVK+L L + E++ L L Sbjct: 50 FGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSA--HLTEREALMSELKVLSYLG 107 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDY--------ICKHGRVEEMEAR------ 117 H +I+ L + ++ EY G+L ++ IC ME Sbjct: 108 NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDL 167 Query: 118 ----RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEF-LR 171 Q+ + + +HRDL N+LL KI DFGL+ ++ +D + ++ Sbjct: 168 EDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVK 227 Query: 172 TSCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--R 227 + P + APE I +Y E D+WS G+ L+ L G+ P+ V + F K+ Sbjct: 228 GNARLPVKWMAPESIFNCVYTF-ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE 286 Query: 228 GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G PE+ + ++ DPLKR T K I Sbjct: 287 GFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQI 321 >4LRM-A nrPDB Length = 334 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 97/209 (46%), Gaps = 20/209 (9%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-------H 73 LG G FG V G G KV + + ++ + K +EI + + Sbjct: 26 VLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS--PKANKEILDEAYVMASVDNPGN 83 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ---QILSAVDYC 130 PH+ +L + T T ++ + + G L DY+ +H + + ++ L QI ++Y Sbjct: 84 PHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHK--DNIGSQYLLNWCVQIAKGMNYL 140 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP-NYAAPEVISG 187 +VHRDL NVL+ + KI DFGL+ ++ + E+ P + A E I Sbjct: 141 EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILH 200 Query: 188 RLYAGPEVDIWSCGVILYALLC-GTLPFD 215 R+Y + D+WS GV ++ L+ G+ P+D Sbjct: 201 RIYTH-QSDVWSYGVTVWELMTFGSKPYD 228 >6BSD-A nrPDB Length = 876 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 63/245 (25%), Positives = 102/245 (41%), Gaps = 50/245 (20%) Query: 20 DTLGVGTFGKVKIGE--------------HQLTGHK--VAVKILNRQKIRSLDVVGKIKR 63 + LG G FG+V + E + GH VAVKIL + + + Sbjct: 577 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK--NARNDFLK 634 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR------ 117 E++ + + P+II+L V M+ +Y+ G+L ++ H ++E+ A Sbjct: 635 EVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAH-QLEDKAAEGAPGDG 693 Query: 118 --------------RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM 163 + QI S + Y VHRDL N L+ + KIADFG+S Sbjct: 694 QAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRN 753 Query: 164 MSDGEFLRTSCGSP---NYAAPE-VISGRLYAGPEVDIWSCGVILYA--LLCGTLPFD-- 215 + G++ R + + A E ++ G+ D+W+ GV L+ +LC PF Sbjct: 754 LYAGDYYRVQGRAVLPIRWMAWECILMGKFTTA--SDVWAFGVTLWEVLMLCRAQPFGQL 811 Query: 216 -DEHV 219 DE V Sbjct: 812 TDEQV 816 >3MDY-A nrPDB Length = 337 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 97/211 (45%), Gaps = 35/211 (16%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G+V +G+ + G KVAVK+ + + + EI L RH +I+ Sbjct: 45 IGKGRYGEVWMGKWR--GEKVAVKVF----FTTEEASWFRETEIYQTVLMRHENILGFIA 98 Query: 82 V----ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD-YCHRHM-- 134 + T +++ +Y G L+DY+ + ++A+ + + S+V CH H Sbjct: 99 ADIKGTGSWTQLYLITDYHENGSLYDYL----KSTTLDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 135 --------VVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFL----RTSCGSPNYAA 181 + HRDLK +N+L+ + IAD GL+ +SD + T G+ Y Sbjct: 155 FSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 182 PEVISGRL-----YAGPEVDIWSCGVILYAL 207 PEV+ L + D++S G+IL+ + Sbjct: 215 PEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >5WNO-A nrPDB Length = 330 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 108/252 (42%), Gaps = 20/252 (7%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHK-----VAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 L LG G FG V G + K VA+K+ + ++ +++ E N+ R Sbjct: 26 LDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEML----EEATNMFRLR 81 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF---QQILSAVDY 129 H +++K+ +V Y G L +++ H E + AR QI S + Y Sbjct: 82 HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK--ENLGAREQVLYCYQIASGMQY 139 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVIS 186 + VVHRDL NVL+ + +I DFGLS ++ +D +++ + + A E+ S Sbjct: 140 LEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 187 GRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR-GGVFYIPEYLNRSVATL 244 Y D+W+ GV + ++ G P+ ++ ++ G P ++ + Sbjct: 200 KHCYTHAS-DVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQE 258 Query: 245 LMHMLQVDPLKR 256 L+ DP R Sbjct: 259 LLRCWMADPKSR 270 >3G2F-A nrPDB Length = 336 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 100/237 (42%), Gaps = 45/237 (18%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKIL---NRQKIRSLDVVGKIKREIQNLKLFRHP 74 L + +G G +G V G L VAVK+ NRQ + ++ I + L H Sbjct: 17 LLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFIN-------EKNIYRVPLMEHD 67 Query: 75 HIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 +I + T ++ +VMEY G L Y+ H + + + RL + + Y Sbjct: 68 NIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHSVTRGLAY 126 Query: 130 CHRHM---------VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--------- 171 H + + HRDL NVL+ I+DFGLS ++ +R Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 172 TSCGSPNYAAPEVISGRLY------AGPEVDIWSCGVILYALL--CGTLPFDDEHVP 220 + G+ Y APEV+ G + A +VD+++ G+I + + C L F E VP Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDL-FPGESVP 242 >4CRL-A nrPDB Length = 406 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 87/208 (41%), Gaps = 21/208 (10%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 G +G GT+G V + + + ++I + REI L+ +HP++I Sbjct: 27 GCKVGRGTYGHVYKAKRKDGKDDKDYAL---KQIEGTGISMSACREIALLRELKHPNVIS 83 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME----------ARRLFQQILSAVD 128 L +V + D + + + +I K R + + L QIL + Sbjct: 84 LQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIH 143 Query: 129 YCHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDG----EFLRTSCGSPNYA 180 Y H + V+HRDLKP N+L+ KIAD G + + + L + Y Sbjct: 144 YLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYR 203 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALL 208 APE++ G + +DIW+ G I LL Sbjct: 204 APELLLGARHYTKAIDIWAIGCIFAELL 231 >2PZI-A nrPDB Length = 681 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 96/212 (45%), Gaps = 22/212 (10%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIG-EHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 Q + G + G Y + + G G + + + + G V +K L + +R Sbjct: 71 QLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER 130 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKHGRVEEMEAR 117 Q L HP I++++ + TD ++VMEYV G L K ++ EA Sbjct: 131 --QFLAEVVHPSIVQIFNFVEH-TDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAI 185 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 177 +IL A+ Y H +V+ DLKPEN++L K+ D G + ++ +L G+P Sbjct: 186 AYLLEILPALSYLHSIGLVYNDLKPENIML-TEEQLKLIDLGAVSRINSFGYL---YGTP 241 Query: 178 NYAAPEVISGRLYAGPEV--DIWSCGVILYAL 207 + APE++ GP V DI++ G L AL Sbjct: 242 GFQAPEIVR----TGPTVATDIYTVGRTLAAL 269 >1PY5-A nrPDB Length = 326 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 103/216 (47%), Gaps = 35/216 (16%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 VL +++G G FG+V G+ + G +VAVKI + ++ RS + EI + RH +I Sbjct: 32 VLQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFR----EAEIYQTVMLRHENI 85 Query: 77 IKLYQVIS----TPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCH 131 + + T T ++V +Y G LFDY+ ++ VE M + + +A H Sbjct: 86 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGM----IKLALSTASGLAH 141 Query: 132 RHM----------VVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTS--CGS 176 HM + HRDLK +N+L+ + IAD GL+ + +D + + G+ Sbjct: 142 LHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGT 201 Query: 177 PNYAAPEVISGRLY-----AGPEVDIWSCGVILYAL 207 Y APEV+ + + DI++ G++ + + Sbjct: 202 KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEI 237 >3RAW-A nrPDB Length = 381 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 68/254 (26%), Positives = 108/254 (42%), Gaps = 55/254 (21%) Query: 16 YVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKIL-NRQKIRS-----LDVVGKIKREIQNL 68 Y + LG GTFGKV + +H +VA+KI+ N K R ++V+ KIK + + Sbjct: 53 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKEN 112 Query: 69 KLF---------RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL 119 K H H+ ++++ T E++ Y H R + Sbjct: 113 KFLCVLMSDWFNFHGHMCIAFELLGKNT-----FEFLKENNFQPYPLPH-------VRHM 160 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLL---------DAHMNA----------KIADFGL 160 Q+ A+ + H + + H DLKPEN+L + H + ++ADFG Sbjct: 161 AYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGS 220 Query: 161 SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----DD 216 + D E T + +Y PEVI +A P D+WS G IL+ G F + Sbjct: 221 ATF--DHEHHTTIVATRHYRPPEVILELGWAQP-CDVWSIGCILFEYYRGFTLFQTHENR 277 Query: 217 EHVPTLFKKIRGGV 230 EH+ + +KI G + Sbjct: 278 EHL-VMMEKILGPI 290 >4Y12-A nrPDB Length = 375 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 96/212 (45%), Gaps = 22/212 (10%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIG-EHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 Q + G + G Y + + G G + + + + G V +K L + +R Sbjct: 110 QLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER 169 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTD------FFMVMEYVSGGELFDYICKHGRVEEMEAR 117 Q L HP I++++ + TD ++VMEYV G L K ++ EA Sbjct: 170 --QFLAEVVHPSIVQIFNFVEH-TDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAI 224 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 177 +IL A+ Y H +V+ DLKPEN++L K+ D G + ++ +L G+P Sbjct: 225 AYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY---GTP 280 Query: 178 NYAAPEVISGRLYAGPEV--DIWSCGVILYAL 207 + APE++ GP V DI++ G L AL Sbjct: 281 GFQAPEIVR----TGPTVATDIYTVGRTLAAL 308 >5UNP-A nrPDB Length = 369 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 101/234 (43%), Gaps = 50/234 (21%) Query: 16 YVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKIL-NRQKIRS-----LDVVGKIKRE---- 64 Y + TLG GTFG+V + +H+ G +VA+KI+ N +K + ++V+ KI + Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDN 95 Query: 65 ----IQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL 119 +Q F H H+ ++++ T +++ Y + R + Sbjct: 96 KNLCVQMFDWFDYHGHMCISFELLGLST-----FDFLKDNNYLPYPIH-------QVRHM 143 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLL---DAHMN----------------AKIADFGL 160 Q+ AV + H + + H DLKPEN+L D + ++ DFG Sbjct: 144 AFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGS 203 Query: 161 SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 + D E T + +Y APEVI ++ P D+WS G I++ G F Sbjct: 204 ATF--DHEHHSTIVSTRHYRAPEVILELGWSQP-CDVWSIGCIIFEYYVGFTLF 254 >4IAN-A nrPDB Length = 358 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 71/252 (28%), Positives = 117/252 (46%), Gaps = 39/252 (15%) Query: 10 RVKIG------HYVLGDTLGVGTFGKV-KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62 RV IG + V G T G G F V + ++ +VAVKI IR+ +++ K Sbjct: 21 RVNIGEVLDKRYNVYGYT-GQGVFSNVVRARDNARANQEVAVKI-----IRNNELMQKTG 74 Query: 63 -REIQNLKLFRHP------HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR---VE 112 +E++ LK H ++L++ +V E +S L + + K+G+ + Sbjct: 75 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMN-LREVLKKYGKDVGLH 133 Query: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLR 171 R QQ+ A+ R ++H D+KP+N+L++ K+ DFG ++ ++D + + Sbjct: 134 IKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-IT 192 Query: 172 TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLF----- 223 S Y APE+I G+ Y +D+WS G LY L G + F + H+ L Sbjct: 193 PYLVSRFYRAPEIIIGKSY-DYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 251 Query: 224 ----KKIRGGVF 231 K IR GVF Sbjct: 252 KMPNKMIRKGVF 263 >3SOC-A nrPDB Length = 322 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 102/224 (45%), Gaps = 37/224 (16%) Query: 25 GTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQV-- 82 G FG V + QL VAVKI Q +S + + E+ +L +H +I++ Sbjct: 35 GRFGCV--WKAQLLNEYVAVKIFPIQDKQSW----QNEYEVYSLPGMKHENILQFIGAEK 88 Query: 83 --ISTPTDFFMVMEYVSGGELFDYICKH-------GRVEEMEARRL--FQQILSAVDYCH 131 S D +++ + G L D++ + + E AR L + + + H Sbjct: 89 RGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGH 148 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS---CGSPNYAAPEVISGR 188 + + HRD+K +NVLL ++ A IADFGL+ G+ + G+ Y APEV+ G Sbjct: 149 KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGA 208 Query: 189 LY----AGPEVDIWSCGVILYALL--CGT---------LPFDDE 217 + A +D+++ G++L+ L C LPF++E Sbjct: 209 INFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEE 252 >3PP0-A nrPDB Length = 338 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 96/217 (44%), Gaps = 16/217 (7%) Query: 21 TLGVGTFGKVKIGEHQLTGHKV----AVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 LG G FG V G G V A+K+L S +I E + P++ Sbjct: 24 VLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENT--SPKANKEILDEAYVMAGVGSPYV 81 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRHMV 135 +L + T T +V + + G L D++ ++ GR+ + QI + Y + Sbjct: 82 SRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRL 140 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAG 192 VHRDL NVL+ + + KI DFGL+ ++ E + G + A E I R + Sbjct: 141 VHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH 200 Query: 193 PEVDIWSCGVILYALLC-GTLPFDD---EHVPTLFKK 225 + D+WS GV ++ L+ G P+D +P L +K Sbjct: 201 -QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEK 236 >5AR8-A nrPDB Length = 326 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 93/210 (44%), Gaps = 17/210 (8%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 L G G V H +VAVK L+ + RE + L R +I+ + Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 99 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-----RLFQQILSAVDYCHRHM-- 134 + + P +V EY+ G L + + H + E + R+ +I V+Y H Sbjct: 100 ICNEPEFLGIVTEYMPNGSLNELL--HRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPP 157 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDGEFLRTSC----GSPNYAAPEVIS-- 186 ++H DLK +N+LLD + KIADFGLS MMS + + G+ Y PE Sbjct: 158 LLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG 217 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDD 216 + A + DI+S VI + +L PF+D Sbjct: 218 QKSRASIKHDIYSYAVITWEVLSRKQPFED 247 >4F9B-A nrPDB Length = 361 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 97/253 (38%), Gaps = 50/253 (19%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLT---GHKVAVK--ILNRQKIRSLDVVGKIKREIQNLKL 70 + + D +G GTF V + QL K+A+K I IR I E+Q L + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIR-------IAAELQCLTV 75 Query: 71 FR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 +++ + + M Y+ D + + E R + A+ Sbjct: 76 AGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL---NSLSFQEVREYMLNLFKALKR 132 Query: 130 CHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSN------------MMSDGEFLRTS--- 173 H+ +VHRD+KP N L + + + DFGL+ + S+ + R S Sbjct: 133 IHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 174 --------------CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----D 215 G+P + APEV++ +D+WS GVI +LL G PF D Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASD 252 Query: 216 DEHVPTLFKKIRG 228 D IRG Sbjct: 253 DLTALAQIMTIRG 265 >3VHK-A nrPDB Length = 368 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 72/150 (48%), Gaps = 7/150 (4%) Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGS--PN 178 Q+ +++ +HRDL N+LL KI DFGL+ ++ D +++R Sbjct: 208 QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLK 267 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF-KKIRGGV-FYIPE 235 + APE I R+Y + D+WS GV+L+ + G P+ + F ++++ G P+ Sbjct: 268 WMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPD 326 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIREH 265 Y + ++ +P +R T ++ EH Sbjct: 327 YTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 >5XD6-A nrPDB Length = 305 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 96/212 (45%), Gaps = 27/212 (12%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G++G+V G + +G A+K L+ K + + ++ + R +++ L Sbjct: 30 IGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEFLA----QVSMVSRLRQENVVALLG 84 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-----RLFQQILSAV------DYC 130 + EY G L D + HGR A+ Q++ AV +Y Sbjct: 85 YCVDGPLRVLAYEYAPNGSLHDIL--HGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYL 142 Query: 131 HRHM---VVHRDLKPENVLLDAHMNAKIADFGLSNMMSD-GEFLRTS--CGSPNYAAPE- 183 H V+HRD+K NVLL AKIADF LSN D L ++ G+ Y APE Sbjct: 143 HEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEY 202 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 ++G L + D++S GV+L LL G P D Sbjct: 203 AMTGTLST--KSDVYSFGVVLLELLTGRKPVD 232 >5X1R-A nrPDB Length = 302 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/258 (22%), Positives = 110/258 (42%), Gaps = 38/258 (14%) Query: 12 KIGHYVLGDTLGVGTFGKV-KIGEHQLTGHKVAVK------ILNRQKIRSLDVVGK---- 60 + + + + +G G FG V + +HQL +A+K + R S+ + G+ Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLE-RTIAIKEYMPTSLAKRNDDLSIGLRGERFGK 77 Query: 61 -----IKREIQNLKL---FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRV 111 + IQ +L F HP ++ + + +M ++ SG L + + ++ Sbjct: 78 TFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKI 137 Query: 112 EEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG-----LSNMMSD 166 +E RRL + SA++ H+ +HRD+ +N+ + + DFG + N+ + Sbjct: 138 DEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDE 197 Query: 167 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP-------FDDEHV 219 E + +P E G GP DI++ G +L+ L+ G+ P +D + Sbjct: 198 TEIVLKPGFAPIEQYTENSDGE--QGPWTDIYALGAVLHTLIVGSPPPVSVVRSIEDSYQ 255 Query: 220 PTLFKKIRGGVFYIPEYL 237 P ++ G Y PE L Sbjct: 256 PLTERRPAG---YSPELL 270 >3I81-A nrPDB Length = 315 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 93/211 (44%), Gaps = 35/211 (16%) Query: 22 LGVGTFGKVKIGEHQLT-----GHKVAVKILN-----RQKIRSLDVVGKIKREIQNLKLF 71 LG G+FG V G + +VA+K +N R++I L+ E +K F Sbjct: 26 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN-------EASVMKEF 78 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR------------RL 119 H+++L V+S ++ME ++ G+L Y+ EME ++ Sbjct: 79 NCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYL--RSLRPEMENNPVLAPPSLSKMIQM 136 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS--- 176 +I + Y + + VHRDL N ++ KI DFG++ + + ++ R Sbjct: 137 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 196 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207 + +PE + ++ D+WS GV+L+ + Sbjct: 197 VRWMSPESLKDGVFTTYS-DVWSFGVVLWEI 226 >2QLU-A nrPDB Length = 314 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 107/242 (44%), Gaps = 40/242 (16%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G V G L + G FG V + QL VAVKI Q +S + +REI + Sbjct: 10 GLVPRGSLQLLEIKARGRFGCV--WKAQLMNDFVAVKIFPLQDKQSW----QSEREIFST 63 Query: 69 KLFRHPHIIKLYQV----ISTPTDFFMVMEYVSGGELFDYICKH-------GRVEEMEAR 117 +H ++++ + + +++ + G L DY+ + V E +R Sbjct: 64 PGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSR 123 Query: 118 RLFQQILSAVDYC----HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FL 170 L + V +C H+ + HRD K +NVLL + + A +ADFGL+ G+ Sbjct: 124 GL-SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT 182 Query: 171 RTSCGSPNYAAPEVISGRLY----AGPEVDIWSCGVILYALL--CGT---------LPFD 215 G+ Y APEV+ G + A +D+++ G++L+ L+ C LPF+ Sbjct: 183 HGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFE 242 Query: 216 DE 217 +E Sbjct: 243 EE 244 >3LLT-A nrPDB Length = 360 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 107/237 (45%), Gaps = 47/237 (19%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQK--IRSLDVVGKIKREIQNLKLFRHPHIIKL 79 +G GTFG+V + +H AVK++ K RS + I ++IQN + + +I+K Sbjct: 43 MGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDI-NNNNIVKY 101 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHG----RVEEMEARRLFQQILSAVDYCHRHMV 135 + ++ E + G L++ I ++ +E+++ + +IL A++Y + + Sbjct: 102 HGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCI--EILKALNYLRKMSL 158 Query: 136 VHRDLKPENVLLD-------------------------AHMNAKIADFGLSNMMSD--GE 168 H DLKPEN+LLD K+ DFG + SD G Sbjct: 159 THTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGS 218 Query: 169 FLRTSCGSPNYAAPEVISGRLYAGPEV--DIWSCGVILYALLCGTLPF-DDEHVPTL 222 + T Y APEVI L G +V D+WS G +L L G+L F EH+ L Sbjct: 219 IINTR----QYRAPEVI---LNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHL 268 >3HNG-A nrPDB Length = 360 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 38/149 (25%), Positives = 73/149 (48%), Gaps = 7/149 (4%) Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGS--PN 178 Q+ +++ +HRDL N+LL + KI DFGL+ ++ + +++R Sbjct: 207 QVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLK 266 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF-KKIRGGV-FYIPE 235 + APE I ++Y+ + D+WS GV+L+ + G P+ + F ++R G+ PE Sbjct: 267 WMAPESIFDKIYS-TKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPE 325 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIRE 264 Y + +++ DP +R ++ E Sbjct: 326 YSTPEIYQIMLDCWHRDPKERPRFAELVE 354 >3SV0-A nrPDB Length = 483 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 98/216 (45%), Gaps = 19/216 (8%) Query: 12 KIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLK 69 ++G+ + LG +G G+FG++ +G + T +VA+K+ N + K L KI R +Q Sbjct: 4 RVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGT 63 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 + ++ + V M + S +LF++ + ++ L Q+++ V++ Sbjct: 64 GIPN---VRWFGVEGDYNVLVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQMINRVEF 118 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAK---IADFGLSNMMSDGEF--------LRTSCGSPN 178 H +HRD+KP+N L+ A I DFGL+ D + G+ Sbjct: 119 VHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTAR 178 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 YA+ G + D+ S G +L L G+LP+ Sbjct: 179 YASVNTHLG-IEQSRRDDLESLGYVLMYFLRGSLPW 213 >4M69-B nrPDB Length = 283 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 84/194 (43%), Gaps = 29/194 (14%) Query: 42 VAVKILNRQKIRSLDVVG-KIKREIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYV 96 V +K+ N + S+ +V EI+ +K F P+I++++ + P +F +VMEY Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 94 Query: 97 SGGELFDYICKHGRVEEMEARRLFQQILSAVD---YCHRHMVVHRDLKPENVLLDAHMNA 153 G L + + + + M R L +L A H +HR++ + L+ Sbjct: 95 ELGTLRELLDREKDLT-MSVRSLL--VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQV 151 Query: 154 KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE------------VDIWSCG 201 K+A F LS + RT+ E S +Y PE +I+S G Sbjct: 152 KLAGFELSK--TQNSISRTA----KSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFG 205 Query: 202 VILYALLCGTLPFD 215 ++L+ + G +PF+ Sbjct: 206 IVLWEIATGKIPFE 219 >2WO6-A nrPDB Length = 382 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 26/218 (11%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK---------IRSLDVV 58 +G + Y + +G G+FG+V ++ VA+KI+ +K +R L+++ Sbjct: 48 NGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELM 107 Query: 59 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEA 116 K E++ +I+ L + +V E +S L+D + V Sbjct: 108 NKHDTEMKY-------YIVHLKRHFMFRNHLCLVFEMLSYN-LYDLLRNTNFRGVSLNLT 159 Query: 117 RRLFQQILSAVDYCH--RHMVVHRDLKPENVLL--DAHMNAKIADFGLSNMMSDGEFLRT 172 R+ QQ+ +A+ + ++H DLKPEN+LL KI DFG S + G+ + Sbjct: 160 RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQ 217 Query: 173 SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG 210 S Y +PEV+ G Y +D+WS G IL + G Sbjct: 218 YIQSRFYRSPEVLLGMPY-DLAIDMWSLGCILVEMHTG 254 >3ZBF-A nrPDB Length = 322 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/271 (22%), Positives = 108/271 (39%), Gaps = 34/271 (12%) Query: 22 LGVGTFGKV---------KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 LG G FG+V +G ++ KVAVK L + + + +E + F Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEI---KVAVKTLKKGSTDQEKI--EFLKEAHLMSKFN 95 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ--------QIL 124 HP+I+K V ++++E + GG+L Y+ + R+ L I Sbjct: 96 HPNILKQLGVCLLNEPQYIILELMEGGDLLTYL-RKARMATFYGPLLTLVDLVDLCVDIS 154 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAH-----MNAKIADFGLSNMMSDGEFLRTSCGS--- 176 Y R +HRDL N L+ KI DFGL+ + ++ R Sbjct: 155 KGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLP 214 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR-GGVFYIP 234 + APE + ++ + D+WS G++++ +L G P+ + ++ GG P Sbjct: 215 VRWMAPESLMDGIFT-TQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPP 273 Query: 235 EYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 + L+ +P +R T I++ Sbjct: 274 RNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 304 >4BTF-A nrPDB Length = 469 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 84/194 (43%), Gaps = 29/194 (14%) Query: 42 VAVKILNRQKIRSLDVVG-KIKREIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYV 96 V +K+ N + S+ +V EI+ +K F P+I++++ + P +F +VMEY Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 280 Query: 97 SGGELFDYICKHGRVEEMEARRLFQQILSAVD---YCHRHMVVHRDLKPENVLLDAHMNA 153 G L + + + + M R L +L A H +HR++ + L+ Sbjct: 281 ELGTLRELLDREKDLT-MSVRSLL--VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQV 337 Query: 154 KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE------------VDIWSCG 201 K+A F LS + RT+ E S +Y PE +I+S G Sbjct: 338 KLAGFELSK--TQNSISRTA----KSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFG 391 Query: 202 VILYALLCGTLPFD 215 ++L+ + G +PF+ Sbjct: 392 IVLWEIATGKIPFE 405 >4RT7-A nrPDB Length = 415 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 40/147 (27%), Positives = 69/147 (46%), Gaps = 7/147 (4%) Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEF-LRTSCGSP-N 178 Q+ +++ VHRDL NVL+ KI DFGL+ ++MSD + +R + P Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYI--PE 235 + APE + +Y + D+WS G++L+ + G P+ V F K+ F + P Sbjct: 311 WMAPESLFEGIYT-IKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDI 262 Y + ++ D KR + ++ Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 14/97 (14%) Query: 18 LGDTLGVGTFGKV---------KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G LG G FGKV K G +VAVK+L ++K S + + Sbjct: 69 FGKVLGSGAFGKVMNATAYGISKTG----VSIQVAVKML-KEKADSSEREALMSELKMMT 123 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI 105 +L H +I+ L + +++ EY G+L +Y+ Sbjct: 124 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL 160 >4TN6-A nrPDB Length = 318 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 99/227 (43%), Gaps = 25/227 (11%) Query: 11 VKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKI-LNRQKIRSLDVVGKIKREIQNL 68 +++G+ Y LG +G G+FG + +G G +VA+K+ + K L + KI + +Q Sbjct: 3 LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG- 61 Query: 69 KLFRHPHIIKLYQVISTPTDF-FMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILS 125 I + D+ MVME + S +LF++ + ++ + L Q++S Sbjct: 62 -----GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLL--LADQMIS 114 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAK---IADFGLSNMMSDGEF--------LRTSC 174 ++Y H +HRD+KP+N L+ I DFGL+ D + Sbjct: 115 RIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT 174 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT 221 G+ YA+ G + D+ S G +L G+LP+ T Sbjct: 175 GTARYASINTHLG-IEQSRRDDLESLGYVLMYFNLGSLPWQGLKAAT 220 >5E8V-A nrPDB Length = 316 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 105/238 (44%), Gaps = 35/238 (14%) Query: 20 DTL-GVGTFGKV-KIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 DTL G G F +V K Q T + VAVKI ++ S I +I NLK H Sbjct: 14 DTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI-NLK---HE 69 Query: 75 HIIKLYQVISTPTD----FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 +I++ T+ ++++ + + G L +Y+ +H + + R+L + + + Sbjct: 70 NILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLARGIAHL 128 Query: 131 H---------RHMVVHRDLKPENVLLDAHMNAKIADFGLS-----NMMSDGEFLRTSCGS 176 H + +VHRDLK N+L+ + + DFGLS + D G+ Sbjct: 129 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 177 PNYAAPEVISG-----RLYAGPEVDIWSCGVILYALL--CGTLPFDDEHVPTLFKKIR 227 Y APEV++ + + + D++S ++L+ + C + ++ P K+R Sbjct: 189 ARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVR 246 >6BFN-A nrPDB Length = 342 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/167 (26%), Positives = 77/167 (46%), Gaps = 25/167 (14%) Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQ 122 E++ L FRHP+I+ + + +V ++ G L D + C+ + + Sbjct: 71 EVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDI 130 Query: 123 ILS---AVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGL-------------SNMM 164 +L A+ + H+ ++H D+K NVLLD + K+ DFGL S+M+ Sbjct: 131 LLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMV 190 Query: 165 SDGEFLRTSCGSPNYAAPEVI-SGRLYAGPEVDIWSCGVILYALLCG 210 + + +R G+ Y E I +GRL + D +S GV++ L G Sbjct: 191 ARTQTVR---GTLAYLPEEYIKTGRLAV--DTDTFSFGVVVLETLAG 232 >4L68-A nrPDB Length = 340 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 81/181 (44%), Gaps = 14/181 (7%) Query: 39 GHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSG 98 G +AVK L+ K+ + + E+ L RH ++ L + F+V +Y+S Sbjct: 64 GSALAVKHLSTCKLGERE----FRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSN 119 Query: 99 GELFDYI-CKHGRVEEMEARRLFQQILSAVDYCH---RHMVVHRDLKPENVLLDAHMNAK 154 G L + G ++ R+ + + H R ++H+++ +L+D +A+ Sbjct: 120 GTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDAR 179 Query: 155 IADFGLSNMM-----SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC 209 I D GL+ +M ++ F+ G Y APE S + A + D++ GV+L L Sbjct: 180 IIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLKGDVYGLGVVLLELAT 238 Query: 210 G 210 G Sbjct: 239 G 239 >3AOX-A nrPDB Length = 344 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/275 (23%), Positives = 112/275 (40%), Gaps = 32/275 (11%) Query: 22 LGVGTFGKVKIGEHQLTGH-------KVAVKILNR--QKIRSLDVVGKIKREIQNLKLFR 72 LG G FG+V E Q++G +VAVK L + LD + E + F Sbjct: 55 LGHGAFGEVY--EGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFL----MEALIISKFN 108 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-------CKHGRVEEMEARRLFQQILS 125 H +I++ V F+++E ++GG+L ++ + + ++ + + I Sbjct: 109 HQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC 168 Query: 126 AVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRT-SCG--SPNY 179 Y + +HRD+ N LL AKI DFG++ + + R C + Sbjct: 169 GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW 228 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYL 237 PE ++ + D WS GV+L+ + G +P+ + + + + GG P+ Sbjct: 229 MPPEAFMEGIFTS-KTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNC 287 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREH-EWFKQD 271 V ++ Q P R I E E+ QD Sbjct: 288 PGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQD 322 >4MWI-A nrPDB Length = 294 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/190 (22%), Positives = 85/190 (44%), Gaps = 19/190 (10%) Query: 42 VAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYV 96 VA+K+ + + S+ +V + +EI+ +K F P+I++++ + TP F +VMEY Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 97 SGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR-----HMVVHRDLKPENVLLDAHM 151 G L + + R +++ + +L A +R +H ++ N L+ Sbjct: 110 ELGTLRELL---DREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGY 166 Query: 152 NAKIADFGLSNMMSDGEFLRTS-----CGSPNYAAPEVISGRLYA-GPEVDIWSCGVILY 205 K+A F L + T S Y +P+ + Y + +I+S G++L+ Sbjct: 167 QVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLW 226 Query: 206 ALLCGTLPFD 215 + G +PF Sbjct: 227 EIATGDIPFQ 236 >4XHL-A nrPDB Length = 394 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 90/228 (39%), Gaps = 52/228 (22%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + +G +G G+FG + G + ++G +VA+++ + IRS RHP Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRL---ESIRS-----------------RHPQ 48 Query: 76 I---IKLYQVISTPTDFFMVMEYVSGGE---------------LFDYICKHGRVEEMEAR 117 + ++Y+ +S + + GE LF+Y C H R Sbjct: 49 LDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNY-C-HRRFSFKTVI 106 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK---IADFGLSNMMSDGEFLR--- 171 L Q+ + Y H +HRD+KP+N L+ + DFGLS D R Sbjct: 107 MLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP 166 Query: 172 -----TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 + G+ YA+ G + D+ S G +L G+LP+ Sbjct: 167 YRENKSLTGTARYASVNTHLG-IEQSRRDDLESLGYVLIYFCKGSLPW 213 >3REP-A nrPDB Length = 271 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/248 (22%), Positives = 109/248 (43%), Gaps = 35/248 (14%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK--IKREIQNLKLFRHPHIIKLYQVIST 85 G++ G Q G+ + VK+L K+R E L++F HP+++ + + Sbjct: 24 GELWKGRWQ--GNDIVVKVL---KVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQS 78 Query: 86 PTDFF--MVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVDYCH--RHMVVHRD 139 P ++ ++ G L++ + + V++ +A + + + + H ++ Sbjct: 79 PPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHA 138 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG---SPNYAAPEVISGRLYAGPE-- 194 L +V++D M A+I+ M+D +F S G +P + APE + + PE Sbjct: 139 LNSRSVMIDEDMTARIS-------MADVKFSFQSPGRMYAPAWVAPEALQKK----PEDT 187 Query: 195 ----VDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVATLLMHM 248 D+WS V+L+ L+ +PF D + K+ G IP ++ V+ L+ Sbjct: 188 NRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKIC 247 Query: 249 LQVDPLKR 256 + DP KR Sbjct: 248 MNEDPAKR 255 >4XHH-A nrPDB Length = 403 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 53/228 (23%), Positives = 90/228 (39%), Gaps = 52/228 (22%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + +G +G G+FG + G + ++G +VA+++ + IRS RHP Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRL---ESIRS-----------------RHPQ 48 Query: 76 I---IKLYQVISTPTDFFMVMEYVSGGE---------------LFDYICKHGRVEEMEAR 117 + ++Y+ +S + + GE LF+Y H + Sbjct: 49 LDYESRVYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC--HRKFSFKTVI 106 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK---IADFGLSNMMSDGEFLR--- 171 L Q++ V Y H +HRD+KP+N L+ + DFGLS D R Sbjct: 107 MLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP 166 Query: 172 -----TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 + G+ YA+ G + D+ S G +L G+LP+ Sbjct: 167 YRENKSLTGTARYASVNTHLG-IEQSRRDDLESLGYMLIYFCKGSLPW 213 >5CLR-A nrPDB Length = 451 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 26/58 (44%), Positives = 35/58 (60%), Gaps = 2/58 (3%) Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 V H ++HRDLKP N++LDA M + DFG S+ SD E S G+ +Y APE+ Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPEL 244 >5X18-A nrPDB Length = 295 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 51/224 (22%), Positives = 103/224 (45%), Gaps = 26/224 (11%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 HY +G +G G+FG + G + + G VA+K R+ +++ E + K+ Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKT-----EAPQLRDEYKTYKILNGT 62 Query: 74 PHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+I Y +V++ + S +LFD+ + V+ + ++ Q+++ ++ H Sbjct: 63 PNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVV--QVAVQMITLIEDLH 120 Query: 132 RHMVVHRDLKPENVLL------DAHMNAKIADFGLSNMMSDGEF--------LRTSCGSP 177 H +++RD+KP+N L+ DA+ N + DFG++ D + ++ G+ Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDAN-NIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTA 179 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT 221 Y + GR + + D+ + G + + L G LP+ P Sbjct: 180 RYMSINTHLGREQSRRD-DMEALGHVFFYFLRGHLPWQGLKAPN 222 >5FQD-C nrPDB Length = 341 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 46/174 (26%), Positives = 74/174 (42%), Gaps = 43/174 (24%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G Y L +G G+FG + + + G +VAVK L QK R H Sbjct: 19 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKAR-------------------H 58 Query: 74 PHII---KLYQVISTPTDF-------------FMVMEYV--SGGELFDYICKHGRVEEME 115 P ++ KLY+++ +VM+ + S +LF++ + R Sbjct: 59 PQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKT 116 Query: 116 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA--HMNAK-IADFGLSNMMSD 166 L Q++S ++Y H +HRD+KP+N L+ H N + DFGL+ D Sbjct: 117 VLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRD 170 >2CMW-A nrPDB Length = 310 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 102/222 (45%), Gaps = 25/222 (11%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFRHPHI 76 +G +G G FG++++G++ T VA+K+ + + L + + +++ + + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAG----EGL 59 Query: 77 IKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCHRH 133 ++Y MV+E + S +LFD +C R ++ + Q+LS ++Y H Sbjct: 60 PQVYYFGPCGKYNAMVLELLGPSLEDLFD-LCD--RTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 134 MVVHRDLKPENVLLDAHMNAK-----IADFGLSNMMSDGEFL--------RTSCGSPNYA 180 +++RD+KPEN L+ N K I DFGL+ D E ++ G+ Y Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 + G+ + + D+ + G + L G+LP+ TL Sbjct: 177 SINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTL 217 >4L00-A nrPDB Length = 304 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 100/228 (43%), Gaps = 33/228 (14%) Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-RLFQQILSA 126 ++ H HI+ LY V + MV E+V GG L ++ + V + ++ +Q+ SA Sbjct: 86 MRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASA 145 Query: 127 VDYCHRHMVVHRDLKPENVLL-----DAHMNA--KIADFGLS-NMMSDGEFLRTSCGSPN 178 + Y +VH ++ +N+LL D+ K++D G+ ++S E + Sbjct: 146 LSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI----P 201 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALL-CGTLPFDDEHVPTLFKKIRGGVFYIPEYL 237 + APE + D WS G L+ + G +P D+ TL +K R FY E Sbjct: 202 WIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDK---TLIEKER---FY--ESR 253 Query: 238 NRSV-------ATLLMHMLQVDPLK----RATIKDIREHEWFKQDLPS 274 R V A L+ + DP + RA ++DI + E D+ S Sbjct: 254 CRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVS 301 >4JRN-A nrPDB Length = 372 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 7/98 (7%) Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178 L Q + V +VH D+KP N LL + DFG + + + + G+P Sbjct: 207 LSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNS---VGRAIGTPG 263 Query: 179 YAAPE---VISGRLYAGPEVDIWSCGVILYALLCGTLP 213 Y PE +G Y P D W G+ LY + C P Sbjct: 264 YEPPERPFQATGITYTFP-TDAWQLGITLYCIWCKERP 300 >3PG1-A nrPDB Length = 362 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 16/203 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVK-ILNR-QKIRSLDVVG------KIKREIQN 67 Y + + G++G V G G VA+K + N R+++++ ++ REI+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDS-EGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 68 LKLFRHPHIIKLYQVI---STPT--DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ- 121 L F HP+I+ L + P ++V E + +L I V + + F Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFMY 141 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 IL + H VVHRDL P N+LL + + I DF L+ + Y A Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 182 PEVISGRLYAGPEVDIWSCGVIL 204 PE++ VD+WS G ++ Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVM 224 >5UV4-A nrPDB Length = 311 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 82/187 (43%), Gaps = 15/187 (8%) Query: 38 TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF--FMVMEY 95 G+ + VK L +S + REI+ L RHP+++ L P + M+ +Y Sbjct: 48 NGYMLTVKWLKEGFAKSKK---EFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDY 104 Query: 96 VSGGELFDYICKHGR-----VEEMEARRLFQQILSAVDYCHRHMVV-HRDLKPENVLL-D 148 L Y+ + + + + I +DY H V+ H ++K NVL+ + Sbjct: 105 ADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQN 164 Query: 149 AHMNAKIADFGLSNMMSDGEFLRT--SCGSPNYAAPEVIS-GRLYAGPEVDIWSCGVILY 205 + +A + D+ L +M+ + G+ Y+ PE S + + D+++ GVIL Sbjct: 165 STPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILL 224 Query: 206 ALLCGTL 212 LL G + Sbjct: 225 ELLTGKI 231 >4BTK-A nrPDB Length = 337 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 25/222 (11%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHIIKLY 80 +G G FG++ LT VA+K+ + Q+ + + +K E+ LK + H+ + Sbjct: 64 IGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV-----LKMEVAVLKKLQGKDHVCRFI 118 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 ++VM+ + G L D G RL +QIL +++ H +HR Sbjct: 119 GCGRNEKFNYVVMQ-LQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHR 177 Query: 139 DLKPENVLL----DAHMNAKIADFGL----SNMMSDGEFLRTSC---GSPNYAAPEVISG 187 D+KP N + + + DFGL +N D R G+ YA+ Sbjct: 178 DIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKN 237 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKK 225 R G D+WS +L G LP+ D E V + +K Sbjct: 238 R-EMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK 278 >4NFN-A nrPDB Length = 309 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 25/222 (11%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHIIKLY 80 +G G FG++ LT VA+K+ + Q+ + + +K E+ LK + H+ + Sbjct: 29 IGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV-----LKMEVAVLKKLQGKDHVCRFI 83 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 ++VM+ + G L D G RL +QIL +++ H +HR Sbjct: 84 GCGRNEKFNYVVMQ-LQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHR 142 Query: 139 DLKPENVLL----DAHMNAKIADFGL----SNMMSDGEFLRTSC---GSPNYAAPEVISG 187 D+KP N + + + DFGL +N D R G+ YA+ Sbjct: 143 DIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKN 202 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKK 225 R G D+WS +L G LP+ D E V + +K Sbjct: 203 R-EMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEK 243 >5USZ-A nrPDB Length = 289 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/217 (20%), Positives = 95/217 (43%), Gaps = 22/217 (10%) Query: 10 RVKIGHYVLGDTLGVGTFGKV------KIGEH-QLTGHKVAVKILNRQKIRSLDVVGKIK 62 +++ + ++LG GTF K+ ++G++ QL +V +K+L++ + + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA 63 Query: 63 REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ 121 + L H H++ Y V + +V E+V G L Y+ K+ + + + + Sbjct: 64 SMMSKLS---HKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK 120 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMN--------AKIADFGLSNMMSDGEFLRTS 173 Q+ +A+ + + ++H ++ +N+LL + K++D G+S + + L+ Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 174 CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG 210 + PE I D WS G L+ + G Sbjct: 181 IP---WVPPECIENPKNLNLATDKWSFGTTLWEICSG 214 >6EAS-A nrPDB Length = 308 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 53/244 (21%), Positives = 95/244 (38%), Gaps = 39/244 (15%) Query: 42 VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL--YQVISTPTDFFMVMEYVSGG 99 VA ++ K S + + +++I NL H + + L Y P MV EY G Sbjct: 69 VASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNG 128 Query: 100 ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM------VVHRDLKPENVLLDAHMNA 153 LF+++ H R E +I + YC HM R+ V L A Sbjct: 129 TLFEHL--HVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAA 186 Query: 154 KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD--IWSCGVILYALLCGT 211 K++D EF + G + + L P+++ + G++L +L G Sbjct: 187 KVSDL---------EFWNDAKGHNS-----TTNNELAFSPDMEDIVRKYGMVLLEILTGR 232 Query: 212 LPFDDEHVPT---LFKKIRGG----------VFYIPEYLNRSVATLLMHMLQVDPLKRAT 258 +P ++ P + + GG + + PE R++ ++ + DP KR Sbjct: 233 VPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQ 292 Query: 259 IKDI 262 +K++ Sbjct: 293 MKEV 296 >4NT4-A nrPDB Length = 312 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 102/225 (45%), Gaps = 20/225 (8%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKIL-NRQKIRSLDVVGKIKREIQNLKLFRH 73 ++ +G +G G FG++++G++ VA+K+ + K L + + + + + Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 74 PHIIKLYQVISTPTDF-FMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 I ++Y + + + MV+E + S +LF+ IC + + +Q+L ++Y Sbjct: 73 DGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFN-ICAR-KFSLKTVLMIAKQLLHRIEYV 130 Query: 131 HRHMVVHRDLKPENVLLDAHMNAK-----IADFGLSNMMSDGEFLR--------TSCGSP 177 H +++RD+KPEN L+ + I DFGL+ D + R + G+ Sbjct: 131 HSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTA 190 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 Y + GR + + D+ + G + L G+LP+ TL Sbjct: 191 RYMSINTHMGREQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTL 234 >6J6I-B nrPDB Length = 351 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 7/99 (7%) Query: 118 RLFQQILSAVDYCHR---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LR 171 ++ ++I +AV Y H +++HRD+KP +V LD + AK++D S + +G+ Sbjct: 167 KIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAE 226 Query: 172 TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG 210 G+ Y P + + D++S G+ L ++ G Sbjct: 227 WVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITG 264 >2CHL-A nrPDB Length = 351 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/224 (24%), Positives = 101/224 (45%), Gaps = 24/224 (10%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 ++ +G +G G FG++++G++ T VA+K L K R+ + + + Q L Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRAPQLHLEYRFYKQ---LGSGD 86 Query: 75 HIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYCH 131 I ++Y MV+E + S +LFD +C R ++ + Q++S ++Y H Sbjct: 87 GIPQVYYFGPCGKYNAMVLELLGPSLEDLFD-LCD--RTFSLKTVLMIAIQLISRMEYVH 143 Query: 132 RHMVVHRDLKPENVLLDAHMNAK-----IADFGLSNMMSDGEFL--------RTSCGSPN 178 +++RD+KPEN L+ N I DF L+ D E ++ G+ Sbjct: 144 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTAR 203 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 Y + G+ + + D+ + G + L G+LP+ TL Sbjct: 204 YMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTL 246 >5OAT-A nrPDB Length = 411 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 16/140 (11%) Query: 133 HMVVHRDLKPENVLLDAHMNAK----IADFG--LSNMMSDGEFLRTS-----CGSPNYAA 181 H + HRDLK +N+LLD I+DFG L++ + TS G+ A Sbjct: 172 HGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMA 231 Query: 182 PEVISGR-----LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY 236 PE+I + + + D+W+ G I Y + PF F G + +P+ Sbjct: 232 PEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDE 291 Query: 237 LNRSVATLLMHMLQVDPLKR 256 + + L+ ++L+ +P KR Sbjct: 292 VPTVIQALVANLLKRNPNKR 311 >4I94-A nrPDB Length = 300 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/185 (24%), Positives = 81/185 (43%), Gaps = 20/185 (10%) Query: 41 KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE 100 ++AVK NR +S + E + + R+ + L + ++ E++ Sbjct: 55 RIAVKRFNR---KSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLLIAEFMPNET 111 Query: 101 LFDYICKHGRVEEMEAR---RLFQQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIA 156 L ++ H + M+ R+ I A++YC + ++ DL VL D N +++ Sbjct: 112 LAKHLF-HWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFDDDANPRLS 170 Query: 157 DFGLSNMMSDGEFLRTSCGSPNYAAPEVI-SGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 FGL DG+ T+ + PE + +GR+ PE I+S G +L LL G Sbjct: 171 CFGLMKNSRDGKSYSTNLA---FTPPEYLRTGRV--TPESVIYSFGTLLLDLLSG----- 220 Query: 216 DEHVP 220 +H+P Sbjct: 221 -KHIP 224 >2C47-A nrPDB Length = 313 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/225 (21%), Positives = 103/225 (45%), Gaps = 26/225 (11%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFRH 73 ++ +G +G G FG++++G++ T VA+K+ + + L + + +++ + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATE---- 60 Query: 74 PHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQ-QILSAVDYC 130 + ++Y MV+E + S +LFD +C R ++ + Q+++ ++Y Sbjct: 61 -GVPQVYYFGPCGKYNAMVLELLGPSLEDLFD-LCD--RTFTLKTVLMIAIQLITRMEYV 116 Query: 131 HRHMVVHRDLKPENVLLDAHMNAK-----IADFGLSNMMSDGEFL--------RTSCGSP 177 H +++RD+KPEN L+ + I DFGL+ D E ++ G+ Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 176 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 Y + G+ + + D+ + G + L G+LP+ TL Sbjct: 177 RYMSINTHLGKEQSRRD-DLEALGHMFMYFLRGSLPWQGLKADTL 220 >3DZO-A nrPDB Length = 413 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/109 (22%), Positives = 49/109 (44%), Gaps = 12/109 (11%) Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP 177 +L Q++ + H + +VH L+P +++LD + G +++ DG + G Sbjct: 215 QLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGASAVSPIGR- 271 Query: 178 NYAAPEVISGRLYAGPE---------VDIWSCGVILYALLCGTLPFDDE 217 +A PE + R+ + D W+ G+ +Y + C LP D+ Sbjct: 272 GFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDD 320 >4AZV-A nrPDB Length = 569 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 3/70 (4%) Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 ++VME + G L D + EE++ ++ +L ++ + H D++P NV++DA Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 150 HMNAKIADFG 159 +A++ DFG Sbjct: 375 RQHARLIDFG 384 >1CSN-A nrPDB Length = 298 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 94/216 (43%), Gaps = 24/216 (11%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 HY +G +G G+FG + G + L +VA+K R+ +++ E + KL Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR-----SDAPQLRDEYRTYKLLAGC 65 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL-FQQILSAVDYCHR 132 I +Y +V++ + G L D + GR ++ + +Q+L+ V H Sbjct: 66 TGIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHE 124 Query: 133 HMVVHRDLKPENVLL------DAHMNAKIADFGLSNMMSDG--------EFLRTSCGSPN 178 +V+RD+KP+N L+ +A+M + DFG+ D + G+ Sbjct: 125 KSLVYRDIKPDNFLIGRPNSKNANM-IYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTAR 183 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 214 Y + GR + + D+ + G + L G+LP+ Sbjct: 184 YMSINTHLGREQSRRD-DLEALGHVFMYFLRGSLPW 218 >4O1O-A nrPDB Length = 717 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 28/50 (56%) Query: 112 EEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS 161 E+ AR + + A+ HR H+DL+P+N+L+D+ +ADF S Sbjct: 440 EDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKS 489 >4AZW-A nrPDB Length = 471 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 3/70 (4%) Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 ++VME + G L D + EE++ ++ +L ++ + H D++P NV++DA Sbjct: 318 WLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDA 374 Query: 150 HMNAKIADFG 159 +A++ DFG Sbjct: 375 RQHARLIDFG 384 >4CI6-B nrPDB Length = 643 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 44/191 (23%), Positives = 84/191 (43%), Gaps = 38/191 (19%) Query: 57 VVGKIKREIQNLKLF--------------RHPHIIKLYQVISTPTD----FFMVMEYVSG 98 +V KI+R I LF +HP++ ++ + P + ++M+ V G Sbjct: 71 LVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDEVDG 130 Query: 99 GELFDYI------CKHGRVEEMEA-----RRLFQQILSAVDYCHRHMVVHRDLKPENVLL 147 D + K G++ EA + + ++L ++ + +VH D+KP NV+ Sbjct: 131 WRCSDTLRSLADSWKQGKINS-EAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVF 189 Query: 148 D-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYA 206 D A + D GL + GE + + ++ APE+ G L A + D++ +++ Sbjct: 190 DRASGEPVVIDLGLHS--RSGE--QPKGFTESFKAPELGVGNLGASEKSDVF---LVVST 242 Query: 207 LLCGTLPFDDE 217 LL G F+ + Sbjct: 243 LLHGIEGFEKD 253 >4WUA-A nrPDB Length = 401 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 24/32 (75%), Gaps = 1/32 (3%) Query: 117 RRLFQQILSAVDYCH-RHMVVHRDLKPENVLL 147 +++ QQ+L +DY H + ++H D+KPEN+LL Sbjct: 153 KKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 184 >2W1Z-A nrPDB Length = 368 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/128 (21%), Positives = 51/128 (39%), Gaps = 12/128 (9%) Query: 95 YVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK 154 ++ G L + H + +L Q++ + +VH D + N+LLD Sbjct: 172 HILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVF 231 Query: 155 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE---------VDIWSCGVILY 205 + G +++ DG + G +A PE + R+ + D W+ G+ +Y Sbjct: 232 LT--GFEHLVRDGASAVSPIGR-GFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIY 288 Query: 206 ALLCGTLP 213 + C LP Sbjct: 289 WIWCADLP 296 >6G4J-A nrPDB Length = 315 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 41/149 (27%), Positives = 62/149 (41%), Gaps = 23/149 (15%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ Y L LG G G V + E GH VA+K+ S D + I E+ L Sbjct: 21 GKWNGNTYTLRKQLGKGANGIVYLAETS-DGH-VALKV-------SDDSLS-ITSEVNVL 70 Query: 69 KLFRHPHIIKL----------YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR 118 K F + + Y + F MEY+ G L Y+ G E + Sbjct: 71 KSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKG-AEWIPV-- 127 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLL 147 L Q+LS++ H+ + DLKP+N+++ Sbjct: 128 LMIQLLSSLSVLHQQGWIFGDLKPDNLIV 156 >3BYV-A nrPDB Length = 377 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 23/102 (22%), Positives = 46/102 (45%), Gaps = 13/102 (12%) Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 Q++ + H + +VH L+P +++LD + G +++ DG + +S S + Sbjct: 214 QVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGARVVSSV-SRGFEP 270 Query: 182 PEVISGRLYAGP----------EVDIWSCGVILYALLCGTLP 213 PE+ + R D W+ G+++Y + C LP Sbjct: 271 PELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLP 312 >6EQI-C nrPDB Length = 433 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 63/149 (42%), Gaps = 18/149 (12%) Query: 126 AVDYCHRHMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFL-------RTS 173 AV + + H + HRDLK +N+L+ DA+ I DFG + + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 174 CGSPNYAAPEVISGR-----LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIR- 227 G+ APE+ + + + D+W+ G I Y + PF D+ + L K + Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKE 298 Query: 228 GGVFYIPEYLNRSVATLLMHMLQVDPLKR 256 + +P+ + + L+ +ML KR Sbjct: 299 EDLPELPDTIPFIIRNLVSNMLSRSTNKR 327 >5UU1-A nrPDB Length = 324 Score = 35.0 bits (79), Expect = 0.089, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 40/74 (54%), Gaps = 3/74 (4%) Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 FMVME + G +L ++G ++ +L ++L ++Y H + VH D+K N+LL Sbjct: 107 FMVMERL-GIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 165 Query: 150 HM--NAKIADFGLS 161 +AD+GLS Sbjct: 166 KNPDQVYLADYGLS 179 >2RSV-A nrPDB Length = 403 Score = 35.0 bits (79), Expect = 0.089, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 53/145 (36%), Gaps = 27/145 (18%) Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 FM+M+ Y R +L +IL ++Y H H VH D+K N+LL+ Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 150 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 ++ D+GL+ DG TS + N AP Sbjct: 195 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 249 Query: 192 GPEVDIWSCGVILYALLCGTLPFDD 216 D+ G + L G LP++D Sbjct: 250 ----DLEILGYCMIQWLTGHLPWED 270 >4OAU-C nrPDB Length = 699 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 28/51 (54%), Gaps = 1/51 (1%) Query: 112 EEMEARRLFQQILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLS 161 E+ AR + I AV H H+DL+P+N+L+D+ A +ADF S Sbjct: 437 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKS 487 >2LAV-A nrPDB Length = 361 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 53/145 (36%), Gaps = 27/145 (18%) Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 FM+M+ Y R +L +IL ++Y H H VH D+K N+LL+ Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 150 HMNAKI--ADFGLS----------------NMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 ++ D+GL+ DG TS + N AP Sbjct: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRG----- 242 Query: 192 GPEVDIWSCGVILYALLCGTLPFDD 216 D+ G + L G LP++D Sbjct: 243 ----DLEILGYCMIQWLTGHLPWED 263 >5C01-A nrPDB Length = 342 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 79/202 (39%), Gaps = 18/202 (8%) Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCH 131 H H+ ++ V + MV EYV G L ++ + G V + QQ+ SA+ Y Sbjct: 138 HTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLE 197 Query: 132 RHMVVHRDLKPENVLLDAHMNA-------KIAD--FGLSNMMSDGEFLRTSCGSPNYAAP 182 +VH ++ N+LL A K++D GL + + R + AP Sbjct: 198 NKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP-----WLAP 252 Query: 183 EVISGRLYA-GPEVDIWSCGVILYAL-LCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 E + G + +D W G L + G P P+ + +PE Sbjct: 253 ECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRS-PSEKEHFYQRQHRLPEPSCPQ 311 Query: 241 VATLLMHMLQVDPLKRATIKDI 262 +ATL L +P +R + + I Sbjct: 312 LATLTSQCLTYEPTQRPSFRTI 333 >4WOV-A nrPDB Length = 317 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 79/202 (39%), Gaps = 18/202 (8%) Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCH 131 H H+ ++ V + MV EYV G L ++ + G V + QQ+ SA+ Y Sbjct: 115 HTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLE 174 Query: 132 RHMVVHRDLKPENVLLDAHMNA-------KIAD--FGLSNMMSDGEFLRTSCGSPNYAAP 182 +VH ++ N+LL A K++D GL + + R + AP Sbjct: 175 NKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP-----WLAP 229 Query: 183 EVISGRLYA-GPEVDIWSCGVILYAL-LCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 E + G + +D W G L + G P P+ + +PE Sbjct: 230 ECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRS-PSEKEHFYQRQHRLPEPSCPQ 288 Query: 241 VATLLMHMLQVDPLKRATIKDI 262 +ATL L +P +R + + I Sbjct: 289 LATLTSQCLTYEPTQRPSFRTI 310 >2X7G-A nrPDB Length = 389 Score = 33.5 bits (75), Expect = 0.28, Method: Compositional matrix adjust. Identities = 33/147 (22%), Positives = 54/147 (36%), Gaps = 51/147 (34%) Query: 117 RRLFQQILSAVDYCH-RHMVVHRDLKPENVLL---DAH---------------------- 150 + + +Q+L +DY H + ++H D+KPEN+L+ DA+ Sbjct: 143 KSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGS 202 Query: 151 ----------------------MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 + KIAD G N + + Y + EV+ G Sbjct: 203 AVSTAPAADLLVNPLDPRNADKIRVKIADLG--NACWVHKHFTEDIQTRQYRSIEVLIGA 260 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFD 215 Y+ P DIWS + + L G F+ Sbjct: 261 GYSTP-ADIWSTACMAFELATGDYLFE 286 >6BHC-A nrPDB Length = 438 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 90/213 (42%), Gaps = 44/213 (20%) Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL---FQQILSAVDYCHRHMVVHR 138 VI+ V ++V D + +HG+ ++ R++ Q+ S +++ + V H Sbjct: 148 VITREVPCLTVADFVR-----DSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHC 202 Query: 139 DLKPENVLLDAHMNAKIAD-FG---------------LSNM--------MSDGEFLRTSC 174 DL+ EN+LL + A FG +SN + D E LR Sbjct: 203 DLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQ- 261 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK--IRGGVFY 232 + APE+I+ Y + D + G+++Y +L PFD+ P L ++ R + Sbjct: 262 ---SRLAPEIITATQYK--KCDEFQTGILIYEMLHLPNPFDEN--PELKEREYTRADLPR 314 Query: 233 IP--EYLNRSVATLLMHMLQVDPLKRATIKDIR 263 IP +R + L +L +P +R I D + Sbjct: 315 IPFRSPYSRGLQQLASCLLNPNPSERILISDAK 347 >5DMZ-A nrPDB Length = 365 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 21/104 (20%), Positives = 43/104 (41%), Gaps = 15/104 (14%) Query: 122 QILSAVDYCHRHMVVHRDLKPENVLL-----------DAHMNAKIADFGLS---NMMSDG 167 ++L ++ H ++H D+KP+N +L D + D G S + G Sbjct: 180 RMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKG 239 Query: 168 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGT 211 C + + E++S + + ++D + +Y +L GT Sbjct: 240 TIFTAKCETSGFQCVEMLSNKPW-NYQIDYFGVAATVYCMLFGT 282 >1QTR-A nrPDB Length = 317 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 8/66 (12%) Query: 258 TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQ 317 T++ R H W+ QD S FPE +++ D+ K+V + L S DPQ Sbjct: 140 TLRKQRLH-WYYQDGASRFFPEKWERVLSILSDDERKDVIAAYR-------QRLTSADPQ 191 Query: 318 DQLAVA 323 QL A Sbjct: 192 VQLEAA 197 >6EWX-A nrPDB Length = 484 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 29/55 (52%), Gaps = 4/55 (7%) Query: 103 DYICKHGRVEEMEARR---LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK 154 D + H E+ RR L Q+ + +++ H ++HRDL EN+LL H N + Sbjct: 196 DSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL-VHCNPQ 249 >2R2Q-A nrPDB Length = 110 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 1/54 (1%) Query: 364 KPHPERMPPLIADSPKARCP-LDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIM 416 K +P+R+P ++ +PKAR P LD P L V + + + R +P D + Sbjct: 22 KKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDAL 75 >1EIF-A nrPDB Length = 135 Score = 30.0 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 24/91 (26%) Query: 4 KQKHDGRVKIGHYVLGD-----------------------TLGVGTFGKVKIGEHQLTGH 40 KQ + G +K+G YV+ D +G+G F KVK T Sbjct: 8 KQVNVGSLKVGQYVMIDGVPCEIVDISVSKPGKHGGAKARVVGIGIFEKVKKEFVAPTSS 67 Query: 41 KVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 KV V I++R+K + L ++G + +I +L+ + Sbjct: 68 KVEVPIIDRRKGQVLAIMGDMV-QIMDLQTY 97 >5LXH-A nrPDB Length = 123 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 1/54 (1%) Query: 364 KPHPERMPPLIADSPKARCP-LDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIM 416 K +P+R+P ++ +PKAR P LD P L V + + + R +P D + Sbjct: 29 KKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDAL 82 >2JII-A nrPDB Length = 352 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 50/104 (48%), Gaps = 9/104 (8%) Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKI--ADFGLS-NMMSDGEFLRTSCG--S 176 ++L A+++ H + VH ++ EN+ +D +++ A +G + G+ + G S Sbjct: 167 RLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRS 226 Query: 177 PNYAAPEVISGRLY--AGP--EVDIWSCGVILYALLCGTLPFDD 216 P+ E IS L+ GP D+ S G + L G LP+ + Sbjct: 227 PHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTN 270 >3BGY-A nrPDB Length = 237 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 13/52 (25%), Positives = 27/52 (51%), Gaps = 1/52 (1%) Query: 274 SYLFPEDPSYDANVIDDEAVKEVCEKF-ECTESEVMNSLYSGDPQDQLAVAY 324 S +FP+ Y ++ + E + E KF + + +++ + S DP D + + Y Sbjct: 75 SLIFPDKNVYRVSLFNQEQIGEFITKFSKASSNDISRYIVSLDPSDDIEIVY 126 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4CFF-A nrPDB 871 0.0 5EZV-A nrPDB 862 0.0 4REW-A nrPDB 832 0.0 4CFH-A nrPDB 727 0.0 4RED-A nrPDB 500 e-142 2YZA-A nrPDB 430 e-121 6C9D-A nrPDB 408 e-114 3H4J-B nrPDB 400 e-112 4D28-A nrPDB 399 e-111 3MN3-A nrPDB 371 e-103 4CZT-A nrPDB 367 e-102 5ES1-A nrPDB 367 e-102 5KZ7-A nrPDB 365 e-101 2QNJ-A nrPDB 361 e-100 5JN2-A nrPDB 360 e-100 2HAK-A nrPDB 343 1e-94 3NCG-A nrPDB 335 4e-92 5YKS-A nrPDB 334 8e-92 4YZB-A nrPDB 329 2e-90 4MVF-A nrPDB 329 2e-90 3LIJ-A nrPDB 326 2e-89 4CQG-A nrPDB 324 4e-89 3HZT-A nrPDB 324 5e-89 4D2V-A nrPDB 324 7e-89 5KCV-A nrPDB 322 2e-88 4YNZ-A nrPDB 321 3e-88 3MA6-A nrPDB 321 4e-88 3MV5-A nrPDB 321 6e-88 4RGJ-A nrPDB 319 1e-87 3DXN-A nrPDB 318 5e-87 5WAX-A nrPDB 317 6e-87 2JDO-A nrPDB 317 9e-87 3Q5I-A nrPDB 317 1e-86 3DFA-A nrPDB 316 2e-86 3HDN-A nrPDB 316 2e-86 5FG8-A nrPDB 312 2e-85 5IG1-A nrPDB 309 1e-84 4FG9-A nrPDB 309 2e-84 2VN9-A nrPDB 309 2e-84 1FOT-A nrPDB 308 3e-84 2BDW-A nrPDB 308 3e-84 3ZUT-A nrPDB 308 4e-84 3KK8-A nrPDB 308 4e-84 3UC3-A nrPDB 307 6e-84 3UDB-A nrPDB 307 8e-84 2JC6-A nrPDB 307 9e-84 3TXO-A nrPDB 306 2e-83 3BHH-A nrPDB 305 4e-83 2VZ6-A nrPDB 303 1e-82 5U6Y-A nrPDB 303 1e-82 2V7O-A nrPDB 302 2e-82 4UZD-A nrPDB 302 3e-82 3D2K-A nrPDB 301 5e-82 3F3Z-A nrPDB 301 6e-82 5F9E-A nrPDB 299 2e-81 4L42-A nrPDB 299 2e-81 4RA4-A nrPDB 299 3e-81 3SOA-A nrPDB 296 2e-80 4JXF-A nrPDB 295 3e-80 5XZW-A nrPDB 294 7e-80 5D9K-A nrPDB 294 8e-80 4RLP-A nrPDB 294 9e-80 4CSV-A nrPDB 293 1e-79 2W4O-A nrPDB 293 1e-79 2JAM-A nrPDB 293 1e-79 2J90-A nrPDB 291 4e-79 5FET-A nrPDB 291 8e-79 2YCR-A nrPDB 290 1e-78 1PHK-A nrPDB 289 2e-78 3I6U-A nrPDB 288 4e-78 2Z7Q-A nrPDB 288 4e-78 3PFQ-A nrPDB 288 5e-78 5N23-A nrPDB 288 6e-78 5DYK-A nrPDB 288 6e-78 3DB8-A nrPDB 288 6e-78 3COM-A nrPDB 288 6e-78 2I0E-A nrPDB 288 7e-78 5X3F-B nrPDB 287 9e-78 6E9W-A nrPDB 286 1e-77 4WB7-A nrPDB 286 2e-77 4PDS-A nrPDB 286 2e-77 5JZN-A nrPDB 285 3e-77 4B6L-A nrPDB 285 3e-77 4B8L-A nrPDB 285 4e-77 6CMJ-A nrPDB 285 4e-77 1VZO-A nrPDB 285 4e-77 5LOH-A nrPDB 285 4e-77 4LG4-A nrPDB 284 5e-77 2BPM-A nrPDB 284 6e-77 6FDY-U nrPDB 283 1e-76 4I6B-A nrPDB 283 2e-76 6ED6-A nrPDB 282 2e-76 2YAB-A nrPDB 282 3e-76 2OU7-A nrPDB 282 4e-76 4NIF-A nrPDB 281 4e-76 3GUB-A nrPDB 281 4e-76 3ORZ-A nrPDB 281 4e-76 2Y7J-A nrPDB 281 5e-76 6AO5-A nrPDB 281 5e-76 4J52-A nrPDB 281 6e-76 2A27-A nrPDB 279 2e-75 1ZWS-A nrPDB 279 2e-75 4QMW-A nrPDB 277 7e-75 6FD3-A nrPDB 277 1e-74 5YV8-A nrPDB 276 1e-74 2Y8Q-A nrPDB 276 2e-74 3TAC-A nrPDB 276 2e-74 3IS5-A nrPDB 276 2e-74 3A8W-A nrPDB 275 3e-74 4AF3-A nrPDB 275 3e-74 4JG6-A nrPDB 274 5e-74 6BDL-A nrPDB 274 6e-74 6DTL-A nrPDB 273 1e-73 2XIK-A nrPDB 272 2e-73 3DAK-A nrPDB 272 2e-73 4FZF-B nrPDB 271 4e-73 4AGU-A nrPDB 270 1e-72 2FO0-A nrPDB 269 2e-72 1NY3-A nrPDB 269 2e-72 3NIZ-A nrPDB 269 3e-72 4KS7-A nrPDB 268 3e-72 2OZA-A nrPDB 268 3e-72 3KA0-A nrPDB 268 4e-72 4AW2-A nrPDB 268 4e-72 6NPU-A nrPDB 268 4e-72 4XEY-B nrPDB 268 4e-72 2XYN-A nrPDB 268 5e-72 1CM8-A nrPDB 268 5e-72 3TKU-A nrPDB 267 6e-72 2H8H-A nrPDB 267 6e-72 3UTO-A nrPDB 267 7e-72 3OHT-A nrPDB 267 7e-72 2F57-A nrPDB 267 9e-72 3Q53-A nrPDB 267 1e-71 5DBX-A nrPDB 267 1e-71 4BBM-A nrPDB 266 2e-71 6F3F-A nrPDB 266 3e-71 4C0T-A nrPDB 266 3e-71 2X4F-A nrPDB 265 3e-71 2HW6-A nrPDB 265 3e-71 3PPZ-A nrPDB 265 3e-71 4JDH-A nrPDB 265 4e-71 2Q0N-A nrPDB 265 4e-71 5AWM-A nrPDB 265 4e-71 4EWQ-A nrPDB 265 4e-71 1KOA-A nrPDB 265 4e-71 4FR4-A nrPDB 265 5e-71 5SYS-A nrPDB 264 5e-71 2DQ7-X nrPDB 264 5e-71 4XBR-A nrPDB 264 5e-71 1KOB-A nrPDB 264 7e-71 4APC-A nrPDB 264 8e-71 5J5T-A nrPDB 264 8e-71 4FIE-A nrPDB 264 8e-71 3V5Q-A nrPDB 264 9e-71 6GU6-A nrPDB 263 1e-70 3KN6-A nrPDB 263 1e-70 3FXW-A nrPDB 263 1e-70 4WNO-A nrPDB 263 2e-70 5VO2-A nrPDB 261 4e-70 6QAU-A nrPDB 261 7e-70 4EBW-A nrPDB 260 9e-70 3ZDU-A nrPDB 260 1e-69 4AU8-A nrPDB 260 1e-69 5H2U-A nrPDB 260 1e-69 1V0B-A nrPDB 259 2e-69 4AT3-A nrPDB 259 2e-69 2WTK-C nrPDB 259 2e-69 2VD5-A nrPDB 259 2e-69 3NYO-A nrPDB 259 3e-69 3GC9-A nrPDB 259 3e-69 4E93-A nrPDB 258 4e-69 4KRC-A nrPDB 258 5e-69 1JNK-A nrPDB 257 7e-69 3E7O-A nrPDB 257 8e-69 4IC8-A nrPDB 257 8e-69 3BBT-B nrPDB 257 1e-68 5UUU-A nrPDB 256 1e-68 5EFQ-A nrPDB 256 1e-68 4ZSG-A nrPDB 256 2e-68 3OZ6-A nrPDB 256 2e-68 2J0K-A nrPDB 256 2e-68 4MYG-A nrPDB 256 2e-68 2BRG-A nrPDB 256 2e-68 5D7A-A nrPDB 256 2e-68 4UY9-A nrPDB 256 3e-68 3PVW-A nrPDB 256 3e-68 3TT0-A nrPDB 255 4e-68 4OTD-A nrPDB 254 6e-68 2UV2-A nrPDB 254 7e-68 4P5Q-A nrPDB 254 8e-68 6HXF-B nrPDB 254 8e-68 2WQN-A nrPDB 254 9e-68 6BXI-A nrPDB 254 9e-68 4TNB-A nrPDB 254 9e-68 5KMM-A nrPDB 254 9e-68 3DKO-A nrPDB 254 1e-67 4XCU-A nrPDB 254 1e-67 2F9G-A nrPDB 253 1e-67 4X7Q-B nrPDB 253 1e-67 3SXS-A nrPDB 253 2e-67 1JPA-A nrPDB 253 2e-67 2R2P-A nrPDB 253 2e-67 3GQL-A nrPDB 253 2e-67 3DTC-A nrPDB 252 2e-67 6CKI-A nrPDB 252 2e-67 6CCF-A nrPDB 252 2e-67 5MJB-A nrPDB 252 2e-67 2Y6O-A nrPDB 252 3e-67 4UYA-A nrPDB 252 4e-67 2PL0-A nrPDB 251 5e-67 5X5O-A nrPDB 251 5e-67 5A46-A nrPDB 251 6e-67 4NST-A nrPDB 251 6e-67 3HKO-A nrPDB 251 8e-67 4QNY-A nrPDB 251 9e-67 2XS0-A nrPDB 250 2e-66 4GS6-A nrPDB 249 2e-66 5NGU-A nrPDB 249 2e-66 2XNP-A nrPDB 249 3e-66 3LM0-A nrPDB 249 3e-66 4CRS-A nrPDB 249 3e-66 6GQK-A nrPDB 249 3e-66 3A4O-X nrPDB 249 3e-66 4QTB-A nrPDB 248 4e-66 3BGP-A nrPDB 247 6e-66 5O2C-A nrPDB 247 8e-66 1K9A-A nrPDB 247 8e-66 3DLS-A nrPDB 247 9e-66 4RC3-A nrPDB 247 1e-65 6CQF-A nrPDB 246 1e-65 3C51-A nrPDB 246 1e-65 4AN9-A nrPDB 246 2e-65 2HK5-A nrPDB 246 2e-65 3FI2-A nrPDB 246 2e-65 1BYG-A nrPDB 246 2e-65 1FVR-A nrPDB 246 2e-65 2PSQ-A nrPDB 246 2e-65 5L6P-A nrPDB 246 2e-65 3QGY-A nrPDB 246 2e-65 1G3N-A nrPDB 246 2e-65 6E4F-A nrPDB 246 3e-65 5TUR-A nrPDB 245 3e-65 1U5R-A nrPDB 245 3e-65 2VWV-A nrPDB 245 4e-65 6E2O-A nrPDB 245 4e-65 2GCD-A nrPDB 244 6e-65 4PDO-A nrPDB 244 7e-65 5Z33-A nrPDB 244 7e-65 5G6V-A nrPDB 244 8e-65 4H1J-A nrPDB 244 1e-64 4K33-A nrPDB 244 1e-64 4BGQ-A nrPDB 243 1e-64 1UA2-A nrPDB 242 2e-64 4XLV-A nrPDB 242 2e-64 4U41-A nrPDB 242 3e-64 5AMN-A nrPDB 242 3e-64 5EG3-A nrPDB 242 3e-64 4XI2-A nrPDB 242 4e-64 3KUL-B nrPDB 241 4e-64 5O2B-A nrPDB 241 5e-64 4EQM-A nrPDB 241 6e-64 4HZS-A nrPDB 241 7e-64 3BEA-A nrPDB 241 8e-64 6FEX-A nrPDB 241 8e-64 4LQP-A nrPDB 240 1e-63 2OGV-A nrPDB 240 1e-63 4Y93-A nrPDB 240 1e-63 5U6B-A nrPDB 240 1e-63 1U54-B nrPDB 240 1e-63 3QUP-A nrPDB 240 2e-63 4YHJ-A nrPDB 239 2e-63 3MIA-A nrPDB 239 2e-63 1AD5-A nrPDB 239 3e-63 3KRL-A nrPDB 239 3e-63 4XUF-A nrPDB 238 4e-63 6BSD-A nrPDB 238 4e-63 4PWN-A nrPDB 238 6e-63 3GC0-A nrPDB 237 7e-63 3G0E-A nrPDB 237 9e-63 1LUF-A nrPDB 237 1e-62 5HLW-A nrPDB 237 1e-62 3PP0-A nrPDB 237 1e-62 5X02-A nrPDB 237 1e-62 3M42-A nrPDB 236 1e-62 3LZB-A nrPDB 236 1e-62 5GNK-A nrPDB 236 2e-62 4O2Z-A nrPDB 236 2e-62 3CJF-A nrPDB 236 3e-62 4R7H-A nrPDB 236 3e-62 5FM2-A nrPDB 235 3e-62 5GRN-A nrPDB 235 4e-62 3C1X-A nrPDB 233 1e-61 2W96-B nrPDB 233 2e-61 1TKI-A nrPDB 232 2e-61 3ZBF-A nrPDB 232 3e-61 3I81-A nrPDB 232 3e-61 5KKR-C nrPDB 232 3e-61 3EQC-A nrPDB 232 4e-61 5HIE-A nrPDB 231 6e-61 5HI2-A nrPDB 231 6e-61 6FER-A nrPDB 231 7e-61 6DBM-A nrPDB 230 8e-61 2W1I-A nrPDB 230 9e-61 3IO7-A nrPDB 229 2e-60 4LRM-A nrPDB 229 2e-60 3ORP-A nrPDB 229 3e-60 4OLI-A nrPDB 228 4e-60 6DBN-A nrPDB 228 6e-60 4YFF-A nrPDB 228 6e-60 1U59-A nrPDB 227 7e-60 5U6C-A nrPDB 227 1e-59 1ZXE-A nrPDB 227 1e-59 4E20-A nrPDB 227 1e-59 5HVK-A nrPDB 226 2e-59 3PLS-A nrPDB 226 2e-59 3OMV-A nrPDB 225 4e-59 2OZO-A nrPDB 224 6e-59 3VN9-A nrPDB 224 1e-58 4NEU-A nrPDB 223 1e-58 3FME-A nrPDB 223 2e-58 5WNO-A nrPDB 223 2e-58 3AOX-A nrPDB 222 2e-58 3N9X-A nrPDB 222 3e-58 2I6L-A nrPDB 221 6e-58 1S9I-A nrPDB 221 7e-58 3ALO-A nrPDB 220 8e-58 6GVJ-A nrPDB 220 1e-57 4TPT-A nrPDB 219 2e-57 4HVI-A nrPDB 217 7e-57 5Y86-A nrPDB 217 8e-57 4OW8-A nrPDB 217 8e-57 3HMP-A nrPDB 217 8e-57 4X3F-A nrPDB 217 8e-57 6B2Q-A nrPDB 217 9e-57 5AP3-A nrPDB 216 1e-56 5UIU-A nrPDB 216 2e-56 3ZZW-A nrPDB 215 3e-56 5AIR-A nrPDB 215 3e-56 3PG1-A nrPDB 215 4e-56 2ZMD-A nrPDB 215 4e-56 3NIE-A nrPDB 214 7e-56 4E7W-A nrPDB 214 8e-56 4F0G-A nrPDB 214 9e-56 5B2L-A nrPDB 214 1e-55 5O0Y-A nrPDB 212 2e-55 3QA8-A nrPDB 212 3e-55 4IDT-A nrPDB 212 3e-55 4FL3-A nrPDB 212 4e-55 6CTH-A nrPDB 211 5e-55 3E3P-A nrPDB 211 6e-55 3LMG-A nrPDB 210 1e-54 5TQX-A nrPDB 210 1e-54 5TOS-A nrPDB 210 1e-54 5C26-A nrPDB 210 2e-54 4KIK-B nrPDB 210 2e-54 4Y83-A nrPDB 209 2e-54 2A1A-B nrPDB 209 4e-54 4M7I-A nrPDB 206 2e-53 5WNL-A nrPDB 206 2e-53 5X8I-B nrPDB 205 4e-53 3EB0-A nrPDB 205 6e-53 3UIU-A nrPDB 204 1e-52 5CEK-A nrPDB 203 1e-52 6DC0-A nrPDB 203 2e-52 2WTK-B nrPDB 201 5e-52 6O6Q-A nrPDB 201 6e-52 3RP9-A nrPDB 201 7e-52 5LPZ-A nrPDB 200 8e-52 5LPV-A nrPDB 200 8e-52 4G3E-A nrPDB 200 1e-51 5VD3-A nrPDB 199 2e-51 3MY0-A nrPDB 199 3e-51 3Q4U-A nrPDB 199 3e-51 2BUJ-A nrPDB 198 4e-51 6FYV-A nrPDB 198 6e-51 6J5U-C nrPDB 197 1e-50 4C59-A nrPDB 195 4e-50 2PMN-X nrPDB 195 4e-50 5ZTN-A nrPDB 194 1e-49 4EUU-A nrPDB 193 2e-49 4JLC-A nrPDB 193 2e-49 3UIM-A nrPDB 192 2e-49 5IKW-A nrPDB 192 2e-49 2Y4I-B nrPDB 192 4e-49 4EUT-A nrPDB 192 5e-49 5TE0-A nrPDB 192 5e-49 2RIO-A nrPDB 190 1e-48 3MDY-A nrPDB 189 2e-48 6HMD-A nrPDB 189 2e-48 1PY5-A nrPDB 189 3e-48 6O8B-A nrPDB 189 3e-48 2H34-A nrPDB 189 3e-48 4MD7-E nrPDB 189 3e-48 6NT9-A nrPDB 189 3e-48 5L2Q-C nrPDB 188 7e-48 5VC6-A nrPDB 187 9e-48 6EII-A nrPDB 187 1e-47 2WO6-A nrPDB 187 1e-47 5XVU-A nrPDB 186 2e-47 4CRL-A nrPDB 186 3e-47 5AR8-A nrPDB 185 3e-47 2PVN-A nrPDB 185 3e-47 3REP-A nrPDB 184 8e-47 4PL5-B nrPDB 184 9e-47 2JD5-A nrPDB 184 1e-46 6HV0-A nrPDB 183 2e-46 5E8V-A nrPDB 181 7e-46 4IAN-A nrPDB 181 9e-46 3SOC-A nrPDB 180 1e-45 2QKW-B nrPDB 180 2e-45 5UNP-A nrPDB 180 2e-45 5VDK-A nrPDB 179 3e-45 3RAW-A nrPDB 177 1e-44 5XD6-A nrPDB 177 1e-44 4MWI-A nrPDB 176 2e-44 2QLU-A nrPDB 174 7e-44 4LFI-A nrPDB 174 8e-44 4M66-A nrPDB 174 9e-44 4BTF-A nrPDB 174 1e-43 4M69-B nrPDB 173 2e-43 3VHK-A nrPDB 169 2e-42 5USZ-A nrPDB 169 3e-42 3G2F-A nrPDB 169 3e-42 3LLT-A nrPDB 168 7e-42 3HNG-A nrPDB 167 2e-41 6BFN-A nrPDB 166 2e-41 3QD2-B nrPDB 165 6e-41 4F9B-A nrPDB 164 9e-41 4L00-A nrPDB 158 7e-39 4EAL-A nrPDB 155 4e-38 4RT7-A nrPDB 154 1e-37 3SV0-A nrPDB 152 3e-37 5FQD-C nrPDB 151 7e-37 5X18-A nrPDB 150 1e-36 2CMW-A nrPDB 150 1e-36 4TN6-A nrPDB 150 2e-36 5X1R-A nrPDB 149 4e-36 2CHL-A nrPDB 149 4e-36 2C47-A nrPDB 148 4e-36 2PZI-A nrPDB 146 2e-35 4Y12-A nrPDB 146 2e-35 5M07-A nrPDB 145 7e-35 4BTK-A nrPDB 143 2e-34 4NFN-A nrPDB 142 3e-34 4NT4-A nrPDB 142 5e-34 4I94-A nrPDB 140 1e-33 4L68-A nrPDB 138 8e-33 4XHH-A nrPDB 132 3e-31 4XHL-A nrPDB 131 1e-30 5UV4-A nrPDB 129 4e-30 5OAT-A nrPDB 128 4e-30 6EAS-A nrPDB 125 7e-29 4JRN-A nrPDB 116 2e-26 6J6I-B nrPDB 116 2e-26 5CLR-A nrPDB 93 4e-19 Sequences not found previously or not previously below threshold: 2X7G-A nrPDB 154 9e-38 4WUA-A nrPDB 154 1e-37 5J0A-A nrPDB 144 8e-35 5C01-A nrPDB 137 2e-32 4WOV-A nrPDB 137 2e-32 1CSN-A nrPDB 133 2e-31 6EQI-C nrPDB 116 3e-26 5UU1-A nrPDB 95 1e-19 4O1O-A nrPDB 94 2e-19 2LAV-A nrPDB 87 2e-17 2RSV-A nrPDB 87 2e-17 4IX6-A nrPDB 80 3e-15 5DMZ-A nrPDB 78 7e-15 4OAU-C nrPDB 78 8e-15 6G4J-A nrPDB 73 2e-13 6EWX-A nrPDB 72 5e-13 5GZ9-A nrPDB 70 2e-12 4CI6-B nrPDB 70 3e-12 5GZA-A nrPDB 69 4e-12 6BHC-A nrPDB 68 1e-11 2EHB-D nrPDB 64 1e-10 5VE6-A nrPDB 64 2e-10 6M7Z-A nrPDB 62 5e-10 2JII-A nrPDB 61 2e-09 4AZW-A nrPDB 60 2e-09 4AZV-A nrPDB 60 3e-09 4CYJ-A nrPDB 55 6e-08 3BYV-A nrPDB 54 2e-07 4CZY-B nrPDB 53 5e-07 3DZO-A nrPDB 52 6e-07 2W1Z-A nrPDB 52 6e-07 3ENH-A nrPDB 51 9e-07 4BWP-A nrPDB 51 2e-06 4WWA-A nrPDB 46 4e-05 6G38-A nrPDB 45 6e-05 3Q60-A nrPDB 42 7e-04 1TQM-A nrPDB 42 7e-04 5YK0-A nrPDB 41 0.001 4BVU-A nrPDB 40 0.004 4OTP-A nrPDB 38 0.011 6G5I-z nrPDB 38 0.015 6FAI-l nrPDB 34 0.15 4ESA-B nrPDB 33 0.30 6G18-v nrPDB 33 0.31 >4CFF-A nrPDB Length = 571 Score = 871 bits (2250), Expect = 0.0, Method: Composition-based stats. Identities = 552/552 (100%), Positives = 552/552 (100%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK Sbjct: 20 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 79 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF Sbjct: 80 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 139 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA Sbjct: 140 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS Sbjct: 200 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 259 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF Sbjct: 260 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 319 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 360 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP Sbjct: 320 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 379 Query: 361 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 420 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY Sbjct: 380 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 439 Query: 421 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 480 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR Sbjct: 440 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 499 Query: 481 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 540 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF Sbjct: 500 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF 559 Query: 541 EMCASLITTLAR 552 EMCASLITTLAR Sbjct: 560 EMCASLITTLAR 571 >5EZV-A nrPDB Length = 560 Score = 862 bits (2228), Expect = 0.0, Method: Composition-based stats. Identities = 523/551 (94%), Positives = 531/551 (96%), Gaps = 6/551 (1%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI Sbjct: 16 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 75 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ Sbjct: 76 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 135 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA Sbjct: 136 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 195 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV Sbjct: 196 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 255 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE Sbjct: 256 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 315 Query: 302 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPP 361 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPP SF+DD + Sbjct: 316 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPD-SFLDDHHL---- 370 Query: 362 GLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYR 421 +PHPER+P L+A++P+AR LD LN K K VKKAKWHLGIRSQSKPYDIMAEVYR Sbjct: 371 -TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVKKAKWHLGIRSQSKPYDIMAEVYR 429 Query: 422 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS 481 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS Sbjct: 430 AMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRS 489 Query: 482 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFE 541 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFE Sbjct: 490 GSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFE 549 Query: 542 MCASLITTLAR 552 MCASLITTLAR Sbjct: 550 MCASLITTLAR 560 >4REW-A nrPDB Length = 540 Score = 832 bits (2150), Expect = 0.0, Method: Composition-based stats. Identities = 409/546 (74%), Positives = 466/546 (85%), Gaps = 8/546 (1%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G VKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGKI+REIQNL Sbjct: 1 GSVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNL 60 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 KLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLFQQILS VD Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 180 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248 LYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI G+FY P+YLN SV +LL HM Sbjct: 181 LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 240 Query: 249 LQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVM 308 LQVDP+KRA+IKDIREHEWFKQDLP YLFPEDPSY + +IDDEA+KEVCEKFEC+E EV+ Sbjct: 241 LQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL 300 Query: 309 NSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPE 368 + LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP SF+DD + +PHPE Sbjct: 301 SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL-----TRPHPE 354 Query: 369 RMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDF 428 R+P L+A++P+AR LD LN K K V+KAKWHLGIRSQS+P DIMAEV RA+KQLD+ Sbjct: 355 RVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDY 414 Query: 429 EWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQR 488 EWKVVN Y+LRVRRKNPVT Y KMSLQLY VD+R+YLLDF+SIDD + SG++TPQR Sbjct: 415 EWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDGITAAASGTATPQR 474 Query: 489 SCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTG--STLSSVSPRLGSHTMDFFEMCASL 546 S S + + S A+ S SLT S+T S+ ++PR GSHT++FFEMCA+L Sbjct: 475 SGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANL 534 Query: 547 ITTLAR 552 I LA+ Sbjct: 535 IKILAQ 540 >4CFH-A nrPDB Length = 493 Score = 727 bits (1876), Expect = 0.0, Method: Composition-based stats. Identities = 387/478 (80%), Positives = 432/478 (90%), Gaps = 6/478 (1%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 MAEKQKHDGRVKIGHY+LGDTLGVGTFGKVK+G+H+LTGHKVAVKILNRQKIRSLDVVGK Sbjct: 20 MAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK 79 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I+REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLF Sbjct: 80 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 139 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA Sbjct: 140 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI G+FY P+YLN S Sbjct: 200 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 259 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 V +LL HMLQVDP+KRATIKDIREHEWFKQDLP YLFPEDPSY + +IDDEA+KEVCEKF Sbjct: 260 VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKF 319 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 360 EC+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP SF+DD + Sbjct: 320 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDHHL--- 375 Query: 361 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 420 +PHPER+P L+A++P+AR LD LN K K V+KAKWHLGIRSQS+P DIMAEV Sbjct: 376 --TRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVC 433 Query: 421 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVE 478 RA+KQLD+EWKVVN Y+LRVRRKNPVT + KMSLQLY VD+R+YLLDF+SIDDE++E Sbjct: 434 RAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEILE 491 >4RED-A nrPDB Length = 351 Score = 500 bits (1288), Expect = e-142, Method: Composition-based stats. Identities = 293/348 (84%), Positives = 319/348 (91%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 M H G VKIGHY+LGDTLGVGTFGKVK+G+H+LTGH VAVKILNRQKIRSLDVVGK Sbjct: 1 MGHHHHHHGSVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGK 60 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I+REIQNLKLFRHPHIIKLYQVISTP+D FMVMEYVSGGELFDYICK+GR++E E+RRLF Sbjct: 61 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF 120 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQILS VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA Sbjct: 121 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVISGRLYAGPEVDIWS GVILYALLCGTLPFDD+HVPTLFKKI G+FY P+YLN S Sbjct: 181 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS 240 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 V +LL HMLQVDP+KRA+IKDIREHEWFKQDLP YLFPEDPSY +IDDEA+KEVCEKF Sbjct: 241 VISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKF 300 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPS 348 EC+E EV++ LY+ + QD LAVAYHLIIDNRRIMN+A +FYLA+SPP Sbjct: 301 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD 348 >2YZA-A nrPDB Length = 276 Score = 430 bits (1106), Expect = e-121, Method: Composition-based stats. Identities = 273/274 (99%), Positives = 273/274 (99%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI Sbjct: 3 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 62 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS Sbjct: 63 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 122 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR SCGSPNYAAPEVI Sbjct: 123 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVI 182 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL Sbjct: 183 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 242 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 279 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE Sbjct: 243 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 276 >6C9D-A nrPDB Length = 459 Score = 408 bits (1049), Expect = e-114, Method: Composition-based stats. Identities = 158/437 (36%), Positives = 240/437 (54%), Gaps = 58/437 (13%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 ++Q H IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ + K+ Sbjct: 14 TDEQPH-----IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS-LQKL 67 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE++ +K+ HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+ Sbjct: 68 FREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 127 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QI+SAV YCH+ +VHRDLK EN+LLD MN KIADFG SN + G L CGSP YAA Sbjct: 128 QIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAA 187 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE+ G+ Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ Sbjct: 188 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 247 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296 LL +L ++P+KR +++ I + W +++L Y P+ D ID Sbjct: 248 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDI------ 301 Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSA 356 + G +D++ N ++NQ + +A+ Sbjct: 302 -------------MVTMGFARDEI---------NDALINQKYDEVMAT------------ 327 Query: 357 MHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIM 416 +I G KP ++ PK R + ++ KP+SL + W + S P D+M Sbjct: 328 -YILLGRKPPEFEGGESLSGEPKERDKEEGKDS-KPRSL---RFTWSMKTTSSMDPNDMM 382 Query: 417 AEVYRAM--KQLDFEWK 431 E+ + + D+E K Sbjct: 383 REIRKVLDANNCDYEQK 399 >3H4J-B nrPDB Length = 336 Score = 400 bits (1028), Expect = e-112, Method: Composition-based stats. Identities = 172/336 (51%), Positives = 239/336 (71%), Gaps = 8/336 (2%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 MA ++H IG Y++ +TLG G+FGKVK+ H T KVA+K ++RQ ++ D+ + Sbjct: 1 MAISKRH-----IGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMR 55 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 ++REI LKL RHPHIIKLY VI+TPTD MV+EY GGELFDYI + R+ E E RR F Sbjct: 56 VEREISYLKLLRHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFF 114 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 QQI+ A++YCHRH +VHRDLKPEN+LLD ++N KIADFGLSN+M+DG FL+TSCGSPNYA Sbjct: 115 QQIICAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYA 174 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 APEVI+G+LYAGPEVD+WSCG++LY +L G LPFDDE +P LFKK+ V+ +P++L+ Sbjct: 175 APEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPG 234 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 +L+ M+ DP++R TI++IR WF +LP YL P + + D V ++ E Sbjct: 235 AQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEE-VQGSYADSRIVSKLGEAM 293 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQ 336 +E ++ +L S D +++ AY+L+ +N+ I + Sbjct: 294 GFSEDYIVEALRS-DENNEVKEAYNLLHENQVIQEK 328 >4D28-A nrPDB Length = 446 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 147/423 (34%), Positives = 230/423 (54%), Gaps = 35/423 (8%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 ++G Y +G T+G GTF KVK + TG VA+KI+ + I +V +IKREI +K+ Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 RHP+I++LY+V+++ + ++V+E+V+GGELFD I GR++E E+R+ FQQ++ AV +CH Sbjct: 67 RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCH 126 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRLY 190 V HRDLKPEN+LLD + N K++DFGLS + +G E L +CG+PNY APEV+SG+ Y Sbjct: 127 SKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGY 186 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 G DIWSCGVIL+ +L G LPF + +P L++KI F P + + V L+ +L Sbjct: 187 DGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLIHRILD 246 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 +P R I+ I++ WF+++ E+ + N+ D AV + E S V + Sbjct: 247 PNPKTRIQIQGIKKDPWFRKNYVPIRAREEE--EVNLDDIRAVFDGIEG-----SYVAEN 299 Query: 311 LYSGDPQDQLAVAYHLI-----------IDNRRIMNQASEFYLASSPPSGSFMDDSAMHI 359 + D + A+ +I D R+ + +++ PS + A+ Sbjct: 300 VERNDEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVAN 359 Query: 360 PPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEV 419 G K H + L+ L++ K LAV + + P M +V Sbjct: 360 SMGFKSHTRNF----------KTRLEGLSSIKAGQLAVVIEIYEVA------PSLFMVDV 403 Query: 420 YRA 422 +A Sbjct: 404 RKA 406 >3MN3-A nrPDB Length = 271 Score = 371 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 165/268 (61%), Positives = 207/268 (77%), Gaps = 1/268 (0%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 IG+Y + TLG G+FGKVK+ H TG KVA+KI+N++ + D+ G+I+REI L+L R Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 62 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HPHIIKLY VI + + MV+EY G ELFDYI + ++ E EARR FQQI+SAV+YCHR Sbjct: 63 HPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 H +VHRDLKPEN+LLD H+N KIADFGLSN+M+DG FL+TSCGSPNYAAPEVISG+LYAG Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 PEVD+WSCGVILY +LC LPFDDE +P LFK I GV+ +P++L+ A L+ ML V+ Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVN 241 Query: 253 PLKRATIKDIREHEWFKQDLPSYLFPED 280 PL R +I +I + +WFK DLP YL P D Sbjct: 242 PLNRISIHEIMQDDWFKVDLPEYLLPPD 269 >4CZT-A nrPDB Length = 464 Score = 367 bits (942), Expect = e-102, Method: Composition-based stats. Identities = 137/389 (35%), Positives = 221/389 (56%), Gaps = 20/389 (5%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 H GR ++G Y LG TLG GTF KVK + G VA+K+++++K+ ++ +IKREI Sbjct: 4 HSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIS 63 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 +KL +HP++I++++V+++ T + V+E+V+GGELFD I +GR++E EAR+ FQQ+++A Sbjct: 64 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINA 123 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPE 183 VDYCH V HRDLKPEN+LLDA+ K++DFGLS + + L T+CG+PNY APE Sbjct: 124 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 183 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 VI+ + Y G + D+WSCGVIL+ L+ G LPF+D ++ +L+KKI F P + + S Sbjct: 184 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 243 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECT 303 L+ +L +P R T ++ E+EWFK+ Y P+ + D ++ D +A+ + + + Sbjct: 244 LIKRILDPNPATRITFAEVIENEWFKK---GYKAPKFENADVSLDDVDAIFDDSGE---S 297 Query: 304 ESEVMNSLYSGDPQDQLAVAYHLI-----------IDNRRIMNQASEFYLASSPPSGSFM 352 ++ V+ G A+ LI + + + + + + S + Sbjct: 298 KNLVVERREEGLKTPVTMNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVT 357 Query: 353 DDSAMHIPPGLKPHPERMPPLIADSPKAR 381 A P G + R Sbjct: 358 KIEAAAAPMGFDVKTNNYKMKLTGEKSGR 386 >5ES1-A nrPDB Length = 328 Score = 367 bits (942), Expect = e-102, Method: Composition-based stats. Identities = 140/330 (42%), Positives = 203/330 (61%), Gaps = 18/330 (5%) Query: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62 E+Q H +G+Y L T+G G F KVK+ H LTG +VA+KI+++ ++ + + K+ Sbjct: 9 EEQPH-----VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLF 62 Query: 63 REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122 RE++ +K HP+I+KL++VI T ++VMEY S GE+FDY+ HGR++E EAR F+Q Sbjct: 63 REVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQ 122 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 I+SAV YCH+ +VHRDLK EN+LLDA N KIADFG SN + G L T CGSP YAAP Sbjct: 123 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAP 182 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 242 E+ G+ Y GPEVDIWS GVILY L+ G+LPFD ++ L +++ G + +P Y++ Sbjct: 183 ELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCE 242 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEVC 297 ++L L ++P KR T++ I + +W ++L Y PE+ D I EV Sbjct: 243 SILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRI------EVM 296 Query: 298 EKFECTESEVMNSLYSGDPQDQLAVAYHLI 327 T E+ SL S +++ Y L+ Sbjct: 297 VGMGYTREEIKESLTSQK-YNEVTATYLLL 325 >5KZ7-A nrPDB Length = 346 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 143/331 (43%), Positives = 204/331 (61%), Gaps = 18/331 (5%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 A++Q H IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ S + K+ Sbjct: 26 ADEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS-LQKL 79 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE++ +K+ HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+ Sbjct: 80 FREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 139 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QI+SAV YCH+ +VHRDLK EN+LLDA MN KIADFG SN + G L T CGSP YAA Sbjct: 140 QIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAA 199 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE+ G+ Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ Sbjct: 200 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 259 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDPSYDANVIDDEAVKEV 296 LL L ++P KR T++ I + W +L Y+ P D E+ Sbjct: 260 ENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRR------TEL 313 Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327 T E+ +SL G +++ Y L+ Sbjct: 314 MVSMGYTREEIQDSL-VGQRYNEVMATYLLL 343 >2QNJ-A nrPDB Length = 328 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 140/331 (42%), Positives = 207/331 (62%), Gaps = 18/331 (5%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 +++Q H IG+Y L T+G G F KVK+ H LTG +VA+KI+++ ++ + K+ Sbjct: 5 SDEQPH-----IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS-LQKL 58 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE++ +K+ HP+I+KL++VI T +++MEY SGGE+FDY+ HGR++E EAR F+ Sbjct: 59 FREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFR 118 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QI+SAV YCH+ +VHRDLK EN+LLDA MN KIADFG SN + G L T CGSP YAA Sbjct: 119 QIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAA 178 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE+ G+ Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ Sbjct: 179 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 238 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296 LL L ++P+KR T++ I + W + +L ++ PE D ID + Sbjct: 239 ENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRID------I 292 Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327 ++ E+ SL S D++ Y L+ Sbjct: 293 MVGMGYSQEEIQESL-SKMKYDEITATYLLL 322 >5JN2-A nrPDB Length = 525 Score = 360 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 185/365 (50%), Gaps = 15/365 (4%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 +H + Y LG G+FG+V + + ++TG + AVK++++++++ + RE+ Sbjct: 59 QHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREV 118 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 Q LK HP+I+KLY+ F++V E +GGELFD I R E++A R+ +Q+LS Sbjct: 119 QLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLS 178 Query: 126 AVDYCHRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 + Y H++ +VHRDLKPEN+LL N +I DFGLS + ++ G+ Y AP Sbjct: 179 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 238 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LN 238 EV+ G + D+WS GVILY LL G PF+ + + KK+ G + P++ ++ Sbjct: 239 EVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 296 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 S L+ ML P R + +D +HEW + + + PS D +++ + + Sbjct: 297 ESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQK 356 Query: 299 KFECTESEVMNSLYSGDPQDQLAVAYHLIIDN------RRIMNQASEFYLASSPPSGSFM 352 + + + L S D +L +H + N R + + + + S + Sbjct: 357 LAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASML 416 Query: 353 DDSAM 357 D SA+ Sbjct: 417 DASAV 421 >2HAK-A nrPDB Length = 328 Score = 343 bits (880), Expect = 1e-94, Method: Composition-based stats. Identities = 138/331 (41%), Positives = 204/331 (61%), Gaps = 18/331 (5%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 ++Q H IG+Y L T+G G F KVK+ H LTG +VAVKI+++ ++ + K+ Sbjct: 8 TDEQPH-----IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS-LQKL 61 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE++ +K+ HP+I+KL++VI T ++VMEY SGGE+FDY+ HGR++E EAR F+ Sbjct: 62 FREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFR 121 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 QI+SAV YCH+ +VHRDLK EN+LLD MN KIADFG SN + G L T CGSP YAA Sbjct: 122 QIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAA 181 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE+ G+ Y GPEVD+WS GVILY L+ G+LPFD +++ L +++ G + IP Y++ Sbjct: 182 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 241 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWF-----KQDLPSYLFPEDPSYDANVIDDEAVKEV 296 LL +L ++P+KR +++ I + W +++L Y P+ D ID + Sbjct: 242 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRID------I 295 Query: 297 CEKFECTESEVMNSLYSGDPQDQLAVAYHLI 327 E+ ++L D++ Y L+ Sbjct: 296 MVTMGFARDEINDAL-INQKYDEVMATYILL 325 >3NCG-A nrPDB Length = 486 Score = 334 bits (858), Expect = 4e-92, Method: Composition-based stats. Identities = 103/341 (30%), Positives = 170/341 (49%), Gaps = 11/341 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y + LG G+FG+V + ++T + AVK++N+ ++ D I RE++ LK H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDT-STILREVELLKKLDH 80 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+KL++++ + F++V E +GGELFD I K R E +A R+ +Q+ S + Y H+H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 134 MVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHRDLKPEN+LL++ + KI DFGLS ++ G+ Y APEV+ G Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-- 198 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLM 246 + D+WS GVILY LL GT PF ++ + K++ G + P++ ++ L+ Sbjct: 199 YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIR 258 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSY-LFPEDPSYDANVIDDEAVKEVCEKFECTES 305 ML P R T EH W ++ + PS ++ + + + + + Sbjct: 259 KMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAALL 318 Query: 306 EVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP 346 + + L + D QL + + N M E Sbjct: 319 YMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRGYHE 359 >5YKS-A nrPDB Length = 377 Score = 334 bits (856), Expect = 8e-92, Method: Composition-based stats. Identities = 124/354 (35%), Positives = 199/354 (56%), Gaps = 12/354 (3%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 K+ +DG++ G Y L TLG G F VK+ H TG KVAVK++++ K+ +L G + + Sbjct: 26 KRGYDGKI-AGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQ 83 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQ 122 E++ +KL +HP+I++LY+VI T T ++++E GG++FDYI KH + E A++ F Q Sbjct: 84 EVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQ 143 Query: 123 ILSAVDYCHRHMVVHRDLKPENV-LLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 I+ A+ YCH+ VVHRDLKPENV + K+ DFG SN G+ L TSCGS Y+A Sbjct: 144 IVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSA 203 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PE++ G Y P VDIWS GVIL+ L+CG PF + + I + +P ++++ Sbjct: 204 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKEC 263 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED-PSYDANVIDDEAVKEVCEKF 300 L+ MLQ DP +RA++++I H W + PS + P + +E + ++ Sbjct: 264 KDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRM 323 Query: 301 EC----TESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGS 350 ++ +L + + + + Y L+ + RI+ + E + + S S Sbjct: 324 VLGDIADRDAIVEALET-NRYNHITATYFLLAE--RILREKQEKEIQTRSASPS 374 >4YZB-A nrPDB Length = 491 Score = 329 bits (844), Expect = 2e-90, Method: Composition-based stats. Identities = 103/357 (28%), Positives = 181/357 (50%), Gaps = 15/357 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y LG G+FG+V + + ++TG + AVK++++++++ + +E++ LK H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+KLY+ F++V E +GGELFD I R E++A R+ +Q+LS + Y H++ Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKN 149 Query: 134 MVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHRDLKPEN+LL+ N +I DFGLS + ++ G+ Y APEV+ G Sbjct: 150 KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT-- 207 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLM 246 + D+WS GVILY LL G PF+ + + KK+ G F P++ ++ L+ Sbjct: 208 YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIR 267 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESE 306 ML P R + +D EHEW K + + PS ++ +++ + + Sbjct: 268 KMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLY 327 Query: 307 VMNSLYSGDPQDQLAVAYHLIIDN------RRIMNQASEFYLASSPPSGSFMDDSAM 357 + + L + + +L + + N ++ + + + S +D SA+ Sbjct: 328 MGSKLTTNEETVELNKIFQRMDKNGDGQLDKQELMEGYVELMKLKGEDVSALDQSAI 384 >4MVF-A nrPDB Length = 506 Score = 329 bits (843), Expect = 2e-90, Method: Composition-based stats. Identities = 99/283 (34%), Positives = 153/283 (54%), Gaps = 13/283 (4%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 H G+++ Y++ + LG GT+G V G ++T A+K + ++++++ + +EI+ Sbjct: 51 HSGKLE-DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN---RFFQEIE 106 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 +K HP+I+KLY+ +++ME SG ELFD I ++G E A + +QI SA Sbjct: 107 IMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSA 166 Query: 127 VDYCHRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 + Y H +VHRDLKPEN L + KI DFGLS + GEF T G+P Y AP+ Sbjct: 167 IFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQ 226 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY----LNR 239 V+ G+ + DIWS GVI+Y LLCG PF + + KK++ G F E ++ Sbjct: 227 VLDGK--YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISS 284 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPS 282 L+ +L +P +R TI++ H W Q S+ E S Sbjct: 285 DAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSS 327 >3LIJ-A nrPDB Length = 494 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 104/353 (29%), Positives = 169/353 (47%), Gaps = 15/353 (4%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + K+ H + Y LG G +G+V + ++T + A+KI+ + + S K Sbjct: 28 ITSKKGHLSEM----YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSV-STSSNSK 82 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + E+ LKL HP+I+KLY ++++VME GGELFD I + E++A + Sbjct: 83 LLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVII 142 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSP 177 +Q+LS V Y H+H +VHRDLKPEN+LL++ KI DFGLS + + + ++ G+ Sbjct: 143 KQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTA 202 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PE 235 Y APEV+ R + D+WS GVIL+ LL G PF + + +K+ G + PE Sbjct: 203 YYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPE 260 Query: 236 Y--LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF-PEDPSYDANVIDDEA 292 + ++ L+ MLQ D +R + + EH W K+ E PS + + Sbjct: 261 WKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLANAIENMRK 320 Query: 293 VKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASS 345 + + + + + L S + +L + I N E S Sbjct: 321 FQNSQKLAQAALLYMASKLTSQEETKELTDIFRHIDKNGDGQLDRQELIDGYS 373 >4CQG-A nrPDB Length = 331 Score = 324 bits (832), Expect = 4e-89, Method: Composition-based stats. Identities = 128/303 (42%), Positives = 179/303 (59%), Gaps = 5/303 (1%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + +Y L +T+G G F KVK+ H LTG VA+KI+++ + S + ++K EI LK R Sbjct: 8 LKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS--DLPRVKTEIDALKSLR 65 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H HI +LY V+ T FMV+EY GGELFDYI R+ E E R +F+QILSAV Y H Sbjct: 66 HQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHS 125 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLY 190 HRDLKPEN+L D + K+ DFGL + L+ CGS YAAPE+I G+ Y Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSY 185 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 G E D+WS G++LY L+CG LPFDD++V L+KKI G + +P++L+ S LL MLQ Sbjct: 186 LGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQ 245 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 VDP KR +++++ H W QD S +D++ V E+ + + + Sbjct: 246 VDPKKRISMRNLLNHPWVMQDY-SCPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDL 304 Query: 311 LYS 313 + S Sbjct: 305 ISS 307 >3HZT-A nrPDB Length = 467 Score = 324 bits (832), Expect = 5e-89, Method: Composition-based stats. Identities = 97/340 (28%), Positives = 164/340 (48%), Gaps = 10/340 (2%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y LG G +G+V + + +LTG + A+KI+ + + + G + E+ LK H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+KLY+ ++++VME GGELFD I + E++A + +Q+LS Y H+H Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHRDLKPEN+LL++ KI DFGLS G ++ G+ Y APEV+ R Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RKK 181 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLM 246 + D+WSCGVILY LLCG PF + + K++ G F P++ ++ L+ Sbjct: 182 YDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVK 241 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPS-YLFPEDPSYDANVIDDEAVKEVCEKFECTES 305 ML +P KR + ++ H W + + + + + + + + + Sbjct: 242 LMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKKFQSSQKLAQAAML 301 Query: 306 EVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASS 345 + + L + + +L + + +N E Sbjct: 302 FMGSKLTTLEETKELTQIFRQLDNNGDGQLDRKELIEGYR 341 >4D2V-A nrPDB Length = 356 Score = 324 bits (830), Expect = 7e-89, Method: Composition-based stats. Identities = 132/310 (42%), Positives = 183/310 (59%), Gaps = 11/310 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + +Y L +T+G G F KVK+ H LTG VA+KI+++ + S + +IK EI+ LK R Sbjct: 28 LKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLR 85 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H HI +LY V+ T FMV+EY GGELFDYI R+ E E R +F+QI+SAV Y H Sbjct: 86 HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 145 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE--FLRTSCGSPNYAAPEVISGRLY 190 HRDLKPEN+L D + K+ DFGL + L+ CG+ YAAPE+I G+ Y Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSY 205 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 G E D+WS G++LY L+CG LPFDD+ L KI G + +P++L+ S LL MLQ Sbjct: 206 LGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQ 265 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFP-EDPSYDANV-IDDEAVKEVCEKFECTESEVM 308 VDP KR ++K++ H W QD Y +P E S + + +DD+ V E+ + Sbjct: 266 VDPKKRISMKNLLNHPWIMQD---YNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTME 322 Query: 309 N--SLYSGDP 316 + SL+ D Sbjct: 323 DLISLWQYDH 332 >5KCV-A nrPDB Length = 460 Score = 322 bits (826), Expect = 2e-88, Method: Composition-based stats. Identities = 106/306 (34%), Positives = 157/306 (51%), Gaps = 12/306 (3%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 K KH RV + + LG GTFGKV + + + TG A+KIL ++ I + D V Sbjct: 154 KPKH--RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT 211 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 E + L+ RHP + L T VMEY +GGELF ++ + E AR +I Sbjct: 212 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 271 Query: 124 LSAVDYCHR-HMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAA 181 +SA+DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y A Sbjct: 272 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 331 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSV 241 PEV+ Y G VD W GV++Y ++CG LPF ++ LF+ I P L Sbjct: 332 PEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEA 390 Query: 242 ATLLMHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVK 294 +LL +L+ DP +R K+I +H +F + +++ + P + V + + Sbjct: 391 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 450 Query: 295 EVCEKF 300 E+F Sbjct: 451 YFDEEF 456 >4YNZ-A nrPDB Length = 342 Score = 321 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 136/325 (41%), Positives = 202/325 (62%), Gaps = 10/325 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 +G Y L TLG G G VK+G H +T KVA+KI+NR+K+ S V+ K++REI LKL Sbjct: 9 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIE 67 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HPH++KL+ V ++V+E+VSGGELFDY+ K GR+ EAR+ F+QI+SA+D+CH Sbjct: 68 HPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 127 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 H + HRDLKPEN+LLD N +IADFG++++ L TSCGSP+YA PEVI G Y G Sbjct: 128 HSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 + D+WSCGVIL+ALL G LPFDD+++ L +K++ GVF++P ++ +LL M++VD Sbjct: 188 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVD 247 Query: 253 PLKRATIKDIREHEWF--KQDLPSYLFPEDPSYDANVID-----DEAVKEVCEKFECTES 305 +R T++ I++H W+ ++ P P + D V + C Sbjct: 248 AARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRD 307 Query: 306 --EVMNSLYSGDPQDQLAVAYHLII 328 +++ L S + + + + L+ Sbjct: 308 RNKLLQDLLSEEENQEKMIYFLLLD 332 >3MA6-A nrPDB Length = 298 Score = 321 bits (824), Expect = 4e-88, Method: Composition-based stats. Identities = 95/271 (35%), Positives = 152/271 (56%), Gaps = 9/271 (3%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 +H + Y LG G+FG+V + + ++TG + AVK++++++++ + RE+ Sbjct: 24 QHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREV 83 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 Q LK HP+I+KLY+ F++V E +GGELFD I R E++A R+ +Q+LS Sbjct: 84 QLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLS 143 Query: 126 AVDYCHRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 + Y H++ +VHRDLKPEN+LL N +I DFGLS + ++ G+ Y AP Sbjct: 144 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAP 203 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LN 238 EV+ G + D+WS GVILY LL G PF+ + + KK+ G + P++ ++ Sbjct: 204 EVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS 261 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 S L+ ML P R + +D +HEW + Sbjct: 262 ESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292 >3MV5-A nrPDB Length = 342 Score = 321 bits (822), Expect = 6e-88, Method: Composition-based stats. Identities = 104/302 (34%), Positives = 155/302 (51%), Gaps = 10/302 (3%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D RV + + LG GTFGKV + + + TG A+KIL ++ I + D V E + Sbjct: 4 DPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 63 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 L+ RHP + L T VMEY +GGELF ++ + E AR +I+SA+ Sbjct: 64 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 128 DYCHR-HMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVI 185 DY H VV+RDLK EN++LD + KI DFGL + DG ++T CG+P Y APEV+ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 Y G VD W GV++Y ++CG LPF ++ LF+ I P L +LL Sbjct: 184 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLL 242 Query: 246 MHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVKEVCE 298 +L+ DP +R K+I +H +F + +++ + P + V + + E Sbjct: 243 SGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 302 Query: 299 KF 300 +F Sbjct: 303 EF 304 >4RGJ-A nrPDB Length = 520 Score = 319 bits (819), Expect = 1e-87, Method: Composition-based stats. Identities = 103/345 (29%), Positives = 171/345 (49%), Gaps = 11/345 (3%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V Y LG G+FG+V + + TGH+ A+K+++++ ++ + RE++ LK+ Sbjct: 57 VFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKM 116 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 H +I+KLY+ +++V + +GGELFD I R E++A R+ +QILS + Y Sbjct: 117 LDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYM 176 Query: 131 HRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H++ VVHRDLKPEN+LL M KI DFGLS + ++ G+ Y AP+V+ Sbjct: 177 HKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLH 236 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVA 242 G + DIWSCGVILY LL G PF+ + + KK+ G + P++ ++ Sbjct: 237 GT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAK 294 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK-QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301 L+ ML R + +D EHEW K L + PS + ++ + + + + Sbjct: 295 DLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQ 354 Query: 302 CTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP 346 + + L + D +L + + N +E + Sbjct: 355 AALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKE 399 >3DXN-A nrPDB Length = 287 Score = 318 bits (814), Expect = 5e-87, Method: Composition-based stats. Identities = 93/262 (35%), Positives = 143/262 (54%), Gaps = 9/262 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y LG G +G+V + + +LTG + A+KI+ + + + G + E+ LK H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+KLY+ ++++VME GGELFD I + E++A + +Q+LS Y H+H Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHRDLKPEN+LL++ KI DFGLS G ++ G+ Y APEV+ R Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RKK 198 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLM 246 + D+WSCGVILY LLCG PF + + K++ G F P++ ++ L+ Sbjct: 199 YDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVK 258 Query: 247 HMLQVDPLKRATIKDIREHEWF 268 ML +P KR + ++ H W Sbjct: 259 LMLTYEPSKRISAEEALNHPWI 280 >5WAX-A nrPDB Length = 310 Score = 317 bits (813), Expect = 6e-87, Method: Composition-based stats. Identities = 116/307 (37%), Positives = 162/307 (52%), Gaps = 16/307 (5%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 HDG Y L +G G FG ++ ++ G VAVK + R + + ++REI Sbjct: 8 HDG----DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGE----KIDENVQREII 59 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 N + RHP+II+ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S Sbjct: 60 NHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISG 119 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 V YCH V HRDLK EN LLD KI DFG S +++ G+P Y APEV Sbjct: 120 VSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 179 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEY--LN 238 + + Y G D+WSCGV LY +L G PF+D P F+K I G + IP+Y ++ Sbjct: 180 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHIS 239 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 L+ + +P R TI +IR H WF ++LP+ L + ++ ++ + E Sbjct: 240 PECQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQPMQSMDE 299 Query: 299 KFECTES 305 + Sbjct: 300 IMQILAE 306 >2JDO-A nrPDB Length = 342 Score = 317 bits (812), Expect = 9e-87, Method: Composition-based stats. Identities = 101/301 (33%), Positives = 153/301 (50%), Gaps = 9/301 (2%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D +V + + LG GTFGKV + + TG A+KIL ++ I + D V E + Sbjct: 4 DPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 63 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 L+ RHP + L T VMEY +GGELF ++ + E AR +I+SA+ Sbjct: 64 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVIS 186 +Y H VV+RD+K EN++LD + KI DFGL +SDG ++T CG+P Y APEV+ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G VD W GV++Y ++CG LPF ++ LF+ I P L+ +LL Sbjct: 184 DNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLA 242 Query: 247 HMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPED--PSYDANVIDDEAVKEVCEK 299 +L+ DP +R K++ EH +F + + P + V + + ++ Sbjct: 243 GLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE 302 Query: 300 F 300 F Sbjct: 303 F 303 >3Q5I-A nrPDB Length = 504 Score = 317 bits (812), Expect = 1e-86, Method: Composition-based stats. Identities = 97/352 (27%), Positives = 168/352 (47%), Gaps = 20/352 (5%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRS---------- 54 +K +G++ ++ + LG G +G+V + + + + A+K++ + + Sbjct: 28 RKKEGKIGESYFKV-RKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNI 86 Query: 55 LDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM 114 +I EI LK HP+IIKL+ V F++V E+ GGELF+ I + +E Sbjct: 87 EKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDEC 146 Query: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHM---NAKIADFGLSNMMSDGEFLR 171 +A + +QILS + Y H+H +VHRD+KPEN+LL+ N KI DFGLS+ S LR Sbjct: 147 DAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLR 206 Query: 172 TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF 231 G+ Y APEV+ + + D+WSCGVI+Y LLCG PF ++ + KK+ G + Sbjct: 207 DRLGTAYYIAPEVLKKK--YNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKY 264 Query: 232 YIP----EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANV 287 Y + ++ L+ ML D KR T ++ W K+ + + + + Sbjct: 265 YFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKYANNINKSDQKTLCGAL 324 Query: 288 IDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASE 339 + + + + + + L + + + +L + + N E Sbjct: 325 SNMRKFEGSQKLAQAAILFIGSKLTTLEERKELTDIFKKLDKNGDGQLDKKE 376 >3DFA-A nrPDB Length = 286 Score = 316 bits (810), Expect = 2e-86, Method: Composition-based stats. Identities = 94/264 (35%), Positives = 148/264 (56%), Gaps = 10/264 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y + LG G+FG+V + ++T + AVK++N+ ++ D I RE++ LK H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDT-STILREVELLKKLDH 80 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+KL++++ + F++V E +GGELFD I K R E +A R+ +Q+ S + Y H+H Sbjct: 81 PNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKH 140 Query: 134 MVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHRDLKPEN+LL++ + KI DFGLS ++ G+ Y APEV+ G Sbjct: 141 NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-- 198 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLM 246 + D+WS GVILY LL GT PF ++ + K++ G + P++ ++ L+ Sbjct: 199 YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIR 258 Query: 247 HMLQVDPLKRATIKDIREHEWFKQ 270 ML P R T EH W ++ Sbjct: 259 KMLTFHPSLRITATQCLEHPWIQK 282 >3HDN-A nrPDB Length = 373 Score = 316 bits (810), Expect = 2e-86, Method: Composition-based stats. Identities = 104/355 (29%), Positives = 163/355 (45%), Gaps = 23/355 (6%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + K + +G G+FGKV + H+ AVK+L ++ I I E Sbjct: 32 NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV 91 Query: 68 L-KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 L K +HP ++ L+ T + V++Y++GGELF ++ + E AR +I SA Sbjct: 92 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 151 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVI 185 + Y H +V+RDLKPEN+LLD+ + + DFGL + T CG+P Y APEV+ Sbjct: 152 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 211 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 + Y VD W G +LY +L G PF + ++ I + + S LL Sbjct: 212 HKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLL 270 Query: 246 MHMLQVDPLKRATIK----DIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVKEVCEK 299 +LQ D KR K +I+ H +F L + P ++ NV ++ + Sbjct: 271 EGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 330 Query: 300 FECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASS--PPSGSFM 352 F TE V N++ G D + V + +A+E +L S PP+ SF+ Sbjct: 331 F--TEEPVPNAI--GKAPDSVLVTAS--------VKEAAEAFLGFSYAPPTDSFL 373 >5FG8-A nrPDB Length = 285 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 99/265 (37%), Positives = 147/265 (55%), Gaps = 10/265 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y + + LG G F VK + TG + A KI+N +K+ + D K++RE + + H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDF-QKLEREARICRKLHH 72 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++L+ I ++V + V+GGELF+ I E +A QQIL +V++CH++ Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 132 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRL 189 VVHRDLKPEN+LL + K+ADFGL+ + D + G+P Y +PEV+ Sbjct: 133 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEP 192 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 Y G VDIW+CGVILY LL G PF DE L+ +I+ G + P + + L+ Sbjct: 193 Y-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLI 251 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQ 270 ML V+P KR T + +H W Q Sbjct: 252 NQMLTVNPNKRITAAEALKHPWICQ 276 >5IG1-A nrPDB Length = 344 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 97/280 (34%), Positives = 151/280 (53%), Gaps = 10/280 (3%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G F V ++ TG AVK++ + +RS + + KIKREI +H HI+ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSE-INKIKREIGICSSLQHEHIVSMR 82 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + + F++V EYVSGGELFD I E +A QILSA+ +CH ++HRDL Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 141 KPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197 KPEN+LL D + KI DFGL+ +M G G+P Y +PEVI R+ VD+ Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIR-RVPYDTAVDV 201 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHMLQVDP 253 W+CGVILY LL G PF +E L+ +I+ + P + + + L+ ML+ +P Sbjct: 202 WACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPNP 261 Query: 254 LKRATIKDIREHEWF-KQDLPSYLFPEDPSYDANVIDDEA 292 +R T++++ +H W ++D+P + + + + Sbjct: 262 KRRPTVQELLQHPWIARRDVPGSVHRQATLEELKKFNARR 301 >4FG9-A nrPDB Length = 320 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 101/266 (37%), Positives = 145/266 (54%), Gaps = 10/266 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 Y D LG G F +V + E + T VA+K + ++ + + G ++ EI L + Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE--GSMENEIAVLHKIK 74 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+I+ L + + +++M+ VSGGELFD I + G E +A RL Q+L AV Y H Sbjct: 75 HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHD 134 Query: 133 HMVVHRDLKPENVL---LDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 +VHRDLKPEN+L LD I+DFGLS M G L T+CG+P Y APEV++ + Sbjct: 135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKP 194 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 Y VD WS GVI Y LLCG PF DE+ LF++I + + ++ S + Sbjct: 195 Y-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFI 253 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQD 271 H+++ DP KR T + +H W D Sbjct: 254 RHLMEKDPEKRFTCEQALQHPWIAGD 279 >2VN9-A nrPDB Length = 301 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 98/265 (36%), Positives = 148/265 (55%), Gaps = 10/265 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L + LG G F V+ TG + A KI+N +K+ + D K++RE + +L +H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDH-QKLEREARICRLLKH 62 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++L+ IS ++V + V+GGELF+ I E +A QQIL +V++CH + Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 122 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRL 189 +VHRDLKPEN+LL + K+ADFGL+ + D + G+P Y +PEV+ Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 Y G VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 183 Y-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 241 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQ 270 ML ++P KR T + +H W Q Sbjct: 242 NKMLTINPAKRITASEALKHPWICQ 266 >1FOT-A nrPDB Length = 318 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 90/303 (29%), Positives = 149/303 (49%), Gaps = 14/303 (4%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 + + + + TLG G+FG+V + + G A+K+L ++ + L V E L Sbjct: 1 PKYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLML 60 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 + HP II+++ FM+M+Y+ GGELF + K R A+ ++ A++ Sbjct: 61 SIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Y H +++RDLKPEN+LLD + + KI DFG + + D + T CG+P+Y APEV+S + Sbjct: 121 YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVVSTK 178 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248 Y +D WS G+++Y +L G PF D + ++KI P + N V LL + Sbjct: 179 PY-NKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 Query: 249 LQVDPLKRA-----TIKDIREHEWFKQDLPSYL------FPEDPSYDANVIDDEAVKEVC 297 + D +R +D++ H WFK+ + L P +P D + Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYP 297 Query: 298 EKF 300 E+ Sbjct: 298 EED 300 >2BDW-A nrPDB Length = 362 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 96/262 (36%), Positives = 148/262 (56%), Gaps = 9/262 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y + + LG G F V+ H+ TG + A KI+N +K+ + D K++RE + + +H Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDF-QKLEREARICRKLQH 87 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++L+ I + ++V + V+GGELF+ I E +A QQIL ++ YCH + Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 147 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHR+LKPEN+LL + K+ADFGL+ ++D E G+P Y +PEV+ Y Sbjct: 148 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 207 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLM 246 + P VDIW+CGVILY LL G PF DE L+ +I+ G + P + + +L+ Sbjct: 208 SKP-VDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLID 266 Query: 247 HMLQVDPLKRATIKDIREHEWF 268 ML V+P KR T + W Sbjct: 267 SMLTVNPKKRITADQALKVPWI 288 >3ZUT-A nrPDB Length = 362 Score = 308 bits (789), Expect = 4e-84, Method: Composition-based stats. Identities = 113/300 (37%), Positives = 158/300 (52%), Gaps = 12/300 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L +G G FG ++ + + VAVK + R + + +KREI N + RH Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGE----KIDENVKREIINHRSLRH 74 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V YCH Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 134 MVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 V HRDLK EN LLD KI FG S +++ G+P Y APEV+ + Y Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYD 194 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEY--LNRSVATLL 245 G D+WSCGV LY +L G PF+D P F+K I + IP+Y ++ L+ Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTES 305 + DP KR +I +IR HEWF ++LP+ L ++ D+ + + E + Sbjct: 255 SRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAE 314 >3KK8-A nrPDB Length = 284 Score = 308 bits (789), Expect = 4e-84, Method: Composition-based stats. Identities = 96/262 (36%), Positives = 148/262 (56%), Gaps = 9/262 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y + + LG G F V+ H+ TG + A KI+N +K+ + D K++RE + + +H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDF-QKLEREARICRKLQH 64 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++L+ I + ++V + V+GGELF+ I E +A QQIL ++ YCH + Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 124 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHR+LKPEN+LL + K+ADFGL+ ++D E G+P Y +PEV+ Y Sbjct: 125 GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPY 184 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLM 246 + P VDIW+CGVILY LL G PF DE L+ +I+ G + P + + +L+ Sbjct: 185 SKP-VDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLID 243 Query: 247 HMLQVDPLKRATIKDIREHEWF 268 ML V+P KR T + W Sbjct: 244 SMLTVNPKKRITADQALKVPWI 265 >3UC3-A nrPDB Length = 361 Score = 307 bits (787), Expect = 6e-84, Method: Composition-based stats. Identities = 106/309 (34%), Positives = 158/309 (51%), Gaps = 12/309 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y +G G FG ++ +LT VAVK + R ++REI N + RH Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID----ENVQREIINHRSLRH 75 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++ +VI TPT ++MEY SGGEL++ IC GR E EAR FQQ+LS V YCH Sbjct: 76 PNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 134 MVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 + HRDLK EN LLD KI DFG S +++ G+P Y APEV+ + Y Sbjct: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEY--LNRSVATLL 245 G D+WSCGV LY +L G PF+D P ++K I + IP+ ++ L+ Sbjct: 196 GKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHLI 255 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTES 305 + DP R +I +I+ H WF ++LP+ L E + ++ ++ + + Sbjct: 256 SRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQPMQSLDTIMQIISE 315 Query: 306 EVMNSLYSG 314 + ++ + Sbjct: 316 ATIPAVRNR 324 >3UDB-A nrPDB Length = 317 Score = 307 bits (786), Expect = 8e-84, Method: Composition-based stats. Identities = 114/300 (38%), Positives = 158/300 (52%), Gaps = 12/300 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L +G G FG ++ + VAVK + R + + +KREI N + RH Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGE----KIDENVKREIINHRSLRH 74 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++ +VI TPT +VMEY SGGELF+ IC GR E EAR FQQ++S V Y H Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 134 MVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 V HRDLK EN LLD KIADFG S +++ G+P Y APEV+ + Y Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYD 194 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK----IRGGVFYIPEY--LNRSVATLL 245 G D+WSCGV LY +L G PF+D P F+K I + IP+Y ++ L+ Sbjct: 195 GKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECRHLI 254 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTES 305 + DP KR +I +IR HEWF ++LP+ L ++ D+ + + E + Sbjct: 255 SRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAE 314 >2JC6-A nrPDB Length = 334 Score = 307 bits (786), Expect = 9e-84, Method: Composition-based stats. Identities = 99/263 (37%), Positives = 147/263 (55%), Gaps = 10/263 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + +TLG G F +V + E + TG AVK + ++ ++ + I+ EI L+ +H + Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE--SSIENEIAVLRKIKHEN 81 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L + +P ++VM+ VSGGELFD I + G E +A L +Q+L AV Y HR + Sbjct: 82 IVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 136 VHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 VHRDLKPEN+L D I+DFGLS M G+ + T+CG+P Y APEV++ + Y Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY-S 200 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHM 248 VD WS GVI Y LLCG PF DE+ LF++I + + ++ S + ++ Sbjct: 201 KAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNL 260 Query: 249 LQVDPLKRATIKDIREHEWFKQD 271 ++ DP KR T + H W D Sbjct: 261 MEKDPNKRYTCEQAARHPWIAGD 283 >3TXO-A nrPDB Length = 353 Score = 306 bits (784), Expect = 2e-83, Method: Composition-based stats. Identities = 105/315 (33%), Positives = 158/315 (50%), Gaps = 12/315 (3%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+ I ++ LG G+FGKV + + TG AVK+L + I D V E + L Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 78 Query: 70 LFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L R HP + +L+ TP F VME+V+GG+L +I K R +E AR +I+SA+ Sbjct: 79 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 138 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISG 187 + H +++RDLK +NVLLD + K+ADFG+ + +G T CG+P+Y APE++ Sbjct: 139 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 198 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 LY GP VD W+ GV+LY +LCG PF+ E+ LF+ I P +L+ +L Sbjct: 199 MLY-GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 257 Query: 248 MLQVDPLKRATI------KDIREHEWFKQDLPSYL--FPEDPSYDANVIDDEAVKEVCEK 299 + +P R I H +FK+ + L +P + + E V Sbjct: 258 FMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPD 317 Query: 300 FECTESEVMNSLYSG 314 F E V+ + G Sbjct: 318 F-IKEEPVLTPIDEG 331 >3BHH-A nrPDB Length = 295 Score = 305 bits (781), Expect = 4e-83, Method: Composition-based stats. Identities = 100/265 (37%), Positives = 147/265 (55%), Gaps = 10/265 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L + +G G F V+ TGH+ A KI+N +K+ + D K++RE + +L +H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDH-QKLEREARICRLLKH 62 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 +I++L+ IS ++V + V+GGELF+ I E +A QQIL AV +CH+ Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRL 189 VVHRDLKPEN+LL + K+ADFGL+ + D + G+P Y +PEV+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 Y G VDIW+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 183 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 241 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQ 270 ML ++P KR T + +H W Q Sbjct: 242 NQMLTINPAKRITAHEALKHPWVCQ 266 >2VZ6-A nrPDB Length = 313 Score = 303 bits (777), Expect = 1e-82, Method: Composition-based stats. Identities = 97/262 (37%), Positives = 147/262 (56%), Gaps = 10/262 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ L G + A KI+N +K+ + D K++RE + +L +HP+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 82 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS +++ + V+GGELF+ I E +A QQIL AV +CH+ V Sbjct: 83 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 136 VHRDLKPENVLLDAHMN---AKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + + K+ADFGL+ + + + G+P Y +PEV+ Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY- 201 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 G VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 202 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 248 MLQVDPLKRATIKDIREHEWFK 269 ML ++P KR T + +H W Sbjct: 262 MLTINPSKRITAAEALKHPWIS 283 >5U6Y-A nrPDB Length = 461 Score = 303 bits (777), Expect = 1e-82, Method: Composition-based stats. Identities = 97/262 (37%), Positives = 147/262 (56%), Gaps = 10/262 (3%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y L + LG G F V+ L G + A KI+N +K+ + D K++RE + +L +HP+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDH-QKLEREARICRLLKHPN 60 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++L+ IS +++ + V+GGELF+ I E +A QQIL AV +CH+ V Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 136 VHRDLKPENVLLDAHMN---AKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 191 VHRDLKPEN+LL + + K+ADFGL+ + + + G+P Y +PEV+ Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPY- 179 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMH 247 G VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 180 GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 248 MLQVDPLKRATIKDIREHEWFK 269 ML ++P KR T + +H W Sbjct: 240 MLTINPSKRITAAEALKHPWIS 261 >2V7O-A nrPDB Length = 336 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 95/265 (35%), Positives = 145/265 (54%), Gaps = 10/265 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L + LG G F V+ + + A KI+N +K+ + D K++RE + +L +H Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDH-QKLEREARICRLLKH 89 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++L+ IS ++V + V+GGELF+ I E +A QIL +V++ H+H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 149 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRL 189 +VHRDLKPEN+LL + K+ADFGL+ + + + G+P Y +PEV+ Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 Y G VDIW+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 210 Y-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 268 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQ 270 ML ++P KR T +H W Q Sbjct: 269 NQMLTINPAKRITADQALKHPWVCQ 293 >4UZD-A nrPDB Length = 287 Score = 302 bits (773), Expect = 3e-82, Method: Composition-based stats. Identities = 77/259 (29%), Positives = 140/259 (54%), Gaps = 2/259 (0%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + +G LG G FG V + + + +A+K+L + ++ V +++RE++ R Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+I++LY T ++++EY G ++ + K + +E ++ +A+ YCH Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 126 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 V+HRD+KPEN+LL + KIADFG S + + T CG+ +Y PE+I GR++ Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH-D 184 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 +VD+WS GV+ Y L G PF+ +K+I F P+++ L+ +L+ + Sbjct: 185 EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHN 244 Query: 253 PLKRATIKDIREHEWFKQD 271 P +R ++++ EH W + Sbjct: 245 PSQRPMLREVLEHPWITAN 263 >3D2K-A nrPDB Length = 272 Score = 301 bits (771), Expect = 5e-82, Method: Composition-based stats. Identities = 78/260 (30%), Positives = 141/260 (54%), Gaps = 2/260 (0%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 + + +G LG G FG V + + + +A+K+L + ++ V +++RE++ Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHL 69 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 RHP+I++LY T ++++EY G ++ + K R +E ++ +A+ YCH Sbjct: 70 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCH 129 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 V+HRD+KPEN+LL ++ KIADFG S + + T CG+ +Y PE+I GR++ Sbjct: 130 SKRVIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH- 187 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 251 +VD+WS GV+ Y L G PF+ +++I F P+++ L+ +L+ Sbjct: 188 DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKH 247 Query: 252 DPLKRATIKDIREHEWFKQD 271 + +R T+ ++ EH W K + Sbjct: 248 NASQRLTLAEVLEHPWIKAN 267 >3F3Z-A nrPDB Length = 277 Score = 301 bits (770), Expect = 6e-82, Method: Composition-based stats. Identities = 101/267 (37%), Positives = 149/267 (55%), Gaps = 12/267 (4%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 +Y L +T+G G++G+VKI + T + A K + + + +D + K+EI+ +K HP Sbjct: 10 YYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD---RFKQEIEIMKSLDHP 66 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +II+LY+ TD ++VME +GGELF+ + E +A R+ + +LSAV YCH+ Sbjct: 67 NIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLN 126 Query: 135 VVHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 V HRDLKPEN L K+ DFGL+ G+ +RT G+P Y +P+V+ G Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LY 184 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVATLLMH 247 GPE D WS GV++Y LLCG PF + KIR G F PE ++ +L+ Sbjct: 185 GPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRR 244 Query: 248 MLQVDPLKRATIKDIREHEWFKQDLPS 274 +L P +R T EHEWF++ L S Sbjct: 245 LLTKSPKQRITSLQALEHEWFEKQLSS 271 >5F9E-A nrPDB Length = 353 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 94/304 (30%), Positives = 147/304 (48%), Gaps = 6/304 (1%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 E+ ++KI + L LG G+FGKV + E + T A+K L + + D V Sbjct: 7 KERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECT 66 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 E + L L HP + ++ T + F VMEY++GG+L +I + + A Sbjct: 67 MVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYA 126 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNY 179 +I+ + + H +V+RDLK +N+LLD + KIADFG+ M CG+P+Y Sbjct: 127 AEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDY 186 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR 239 APE++ G+ Y VD WS GV+LY +L G PF + LF IR + P +L + Sbjct: 187 IAPEILLGQKYNH-SVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEK 245 Query: 240 SVATLLMHMLQVDPLKRATIK-DIREHEWFKQDLPSYLF--PEDPSYDANVIDDEAVKEV 296 LL+ + +P KR ++ DIR+H F++ L DP + V Sbjct: 246 EAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNF 305 Query: 297 CEKF 300 ++F Sbjct: 306 DKEF 309 >4L42-A nrPDB Length = 346 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 86/305 (28%), Positives = 141/305 (46%), Gaps = 13/305 (4%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQ---LTGHKVAVKILNRQKI-RSLDVVGKIKR 63 +++ + L LG G +GKV TG A+K+L + I R+ K Sbjct: 12 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 71 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 E L+ +HP I+ L T ++++EY+SGGELF + + G E A +I Sbjct: 72 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 131 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAP 182 A+ + H+ +++RDLKPEN++L+ + K+ DFGL + DG T CG+ Y AP Sbjct: 132 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAP 191 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVA 242 E++ + VD WS G ++Y +L G PF E+ KI +P YL + Sbjct: 192 EILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 250 Query: 243 TLLMHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVKE 295 LL +L+ + R +++ H +F+ L +P + + +E V + Sbjct: 251 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQ 310 Query: 296 VCEKF 300 KF Sbjct: 311 FDSKF 315 >4RA4-A nrPDB Length = 355 Score = 299 bits (765), Expect = 3e-81, Method: Composition-based stats. Identities = 95/287 (33%), Positives = 151/287 (52%), Gaps = 10/287 (3%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 RVK+ + LG G+FGKV + + + T A+KIL + + D V E + L Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 70 LFRHP-HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L P + +L+ T + VMEYV+GG+L +I + G+ +E +A +I + Sbjct: 76 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISG 187 + H+ +++RDLK +NV+LD+ + KIADFG+ M DG RT CG+P+Y APE+I+ Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY 195 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + Y G VD W+ GV+LY +L G PFD E LF+ I P+ L++ ++ Sbjct: 196 QPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKG 254 Query: 248 MLQVDPLKRATI-----KDIREHEWFKQDLPSYLFPED--PSYDANV 287 ++ P KR +D+REH +F++ L + P + V Sbjct: 255 LMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKV 301 >3SOA-A nrPDB Length = 444 Score = 296 bits (758), Expect = 2e-80, Method: Composition-based stats. Identities = 95/264 (35%), Positives = 146/264 (55%), Gaps = 10/264 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L + LG G F V+ L G + A I+N +K+ + D K++RE + +L +H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDH-QKLEREARICRLLKH 69 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I++L+ IS +++ + V+GGELF+ I E +A QQIL AV +CH+ Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 189 VVHR+LKPEN+LL + + K+ADFGL+ + + + G+P Y +PEV+ Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLL 245 Y G VD+W+CGVILY LL G PF DE L+++I+ G + P + + L+ Sbjct: 190 Y-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248 Query: 246 MHMLQVDPLKRATIKDIREHEWFK 269 ML ++P KR T + +H W Sbjct: 249 NKMLTINPSKRITAAEALKHPWIS 272 >4JXF-A nrPDB Length = 266 Score = 295 bits (756), Expect = 3e-80, Method: Composition-based stats. Identities = 84/262 (32%), Positives = 141/262 (53%), Gaps = 3/262 (1%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 KI + +G+ LG G+F V E TG +VA+K+++++ + +V +++ E++ Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYC 130 +HP I++LY ++V+E GE+ Y+ E EAR QI++ + Y Sbjct: 65 KHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRL 189 H H ++HRDL N+LL +MN KIADFGL+ + E T CG+PNY +PE I+ R Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRS 183 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHML 249 G E D+WS G + Y LL G PFD + V K+ + +P +L+ L+ +L Sbjct: 184 AHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLL 243 Query: 250 QVDPLKRATIKDIREHEWFKQD 271 + +P R ++ + +H + ++ Sbjct: 244 RRNPADRLSLSSVLDHPFMSRN 265 >5XZW-A nrPDB Length = 471 Score = 294 bits (753), Expect = 7e-80, Method: Composition-based stats. Identities = 92/270 (34%), Positives = 144/270 (53%), Gaps = 20/270 (7%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 ++ + +G G F VK + TG AVKI++++K+ + + + RE++ L+ HP I Sbjct: 199 IIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKV--IGNMDGVTRELEVLQKLNHPRI 256 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 ++L ++MVME+VSGG+L D++ HG V E R + +QIL+A+ Y H + Sbjct: 257 VRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 137 HRDLKPENVLL--DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG------- 187 HRDLKP+N+L+ D + KI DFGL+ + +G F++T CG+ Y APEVI G Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 188 -----RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY----IPEYLN 238 R VD+WS G ++Y +L G LPF L+K+I G ++ ++ Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 436 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + +LQVDP R+T H W Sbjct: 437 EEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >5D9K-A nrPDB Length = 330 Score = 294 bits (752), Expect = 8e-80, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 151/309 (48%), Gaps = 16/309 (5%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTG----HKVAVKILNRQKIRSLDVVG 59 K+ H+ + + L LG G+FGKV + + +++G A+K+L + ++ D V Sbjct: 21 KEGHE-KADPSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV- 77 Query: 60 KIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL 119 + K E L HP I+KL+ T +++++++ GG+LF + K E + + Sbjct: 78 RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 137 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSPN 178 ++ A+D+ H +++RDLKPEN+LLD + K+ DFGLS D E + CG+ Sbjct: 138 LAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVE 197 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Y APEV++ R + D WS GV+++ +L GTLPF + I +P++L+ Sbjct: 198 YMAPEVVNRRGHT-QSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLS 256 Query: 239 RSVATLLMHMLQVDPLKRATI-----KDIREHEWFKQDLPSYLFPED--PSYDANVIDDE 291 +LL + + +P R ++I+ H +F + L+ + P + E Sbjct: 257 PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPE 316 Query: 292 AVKEVCEKF 300 +F Sbjct: 317 DTFYFDPEF 325 >4RLP-A nrPDB Length = 288 Score = 294 bits (752), Expect = 9e-80, Method: Composition-based stats. Identities = 82/288 (28%), Positives = 134/288 (46%), Gaps = 13/288 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQ---LTGHKVAVKILNRQKI-RSLDVVGKIKREI 65 +++ + L LG G +GKV TG A+K+L + I R+ K E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 L+ +HP I+ L T ++++EY+SGGELF + + G E A +I Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEV 184 A+ + H+ +++RDLKPEN++L+ + K+ DFGL + DG T CG+ Y APE+ Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 180 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL 244 + + VD WS G ++Y +L G PF E+ KI +P YL + L Sbjct: 181 LMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDL 239 Query: 245 LMHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPE--DPSYDA 285 L +L+ + R +++ H +F+ L +P + Sbjct: 240 LKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >4CSV-A nrPDB Length = 275 Score = 293 bits (751), Expect = 1e-79, Method: Composition-based stats. Identities = 72/276 (26%), Positives = 127/276 (46%), Gaps = 13/276 (4%) Query: 6 KHD-GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 HD + L LG G FG+V G+ + +VAVK L + V + +E Sbjct: 2 PHDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQE 57 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQ 122 Q +K +HP++++LY V + +++ EY+S G L DY+ C+ V + Q Sbjct: 58 AQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQ 117 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYA 180 + S + Y +HRDL N L+ + K+ADFGL+ ++++ E+ R P + Sbjct: 118 VASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWT 177 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLN 238 APE IS + + D+W+ G++L+ + G +P+ + +++ RG P+ Sbjct: 178 APEAISYNRF-SIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP 236 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 + L++ P +R T + H LP Sbjct: 237 EEIYELMLQCWNKSPEERPTFAETL-HALETMFLPE 271 >2W4O-A nrPDB Length = 349 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 98/287 (34%), Positives = 149/287 (51%), Gaps = 14/287 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + + LG G V + + T A+K+L + + + ++ EI L H Sbjct: 53 DFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKI-----VRTEIGVLLRLSH 107 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+IIKL ++ TPT+ +V+E V+GGELFD I + G E +A +QIL AV Y H + Sbjct: 108 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 167 Query: 134 MVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 +VHRDLKPEN+L KIADFGLS ++ ++T CG+P Y APE++ G Y Sbjct: 168 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 227 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPT-LFKKIRGGVFYI--P--EYLNRSVATLL 245 GPEVD+WS G+I Y LLCG PF DE +F++I +Y P + ++ + L+ Sbjct: 228 -GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLV 286 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEA 292 ++ +DP KR T +H W +++ + + Sbjct: 287 RKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARR 333 >2JAM-A nrPDB Length = 304 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 96/260 (36%), Positives = 144/260 (55%), Gaps = 12/260 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++ + LG G F +V + + +LTG A+K + + ++ EI LK +H + Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKS---PAFRDSSLENEIAVLKKIKHEN 67 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I+ L + + T +++VM+ VSGGELFD I + G E +A + QQ+LSAV Y H + + Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGI 127 Query: 136 VHRDLKPENVLL---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 VHRDLKPEN+L + + I DFGLS M + T+CG+P Y APEV++ + Y Sbjct: 128 VHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPY-S 185 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP----EYLNRSVATLLMHM 248 VD WS GVI Y LLCG PF +E LF+KI+ G + + ++ S + H+ Sbjct: 186 KAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHL 245 Query: 249 LQVDPLKRATIKDIREHEWF 268 L+ DP +R T + H W Sbjct: 246 LEKDPNERYTCEKALSHPWI 265 >2J90-A nrPDB Length = 304 Score = 291 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 88/280 (31%), Positives = 139/280 (49%), Gaps = 12/280 (4%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--- 57 + + + + HY +G+ LG G F V+ + TG + A K + ++++ S Sbjct: 13 LGTENLYFQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVS 72 Query: 58 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 117 +I+RE+ L+ RHP+II L+ + TD +++E VSGGELFD++ + + E EA Sbjct: 73 REEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEAT 132 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDA----HMNAKIADFGLSNMMSDGEFLRTS 173 + +QIL V Y H + H DLKPEN++L + K+ DFG+++ + G + Sbjct: 133 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 192 Query: 174 CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI 233 G+P + APE+++ G E D+WS GVI Y LL G PF E I + Sbjct: 193 FGTPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDF 251 Query: 234 PE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 E + + +L DP +R TI EH W K Sbjct: 252 DEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >5FET-A nrPDB Length = 847 Score = 291 bits (744), Expect = 8e-79, Method: Composition-based stats. Identities = 105/315 (33%), Positives = 160/315 (50%), Gaps = 16/315 (5%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 + D +V++ +G GTFG VK+ H+ T + A+K ++++ I SL+ IK E Sbjct: 524 KMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLE 583 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 + HP II+L + F+ + E V+GGEL+D I K G + + +A+ I+ Sbjct: 584 REITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSII 643 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 A++Y H +V+RDLKPEN+LLD K+ DFG + + + T G+P+Y APEV Sbjct: 644 LAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAY--TLVGTPHYMAPEV 701 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRGGVFYIPEYLN-RSV 241 I G+ Y G VDIW+ GV LY +CG LPF D E +F+ I G P+Y++ + Sbjct: 702 ILGKGY-GCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDS 760 Query: 242 ATLLMHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLF-----PEDPSYDANVIDDE 291 L+ +L P R KDI+EH +F L P S +D Sbjct: 761 INLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDI 820 Query: 292 AVKEVCEKFECTESE 306 +K++ E+ E E Sbjct: 821 DIKQIEEEDALNEGE 835 >2YCR-A nrPDB Length = 323 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 99/278 (35%), Positives = 147/278 (52%), Gaps = 16/278 (5%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI-----RSLDVVGKIKR 63 + Y++ TLG G G+VK+ + T KVA+KI++++K R D ++ Sbjct: 5 PKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET 64 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 EI+ LK HP IIK+ D+++V+E + GGELFD + + R++E + F Q+ Sbjct: 65 EIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM 123 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 L AV Y H + ++HRDLKPENVLL KI DFG S ++ + +RT CG+P Y Sbjct: 124 LLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYL 183 Query: 181 APEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT-LFKKIRGGVF-YIPE- 235 APEV+ G VD WS GVIL+ L G PF + L +I G + +IPE Sbjct: 184 APEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEV 243 Query: 236 --YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 ++ L+ +L VDP R T ++ H W + + Sbjct: 244 WAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE 281 >1PHK-A nrPDB Length = 298 Score = 289 bits (741), Expect = 2e-78, Method: Composition-based stats. Identities = 95/273 (34%), Positives = 142/273 (52%), Gaps = 16/273 (5%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR------QKIRSLDVVGKIKREIQN 67 +Y + LG G V+ H+ T + AVKI++ ++ +E+ Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 68 LKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 L+ HP+II+L T T FF+V + + GELFDY+ + + E E R++ + +L Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + H+ +VHRDLKPEN+LLD MN K+ DFG S + GE LR CG+P+Y APE+I Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIE 196 Query: 187 -----GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--L 237 G EVD+WS GVI+Y LL G+ PF + + I G + PE+ Sbjct: 197 CSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDY 256 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + +V L+ L V P KR T ++ H +F+Q Sbjct: 257 SDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >3I6U-A nrPDB Length = 419 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 99/284 (34%), Positives = 149/284 (52%), Gaps = 16/284 (5%) Query: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI-----RSLDV 57 + Q + Y++ TLG G G+VK+ + T KVA++I++++K R D Sbjct: 124 DDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADP 183 Query: 58 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR 117 ++ EI+ LK HP IIK+ D+++V+E + GGELFD + + R++E + Sbjct: 184 ALNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVVGNKRLKEATCK 242 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSC 174 F Q+L AV Y H + ++HRDLKPENVLL KI DFG S ++ + +RT C Sbjct: 243 LYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC 302 Query: 175 GSPNYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT-LFKKIRGGVF 231 G+P Y APEV+ G VD WS GVIL+ L G PF + L +I G + Sbjct: 303 GTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKY 362 Query: 232 -YIPE---YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 +IPE ++ L+ +L VDP R T ++ H W + + Sbjct: 363 NFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE 406 >2Z7Q-A nrPDB Length = 321 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 144/295 (48%), Gaps = 13/295 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQ---LTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 H+ L LG G+FGKV + +GH A+K+L + ++ D V + K E L Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILAD 86 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 HP ++KL+ T +++++++ GG+LF + K E + + ++ +D+ Sbjct: 87 VNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHL 146 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSPNYAAPEVISGRL 189 H +++RDLKPEN+LLD + K+ DFGLS D E + CG+ Y APEV++ + Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 206 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHML 249 ++ D WS GV+++ +L G+LPF + I +P++L+ +LL + Sbjct: 207 HSH-SADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALF 265 Query: 250 QVDPLKRA-----TIKDIREHEWFKQDLPSYLFPED--PSYDANVIDDEAVKEVC 297 + +P R ++I+ H ++ + L+ + P + V + Sbjct: 266 KRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 320 >3PFQ-A nrPDB Length = 674 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 93/293 (31%), Positives = 148/293 (50%), Gaps = 10/293 (3%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 70 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 397 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISG 187 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 516 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 517 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 575 Query: 248 MLQVDPLKRATI-----KDIREHEWFKQDLPSYLFPED--PSYDANVIDDEAV 293 ++ P KR +DI+EH +F+ L ++ P Y A Sbjct: 576 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRNAE 628 >5N23-A nrPDB Length = 352 Score = 288 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 94/299 (31%), Positives = 156/299 (52%), Gaps = 17/299 (5%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 P ++KL ++ +MV+EY GGE+F ++ + GR E AR QI+ +Y H Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 +++RDLKPEN+L+D K+ADFG + + G T CG+P Y APE+I + Y Sbjct: 161 LDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK-GRTPWTLCGTPEYLAPEIILSKGY-N 218 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 VD W+ GV++Y + G PF + +++KI G P + + + LL ++LQVD Sbjct: 219 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 278 Query: 253 PLKRA-----TIKDIREHEWF---------KQDLPSYLFPEDP-SYDANVIDDEAVKEV 296 KR + DI+ H+WF ++ + + P+ D + DD +E+ Sbjct: 279 LTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 337 >5DYK-A nrPDB Length = 853 Score = 288 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 97/301 (32%), Positives = 151/301 (50%), Gaps = 17/301 (5%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 + D +V++ +G GTFG VK+ H+ T + A+K ++++ I +L+ IK E Sbjct: 530 KMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLE 589 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 + HP II+L + F+ + E V+GGEL+D I K G + + +A+ I+ Sbjct: 590 REITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSII 649 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 A++Y H +V+RDLKPEN+LLD K+ DFG + + + T G+P+Y APEV Sbjct: 650 LAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAY--TLVGTPHYMAPEV 707 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRGGVFYIPEYLNR-SV 241 I G+ Y G VDIW+ G+ LY +CG LPF D+E +F+ I G P+Y+ Sbjct: 708 ILGKGY-GCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDS 766 Query: 242 ATLLMHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYL------FPEDPSYDANVIDD 290 L+ +L P R KDI++H +F L P + D Sbjct: 767 INLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDI 826 Query: 291 E 291 + Sbjct: 827 D 827 >3DB8-A nrPDB Length = 317 Score = 288 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 82/269 (30%), Positives = 128/269 (47%), Gaps = 2/269 (0%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 + Y+ G LG G F K T A K++ + + K+ EI K Sbjct: 40 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL 99 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 +PH++ + ++V+E L + + V E EAR +Q + V Y H Sbjct: 100 DNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLH 159 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLY 190 + V+HRDLK N+ L+ M+ KI DFGL+ + DGE + CG+PNY APEV+ + + Sbjct: 160 NNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGH 219 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 EVDIWS G ILY LL G PF+ + + +I+ + +P ++N + L+ ML Sbjct: 220 -SFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLH 278 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPE 279 DP R ++ ++ E+F P Sbjct: 279 ADPTLRPSVAELLTDEFFTSGYAPMRLPT 307 >3COM-A nrPDB Length = 314 Score = 288 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 76/259 (29%), Positives = 124/259 (47%), Gaps = 11/259 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + + + LG G++G V H+ TG VA+K + + + +I +EI ++ PH Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE-----SDLQEIIKEISIMQQCDSPH 85 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDYCHRHM 134 ++K Y TD ++VMEY G + D I ++ + E E + Q L ++Y H Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 145 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGP 193 +HRD+K N+LL+ +AK+ADFG++ ++D R T G+P + APEVI Y Sbjct: 146 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY-NC 204 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQ 250 DIWS G+ + G P+ D H I F PE + + + L Sbjct: 205 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 264 Query: 251 VDPLKRATIKDIREHEWFK 269 P +RAT + +H + + Sbjct: 265 KSPEQRATATQLLQHPFVR 283 >2I0E-A nrPDB Length = 353 Score = 288 bits (736), Expect = 7e-78, Method: Composition-based stats. Identities = 93/293 (31%), Positives = 148/293 (50%), Gaps = 10/293 (3%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+K+ + LG G+FGKV + E + T AVKIL + + D V E + L Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 70 L-FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 L + P + +L+ T + VMEYV+GG+L +I + GR +E A +I + Sbjct: 76 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISG 187 + +++RDLK +NV+LD+ + KIADFG+ + DG +T CG+P+Y APE+I+ Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAY 195 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMH 247 + Y G VD W+ GV+LY +L G PF+ E LF+ I P+ +++ + Sbjct: 196 QPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKG 254 Query: 248 MLQVDPLKRATI-----KDIREHEWFKQDLPSYLFPED--PSYDANVIDDEAV 293 ++ P KR +DI+EH +F+ L ++ P Y A Sbjct: 255 LMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAE 307 >5X3F-B nrPDB Length = 393 Score = 287 bits (735), Expect = 9e-78, Method: Composition-based stats. Identities = 93/300 (31%), Positives = 158/300 (52%), Gaps = 18/300 (6%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 ++ + TLG G+FG+V + +H+ +G+ A+KIL++QK+ L + E + L+ Sbjct: 82 QLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 141 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P ++KL ++ +MVMEYV+GGE+F ++ + GR E AR QI+ +Y H Sbjct: 142 NFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 201 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +++RDLKPEN+L+D ++ DFG + + T CG+P Y APE+I + Y Sbjct: 202 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGY- 258 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQV 251 VD W+ GV++Y + G PF + +++KI G P + + + LL ++LQV Sbjct: 259 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 318 Query: 252 DPLKRA-----TIKDIREHEWF---------KQDLPSYLFPEDP-SYDANVIDDEAVKEV 296 D KR + DI+ H+WF ++ + + P+ D + DD +E+ Sbjct: 319 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEI 378 >6E9W-A nrPDB Length = 443 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 95/362 (26%), Positives = 159/362 (43%), Gaps = 24/362 (6%) Query: 2 AEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKI 61 + D R+K Y + +G G FG+V++ H+ T A+K+L++ ++ Sbjct: 90 TINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFF 149 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 E + P +++L+ +MVMEY+ GG+L + + + V E AR Sbjct: 150 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTA 208 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNY 179 +++ A+D H +HRD+KP+N+LLD + K+ADFG M+ +R T+ G+P+Y Sbjct: 209 EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY 268 Query: 180 AAPEVIS---GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--FYIP 234 +PEV+ G Y G E D WS GV LY +L G PF + + + KI P Sbjct: 269 ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 328 Query: 235 E--YLNRSVATLLMHMLQVDPLKRA---TIKDIREHEWFKQD--LPSYLFPEDPSYDANV 287 + +++ L+ L D R +++I+ H +FK D L ++ Sbjct: 329 DDNDISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 387 Query: 288 IDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPP 347 D + E E + +QL NRR YL+S+ P Sbjct: 388 SSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRR--------YLSSANP 439 Query: 348 SG 349 + Sbjct: 440 ND 441 >4WB7-A nrPDB Length = 405 Score = 286 bits (732), Expect = 2e-77, Method: Composition-based stats. Identities = 89/262 (33%), Positives = 143/262 (54%), Gaps = 8/262 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + TLG G+FG+V + +H+ TG+ A+KIL++QK+ L + E + L+ Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 P ++KL ++ +MVMEYV GGE+F ++ + GR E AR QI+ +Y H Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 214 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 +++RDLKPEN+L+D ++ DFG + + T CG+P Y APE+I + Y Sbjct: 215 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLAPEIILSKGY-N 271 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVD 252 VD W+ GV++Y + G PF + +++KI G P + + + LL ++LQVD Sbjct: 272 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVD 331 Query: 253 PLKRA-----TIKDIREHEWFK 269 KR + DI+ H+WF Sbjct: 332 LTKRFGNLKNGVNDIKNHKWFA 353 >4PDS-A nrPDB Length = 347 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 91/271 (33%), Positives = 144/271 (53%), Gaps = 20/271 (7%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 ++ + +G G F VK + TG +VKI++++K+ + + + RE++ L+ HP I Sbjct: 34 IIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKV--IGNMDGVTRELEVLQKLNHPRI 91 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 ++L ++MVME+VSGG+L D++ HG V E R + +QIL+A+ Y H + Sbjct: 92 VRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 137 HRDLKPENVLL--DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG------- 187 HRDLKP+N+L+ D + KI FGL+ + +G F++T CG+ Y APEVI G Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 188 -----RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY----IPEYLN 238 R VD+WS G ++Y +L G LPF L+K+I G ++ ++ Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRIS 271 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + +LQVDP R+T H W K Sbjct: 272 EEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >5JZN-A nrPDB Length = 280 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 95/267 (35%), Positives = 144/267 (53%), Gaps = 15/267 (5%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y +G T+G G F VK + T + A+KI+ + K R + + I+ E+ L+ +H Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM--IQNEVSILRRVKH 76 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+ L + + PT+ ++VME V GG+LFD I + E +A + + SA+ Y H Sbjct: 77 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 136 Query: 134 MVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 +VHRD+KPEN+L+ D + K+ DFGL+ ++ L T CG+P Y APE+I+ Sbjct: 137 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAETG 194 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRGGVFYIP----EYLNRSVAT 243 Y G +VDIW+ GVI Y LLCG PF + LF +I G P + ++ S Sbjct: 195 Y-GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKE 253 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQ 270 L+ ML VD +R + + EH W Sbjct: 254 LITMMLLVDVDQRFSAVQVLEHPWVND 280 >4B6L-A nrPDB Length = 281 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 80/264 (30%), Positives = 130/264 (49%), Gaps = 2/264 (0%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y+ G LG G F + TG AVK++ + ++ KI EI+ + +H H Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I++ + ++ +E S L + E E R +QILS + Y H+ + Sbjct: 71 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 130 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVISGRLYAGPE 194 +HRDLK N + +M K+ DFGL+ + E +T CG+PNY APEV+ + + GPE Sbjct: 131 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-GPE 189 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPL 254 D+WS G ++Y LLCG+ PF+ + ++ I+ + +P L+ LL +L+ P Sbjct: 190 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 249 Query: 255 KRATIKDIREHEWFKQDLPSYLFP 278 R +I I H++F + P Sbjct: 250 DRPSIDQILRHDFFTKGYTPDRLP 273 >4B8L-A nrPDB Length = 286 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 85/277 (30%), Positives = 143/277 (51%), Gaps = 4/277 (1%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 +AE K + I + +G LG G FG V + + +A+K+L + ++ V + Sbjct: 4 LAEMPKR--KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQ 61 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 ++REI+ RHP+I+++Y ++++E+ GEL+ + KHGR +E + Sbjct: 62 LRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFM 121 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 +++ A+ YCH V+HRD+KPEN+L+ KIADFG S + + RT CG+ +Y Sbjct: 122 EELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYL 180 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 240 PE+I G+ + +VD+W GV+ Y L G PFD ++I P +L+ Sbjct: 181 PPEMIEGKTH-DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDG 239 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLF 277 L+ +L+ P +R +K + EH W K + L Sbjct: 240 SKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLP 276 >6CMJ-A nrPDB Length = 321 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 85/287 (29%), Positives = 151/287 (52%), Gaps = 16/287 (5%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK--------IRSLDVVGKIK 62 V++ Y L D +G G++G VK+ ++ A+K+L+++K I+ + ++ Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 63 REIQNLKLFRHPHIIKLYQVISTP--TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 +EI LK HP+++KL +V+ P +MV E V+ G + + + + E +AR F Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSEDQARFYF 149 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-FLRTSCGSPNY 179 Q ++ ++Y H ++HRD+KP N+L+ + KIADFG+SN + L + G+P + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 180 AAPEVISG--RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE-- 235 APE +S ++++G +D+W+ GV LY + G PF DE + L KI+ P+ Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQP 269 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPS 282 + + L+ ML +P R + +I+ H W + L ED + Sbjct: 270 DIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDEN 316 >1VZO-A nrPDB Length = 355 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 85/312 (27%), Positives = 149/312 (47%), Gaps = 23/312 (7%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEH---QLTGHKVAVKILNRQKI-RSLDVVGKI 61 H +V I ++ L LG G +GKV + TG A+K+L + I + Sbjct: 46 GHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHT 105 Query: 62 KREIQNLKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + E Q L+ R P ++ L+ T T ++++Y++GGELF ++ + R E E + Sbjct: 106 RTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYV 165 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSPN 178 +I+ A+++ H+ +++RD+K EN+LLD++ + + DFGLS + E CG+ Sbjct: 166 GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIE 225 Query: 179 YAAPEVIS-GRLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYI 233 Y AP+++ G VD WS GV++Y LL G PF + + ++I Sbjct: 226 YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPY 285 Query: 234 PEYLNRSVATLLMHMLQVDPLKRA-----TIKDIREHEWFKQ----DLPSYLFPEDPSYD 284 P+ ++ L+ +L DP KR +I+EH +F++ DL + P + Sbjct: 286 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVP--APFK 343 Query: 285 ANVIDDEAVKEV 296 + D+ V Sbjct: 344 PVIRDELDVSNF 355 >5LOH-A nrPDB Length = 341 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 90/297 (30%), Positives = 153/297 (51%), Gaps = 13/297 (4%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 I + + + G FGKV +G Q G AVK++ + + + ++ +++ E L L + Sbjct: 35 IEEFSIVKPISRGAFGKVYLG--QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 P I+ LY + + + ++VMEY+ GG++ + +G +E A + ++ A+DY HR Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNM-------MSDGEFLRTSCGSPNYAAPEVI 185 H ++HRDLKP+N+L+ + K+ DFGLS + M D RT CG+P+Y APE++ Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP---EYLNRSVA 242 GR + GP VD W+ GV L+ L G PF+DE +F+ I P E L+ + Sbjct: 213 LGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQ 271 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEK 299 + + +L +D KRA +K+++ H F L + + D+ + Sbjct: 272 SAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEAR 328 >4LG4-A nrPDB Length = 299 Score = 284 bits (728), Expect = 5e-77, Method: Composition-based stats. Identities = 74/263 (28%), Positives = 125/263 (47%), Gaps = 11/263 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + + + LG G++G V H+ +G VA+K + + + +I +EI ++ P+ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE-----SDLQEIIKEISIMQQCDSPY 67 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDYCHRHM 134 ++K Y TD ++VMEY G + D I ++ + E E + + L ++Y H Sbjct: 68 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 127 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGP 193 +HR++K N+LL+ +AK+ADFG++ ++D R T G+P + APEVI Y Sbjct: 128 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY-NC 186 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQ 250 DIWS G+ + G P+ D H I F PE + + L Sbjct: 187 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 246 Query: 251 VDPLKRATIKDIREHEWFKQDLP 273 +P +RAT + +H + K P Sbjct: 247 KNPEQRATATQLLQHPFIKNAKP 269 >2BPM-A nrPDB Length = 309 Score = 284 bits (728), Expect = 6e-77, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 129/297 (43%), Gaps = 34/297 (11%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V + ++ + +G GT+G V ++LTG VA+K + + V REI LK Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKE 62 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVD 128 HP+I+KL VI T ++V E++ +L ++ + + Q+L + Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISG 187 +CH H V+HRDLKP+N+L++ K+ADFGL+ + Y APE++ G Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 181 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEH-VPTLFKKIRG----------GVFYIPEY 236 Y VDIWS G I ++ F + + LF+ R GV +P+Y Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 241 Query: 237 ------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSY 275 L+ +LL ML DP KR + K H +F+ Sbjct: 242 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 298 >6FDY-U nrPDB Length = 276 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 88/266 (33%), Positives = 134/266 (50%), Gaps = 8/266 (3%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGE-HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 G ++ ++L + LG GT+ V + T VA+K + ++ + V + EI+ Sbjct: 6 GPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKAS-VENLLTEIEI 64 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 LK RHPHI++L + +++ME+ +GG+L +I + E AR QQ+ SA+ Sbjct: 65 LKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASAL 124 Query: 128 DYCHRHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + H + H DLKP+N+LL + K+ADFG + MS + GSP Y APE++ Sbjct: 125 QFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV 184 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV---FYIPEYLNRSVA 242 R Y VD+WS GVILY L G PF L +KIR + L+R Sbjct: 185 CQRQY-DARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCR 243 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWF 268 LL +L+ DP +R + +D H W Sbjct: 244 DLLQRLLERDPSRRISFQDFFAHPWV 269 >4I6B-A nrPDB Length = 308 Score = 283 bits (724), Expect = 2e-76, Method: Composition-based stats. Identities = 77/257 (29%), Positives = 128/257 (49%), Gaps = 2/257 (0%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y G TLG G F K A KI+ ++ KI +EI+ ++ H Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 H+++ Y + ++++EY S + + + E E R +QI+S + Y H Sbjct: 89 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 148 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVISGRLYAGP 193 ++HRDLK N ++ M K+ DFGL+ + E RT CG+PNY +PEV++ + + G Sbjct: 149 ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH-GA 207 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDP 253 E DIW+ G ++Y +L G PF+ ++ ++ IR + +P L L+ ML +P Sbjct: 208 ESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNP 267 Query: 254 LKRATIKDIREHEWFKQ 270 R ++ DI H++F Q Sbjct: 268 EDRPSLDDIIRHDFFTQ 284 >6ED6-A nrPDB Length = 415 Score = 282 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 91/331 (27%), Positives = 155/331 (46%), Gaps = 25/331 (7%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 K+ ++K Y + +G G FG+V++ H+ + A+K+L++ ++ Sbjct: 78 KKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWE 137 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 E + P +++L+ +MVMEY+ GG+L + + + V E A+ ++ Sbjct: 138 ERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEV 196 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNYAA 181 + A+D H ++HRD+KP+N+LLD H + K+ADFG M + + T+ G+P+Y + Sbjct: 197 VLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYIS 256 Query: 182 PEVIS---GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--FYIPEY 236 PEV+ G + G E D WS GV LY +L G PF + + + KI PE Sbjct: 257 PEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPED 316 Query: 237 --LNRSVATLLMHMLQVDPLKRA---TIKDIREHEWFKQD------LPSYLFPEDPSY-- 283 +++ L+ L D R +++IR+H +FK D + P P Sbjct: 317 AEISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSS 375 Query: 284 ---DANVIDDEAVKEVCEKFECTESEVMNSL 311 +N D E K E F ++ V N L Sbjct: 376 DIDSSNFDDIEDDKGDVETFPIPKAFVGNQL 406 >2YAB-A nrPDB Length = 361 Score = 282 bits (721), Expect = 3e-76, Method: Composition-based stats. Identities = 86/267 (32%), Positives = 133/267 (49%), Gaps = 12/267 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV---VGKIKREIQNLKL 70 Y +G+ LG G F VK + TG + A K + +++ R+ +I+RE+ L+ Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQ 71 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 HP+II L+ V TD +++E VSGGELFD++ + + E EA +QIL V+Y Sbjct: 72 VLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 131 HRHMVVHRDLKPENVLLDAHM----NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + H DLKPEN++L + K+ DFGL++ + DG + G+P + APE+++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL----NRSVA 242 G E D+WS GVI Y LL G PF + I + E + Sbjct: 192 YEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAK 250 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK 269 + +L + KR TI++ H W Sbjct: 251 DFIRKLLVKETRKRLTIQEALRHPWIT 277 >2OU7-A nrPDB Length = 335 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 89/284 (31%), Positives = 137/284 (48%), Gaps = 9/284 (3%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G F K T A KI+ + + K+ EI + H H++ + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 F+V+E L + + + E EAR +QI+ Y HR+ V+HRDLK Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 168 Query: 142 PENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 N+ L+ + KI DFGL+ + DGE + CG+PNY APEV+S + + EVD+WS Sbjct: 169 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVWSI 227 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 G I+Y LL G PF+ + + +I+ + IP+++N A+L+ MLQ DP R TI Sbjct: 228 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 287 Query: 261 DIREHEWFKQ-DLPSYLF------PEDPSYDANVIDDEAVKEVC 297 ++ E+F +P+ L P S + +D K + Sbjct: 288 ELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLT 331 >4NIF-A nrPDB Length = 333 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 99/335 (29%), Positives = 156/335 (46%), Gaps = 34/335 (10%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KLFR 72 YV+ +T+GVG++ + K H+ T + AVK++++ K + EI+ L + + Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEILLRYGQ 60 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+II L V ++V E + GGEL D I + E EA + I V+Y H Sbjct: 61 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 120 Query: 133 HMVVHRDLKPENVL-LDAHMN---AKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISG 187 VVHRDLKP N+L +D N +I DFG + + ++ L T C + N+ APEV+ Sbjct: 121 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 180 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIP----EYLNRS 240 + Y DIWS G++LY +L G PF + + +I G F + ++ + Sbjct: 181 QGY-DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSET 239 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 300 L+ ML VDP +R T K + +H W Q P+ + + ++ V Sbjct: 240 AKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ---KDKLPQSQ------LSHQDLQLVKGAM 290 Query: 301 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMN 335 T ++L S P QL I+ RR+ Sbjct: 291 AATY----SALNSSKPTPQLKPIESSILAQRRVRK 321 >3GUB-A nrPDB Length = 295 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 87/268 (32%), Positives = 134/268 (50%), Gaps = 12/268 (4%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV---VGKIKREIQNLK 69 +Y G+ LG G F VK + TG + A K + +++ +S I+RE+ LK Sbjct: 10 DDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 +HP++I L++V TD ++ E V+GGELFD++ + + E EA +QIL+ V Y Sbjct: 70 EIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYY 129 Query: 130 CHRHMVVHRDLKPENVLLDAHM----NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 H + H DLKPEN++L KI DFGL++ + G + G+P + APE++ Sbjct: 130 LHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIV 189 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSV 241 + G E D+WS GVI Y LL G PF + + + + + Sbjct: 190 NYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFK 269 + +L DP KR TI+D +H W K Sbjct: 249 KDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >3ORZ-A nrPDB Length = 316 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 78/278 (28%), Positives = 130/278 (46%), Gaps = 10/278 (3%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + G LG G+F V + T + A+KIL ++ I + V + RE + H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P +KLY + + Y GEL YI K G +E R +I+SA++Y H Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPNYAAPEVISGRLY 190 ++HRDLKPEN+LL+ M+ +I DFG + ++S + G+ Y +PE+++ + Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 216 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 D+W+ G I+Y L+ G PF + +F+KI + PE L+ +L Sbjct: 217 C-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 275 Query: 251 VDPLKRATIKD------IREHEWFKQDLPSYLFPEDPS 282 +D KR ++ ++ H +F+ L + P Sbjct: 276 LDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 313 >2Y7J-A nrPDB Length = 365 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 98/271 (36%), Positives = 146/271 (53%), Gaps = 15/271 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKIL-----NRQKIRSLDVVGKIKREIQNLK 69 Y D +G G V+ H+ TGH+ AVKI+ + +V +RE L+ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 70 LF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 HPHII L + + F+V + + GELFDY+ + + E E R + + +L AV Sbjct: 155 QVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS 214 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI--- 185 + H + +VHRDLKPEN+LLD +M +++DFG S + GE LR CG+P Y APE++ Sbjct: 215 FLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCS 274 Query: 186 --SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEYLNRS- 240 G EVD+W+CGVIL+ LL G+ PF + + I G + PE+ +RS Sbjct: 275 MDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSS 334 Query: 241 -VATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 V L+ +LQVDP R T + +H +F++ Sbjct: 335 TVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >6AO5-A nrPDB Length = 362 Score = 281 bits (719), Expect = 5e-76, Method: Composition-based stats. Identities = 74/263 (28%), Positives = 125/263 (47%), Gaps = 11/263 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + + + LG G++G V H+ +G VA+K + + + +I +EI ++ P+ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE-----SDLQEIIKEISIMQQCDSPY 66 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDYCHRHM 134 ++K Y TD ++VMEY G + D I ++ + E E + + L ++Y H Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 126 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGP 193 +HR++K N+LL+ +AK+ADFG++ ++D R T G+P + APEVI Y Sbjct: 127 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY-NC 185 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQ 250 DIWS G+ + G P+ D H I F PE + + L Sbjct: 186 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 245 Query: 251 VDPLKRATIKDIREHEWFKQDLP 273 +P +RAT + +H + K P Sbjct: 246 KNPEQRATATQLLQHPFIKNAKP 268 >4J52-A nrPDB Length = 293 Score = 281 bits (719), Expect = 6e-76, Method: Composition-based stats. Identities = 84/258 (32%), Positives = 127/258 (49%), Gaps = 2/258 (0%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G F K T A KI+ + + K+ EI + H H++ + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 F+V+E L + + + E EAR +QI+ Y HR+ V+HRDLK Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 141 Query: 142 PENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC 200 N+ L+ + KI DFGL+ + DGE + CG+PNY APEV+S + + EVD+WS Sbjct: 142 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVWSI 200 Query: 201 GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 G I+Y LL G PF+ + + +I+ + IP+++N A+L+ MLQ DP R TI Sbjct: 201 GCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 260 Query: 261 DIREHEWFKQDLPSYLFP 278 ++ E+F P Sbjct: 261 ELLNDEFFTSGYIPARLP 278 >2A27-A nrPDB Length = 321 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 84/267 (31%), Positives = 132/267 (49%), Gaps = 12/267 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV---VGKIKREIQNLKL 70 Y +G+ LG G F VK + TG + A K + +++ R+ +I+RE+ L+ Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 H ++I L+ V TD +++E VSGGELFD++ + + E EA +QIL V+Y Sbjct: 72 VLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 131 HRHMVVHRDLKPENVLLDAHM----NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + H DLKPEN++L + K+ DFGL++ + DG + G+P + APE+++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL----NRSVA 242 G E D+WS GVI Y LL G PF + I + E + Sbjct: 192 YEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAK 250 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK 269 + +L + KR TI++ H W Sbjct: 251 DFIRKLLVKETRKRLTIQEALRHPWIT 277 >1ZWS-A nrPDB Length = 288 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 84/267 (31%), Positives = 133/267 (49%), Gaps = 12/267 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV---VGKIKREIQNLKL 70 Y +G+ LG G F VK + TG + A K + +++ R+ +I+RE+ L+ Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ 71 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 H ++I L+ V TD +++E VSGGELFD++ + + E EA +QIL V+Y Sbjct: 72 VLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 131 HRHMVVHRDLKPENVLLDAHM----NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 H + H DLKPEN++L + K+ DFGL++ + DG + G+P + APE+++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVA 242 G E D+WS GVI Y LL G PF + I + E + + Sbjct: 192 YEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAK 250 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFK 269 + +L + KR TI++ H W Sbjct: 251 DFIRKLLVKETRKRLTIQEALRHPWIT 277 >4QMW-A nrPDB Length = 310 Score = 277 bits (709), Expect = 7e-75, Method: Composition-based stats. Identities = 76/274 (27%), Positives = 131/274 (47%), Gaps = 8/274 (2%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + + +G G+FG+V G T VA+KI++ ++ + +EI L P+ Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 88 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 + K Y T +++MEY+ GG D + + G ++E + + ++IL +DY H Sbjct: 89 VTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPE 194 +HRD+K NVLL H K+ADFG++ ++D + R T G+P + APEVI Y + Sbjct: 148 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS-K 206 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVDP 253 DIWS G+ L G P + H + I + + ++ + + L +P Sbjct: 207 ADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEP 266 Query: 254 LKRATIKDIREHEWFKQDLP--SYLFPEDPSYDA 285 R T K++ +H++ ++ SYL Y Sbjct: 267 SFRPTAKELLKHKFILRNAKKTSYLTELIDRYKR 300 >6FD3-A nrPDB Length = 300 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 78/269 (28%), Positives = 139/269 (51%), Gaps = 10/269 (3%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y + +G G G V TG +VA+K +N Q+ ++ I EI ++ ++P Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKEL---IINEILVMRENKNP 79 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I+ + ++VMEY++GG L D + + ++E + + ++ L A+D+ H + Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALDFLHSNQ 138 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGP 193 V+HRD+K +N+LL + K+ DFG ++ + R T G+P + APEV++ + Y GP Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 197 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQ 250 +VDIWS G++ ++ G P+ +E+ I PE L+ L L+ Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLE 257 Query: 251 VDPLKRATIKDIREHEWFKQDLP-SYLFP 278 +D +R + K++ +H + K D P S L P Sbjct: 258 MDVDRRGSAKELLQHPFLKLDKPLSSLTP 286 >5YV8-A nrPDB Length = 298 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 147/290 (50%), Gaps = 31/290 (10%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK------------------- 51 V++ Y L D +G G++G VK+ ++ A+K+L+++K Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 52 ----IRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTP--TDFFMVMEYVSGGELFDYI 105 I+ + ++ +EI LK HP+++KL +V+ P +MV E V+ G + + + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-V 128 Query: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165 + E +AR FQ ++ ++Y H ++HRD+KP N+L+ + KIADFG+SN Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 166 DGE-FLRTSCGSPNYAAPEVISG--RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 + L + G+P + APE +S ++++G +D+W+ GV LY + G PF DE + L Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCL 248 Query: 223 FKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 KI+ P+ + + L+ ML +P R + +I+ H W + Sbjct: 249 HSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >2Y8Q-A nrPDB Length = 173 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 91/149 (61%), Positives = 112/149 (75%), Gaps = 2/149 (1%) Query: 402 WHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVD 461 WHLGIRSQS+P DIMAEV RA+KQLD+EWKVVN Y+LRVRRKNPVT + KMSLQLY VD Sbjct: 19 WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVD 78 Query: 462 NRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLT 521 +R+YLLDF+SIDDE+ E +SG++TPQRS S + + S A+ SLT S+T Sbjct: 79 SRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVT 138 Query: 522 G--STLSSVSPRLGSHTMDFFEMCASLIT 548 S+ V+PR GSHT++FFEMCA+LI Sbjct: 139 SLDSSPVDVAPRPGSHTIEFFEMCANLIK 167 >3TAC-A nrPDB Length = 361 Score = 276 bits (706), Expect = 2e-74, Method: Composition-based stats. Identities = 90/278 (32%), Positives = 141/278 (50%), Gaps = 17/278 (6%) Query: 8 DGRVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV--GKIKRE 64 D V Y L + +G G F V+ ++ TG + AVKI++ K S + +KRE Sbjct: 19 DDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKRE 78 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLF 120 + +HPHI++L + S+ +MV E++ G +L I K E A Sbjct: 79 ASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYM 138 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLR-TSCGS 176 +QIL A+ YCH + ++HRD+KP VLL + N K+ FG++ + + + G+ Sbjct: 139 RQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGT 198 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE- 235 P++ APEV+ Y G VD+W CGVIL+ LL G LPF LF+ I G + + Sbjct: 199 PHFMAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTK-ERLFEGIIKGKYKMNPR 256 Query: 236 ---YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 +++ S L+ ML +DP +R T+ + H W K+ Sbjct: 257 QWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >3IS5-A nrPDB Length = 285 Score = 276 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 91/268 (33%), Positives = 136/268 (50%), Gaps = 20/268 (7%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++ LG G FG V + E + +G + +K +N+ RS + +I+ EI+ LK HP+ Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD--RSQVPMEQIEAEIEVLKSLDHPN 81 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYIC----KHGRVEEMEARRLFQQILSAVDYCH 131 IIK+++V + ++VME GGEL + I + + E L +Q+++A+ Y H Sbjct: 82 IIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFH 141 Query: 132 RHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 VVH+DLKPEN+L H KI DFGL+ + E + G+ Y APEV + Sbjct: 142 SQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVF--K 199 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY------LNRSVA 242 + DIWS GV++Y LL G LPF + + +K + P Y L Sbjct: 200 RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQK---ATYKEPNYAVECRPLTPQAV 256 Query: 243 TLLMHMLQVDPLKRATIKDIREHEWFKQ 270 LL ML DP +R + + HEWFKQ Sbjct: 257 DLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >3A8W-A nrPDB Length = 345 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 151/305 (49%), Gaps = 20/305 (6%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL-FRH 73 + L +G G++ KV + + T A+K++ ++ + + + ++ E + H Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P ++ L+ T + F V+EYV+GG+L ++ + ++ E AR +I A++Y H Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 129 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 +++RDLK +NVLLD+ + K+ D+G+ + G+ T CG+PNY APE++ G Y G Sbjct: 130 GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY-G 188 Query: 193 PEVDIWSCGVILYALLCGTLPFD--------DEHVPT-LFKKIRGGVFYIPEYLNRSVAT 243 VD W+ GV+++ ++ G PFD D++ LF+ I IP L+ A+ Sbjct: 189 FSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS 248 Query: 244 LLMHMLQVDPLKRA------TIKDIREHEWFKQDLPSYLFPED--PSYDANVIDDEAVKE 295 +L L DP +R DI+ H +F+ + + P + N+ + + Sbjct: 249 VLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDN 308 Query: 296 VCEKF 300 +F Sbjct: 309 FDSQF 313 >4AF3-A nrPDB Length = 292 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 80/269 (29%), Positives = 136/269 (50%), Gaps = 2/269 (0%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 I + +G LG G FG V + + + VA+K+L + +I V +++REI+ Sbjct: 19 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA 78 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 HP+I++LY ++++EY GEL+ + K +E + +++ A+ Y Sbjct: 79 HLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMY 138 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 CH V+HRD+KPEN+LL KIADFG S + + +T CG+ +Y PE+I GR+ Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGRM 197 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHML 249 + +VD+W GV+ Y LL G PF+ +++I P + L+ +L Sbjct: 198 H-NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 250 QVDPLKRATIKDIREHEWFKQDLPSYLFP 278 + +P +R + + H W + + L P Sbjct: 257 RHNPSERLPLAQVSAHPWVRANSRRVLPP 285 >4JG6-A nrPDB Length = 355 Score = 274 bits (702), Expect = 5e-74, Method: Composition-based stats. Identities = 92/288 (31%), Positives = 139/288 (48%), Gaps = 24/288 (8%) Query: 4 KQKHDGRVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62 +Q H ++ Y + + +GVG++ K H+ T + AVKI+++ K + Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------ 77 Query: 63 REIQNL-KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 EI+ L + +HP+II L V ++V E + GGEL D I + E EA + Sbjct: 78 -EIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLF 136 Query: 122 QILSAVDYCHRHMVVHRDLKPENVL-LDAHMN---AKIADFGLSNMM-SDGEFLRTSCGS 176 I V+Y H VVHRDLKP N+L +D N +I DFG + + ++ L T C + Sbjct: 137 TITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYT 196 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYI 233 N+ APEV+ + Y DIWS GV+LY +L G PF D+ + +I G F + Sbjct: 197 ANFVAPEVLERQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 255 Query: 234 P----EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF--KQDLPSY 275 ++ + L+ ML VDP +R T + H W LP Y Sbjct: 256 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQY 303 >6BDL-A nrPDB Length = 347 Score = 274 bits (702), Expect = 6e-74, Method: Composition-based stats. Identities = 87/305 (28%), Positives = 148/305 (48%), Gaps = 23/305 (7%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTG-HKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 +K+ + + DTLGVG FG+V++ + + A+KIL ++ I I+ E Q ++ Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQ 90 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 I++LY+ +M+ME GGEL+ + G E+ R ++ A Y Sbjct: 91 GAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAY 150 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 H +++RDLKPEN++LD AK+ DFG + + G+ T CG+P Y APE+I + Sbjct: 151 LHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKG 210 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--FYIPEYLNRSVATLLMH 247 + D WS G+++Y LL G+ PF + I G+ P+ + ++ A L+ Sbjct: 211 H-DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKK 269 Query: 248 MLQVDPLKRA-----TIKDIREHEWFKQD--------------LPSYLFPEDPSYDANVI 288 + + +P +R +KDI++H+WF+ +PS P D S + Sbjct: 270 LCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFP 329 Query: 289 DDEAV 293 +D Sbjct: 330 EDNDE 334 >6DTL-A nrPDB Length = 364 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 76/325 (23%), Positives = 134/325 (41%), Gaps = 42/325 (12%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V + T VA+K + +D + REI+ L+ H +I+ + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID-AKRTLREIKLLRHMDHENIVAIRD 96 Query: 82 VISTP-----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVV 136 +I P D ++ E + +L I + + E + QIL + Y H V+ Sbjct: 97 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVL 155 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 HRDLKP N+LL+A+ + KI DFGL+ + S+ +F+ + Y APE++ +D Sbjct: 156 HRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAID 215 Query: 197 IWSCGVILYALLCGTLPFDDEH----VPTLFKKI---------------RGGVFYIPEY- 236 +WS G I L+ F + L + I + + +P Y Sbjct: 216 VWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYP 275 Query: 237 ----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK-----QDLPSYLFPEDP 281 ++ L+ ML DP +R T+ D H + D P P + Sbjct: 276 RQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNF 335 Query: 282 SYDANVIDDEAVKEVCEKFECTESE 306 ++ + + +E +KE+ + + Sbjct: 336 DFENHALSEEQMKELIYREALAFNP 360 >2XIK-A nrPDB Length = 294 Score = 272 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 75/257 (29%), Positives = 124/257 (48%), Gaps = 6/257 (2%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + D +G G+FG+V G T VA+KI++ ++ + +EI L P+ Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 I + + T +++MEY+ GG D + K G +EE + ++IL +DY H Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREILKGLDYLHSERK 137 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPE 194 +HRD+K NVLL + K+ADFG++ ++D + R T G+P + APEVI Y + Sbjct: 138 IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY-DFK 196 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVDP 253 DIWS G+ L G P D H + I + + ++ + L DP Sbjct: 197 ADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDP 256 Query: 254 LKRATIKDIREHEWFKQ 270 R T K++ +H++ + Sbjct: 257 RFRPTAKELLKHKFITR 273 >3DAK-A nrPDB Length = 290 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 130/287 (45%), Gaps = 26/287 (9%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + Y L + +G G V+ KVA+K +N +K ++ + ++ +EIQ Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTS--MDELLKEIQA 61 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--------CKHGRVEEMEARRL 119 + HP+I+ Y + ++VM+ +SGG + D I K G ++E + Sbjct: 62 MSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG------EFLRTS 173 +++L ++Y H++ +HRD+K N+LL + +IADFG+S ++ G + +T Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 174 CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF-- 231 G+P + APEV+ + DIWS G+ L G P+ + Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPS 241 Query: 232 --------YIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + + +S ++ LQ DP KR T ++ H++F++ Sbjct: 242 LETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >4FZF-B nrPDB Length = 283 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 123/258 (47%), Gaps = 6/258 (2%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + + +G G+FG+V G T VA+KI++ ++ + +EI L + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 + K Y + +++MEY+ GG D + + G +E + + ++IL +DY H Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGSALDLL-RAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGPE 194 +HRD+K NVLL + K+A FG++ ++D + R T G+P + APEVI Y + Sbjct: 127 IHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS-K 185 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVDP 253 DIWS G+ L G P D H + I + + +S + L DP Sbjct: 186 ADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDP 245 Query: 254 LKRATIKDIREHEWFKQD 271 R T K++ +H++ ++ Sbjct: 246 SFRPTAKELLKHKFIVKN 263 >4AGU-A nrPDB Length = 311 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 123/290 (42%), Gaps = 33/290 (11%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y +G G++G V ++ TG VA+K + + REI+ LK + Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQLK 60 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HP+++ L +V +V EY L + V E + + Q L AV++CH+ Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK 120 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLYA 191 H +HRD+KPEN+L+ H K+ DFG + +++ ++ + Y +PE++ G Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV-------------------FY 232 GP VD+W+ G + LL G + + IR + Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 233 IPE------------YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 IP+ ++ LL L +DP +R T + + H +F+ Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFEN 290 >2FO0-A nrPDB Length = 495 Score = 269 bits (689), Expect = 2e-72, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 135/298 (45%), Gaps = 26/298 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 ++ + LG G +G+V G + VAVK L + V + +E + Sbjct: 212 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVM 267 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSA 126 K +HP++++L V + F+++ E+++ G L DY+ C V + + QI SA Sbjct: 268 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 327 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y + +HR+L N L+ + K+ADFGLS +M+ G+ G+ + APE Sbjct: 328 MEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPE 386 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYLNRSV 241 ++ + + D+W+ GV+L+ + G P+ + +++ + PE V Sbjct: 387 SLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 445 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEK 299 L+ Q +P R + +I H+ F + + + I DE KE+ ++ Sbjct: 446 YELMRACWQWNPSDRPSFAEI--HQAF-----------ETMFQESSISDEVEKELGKE 490 >1NY3-A nrPDB Length = 400 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 98/318 (30%), Positives = 151/318 (47%), Gaps = 36/318 (11%) Query: 13 IGHYVL-GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KL 70 I Y + LG+G GKV ++ T K A+K+L K +RE++ + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 111 Query: 71 FRHPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQIL 124 + PHI+++ V +VME + GGELF I G E EA + + I Sbjct: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 A+ Y H + HRD+KPEN+L + + K+ DFG + + L T C +P Y A Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE-- 235 PEV+ G D+WS GVI+Y LLCG PF H P + +IR G + P Sbjct: 232 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 Query: 236 --YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 293 ++ V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ Sbjct: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL----- 342 Query: 294 KEVCEKFECTESEVMNSL 311 KE E++E + E+ ++L Sbjct: 343 KEDKERWEDVKEEMTSAL 360 >3NIZ-A nrPDB Length = 311 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 127/295 (43%), Gaps = 37/295 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y + +G GT+G V + G VA+K + + REI LK Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLD-AEDEGIPSTAIREISLLKELH 77 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCH 131 HP+I+ L VI + +V E++ +L + ++ +++ + + Q+L V +CH Sbjct: 78 HPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLY 190 +H ++HRDLKP+N+L+++ K+ADFGL+ + Y AP+V+ G Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 191 AGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFY-------------- 232 VDIWS G I ++ G F DD+ +P +F + Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 233 -------------IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 IP + + LL +ML DP KR + +D H +FK P Sbjct: 257 TFQVFEKKPWSSIIPGFC-QEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQ 310 >4KS7-A nrPDB Length = 292 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 80/281 (28%), Positives = 146/281 (51%), Gaps = 13/281 (4%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D R+ + YV +G G+ G V + + +G +VAVK+++ +R + E+ Sbjct: 20 DPRLLLDSYV---KIGEGSTGIVCLAREKHSGRQVAVKMMD---LRKQQRRELLFNEVVI 73 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++ ++H +++++Y+ + +++ME++ GG L D I R+ E + + + +L A+ Sbjct: 74 MRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQAL 132 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 186 Y H V+HRD+K +++LL K++DFG +S D ++ G+P + APEVIS Sbjct: 133 AYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS 192 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVAT 243 LYA EVDIWS G+++ ++ G P+ + K++R ++ + Sbjct: 193 RSLYAT-EVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRD 251 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFPEDPSY 283 L ML DP +RAT +++ +H + Q LP L P Y Sbjct: 252 FLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLY 292 >2OZA-A nrPDB Length = 356 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 98/318 (30%), Positives = 151/318 (47%), Gaps = 36/318 (11%) Query: 13 IGHYVL-GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KL 70 I Y + LG+G GKV ++ T K A+K+L K +RE++ + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 71 FRHPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQIL 124 + PHI+++ V +VME + GGELF I G E EA + + I Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 A+ Y H + HRD+KPEN+L + + K+ DFG + + L T C +P Y A Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 187 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE-- 235 PEV+ G D+WS GVI+Y LLCG PF H P + +IR G + P Sbjct: 188 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 246 Query: 236 --YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 293 ++ V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ Sbjct: 247 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL----- 298 Query: 294 KEVCEKFECTESEVMNSL 311 KE E++E + E+ ++L Sbjct: 299 KEDKERWEDVKEEMTSAL 316 >3KA0-A nrPDB Length = 320 Score = 268 bits (686), Expect = 4e-72, Method: Composition-based stats. Identities = 97/318 (30%), Positives = 150/318 (47%), Gaps = 36/318 (11%) Query: 13 IGHYVL-GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KL 70 I Y + LG+G GKV ++ T K A+K+L K +RE++ + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 65 Query: 71 FRHPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQIL 124 + PHI+++ V +VME + GGELF I G E EA + + I Sbjct: 66 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 A+ Y H + HRD+KPEN+L + + K+ DFG + + L C +P Y A Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVA 185 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE-- 235 PEV+ G D+WS GVI+Y LLCG PF H P + +IR G + P Sbjct: 186 PEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 244 Query: 236 --YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 293 ++ V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ Sbjct: 245 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL----- 296 Query: 294 KEVCEKFECTESEVMNSL 311 KE E++E + E+ ++L Sbjct: 297 KEDKERWEDVKEEMTSAL 314 >4AW2-A nrPDB Length = 437 Score = 268 bits (686), Expect = 4e-72, Method: Composition-based stats. Identities = 78/310 (25%), Positives = 138/310 (44%), Gaps = 16/310 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+ + + +G G FG+V + + + A+KILN+ ++ + E L Sbjct: 70 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLV 129 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAVD 128 I L+ + ++VM+Y GG+L + K R+ E AR +++ A+D Sbjct: 130 NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAID 189 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGE-FLRTSCGSPNYAAPEVIS 186 H+ VHRD+KP+N+L+D + + ++ADFG +M DG + G+P+Y +PE++ Sbjct: 190 SVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQ 249 Query: 187 ----GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG--GVFYIP---EYL 237 G+ GPE D WS GV +Y +L G PF E + + KI F P + Sbjct: 250 AMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTDV 309 Query: 238 NRSVATLLMHMLQVDPLKRA---TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVK 294 + + L+ ++ R I+D ++H +F + + Y V Sbjct: 310 SENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTS 368 Query: 295 EVCEKFECTE 304 +C + Sbjct: 369 NFDVDDDCLK 378 >6NPU-A nrPDB Length = 298 Score = 268 bits (686), Expect = 4e-72, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 134/297 (45%), Gaps = 26/297 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 ++ + LG G +G+V G + VAVK L + V + +E + Sbjct: 21 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVM 76 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSA 126 K +HP++++L V + F+++ E+++ G L DY+ C V + + QI SA Sbjct: 77 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 136 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y + +HRDL N L+ + K+ADFGLS +M+ G+ G+ + APE Sbjct: 137 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPE 195 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYLNRSV 241 ++ + + D+W+ GV+L+ + G P+ + +++ + PE V Sbjct: 196 SLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 254 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 L+ Q +P R + +I H+ F + + + I DE KE+ + Sbjct: 255 YELMRACWQWNPSDRPSFAEI--HQAF-----------ETMFQESSISDEVEKELGK 298 >4XEY-B nrPDB Length = 408 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 135/298 (45%), Gaps = 26/298 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 ++ + LG G +G+V G + VAVK L + V + +E + Sbjct: 120 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVM 175 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSA 126 K +HP++++L V + F+++ E+++ G L DY+ C V + + QI SA Sbjct: 176 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 235 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y + +HRDL N L+ + K+ADFGLS +M+ G+ G+ + APE Sbjct: 236 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPE 294 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYLNRSV 241 ++ + + D+W+ GV+L+ + G P+ + +++ + PE V Sbjct: 295 SLAYNKF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 353 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEK 299 L+ Q +P R + +I H+ F + + + I DE KE+ ++ Sbjct: 354 YELMRACWQWNPSDRPSFAEI--HQAF-----------ETMFQESSISDEVEKELGKQ 398 >2XYN-A nrPDB Length = 292 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 119/260 (45%), Gaps = 13/260 (5%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 ++ + LG G +G+V +G + VAVK L + V + +E + Sbjct: 27 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVM 82 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSA 126 K +HP++++L V + F++V EY+ G L DY+ C V + + QI SA Sbjct: 83 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 142 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y + +HRDL N L+ + K+ADFGLS +M+ G+ G+ + APE Sbjct: 143 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPE 201 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSV 241 ++ + + D+W+ GV+L+ + G P+ + ++ + G PE V Sbjct: 202 SLAYNTF-SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 260 Query: 242 ATLLMHMLQVDPLKRATIKD 261 L+ + P R + + Sbjct: 261 YELMRACWKWSPADRPSFAE 280 >1CM8-A nrPDB Length = 367 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 86/331 (25%), Positives = 134/331 (40%), Gaps = 44/331 (13%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y +G G +G V TG KVA+K L R +S + RE++ LK RH + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRHEN 85 Query: 76 IIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 +I L V + TDF++VM ++ G +L + KH ++ E + L Q+L + Y Sbjct: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LMKHEKLGEDRIQFLVYQMLKGLRY 143 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI + Sbjct: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWM 201 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL------------ 237 VDIWS G I+ ++ G F K+I P Sbjct: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 Query: 238 -------------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFP 278 + LL ML +D +R T + H +F+ + P Sbjct: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEP 321 Query: 279 EDPSYDANVIDDEAVKEVCEKFECTESEVMN 309 + YD + D + + + E T EV++ Sbjct: 322 QVQKYDDSFDDVD--RTLDEWKRVTYKEVLS 350 >3TKU-A nrPDB Length = 433 Score = 267 bits (684), Expect = 6e-72, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 142/319 (44%), Gaps = 21/319 (6%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + E Q H + + +G G FG+V + + + T A+KILN+ ++ Sbjct: 82 VKEMQLH-----REDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 136 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRL 119 + E L I L+ ++VM+Y GG+L + K ++ E AR Sbjct: 137 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 196 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSP 177 +++ A+D H+ VHRD+KP+NVLLD + + ++ADFG M+D +++S G+P Sbjct: 197 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 256 Query: 178 NYAAPEVIS----GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG--GVF 231 +Y +PE++ G GPE D WS GV +Y +L G PF E + + KI F Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF 316 Query: 232 YIPEY---LNRSVATLLMHMLQVDPLKRA---TIKDIREHEWFKQDLPSYLFPEDPSYDA 285 P + ++ L+ ++ +R I+D ++H +F+ + + Y Sbjct: 317 QFPSHVTDVSEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIP 375 Query: 286 NVIDDEAVKEVCEKFECTE 304 +V + Sbjct: 376 DVSSPSDTSNFDVDDDVLR 394 >2H8H-A nrPDB Length = 535 Score = 267 bits (684), Expect = 6e-72, Method: Composition-based stats. Identities = 75/286 (26%), Positives = 126/286 (44%), Gaps = 19/286 (6%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 K + L LG G FG+V +G T +VA+K L + +E Sbjct: 259 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEA 313 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQI 123 Q +K RH +++LY V+S ++V EY+S G L D++ + + + QI Sbjct: 314 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 372 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAA 181 S + Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + A Sbjct: 373 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 432 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 239 PE + + D+WS G++L L G +P+ + ++ RG P Sbjct: 433 PEAALYGRFT-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 491 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285 S+ L+ + +P +R T + + + L Y +P Y Sbjct: 492 SLHDLMCQCWRKEPEERPTFE------YLQAFLEDYFTSTEPQYQP 531 >3UTO-A nrPDB Length = 573 Score = 267 bits (684), Expect = 7e-72, Method: Composition-based stats. Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 17/279 (6%) Query: 4 KQKHDGRVKI------GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV 57 KQ + V+I HY + + LG G FG V + TG+ A K + + Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 200 Query: 58 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEA 116 V ++EIQ + + RHP ++ L+ + M+ E++SGGELF+ + +H ++ E EA Sbjct: 201 V---RKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 257 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSC 174 +Q+ + + H + VH DLKPEN++ K+ DFGL+ + + ++ + Sbjct: 258 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 317 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP 234 G+ +AAPEV G+ G D+WS GV+ Y LL G PF E+ + ++ + + Sbjct: 318 GTAEFAAPEVAEGKP-VGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMD 376 Query: 235 EY----LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + ++ + +L DP R TI EH W Sbjct: 377 DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 415 >3OHT-A nrPDB Length = 389 Score = 267 bits (683), Expect = 7e-72, Method: Composition-based stats. Identities = 86/344 (25%), Positives = 134/344 (38%), Gaps = 44/344 (12%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y +G G +G V +G K+AVK L+R +S+ + RE++ LK +H Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRP-FQSIIHAKRTYRELRLLKHMKH 109 Query: 74 PHIIKLYQVI------STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++I L V D ++V + G +L + I K ++ + + L QIL + Sbjct: 110 ENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGL 167 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 168 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLN 225 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---------- 237 ++ VDIWS G I+ LL G F ++I P + Sbjct: 226 WMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEAR 285 Query: 238 ---------------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276 N LL ML +D KR T + H +F Q Sbjct: 286 NYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDPDD 345 Query: 277 FPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQL 320 PE YD + + E+ E T EV + D++ Sbjct: 346 EPESEPYDQSF--ESRQLEIEEWKRLTYEEVCSFETPPFDGDEM 387 >2F57-A nrPDB Length = 317 Score = 267 bits (683), Expect = 9e-72, Method: Composition-based stats. Identities = 82/284 (28%), Positives = 145/284 (51%), Gaps = 13/284 (4%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D R + +++ +G G+ G V I + TG +VAVK ++ +R + E+ Sbjct: 42 DPREYLANFI---KIGEGSTGIVCIATEKHTGKQVAVKKMD---LRKQQRRELLFNEVVI 95 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++ + H +++ +Y + ++VME++ GG L D I H R+ E + + +L A+ Sbjct: 96 MRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIATVCLSVLRAL 154 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVIS 186 Y H V+HRD+K +++LL + K++DFG +S R + G+P + APEVIS Sbjct: 155 SYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS 214 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---NRSVAT 243 RL G EVDIWS G+++ ++ G P+ +E ++IR + + L + + Sbjct: 215 -RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRG 273 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFK-QDLPSYLFPEDPSYDAN 286 L ML +P +RAT +++ H + K PS + P Y + Sbjct: 274 FLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 317 >3Q53-A nrPDB Length = 306 Score = 267 bits (683), Expect = 1e-71, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 139/269 (51%), Gaps = 10/269 (3%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y + +G G G V TG +VA++ +N Q+ ++ I EI ++ ++P Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKEL---IINEILVMRENKNP 78 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134 +I+ + ++VMEY++GG L D + + ++E + + ++ L A+++ H + Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-MDEGQIAAVCRECLQALEFLHSNQ 137 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEVISGRLYAGP 193 V+HRD+K +N+LL + K+ DFG ++ + R T G+P + APEV++ + Y GP Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 196 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG---VFYIPEYLNRSVATLLMHMLQ 250 +VDIWS G++ ++ G P+ +E+ I PE L+ L L+ Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLE 256 Query: 251 VDPLKRATIKDIREHEWFKQDLP-SYLFP 278 +D KR + K++ +H++ K P S L P Sbjct: 257 MDVEKRGSAKELIQHQFLKIAKPLSSLTP 285 >5DBX-A nrPDB Length = 328 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 132/290 (45%), Gaps = 26/290 (8%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 Q + Y L + +G G V+ + +VA+K +N +K ++ + ++ +E Sbjct: 2 QAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTS--MDELLKE 59 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI--------CKHGRVEEMEA 116 IQ + HP+++ Y + ++VM+ +SGG + D I K+G +EE Sbjct: 60 IQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAII 119 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG------EFL 170 + +++L +DY HR+ +HRDLK N+LL + +IADFG+S ++ G + Sbjct: 120 ATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVR 179 Query: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV 230 + G+P + APEV+ + D+WS G+ L G P+ + Sbjct: 180 KDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND 239 Query: 231 F----------YIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + + +S LL LQ DP KR T ++ + ++F++ Sbjct: 240 PPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >4BBM-A nrPDB Length = 331 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 123/291 (42%), Gaps = 33/291 (11%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y +G G++G V ++ TG VA+K + V REI+ LK R Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF-LESDDDKMVKKIAMREIKLLKQLR 82 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H +++ L +V +++V E+V L D ++ ++ QI++ + +CH Sbjct: 83 HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS 142 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLYA 191 H ++HRD+KPEN+L+ K+ DFG + + + GE + Y APE++ G + Sbjct: 143 HNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKY 202 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV-------------------FY 232 G VD+W+ G ++ + G F + I + Sbjct: 203 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 262 Query: 233 IPEY------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 +PE L+ V L L +DP KR ++ H++F+ D Sbjct: 263 LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMD 313 >6F3F-A nrPDB Length = 455 Score = 266 bits (679), Expect = 3e-71, Method: Composition-based stats. Identities = 74/286 (25%), Positives = 126/286 (44%), Gaps = 19/286 (6%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 K + L LG G FG+V +G T +VA+K L + +E Sbjct: 179 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEA 233 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQI 123 Q +K RH +++LY V+S ++V EY++ G L D++ + + + QI Sbjct: 234 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQI 292 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAA 181 S + Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + A Sbjct: 293 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 352 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 239 PE + + D+WS G++L L G +P+ + ++ RG P Sbjct: 353 PEAALYGRFT-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 411 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285 S+ L+ + +P +R T + + + L Y +P Y Sbjct: 412 SLHDLMCQCWRKEPEERPTFE------YLQAFLEDYFTSTEPQYQP 451 >4C0T-A nrPDB Length = 974 Score = 266 bits (679), Expect = 3e-71, Method: Composition-based stats. Identities = 84/304 (27%), Positives = 144/304 (47%), Gaps = 16/304 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R + + G LG G++ V + ++TG + AVK+L+++ I V + E L Sbjct: 262 RRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN 321 Query: 70 LFRHP-HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 + +I LY + V++Y S GEL I ++ + E R QIL A+ Sbjct: 322 RLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD----------GEFLRTSCGSPN 178 Y H + V+HRDLKPEN+LLD M +I DFG + ++ ++ G+ Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 Y +PE++ + Y G D+W+ G I+Y ++ G PF + F+KI F Sbjct: 442 YVSPELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFP 500 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK----QDLPSYLFPEDPSYDANVIDDEAVK 294 + L+ +L + P +RATI +I++H +F+ +D S + P + +++ Sbjct: 501 TIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMM 560 Query: 295 EVCE 298 +V E Sbjct: 561 KVPE 564 >2X4F-A nrPDB Length = 373 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 77/258 (29%), Positives = 127/258 (49%), Gaps = 11/258 (4%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + LG G FG+V E TG K+A KI+ + ++ + ++K EI + H ++I+L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKE---EVKNEISVMNQLDHANLIQL 151 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHMVVHR 138 Y + D +VMEYV GGELFD I + E++ +QI + + H+ ++H Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHL 211 Query: 139 DLKPENVL-LDAH-MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD 196 DLKPEN+L ++ KI DFGL+ E L+ + G+P + APEV++ + P D Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFP-TD 270 Query: 197 IWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVATLLMHMLQVD 252 +WS GVI Y LL G PF ++ I + + + ++ + +L + Sbjct: 271 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 330 Query: 253 PLKRATIKDIREHEWFKQ 270 R + + +H W Sbjct: 331 KSWRISASEALKHPWLSD 348 >2HW6-A nrPDB Length = 307 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 81/302 (26%), Positives = 136/302 (45%), Gaps = 38/302 (12%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 G+ + + + + LG G + KV+ G + AVKI+ +Q S ++ RE++ Sbjct: 7 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHS---RSRVFREVET 63 Query: 68 LKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 L + + +I++L + T F++V E + GG + +I K E EA R+ + + +A Sbjct: 64 LYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAA 123 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMS--------DGEFLRTSCG 175 +D+ H + HRDLKPEN+L ++ KI DF L + M L T CG Sbjct: 124 LDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCG 183 Query: 176 SPNYAAPEVIS----GRLYAGPEVDIWSCGVILYALLCGTLPFDDE-------------- 217 S Y APEV+ + D+WS GV+LY +L G PF Sbjct: 184 SAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCR 243 Query: 218 -HVPTLFKKIRGGVFYIPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDL 272 LF+ I+ G + P+ +++ L+ +L D +R + + +H W + Sbjct: 244 VCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQA 303 Query: 273 PS 274 P Sbjct: 304 PE 305 >3PPZ-A nrPDB Length = 309 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 76/280 (27%), Positives = 130/280 (46%), Gaps = 14/280 (5%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 D + + + +G G+FG V E G VAVKIL Q + + V + RE Sbjct: 28 DGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHA-ERVNEFLRE 84 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG---RVEEMEARRLFQ 121 + +K RHP+I+ ++ P + +V EY+S G L+ + K G +++E + Sbjct: 85 VAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAY 144 Query: 122 QILSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPN 178 + ++Y H +VHRDLK N+L+D K+ DFGLS + + +++ G+P Sbjct: 145 DVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPE 204 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFYIPEY 236 + APEV+ + + D++S GVIL+ L P+ + + + + + IP Sbjct: 205 WMAPEVLRDEP-SNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRN 263 Query: 237 LNRSVATLLMHMLQVDPLKRATIKDI--REHEWFKQDLPS 274 LN VA ++ +P KR + I K +P Sbjct: 264 LNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPP 303 >4JDH-A nrPDB Length = 346 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 78/279 (27%), Positives = 144/279 (51%), Gaps = 13/279 (4%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 D R + +++ +G G+ G V I + +G VAVK ++ +R + E Sbjct: 68 DPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNE 121 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 + ++ ++H +++++Y + ++VME++ GG L D I H R+ E + + +L Sbjct: 122 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVL 180 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPE 183 A+ H V+HRD+K +++LL K++DFG +S + ++ G+P + APE Sbjct: 181 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 240 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---NRS 240 +IS RL GPEVDIWS G+++ ++ G P+ +E K IR + + L + S Sbjct: 241 LIS-RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPS 299 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFP 278 + L +L DP +RAT ++ +H + + P+ + P Sbjct: 300 LKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 338 >2Q0N-A nrPDB Length = 301 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 78/279 (27%), Positives = 144/279 (51%), Gaps = 13/279 (4%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 D R + +++ +G G+ G V I + +G VAVK ++ +R + E Sbjct: 23 DPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNE 76 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 + ++ ++H +++++Y + ++VME++ GG L D I H R+ E + + +L Sbjct: 77 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVL 135 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPE 183 A+ H V+HRD+K +++LL K++DFG +S + ++ G+P + APE Sbjct: 136 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 195 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---NRS 240 +IS RL GPEVDIWS G+++ ++ G P+ +E K IR + + L + S Sbjct: 196 LIS-RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPS 254 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFP 278 + L +L DP +RAT ++ +H + + P+ + P Sbjct: 255 LKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 293 >5AWM-A nrPDB Length = 394 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 89/365 (24%), Positives = 136/365 (37%), Gaps = 64/365 (17%) Query: 2 AEKQKHDGRVKIGHYVL------GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL 55 A+ Q + V ++ + +G G G V +T VA+K L+R +++ Sbjct: 26 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNV 84 Query: 56 DVVGKIKREIQNLKLFRHPHIIKLYQVI------STPTDFFMVMEYVSGGELFDYICKHG 109 + RE + +KL H +II L D ++VME + L I Sbjct: 85 THAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVI--QM 141 Query: 110 RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 169 ++ L Q+L + + H ++HRDLKP N+++ A KI DFGL+ Sbjct: 142 DLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 170 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--- 226 + + Y APEVI G Y VDIWS G I+ ++ G + F + KI Sbjct: 202 MTPYVVTRYYRAPEVILGMGYT-ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQ 260 Query: 227 ----------------RGGVFYIPEYL------------------------NRSVATLLM 246 R V P Y LL Sbjct: 261 LGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLS 320 Query: 247 HMLQVDPLKRATIKDIREHEWFK--QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTE 304 ML +DP +R ++ + +HE+ D P YD +V DE V + E Sbjct: 321 KMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSV--DEREHTVEQWKELIY 378 Query: 305 SEVMN 309 EVM+ Sbjct: 379 EEVMD 383 >4EWQ-A nrPDB Length = 383 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 88/344 (25%), Positives = 138/344 (40%), Gaps = 44/344 (12%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y +G G +G V TG +VAVK L+R +S+ + RE++ LK +H Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKH 103 Query: 74 PHIIKLYQVI------STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++I L V D ++V + G +L + I K ++ + + L QIL + Sbjct: 104 ENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGL 161 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Y H ++HRDLKP N+ ++ KI DFGL+ D + + Y APE++ Sbjct: 162 KYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLN 219 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHV---------------PTLFKKIRGG--- 229 ++ VDIWS G I+ LL G F L KKI Sbjct: 220 WMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESAR 279 Query: 230 -----VFYIPEY--------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276 + +P+ N LL ML +D KR T H +F Q Sbjct: 280 NYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDD 339 Query: 277 FPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQL 320 P YD + + + + E T EV++ + Q+++ Sbjct: 340 EPVADPYDQSFESRDLL--IDEWKSLTYDEVISFVPPPLDQEEM 381 >1KOA-A nrPDB Length = 491 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 80/279 (28%), Positives = 134/279 (48%), Gaps = 17/279 (6%) Query: 4 KQKHDGRVKI------GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV 57 KQ + V+I HY + + LG G FG V + TG+ A K + + Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKET 94 Query: 58 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEA 116 V ++EIQ + + RHP ++ L+ + M+ E++SGGELF+ + +H ++ E EA Sbjct: 95 V---RKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEA 151 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSC 174 +Q+ + + H + VH DLKPEN++ K+ DFGL+ + + ++ + Sbjct: 152 VEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT 211 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP 234 G+ +AAPEV G+ G D+WS GV+ Y LL G PF E+ + ++ + + Sbjct: 212 GTAEFAAPEVAEGKP-VGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMD 270 Query: 235 EY----LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + ++ + +L DP R TI EH W Sbjct: 271 DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 309 >4FR4-A nrPDB Length = 384 Score = 265 bits (677), Expect = 5e-71, Method: Composition-based stats. Identities = 75/269 (27%), Positives = 134/269 (49%), Gaps = 6/269 (2%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + V H+ + +G G+FGKV I + T A+K +N+QK + V + +E+Q Sbjct: 9 NEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQI 68 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 ++ HP ++ L+ D FMV++ + GG+L ++ ++ +E + +++ A+ Sbjct: 69 MQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMAL 128 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 DY ++HRD+KP+N+LLD H + I DF ++ M+ + T G+ Y APE+ S Sbjct: 129 DYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSS 188 Query: 188 RLYAGPE--VDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIPEYLNRSVA 242 R AG VD WS GV Y LL G P+ + V P ++ + Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMV 248 Query: 243 TLLMHMLQVDPLKRAT-IKDIREHEWFKQ 270 +LL +L+ +P +R + + D++ + Sbjct: 249 SLLKKLLEPNPDQRFSQLSDVQNFPYMND 277 >5SYS-A nrPDB Length = 286 Score = 264 bits (676), Expect = 5e-71, Method: Composition-based stats. Identities = 75/286 (26%), Positives = 125/286 (43%), Gaps = 19/286 (6%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 K + L LG G FG+ +G T +VA+K L + +E Sbjct: 10 KDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEA 64 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQI 123 Q +K RH +++LY V+S ++V EY+S G L D++ + + + QI Sbjct: 65 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI 123 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAA 181 S + Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + A Sbjct: 124 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 183 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 239 PE + + D+WS G++L L G +P+ + ++ RG P Sbjct: 184 PEAALYGRFT-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 242 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285 S+ L+ + DP +R T + + + L Y +P Y Sbjct: 243 SLHDLMCQCWRKDPEERPTFE------YLQAFLEDYFTSTEPQYQP 282 >2DQ7-X nrPDB Length = 283 Score = 264 bits (676), Expect = 5e-71, Method: Composition-based stats. Identities = 73/286 (25%), Positives = 130/286 (45%), Gaps = 19/286 (6%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 K + L LG G FG+V +G KVA+K L + E Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSP----ESFLEEA 55 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQI 123 Q +K +H +++LY V+S ++V EY++ G L D++ + ++ + Q+ Sbjct: 56 QIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQV 114 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAA 181 + + Y R +HRDL+ N+L+ + KIADFGL+ ++ D E+ R P + A Sbjct: 115 AAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTA 174 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 239 PE + + D+WS G++L L+ G +P+ + + +++ RG P+ Sbjct: 175 PEAALYGRFT-IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPI 233 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285 S+ L++H + DP +R T + + + L Y +P Y Sbjct: 234 SLHELMIHCWKKDPEERPTFE------YLQSFLEDYFTATEPQYQP 273 >4XBR-A nrPDB Length = 366 Score = 264 bits (676), Expect = 5e-71, Method: Composition-based stats. Identities = 78/279 (27%), Positives = 144/279 (51%), Gaps = 13/279 (4%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 D R + +++ +G G+ G V I + +G VAVK ++ +R + E Sbjct: 88 DPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNE 141 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 + ++ ++H +++++Y + ++VME++ GG L D I H R+ E + + +L Sbjct: 142 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVL 200 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPE 183 A+ H V+HRD+K +++LL K++DFG +S + ++ G+P + APE Sbjct: 201 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 260 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---NRS 240 +IS RL GPEVDIWS G+++ ++ G P+ +E K IR + + L + S Sbjct: 261 LIS-RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPS 319 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFP 278 + L +L DP +RAT ++ +H + + P+ + P Sbjct: 320 LKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 358 >1KOB-A nrPDB Length = 387 Score = 264 bits (675), Expect = 7e-71, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 136/293 (46%), Gaps = 12/293 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y + + LG G FG V + TG K +N +K EI + H Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDK---YTVKNEISIMNQLHH 107 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHR 132 P +I L+ + +++E++SGGELFD I ++ E E +Q + + H Sbjct: 108 PKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE 167 Query: 133 HMVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 H +VH D+KPEN++ + + KI DFGL+ ++ E ++ + + +AAPE++ R Sbjct: 168 HSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-DREP 226 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY----LNRSVATLLM 246 G D+W+ GV+ Y LL G PF E + ++ + E ++ + Sbjct: 227 VGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIK 286 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEK 299 ++LQ +P KR T+ D EH W K D S L PS N I + ++ + Sbjct: 287 NLLQKEPRKRLTVHDALEHPWLKGDH-SNLTSRIPSSRYNKIRQKIKEKYADW 338 >4APC-A nrPDB Length = 350 Score = 264 bits (675), Expect = 8e-71, Method: Composition-based stats. Identities = 68/273 (24%), Positives = 131/273 (47%), Gaps = 10/273 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + YV +G G+FGK + + G + +K +N ++ S + + +RE+ L + Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKE-REESRREVAVLANMK 81 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVDYC 130 HP+I++ + ++VM+Y GG+LF I +E + F QI A+ + Sbjct: 82 HPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHV 141 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSPNYAAPEVISGRL 189 H ++HRD+K +N+ L ++ DFG++ +++ E R G+P Y +PE+ + Sbjct: 142 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKP 201 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE---YLNRSVATLLM 246 Y + DIW+ G +LY L F+ + L KI G P + + + +L+ Sbjct: 202 YNN-KSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG--SFPPVSLHYSYDLRSLVS 258 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 279 + + +P R ++ I E + + + +L P+ Sbjct: 259 QLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQ 291 >5J5T-A nrPDB Length = 370 Score = 264 bits (675), Expect = 8e-71, Method: Composition-based stats. Identities = 77/357 (21%), Positives = 136/357 (38%), Gaps = 34/357 (9%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + L +G GT+G V + TG A+K++ + VV + EI +K +H Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKH 60 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P+I+ + ++ ME+ GG L D G + E++ + ++ L + Y H Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEV--ISGRLY 190 +HRD+K N+LL + + K+ADFG+S ++ R G+P + APEV + + Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-----LNRSVATLL 245 D+W+ G+ L P D H + F P+ + S + Sbjct: 181 YNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFV 240 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTES 305 L +P KR T + + +H + Q L + E + +V T Sbjct: 241 KMALTKNPKKRPTAEKLLQHPFVTQHL------------TRSLAIELLDKVNNPDHSTYH 288 Query: 306 EVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFY------LASSPPSGSFMDDSA 356 + + D + L H I R + + + PP + Sbjct: 289 D-----FDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHH 340 >4FIE-A nrPDB Length = 423 Score = 264 bits (674), Expect = 8e-71, Method: Composition-based stats. Identities = 78/279 (27%), Positives = 144/279 (51%), Gaps = 13/279 (4%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 D R + +++ +G G+ G V I + +G VAVK ++ +R + E Sbjct: 145 DPGDPRSYLDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNE 198 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQIL 124 + ++ ++H +++++Y + ++VME++ GG L D I H R+ E + + +L Sbjct: 199 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVL 257 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPE 183 A+ H V+HRD+K +++LL K++DFG +S + ++ G+P + APE Sbjct: 258 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 317 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL---NRS 240 +IS RL GPEVDIWS G+++ ++ G P+ +E K IR + + L + S Sbjct: 318 LIS-RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPS 376 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQD-LPSYLFP 278 + L +L DP +RAT ++ +H + + P+ + P Sbjct: 377 LKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 415 >3V5Q-A nrPDB Length = 297 Score = 264 bits (674), Expect = 9e-71, Method: Composition-based stats. Identities = 79/282 (28%), Positives = 117/282 (41%), Gaps = 30/282 (10%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEH-----QLTGHKVAVKILNRQKIRSLDVVGKI 61 H +K VL LG G FGKV + E VAVK L K +L Sbjct: 8 HVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKAL---KDPTLAARKDF 64 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----------- 110 +RE + L +H HI+K Y V MV EY+ G+L ++ HG Sbjct: 65 QREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPR 124 Query: 111 -----VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165 + + + QI S + Y VHRDL N L+ A++ KI DFG+S + Sbjct: 125 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 184 Query: 166 DGEFLRTSCGS---PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPT 221 ++ R + + PE I R + E D+WS GVIL+ + G P+ Sbjct: 185 STDYYRVGGHTMLPIRWMPPESIMYRKFTT-ESDVWSFGVILWEIFTYGKQPWFQLSNTE 243 Query: 222 LFKKIRGGV-FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 + + I G P + V +++ Q +P +R IK+I Sbjct: 244 VIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 285 >6GU6-A nrPDB Length = 302 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 78/291 (26%), Positives = 120/291 (41%), Gaps = 35/291 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y + +G GT+G V G H+ TG VA+K + + V REI LK R Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELR 64 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK---HGRVEEMEARRLFQQILSAVDY 129 HP+I+ L V+ + +++ E++S +L Y+ ++ + QIL + + Sbjct: 65 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 123 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGR 188 CH V+HRDLKP+N+L+D K+ADFGL+ + Y +PEV+ G Sbjct: 124 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 183 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI------------------RGGV 230 VDIWS G I L F + +I + Sbjct: 184 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 243 Query: 231 FYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 P++ L+ + LL ML DP KR + K H +F Sbjct: 244 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 294 >3KN6-A nrPDB Length = 325 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 94/275 (34%), Positives = 147/275 (53%), Gaps = 26/275 (9%) Query: 15 HYVLG---DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 HY L LG G+F + H+ + AVKI++++ + ++EI LKL Sbjct: 9 HYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR------MEANTQKEITALKLC 62 Query: 72 R-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 HP+I+KL++V F+VME ++GGELF+ I K E EA + ++++SAV + Sbjct: 63 EGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHM 122 Query: 131 HRHMVVHRDLKPENVLL---DAHMNAKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVIS 186 H VVHRDLKPEN+L + ++ KI DFG + + D + L+T C + +YAAPE+++ Sbjct: 123 HDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLN 182 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP-------TLFKKIRGGVFYIP----E 235 Y D+WS GVILY +L G +PF + KKI+ G F + Sbjct: 183 QNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWK 241 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 +++ L+ +L VDP KR + +R +EW + Sbjct: 242 NVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >3FXW-A nrPDB Length = 336 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 95/317 (29%), Positives = 148/317 (46%), Gaps = 37/317 (11%) Query: 14 GHYVLGD-TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 Y L LG+G GKV H+ TG K A+K+L K ++E+ + Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP--------KARQEVDHHWQAS 79 Query: 73 -HPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILS 125 PHI+ + V ++ME + GGELF I + G E EA + + I + Sbjct: 80 GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGT 139 Query: 126 AVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 A+ + H H + HRD+KPEN+L + K+ DFG + + L+T C +P Y AP Sbjct: 140 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQN-ALQTPCYTPYYVAP 198 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE--- 235 EV+ G D+WS GVI+Y LLCG PF P + ++IR G + P Sbjct: 199 EVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEW 257 Query: 236 -YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVK 294 ++ L+ +L+ DP +R TI H W Q S + P+ P + A V+ + Sbjct: 258 SEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ---SMVVPQTPLHTARVL-----Q 309 Query: 295 EVCEKFECTESEVMNSL 311 E + ++ + E+ ++L Sbjct: 310 EDKDHWDEVKEEMTSAL 326 >4WNO-A nrPDB Length = 287 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 86/280 (30%), Positives = 130/280 (46%), Gaps = 18/280 (6%) Query: 4 KQKHDGRVKIGHYVLGDT--LGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVGK 60 + G +G + +G G F V G H+ +VAVK +N++ + + Sbjct: 6 EPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTL-- 63 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + +EI+ LK +H +I+ LY ++VMEY +GG+L DY+ + E R Sbjct: 64 LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFL 123 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHM---------NAKIADFGLSNMMSDGEFLR 171 QQI A+ H ++HRDLKP+N+LL KIADFG + + Sbjct: 124 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAA 183 Query: 172 TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL---FKKIRG 228 T CGSP Y APEVI + Y G + D+WS G I+Y L G PF L ++K + Sbjct: 184 TLCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT 242 Query: 229 GVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 V IP + + LL+ +LQ + R + H + Sbjct: 243 LVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >5VO2-A nrPDB Length = 300 Score = 261 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 79/300 (26%), Positives = 124/300 (41%), Gaps = 19/300 (6%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 V + +G G G V +G G +VAVK + K I++L Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD----------IKHL 54 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 + +HP+II V + + ++ME+ + G+L++ + V I ++ Sbjct: 55 RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 114 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Y H H ++HRDLK N+L+ KI+DFG S +SD + G+ + APEVI Sbjct: 115 YLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNE 174 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEYLNRSVATLLM 246 +VDIWS GV+L+ LL G +P+ D + + ++ P LL Sbjct: 175 P-VSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLR 233 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESE 306 P R + + I H D+ S P E +EV FE +SE Sbjct: 234 QCWNSKPRNRPSFRQILLH----LDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSE 289 >6QAU-A nrPDB Length = 280 Score = 261 bits (666), Expect = 7e-70, Method: Composition-based stats. Identities = 86/273 (31%), Positives = 136/273 (49%), Gaps = 18/273 (6%) Query: 13 IGHYVLGD--TLGVGTFGKVKIGEHQL-TGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 +G + +G G F V G H+ T +VA+K +N++ + ++ + +EI+ LK Sbjct: 8 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL--LGKEIKILK 65 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 +H +I+ LY V P F+VMEY +GG+L DY+ G + E R QI +A+ Sbjct: 66 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRI 125 Query: 130 CHRHMVVHRDLKPENVLLD---------AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 H ++HRDLKP+N+LL + + KIADFG + + CGSP Y Sbjct: 126 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYM 185 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL---FKKIRGGVFYIPEYL 237 APEVI + + + D+WS G ++Y L G PF L ++K R + IP Sbjct: 186 APEVIMSQ-HYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET 244 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + +A LL+ +LQ + R + H + +Q Sbjct: 245 SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 277 >4EBW-A nrPDB Length = 304 Score = 260 bits (665), Expect = 9e-70, Method: Composition-based stats. Identities = 71/265 (26%), Positives = 118/265 (44%), Gaps = 12/265 (4%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKR 63 D ++ LG +G G FG V G + + VA+K S V K + Sbjct: 31 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK--NCTSDSVREKFLQ 88 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQ 122 E ++ F HPHI+KL VI T +++ME + GEL ++ + ++ Q Sbjct: 89 EALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ 147 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG--SPNYA 180 + +A+ Y VHRD+ NVL+ ++ K+ DFGLS M D + + S G + Sbjct: 148 LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 207 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLN 238 APE I+ R + D+W GV ++ +L G PF + +I G +P Sbjct: 208 APESINFRRFTSA-SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP 266 Query: 239 RSVATLLMHMLQVDPLKRATIKDIR 263 ++ +L+ DP +R +++ Sbjct: 267 PTLYSLMTKCWAYDPSRRPRFTELK 291 >3ZDU-A nrPDB Length = 325 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 141/322 (43%), Gaps = 36/322 (11%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y +G G++G V +H+ TG VA+KI + +S++ + REI+ LK F H + Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKI--AMREIKFLKQFHHEN 62 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 ++ L +V +V E++ L + +E R+ QIL A+DY H + + Sbjct: 63 LVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 +HRD+KPEN+L+ K+ DFG + + + G+ + Y APE++ G Sbjct: 123 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKP 182 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYL----NRS---------- 240 VDIW+ G ++ + G L KI V + +L ++S Sbjct: 183 VDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQ 242 Query: 241 -----------------VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 283 +A ++ LQ+DP R + D+ HE+F +D ++ P Sbjct: 243 VQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD--GFIEKFMPEL 300 Query: 284 DANVIDDEAVKEVCEKFECTES 305 A ++ + V + + E ++ Sbjct: 301 KAKLLQEAKVNSLIKPKESSKE 322 >4AU8-A nrPDB Length = 296 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 125/298 (41%), Gaps = 34/298 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G + Y + +G GT+G V +++ T VA+K + V REI L Sbjct: 1 GAMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLL 59 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAV 127 K +H +I++L+ V+ + +V E+ +L Y +G ++ + Q+L + Sbjct: 60 KELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 186 +CH V+HRDLKP+N+L++ + K+ADFGL+ + Y P+V+ Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF 178 Query: 187 GRLYAGPEVDIWSCGVILYALL-CGTLPFDDEHVPTLFKKIRG-----------GVFYIP 234 G +D+WS G I L G F V K+I + +P Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 238 Query: 235 EYLNRSVA------------------TLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 +Y + LL ++L+ +P++R + ++ +H +F P Sbjct: 239 DYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >5H2U-A nrPDB Length = 267 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 68/260 (26%), Positives = 120/260 (46%), Gaps = 10/260 (3%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + L LG G FG+V G + +VA+K+++R + ++ EIQ +K Sbjct: 2 ERPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLL---HQQMLQSEIQAMK 57 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK--HGRVEEMEARRLFQQILSAV 127 RH HI+ LY V+S +++ E ++ G L + + + E + Q+ + Sbjct: 58 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM 117 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-YAAPEVIS 186 Y +HRDL N+L+ + K+ DFGL+ ++ + +L P + APE +S Sbjct: 118 CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS 177 Query: 187 GRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATL 244 R + + D+WS G++L+ + G +P+ F ++ G P SV L Sbjct: 178 -RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKL 236 Query: 245 LMHMLQVDPLKRATIKDIRE 264 ++ DP +R T K +RE Sbjct: 237 MLTCWCRDPEQRPTFKALRE 256 >1V0B-A nrPDB Length = 288 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 128/290 (44%), Gaps = 34/290 (11%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y + +G GT+G V ++ G A+K + +K + REI LK + Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEK-EDEGIPSTTIREISILKELK 58 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCH 131 H +I+KLY VI T +V E++ +L + G +E + A+ Q+L+ + YCH Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLD-QDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH 117 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLY 190 V+HRDLKP+N+L++ KIADFGL+ + Y AP+V+ G Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG-----------GVFYIPEY--- 236 +DIWS G I ++ G F +I V +P+Y Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 237 ---------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 L+ S LL ML++DP +R T K EH +FK++ Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >4AT3-A nrPDB Length = 299 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 76/276 (27%), Positives = 115/276 (41%), Gaps = 27/276 (9%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEH-----QLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 +K + VL LG G FGKV + E + VAVK L S + RE Sbjct: 9 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA---SDNARKDFHRE 65 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-------------V 111 + L +H HI+K Y V MV EY+ G+L ++ HG + Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 112 EEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR 171 + + + QQI + + Y VHRDL N L+ ++ KI DFG+S + ++ R Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYR 185 Query: 172 TSCGS---PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR 227 + + PE I R + E D+WS GV+L+ + G P+ + + I Sbjct: 186 VGGHTMLPIRWMPPESIMYRKFTT-ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT 244 Query: 228 GGV-FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G P + V L++ Q +P R IK I Sbjct: 245 QGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 280 >2WTK-C nrPDB Length = 305 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 101/300 (33%), Positives = 158/300 (52%), Gaps = 10/300 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRS-LDVVGKIKREIQNLKLF 71 IG Y++GD LG G++GKVK T + AVKIL ++K+R + +K+EIQ L+ Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 72 RHPHIIKLYQVI--STPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAV 127 RH ++I+L V+ +MVMEY G E+ D + + R +A F Q++ + Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPE-KRFPVCQAHGYFCQLIDGL 122 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD---GEFLRTSCGSPNYAAPEV 184 +Y H +VH+D+KP N+LL KI+ G++ + + RTS GSP + PE+ Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 185 ISG-RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 +G ++G +VDIWS GV LY + G PF+ +++ LF+ I G + IP ++ Sbjct: 183 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 242 Query: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECT 303 LL ML+ +P KR +I+ IR+H WF++ P P + D V E Sbjct: 243 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDL 302 >2VD5-A nrPDB Length = 412 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 130/296 (43%), Gaps = 22/296 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R++ + + +G G F +V + + + TG A+KI+N+ + V + E L Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVD 128 I +L+ ++VMEY GG+L + K G R+ AR +I+ A+D Sbjct: 117 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 176 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT--SCGSPNYAAPEVIS 186 HR VHRD+KP+N+LLD + ++ADFG + +R+ + G+P+Y +PE++ Sbjct: 177 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 236 Query: 187 ------GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIR--GGVFYIP---E 235 G GPE D W+ GV Y + G PF + + KI +P E Sbjct: 237 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 296 Query: 236 YLNRSVATLLMHMLQVDPLKRA---TIKDIREHEWF----KQDLPSYLFPEDPSYD 284 + + +L P R D R H +F L + P P ++ Sbjct: 297 GVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFE 351 >3NYO-A nrPDB Length = 576 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 135/308 (43%), Gaps = 22/308 (7%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V + LG G FG+V + + TG A K L +++I+ E Q L+ Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVD 128 ++ L T +V+ ++GG+L +I G+ E A +I ++ Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 HR +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY----LNRSVATL 244 Y D W+ G +LY ++ G PF +++ V +PE + +L Sbjct: 361 RYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 Query: 245 LMHMLQVDPLKRA-----TIKDIREHEWFKQ----------DLPSYLFPEDPSYDANVID 289 +L DP +R + ++++EH FK+ P + Y +V+D Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 Query: 290 DEAVKEVC 297 E V Sbjct: 480 IEQFSTVK 487 >3GC9-A nrPDB Length = 370 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 134/328 (40%), Gaps = 44/328 (13%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 +G G +G V KVAVK L+R +SL + RE++ LK +H ++I Sbjct: 33 LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLLKHLKHENVIG 91 Query: 79 LYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 L V + T + ++V + G +L + I K + + + L Q+L + Y H Sbjct: 92 LLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKSQALSDEHVQFLVYQLLRGLKYIHS 149 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 ++HRDLKP NV ++ +I DFGL+ E + + Y APE++ ++ Sbjct: 150 AGIIHRDLKPSNVAVNEDSELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYN 207 Query: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGGVFY 232 VDIWS G I+ LL G F K+I R + Sbjct: 208 QTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS 267 Query: 233 IPEYLNRS-----------VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDP 281 +P + LL ML +D +R + + H +F Q PE Sbjct: 268 LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE 327 Query: 282 SYDANVIDDEAVKEVCEKFECTESEVMN 309 YD +V + + + E E T EV++ Sbjct: 328 PYDESV--EAKERTLEEWKELTYQEVLS 353 >4E93-A nrPDB Length = 377 Score = 258 bits (660), Expect = 4e-69, Method: Composition-based stats. Identities = 68/264 (25%), Positives = 120/264 (45%), Gaps = 9/264 (3%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 K + VLG+ +G G FG+V G + VAVK + ++ D+ K +E Sbjct: 105 PKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK--SCRETLPPDLKAKFLQE 162 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQI 123 + LK + HP+I++L V + ++VME V GG+ ++ G R+ ++ Sbjct: 163 ARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDA 222 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC---GSPNYA 180 + ++Y +HRDL N L+ KI+DFG+S +DG + + + Sbjct: 223 AAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWT 282 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLN 238 APE ++ Y+ E D+WS G++L+ G P+ + + + +GG PE Sbjct: 283 APEALNYGRYSS-ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 341 Query: 239 RSVATLLMHMLQVDPLKRATIKDI 262 +V L+ +P +R + I Sbjct: 342 DAVFRLMEQCWAYEPGQRPSFSTI 365 >4KRC-A nrPDB Length = 317 Score = 258 bits (659), Expect = 5e-69, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 119/298 (39%), Gaps = 44/298 (14%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + + LG GT+ V G ++ TG VA+K + REI +K +H Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELKH 62 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH------GRVEEMEARRLFQQILSAV 127 +I++LY VI T +V E++ +L Y+ +E + Q+L + Sbjct: 63 ENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGL 121 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 186 +CH + ++HRDLKP+N+L++ K+ DFGL+ + + Y AP+V+ Sbjct: 122 AFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK------------------KIRG 228 G +DIWSCG IL ++ G F + K K+ Sbjct: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Query: 229 GVFYIPEYLNRSVA----------------TLLMHMLQVDPLKRATIKDIREHEWFKQ 270 I + R + L +LQ++P R + K H WF + Sbjct: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >1JNK-A nrPDB Length = 423 Score = 257 bits (658), Expect = 7e-69, Method: Composition-based stats. Identities = 83/348 (23%), Positives = 126/348 (36%), Gaps = 57/348 (16%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVN 119 Query: 73 HPHIIKLYQVI------STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 H +II L V D ++VME + L I ++ L Q+L Sbjct: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCG 176 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV---------------- 230 G Y VDIWS G I+ ++ + F + K+ + Sbjct: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Query: 231 -----------FYIPEYLNRS---------------VATLLMHMLQVDPLKRATIKDIRE 264 P+ S LL ML +DP KR ++ D + Sbjct: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 Query: 265 HEWFK--QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 H + D P YD + DE + E E EVMNS Sbjct: 356 HPYINVWYDPAEVEAPPPQIYDKQL--DEREHTIEEWKELIYKEVMNS 401 >3E7O-A nrPDB Length = 360 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 87/347 (25%), Positives = 132/347 (38%), Gaps = 57/347 (16%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y +G G G V + G VAVK L+R ++ + RE+ LK Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP-FQNQTHAKRAYRELVLLKCVN 79 Query: 73 HPHIIKLYQVI------STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 H +II L V D ++VME + L I H ++ L Q+L Sbjct: 80 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVI--HMELDHERMSYLLYQMLCG 136 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + + H ++HRDLKP N+++ + KI DFGL+ S + + Y APEVI Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVIL 196 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-------------- 232 G Y VDIWS G I+ L+ G++ F + K+ + Sbjct: 197 GMGY-KENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVR 255 Query: 233 -----------------IPEYLNRS-----------VATLLMHMLQVDPLKRATIKDIRE 264 P+++ S LL ML +DP KR ++ + Sbjct: 256 NYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALR 315 Query: 265 HEWFK--QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 309 H + D P YDA + +E + E E EVM+ Sbjct: 316 HPYITVWYDPAEAEAPPPQIYDAQL--EEREHAIEEWKELIYKEVMD 360 >4IC8-A nrPDB Length = 442 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 49/329 (14%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y + +T+G G +G V +LTG +VA+K + + + RE++ LK F+H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHFKH 113 Query: 74 PHIIKLYQV------ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 +II + + ++V++ + +L I + R Q+L + Sbjct: 114 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 172 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-----SDGEFLRTSCGSPNYAAP 182 Y H V+HRDLKP N+L++ + KI DFG++ + F+ + Y AP Sbjct: 173 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 232 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDE---HVPTLF---------------- 223 E++ +D+WS G I +L F + H L Sbjct: 233 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 292 Query: 224 -KKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ- 270 +++R + +P +R +LL ML+ +P R + H + + Sbjct: 293 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 352 Query: 271 ----DLPSYLFPEDPSYDANVIDDEAVKE 295 D P P D ++D + E +KE Sbjct: 353 HDPDDEPDCAPPFDFAFDREALTRERIKE 381 >3BBT-B nrPDB Length = 328 Score = 257 bits (657), Expect = 1e-68, Method: Composition-based stats. Identities = 78/321 (24%), Positives = 130/321 (40%), Gaps = 26/321 (8%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGH----KVAVKILNRQKIRSLDVVGKIKREIQ 66 +K LG G FG V G G VA+KILN +V + E Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANV--EFMDEAL 69 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILS 125 + HPH+++L V +PT +V + + G L +Y+ +H + QI Sbjct: 70 IMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAK 128 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAP 182 + Y +VHRDL NVL+ + + KI DFGL+ ++ E + G + A Sbjct: 129 GMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMAL 188 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRS 240 E I R + + D+WS GV ++ L+ G P+D + + G P Sbjct: 189 ECIHYRKFTH-QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTID 247 Query: 241 VATLLMHMLQVDPLKRATIKDI-REHEWFKQDLPSYLF-----------PEDPSYDANVI 288 V +++ +D R K++ E +D YL P D + N++ Sbjct: 248 VYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLL 307 Query: 289 DDEAVKEVCEKFECTESEVMN 309 D+E ++++ + E + N Sbjct: 308 DEEDLEDMMDAEEYLVPQAFN 328 >5UUU-A nrPDB Length = 547 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 138/311 (44%), Gaps = 23/311 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + + + + +G G FG+V TG A+K L++++I+ E L Sbjct: 194 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 253 Query: 70 LF---RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 L P I+ + TP +++ ++GG+L ++ +HG E + R +I+ Sbjct: 254 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 +++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 314 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQ 372 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 + D +S G +L+ LL G PF + + + +P+ + + + Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 432 Query: 244 LLMHMLQVDPLKRA-----TIKDIREHEWFK---------QDLPSYLFPEDPSYDANVID 289 LL +LQ D +R ++++E +F+ Q P L P P + N D Sbjct: 433 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 490 Query: 290 DEAVKEVCEKF 300 + E+ Sbjct: 491 AFDIGSFDEED 501 >5EFQ-A nrPDB Length = 347 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 132/315 (41%), Gaps = 45/315 (14%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ + + + +G GT+G+V + TG VA+K + + + I REI+ L Sbjct: 6 GKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAI-REIKIL 64 Query: 69 KLFRHPHIIKLYQVISTPTD----------FFMVMEYVSGGELFDYICKH-GRVEEMEAR 117 + H II + ++++ D F++V EY+ +L + E + Sbjct: 65 RQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIK 123 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSCG 175 +Q++ +DYCH+ +HRD+K N+LL+ K+ADFGL+ + S E Sbjct: 124 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 176 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH---VPTLFKKIRG---- 228 + Y PE++ G P +D+WSCG IL L F L +I G Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCP 243 Query: 229 ----GVFYIPE-------------------YLNRSVATLLMHMLQVDPLKRATIKDIREH 265 V +P ++ + L +ML +DP KR T + + Sbjct: 244 AVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQC 303 Query: 266 EWFKQDLPSYLFPED 280 E+ + PS + P D Sbjct: 304 EFLRDVEPSKMPPPD 318 >4ZSG-A nrPDB Length = 347 Score = 256 bits (655), Expect = 2e-68, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 49/329 (14%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y + +T+G G +G V +LTG +VA+K + + + RE++ LK F+H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHFKH 65 Query: 74 PHIIKLYQV------ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 +II + + ++V++ + +L I + R Q+L + Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGL 124 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-----SDGEFLRTSCGSPNYAAP 182 Y H V+HRDLKP N+L++ + KI DFG++ + F+ + Y AP Sbjct: 125 KYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAP 184 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDE---HVPTLF---------------- 223 E++ +D+WS G I +L F + H L Sbjct: 185 ELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVG 244 Query: 224 -KKIRGGVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ- 270 +++R + +P +R +LL ML+ +P R + H + + Sbjct: 245 AERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKY 304 Query: 271 ----DLPSYLFPEDPSYDANVIDDEAVKE 295 D P P D ++D + E +KE Sbjct: 305 HDPDDEPDCAPPFDFAFDREALTRERIKE 333 >3OZ6-A nrPDB Length = 388 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 85/380 (22%), Positives = 132/380 (34%), Gaps = 80/380 (21%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-H 73 Y L LG G +G V + TG VAVK + ++ + REI L H Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIMILTELSGH 68 Query: 74 PHIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 +I+ L V+ D ++V +Y+ +L I + +E + + + Q++ + Y H Sbjct: 69 ENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRAN-ILEPVHKQYVVYQLIKVIKYLH 126 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM----------------------SDGEF 169 ++HRD+KP N+LL+A + K+ADFGLS D Sbjct: 127 SGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPI 186 Query: 170 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG 229 L + Y APE++ G +D+WS G IL +LCG F ++I G Sbjct: 187 LTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERII-G 245 Query: 230 VFYIPEY------------------------------------------------LNRSV 241 V P N Sbjct: 246 VIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEA 305 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301 LL +LQ +P KR + D +H + P I+D + + Sbjct: 306 LDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSIDDYRN 365 Query: 302 CTESEVMNS---LYSGDPQD 318 SE+ L S Q+ Sbjct: 366 LVYSEISRRKRELISNKHQN 385 >2J0K-A nrPDB Length = 656 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 72/265 (27%), Positives = 116/265 (43%), Gaps = 12/265 (4%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKR 63 D ++ LG +G G FG V G + + VA+K S V K + Sbjct: 383 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK--NCTSDSVREKFLQ 440 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQ 122 E ++ F HPHI+KL VI T +++ME + GEL ++ ++ Q Sbjct: 441 EALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQ 499 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP--NYA 180 + +A+ Y VHRD+ NVL+ A K+ DFGLS M D + + S G + Sbjct: 500 LSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 559 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLN 238 APE I+ R + D+W GV ++ +L G PF + +I G +P Sbjct: 560 APESINFRRFTSA-SDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP 618 Query: 239 RSVATLLMHMLQVDPLKRATIKDIR 263 ++ +L+ DP +R +++ Sbjct: 619 PTLYSLMTKCWAYDPSRRPRFTELK 643 >4MYG-A nrPDB Length = 372 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 134/328 (40%), Gaps = 50/328 (15%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G +G V + +G KVA+K L+R +S + RE+ LK +H ++I L Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 82 VISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 V + + DF++VM ++ +L + E + + L Q+L + Y H V Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAGV 166 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 VHRDLKP N+ ++ KI DFGL+ + + Y APEVI ++ V Sbjct: 167 VHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTV 224 Query: 196 DIWSCGVILYALLCGTLPFDDEHVPTLFKKI--------------------RGGVFYIP- 234 DIWS G I+ +L G F + +I + + +P Sbjct: 225 DIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQ 284 Query: 235 ----------EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYD 284 + A LL ML++D KR T H +F+ + PE+ + Sbjct: 285 TPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE----PFRDPEEETEA 340 Query: 285 ANVIDDEAVKE---VCEKFECTESEVMN 309 DD E V E + E++N Sbjct: 341 QQPFDDSLEHEKLTVDEWKQHIYKEIVN 368 >2BRG-A nrPDB Length = 297 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 147/266 (55%), Gaps = 8/266 (3%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + L TLG G +G+V++ +++T VAVKI++ + R++D IK+EI K+ Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMK--RAVDCPENIKKEICINKMLN 63 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H +++K Y ++ +EY SGGELFD I + E +A+R F Q+++ V Y H Sbjct: 64 HENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHG 123 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRL 189 + HRD+KPEN+LLD N KI+DFGL+ + L CG+ Y APE++ R Sbjct: 124 IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRRE 183 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVP-TLFKKIRGGVFYIPEY--LNRSVATLLM 246 + VD+WSCG++L A+L G LP+D + + Y+ + ++ + LL Sbjct: 184 FHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLH 243 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 +L +P R TI DI++ W+ + L Sbjct: 244 KILVENPSARITIPDIKKDRWYNKPL 269 >5D7A-A nrPDB Length = 308 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 71/279 (25%), Positives = 122/279 (43%), Gaps = 20/279 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R G + L + +G GT+G+V G H TG A+K+++ D +IK+EI LK Sbjct: 13 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG----DEEEEIKQEINMLK 68 Query: 70 LF-RHPHIIKLYQVIST------PTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLF 120 + H +I Y ++VME+ G + D I K ++E + Sbjct: 69 KYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYIC 128 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNY 179 ++IL + + H+H V+HRD+K +NVLL + K+ DFG+S + R T G+P + Sbjct: 129 REILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 188 Query: 180 AAPEVISGRLY----AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI-- 233 APEVI+ + D+WS G+ + G P D H I Sbjct: 189 MAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLK 248 Query: 234 PEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDL 272 + ++ + + L + +R + + +H + + Sbjct: 249 SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQP 287 >4UY9-A nrPDB Length = 323 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 125/306 (40%), Gaps = 22/306 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV-VGKIKREIQNL 68 + L + +G+G FGKV G +VAVK + + +++E + Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 62 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 + +HP+II L V + +VME+ GG L + + R+ QI ++ Sbjct: 63 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMN 121 Query: 129 YCHRH---MVVHRDLKPENVLL--------DAHMNAKIADFGLSNMMSDGEFLRTSCGSP 177 Y H ++HRDLK N+L+ ++ KI DFGL+ + ++ G+ Sbjct: 122 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGTY 180 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--FYIPE 235 + APEVI ++ D+WS GV+L+ LL G +PF + + IP Sbjct: 181 AWMAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 239 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKE 295 A L+ DP R + +I + S F P + + D E Sbjct: 240 TCPEPFAKLMEDCWNPDPHSRPSFTNILDQ--LTTIEESGFFEM-PKDSFHCLQDNWKHE 296 Query: 296 VCEKFE 301 + E F+ Sbjct: 297 IQEMFD 302 >3PVW-A nrPDB Length = 695 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 138/311 (44%), Gaps = 23/311 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + + + + +G G FG+V TG A+K L++++I+ E L Sbjct: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 Query: 70 LF---RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 L P I+ + TP +++ ++GG+L ++ +HG E + R +I+ Sbjct: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 +++ H VV+RDLKP N+LLD H + +I+D GL+ S + S G+ Y APEV+ Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQ 363 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPF---DDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 + D +S G +L+ LL G PF + + + +P+ + + + Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Query: 244 LLMHMLQVDPLKRA-----TIKDIREHEWFK---------QDLPSYLFPEDPSYDANVID 289 LL +LQ D +R ++++E +F+ Q P L P P + N D Sbjct: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP--PRGEVNAAD 481 Query: 290 DEAVKEVCEKF 300 + E+ Sbjct: 482 AFDIGSFDEED 492 >3TT0-A nrPDB Length = 382 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 32/286 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIG------EHQLTG-HKVAVKILNRQKIRSLDVVGKI 61 + VLG LG G FG+V + + + KVAVK+L + + Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK--DLSDL 121 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ +K+ +H +II L + ++++EY S G L +Y+ Sbjct: 122 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPS 181 Query: 110 -----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 ++ + Q+ ++Y +HRDL NVL+ KIADFGL+ + Sbjct: 182 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 241 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 ++ + + + APE + R+Y + D+WS GV+L+ + G P+ V Sbjct: 242 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVE 300 Query: 221 TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LFK ++ G P + ++ P +R T K + E Sbjct: 301 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >4OTD-A nrPDB Length = 341 Score = 254 bits (650), Expect = 6e-68, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 137/301 (45%), Gaps = 13/301 (4%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 + + + LG G FGKV + E + +G A+K L + I + D V + E + L Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 71 F---RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 127 HP ++ L+ TP VMEY +GG+L +I E A ++ + Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGL 127 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVIS 186 + H H +V+RDLK +N+LLD KIADFGL M G+ T CG+P + APEV++ Sbjct: 128 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 187 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y VD W GV+LY +L G PF + +F I P +L+ ++ Sbjct: 188 DTSYT-RAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMR 246 Query: 247 HMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVKEVCEK 299 +L+ +P +R +D+++ +F+ L P + + V E+ Sbjct: 247 RLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEE 306 Query: 300 F 300 F Sbjct: 307 F 307 >2UV2-A nrPDB Length = 325 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 129/301 (42%), Gaps = 21/301 (6%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + + LG G FGKV +++ T A K+++ +S + + EI L H Sbjct: 37 DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---TKSEEELEDYMVEIDILASCDH 93 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHR 132 P+I+KL + ++++E+ +GG + + + R + E + + + +Q L A++Y H Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVIS----G 187 + ++HRDLK N+L + K+ADFG+ + + + G+P + APEV+ Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY---IPEYLNRSVATL 244 + D+WS G+ L + P + + + KI P + + Sbjct: 214 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDF 273 Query: 245 LMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTE 304 L L+ + R T + +H + D + + EA EV E+ E + Sbjct: 274 LKKCLEKNVDARWTTSQLLQHPFVTVD---------SNKPIRELIAEAKAEVTEEVEDGK 324 Query: 305 S 305 Sbjct: 325 E 325 >4P5Q-A nrPDB Length = 361 Score = 254 bits (649), Expect = 8e-68, Method: Composition-based stats. Identities = 66/264 (25%), Positives = 118/264 (44%), Gaps = 13/264 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + + + +G G FG+V G +L K VA+K L E Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK--QRRDFLGEAS 86 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILS 125 + F HP+II+L V++ +V EY+ G L ++ KH + ++ + + I S Sbjct: 87 IMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIAS 146 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAA 181 + Y VHRDL N+L+++++ K++DFGLS ++ D E T+ G + + Sbjct: 147 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTS 206 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 239 PE I+ R + D+WS G++L+ ++ G P+ + + K + G P Sbjct: 207 PEAIAYRKFTSA-SDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPA 265 Query: 240 SVATLLMHMLQVDPLKRATIKDIR 263 ++ L++ Q D R + I Sbjct: 266 ALYQLMLDCWQKDRNNRPKFEQIV 289 >6HXF-B nrPDB Length = 302 Score = 254 bits (649), Expect = 8e-68, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 119/263 (45%), Gaps = 12/263 (4%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 + + LG G FGKV +++ TG A K++ + +S + + EI+ L HP+ Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVI---ETKSEEELEDYIVEIEILATCDHPY 77 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 134 I+KL ++++E+ GG + + + R + E + + + +Q+L A+++ H Sbjct: 78 IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKR 137 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVI----SGRL 189 ++HRDLK NVL+ + ++ADFG+ + + + + G+P + APEV+ Sbjct: 138 IIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDT 197 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY---IPEYLNRSVATLLM 246 + DIWS G+ L + P + + + KI P + L Sbjct: 198 PYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 257 Query: 247 HMLQVDPLKRATIKDIREHEWFK 269 L +P R + + EH + Sbjct: 258 IALDKNPETRPSAAQLLEHPFVS 280 >2WQN-A nrPDB Length = 310 Score = 254 bits (648), Expect = 9e-68, Method: Composition-based stats. Identities = 70/260 (26%), Positives = 116/260 (44%), Gaps = 10/260 (3%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G + ++ + +G G F +V L G VA+K + + +EI L Sbjct: 27 GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLL 86 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQIL 124 K HP++IK Y + +V+E G+L I + + E + F Q+ Sbjct: 87 KQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD-GEFLRTSCGSPNYAAPE 183 SA+++ H V+HRD+KP NV + A K+ D GL S + G+P Y +PE Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFKKIRGGVF-YIP-EYLNR 239 I Y + DIWS G +LY + PF + ++ +L KKI + +P ++ + Sbjct: 207 RIHENGY-NFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSE 265 Query: 240 SVATLLMHMLQVDPLKRATI 259 + L+ + DP KR + Sbjct: 266 ELRQLVNMCINPDPEKRPDV 285 >6BXI-A nrPDB Length = 333 Score = 254 bits (648), Expect = 9e-68, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 139/333 (41%), Gaps = 47/333 (14%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R+ + + +G G FG+V++ + + TGH A+KIL + + + VG I+ E L Sbjct: 2 RLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 61 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 ++K++ + +++ME++ GG++ + K + E E + + + A+D Sbjct: 62 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLR--------------- 171 H+ +HRD+KP+N+LLD+ + K++DFGL EF R Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 172 ------------------TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP 213 ++ G+P+Y APEV Y D WS GVI+Y +L G P Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGY-NKLCDWWSLGVIMYEMLIGYPP 240 Query: 214 FDDEHVPTLFKKIRG--GVFYIPEY--LNRSVATLLMH-MLQVDPLKRATI---KDIREH 265 F E +KK+ P ++ L++ + R ++I+ + Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEW--EHRIGAPGVEEIKSN 298 Query: 266 EWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 298 +F+ ++ + + + E Sbjct: 299 SFFEGVDWEHIRERPAAISIEIKSIDDTSNFDE 331 >4TNB-A nrPDB Length = 590 Score = 254 bits (648), Expect = 9e-68, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 130/308 (42%), Gaps = 22/308 (7%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V + LG G FG+V + + TG A K L +++I+ E Q L+ Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAVD 128 ++ L T +V+ ++GG+L +I G EE A +IL ++ Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 H V+RDLKPEN+LLD + + +I+D GL+ + +G+ +R G+ Y APEV++ + Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHV----PTLFKKIRGGVFYIPEYLNRSVATL 244 Y G D W G ++Y ++ G PF + +++ + ++ Sbjct: 361 RY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 Query: 245 LMHMLQVDPLKRAT-----IKDIREHEWFKQ----------DLPSYLFPEDPSYDANVID 289 +L D +R +++ H +F+ P ++ Y +V+D Sbjct: 420 CKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479 Query: 290 DEAVKEVC 297 E V Sbjct: 480 IEQFSTVK 487 >5KMM-A nrPDB Length = 329 Score = 254 bits (648), Expect = 9e-68, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 117/295 (39%), Gaps = 34/295 (11%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQ-----LTGHKVAVKILNRQKIRSLDVVGKIKRE 64 +K VL LG G FGKV + E VAVK L S +RE Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA---SESARQDFQRE 87 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH---------------G 109 + L + +H HI++ + V + MV EY+ G+L ++ H G Sbjct: 88 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 110 RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 169 + + + Q+ + + Y VHRDL N L+ + KI DFG+S + ++ Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 170 LRTSCGS---PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKK 225 R + + PE I R + E D+WS GV+L+ + G P+ Sbjct: 208 YRVGGRTMLPIRWMPPESILYRKFTT-ESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC 266 Query: 226 IRGGV-FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK---QDLPSYL 276 I G P V ++ Q +P +R +IKD+ H + Q P YL Sbjct: 267 ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV--HARLQALAQAPPVYL 319 >3DKO-A nrPDB Length = 318 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 64/264 (24%), Positives = 119/264 (45%), Gaps = 13/264 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + + +G G FG+V G +L G + VA+K L E Sbjct: 39 ELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK--QRRDFLCEAS 96 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F HP+++ L V++ +V+E++ G L ++ KH G+ ++ + + I + Sbjct: 97 IMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAA 156 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAA 181 + Y VHRDL N+L+++++ K++DFGLS ++ D E + T+ G + A Sbjct: 157 GMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTA 216 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNR 239 PE I R + D+WS G++++ ++ G P+ D + K I G P Sbjct: 217 PEAIQYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPA 275 Query: 240 SVATLLMHMLQVDPLKRATIKDIR 263 + L++ Q + +R + I Sbjct: 276 GLHQLMLDCWQKERAERPKFEQIV 299 >4XCU-A nrPDB Length = 300 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 69/276 (25%), Positives = 114/276 (41%), Gaps = 23/276 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEH------QLTG-HKVAVKILNRQKIRSLDVVGKI 61 VLG LG G FG+V E + VAVK+L S + + Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNA--SDKDLADL 69 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-------GRVEE 113 E++ +KL RH +II L V + ++++E + G L +++ G + Sbjct: 70 VSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSF 129 Query: 114 MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS 173 Q+ + Y +HRDL NVL+ KIADFGL+ + ++ + + Sbjct: 130 PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKT 189 Query: 174 CGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG 229 + APE + R+Y + D+WS G++L+ + G P+ V LF +R G Sbjct: 190 SNGRLPVKWMAPEALFDRVYTH-QSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 248 Query: 230 -VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 P + + L+ P +R T K + E Sbjct: 249 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >2F9G-A nrPDB Length = 353 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 125/337 (37%), Gaps = 52/337 (15%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + L LG G +G V H+ TG VA+K + + + REI+ LK F+H Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI--EPFDKPLFALRTLREIKILKHFKH 68 Query: 74 PHIIKLY-----QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +II ++ + +++ E + +L I + + + Q L AV Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQ-MLSDDHIQYFIYQTLRAVK 126 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----------LRTSCGSP 177 H V+HRDLKP N+L++++ + K+ DFGL+ ++ + + + Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI----------- 226 Y APEV+ +D+WSCG IL L F I Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 227 ----------RGGVFYIP-----------EYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 R + +P +N LL ML DP KR T K+ EH Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 266 EWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFEC 302 + + PE + + + KE + Sbjct: 307 PYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDL 343 >4X7Q-B nrPDB Length = 312 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 82/278 (29%), Positives = 134/278 (48%), Gaps = 18/278 (6%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR---EIQNLKL 70 Y LG LG G FG V G +VA+K++ R ++ + E+ L Sbjct: 31 AEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWK 90 Query: 71 FR----HPHIIKLYQVISTPTDFFMVMEY-VSGGELFDYICKHGRVEEMEARRLFQQILS 125 HP +I+L T F +V+E + +LFDYI + G + E +R F Q+++ Sbjct: 91 VGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVA 150 Query: 126 AVDYCHRHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 A+ +CH VVHRD+K EN+L+D AK+ DFG ++ D E G+ Y+ PE Sbjct: 151 AIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPEW 209 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATL 244 IS Y +WS G++LY ++CG +PF+ + ++I + P +++ L Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELHFPAHVSPDCCAL 263 Query: 245 LMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPS 282 + L P R ++++I W + P+ P +PS Sbjct: 264 IRRCLAPKPSSRPSLEEILLDPWMQ--TPAEDVPLNPS 299 >3SXS-A nrPDB Length = 268 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 126/260 (48%), Gaps = 13/260 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 +K L LG G FG VK+G+ + + VAVK++ + + +E Q + Sbjct: 4 ELKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMSEDE----FFQEAQTMM 58 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVD 128 HP ++K Y V S ++V EY+S G L +Y+ HG+ +E + + + + Sbjct: 59 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMA 118 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVI 185 + H +HRDL N L+D + K++DFG++ + D +++ +S G+ ++APEV Sbjct: 119 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYV-SSVGTKFPVKWSAPEVF 177 Query: 186 SGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVAT 243 Y+ + D+W+ G++++ + G +P+D + K+ G Y P + ++ Sbjct: 178 HYFKYSS-KSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQ 236 Query: 244 LLMHMLQVDPLKRATIKDIR 263 ++ P KR T + + Sbjct: 237 IMYSCWHELPEKRPTFQQLL 256 >1JPA-A nrPDB Length = 312 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 61/267 (22%), Positives = 114/267 (42%), Gaps = 15/267 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + I + +G G FG+V G +L G + VA+K L E Sbjct: 29 EIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK--QRRDFLSEAS 86 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F HP++I L V++ T ++ E++ G L ++ ++ G+ ++ + + I + Sbjct: 87 IMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAA 146 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSP---NY 179 + Y VHRDL N+L+++++ K++DFGLS + D ++ G + Sbjct: 147 GMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW 206 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYL 237 APE I R + D+WS G++++ ++ G P+ D + I P Sbjct: 207 TAPEAIQYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDC 265 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIRE 264 ++ L++ Q D R I Sbjct: 266 PSALHQLMLDCWQKDRNHRPKFGQIVN 292 >2R2P-A nrPDB Length = 295 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 119/265 (44%), Gaps = 13/265 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 ++ + +G G FG+V G +L G + VA+K L E Sbjct: 18 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK--QRRDFLGEAS 75 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F HP+II L V++ +V EY+ G L ++ K+ G+ ++ + + I + Sbjct: 76 IMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISA 135 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAA 181 + Y VHRDL N+L+++++ K++DFGLS ++ D E T+ G + A Sbjct: 136 GMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTA 195 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNR 239 PE I+ R + D+WS G++++ ++ G P+ + + K + G P Sbjct: 196 PEAIAFRKFTSA-SDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPA 254 Query: 240 SVATLLMHMLQVDPLKRATIKDIRE 264 ++ L++ Q + R +I Sbjct: 255 ALYQLMLDCWQKERNSRPKFDEIVN 279 >3GQL-A nrPDB Length = 326 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 32/286 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIG------EHQLTG-HKVAVKILNRQKIRSLDVVGKI 61 + VLG LG G FG+V + + + KVAVK+L + + Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK--DLSDL 80 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ +K+ +H +II L + ++++EY S G L +Y+ Sbjct: 81 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 140 Query: 110 -----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 ++ + Q+ ++Y +HRDL NVL+ KIADFGL+ + Sbjct: 141 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 200 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 ++ + + + APE + R+Y + D+WS GV+L+ + G P+ V Sbjct: 201 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVE 259 Query: 221 TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LFK ++ G P + ++ P +R T K + E Sbjct: 260 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >3DTC-A nrPDB Length = 271 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 68/268 (25%), Positives = 113/268 (42%), Gaps = 19/268 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV-VGKIKREIQNL 68 + L + +G+G FGKV G +VAVK + + +++E + Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 60 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 + +HP+II L V + +VME+ GG L + + R+ QI ++ Sbjct: 61 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL-NRVLSGKRIPPDILVNWAVQIARGMN 119 Query: 129 YCHRH---MVVHRDLKPENVLL--------DAHMNAKIADFGLSNMMSDGEFLRTSCGSP 177 Y H ++HRDLK N+L+ ++ KI DFGL+ + ++ G+ Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAAGAY 178 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--FYIPE 235 + APEVI ++ D+WS GV+L+ LL G +PF + + IP Sbjct: 179 AWMAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPS 237 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIR 263 A L+ DP R + +I Sbjct: 238 TCPEPFAKLMEDCWNPDPHSRPSFTNIL 265 >6CKI-A nrPDB Length = 316 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 134/301 (44%), Gaps = 39/301 (12%) Query: 16 YVLGD-TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-H 73 Y L + LG G +V+ + +T + AVKI+ +Q + ++ RE++ L + H Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQ---PGHIRSRVFREVEMLYQCQGH 70 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 ++++L + F++V E + GG + +I K E+EA + Q + SA+D+ H Sbjct: 71 RNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNK 130 Query: 134 MVVHRDLKPENVLLDAHMN---AKIADFGLSNMMS--------DGEFLRTSCGSPNYAAP 182 + HRDLKPEN+L + KI DFGL + + L T CGS Y AP Sbjct: 131 GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 190 Query: 183 EVI----SGRLYAGPEVDIWSCGVILYALLCGTLPFDDE---------------HVPTLF 223 EV+ D+WS GVILY LL G PF LF Sbjct: 191 EVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLF 250 Query: 224 KKIRGGVFYIPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 279 + I+ G + P+ +++ + L+ +L D +R + + +H W + P P Sbjct: 251 ESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPT 310 Query: 280 D 280 Sbjct: 311 P 311 >6CCF-A nrPDB Length = 290 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 145/290 (50%), Gaps = 31/290 (10%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ-------------------- 50 +++ Y L +G G +G V++ ++ A+K+L+++ Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 51 ---KIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTP--TDFFMVMEYVSGGELFDYI 105 + L + ++ +EI LK H +++KL +V+ P + ++V + + G + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 121 Query: 106 CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS 165 C E +AR + ++ ++Y H +VHRD+KP N+LL + KIADFG+SN Sbjct: 122 CD-KPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 166 DGE-FLRTSCGSPNYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL 222 + L ++ G+P + APE I SG+ ++G +D+W+ GV LY + G PF D+ + L Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 240 Query: 223 FKKIRGGVFYIPE--YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 +KI+ PE ++ + L++ ML +P R + DI+ H W + Sbjct: 241 HRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >5MJB-A nrPDB Length = 305 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 116/267 (43%), Gaps = 15/267 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + + + + +G G FG+V G +L G + VA+K L S E Sbjct: 22 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK--AGYSEKQRRDFLSEAS 79 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F H +II+L V++ ++ E++ L ++ ++ G+ ++ + + I + Sbjct: 80 IMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAA 139 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSP---NY 179 + Y VHRDL N+L+++++ K++DFGLS + D +S G + Sbjct: 140 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW 199 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYL 237 APE I+ R + D+WS G++++ ++ G P+ D + I P Sbjct: 200 TAPEAIAYRKFTSA-SDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDC 258 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIRE 264 ++ L++ Q D R +I Sbjct: 259 PAALHQLMLDCWQKDRNSRPRFAEIVN 285 >2Y6O-A nrPDB Length = 291 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 119/265 (44%), Gaps = 13/265 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + + +GVG FG+V G ++ G + VA+K L + E Sbjct: 10 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK--AGYTDKQRRDFLSEAS 67 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F HP+II L V++ ++ EY+ G L ++ K+ GR ++ + + I S Sbjct: 68 IMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGS 127 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTSCGSP---NYAA 181 + Y VHRDL N+L+++++ K++DFG+S ++ D E T+ G + A Sbjct: 128 GMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTA 187 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNR 239 PE I+ R + D+WS G++++ ++ G P+ D + K I G P Sbjct: 188 PEAIAYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPI 246 Query: 240 SVATLLMHMLQVDPLKRATIKDIRE 264 ++ L++ Q + R I Sbjct: 247 ALHQLMLDCWQKERSDRPKFGQIVN 271 >4UYA-A nrPDB Length = 340 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 79/326 (24%), Positives = 126/326 (38%), Gaps = 30/326 (9%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKR 63 Q V L + +G G FG+V Q G +VAVK + + + ++R Sbjct: 17 QGSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRR 74 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 E + + RHP+II+L V +V+E+ GG L + R+ QI Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGR-RIPPHVLVNWAVQI 133 Query: 124 LSAVDYCHRH---MVVHRDLKPENVLLDA--------HMNAKIADFGLSNMMSDGEFLRT 172 + Y H ++HRDLK N+LL + KI DFGL+ + T Sbjct: 134 ARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT 193 Query: 173 SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK--KIRGGV 230 G+ + APEVI L+ DIWS GV+L+ LL G +P+ + + Sbjct: 194 -AGAYAWMAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLT 251 Query: 231 FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDD 290 IP A L+ Q DP R + I E + + ++ DD Sbjct: 252 LPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ--LTAIEGAVMTEMPQESFHSMQDD 309 Query: 291 EAVKEVCEKFECTESEVMNSLYSGDP 316 ++ ++ + L + + Sbjct: 310 ---------WKLEIQQMFDELRTKEK 326 >2PL0-A nrPDB Length = 289 Score = 251 bits (642), Expect = 5e-67, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 124/285 (43%), Gaps = 19/285 (6%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + V L + LG G FG+V +G + KVAVK L + + E Sbjct: 17 EWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMSPDA----FLAEANL 71 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILS 125 +K +H +++LY V++ +++ EY+ G L D++ ++ + + QI Sbjct: 72 MKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 130 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE 183 + + +HRDL+ N+L+ ++ KIADFGL+ ++ D E+ R P + APE Sbjct: 131 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 190 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSV 241 I+ + + D+WS G++L ++ G +P+ P + + + RG P+ + Sbjct: 191 AINYGTFT-IKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEEL 249 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286 L+ + P R T + + L + + Y Sbjct: 250 YQLMRLCWKERPEDRPTFD------YLRSVLEDFFTATEGQYQPQ 288 >5X5O-A nrPDB Length = 310 Score = 251 bits (642), Expect = 5e-67, Method: Composition-based stats. Identities = 74/260 (28%), Positives = 114/260 (43%), Gaps = 20/260 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 ++K + G G+FG V + +VAVK L + I++E + L Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILS 59 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 127 + H +II+ Y VI P ++ +V EY S G L+DYI + ++ + + Sbjct: 60 VLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGM 119 Query: 128 DYCHRH---MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 Y H V+HRDLK NV++ A KI DFG S + + + G+ + APEV Sbjct: 120 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPEV 178 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVA 242 I L D +S GV+L+ +L +PF + + + IP RS A Sbjct: 179 IQ-SLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFA 237 Query: 243 TLLMHMLQVDPLKRATIKDI 262 LL + D KR + K I Sbjct: 238 ELLHQCWEADAKKRPSFKQI 257 >5A46-A nrPDB Length = 386 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 32/286 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIG------EHQLTG-HKVAVKILNRQKIRSLDVVGKI 61 + VLG LG G FG+V + + + KVAVK+L + + Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK--DLSDL 92 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ +K+ +H +II L + ++++EY S G L +Y+ Sbjct: 93 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 152 Query: 110 -----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 ++ + Q+ ++Y +HRDL NVL+ KIADFGL+ + Sbjct: 153 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI 212 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 ++ + + + APE + R+Y + D+WS GV+L+ + G P+ V Sbjct: 213 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTH-QSDVWSFGVLLWEIFTLGGSPYPGVPVE 271 Query: 221 TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LFK ++ G P + ++ P +R T K + E Sbjct: 272 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >4NST-A nrPDB Length = 351 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 132/318 (41%), Gaps = 45/318 (14%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ + + + +G GT+G+V + + TG VA+K + + + I REI+ L Sbjct: 8 GKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAI-REIKIL 66 Query: 69 KLFRHPHIIKLYQVISTPTD----------FFMVMEYVSGGELFDYICKH-GRVEEMEAR 117 + H ++ + ++++ D F++V EY+ +L + E + Sbjct: 67 RQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIK 125 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSCG 175 +Q++ ++YCH+ +HRD+K N+LL+ K+ADFGL+ + + E Sbjct: 126 SFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 176 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG------- 228 + Y PE++ G P +D+WSCG IL L F + I Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCP 245 Query: 229 ----GVFYIP-------------------EYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 V +P ++ + LL HML +DP KR T + + Sbjct: 246 AVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 305 Query: 266 EWFKQDLPSYLFPEDPSY 283 ++ K S + P D + Sbjct: 306 DFLKDVELSKMAPPDLPH 323 >3HKO-A nrPDB Length = 345 Score = 251 bits (640), Expect = 8e-67, Method: Composition-based stats. Identities = 86/310 (27%), Positives = 133/310 (42%), Gaps = 54/310 (17%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR--SLDVVGKIKREIQNLKLFR 72 Y L +G G++G V++ T A+KI+N+ KIR + V +IK E++ +K Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYI-------------------------CK 107 HP+I +LY+V +VME GG L D + C Sbjct: 87 HPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECN 146 Query: 108 HGRVE---------------EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH-- 150 + E + +QI SA+ Y H + HRD+KPEN L + Sbjct: 147 EEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS 206 Query: 151 MNAKIADFGLSNM---MSDGEFL--RTSCGSPNYAAPEVIS-GRLYAGPEVDIWSCGVIL 204 K+ DFGLS +++GE+ T G+P + APEV++ GP+ D WS GV+L Sbjct: 207 FEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL 266 Query: 205 YALLCGTLPFDDEHVPTLFKKIRGGVFYI--PEY--LNRSVATLLMHMLQVDPLKRATIK 260 + LL G +PF + ++ P Y L+ LL ++L + +R Sbjct: 267 HLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAM 326 Query: 261 DIREHEWFKQ 270 +H W Q Sbjct: 327 RALQHPWISQ 336 >4QNY-A nrPDB Length = 354 Score = 251 bits (640), Expect = 9e-67, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 129/332 (38%), Gaps = 41/332 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 Y+L +G G++G V + VA+K +N++ + + +I REI+ L F Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 72 RHPHIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 +II L +++ F++VM+ + +L + + E + Q L A Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQALRA 137 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD-GEFLRTSCGSPNYAAPEVI 185 + H V+HRD+ P N+L++ + + KI DFGL+ +D GE++ Y APE++ Sbjct: 138 LHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELV 197 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY--------- 236 ++D+W G IL LL F + KI + E Sbjct: 198 MEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSA 257 Query: 237 ----------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 + LL HML +P +R T+ H + +Q Sbjct: 258 AQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDD 317 Query: 275 YLFPEDPSYDANVIDDEAVKEVCEKFECTESE 306 ++ SY D+ K + + E Sbjct: 318 AD--DNLSYALFRFDENEQKTIVDVKRAIYEE 347 >2XS0-A nrPDB Length = 386 Score = 250 bits (638), Expect = 2e-66, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 125/345 (36%), Gaps = 53/345 (15%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVN 83 Query: 73 HPHIIKLYQVI------STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 H +II L V D ++VME + L I ++ L Q+L Sbjct: 84 HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCG 140 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVIL 200 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGVFYIPEYLNR------ 239 G Y VDIWS G I+ ++ G + F +H+ K I PE++ + Sbjct: 201 GMGY-KENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVR 259 Query: 240 -----------------------------------SVATLLMHMLQVDPLKRATIKDIRE 264 LL ML +D KR ++ + + Sbjct: 260 TYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQ 319 Query: 265 HEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMN 309 H + P + DE + E E EVM+ Sbjct: 320 HPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD 364 >4GS6-A nrPDB Length = 315 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 135/327 (41%), Gaps = 31/327 (9%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 + + + +G G FG V + + VA+K +I S E++ L Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIK-----QIESESERKAFIVELRQLSR 58 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV---EEMEARRLFQQILSAV 127 HP+I+KLY P +VMEY GG L++ + + A Q V Sbjct: 59 VNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 128 DYCHRHM---VVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Y H ++HRDLKP N+LL A KI DFG + + + + GS + APE Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT--HMTNNKGSAAWMAPE 174 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP--TLFKKIRGG-VFYIPEYLNRS 240 V G Y + D++S G+IL+ ++ PFD+ P + + G + + L + Sbjct: 175 VFEGSNY-SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKP 233 Query: 241 VATLLMHMLQVDPLKRATIKDIRE---HEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVC 297 + +L+ DP +R ++++I + H + P P ++ E + V Sbjct: 234 IESLMTRCWSKDPSQRPSMEEIVKIMTH--LMRYFPGADEPLQYPCQHSLPPGEDGR-VE 290 Query: 298 EKFECTESEVMNSLYSGDPQDQLAVAY 324 + E L+S D +Q V Sbjct: 291 PYVDFAEFY---RLWSVDHGEQSVVTA 314 >5NGU-A nrPDB Length = 381 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 124/326 (38%), Gaps = 46/326 (14%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y +G G +G V L +VA+K ++ + REI+ L FRH Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHE 100 Query: 75 HIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 +II + +I PT D ++V + + +L+ + K + QIL + Y Sbjct: 101 NIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKY 158 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG----EFLRTSCGSPNYAAPEVI 185 H V+HRDLKP N+LL+ + KI DFGL+ + FL + Y APE++ Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI------------------- 226 +DIWS G IL +L F +H I Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 227 -RGGVFYIP-----------EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 R + +P + LL ML +P KR ++ H + +Q Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 338 Query: 275 YLFP--EDPSYDANVIDDEAVKEVCE 298 P E P +DD +++ E Sbjct: 339 SDEPIAEAPFKFDMELDDLPKEKLKE 364 >2XNP-A nrPDB Length = 279 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 82/270 (30%), Positives = 132/270 (48%), Gaps = 15/270 (5%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 + Y + T+G G++G+ + + G + K L+ + + + E+ L+ Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE-KQMLVSEVNLLREL 62 Query: 72 RHPHIIKLYQ--VISTPTDFFMVMEYVSGGELFDYICK----HGRVEEMEARRLFQQILS 125 +HP+I++ Y + T T ++VMEY GG+L I K ++E R+ Q+ Sbjct: 63 KHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122 Query: 126 AVDYCHR-----HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNY 179 A+ CHR H V+HRDLKP NV LD N K+ DFGL+ +++ D F +T G+P Y Sbjct: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYY 182 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF-YIPEYLN 238 +PE R+ + DIWS G +LY L PF L KIR G F IP + Sbjct: 183 MSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYS 241 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + ++ ML + R ++++I E+ Sbjct: 242 DELNEIITRMLNLKDYHRPSVEEILENPLI 271 >3LM0-A nrPDB Length = 327 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 88/286 (30%), Positives = 138/286 (48%), Gaps = 14/286 (4%) Query: 16 YVL-GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 Y+L LG G F V+ + TG + A K L +++ R D +I EI L+L + Sbjct: 30 YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILHEIAVLELAKSC 88 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVDYCH 131 P +I L++V ++ +++EY +GGE+F V E + RL +QIL V Y H Sbjct: 89 PRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLH 148 Query: 132 RHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 ++ +VH DLKP+N+LL + + KI DFG+S + LR G+P Y APE+++ Sbjct: 149 QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYD 208 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY----LNRSVATL 244 D+W+ G+I Y LL T PF E + I E +++ Sbjct: 209 P-ITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDF 267 Query: 245 LMHMLQVDPLKRATIKDIREHEWFKQ-DLPSYLFPEDPSYDANVID 289 + +L +P KR T + H W +Q D + PE+ S + D Sbjct: 268 IQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQD 313 >4CRS-A nrPDB Length = 341 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 86/302 (28%), Positives = 141/302 (46%), Gaps = 13/302 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN-- 67 + + + L G FGKV + E++ T A+K L + I + D V + E + Sbjct: 8 QFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE 67 Query: 68 -LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 + RHP ++ L+ T VMEY +GG+L +I E A ++ Sbjct: 68 TVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLG 126 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNM-MSDGEFLRTSCGSPNYAAPEVI 185 + Y H H +V+RDLK +N+LLD KIADFGL M G+ T CG+P + APEV+ Sbjct: 127 LQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLL 245 + Y VD W GV++Y +L G PF + +F I P +L+ +++ Sbjct: 187 TETSYT-RAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIM 245 Query: 246 MHMLQVDPLKRA-----TIKDIREHEWFKQDLPSYLFPE--DPSYDANVIDDEAVKEVCE 298 +L+ +P +R +D+++H +F+ S L + P + + E V + Sbjct: 246 RRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 305 Query: 299 KF 300 +F Sbjct: 306 EF 307 >6GQK-A nrPDB Length = 328 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 105/287 (36%), Gaps = 31/287 (10%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ-----LTGHKVAVKILNRQKIRSLDVVGKI 61 H G TLG G FGKV Q VAVK+L + + Sbjct: 34 HKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHST--EREAL 91 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH------------ 108 E++ L H +I+ L + ++ EY G+L +++ + Sbjct: 92 MSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPE 151 Query: 109 ----GRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 + Q+ + + +HRDL N+LL KI DFGL+ + Sbjct: 152 DLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDI 211 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 + + + APE I +Y E D+WS G+ L+ L G+ P+ V Sbjct: 212 KNDSNYVDKGNARLPVKWMAPESIFNSVYTF-ESDVWSYGIFLWELFSLGSSPYPGMPVD 270 Query: 221 -TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 +K I+ G PEY + ++ DP KR T K I + Sbjct: 271 SKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >3A4O-X nrPDB Length = 286 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 126/289 (43%), Gaps = 20/289 (6%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 K + L LG G FG+V +G + + KVAVK L + V E Sbjct: 4 DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS----VQAFLEE 58 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQ 122 +K +H +++LY V++ +++ EY++ G L D++ + G+V + Q Sbjct: 59 ANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQ 118 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYA 180 I + Y R +HRDL+ NVL+ + KIADFGL+ ++ D E+ R P + Sbjct: 119 IAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWT 178 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYIP--EYL 237 APE I+ + + D+WS G++LY ++ G +P+ + + G + +P E Sbjct: 179 APEAINFGCFT-IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQG-YRMPRVENC 236 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286 + ++ + +R T + + L + + Y Sbjct: 237 PDELYDIMKMCWKEKAEERPTFD------YLQSVLDDFYTATEGQYQQQ 279 >4QTB-A nrPDB Length = 380 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 128/327 (39%), Gaps = 48/327 (14%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y +G G +G V + +VA+K ++ + REIQ L FRH Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHE 99 Query: 75 HIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 ++I + ++ T D ++V + + +L+ + ++ QIL + Y Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKSQ-QLSNDHICYFLYQILRGLKY 157 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN----MMSDGEFLRTSCGSPNYAAPEVI 185 H V+HRDLKP N+L++ + KI DFGL+ FL + Y APE++ Sbjct: 158 IHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIM 217 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY------------- 232 +DIWS G IL +L F +H I G + Sbjct: 218 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMK 277 Query: 233 -------------------IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLP 273 P+ ++++ LL ML +P KR T+++ H + +Q Sbjct: 278 ARNYLQSLPSKTKVAWAKLFPKSDSKAL-DLLDRMLTFNPNKRITVEEALAHPYLEQYYD 336 Query: 274 SYLFP--EDPSYDANVIDDEAVKEVCE 298 P E+P A +DD + + E Sbjct: 337 PTDEPVAEEPFTFAMELDDLPKERLKE 363 >3BGP-A nrPDB Length = 333 Score = 247 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 78/266 (29%), Positives = 127/266 (47%), Gaps = 14/266 (5%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR---EIQNLKL 70 Y +G LG G FG V G VA+K + + +I + R E+ LK Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 71 FRHPH--IIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAV 127 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 175 Query: 128 DYCHRHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 +CH V+HRD+K EN+L+D K+ DFG ++ D + G+ Y+ PE I Sbjct: 176 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIR 234 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G +WS G++LY ++CG +PF+ + ++I G + + ++ L+ Sbjct: 235 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 288 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 L + P R T ++I+ H W + L Sbjct: 289 WCLALRPSDRPTFEEIQNHPWMQDVL 314 >5O2C-A nrPDB Length = 380 Score = 247 bits (632), Expect = 8e-66, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 138/308 (44%), Gaps = 32/308 (10%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G F V G T +VA L +K+ + + K E + LK +HP+I++ Y Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFY 90 Query: 81 QVIST----PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH--M 134 + +V E ++ G L Y+ + ++ R +QIL + + H Sbjct: 91 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 135 VVHRDLKPENVLLDAH-MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGP 193 ++HRDLK +N+ + + KI D GL+ +M F ++ G+P + APE+ + Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMR-TSFAKSVIGTPEFMAPEM--YEEHYDE 207 Query: 194 EVDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGVFY--IPEYLNRSVATLLMHMLQ 250 VD+++ G+ + + P+ + ++ +++K+ G+ + + V ++ ++ Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIR 267 Query: 251 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 + +R +I+D+ H +F +D + E+ E+ +C+ S + Sbjct: 268 QNKSERLSIRDLLNHAFFAEDTGLRV------------------ELAEEDDCSNSSLALR 309 Query: 311 LYSGDPQD 318 L+ DP+ Sbjct: 310 LWVEDPKK 317 >1K9A-A nrPDB Length = 450 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 120/261 (45%), Gaps = 15/261 (5%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 + + L T+G G FG V +G+++ G+KVAVK + + E + Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK-----NDATAQAFLAEASVM 240 Query: 69 KLFRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILS 125 RH ++++L VI ++V EY++ G L DY+ GR + + + Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 A++Y + VHRDL NVL+ AK++DFGL+ S + T + APE + Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEAL 358 Query: 186 SGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVAT 243 + ++ + D+WS G++L+ + G +P+ + + ++ G P+ +V Sbjct: 359 REKKFST-KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 Query: 244 LLMHMLQVDPLKRATIKDIRE 264 ++ + +D R T +RE Sbjct: 418 VMKNCWHLDAATRPTFLQLRE 438 >3DLS-A nrPDB Length = 335 Score = 247 bits (631), Expect = 9e-66, Method: Composition-based stats. Identities = 82/278 (29%), Positives = 137/278 (49%), Gaps = 14/278 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVG-----KIKREIQNLK 69 Y LG G FG V + +V VK + ++K+ + K+ EI L Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGG-ELFDYICKHGRVEEMEARRLFQQILSAVD 128 H +IIK+ + F +VME G +LF +I +H R++E A +F+Q++SAV Sbjct: 85 RVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVG 144 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 188 Y ++HRD+K EN+++ K+ DFG + + G+ T CG+ Y APEV+ G Sbjct: 145 YLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGN 204 Query: 189 LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248 Y GPE+++WS GV LY L+ PF + ++ + P +++ + +L+ + Sbjct: 205 PYRGPELEMWSLGVTLYTLVFEENPFCE------LEETVEAAIHPPYLVSKELMSLVSGL 258 Query: 249 LQVDPLKRATIKDIREHEWFKQ--DLPSYLFPEDPSYD 284 LQ P +R T++ + W Q +L Y + E + Sbjct: 259 LQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVN 296 >4RC3-A nrPDB Length = 289 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 78/266 (29%), Positives = 127/266 (47%), Gaps = 14/266 (5%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR---EIQNLKL 70 Y +G LG G FG V G VA+K + + +I + R E+ LK Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 71 FRHPH--IIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAV 127 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 131 Query: 128 DYCHRHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 +CH V+HRD+K EN+L+D K+ DFG ++ D + G+ Y+ PE I Sbjct: 132 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIR 190 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G +WS G++LY ++CG +PF+ + ++I G + + ++ L+ Sbjct: 191 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 244 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 L + P R T ++I+ H W + L Sbjct: 245 WCLALRPSDRPTFEEIQNHPWMQDVL 270 >6CQF-A nrPDB Length = 297 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 118/269 (43%), Gaps = 11/269 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R HY L LG GT+G+V +++G VA+K++ K+ D V +++EI LK Sbjct: 12 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMV---KMEPDDDVSTLQKEILILK 68 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 RH +I+ + ++ ME+ G L D G + E++ + +++L + Y Sbjct: 69 TCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAY 128 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNYAAPEV--IS 186 H +HRD+K N+L++ ++ADFG+S + R G+P + APEV ++ Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-----LNRSV 241 + DIWS G+ L P D H + + + P + + Sbjct: 189 LKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAF 248 Query: 242 ATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + L P KR + + H+ Q Sbjct: 249 HNFIKVTLTKSPKKRPSATKMLSHQLVSQ 277 >3C51-A nrPDB Length = 543 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 74/265 (27%), Positives = 125/265 (47%), Gaps = 15/265 (5%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 LG G FG+V + + TG A K LN+++++ E + L I+ L Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSL 250 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYI----CKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 T TD +VM ++GG++ +I + +E A QI+S +++ H+ + Sbjct: 251 AYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNI 310 Query: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSPNYAAPEVISGRLYAGPE 194 ++RDLKPENVLLD N +I+D GL+ + G+ + G+P + APE++ G Y Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEY-DFS 369 Query: 195 VDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ 250 VD ++ GV LY ++ PF + L +++ P+ + + +LQ Sbjct: 370 VDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQ 429 Query: 251 VDPLKRATIKD-----IREHEWFKQ 270 DP KR +D +R H F+ Sbjct: 430 KDPEKRLGFRDGSCDGLRTHPLFRD 454 >4AN9-A nrPDB Length = 301 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 67/265 (25%), Positives = 122/265 (46%), Gaps = 7/265 (2%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G +K + LG G G V H+ +G +A K+++ + + +I RE+Q L Sbjct: 4 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVL 61 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 P+I+ Y + + + ME++ GG L + K GR+ E ++ ++ + Sbjct: 62 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 129 YC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Y +H ++HRD+KP N+L+++ K+ DFG+S + D E G+ +Y +PE + G Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPERLQG 180 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-IPE-YLNRSVATLL 245 + + DIWS G+ L + G P + L I +P + + Sbjct: 181 T-HYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFV 239 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQ 270 L +P +RA +K + H + K+ Sbjct: 240 NKCLIKNPAERADLKQLMVHAFIKR 264 >2HK5-A nrPDB Length = 270 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 123/265 (46%), Gaps = 13/265 (4%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 +K + L LG G FG+V + + KVAVK + + V E Sbjct: 6 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS----VEAFLAE 60 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQ 122 +K +H ++KL+ V+ T +++ E+++ G L D++ + + + Q Sbjct: 61 ANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 119 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYA 180 I + + + +HRDL+ N+L+ A + KIADFGL+ ++ D E+ R P + Sbjct: 120 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWT 179 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLN 238 APE I+ + + D+WS G++L ++ G +P+ P + + + RG PE Sbjct: 180 APEAINFGSFT-IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 238 Query: 239 RSVATLLMHMLQVDPLKRATIKDIR 263 + ++M + P +R T + I+ Sbjct: 239 EELYNIMMRCWKNRPEERPTFEYIQ 263 >3FI2-A nrPDB Length = 353 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 80/346 (23%), Positives = 124/346 (35%), Gaps = 64/346 (18%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVN 81 Query: 73 HPHIIKLYQVISTPT------DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 H +II L V + D ++VME + L I ++ L Q+L Sbjct: 82 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCG 138 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 198 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV---------------- 230 G Y VDIWS G I+ ++ + F + K+ + Sbjct: 199 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 257 Query: 231 -----------FYIPEYLNRS---------------VATLLMHMLQVDPLKRATIKDIRE 264 P+ S LL ML +DP KR ++ D + Sbjct: 258 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 317 Query: 265 HEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 310 H + + Y DE + E E EVMNS Sbjct: 318 HPYI-----------NVWYXXXXXXDEREHTIEEWKELIYKEVMNS 352 >1BYG-A nrPDB Length = 278 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 64/261 (24%), Positives = 120/261 (45%), Gaps = 15/261 (5%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 + + L T+G G FG V +G+++ G+KVAVK + + E + Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK-----NDATAQAFLAEASVM 68 Query: 69 KLFRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILS 125 RH ++++L VI ++V EY++ G L DY+ GR + + + Sbjct: 69 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 128 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 A++Y + VHRDL NVL+ AK++DFGL+ S + T + APE + Sbjct: 129 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEAL 186 Query: 186 SGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVAT 243 + ++ + D+WS G++L+ + G +P+ + + ++ G P+ +V Sbjct: 187 REKKFST-KSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 245 Query: 244 LLMHMLQVDPLKRATIKDIRE 264 ++ + +D R + +RE Sbjct: 246 VMKNCWHLDAAMRPSFLQLRE 266 >1FVR-A nrPDB Length = 327 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 112/273 (41%), Gaps = 28/273 (10%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKV--AVKILNRQKIRSLDVVGKIKREIQNL-KL 70 D +G G FG+V + G ++ A+K + + S D E++ L KL Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK--EYASKDDHRDFAGELEVLCKL 82 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------------RVEEM 114 HP+II L ++ +EY G L D++ K + Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 115 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 174 + + +DY + +HRDL N+L+ + AKIADFGLS +++ + Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR--GQEVYVKKTM 200 Query: 175 GSP--NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGV 230 G + A E ++ +Y D+WS GV+L+ ++ G P+ L++K+ +G Sbjct: 201 GRLPVRWMAIESLNYSVYTT-NSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 259 Query: 231 FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 P + V L+ + P +R + I Sbjct: 260 LEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >2PSQ-A nrPDB Length = 370 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 119/286 (41%), Gaps = 32/286 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGE----HQLTGHK---VAVKILNRQKIRSLDVVGKI 61 LG LG G FG+V + E + + VAVK+L + + Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK--DLSDL 133 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ +K+ +H +II L + ++++EY S G L +Y+ Sbjct: 134 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 193 Query: 110 -----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 ++ + Q+ ++Y +HRDL NVL+ + KIADFGL+ + Sbjct: 194 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 253 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 ++ ++ + + + APE + R+Y + D+WS GV+++ + G P+ V Sbjct: 254 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTH-QSDVWSFGVLMWEIFTLGGSPYPGIPVE 312 Query: 221 TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LFK ++ G P + ++ P +R T K + E Sbjct: 313 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >5L6P-A nrPDB Length = 298 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 113/267 (42%), Gaps = 15/267 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + + + + +G G FG+V G + G + VA+K L + E Sbjct: 15 EIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVG--YTERQRRDFLSEAS 72 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F HP+II+L V++ ++ E++ L ++ + G+ ++ + + I + Sbjct: 73 IMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAA 132 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD---GEFLRTSCGSP---NY 179 + Y VHRDL N+L+++++ K++DFGLS + D +S G + Sbjct: 133 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW 192 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYL 237 APE I+ R + D+WS G++++ ++ G P+ D + + P Sbjct: 193 TAPEAIAYRKFTSA-SDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDC 251 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIRE 264 ++ L++ D R I Sbjct: 252 PTALHQLMLDCWVRDRNLRPKFSQIVN 278 >3QGY-A nrPDB Length = 286 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 61/260 (23%), Positives = 112/260 (43%), Gaps = 13/260 (5%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 + +G G FG V +G L KVA+K + + D E + + Sbjct: 24 IDPSELTFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIKEGSMSEDD----FIEEAEVMMK 78 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSAVDY 129 HP +++LY V +V E++ G L DY+ + G + + + Y Sbjct: 79 LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAY 138 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPEVIS 186 V+HRDL N L+ + K++DFG++ + D ++ +S G+ +A+PEV S Sbjct: 139 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQY-TSSTGTKFPVKWASPEVFS 197 Query: 187 GRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATL 244 Y+ + D+WS GV+++ + G +P+++ + + I G Y P + V + Sbjct: 198 FSRYSS-KSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQI 256 Query: 245 LMHMLQVDPLKRATIKDIRE 264 + H + P R + Sbjct: 257 MNHCWKERPEDRPAFSRLLR 276 >1G3N-A nrPDB Length = 326 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 83/315 (26%), Positives = 126/315 (40%), Gaps = 42/315 (13%) Query: 15 HYVLGDTLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR- 72 Y +G G +GKV + G VA+K + Q + I RE+ L+ Sbjct: 12 QYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTI-REVAVLRHLET 70 Query: 73 --HPHIIKLYQVIS-----TPTDFFMVMEYVSGGELFDYICK--HGRVEEMEARRLFQQI 123 HP++++L+ V + T +V E+V +L Y+ K V + + Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 L +D+ H H VVHRDLKP+N+L+ + K+ADFGL+ + S L + + Y APE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG-----GVFYIPEYL- 237 V+ YA P VD+WS G I + F KI G P + Sbjct: 190 VLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 238 -------NRSV--------------ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276 ++S LL+ L +P KR + H +F QDL Sbjct: 249 LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-QDLERCK 307 Query: 277 FPEDPSYDANVIDDE 291 D + E Sbjct: 308 ENLDSHLPPSQNTSE 322 >6E4F-A nrPDB Length = 290 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 61/262 (23%), Positives = 118/262 (45%), Gaps = 13/262 (4%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + LG G FG VK G+ + + VA+K++ + + E + Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE----FIEEAKV 79 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSA 126 + H +++LY V + F++ EY++ G L +Y+ + R + + + + + A Sbjct: 80 MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 139 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y +HRDL N L++ K++DFGLS + D E+ +S GS ++ PE Sbjct: 140 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEY-TSSVGSKFPVRWSPPE 198 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSV 241 V+ ++ + DIW+ GV+++ + G +P++ + I G Y P + V Sbjct: 199 VLMYSKFSS-KSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKV 257 Query: 242 ATLLMHMLQVDPLKRATIKDIR 263 T++ +R T K + Sbjct: 258 YTIMYSCWHEKADERPTFKILL 279 >5TUR-A nrPDB Length = 404 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 78/266 (29%), Positives = 127/266 (47%), Gaps = 14/266 (5%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR---EIQNLKL 70 Y +G LG G FG V G VA+K + + +I + R E+ LK Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 71 FRHPH--IIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAV 127 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 246 Query: 128 DYCHRHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 +CH V+HRD+K EN+L+D K+ DFG ++ D + G+ Y+ PE I Sbjct: 247 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIR 305 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 246 Y G +WS G++LY ++CG +PF+ + ++I G + + ++ L+ Sbjct: 306 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 359 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 L + P R T ++I+ H W + L Sbjct: 360 WCLALRPSDRPTFEEIQNHPWMQDVL 385 >1U5R-A nrPDB Length = 348 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 113/264 (42%), Gaps = 9/264 (3%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 +G G+FG V VA+K ++ +S + I +E++ L+ RHP+ I+ Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVH 137 ++VMEY G D + H + ++E+E + L + Y H H ++H Sbjct: 119 YRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIH 177 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI--SGRLYAGPEV 195 RD+K N+LL K+ DFG +++M+ + G+P + APEVI +V Sbjct: 178 RDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEGQYDGKV 234 Query: 196 DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY--IPEYLNRSVATLLMHMLQVDP 253 D+WS G+ L P + + + I + + + LQ P Sbjct: 235 DVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIP 294 Query: 254 LKRATIKDIREHEWFKQDLPSYLF 277 R T + + +H + ++ P + Sbjct: 295 QDRPTSEVLLKHRFVLRERPPTVI 318 >2VWV-A nrPDB Length = 302 Score = 245 bits (626), Expect = 4e-65, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 115/266 (43%), Gaps = 15/266 (5%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRSLDVVGKIKREIQ 66 + + + + + +G G FG+V G + G K VA+K L + + E Sbjct: 12 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK--GGYTERQRREFLSEAS 69 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILS 125 + F HP+II+L V++ ++ E++ G L ++ + G+ ++ + + I S Sbjct: 70 IMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIAS 129 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP------NY 179 + Y VHRDL N+L+++++ K++DFGLS + + T S + Sbjct: 130 GMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW 189 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GVFYIPEYL 237 APE I+ R + D WS G++++ ++ G P+ D + I P Sbjct: 190 TAPEAIAFRKFTSA-SDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDC 248 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIR 263 S+ L++ Q D R + Sbjct: 249 PTSLHQLMLDCWQKDRNARPRFPQVV 274 >6E2O-A nrPDB Length = 295 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 117/269 (43%), Gaps = 17/269 (6%) Query: 15 HYVLGD-----TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 Y + LG GT+G V G ++A+K + + R + + EI K Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHE---EIALHK 74 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVE--EMEARRLFQQILSA 126 +H +I++ S + ME V GG L + K G ++ E +QIL Sbjct: 75 HLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEG 134 Query: 127 VDYCHRHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSD-GEFLRTSCGSPNYAAPEV 184 + Y H + +VHRD+K +NVL++ KI+DFG S ++ T G+ Y APE+ Sbjct: 135 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEI 194 Query: 185 I-SGRLYAGPEVDIWSCGVILYALLCGTLPFD--DEHVPTLFKK-IRGGVFYIPEYLNRS 240 I G G DIWS G + + G PF E +FK + IPE ++ Sbjct: 195 IDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAE 254 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFK 269 ++ + DP KRA D+ E+ K Sbjct: 255 AKAFILKCFEPDPDKRACANDLLVDEFLK 283 >2GCD-A nrPDB Length = 309 Score = 244 bits (624), Expect = 6e-65, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 113/264 (42%), Gaps = 9/264 (3%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 +G G+FG V VA+K ++ +S + I +E++ L+ RHP+ I+ Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHMVVH 137 ++VMEY G D + H + ++E+E + L + Y H H ++H Sbjct: 80 YRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIH 138 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI--SGRLYAGPEV 195 RD+K N+LL K+ DFG +++M+ + G+P + APEVI +V Sbjct: 139 RDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEGQYDGKV 195 Query: 196 DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY--IPEYLNRSVATLLMHMLQVDP 253 D+WS G+ L P + + + I + + + LQ P Sbjct: 196 DVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIP 255 Query: 254 LKRATIKDIREHEWFKQDLPSYLF 277 R T + + +H + ++ P + Sbjct: 256 QDRPTSEVLLKHRFVLRERPPTVI 279 >4PDO-A nrPDB Length = 299 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 68/255 (26%), Positives = 115/255 (45%), Gaps = 14/255 (5%) Query: 20 DTLGVGTFGKVKIGEHQ-LTGHK---VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 +G G FG+V G + +G K VA+K L V E + F H + Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV--DFLGEAGIMGQFSHHN 97 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYCHRHM 134 II+L VIS ++ EY+ G L ++ + G ++ + + I + + Y Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN 157 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG--EFLRTSCG--SPNYAAPEVISGRLY 190 VHRDL N+L+++++ K++DFGLS ++ D TS G + APE IS R + Sbjct: 158 YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF 217 Query: 191 AGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLLMHM 248 D+WS G++++ ++ G P+ + + K I G P ++ L+M Sbjct: 218 TSA-SDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQC 276 Query: 249 LQVDPLKRATIKDIR 263 Q + +R DI Sbjct: 277 WQQERARRPKFADIV 291 >5Z33-A nrPDB Length = 425 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 81/326 (24%), Positives = 126/326 (38%), Gaps = 50/326 (15%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 + Y + LG G +G V + T VA+K + + + REI+ L+ Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVT-NVFSKKILAKRALREIKLLQH 86 Query: 71 FR-HPHIIKLYQV-ISTPTDF---FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 FR H +I LY + I P +F ++ E + +L I + + + QIL Sbjct: 87 FRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAHFQSFIYQILC 145 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-----DGEFLRTSCGSPNYA 180 + Y H V+HRDLKP N+L++A KI DFGL+ S + ++ + Y Sbjct: 146 GLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYR 205 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI-------------- 226 APE++ +D+WS G IL LL G F +I Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSR 265 Query: 227 ------RGGVFYIP-----------EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF- 268 + V +P N LL ML DP R +++ EH + Sbjct: 266 IGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLH 325 Query: 269 ----KQDLPSYLFPEDPSYDANVIDD 290 D P P ++D V++D Sbjct: 326 IWHDASDEPDC--PTTFNFDFEVVED 349 >5G6V-A nrPDB Length = 324 Score = 244 bits (623), Expect = 8e-65, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 123/288 (42%), Gaps = 35/288 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + Y+ D LG GT+ V G+ +LT + VA+K + + RE+ LK + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPC--TAIREVSLLKDLK 58 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME-ARRLFQQILSAVDYCH 131 H +I+ L+ +I T +V EY+ +L Y+ G + M + Q+L + YCH Sbjct: 59 HANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 117 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVISGRLY 190 R V+HRDLKP+N+L++ K+ADFGL+ S + + Y P+++ G Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI-------------------RGGVF 231 ++D+W G I Y + G F V I + Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 232 YIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 P+Y L+ A LL +LQ + R + +D +H +F Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4H1J-A nrPDB Length = 293 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 68/261 (26%), Positives = 110/261 (42%), Gaps = 12/261 (4%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGE---HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + VL LG G FG+V G H+ VAVK + +LD K E Sbjct: 21 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKD--CTLDNKEKFMSEAVI 78 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSA 126 +K HPHI+KL +I +++ME GEL Y+ ++ ++ + QI A Sbjct: 79 MKNLDHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKA 137 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP--NYAAPEV 184 + Y VHRD+ N+L+ + K+ DFGLS + D ++ + S + +PE Sbjct: 138 MAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPES 197 Query: 185 ISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVA 242 I+ R + D+W V ++ +L G PF + + G P+ + Sbjct: 198 INFRRFTTA-SDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLY 256 Query: 243 TLLMHMLQVDPLKRATIKDIR 263 TL+ DP R ++ Sbjct: 257 TLMTRCWDYDPSDRPRFTELV 277 >4K33-A nrPDB Length = 325 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 117/286 (40%), Gaps = 32/286 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK-------VAVKILNRQKIRSLDVVGKI 61 + LG LG G FG+V + E VAVK+L + + + Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA--TDKDLSDL 88 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ +K+ +H +II L + ++++EY + G L +++ Sbjct: 89 VSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTS 148 Query: 110 -----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 ++ + Q+ ++Y +HRDL NVL+ KIADFGL+ + Sbjct: 149 KPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV 208 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 + ++ + + + APE + R+Y + D+WS GV+L+ + G P+ V Sbjct: 209 HNLDYYKETTNGRLPVKWMAPEALFDRVYTH-QSDVWSFGVLLWEIFTLGGSPYPGIPVE 267 Query: 221 TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LFK ++ G P + ++ P +R T K + E Sbjct: 268 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >4BGQ-A nrPDB Length = 304 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 68/291 (23%), Positives = 121/291 (41%), Gaps = 36/291 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + + +G G +G V H+ T VA+K + + +V RE++ L+ + Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF-KDSEENEEVKETTLRELKMLRTLK 69 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 +I++L + ++V EYV L V + + Q++ A+ +CH+ Sbjct: 70 QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 129 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--LRTSCGSPNYAAPEVISGRLY 190 + +VHRD+KPEN+L+ + K+ DFG + +S+G + Y +PE++ G Y Sbjct: 130 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPY 189 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-------------- 236 G VD+WS G IL L G F E I+ + +P Sbjct: 190 -GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 248 Query: 237 ------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 LN + L+ ++L++DP R + H F+ Sbjct: 249 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >1UA2-A nrPDB Length = 346 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 113/296 (38%), Gaps = 35/296 (11%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV--VGKIKREI 65 D + + Y D LG G F V + T VA+K + REI Sbjct: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQIL 124 + L+ HP+II L ++ +V +++ +L I + + + L Sbjct: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTL 122 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSPNYAAPE 183 ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ S + Y APE Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGGVFYI-----PEYL 237 ++ G G VD+W+ G IL LL +PF + +I + P+ Sbjct: 183 LLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 Query: 238 N-----------------------RSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + + L+ + +P R T + ++F Sbjct: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >4XLV-A nrPDB Length = 328 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 114/301 (37%), Gaps = 25/301 (8%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIG--EHQLTGH---KVAVKILNRQKIRSLDVVGK 60 + V L LG G+FG V G + G +VAVK +N SL + Sbjct: 31 PDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA--SLRERIE 88 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK----------HGR 110 E +K F H+++L V+S +VME ++ G+L Y+ Sbjct: 89 FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPP 148 Query: 111 VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL 170 E ++ +I + Y + VHRDL N ++ KI DFG++ + + ++ Sbjct: 149 PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY 208 Query: 171 RTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI 226 R + APE + ++ D+WS GV+L+ + P+ + K + Sbjct: 209 RKGGKGLLPVRWMAPESLKDGVFTT-SSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 267 Query: 227 R-GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDA 285 GG P+ V L+ Q +P R T +I K DL + Sbjct: 268 MDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVN--LLKDDLHPSFPEVSFFHSE 325 Query: 286 N 286 Sbjct: 326 E 326 >4U41-A nrPDB Length = 332 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 80/325 (24%), Positives = 134/325 (41%), Gaps = 42/325 (12%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R G + L + +G GT+G+V G H TG A+K+++ + D +IK EI LK Sbjct: 20 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV----TEDEEEEIKLEINMLK 75 Query: 70 LF-RHPHIIKLYQVI------STPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLF 120 + H +I Y ++VME+ G + D + K ++E + Sbjct: 76 KYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYIS 135 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-TSCGSPNY 179 ++IL + + H H V+HRD+K +NVLL + K+ DFG+S + R T G+P + Sbjct: 136 REILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 195 Query: 180 AAPEVISGRLY----AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE 235 APEVI+ D+WSCG+ + G P D H F IP Sbjct: 196 MAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL-------FLIPR 248 Query: 236 YLNRSV---------ATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286 + + + L + ++R + + + +H + + P + Sbjct: 249 NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQ------PNERQVRIQ 302 Query: 287 VID--DEAVKEVCEKFECTESEVMN 309 + D D K+ EK E + Sbjct: 303 LKDHIDRTRKKRGEKDETEYEYSGS 327 >5AMN-A nrPDB Length = 299 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 117/274 (42%), Gaps = 23/274 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEH-QLTGH----KVAVKILNRQKIRSLDVVGKIKR 63 + VLG TLG G FGKV L G VAVK+L S + + Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLS 75 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----------VEE 113 E LK HPH+IKLY S +++EY G L ++ + + + Sbjct: 76 EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTM 135 Query: 114 MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLRT 172 + QI + Y +VHRDL N+L+ KI+DFGLS + + +++ Sbjct: 136 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 195 Query: 173 SCG--SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG 229 S G + A E + +Y + D+WS GV+L+ ++ G P+ LF ++ G Sbjct: 196 SQGRIPVKWMAIESLFDHIYTT-QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTG 254 Query: 230 -VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 P+ + + L++ + +P KR DI Sbjct: 255 HRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 288 >5EG3-A nrPDB Length = 334 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 118/286 (41%), Gaps = 32/286 (11%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGE----HQLTGHK---VAVKILNRQKIRSLDVVGKI 61 LG LG G FG+V + E + + VAVK+L + + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK--DLSDL 87 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ +K+ +H +II L + ++++ Y S G L +Y+ Sbjct: 88 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDIN 147 Query: 110 -----RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM 164 ++ + Q+ ++Y +HRDL NVL+ + KIADFGL+ + Sbjct: 148 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 207 Query: 165 SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVP 220 ++ +F + + + APE + R+Y + D+WS GV+++ + G P+ V Sbjct: 208 NNIDFFKETTNGRLPVKWMAPEALFDRVYTH-QSDVWSFGVLMWEIFTLGGSPYPGIPVE 266 Query: 221 TLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LFK ++ G P + ++ P +R T K + E Sbjct: 267 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4XI2-A nrPDB Length = 446 Score = 242 bits (617), Expect = 4e-64, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 118/262 (45%), Gaps = 13/262 (4%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + LG G FG VK G+ + + VA+K++ + + E + Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMSEDE----FIEEAKV 235 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSA 126 + H +++LY V + F++ EY++ G L +Y+ + R + + + + + A Sbjct: 236 MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 295 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y +HRDL N L++ K++DFGLS + D E+ +S GS ++ PE Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEY-TSSVGSKFPVRWSPPE 354 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSV 241 V+ ++ + DIW+ GV+++ + G +P++ + I G Y P + V Sbjct: 355 VLMYSKFSS-KSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERV 413 Query: 242 ATLLMHMLQVDPLKRATIKDIR 263 T++ +R + K + Sbjct: 414 YTIMYSCWHEKADERPSFKILL 435 >3KUL-B nrPDB Length = 325 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 121/276 (43%), Gaps = 18/276 (6%) Query: 3 EKQKHDGR-----VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHK---VAVKILNRQKIRS 54 E+ GR ++ + +G G G+V G ++ G + VA+K L + Sbjct: 33 EEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK--AGYT 90 Query: 55 LDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEE 113 E + F HP+II+L V++ +V EY+ G L ++ H G+ Sbjct: 91 ERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTI 150 Query: 114 MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRT 172 M+ + + + + + Y VHRDL NVL+D+++ K++DFGLS ++ D + T Sbjct: 151 MQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYT 210 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYA-LLCGTLPFDDEHVPTLFKKIRG 228 + G + APE I+ R ++ D+WS GV+++ L G P+ + + + Sbjct: 211 TTGGKIPIRWTAPEAIAFRTFSSA-SDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEE 269 Query: 229 G-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 G P ++ L++ D +R I Sbjct: 270 GYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIV 305 >5O2B-A nrPDB Length = 285 Score = 241 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 60/261 (22%), Positives = 123/261 (47%), Gaps = 14/261 (5%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 LG G F V G T +VA L +K+ + + K E + LK +HP+I++ Y Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-QRFKEEAEMLKGLQHPNIVRFY 81 Query: 81 QVIST----PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH--M 134 + +V E ++ G L Y+ + ++ R +QIL + + H Sbjct: 82 DSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 135 VVHRDLKPENVLLDAH-MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGP 193 ++HRDLK +N+ + + KI D GL+ +M F ++ G+P + APE+ + Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMR-TSFAKSVIGTPEFMAPEM--YEEHYDE 198 Query: 194 EVDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGVFY--IPEYLNRSVATLLMHMLQ 250 VD+++ G+ + + P+ + ++ +++K+ G+ + + V ++ ++ Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIR 258 Query: 251 VDPLKRATIKDIREHEWFKQD 271 + +R +I+D+ H +F +D Sbjct: 259 QNKSERLSIRDLLNHAFFAED 279 >4EQM-A nrPDB Length = 294 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 80/289 (27%), Positives = 140/289 (48%), Gaps = 15/289 (5%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G++ Y + D LG G V + E + KVA+K + + + + +RE+ N Sbjct: 6 GKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNS 65 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 H +I+ + V +++VMEY+ G L +YI HG + A QIL + Sbjct: 66 SQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIK 125 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC--GSPNYAAPEVIS 186 + H +VHRD+KP+N+L+D++ KI DFG++ +S+ +T+ G+ Y +PE Sbjct: 126 HAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAK 185 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL-FKKIRGGVF----YIPEYLNRSV 241 G DI+S G++LY +L G PF+ E ++ K I+ V + + + +S+ Sbjct: 186 GEA-TDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSL 244 Query: 242 ATLLMHMLQVDPLKRA-TIKDIREHEWFKQDLPSYLFPEDPSYDANVID 289 + +++ + D R TI++ K DL S L + D +D Sbjct: 245 SNVILRATEKDKANRYKTIQE------MKDDLSSVLHENRANEDVYELD 287 >4HZS-A nrPDB Length = 341 Score = 241 bits (615), Expect = 7e-64, Method: Composition-based stats. Identities = 68/256 (26%), Positives = 102/256 (39%), Gaps = 13/256 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQ-LTGHKV--AVKILNRQKIRSLDVVGKIKREIQNLKLF 71 L + LG G+FG V+ GE +G V AVK L + + + RE+ + Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYC 130 H ++I+LY V+ TP MV E G L D + KH G R Q+ + Y Sbjct: 73 DHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 131 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----YAAPEVIS 186 +HRDL N+LL KI DFGL + + + APE + Sbjct: 132 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 191 Query: 187 GRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVAT 243 R ++ D W GV L+ + G P+ + + KI G PE + + Sbjct: 192 TRTFSHA-SDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 250 Query: 244 LLMHMLQVDPLKRATI 259 +++ P R T Sbjct: 251 VMVQCWAHKPEDRPTF 266 >3BEA-A nrPDB Length = 333 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 112/280 (40%), Gaps = 29/280 (10%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKR 63 + G TLG G FGKV G KVAVK+L D + Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH--ADEKEALMS 98 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE--------- 113 E++ + +H +I+ L + ++ EY G+L +++ + RV E Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIAN 158 Query: 114 -----MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 168 + Q+ + + +HRD+ NVLL AKI DFGL+ + + Sbjct: 159 STLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDS 218 Query: 169 FLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFK 224 + + APE I +Y + D+WS G++L+ + G P+ V + F Sbjct: 219 NYIVKGNARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFY 277 Query: 225 KIR--GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 K+ G P + +++ +++ ++P R T + I Sbjct: 278 KLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >6FEX-A nrPDB Length = 321 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 108/304 (35%), Gaps = 47/304 (15%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGE----------------HQLTGHKVAVKILNRQKIR 53 + LG G FG+V + E + VAVKIL + Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 71 Query: 54 SLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG---- 109 + +E++ + + P+II+L V M+ +Y+ G+L ++ H Sbjct: 72 N--ARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDK 129 Query: 110 ---------RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160 + + QI S + Y VHRDL N L+ + KIADFG+ Sbjct: 130 AAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 189 Query: 161 SNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYA--LLCGTLPFD 215 S + G++ R + + A E I + D+W+ GV L+ +LC PF Sbjct: 190 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTA-SDVWAFGVTLWEVLMLCRAQPFG 248 Query: 216 DEHVPTLFKKI--------RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEW 267 + + R P + + L++ + +R + H + Sbjct: 249 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--HRF 306 Query: 268 FKQD 271 +D Sbjct: 307 LAED 310 >4LQP-A nrPDB Length = 508 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 70/351 (19%), Positives = 131/351 (37%), Gaps = 72/351 (20%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + +G G FG+V++ + + TG A+K L + ++ D + +K E L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 P ++ LY +++ME++ GG+L + + E R + + A++ H+ Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSN------------------------------- 162 +HR +KP+N+L+D + K++DFGLS Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYN 281 Query: 163 --------------------MMSDGEFLRTSCGSPNYAA-----------PEVISGRLYA 191 MS+ + ++T S A PE+ + Y Sbjct: 282 ANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGY- 340 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG--GVFYIPE--YLNRSVATLLMH 247 G E D WS G I+Y L G PF E ++KI P+ +++ L+ Sbjct: 341 GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRR 400 Query: 248 MLQVDPLKRA----TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVK 294 +L +R +I+ H +F+ + + + Y + + Sbjct: 401 LLTH-ADQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTR 450 >2OGV-A nrPDB Length = 317 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 111/276 (40%), Gaps = 25/276 (9%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKR 63 + G TLG G FGKV G KVAVK+L D + Sbjct: 33 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH--ADEKEALMS 90 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH----------GRVE 112 E++ + +H +I+ L + ++ EY G+L +++ + +E Sbjct: 91 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLE 150 Query: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT 172 + Q+ + + +HRD+ NVLL AKI DFGL+ + + Sbjct: 151 LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIV 210 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR- 227 + + APE I +Y + D+WS G++L+ + G P+ V + F K+ Sbjct: 211 KGNARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 269 Query: 228 -GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G P + +++ +++ ++P R T + I Sbjct: 270 DGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >4Y93-A nrPDB Length = 446 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 58/262 (22%), Positives = 117/262 (44%), Gaps = 13/262 (4%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + LG G FG VK G+ + + VA+K++ + + E + Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE----FIEEAKV 236 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSA 126 + H +++LY V + F++ EY++ G L +Y+ + R + + + + + A Sbjct: 237 MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 296 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAPE 183 ++Y +HRDL N L++ K++DFG++ + D E+ +S GS +A+PE Sbjct: 297 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEY-TSSTGSKFPVKWASPE 355 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSV 241 V+ ++ + DIW+ GV+++ + G +P++ + I G P + V Sbjct: 356 VLMYSKFSS-KSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERV 414 Query: 242 ATLLMHMLQVDPLKRATIKDIR 263 ++ +R T K + Sbjct: 415 YAIMYSCWHEKADERPTFKILL 436 >5U6B-A nrPDB Length = 307 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 131/302 (43%), Gaps = 27/302 (8%) Query: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH--KVAVKILNRQKIRSLDVVGK 60 +++ D V LG TLG G FG V G+ KVAVK + + I + + Sbjct: 12 KEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELED 70 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDF------FMVMEYVSGGELFDYIC------KH 108 E +K F HP++++L V ++ +++ ++ G+L ++ + Sbjct: 71 FLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQP 130 Query: 109 GRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 168 + + I S ++Y +HRDL N +L+ +M+ +ADFGLS + +G+ Sbjct: 131 VYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGD 190 Query: 169 FLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFK 224 + R + + A E ++ R+Y + D+WS GV ++ + G P+ ++ Sbjct: 191 YYRQGRIAKMPVKWIAIESLADRVYTS-KSDVWSFGVTMWEIATRGQTPYPGVENSEIYD 249 Query: 225 KIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 283 +R G P + L+ +++P R + ++RE DL + L P+ Sbjct: 250 YLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRE------DLENTLKALPPAQ 303 Query: 284 DA 285 + Sbjct: 304 EP 305 >1U54-B nrPDB Length = 291 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 104/260 (40%), Gaps = 13/260 (5%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQ-LTGHKV--AVKILNRQKIRSLDVVGKIKREIQNLKLF 71 L + LG G+FG V+ GE +G V AVK L + + + RE+ + Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 78 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQILSAVDYC 130 H ++I+LY V+ TP MV E G L D + KH G R Q+ + Y Sbjct: 79 DHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYL 137 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----YAAPEVIS 186 +HRDL N+LL KI DFGL + + + APE + Sbjct: 138 ESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLK 197 Query: 187 GRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI--RGGVFYIPEYLNRSVAT 243 R ++ D W GV L+ + G P+ + + KI G PE + + Sbjct: 198 TRTFSHA-SDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYN 256 Query: 244 LLMHMLQVDPLKRATIKDIR 263 +++ P R T +R Sbjct: 257 VMVQCWAHKPEDRPTFVALR 276 >3QUP-A nrPDB Length = 323 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 118/290 (40%), Gaps = 29/290 (10%) Query: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTG---HKVAVKILNRQKIRSLDVVG 59 +++ D + + LG LG G FG V+ + + KVAVK+L I S D + Sbjct: 12 KEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD-IE 70 Query: 60 KIKREIQNLKLFRHPHIIKLYQVISTPTDF------FMVMEYVSGGELFDYICKHG---- 109 + RE +K F HPH+ KL V +++ ++ G+L ++ Sbjct: 71 EFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGEN 130 Query: 110 --RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG 167 + R I ++Y +HRDL N +L M +ADFGLS + G Sbjct: 131 PFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG 190 Query: 168 EFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF 223 ++ R C S + A E ++ LY D+W+ GV ++ ++ G P+ ++ Sbjct: 191 DYYRQGCASKLPVKWLALESLADNLYT-VHSDVWAFGVTMWEIMTRGQTPYAGIENAEIY 249 Query: 224 KKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATI-------KDIREH 265 + GG P V L+ DP +R + ++I H Sbjct: 250 NYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >4YHJ-A nrPDB Length = 584 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 77/354 (21%), Positives = 142/354 (40%), Gaps = 30/354 (8%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 + HY LG G FG+V + + TG A K L +++I+ E + L+ Sbjct: 184 KNTFRHY---RVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 127 + ++ L T +V+ ++GG+L +I G +E A ++ + Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 + R +V+RDLKPEN+LLD + +I+D GL+ + +G+ +R G+ Y APEV++ Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHV----PTLFKKIRGGVFYIPEYLNRSVAT 243 Y D W G ++Y ++ G PF + ++I+ E + + Sbjct: 361 EKYTF-SPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419 Query: 244 LLMHMLQVDPLKRA-----TIKDIREHEWFKQD----------LPSYLFPEDPSYDANVI 288 + +L +P KR +++H FK P + Y +V+ Sbjct: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVL 479 Query: 289 DDEAVK-----EVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQA 337 D E + E + S Q+++ + N+ +A Sbjct: 480 DIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEA 533 >3MIA-A nrPDB Length = 351 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 131/314 (41%), Gaps = 53/314 (16%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 ++ Y +G GTFG+V H+ TG KVA+K + + REI+ L+L Sbjct: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-LMENEKEGFPITALREIKILQLL 73 Query: 72 RHPHIIKLYQVISTP--------TDFFMVMEYVSG---GELFDYICKHGRVEEMEARRLF 120 +H +++ L ++ T ++V ++ G L + + K E +R+ Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVM 130 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-----SDGEFLRTSCG 175 Q +L+ + Y HR+ ++HRD+K NVL+ K+ADFGL+ S Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Query: 176 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL----------------------P 213 + Y PE++ G GP +D+W G I+ + + P Sbjct: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 Query: 214 --FDDEHVPTLFKK---IRGGVFYIPEYL-----NRSVATLLMHMLQVDPLKRATIKDIR 263 + + L++K ++G + + L + L+ +L +DP +R D Sbjct: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 Query: 264 EHEWFKQDL-PSYL 276 H++F D PS L Sbjct: 311 NHDFFWSDPMPSDL 324 >1AD5-A nrPDB Length = 438 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 122/286 (42%), Gaps = 25/286 (8%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 +K + L LG G FG+V + + KVAVK + + V E Sbjct: 173 EKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS----VEAFLAE 227 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQ 122 +K +H ++KL+ V+ T +++ E+++ G L D++ + + + Q Sbjct: 228 ANVMKTLQHDKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 286 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAP 182 I + + + +HRDL+ N+L+ A + KIADFGL+ + + + AP Sbjct: 287 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAKFPIKWTAP 338 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRS 240 E I+ + + D+WS G++L ++ G +P+ P + + + RG PE Sbjct: 339 EAINFGSFT-IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEE 397 Query: 241 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286 + ++M + P +R T + + + L + + Y Sbjct: 398 LYNIMMRCWKNRPEERPTFE------YIQSVLDDFYTATESQYQQQ 437 >3KRL-A nrPDB Length = 335 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 111/282 (39%), Gaps = 31/282 (10%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKR 63 + G TLG G FGKV G KVAVK+L D + Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH--ADEKEALMS 98 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG------------- 109 E++ + +H +I+ L + ++ EY G+L +++ + Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHN 158 Query: 110 ---RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 166 ++ + Q+ + + +HRD+ NVLL AKI DFGL+ + + Sbjct: 159 PEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 218 Query: 167 GEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTL 222 + + APE I +Y + D+WS G++L+ + G P+ V + Sbjct: 219 DSNYIVKGNARLPVKWMAPESIFDCVYT-VQSDVWSYGILLWEIFSLGLNPYPGILVNSK 277 Query: 223 FKKIR--GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 F K+ G P + +++ +++ ++P R T + I Sbjct: 278 FYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >4XUF-A nrPDB Length = 297 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 107/289 (37%), Gaps = 38/289 (13%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEH---QLTGH--KVAVKILNRQKIRSLDVVGKIKR 63 + G LG G FGKV TG +VAVK+L + S + Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS--EREALMS 61 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARR--- 118 E++ + H +I+ L + +++ EY G+L +Y+ K + E E Sbjct: 62 ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQ 121 Query: 119 -------------------LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG 159 Q+ +++ VHRDL NVL+ KI DFG Sbjct: 122 KRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG 181 Query: 160 LSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFD 215 L+ + + + APE + +Y + D+WS G++L+ + G P+ Sbjct: 182 LARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYT-IKSDVWSYGILLWEIFSLGVNPYP 240 Query: 216 DEHVPTLFKKIRGGVFYI--PEYLNRSVATLLMHMLQVDPLKRATIKDI 262 V F K+ F + P Y + ++ D KR + ++ Sbjct: 241 GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >6BSD-A nrPDB Length = 876 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 108/310 (34%), Gaps = 53/310 (17%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGE----------------HQLTGHKVAVKILNRQKIR 53 + LG G FG+V + E + VAVKIL + Sbjct: 567 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626 Query: 54 SLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG---- 109 + +E++ + + P+II+L V M+ +Y+ G+L ++ H Sbjct: 627 N--ARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDK 684 Query: 110 ---------------RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK 154 + + QI S + Y VHRDL N L+ + K Sbjct: 685 AAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744 Query: 155 IADFGLSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYA--LLC 209 IADFG+S + G++ R + + A E I + D+W+ GV L+ +LC Sbjct: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTA-SDVWAFGVTLWEVLMLC 803 Query: 210 GTLPFDDEHVPTLFKKI--------RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKD 261 PF + + R P + + L++ + +R Sbjct: 804 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 863 Query: 262 IREHEWFKQD 271 + H + +D Sbjct: 864 L--HRFLAED 871 >4PWN-A nrPDB Length = 274 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 129/277 (46%), Gaps = 14/277 (5%) Query: 6 KHDGRVKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 K G G ++ D +G G+F V G T +VA L +K+ + + K E Sbjct: 1 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSE-RQRFKEE 59 Query: 65 IQNLKLFRHPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + LK +HP+I++ Y + +V E ++ G L Y+ + ++ R Sbjct: 60 AEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWC 119 Query: 121 QQILSAVDYCHRH--MVVHRDLKPENVLLDAH-MNAKIADFGLSNMMSDGEFLRTSCGSP 177 +QIL + + H ++HRDLK +N+ + + KI D GL+ + F ++ G+P Sbjct: 120 RQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTP 179 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDD-EHVPTLFKKIRGGVFY--IP 234 + APE+ + VD+++ G+ + + P+ + ++ +++++ GV Sbjct: 180 EFMAPEMYEEK--YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFD 237 Query: 235 EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 + V ++ ++ + +R +IKD+ H +F+++ Sbjct: 238 KVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE 274 >3GC0-A nrPDB Length = 329 Score = 237 bits (606), Expect = 7e-63, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 120/295 (40%), Gaps = 38/295 (12%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 I Y LG GT+G+V +T VA+K + + V G RE+ LK + Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH-EEEGVPGTAIREVSLLKELQ 91 Query: 73 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 H +II+L VI ++ EY +L Y+ K+ V + Q+++ V++CH Sbjct: 92 HRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHS 150 Query: 133 HMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVIS 186 +HRDLKP+N+LL KI DFGL+ + Y PE++ Sbjct: 151 RRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILL 210 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG----------------- 229 G + VDIWS I +L T F + KI Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 230 -VFYIPEYLNRSVATLL------------MHMLQVDPLKRATIKDIREHEWFKQD 271 P++ +++ +L ML++DP+KR + K+ EH +F + Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHN 325 >3G0E-A nrPDB Length = 336 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 108/288 (37%), Gaps = 33/288 (11%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIG-----EHQLTGHKVAVKILNRQKIRSLDVVGKI 61 H G TLG G FGKV VAVK+L L + Sbjct: 39 HKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH--LTEREAL 96 Query: 62 KREIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----------- 109 E++ L H +I+ L + ++ EY G+L +++ + Sbjct: 97 MSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPA 156 Query: 110 -------RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN 162 ++ + Q+ + + +HRDL N+LL KI DFGL+ Sbjct: 157 IMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR 216 Query: 163 MMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEH 218 + + + + APE I +Y E D+WS G+ L+ L G+ P+ Sbjct: 217 DIKNDSNYVVKGNARLPVKWMAPESIFNCVYTF-ESDVWSYGIFLWELFSLGSSPYPGMP 275 Query: 219 VPTLFKKIRGGVFYI--PEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 V + F K+ F + PE+ + ++ DPLKR T K I + Sbjct: 276 VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >1LUF-A nrPDB Length = 343 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 109/284 (38%), Gaps = 41/284 (14%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTG-------HKVAVKILNRQKIRSLDVVGKIKRE 64 + +G G FG+V G VAVK+L + S D+ +RE Sbjct: 45 PRNNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEA--SADMQADFQRE 100 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK----------HGRVEEM 114 + F +P+I+KL V + ++ EY++ G+L +++ H + Sbjct: 101 AALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTR 160 Query: 115 --------------EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160 E + +Q+ + + Y VHRDL N L+ +M KIADFGL Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGL 220 Query: 161 SNMMSDGEFLR---TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDD 216 S + ++ + + PE I Y E D+W+ GV+L+ + G P+ Sbjct: 221 SRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTT-ESDVWAYGVVLWEIFSYGLQPYYG 279 Query: 217 EHVPTLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATI 259 + +R G + PE + L+ P R + Sbjct: 280 MAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSF 323 >5HLW-A nrPDB Length = 299 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 108/258 (41%), Gaps = 15/258 (5%) Query: 18 LGDTLGVGTFGKVKIGEH-QLTGHKV--AVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 + +G G FG V G G K+ AVK LNR I + V + E +K F HP Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHP 81 Query: 75 HIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHR 132 +++ L + + +V+ Y+ G+L ++I + Q+ + Y Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS 141 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS-----PNYAAPEVISG 187 VHRDL N +LD K+ADFGL+ M D E+ + + A E + Sbjct: 142 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQT 201 Query: 188 RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLL 245 + + + D+WS GV+L+ L+ G P+ D + + + G PEY + ++ Sbjct: 202 QKFTT-KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 260 Query: 246 MHMLQVDPLKRATIKDIR 263 + R + ++ Sbjct: 261 LKCWHPKAEMRPSFSELV 278 >3PP0-A nrPDB Length = 338 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 127/317 (40%), Gaps = 25/317 (7%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGH----KVAVKILNRQKIRSLDVVGKIKREIQ 66 +K LG G FG V G G VA+K+L S +I E Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENT--SPKANKEILDEAY 71 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILS 125 + P++ +L + T T +V + + G L D++ + GR+ + QI Sbjct: 72 VMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAP 182 + Y +VHRDL NVL+ + + KI DFGL+ ++ E + G + A Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMAL 190 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRS 240 E I R + + D+WS GV ++ L+ G P+D + + G P Sbjct: 191 ESILRRRFTH-QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTID 249 Query: 241 VATLLMHMLQVDPLKRATIKDIR-EHEWFKQDLPSYLF----------PEDPSYDANVID 289 V +++ +D R +++ E +D ++ P D ++ ++++ Sbjct: 250 VYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLE 309 Query: 290 DEAVKEVCEKFECTESE 306 D+ + ++ + E + Sbjct: 310 DDDMGDLVDAEEYLVPQ 326 >5X02-A nrPDB Length = 347 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 107/289 (37%), Gaps = 38/289 (13%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEH---QLTGH--KVAVKILNRQKIRSLDVVGKIKR 63 + G LG G FGKV TG +VAVK+L + S + Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS--EREALMS 100 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARR--- 118 E++ + H +I+ L + +++ EY G+L +Y+ K + E E Sbjct: 101 ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQ 160 Query: 119 -------------------LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG 159 Q+ +++ VHRDL NVL+ KI DFG Sbjct: 161 KRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG 220 Query: 160 LSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFD 215 L+ + + + APE + +Y + D+WS G++L+ + G P+ Sbjct: 221 LARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYT-IKSDVWSYGILLWEIFSLGVNPYP 279 Query: 216 DEHVPTLFKKIRGGVFYI--PEYLNRSVATLLMHMLQVDPLKRATIKDI 262 V F K+ F + P Y + ++ D KR + ++ Sbjct: 280 GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >3M42-A nrPDB Length = 299 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 88/318 (27%), Positives = 140/318 (44%), Gaps = 57/318 (17%) Query: 13 IGHYVL-GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL-KL 70 I Y + LG+G GKV ++ T K A+K+L K +RE++ + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRA 67 Query: 71 FRHPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQIL 124 + PHI+++ V +VME + GGELF I G E EA + + I Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 A+ Y H + HRD+KPEN+L + + K+ DFG + + + Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEK------------- 174 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE-- 235 D+WS GVI+Y LLCG PF H P + +IR G + P Sbjct: 175 ---------YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 225 Query: 236 --YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAV 293 ++ V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ Sbjct: 226 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL----- 277 Query: 294 KEVCEKFECTESEVMNSL 311 KE E++E + E+ ++L Sbjct: 278 KEDKERWEDVKEEMTSAL 295 >3LZB-A nrPDB Length = 327 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 70/278 (25%), Positives = 114/278 (41%), Gaps = 15/278 (5%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKV----AVKILNRQKIRSLDVVGKIKREIQ 66 +K + LG G FG V G G KV A+K L ++ S +I E Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL--REATSPKANKEILDEAY 69 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILS 125 + +PH+ +L + T T ++ + + G L DY+ +H + QI Sbjct: 70 VMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 128 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAP 182 ++Y +VHRDL NVL+ + KI DFGL+ ++ E + G + A Sbjct: 129 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 188 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRS 240 E I R+Y + D+WS GV ++ L+ G+ P+D + + G P Sbjct: 189 ESILHRIYTH-QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 247 Query: 241 VATLLMHMLQVDPLKRATIKD-IREHEWFKQDLPSYLF 277 V ++ +D R ++ I E +D YL Sbjct: 248 VYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLV 285 >5GNK-A nrPDB Length = 297 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 71/278 (25%), Positives = 116/278 (41%), Gaps = 15/278 (5%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKV----AVKILNRQKIRSLDVVGKIKREIQ 66 +K + LG G FG V G G KV A+K L ++ S +I E Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL--REATSPKANKEILDEAY 73 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILS 125 + +PH+ +L + T T ++M+ + G L DY+ +H + QI Sbjct: 74 VMASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NYAAP 182 ++Y +VHRDL NVL+ + KI DFGL+ ++ E + G + A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 192 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRS 240 E I R+Y + D+WS GV ++ L+ G+ P+D + + G P Sbjct: 193 ESILHRIYTH-QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 251 Query: 241 VATLLMHMLQVDPLKRATIKD-IREHEWFKQDLPSYLF 277 V +++ +D R ++ I E +D YL Sbjct: 252 VYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLV 289 >4O2Z-A nrPDB Length = 377 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 109/305 (35%), Gaps = 39/305 (12%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L LG+G +G TG KV++K R R ++ ++ REI ++ F H Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRDVEDGKRVLREIDMMRFFHH 103 Query: 74 PHIIKLYQV-------ISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 126 +++ + + + D ++V + ++ + +EE + QIL Sbjct: 104 ENLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSRQVLEESHMQYFVYQILRG 162 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRTSCGSPNYAAPEVI 185 + Y H V HRDLKP N++ + KI DFGLS + L + Y PE++ Sbjct: 163 LKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELL 222 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG----------------- 228 VDIWS G I + F + + I Sbjct: 223 LENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALE 282 Query: 229 -------GVFYIPEYLN-----RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276 G IP+ + L M +DP KR T D+ H + Sbjct: 283 KLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEED 342 Query: 277 FPEDP 281 P P Sbjct: 343 EPTCP 347 >3CJF-A nrPDB Length = 309 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 112/282 (39%), Gaps = 28/282 (9%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGE-----HQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 LG LG G FG+V + T VAVK+L S + Sbjct: 22 WEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEH--RALMS 79 Query: 64 EIQNLKLFRHP-HIIKLYQVISTPT-DFFMVMEYVSGGELFDYICKHGR----------- 110 E++ L H +++ L + P +++E+ G L Y+ Sbjct: 80 ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKD 139 Query: 111 -VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGE 168 + Q+ +++ +HRDL N+LL KI DFGL+ + D + Sbjct: 140 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 199 Query: 169 FLR--TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF-K 224 ++R + + APE I R+Y + D+WS GV+L+ + G P+ + F + Sbjct: 200 YVRKGDARLPLKWMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCR 258 Query: 225 KIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 +++ G P+Y + ++ +P +R T ++ EH Sbjct: 259 RLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >4R7H-A nrPDB Length = 343 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 112/289 (38%), Gaps = 38/289 (13%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKR 63 + G TLG G FGKV G KVAVK+L D + Sbjct: 45 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH--ADEKEALMS 102 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-------------- 108 E++ + +H +I+ L + ++ EY + G+L +++ + Sbjct: 103 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQD 162 Query: 109 ---------GRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG 159 +E + Q+ + + +HRD+ NVLL AKI DFG Sbjct: 163 PEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG 222 Query: 160 LSNMMSDGEFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFD 215 L+ + + + + APE I +Y + D+WS G++L+ + G P+ Sbjct: 223 LARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYT-VQSDVWSYGILLWEIFSLGLNPYP 281 Query: 216 DEHVPTLFKKIR--GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 V + F K+ G P + +++ +++ ++P R T + I Sbjct: 282 GILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >5FM2-A nrPDB Length = 355 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 117/288 (40%), Gaps = 37/288 (12%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEH-QLTGH----KVAVKILNRQKIRSLDVVGKIKR 63 + VLG TLG G FGKV L G VAVK+L S + + Sbjct: 59 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA--SPSELRDLLS 116 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR------------- 110 E LK HPH+IKLY S +++EY G L ++ + + Sbjct: 117 EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRN 176 Query: 111 -----------VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG 159 + + QI + Y +VHRDL N+L+ KI+DFG Sbjct: 177 SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFG 236 Query: 160 LSN-MMSDGEFLRTSCG--SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFD 215 LS + + +++ S G + A E + +Y + D+WS GV+L+ ++ G P+ Sbjct: 237 LSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT-QSDVWSFGVLLWEIVTLGGNPYP 295 Query: 216 DEHVPTLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 LF ++ G P+ + + L++ + +P KR DI Sbjct: 296 GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >5GRN-A nrPDB Length = 356 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 111/294 (37%), Gaps = 41/294 (13%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-----KVAVKILNRQKIRSLDVVGKIKR 63 VLG LG G FGKV G KVAVK+L S + Sbjct: 41 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK--QALMS 98 Query: 64 EIQNLKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR------------ 110 E++ + H +I+ L + +++ EY G+L +Y+ K+ Sbjct: 99 ELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLD 158 Query: 111 --------------VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIA 156 + ++ Q+ +++ VHRDL NVLL KI Sbjct: 159 SEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKIC 218 Query: 157 DFGLSNMMSDGEFLRTSCGS---PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTL 212 DFGL+ + + + + APE I LY D+WS G++L+ + G Sbjct: 219 DFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTL-SDVWSYGILLWEIFSLGGT 277 Query: 213 PFDDEHVPTLF-KKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 P+ V + F KI+ G P++ V +++ +P KR + + E Sbjct: 278 PYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE 331 >3C1X-A nrPDB Length = 373 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 108/258 (41%), Gaps = 15/258 (5%) Query: 18 LGDTLGVGTFGKVKIGEH-QLTGHKV--AVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 + +G G FG V G G K+ AVK LNR I + V + E +K F HP Sbjct: 93 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR--ITDIGEVSQFLTEGIIMKDFSHP 150 Query: 75 HIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHR 132 +++ L + + +V+ Y+ G+L ++I + Q+ + + Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLAS 210 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS-----PNYAAPEVISG 187 VHRDL N +LD K+ADFGL+ M D EF + + A E + Sbjct: 211 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQT 270 Query: 188 RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLL 245 + + + D+WS GV+L+ L+ G P+ D + + + G PEY + ++ Sbjct: 271 QKFTT-KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 329 Query: 246 MHMLQVDPLKRATIKDIR 263 + R + ++ Sbjct: 330 LKCWHPKAEMRPSFSELV 347 >2W96-B nrPDB Length = 306 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 78/295 (26%), Positives = 121/295 (41%), Gaps = 40/295 (13%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR- 72 Y +GVG +G V +GH VA+K + + + RE+ L+ Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTV-REVALLRRLEA 62 Query: 73 --HPHIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICK--HGRVEEMEARRLFQQI 123 HP++++L V +T +V E+V +L Y+ K + + L +Q Sbjct: 63 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 L +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APE Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPE 181 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY------- 236 V+ YA P VD+WS G I + F KI + PE Sbjct: 182 VLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 240 Query: 237 --------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 271 + S A LL+ ML +P KR + +H + +D Sbjct: 241 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 295 >1TKI-A nrPDB Length = 321 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 65/269 (24%), Positives = 116/269 (43%), Gaps = 12/269 (4%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y++ + LG G FG V + K + + + +K+EI L + RH Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQV----LVKKEISILNIARH 60 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHR 132 +I+ L++ + + M+ E++SG ++F+ I + E E Q+ A+ + H Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHS 120 Query: 133 HMVVHRDLKPENVLLDAHM--NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 H + H D++PEN++ KI +FG + + G+ R +P Y APEV + Sbjct: 121 HNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDV- 179 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----YLNRSVATLLM 246 D+WS G ++Y LL G PF E + + I + E ++ + Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVD 239 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDLPSY 275 +L + R T + +H W KQ + Sbjct: 240 RLLVKERKSRMTASEALQHPWLKQKIERV 268 >3ZBF-A nrPDB Length = 322 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 108/276 (39%), Gaps = 26/276 (9%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQL-----TGH-KVAVKILNRQKIRSLDVVGKIKRE 64 L LG G FG+V G +G KVAVK L + + + +E Sbjct: 30 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKE 87 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE-------EMEAR 117 + F HP+I+K V ++++E + GG+L Y+ K ++ Sbjct: 88 AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV 147 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRT 172 L I Y R +HRDL N L+ + KI DFGL+ + ++ R Sbjct: 148 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 207 Query: 173 SCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR- 227 + APE + ++ + D+WS G++++ +L G P+ + ++ Sbjct: 208 RGEGLLPVRWMAPESLMDGIFTT-QSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 266 Query: 228 GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 GG P + L+ +P +R T I+ Sbjct: 267 GGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQ 302 >3I81-A nrPDB Length = 315 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 113/277 (40%), Gaps = 23/277 (8%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ-----LTGHKVAVKILNRQKIRSLDVVGK 60 + V + LG G+FG V G + +VA+K +N + S+ + Sbjct: 10 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN--EAASMRERIE 67 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE------- 113 E +K F H+++L V+S ++ME ++ G+L Y+ E Sbjct: 68 FLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAP 127 Query: 114 ---MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL 170 + ++ +I + Y + + VHRDL N ++ KI DFG++ + + ++ Sbjct: 128 PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY 187 Query: 171 RTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI 226 R + +PE + ++ D+WS GV+L+ + P+ + + + Sbjct: 188 RKGGKGLLPVRWMSPESLKDGVFTTY-SDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 246 Query: 227 -RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 GG+ P+ + L+ Q +P R + +I Sbjct: 247 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >5KKR-C nrPDB Length = 395 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 128/315 (40%), Gaps = 50/315 (15%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + +KQK G +K + LG G G V H+ +G +A K+++ + + + Sbjct: 56 LTQKQK-VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQ 112 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E ++ Sbjct: 113 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 172 Query: 121 QQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 179 ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y Sbjct: 173 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSY 231 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL----------------- 222 +PE + G + + DIWS G+ L + G P L Sbjct: 232 MSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 290 Query: 223 ----------------------FKKIRGGVFYIPEYLNR-----SVATLLMHMLQVDPLK 255 F+ + V P L + L +P + Sbjct: 291 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAE 350 Query: 256 RATIKDIREHEWFKQ 270 RA +K + H + K+ Sbjct: 351 RADLKQLMVHAFIKR 365 >3EQC-A nrPDB Length = 360 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 128/315 (40%), Gaps = 50/315 (15%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + +KQK G +K + LG G G V H+ +G +A K+++ + + + Sbjct: 21 LTQKQK-VGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQ 77 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I RE+Q L P+I+ Y + + + ME++ GG L + K GR+ E ++ Sbjct: 78 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 137 Query: 121 QQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 179 ++ + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y Sbjct: 138 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSY 196 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL----------------- 222 +PE + G + + DIWS G+ L + G P L Sbjct: 197 MSPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 255 Query: 223 ----------------------FKKIRGGVFYIPEYLNR-----SVATLLMHMLQVDPLK 255 F+ + V P L + L +P + Sbjct: 256 RPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 315 Query: 256 RATIKDIREHEWFKQ 270 RA +K + H + K+ Sbjct: 316 RADLKQLMVHAFIKR 330 >5HIE-A nrPDB Length = 302 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 67/268 (25%), Positives = 121/268 (45%), Gaps = 22/268 (8%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D + G +G +G G+FG V G+ VAVK+L Q++++ K E+ Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQA------FKNEVGV 80 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-HGRVEEMEARRLFQQILSA 126 L+ RH +I+ L+ ST +V ++ G L+ ++ + E ++ + +Q Sbjct: 81 LRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQG 139 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD---GEFLRTSCGSPNYAAPE 183 +DY H ++HRDLK N+ L + KI DFGL+ + S GS + APE Sbjct: 140 MDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 199 Query: 184 VI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE------ 235 VI + + D+++ G++LY L+ G LP+ + + + G + P+ Sbjct: 200 VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRS 259 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIR 263 +++ L+ L+ +R I Sbjct: 260 NCPKAMKRLMAECLKKKRDERPLFPQIL 287 >5HI2-A nrPDB Length = 283 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 66/268 (24%), Positives = 117/268 (43%), Gaps = 22/268 (8%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 D + G +G +G G+FG V G+ VAVK+L Q++++ K E+ Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQA------FKNEVGV 64 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSA 126 L+ RH +I+ L+ ST +V ++ G L+ ++ + E + + +Q Sbjct: 65 LRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARG 123 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD---GEFLRTSCGSPNYAAPE 183 +DY H ++HRDLK N+ L KI DFGL+ + S GS + APE Sbjct: 124 MDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 183 Query: 184 VI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV-PTLFKKIRGGVFYIP-----E 235 VI + D+++ G++LY L+ G LP+ + + + + + G Sbjct: 184 VIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRS 243 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIR 263 + + L+ L+ +R + I Sbjct: 244 NCPKRMKRLMAECLKKKRDERPSFPRIL 271 >6FER-A nrPDB Length = 309 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 64/285 (22%), Positives = 107/285 (37%), Gaps = 42/285 (14%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGH----------------KVAVKILNRQKIRSLDVVGK 60 + LG G FG+V + E + VAVK+L + + Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA--NKNARND 69 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH----------GR 110 +EI+ + + P+II L V T M+ EY+ G+L ++ +H Sbjct: 70 FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRT 129 Query: 111 VEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL 170 V + + QI S + Y VHRDL N L+ + KIADFG+S + G++ Sbjct: 130 VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 189 Query: 171 RTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYA--LLCGTLPFDDEHVPTLFKK 225 R + + + E I + D+W+ GV L+ C P+ + + Sbjct: 190 RIQGRAVLPIRWMSWESILLGKFTTA-SDVWAFGVTLWETFTFCQEQPYSQLSDEQVIEN 248 Query: 226 I--------RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 R P SV L++ + D R + ++I Sbjct: 249 TGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >6DBM-A nrPDB Length = 318 Score = 230 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 81/283 (28%), Positives = 112/283 (39%), Gaps = 32/283 (11%) Query: 19 GDTLGVGTFGKVKIG----EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV + + TG VAVK L K+EI L+ H Sbjct: 36 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADA--GPQHRSGWKQEIDILRTLYHE 93 Query: 75 HIIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HIIK +VMEYV G L DY+ +H + + QQI + Y H Sbjct: 94 HIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEGMAYLHS 152 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTS--CGSP-NYAAPEVISGR 188 +HRDL NVLLD KI DFGL+ + +G E+ R SP + APE + Sbjct: 153 QHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEY 212 Query: 189 LYAGPEVDIWSCGVILYALLCG-----TLP--FDDE----HVPTLFKKI-----RGGVFY 232 + D+WS GV LY LL + P F + ++ RG Sbjct: 213 KFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLP 271 Query: 233 IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSY 275 P+ V L+ + + + R T +++ K Y Sbjct: 272 RPDKCPAEVYHLMKNCWETEASFRPTFENLI--PILKTVHEKY 312 >2W1I-A nrPDB Length = 326 Score = 230 bits (588), Expect = 9e-61, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 126/287 (43%), Gaps = 32/287 (11%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQL----TGHKVAVKILNRQKIRSLDVVG 59 + + + + H LG G FG V++ + TG VAVK L + + + + Sbjct: 31 EDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL---QHSTEEHLR 87 Query: 60 KIKREIQNLKLFRHPHIIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHG-RVEEMEA 116 +REI+ LK +H +I+K V + + ++MEY+ G L DY+ KH R++ ++ Sbjct: 88 DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKL 147 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL---RTS 173 + QI ++Y +HRDL N+L++ KI DFGL+ ++ + + Sbjct: 148 LQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEP 207 Query: 174 CGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-----GTLP--F------DDEHV 219 SP + APE ++ + D+WS GV+LY L + P F D + Sbjct: 208 GESPIFWYAPESLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQ 266 Query: 220 PTLFKKIR----GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 +F I G P+ + ++ + +R + +D+ Sbjct: 267 MIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >3IO7-A nrPDB Length = 313 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 70/276 (25%), Positives = 122/276 (44%), Gaps = 32/276 (11%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQL----TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 H LG G FG V++ + TG VAVK L + + + + +REI+ LK Sbjct: 29 HLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL---QHSTEEHLRDFEREIEILKS 85 Query: 71 FRHPHIIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAV 127 +H +I+K V + + ++MEY+ G L DY+ KH R++ ++ + QI + Sbjct: 86 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 145 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL---RTSCGSP-NYAAPE 183 +Y +HRDL N+L++ KI DFGL+ ++ + + SP + APE Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 205 Query: 184 VISGRLYAGPEVDIWSCGVILYALLC-----GTLP--F------DDEHVPTLFKKIR--- 227 ++ + D+WS GV+LY L + P F D + +F I Sbjct: 206 SLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK 264 Query: 228 -GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 G P+ + ++ + +R + +D+ Sbjct: 265 NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >4LRM-A nrPDB Length = 334 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 130/321 (40%), Gaps = 29/321 (9%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKV----AVKILNRQKIRSLDVVGKIKREIQ 66 +K + LG G FG V G G KV A+K L ++ S +I E Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL--REATSPKANKEILDEAY 73 Query: 67 NLKLFRHP---HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQ 122 + +P H+ +L + T T ++ + + G L DY+ +H + Q Sbjct: 74 VMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---NY 179 I ++Y +VHRDL NVL+ + KI DFGL+ ++ E + G + Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYL 237 A E I R+Y + D+WS GV ++ L+ G+ P+D + + G P Sbjct: 193 MALESILHRIYTH-QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 251 Query: 238 NRSVATLLMHMLQVDPLKRATIKD-IREHEWFKQDLPSYLF-----------PEDPSYDA 285 V +++ +D R ++ I E +D YL P D ++ Sbjct: 252 TIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYR 311 Query: 286 NVIDDEAVKEVCEKFECTESE 306 ++D+E + +V + E + Sbjct: 312 ALMDEEDMDDVVDADEYLIPQ 332 >3ORP-A nrPDB Length = 311 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 126/296 (42%), Gaps = 21/296 (7%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y LG+ LG G +V + VAVK+L R + +RE QN H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 74 PHIIKLYQVISTPTDF----FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 P I+ +Y T ++VMEYV G L D + G + A + A+++ Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNF 131 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS----CGSPNYAAPEVI 185 H++ ++HRD+KP N+++ A K+ DFG++ ++D T G+ Y +PE Sbjct: 132 SHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQA 191 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL-FKKIRGGVFYIP---EYLNRSV 241 G D++S G +LY +L G PF + ++ ++ +R E L+ + Sbjct: 192 RGDS-VDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADL 250 Query: 242 ATLLMHMLQVDPLKRA-TIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEV 296 +++ L +P R T + + DL + +P V+ D + Sbjct: 251 DAVVLKALAKNPENRYQTAAE------MRADLVR-VHNGEPPEAPKVLTDAERTSL 299 >4OLI-A nrPDB Length = 645 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 80/283 (28%), Positives = 113/283 (39%), Gaps = 32/283 (11%) Query: 19 GDTLGVGTFGKVKIG----EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV + + TG VAVK L K+EI L+ H Sbjct: 358 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD--CGPQHRSGWKQEIDILRTLYHE 415 Query: 75 HIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HIIK + +VMEYV G L DY+ +H + + QQI + Y H Sbjct: 416 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQICEGMAYLHS 474 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTS--CGSP-NYAAPEVISGR 188 +HR+L NVLLD KI DFGL+ + +G E+ R SP + APE + Sbjct: 475 QHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEY 534 Query: 189 LYAGPEVDIWSCGVILYALLCG-----TLP--FDDE----HVPTLFKKI-----RGGVFY 232 + D+WS GV LY LL + P F + ++ RG Sbjct: 535 KFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLP 593 Query: 233 IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSY 275 P+ V L+ + + + R T +++ K Y Sbjct: 594 RPDKCPCEVYHLMKNCWETEASFRPTFENLI--PILKTVHEKY 634 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 109/303 (35%), Gaps = 27/303 (8%) Query: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMV 92 G + +V +K+L+ D+ + H H+ ++ V + MV Sbjct: 88 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 144 Query: 93 MEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL---- 147 EYV G L ++ + G V + QQ+ SA+ Y +VH ++ N+LL Sbjct: 145 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 204 Query: 148 ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-GPEVDIWSCGVI 203 K++D G+ E + APE + G + +D W G Sbjct: 205 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 261 Query: 204 LYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 L + G P + +PE +ATL L +P +R + + I Sbjct: 262 LLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTI 320 Query: 263 REHEWFKQDLPSYLF------PEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDP 316 + P L P+ P+ D V +K++ + E +V SLY DP Sbjct: 321 LRD--LTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKV--SLYCYDP 376 Query: 317 QDQ 319 + Sbjct: 377 TND 379 >6DBN-A nrPDB Length = 316 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 114/277 (41%), Gaps = 38/277 (13%) Query: 19 GDTLGVGTFGKVKIGEHQL----TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV++ + TG +VAVK L + + + +K+EI+ L+ H Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADLKKEIEILRNLYHE 97 Query: 75 HIIKLYQVISTP--TDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCH 131 +I+K + + ++ME++ G L +Y+ K+ ++ + + QI +DY Sbjct: 98 NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLG 157 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP----NYAAPEVISG 187 VHRDL NVL+++ KI DFGL+ + + T + APE + Sbjct: 158 SRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQ 217 Query: 188 RLYAGPEVDIWSCGVILYALLCGTLPFDDEH--VPTLFKKI------------------R 227 + D+WS GV L+ LL + D LF K+ Sbjct: 218 SKFY-IASDVWSFGVTLHELLT----YCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKE 272 Query: 228 GGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 G P V L+ + P R + +++ E Sbjct: 273 GKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >4YFF-A nrPDB Length = 311 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 117/265 (44%), Gaps = 16/265 (6%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 +++ + +G G+FGKV G + VA+K S V RE+ L Sbjct: 38 HLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILC 95 Query: 70 LFRHPHIIKLYQVIS-TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ-QILSAV 127 HP +I+ P+ F +V +Y+SGG LF + + R+ +++++ + + + Sbjct: 96 QLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGM 155 Query: 128 DYCHR--HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSPNYAAPE 183 +Y H ++HRDL N+LL +A +ADFG S + D + + G+ + APE Sbjct: 156 EYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPE 215 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV-----PTLFKKIRGGVFYIPEYLN 238 V + + D++S + L+ +L G +PF + IR I + Sbjct: 216 VFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIR---PPIGYSIP 272 Query: 239 RSVATLLMHMLQVDPLKRATIKDIR 263 + +++LL+ P R ++ Sbjct: 273 KPISSLLIRGWNACPEGRPEFSEVV 297 >1U59-A nrPDB Length = 287 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 67/259 (25%), Positives = 108/259 (41%), Gaps = 14/259 (5%) Query: 11 VKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQN 67 +K + ++ D LG G FG V+ G +++ + VA+K+L + ++ RE Q Sbjct: 6 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQI 63 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSA 126 + +P+I++L V +VME GG L ++ K + L Q+ Sbjct: 64 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 122 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS----PNYAAP 182 + Y VHRDL NVLL AKI+DFGLS + + T+ + + AP Sbjct: 123 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 182 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRS 240 E I+ R ++ D+WS GV ++ L G P+ P + I G P Sbjct: 183 ECINFRKFSS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 241 Query: 241 VATLLMHMLQVDPLKRATI 259 + L+ R Sbjct: 242 LYALMSDCWIYKWEDRPDF 260 >5U6C-A nrPDB Length = 315 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 111/276 (40%), Gaps = 21/276 (7%) Query: 3 EKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQL---TGHKVAVKILNRQKIRSLDVVG 59 + + D + +LG LG G FG V G + T KVAVK + S + Sbjct: 25 QNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDN-SSQREIE 83 Query: 60 KIKREIQNLKLFRHPHIIKLYQVISTP-----TDFFMVMEYVSGGELFDYI------CKH 108 + E +K F HP++++L V +++ ++ G+L Y+ Sbjct: 84 EFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGP 143 Query: 109 GRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 168 + + I ++Y +HRDL N +L M +ADFGLS + G+ Sbjct: 144 KHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGD 203 Query: 169 FLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFK 224 + R + + A E ++ R+Y + D+W+ GV ++ + G P+ ++ Sbjct: 204 YYRQGRIAKMPVKWIAIESLADRVYTS-KSDVWAFGVTMWEIATRGMTPYPGVQNHEMYD 262 Query: 225 KIR-GGVFYIPEYLNRSVATLLMHMLQVDPLKRATI 259 + G PE + ++ + DPL R T Sbjct: 263 YLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTF 298 >1ZXE-A nrPDB Length = 303 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 118/289 (40%), Gaps = 41/289 (14%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + LG G FG+V + L A+K + + + + I E+ L H Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR----HTEEKLSTILSEVMLLASLNH 61 Query: 74 PHIIKLYQVIST-------------PTDFFMVMEYVSGGELFDYICKHGRVEE-MEARRL 119 ++++ Y + F+ MEY L+D I ++ E RL Sbjct: 62 QYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRL 121 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-------------- 165 F+QIL A+ Y H ++HR+LKP N+ +D N KI DFGL+ + Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 166 -DGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLF 223 + L ++ G+ Y A EV+ G + ++D++S G+I + ++ PF + Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNIL 238 Query: 224 KKIRGGVFYIPEYLNRSV----ATLLMHMLQVDPLKRATIKDIREHEWF 268 KK+R P + + ++ ++ DP KR + + W Sbjct: 239 KKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >4E20-A nrPDB Length = 290 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 77/271 (28%), Positives = 111/271 (40%), Gaps = 30/271 (11%) Query: 19 GDTLGVGTFGKVKIG----EHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 LG G FGKV + + TG VAVK L + +REI+ L+ H Sbjct: 13 IRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEG--CGPQLRSGWQREIEILRTLYHE 70 Query: 75 HIIKLYQVISTPTD--FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 HI+K + +VMEYV G L DY+ +H V + QQI + Y H Sbjct: 71 HIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC-VGLAQLLLFAQQICEGMAYLHA 129 Query: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG-EFLRTS--CGSP-NYAAPEVISGR 188 +HR L NVLLD KI DFGL+ + +G E+ R SP + APE + Sbjct: 130 QHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEC 189 Query: 189 LYAGPEVDIWSCGVILYALLC----GTLP---FDD----EHVPTLFKKI-----RGGVFY 232 + D+WS GV LY LL P F + ++ RG Sbjct: 190 KFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGERLP 248 Query: 233 IPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 P+ + L+ + + + R T +++ Sbjct: 249 RPDRCPCEIYHLMKNCWETEASFRPTFQNLV 279 >5HVK-A nrPDB Length = 315 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 70/271 (25%), Positives = 121/271 (44%), Gaps = 27/271 (9%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 G+ LG G FG+ H+ TG + +K L R + +E++ ++ HP+++K Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKELIRF---DEETQRTFLKEVKVMRCLEHPNVLK 75 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHMVVH 137 V+ + EY+ GG L I + + + I S + Y H ++H Sbjct: 76 FIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---------------LRTSCGSPNYAAP 182 R+L N L+ + N +ADFGL+ +M D + T G+P + AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK---KIRG-GVFYIPEYLN 238 E+I+GR Y +VD++S G++L ++ G + D +++P +RG Y P Sbjct: 196 EMINGRSY-DEKVDVFSFGIVLCEII-GRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCP 253 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 S + + +DP KR + EH W + Sbjct: 254 PSFFPITVRCCDLDPEKRPSFVK-LEH-WLE 282 >3PLS-A nrPDB Length = 298 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 65/253 (25%), Positives = 108/253 (42%), Gaps = 15/253 (5%) Query: 20 DTLGVGTFGKVKIGEHQLTGH---KVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 +G G FG V GE+ + A+K L+R I + V RE ++ HP++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 77 IKLYQVISTPTDF-FMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 134 + L ++ P +++ Y+ G+L +I R + Q+ ++Y Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-----RTSCGSPNYAAPEVISGRL 189 VHRDL N +LD K+ADFGL+ + D E+ R + + A E + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 190 YAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLLMH 247 + + D+WS GV+L+ LL G P+ L + G PEY S+ ++ Sbjct: 205 FTT-KSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 263 Query: 248 MLQVDPLKRATIK 260 + DP R T + Sbjct: 264 CWEADPAVRPTFR 276 >3OMV-A nrPDB Length = 307 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 119/269 (44%), Gaps = 17/269 (6%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 + ++ +L +G G+FG V G+ VAVKIL + + + + E+ Sbjct: 29 YYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKIL-KVVDPTPEQFQAFRNEVA 84 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILS 125 L+ RH +I+ L+ T + +V ++ G L+ ++ + + + + + +Q Sbjct: 85 VLRKTRHVNIL-LFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQ 143 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD---GEFLRTSCGSPNYAAP 182 +DY H ++HRD+K N+ L + KI DFGL+ + S + + GS + AP Sbjct: 144 GMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAP 203 Query: 183 EVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE----- 235 EVI + D++S G++LY L+ G LP+ + + G + P+ Sbjct: 204 EVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLY 263 Query: 236 -YLNRSVATLLMHMLQVDPLKRATIKDIR 263 +++ L+ ++ +R I Sbjct: 264 KNCPKAMKRLVADCVKKVKEERPLFPQIL 292 >2OZO-A nrPDB Length = 613 Score = 224 bits (572), Expect = 6e-59, Method: Composition-based stats. Identities = 66/259 (25%), Positives = 108/259 (41%), Gaps = 14/259 (5%) Query: 11 VKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQN 67 +K + ++ D LG G FG V+ G +++ + VA+K+L + ++ RE Q Sbjct: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQI 389 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLFQQILSA 126 + +P+I++L V +VME GG L ++ K + L Q+ Sbjct: 390 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS----PNYAAP 182 + Y VHR+L NVLL AKI+DFGLS + + T+ + + AP Sbjct: 449 MKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 Query: 183 EVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRS 240 E I+ R ++ D+WS GV ++ L G P+ P + I G P Sbjct: 509 ECINFRKFSS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 Query: 241 VATLLMHMLQVDPLKRATI 259 + L+ R Sbjct: 568 LYALMSDCWIYKWEDRPDF 586 >3VN9-A nrPDB Length = 340 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 112/271 (41%), Gaps = 13/271 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 VK LG G +G V+ H +G +AVK + R + S + + +++ Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMR 105 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDY----ICKHGRVEEMEARRLFQQILS 125 P + Y + D ++ ME + L + I K + E ++ I+ Sbjct: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 126 AVDYCHRH-MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 A+++ H V+HRD+KP NVL++A K+ DFG+S + D G Y APE Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 Query: 185 IS---GRLYAGPEVDIWSCGVILYALLCGTLPFD--DEHVPTLFKKIRGGVFYIP-EYLN 238 I+ + + DIWS G+ + L P+D L + + +P + + Sbjct: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 L+ + +R T ++ +H +F Sbjct: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >4NEU-A nrPDB Length = 333 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 132/315 (41%), Gaps = 24/315 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 ++K ++ L G FGKV + H+ G + +K + + ++ + E + + Sbjct: 20 KMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGP-NCIEHNEALLEEAKMMN 77 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129 RH ++KL VI + +VMEY+ G L + R+ +I+ + Y Sbjct: 78 RLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCY 137 Query: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM--------------SDGEFLRTSCG 175 H V+H+DLKPEN+L+D + KIAD GL++ + + G Sbjct: 138 LHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGG 197 Query: 176 SPNYAAPEVISG-RLYAGPEVDIWSCGVILYALLCGTLPFDDEH-VPTLFKKIRGGVFY- 232 + Y APE ++ + D++S V+L+A+ P+++ L I+ G Sbjct: 198 TLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPD 257 Query: 233 ---IPEYLNRSVATLLMHMLQVDPLKRATIKDIRE--HEWFKQDLPSYLFPEDPSYDANV 287 I EY R + +L+ + +P R T I E ++ L + + S Sbjct: 258 VDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEY 317 Query: 288 IDDEAVKEVCEKFEC 302 ++ AV + + + Sbjct: 318 SNENAVVKRMQSLQL 332 >3FME-A nrPDB Length = 290 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 112/271 (41%), Gaps = 13/271 (4%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 VK LG G +G V+ H +G +AVK + R + S + + +++ Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMR 61 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDY----ICKHGRVEEMEARRLFQQILS 125 P + Y + D ++ ME + L + I K + E ++ I+ Sbjct: 62 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 126 AVDYCHRH-MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 A+++ H V+HRD+KP NVL++A K+ DFG+S + D G Y APE Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPER 180 Query: 185 IS---GRLYAGPEVDIWSCGVILYALLCGTLPFD--DEHVPTLFKKIRGGVFYIP-EYLN 238 I+ + + DIWS G+ + L P+D L + + +P + + Sbjct: 181 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 240 Query: 239 RSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 L+ + +R T ++ +H +F Sbjct: 241 AEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >5WNO-A nrPDB Length = 330 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 125/296 (42%), Gaps = 22/296 (7%) Query: 17 VLGDTLGVGTFGKVKIGEH-----QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 L LG G FG V G + + VA+K+ + ++ +++ E N+ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLE----EATNMFRL 80 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYC 130 RH +++K+ +V Y G L +++ H + E QI S + Y Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYL 140 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISG 187 + VVHRDL NVL+ + +I DFGLS ++ +D +++ + + A E+ S Sbjct: 141 EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSK 200 Query: 188 RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLL 245 Y D+W+ GV + ++ G P+ ++ ++ G P ++ + L Sbjct: 201 HCYTHA-SDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFE 301 + DP R +I +E FK+ P+ ++N I + + E+F+ Sbjct: 260 LRCWMADPKSRPGF-EIL-YERFKEF---CKVPQLFLENSNKISESDLS-AEERFQ 309 >3AOX-A nrPDB Length = 344 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 119/305 (39%), Gaps = 24/305 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGE-----HQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 V + L LG G FG+V G+ + + +VAVK L ++ S E Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP--EVCSEQDELDFLME 100 Query: 65 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICK-------HGRVEEMEAR 117 + F H +I++ V F+++E ++GG+L ++ + + ++ Sbjct: 101 ALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLL 160 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHM---NAKIADFGLSNMMSDGEFLRTSC 174 + + I Y + +HRD+ N LL AKI DFG++ + + R Sbjct: 161 HVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGG 220 Query: 175 GS---PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIR-GG 229 + + PE ++ + D WS GV+L+ + G +P+ + + + + GG Sbjct: 221 CAMLPVKWMPPEAFMEGIFTS-KTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGG 279 Query: 230 VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH-EWFKQDLPSYLFPEDPSYDANVI 288 P+ V ++ Q P R I E E+ QD Y V Sbjct: 280 RMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVE 339 Query: 289 DDEAV 293 ++E V Sbjct: 340 EEEKV 344 >3N9X-A nrPDB Length = 432 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 80/411 (19%), Positives = 139/411 (33%), Gaps = 94/411 (22%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y++ +G G++G V + + T VA+K +NR L +I REI L + Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRM-FEDLIDCKRILREITILNRLKS 84 Query: 74 PHIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +II+LY +I + ++V+E +L + E + + +L + Sbjct: 85 DYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYNLLLGEN 143 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG--------------------- 167 + H ++HRDLKP N LL+ + K+ DFGL+ ++ Sbjct: 144 FIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKN 203 Query: 168 --EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL----------CGTLP-F 214 + L + + Y APE+I + +DIWS G I LL P F Sbjct: 204 LKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLF 263 Query: 215 DDE-----------------------------------------HVPTLFKKIRGGVFYI 233 + P + K I+ Sbjct: 264 PGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRK 323 Query: 234 P-------EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 286 P ++ LL ML+ +P KR TI +H + K L E+ S Sbjct: 324 PINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKKKL--ENFSTKKI 381 Query: 287 VIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQA 337 ++ + E + + + + I +N N+ Sbjct: 382 ILPFDDW---MVLSETQLRYIFLKEVQSFHPELVIPSVFTIHENNFYNNEK 429 >2I6L-A nrPDB Length = 320 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 116/318 (36%), Gaps = 58/318 (18%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y+ LG G G V +VA+K + + V REI+ ++ H Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDH 67 Query: 74 PHIIKLY--------------QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL 119 +I+K++ ++ ++V EY+ +L + + + G + E AR Sbjct: 68 DNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVL-EQGPLLEEHARLF 125 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDG----EFLRTSC 174 Q+L + Y H V+HRDLKP N+ ++ + KI DFGL+ +M L Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-- 232 + Y +P ++ +D+W+ G I +L G F H + I + Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 245 Query: 233 ----------IP------------------EYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 IP ++R L +L P+ R T ++ Sbjct: 246 EEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALS 305 Query: 265 HEWFKQDLPSYLFPEDPS 282 H + Y FP D Sbjct: 306 HPYMS----IYSFPMDEP 319 >1S9I-A nrPDB Length = 354 Score = 221 bits (563), Expect = 7e-58, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 127/319 (39%), Gaps = 54/319 (16%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + +K K G +K + LG G G V +H+ +G +A K+++ + + + Sbjct: 4 LTQKAK-VGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQ 60 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 I RE+Q L P+I+ Y + + + ME++ GG L + + R+ E ++ Sbjct: 61 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVS 120 Query: 121 QQILSAVDYC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 179 +L + Y +H ++HRD+KP N+L+++ K+ DFG+S + D + G+ +Y Sbjct: 121 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-SMANSFVGTRSY 179 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL----------------- 222 APE + G + + DIWS G+ L L G P L Sbjct: 180 MAPERLQGT-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPH 238 Query: 223 --------------------------FKKIRGGVFYIPEYLN-----RSVATLLMHMLQV 251 F+ + V P L + L Sbjct: 239 SISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIK 298 Query: 252 DPLKRATIKDIREHEWFKQ 270 +P +RA +K + H + K+ Sbjct: 299 NPAERADLKMLTNHTFIKR 317 >3ALO-A nrPDB Length = 327 Score = 220 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 113/282 (40%), Gaps = 15/282 (5%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + + +G G +G V H+ +G +AVK + R + + Sbjct: 9 LKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQL 67 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSG--GELFDYICK--HGRVEEMEA 116 + ++ P+I++ Y + D ++ ME +S + + Y+ + E Sbjct: 68 LMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEIL 127 Query: 117 RRLFQQILSAVDYCHRH-MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG 175 ++ + A+++ + ++HRD+KP N+LLD N K+ DFG+S + D G Sbjct: 128 GKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAG 187 Query: 176 SPNYAAPEVIS---GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV--PTLFKKIRGGV 230 Y APE I R D+WS G+ LY L G P+ + L + ++G Sbjct: 188 CRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDP 247 Query: 231 FYIP----EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + + S + L D KR K++ +H + Sbjct: 248 PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >6GVJ-A nrPDB Length = 429 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 113/272 (41%), Gaps = 22/272 (8%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF--RH 73 Y + +G G KV + A+K +N ++ + + + EI L Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHS 203 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 II+LY T +MVME +L ++ K ++ E + ++ +L AV H+H Sbjct: 204 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLY 190 +VH DLKP N L+ K+ DFG++N M + G+ NY PE I Sbjct: 263 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 191 AGP----------EVDIWSCGVILYALLCGTLPFDD--EHVPTLFKKIR-GGVFYIPEYL 237 + + D+WS G ILY + G PF + L I P+ Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 381 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + + +L L+ DP +R +I ++ H + + Sbjct: 382 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >4TPT-A nrPDB Length = 303 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 30/269 (11%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 G+ LG G FG+ H+ TG + +K L R + E++ ++ HP+++K Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIR---CDEETQKTFLTEVKVMRSLDHPNVLK 61 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 V+ ++ EY+ GG L D++ + R + I S + Y H ++HR Sbjct: 62 FIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMM---------------------SDGEFLRTSCGSP 177 DL N L+ +ADFGLS ++ +D + T G+P Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF----YI 233 + APE+++G+ Y VDI+S G++L ++ G + D + +P ++ Sbjct: 182 YWMAPEMLNGKSY-DETVDIFSFGIVLCEII-GQVYADPDCLPRTLDFGLNVKLFWEKFV 239 Query: 234 PEYLNRSVATLLMHMLQVDPLKRATIKDI 262 P + L +++P R + Sbjct: 240 PTDCPPAFFPLAAICCRLEPESRPAFSKL 268 >4HVI-A nrPDB Length = 314 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 74/272 (27%), Positives = 113/272 (41%), Gaps = 39/272 (14%) Query: 22 LGVGTFGKVKIGEHQL----TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 LG G FG V++ + TG VAVK L + D +REIQ LK I+ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQL---QHSGPDQQRDFQREIQILKALHSDFIV 74 Query: 78 KLYQVISTPTD--FFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRHM 134 K V P +VMEY+ G L D++ +H R++ QI ++Y Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFL--RTSCGSP-NYAAPEVISGRLY 190 VHRDL N+L+++ + KIADFGL+ ++ D ++ R SP + APE +S ++ Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF 194 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIR--------------------GGV 230 + D+WS GV+LY L + D+ + +R G Sbjct: 195 -SRQSDVWSFGVVLYELFT----YCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR 249 Query: 231 FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 P V L+ P R + + Sbjct: 250 LPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >5Y86-A nrPDB Length = 588 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 81/345 (23%), Positives = 128/345 (37%), Gaps = 77/345 (22%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-- 72 Y + +G G+FG+V VA+K++ +K + EI+ L+ + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK----RFHRQAAEEIRILEHLKKQ 263 Query: 73 ----HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSA 126 ++I + + + M E +S +L++ I K+ R+ Q IL + Sbjct: 264 DKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQS 322 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 +D H++ ++H DLKPEN+LL H K+ DFG S + + L T S Y APE+ Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRFYRAPEI 380 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH---------------VPTLFKKIRGG 229 I G Y+ P +DIWS G IL LL G F E P L ++ + Sbjct: 381 ILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 Query: 230 VFY-----IPEYLNRS---------------------------------------VATLL 245 ++ IP Y + + L Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Query: 246 MHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDD 290 L DP R T H W + +P L D V++ Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNP 544 >4OW8-A nrPDB Length = 283 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 69/259 (26%), Positives = 111/259 (42%), Gaps = 9/259 (3%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 G G Y L + G G+V G +VAVK+L + + + + + E Sbjct: 3 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEA 62 Query: 66 QNLKLFRHPHIIKLYQVIS-----TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + + HP I ++ ++VME V+G L + + GR+ A + Sbjct: 63 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDML 122 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT--SCGSPN 178 +Q A+ H +VHRD+KP N+L+ KI DFG++ + +T G+ Sbjct: 123 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 182 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL-FKKIRGGVFYIPEYL 237 Y APE G A P D++S GV+ Y + G PF + T+ K I+ +P L Sbjct: 183 YIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDL 241 Query: 238 NRSVATLLMHMLQVDPLKR 256 +V L+ L +P R Sbjct: 242 PPNVRELIEITLVKNPAMR 260 >3HMP-A nrPDB Length = 342 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 113/272 (41%), Gaps = 22/272 (8%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF--RH 73 Y + +G G KV + A+K +N ++ + + + EI L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHS 115 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 II+LY T +MVME +L ++ K ++ E + ++ +L AV H+H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLY 190 +VH DLKP N L+ K+ DFG++N M + G+ NY PE I Sbjct: 175 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 191 AGP----------EVDIWSCGVILYALLCGTLPFDD--EHVPTLFKKIR-GGVFYIPEYL 237 + + D+WS G ILY + G PF + L I P+ Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + + +L L+ DP +R +I ++ H + + Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >4X3F-A nrPDB Length = 337 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 69/259 (26%), Positives = 111/259 (42%), Gaps = 9/259 (3%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 G G Y L + G G+V G +VAVK+L + + + + + E Sbjct: 4 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEA 63 Query: 66 QNLKLFRHPHIIKLYQVIS-----TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + + HP I ++ ++VME V+G L + + GR+ A + Sbjct: 64 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDML 123 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT--SCGSPN 178 +Q A+ H +VHRD+KP N+L+ KI DFG++ + +T G+ Sbjct: 124 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 183 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL-FKKIRGGVFYIPEYL 237 Y APE G A P D++S GV+ Y + G PF + T+ K I+ +P L Sbjct: 184 YIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDL 242 Query: 238 NRSVATLLMHMLQVDPLKR 256 +V L+ L +P R Sbjct: 243 PPNVRELIEITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 69/259 (26%), Positives = 111/259 (42%), Gaps = 9/259 (3%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 G G Y L + G G+V G +VAVK+L + + + + + E Sbjct: 24 PRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEA 83 Query: 66 QNLKLFRHPHIIKLYQVIS-----TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF 120 + + HP I ++ ++VME V+G L + + GR+ A + Sbjct: 84 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDML 143 Query: 121 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT--SCGSPN 178 +Q A+ H +VHRD+KP N+L+ KI DFG++ + +T G+ Sbjct: 144 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 203 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL-FKKIRGGVFYIPEYL 237 Y APE G A P D++S GV+ Y + G PF + T+ K I+ +P L Sbjct: 204 YIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDL 262 Query: 238 NRSVATLLMHMLQVDPLKR 256 +V L+ L +P R Sbjct: 263 PPNVRELIEITLVKNPAMR 281 >5AP3-A nrPDB Length = 313 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 113/272 (41%), Gaps = 22/272 (8%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF--RH 73 Y + +G G KV + A+K +N ++ + + + EI L Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHS 87 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 II+LY T +MVME +L ++ K ++ E + ++ +L AV H+H Sbjct: 88 DKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 146 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLY 190 +VH DLKP N L+ K+ DFG++N M + G+ NY PE I Sbjct: 147 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 205 Query: 191 AGP----------EVDIWSCGVILYALLCGTLPFDD--EHVPTLFKKIR-GGVFYIPEYL 237 + + D+WS G ILY + G PF + L I P+ Sbjct: 206 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 265 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + + +L L+ DP +R +I ++ H + + Sbjct: 266 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 297 >5UIU-A nrPDB Length = 323 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 64/268 (23%), Positives = 113/268 (42%), Gaps = 26/268 (9%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ-KIRSLDVVGKIKREIQNLKLFRHPHII 77 G+ +G G FG V G + VAVK L I + ++ + +EI+ + +H +++ Sbjct: 52 GNKMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLV 109 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYIC---KHGRVEEMEARRLFQQILSAVDYCHRHM 134 +L S D +V Y+ G L D + + ++ Q + +++ H + Sbjct: 110 ELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENH 169 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVISGRLYA 191 +HRD+K N+LLD AKI+DFGL+ + G+ Y APE + G + Sbjct: 170 HIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-- 227 Query: 192 GPEVDIWSCGVILYALLCGTLPFDDEHVPTLF---------------KKIRGGVFYIPEY 236 P+ DI+S GV+L ++ G D+ P L I + Sbjct: 228 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 287 Query: 237 LNRSVATLLMHMLQVDPLKRATIKDIRE 264 ++ ++ L KR IK +++ Sbjct: 288 SVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >3ZZW-A nrPDB Length = 289 Score = 215 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 111/272 (40%), Gaps = 29/272 (10%) Query: 17 VLGDTLGVGTFGKVKIGEH--QLTGHK---VAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 + LG FGKV G G + VA+K L + L + + E Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL--REEFRHEAMLRARL 69 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----------------VEEME 115 +HP+++ L V++ M+ Y S G+L +++ +E + Sbjct: 70 QHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPD 129 Query: 116 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG 175 L QI + ++Y H VVH+DL NVL+ +N KI+D GL + ++ + Sbjct: 130 FVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGN 189 Query: 176 SP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRG-GV 230 S + APE I + + DIWS GV+L+ + G P+ + + IR V Sbjct: 190 SLLPIRWMAPEAIMYGKF-SIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQV 248 Query: 231 FYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 P+ V L++ P +R KDI Sbjct: 249 LPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5AIR-A nrPDB Length = 430 Score = 215 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 110/304 (36%), Gaps = 47/304 (15%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y +G G+FG V + +G VA+K + L RE+Q ++ H + Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV-------LQDKRFKNRELQIMRKLDHCN 118 Query: 76 IIKLYQVIS------TPTDFFMVMEYVS---GGELFDYICKHGRVEEMEARRLFQQILSA 126 I++L +V++YV Y + + + Q+ + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 178 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 + Y H + HRD+KP+N+LLD K+ DFG + + GE + S Y APE+I Sbjct: 179 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 238 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLF------------KKIRG----- 228 G +D+WS G +L LL G F + ++IR Sbjct: 239 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 298 Query: 229 GVFYIP------------EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ-DLPSY 275 F P L +L+ P R T + H +F + P+ Sbjct: 299 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV 358 Query: 276 LFPE 279 P Sbjct: 359 KLPN 362 >3PG1-A nrPDB Length = 362 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 65/333 (19%), Positives = 112/333 (33%), Gaps = 52/333 (15%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQK--------IRSLDVVGKIKREI 65 Y + + G++G V G G VA+K + + + ++ REI Sbjct: 22 SPYTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREI 80 Query: 66 QNLKLFRHPHIIKLYQVISTPTD-----FFMVMEYVSGGELFDYICKHG-RVEEMEARRL 119 + L F HP+I+ L + + ++V E + +L I + + Sbjct: 81 RLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYF 139 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 179 IL + H VVHRDL P N+LL + + I DF L+ + Y Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWY 199 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV--------- 230 APE++ VD+WS G ++ + F KI V Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVV 259 Query: 231 -FYIP----------------------EYLNRSVATLLMHMLQVDPLKRATIKDIREHEW 267 F P + L+ ML+ +P +R + + H + Sbjct: 260 MFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPY 319 Query: 268 FKQDLPSYL----FPEDPSYDANVIDDEAVKEV 296 F+ E +D +V D + ++ Sbjct: 320 FESLFDPLDLTEGLSERFHFDESVTDVYDMHKI 352 >2ZMD-A nrPDB Length = 390 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 113/272 (41%), Gaps = 22/272 (8%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF--RH 73 Y + +G G KV + A+K +N ++ + + + EI L Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADN-QTLDSYRNEIAYLNKLQQHS 115 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 II+LY T +MVME +L ++ K ++ E + ++ +L AV H+H Sbjct: 116 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLY 190 +VH DLKP N L+ K+ DFG++N M + G+ NY PE I Sbjct: 175 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 191 AGP----------EVDIWSCGVILYALLCGTLPFDD--EHVPTLFKKIR-GGVFYIPEYL 237 + + D+WS G ILY + G PF + L I P+ Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 238 NRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + + +L L+ DP +R +I ++ H + + Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >3NIE-A nrPDB Length = 429 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 74/375 (19%), Positives = 125/375 (33%), Gaps = 94/375 (25%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y + +G G++G V + + VA+K +NR L +I REI L + Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRM-FEDLIDCKRILREITILNRLKS 86 Query: 74 PHIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 +II+L+ +I + ++V+E +L + E + + +L Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGEK 145 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG--------------------- 167 + H ++HRDLKP N LL+ + KI DFGL+ ++ Sbjct: 146 FIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPH 205 Query: 168 -----EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL----------CGTL 212 + L + + Y APE+I + +DIWS G I LL Sbjct: 206 NKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRF 265 Query: 213 P-FDDE-----------------HVPTLFKKIRGGVFYIPEY------------------ 236 P F I + PE Sbjct: 266 PLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFP 325 Query: 237 -------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 283 +++ LL ML+ + KR TI H + K L E+ S Sbjct: 326 TRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENL--ENFST 383 Query: 284 DANVIDDEAVKEVCE 298 + ++ + + E Sbjct: 384 EKIILPFDDWMVLSE 398 >4E7W-A nrPDB Length = 394 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 114/293 (38%), Gaps = 49/293 (16%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 Y +G G+FG V + + VA+K + L RE+Q +++ +HP+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKV-------LQDKRFKNRELQIMRIVKHPN 93 Query: 76 IIKLYQVISTPTD------FFMVMEYVSGGELF----DYICKHGRVEEMEARRLFQQILS 125 ++ L + D +V+EYV ++ Y + + + Q+L Sbjct: 94 VVDLKAFFYSNGDKKDEVFLNLVLEYVP-ETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAH-MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 ++ Y H + HRD+KP+N+LLD K+ DFG + ++ GE + S Y APE+ Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPEL 212 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH-------------------------- 218 I G +DIWS G ++ L+ G F E Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPN 272 Query: 219 -VPTLFKKIRGGVFY--IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + F +IR F L+ +L+ P R T + H +F Sbjct: 273 YMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >4F0G-A nrPDB Length = 287 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 72/269 (26%), Positives = 114/269 (42%), Gaps = 21/269 (7%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKIL----NRQKIRSLDVVGKIKREIQNL 68 +G G FG V G VA+K L + + ++ + +RE+ + Sbjct: 18 DNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIM 77 Query: 69 KLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAV 127 HP+I+KLY ++ P MVME+V G+L+ + ++ RL I + Sbjct: 78 SNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGI 135 Query: 128 DYCHRHM--VVHRDLKPENVLL-----DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 180 +Y +VHRDL+ N+ L +A + AK+ADFGLS + G+ + Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS--VSGLLGNFQWM 193 Query: 181 APEVI-SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL--FKKIR--GGVFYIPE 235 APE I + + D +S +ILY +L G PFD+ + IR G IPE Sbjct: 194 APETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPE 253 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDIRE 264 + ++ DP KR I + Sbjct: 254 DCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >5B2L-A nrPDB Length = 324 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 72/271 (26%), Positives = 120/271 (44%), Gaps = 16/271 (5%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN-LKL 70 +I +G GT G+V + TGH +AVK + R + + +I ++ LK Sbjct: 15 EINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG--NKEENKRILMDLDVVLKS 72 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVD 128 P+I++ + T TD F+ ME + G + + K G + E ++ I+ A+ Sbjct: 73 HDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKALY 130 Query: 129 YC-HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS- 186 Y +H V+HRD+KP N+LLD K+ DFG+S + D + S G Y APE I Sbjct: 131 YLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDP 190 Query: 187 ---GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP-TLFKKIRGGVFY-IPEYL--NR 239 + D+WS G+ L L G P+ + + K+ +P ++ + Sbjct: 191 PDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSG 250 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + + L D KR + EH + K+ Sbjct: 251 DFQSFVKDCLTKDHRKRPKYNKLLEHSFIKR 281 >5O0Y-A nrPDB Length = 579 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 75/269 (27%), Positives = 106/269 (39%), Gaps = 27/269 (10%) Query: 27 FGKVKIGEHQLTGHKVAVKI--LNR--QKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQV 82 F +V VAVKI LN+ + + + RE + K HP I+KLY Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 83 ISTPTD-FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR--HMVVHRD 139 S TD F V+EY G +L Y+ +H + E EAR + QI++A+ Y + ++H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 140 LKPENVLL---DAHMNAKIADFGLSNMMSDGEF--------LRTSCGSPNYAAPEVI--- 185 LKP N+LL A KI DFGLS +M D + G+ Y PE Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 186 SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPT------LFKKIRGGVFYIPEYLNR 239 +VD+WS GVI Y L G PF K F + Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTP 536 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWF 268 + L R ++ + + Sbjct: 537 EAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >3QA8-A nrPDB Length = 676 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 70/228 (30%), Positives = 107/228 (46%), Gaps = 16/228 (7%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + + + LG G FG V HQ TG +VA+K ++ S + EIQ +K H Sbjct: 14 GPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC--RQELSPKNRERWCLEIQIMKKLNH 71 Query: 74 PHIIKLYQV-----ISTPTDF-FMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQIL 124 P+++ +V P D + MEY GG+L Y+ + ++E R L I Sbjct: 72 PNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDIS 131 Query: 125 SAVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 SA+ Y H + ++HRDLKPEN++L + KI D G + + GE G+ Y A Sbjct: 132 SALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLA 191 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG 228 PE++ + Y VD WS G + + + G PF + K+R Sbjct: 192 PELLEQKKYT-VTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVRE 238 >4IDT-A nrPDB Length = 356 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 112/283 (39%), Gaps = 32/283 (11%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 LG G+FG+V E + TG + AVK + + R+ E+ P I+ LY Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA--------EELMACAGLTSPRIVPLYG 133 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 + + ME + GG L + + G + E A Q L ++Y H ++H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVK 193 Query: 142 PENVLLDAHM-NAKIADFGLSNMMSDGEFLRTSC------GSPNYAAPEVISGRLYAGPE 194 +NVLL + +A + DFG + + + G+ + APEV+ GR + Sbjct: 194 ADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRS-CDAK 252 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF---YIPEYLNRSVATLLMHMLQV 251 VD+WS ++ +L G P+ L KI IP A + L+ Sbjct: 253 VDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRK 312 Query: 252 DPLKRATIKDI-------------REHEWFKQDLPSYLFPEDP 281 +P+ R + ++ + W + P + Sbjct: 313 EPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQ 355 >4FL3-A nrPDB Length = 635 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 100/250 (40%), Gaps = 9/250 (3%) Query: 20 DTLGVGTFGKVKIGEHQ-LTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G FG VK G +Q K + + + + ++ E ++ +P+I++ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 + + + +VME G L Y+ ++ V++ L Q+ + Y VHR Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS----PNYAAPEVISGRLYAGPE 194 DL NVLL AKI+DFGLS + E + + APE I+ ++ + Sbjct: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-K 552 Query: 195 VDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVD 252 D+WS GV+++ G P+ + + G P R + L+ D Sbjct: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 Query: 253 PLKRATIKDI 262 R + Sbjct: 613 VENRPGFAAV 622 >6CTH-A nrPDB Length = 309 Score = 211 bits (538), Expect = 5e-55, Method: Composition-based stats. Identities = 66/276 (23%), Positives = 126/276 (45%), Gaps = 30/276 (10%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 ++ + LG G FG V G + + +AVK ++R S + + E++ + RH Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGIKEYASEVKIISRLRH 71 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEAR-RLFQQILSAVDYCHR 132 +++KL + +V E+++ G L +I K + E R R+ + + SA+ Y H Sbjct: 72 KNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHE 131 Query: 133 ---HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS--CGSPNYAAPEVISG 187 H V+HRD+K N++LD+ NAK+ DFGL+ ++ + L+ + G+ Y APE +S Sbjct: 132 EGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSS 191 Query: 188 RLYAGPEVDIWSCGVILYALLCGT---------------LPF-DDEHVPTLFKKIRGGVF 231 A E D++S GV+ + G +P+ + + I Sbjct: 192 GK-ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKL 250 Query: 232 YIPEYLNRSVATL-LMHMLQVDPLK--RATIKDIRE 264 + + + + L ++ + P R +I+ + + Sbjct: 251 GM-AFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQ 285 >3E3P-A nrPDB Length = 360 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 127/330 (38%), Gaps = 61/330 (18%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R ++ + + G GTFG V++G+ + TG VA+K + I+ + + +Q+L Sbjct: 19 RKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV----IQDPRFRNRELQIMQDLA 74 Query: 70 LFRHPHIIKLYQVIST-----PTDFFM--VMEYVS---GGELFDYICKHGRVEEMEARRL 119 + HP+I++L T D ++ VMEYV +Y + + + Sbjct: 75 VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVF 134 Query: 120 FQQILSAVDYCH--RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGS 176 Q++ ++ H V HRD+KP NVL++ K+ DFG + +S E S Sbjct: 135 LFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICS 194 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY 236 Y APE+I G + VDIWS G I ++ G F ++ +I + Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 237 L--------------------------------NRSVATLLMHMLQVDPLKRATIKDIRE 264 + + LL +LQ P +R + Sbjct: 255 VLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALC 314 Query: 265 HEWF------------KQDLPSYLFPEDPS 282 H +F +DLP LF P+ Sbjct: 315 HPYFDELHDPATKLPNNKDLPEDLFRFLPN 344 >3LMG-A nrPDB Length = 344 Score = 210 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 120/285 (42%), Gaps = 19/285 (6%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGH----KVAVKIL-NRQKIRSLDVVGKIKREI 65 K LG G FG V G G V +K++ ++ +S V I Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQQIL 124 H HI++L + + +V +Y+ G L D++ +H G + QI Sbjct: 88 ---GSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIA 143 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM--SDGEFLRTSCGSP-NYAA 181 + Y H +VHR+L NVLL + ++ADFG+++++ D + L + +P + A Sbjct: 144 KGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMA 203 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNR 239 E I Y + D+WS GV ++ L+ G P+ + + + G P+ Sbjct: 204 LESIHFGKYTH-QSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTI 262 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEW--FKQDLPSYLFPEDPS 282 V +++ +D R T K+ +E+ +D P YL + S Sbjct: 263 DVYMVMVKCWMIDENIRPTFKE-LANEFTRMARDPPRYLVIKRES 306 >5TQX-A nrPDB Length = 655 Score = 210 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 75/281 (26%), Positives = 119/281 (42%), Gaps = 44/281 (15%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + + + LG G FG V + +H+ K+A+K + S + EIQ +K H Sbjct: 8 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLE--LSTKNRERWCHEIQIMKKLNH 65 Query: 74 PHIIKLYQVISTPTDF--------FMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQ 122 +++K P + + MEY SGG+L + K ++E + L Sbjct: 66 ANVVK---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 123 ILSAVDYCHRHMVVHRDLKPENVLL-DAHMNA--KIADFGLSNMMSDGEFLRTSCGSPNY 179 I S + Y H + ++HRDLKPEN++L D KI D G + + GE G+ Y Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQY 182 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG---------- 228 APE+ + Y VD WS G +++ + G PF T +KI+ Sbjct: 183 LAPELFENKPYT-ATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACE 241 Query: 229 ---GVFYIPEYLNR--SVATLL--------MHMLQVDPLKR 256 G +L + S+ +L+ ML DP +R Sbjct: 242 EMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >5TOS-A nrPDB Length = 395 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 117/294 (39%), Gaps = 46/294 (15%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIG---------EHQLTGHKVAVKILNRQKIRSLDVVGK 60 ++ ++ +G G FG V G TG +AVK LN++ + + Sbjct: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HRE 117 Query: 61 IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG----RVEEMEA 116 EI L HP+++KL +V E++ G L +++ + G + Sbjct: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 117 RRLFQQILSAVDYCHRH--MVVHRDLKPENVLLDAHMNAKIADFGLSNM--MSDGEFLRT 172 + + + H V++RD+K N+LLDA NAK++DFGL+ M D ++ T Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 Query: 173 SC-GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGT------------------LP 213 G+ YAAPE +S + D++S GV+L +L G P Sbjct: 238 RVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 Query: 214 FDDEHVPTLFKKIRGGVFYIPEYLNRSV---ATLLMHMLQVDPLKRATIKDIRE 264 + L I +YL A++ + L +P R T+ + Sbjct: 297 YLTSKRKVLL--IVDNRLDT-QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 >5C26-A nrPDB Length = 299 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 100/250 (40%), Gaps = 9/250 (3%) Query: 20 DTLGVGTFGKVKIGEHQ-LTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 LG G FG VK G +Q K + + + + ++ E ++ +P+I++ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 138 + + + +VME G L Y+ ++ V++ L Q+ + Y VHR Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 151 Query: 139 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS----PNYAAPEVISGRLYAGPE 194 DL NVLL AKI+DFGLS + E + + APE I+ ++ + Sbjct: 152 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-K 210 Query: 195 VDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG-VFYIPEYLNRSVATLLMHMLQVD 252 D+WS GV+++ G P+ + + G P R + L+ D Sbjct: 211 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 270 Query: 253 PLKRATIKDI 262 R + Sbjct: 271 VENRPGFAAV 280 >4KIK-B nrPDB Length = 677 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 114/281 (40%), Gaps = 39/281 (13%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G + + + LG G FG V +Q TG ++A+K ++ S + EIQ ++ H Sbjct: 19 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQC--RQELSPRNRERWCLEIQIMRRLTH 76 Query: 74 PHIIKLYQVISTPTDF------FMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQIL 124 P+++ V + + MEY GG+L Y+ + + E L I Sbjct: 77 PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 136 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHMN---AKIADFGLSNMMSDGEFLRTSCGSPNYAA 181 SA+ Y H + ++HRDLKPEN++L KI D G + + G + G+ Y A Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLA 196 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRG------------ 228 PE++ + Y VD WS G + + + G PF + K+R Sbjct: 197 PELLEQQKYT-VTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDL 255 Query: 229 -------GVFYIPEYLNRSVATLLMH----MLQVDPLKRAT 258 P LN +A L ML P +R T Sbjct: 256 NGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >4Y83-A nrPDB Length = 332 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 66/255 (25%), Positives = 116/255 (45%), Gaps = 18/255 (7%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 D + G FGKV + + T ++A K++ + + DV EIQ FRH +I +L Sbjct: 79 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDV------EIQ--ACFRHENIAEL 130 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 139 Y + + ME GG + + + G + E E + + +L +D+ H V+H D Sbjct: 131 YGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHD 190 Query: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSPNYAAPEVISGRLYAGPEVDIW 198 +KP N++ + + DFGLS M++ + + G+ Y +PEVI R ++ + DI+ Sbjct: 191 IKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHST-KADIY 248 Query: 199 SCGVILYALLCGTLP----FDDEHVPTLFKKIRGGVFYIP---EYLNRSVATLLMHMLQV 251 S G L + GT P + P+ I + + + + L+ L+ Sbjct: 249 SLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLER 308 Query: 252 DPLKRATIKDIREHE 266 +P R D+ +HE Sbjct: 309 NPNHRPRAADLLKHE 323 >2A1A-B nrPDB Length = 284 Score = 209 bits (531), Expect = 4e-54, Method: Composition-based stats. Identities = 75/278 (26%), Positives = 120/278 (43%), Gaps = 33/278 (11%) Query: 7 HDGRVKIG-HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 H + G + + +G G FG+V +H++ G +K + K +RE+ Sbjct: 3 HTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAEREV 55 Query: 66 QNLKLFRHPHIIKLYQVI----------------STPTDFFMVMEYVSGGELFDYICKHG 109 + L H +I+ S F+ ME+ G L +I K Sbjct: 56 KALAKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 115 Query: 110 --RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG 167 +++++ A LF+QI VDY H +++RDLKP N+ L KI DFGL + + Sbjct: 116 GEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKND 175 Query: 168 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL-CGTLPFDDEHVPTLFKKI 226 S G+ Y +PE IS + Y G EVD+++ G+IL LL F+ F + Sbjct: 176 GKRTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFE---TSKFFTDL 231 Query: 227 RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 R G+ I + ++ TLL +L P R +I Sbjct: 232 RDGI--ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >4M7I-A nrPDB Length = 299 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 114/298 (38%), Gaps = 41/298 (13%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + LG G FG V ++++ A+K + K+ RE++ L Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRE--LAREKVMREVKALAKLE 61 Query: 73 HPHIIKLYQVISTPT------------DFFMVMEYVSGGELFDYICKHGRVEEME---AR 117 HP I++ + ++ M+ L D++ +EE E Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT----- 172 +F QI AV++ H ++HRDLKP N+ K+ DFGL M E +T Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 173 --------SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLF 223 G+ Y +PE I G Y+ +VDI+S G+IL+ LL PF Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNSYSH-KVDIFSLGLILFELL---YPFSTQMERVRTL 237 Query: 224 KKIRGGVFYIPEYLN---RSVATLLMHMLQVDPLKRATIKDIREHEWFKQ-DLPSYLF 277 +R P ++ ML P++R +I E+ F+ D P Sbjct: 238 TDVRN--LKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTV 293 >5WNL-A nrPDB Length = 342 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 19/267 (7%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 G + + +G G FG+V H +A+K + + + + E + +++ Sbjct: 17 FDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERME-LLEEAKKMEM 75 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 + +I+ +Y + P +VMEY+ G L + + R+ + +++ Sbjct: 76 AKFRYILPVYGICQEPVG--LVMEYMETGSLEKLLASE-PLPWDLRFRIVHETAVGMNFL 132 Query: 131 H--RHMVVHRDLKPENVLLDAHMNAKIADFGLSN----MMSDGEFLRTSCGSPNYAAPEV 184 H ++H +LKP N+LLDAH + KI+DFGL+ S + G+ Y PE Sbjct: 133 HCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPER 192 Query: 185 ISGRLY-AGPEVDIWSCGVILYALLCGTLPFDDEHV--PTLFKKIRGGVFYIPEYLNR-- 239 I + + D++S ++++ +L PF DE + K ++G +P Sbjct: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRP 252 Query: 240 ----SVATLLMHMLQVDPLKRATIKDI 262 S+ L+ DP R T ++I Sbjct: 253 RACASLIGLMQRCWHADPQVRPTFQEI 279 >5X8I-B nrPDB Length = 346 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 78/334 (23%), Positives = 126/334 (37%), Gaps = 80/334 (23%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGE-HQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 G V Y + DTLG G FGKV H+ G VAVKI+ + EI Sbjct: 6 QSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD----RYCEAARSEI 61 Query: 66 QNLKLFR--HPH----IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVE--EMEAR 117 Q L+ P+ +++ + +V E + G +D+I ++G + R Sbjct: 62 QVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIR 120 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDA-------------------HMNAKIADF 158 ++ QI +V++ H + + H DLKPEN+L + + K+ DF Sbjct: 121 KMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDF 180 Query: 159 GLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH 218 G + D E T + +Y APEVI ++ P D+WS G IL G F Sbjct: 181 GSATY--DDEHHSTLVSTRHYRAPEVILALGWSQP-CDVWSIGCILIEYYLGFTVFPTHD 237 Query: 219 VPTLFKKIRGGVFYIPE---------------------------YLNRSVA--------- 242 + + +P+ Y++R+ Sbjct: 238 SKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQ 297 Query: 243 --------TLLMHMLQVDPLKRATIKDIREHEWF 268 L+ ML+ DP KR T+++ +H +F Sbjct: 298 DVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >3EB0-A nrPDB Length = 383 Score = 205 bits (521), Expect = 6e-53, Method: Composition-based stats. Identities = 74/325 (22%), Positives = 112/325 (34%), Gaps = 78/325 (24%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y LG TLG G+FG V +G + A+K + L RE+ +K+ H Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV-------LQDPRYKNRELDIMKVLDHV 60 Query: 75 HIIKLYQVIST--------------------------------------PTDFFMVMEYV 96 +IIKL T ++MEYV Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 97 S---GGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA-HMN 152 L +I + Q+ AV + H + HRD+KP+N+L+++ Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 153 AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL 212 K+ DFG + + E S Y APE++ G P +D+WS G + L+ G Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKP 240 Query: 213 PFDDEH-------------VPTLFKKIRGGVFY----------------IPEYLNRSVAT 243 F E PT + IR Y +PE Sbjct: 241 LFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAID 300 Query: 244 LLMHMLQVDPLKRATIKDIREHEWF 268 LL +L+ +P R + H +F Sbjct: 301 LLEQILRYEPDLRINPYEAMAHPFF 325 >3UIU-A nrPDB Length = 306 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 122/294 (41%), Gaps = 46/294 (15%) Query: 4 KQKHDGRVKIG-HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK 62 + K+ + G + + +G G FG+V +H++ G ++ + K + Sbjct: 1 ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN-------EKAE 53 Query: 63 REIQNLKLFRHPHIIKLYQVI-----------------------------STPTDFFMVM 93 RE++ L H +I+ S F+ M Sbjct: 54 REVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQM 113 Query: 94 EYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHM 151 E+ G L +I K +++++ A LF+QI VDY H ++HRDLKP N+ L Sbjct: 114 EFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTK 173 Query: 152 NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL-CG 210 KI DFGL + + S G+ Y +PE IS + Y G EVD+++ G+IL LL Sbjct: 174 QVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVC 232 Query: 211 TLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 F+ F +R G+ I + ++ TLL +L P R +I Sbjct: 233 DTAFE---TSKFFTDLRDGI--ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >5CEK-A nrPDB Length = 263 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 74/248 (29%), Positives = 118/248 (47%), Gaps = 13/248 (5%) Query: 30 VKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF 89 V TG ++ K+ + + ++L H +I + +VI T Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRP--------YIQLPSHSNITGIVEVILGETKA 76 Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 ++ E G++ Y+ R+ E EA RLF+QI+SAV +CH+ +V DLK + Sbjct: 77 YVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 135 Query: 150 HMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVISGR-LYAGPEVDIWSCGVILY 205 ++ L + M + + L G P Y +PE+++ Y+G D+WS GV+LY Sbjct: 136 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 195 Query: 206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LL G PF D LF KIR G F IPE+++ L+ +L+ +P +R T +I H Sbjct: 196 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 255 Query: 266 EWFKQDLP 273 WF+ L Sbjct: 256 PWFESVLE 263 >6DC0-A nrPDB Length = 292 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 74/248 (29%), Positives = 118/248 (47%), Gaps = 13/248 (5%) Query: 30 VKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF 89 V TG ++ K+ + + ++L H +I + +VI T Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRP--------YIQLPSHSNITGIVEVILGETKA 73 Query: 90 FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 ++ E G++ Y+ R+ E EA RLF+QI+SAV +CH+ +V DLK + Sbjct: 74 YVFFEK-DFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 132 Query: 150 HMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVISGR-LYAGPEVDIWSCGVILY 205 ++ L + M + + L G P Y +PE+++ Y+G D+WS GV+LY Sbjct: 133 EERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLY 192 Query: 206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 LL G PF D LF KIR G F IPE+++ L+ +L+ +P +R T +I H Sbjct: 193 TLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLH 252 Query: 266 EWFKQDLP 273 WF+ L Sbjct: 253 PWFESVLE 260 >2WTK-B nrPDB Length = 373 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 128/337 (37%), Gaps = 73/337 (21%) Query: 14 GHYVLGDTLGVGTF---GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 G Y L +G G F V + ++ TG V V+ +N + S ++V ++ E+ KL Sbjct: 9 GCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-SNEMVTFLQGELHVSKL 66 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVD 128 F HP+I+ + ++V +++ G D IC H + E+ + Q +L A+D Sbjct: 67 FNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALD 126 Query: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNY------ 179 Y H VHR +K ++L+ ++ GL +M+S G+ R P Y Sbjct: 127 YIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLP 184 Query: 180 -AAPEVISGRLY-AGPEVDIWSCGVILYALLCGTLPFDDEH-VPTLFKKIRGGVFYI--- 233 +PEV+ L + DI+S G+ L G +PF D L +K+ G V + Sbjct: 185 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 234 -------------------------------------PEY-----LNRSVATLLMHMLQV 251 P + + + LQ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 252 DPLKRATIKDIREHEWFKQ-------DLPSYLFPEDP 281 +P R + + H +FKQ LP L P P Sbjct: 305 NPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTP 341 >6O6Q-A nrPDB Length = 335 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 119/296 (40%), Gaps = 50/296 (16%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF-R 72 +Y + LG G + +V +G KV +K+L K KIKREI LK Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVK------RKKIKREISILKNLVD 94 Query: 73 HPHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 P+II + V+ P ++ E+++ + + + + R ++L A+DY Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL---YPTFTDYDIRFYMYELLKALDYS 151 Query: 131 HRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 H ++HRD+KP NV++D ++ D+GL+ G S + PE++ Sbjct: 152 HSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYR 211 Query: 190 YAGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIR------------------GG 229 +D+WS G +L +++ PF + L + +R G Sbjct: 212 LYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGE 271 Query: 230 VFY-----------------IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + + +++ L+ +L+ D +R T K+ +H +F Sbjct: 272 EYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >3RP9-A nrPDB Length = 458 Score = 201 bits (511), Expect = 7e-52, Method: Composition-based stats. Identities = 68/362 (18%), Positives = 120/362 (33%), Gaps = 98/362 (27%) Query: 4 KQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 + D ++ Y + +G G++G V +L VA+K + + L +I R Sbjct: 44 RPHSDWQIP-DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI-LRVFEDLIDCKRILR 101 Query: 64 EIQNLKLFRHPHIIKLYQVISTPT-----DFFMVMEYVSGGELFDYICKHGRVEEMEARR 118 EI L H H++K+ ++ + ++V+E + + E+ + Sbjct: 102 EIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIAD-SDFKKLFRTPVYLTELHIKT 160 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---------- 168 L +L V Y H ++HRDLKP N L++ + K+ DFGL+ + E Sbjct: 161 LLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISP 220 Query: 169 ------------------FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC- 209 L + Y APE+I + +D+WS G I LL Sbjct: 221 REDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNM 280 Query: 210 ----------GTLPFDD------------------------EHVPTLFKKI--------- 226 F + + +F + Sbjct: 281 IKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIE 340 Query: 227 -------RGGVFYIPE--------YLNRSVATLLMHM---LQVDPLKRATIKDIREHEWF 268 + + P+ S A + + L +P KR TI + H +F Sbjct: 341 ALEKEDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFF 400 Query: 269 KQ 270 K+ Sbjct: 401 KE 402 >5LPZ-A nrPDB Length = 332 Score = 200 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 64/270 (23%), Positives = 113/270 (41%), Gaps = 32/270 (11%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G FG V + G VA+K L + + E++ + +H +++ L Sbjct: 24 LIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD---REFMAEMETIGKIKHRNLVPLL 79 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYCH---RH 133 + +V E++ G L D + + + R++ + + H Sbjct: 80 GYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLY 190 ++HRD+K NVLLD ++ A+++DFG++ +MS + + T G+P Y PE Sbjct: 140 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ-SFR 198 Query: 191 AGPEVDIWSCGVILYALLCGTLP-----FDDEHVPTLFK---KIRGGVFYIPEYLNRSVA 242 + D++S GV+L LL G P F D ++ K K+R + PE + A Sbjct: 199 CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPA 258 Query: 243 ---TLLMH------MLQVDPLKRATIKDIR 263 LL H L +R T+ + Sbjct: 259 LEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >5LPV-A nrPDB Length = 296 Score = 200 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 64/270 (23%), Positives = 113/270 (41%), Gaps = 32/270 (11%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G FG V + G VA+K L + + E++ + +H +++ L Sbjct: 24 LIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD---REFMAEMETIGKIKHRNLVPLL 79 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYCH---RH 133 + +V E++ G L D + + + R++ + + H Sbjct: 80 GYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSP 139 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLY 190 ++HRD+K NVLLD ++ A+++DFG++ +MS + + T G+P Y PE Sbjct: 140 HIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ-SFR 198 Query: 191 AGPEVDIWSCGVILYALLCGTLP-----FDDEHVPTLFK---KIRGGVFYIPEYLNRSVA 242 + D++S GV+L LL G P F D ++ K K+R + PE + A Sbjct: 199 CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPA 258 Query: 243 ---TLLMH------MLQVDPLKRATIKDIR 263 LL H L +R T+ + Sbjct: 259 LEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >4G3E-A nrPDB Length = 352 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 65/253 (25%), Positives = 109/253 (43%), Gaps = 19/253 (7%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 81 +G G+FG+V + + TG + AVK + + R E+ P I+ LY Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR--------VEELVACAGLSSPRIVPLYG 133 Query: 82 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLK 141 + + ME + GG L I + G + E A Q L ++Y H ++H D+K Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVK 193 Query: 142 PENVLLDAHM-NAKIADFGLSNMMSDGEFLRTSC------GSPNYAAPEVISGRLYAGPE 194 +NVLL + A + DFG + + ++ G+ + APEV+ G+ + Sbjct: 194 ADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKP-CDAK 252 Query: 195 VDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG---GVFYIPEYLNRSVATLLMHMLQV 251 VDIWS ++ +L G P+ L KI + IP A + L+ Sbjct: 253 VDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRK 312 Query: 252 DPLKRATIKDIRE 264 +P+ RA+ ++R Sbjct: 313 EPVHRASAMELRR 325 >5VD3-A nrPDB Length = 311 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 64/261 (24%), Positives = 111/261 (42%), Gaps = 15/261 (5%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF-RHP 74 + LG G++G+V + G AVK + R + E+ + + +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVGQHP 117 Query: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILSAVDYCHRH 133 ++L Q ++ E G L + G + E + + L A+ + H Sbjct: 118 CCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGP 193 +VH D+KP N+ L K+ DFGL + G P Y APE++ G G Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--YGT 234 Query: 194 EVDIWSCGVILYALLCG-TLPFDDEHVPTLFKKIRGGVFYIPEY---LNRSVATLLMHML 249 D++S G+ + + C LP E ++++R G PE+ L+ + ++L+ ML Sbjct: 235 AADVFSLGLTILEVACNMELPHGGEG----WQQLRQGYLP-PEFTAGLSSELRSVLVMML 289 Query: 250 QVDPLKRATIKDIREHEWFKQ 270 + DP RAT + + +Q Sbjct: 290 EPDPKLRATAEALLALPVLRQ 310 >3MY0-A nrPDB Length = 305 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 114/291 (39%), Gaps = 51/291 (17%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 L + +G G +G+V G G VAVKI + + +S + EI N L RH +I+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFR----ETEIYNTVLLRHDNIL 65 Query: 78 KLYQVISTP----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH-- 131 T T +++ Y G L+D++ + +E A RL + + H Sbjct: 66 GFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ-TLEPHLALRLAVSAACGLAHLHVE 124 Query: 132 ------RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-----RTSCGSPNYA 180 + + HRD K NVL+ +++ IAD GL+ M S G G+ Y Sbjct: 125 IFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYM 184 Query: 181 APEVISGRLYAG-----PEVDIWSCGVILYALLCG----------TLPFDD----EHVPT 221 APEV+ ++ DIW+ G++L+ + PF D + Sbjct: 185 APEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFE 244 Query: 222 LFKKIR---GGVFYIPEYLNRS-----VATLLMHMLQVDPLKRATIKDIRE 264 KK+ IP L +A ++ +P R T I++ Sbjct: 245 DMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 295 >3Q4U-A nrPDB Length = 301 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 117/299 (39%), Gaps = 51/299 (17%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R L + +G G +G+V G Q G VAVKI + + +S + E+ N Sbjct: 4 RTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFR----ETELYNTV 57 Query: 70 LFRHPHIIKLYQVISTPTD----FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 + RH +I+ T +++ Y G L+DY+ ++ + R+ I S Sbjct: 58 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQL-TTLDTVSCLRIVLSIAS 116 Query: 126 AVDYCH--------RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-----RT 172 + + H + + HRDLK +N+L+ + IAD GL+ M S Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 173 SCGSPNYAAPEVISGRLYAG-----PEVDIWSCGVILYALLCG----------TLPFDD- 216 G+ Y APEV+ + VDIW+ G++L+ + PF D Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV 236 Query: 217 ---EHVPTLFKKIR---GGVFYIP-EYLNR----SVATLLMHMLQVDPLKRATIKDIRE 264 + +K+ IP + + S+A L+ +P R T I++ Sbjct: 237 VPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >2BUJ-A nrPDB Length = 317 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 119/312 (38%), Gaps = 42/312 (13%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 64 Q H + HY+ LG G F V + E GH A+K + + +RE Sbjct: 20 QGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LCHEQQDREEAQRE 76 Query: 65 IQNLKLFRHPHIIKLYQVISTPT----DFFMVMEYVSGGELFDYIC----KHGRVEEMEA 116 +LF HP+I++L + ++++ + G L++ I K + E + Sbjct: 77 ADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQI 136 Query: 117 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL----------SNMMSD 166 L I ++ H HRDLKP N+LL + D G S Sbjct: 137 LWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALT 196 Query: 167 GEFLRTSCGSPNYAAPEVISGRLYA--GPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK 224 + + +Y APE+ S + + D+WS G +LYA++ G P+D +F+ Sbjct: 197 LQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD-----MVFQ 251 Query: 225 K------IRGGVFYIPEYL--NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276 K IP+ + ++ LL M+ VDP +R I L + Sbjct: 252 KGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHI------PLLLSQLEALQ 305 Query: 277 FPEDPSYDANVI 288 P + ++ Sbjct: 306 PPAPGQHTTQIL 317 >6FYV-A nrPDB Length = 337 Score = 198 bits (503), Expect = 6e-51, Method: Composition-based stats. Identities = 73/334 (21%), Positives = 122/334 (36%), Gaps = 80/334 (23%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ-LTGHKVAVKILNRQKIRSLDVVGKIKREI 65 G V Y + DTLG G FGKV + G VAVKI+ + EI Sbjct: 7 QSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG----RYREAARSEI 62 Query: 66 QNLKLFRH--PH----IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE--MEAR 117 Q L+ P+ +++ + +V E + G +D+I ++ + R Sbjct: 63 QVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIR 121 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVLLD-------------------AHMNAKIADF 158 ++ QI ++++ H + + H DLKPEN+L + + K+ DF Sbjct: 122 QMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDF 181 Query: 159 GLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH 218 G + D E T + +Y APEVI ++ P D+WS G IL G F Sbjct: 182 GSATY--DDEHHSTLVSTRHYRAPEVILALGWSQP-CDVWSIGCILIEYYLGFTVFQTHD 238 Query: 219 VPTLFKKIRGGVFYIPEYL----------------------------------------- 237 + + IP+++ Sbjct: 239 SKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCH 298 Query: 238 ---NRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 + + L+ ML+ DP +R T+ + +H +F Sbjct: 299 DEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >6J5U-C nrPDB Length = 426 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 114/285 (40%), Gaps = 42/285 (14%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLT---------GHKVAVKILNRQKIRSLDVVGKIKREI 65 ++ + LG G FG V G T G VAVK L + + + E+ Sbjct: 85 NFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQG---HKEWLTEV 141 Query: 66 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI-- 123 L HP+++ L + + +V E++ G L +++ + G A R+ + Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 124 LSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL---RTSCGSPN 178 + + H V++RD K N+LLDA NAK++DFGL+ G+ G+ Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHG 261 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL------------------PFDDEHVP 220 YAAPE ++ + D++S GV+L L+ G P+ + Sbjct: 262 YAAPEYVA-TGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRK 320 Query: 221 --TLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 + GG + P+ + A L + L D R + ++ Sbjct: 321 LFRIMDTKLGGQY--PQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >4C59-A nrPDB Length = 340 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 124/298 (41%), Gaps = 40/298 (13%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-H 73 + L G F V + +G + A+K L + I +E+ +K H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL---LSNEEEKNRAIIQEVCFMKKLSGH 84 Query: 74 PHIIKL-----YQVISTPT---DFFMVMEYVSGGELFDYICK---HGRVEEMEARRLFQQ 122 P+I++ + T +F ++ E G+L +++ K G + ++F Q Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQLVEFLKKMESRGPLSCDTVLKIFYQ 143 Query: 123 ILSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--------- 171 AV + HR ++HRDLK EN+LL K+ DFG + +S Sbjct: 144 TCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALV 203 Query: 172 ----TSCGSPNYAAPEVIS--GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 T +P Y PE+I G + DIW+ G ILY L PF+D + Sbjct: 204 EEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFED----GAKLR 259 Query: 226 IRGGVFYIPEYLNRS--VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDP 281 I G + IP + + +L+ MLQV+P +R +I ++ H+ + + P+ P Sbjct: 260 IVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVV-HQLQEIAAARNVNPKSP 316 >2PMN-X nrPDB Length = 348 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 127/314 (40%), Gaps = 52/314 (16%) Query: 1 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK 60 + EK K+ I Y + TL G F K+ + E A+K + + K Sbjct: 23 VKEKDKY-----INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTK 75 Query: 61 --------------IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDY-- 104 K E+Q + ++ + + +I+ + +++ EY+ + + Sbjct: 76 SNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDE 135 Query: 105 ----ICKH--GRVEEMEARRLFQQILSAVDYCH-RHMVVHRDLKPENVLLDAHMNAKIAD 157 + K+ + + + + +L++ Y H + HRD+KP N+L+D + K++D Sbjct: 136 YFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSD 195 Query: 158 FGLSNMMSDGEFLRTSCGSPNYAAPEVISGR-LYAGPEVDIWSCGVILYALLCGTLPFD- 215 FG S M D + ++ S G+ + PE S Y G +VDIWS G+ LY + +PF Sbjct: 196 FGESEYMVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSL 254 Query: 216 DEHVPTLFKKIRGGVFYIP-------------------EYLNRSVATLLMHMLQVDPLKR 256 + LF IR P +L+ L L+ +P +R Sbjct: 255 KISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAER 314 Query: 257 ATIKDIREHEWFKQ 270 T +D +HEW Sbjct: 315 ITSEDALKHEWLAD 328 >5ZTN-A nrPDB Length = 429 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 113/329 (34%), Gaps = 77/329 (23%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74 Y + +G G+FG+V VA+K++ +K + EI+ L+ R Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEK----RFHRQAAEEIRILEHLRKQ 153 Query: 75 ------HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSA 126 ++I + + + M E +S L++ I K+ R+ IL Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 127 VDYCHRHMVVHRDLKPENVLLDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 +D H++ ++H DLKPEN+LL K+ DFG S + + + T S Y APEV Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCY--EHQRVYTYIQSRFYRAPEV 270 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV-PTLFKKIRGGVFY----------- 232 I G Y P +D+WS G IL LL G E L I Sbjct: 271 ILGARYGMP-IDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRA 329 Query: 233 --------IPEYL---------------------------NRSVATLLMHM--------- 248 P Y +R L Sbjct: 330 KNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFL 389 Query: 249 ---LQVDPLKRATIKDIREHEWFKQDLPS 274 L+ DP R T H W ++ LP Sbjct: 390 KQCLEWDPAVRMTPGQALRHPWLRRRLPK 418 >4EUU-A nrPDB Length = 319 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 22/237 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++L D LG G V G H+ TG A+K+ N V RE + LK H + Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 68 Query: 76 IIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 130 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 131 HRHMVVHRDLKPENVL--LDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + +VHR++KP N++ + K+ DFG + + D E + G+ Y P++ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 188 Query: 187 G-------RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFY 232 + G VD+WS GV Y G+LPF + KI G Sbjct: 189 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >4JLC-A nrPDB Length = 657 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 61/237 (25%), Positives = 101/237 (42%), Gaps = 22/237 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++L D LG G V G H+ TG AVK+ N V RE + LK H + Sbjct: 10 WLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 67 Query: 76 IIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 130 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 68 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 127 Query: 131 HRHMVVHRDLKPENVL--LDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + +VHRD+KP N++ + K+ DFG + + D E + G+ Y P++ Sbjct: 128 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 187 Query: 187 G-------RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFY 232 + G VD+WS GV Y G+LPF + KI G Sbjct: 188 RAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >3UIM-A nrPDB Length = 326 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 65/283 (22%), Positives = 123/283 (43%), Gaps = 32/283 (11%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 +V ++ + LG G FGKV G G VAVK L ++ + ++ + + E++ + Sbjct: 26 QVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGEL--QFQTEVEMIS 82 Query: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGE----LFDYICKHGRVEEMEARRLFQQILS 125 + H ++++L TPT+ +V Y++ G L + ++ + +R+ Sbjct: 83 MAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSAR 142 Query: 126 AVDYCHRH---MVVHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSPNYA 180 + Y H H ++HRD+K N+LLD A + DFGL+ +M D G+ + Sbjct: 143 GLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHI 202 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD-----DEHVPTLFKKIRGGVFYIP- 234 APE +S + + D++ GV+L L+ G FD ++ L ++G + Sbjct: 203 APEYLS-TGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKL 261 Query: 235 ----------EYLNRSVATLLM---HMLQVDPLKRATIKDIRE 264 Y + V L+ Q P++R + ++ Sbjct: 262 EALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVR 304 >5IKW-A nrPDB Length = 310 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 119/269 (44%), Gaps = 32/269 (11%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPH 75 L ++L G F V + G + A+K + + L+V KREI +K H + Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVC---KREITIMKELSGHKN 72 Query: 76 IIKLYQV----ISTPT-DFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVD 128 I+ IS + ++MEY G++ + + K E E ++F AV Sbjct: 73 IVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVA 132 Query: 129 YCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLS--NMMSDGEFLRTSC-------GSP 177 H+ ++HRDLK EN+LL+ N + DFG + ++ + + Sbjct: 133 RLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTL 192 Query: 178 NYAAPEVIS--GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE 235 +Y APE+I+ G + DIW+ G +LY L TLPF + V I G F IP+ Sbjct: 193 SYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVA-----ICDGNFTIPD 247 Query: 236 Y--LNRSVATLLMHMLQVDPLKRATIKDI 262 +R++ L+ ML+ DP R I + Sbjct: 248 NSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >2Y4I-B nrPDB Length = 319 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 119/277 (42%), Gaps = 28/277 (10%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 66 + + +G+ +G G FG+V G +VA+++++ ++ + D + KRE+ Sbjct: 26 QEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIER-DNEDQLKAFKREVM 81 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-RVEEMEARRLFQQILS 125 + RH +++ +P ++ G L+ + ++ + R++ Q+I+ Sbjct: 82 AYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVK 141 Query: 126 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL---SNMMSDG---EFLRTSCGSPNY 179 + Y H ++H+DLK +NV D + I DFGL S ++ G + LR G + Sbjct: 142 GMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH 200 Query: 180 AAPEVI--------SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVF 231 APE+I +L D+++ G I Y L PF + + ++ G Sbjct: 201 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTG-- 258 Query: 232 YIPEYLN-----RSVATLLMHMLQVDPLKRATIKDIR 263 + L+ + ++ +L+ + +R T + Sbjct: 259 -MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM 294 >4EUT-A nrPDB Length = 396 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 22/237 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++L D LG G V G H+ TG A+K+ N V RE + LK H + Sbjct: 11 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 68 Query: 76 IIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 130 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 128 Query: 131 HRHMVVHRDLKPENVL--LDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + +VHR++KP N++ + K+ DFG + + D E + G+ Y P++ Sbjct: 129 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 188 Query: 187 G-------RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFY 232 + G VD+WS GV Y G+LPF + KI G Sbjct: 189 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 245 >5TE0-A nrPDB Length = 347 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 122/293 (41%), Gaps = 39/293 (13%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPH 75 + + L G F V + G K A+K + L V KREIQ ++ H + Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVC---KREIQIMRDLSGHKN 77 Query: 76 IIKLYQVISTPT------DFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAV 127 I+ + ++M++ GG++ + + + E E ++F AV Sbjct: 78 IVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAV 137 Query: 128 DYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR---------TSCGS 176 H+ ++HRDLK EN+LL + + DFG + + Sbjct: 138 ARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTT 197 Query: 177 PNYAAPEVISGRLYAGP----EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY 232 +Y APE+++ LY+G + DIW+ G +LY L TLPF + V I G F Sbjct: 198 LSYRAPEMVN--LYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA-----ICDGNFT 250 Query: 233 IPEY--LNRSVATLLMHMLQVDPLKRATIKDIREHEW--FKQDLPSYLFPEDP 281 IP+ ++ + L+ +ML+ DP KR I + + K++ P P Sbjct: 251 IPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSP 303 >2RIO-A nrPDB Length = 434 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 117/290 (40%), Gaps = 50/290 (17%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHII 77 LG G+ G V + G VAVK + +D EI+ L HP++I Sbjct: 20 EKILGYGSSGTVVF-QGSFQGRPVAVKRML------IDFCDIALMEIKLLTESDDHPNVI 72 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARR-------LFQQILSAVDYC 130 + Y +T ++ +E + L D + +E + L +QI S V + Sbjct: 73 RYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 131 HRHMVVHRDLKPENVLLD-------------AHMNAKIADFGLSNMMSDGEF-----LRT 172 H ++HRDLKP+N+L+ ++ I+DFGL + G+ L Sbjct: 132 HSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 173 SCGSPNYAAPEVISG------RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKK 225 G+ + APE++ + +DI+S G + Y +L G PF D++ Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE--SN 249 Query: 226 IRGGVFYIPE-------YLNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 I G+F + E L L+ M+ DPLKR T + H F Sbjct: 250 IIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >3MDY-A nrPDB Length = 337 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 115/299 (38%), Gaps = 51/299 (17%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 69 R + +G G +G+V +G+ + G KVAVK+ + S + EI Sbjct: 33 RTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFR----ETEIYQTV 86 Query: 70 LFRHPHIIKLYQVISTPT----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 L RH +I+ T +++ +Y G L+DY+ K ++ +L +S Sbjct: 87 LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL-KSTTLDAKSMLKLAYSSVS 145 Query: 126 AVDYCH--------RHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFL----RT 172 + + H + + HRDLK +N+L+ + IAD GL+ +SD + T Sbjct: 146 GLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNT 205 Query: 173 SCGSPNYAAPEVI-----SGRLYAGPEVDIWSCGVILYALLCG----------TLPFDD- 216 G+ Y PEV+ + D++S G+IL+ + LP+ D Sbjct: 206 RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDL 265 Query: 217 ---EHVPTLFKK---IRGGVFYIPEYLNRSVA-----TLLMHMLQVDPLKRATIKDIRE 264 + ++ I+ P + L+ +P R T +++ Sbjct: 266 VPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK 324 >6HMD-A nrPDB Length = 365 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 119/317 (37%), Gaps = 52/317 (16%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L LG G + +V + +V ++ K + + + ++NL+ Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNERV---VVKILKPVKKKKIKREVKILENLRGGT- 108 Query: 74 PHIIKLYQVISTP--TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 +IIKL + P +V EY++ + + + + + R ++L A+DYCH Sbjct: 109 -NIIKLIDTVKDPVSKTPALVFEYINNTDFKQL---YQILTDFDIRFYMYELLKALDYCH 164 Query: 132 RHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP NV++D ++ D+GL+ + S + PE++ Sbjct: 165 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQM 224 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 236 +D+WS G +L +++ PF L+ ++ + + Sbjct: 225 YDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPH 284 Query: 237 ------------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDL 272 ++ LL +L+ D +R T K+ EH +F Sbjct: 285 FNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF---Y 341 Query: 273 PSYLFPEDPSYDANVID 289 P PS D V+ Sbjct: 342 PVVKEQSQPSADNAVLS 358 >1PY5-A nrPDB Length = 326 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 116/292 (39%), Gaps = 51/292 (17%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 VL +++G G FG+V G+ + G +VAVKI + ++ RS EI + RH +I Sbjct: 32 VLQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREA----EIYQTVMLRHENI 85 Query: 77 IKLYQVISTP----TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH- 131 + + T ++V +Y G LFDY+ ++ E + L S + + H Sbjct: 86 LGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK-LALSTASGLAHLHM 144 Query: 132 -------RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD-----GEFLRTSCGSPNY 179 + + HRDLK +N+L+ + IAD GL+ G+ Y Sbjct: 145 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 204 Query: 180 AAPEVISGRLY-----AGPEVDIWSCGVILYALLCG----------TLPFDD----EHVP 220 APEV+ + + DI++ G++ + + LP+ D + Sbjct: 205 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV 264 Query: 221 TLFKKI---RGGVFYIPEYLN-----RSVATLLMHMLQVDPLKRATIKDIRE 264 +K+ + IP R +A ++ + R T I++ Sbjct: 265 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 316 >6O8B-A nrPDB Length = 665 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 22/237 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++L D LG G V G H+ TG A+K+ N V RE + LK H + Sbjct: 17 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 74 Query: 76 IIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 130 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 75 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 134 Query: 131 HRHMVVHRDLKPENVL--LDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + +VHR++KP N++ + K+ DFG + + D E G+ Y P++ Sbjct: 135 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYE 194 Query: 187 G-------RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFY 232 + G VD+WS GV Y G+LPF + KI G Sbjct: 195 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >2H34-A nrPDB Length = 309 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 112/250 (44%), Gaps = 6/250 (2%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 + G Y L +G G G V E + VA+K+++ +++RE + Sbjct: 32 QFGPYRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRL 91 Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 + PH++ ++ ++ M ++G +L + + G + A + +QI SA+D H Sbjct: 92 QEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAH 151 Query: 132 RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNYAAPEVISGRL 189 HRD+KPEN+L+ A A + DFG+++ +D + + + G+ Y APE S Sbjct: 152 AAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS-ES 210 Query: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP---EYLNRSVATLLM 246 +A DI++ +LY L G+ P+ + + + I + + + ++ Sbjct: 211 HATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIA 270 Query: 247 HMLQVDPLKR 256 + +P R Sbjct: 271 RGMAKNPEDR 280 >4MD7-E nrPDB Length = 391 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 113/296 (38%), Gaps = 49/296 (16%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L LG G + +V + KV ++ K + + + ++NL+ Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKV---VVKILKPVKKKKIKREIKILENLRGG-- 91 Query: 74 PHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+II L ++ P +V E+V+ + + + + + R +IL A+DYCH Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 148 Query: 132 RHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 149 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 208 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 236 +D+WS G +L +++ PF H L+ I + Sbjct: 209 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 268 Query: 237 ------------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 ++ L +L+ D R T ++ EH +F Sbjct: 269 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >6NT9-A nrPDB Length = 742 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 101/237 (42%), Gaps = 22/237 (9%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 ++L D LG G V G H+ TG A+K+ N V RE + LK H + Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLNHKN 66 Query: 76 IIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGR---VEEMEARRLFQQILSAVDYC 130 I+KL+ + T ++ME+ G L+ + + + E E + + ++ +++ Sbjct: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 131 HRHMVVHRDLKPENVL--LDAHMN--AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + +VHR++KP N++ + K+ DFG + + D E + G+ Y P++ Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 Query: 187 G-------RLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGGVFY 232 + G VD+WS GV Y G+LPF + KI G Sbjct: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >5L2Q-C nrPDB Length = 320 Score = 188 bits (477), Expect = 7e-48, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 127/299 (42%), Gaps = 49/299 (16%) Query: 12 KIGHYVLGDTLGVGTFGKV-----KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR--- 63 + G ++LG LG V + T +KIL ++ + + +R Sbjct: 12 RAGPFILGPRLGN---SPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGK 68 Query: 64 -----EIQNLKLFR-HPHIIKLYQVIST------------------PTDFFMVME-YVSG 98 E L L ++ + + +V++ + Sbjct: 69 MLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAH 128 Query: 99 G---------ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA 149 L Y+ K R+ E E +F ++ V+ H+ +VHRDLK N++L+ Sbjct: 129 DFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNK 188 Query: 150 HMN-AKIADFGLSNMM-SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL 207 + I +F L + S+G+ L+ GSP Y +P+V+SGR Y G D+W+ GV+L+ + Sbjct: 189 RTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTM 248 Query: 208 LCGTLPFDDEHVPTLFKKIRGGVFYIPEY--LNRSVATLLMHMLQVDPLKRATIKDIRE 264 L G PF D LF+KI+ + IPE ++ + L+ +L +DP +R D+ E Sbjct: 249 LYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >5VC6-A nrPDB Length = 289 Score = 187 bits (476), Expect = 9e-48, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 108/276 (39%), Gaps = 32/276 (11%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF-RH 73 + + +G G FG V +L G A+K + S+D RE+ + +H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVD-EQNALREVYAHAVLGQH 70 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDY 129 H+++ + + + EY +GG L D I ++ R +E E + L Q+ + Y Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 130 CHRHMVVHRDLKPENVLLDAHMNA-------------------KIADFGLSNMMSDGEFL 170 H +VH D+KP N+ + KI D G +S + Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ-- 188 Query: 171 RTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGV 230 G + A EV+ P+ DI++ + + G P + +IR G Sbjct: 189 -VEEGDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPR--NGDQWHEIRQGR 244 Query: 231 FY-IPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 IP+ L++ LL M+ DP +R + + +H Sbjct: 245 LPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >6EII-A nrPDB Length = 352 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 113/296 (38%), Gaps = 49/296 (16%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y L LG G + +V + KV ++ K + + + ++NL+ Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEKV---VVKILKPVKKKKIKREIKILENLRGG-- 114 Query: 74 PHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+II L ++ P +V E+V+ + + + + + R +IL A+DYCH Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQL---YQTLTDYDIRFYMYEILKALDYCH 171 Query: 132 RHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP NV++D H ++ D+GL+ G+ S + PE++ Sbjct: 172 SMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQM 231 Query: 191 AGPEVDIWSCGVILYALLCGTLPFDDEH--------------VPTLFKKIRGGVFYIPEY 236 +D+WS G +L +++ PF H L+ I + Sbjct: 232 YDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPR 291 Query: 237 ------------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 ++ L +L+ D R T ++ EH +F Sbjct: 292 FNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >2WO6-A nrPDB Length = 382 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 62/242 (25%), Positives = 106/242 (43%), Gaps = 20/242 (8%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 +G + Y + +G G+FG+V ++ VA+KI+ +K + + + E++ Sbjct: 48 NGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKA----FLNQAQIEVRL 103 Query: 68 LKLFR-HP-----HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRL 119 L+L H +I+ L + +V E +S L+D + V R+ Sbjct: 104 LELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKF 162 Query: 120 FQQILSAVDYCH--RHMVVHRDLKPENVLL--DAHMNAKIADFGLSNMMSDGEFLRTSCG 175 QQ+ +A+ + ++H DLKPEN+LL KI DFG S + G+ + Sbjct: 163 AQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQ 220 Query: 176 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPE 235 S Y +PEV+ G Y +D+WS G IL + G F + KI + P Sbjct: 221 SRFYRSPEVLLGMPY-DLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 279 Query: 236 YL 237 ++ Sbjct: 280 HI 281 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 14/31 (45%) Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 L++ ML DP R +H +FK+ Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFKK 378 >5XVU-A nrPDB Length = 332 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 112/299 (37%), Gaps = 51/299 (17%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y + +G G + +V G A K+ KIKREI+ L+ Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA------IKVLKPVKKKKIKREIKILQNLNG 84 Query: 74 -PHIIKLYQVISTP--TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 P+IIKL ++ P ++ EY++ + + + + + R QIL A+DYC Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILKALDYC 141 Query: 131 HRHMVVHRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL 189 H ++HRD+KP N+++D + ++ +GL+ G+ S Y PE++ Sbjct: 142 HSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQ 201 Query: 190 YAGPEVDIWSCGVILYALLCGTLP-FDDEHVPTLFKKIRG-------------------- 228 +DIWS G +L ++ P F KI Sbjct: 202 LYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKP 261 Query: 229 ------GVFYIPEY-----------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 G + + V L+ ML D KR K+ EH +F++ Sbjct: 262 HYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 >4CRL-A nrPDB Length = 406 Score = 186 bits (472), Expect = 3e-47, Method: Composition-based stats. Identities = 71/326 (21%), Positives = 122/326 (37%), Gaps = 75/326 (23%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 Y G +G GT+G V + + A+K +I + REI L+ + Sbjct: 24 EYE-GCKVGRGTYGHVYKAKRKDGKDDKDYALK-----QIEGTGISMSACREIALLRELK 77 Query: 73 HPHIIKLYQVIST--PTDFFMVMEYVSGGELFDYICKHG---------RVEEMEARRLFQ 121 HP++I L +V + +++ +Y +L+ I H ++ + L Sbjct: 78 HPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLY 136 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLL----DAHMNAKIADFGLSNMMSDGEF----LRTS 173 QIL + Y H + V+HRDLKP N+L+ KIAD G + + + L Sbjct: 137 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV 196 Query: 174 CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL-------------PFDDEHVP 220 + Y APE++ G + +DIW+ G I LL P+ + + Sbjct: 197 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLD 256 Query: 221 TLFK-------KIRGGVFYIPEY---------------------------LNRSVATLLM 246 +F K + +PE+ + LL Sbjct: 257 RIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQ 316 Query: 247 HMLQVDPLKRATIKDIREHEWFKQDL 272 +L +DP+KR T + + +F +D Sbjct: 317 KLLTMDPIKRITSEQAMQDPYFLEDP 342 >5AR8-A nrPDB Length = 326 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 103/263 (39%), Gaps = 22/263 (8%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 L G G V H +VAVK L+ + RE + L R +I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEA---RRLFQQILSAVDYCHRH-- 133 + + + P +V EY+ G L + + + ++ R+ +I V+Y H Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSN------MMSDGEFLRTSCGSPNYAAPEVIS- 186 ++H DLK +N+LLD + KIADFGLS S G+ Y PE Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 187 -GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP-TLFKKIRGG------VFYIPEYLN 238 + A + DI+S VI + +L PF+D P + + G +P + Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIP 276 Query: 239 RSVA--TLLMHMLQVDPLKRATI 259 +L+ +P +R + Sbjct: 277 HRARMISLIESGWAQNPDERPSF 299 >2PVN-A nrPDB Length = 352 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 107/298 (35%), Gaps = 49/298 (16%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 Y + +G G + +V G + K + ++ + + L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNEK-----CIIKILKPVKKKKIKREIKILQNLCGG 106 Query: 74 PHIIKLYQVI--STPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+I+KL ++ ++ EYV+ D+ + + + + R ++L A+DYCH Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNT---DFKVLYPTLTDYDIRYYIYELLKALDYCH 163 Query: 132 RHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 190 ++HRD+KP NV++D + ++ D+GL+ G+ S + PE++ Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQD 223 Query: 191 AGPEVDIWSCGVILYALLCGTLP-FDDEHVPTLFKKIRG--------------------- 228 +D+WS G + ++ P F KI Sbjct: 224 YDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQ 283 Query: 229 -----GVFYIPEYL-----------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 G +L + L +L+ D +R T + H +F+Q Sbjct: 284 LEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 >3REP-A nrPDB Length = 271 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 111/267 (41%), Gaps = 24/267 (8%) Query: 6 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 KH G + L G++ G Q G+ + VK+L + + S E Sbjct: 3 KHSG-IDFKQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVL-KVRDWSTRKSRDFNEEC 58 Query: 66 QNLKLFRHPHIIKLYQVISTPT--DFFMVMEYVSGGELFDYICKHGRV--EEMEARRLFQ 121 L++F HP+++ + +P ++ ++ G L++ + + ++ +A + Sbjct: 59 PRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFAL 118 Query: 122 QILSAVDYCH--RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCG---S 176 + + + H ++ L +V++D M A+I+ M+D +F S G + Sbjct: 119 DMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQSPGRMYA 171 Query: 177 PNYAAPEVISGRLYAG--PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFY 232 P + APE + + D+WS V+L+ L+ +PF D + K+ G Sbjct: 172 PAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPT 231 Query: 233 IPEYLNRSVATLLMHMLQVDPLKRATI 259 IP ++ V+ L+ + DP KR Sbjct: 232 IPPGISPHVSKLMKICMNEDPAKRPKF 258 >4PL5-B nrPDB Length = 435 Score = 184 bits (467), Expect = 9e-47, Method: Composition-based stats. Identities = 70/269 (26%), Positives = 118/269 (43%), Gaps = 29/269 (10%) Query: 19 GDTLGVGTFGK-VKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHI 76 D LG G G V G VAVK + + RE+Q L+ HP++ Sbjct: 32 KDVLGHGAEGTIVYKG--MFDNRDVAVKRIL------PECFSFADREVQLLRESDEHPNV 83 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE-MEARRLFQQILSAVDYCHRHMV 135 I+ + ++ +E + L +Y+ + +E L Q S + + H + Sbjct: 84 IRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNI 142 Query: 136 VHRDLKPENVLL---DAHMNAK--IADFGLSNMMSDGEFLRTSC----GSPNYAAPEVIS 186 VHRDLKP N+LL +AH K I+DFGL ++ G + G+ + APE++S Sbjct: 143 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 202 Query: 187 GRLYAGP--EVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG----VFYIPEYLNR 239 P VDI+S G + Y ++ G PF + + + G F+ ++ + Sbjct: 203 EDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDCFHSDKHEDV 261 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWF 268 L+ M+ +DP +R + K + +H +F Sbjct: 262 IARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >2JD5-A nrPDB Length = 373 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 84/361 (23%), Positives = 135/361 (37%), Gaps = 82/361 (22%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 71 K Y+L LG G F V + + + VA+KI+ K+ + EI+ L+ Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKV----YTEAAEDEIKLLQRV 72 Query: 72 RHP-----------HIIKLYQVISTPT----DFFMVMEYVSGGELFDYICK--HGRVEEM 114 HI+KL + MV E + G L I K H + + Sbjct: 73 NDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEHRGIPLI 131 Query: 115 EARRLFQQILSAVDYCHRH-MVVHRDLKPENVL---LDAHMN---AKIADFGLSNMMSDG 167 +++ +Q+L +DY HR ++H D+KPENVL +D+ N KIAD G + Sbjct: 132 YVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY--D 189 Query: 168 EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----------DDE 217 E S + Y +PEV+ G + G DIWS +++ L+ G F DD+ Sbjct: 190 EHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDD 248 Query: 218 HVPTLF--------------------------------------KKIRGGVFYIPEYLNR 239 H+ + + + + + + Sbjct: 249 HIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAK 308 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDL--PSYLFPEDPSYDANVIDDEAVKEVC 297 ++ L MLQ+DP KRA + H W K L P+ Y + +EV Sbjct: 309 EISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEEVR 368 Query: 298 E 298 + Sbjct: 369 D 369 >6HV0-A nrPDB Length = 416 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 119/269 (44%), Gaps = 29/269 (10%) Query: 19 GDTLGVGTFGK-VKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHI 76 D LG G G V G VAVK + + RE+Q L+ HP++ Sbjct: 13 KDVLGHGAEGTIVYRG--MFDNRDVAVKRIL------PECFSFADREVQLLRESDEHPNV 64 Query: 77 IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE-MEARRLFQQILSAVDYCHRHMV 135 I+ + ++ +E + L +Y+ + +E L QQ S + + H + Sbjct: 65 IRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNI 123 Query: 136 VHRDLKPENVLL---DAHMNAK--IADFGLSNMMSDGEFLRTSC----GSPNYAAPEVIS 186 VHRDLKP N+L+ +AH K I+DFGL ++ G + G+ + APE++S Sbjct: 124 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 183 Query: 187 G--RLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGG----VFYIPEYLNR 239 + VDI+S G + Y ++ G+ PF + + + G + ++ + Sbjct: 184 EDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDCLHPEKHEDV 242 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWF 268 L+ M+ +DP KR + K + +H +F Sbjct: 243 IARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >5E8V-A nrPDB Length = 316 Score = 181 bits (460), Expect = 7e-46, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 110/304 (36%), Gaps = 60/304 (19%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTG----HKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 L +G G F +V + + VAVKI ++ S I +I + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LK 67 Query: 73 HPHIIKLYQVISTPTDF----FMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD 128 H +I++ T+ +++ + + G L +Y+ +H + + R+L + + Sbjct: 68 HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRKLGSSLARGIA 126 Query: 129 YCHR---------HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-----DGEFLRTSC 174 + H +VHRDLK N+L+ + + DFGLS + D Sbjct: 127 HLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQV 186 Query: 175 GSPNYAAPEVI-----SGRLYAGPEVDIWSCGVILYALLCG----------TLPF----- 214 G+ Y APEV+ + + + D++S ++L+ + PF Sbjct: 187 GTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVR 246 Query: 215 DDEHVPTLFKKIR--GGVFYIPEYLNRS-----VATLLMHMLQVDPLKRATIKDI----- 262 + V ++ + G IP + V L DP R T + + Sbjct: 247 EHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFS 306 Query: 263 -REH 265 EH Sbjct: 307 ELEH 310 >4IAN-A nrPDB Length = 358 Score = 181 bits (459), Expect = 9e-46, Method: Composition-based stats. Identities = 74/335 (22%), Positives = 127/335 (37%), Gaps = 78/335 (23%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQ-LTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 G V Y + G G F V +VAVKI+ ++ + +E++ Sbjct: 25 GEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNEL----MQKTGLKELEF 80 Query: 68 LKLFRHP------HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR---VEEMEARR 118 LK H ++L++ +V E +S L + + K+G+ + R Sbjct: 81 LKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRS 139 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSP 177 QQ+ A+ R ++H D+KP+N+L++ K+ DFG ++ ++D + + S Sbjct: 140 YSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITPYLVSR 198 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLF------------KK 225 Y APE+I G+ Y +D+WS G LY L G + F + + K Sbjct: 199 FYRAPEIIIGKSY-DYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKM 257 Query: 226 IRGGVF---------------------------------------------YIPEYLNRS 240 IR GVF +PE + Sbjct: 258 IRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKK 317 Query: 241 V---ATLLMHMLQVDPLKRATIKDIREHEWFKQDL 272 V LL +L +DP KR +I +H + ++ + Sbjct: 318 VHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 352 >3SOC-A nrPDB Length = 322 Score = 180 bits (458), Expect = 1e-45, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 109/287 (37%), Gaps = 51/287 (17%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 L + G FG V QL VAVKI Q +S E+ +L +H +I Sbjct: 27 QLLEVKARGRFGCVWKA--QLLNEYVAVKIFPIQDKQSWQNEY----EVYSLPGMKHENI 80 Query: 77 IKLYQVISTPT----DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132 ++ T D +++ + G L D++ + V E + + + + Y H Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN-VVSWNELCHIAETMARGLAYLHE 139 Query: 133 ----------HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF---LRTSCGSPNY 179 + HRD+K +NVLL ++ A IADFGL+ G+ G+ Y Sbjct: 140 DIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 199 Query: 180 AAPEVISGRLYAGPEV----DIWSCGVILYALLCGT-----------LPFDDE-----HV 219 APEV+ G + + D+++ G++L+ L LPF++E + Sbjct: 200 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 259 Query: 220 PTLFKKI--RGGVFYIPEYLNRSV-----ATLLMHMLQVDPLKRATI 259 + + + + + +Y + + D R + Sbjct: 260 EDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >2QKW-B nrPDB Length = 321 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 67/269 (24%), Positives = 113/269 (42%), Gaps = 33/269 (12%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 80 +G G FGKV G + G KVA+K R+ S + + + EI+ L RHPH++ L Sbjct: 46 LIGHGVFGKVYKGVLR-DGAKVALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLI 101 Query: 81 QVISTPTDFFMVMEYVSGGELFDYICKHG----RVEEMEARRLFQQILSAVDYCHRHMVV 136 + ++ +Y+ G L ++ + + + + Y H ++ Sbjct: 102 GFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAII 161 Query: 137 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL---RTSCGSPNYAAPEV-ISGRLYAG 192 HRD+K N+LLD + KI DFG+S ++ + G+ Y PE I GRL Sbjct: 162 HRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL--T 219 Query: 193 PEVDIWSCGVILYALLCGT------LPFD---------DEHVPTLFKKIRGGVFY---IP 234 + D++S GV+L+ +LC LP + + H ++I P Sbjct: 220 EKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRP 279 Query: 235 EYLNRSVATLLMHMLQVDPLKRATIKDIR 263 E L R + L + R ++ D+ Sbjct: 280 ESL-RKFGDTAVKCLALSSEDRPSMGDVL 307 >5UNP-A nrPDB Length = 369 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 126/336 (37%), Gaps = 80/336 (23%) Query: 7 HDGRVKIGHYVLGDTLGVGTFGKVKIG-EHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 H G Y + TLG GTFG+V +H+ G +VA+KI+ + + EI Sbjct: 27 HVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE----KYKEAARLEI 82 Query: 66 QNLKLFR-----HPHI-IKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM--EAR 117 L+ + ++ ++++ + E + G FD++ + + + R Sbjct: 83 NVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVR 141 Query: 118 RLFQQILSAVDYCHRHMVVHRDLKPENVL-LDAHMN------------------AKIADF 158 + Q+ AV + H + + H DLKPEN+L +++ ++ DF Sbjct: 142 HMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDF 201 Query: 159 GLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH 218 G + D E T + +Y APEVI ++ P D+WS G I++ G F Sbjct: 202 GSATF--DHEHHSTIVSTRHYRAPEVILELGWSQP-CDVWSIGCIIFEYYVGFTLFQTHD 258 Query: 219 VPT---------------LFKKIRGGVFYI---------------------P--EYLNRS 240 + +K R ++ P YL Sbjct: 259 NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE 318 Query: 241 V------ATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 L+ ML+ +P KR T+ + +H +F + Sbjct: 319 AEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFAR 354 >5VDK-A nrPDB Length = 297 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 116/279 (41%), Gaps = 40/279 (14%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF-RH 73 ++ + +GVG FG V +L G A+K + + L E+ + H Sbjct: 16 EFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH----GRVEEMEARRLFQQILSAVDY 129 PH+++ Y + + EY +GG L I ++ EE + + + QI ++Y Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 130 CHRHMVVHRDLKPENV-----------------------LLDAHMNAKIADFGLSNMMSD 166 H +VH D+KP N+ L A++ KI D G + ++ Sbjct: 135 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN- 193 Query: 167 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG--TLPFDDEHVPTLFK 224 + G + A E++ P+ DI++ G+ + + G +LP + Sbjct: 194 --KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLP----TNGAAWH 246 Query: 225 KIRGGVFY-IPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 IR G F +P+ L+ S ++LL +M+Q D +R + + Sbjct: 247 HIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 285 >3RAW-A nrPDB Length = 381 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 70/338 (20%), Positives = 115/338 (34%), Gaps = 80/338 (23%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-KVAVKILNRQKIRSLDVVGKIKREIQN 67 G Y + LG GTFGKV G +VA+KI+ + EI Sbjct: 46 GDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVG----KYREAARLEINV 101 Query: 68 LKLFR---HPH---IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRL 119 LK + + + + + + E + F+++ ++ R + Sbjct: 102 LKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNT-FEFLKENNFQPYPLPHVRHM 160 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLL-------------------DAHMNAKIADFGL 160 Q+ A+ + H + + H DLKPEN+L + + ++ADFG Sbjct: 161 AYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGS 220 Query: 161 SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP 220 + D E T + +Y PEVI +A P D+WS G IL+ G F Sbjct: 221 ATF--DHEHHTTIVATRHYRPPEVILELGWAQP-CDVWSIGCILFEYYRGFTLFQTHENR 277 Query: 221 T---LFKKIRGGVF----------------------------YIPEYLNR---------- 239 + +KI G + Y+ E Sbjct: 278 EHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSL 337 Query: 240 ---SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPS 274 + L+ ML+ DP +R T+ + H +F P Sbjct: 338 EHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 375 >5XD6-A nrPDB Length = 305 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 53/215 (24%), Positives = 85/215 (39%), Gaps = 21/215 (9%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 +Y +G G++G+V G + +G A+K L+ K + ++ + R Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD----QEFLAQVSMVSRLRQ 76 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR---------VEEMEARRLFQQIL 124 +++ L + EY G L D + + + ++ Sbjct: 77 ENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAA 136 Query: 125 SAVDYCHRH---MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSPN 178 ++Y H V+HRD+K NVLL AKIADF LSN D G+ Sbjct: 137 RGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFG 196 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP 213 Y APE + + D++S GV+L LL G P Sbjct: 197 YHAPEYAMTGTLST-KSDVYSFGVVLLELLTGRKP 230 >4MWI-A nrPDB Length = 294 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 101/249 (40%), Gaps = 17/249 (6%) Query: 31 KIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHPHIIKLYQVI----ST 85 GE+ VA+K+ + + S+ +V + +EI+ +K F P+I++++ + T Sbjct: 41 YKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVT 98 Query: 86 PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH--RHMVVHRDLKPE 143 P F +VMEY G L + + + + + L + H +H ++ Sbjct: 99 PPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSS 158 Query: 144 NVLLDAHMNAKIADFGLSNM-----MSDGEFLRTSCGSPNYAAPEVISGRLY-AGPEVDI 197 N L+ K+A F L + S Y +P+ + Y + +I Sbjct: 159 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 218 Query: 198 WSCGVILYALLCGTLPFDDEHVPTLFK--KIRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 +S G++L+ + G +PF + + K ++ + E + ++ DP Sbjct: 219 YSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSV 278 Query: 256 RATIKDIRE 264 R ++ +I + Sbjct: 279 RPSVDEILK 287 >2QLU-A nrPDB Length = 314 Score = 174 bits (442), Expect = 7e-44, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 115/297 (38%), Gaps = 52/297 (17%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 G V G L + G FG V QL VAVKI Q +S +REI + Sbjct: 9 SGLVPRGSLQLLEIKARGRFGCVWKA--QLMNDFVAVKIFPLQDKQSWQS----EREIFS 62 Query: 68 LKLFRHPHIIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 +H ++++ + +++ + G L DY+ K + E + + + Sbjct: 63 TPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYL-KGNIITWNELCHVAETM 121 Query: 124 LSAVDYCHR-----------HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF--- 169 + Y H + HRD K +NVLL + + A +ADFGL+ G+ Sbjct: 122 SRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD 181 Query: 170 LRTSCGSPNYAAPEVISGRLYAGPEV----DIWSCGVILYALLCGT-----------LPF 214 G+ Y APEV+ G + + D+++ G++L+ L+ LPF Sbjct: 182 THGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPF 241 Query: 215 DDE-----HVPTLFKKI--RGGVFYIPEYL--NRSVATL---LMHMLQVDPLKRATI 259 ++E + L + + + I ++ + +A L + D R + Sbjct: 242 EEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4LFI-A nrPDB Length = 374 Score = 174 bits (442), Expect = 8e-44, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 120/337 (35%), Gaps = 79/337 (23%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAV----------------------- 44 D Y + + +G G + +V G + K+ + Sbjct: 34 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 93 Query: 45 -KILNRQKIRSLDVVGKIKREIQNLKLFR----------HPHIIKLYQVISTP--TDFFM 91 K+ D ++E LK R H +II L+ +I P + Sbjct: 94 EKVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 152 Query: 92 VMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD-AH 150 V EYV D+ + ++ ++E R ++L A+DYCH ++HRD+KP NV++D + Sbjct: 153 VFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 209 Query: 151 MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCG 210 ++ D+GL+ S + PE++ +D+WS G +L +++ Sbjct: 210 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 269 Query: 211 TLPF--DDEHVPTLFKKIR------------GGVFYIPEYL------------------- 237 PF + L K ++ +P Sbjct: 270 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 329 Query: 238 -----NRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 N + L+ ++L+ D +R T K+ H WF Sbjct: 330 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >4M66-A nrPDB Length = 325 Score = 174 bits (441), Expect = 9e-44, Method: Composition-based stats. Identities = 68/276 (24%), Positives = 114/276 (41%), Gaps = 34/276 (12%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V + +G G FG V H+ H VAVKI+N +KI E++ + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS---------WEVKAMVN 67 Query: 71 FRHPHIIKLYQVISTPTDFF-----MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 125 R+ +++ L V F +V ++ G L + RL Q+++ Sbjct: 68 LRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVL 127 Query: 126 AVDYCHR--HMVVHRDLKPENVLLDAHMNAKIADFGLSNMM-------SDGEFLRTSCGS 176 + Y H ++HRDLKP N+LLD ++AK+ADFGLS G R S G+ Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGT 187 Query: 177 PNYAAPEVISG-RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI--RGGVFYI 233 Y PE++ L A D++S G++++A+L G + + + + R + Sbjct: 188 LAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPL 247 Query: 234 PEYLN--------RSVATLLMHMLQVDPLKRATIKD 261 E + L++H R + +D Sbjct: 248 TELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >4BTF-A nrPDB Length = 469 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 101/250 (40%), Gaps = 15/250 (6%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVG-KIKREIQNLKLFRHPHIIKLYQVIST- 85 + GE+ + V +K+ N + S+ +V EI+ +K F P+I++++ + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 86 ---PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 P +F +VMEY G L + + + + L + + H +HR++ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 326 Query: 143 ENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRL-YAGPEVD 196 + L+ K+A F LS + S + Y +PE + + + Sbjct: 327 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 386 Query: 197 IWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP--EYLNRSVATLLMHMLQVDPL 254 I+S G++L+ + G +PF+ + + + P + + ++ +P Sbjct: 387 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 446 Query: 255 KRATIKDIRE 264 +R ++ I E Sbjct: 447 QRPSVDGILE 456 >4M69-B nrPDB Length = 283 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 101/250 (40%), Gaps = 15/250 (6%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVG-KIKREIQNLKLFRHPHIIKLYQVIST- 85 + GE+ + V +K+ N + S+ +V EI+ +K F P+I++++ + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 86 ---PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKP 142 P +F +VMEY G L + + + + L + + H +HR++ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISS 140 Query: 143 ENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----YAAPEVISGRL-YAGPEVD 196 + L+ K+A F LS + S + Y +PE + + + Sbjct: 141 SSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAE 200 Query: 197 IWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP--EYLNRSVATLLMHMLQVDPL 254 I+S G++L+ + G +PF+ + + + P + + ++ +P Sbjct: 201 IYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 260 Query: 255 KRATIKDIRE 264 +R ++ I E Sbjct: 261 QRPSVDGILE 270 >3VHK-A nrPDB Length = 368 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 7/164 (4%) Query: 108 HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSD 166 + Q+ +++ +HRDL N+LL KI DFGL+ + D Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 253 Query: 167 GEFLR--TSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF 223 +++R + + APE I R+Y + D+WS GV+L+ + G P+ + F Sbjct: 254 PDYVRKGDARLPLKWMAPETIFDRVYT-IQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 312 Query: 224 -KKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 ++++ G P+Y + ++ +P +R T ++ EH Sbjct: 313 CRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 79.6 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 39/109 (35%), Gaps = 9/109 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIG-----EHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 LG LG G FG+V + T VAVK+L S + Sbjct: 24 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEH--RALMS 81 Query: 64 EIQNLKLFRHP-HIIKLYQVISTP-TDFFMVMEYVSGGELFDYICKHGR 110 E++ L H +++ L + P +++E+ G L Y+ Sbjct: 82 ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRN 130 >5USZ-A nrPDB Length = 289 Score = 169 bits (429), Expect = 3e-42, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 111/287 (38%), Gaps = 30/287 (10%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGH-------KVAVKILNRQKIRSLDVVGKIK 62 +++ + ++LG GTF K+ G + G +V +K+L++ + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAH---RNYSESFF 60 Query: 63 REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQ 121 + H H++ Y V + +V E+V G L Y+ K+ + + + + Sbjct: 61 EAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAK 120 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMN--------AKIADFGLSNMMSDGEFLRTS 173 Q+ +A+ + + ++H ++ +N+LL + K++D G+S + + L+ Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 174 CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFY 232 + PE I D WS G L+ + G P + Sbjct: 181 I---PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ-FYEDRHQ 236 Query: 233 IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPE 279 +P +A L+ + + +P R + + I +DL S P+ Sbjct: 237 LPAPKAAELANLINNCMDYEPDHRPSFRAII------RDLNSLFTPD 277 >3G2F-A nrPDB Length = 336 Score = 169 bits (429), Expect = 3e-42, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 114/308 (37%), Gaps = 62/308 (20%) Query: 8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN 67 + + + + L + +G G +G V G L VAVK+ + ++ I R Sbjct: 7 EPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYR---- 60 Query: 68 LKLFRHPHIIKLY----QVISTPT-DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122 + L H +I + +V + ++ +VMEY G L Y+ H + + + RL Sbjct: 61 VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DWVSSCRLAHS 119 Query: 123 ILSAVDYCH---------RHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR-- 171 + + Y H + + HRDL NVL+ I+DFGLS ++ +R Sbjct: 120 VTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPG 179 Query: 172 -------TSCGSPNYAAPEVISGRLY------AGPEVDIWSCGVILYALLCGTL-PFDDE 217 + G+ Y APEV+ G + A +VD+++ G+I + + F E Sbjct: 180 EEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGE 239 Query: 218 HVPT-------------LFKKI------RGGVFYIPEYLNR------SVATLLMHMLQVD 252 VP F+ + PE S+ + D Sbjct: 240 SVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQD 299 Query: 253 PLKRATIK 260 R T + Sbjct: 300 AEARLTAQ 307 >3LLT-A nrPDB Length = 360 Score = 168 bits (425), Expect = 7e-42, Method: Composition-based stats. Identities = 67/336 (19%), Positives = 124/336 (36%), Gaps = 80/336 (23%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN--RQKIRSLDVVGKIKREIQ 66 G + +++ +G GTFG+V + +H AVK++ ++ RS + I ++IQ Sbjct: 30 GMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQ 89 Query: 67 NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQIL 124 N + +I+K + ++ E + G L++ I ++ + + +IL Sbjct: 90 NDDINN-NNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEIL 147 Query: 125 SAVDYCHRHMVVHRDLKPENVLLDAHM-------------------------NAKIADFG 159 A++Y + + H DLKPEN+LLD K+ DFG Sbjct: 148 KALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFG 207 Query: 160 LSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV 219 + SD + + + Y APEVI + D+WS G +L L G+L F Sbjct: 208 CATFKSD--YHGSIINTRQYRAPEVILNLGW-DVSSDMWSFGCVLAELYTGSLLFRTHEH 264 Query: 220 PTLFKKIRGGVFYIPEYL------------------------------------------ 237 + + IP+ + Sbjct: 265 MEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLY 324 Query: 238 ----NRSVATLLMHMLQVDPLKRATIKDIREHEWFK 269 + L +LQ+DP R + ++ +H++ + Sbjct: 325 KIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3HNG-A nrPDB Length = 360 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 7/163 (4%) Query: 108 HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG 167 + + Q+ +++ +HRDL N+LL + KI DFGL+ + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 168 EFLRTSCGSP---NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLF 223 + + APE I ++Y+ + D+WS GV+L+ + G P+ + F Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKIYST-KSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 224 -KKIRGG-VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 ++R G PEY + +++ DP +R ++ E Sbjct: 312 CSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVE 354 Score = 80.4 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 41/110 (37%), Gaps = 9/110 (8%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIG-----EHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 LG +LG G FGKV + T VAVK+L S + Sbjct: 22 WEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATAS--EYKALMT 79 Query: 64 EIQNLKLFRHP-HIIKLYQVIST-PTDFFMVMEYVSGGELFDYICKHGRV 111 E++ L H +++ L + +++EY G L +Y+ + Sbjct: 80 ELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 129 >6BFN-A nrPDB Length = 342 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 49/209 (23%), Positives = 81/209 (38%), Gaps = 20/209 (9%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHPHIIKL 79 +G G FG V + T AVK L V + E++ L FRHP+I+ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 80 YQVISTPTDFFMVMEYVSGGELFDYICKHGR----VEEMEARRLFQQILSAVDYCH--RH 133 + + +V ++ G L D + + + + + A+ + H Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNM-----MSDGE-----FLRTSCGSPNYAAPE 183 ++H D+K NVLLD + K+ DFGL+ S + +T G+ Y PE Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PE 205 Query: 184 VISGRLYAGPEVDIWSCGVILYALLCGTL 212 + D +S GV++ L G Sbjct: 206 EYIKTGRLAVDTDTFSFGVVVLETLAGQR 234 >3QD2-B nrPDB Length = 332 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 67/331 (20%), Positives = 114/331 (34%), Gaps = 77/331 (23%) Query: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKIL---NRQKIRSLDVVG---------- 59 + + +G G FG V ++++ A+K + NR+ R + Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 64 Query: 60 ---------------KIKRE---------------------------IQNLKLFRHPHII 77 K + E I+ + F + + Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 78 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME---ARRLFQQILSAVDYCHRHM 134 Q S ++ M+ L D++ + +E+ E +F QI AV++ H Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKG 184 Query: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-------------FLRTSCGSPNYAA 181 ++HRDLKP N+ K+ DFGL M E G+ Y + Sbjct: 185 LMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 182 PEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY--IPEYLNR 239 PE I G Y+ +VDI+S G+IL+ LL + +R F + + Sbjct: 245 PEQIHGNNYSH-KVDIFSLGLILFELLYSFS--TQMERVRIITDVRNLKFPLLFTQKYPQ 301 Query: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 ++ ML P +R DI E+ F+ Sbjct: 302 E-HMMVQDMLSPSPTERPEATDIIENAIFEN 331 >4F9B-A nrPDB Length = 361 Score = 164 bits (415), Expect = 9e-41, Method: Composition-based stats. Identities = 66/344 (19%), Positives = 108/344 (31%), Gaps = 97/344 (28%) Query: 16 YVLGDTLGVGTFGKVKIGEHQL---TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 72 + + D +G GTF V + QL K+A+K L +I E+Q L + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL-----IPTSHPIRIAAELQCLTVAG 77 Query: 73 -HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 +++ + + M Y+ D + + E R + A+ H Sbjct: 78 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL---NSLSFQEVREYMLNLFKALKRIH 134 Query: 132 RHMVVHRDLKPENVLLDAHMNAK-IADFGLSNMMSDG----------------------- 167 + +VHRD+KP N L + + + DFGL+ D Sbjct: 135 QFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCS 194 Query: 168 ------EFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF----DDE 217 + + G+P + APEV++ +D+WS GVI +LL G PF DD Sbjct: 195 ICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDL 254 Query: 218 HVPTLFKKIRGGVFYIPE--------YLNRS--VATLLMHM------------------- 248 IRG I ++ L Sbjct: 255 TALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQG 314 Query: 249 -------LQ---------------VDPLKRATIKDIREHEWFKQ 270 ++P R T ++ H +FK Sbjct: 315 HATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >4L00-A nrPDB Length = 304 Score = 158 bits (399), Expect = 7e-39, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 104/272 (38%), Gaps = 20/272 (7%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIG------EHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 R+ V G+ LG GT + G + + T + +K++ + S + Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF 80 Query: 64 EI-QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVEEMEARRLFQ 121 E ++ H HI+ LY V + MV E+V GG L ++ + + ++ + Sbjct: 81 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAK 140 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMN-------AKIADFGLSNMMSDGEFLRTSC 174 Q+ SA+ Y +VH ++ +N+LL K++D G+ + + Sbjct: 141 QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI 200 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYI 233 + APE + D WS G L+ + G +P D+ + + + Sbjct: 201 ---PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPV 257 Query: 234 PEYLNRSVATLLMHMLQVDPLKRATIKDIREH 265 + +A L+ + DP +R + I Sbjct: 258 TPSC-KELADLMTRCMNYDPNQRPFFRAIMRD 288 >4EAL-A nrPDB Length = 106 Score = 155 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 71/153 (46%), Positives = 82/153 (53%), Gaps = 52/153 (33%) Query: 400 AKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYL 459 AKWHLGIRSQS+P DIMAEV RA+KQLD+EWKVVN Y+LRVRRKNPVT + KMSLQLY Sbjct: 6 AKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQ 65 Query: 460 VDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGS 519 VD+R+YLLDF S D Sbjct: 66 VDSRTYLLDF------------------------------RSIDDGGGGGGG-------- 87 Query: 520 LTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 552 SHT++FFEMCA+LI LA+ Sbjct: 88 --------------SHTIEFFEMCANLIKILAQ 106 >2X7G-A nrPDB Length = 389 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 67/371 (18%), Positives = 115/371 (30%), Gaps = 118/371 (31%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G + G Y + LG G F V + VA+K++ + EI+ L Sbjct: 26 GDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQ----HYTETALDEIKLL 81 Query: 69 KLFR-----HPH---IIKLYQVISTPT----DFFMVMEYVSGGELFDYICK--HGRVEEM 114 K R P+ +++L MV E + L +I K + + Sbjct: 82 KCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH-HLLKWIIKSNYQGLPVR 140 Query: 115 EARRLFQQILSAVDYCHRH-MVVHRDLKPENVLL-------------------------- 147 + + +Q+L +DY H ++H D+KPEN+L+ Sbjct: 141 CVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPS 200 Query: 148 ---------------------DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 + KIAD G + + + + Y + EV+ Sbjct: 201 GSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWV--HKHFTEDIQTRQYRSIEVLI 258 Query: 187 GRLYAGPEVDIWSCGVILYALLCGTLPF----------DDEHVPTLFKKI--------RG 228 G Y+ P DIWS + + L G F D++H+ + + + Sbjct: 259 GAGYSTP-ADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALS 317 Query: 229 GVFYI------------------------------PEYLNRSVATLLMHMLQVDPLKRAT 258 G + P L+ ML++ P KRA+ Sbjct: 318 GKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRAS 377 Query: 259 IKDIREHEWFK 269 + H W Sbjct: 378 AGECLRHPWLN 388 >4WUA-A nrPDB Length = 401 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 69/373 (18%), Positives = 116/373 (31%), Gaps = 120/373 (32%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G + G Y + LG G F V + VA+K++ + EI+ L Sbjct: 36 GDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK----SAEHYTETALDEIRLL 91 Query: 69 KLFRH--PH------IIKLYQVIS----TPTDFFMVMEYVSGGELFDYICK--HGRVEEM 114 K R+ P+ +++L T MV E + L +I K + + Sbjct: 92 KSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH-HLLKWIIKSNYQGLPLP 150 Query: 115 EARRLFQQILSAVDYCHRH-MVVHRDLKPENVLLD------------------------- 148 +++ QQ+L +DY H ++H D+KPEN+LL Sbjct: 151 CVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPS 210 Query: 149 ------------------------AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 + KIAD G + + + + Y + EV Sbjct: 211 GSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWV--HKHFTEDIQTRQYRSLEV 268 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPF----------DDEHVPTLFKKIRG------ 228 + G Y P DIWS + + L G F D++H+ + + + Sbjct: 269 LIGSGYNTP-ADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLI 327 Query: 229 --------------------------------GVFYIPEYLNRSVATLLMHMLQVDPLKR 256 + + L+ ML++ P KR Sbjct: 328 VAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKR 387 Query: 257 ATIKDIREHEWFK 269 AT + H W Sbjct: 388 ATAAECLRHPWLN 400 >4RT7-A nrPDB Length = 415 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 42/207 (20%), Positives = 76/207 (36%), Gaps = 15/207 (7%) Query: 63 REIQNLKLFRHPHIIKLYQ-VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 RE+Q I L+ + + EY + + + + Sbjct: 198 REVQIHP--DSDQISGLHGNSFHSEDEI----EY-ENQKRLEEEEDLNVLTFEDLLCFAY 250 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSP---N 178 Q+ +++ VHRDL NVL+ KI DFGL+ + + Sbjct: 251 QVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVK 310 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKIRGGVFYI--PE 235 + APE + +Y + D+WS G++L+ + G P+ V F K+ F + P Sbjct: 311 WMAPESLFEGIYT-IKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPF 369 Query: 236 YLNRSVATLLMHMLQVDPLKRATIKDI 262 Y + ++ D KR + ++ Sbjct: 370 YATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 46/120 (38%), Gaps = 8/120 (6%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEH---QLTGH--KVAVKILNRQKIRSLDVVGKIKR 63 + G LG G FGKV TG +VAVK+L + S + Sbjct: 60 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS--EREALMS 117 Query: 64 EIQNLKLF-RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQ 122 E++ + H +I+ L + +++ EY G+L +Y+ +F++ Sbjct: 118 ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE 177 >3SV0-A nrPDB Length = 483 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 56/230 (24%), Positives = 101/230 (43%), Gaps = 25/230 (10%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFR 72 + LG +G G+FG++ +G + T +VA+K+ N + K L KI R +Q Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGI- 65 Query: 73 HPHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 P+ ++ + V +VM+ + S +LF++ + ++ L Q+++ V++ Sbjct: 66 -PN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSR--KLSLKTVLMLADQMINRVEFV 119 Query: 131 HRHMVVHRDLKPENVLLDAHM---NAKIADFGLSNMMSDGEFL--------RTSCGSPNY 179 H +HRD+KP+N L+ I DFGL+ D + G+ Y Sbjct: 120 HSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARY 179 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV---PTLFKKI 226 A+ G + D+ S G +L L G+LP+ ++KI Sbjct: 180 ASVNTHLG-IEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKI 228 >5FQD-C nrPDB Length = 341 Score = 151 bits (382), Expect = 7e-37, Method: Composition-based stats. Identities = 58/241 (24%), Positives = 98/241 (40%), Gaps = 31/241 (12%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 G Y L +G G+FG + + + G +VAVK L QK R ++ E + K+ + Sbjct: 19 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKARHP----QLLYESKLYKILQG 73 Query: 74 ----PHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAV 127 PHI + Y +VM+ + S +LF++ + R L Q++S + Sbjct: 74 GVGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVLMLADQMISRI 128 Query: 128 DYCHRHMVVHRDLKPENVLLDAHMNAK---IADFGLSNMMSDGEFL--------RTSCGS 176 +Y H +HRD+KP+N L+ + + DFGL+ D + G+ Sbjct: 129 EYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGT 188 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV---PTLFKKIRGGVFYI 233 YA+ G + D+ S G +L +LP+ ++KI Sbjct: 189 ARYASINAHLG-IEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMST 247 Query: 234 P 234 P Sbjct: 248 P 248 >5X18-A nrPDB Length = 295 Score = 150 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 105/253 (41%), Gaps = 33/253 (13%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 73 HY +G +G G+FG + G + + G VA+K R+ +++ E + K+ Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKT-----EAPQLRDEYKTYKILNGT 62 Query: 74 PHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 P+I Y +V++ + S +LFD+ + + ++ Q+++ ++ H Sbjct: 63 PNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGR--KFSVKTVVQVAVQMITLIEDLH 120 Query: 132 RHMVVHRDLKPENVLLDAHM-----NAKIADFGLSNMMSDGEF--------LRTSCGSPN 178 H +++RD+KP+N L+ N + DFG++ D + ++ G+ Sbjct: 121 AHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTAR 180 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVP---TLFKKIRGGVFYIPE 235 Y + GR D+ + G + + L G LP+ P ++KI Sbjct: 181 YMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR---- 235 Query: 236 YLNRSVATLLMHM 248 + +V L + Sbjct: 236 --STNVYDLAQGL 246 >2CMW-A nrPDB Length = 310 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 106/254 (41%), Gaps = 31/254 (12%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFRHPH 75 +G +G G FG++++G++ T VA+K+ + + L + + +++ + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAG----EG 58 Query: 76 IIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133 + ++Y MV+E + S +LFD + + Q+LS ++Y H Sbjct: 59 LPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 134 MVVHRDLKPENVLLDAHMNAK-----IADFGLSNMMSDGEFL--------RTSCGSPNYA 180 +++RD+KPEN L+ N K I DFGL+ D E ++ G+ Y Sbjct: 117 NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM 176 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL---FKKIRGGVFYIP--- 234 + G+ D+ + G + L G+LP+ TL ++KI P Sbjct: 177 SINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEA 235 Query: 235 --EYLNRSVATLLM 246 E +AT L Sbjct: 236 LCENFPEEMATYLR 249 >4TN6-A nrPDB Length = 318 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 58/238 (24%), Positives = 96/238 (40%), Gaps = 25/238 (10%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKI-LNRQKIRSLDVVGKIKREIQNLKLFR 72 Y LG +G G+FG + +G G +VA+K+ + K L + KI + +Q Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVG-- 64 Query: 73 HPHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 I + + MVME + S +LF++ + + L Q++S ++Y Sbjct: 65 ---IPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSR--KFSLKTVLLLADQMISRIEYI 119 Query: 131 HRHMVVHRDLKPENVL--LDAHMN-AKIADFGLSNMMSDGEFL--------RTSCGSPNY 179 H +HRD+KP+N L L N I DFGL+ D + G+ Y Sbjct: 120 HSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV---PTLFKKIRGGVFYIP 234 A+ G + D+ S G +L G+LP+ +++I P Sbjct: 180 ASINTHLG-IEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 >5X1R-A nrPDB Length = 302 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 48/283 (16%), Positives = 104/283 (36%), Gaps = 35/283 (12%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDV-------------- 57 + + + + +G G FG V +A+K + + Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKT 78 Query: 58 ----VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH-GRVE 112 + +E + L F HP ++ + + +M ++ SG L + + +++ Sbjct: 79 FQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKID 138 Query: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN-MMSDGEFLR 171 E RRL + SA++ H+ +HRD+ +N+ + + DFG + + + Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDET 198 Query: 172 TSCGSPNYAAPEVI--SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG 229 P +A E + GP DI++ G +L+ L+ G+ P ++ + I Sbjct: 199 EIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSIEDS 253 Query: 230 VFYI----PEYLNRSVATLLMHMLQVDPLKRAT----IKDIRE 264 + P + + + L + P R + ++ E Sbjct: 254 YQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >2CHL-A nrPDB Length = 351 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 100/239 (41%), Gaps = 27/239 (11%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFRH 73 ++ +G +G G FG++++G++ T VA+K+ + + L + + + +L Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYK-----QLGSG 85 Query: 74 PHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 I ++Y MV+E + S +LFD + + Q++S ++Y H Sbjct: 86 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFSLKTVLMIAIQLISRMEYVH 143 Query: 132 RHMVVHRDLKPENVLLDAHMN-----AKIADFGLSNMMSDGEFL--------RTSCGSPN 178 +++RD+KPEN L+ N I DF L+ D E ++ G+ Sbjct: 144 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTAR 203 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL---FKKIRGGVFYIP 234 Y + G+ D+ + G + L G+LP+ TL ++KI P Sbjct: 204 YMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 261 >2C47-A nrPDB Length = 313 Score = 148 bits (375), Expect = 4e-36, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 105/256 (41%), Gaps = 32/256 (12%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFRH 73 ++ +G +G G FG++++G++ T VA+K+ + + L + + +++ Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSAT----- 59 Query: 74 PHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 + ++Y MV+E + S +LFD + + Q+++ ++Y H Sbjct: 60 EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLITRMEYVH 117 Query: 132 RHMVVHRDLKPENVLLDAHMN-----AKIADFGLSNMMSDGEFL--------RTSCGSPN 178 +++RD+KPEN L+ I DFGL+ D E ++ G+ Sbjct: 118 TKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 177 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL---FKKIRGGVFYIP- 234 Y + G+ D+ + G + L G+LP+ TL ++KI P Sbjct: 178 YMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 236 Query: 235 ----EYLNRSVATLLM 246 E +AT L Sbjct: 237 EVLCENFPEEMATYLR 252 >2PZI-A nrPDB Length = 681 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 67/270 (24%), Positives = 109/270 (40%), Gaps = 36/270 (13%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ-LTGHKVAVKILNRQKIRSLDVVGKIKR 63 Q + G + G Y + + G G + + + + G V +K L + +R Sbjct: 71 QLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER 130 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDF-----FMVMEYVSGGELFDYICKHGRVEEMEARR 118 Q L HP I++++ + ++VMEYV G L K ++ EA Sbjct: 131 --QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIA 186 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178 +IL A+ Y H +V+ DLKPEN++L K+ D G + ++ +L G+P Sbjct: 187 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY---GTPG 242 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY--IPEY 236 + APE++ DI++ G L A L LP R G + +PE Sbjct: 243 FQAPEIVRTGP--TVATDIYTVGRTLAA-LTLDLP------------TRNGRYVDGLPED 287 Query: 237 LN-----RSVATLLMHMLQVDPLKRATIKD 261 S LL + DP +R T + Sbjct: 288 DPVLKTYDSYGRLLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 67/270 (24%), Positives = 109/270 (40%), Gaps = 36/270 (13%) Query: 5 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ-LTGHKVAVKILNRQKIRSLDVVGKIKR 63 Q + G + G Y + + G G + + + + G V +K L + +R Sbjct: 110 QLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER 169 Query: 64 EIQNLKLFRHPHIIKLYQVISTPTDF-----FMVMEYVSGGELFDYICKHGRVEEMEARR 118 Q L HP I++++ + ++VMEYV G L K ++ EA Sbjct: 170 --QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIA 225 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178 +IL A+ Y H +V+ DLKPEN++L K+ D G + ++ +L G+P Sbjct: 226 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY---GTPG 281 Query: 179 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY--IPEY 236 + APE++ DI++ G L A L LP R G + +PE Sbjct: 282 FQAPEIVRTGP--TVATDIYTVGRTLAA-LTLDLP------------TRNGRYVDGLPED 326 Query: 237 LN-----RSVATLLMHMLQVDPLKRATIKD 261 S LL + DP +R T + Sbjct: 327 DPVLKTYDSYGRLLRRAIDPDPRQRFTTAE 356 >5M07-A nrPDB Length = 276 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 102/270 (37%), Gaps = 40/270 (14%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKL 70 V Y + LG G+V + +H A+K+L+ + + +RE + Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEMEARRLFQQILSAVD 128 HPHI++++ ++ M+YV G + ++ + E + + A+D Sbjct: 87 LFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 129 YCHRHMVVHRDLKPENVLLDA----HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 Y H+ ++HRD+ P NV+L + +ADFG+++ P+Y APE+ Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPEL 193 Query: 185 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN---RSV 241 +G G D ++ + L G P D H L P L+ + Sbjct: 194 SAGADVDG-RADQYALALTAIHLFAGAPPVDRSHTGPL----------QPPKLSAFRPDL 242 Query: 242 ATL---LMHMLQVDPLKRAT----IKDIRE 264 A L L L P R D Sbjct: 243 ARLDGVLSRALATAPADRFGSCREFADAMN 272 >5J0A-A nrPDB Length = 300 Score = 144 bits (364), Expect = 8e-35, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 97/284 (34%), Gaps = 38/284 (13%) Query: 18 LGDTLGVGTFGKVKIGEHQLTG---HKVAVKILNR---QKIRSLDVVGKIKREIQNLKLF 71 LG GT V + + G AVK +N RS+ ++ E + LK Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSV-YQKRLMDEAKILKSL 71 Query: 72 RHPHIIKLYQVIS-TPTDFFMVMEYVSGGELFDYICKH-----GRVEEMEARRLFQQILS 125 HP+I+ + MEY L D I + ++ + Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 126 AVDYCH-RHMVVHRDLKPENVLLDAHM-NAKIADFGLSNMMSDGEFLRT----SCGSPNY 179 + Y H ++H D+K NV++ KI D G+S + + + G+ + Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP--------------FDDEH-VPTLFK 224 E + + DI++ G+ L+ ++ ++P FD+ + Sbjct: 192 KPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYY 251 Query: 225 KIRGGVFYIP-EYLNRS---VATLLMHMLQVDPLKRATIKDIRE 264 G I E L+ S V L DP R + I E Sbjct: 252 AALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >4BTK-A nrPDB Length = 337 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 51/229 (22%), Positives = 87/229 (37%), Gaps = 21/229 (9%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + + +G G FG++ LT VA+K+ + Q+ + + +K E+ LK + Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV-----LKMEVAVLKKLQG 110 Query: 74 P-HIIKLYQVISTPTDFFMVMEYVSGGELFDYICK--HGRVEEMEARRLFQQILSAVDYC 130 H+ + ++VM+ G L D G RL +QIL +++ Sbjct: 111 KDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 169 Query: 131 HRHMVVHRDLKPENV----LLDAHMNAKIADFGLSNMMS-------DGEFLRTSCGSPNY 179 H +HRD+KP N L + + DFGL+ + + G+ Y Sbjct: 170 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 229 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG 228 A+ R G D+WS +L G LP+ I+ Sbjct: 230 ASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >4NFN-A nrPDB Length = 309 Score = 142 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 51/229 (22%), Positives = 87/229 (37%), Gaps = 21/229 (9%) Query: 14 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 73 + + +G G FG++ LT VA+K+ + Q+ + + +K E+ LK + Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQV-----LKMEVAVLKKLQG 75 Query: 74 P-HIIKLYQVISTPTDFFMVMEYVSGGELFDYICK--HGRVEEMEARRLFQQILSAVDYC 130 H+ + ++VM+ G L D G RL +QIL +++ Sbjct: 76 KDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 134 Query: 131 HRHMVVHRDLKPENV----LLDAHMNAKIADFGLSNMMS-------DGEFLRTSCGSPNY 179 H +HRD+KP N L + + DFGL+ + + G+ Y Sbjct: 135 HSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRY 194 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRG 228 A+ R G D+WS +L G LP+ I+ Sbjct: 195 ASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >4NT4-A nrPDB Length = 312 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 103/240 (42%), Gaps = 23/240 (9%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQNLKLFRH 73 ++ +G +G G FG++++G++ VA+K+ + K L + + + + + Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAP 72 Query: 74 PHIIKLYQVISTPTDFF-MVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 I ++Y + + + MV+E + S +LF+ + + + +Q+L ++Y Sbjct: 73 DGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICAR--KFSLKTVLMIAKQLLHRIEYV 130 Query: 131 HRHMVVHRDLKPENVLLDAHMN-----AKIADFGLSNMMSDGEF--------LRTSCGSP 177 H +++RD+KPEN L+ I DFGL+ D + ++ G+ Sbjct: 131 HSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTA 190 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTL---FKKIRGGVFYIP 234 Y + GR D+ + G + L G+LP+ TL ++KI P Sbjct: 191 RYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 249 >4I94-A nrPDB Length = 300 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 90/240 (37%), Gaps = 21/240 (8%) Query: 29 KVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD 88 V G+ ++AVK NR+ S + E + + R+ + L + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRK---SWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 89 FFMVMEYVSGGELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRHM-VVHRDLKPENV 145 ++ E++ L ++ + ++ R+ I A++YC ++ DL V Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 146 LLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205 L D N +++ FGL DG+ T+ + PE + PE I+S G +L Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYSTN---LAFTPPEYLR-TGRVTPESVIYSFGTLLL 215 Query: 206 ALLCGT--LPFD------DEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRA 257 LL G P D ++ L G F + + L LQ +P +R Sbjct: 216 DLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGT--ELIRLASRCLQYEPRERP 273 >4L68-A nrPDB Length = 340 Score = 138 bits (347), Expect = 8e-33, Method: Composition-based stats. Identities = 45/192 (23%), Positives = 82/192 (42%), Gaps = 15/192 (7%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPT 87 G G +AVK L+ K+ + + E+ L RH ++ L Sbjct: 54 GTTYKA-LLPDGSALAVKHLSTCKLGERE----FRYEMNQLWELRHSNLAPLLGFCVVEE 108 Query: 88 DFFMVMEYVSGGELFDYI-CKHGRVEEMEARRLFQQILSAVDYCH---RHMVVHRDLKPE 143 + F+V +Y+S G L + G ++ R+ + + H R ++H+++ Sbjct: 109 EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSS 168 Query: 144 NVLLDAHMNAKIADFGLSNMM-----SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 +L+D +A+I D GL+ +M ++ F+ G Y APE S + A + D++ Sbjct: 169 VILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASLKGDVY 227 Query: 199 SCGVILYALLCG 210 GV+L L G Sbjct: 228 GLGVVLLELATG 239 >5C01-A nrPDB Length = 342 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 86/243 (35%), Gaps = 17/243 (6%) Query: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMV 92 G + +V +K+L+ D+ + H H+ ++ V + MV Sbjct: 101 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 157 Query: 93 MEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL---- 147 EYV G L ++ + G V + QQ+ SA+ Y +VH ++ N+LL Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 217 Query: 148 ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-GPEVDIWSCGVI 203 K++D G+ E + APE + G + +D W G Sbjct: 218 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 274 Query: 204 LYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 L + G P + +PE +ATL L +P +R + + I Sbjct: 275 LLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTI 333 Query: 263 REH 265 Sbjct: 334 LRD 336 >4WOV-A nrPDB Length = 317 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 86/243 (35%), Gaps = 17/243 (6%) Query: 33 GEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMV 92 G + +V +K+L+ D+ + H H+ ++ V + MV Sbjct: 78 GRDRGQELRVVLKVLDPSHH---DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 134 Query: 93 MEYVSGGELFDYICK-HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL---- 147 EYV G L ++ + G V + QQ+ SA+ Y +VH ++ N+LL Sbjct: 135 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 194 Query: 148 ---DAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-GPEVDIWSCGVI 203 K++D G+ E + APE + G + +D W G Sbjct: 195 LAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGAT 251 Query: 204 LYALLC-GTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 L + G P + +PE +ATL L +P +R + + I Sbjct: 252 LLEICFDGEAPLQSRSPSE-KEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTI 310 Query: 263 REH 265 Sbjct: 311 LRD 313 >1CSN-A nrPDB Length = 298 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 93/238 (39%), Gaps = 25/238 (10%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF-RH 73 HY +G +G G+FG + G + L +VA+K R+ +++ E + KL Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR-----SDAPQLRDEYRTYKLLAGC 65 Query: 74 PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHR 132 I +Y +V++ + G L D + GR +Q+L+ V H Sbjct: 66 TGIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHE 124 Query: 133 HMVVHRDLKPENVLLDAHMN-----AKIADFGLSNMMSDGEF--------LRTSCGSPNY 179 +V+RD+KP+N L+ + + DFG+ D + G+ Y Sbjct: 125 KSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARY 184 Query: 180 AAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDE---HVPTLFKKIRGGVFYIP 234 + GR + + D+ + G + L G+LP+ +++I P Sbjct: 185 MSINTHLGREQSRRD-DLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTP 241 >4XHH-A nrPDB Length = 403 Score = 132 bits (333), Expect = 3e-31, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 107/274 (39%), Gaps = 35/274 (12%) Query: 10 RVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 +++G + +G +G G+FG + G + ++G +VA+ + IRS ++ E + Sbjct: 2 DLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRH--PQLDYESRVY 56 Query: 69 KLFRHPHIIKLYQVISTPTDFF-MVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILS 125 K I + ++ MV++ + S +LF+Y H + L Q++ Sbjct: 57 KYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC--HRKFSFKTVIMLALQMIC 114 Query: 126 AVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLR--------TSC 174 V Y H +HRD+KP+N L+ + DFGLS D R + Sbjct: 115 RVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLT 174 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHV---PTLFKKIRGGVF 231 G+ YA+ G + D+ S G +L G+LP+ + +I Sbjct: 175 GTARYASVNTHLG-IEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKL 233 Query: 232 YIP-----EYLNRSVATLLMHM--LQVDPLKRAT 258 I L + + + L+ D +R Sbjct: 234 CISVETLCAGLPLEFSEYMNYCRNLKFD--ERPD 265 >4XHL-A nrPDB Length = 394 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 98/231 (42%), Gaps = 23/231 (9%) Query: 10 RVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILN-RQKIRSLDVVGKIKREIQN 67 +++G + +G +G G+FG + G + ++G +VA+++ + R + LD ++ R + Sbjct: 2 DLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSG 61 Query: 68 LKLFRHPHIIKLYQVISTPTDFFMVMEYV--SGGELFDYICKHGRVEEMEARRLFQQILS 125 P I + + MV++ + S +LF+Y H R L Q+ Sbjct: 62 GVGI--PFI-RWFG--REGEYNAMVIDLLGPSLEDLFNYC--HRRFSFKTVIMLALQMFC 114 Query: 126 AVDYCHRHMVVHRDLKPENVLLD---AHMNAKIADFGLSNMMSDGEFLR--------TSC 174 + Y H +HRD+KP+N L+ + DFGLS D R + Sbjct: 115 RIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLT 174 Query: 175 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 G+ YA+ G + D+ S G +L G+LP+ T +K Sbjct: 175 GTARYASVNTHLG-IEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQK 224 >5UV4-A nrPDB Length = 311 Score = 129 bits (324), Expect = 4e-30, Method: Composition-based stats. Identities = 46/205 (22%), Positives = 86/205 (41%), Gaps = 16/205 (7%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 79 + +G G G+ + VK L +S + REI+ L RHP+++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK---KEFSREIKKLGSVRHPNLVPL 86 Query: 80 YQVISTPT--DFFMVMEYVSGGELFDYICKHG-----RVEEMEARRLFQQILSAVDYCHR 132 P + M+ +Y L Y+ + + + + I +DY H Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 133 HMVV-HRDLKPENVLL-DAHMNAKIADFGLSNMMSDGEFLRT--SCGSPNYAAPE-VISG 187 V+ H ++K NVL+ ++ +A + D+ L +M+ + G+ Y+ PE + Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 188 RLYAGPEVDIWSCGVILYALLCGTL 212 + + D+++ GVIL LL G + Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGKI 231 >5OAT-A nrPDB Length = 411 Score = 128 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 114/309 (36%), Gaps = 64/309 (20%) Query: 11 VKIGHYVLGDTLGVGTFGKVKIGEHQLT-----GHKVAVKILNRQKIR--SLDVVGKIKR 63 + + LG + GT G V + + + A+K++ I+ S++++ + R Sbjct: 8 ITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYR 67 Query: 64 E-----------------IQNLKLFRH----PHIIKLYQVIST----------------- 85 E I+ +H P+I+ ++ V + Sbjct: 68 ETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGR 127 Query: 86 PTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENV 145 F++M+ L ++ + L Q+L V + H + HRDLK +N+ Sbjct: 128 NMSLFLLMKRYDC-NLQSFLST--APSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNL 184 Query: 146 LLD----AHMNAKIADFG--LSNM-----MSDGEFLRTSCGSPNYAAPEVISGRLYAGP- 193 LLD I+DFG L++ + + G+ APE+I + Sbjct: 185 LLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSV 244 Query: 194 ----EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHML 249 + D+W+ G I Y + PF F G + +P+ + + L+ ++L Sbjct: 245 LNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLL 304 Query: 250 QVDPLKRAT 258 + +P KR Sbjct: 305 KRNPNKRLD 313 >6EAS-A nrPDB Length = 308 Score = 125 bits (313), Expect = 7e-29, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 96/242 (39%), Gaps = 35/242 (14%) Query: 42 VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF--FMVMEYVSGG 99 VA ++ K S + + +++I NL H + + L F MV EY G Sbjct: 69 VASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNG 128 Query: 100 ELFDYIC--KHGRVEEMEARRLFQQILSAVDYCHRH--MVVHRDLKPENVLLDAHMNAKI 155 LF+++ + +++ M R+ I +++ H+ R+ V L AK+ Sbjct: 129 TLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKV 188 Query: 156 ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVD--IWSCGVILYALLCGTLP 213 +D EF + G + + L P+++ + G++L +L G +P Sbjct: 189 SDL---------EFWNDAKGHNS-----TTNNELAFSPDMEDIVRKYGMVLLEILTGRVP 234 Query: 214 FDDEHVP-------------TLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 ++ P L + I + + PE R++ ++ + DP KR +K Sbjct: 235 SSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMK 294 Query: 261 DI 262 ++ Sbjct: 295 EV 296 >4JRN-A nrPDB Length = 372 Score = 116 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 93/286 (32%), Gaps = 47/286 (16%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR--------- 72 LG G F V T ++AVK+ +K + + + ++RE + F Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 73 --HPHIIK---------------LYQVISTPTDFFMVMEYVSGGELFDYIC--------K 107 ++ + + + + ++ + ++ I Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 108 HGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDG 167 + L Q + V +VH D+KP N LL + DFG + Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI---N 252 Query: 168 EFLRTSCGSPNYAAPE---VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK 224 + + G+P Y PE +G Y P D W G+ LY + C P ++ Sbjct: 253 NSVGRAIGTPGYEPPERPFQATGITYTFP-TDAWQLGITLYCIWCKERP---TPADGIWD 308 Query: 225 KIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + P V L+ +L DP KR E FK+ Sbjct: 309 YLHFA--DCP-STPELVQDLIRSLLNRDPQKRMLPLQALETAAFKE 351 >6J6I-B nrPDB Length = 351 Score = 116 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 76/184 (41%), Gaps = 14/184 (7%) Query: 42 VAVKILNRQKIR-SLDVVGKIKREIQN-LKLFRHPHIIKLYQVISTPTDFFMVMEYVSGG 99 +K + +I V ++ +I ++ H + ++L +V E+ G Sbjct: 84 YMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHG 143 Query: 100 ELFDY---IC--KHGRVEEMEARRLFQQILSAVDYCHR---HMVVHRDLKPENVLLDAHM 151 + I + + ++ ++I +AV Y H +++HRD+KP +V LD + Sbjct: 144 AMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNW 203 Query: 152 NAKIADFGLSNMMSDGEF---LRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL 208 AK++D S + +G+ G+ Y P + + D++S G+ L ++ Sbjct: 204 TAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVII 262 Query: 209 CGTL 212 G Sbjct: 263 TGKP 266 >6EQI-C nrPDB Length = 433 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 117/320 (36%), Gaps = 74/320 (23%) Query: 12 KIGHYVLGDTLGVGTFGKVKIGEHQLTG-----HKVAVKILNRQKIRSLD--VVGKIKRE 64 + LG+ + G V + + H++AVK++ + S ++ + RE Sbjct: 13 NLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRE 72 Query: 65 ---------------IQNLKLFR-----HPHIIKLYQVISTPTD---------------- 88 I+N+ F+ HP+I+++Y V + Sbjct: 73 TVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPR 132 Query: 89 -----------FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVH 137 F+VM+ L +Y+ + L Q+L AV + + H + H Sbjct: 133 INPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNISH 190 Query: 138 RDLKPENVLL-----DAHMNAKIADFGLS-------NMMSDGEFLRTSCGSPNYAAPEVI 185 RDLK +N+L+ DA+ I DFG ++ + G+ APE+ Sbjct: 191 RDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 186 SGRLYAG-----PEVDIWSCGVILYALLCGTLPFDDEHVPTLFK-KIRGGVFYIPEYLNR 239 + + + D+W+ G I Y + PF D+ + L K + +P+ + Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDTIPF 310 Query: 240 SVATLLMHMLQVDPLKRATI 259 + L+ +ML KR Sbjct: 311 IIRNLVSNMLSRSTNKRLDC 330 >5UU1-A nrPDB Length = 324 Score = 94.6 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 49/234 (20%), Positives = 88/234 (37%), Gaps = 33/234 (14%) Query: 10 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVA---VKILNRQKIRSLDVVGKIKR--- 63 ++ +VLG +G G FG + + K A VK+ ++ + +R Sbjct: 12 DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAK 71 Query: 64 --------EIQNLKLFRHPHIIKLYQV----ISTPTDFFMVMEYVSGGELFDYICKHGRV 111 E + L I Y + FMVME + G +L ++G Sbjct: 72 KDCIKKWIERKQLDYLG---IPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTF 127 Query: 112 EEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEF 169 ++ +L ++L ++Y H + VH D+K N+LL +AD+GLS Sbjct: 128 KKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGN 187 Query: 170 LRTS--------CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 + G+ + + + G + D+ G + LCG LP++ Sbjct: 188 HKQYQENPRKGHNGTIEFTSLDAHKG-VALSRRSDVEILGYCMLRWLCGKLPWE 240 >4O1O-A nrPDB Length = 717 Score = 93.9 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 55/314 (17%), Positives = 117/314 (37%), Gaps = 57/314 (18%) Query: 9 GRVKI---GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 65 G++KI Y + DT G + +G ++ +VAVK + R ++E+ Sbjct: 342 GKLKIFIDEEYKIADT-AEGG---IYLGLYED--QEVAVKRFSEGSTRG-------QQEV 388 Query: 66 QNLKLFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG-----RVEEMEARRL 119 L+ R + +++ Y S + + + L +++ H E+ AR + Sbjct: 389 SCLQSSRANDNVVTFYGSESDGSCLHVCLALCEY-TLQEHLANHRGDAVPNEEDESARNI 447 Query: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNY 179 + A+ HR H+DL+P+N+L+D+ +ADF S ++ Sbjct: 448 LSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQK--------- 498 Query: 180 AAPEVISGRLYAGPEVDIWSCGV-ILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLN 238 + D+ + G+ +LY + G + F+ + + I+G + Sbjct: 499 -------------IKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQG-------SPD 538 Query: 239 RSVATLLMHMLQV--DPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEV 296 L+ H+ + R + + H +F Y D ++++ + Sbjct: 539 EETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRI 596 Query: 297 CEKFECTESEVMNS 310 + + SE+ S Sbjct: 597 LQLLQPGTSELSTS 610 >5CLR-A nrPDB Length = 451 Score = 92.7 bits (229), Expect = 4e-19, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 107/309 (34%), Gaps = 33/309 (10%) Query: 31 KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTD-- 88 G +K + + + + E L +L Sbjct: 96 FKVYALDDGKTYFLKSVK----IDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 89 FFMVMEYVSGGELFDY---ICKHGRVEE-MEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 +++ ++ G +L Y + + ++ E + + V H ++HRDLKP N Sbjct: 147 HYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGN 206 Query: 145 VLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE--VDIWSCGV 202 ++LDA M + DFG S+ SD E S G+ +Y APE+ + + D+++ Sbjct: 207 IMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 203 ILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKR-ATIKD 261 L L PF + I+ + L+ + + ++ + R Sbjct: 265 SLDELFN---PFRQVKFAKVDIGIKNKHLVL---LHAEIEACITGLMSNETSVRTLYFSR 318 Query: 262 IREHEWFKQDLPSYLF-PEDPSYDANVIDDEAVKEVCEKFECTESEVMNSL---YSGDPQ 317 I + ++ S+ PE +Y ++ + E++ + Y Q Sbjct: 319 ILQ---LQRVPESFKSRPEAFTYLIMLLTQWKSCYEAPEMNKELDEIIAEIKVAYENHEQ 375 Query: 318 DQLAVAYHL 326 D + + L Sbjct: 376 DAVKIITLL 384 >2LAV-A nrPDB Length = 361 Score = 86.9 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 91/270 (33%), Gaps = 41/270 (15%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHK-----VAVKILNRQKIRSLDVVGKIKREIQ--- 66 + +G +G G FG + + + + VK+ + +R + Sbjct: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95 Query: 67 -----NLKLFRHPHIIKLYQVISTPT----DFFMVMEYVSGGELFDYICKH--GRVEEME 115 + ++ + K + FM+M+ G I + R Sbjct: 96 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAKRFSRKT 153 Query: 116 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTS 173 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 Query: 174 C--------GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 G+ + + + +G + D+ G + L G LP++D + + Sbjct: 214 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 272 Query: 226 IRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 + ++A+L+ P K Sbjct: 273 DSKIRYR------ENIASLMDKCF---PEK 293 >2RSV-A nrPDB Length = 403 Score = 86.9 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 91/270 (33%), Gaps = 41/270 (15%) Query: 15 HYVLGDTLGVGTFGKVKIGEHQLTGHK-----VAVKILNRQKIRSLDVVGKIKREIQ--- 66 + +G +G G FG + + + + VK+ + +R + Sbjct: 43 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 102 Query: 67 -----NLKLFRHPHIIKLYQVISTPT----DFFMVMEYVSGGELFDYICKH--GRVEEME 115 + ++ + K + FM+M+ G I + R Sbjct: 103 IQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYEANAKRFSRKT 160 Query: 116 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD--AHMNAKIADFGLSNMMSDGEFLRTS 173 +L +IL ++Y H H VH D+K N+LL+ + D+GL+ + Sbjct: 161 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 220 Query: 174 C--------GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKK 225 G+ + + + +G + D+ G + L G LP++D + + Sbjct: 221 KEDPKRCHDGTIEFTSIDAHNG-VAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVR 279 Query: 226 IRGGVFYIPEYLNRSVATLLMHMLQVDPLK 255 + ++A+L+ P K Sbjct: 280 DSKIRYR------ENIASLMDKCF---PEK 300 >4IX6-A nrPDB Length = 350 Score = 79.6 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 51/321 (15%), Positives = 96/321 (29%), Gaps = 84/321 (26%) Query: 22 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH----II 77 LG G FG V G + V L K + ++ E+ H + Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTCA 82 Query: 78 KLYQVIS----TPTDFF--MVME---YV---SGGELFDYICKHGRVEEMEA--------- 116 + I + + + E + G + + + G A Sbjct: 83 RFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATEL 142 Query: 117 ---RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH--MNAKIADFGLSNM-MSDGEFL 170 ++ +++L ++ H VVHRD+KP N++ K+ D G + + + E L Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETL 202 Query: 171 RTSCG----SPNY--------AAP--------------EVISGRLYAGPEVDIWSCGVIL 204 G P Y P E + D WS G ++ Sbjct: 203 NYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRF-----DSWSAGCVM 257 Query: 205 YALLC-------GTLPFDDEHVP-----TLFKKIRGGVFYIPEYLNRSV-----ATLLMH 247 L G F ++ F+ + G + ++ L Sbjct: 258 LQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQR 317 Query: 248 MLQVDPLKRATIKDIREHEWF 268 +++ + RA+ + H +F Sbjct: 318 LMEAERDARASCEAALSHAFF 338 >5DMZ-A nrPDB Length = 365 Score = 78.5 bits (192), Expect = 7e-15, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 83/255 (32%), Gaps = 42/255 (16%) Query: 21 TLGVGTFGKVKIGE-----HQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75 LG G F +V K +K+ + ++ ++ +H Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLK--PSMQHMF 129 Query: 76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM-----EARRLFQQILSAVDYC 130 +K Y +V E S G L + I + E ++L ++ Sbjct: 130 -MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQV 188 Query: 131 HRHMVVHRDLKPENVLL-----------DAHMNAKIADFGLS---NMMSDGEFLRTSCGS 176 H ++H D+KP+N +L D + D G S + G C + Sbjct: 189 HDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCET 248 Query: 177 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI-PE 235 + E++S + + ++D + +Y +L G + K++ PE Sbjct: 249 SGFQCVEMLSNKPW-NYQIDYFGVAATVYCMLFG-----------TYMKVKNEGGECKPE 296 Query: 236 YLNRSVATLLMHMLQ 250 L R + L M Sbjct: 297 GLFRRLPHL--DMWN 309 >4OAU-C nrPDB Length = 699 Score = 78.5 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 50/255 (19%), Positives = 92/255 (36%), Gaps = 45/255 (17%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR-HPHIIKLYQVISTP 86 G + +G + +VAVK + + +RE+ L+ R + H++ Y S Sbjct: 357 GGIYLGFY--EKQEVAVKTF-------CEGSPRAQREVSCLQSSRENSHLVTFYGSESHR 407 Query: 87 TDFFMVMEYVS--GGELFDYICKHGRVEEME--ARRLFQQILSAVDYCH-RHMVVHRDLK 141 F+ + D E + AR + I AV H H+DL+ Sbjct: 408 GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 467 Query: 142 PENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCG 201 P+N+L+D+ A +ADF + G P EV + D+ G Sbjct: 468 PQNILIDSKKAAHLADF---------DKSIKWAGDPQ----EV---------KRDLEDLG 505 Query: 202 -VILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIK 260 ++LY + G++ F+D + + ++ + L+ + R + Sbjct: 506 RLVLYVVKKGSISFEDLKAQSNEEVVQL-------SPDEETKDLIHRLFHPGEHVRDCLS 558 Query: 261 DIREHEWFKQDLPSY 275 D+ H +F Y Sbjct: 559 DLLGHPFFWTWESRY 573 >6G4J-A nrPDB Length = 315 Score = 73.4 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 47/208 (22%), Positives = 74/208 (35%), Gaps = 28/208 (13%) Query: 9 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNL 68 G+ Y L LG G G V + E GH VA+K+ D I E+ L Sbjct: 21 GKWNGNTYTLRKQLGKGANGIVYLAE-TSDGH-VALKV--------SDDSLSITSEVNVL 70 Query: 69 KLFRHPHIIKLYQVISTPTDFFM----------VMEYVSGGELFDYICKHGRVEEMEARR 118 K F + + D ++ MEY+ G L Y+ G Sbjct: 71 KSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPV 127 Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTSCGSP 177 L Q+LS++ H+ + DLKP+N+++ + D G + T Sbjct: 128 LMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDR 187 Query: 178 NYAAPEVISGRLYAGPEVDIWSCGVILY 205 Y G A P D+++ +I+ Sbjct: 188 GYWG----YGTRKAEPSYDLFAVAMIMI 211 >6EWX-A nrPDB Length = 484 Score = 72.3 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 40/231 (17%), Positives = 74/231 (32%), Gaps = 52/231 (22%) Query: 84 STPTDFFMVMEYVSGGELFDYICK-------HGRVEEMEARRLFQQILSAVDYCHRHMVV 136 ++ V D++ V E L Q+ + +++ H ++ Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 137 HRDLKPENVLL--------------------DAHMNAK---------------------I 155 HRDL EN+LL + + I Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 156 ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD 215 ++F + G S APE++S Y + D + G+++Y LL PF+ Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFE 350 Query: 216 DEHVPTLFKKIRGGVFYIP--EYLNRSVATLLMHMLQVDPLKRATIKDIRE 264 R + +P + + L +L+ DP+KR I + + Sbjct: 351 VRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401 >5GZ9-A nrPDB Length = 305 Score = 70.0 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 48/276 (17%), Positives = 94/276 (34%), Gaps = 62/276 (22%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 +G G +V + E + HKVA+ L R L++ +Q LK + H++ Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVALSRLTR-----LEMKEDFLHGLQMLKSLQSEHVVT 91 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDY-----ICKHGRV-EEMEARRLFQQILSAVDYCHR 132 L ++ EY G L + + K+ V +L + +S ++Y H Sbjct: 92 LVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHH 149 Query: 133 HMVVHRDLKPEN--------VLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----YA 180 + R + N LL ++ + D ++ + CG + Sbjct: 150 SPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFV 209 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNR- 239 APE + W G PF D+ +P+ +K+ ++ IP+ + Sbjct: 210 APEQL------------WPYG--------EDTPFQDDLMPSYNEKV--DIWKIPDVSSFL 247 Query: 240 ------------SVATLLMHMLQVDPLKRATIKDIR 263 + + P +R T +++ Sbjct: 248 LGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVL 283 >4CI6-B nrPDB Length = 643 Score = 70.0 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 52/270 (19%), Positives = 99/270 (36%), Gaps = 49/270 (18%) Query: 36 QLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF-----RHPHIIKLYQ--VISTPTD 88 + VA KI G + E++ K +HP++ ++ V+ Sbjct: 66 KDKQRLVA-------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNR 118 Query: 89 FF--MVMEYVSG-------GELFDYICKHGRVEEM---EARRLFQQILSAVDYCHRHMVV 136 ++ ++M+ V G L D + E + + ++L ++ + +V Sbjct: 119 YYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIV 178 Query: 137 HRDLKPENVLLD-AHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV 195 H D+KP NV+ D A + D GL GE + + ++ APE+ G L A + Sbjct: 179 HNDIKPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKS 234 Query: 196 DIWSCGVILYALLCGTLPFDDEHVPTLFKKIR-------------GGVFYIPEYLNRSVA 242 D++ +++ LL G F+ + + +R G + P A Sbjct: 235 DVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETA 291 Query: 243 --TLLMHMLQVDPLKRATIKDIREHEWFKQ 270 + +L V R + R HE+ Sbjct: 292 YTRFITDILGVSADSRPDSNEARLHEFLSD 321 >5GZA-A nrPDB Length = 290 Score = 69.2 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 46/279 (16%), Positives = 80/279 (28%), Gaps = 69/279 (24%) Query: 19 GDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 78 +G G KV + E Q G KVA+ +L+ S + L+ + H++ Sbjct: 30 VKLIGQGAVKKVYLSEWQ--GQKVALSVLS-----SDQYADDFLHGLSMLRALQSSHVVT 82 Query: 79 LYQVISTPTDFFMVMEYVSGGELFDYICK------HGRVEEMEARRLFQQILSAVDYCHR 132 L V V EY G + R +L ++ + Y H Sbjct: 83 LVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 133 HMVVHRDLKPEN--------VLLDAHMNAKIADFGLSNMMS-----DGEFLRTSCG---- 175 R + N LL + M L+N + + L CG Sbjct: 141 SPAGIRVMCDSNDLHKTLSQFLLASDMRL------LANDLDALPEVEKGGLGVKCGHHEL 194 Query: 176 SPNYAAPEVI-----------SGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK 224 + ++ APE + + DIW D L Sbjct: 195 TGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIWKI--------------PDVTRFLLGD 240 Query: 225 KIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIR 263 + G V + + + + + R T +++ Sbjct: 241 VLGGDVIHF------HLFQIYSECKRKEAHMRPTAREVL 273 >6BHC-A nrPDB Length = 438 Score = 67.7 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 42/192 (21%), Positives = 76/192 (39%), Gaps = 35/192 (18%) Query: 101 LFDYICKHGRVE---EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL---------- 147 + D + +HG+ E + L Q+ S +++ + V H DL+ EN+LL Sbjct: 162 VRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQ 221 Query: 148 -----------DAHMNAKIADFGLSNM---MSDGEFLRTSCGSPNYAAPEVISGRLYAGP 193 +++F + + D E LR APE+I+ Y Sbjct: 222 GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR----LAPEIITATQY--K 275 Query: 194 EVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY--LNRSVATLLMHMLQV 251 + D + G+++Y +L PFD+ + R + IP +R + L +L Sbjct: 276 KCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNP 335 Query: 252 DPLKRATIKDIR 263 +P +R I D + Sbjct: 336 NPSERILISDAK 347 >2EHB-D nrPDB Length = 143 Score = 64.2 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 39/119 (32%), Gaps = 27/119 (22%) Query: 315 DPQDQLAVAYHLI-----------IDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGL 363 D + A+ +I D R+ + +++ PS + A+ G Sbjct: 1 DEGPLMMNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMGF 60 Query: 364 KPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRA 422 K H + L+ L++ K LAV + + P M +V +A Sbjct: 61 KSHTRNF----------KTRLEGLSSIKAGQLAVVIEIYEVA------PSLFMVDVRKA 103 >5VE6-A nrPDB Length = 492 Score = 63.8 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 37/206 (17%), Positives = 66/206 (32%), Gaps = 57/206 (27%) Query: 113 EMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAK------------------ 154 E L Q+ + +++ H ++HRDL EN LL H + Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLEN-LLLVHCTLQAGPGPAPAPAPAPAAAAP 265 Query: 155 ----------------------------------IADFGLSNMMSDGEFLRTSCGSPNYA 180 I++F + G S Sbjct: 266 PCSSAAPPAGGTLSPAAGPASPEGPREKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARL 325 Query: 181 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP--EYLN 238 APE++S Y + D + G+++Y LL PF+ + + +P + Sbjct: 326 APEIVSASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLRERDYRQEDLPPLPALSLYS 383 Query: 239 RSVATLLMHMLQVDPLKRATIKDIRE 264 + L +L+ DP+KR I + + Sbjct: 384 PGLQQLAHLLLEADPIKRIRIGEAKR 409 >6M7Z-A nrPDB Length = 319 Score = 62.3 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 32/187 (17%), Positives = 67/187 (35%), Gaps = 22/187 (11%) Query: 92 VMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHM 151 + +S G + D + + + L +++A+ H ++HR ++ + + Sbjct: 124 IFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 152 NAKIADFGLSNMMSDGEFLRTSCGSPN-YAAPEV--------ISGRLYAGPEVDIWSCGV 202 + GL G R G APE+ + + D++S GV Sbjct: 182 TVVLG--GLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 Query: 203 ILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262 L+ L + P +R + + L+ M++ +P R TI++I Sbjct: 240 AFRNLV--QLLGNGNLGPEDRGAVRQDHLELLDKLS-------QKMIEEEPGNRPTIEEI 290 Query: 263 REHEWFK 269 + F+ Sbjct: 291 MKDPLFE 297 >2JII-A nrPDB Length = 352 Score = 60.7 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 60/148 (40%), Gaps = 18/148 (12%) Query: 83 ISTPTDFFMVMEYVSGGELFDYI--CKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140 + F+V+ + G L + + E ++ ++L A+++ H + VH ++ Sbjct: 127 VHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNV 185 Query: 141 KPENVLLD--AHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAP-----EVISGRLYAG 192 EN+ +D +A +G + G+ + GS +P E IS L+ G Sbjct: 186 TAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGS---RSPHEGDLEFISMDLHKG 242 Query: 193 ----PEVDIWSCGVILYALLCGTLPFDD 216 D+ S G + L G LP+ + Sbjct: 243 CGPSRRSDLQSLGYCMLKWLYGFLPWTN 270 >4AZW-A nrPDB Length = 471 Score = 60.4 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 51/132 (38%), Gaps = 17/132 (12%) Query: 39 GHKVAVKILNRQ-------KIRSLDVVGKIKREIQNLKL----FRHPHIIKLYQVISTPT 87 G K S ++ EI+ L F P + Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAP---AVLAHGENAQ 315 Query: 88 DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL 147 ++VME + G L D + EE++ ++ +L ++ + H D++P NV++ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMV 372 Query: 148 DAHMNAKIADFG 159 DA +A++ DFG Sbjct: 373 DARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 59.6 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 51/132 (38%), Gaps = 17/132 (12%) Query: 39 GHKVAVKILNRQ-------KIRSLDVVGKIKREIQNLKL----FRHPHIIKLYQVISTPT 87 G K S ++ EI+ L F P + Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAP---AVLAHGENAQ 315 Query: 88 DFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL 147 ++VME + G L D + EE++ ++ +L ++ + H D++P NV++ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAG---EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMV 372 Query: 148 DAHMNAKIADFG 159 DA +A++ DFG Sbjct: 373 DARQHARLIDFG 384 >4CYJ-A nrPDB Length = 438 Score = 55.3 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 21/144 (14%), Positives = 53/144 (36%), Gaps = 23/144 (15%) Query: 30 VKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIST---- 85 V ++ G A++ L ++ + I +++ K ++ I+ +++V +T Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTN---EKAILNVMKDWKKIKNASIVTIHEVFTTREFG 127 Query: 86 PTDFFMVMEYVSGGELFDYICKHGR-------------VEEMEARRLFQQILSAVDYCHR 132 + ++ L + +H V E QI +A+ H Sbjct: 128 DSSLIFAYDFHP---LSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 133 HMVVHRDLKPENVLLDAHMNAKIA 156 + + R L+P ++L +++ Sbjct: 185 NRLAARCLEPSKIILTDINRIRLS 208 >3BYV-A nrPDB Length = 377 Score = 54.2 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 39/183 (21%), Positives = 70/183 (38%), Gaps = 17/183 (9%) Query: 98 GGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIAD 157 G L + H + +L Q++ + H + +VH L+P +++LD + Sbjct: 190 GEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT- 248 Query: 158 FGLSNMMSDGEFLRTSCGSPNYAAPEV------ISG----RLYAGPEVDIWSCGVILYAL 207 G +++ DG + +S S + PE+ IS R D W+ G+++Y + Sbjct: 249 -GFEHLVRDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWI 306 Query: 208 LCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEW 267 C LP + + I IP+ V LL L+ R E Sbjct: 307 WCADLPITKDAALGGSEWIFRSCKNIPQ----PVRALLEGFLRYPKEDRLLPLQAMETPE 362 Query: 268 FKQ 270 ++Q Sbjct: 363 YEQ 365 >4CZY-B nrPDB Length = 429 Score = 52.6 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 17/141 (12%), Positives = 52/141 (36%), Gaps = 19/141 (13%) Query: 31 KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIST----P 86 ++ G A++ + ++ + + + +E K + +I+ +++ +T Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 87 TDFFMVMEYVSG-GELFDY----------ICKHGRVEEMEARRLFQQILSAVDYCHRHMV 135 + V ++ L+D+ + ++ E QI +A+ H + Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 136 VHRDLKPENVLLDAHMNAKIA 156 R L+ + + + ++A Sbjct: 178 AARCLELSKI-IWENNRIRLA 197 >3DZO-A nrPDB Length = 413 Score = 52.3 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 38/182 (20%), Positives = 68/182 (37%), Gaps = 16/182 (8%) Query: 98 GGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIAD 157 G L + H + +L Q++ + H + +VH L+P +++LD + Sbjct: 195 GEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT- 253 Query: 158 FGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL---------YAGPEVDIWSCGVILYALL 208 G +++ DG + G +A PE + R+ D W+ G+ +Y + Sbjct: 254 -GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIW 311 Query: 209 CGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF 268 C LP D+ + I IP+ V LL L+ R E + Sbjct: 312 CADLPNTDDAALGGSEWIFRSCKNIPQ----PVRALLEGFLRYPKEDRLLPLQAMETPEY 367 Query: 269 KQ 270 +Q Sbjct: 368 EQ 369 >2W1Z-A nrPDB Length = 368 Score = 51.9 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 33/166 (19%), Positives = 63/166 (37%), Gaps = 16/166 (9%) Query: 101 LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGL 160 L + H + +L Q++ + +VH D + N+LLD + G Sbjct: 178 LLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT--GF 235 Query: 161 SNMMSDGEFLRTSCGSPNYAAPEVISGRL----YAGPEV-----DIWSCGVILYALLCGT 211 +++ DG + G +A PE + R+ P + D W+ G+ +Y + C Sbjct: 236 EHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCAD 294 Query: 212 LPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRA 257 LP ++ + I + + + + V LL L+ R Sbjct: 295 LPNTEDAELGGIEWI----YRRCKNIPQPVRALLEGFLRYSKEDRL 336 >3ENH-A nrPDB Length = 540 Score = 51.5 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 34/158 (21%), Positives = 56/158 (35%), Gaps = 27/158 (17%) Query: 21 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK-----REIQNLKLFRH-- 73 +G G +K V +K ++ R + I+ RE + L L + Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 74 ---PHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 130 P+I + V M Y++G D I + + +I V Sbjct: 401 IPAPYI---FDVDLDNKRIM--MSYINGKLAKDVIEDN--------LDIAYKIGEIVGKL 447 Query: 131 HRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 168 H++ V+H DL N + D I DFGL + + E Sbjct: 448 HKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDE 483 >4BWP-A nrPDB Length = 448 Score = 50.7 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 23/166 (13%), Positives = 55/166 (33%), Gaps = 43/166 (25%) Query: 31 KIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIST----P 86 H TG+K ++ ++ +++S + ++ K +H ++++L +V +T Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL----VEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 87 TDFFMVMEYVSG-----------------------GELFDYICKHGR--------VEEME 115 +V +Y G GE + K + E Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 116 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMN----AKIAD 157 + Q+ + + H + + L P +++ I+D Sbjct: 183 IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4WWA-A nrPDB Length = 261 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 53/155 (34%), Gaps = 32/155 (20%) Query: 31 KIGEHQLTGHKVAVKILNRQKIRSLDVVG-----KIKREIQNLKLFRHPHII------KL 79 + + + K +K ++ R + + E + L ++I +L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 80 YQVISTPTDFFMVM--EYVSGG----ELFDYICKHGR-----VEEMEARRLFQQILSAVD 128 ++ E + GG L +++ H + + R++ +QI + Sbjct: 95 IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL- 151 Query: 129 YCHRHMVVHRDLKPENVLLDAHM---NAKIADFGL 160 H + H DL N++L + DFGL Sbjct: 152 -LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >6G38-A nrPDB Length = 357 Score = 45.3 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 54/172 (31%), Gaps = 50/172 (29%) Query: 20 DTLGVGTFGKVKIGEHQLTGHKVAVKIL-----------NRQKIRSLDVVGKIKREIQNL 68 + +G G FG+V T VA+KI+ +++ + I +E+ L Sbjct: 47 EKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLL 104 Query: 69 KL-----------FRHPHIIK------LYQV----------------ISTPTDFFMVMEY 95 H ++ L + F+V+E+ Sbjct: 105 SGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEF 164 Query: 96 VSGG-ELFDYICKHGRVEEMEARRLFQQILSAVDYCH-RHMVVHRDLKPENV 145 GG +L + A+ + Q+ +++ HRDL NV Sbjct: 165 EFGGIDLEQ--MRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >3Q60-A nrPDB Length = 371 Score = 41.9 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 32/163 (19%), Positives = 53/163 (32%), Gaps = 14/163 (8%) Query: 119 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178 L Q++ +VH P+N+ + + D +S + G S Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVGTRGPASSVPVT 256 Query: 179 YAAPEVISGRLYAGPEV-DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY- 236 YA E ++ + W G+ +Y + C LPF P + + +P Sbjct: 257 YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF-GLVTPGIKGSWKRPSLRVPGTD 315 Query: 237 ---------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270 L V TL+ L D +R + E F Q Sbjct: 316 SLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >1TQM-A nrPDB Length = 282 Score = 41.9 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 58/157 (36%), Gaps = 30/157 (19%) Query: 18 LGDTLGVGT-----------FGKVKIGEHQLTGHKVAVKILNRQKIR-----SLDVVGKI 61 +G +G G FG+ + H++ K + ++ S+ + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSA 151 Query: 62 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ 121 + E + L+ + + K+Y ++ME + EL+ ++ + + + Sbjct: 152 RNEFRALQKLQGLAVPKVYAW----EGNAVLMELIDAKELYRVRVEN---PDEVLDMILE 204 Query: 122 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADF 158 ++ + H +VH DL NVL+ I DF Sbjct: 205 EVAK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >5YK0-A nrPDB Length = 452 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 50/177 (28%), Gaps = 56/177 (31%) Query: 28 GKVKIGEHQLTGHKVAVKILNRQKIRSLD-VVGKIKREIQNLKLF--------------- 71 G+V G +VAVKI +L + ++R + LK Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 72 -----------------------RHP-----HIIKLYQVISTPTDFFMVMEYVSGGELFD 103 HP H++ ++ E++ G + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVA-------SAPKVVIQEWIEGVPMAE 257 Query: 104 YICKHGRVEEMEARRLFQQI-LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFG 159 I + L ++ A ++H D P N +L I DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELTFDAPRRL---GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4BVU-A nrPDB Length = 211 Score = 39.6 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 44/139 (31%), Gaps = 22/139 (15%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHI 76 +LG +G G+ ++ + + + D++G EI + Sbjct: 43 ILGKLIGQGSTAEIFEDVNDSS-----------ALYKKYDLIGNQYNEILEMAWQESELF 91 Query: 77 IKLYQ-----VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH 131 Y VI D ++ M V G L D + + Q I + Sbjct: 92 NAFYGDEASVVIQYGGDVYLRMLRVPGTPLSD--IDTADIPDNIESLYLQLICK----LN 145 Query: 132 RHMVVHRDLKPENVLLDAH 150 ++H DL N+L D Sbjct: 146 ELSIIHYDLNTGNMLYDKE 164 >4OTP-A nrPDB Length = 352 Score = 38.0 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 30/167 (17%), Positives = 57/167 (34%), Gaps = 32/167 (19%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH--- 73 + + G V G A+KI + D + E + FRH Sbjct: 39 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 93 Query: 74 ----------------PHIIKLYQV---ISTP---TDFFMVMEYVSGGELFDYICKHGRV 111 ++I+L P +VM ++ ++ + K+ ++ Sbjct: 94 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 153 Query: 112 EEMEARRLFQQILSAVDYCHR-HMVVHRDLKPENVLLDAHMNAKIAD 157 E +AR L+ Q++ + ++ +VH DL N+L I D Sbjct: 154 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID 199 >6G5I-z nrPDB Length = 568 Score = 37.6 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 30/167 (17%), Positives = 57/167 (34%), Gaps = 32/167 (19%) Query: 17 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH--- 73 + + G V G A+KI + D + E + FRH Sbjct: 181 EINGCISTGKEANVYHA-STANGESRAIKIYKTSILVFKDRDKYVSGEFR----FRHGYC 235 Query: 74 ----------------PHIIKLYQV---ISTP---TDFFMVMEYVSGGELFDYICKHGRV 111 ++I+L P +VM ++ ++ + K+ ++ Sbjct: 236 KGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQL 295 Query: 112 EEMEARRLFQQILSAVDYCHR-HMVVHRDLKPENVLLDAHMNAKIAD 157 E +AR L+ Q++ + ++ +VH DL N+L I D Sbjct: 296 SESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-HGGGVYIID 341 >6FAI-l nrPDB Length = 425 Score = 34.2 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 29/183 (15%), Positives = 61/183 (33%), Gaps = 37/183 (20%) Query: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKI--LNRQKIRSLDVVGKIKR---------- 63 Y +G+T+GVG + + +V +KI L R S+ + Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 64 --------EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME 115 E Q + + K+ + +VME + G + + KH + Sbjct: 154 LSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMR-RLRKHKNIP--- 207 Query: 116 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA------HMNAKIADF--GLSNMMSDG 167 +L+ ++ + ++H D N+++ + DF +S D Sbjct: 208 --KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDA 265 Query: 168 EFL 170 ++ Sbjct: 266 DYY 268 >4ESA-B nrPDB Length = 146 Score = 33.4 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 27/49 (55%), Gaps = 5/49 (10%) Query: 25 GTFGKVKIGEHQLTGHKVA---VKILN--RQKIRSLDVVGKIKREIQNL 68 G+FG + E + KVA +K+L+ + ++++D + +I E+ L Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSIL 91 >6G18-v nrPDB Length = 552 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 28/74 (37%), Gaps = 6/74 (8%) Query: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 +VME ++G + H + +++ + H ++H D N Sbjct: 180 DYNRHAVVMELING---YPLCQIHHVEDPASVYDEAMELIVKLA---NHGLIHGDFNEFN 233 Query: 145 VLLDAHMNAKIADF 158 ++LD + + DF Sbjct: 234 LILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 33.0 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 28/74 (37%), Gaps = 6/74 (8%) Query: 85 TPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPEN 144 +VME ++G + H + +++ + H ++H D N Sbjct: 180 DYNRHAVVMELING---YPLCQIHHVEDPASVYDEAMELIVKLA---NHGLIHGDFNEFN 233 Query: 145 VLLDAHMNAKIADF 158 ++LD + + DF Sbjct: 234 LILDESDHITMIDF 247 >4GYG-A nrPDB Length = 397 Score = 32.6 bits (73), Expect = 0.49, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 29/78 (37%), Gaps = 16/78 (20%) Query: 91 MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH 150 +VM L D + + L+ +++ + +H ++H D N+L+ Sbjct: 188 IVM------SLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREE 241 Query: 151 MNAK----------IADF 158 +A+ I DF Sbjct: 242 KDAEDPSSITLTPIIIDF 259 >2WNF-A nrPDB Length = 298 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 46/115 (40%), Gaps = 14/115 (12%) Query: 379 KARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKP---YDIMAEVYRAM-KQLD--FEWKV 432 + + L T K L KW L ++ + +P D + E+++ + +D E ++ Sbjct: 35 RFNRSMQPLLTAKNAHLEEDTYKWWLRLQREKQPNNLNDTIRELFQVVPGNVDPLLEKRL 94 Query: 433 VNAYHLRVRRKNPVTGNYVKMSLQLY--LVDNRSYLLDFKSIDDEVVEQRSGSST 485 V+ R+ V GN + Y +D+ ++L E E GS T Sbjct: 95 VSC------RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKT 143 >6EF6-A nrPDB Length = 354 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 20/50 (40%), Gaps = 14/50 (28%) Query: 123 ILSAVDYCHRH-----------MVVHRDLKPENVLLDA---HMNAKIADF 158 + A D HR ++H DL+ N+L+D+ + DF Sbjct: 204 LTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANLLVDSSTPQRTITVIDF 253 >2X8T-A nrPDB Length = 471 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 13/28 (46%) Query: 72 RHPHIIKLYQVISTPTDFFMVMEYVSGG 99 +HP+++ + +MV SGG Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG 192 >4H05-A nrPDB Length = 273 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 10/14 (71%), Positives = 11/14 (78%) Query: 135 VVHRDLKPENVLLD 148 V H DL P+NVLLD Sbjct: 186 VCHGDLCPDNVLLD 199 >4A0G-A nrPDB Length = 831 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 26/70 (37%), Gaps = 5/70 (7%) Query: 18 LGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHII 77 L D +G G +V ++ T ++A+K+ R+ + + E + +I Sbjct: 433 LLDGVGKGWASRVYFSDNGSTAIEIALKMAFRKFCVDHNFCEATEEEKHIVVK-----VI 487 Query: 78 KLYQVISTPT 87 L T Sbjct: 488 ALRGSYHGDT 497 >5LXH-A nrPDB Length = 123 Score = 28.8 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 1/55 (1%) Query: 363 LKPHPERMPPLIADSPKARCP-LDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIM 416 K +P+R+P ++ +PKAR P LD P L V + + + R +P D + Sbjct: 28 RKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDAL 82 >2R2Q-A nrPDB Length = 110 Score = 28.8 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 1/55 (1%) Query: 363 LKPHPERMPPLIADSPKARCP-LDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIM 416 K +P+R+P ++ +PKAR P LD P L V + + + R +P D + Sbjct: 21 RKKYPDRVPVIVEKAPKARVPDLDKRKYLVPSDLTVGQFYFLIRKRIHLRPEDAL 75 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.145 0.421 Lambda K H 0.267 0.0443 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,445,129 Number of Sequences: 36641 Number of extensions: 959672 Number of successful extensions: 6586 Number of sequences better than 10.0: 513 Number of HSP's better than 10.0 without gapping: 942 Number of HSP's successfully gapped in prelim test: 57 Number of HSP's that attempted gapping in prelim test: 2509 Number of HSP's gapped (non-prelim): 1145 length of query: 552 length of database: 10,336,785 effective HSP length: 102 effective length of query: 450 effective length of database: 6,599,403 effective search space: 2969731350 effective search space used: 2969731350 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.4 bits)