BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P53779 (464 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1JNK-A nrPDB 889 0.0 2XS0-A nrPDB 734 0.0 3FI2-A nrPDB 719 0.0 3E7O-A nrPDB 659 0.0 5AWM-A nrPDB 618 e-177 3GC9-A nrPDB 338 4e-93 4MYG-A nrPDB 330 7e-91 4EWQ-A nrPDB 329 2e-90 1CM8-A nrPDB 324 4e-89 3OHT-A nrPDB 321 5e-88 4QTB-A nrPDB 266 1e-71 5NGU-A nrPDB 266 1e-71 6DTL-A nrPDB 258 3e-69 5Z33-A nrPDB 254 4e-68 4IC8-A nrPDB 253 1e-67 4ZSG-A nrPDB 250 1e-66 2F9G-A nrPDB 230 1e-60 4O2Z-A nrPDB 219 2e-57 3OZ6-A nrPDB 214 9e-56 4QNY-A nrPDB 201 8e-52 3RP9-A nrPDB 199 2e-51 3NIZ-A nrPDB 181 4e-46 2BPM-A nrPDB 176 2e-44 2I6L-A nrPDB 175 3e-44 3PG1-A nrPDB 174 6e-44 6GU6-A nrPDB 174 9e-44 3N9X-A nrPDB 174 1e-43 3NIE-A nrPDB 169 2e-42 2W96-B nrPDB 161 5e-40 4AU8-A nrPDB 159 3e-39 4BBM-A nrPDB 156 1e-38 4BGQ-A nrPDB 156 2e-38 1G3N-A nrPDB 156 2e-38 4E7W-A nrPDB 154 6e-38 1V0B-A nrPDB 154 7e-38 3GC0-A nrPDB 152 3e-37 3EB0-A nrPDB 151 7e-37 3ZDU-A nrPDB 149 2e-36 1UA2-A nrPDB 142 3e-34 5G6V-A nrPDB 139 3e-33 4KRC-A nrPDB 138 4e-33 3E3P-A nrPDB 137 8e-33 5AIR-A nrPDB 132 3e-31 5EFQ-A nrPDB 131 6e-31 4AGU-A nrPDB 130 9e-31 4NST-A nrPDB 129 2e-30 3MIA-A nrPDB 128 6e-30 5JN2-A nrPDB 125 6e-29 3MA6-A nrPDB 122 2e-28 4IAN-A nrPDB 122 3e-28 4RGJ-A nrPDB 122 3e-28 4CRL-A nrPDB 121 7e-28 5Y86-A nrPDB 120 8e-28 5ZTN-A nrPDB 120 1e-27 3LIJ-A nrPDB 120 2e-27 3NCG-A nrPDB 117 1e-26 2YCR-A nrPDB 116 2e-26 3I6U-A nrPDB 116 2e-26 3DFA-A nrPDB 116 3e-26 2WO6-A nrPDB 112 5e-25 3HZT-A nrPDB 111 8e-25 5X8I-B nrPDB 110 1e-24 4YZB-A nrPDB 110 1e-24 3DXN-A nrPDB 110 2e-24 5ES1-A nrPDB 108 3e-24 6FYV-A nrPDB 108 4e-24 2QNJ-A nrPDB 107 1e-23 4MVF-A nrPDB 107 2e-23 2F57-A nrPDB 106 2e-23 5XVU-A nrPDB 106 3e-23 4FIE-A nrPDB 105 4e-23 4XBR-A nrPDB 105 6e-23 5KZ7-A nrPDB 105 6e-23 2Q0N-A nrPDB 104 7e-23 4JDH-A nrPDB 104 7e-23 4EQM-A nrPDB 103 1e-22 6C9D-A nrPDB 102 4e-22 2PVN-A nrPDB 101 5e-22 3KN6-A nrPDB 101 5e-22 2JD5-A nrPDB 101 6e-22 4NIF-A nrPDB 101 7e-22 2HAK-A nrPDB 101 9e-22 4KS7-A nrPDB 99 3e-21 6HMD-A nrPDB 99 6e-21 6O6Q-A nrPDB 97 2e-20 3Q5I-A nrPDB 97 2e-20 5XZW-A nrPDB 96 4e-20 3H4J-B nrPDB 96 4e-20 6FD3-A nrPDB 95 5e-20 6EII-A nrPDB 95 6e-20 4JG6-A nrPDB 95 7e-20 4FG9-A nrPDB 94 9e-20 3Q53-A nrPDB 94 9e-20 4MD7-E nrPDB 94 1e-19 3BHH-A nrPDB 94 1e-19 2V7O-A nrPDB 94 2e-19 2VZ6-A nrPDB 94 2e-19 3DLS-A nrPDB 93 3e-19 5U6Y-A nrPDB 92 3e-19 4PDS-A nrPDB 92 4e-19 4I6B-A nrPDB 92 4e-19 6E2O-A nrPDB 92 6e-19 2WQN-A nrPDB 91 9e-19 5IG1-A nrPDB 90 2e-18 2VN9-A nrPDB 90 2e-18 5UNP-A nrPDB 89 3e-18 2W4O-A nrPDB 89 3e-18 3RAW-A nrPDB 89 3e-18 6QAU-A nrPDB 89 5e-18 2Z7Q-A nrPDB 89 5e-18 1ZXE-A nrPDB 89 6e-18 6CCF-A nrPDB 89 6e-18 2JC6-A nrPDB 88 6e-18 4B6L-A nrPDB 88 7e-18 4APC-A nrPDB 88 9e-18 2HW6-A nrPDB 87 1e-17 4M7I-A nrPDB 87 1e-17 3SOA-A nrPDB 87 1e-17 5JZN-A nrPDB 87 2e-17 3MN3-A nrPDB 87 2e-17 5FG8-A nrPDB 87 2e-17 3IS5-A nrPDB 86 2e-17 4LFI-A nrPDB 86 3e-17 2JAM-A nrPDB 86 3e-17 4UZD-A nrPDB 86 3e-17 3D2K-A nrPDB 86 4e-17 3DAK-A nrPDB 86 4e-17 4D28-A nrPDB 86 5e-17 4WNO-A nrPDB 85 6e-17 4X3F-A nrPDB 85 7e-17 3F3Z-A nrPDB 85 7e-17 5D9K-A nrPDB 85 8e-17 4OW8-A nrPDB 85 8e-17 1U5R-A nrPDB 85 9e-17 5F9E-A nrPDB 84 9e-17 2GCD-A nrPDB 84 9e-17 2X7G-A nrPDB 84 1e-16 4YNZ-A nrPDB 84 2e-16 2BDW-A nrPDB 84 2e-16 6B2Q-A nrPDB 84 2e-16 4CQG-A nrPDB 84 2e-16 6FDY-U nrPDB 83 2e-16 3GUB-A nrPDB 83 3e-16 6CMJ-A nrPDB 83 3e-16 3KK8-A nrPDB 83 3e-16 3UTO-A nrPDB 82 4e-16 1KOA-A nrPDB 82 4e-16 1KOB-A nrPDB 82 5e-16 3HKO-A nrPDB 81 8e-16 2WTK-C nrPDB 81 8e-16 6BDL-A nrPDB 81 8e-16 6CQF-A nrPDB 81 9e-16 4TNB-A nrPDB 81 9e-16 4REW-A nrPDB 81 1e-15 5WAX-A nrPDB 81 1e-15 5TQX-A nrPDB 80 1e-15 4CZT-A nrPDB 80 2e-15 2A27-A nrPDB 80 2e-15 4CFH-A nrPDB 80 2e-15 2XNP-A nrPDB 80 2e-15 1ZWS-A nrPDB 80 2e-15 3ORP-A nrPDB 80 2e-15 6CKI-A nrPDB 80 3e-15 2YAB-A nrPDB 80 3e-15 4C0T-A nrPDB 79 3e-15 3TAC-A nrPDB 79 4e-15 3ORZ-A nrPDB 79 4e-15 5YKS-A nrPDB 79 4e-15 4RED-A nrPDB 79 4e-15 3UDB-A nrPDB 79 5e-15 4WB7-A nrPDB 79 6e-15 3QD2-B nrPDB 78 6e-15 5LOH-A nrPDB 77 1e-14 5DYK-A nrPDB 77 1e-14 4CFF-A nrPDB 77 2e-14 5EZV-A nrPDB 77 2e-14 3ZUT-A nrPDB 77 2e-14 5YV8-A nrPDB 77 2e-14 5X3F-B nrPDB 77 2e-14 2X4F-A nrPDB 77 2e-14 1PHK-A nrPDB 77 2e-14 4B8L-A nrPDB 77 2e-14 4FR4-A nrPDB 76 3e-14 3NYO-A nrPDB 76 3e-14 3FXW-A nrPDB 76 3e-14 3VN9-A nrPDB 76 3e-14 5X5O-A nrPDB 76 3e-14 4D2V-A nrPDB 76 3e-14 5N23-A nrPDB 76 3e-14 4L42-A nrPDB 76 3e-14 2Y7J-A nrPDB 76 3e-14 2J90-A nrPDB 76 4e-14 3PPZ-A nrPDB 75 4e-14 2BRG-A nrPDB 75 5e-14 5DBX-A nrPDB 75 6e-14 5J5T-A nrPDB 75 7e-14 5FET-A nrPDB 75 7e-14 3COM-A nrPDB 75 8e-14 5H2U-A nrPDB 74 1e-13 4JXF-A nrPDB 74 1e-13 4RLP-A nrPDB 74 1e-13 6HV0-A nrPDB 74 2e-13 1FOT-A nrPDB 74 2e-13 3UC3-A nrPDB 73 2e-13 4QMW-A nrPDB 73 3e-13 4LG4-A nrPDB 73 3e-13 4AF3-A nrPDB 72 3e-13 2UV2-A nrPDB 72 4e-13 5D7A-A nrPDB 72 4e-13 6AO5-A nrPDB 72 4e-13 4YHJ-A nrPDB 72 6e-13 3UIU-A nrPDB 72 6e-13 3DB8-A nrPDB 72 6e-13 4GS6-A nrPDB 72 7e-13 2YZA-A nrPDB 72 7e-13 3C51-A nrPDB 72 7e-13 2A1A-B nrPDB 71 9e-13 4K33-A nrPDB 71 1e-12 3KA0-A nrPDB 71 1e-12 5EG3-A nrPDB 71 1e-12 1NY3-A nrPDB 70 2e-12 6ED6-A nrPDB 70 2e-12 2OZA-A nrPDB 70 2e-12 2OU7-A nrPDB 70 2e-12 6GVJ-A nrPDB 70 2e-12 3QA8-A nrPDB 70 3e-12 4PL5-B nrPDB 70 3e-12 2JDO-A nrPDB 70 3e-12 3ALO-A nrPDB 69 3e-12 4J52-A nrPDB 69 3e-12 3HDN-A nrPDB 69 4e-12 3KUL-B nrPDB 69 4e-12 3LM0-A nrPDB 69 4e-12 3HMP-A nrPDB 69 5e-12 6HXF-B nrPDB 69 5e-12 2PSQ-A nrPDB 69 5e-12 2R2P-A nrPDB 69 6e-12 1S9I-A nrPDB 69 6e-12 3TT0-A nrPDB 69 6e-12 3GQL-A nrPDB 69 6e-12 5HVK-A nrPDB 69 6e-12 5VD3-A nrPDB 69 6e-12 4U41-A nrPDB 68 6e-12 4KIK-B nrPDB 68 7e-12 4UY9-A nrPDB 68 8e-12 4XEY-B nrPDB 68 8e-12 6NPU-A nrPDB 68 9e-12 3DKO-A nrPDB 68 9e-12 5VO2-A nrPDB 68 9e-12 6E9W-A nrPDB 68 1e-11 5KKR-C nrPDB 68 1e-11 4WUA-A nrPDB 68 1e-11 3FME-A nrPDB 67 1e-11 2ZMD-A nrPDB 67 1e-11 5A46-A nrPDB 67 1e-11 4XCU-A nrPDB 67 1e-11 5AP3-A nrPDB 67 2e-11 3A8W-A nrPDB 67 2e-11 5HI2-A nrPDB 67 2e-11 4UYA-A nrPDB 67 2e-11 4AN9-A nrPDB 66 2e-11 2FO0-A nrPDB 66 3e-11 3EQC-A nrPDB 66 3e-11 4FZF-B nrPDB 66 3e-11 5HIE-A nrPDB 66 3e-11 2XIK-A nrPDB 66 3e-11 1JPA-A nrPDB 66 4e-11 3LLT-A nrPDB 65 6e-11 3DTC-A nrPDB 65 6e-11 2XYN-A nrPDB 65 7e-11 2PL0-A nrPDB 65 7e-11 3PFQ-A nrPDB 65 8e-11 5MJB-A nrPDB 65 8e-11 4HVI-A nrPDB 65 8e-11 4P5Q-A nrPDB 65 8e-11 2W1I-A nrPDB 65 8e-11 4RA4-A nrPDB 65 9e-11 4IDT-A nrPDB 65 9e-11 6BXI-A nrPDB 65 9e-11 5UIU-A nrPDB 64 1e-10 3A4O-X nrPDB 64 1e-10 1TKI-A nrPDB 64 1e-10 3IO7-A nrPDB 64 1e-10 3TXO-A nrPDB 64 1e-10 4EBW-A nrPDB 64 1e-10 2I0E-A nrPDB 64 1e-10 2H8H-A nrPDB 64 1e-10 5KCV-A nrPDB 64 2e-10 4AW2-A nrPDB 64 2e-10 4E93-A nrPDB 64 2e-10 3MV5-A nrPDB 64 2e-10 2Y6O-A nrPDB 63 2e-10 5L6P-A nrPDB 63 2e-10 4G3E-A nrPDB 63 3e-10 3OMV-A nrPDB 63 3e-10 5B2L-A nrPDB 62 4e-10 4CSV-A nrPDB 62 4e-10 6F3F-A nrPDB 62 4e-10 4TPT-A nrPDB 62 4e-10 4C59-A nrPDB 62 4e-10 2VWV-A nrPDB 62 4e-10 2J0K-A nrPDB 62 5e-10 2DQ7-X nrPDB 62 6e-10 1AD5-A nrPDB 62 6e-10 5SYS-A nrPDB 62 6e-10 5TUR-A nrPDB 62 6e-10 4RC3-A nrPDB 62 7e-10 2RIO-A nrPDB 62 8e-10 4PDO-A nrPDB 61 8e-10 3BGP-A nrPDB 61 8e-10 3TKU-A nrPDB 61 1e-09 3CJF-A nrPDB 61 1e-09 1VZO-A nrPDB 61 1e-09 6GQK-A nrPDB 60 2e-09 3PLS-A nrPDB 60 2e-09 4XI2-A nrPDB 60 3e-09 3PVW-A nrPDB 59 3e-09 5UUU-A nrPDB 59 4e-09 3G2F-A nrPDB 59 4e-09 4NEU-A nrPDB 59 4e-09 4Y93-A nrPDB 59 5e-09 1FVR-A nrPDB 59 6e-09 6E4F-A nrPDB 58 7e-09 5GNK-A nrPDB 58 8e-09 2HK5-A nrPDB 58 9e-09 5O2C-A nrPDB 58 1e-08 3G0E-A nrPDB 58 1e-08 4PWN-A nrPDB 57 1e-08 6CTH-A nrPDB 57 1e-08 3MY0-A nrPDB 57 1e-08 6DBN-A nrPDB 57 2e-08 4HZS-A nrPDB 57 2e-08 3SOC-A nrPDB 57 2e-08 1K9A-A nrPDB 57 2e-08 5GRN-A nrPDB 57 2e-08 1BYG-A nrPDB 56 3e-08 1U54-B nrPDB 56 3e-08 3LZB-A nrPDB 56 3e-08 5O2B-A nrPDB 56 3e-08 3SXS-A nrPDB 56 4e-08 3ZZW-A nrPDB 55 4e-08 4Y83-A nrPDB 55 5e-08 4X7Q-B nrPDB 55 5e-08 4JLC-A nrPDB 55 5e-08 4NFN-A nrPDB 55 6e-08 3QGY-A nrPDB 55 6e-08 4BTK-A nrPDB 55 6e-08 5U6B-A nrPDB 55 7e-08 6J5U-C nrPDB 55 9e-08 4AT3-A nrPDB 55 9e-08 2OGV-A nrPDB 55 1e-07 5WNO-A nrPDB 54 1e-07 5E8V-A nrPDB 54 1e-07 2QLU-A nrPDB 54 1e-07 5C26-A nrPDB 54 1e-07 4EUU-A nrPDB 54 1e-07 6DBM-A nrPDB 54 1e-07 4CRS-A nrPDB 54 2e-07 4M66-A nrPDB 54 2e-07 4FL3-A nrPDB 54 2e-07 4EUT-A nrPDB 54 2e-07 4OTD-A nrPDB 54 2e-07 2BUJ-A nrPDB 53 2e-07 6NT9-A nrPDB 53 2e-07 1U59-A nrPDB 53 2e-07 6FER-A nrPDB 53 2e-07 6O8B-A nrPDB 53 2e-07 4OLI-A nrPDB 53 3e-07 3Q4U-A nrPDB 53 3e-07 3MDY-A nrPDB 53 3e-07 5X02-A nrPDB 53 3e-07 5X1R-A nrPDB 52 5e-07 2OZO-A nrPDB 52 5e-07 5HLW-A nrPDB 52 5e-07 4LRM-A nrPDB 52 5e-07 3BBT-B nrPDB 52 5e-07 6FEX-A nrPDB 52 5e-07 3V5Q-A nrPDB 52 6e-07 3HNG-A nrPDB 51 8e-07 3C1X-A nrPDB 51 9e-07 3KRL-A nrPDB 51 9e-07 3M42-A nrPDB 51 1e-06 5TOS-A nrPDB 51 1e-06 4XLV-A nrPDB 50 1e-06 3BEA-A nrPDB 50 1e-06 3PP0-A nrPDB 50 2e-06 6BSD-A nrPDB 50 2e-06 4E20-A nrPDB 50 2e-06 4XUF-A nrPDB 50 2e-06 2H34-A nrPDB 50 2e-06 4RT7-A nrPDB 50 2e-06 3QUP-A nrPDB 50 3e-06 4LQP-A nrPDB 49 4e-06 5O0Y-A nrPDB 49 4e-06 3VHK-A nrPDB 49 4e-06 4R7H-A nrPDB 49 4e-06 5IKW-A nrPDB 49 5e-06 2PMN-X nrPDB 49 6e-06 5OAT-A nrPDB 49 6e-06 5FM2-A nrPDB 48 9e-06 3I81-A nrPDB 48 9e-06 2QKW-B nrPDB 48 9e-06 5TE0-A nrPDB 47 1e-05 5AMN-A nrPDB 47 1e-05 5FQD-C nrPDB 47 1e-05 4CI6-B nrPDB 47 1e-05 5LPZ-A nrPDB 47 1e-05 5LPV-A nrPDB 47 2e-05 1PY5-A nrPDB 47 2e-05 4XHL-A nrPDB 46 3e-05 4Y12-A nrPDB 46 4e-05 2PZI-A nrPDB 46 4e-05 1LUF-A nrPDB 46 4e-05 4H1J-A nrPDB 45 5e-05 2VD5-A nrPDB 45 6e-05 5AR8-A nrPDB 45 6e-05 5KMM-A nrPDB 45 7e-05 5XD6-A nrPDB 45 8e-05 4XHH-A nrPDB 44 1e-04 4M69-B nrPDB 44 2e-04 4TN6-A nrPDB 44 2e-04 4BTF-A nrPDB 44 2e-04 2Y4I-B nrPDB 43 2e-04 5CLR-A nrPDB 43 3e-04 4JRN-A nrPDB 43 3e-04 4F0G-A nrPDB 42 5e-04 3SV0-A nrPDB 42 5e-04 5U6C-A nrPDB 42 8e-04 3ZBF-A nrPDB 41 0.001 5J0A-A nrPDB 41 0.001 5WNL-A nrPDB 41 0.001 4IX6-A nrPDB 41 0.001 5L2Q-C nrPDB 40 0.001 3LMG-A nrPDB 40 0.002 5VC6-A nrPDB 40 0.002 4F9B-A nrPDB 40 0.002 3UIM-A nrPDB 40 0.003 2CMW-A nrPDB 40 0.003 2WTK-B nrPDB 39 0.005 3AOX-A nrPDB 39 0.005 1CSN-A nrPDB 39 0.005 4NT4-A nrPDB 39 0.007 6EQI-C nrPDB 38 0.009 5VE6-A nrPDB 38 0.012 2C47-A nrPDB 38 0.012 5X18-A nrPDB 37 0.015 6EWX-A nrPDB 37 0.022 2CHL-A nrPDB 36 0.029 4AZV-A nrPDB 36 0.040 4AZW-A nrPDB 36 0.045 3ENH-A nrPDB 36 0.046 4L68-A nrPDB 35 0.071 6BFN-A nrPDB 35 0.072 6G4J-A nrPDB 35 0.096 4YFF-A nrPDB 34 0.12 5M07-A nrPDB 34 0.13 6FAI-l nrPDB 34 0.15 5VDK-A nrPDB 33 0.22 6J6I-B nrPDB 33 0.30 4O1O-A nrPDB 33 0.36 5TGT-A nrPDB 31 0.95 6M7Z-A nrPDB 31 1.2 6DC0-A nrPDB 30 1.9 4OAU-C nrPDB 30 2.5 5CEK-A nrPDB 30 2.9 5UU1-A nrPDB 29 3.8 1TQM-A nrPDB 29 3.8 5ENY-A nrPDB 28 7.5 4Q25-A nrPDB 28 8.1 5DMZ-A nrPDB 28 9.6 >1JNK-A nrPDB Length = 423 Score = 889 bits (2298), Expect = 0.0, Method: Compositional matrix adjust. Identities = 423/423 (100%), Positives = 423/423 (100%) Query: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV Sbjct: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA 420 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA 420 Query: 421 VNS 423 VNS Sbjct: 421 VNS 423 >2XS0-A nrPDB Length = 386 Score = 734 bits (1896), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/379 (90%), Positives = 364/379 (96%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 +MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSR Sbjct: 2 SMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR 61 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 157 PFQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 62 PFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI 121 Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS 217 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS Sbjct: 122 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS 181 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 FMM P+VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIE Sbjct: 182 FMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIE 241 Query: 278 QLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 QLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLS Sbjct: 242 QLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 301 Query: 338 KMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 KMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKE Sbjct: 302 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 361 Query: 398 VMNSEEKTKNGVVKGQPSP 416 VM+ EE+TKNGV++GQPSP Sbjct: 362 VMDLEERTKNGVIRGQPSP 380 >3FI2-A nrPDB Length = 353 Score = 719 bits (1856), Expect = 0.0, Method: Compositional matrix adjust. Identities = 347/364 (95%), Positives = 347/364 (95%), Gaps = 11/364 (3%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDPAKRISVDDALQHPYINVWY DEREHTIEEWKELIYKEV Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWYXXX-----------XXXDEREHTIEEWKELIYKEV 349 Query: 399 MNSE 402 MNSE Sbjct: 350 MNSE 353 >3E7O-A nrPDB Length = 360 Score = 659 bits (1699), Expect = 0.0, Method: Compositional matrix adjust. Identities = 308/359 (85%), Positives = 331/359 (92%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 S +D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRPFQN Sbjct: 2 SHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQN 61 Query: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL 161 QTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI MEL Sbjct: 62 QTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMEL 121 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+FMMT Sbjct: 122 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMT 181 Query: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQLGT Sbjct: 182 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGT 241 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 P EFM LQPTVRNYVENRP Y G+ F +LFPD +FP++SE +K+K SQARDLLSKMLV Sbjct: 242 PSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLV 301 Query: 342 IDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 IDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEVM+ Sbjct: 302 IDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >5AWM-A nrPDB Length = 394 Score = 618 bits (1594), Expect = e-177, Method: Compositional matrix adjust. Identities = 287/379 (75%), Positives = 325/379 (85%), Gaps = 3/379 (0%) Query: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 H M+ ++ +Q Y+VEVGD+ FT+ RY NL+PIGSGAQGIVCAAYD + +NVAIK Sbjct: 18 GSHRTMTTAQ--HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK 75 Query: 94 KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANL 153 KLSRPFQN THAKRAYRE LMK VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANL Sbjct: 76 KLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANL 135 Query: 154 CQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART 213 CQVIQM+LDH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLART Sbjct: 136 CQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART 195 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 AGT+FMMTPYVVTRYYRAPEVILGMGY ENVDIWSVGCIMGEM+R +LFPG D+IDQWN Sbjct: 196 AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWN 255 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN-KLKASQA 332 K+IEQLGTP P FM++LQPTVRNYVENRP+Y G +F +LFPD LFP D+ N + KAS A Sbjct: 256 KIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDA 315 Query: 333 RDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 R+LLSKMLVIDP +RISVD+AL+H YINVWYD EV+AP P+ YD +DEREHT+E+WKE Sbjct: 316 RNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKE 375 Query: 393 LIYKEVMNSEEKTKNGVVK 411 LIY+EVM+ E N + Sbjct: 376 LIYEEVMDYEAHNTNNRTR 394 >3GC9-A nrPDB Length = 370 Score = 338 bits (866), Expect = 4e-93, Method: Compositional matrix adjust. Identities = 173/357 (48%), Positives = 241/357 (67%), Gaps = 21/357 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R Sbjct: 14 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 73 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E + Sbjct: 74 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHV 133 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V D L+ILDFGLAR A MT YV T Sbjct: 134 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE--MTGYVAT 191 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE Sbjct: 192 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 251 Query: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + K+ R Y+++ P +F + N L A DLL +MLV+D Sbjct: 252 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA--------NPL----AIDLLGRMLVLDS 299 Query: 345 AKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 +R+S +AL H Y + ++DP E EA P YD+ ++ +E T+EEWKEL Y+EV++ Sbjct: 300 DQRVSAAEALAHAYFSQYHDPEDEPEAEP---YDESVEAKERTLEEWKELTYQEVLS 353 >4MYG-A nrPDB Length = 372 Score = 330 bits (846), Expect = 7e-91, Method: Compositional matrix adjust. Identities = 169/355 (47%), Positives = 231/355 (65%), Gaps = 17/355 (4%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR Sbjct: 29 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 88 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167 AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 89 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 148 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR Sbjct: 149 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE--MTGYVVTR 206 Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF Sbjct: 207 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 266 Query: 287 MKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++KL ++Y+++ P+ F +LFP + + QA DLL KML +D Sbjct: 267 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 314 Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N Sbjct: 315 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVN 368 >4EWQ-A nrPDB Length = 383 Score = 329 bits (843), Expect = 2e-90, Method: Compositional matrix adjust. Identities = 175/376 (46%), Positives = 241/376 (64%), Gaps = 19/376 (5%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87 VD+ ++ + S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D Sbjct: 11 VDLGTENLYFQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTG 70 Query: 88 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 147 VA+KKLSRPFQ+ HAKR YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV Sbjct: 71 LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH 130 Query: 148 LMDANLCQVIQ-MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 LM A+L +++ +L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKIL Sbjct: 131 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 190 Query: 207 DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 265 DFGLAR T MT YV TR+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG Sbjct: 191 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 248 Query: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 D+IDQ ++ +GTP E +KK+ + RNY+++ + + F +F + Sbjct: 249 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA-------- 300 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 N L A DLL KMLV+D KRI+ AL H Y ++DP + P YD+ + R+ Sbjct: 301 NPL----AVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRD 354 Query: 385 HTIEEWKELIYKEVMN 400 I+EWK L Y EV++ Sbjct: 355 LLIDEWKSLTYDEVIS 370 >1CM8-A nrPDB Length = 367 Score = 324 bits (831), Expect = 4e-89, Method: Compositional matrix adjust. Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR Sbjct: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+ Sbjct: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT Sbjct: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E Sbjct: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 Query: 286 FMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D Sbjct: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 +R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ + Sbjct: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 Query: 405 TKNGVVKGQPSP 416 + G + +P Sbjct: 355 RQLGARVSKETP 366 >3OHT-A nrPDB Length = 389 Score = 321 bits (822), Expect = 5e-88, Method: Compositional matrix adjust. Identities = 170/364 (46%), Positives = 233/364 (64%), Gaps = 19/364 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +RYQ L P+GSGA G VC++YD +A+KKLSRPFQ+ HAKR Sbjct: 37 FYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKR 96 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 YREL L+K + H+N+I LL+VFTP +LEEF DVYLV LM A+L +++ +L + + Sbjct: 97 TYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 156 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 157 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 214 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y VDIWSVGCIM E++ + LFPG D+I+Q +++ GTP Sbjct: 215 RWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAS 274 Query: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + ++ RNY+ + P+ F +F + N L A DLL KMLV+D Sbjct: 275 VISRMPSHEARNYINSLPQMPKRNFADVFIGA--------NPL----AVDLLEKMLVLDT 322 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 KRI+ +AL HPY + ++DP + P + YD+ + R+ IEEWK L Y+EV + E Sbjct: 323 DKRITASEALAHPYFSQYHDPD--DEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETP 380 Query: 405 TKNG 408 +G Sbjct: 381 PFDG 384 >4QTB-A nrPDB Length = 380 Score = 266 bits (681), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 148/355 (41%), Positives = 224/355 (63%), Gaps = 26/355 (7%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 V F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 32 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 90 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLY 171 ++ H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LY Sbjct: 91 QILLRFRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 149 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPYVVT 226 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A T F +T YV T Sbjct: 150 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGF-LTEYVAT 208 Query: 227 RYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 209 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 268 Query: 286 FMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + + RNY+++ P + + KLFP S S+A DLL +ML +P Sbjct: 269 DLNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNP 316 Query: 345 AKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 KRI+V++AL HPY+ +YDP E A P + +LD+ E KELI++E Sbjct: 317 NKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQET 369 >5NGU-A nrPDB Length = 381 Score = 266 bits (680), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 150/355 (42%), Positives = 226/355 (63%), Gaps = 26/355 (7%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 V F V RY NL IG GA G+VC+AYD + VAIKK+S PF++QT+ +R RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREI 91 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171 ++ H+NII + N T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY Sbjct: 92 KILLRFRHENIIGI-NDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPYVVT 226 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A T F +T YV T Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGF-LTEYVAT 209 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 210 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 269 Query: 286 FMK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + + RNY+ + P + + +LFP++ S+A DLL KML +P Sbjct: 270 DLNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNP 317 Query: 345 AKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E Sbjct: 318 HKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEET 370 >6DTL-A nrPDB Length = 364 Score = 258 bits (660), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 145/358 (40%), Positives = 216/358 (60%), Gaps = 20/358 (5%) Query: 47 QFYSVEVGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 +F + + F V +Y+ + PIG GA GIVC+A ++ + +VAIKK++ F N+ A Sbjct: 14 RFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA 73 Query: 106 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDH 163 KR RE+ L++ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I+ L Sbjct: 74 KRTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSE 132 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 223 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S MT Y Sbjct: 133 EHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEY 192 Query: 224 VVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 VVTR+YRAPE++L Y +D+WSVGCI E++ K LFPGRD++ Q ++E +GTP Sbjct: 193 VVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTP 252 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 E ++ L + Y+ P Y + FP ++ P A DL+ KML Sbjct: 253 SEEELEFLNENAKRYIRQLPPYPRQSITDKFP-TVHPL-----------AIDLIEKMLTF 300 Query: 343 DPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM 399 DP +RI+V DAL HPY+N +D + E E P +D + + E+ KELIY+E + Sbjct: 301 DPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFD--FENHALSEEQMKELIYREAL 356 >5Z33-A nrPDB Length = 425 Score = 254 bits (650), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 146/388 (37%), Positives = 220/388 (56%), Gaps = 33/388 (8%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 +V + F V +RY K +G GA GIVCAA + VAIKK++ F + AKRA RE Sbjct: 21 KVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALRE 80 Query: 112 LVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSY 168 + L++ H+NI L ++ P+ + F + YL ELM+ +L +I+ L Sbjct: 81 IKLLQHFRGHRNITCLYDMDIPRP--DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQS 138 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPY 223 +YQ+LCG+K++HSA ++HRDLKP N++V +DC LKI DFGLAR + MT Y Sbjct: 139 FIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEY 198 Query: 224 VVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 V TR+YRAPE++L Y + +D+WSVGCI+ E++ + F GRDY+DQ N+++ LGTP Sbjct: 199 VATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTP 258 Query: 283 CPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 E + ++ P + YV N P A FP LFP++ A DLL +ML Sbjct: 259 NEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNA------------NPDALDLLDRMLA 306 Query: 342 IDPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 DP+ RISV+ AL+HPY+++W+D + E + P +D ++ E + E +++I EV Sbjct: 307 FDPSSRISVEQALEHPYLHIWHDASDEPDCPTTFNFDFEVVE---DVGEMRKMILDEVYR 363 Query: 401 SEEKTKNGVVKGQPSPSGAAVNSSESLP 428 + +V+ P G + +P Sbjct: 364 FRQ-----LVRTAPGAGGHGAPHAPQVP 386 >4IC8-A nrPDB Length = 442 Score = 253 bits (645), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 146/374 (39%), Positives = 222/374 (59%), Gaps = 28/374 (7%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQ 172 +K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 167 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 228 YYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++ + VR Y+++ P + + ++P AD QA LL +ML +P+ Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 335 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 RIS AL+HP++ ++DP E + PP +D D T E KE I E+ + + Sbjct: 336 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEIEDFHAR 393 Query: 405 TKNGV---VKGQPS 415 + G+ ++ QPS Sbjct: 394 -REGIRQQIRFQPS 406 >4ZSG-A nrPDB Length = 347 Score = 250 bits (638), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 142/354 (40%), Positives = 213/354 (60%), Gaps = 28/354 (7%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL ++K Sbjct: 2 TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 61 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ----MELDHERMSYLLYQ 172 H NII++ ++ P EF+ VY+V++LM+++L Q+I + L+H R Y LYQ Sbjct: 62 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVR--YFLYQ 119 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 120 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 179 Query: 228 YYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P Sbjct: 180 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 239 Query: 287 MKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++ + VR Y+++ P + + ++P AD QA LL +ML +P+ Sbjct: 240 IQAVGAERVRAYIQSLPPRQPVPWETVYPG----AD--------RQALSLLGRMLRFEPS 287 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 RIS AL+HP++ ++DP E + PP +D D T E KE I E+ Sbjct: 288 ARISAAAALRHPFLAKYHDPDDEPDCAPP--FDFAFDREALTRERIKEAIVAEI 339 >2F9G-A nrPDB Length = 353 Score = 230 bits (586), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 132/354 (37%), Positives = 192/354 (54%), Gaps = 42/354 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA G+VC+A VAIKK+ PF A R RE+ ++K H+NII++ N+ Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHR 188 P + E F +VY++ ELM +L +VI + L + + Y +YQ L +K LH + +IHR Sbjct: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 Query: 189 DLKPSNIVVKSDCTLKILDFGLART-----------AGTSFMMTPYVVTRYYRAPEVILG 237 DLKPSN+++ S+C LK+ DFGLAR G MT YV TR+YRAPEV+L Sbjct: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 Query: 238 MG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP-------CPEFMKK 289 Y +D+WS GCI+ E+ + +FPGRDY Q + +GTP C E Sbjct: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE---- 252 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 P R Y+++ P Y K+FP + DLL +MLV DPAKRI+ Sbjct: 253 -SPRAREYIKSLPMYPAAPLEKMFPRV------------NPKGIDLLQRMLVFDPAKRIT 299 Query: 350 VDDALQHPYINVWYDP---AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 +AL+HPY+ ++DP E E PP ++ + T ++ K+LI+ E+ + Sbjct: 300 AKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >4O2Z-A nrPDB Length = 377 Score = 219 bits (557), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 124/340 (36%), Positives = 185/340 (54%), Gaps = 22/340 (6%) Query: 32 YIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVA 91 Y + +S K+ F V S F V +Y LK +G GA GI C+ D V+ Sbjct: 15 YFQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVS 74 Query: 92 IKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTP-QKTLEEFQDVYLVMELMD 150 IKK F++ KR RE+ +M+ +H+N+++++N+ P ++ F+DVY+V LMD Sbjct: 75 IKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD 134 Query: 151 ANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 ++ V++ L+ M Y +YQ+L G+K+LHSA + HRDLKP+N+V C LKI+DF Sbjct: 135 VDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDF 194 Query: 209 GLARTAGTSFM-MTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGR 266 GL+R+ + +T YV+TR+YR PE++L Y VDIWSVGCI EM K +FPGR Sbjct: 195 GLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGR 254 Query: 267 DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE--NRPKYAGLTFPKLFPDSLFPADSEH 324 + +DQ + + +G P ++ R +E N L PKL P Sbjct: 255 NTMDQLRMIAQHIGKPPASIVEH-----REALEKLNELPDGSLNIPKLVP---------- 299 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYD 364 ++ D LSKM +DP+KR + D L HPY+ +D Sbjct: 300 GLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 >3OZ6-A nrPDB Length = 388 Score = 214 bits (544), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 128/372 (34%), Positives = 214/372 (57%), Gaps = 40/372 (10%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE-LVLMKCV 118 VL++Y+ +K +G GA GIV + D VA+KK+ FQN T A+R +RE ++L + Sbjct: 7 VLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELS 66 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGI 177 H+NI++LLNV +DVYLV + M+ +L VI+ L+ Y++YQ++ I Sbjct: 67 GHENIVNLLNVLRADND----RDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVI 122 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----------------AGTSF-- 218 K+LHS G++HRD+KPSNI++ ++C +K+ DFGL+R+ +F Sbjct: 123 KYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 219 ---MMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK 274 ++T YV TR+YRAPE++LG Y + +D+WS+GCI+GE++ K +FPG ++Q + Sbjct: 183 DQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLER 242 Query: 275 VIEQLGTPCPE--------FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNK 326 +I + P E F K + +++ VE R F K + + L + + + Sbjct: 243 IIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTK-WKNLLLKINPKAD- 300 Query: 327 LKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHT 386 +A DLL K+L +P KRIS +DAL+HP+++++++P E I D +H+ Sbjct: 301 -CNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHS 359 Query: 387 IEEWKELIYKEV 398 I++++ L+Y E+ Sbjct: 360 IDDYRNLVYSEI 371 >4QNY-A nrPDB Length = 354 Score = 201 bits (510), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 119/343 (34%), Positives = 196/343 (57%), Gaps = 24/343 (6%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLD-RNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNH 120 RY + IG+G+ G+V A D D R VA+K++++ F+ AKR RE+ L+ N Sbjct: 21 RYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFND 80 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIK 178 NII L N+ TP+ E F Y+VM++M+ +L QV++ EL + + +YQ L + Sbjct: 81 DNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALRALH 139 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVIL- 236 +HSAG+IHRD+ P+NI+V ++C LKI DFGLA+ MT YV R+YRAPE+++ Sbjct: 140 IIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVME 199 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT-VR 295 Y +D+W +GCI+GE++ + LF G+D ++Q +K+++ +GTP E + + + + Sbjct: 200 DKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQ 259 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 Y++ + + + +P + + +A DLL MLV +P +RI+V A++ Sbjct: 260 KYLKKKSHRPQADWRQRYPTA------------SPEALDLLRHMLVFNPKRRITVLQAMR 307 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREH-TIEEWKELIYKE 397 HP++ +D A+ + DE E TI + K IY+E Sbjct: 308 HPFLEQLHDDADDNLSYALF---RFDENEQKTIVDVKRAIYEE 347 >3RP9-A nrPDB Length = 458 Score = 199 bits (506), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 125/367 (34%), Positives = 194/367 (52%), Gaps = 76/367 (20%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 S + + RY+ IG+G+ G VC AYD + R VAIKK+ R F++ KR RE+ ++ Sbjct: 47 SDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAIL 106 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQM 173 +NH +++ +L++ P K +E+F ++Y+V+E+ D++ ++ + + L + LLY + Sbjct: 107 NRLNHDHVVKVLDIVIP-KDVEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNL 165 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-----GTSFM--------- 219 L G+K++HSAGI+HRDLKP+N +V DC++K+ DFGLART G S + Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 220 --------------MTPYVVTRYYRAPEVI-LGMGYKENVDIWSVGCIMGE---MVRHKI 261 +T +VVTR+YRAPE+I L Y E +D+WS+GCI E M++ + Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 262 --------LFPG--------------------RDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 LFPG R DQ N + LGTP E ++ L+ Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 294 -VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 + Y+ PK G + FP S AD+ H LL +MLV +P KRI++++ Sbjct: 346 DAKRYIRIFPKREGTDLAERFPAS--SADAIH----------LLKRMLVFNPNKRITINE 393 Query: 353 ALQHPYI 359 L HP+ Sbjct: 394 CLAHPFF 400 >3NIZ-A nrPDB Length = 311 Score = 181 bits (460), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 116/309 (37%), Positives = 170/309 (55%), Gaps = 32/309 (10%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++++YQ L+ +G G G+V A D+ R VA+K++ +++ A RE+ L+K ++ Sbjct: 19 LMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCG 176 H NI+SL++V ++ L LV E M+ +L +V+ + L ++ LYQ+L G Sbjct: 78 HPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRG 131 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM-MTPYVVTRYYRAPEVI 235 + H H I+HRDLKP N+++ SD LK+ DFGLAR G T VVT +YRAP+V+ Sbjct: 132 VAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVL 191 Query: 236 LG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 +G Y +VDIWS+GCI EM+ K LFPG DQ K+ LGTP P ++Q Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQ--- 248 Query: 295 RNYVENRPKYAGLTFPKLFP----DSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 P + TF ++F S+ P + + DLLS ML DP KRIS Sbjct: 249 -----ELPLWKQRTF-QVFEKKPWSSIIPGFCQ-------EGIDLLSNMLCFDPNKRISA 295 Query: 351 DDALQHPYI 359 DA+ HPY Sbjct: 296 RDAMNHPYF 304 >2BPM-A nrPDB Length = 309 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 114/310 (36%), Positives = 164/310 (52%), Gaps = 33/310 (10%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMEL--------MDANLCQVIQMELDHERMSYLLYQ 172 NI+ LL+V + L YLV E MDA+ I + L + L+Q Sbjct: 66 PNIVKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQ 115 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRA 231 +L G+ HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRA Sbjct: 116 LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 175 Query: 232 PEVILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PE++LG Y VDIWS+GCI EMV + LFPG IDQ ++ LGTP E + Sbjct: 176 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP-DEVVWPG 234 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 ++ +Y + PK+A F K+ P P D + R LLS+ML DP KRIS Sbjct: 235 VTSMPDYKPSFPKWARQDFSKVVP----PLDED--------GRSLLSQMLHYDPNKRISA 282 Query: 351 DDALQHPYIN 360 AL HP+ Sbjct: 283 KAALAHPFFQ 292 >2I6L-A nrPDB Length = 320 Score = 175 bits (444), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 104/325 (32%), Positives = 173/325 (53%), Gaps = 29/325 (8%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F + RY +LKP+G G G+V +A D D+ VAIKK+ + K A RE+ +++ Sbjct: 7 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRR 64 Query: 118 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVI-QMELDHERMSY 168 ++H NI+ + + P + L E VY+V E M+ +L V+ Q L E Sbjct: 65 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 124 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSF----MMTPY 223 +YQ+L G+K++HSA ++HRDLKP+N+ + + D LKI DFGLAR + ++ Sbjct: 125 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 +VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E + Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 244 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 E ++L + Y+ N +T P L P S +A D L ++L Sbjct: 245 HEEDRQELLSVIPVYIRN-----DMTEPHKPLTQLLPGISR-------EAVDFLEQILTF 292 Query: 343 DPAKRISVDDALQHPYINVWYDPAE 367 P R++ ++AL HPY++++ P + Sbjct: 293 SPMDRLTAEEALSHPYMSIYSFPMD 317 >3PG1-A nrPDB Length = 362 Score = 174 bits (442), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 110/321 (34%), Positives = 166/321 (51%), Gaps = 31/321 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP---------FQNQTHAKRAYRELVL 114 Y + I SG+ G VCA D+ VAIK++ + KR RE+ L Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 115 MKCVNHKNIISLLNVFTPQKTLEE--FQDVYLVMELMDANLCQVI---QMELDHERMSYL 169 + +H NI+ L ++F EE +YLV ELM +L QVI ++ + + + Y Sbjct: 83 LNHFHHPNILGLRDIFV---HFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYF 139 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 +Y +L G+ LH AG++HRDL P NI++ + + I DF LAR T YV R+Y Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWY 199 Query: 230 RAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 RAPE+++ G+ + VD+WS GC+M EM K LF G + +Q NK++E +GTP E + Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVV 259 Query: 289 KL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 P+ R+Y+ N P ++ P A DL++KML +P +R Sbjct: 260 MFSSPSARDYLRNSLS----NVPARAWTAVVPTAD-------PVALDLIAKMLEFNPQRR 308 Query: 348 ISVDDALQHPYINVWYDPAEV 368 IS + AL+HPY +DP ++ Sbjct: 309 ISTEQALRHPYFESLFDPLDL 329 >6GU6-A nrPDB Length = 302 Score = 174 bits (440), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 113/307 (36%), Positives = 161/307 (52%), Gaps = 26/307 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 175 NI+SL Q L + +YL+ E + +L + + +D + LYQ+L Sbjct: 66 PNIVSL------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEV 234 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 235 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 +LG Y VDIWS+G I E+ K LF G IDQ ++ LGTP E +++ + Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 238 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 +++Y TFPK P SL + H K DLLSKML+ DPAKRIS A Sbjct: 239 LQDYKN--------TFPKWKPGSL----ASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 286 Query: 354 LQHPYIN 360 L HPY N Sbjct: 287 LNHPYFN 293 >3N9X-A nrPDB Length = 432 Score = 174 bits (440), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 111/345 (32%), Positives = 175/345 (50%), Gaps = 68/345 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G+ G V AYD ++NVAIKK++R F++ KR RE+ ++ + II L ++ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIH 187 P L+ F ++Y+V+E+ D++L ++ + + L E + +LY +L G +H +GIIH Sbjct: 94 IIPDDLLK-FDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYNLLLGENFIHESGIIH 152 Query: 188 RDLKPSNIVVKSDCTLKILDFGLARTAGTS-----------------------FMMTPYV 224 RDLKP+N ++ DC++K+ DFGLART + +T +V Sbjct: 153 RDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSHV 212 Query: 225 VTRYYRAPEVI-LGMGYKENVDIWSVGCIMGE---MVRHKI--------LFPG------- 265 VTR+YRAPE+I L Y +++DIWS GCI E M++ I LFPG Sbjct: 213 VTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLS 272 Query: 266 ----------RDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFP 314 + DQ N + +GTP + +K + +P V Y++ P + + +P Sbjct: 273 PDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQKYP 332 Query: 315 DSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + +LL ML +P KRI++D AL HPY+ Sbjct: 333 SI------------SDDGINLLESMLKFNPNKRITIDQALDHPYL 365 >3NIE-A nrPDB Length = 429 Score = 169 bits (429), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 113/348 (32%), Positives = 175/348 (50%), Gaps = 71/348 (20%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G+ G V AYD ++NVAIKK++R F++ KR RE+ ++ + II L ++ Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIH 187 P+ L+ F ++Y+V+E+ D++L ++ + + L + + +LY +L G K +H +GIIH Sbjct: 96 IIPEDLLK-FDELYIVLEIADSDLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGIIH 154 Query: 188 RDLKPSNIVVKSDCTLKILDFGLARTAGT--------------------------SFMMT 221 RDLKP+N ++ DC++KI DFGLART + +T Sbjct: 155 RDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLT 214 Query: 222 PYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGE---MVRHKI--------LFPG---- 265 +VVTR+YRAPE+IL Y ++DIWS GCI E M++ I LFPG Sbjct: 215 SHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCF 274 Query: 266 -------------RDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPK 311 + DQ N + +GTP E +K + + V Y++ P G+ K Sbjct: 275 PLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFPTRDGIDLSK 334 Query: 312 LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + + + DLL ML + KRI++D AL HPY+ Sbjct: 335 KYSSI------------SKEGIDLLESMLRFNAQKRITIDKALSHPYL 370 >2W96-B nrPDB Length = 306 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 111/305 (36%), Positives = 154/305 (50%), Gaps = 23/305 (7%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK---CVN 119 RY+ + IG GA G V A D VA+K + P + RE+ L++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLC 175 H N++ L++V +T E + V LV E +D +L + L E + L+ Q L Sbjct: 65 HPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR + P VVT +YRAPEV+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVL 183 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 L Y VD+WSVGCI EM R K LF G DQ K+ + +G P PE Sbjct: 184 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP-PE---------- 232 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 ++ P+ L P P S +++ S A+ LL +ML +P KRIS ALQ Sbjct: 233 ---DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFRALQ 288 Query: 356 HPYIN 360 H Y++ Sbjct: 289 HSYLH 293 >4AU8-A nrPDB Length = 296 Score = 159 bits (402), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 106/315 (33%), Positives = 160/315 (50%), Gaps = 35/315 (11%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + HK Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIK 178 NI+ L +V K L LV E D +L + +LD E + L+Q+L G+ Sbjct: 66 NIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM-MTPYVVTRYYRAPEVILG 237 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ G Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 238 MG-YKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y ++D+WS GCI E+ + LFPG D DQ ++ LGTP E Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEE---------- 229 Query: 296 NYVENRPKYAGLT-FPKLFPDSLFPADSEH----NKLKASQARDLLSKMLVIDPAKRISV 350 ++ +T P P ++PA + KL A+ RDLL +L +P +RIS Sbjct: 230 -------QWPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT-GRDLLQNLLKCNPVQRISA 281 Query: 351 DDALQHPYINVWYDP 365 ++ALQHPY + + P Sbjct: 282 EEALQHPYFSDFCPP 296 >4BBM-A nrPDB Length = 331 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 103/309 (33%), Positives = 162/309 (52%), Gaps = 22/309 (7%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F +++Y+NL +G G+ G+V + R VAIKK ++ K A RE+ L+K Sbjct: 21 FQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQ 80 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQML 174 + H+N+++LL V +K YLV E +D + +++ LD++ + L+Q++ Sbjct: 81 LRHENLVNLLEVCKKKKRW------YLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQII 134 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPE 233 GI HS IIHRD+KP NI+V +K+ DFG ART A + V TR+YRAPE Sbjct: 135 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPE 194 Query: 234 VILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 +++G + Y + VD+W++GC++ EM + LFPG IDQ ++ LG L P Sbjct: 195 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN--------LIP 246 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 + P +AG+ P++ P + + KL + DL K L IDP KR + Sbjct: 247 RHQELFNKNPVFAGVRLPEIKERE--PLERRYPKL-SEVVIDLAKKCLHIDPDKRPFCAE 303 Query: 353 ALQHPYINV 361 L H + + Sbjct: 304 LLHHDFFQM 312 >4BGQ-A nrPDB Length = 304 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 99/306 (32%), Positives = 161/306 (52%), Gaps = 25/306 (8%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 V+ +++ L +G GA G+V VAIKK +N+ + REL +++ + Sbjct: 9 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 68 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH----ERMSYLLYQML 174 +NI+ L F + L YLV E ++ N+ ++++ E+ + E++ +YQ++ Sbjct: 69 KQENIVELKEAFRRRGKL------YLVFEYVEKNMLELLE-EMPNGVPPEKVKSYIYQLI 121 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAP 232 I H I+HRD+KP N+++ + LK+ DFG AR + G + V TR+YR+P Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSP 181 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 E++LG Y ++VD+WSVGCI+GE+ + LFPG IDQ + + LG P P KL Sbjct: 182 ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPSEQMKL-- 238 Query: 293 TVRNYVENRPKYAGLTFPKL-FPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 + P++ GL FP + P SL + + + S DL+ +L +DPA R + Sbjct: 239 -----FYSNPRFHGLRFPAVNHPQSL---ERRYLGILNSVLLDLMKNLLKLDPADRYLTE 290 Query: 352 DALQHP 357 L HP Sbjct: 291 QCLNHP 296 >1G3N-A nrPDB Length = 326 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 105/307 (34%), Positives = 154/307 (50%), Gaps = 24/307 (7%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAV-LDRNVAIKKLSRPFQNQTHAKRAYRELVLMK---C 117 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLC----QVIQMELDHERMSYLLYQM 173 H N++ L +V T +T E + + LV E +D +L +V + + E + +++Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETK-LTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR +T VVT +YRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+L Y VD+WSVGCI EM R K LF G +DQ K+++ +G P Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE--------- 240 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 E+ P+ L S P + + +DLL K L +PAKRIS A Sbjct: 241 -----EDWPRDVALPRQAFHSKSAQPIEKFVTDID-ELGKDLLLKCLTFNPAKRISAYSA 294 Query: 354 LQHPYIN 360 L HPY Sbjct: 295 LSHPYFQ 301 >4E7W-A nrPDB Length = 394 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 106/311 (34%), Positives = 163/311 (52%), Gaps = 40/311 (12%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL--SRPFQNQTHAKRAYRELVLMKCVNHK 121 Y N K IG+G+ G+V A V VAIKK+ + F+N REL +M+ V H Sbjct: 42 YTNCKVIGNGSFGVVFQA-KLVESDEVAIKKVLQDKRFKN--------RELQIMRIVKHP 92 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMD----------ANLCQVIQMELDHERMSYLLY 171 N++ L F ++ + LV+E + A L Q + M L + +Y Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLL----IKLYMY 148 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYR 230 Q+L + ++HS GI HRD+KP N+++ LK++DFG A+ Y+ +RYYR Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYR 208 Query: 231 APEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APE+I G Y N+DIWS GC+M E+++ + LFPG IDQ ++I+ LGTP E +K Sbjct: 209 APELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKT 268 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + P NY+E++ FP++ P P A DL+S++L P+ R++ Sbjct: 269 MNP---NYMEHK-------FPQIRPH---PFSKVFRPRTPPDAIDLISRLLEYTPSARLT 315 Query: 350 VDDALQHPYIN 360 +AL HP+ + Sbjct: 316 AIEALCHPFFD 326 >1V0B-A nrPDB Length = 288 Score = 154 bits (390), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 108/304 (35%), Positives = 153/304 (50%), Gaps = 25/304 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +++Y L+ IG G G+V A + A+KK+ +++ RE+ ++K + H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGI 177 NI+ L +V +K L LV E +D +L +++ + L+ L Q+L GI Sbjct: 60 SNIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGI 113 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM-MTPYVVTRYYRAPEVIL 236 + H ++HRDLKP N+++ + LKI DFGLAR G T VVT +YRAP+V++ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLM 173 Query: 237 G-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y +DIWSVGCI EMV LFPG DQ ++ LGTP K P V Sbjct: 174 GSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPN----SKNWPNVT 229 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 PKY P P +S L S DLLSKML +DP +RI+ AL+ Sbjct: 230 EL----PKYD----PNFTVYEPLPWESFLKGLDES-GIDLLSKMLKLDPNQRITAKQALE 280 Query: 356 HPYI 359 H Y Sbjct: 281 HAYF 284 >3GC0-A nrPDB Length = 329 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 105/311 (33%), Positives = 160/311 (51%), Gaps = 27/311 (8%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T + RY+ + +G G G V A D V + VAIK++ + + A RE+ L+K + Sbjct: 31 TSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKEL 90 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD--HERMSYLLYQMLCG 176 H+NII L +V + ++L+ E + +L + + D + LYQ++ G Sbjct: 91 QHRNIIELKSV------IHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLING 144 Query: 177 IKHLHSAGIIHRDLKPSNIVVK-SDCT----LKILDFGLARTAGTSF-MMTPYVVTRYYR 230 + HS +HRDLKP N+++ SD + LKI DFGLAR G T ++T +YR Sbjct: 145 VNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYR 204 Query: 231 APEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 PE++LG Y +VDIWS+ CI EM+ LFPG IDQ K+ E LG P Sbjct: 205 PPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPG 264 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + + ++ ++ PK+ G T ++ L + DLL+ ML +DP KRIS Sbjct: 265 VT-ALPDWKQSFPKFRGKTLKRVL-----------GALLDDEGLDLLTAMLEMDPVKRIS 312 Query: 350 VDDALQHPYIN 360 +AL+HPY + Sbjct: 313 AKNALEHPYFS 323 >3EB0-A nrPDB Length = 383 Score = 151 bits (381), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 111/353 (31%), Positives = 175/353 (49%), Gaps = 61/353 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T K+Y K +G+G+ GIVC +D + A+KK+ Q+ + R EL +MK + Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV---LQDPRYKNR---ELDIMKVL 57 Query: 119 NHKNIISLLNVF---------TPQK---------------------TLEEFQDVYL--VM 146 +H NII L++ F PQ + Q+ YL +M Sbjct: 58 DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIM 117 Query: 147 ELMDANLCQVIQMELDHER------MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS- 199 E + L +V++ + R +S +YQ+ + +HS GI HRD+KP N++V S Sbjct: 118 EYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 200 DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVR 258 D TLK+ DFG A+ S Y+ +R+YRAPE++LG Y ++D+WS+GC+ GE++ Sbjct: 178 DNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 259 HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR-PKYAGLTFPKLFPDSL 317 K LF G IDQ ++I+ +GTP E M ++ P +Y E R P + K+ P+ Sbjct: 238 GKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNP---HYTEVRFPTLKAKDWRKILPEG- 293 Query: 318 FPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEA 370 S A DLL ++L +P RI+ +A+ HP+ + + E E Sbjct: 294 ----------TPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEV 336 >3ZDU-A nrPDB Length = 325 Score = 149 bits (376), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 103/306 (33%), Positives = 159/306 (51%), Gaps = 27/306 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVN 119 ++ Y+ L +G G+ G V + VAIK RP Q+ K A RE+ +K + Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERP--EQSVNKIAMREIKFLKQFH 59 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCG 176 H+N+++L+ VF +K ++LV E +D + +Q L+ +R+ L+Q+L Sbjct: 60 HENLVNLIEVFRQKKK------IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRA 113 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEVI 235 I +LHS IIHRD+KP NI+V K+ DFG ART A + V TR+YRAPE++ Sbjct: 114 IDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELV 173 Query: 236 L-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 L Y + VDIW++GC++ EM P +D +K++ ++G L P + Sbjct: 174 LKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGN--------LSPHL 225 Query: 295 RNYVENRPKYAGLTFPKL-FPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 +N P +AG+ P++ P + A ++ KL A D++ L IDPA RIS D Sbjct: 226 QNIFSKSPIFAGVVLPQVQHPKN---ARKKYPKLNGLLA-DIVHACLQIDPADRISSSDL 281 Query: 354 LQHPYI 359 L H Y Sbjct: 282 LHHEYF 287 >1UA2-A nrPDB Length = 346 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 95/307 (30%), Positives = 162/307 (52%), Gaps = 28/307 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH---AKRAYRELVLMKCV 118 KRY+ L +G G V A D ++ VAIKK+ +++ + A RE+ L++ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLC 175 +H NII LL+ F + ++ LV + M+ +L +I+ + L + + L Sbjct: 70 SHPNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-SFMMTPYVVTRYYRAPEV 234 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ + T VVTR+YRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 235 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 + G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + + Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-S 242 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 + +YV + +FP + +F A + DL+ + + +P RI+ A Sbjct: 243 LPDYVTFK------SFPGIPLHHIFSAAGD-------DLLDLIQGLFLFNPCARITATQA 289 Query: 354 LQHPYIN 360 L+ Y + Sbjct: 290 LKMKYFS 296 >5G6V-A nrPDB Length = 324 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 95/306 (31%), Positives = 146/306 (47%), Gaps = 28/306 (9%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ Y L +G G V + D VA+K++ R + A RE+ L+K + H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI-RLEHEEGAPCTAIREVSLLKDLKH 59 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGI 177 NI++L ++ +K+L LV E +D +L Q + ++ + L+Q+L G+ Sbjct: 60 ANIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGL 113 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY---VVTRYYRAPEV 234 + H ++HRDLKP N+++ LK+ DFGLAR S Y VVT +YR P++ Sbjct: 114 AYCHRQKVLHRDLKPQNLLINERGELKLADFGLAR--AKSIPTKTYDNEVVTLWYRPPDI 171 Query: 235 ILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 +LG Y +D+W VGCI EM + LFPG +Q + + LGTP E + Sbjct: 172 LLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSN 231 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 N PKY A H S DLL+K+L + RIS +DA Sbjct: 232 EEFKTYNYPKYRA------------EALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDA 279 Query: 354 LQHPYI 359 ++HP+ Sbjct: 280 MKHPFF 285 >4KRC-A nrPDB Length = 317 Score = 138 bits (348), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 96/318 (30%), Positives = 152/318 (47%), Gaps = 29/318 (9%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 +++ L+ +G+G V + VA+K++ + T + A RE+ LMK + H+N Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPST-AIREISLMKELKHEN 64 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--------LDHERMSYLLYQML 174 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 65 IVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPE 233 G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP+ Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 234 VILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ- 291 V++G Y ++DIWS GCI+ EM+ K LFPG + +Q + + +GTP + Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 292 -PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 P ++ RP P+ L P E D L +L ++P R+S Sbjct: 239 LPKYNPNIQQRP-------PRDLRQVLQPHTKEP---LDGNLMDFLHGLLQLNPDMRLSA 288 Query: 351 DDALQHPYINVWYDPAEV 368 AL HP+ +Y A + Sbjct: 289 KQALHHPWFAEYYHHASM 306 >3E3P-A nrPDB Length = 360 Score = 137 bits (346), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 104/320 (32%), Positives = 163/320 (50%), Gaps = 30/320 (9%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + R+Q + G G G V + +VAIKK+ Q+ R + + + ++H Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHH 78 Query: 121 KNIISLLNVFTPQKTLEEF--QDVYL--VMELMDANLCQVIQMELDHE------RMSYLL 170 NI+ L + F TL E +D+YL VME + L + + + + L Sbjct: 79 PNIVQLQSYFY---TLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 171 YQML--CGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 +Q++ G HL S + HRD+KP N++V ++D TLK+ DFG A+ S Y+ +R Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSR 195 Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 YYRAPE+I G Y VDIWSVGCI EM+ + +F G + Q ++++ LG P E Sbjct: 196 YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREV 255 Query: 287 MKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 ++KL P+ + K G+ + +F S+H+ A +A DLLS +L P + Sbjct: 256 LRKLNPSHTDVDLYNSK--GIPWSNVF--------SDHSLKDAKEAYDLLSALLQYLPEE 305 Query: 347 RISVDDALQHPYINVWYDPA 366 R+ +AL HPY + +DPA Sbjct: 306 RMKPYEALCHPYFDELHDPA 325 >5AIR-A nrPDB Length = 430 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 96/315 (30%), Positives = 157/315 (49%), Gaps = 37/315 (11%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL--SRPFQNQTHAKRAYRELVLMKCVNHK 121 Y + K IG+G+ G+V A VAIKK+ + F+N REL +M+ ++H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDHC 117 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLL---------YQ 172 NI+ L F + E+ +VYL + ++D V ++ + R L YQ Sbjct: 118 NIVRLRYFF--YSSGEKKDEVYLNL-VLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQ 174 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 + + ++HS GI HRD+KP N+++ D LK+ DFG A+ Y+ +RYYRA Sbjct: 175 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 234 Query: 232 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PE+I G Y ++D+WS GC++ E++ + +FPG +DQ ++I+ LGTP E ++++ Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 294 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 P NY E FP++ P +A L S++L P R++ Sbjct: 295 NP---NYTE-------FKFPQI---KAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTP 341 Query: 351 DDALQHPYINVWYDP 365 +A H + + DP Sbjct: 342 LEACAHSFFDELRDP 356 >5EFQ-A nrPDB Length = 347 Score = 131 bits (330), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 93/322 (28%), Positives = 158/322 (49%), Gaps = 37/322 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G G V A D VA+KK+ + + A RE+ +++ + H++II++ + Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 130 FTPQKTLEEFQD----VYLVMELMDANLCQVIQMELDH---ERMSYLLYQMLCGIKHLHS 182 T ++ +F+ YLV E MD +L +++ L H + + Q++ G+ + H Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 138 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAPEVILG-MG 239 +HRD+K SNI++ + +K+ DFGLAR ++ S T V+T +YR PE++LG Sbjct: 139 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER 198 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y +D+WS GCI+GE+ K +F + Q + G+PCP + P V Sbjct: 199 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCP----AVWPDV----- 249 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKA------SQARDLLSKMLVIDPAKRISVDDA 353 + P + +++ P KL+ + A DL ML +DP+KR + + A Sbjct: 250 -------IKLP--YFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQA 300 Query: 354 LQHPYINVWYDPAEVEAPPPQI 375 LQ ++ D + PPP + Sbjct: 301 LQCEFLR---DVEPSKMPPPDL 319 >4AGU-A nrPDB Length = 311 Score = 130 bits (328), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 89/309 (28%), Positives = 149/309 (48%), Gaps = 30/309 (9%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++++Y+ + IG G+ G+V + + VAIKK + K A RE+ ++K + Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCG 176 H N+++LL VF ++ L +LV E D + + Q + + + +Q L Sbjct: 61 HPNLVNLLEVFRRKRRL------HLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQA 114 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-TAGTSFMMTPYVVTRYYRAPEVI 235 + H IHRD+KP NI++ +K+ DFG AR G S V TR+YR+PE++ Sbjct: 115 VNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELL 174 Query: 236 LG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 +G Y VD+W++GC+ E++ L+PG+ +DQ + + LG L P Sbjct: 175 VGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGD--------LIPRH 226 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLK----ASQARDLLSKMLVIDPAKRISV 350 + ++G+ P P D E +LK + A LL L +DP +R++ Sbjct: 227 QQVFSTNQYFSGVKIPD-------PEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTC 279 Query: 351 DDALQHPYI 359 + L HPY Sbjct: 280 EQLLHHPYF 288 >4NST-A nrPDB Length = 351 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 98/358 (27%), Positives = 167/358 (46%), Gaps = 37/358 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G G V A D VA+KK+ + + A RE+ +++ + H++++++ + Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEI 80 Query: 130 FTPQKTLEEFQD----VYLVMELMDANLCQVIQMELDH---ERMSYLLYQMLCGIKHLHS 182 T ++ +F+ YLV E MD +L +++ L H + + + Q++ G+++ H Sbjct: 81 VTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHK 140 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAPEVILG-MG 239 +HRD+K SNI++ + +K+ DFGLAR + S T V+T +YR PE++LG Sbjct: 141 KNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEER 200 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y +D+WS GCI+GE+ K +F + Q + G+PC P V V Sbjct: 201 YTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC--------PAVWPDVI 252 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P + + K + L E S A DLL ML +DP+KR + + LQ ++ Sbjct: 253 KLPYFNTMKPKKQYRRRL----REEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL 308 Query: 360 NVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417 D + PP + W++ + ++GVV +P PS Sbjct: 309 K---DVELSKMAPPD------------LPHWQDCHELWSKKRRRQRQSGVVVEEPPPS 351 >3MIA-A nrPDB Length = 351 Score = 128 bits (321), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 92/314 (29%), Positives = 151/314 (48%), Gaps = 23/314 (7%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H+N Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 123 IISLLNVFTPQKTLEEF--QDVYLVMELMD---ANLCQVIQMELDHERMSYLLYQMLCGI 177 +++L+ + + + +YLV + + A L + ++ + ++ +L G+ Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP-----YVVTRYYRAP 232 ++H I+HRD+K +N+++ D LK+ DFGLAR + P VVT +YR P Sbjct: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 233 EVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 E++LG Y +D+W GCIM EM + G Q + + G+ PE + Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE----VW 253 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 P V NY Y L K + D ++ A DL+ K+LV+DPA+RI D Sbjct: 254 PNVDNY----ELYEKLELVKGQKRKV--KDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 Query: 352 DALQHPYINVWYDP 365 DAL H + W DP Sbjct: 308 DALNHDFF--WSDP 319 >5JN2-A nrPDB Length = 525 Score = 125 bits (313), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 99/333 (29%), Positives = 153/333 (45%), Gaps = 47/333 (14%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAYRELVL 114 ST RY+ + +G G+ G V D + + A+K +S R + +T + RE+ L Sbjct: 61 STAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL 120 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQML 174 +K ++H NI+ L F + +VY EL D + + E+D R ++ Q+L Sbjct: 121 LKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAAR---IIRQVL 177 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 GI ++H I+HRDLKP N++++S D ++I+DFGL+ S M + T YY A Sbjct: 178 SGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIA 237 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 PEV+ G Y E D+WS G I+ IL G CP F + Sbjct: 238 PEVLHGT-YDEKCDVWSTGVIL------YILLSG-----------------CPPFNGANE 273 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 + VE + KY P+ K + A+DL+ KML P+ RIS Sbjct: 274 YDILKKVE-KGKYT-FELPQW-------------KKVSESAKDLIRKMLTYVPSMRISAR 318 Query: 352 DALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 DAL H +I Y ++ P + + L+ R+ Sbjct: 319 DALDHEWIQT-YTKEQISVDVPSLDNAILNIRQ 350 >3MA6-A nrPDB Length = 298 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 96/314 (30%), Positives = 145/314 (46%), Gaps = 46/314 (14%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAYRE 111 V ST RY+ + +G G+ G V D + + A+K +S R + +T + RE Sbjct: 23 VQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLRE 82 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY 171 + L+K ++H NI+ L F + +VY EL D + + E+D R ++ Sbjct: 83 VQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAAR---IIR 139 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRY 228 Q+L GI ++H I+HRDLKP N++++S D ++I+DFGL+ S M + T Y Sbjct: 140 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY 199 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y APEV+ G Y E D+WS G I+ IL G CP F Sbjct: 200 YIAPEVLHGT-YDEKCDVWSTGVIL------YILLSG-----------------CPPFNG 235 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 + + VE + KY P+ K + A+DL+ KML P+ RI Sbjct: 236 ANEYDILKKVE-KGKYT-FELPQW-------------KKVSESAKDLIRKMLTYVPSMRI 280 Query: 349 SVDDALQHPYINVW 362 S DAL H +I + Sbjct: 281 SARDALDHEWIQTY 294 >4IAN-A nrPDB Length = 358 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 100/339 (29%), Positives = 163/339 (48%), Gaps = 36/339 (10%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTHAK 106 +Y V +G+ + KRY G G V A D A ++ VA+K + N+ K Sbjct: 19 YYRVNIGE---VLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQK 72 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MEL 161 +EL +K +N + + + Q + LV E + NL +V++ + L Sbjct: 73 TGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 132 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMM 220 + + Q+ +K L I+H D+KP NI+V +S LK+ DFG A + + Sbjct: 133 HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADN-DI 191 Query: 221 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 TPY+V+R+YRAPE+I+G Y +D+WSVGC + E+ KILFPG+ ++ G Sbjct: 192 TPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 251 Query: 281 TPCPEFMKKLQPTVRNYVEN-------------RPKYAGLTFPKLFPDSLFPAD------ 321 + ++K +++ +N R K ++ + P AD Sbjct: 252 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMS--TINPTKDLLADLIGCQR 309 Query: 322 -SEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 E + K Q +DLL ++L++DPAKRIS++ ALQH +I Sbjct: 310 LPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFI 348 >4RGJ-A nrPDB Length = 520 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 102/348 (29%), Positives = 157/348 (45%), Gaps = 53/348 (15%) Query: 39 MSKSKVDNQFYSVE------VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAI 92 +SK V+N F + + + +S ++Y+ +K +G G+ G V + D AI Sbjct: 31 ISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAI 90 Query: 93 KKLSRP-FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA 151 K +S+ + +T + RE+ L+K ++H NI+ L F DVY EL D Sbjct: 91 KVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDE 150 Query: 152 NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILD 207 + + E+D R ++ Q+L GI ++H ++HRDLKP NI++ K D +KI+D Sbjct: 151 IISRKRFYEIDAAR---IIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIID 207 Query: 208 FGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD 267 FGL+ S M + T YY AP+V+ G Y E DIWS G I+ IL G Sbjct: 208 FGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVIL------YILLSG-- 258 Query: 268 YIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKL 327 CP F + + VE KY P+ K Sbjct: 259 ---------------CPPFNGSNEYDILKKVE-AGKYT-FDLPQF-------------KK 288 Query: 328 KASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQI 375 + +A+DL+ KML+ A RIS DAL+H +I + + P + Sbjct: 289 ISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSL 336 >4CRL-A nrPDB Length = 406 Score = 121 bits (303), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 88/291 (30%), Positives = 141/291 (48%), Gaps = 57/291 (19%) Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--------- 158 A RE+ L++ + H N+ISL VF + V+L+ + + +L +I+ Sbjct: 66 ACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKANK 121 Query: 159 --MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD----CTLKILDFGLAR 212 ++L + LLYQ+L GI +LH+ ++HRDLKP+NI+V + +KI D G AR Sbjct: 122 KPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR 181 Query: 213 TAGTSFM----MTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRD 267 + + P VVT +YRAPE++LG Y + +DIW++GCI E++ + +F R Sbjct: 182 LFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQ 241 Query: 268 ---------YIDQWNKVIEQLGTPC----------PEFMKKLQPTVRNYVENRPKYAGLT 308 + DQ +++ +G P PE ++ RN N + Sbjct: 242 EDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME 301 Query: 309 FPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K+ PD S+A LL K+L +DP KRI+ + A+Q PY Sbjct: 302 KHKVKPD--------------SKAFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >5Y86-A nrPDB Length = 588 Score = 120 bits (302), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 155/322 (48%), Gaps = 30/322 (9%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 RY+ LK IG G+ G V YD L + VA+K + + ++A E+ +++ + ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQD 264 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIK 178 +NV ++ V + EL+ +L ++I+ + + +L + Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 179 HLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 LH IIH DLKP NI++K + K++DFG + + Y+ +R+YRAPE+IL Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTYIQSRFYRAPEIIL 382 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 G Y +DIWS GCI+ E++ + LFPG D DQ ++E LG P P+ +++ + + Sbjct: 383 GSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSK-RAKY 441 Query: 297 YVENR--PKYAGLTFPKLFPDSLFPADSEHNKLKASQAR----------------DLLSK 338 ++ ++ P+Y +T L S K + + L + Sbjct: 442 FINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKR 501 Query: 339 MLVIDPAKRISVDDALQHPYIN 360 L DP+ R++ AL+HP+I+ Sbjct: 502 CLHWDPSARLTPAQALRHPWIS 523 >5ZTN-A nrPDB Length = 429 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 93/324 (28%), Positives = 158/324 (48%), Gaps = 30/324 (9%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 V RY+ LK IG G+ G V AYD + ++VA+K + + ++A E+ +++ + Sbjct: 95 VAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLR 151 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLC 175 ++ + +NV + + + EL+ NL ++I+ + + +L Sbjct: 152 KQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ 211 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 + LH IIH DLKP NI++K +K++DFG + + Y+ +R+YRAPE Sbjct: 212 CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTYIQSRFYRAPE 269 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 VILG Y +D+WS+GCI+ E++ L PG D DQ +IE LG P + + + Sbjct: 270 VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK-R 328 Query: 294 VRNYVENR--PKYAGLTFPKLFPDSLFPADSEHNKLKA-SQAR---------------DL 335 +N+V ++ P+Y +T L S KL+ ++R D Sbjct: 329 AKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDF 388 Query: 336 LSKMLVIDPAKRISVDDALQHPYI 359 L + L DPA R++ AL+HP++ Sbjct: 389 LKQCLEWDPAVRMTPGQALRHPWL 412 >3LIJ-A nrPDB Length = 494 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 94/302 (31%), Positives = 144/302 (47%), Gaps = 51/302 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 YQ +K +GSGA G V D V AIK + + + + + E+ ++K ++H NI Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVI-QMELDHERMSYLLYQMLCGIKHL 180 + L + F E+ ++ YLVME ++I +M+ + + ++ Q+L G+ +L Sbjct: 99 MKLYDFF------EDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYL 152 Query: 181 HSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 H I+HRDLKP N++++S D +KI+DFGL+ M + T YY APEV L Sbjct: 153 HKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEV-LR 211 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y E D+WS+G I+ IL G P F + + Sbjct: 212 KKYDEKCDVWSIGVILF------ILLAG-----------------YPPFGGQTDQEILRK 248 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 VE + KY TF DS K + A+DL+ +ML D +RIS AL+HP Sbjct: 249 VE-KGKY---TF-----------DSPEWKNVSEGAKDLIKQMLQFDSQRRISAQQALEHP 293 Query: 358 YI 359 +I Sbjct: 294 WI 295 >3NCG-A nrPDB Length = 486 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 88/307 (28%), Positives = 138/307 (44%), Gaps = 45/307 (14%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T +RY + +G G+ G V D + + A+K +++ RE+ L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI+ L + + ++Y EL D + + E D R ++ Q+ GI Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAAR---IIKQVFSGIT 135 Query: 179 HLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 ++H I+HRDLKP NI+++S DC +KI+DFGL+ + M + T YY APEV+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y E D+WS G I+ IL G P F K + + Sbjct: 196 RGT-YDEKCDVWSAGVIL------YILLSG-----------------TPPFYGKNEYDIL 231 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 VE KYA P+ + + A+DL+ KML P+ RI+ L+ Sbjct: 232 KRVET-GKYA-FDLPQW-------------RTISDDAKDLIRKMLTFHPSLRITATQCLE 276 Query: 356 HPYINVW 362 HP+I + Sbjct: 277 HPWIQKY 283 >2YCR-A nrPDB Length = 323 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 91/310 (29%), Positives = 153/310 (49%), Gaps = 63/310 (20%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA------YRELVLMKCVNHK 121 K +GSGA G V A++ + VAIK +S+ A+ A E+ ++K +NH Sbjct: 16 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 75 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCG 176 II + N F + +D Y+V+ELM+ ++ + ++R+ YQML Sbjct: 76 CIIKIKNFF-------DAEDYYIVLELMEGG--ELFDKVVGNKRLKEATCKLYFYQMLLA 126 Query: 177 IKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 +++LH GIIHRDLKP N+++ S DC +KI DFG ++ G + +M T Y APE Sbjct: 127 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPE 186 Query: 234 VILGM---GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 V++ + GY VD WS+G I+ I G P P + Sbjct: 187 VLVSVGTAGYNRAVDCWSLGVIL---------------------FICLSGYP-PFSEHRT 224 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Q ++++ + + KY + P+++ + + +A DL+ K+LV+DP R + Sbjct: 225 QVSLKDQITS-GKYNFI--PEVWAEV------------SEKALDLVKKLLVVDPKARFTT 269 Query: 351 DDALQHPYIN 360 ++AL+HP++ Sbjct: 270 EEALRHPWLQ 279 >3I6U-A nrPDB Length = 419 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 97/342 (28%), Positives = 168/342 (49%), Gaps = 67/342 (19%) Query: 38 NMSKSKVDNQFYSVEVGDSTF---TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK 94 ++S++KV F+ + V D + + Y K +GSGA G V A++ + VAI+ Sbjct: 109 SLSRNKV-FVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRI 167 Query: 95 LSRPFQNQTHAKRA------YRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 +S+ A+ A E+ ++K +NH II + N F + +D Y+V+EL Sbjct: 168 ISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-------DAEDYYIVLEL 220 Query: 149 MDANLCQVIQMELDHERMS-----YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---D 200 M+ ++ + ++R+ YQML +++LH GIIHRDLKP N+++ S D Sbjct: 221 MEGG--ELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEED 278 Query: 201 CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM---GYKENVDIWSVGCIMGEMV 257 C +KI DFG ++ G + +M T Y APEV++ + GY VD WS+G I+ Sbjct: 279 CLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVIL---- 334 Query: 258 RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSL 317 I G P P + Q ++++ + + KY + P+++ + Sbjct: 335 -----------------FICLSGYP-PFSEHRTQVSLKDQITS-GKYNFI--PEVWAEV- 372 Query: 318 FPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + +A DL+ K+LV+DP R + ++AL+HP++ Sbjct: 373 -----------SEKALDLVKKLLVVDPKARFTTEEALRHPWL 403 >3DFA-A nrPDB Length = 286 Score = 116 bits (290), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 88/304 (28%), Positives = 136/304 (44%), Gaps = 45/304 (14%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T +RY + +G G+ G V D + + A+K +++ RE+ L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI+ L + + ++Y EL D + + E D R ++ Q+ GI Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAAR---IIKQVFSGIT 135 Query: 179 HLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 ++H I+HRDLKP NI+++S DC +KI+DFGL+ + M + T YY APEV+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y E D+WS G I+ IL G P F K + + Sbjct: 196 RGT-YDEKCDVWSAGVIL------YILLSG-----------------TPPFYGKNEYDIL 231 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 VE KYA D + + A+DL+ KML P+ RI+ L+ Sbjct: 232 KRVET-GKYA--------------FDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLE 276 Query: 356 HPYI 359 HP+I Sbjct: 277 HPWI 280 >2WO6-A nrPDB Length = 382 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 100/334 (29%), Positives = 151/334 (45%), Gaps = 45/334 (13%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK--KLSRPFQNQTHAKRAYRELVLMKCV 118 + RY+ IG G+ G V AYD V VAIK K + F NQ E+ L++ + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI-----EVRLLELM 107 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ------MELDHERMSYLLYQ 172 N + + ++ + LV E++ NL +++ + L+ R Q Sbjct: 108 NKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRK--FAQQ 165 Query: 173 MLCGIKHLHS--AGIIHRDLKPSNIVV--KSDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 M + L + IIH DLKP NI++ +KI+DFG + G + Y+ +R+ Sbjct: 166 MCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR--IYQYIQSRF 223 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 YR+PEV+LGM Y +D+WS+GCI+ EM + LF G + +DQ NK++E LG P P + Sbjct: 224 YRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP-PAHIL 282 Query: 289 KLQPTVRNYVENRP--------------KYAGLTFPKLF---------PDSLFPADSEHN 325 P R + E P +Y KL P +S H Sbjct: 283 DQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHT 342 Query: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + +DL+ +ML DP RI ALQH + Sbjct: 343 VADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 376 >3HZT-A nrPDB Length = 467 Score = 111 bits (277), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 92/301 (30%), Positives = 138/301 (45%), Gaps = 46/301 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHK 121 RYQ +K +GSGA G V D + AIK + + T A E+ ++K ++H Sbjct: 5 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 64 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 181 NI+ L F ++ +VY EL D + + E+D + ++ Q+L G +LH Sbjct: 65 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVD---AAVIMKQVLSGTTYLH 121 Query: 182 SAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 I+HRDLKP N++++S D +KI+DFGL+ M + T YY APEV L Sbjct: 122 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV-LRK 180 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 Y E D+WS G I+ IL G P F + + V Sbjct: 181 KYDEKCDVWSCGVIL------YILLCGY-----------------PPFGGQTDQEILKRV 217 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 E + K+ S P D + +A+ L+ ML +P+KRIS ++AL HP+ Sbjct: 218 E-KGKF-----------SFDPPDWTQ---VSDEAKQLVKLMLTYEPSKRISAEEALNHPW 262 Query: 359 I 359 I Sbjct: 263 I 263 >5X8I-B nrPDB Length = 346 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 97/336 (28%), Positives = 157/336 (46%), Gaps = 53/336 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 RY+ + +G GA G V D R+VA+K + + A R+ ++ + H Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVK-IVKNVDRYCEAARSE-----IQVLEHL 67 Query: 122 NIISLLNVFTPQKTLEEFQD---VYLVMELMDANLCQVIQ------MELDHERMSYLLYQ 172 N + F + LE F+ + +V EL+ + I+ LDH R + YQ Sbjct: 68 NTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRK--MAYQ 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIV-VKSDCT------------------LKILDFGLART 213 + + LHS + H DLKP NI+ V+SD T +K++DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 185 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 + V TR+YRAPEVIL +G+ + D+WS+GCI+ E +FP D + Sbjct: 186 DDEHH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHL- 242 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKY-----AGLTFPKL---FPDSLFPADSEHN 325 ++E++ P P+ M + + + +R + AG + + + D EH Sbjct: 243 AMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHE 302 Query: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 +L DL+ KML DPAKRI++ +AL+HP+ ++ Sbjct: 303 RL-----FDLIQKMLEYDPAKRITLREALKHPFFDL 333 >4YZB-A nrPDB Length = 491 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 91/310 (29%), Positives = 140/310 (45%), Gaps = 46/310 (14%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAYRELVL 114 ST RY+ + +G G+ G V D V + A+K +S R + +T + +E+ L Sbjct: 24 STAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVEL 83 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQML 174 +K ++H NI+ L F + +VY EL D + + E+D R ++ Q+L Sbjct: 84 LKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAAR---IIRQVL 140 Query: 175 CGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 GI ++H I+HRDLKP N+++ + D ++I+DFGL+ ++ M + T YY A Sbjct: 141 SGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIA 200 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 PEV+ G Y E D+WS G I+ IL G CP F + Sbjct: 201 PEVLHGT-YDEKCDVWSTGVIL------YILLSG-----------------CPPFNGANE 236 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 + VE F D K + A+DL+ KML P RIS Sbjct: 237 FDILKKVEK---------------GKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISAR 281 Query: 352 DALQHPYINV 361 DAL+H ++ Sbjct: 282 DALEHEWLKT 291 >3DXN-A nrPDB Length = 287 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 92/301 (30%), Positives = 137/301 (45%), Gaps = 46/301 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHK 121 RYQ +K +GSGA G V D + AIK + + T A E+ ++K ++H Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHP 81 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 181 NI+ L F ++ +VY EL D + + E+D + ++ Q+L G +LH Sbjct: 82 NIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVD---AAVIMKQVLSGTTYLH 138 Query: 182 SAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 I+HRDLKP N++++S D +KI+DFGL+ M + T YY APEV L Sbjct: 139 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEV-LRK 197 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 Y E D+WS G I+ IL G P F + + V Sbjct: 198 KYDEKCDVWSCGVIL------YILLCGY-----------------PPFGGQTDQEILKRV 234 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 E +F PD +D +A+ L+ ML +P+KRIS ++AL HP+ Sbjct: 235 EK----GKFSFDP--PDWTQVSD---------EAKQLVKLMLTYEPSKRISAEEALNHPW 279 Query: 359 I 359 I Sbjct: 280 I 280 >5ES1-A nrPDB Length = 328 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 82/312 (26%), Positives = 138/312 (44%), Gaps = 56/312 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ L+ IG G V A + R VAIK + + N + ++ +RE+ +MK +NH NI Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIK 178 + L V +KTL YLVME A +V + H RM Q++ + Sbjct: 77 VKLFEVIETEKTL------YLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAVH 128 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 + H I+HRDLK N+++ ++ +KI DFG + + + + Y APE+ G Sbjct: 129 YCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGK 188 Query: 239 GYKE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y VDIWS+G I+ +V + F G + +K+L+ V Sbjct: 189 KYDGPEVDIWSLGVILYTLVSGSLPFDGHN-------------------LKELRERVLRG 229 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 P Y ++ +L + LV++PAKR +++ ++ Sbjct: 230 KYRVPFYM-----------------------STDCESILRRFLVLNPAKRCTLEQIMKDK 266 Query: 358 YINVWYDPAEVE 369 +IN+ Y+ E++ Sbjct: 267 WINIGYEGEELK 278 >6FYV-A nrPDB Length = 337 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 99/336 (29%), Positives = 157/336 (46%), Gaps = 53/336 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLD-RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 RY+ + +G GA G V D +D +VA+K + +N + A R + + + H Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV----KNVGRYREAARSEI--QVLEHL 68 Query: 122 NIISLLNVFTPQKTLEEFQD---VYLVMELMDANLCQVIQ------MELDHERMSYLLYQ 172 N +VF + LE F V +V EL+ + I+ ++DH R + YQ Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQ--MAYQ 126 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIV-VKSD------------------CTLKILDFGLART 213 + I LH + H DLKP NI+ VKSD +K++DFG A Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 186 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 + V TR+YRAPEVIL +G+ + D+WS+GCI+ E +F D + Sbjct: 187 DDEHH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHL- 243 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKY-----AGLTFP---KLFPDSLFPADSEHN 325 ++E++ P P+ M + + + N+ + AG K + + D EH Sbjct: 244 AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHE 303 Query: 326 KLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 KL DL+ +ML DP +RI++D+ALQHP+ ++ Sbjct: 304 KL-----FDLVRRMLEYDPTQRITLDEALQHPFFDL 334 >2QNJ-A nrPDB Length = 328 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 80/281 (28%), Positives = 129/281 (45%), Gaps = 35/281 (12%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ LK IG G V A + R VAIK + + N T ++ +RE+ +MK +NH NI Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIK 178 + L V +KTL YL+ME A+ +V + H RM Q++ ++ Sbjct: 74 VKLFEVIETEKTL------YLIMEY--ASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQ 125 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 + H I+HRDLK N+++ +D +KI DFG + + + + Y APE+ G Sbjct: 126 YCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 185 Query: 239 GYKE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-------LGTPCPEFMKK- 289 Y VD+WS+G I+ +V + F G++ + +V+ + T C +K+ Sbjct: 186 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRF 245 Query: 290 --LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLK 328 L P R T ++ D A E ++LK Sbjct: 246 LVLNPIKRG-----------TLEQIMKDRWINAGHEEDELK 275 >4MVF-A nrPDB Length = 506 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/298 (28%), Positives = 142/298 (47%), Gaps = 53/298 (17%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +G G G V D V ++ AIK+ + + R ++E+ +MK ++H NI+ L Sbjct: 63 EKLGQGTYGCVYKGIDKVTNQLYAIKEEKK--DRLKNINRFFQEIEIMKKLDHPNIVKLY 120 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQM-ELDHERMSYLLYQMLCGIKHLHSAG 184 +T E +YL+MEL +I+ + + ++ Q+ I +LHS Sbjct: 121 ------ETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 185 IIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK 241 I+HRDLKP N + +S D LKI+DFGL++ GT T T YY AP+V+ G Y Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK-YD 233 Query: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 + DIWS G IM ++ F G D N+V +KK++ + EN Sbjct: 234 KKCDIWSSGVIMYTLLCGYPPFYG----DTDNEV-----------LKKVKKGEFCFYEN- 277 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + + +S A++L++K+L +P +R ++++AL HP+I Sbjct: 278 -DWGSI---------------------SSDAKNLITKLLTYNPNERCTIEEALNHPWI 313 >2F57-A nrPDB Length = 317 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 143/304 (47%), Gaps = 50/304 (16%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 N IG G+ GIVC A + + VA+KK+ + Q + + E+V+M+ +H N++ Sbjct: 49 NFIKIGEGSTGIVCIATEKHTGKQVAVKKMD--LRKQQRRELLFNEVVIMRDYHHDNVVD 106 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIQMELDHERMSYLLYQMLCGIKHLHSA 183 + + + L ++VME ++ V ++ E+++ + +L + +LH+ Sbjct: 107 MYSSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 160 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 G+IHRD+K +I++ SD +K+ DFG A+ + V T Y+ APEVI + Y Sbjct: 161 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 220 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VDIWS+G ++ EM+ G P P F N P Sbjct: 221 EVDIWSLGIMVIEMID---------------------GEP-PYF-------------NEP 245 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + + DSL P + +K+ +S R L MLV +P++R + + L HP++ + Sbjct: 246 PLQAM---RRIRDSLPPRVKDLHKV-SSVLRGFLDLMLVREPSQRATAQELLGHPFLKLA 301 Query: 363 YDPA 366 P+ Sbjct: 302 GPPS 305 >5XVU-A nrPDB Length = 332 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 91/327 (27%), Positives = 161/327 (49%), Gaps = 23/327 (7%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 N+ K K ++Y + + + RY+ +K IG G V YD +R AIK L Sbjct: 10 NIHKPK---EYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKP 66 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 157 + + + +L NII LL++ T + L+ E ++ + + Sbjct: 67 VKKKKIKREIK----ILQNLNGGPNIIKLLDIVKDPVT----KTPSLIFEYINNIDFKTL 118 Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGT 216 + + + Y +YQ+L + + HS GI+HRD+KP NI++ + ++++ +GLA Sbjct: 119 YPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHP 178 Query: 217 SFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNK 274 V +RYY+ PE+++ + Y ++DIWS+GC++ M+ + + F G D DQ K Sbjct: 179 GQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVK 238 Query: 275 VIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAG-LTFPKLFPDSLFPADSEHNKLKASQA 332 + + LGT + L ++ Y ++ +P Y L + P S F S + + + Sbjct: 239 IAKVLGT------EDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNID-IAKDEV 291 Query: 333 RDLLSKMLVIDPAKRISVDDALQHPYI 359 DL+ KML+ D AKRI+ +A++HPY Sbjct: 292 IDLIDKMLIYDHAKRIAPKEAMEHPYF 318 >4FIE-A nrPDB Length = 423 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 142/306 (46%), Gaps = 50/306 (16%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 N IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ Sbjct: 155 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 212 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIQMELDHERMSYLLYQMLCGIKHLHSA 183 + N + ++++VME ++ V ++ E+++ + +L + LH+ Sbjct: 213 MYNSYL------VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 266 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 267 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 326 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VDIWS+G ++ EMV G P P F N P Sbjct: 327 EVDIWSLGIMVIEMVD---------------------GEP-PYF-------------NEP 351 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + K+ D+L P +K+ S + L ++LV DPA+R + + L+HP++ Sbjct: 352 PLKAM---KMIRDNLPPRLKNLHKVSPS-LKGFLDRLLVRDPAQRATAAELLKHPFLAKA 407 Query: 363 YDPAEV 368 PA + Sbjct: 408 GPPASI 413 >4XBR-A nrPDB Length = 366 Score = 105 bits (261), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 141/306 (46%), Gaps = 50/306 (16%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 N IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ Sbjct: 98 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 155 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIQMELDHERMSYLLYQMLCGIKHLHSA 183 + N + L ++VME ++ V ++ E+++ + +L + LH+ Sbjct: 156 MYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 209 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 210 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 269 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VDIWS+G ++ EMV G P P F N P Sbjct: 270 EVDIWSLGIMVIEMVD---------------------GEP-PYF-------------NEP 294 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + K+ D+L P +K+ S + L ++LV DPA+R + + L+HP++ Sbjct: 295 PLKAM---KMIRDNLPPRLKNLHKVSPS-LKGFLDRLLVRDPAQRATAAELLKHPFLAKA 350 Query: 363 YDPAEV 368 PA + Sbjct: 351 GPPASI 356 >5KZ7-A nrPDB Length = 346 Score = 105 bits (261), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 74/252 (29%), Positives = 122/252 (48%), Gaps = 24/252 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ LK IG G V A + + VA+K + + N + ++ +RE+ +MK +NH NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIK 178 + L V +KTL YLVME A+ +V + H RM Q++ ++ Sbjct: 95 VKLFEVIETEKTL------YLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 146 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 + H I+HRDLK N+++ +D +KI DFG + + + + Y APE+ G Sbjct: 147 YCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 206 Query: 239 GYKE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-------LGTPCPEFMKK- 289 Y VD+WS+G I+ +V + F G++ + +V+ + T C +KK Sbjct: 207 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKF 266 Query: 290 --LQPTVRNYVE 299 L P+ R +E Sbjct: 267 LILNPSKRGTLE 278 >2Q0N-A nrPDB Length = 301 Score = 104 bits (260), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 141/306 (46%), Gaps = 50/306 (16%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 N IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ Sbjct: 33 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 90 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIQMELDHERMSYLLYQMLCGIKHLHSA 183 + N + L ++VME ++ V ++ E+++ + +L + LH+ Sbjct: 91 MYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 144 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 145 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 204 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VDIWS+G ++ EMV G P P F N P Sbjct: 205 EVDIWSLGIMVIEMVD---------------------GEP-PYF-------------NEP 229 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + K+ D+L P +K+ S + L ++LV DPA+R + + L+HP++ Sbjct: 230 PLKAM---KMIRDNLPPRLKNLHKVSPS-LKGFLDRLLVRDPAQRATAAELLKHPFLAKA 285 Query: 363 YDPAEV 368 PA + Sbjct: 286 GPPASI 291 >4JDH-A nrPDB Length = 346 Score = 104 bits (260), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 141/306 (46%), Gaps = 50/306 (16%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 N IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ Sbjct: 78 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVE 135 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIQMELDHERMSYLLYQMLCGIKHLHSA 183 + N + L ++VME ++ V ++ E+++ + +L + LH+ Sbjct: 136 MYNSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQ 189 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 G+IHRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y Sbjct: 190 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGP 249 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VDIWS+G ++ EMV G P P F N P Sbjct: 250 EVDIWSLGIMVIEMVD---------------------GEP-PYF-------------NEP 274 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + K+ D+L P +K+ S + L ++LV DPA+R + + L+HP++ Sbjct: 275 PLKAM---KMIRDNLPPRLKNLHKVSPS-LKGFLDRLLVRDPAQRATAAELLKHPFLAKA 330 Query: 363 YDPAEV 368 PA + Sbjct: 331 GPPASI 336 >4EQM-A nrPDB Length = 294 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 74/211 (35%), Positives = 114/211 (54%), Gaps = 12/211 (5%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVNH 120 +RY+ + +G G V A D +L+ VAIK + P + + KR RE+ ++H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGI 177 +NI+S+++V EE YLVME ++ L + I+ L + Q+L GI Sbjct: 71 QNIVSMIDVD------EEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGI 124 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVV-TRYYRAPEVI 235 KH H I+HRD+KP NI++ S+ TLKI DFG+A+ + TS T +V+ T Y +PE Sbjct: 125 KHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQA 184 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGR 266 G E DI+S+G ++ EM+ + F G Sbjct: 185 KGEATDECTDIYSIGIVLYEMLVGEPPFNGE 215 >6C9D-A nrPDB Length = 459 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 67/219 (30%), Positives = 108/219 (49%), Gaps = 14/219 (6%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K IG G V A + R VA+K + + N T ++ +RE+ +MK +NH NI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIK 178 + L V +KTL YLVME A+ +V + H RM Q++ ++ Sbjct: 83 VKLFEVIETEKTL------YLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 134 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 + H I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Sbjct: 135 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGK 194 Query: 239 GYKE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 Y VD+WS+G I+ +V + F G++ + +V+ Sbjct: 195 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL 233 >2PVN-A nrPDB Length = 352 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 69/246 (28%), Positives = 126/246 (51%), Gaps = 22/246 (8%) Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 181 NI+ LL++ Q + + L+ E ++ +V+ L + Y +Y++L + + H Sbjct: 108 NIVKLLDIVRDQHS----KTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCH 163 Query: 182 SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM-G 239 S GI+HRD+KP N+++ + L+++D+GLA V +RY++ PE+++ + Sbjct: 164 SQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQD 223 Query: 240 YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP-----CPEFMKKLQPT 293 Y ++D+WS+GC+ M+ R + F G D DQ K+ + LGT ++ +L P Sbjct: 224 YDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQ 283 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 + V + L F AD++H L + +A D L K+L D +R++ +A Sbjct: 284 LEALVGRHSRKPWLKF--------MNADNQH--LVSPEAIDFLDKLLRYDHQERLTALEA 333 Query: 354 LQHPYI 359 + HPY Sbjct: 334 MTHPYF 339 >3KN6-A nrPDB Length = 325 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 133/292 (45%), Gaps = 52/292 (17%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK-CVNHKNIISL 126 KP+G G+ I ++ A+K +S+ + T +E+ +K C H NI+ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ-----KEITALKLCEGHPNIVKL 71 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGIKHLHSA 183 VF Q +LVMEL++ L + I+ + SY++ +++ + H+H Sbjct: 72 HEVFHDQ------LHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 125 Query: 184 GIIHRDLKPSNIVV---KSDCTLKILDFGLARTA--GTSFMMTPYVVTRYYRAPEVILGM 238 G++HRDLKP N++ + +KI+DFG AR + TP T +Y APE++ Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTP-CFTLHYAAPELLNQN 184 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 GY E+ D+WS+G I+ M+ ++ F D T E MKK++ Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHDR--------SLTCTSAVEIMKKIKK------ 230 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 F + E K + +A+DL+ +L +DP KR+ + Sbjct: 231 -----------------GDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKM 265 >2JD5-A nrPDB Length = 373 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 93/350 (26%), Positives = 163/350 (46%), Gaps = 41/350 (11%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH-- 120 RY ++ +G G V A D V + +VA+K + ++ + + A E+ L++ VN Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 121 ---------KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY 171 +I+ LL+ F + V +V E++ NL +I+ + +H + L+Y Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIK-KYEHRGIP-LIY 132 Query: 172 ------QMLCGIKHLHS-AGIIHRDLKPSNIVVK------SDCTLKILDFGLARTAGTSF 218 Q+L G+ ++H GIIH D+KP N++++ + +KI D G A + Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHY 192 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF---PGRDYI---DQW 272 T + TR YR+PEV+LG + DIWS C++ E++ LF G Y D Sbjct: 193 --TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHI 250 Query: 273 NKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFP-DSLFPADSEHNKLKASQ 331 ++IE LG P ++ + R + +R ++ K +P + + + +K +A + Sbjct: 251 AQIIELLGE-LPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 332 ARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLD 381 D LS ML +DP KR + HP++ E+ P ++Y D Sbjct: 310 ISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSD 359 >4NIF-A nrPDB Length = 333 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 74/257 (28%), Positives = 124/257 (48%), Gaps = 51/257 (19%) Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHER-MSYL 169 +L++ H NII+L +V+ ++ + VYLV ELM L ++++ + ER S++ Sbjct: 54 ILLRYGQHPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV 107 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC----TLKILDFGLART--AGTSFMMTPY 223 L+ + +++LHS G++HRDLKPSNI+ + L+I DFG A+ A +MTP Sbjct: 108 LHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTP- 166 Query: 224 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 T + APEV+ GY E DIWS+G ++ M+ F D +++ ++G+ Sbjct: 167 CYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGS-- 223 Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 F + + A+DL+SKML +D Sbjct: 224 --------------------------------GKFTLSGGNWNTVSETAKDLVSKMLHVD 251 Query: 344 PAKRISVDDALQHPYIN 360 P +R++ LQHP++ Sbjct: 252 PHQRLTAKQVLQHPWVT 268 >2HAK-A nrPDB Length = 328 Score = 101 bits (251), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 67/219 (30%), Positives = 108/219 (49%), Gaps = 14/219 (6%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K IG G V A + R VA+K + + N T ++ +RE+ +MK +NH NI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIK 178 + L V +KTL YLVME A+ +V + H RM Q++ ++ Sbjct: 77 VKLFEVIETEKTL------YLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 128 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 + H I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Sbjct: 129 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGK 188 Query: 239 GYKE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 Y VD+WS+G I+ +V + F G++ + +V+ Sbjct: 189 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVL 227 >4KS7-A nrPDB Length = 292 Score = 99.4 bits (246), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 82/294 (27%), Positives = 134/294 (45%), Gaps = 52/294 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G+ GIVC A + R VA+K + + Q + + E+V+M+ H N++ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLFNEVVIMRDYQHFNVVEMYKS 88 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQ--VIQMELDHERMSYLLYQMLCGIKHLHSAGIIH 187 + + L +++ME + V Q+ L+ E+++ + +L + +LH+ G+IH Sbjct: 89 YLVGEEL------WVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIH 142 Query: 188 RDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDI 246 RD+K +I++ D +K+ DFG A+ + V T Y+ APEVI Y VDI Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDI 202 Query: 247 WSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAG 306 WS+G ++ EMV G P P F ++ ++ P Sbjct: 203 WSLGIMVIEMVD---------------------GEP-PYFSDSPVQAMKRLRDSPP---- 236 Query: 307 LTFPKLFPDSLFPADSEHNKLKASQA-RDLLSKMLVIDPAKRISVDDALQHPYI 359 PKL N K S RD L +MLV DP +R + + L HP++ Sbjct: 237 ---PKL-----------KNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >6HMD-A nrPDB Length = 365 Score = 98.6 bits (244), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 120/225 (53%), Gaps = 20/225 (8%) Query: 144 LVMELMD-ANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDC 201 LV E ++ + Q+ Q+ D + + + +Y++L + + HS GI+HRD+KP N+++ Sbjct: 127 LVFEYINNTDFKQLYQILTDFD-IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQK 185 Query: 202 TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV-RH 259 L+++D+GLA + V +RY++ PE+++ Y ++D+WS+GC++ M+ R Sbjct: 186 KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRR 245 Query: 260 KILFPGRDYIDQWNKVIEQLGT-PCPEFMKK----LQPTVRNYVENRPKYAGLTFPKLFP 314 + F G+D DQ ++ + LGT ++KK L P + + + F Sbjct: 246 EPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF----- 300 Query: 315 DSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 SE+ L + +A DLL K+L D +R++ +A++HPY Sbjct: 301 -----IHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >6O6Q-A nrPDB Length = 335 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/317 (25%), Positives = 155/317 (48%), Gaps = 39/317 (12%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK-CVNHKN 122 Y+ L+ +G G V D V IK L +P + K+ RE+ ++K V+ N Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVL-KPVKR----KKIKREISILKNLVDGPN 97 Query: 123 IISLLNVF------TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCG 176 II++L+V TP E ++ + + D++ + + +Y++L Sbjct: 98 IIAMLDVVREPQSKTPGLIFEHINNI---------DFRSLYPTFTDYD-IRFYMYELLKA 147 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + + HS GI+HRD+KP N+++ D L+++D+GLA V +RY++ PE++ Sbjct: 148 LDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELL 207 Query: 236 LGMG-YKENVDIWSVGCIMGEMVRHKI-LFPGRDYIDQWNKVIEQLGTP-CPEFMKKLQP 292 + Y ++D+WS GC++ MV K F G+ DQ +++ LG+ ++++K Sbjct: 208 VDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNI 267 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNK-LKASQARDLLSKMLVIDPAKRISVD 351 ++ E+ Y + + +E+NK L + + DL+ ++L D +R++ Sbjct: 268 SLGEEYEDIGYYNKRQWVRFM--------NENNKDLVSQEFLDLIDRLLRYDHQERLTAK 319 Query: 352 DALQHPYINVWYDPAEV 368 +A++H Y +DP V Sbjct: 320 EAMKHAY----FDPIRV 332 >3Q5I-A nrPDB Length = 504 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 69/219 (31%), Positives = 112/219 (51%), Gaps = 31/219 (14%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQG--IVCAAYDAVLDRNVAIKKLSRPFQN-------- 101 ++G+S F V K +GSGA G ++C + ++ + + K S+ + Sbjct: 33 KIGESYFKVRK-------LGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKN 85 Query: 102 -QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVI- 157 + + Y E+ L+K ++H NII L +VF +K YLV E + Q+I Sbjct: 86 IEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYF------YLVTEFYEGGELFEQIIN 139 Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLARTA 214 + + D + ++ Q+L GI +LH I+HRD+KP NI++++ +L KI+DFGL+ Sbjct: 140 RHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFF 199 Query: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM 253 + + + T YY APEV L Y E D+WS G IM Sbjct: 200 SKDYKLRDRLGTAYYIAPEV-LKKKYNEKCDVWSCGVIM 237 >5XZW-A nrPDB Length = 471 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 83/308 (26%), Positives = 133/308 (43%), Gaps = 63/308 (20%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V A + + A+K +S+ + + REL +++ +NH I+ L Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262 Query: 130 FTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGII 186 + E+ + Y+VME + +L + + + + Q+L IK++HS GI Sbjct: 263 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 316 Query: 187 HRDLKPSNIVVKSD--CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG----- 239 HRDLKP NI+++ D +KI DFGLA+ G M + T Y APEVI G Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 376 Query: 240 --------YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 Y VD+WS+GC++ ++ + F G +++ +Q+G Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----STQDQLYKQIGRG--------- 423 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 +Y E P F E ARD + +L +DP R + Sbjct: 424 ----SYHEG-------------PLKDFRISEE--------ARDFIDSLLQVDPNNRSTAA 458 Query: 352 DALQHPYI 359 AL HP+I Sbjct: 459 KALNHPWI 466 >3H4J-B nrPDB Length = 336 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 82/299 (27%), Positives = 133/299 (44%), Gaps = 58/299 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCVNHKNIISLLN 128 +G G+ G V A + VA+K +SR ++ R RE+ +K + H +II L + Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS-----YLLYQMLCGIKHLHSA 183 V T D+ +V+E L I ++ +RM+ Q++C I++ H Sbjct: 77 VITTP------TDIVMVIEYAGGELFDYI---VEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE- 242 I+HRDLKP N+++ + +KI DFGL+ + + Y APEVI G Y Sbjct: 128 KIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VD+WS G ++ M+ ++ F D++ P KK+ V YV Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFD-----DEF----------IPNLFKKVNSCV--YV---- 226 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 PD L P A+ L+ +M+V DP +RI++ + + P+ NV Sbjct: 227 ----------MPDFLSPG-----------AQSLIRRMIVADPMQRITIQEIRRDPWFNV 264 >6FD3-A nrPDB Length = 300 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 54/314 (17%) Query: 51 VEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR 110 V VGD K+Y + IG GA G V A D + VAIK+++ Q Q + Sbjct: 15 VSVGDPK----KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIIN 68 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME-LMDANLCQVI-QMELDHERMSY 168 E+++M+ + NI++ L+ + L ++VME L +L V+ + +D +++ Sbjct: 69 EILVMRENKNPNIVNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAA 122 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTR 227 + + L + LHS +IHRD+K NI++ D ++K+ DFG A+ + V T Sbjct: 123 VCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTP 182 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y+ APEV+ Y VDIWS+G + EMV + + + + +I GTP Sbjct: 183 YWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTP----- 236 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 +LQ P+ F RD L++ L +D +R Sbjct: 237 -ELQ---------NPERLSAVF-----------------------RDFLNRCLEMDVDRR 263 Query: 348 ISVDDALQHPYINV 361 S + LQHP++ + Sbjct: 264 GSAKELLQHPFLKL 277 >6EII-A nrPDB Length = 352 Score = 95.1 bits (235), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 117/221 (52%), Gaps = 12/221 (5%) Query: 144 LVME-LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC- 201 LV E + + + Q+ Q D++ + + +Y++L + + HS GI+HRD+KP N+++ + Sbjct: 134 LVFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 192 Query: 202 TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV-RH 259 L+++D+GLA V +RY++ PE+++ Y ++D+WS+GC++ M+ R Sbjct: 193 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 252 Query: 260 KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLF 318 + F G D DQ ++ + LGT + L + Y +E P++ + Sbjct: 253 EPFFHGHDNYDQLVRIAKVLGT------EDLYDYIDKYNIELDPRFNDILGRHSRKRWER 306 Query: 319 PADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 SE+ L + +A D L K+L D R++ +A++HPY Sbjct: 307 FVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >4JG6-A nrPDB Length = 355 Score = 94.7 bits (234), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 74/260 (28%), Positives = 124/260 (47%), Gaps = 53/260 (20%) Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHER-MSYL 169 +L++ H NII+L +V+ K VY+V ELM L ++++ + ER S + Sbjct: 81 ILLRYGQHPNIITLKDVYDDGKY------VYVVTELMKGGELLDKILRQKFFSEREASAV 134 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC----TLKILDFGLART--AGTSFMMTPY 223 L+ + +++LH+ G++HRDLKPSNI+ + +++I DFG A+ A +MTP Sbjct: 135 LFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP- 193 Query: 224 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP-GRDYIDQWNKVIEQLGTP 282 T + APEV+ GY DIWS+G ++ M+ F G D D +++ ++G+ Sbjct: 194 CYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD--DTPEEILARIGS- 250 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 F + + A+DL+SKML + Sbjct: 251 ---------------------------------GKFSLSGGYWNSVSDTAKDLVSKMLHV 277 Query: 343 DPAKRISVDDALQHPYINVW 362 DP +R++ L+HP+I W Sbjct: 278 DPHQRLTAALVLRHPWIVHW 297 >4FG9-A nrPDB Length = 320 Score = 94.4 bits (233), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 82/296 (27%), Positives = 135/296 (45%), Gaps = 51/296 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G+GA V A D + VAIK +++ E+ ++ + H NI++L ++ Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME-NEIAVLHKIKHPNIVALDDI 84 Query: 130 FTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHER-MSYLLYQMLCGIKHLHSAGII 186 + E +YL+M+L+ ++++ ER S L++Q+L +K+LH GI+ Sbjct: 85 Y------ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138 Query: 187 HRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 HRDLKP N++ S D + I DFGL++ +++ T Y APEV+ Y + Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKA 198 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPK 303 VD WS+G I IL G P F Y EN K Sbjct: 199 VDCWSIGVIA------YILLCGY-----------------PPF----------YDENDAK 225 Query: 304 YAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 F ++ + + DS + + A+D + ++ DP KR + + ALQHP+I Sbjct: 226 ----LFEQILK-AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >3Q53-A nrPDB Length = 306 Score = 94.4 bits (233), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 68/223 (30%), Positives = 115/223 (51%), Gaps = 16/223 (7%) Query: 39 MSKSKVDNQFYS-VEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 MS ++ + S V VGD K+Y + IG GA G V A D + VAI++++ Sbjct: 1 MSDEEILEKLRSIVSVGDPK----KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN- 55 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME-LMDANLCQV 156 Q Q + E+++M+ + NI++ L+ + L ++VME L +L V Sbjct: 56 -LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDEL------WVVMEYLAGGSLTDV 108 Query: 157 I-QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTA 214 + + +D +++ + + L ++ LHS +IHRD+K NI++ D ++K+ DFG A+ Sbjct: 109 VTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 168 Query: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 + V T Y+ APEV+ Y VDIWS+G + EM+ Sbjct: 169 PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMI 211 >4MD7-E nrPDB Length = 391 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 61/225 (27%), Positives = 116/225 (51%), Gaps = 20/225 (8%) Query: 144 LVME-LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC- 201 LV E + + + Q+ Q D++ + + +Y++L + + HS GI+HRD+KP N+++ + Sbjct: 111 LVFEHVNNTDFKQLYQTLTDYD-IRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169 Query: 202 TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV-RH 259 L+++D+GLA V +RY++ PE+++ Y ++D+WS+GC++ M+ R Sbjct: 170 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229 Query: 260 KILFPGRDYIDQWNKVIEQLGTP-----CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFP 314 + F G D DQ ++ + LGT ++ +L P + + + F Sbjct: 230 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERF----- 284 Query: 315 DSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 SE+ L + +A D L K+L D R++ +A++HPY Sbjct: 285 -----VHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >3BHH-A nrPDB Length = 295 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 131/300 (43%), Gaps = 45/300 (15%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 YQ + IG GA +V A K ++ + ++ RE + + + H NI Sbjct: 6 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 65 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 + L + + + D+ EL + + + E D S+ + Q+L + H H Sbjct: 66 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILEAVLHCHQM 122 Query: 184 GIIHRDLKPSNIVVKSDC---TLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMG 239 G++HRDLKP N+++ S C +K+ DFGLA G + T Y +PEV+ Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEA 182 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y + VDIW+ G I+ IL G P F + Q + + Sbjct: 183 YGKPVDIWACGVIL------YILLVGY-----------------PPFWDEDQHKLYQQI- 218 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K FP D++ P +A++L+++ML I+PAKRI+ +AL+HP++ Sbjct: 219 ---KAGAYDFPSPEWDTVTP-----------EAKNLINQMLTINPAKRITAHEALKHPWV 264 >2V7O-A nrPDB Length = 336 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 133/300 (44%), Gaps = 45/300 (15%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 YQ + +G GA +V + A K ++ + ++ RE + + + H NI Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 92 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 + L + + + D+ EL + + + E D S+ ++Q+L + H+H Sbjct: 93 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEAD---ASHCIHQILESVNHIHQH 149 Query: 184 GIIHRDLKPSNIVVKSDC---TLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMG 239 I+HRDLKP N+++ S C +K+ DFGLA G + T Y +PEV+ Sbjct: 150 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDP 209 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y + VDIW+ G I+ IL G P F + Q + + Sbjct: 210 YGKPVDIWACGVIL------YILLVGY-----------------PPFWDEDQHKLYQQI- 245 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K FP D++ P +A++L+++ML I+PAKRI+ D AL+HP++ Sbjct: 246 ---KAGAYDFPSPEWDTVTP-----------EAKNLINQMLTINPAKRITADQALKHPWV 291 >2VZ6-A nrPDB Length = 313 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/315 (25%), Positives = 137/315 (43%), Gaps = 45/315 (14%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 V++G YQ + +G GA +V + + A K ++ + ++ Sbjct: 10 GVDLGTENLYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE 69 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 RE + + + H NI+ L + + + D+ EL + + + E D S+ Sbjct: 70 REARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD---ASHC 126 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVV 225 + Q+L + H H G++HRDLKP N+++ S +K+ DFGLA G + Sbjct: 127 IQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAG 186 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y +PEV+ Y + VD+W+ G I+ IL G P Sbjct: 187 TPGYLSPEVLRKDPYGKPVDLWACGVIL------YILLVGY-----------------PP 223 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 F + Q + + K FP D++ P +A+DL++KML I+P+ Sbjct: 224 FWDEDQHRLYQQI----KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPS 268 Query: 346 KRISVDDALQHPYIN 360 KRI+ +AL+HP+I+ Sbjct: 269 KRITAAEALKHPWIS 283 >3DLS-A nrPDB Length = 335 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 102/207 (49%), Gaps = 17/207 (8%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP------FQNQTHAKRAYRELVLM 115 ++Y + P+GSGA G V A D ++ V +K + + + + E+ ++ Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLY 171 V H NII +L++F Q + LVME + L ++ LD SY+ Sbjct: 84 SRVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR 137 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 Q++ + +L IIHRD+K NIV+ D T+K++DFG A + + T Y A Sbjct: 138 QLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197 Query: 232 PEVILGMGYK-ENVDIWSVGCIMGEMV 257 PEV++G Y+ +++WS+G + +V Sbjct: 198 PEVLMGNPYRGPELEMWSLGVTLYTLV 224 >5U6Y-A nrPDB Length = 461 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 133/301 (44%), Gaps = 45/301 (14%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 YQ + +G GA +V + + A K ++ + ++ RE + + + H NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 + L + + + D+ EL + + + E D S+ + Q+L + H H Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILEAVLHCHQM 118 Query: 184 GIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMG 239 G++HRDLKP N+++ S +K+ DFGLA G + T Y +PEV+ Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y + VD+W+ G I+ IL G P F + Q + + Sbjct: 179 YGKPVDLWACGVIL------YILLVGY-----------------PPFWDEDQHRLYQQI- 214 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K FP D++ P +A+DL++KML I+P+KRI+ +AL+HP+I Sbjct: 215 ---KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPSKRITAAEALKHPWI 260 Query: 360 N 360 + Sbjct: 261 S 261 >4PDS-A nrPDB Length = 347 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 81/310 (26%), Positives = 133/310 (42%), Gaps = 63/310 (20%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V A + + ++K +S+ + + REL +++ +NH I+ L Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKLNHPRIVRLKGF 97 Query: 130 FTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGII 186 + E+ + Y+VME + +L + + + + Q+L IK++HS GI Sbjct: 98 Y------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGIS 151 Query: 187 HRDLKPSNIVVKSD--CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG----- 239 HRDLKP NI+++ D +KI FGLA+ G M + T Y APEVI G Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSP 211 Query: 240 --------YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 Y VD+WS+GC++ ++ + F G +++ +Q+G Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----STQDQLYKQIGRG--------- 258 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 +Y E P F E ARD + +L +DP R + Sbjct: 259 ----SYHEG-------------PLKDFRISEE--------ARDFIDSLLQVDPNNRSTAA 293 Query: 352 DALQHPYINV 361 AL HP+I + Sbjct: 294 KALNHPWIKM 303 >4I6B-A nrPDB Length = 308 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 80/321 (24%), Positives = 138/321 (42%), Gaps = 61/321 (19%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK-----KLSRPFQNQTHAKRAYRELV 113 T KRY K +G G D ++ A K ++S+P Q + + +E+ Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQRE----KIDKEIE 80 Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLL 170 L + ++HK+++ + F E+ +++Y+++E ++ +++ L + Y L Sbjct: 81 LHRILHHKHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYL 134 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYY 229 Q++ G+K+LH I+HRDLK N + LK+ DFGL AR T Y Sbjct: 135 RQIVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNY 194 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 +PEV+ G+ DIW++GC+M M+ LG P P Sbjct: 195 LSPEVLNKQGHGAESDIWALGCVMYTML---------------------LGRP-PFETTN 232 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 L+ T R+ E R P SL + A+ L++ ML +P R S Sbjct: 233 LKETYRSIREAR---------YTMPSSLL-----------APAKHLIASMLSKNPEDRPS 272 Query: 350 VDDALQHPYINVWYDPAEVEA 370 +DD ++H + + P + + Sbjct: 273 LDDIIRHDFFTQGFTPDRLSS 293 >6E2O-A nrPDB Length = 295 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 6/198 (3%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G GIV A D +AIK++ P ++ +++ + E+ L K + HKNI+ L Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRD 189 F+ ++ F + L + ++ + + + + Q+L G+K+LH I+HRD Sbjct: 88 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 190 LKPSNIVVKS-DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILG--MGYKENVD 245 +K N+++ + LKI DFG + R AG + + T Y APE+I GY + D Sbjct: 148 IKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAAD 207 Query: 246 IWSVGCIMGEMVRHKILF 263 IWS+GC + EM K F Sbjct: 208 IWSLGCTIIEMATGKPPF 225 >2WQN-A nrPDB Length = 310 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 79/245 (32%), Positives = 122/245 (49%), Gaps = 30/245 (12%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA--YREL 112 D + L ++ K IG G V A + VA+KK+ + F RA +E+ Sbjct: 25 DMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKV-QIFDLMDAKARADCIKEI 83 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVI-----QMELDHERM 166 L+K +NH N+I F E ++ +V+EL DA +L ++I Q L ER Sbjct: 84 DLLKQLNHPNVIKYYASFI------EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERT 137 Query: 167 SYLLYQMLC-GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR------TAGTSFM 219 + + LC ++H+HS ++HRD+KP+N+ + + +K+ D GL R TA S + Sbjct: 138 VWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV 197 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN--KVIE 277 TP YY +PE I GY DIWS+GC++ EM + F G D ++ ++ K IE Sbjct: 198 GTP-----YYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYG-DKMNLYSLCKKIE 251 Query: 278 QLGTP 282 Q P Sbjct: 252 QCDYP 256 >5IG1-A nrPDB Length = 344 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 91/346 (26%), Positives = 144/346 (41%), Gaps = 69/346 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG GA V + A+K ++ + + RE+ + + H++I+S+ Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 130 FTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHER-MSYLLYQMLCGIKHLHSAGII 186 F + YLV E + +++ + +E+ S ++Q+L ++H HS II Sbjct: 85 FRDESHF------YLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 187 HRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 HRDLKP N+++ S + +KI DFGLA + T Y +PEVI + Y Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYDTA 198 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPK 303 VD+W+ G I+ IL G Y W E +KL ++N Sbjct: 199 VDVWACGVIL------YILLVG--YPPFWE-----------EDHQKLYAQIKN------- 232 Query: 304 YAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWY 363 FP DS+ A A++L+ ML +P +R +V + LQHP+I Sbjct: 233 -CQYDFPSPEWDSVTTA-----------AKELIKAMLEPNPKRRPTVQELLQHPWIARRD 280 Query: 364 DPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGV 409 P V R+ T+EE K+ N+ K K GV Sbjct: 281 VPGSV-------------HRQATLEELKKF------NARRKLKGGV 307 >2VN9-A nrPDB Length = 301 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 131/300 (43%), Gaps = 45/300 (15%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 YQ + +G GA +V + A K ++ + ++ RE + + + H NI Sbjct: 6 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 65 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 + L + + + D+ EL + + + E D S+ + Q+L + H H Sbjct: 66 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILESVNHCHLN 122 Query: 184 GIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMG 239 GI+HRDLKP N+++ S +K+ DFGLA G + T Y +PEV+ Sbjct: 123 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDP 182 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y + VD+W+ G I+ IL G P F + Q + + Sbjct: 183 YGKPVDMWACGVIL------YILLVGY-----------------PPFWDEDQHRLYQQI- 218 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K FP D++ P +A+DL++KML I+PAKRI+ +AL+HP+I Sbjct: 219 ---KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPAKRITASEALKHPWI 264 >5UNP-A nrPDB Length = 369 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 71/245 (28%), Positives = 113/245 (46%), Gaps = 42/245 (17%) Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKSDCTL------------------KI 205 ++ ++ +Q+ +K LH + H DLKP NI+ V SD L ++ Sbjct: 139 QVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRV 198 Query: 206 LDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265 +DFG A + V TR+YRAPEVIL +G+ + D+WS+GCI+ E LF Sbjct: 199 VDFGSATFDHEH--HSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQT 256 Query: 266 RDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFP--------KLFPDSL 317 D + ++E++ P P M + + + R + T K L Sbjct: 257 HDNREHL-AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYL 315 Query: 318 FPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPP-QIY 376 EH++L DL+ ML +PAKR+++ +ALQHP+ A + A PP +++ Sbjct: 316 TSEAEEHHQLF-----DLIESMLEYEPAKRLTLGEALQHPFF------ARLRAEPPNKLW 364 Query: 377 DKQLD 381 D D Sbjct: 365 DSSRD 369 >2W4O-A nrPDB Length = 349 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 81/298 (27%), Positives = 135/298 (45%), Gaps = 55/298 (18%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKCVNHKNIISLLN 128 +G GA IV + A+K L + T K+ R E+ ++ ++H NII L Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKK-----TVDKKIVRTEIGVLLRLSHPNIIKLKE 115 Query: 129 VFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHER-MSYLLYQMLCGIKHLHSAGI 185 +F E ++ LV+EL+ ++++ ER + + Q+L + +LH GI Sbjct: 116 IF------ETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGI 169 Query: 186 IHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 +HRDLKP N++ + D LKI DFGL++ +M T Y APE++ G Y Sbjct: 170 VHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGP 229 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 VD+WSVG ++ + +L + D+ +FM + Y Sbjct: 230 EVDMWSVG-----IITYILLCGFEPFYDERGD----------QFMFRRILNCEYY----- 269 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 F + D + + A+DL+ K++V+DP KR++ ALQHP++ Sbjct: 270 ------FISPWWDEV-----------SLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >3RAW-A nrPDB Length = 381 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 79/331 (23%), Positives = 141/331 (42%), Gaps = 45/331 (13%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 +RY+ + +G G G V D ++ K+ R A R E+ ++K + K Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARL--EINVLKKIKEK 108 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDHERMSYLLYQMLC 175 + + + + EL+ N + ++ L H R ++ YQ+ Sbjct: 109 DKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVR--HMAYQLCH 166 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKS-------------------DCTLKILDFGLARTAGT 216 ++ LH + H DLKP NI+ + + ++++ DFG A Sbjct: 167 ALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHE 226 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 T V TR+YR PEVIL +G+ + D+WS+GCI+ E R LF + + ++ Sbjct: 227 H--HTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL-VMM 283 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADS--------EHNKLK 328 E++ P P M + + + GL + + D + ++ + L+ Sbjct: 284 EKILGPIPSHMIHRTRKQKYFYK-----GGLVWDENSSDGRYVKENCKPLKSYMLQDSLE 338 Query: 329 ASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 Q DL+ +ML DPA+RI++ +AL HP+ Sbjct: 339 HVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >6QAU-A nrPDB Length = 280 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 61/197 (30%), Positives = 101/197 (51%), Gaps = 20/197 (10%) Query: 70 IGSGAQGIVCAA-YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G GA +V + D VAIK +++ +++ +E+ ++K + H+NI++L + Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLG-KEIKILKELQHENIVALYD 77 Query: 129 VFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGI 185 V E V+LVME + +L +Q + L + + L+Q+ ++ LHS GI Sbjct: 78 V------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 131 Query: 186 IHRDLKPSNIVVK---------SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 IHRDLKP NI++ S +KI DFG AR ++ M + Y APEVI+ Sbjct: 132 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIM 191 Query: 237 GMGYKENVDIWSVGCIM 253 Y D+WS+G ++ Sbjct: 192 SQHYDAKADLWSIGTVI 208 >2Z7Q-A nrPDB Length = 321 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/238 (26%), Positives = 112/238 (47%), Gaps = 36/238 (15%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL--------- 114 ++ LK +G G+ G V ++K++RP +A + ++ L Sbjct: 30 FELLKVLGQGSFGKV-----------FLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK 78 Query: 115 -----MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERM 166 + VNH ++ L F + L YL+++ + +L + E E + Sbjct: 79 MERDILADVNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDV 132 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVV 225 + L ++ G+ HLHS GII+RDLKP NI++ + +K+ DFGL++ A + Sbjct: 133 KFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCG 192 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE-QLGTP 282 T Y APEV+ G+ + D WS G +M EM+ + F G+D + +++ +LG P Sbjct: 193 TVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 >1ZXE-A nrPDB Length = 303 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 66/221 (29%), Positives = 108/221 (48%), Gaps = 30/221 (13%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ + +G GA G V A +A+ R AIKK+ + E++L+ +NH+ + Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR---HTEEKLSTILSEVMLLASLNHQYV 64 Query: 124 ISLL-------NVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-LDHERMSY--LLYQ 172 + N P +++ +++ ME + L +I E L+ +R Y L Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---------------GTS 217 +L + ++HS GIIHR+LKP NI + +KI DFGLA+ G+S Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 218 FMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMV 257 +T + T Y A EV+ G G Y E +D++S+G I EM+ Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 225 >6CCF-A nrPDB Length = 290 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 86/330 (26%), Positives = 144/330 (43%), Gaps = 74/330 (22%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS------------RPFQNQTHA--- 105 L +Y+ IG GA G+V AY+ DR+ A+K LS RP + A Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 106 ---------KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV 156 +R Y+E+ ++K ++H N++ L+ V ++YLV +L+ Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVME 119 Query: 157 IQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RT 213 + + E+ L ++ G+++LH I+HRD+KPSN+++ D +KI DFG++ + Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYK---ENVDIWSVGCIMGEMVRHKILFPGRDYID 270 G ++ T + APE I G + +D+W+ G + V K F ID Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-----ID 234 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 +F+ L ++N P +FP+ P SE Sbjct: 235 --------------DFILALHRKIKNE------------PVVFPEE--PEISE------- 259 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYIN 360 + +DL+ KML +P RI V D HP++ Sbjct: 260 ELKDLILKMLDKNPETRIGVPDIKLHPWVT 289 >2JC6-A nrPDB Length = 334 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 83/321 (25%), Positives = 146/321 (45%), Gaps = 58/321 (18%) Query: 52 EVGDSTFTVLKRYQNLKPI-------GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 E G+S+ + K+ +++K I G+GA V A + + A+K + + Sbjct: 5 ENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE 64 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELD 162 + E+ +++ + H+NI++L +++ E +YLVM+L+ ++++ Sbjct: 65 SS-IENEIAVLRKIKHENIVALEDIY------ESPNHLYLVMQLVSGGELFDRIVEKGFY 117 Query: 163 HER-MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSF 218 E+ S L+ Q+L + +LH GI+HRDLKP N++ S + + I DFGL++ G Sbjct: 118 TEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD 177 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 +M+ T Y APEV+ Y + VD WS+G I IL G Sbjct: 178 VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIA------YILLCG------------- 218 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 P F Y EN K F ++ + + DS + + A+D + Sbjct: 219 ----YPPF----------YDENDSK----LFEQILK-AEYEFDSPYWDDISDSAKDFIRN 259 Query: 339 MLVIDPAKRISVDDALQHPYI 359 ++ DP KR + + A +HP+I Sbjct: 260 LMEKDPNKRYTCEQAARHPWI 280 >4B6L-A nrPDB Length = 281 Score = 88.2 bits (217), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 80/314 (25%), Positives = 132/314 (42%), Gaps = 63/314 (20%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK-----KLSRPFQNQTHAKRAYRELVLMK 116 + Y + +G G A D A+K ++++P Q + + E+ L + Sbjct: 9 RTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQRE----KILNEIELHR 64 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHERMSYLLYQ 172 + H++I+ + F E+ ++Y+ +EL A++ + L+ E + Y L Q Sbjct: 65 DLQHRHIVRFSHHF------EDADNIYIFLELCSRKSLAHIWKARHTLLEPE-VRYYLRQ 117 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRA 231 +L G+K+LH GI+HRDLK N + + LK+ DFGL AR T Y A Sbjct: 118 ILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVA 177 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 PEV+L G+ D+WS+GC+M ++ F D + + + I+Q+ P Sbjct: 178 PEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETY-RCIKQVHYTLP------- 229 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 A L+ P AR LL+ +L P R S+D Sbjct: 230 -------------ASLSLP---------------------ARQLLAAILRASPRDRPSID 255 Query: 352 DALQHPYINVWYDP 365 L+H + Y P Sbjct: 256 QILRHDFFTKGYTP 269 >4APC-A nrPDB Length = 350 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 104/212 (49%), Gaps = 12/212 (5%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F +++Y L+ IG G+ G R IK+++ + + + RE+ ++ Sbjct: 20 FQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN 79 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LDHERMSYLLYQ 172 + H NI+ +++ EE +Y+VM+ + +L + I + +++ Q Sbjct: 80 MKHPNIVQY------RESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQ 133 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV-TRYYRA 231 + +KH+H I+HRD+K NI + D T+++ DFG+AR ++ + + T YY + Sbjct: 134 ICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLS 193 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILF 263 PE+ Y DIW++GC++ E+ K F Sbjct: 194 PEICENKPYNNKSDIWALGCVLYELCTLKHAF 225 >2HW6-A nrPDB Length = 307 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 89/312 (28%), Positives = 138/312 (44%), Gaps = 53/312 (16%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISLLN 128 +G GA V A + A+K + + Q R +RE+ L +C +KNI+ L+ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 129 VFTPQKTLEEFQDVYLVME-LMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGI 185 F E+ YLV E L ++ IQ + + S ++ + + LH+ GI Sbjct: 79 FF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 186 IHRDLKPSNIVVKSD---CTLKILDF----GLARTAGTSFMMTPYVVT----RYYRAPEV 234 HRDLKP NI+ +S +KI DF G+ + + TP + T Y APEV Sbjct: 133 AHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEV 192 Query: 235 I-----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID-QWNKVIEQLGTPCPEFMK 288 + Y + D+WS+G ++ M+ F G D W++ G C Sbjct: 193 VEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDR-----GEVCRVCQN 247 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 KL +++ KY FPD D H +S+A+DL+SK+LV D +R+ Sbjct: 248 KLFESIQE-----GKYE-------FPDK----DWAH---ISSEAKDLISKLLVRDAKQRL 288 Query: 349 SVDDALQHPYIN 360 S LQHP++ Sbjct: 289 SAAQVLQHPWVQ 300 >4M7I-A nrPDB Length = 299 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 108/225 (48%), Gaps = 32/225 (14%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L ++ ++ +G G G+V A + V D N AIK++ P + ++ RE+ + + H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEH 62 Query: 121 KNIISLLNVFTPQKTLEEFQ----DVYLVMELMDANLCQVIQM-----------ELDHER 165 I+ N + + T E+ Q VYL +++ LC+ + E + Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQM---QLCRKENLKDWMNGRCTIEERERSV 119 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA----RTAGTSFMMT 221 ++ Q+ ++ LHS G++HRDLKPSNI D +K+ DFGL + ++T Sbjct: 120 CLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 222 PY---------VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 P V T+ Y +PE I G Y VDI+S+G I+ E++ Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL 224 >3SOA-A nrPDB Length = 444 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 76/303 (25%), Positives = 133/303 (43%), Gaps = 45/303 (14%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + YQ + +G GA +V + + A ++ + ++ RE + + + H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 181 NI+ L + + + D+ EL + + + E D S+ + Q+L + H H Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEAD---ASHCIQQILEAVLHCH 127 Query: 182 SAGIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILG 237 G++HR+LKP N+++ S +K+ DFGLA G + T Y +PEV+ Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y + VD+W+ G I+ IL G P F + Q + Sbjct: 188 DPYGKPVDLWACGVIL------YILLVGY-----------------PPFWDEDQHRLYQQ 224 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 + K FP D++ P +A+DL++KML I+P+KRI+ +AL+HP Sbjct: 225 I----KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPSKRITAAEALKHP 269 Query: 358 YIN 360 +I+ Sbjct: 270 WIS 272 >5JZN-A nrPDB Length = 280 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/316 (27%), Positives = 143/316 (45%), Gaps = 66/316 (20%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKC 117 T+ +RY+ + IG G +V + R A+K + + + + H + E+ +++ Sbjct: 16 TITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQ--NEVSILRR 73 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDH-ER-MSYLLYQML 174 V H NI+ L+ + ++ ++YLVMEL+ +L I + ER S +LY + Sbjct: 74 VKHPNIVLLI------EEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLA 127 Query: 175 CGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILDFGLARTAGTSFMMTPYVV--TRY 228 IK+LHS I+HRD+KP N++V +LK+ DFGLA Y V T Sbjct: 128 SAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPL----YTVCGTPT 183 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF----PGRDYIDQWNKVIEQLGTPCP 284 Y APE+I GY VDIW+ G I IL P R D + +Q+ Sbjct: 184 YVAPEIIAETGYGLKVDIWAAGVIT------YILLCGFPPFRGSGDDQEVLFDQI----- 232 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 M ++ FP + D++ + A++L++ ML++D Sbjct: 233 -LMGQVD-----------------FPSPYWDNV-----------SDSAKELITMMLLVDV 263 Query: 345 AKRISVDDALQHPYIN 360 +R S L+HP++N Sbjct: 264 DQRFSAVQVLEHPWVN 279 >3MN3-A nrPDB Length = 271 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 134/313 (42%), Gaps = 54/313 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCVNHKN 122 YQ +K +G G+ G V AY + VA+K +++ ++ + R RE+ ++ + H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHL 180 II L +V + ++ +V+E L I + ++ + Q++ +++ Sbjct: 66 IIKLYDVIKSK------DEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H I+HRDLKP N+++ +KI DFGL+ + + Y APEVI G Y Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 241 KE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 VD+WS G I+ M+ ++ F E + L + N V Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFDD-------------------ESIPVLFKNISNGVY 220 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 PK+ L P A L+ +ML+++P RIS+ + +Q + Sbjct: 221 TLPKF------------LSPG-----------AAGLIKRMLIVNPLNRISIHEIMQDDWF 257 Query: 360 NVWYDPAEVEAPP 372 V D E PP Sbjct: 258 KV--DLPEYLLPP 268 >5FG8-A nrPDB Length = 285 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 70/323 (21%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQT 103 DN E+G F+++KR + G AA + + KKL+ R FQ Sbjct: 14 DNYDIKEELGKGAFSIVKR------CVQKSTGFEFAA------KIINTKKLTARDFQKLE 61 Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL 161 R R+L +H NI+ L +++E YLV +L+ ++ E Sbjct: 62 REARICRKL------HHPNIVRL------HDSIQEENYHYLVFDLVTGGELFEDIVAREF 109 Query: 162 DHER-MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGT 216 E S+ + Q+L + H H G++HRDLKP N+++ S +K+ DFGLA G Sbjct: 110 YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGD 169 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 + T Y +PEV+ Y ++VDIW+ G I+ IL G Sbjct: 170 HQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVIL------YILLVGY---------- 213 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 336 P F + Q + + + K +P D++ P +A++L+ Sbjct: 214 -------PPFWDEDQHRLYSQI----KAGAYDYPSPEWDTVTP-----------EAKNLI 251 Query: 337 SKMLVIDPAKRISVDDALQHPYI 359 ++ML ++P KRI+ +AL+HP+I Sbjct: 252 NQMLTVNPNKRITAAEALKHPWI 274 >3IS5-A nrPDB Length = 285 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 84/307 (27%), Positives = 134/307 (43%), Gaps = 67/307 (21%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +GSGA G V + IK +++ ++Q ++ E+ ++K ++H NII + Sbjct: 28 RKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHPNIIKIF 86 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQME-----LDHERMSYLLYQMLCGIKHL 180 VF E++ ++Y+VME + L +++ + L ++ L+ QM+ + + Sbjct: 87 EVF------EDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 181 HSAGIIHRDLKPSNIVVKSD---CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 HS ++H+DLKP NI+ + +KI+DFGLA + T T Y APEV Sbjct: 141 HSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEV--- 197 Query: 238 MGYKENV----DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 +K +V DIWS G +M ++ + F GT E +K Sbjct: 198 --FKRDVTFKCDIWSAGVVMYFLLTGCLPFT---------------GTSLEEVQQKATYK 240 Query: 294 VRNY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 NY VE RP L P QA DLL +ML DP +R S Sbjct: 241 EPNYAVECRP---------LTP----------------QAVDLLKQMLTKDPERRPSAAQ 275 Query: 353 ALQHPYI 359 L H + Sbjct: 276 VLHHEWF 282 >4LFI-A nrPDB Length = 374 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 63/256 (24%), Positives = 123/256 (48%), Gaps = 30/256 (11%) Query: 120 HKNIISLLNVF------TPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQM 173 H NII L ++ TP LV E +D +++ +L + + ++++ Sbjct: 132 HANIIHLFDIIKDPISKTPA----------LVFEYVDNVDFRILYPKLTDLEIRFYMFEL 181 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAP 232 L + + HS GI+HRD+KP N+++ + L+++D+GLA + V +R+++ P Sbjct: 182 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 241 Query: 233 EVILGMG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPE-FMKK 289 E+++ Y ++D+WS G ++ M+ + + F G DQ K+++ LGT E ++ K Sbjct: 242 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 301 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + T+ + +Y P F D + + DL+ +L D +R++ Sbjct: 302 YEITLPREFYDMDQYIRK------PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT 355 Query: 350 VDDALQHPYINVWYDP 365 +A+ HP W+ P Sbjct: 356 AKEAMGHP----WFAP 367 >2JAM-A nrPDB Length = 304 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 84/315 (26%), Positives = 138/315 (43%), Gaps = 63/315 (20%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK--KLSRPFQNQTHAKRAYRELVL 114 T + K + ++ +GSGA V + + A+K K S F++ + E+ + Sbjct: 4 TTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLE----NEIAV 59 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM------ELMDANLCQVIQMELDHERMSY 168 +K + H+NI++L +++ E YLVM EL D L + + E D S Sbjct: 60 LKKIKHENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKD---ASL 110 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVV 225 ++ Q+L +K+LH GI+HRDLKP N++ + + + I DFGL++ M T Sbjct: 111 VIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTA-CG 169 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y APEV+ Y + VD WS+G I IL G P Sbjct: 170 TPGYVAPEVLAQKPYSKAVDCWSIGVIT------YILLCGY-----------------PP 206 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 F ++ + + + K F F D + + A+D + +L DP Sbjct: 207 FYEETESKLFEKI----KEGYYEFESPFWDDI-----------SESAKDFICHLLEKDPN 251 Query: 346 KRISVDDALQHPYIN 360 +R + + AL HP+I+ Sbjct: 252 ERYTCEKALSHPWID 266 >4UZD-A nrPDB Length = 287 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 78/308 (25%), Positives = 134/308 (43%), Gaps = 57/308 (18%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 118 L+ ++ +P+G G G V A + +A+K L + + + RE+ + + Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL 65 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQM 173 H NI+ L F + VYL++E A L V + + D +R + + ++ Sbjct: 66 RHPNILRLYGYF------HDATRVYLILEY--APLGTVYRELQKLSKFDEQRTATYITEL 117 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 + + HS +IHRD+KP N+++ S LKI DFG + A +S T T Y PE Sbjct: 118 ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS-RRTTLCGTLDYLPPE 176 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 +I G + E VD+WS+G + E + K F Y + + ++ Sbjct: 177 MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRI------------------ 218 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 + VE TFP + ARDL+S++L +P++R + + Sbjct: 219 --SRVE-------FTFPDFVTEG---------------ARDLISRLLKHNPSQRPMLREV 254 Query: 354 LQHPYINV 361 L+HP+I Sbjct: 255 LEHPWITA 262 >3D2K-A nrPDB Length = 272 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 79/304 (25%), Positives = 132/304 (43%), Gaps = 65/304 (21%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA----KRAYRELVLMKCVNHKNI 123 +P+G G G V A + +A+K L F+ Q + RE+ + + H NI Sbjct: 18 RPLGKGKFGNVYLARERQSKFILALKVL---FKTQLEKAGVEHQLRREVEIQSHLRHPNI 74 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQMLCGIK 178 + L F + VYL++E A L V + D +R + + ++ + Sbjct: 75 LRLYGYF------HDATRVYLILEY--APLGTVYRELQKLSRFDEQRTATYITELANALS 126 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 + HS +IHRD+KP N+++ S+ LKI DFG + A +S T T Y PE+I G Sbjct: 127 YCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSS-RRTTLCGTLDYLPPEMIEGR 185 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNY 297 + E VD+WS+G + C EF+ + P Y Sbjct: 186 MHDEKVDLWSLGVL------------------------------CYEFLVGMPPFEAHTY 215 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 E + + + F FPD + ARDL+S++L + ++R+++ + L+HP Sbjct: 216 QETYRRISRVEFT--FPDFV-----------TEGARDLISRLLKHNASQRLTLAEVLEHP 262 Query: 358 YINV 361 +I Sbjct: 263 WIKA 266 >3DAK-A nrPDB Length = 290 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 66/211 (31%), Positives = 107/211 (50%), Gaps = 25/211 (11%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ + IGSGA +V AAY A VAIK+++ + QT +E+ M +H NI Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHHPNI 70 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM----------ELDHERMSYLLYQ 172 +S F + L +LVM+L+ ++ +I+ LD ++ +L + Sbjct: 71 VSYYTSFVVKDEL------WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT------PYVVT 226 +L G+++LH G IHRD+K NI++ D +++I DFG++ T +T +V T Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 184 Query: 227 RYYRAPEVILGM-GYKENVDIWSVGCIMGEM 256 + APEV+ + GY DIWS G E+ Sbjct: 185 PCWMAPEVMEQVRGYDFKADIWSFGITAIEL 215 >4D28-A nrPDB Length = 446 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 99/200 (49%), Gaps = 18/200 (9%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNH 120 +Y+ + IG G V A + NVAIK +++ +N+ + RE+ +MK V H Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRM-VDQIKREISIMKIVRH 68 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLC 175 NI+ L V + +Y+V+E + + +++ D R + Q++ Sbjct: 69 PNIVRLYEVLASK------SKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYF--QQLVD 120 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEV 234 + H HS G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV Sbjct: 121 AVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 235 ILGMGYKEN-VDIWSVGCIM 253 + G GY + DIWS G I+ Sbjct: 181 LSGQGYDGSAADIWSCGVIL 200 >4WNO-A nrPDB Length = 287 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 63/207 (30%), Positives = 101/207 (48%), Gaps = 20/207 (9%) Query: 70 IGSGAQGIVCAA-YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG GA +V + A D VA+K +++ ++ +E+ ++K + H+NI++L + Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG-KEIKILKELKHENIVALYD 84 Query: 129 VFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCGIKHLHSAGI 185 E VYLVME + +L + L + + L Q+ ++ LHS GI Sbjct: 85 F------QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGI 138 Query: 186 IHRDLKPSNIVVKS---------DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 IHRDLKP NI++ + +KI DFG AR ++ M + Y APEVI+ Sbjct: 139 IHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIM 198 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILF 263 Y D+WS+G I+ + + K F Sbjct: 199 SQHYDGKADLWSIGTIVYQCLTGKAPF 225 >4X3F-A nrPDB Length = 337 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 11/215 (5%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKC 117 T+ RY+ + I +G G V A D L R VA+K L F + +R E Sbjct: 9 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 68 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQ 172 +NH I S+ + Q E + YLVMEL++ L + ++ L H +L Q Sbjct: 69 LNHPGIASVHDYGESQMN-GEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHA--LDMLEQ 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYR 230 ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + +V T Y Sbjct: 126 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYI 185 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265 APE LG D++S+G + E V K F G Sbjct: 186 APEQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 220 >3F3Z-A nrPDB Length = 277 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 98/214 (45%), Gaps = 30/214 (14%) Query: 46 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 NQ+Y++E IG G+ G V A A KK+ + F Sbjct: 8 NQYYTLE---------------NTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD- 51 Query: 106 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDH 163 R +E+ +MK ++H NII L F E+ D+YLVMEL +V+ + Sbjct: 52 -RFKQEIEIMKSLDHPNIIRLYETF------EDNTDIYLVMELCTGGELFERVVHKRVFR 104 Query: 164 ER-MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT---LKILDFGLARTAGTSFM 219 E + ++ +L + + H + HRDLKP N + +D LK++DFGLA M Sbjct: 105 ESDAARIMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKM 164 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM 253 M V T YY +P+V+ G+ Y D WS G +M Sbjct: 165 MRTKVGTPYYVSPQVLEGL-YGPECDEWSAGVMM 197 >5D9K-A nrPDB Length = 330 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 70/252 (27%), Positives = 119/252 (47%), Gaps = 21/252 (8%) Query: 63 RYQNLKPIGSGAQGIV-----CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 +++ LK +G G+ G V + DA + A+K L + R E ++ Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDA--RQLYAMKVLKKATLKVRDRVRTKMERDILVE 88 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERMSYLLYQML 174 VNH I+ L F + L YL+++ + +L + E E + + L ++ Sbjct: 89 VNHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 233 + HLHS GII+RDLKP NI++ + +K+ DFGL++ + + T Y APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE-QLGTP---CPEFMKK 289 V+ G+ ++ D WS G +M EM+ + F G+D + +++ +LG P PE Sbjct: 203 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL 262 Query: 290 LQPTVRNYVENR 301 L+ + NR Sbjct: 263 LRMLFKRNPANR 274 >4OW8-A nrPDB Length = 283 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 11/215 (5%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKC 117 T+ RY+ + I +G G V A D L R VA+K L F + +R E Sbjct: 8 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 67 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQ 172 +NH I S+ + Q E + YLVMEL++ L + ++ L H +L Q Sbjct: 68 LNHPGIASVHDYGESQMN-GEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHA--LDMLEQ 124 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYR 230 ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + +V T Y Sbjct: 125 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYI 184 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265 APE LG D++S+G + E V K F G Sbjct: 185 APEQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 219 >1U5R-A nrPDB Length = 348 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 101/208 (48%), Gaps = 20/208 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKCVNH 120 K + +L+ IG G+ G V A D VAIKK+S Q+ + +E+ ++ + H Sbjct: 54 KLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH 113 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMEL---MDANLCQVIQMELDHERMSYLLYQMLCGI 177 N I + + T +LVME ++L +V + L ++ + + L G+ Sbjct: 114 PNTIQYRGCYLREHT------AWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGL 167 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAPEVI 235 +LHS +IHRD+K NI++ +K+ DFG A SF+ TP Y+ APEVI Sbjct: 168 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTP-----YWMAPEVI 222 Query: 236 LGMG---YKENVDIWSVGCIMGEMVRHK 260 L M Y VD+WS+G E+ K Sbjct: 223 LAMDEGQYDGKVDVWSLGITCIELAERK 250 >5F9E-A nrPDB Length = 353 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 67/247 (27%), Positives = 114/247 (46%), Gaps = 51/247 (20%) Query: 135 TLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLK 191 T + ++++ VME ++ +L IQ + D R ++ +++ G++ LHS GI++RDLK Sbjct: 88 TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLK 147 Query: 192 PSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEVILGMGYKENVDIWSVG 250 NI++ D +KI DFG+ + T + T Y APE++LG Y +VD WS G Sbjct: 148 LDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFG 207 Query: 251 CIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC-PEFMKKLQPTVRNYVENRPKYAGLTF 309 ++ EM+ + F G+D + ++ + ++ P P +++K Sbjct: 208 VLLYEMLIGQSPFHGQDEEELFHSI--RMDNPFYPRWLEK-------------------- 245 Query: 310 PKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV-DDALQHPYINV--WYDPA 366 +A+DLL K+ V +P KR+ V D QHP W + Sbjct: 246 ---------------------EAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELE 284 Query: 367 EVEAPPP 373 E PP Sbjct: 285 RKEIDPP 291 >2GCD-A nrPDB Length = 309 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 101/208 (48%), Gaps = 20/208 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKCVNH 120 K + +L+ IG G+ G V A D VAIKK+S Q+ + +E+ ++ + H Sbjct: 15 KLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH 74 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMEL---MDANLCQVIQMELDHERMSYLLYQMLCGI 177 N I + + T +LVME ++L +V + L ++ + + L G+ Sbjct: 75 PNTIQYRGCYLREHT------AWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGL 128 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRAPEVI 235 +LHS +IHRD+K NI++ +K+ DFG A SF+ TP Y+ APEVI Sbjct: 129 AYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTP-----YWMAPEVI 183 Query: 236 LGMG---YKENVDIWSVGCIMGEMVRHK 260 L M Y VD+WS+G E+ K Sbjct: 184 LAMDEGQYDGKVDVWSLGITCIELAERK 211 >2X7G-A nrPDB Length = 389 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 101/382 (26%), Positives = 153/382 (40%), Gaps = 82/382 (21%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 ++ V++GD RY ++ +G G V +D R VA+K + Q + + Sbjct: 20 YHPVKIGD---LFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTET 73 Query: 108 AYRELVLMKCV--------NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-- 157 A E+ L+KCV N ++ L++ F + + V +V E++ +L + I Sbjct: 74 ALDEIKLLKCVRESDPSDPNKDMVVQLIDDF--KISGMNGIHVCMVFEVLGHHLLKWIIK 131 Query: 158 --QMELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKSD-------------- 200 L + ++ Q+L G+ +LHS IIH D+KP NI++ D Sbjct: 132 SNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEW 191 Query: 201 ---------------------------------CTLKILDFGLARTAGTSFMMTPYVVTR 227 +KI D G A F T + TR Sbjct: 192 QKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHF--TEDIQTR 249 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF---PGRDYI---DQWNKVIEQLGT 281 YR+ EV++G GY DIWS C+ E+ LF G DY D +IE LG+ Sbjct: 250 QYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGS 309 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKL---KASQARDLLSK 338 P R + R + +T KL P SLF E A+Q D L Sbjct: 310 -IPRHFALSGKYSREFFNRRGELRHIT--KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP 366 Query: 339 MLVIDPAKRISVDDALQHPYIN 360 ML + P KR S + L+HP++N Sbjct: 367 MLEMVPEKRASAGECLRHPWLN 388 >4YNZ-A nrPDB Length = 342 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/315 (24%), Positives = 134/315 (42%), Gaps = 56/315 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K +G G G+V V + VAIK ++R +++ + RE+ ++K + H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLC---QVIQMELDHERMSYLLYQMLCGIKHL 180 + L +V+ +K L YLV+E + V + L + Q++ + Sbjct: 72 LKLHDVYENKKYL------YLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 HS I HRDLKP N+++ ++I DFG+A ++ + +Y PEVI G Y Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 241 K-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 D+WS G I+ ++ + F D N +++L V+ V Sbjct: 186 DGRKADVWSCGVILFALLVGALPF------DDDN-------------LRQLLEKVKRGVF 226 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + P + P D + LL M+ +D A+R++ L+H Sbjct: 227 HMPHF-------------IPPDCQ----------SLLRGMIEVDAARRLT----LEHIQK 259 Query: 360 NVWYDPAEVEAPPPQ 374 ++WY + E P Q Sbjct: 260 HIWYIGGKNEPEPEQ 274 >2BDW-A nrPDB Length = 362 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 89/329 (27%), Positives = 140/329 (42%), Gaps = 69/329 (20%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS- 96 N S DN E+G F+V++R + G+ AA + + KKLS Sbjct: 22 NASTKFSDNYDVKEELGKGAFSVVRRCVH------KTTGLEFAA------KIINTKKLSA 69 Query: 97 RPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LC 154 R FQ + RE + + + H NI+ L +++E YLV +L+ Sbjct: 70 RDFQ------KLEREARICRKLQHPNIVRL------HDSIQEESFHYLVFDLVTGGELFE 117 Query: 155 QVIQMELDHER-MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGL 210 ++ E E S+ + Q+L I + HS GI+HR+LKP N+++ S +K+ DFGL Sbjct: 118 DIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGL 177 Query: 211 ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 A S + T Y +PEV+ Y + VDIW+ G I+ IL G Sbjct: 178 AIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVIL------YILLVGY---- 227 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 P F + Q + + K +P D++ P Sbjct: 228 -------------PPFWDEDQHRLYAQI----KAGAYDYPSPEWDTVTP----------- 259 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYI 359 +A+ L+ ML ++P KRI+ D AL+ P+I Sbjct: 260 EAKSLIDSMLTVNPKKRITADQALKVPWI 288 >6B2Q-A nrPDB Length = 317 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 11/215 (5%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKC 117 T+ RY+ + I +G G V A D L R VA+K L F + +R E Sbjct: 29 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAM 88 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQ 172 +NH I S+ + Q E + YLVMEL++ L + ++ L H +L Q Sbjct: 89 LNHPGIASVHDYGESQMN-GEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHA--LDMLEQ 145 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYR 230 ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + +V T Y Sbjct: 146 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYI 205 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265 APE LG D++S+G + E V K F G Sbjct: 206 APEQALGHDASPASDVYSLGVVGYEAVSGKRPFAG 240 >4CQG-A nrPDB Length = 331 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 86/322 (26%), Positives = 140/322 (43%), Gaps = 58/322 (18%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 +LK Y+ + IG+G V A + VAIK + + + R E+ +K + Sbjct: 7 LLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-SDLPRVKTEIDALKSLR 65 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI--QMELDHERMSYLLYQMLCG 176 H++I L +V LE +++V+E L I Q L E + Q+L Sbjct: 66 HQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSA 119 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTS-FMMTPYVVTRYYRAPEV 234 + ++HS G HRDLKP N++ + LK++DFGL A+ G + + + Y APE+ Sbjct: 120 VAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPEL 179 Query: 235 ILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 I G Y D+WS+G ++ ++ + F + + + K++ Sbjct: 180 IQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIM----------------- 222 Query: 294 VRNYVENRPKYAGLTFPK-LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 R KY PK L P S+ LL +ML +DP KRIS+ + Sbjct: 223 -------RGKYE---VPKWLSPSSIL----------------LLQQMLQVDPKKRISMRN 256 Query: 353 ALQHPYINVWYD-PAEVEAPPP 373 L HP++ Y P E ++ P Sbjct: 257 LLNHPWVMQDYSCPVEWQSKTP 278 >6FDY-U nrPDB Length = 276 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 133/313 (42%), Gaps = 71/313 (22%) Query: 70 IGSGAQGIVCAAYDAVLDRNV-AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +GSG V AY R V AIK +++ N+ + E+ ++K + H +I+ L Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQL-- 76 Query: 129 VFTPQKTLEEFQ----DVYLVMEL-MDANLCQVIQME--LDHERMSYLLYQMLCGIKHLH 181 ++FQ ++YL+ME +L + I L + + Q+ ++ LH Sbjct: 77 --------KDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLH 128 Query: 182 SAGIIHRDLKPSNIVVKS--DCTLKILDFGLARTAGTSFMMTPY---VVTR---YYRAPE 233 I H DLKP NI++ S LK+ DFG A+ M+P+ V R Y APE Sbjct: 129 ERNISHLDLKPQNILLSSLEKPHLKLADFGFAQH------MSPWDEKHVLRGSPLYMAPE 182 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 ++ Y VD+WS+G I+ E + + F R + + K+ P L+P Sbjct: 183 MVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP-----LRP- 236 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 L + RDLL ++L DP++RIS D Sbjct: 237 ---------------------------------LLSRDCRDLLQRLLERDPSRRISFQDF 263 Query: 354 LQHPYINVWYDPA 366 HP++++ + P+ Sbjct: 264 FAHPWVDLEHMPS 276 >3GUB-A nrPDB Length = 295 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 127/311 (40%), Gaps = 63/311 (20%) Query: 64 YQNLKPIGSGAQGIV--CAAYDAVLDRNVAIKKLSRPFQNQTHAKRA--YRELVLMKCVN 119 Y + +GSG +V C L K R ++ R RE+ ++K + Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQMLCG 176 H N+I+L V+ E DV L+ EL+ E L E + L Q+L G Sbjct: 73 HPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNG 126 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCT----LKILDFGLARTAGTSFMMTPYVVTRYYRAP 232 + +LHS I H DLKP NI++ +KI+DFGLA T + AP Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAP 186 Query: 233 EVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 E++ LG+ D+WS+G I IL G P Sbjct: 187 EIVNYEPLGL----EADMWSIGVIT------YILLSG----------------ASPFLGD 220 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 Q T+ N + + + F D F S + A+D + ++LV DP KR+ Sbjct: 221 TKQETLAN-------VSAVNYE--FEDEYFSNTS-------ALAKDFIRRLLVKDPKKRM 264 Query: 349 SVDDALQHPYI 359 ++ D+LQHP+I Sbjct: 265 TIQDSLQHPWI 275 >6CMJ-A nrPDB Length = 321 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 75/314 (23%), Positives = 143/314 (45%), Gaps = 59/314 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYD---------AVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 L +Y IG G+ G+V AY+ VL + I++ Q + ++ Y+E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME-LDHERMSYL 169 + ++K ++H N++ L+ V +Y+V EL++ + +V ++ L ++ + Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPTLKPLSEDQARFY 148 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRY 228 ++ GI++LH IIHRD+KPSN++V D +KI DFG++ G+ +++ V T Sbjct: 149 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPA 208 Query: 229 YRAPEVI---LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 + APE + + + +D+W++G + V + CP Sbjct: 209 FMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQ----------------------CPF 246 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 +++ + ++ K L FP PD A +DL+++ML +P Sbjct: 247 MDERIM-----CLHSKIKSQALEFPDQ-PDI------------AEDLKDLITRMLDKNPE 288 Query: 346 KRISVDDALQHPYI 359 RI V + HP++ Sbjct: 289 SRIVVPEIKLHPWV 302 >3KK8-A nrPDB Length = 284 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 136/322 (42%), Gaps = 69/322 (21%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQT 103 DN E+G F+V++R + G+ AA + + KKLS R FQ Sbjct: 6 DNYDVKEELGKGAFSVVRRCVH------KTTGLEFAA------KIINTKKLSARDFQKLE 53 Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL 161 R R+L H NI+ L +++E YLV +L+ ++ E Sbjct: 54 REARICRKL------QHPNIVRL------HDSIQEESFHYLVFDLVTGGELFEDIVAREF 101 Query: 162 DHER-MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTS 217 E S+ + Q+L I + HS GI+HR+LKP N+++ S +K+ DFGLA S Sbjct: 102 YSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDS 161 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 + T Y +PEV+ Y + VDIW+ G I+ IL G Sbjct: 162 EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVIL------YILLVGY----------- 204 Query: 278 QLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 P F + Q + + K +P D++ P +A+ L+ Sbjct: 205 ------PPFWDEDQHRLYAQI----KAGAYDYPSPEWDTVTP-----------EAKSLID 243 Query: 338 KMLVIDPAKRISVDDALQHPYI 359 ML ++P KRI+ D AL+ P+I Sbjct: 244 SMLTVNPKKRITADQALKVPWI 265 >3UTO-A nrPDB Length = 573 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 86/368 (23%), Positives = 145/368 (39%), Gaps = 56/368 (15%) Query: 33 IAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAI 92 ++ +Y+ + Q+Y V VL Y + +G+GA G+V + N A Sbjct: 128 VSSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAA 187 Query: 93 KKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN 152 K + P ++ R +E+ M + H +++L + F E+ ++ ++ E M Sbjct: 188 KFVMTPHESDKETVR--KEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGG 239 Query: 153 -LCQVIQMELDHERMSY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIV--VKSDCTLK 204 L + + E H +MS + Q+ G+ H+H +H DLKP NI+ K LK Sbjct: 240 ELFEKVADE--HNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELK 297 Query: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 ++DFGL + T + APEV G D+WSVG + ++ F Sbjct: 298 LIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFG 357 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 G + E ++ ++ N DS F SE Sbjct: 358 GEN---------------DDETLRNVKSCDWN----------------MDDSAFSGISED 386 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 K D + K+L+ DP R+++ AL+HP++ P P Y K D + Sbjct: 387 GK-------DFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIK 439 Query: 385 HTIEEWKE 392 + W E Sbjct: 440 TKYDAWPE 447 >1KOA-A nrPDB Length = 491 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 87/354 (24%), Positives = 138/354 (38%), Gaps = 56/354 (15%) Query: 47 QFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK 106 Q+Y V VL Y + +G+GA G+V + N A K + P ++ Sbjct: 36 QYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETV 95 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDHER 165 R +E+ M + H +++L + F E+ ++ ++ E M L + + E H + Sbjct: 96 R--KEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADE--HNK 145 Query: 166 MSY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIV--VKSDCTLKILDFGLARTAGTSF 218 MS + Q+ G+ H+H +H DLKP NI+ K LK++DFGL Sbjct: 146 MSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQ 205 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 + T + APEV G D+WSVG + IL G Sbjct: 206 SVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLS------YILLSGLSPFG-------- 251 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 G E ++ ++ N DS F SE K D + K Sbjct: 252 -GENDDETLRNVKSCDWN----------------MDDSAFSGISEDGK-------DFIRK 287 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 +L+ DP R+++ AL+HP++ P P Y K D + + W E Sbjct: 288 LLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 341 >1KOB-A nrPDB Length = 387 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 70/303 (23%), Positives = 132/303 (43%), Gaps = 44/303 (14%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 +V Y L+ +GSGA G+V + R K ++ P+ + + E+ +M + Sbjct: 48 SVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK--NEISIMNQL 105 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H +I+L + F + + + EL D + +M + E ++Y+ Q G+K Sbjct: 106 HHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMS-EAEVINYMR-QACEGLK 163 Query: 179 HLHSAGIIHRDLKPSNIV--VKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 H+H I+H D+KP NI+ K ++KI+DFGLA ++ T + APE++ Sbjct: 164 HMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVD 223 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 D+W++G + ++ F G D ++ T++N Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLE----------------------TLQN 261 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 ++ F + P +A+D + +L +P KR++V DAL+H Sbjct: 262 VKRCDWEFDEDAFSSVSP----------------EAKDFIKNLLQKEPRKRLTVHDALEH 305 Query: 357 PYI 359 P++ Sbjct: 306 PWL 308 >3HKO-A nrPDB Length = 345 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 96/366 (26%), Positives = 150/366 (40%), Gaps = 99/366 (27%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR--- 110 G S + K+Y IG G+ G+V A + AIK +++ Q + K R Sbjct: 18 GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKT 77 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL---------------------- 148 E+ LMK ++H NI L V+ E+ Q + LVMEL Sbjct: 78 EVRLMKKLHHPNIARLYEVY------EDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCA 131 Query: 149 MDANLCQV-----------------IQMELD----HERMSYLLYQMLCGIKHLHSAGIIH 187 MD Q+ + LD + +S ++ Q+ + +LH+ GI H Sbjct: 132 MDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICH 191 Query: 188 RDLKPSNIVVKSDCT--LKILDFGLAR-----TAGTSFMMTPYVVTRYYRAPEVI--LGM 238 RD+KP N + ++ + +K++DFGL++ G + MT T Y+ APEV+ Sbjct: 192 RDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNE 251 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 Y D WS G ++ ++ + FPG + D ++V+ KKL Sbjct: 252 SYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN----------KKL------CF 295 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 EN P Y L+ ARDLLS +L + +R ALQHP+ Sbjct: 296 EN-PNYNVLS---------------------PLARDLLSNLLNRNVDERFDAMRALQHPW 333 Query: 359 INVWYD 364 I+ + D Sbjct: 334 ISQFSD 339 >2WTK-C nrPDB Length = 305 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 124/300 (41%), Gaps = 71/300 (23%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL----MDANLCQVIQMELDHER 165 +E+ L++ + HKN+I L++V EE Q +Y+VME M L V + + Sbjct: 55 KEIQLLRRLRHKNVIQLVDVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQ 110 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 Q++ G+++LHS GI+H+D+KP N+++ + TLKI G+A + P+ Sbjct: 111 AHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEA------LHPFAA 164 Query: 226 ---------TRYYRAPEVILGM----GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQW 272 + ++ PE+ G+ G+K VDIWS G + + F G D Sbjct: 165 DDTCRTSQGSPAFQPPEIANGLDTFSGFK--VDIWSAGVTLYNITTGLYPFEG----DNI 218 Query: 273 NKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQA 332 K+ E +G + YA P D Sbjct: 219 YKLFENIG--------------------KGSYA------------IPGDC------GPPL 240 Query: 333 RDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 DLL ML +PAKR S+ QH + + PAE P P D + R T+ + E Sbjct: 241 SDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLE 300 >6BDL-A nrPDB Length = 347 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 100/216 (46%), Gaps = 12/216 (5%) Query: 88 RNVAIKKLSRPFQNQTHAKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM 146 + A+K L + T + R E +M+ + I+ L F K L Y++M Sbjct: 61 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYL------YMLM 114 Query: 147 EL-MDANLCQVIQMELDHERMSYLLYQ--MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 E + L +++ E + Y ++ +LHS GII+RDLKP N+++ Sbjct: 115 EACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYA 174 Query: 204 KILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF 263 K++DFG A+ G + T Y APE+IL G+ + D WS+G +M E++ F Sbjct: 175 KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPF 234 Query: 264 PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 G D + +N ++ G EF KK+ N ++ Sbjct: 235 SGPDPMKTYNIILR--GIDMIEFPKKIAKNAANLIK 268 >6CQF-A nrPDB Length = 297 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 96/200 (48%), Gaps = 15/200 (7%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y L+ +G G G V A D V VA+K + + +E++++K H NI Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK--MEPDDDVSTLQKEILILKTCRHANI 75 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIKHL 180 ++ + Q +++ ME A Q I L ++SY+ ++L G+ +L Sbjct: 76 VAYHGSYL------WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYL 129 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPE---VIL 236 HS IHRD+K +NI++ +++ DFG++ G + ++ T Y+ APE V L Sbjct: 130 HSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVAL 189 Query: 237 GMGYKENVDIWSVGCIMGEM 256 GY E DIWS+G E+ Sbjct: 190 KGGYNELCDIWSLGITAIEL 209 >4TNB-A nrPDB Length = 590 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 12/209 (5%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 122 ++ + +G G G VCA + A K+L + + + A E +++ VN + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 +++L + + L LV+ +M+ ++ + + ER + ++LCG+ Sbjct: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 300 EDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGR 266 Y + D W +GC++ EM+ + F GR Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGR 388 >4REW-A nrPDB Length = 540 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/192 (30%), Positives = 89/192 (46%), Gaps = 17/192 (8%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V TP D+++VME + +C+ LD + L Q+L G+ + H Sbjct: 74 VISTPS-------DIFMVMEYVSGGELFDYICK--NGRLDEKESRRLFQQILSGVDYCHR 124 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK- 241 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 125 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 184 Query: 242 ENVDIWSVGCIM 253 VDIWS G I+ Sbjct: 185 PEVDIWSSGVIL 196 >5WAX-A nrPDB Length = 310 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 73/300 (24%), Positives = 125/300 (41%), Gaps = 45/300 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 RY+ ++ IGSG G+ + + VA+K + R + + RE++ + + H N Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYIER---GEKIDENVQREIINHRSLRHPN 68 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 II V L + EL + +C + D R + Q++ G+ + HS Sbjct: 69 IIRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHS 125 Query: 183 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 + HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 185 Query: 241 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 V D+WS G + M+ F D + K I+++ +Q ++ +YV Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRI--------LGVQYSIPDYVH 237 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P + +DL+S++ V +PA RI++ + HP+ Sbjct: 238 ISP----------------------------ECQDLISRIFVANPATRITIPEIRNHPWF 269 >5TQX-A nrPDB Length = 655 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 95/218 (43%), Gaps = 23/218 (10%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D F ++ + +G+G G VC LD +AIK + +R E+ + Sbjct: 1 DPEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR-ERWCHEIQI 59 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDV-YLVMELMDA-----------NLCQVIQMELD 162 MK +NH N++ +V P++ DV L ME N C L Sbjct: 60 MKKLNHANVVKACDV--PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCG-----LK 112 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV---VKSDCTLKILDFGLARTAGTSFM 219 ++ LL + GI++LH IIHRDLKP NIV V KI+D G A+ + Sbjct: 113 ESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGEL 172 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 T +V T Y APE+ Y VD WS G ++ E + Sbjct: 173 CTEFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECI 210 >4CZT-A nrPDB Length = 464 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 96/429 (22%), Positives = 175/429 (40%), Gaps = 95/429 (22%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMK 116 T + +Y+ + +G G V A + NVAIK + + +N+ A + RE+ MK Sbjct: 8 TRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMK 66 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLY 171 + H N+I + V + +Y V+E + + +++ D R + Sbjct: 67 LIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--Q 118 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA------RTAGTSFMMTPYVV 225 Q++ + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ R G ++ Sbjct: 119 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDG---LLHTTCG 175 Query: 226 TRYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 T Y APEVI GY D+WS G I+ ++ + F + + K+ + Sbjct: 176 TPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFK------- 228 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 A T P F ++ A+ L+ ++L +P Sbjct: 229 --------------------AEFTCPPWF---------------SASAKKLIKRILDPNP 253 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 A RI+ + +++ + Y +AP + D LD+ + ++ E V EE Sbjct: 254 ATRITFAEVIENEWFKKGY-----KAPKFENADVSLDDVDAIFDDSGESKNLVVERREEG 308 Query: 405 TKNGVVKGQPSPSGAAVNSSESLPPSSSVNDIS------------SMSTDQTLASDTDSS 452 K V +N+ E + S +N S + T ++ A++ + Sbjct: 309 LKTPVT----------MNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTK 358 Query: 453 LEASAGPLG 461 +EA+A P+G Sbjct: 359 IEAAAAPMG 367 >2A27-A nrPDB Length = 321 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 81/308 (26%), Positives = 130/308 (42%), Gaps = 67/308 (21%) Query: 70 IGSGAQGIV--CAAYDAVLDRNVAI--KKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +GSG IV C L+ K+ SR + + RE+ +++ V H N+I+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHL 180 L +V+ E DV L++EL+ L Q + L E + + Q+L G+ +L Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQILDGVNYL 131 Query: 181 HSAGIIHRDLKPSNIVVKSDCT----LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI- 235 H+ I H DLKP NI++ +K++DFGLA T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 236 ---LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 LG+ D+WS+G I IL G P Q Sbjct: 192 YEPLGL----EADMWSIGVIT------YILLSG----------------ASPFLGDTKQE 225 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 T+ N +++ F + F SE A+D + K+LV + KR+++ + Sbjct: 226 TLAN-------ITAVSYD--FDEEFFSQTSE-------LAKDFIRKLLVKETRKRLTIQE 269 Query: 353 ALQHPYIN 360 AL+HP+I Sbjct: 270 ALRHPWIT 277 >4CFH-A nrPDB Length = 493 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/192 (30%), Positives = 89/192 (46%), Gaps = 17/192 (8%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V TP D+++VME + +C+ LD + L Q+L G+ + H Sbjct: 101 VISTPS-------DIFMVMEYVSGGELFDYICK--NGRLDEKESRRLFQQILSGVDYCHR 151 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK- 241 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 211 Query: 242 ENVDIWSVGCIM 253 VDIWS G I+ Sbjct: 212 PEVDIWSSGVIL 223 >2XNP-A nrPDB Length = 279 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 101/208 (48%), Gaps = 21/208 (10%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAI-KKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 Y+ L IG+G+ G C D + + K+L + + E+ L++ + H N Sbjct: 8 YEVLYTIGTGSYG-RCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVI------QMELDHERMSYLLYQMLC 175 I+ + + +Y+VME + +L VI + LD E + ++ Q+ Sbjct: 67 IVRYYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122 Query: 176 GIKHLHSAG-----IIHRDLKPSNIVVKSDCTLKILDFGLARTAG--TSFMMTPYVVTRY 228 +K H ++HRDLKP+N+ + +K+ DFGLAR TSF T +V T Y Sbjct: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKT-FVGTPY 181 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEM 256 Y +PE + M Y E DIWS+GC++ E+ Sbjct: 182 YMSPEQMNRMSYNEKSDIWSLGCLLYEL 209 >1ZWS-A nrPDB Length = 288 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 81/308 (26%), Positives = 128/308 (41%), Gaps = 67/308 (21%) Query: 70 IGSGAQGIV--CAAYDAVLDRNVAI--KKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +GSG IV C L+ K+ SR + + RE+ +++ V H N+I+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHL 180 L +V+ E DV L++EL+ L Q + L E + + Q+L G+ +L Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQILDGVNYL 131 Query: 181 HSAGIIHRDLKPSNIVVKSDCT----LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI- 235 H+ I H DLKP NI++ +K++DFGLA T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 236 ---LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 LG+ D+WS+G I IL G P Q Sbjct: 192 YEPLGL----EADMWSIGVIT------YILLSG----------------ASPFLGDTKQE 225 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 T+ N + F + F SE A+D + K+LV + KR+++ + Sbjct: 226 TLANIT---------SVSYDFDEEFFSHTSE-------LAKDFIRKLLVKETRKRLTIQE 269 Query: 353 ALQHPYIN 360 AL+HP+I Sbjct: 270 ALRHPWIT 277 >3ORP-A nrPDB Length = 311 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 104/214 (48%), Gaps = 16/214 (7%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKCVNHK 121 RY+ + +G G V A D R+VA+K L ++ + R RE +NH Sbjct: 13 RYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHP 72 Query: 122 NIISLLNVF---TPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLC 175 I+++ + TP L Y+VME +D L ++ E + +R ++ Sbjct: 73 AIVAVYDTGEAETPAGPLP-----YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTPYVV-TRYYRA 231 + H GIIHRD+KP+NI++ + +K++DFG+AR +G S T V+ T Y + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG 265 PE G D++S+GC++ E++ + F G Sbjct: 188 PEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTG 221 >6CKI-A nrPDB Length = 316 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 87/312 (27%), Positives = 137/312 (43%), Gaps = 53/312 (16%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISLLN 128 +G GA V + + + A+K + + Q R +RE+ +L +C H+N++ L+ Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEK--QPGHIRSRVFREVEMLYQCQGHRNVLELIE 78 Query: 129 VFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHE-RMSYLLYQMLCGIKHLHSAGI 185 F + YLV E M L + + +E S ++ + + LH+ GI Sbjct: 79 FFEEEDRF------YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGI 132 Query: 186 IHRDLKPSNIVVKSD---CTLKILDFGLAR----TAGTSFMMTPYVVT----RYYRAPEV 234 HRDLKP NI+ + +KI DFGL S + TP ++T Y APEV Sbjct: 133 AHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEV 192 Query: 235 ILGMG-----YKENVDIWSVGCIMGEMVRHKILFPGRDYID-QWNKVIEQLGTPCPEFMK 288 + Y + D+WS+G I+ ++ F GR D W++ G CP Sbjct: 193 VEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDR-----GEACPACQN 247 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 L +++ KY FPD D H + A+DL+SK+LV D +R+ Sbjct: 248 MLFESIQE-----GKYE-------FPDK----DWAH---ISCAAKDLISKLLVRDAKQRL 288 Query: 349 SVDDALQHPYIN 360 S LQHP++ Sbjct: 289 SAAQVLQHPWVQ 300 >2YAB-A nrPDB Length = 361 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 82/308 (26%), Positives = 130/308 (42%), Gaps = 67/308 (21%) Query: 70 IGSGAQGIV--CAAYDAVLDRNVAI--KKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +GSG IV C L+ K+ SR + + RE+ +++ V H NII+ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHL 180 L +V+ E DV L++EL+ L Q + L E + + Q+L G+ +L Sbjct: 80 LHDVY------ENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQILDGVNYL 131 Query: 181 HSAGIIHRDLKPSNIVVKSDCT----LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI- 235 H+ I H DLKP NI++ +K++DFGLA T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVN 191 Query: 236 ---LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 LG+ D+WS+G I IL G P Q Sbjct: 192 YEPLGL----EADMWSIGVIT------YILLSG----------------ASPFLGDTKQE 225 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 T+ N +++ F + F SE A+D + K+LV + KR+++ + Sbjct: 226 TLAN-------ITAVSYD--FDEEFFSQTSE-------LAKDFIRKLLVKETRKRLTIQE 269 Query: 353 ALQHPYIN 360 AL+HP+I Sbjct: 270 ALRHPWIT 277 >4C0T-A nrPDB Length = 974 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 77/332 (23%), Positives = 133/332 (40%), Gaps = 85/332 (25%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI---- 123 K +G G+ V A D + + A+K L + R ++ K V + NI Sbjct: 272 KELGEGSYSTVILATDKITGKQYAVKVLDK------------RHIIKEKKVKYVNIEKHA 319 Query: 124 ----ISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM--ELDHERMSYLLYQMLCG 176 + L V + T ++ +Y V++ + L +I+ L+ E + Q+L Sbjct: 320 LNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDA 379 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG----------TSFMMTPYVVT 226 IK++H G+IHRDLKP NI++ ++I DFG AR +V T Sbjct: 380 IKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGT 439 Query: 227 RYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 Y +PE++ + D+W+ GCI+ +M+ K F + + K+ Sbjct: 440 AEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKIT---------- 489 Query: 287 MKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 KLQ F FP + RDL+ K+LV+ P++ Sbjct: 490 --KLQ---------------FAFSAGFPTII---------------RDLIKKILVLQPSR 517 Query: 347 RISVDDALQHPYI---------NVWY-DPAEV 368 R ++ + +H + ++W DP E+ Sbjct: 518 RATIPEIQKHYFFQSVDFKDFDSIWLSDPPEI 549 >3TAC-A nrPDB Length = 361 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 70/262 (26%), Positives = 115/262 (43%), Gaps = 56/262 (21%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELD------ 162 RE + + H +I+ LL ++ L Y+V E MD A+LC I D Sbjct: 77 REASICHMLKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYS 130 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFM 219 S+ + Q+L +++ H IIHRD+KP +++ S +K+ FG+A G S + Sbjct: 131 EAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGL 190 Query: 220 MT-PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 + V T ++ APEV+ Y + VD+W G I+ IL G Sbjct: 191 VAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVIL------FILLSG------------- 231 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 C F + ++ + K + P H + A+DL+ + Sbjct: 232 ----CLPFYGTKERLFEGIIKGKYK-------------MNPRQWSH---ISESAKDLVRR 271 Query: 339 MLVIDPAKRISVDDALQHPYIN 360 ML++DPA+RI+V +AL HP++ Sbjct: 272 MLMLDPAERITVYEALNHPWLK 293 >3ORZ-A nrPDB Length = 316 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 77/319 (24%), Positives = 133/319 (41%), Gaps = 62/319 (19%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 K +G G+ V A + R AIK L R + RE +M ++H + L Sbjct: 43 KILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMSYLLYQMLCGIKHLHSAG 184 F + L + + + L + I+ D + +++ +++LH G Sbjct: 103 YFCFQDDEKL-----YFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKG 157 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTPYVVTRYYRAPEVILGMGYK 241 IIHRDLKP NI++ D ++I DFG A+ +V T Y +PE++ Sbjct: 158 IIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSAC 217 Query: 242 ENVDIWSVGCIMGEMVRHKILF-PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 ++ D+W++GCI+ ++V F G +Y+ + K+I KL+ Sbjct: 218 KSSDLWALGCIIYQLVAGLPPFRAGNEYL-IFQKII------------KLEYD------- 257 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA------L 354 FP+ FP +ARDL+ K+LV+D KR+ ++ Sbjct: 258 ------------FPEKFFP-----------KARDLVEKLLVLDATKRLGCEEMEGYGPLK 294 Query: 355 QHPYI-NVWYDPAEVEAPP 372 HP+ +V ++ + PP Sbjct: 295 AHPFFESVTWENLHQQTPP 313 >5YKS-A nrPDB Length = 377 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 57/196 (29%), Positives = 91/196 (46%), Gaps = 12/196 (6%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 K +G G +V A VA+K + + + ++E+ MK V H NI+ L Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLY 100 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQME--LDHERMSYLLYQMLCGIKHLHSA 183 V Q L YL++EL D +++ E L+ + Q++ I + H Sbjct: 101 EVIDTQTKL------YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 184 GIIHRDLKPSNIV-VKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 ++HRDLKP N+V + +K+ DFG + +T + Y APE++LG Y Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 243 -NVDIWSVGCIMGEMV 257 VDIWS+G I+ +V Sbjct: 215 PAVDIWSLGVILFMLV 230 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 33/58 (56%), Gaps = 2/58 (3%) Query: 329 ASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREH 385 + + +DL+++ML DP +R S+++ HP++ DP+ + P + K L E EH Sbjct: 260 SKECKDLITRMLQRDPKRRASLEEIENHPWLQ-GVDPSPATKYNIPLVSYKNLSEEEH 316 >4RED-A nrPDB Length = 351 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/192 (30%), Positives = 89/192 (46%), Gaps = 17/192 (8%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V TP D+++VME + +C+ LD + L Q+L G+ + H Sbjct: 82 VISTPS-------DIFMVMEYVSGGELFDYICK--NGRLDEKESRRLFQQILSGVDYCHR 132 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 Query: 243 -NVDIWSVGCIM 253 VDIWS G I+ Sbjct: 193 PEVDIWSSGVIL 204 >3UDB-A nrPDB Length = 317 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 122/299 (40%), Gaps = 45/299 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 RY+ +K IG+G G+ D + VA+K + R + + KR E++ + + H N Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 I+ V L + EL + +C + D R + Q++ G+ + H+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYAHA 133 Query: 183 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 + HRDLK N ++ LKI DFG ++ + V T Y APEV+L Y Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 241 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 V D+WS G + M+ F + + K I ++ +Q + +YV Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 P + R L+S++ V DPAKRIS+ + H + Sbjct: 246 ISP----------------------------ECRHLISRIFVADPAKRISIPEIRNHEW 276 >4WB7-A nrPDB Length = 405 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 105/210 (50%), Gaps = 30/210 (14%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L +++ +K +G+G+ G V + A+K L + +++V +K + H Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDK------------QKVVKLKQIEH 142 Query: 121 ----KNIISLLNVFTPQKTLEEFQD---VYLVMEL-----MDANLCQVIQMELDHERMSY 168 K I+ +N K F+D +Y+VME M ++L ++ + H R + Sbjct: 143 TLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--F 200 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTR 227 Q++ ++LHS +I+RDLKP N+++ +++ DFG A R G ++ + T Sbjct: 201 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TP 257 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 Y APE+IL GY + VD W++G ++ EM Sbjct: 258 EYLAPEIILSKGYNKAVDWWALGVLIYEMA 287 >3QD2-B nrPDB Length = 332 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 69/267 (25%), Positives = 113/267 (42%), Gaps = 71/267 (26%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L ++ ++ +G G G+V A + V D N AIK++ P + ++ RE+ + + H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEH 63 Query: 121 KNIISLLNVFT---PQKTLEEFQDVYLVMEL----------MDANLCQV----------- 156 I+ N + P+K EE +++L E MDA ++ Sbjct: 64 PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNT 123 Query: 157 --------------IQMEL-------------------DHERMSYLLYQMLCGIKHLHSA 183 IQM+L +H ++ Q+ ++ LHS Sbjct: 124 VGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLA----RTAGTSFMMTPY---------VVTRYYR 230 G++HRDLKPSNI D +K+ DFGL + ++TP V T+ Y Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMV 257 +PE I G Y VDI+S+G I+ E++ Sbjct: 244 SPEQIHGNNYSHKVDIFSLGLILFELL 270 >5LOH-A nrPDB Length = 341 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 118/251 (47%), Gaps = 22/251 (8%) Query: 61 LKRYQNLKPIGSGAQG-IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE-LVLMKCV 118 ++ + +KPI GA G + L +KK +N TH +A R+ L L K Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS- 93 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVME-LMDANLCQVIQME--LDHERMSYLLYQMLC 175 I+ L +L+ +VYLVME L+ ++ ++ + D E + ++ Sbjct: 94 --PFIVHLY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVAL 145 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-TAGTSFMMTPYVVTRY------ 228 + +LH GIIHRDLKP N+++ ++ +K+ DFGL++ T M + TR Sbjct: 146 ALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPD 205 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y APE++LG + VD W++G + E + F + ++++ P PE + Sbjct: 206 YLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKR-DIPWPEGEE 264 Query: 289 KLQPTVRNYVE 299 KL ++ VE Sbjct: 265 KLSDNAQSAVE 275 >5DYK-A nrPDB Length = 853 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 13/208 (6%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF---QNQTHAKRAYRELVLMKCVNHKNII 124 + IG G G V + A+K +S+ NQ + + RE+ +H II Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEN--DHPFII 602 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAG 184 L+ F K ++ EL DA + + + L + + L ++ I++LH Sbjct: 603 RLVRTFKDSKYFYFLTELVTGGELYDA--IRKLGL-LSKSQAQFYLGSIILAIEYLHERN 659 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 I++RDLKP NI++ +K++DFG A+ G ++ + V T +Y APEVILG GY Sbjct: 660 IVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTL---VGTPHYMAPEVILGKGYGCT 716 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 VDIW++G + E + + F G D DQ Sbjct: 717 VDIWALGICLYEFICGPLPF-GNDEEDQ 743 >4CFF-A nrPDB Length = 571 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 91/342 (26%), Positives = 135/342 (39%), Gaps = 63/342 (18%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V TP D ++VME + +C+ ++E R L Q+L + + H Sbjct: 101 VISTPT-------DFFMVMEYVSGGELFDYICKHGRVEEMEARR--LFQQILSAVDYCHR 151 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK- 241 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 152 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 211 Query: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 VDIWS G I+ ++ + F P KK +R V Sbjct: 212 PEVDIWSCGVILYALLCGTLPFDDEH---------------VPTLFKK----IRGGVFYI 252 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 P+Y N+ A+ LL ML +DP KR ++ D +H + Sbjct: 253 PEYL-------------------NRSVAT----LLMHMLQVDPLKRATIKDIREHEWFK- 288 Query: 362 WYDPAEVEAPPPQIYDKQL--DEREHTIEEWKELIYKEVMNS 401 D P YD + DE + E E EVMNS Sbjct: 289 -QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 329 >5EZV-A nrPDB Length = 560 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 91/342 (26%), Positives = 135/342 (39%), Gaps = 63/342 (18%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V TP D ++VME + +C+ ++E R L Q+L + + H Sbjct: 96 VISTPT-------DFFMVMEYVSGGELFDYICKHGRVEEMEARR--LFQQILSAVDYCHR 146 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK- 241 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 147 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 206 Query: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 VDIWS G I+ ++ + F P KK +R V Sbjct: 207 PEVDIWSCGVILYALLCGTLPFDDEH---------------VPTLFKK----IRGGVFYI 247 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 P+Y N+ A+ LL ML +DP KR ++ D +H + Sbjct: 248 PEYL-------------------NRSVAT----LLMHMLQVDPLKRATIKDIREHEWFK- 283 Query: 362 WYDPAEVEAPPPQIYDKQL--DEREHTIEEWKELIYKEVMNS 401 D P YD + DE + E E EVMNS Sbjct: 284 -QDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 324 >3ZUT-A nrPDB Length = 362 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 74/300 (24%), Positives = 122/300 (40%), Gaps = 45/300 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 RY+ +K IGSG G+ D + VA+K + R + + KR E++ + + H N Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKR---EIINHRSLRHPN 76 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 I+ V L + EL + +C + D R + Q++ G+ + H+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFE-RICNAGRFSEDEAR--FFFQQLISGVSYCHA 133 Query: 183 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 + HRDLK N ++ LKI FG ++++ V T Y APEV+L Y Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 241 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 V D+WS G + M+ F + + K I ++ +Q + +YV Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIPDYVH 245 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P + R L+S++ V DPAKRIS+ + H + Sbjct: 246 ISP----------------------------ECRHLISRIFVADPAKRISIPEIRNHEWF 277 >5YV8-A nrPDB Length = 298 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/330 (23%), Positives = 144/330 (43%), Gaps = 74/330 (22%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP---------------------- 98 L +Y IG G+ G+V AY+ + A+K LS+ Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 99 --FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQ 155 Q + ++ Y+E+ ++K ++H N++ L+ V +Y+V EL++ + + Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVME 127 Query: 156 VIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART- 213 V ++ L ++ + ++ GI++LH IIHRD+KPSN++V D +KI DFG++ Sbjct: 128 VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEF 187 Query: 214 AGTSFMMTPYVVTRYYRAPEVI---LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 G+ +++ V T + APE + + + +D+W++G + V + Sbjct: 188 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQ---------- 237 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 CP +++ + ++ K L FP PD A Sbjct: 238 ------------CPFMDERIM-----CLHSKIKSQALEFPDQ-PDI------------AE 267 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYIN 360 +DL+++ML +P RI V + HP++ Sbjct: 268 DLKDLITRMLDKNPESRIVVPEIKLHPWVT 297 >5X3F-B nrPDB Length = 393 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 102/206 (49%), Gaps = 22/206 (10%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L ++ +K +G+G+ G V + A+K L + ++ + + +N Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDK--------QKVVKLKQIEHTLNE 134 Query: 121 KNIISLLNVFTPQKTLEEFQD---VYLVMEL-----MDANLCQVIQMELDHERMSYLLYQ 172 K I+ +N K F+D +Y+VME M ++L ++ + H R + Q Sbjct: 135 KRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHAR--FYAAQ 192 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRA 231 ++ ++LHS +I+RDLKP N+++ +++ DFG A R G ++ + T Y A Sbjct: 193 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCG---TPEYLA 249 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMV 257 PE+IL GY + VD W++G ++ EM Sbjct: 250 PEIILSKGYNKAVDWWALGVLIYEMA 275 >2X4F-A nrPDB Length = 373 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 131/298 (43%), Gaps = 54/298 (18%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + +A K + +R +++ K E+ +M ++H N+I L + Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN---EISVMNQLDHANLIQLYD 153 Query: 129 VFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLY--QMLCGIKHLHSAG 184 F E D+ LVME +D ++I + + +L+ Q+ GI+H+H Sbjct: 154 AF------ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMY 207 Query: 185 IIHRDLKPSNIV-VKSDCT-LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 I+H DLKP NI+ V D +KI+DFGLAR + T + APEV+ Sbjct: 208 ILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSF 267 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 D+WSVG I ++ F G + + N ++ R +E Sbjct: 268 PTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL----------------ACRWDLE--- 308 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 D F SE +A++ +SK+L+ + + RIS +AL+HP+++ Sbjct: 309 ------------DEEFQDISE-------EAKEFISKLLIKEKSWRISASEALKHPWLS 347 >1PHK-A nrPDB Length = 298 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 106/254 (41%), Gaps = 47/254 (18%) Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQ 172 +L K H NII L + + D+ EL D +V E + ++ L + Sbjct: 76 ILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLE 135 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAP 232 ++C LH I+HRDLKP NI++ D +K+ DFG + + T Y AP Sbjct: 136 VICA---LHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAP 192 Query: 233 EVI-LGM-----GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 E+I M GY + VD+WS G IM ++ G+P P + Sbjct: 193 EIIECSMNDNHPGYGKEVDMWSTGVIMYTLLA---------------------GSP-PFW 230 Query: 287 MKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 +K +R + ++ P ++ + +DL+S+ LV+ P K Sbjct: 231 HRKQMLMLRMIMSGNYQFGS------------PEWDDY----SDTVKDLVSRFLVVQPQK 274 Query: 347 RISVDDALQHPYIN 360 R + ++AL HP+ Sbjct: 275 RYTAEEALAHPFFQ 288 >4B8L-A nrPDB Length = 286 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 72/304 (23%), Positives = 120/304 (39%), Gaps = 65/304 (21%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK----RAYRELVLMKCVNHKNI 123 +P+G G G V Y A +N I L F++Q + + RE+ + + H NI Sbjct: 21 RPLGKGKFGNV---YLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNI 77 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM--ELDHERMSYLLYQMLCGIKHL 180 + + N F +K +YL++E L + +Q D +R + + ++ + + Sbjct: 78 LRMYNYFHDRKR------IYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H +IHRD+KP N+++ LKI DFG + A S T Y PE+I G + Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWSVHA-PSLRRRTMCGTLDYLPPEMIEGKTH 190 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP---TVRNY 297 E VD+W G + C EF+ + P Sbjct: 191 DEKVDLWCAGVL------------------------------CYEFLVGMPPFDSPSHTE 220 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 R L FP D ++DL+SK+L P +R+ + ++HP Sbjct: 221 THRRIVNVDLKFPPFLSDG---------------SKDLISKLLRYHPPQRLPLKGVMEHP 265 Query: 358 YINV 361 ++ Sbjct: 266 WVKA 269 >4FR4-A nrPDB Length = 384 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 101/204 (49%), Gaps = 13/204 (6%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKN 122 ++ L+ IG G+ G VC + A+K +++ + + ++EL +M+ + H Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 76 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQ--MELDHERMSYLLYQMLCGIKH 179 +++L F + +D+++V++L+ +L +Q + E + + +++ + + Sbjct: 77 LVNLWYSFQDE------EDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDY 130 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI---L 236 L + IIHRD+KP NI++ + I DF +A +T T+ Y APE+ Sbjct: 131 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRK 190 Query: 237 GMGYKENVDIWSVGCIMGEMVRHK 260 G GY VD WS+G E++R + Sbjct: 191 GAGYSFAVDWWSLGVTAYELLRGR 214 >3NYO-A nrPDB Length = 576 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 75/305 (24%), Positives = 130/305 (42%), Gaps = 55/305 (18%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR-AYRELVLMKCVNHKN 122 ++ + +G G G VCA + A KKL + + + A E +++ VN + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 ++SL + + L LV+ LM+ ++ + Q R + ++ CG+ Sbjct: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 + LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y + D W++GC++ EM+ G+ Q K I+ + V Sbjct: 360 ERYTFSPDWWALGCLLYEMI------AGQSPFQQRKKKIK-------------REEVERL 400 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SVDD 352 V+ P+ E+++ + QAR L S++L DPA+R+ S + Sbjct: 401 VKEVPE-------------------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 Query: 353 ALQHP 357 +HP Sbjct: 442 VKEHP 446 >3FXW-A nrPDB Length = 336 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 68/270 (25%), Positives = 107/270 (39%), Gaps = 76/270 (28%) Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLN-----VFTPQKTLEEFQDVYLVMELMDANL 153 ++N H KR L++M+C+ + S + FT ++ E +D+ Sbjct: 91 YENMHHGKRCL--LIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIG---------- 138 Query: 154 CQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGL 210 I+ LHS I HRD+KP N++ S D LK+ DFG Sbjct: 139 ---------------------TAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGF 177 Query: 211 ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 A+ + + TP T YY APEV+ Y ++ D+WS+G IM IL G Sbjct: 178 AKETTQNALQTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIM------YILLCG----- 225 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 P F + ++ R + FP P SE + Sbjct: 226 ------------FPPFYSNTGQAISPGMKRRIRLGQYGFPN-------PEWSE----VSE 262 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYIN 360 A+ L+ +L DP +R+++ + HP+IN Sbjct: 263 DAKQLIRLLLKTDPTERLTITQFMNHPWIN 292 >3VN9-A nrPDB Length = 340 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/244 (27%), Positives = 114/244 (46%), Gaps = 30/244 (12%) Query: 51 VEVGDSTFTVLKRYQNLKPI---GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 + +G+ F V + +L+PI G GA G+V + +A+K++ R N KR Sbjct: 39 ISIGNQNFEV--KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 Query: 108 AYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER- 165 +L + M+ V+ ++ + DV++ MELMD +L + + +D + Sbjct: 96 LLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQT 149 Query: 166 -----MSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 219 + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ S Sbjct: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 Query: 220 MTPYVVTRYYRAPEVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 T + Y APE I GY DIWS+G M E+ + FP D W Sbjct: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI--LRFP----YDSWGTP 263 Query: 276 IEQL 279 +QL Sbjct: 264 FQQL 267 >5X5O-A nrPDB Length = 310 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 117/252 (46%), Gaps = 27/252 (10%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 Q + G G+ G V A D+ VA+KKL + +E ++ ++H+NII Sbjct: 18 QFFENCGGGSFGSVYRAKWISQDKEVAVKKL----------LKIEKEAEILSVLSHRNII 67 Query: 125 SLLNVFTP---QKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 181 V + E+ + + + +++N + +M++DH + + G+ +LH Sbjct: 68 QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSE--EMDMDH--IMTWATDVAKGMHYLH 123 Query: 182 SAG---IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 +IHRDLK N+V+ +D LKI DFG +R + M+ V T + APEVI + Sbjct: 124 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTFPWMAPEVIQSL 182 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-----LGTPCPE-FMKKLQP 292 E D +S G ++ EM+ ++ F G + + V+E+ + + CP F + L Sbjct: 183 PVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQ 242 Query: 293 TVRNYVENRPKY 304 + RP + Sbjct: 243 CWEADAKKRPSF 254 >4D2V-A nrPDB Length = 356 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 90/327 (27%), Positives = 138/327 (42%), Gaps = 62/327 (18%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 +LK Y+ + IG+G V A + VAIK + + + R E+ +K + Sbjct: 27 LLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNLR 85 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI--QMELDHERMSYLLYQMLCG 176 H++I L +V LE +++V+E L I Q L E + Q++ Sbjct: 86 HQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSA 139 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTS-FMMTPYVVTRYYRAPEV 234 + ++HS G HRDLKP N++ LK++DFGL A+ G + + Y APE+ Sbjct: 140 VAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPEL 199 Query: 235 ILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 I G Y D+WS+G ++ +L G F+ T Sbjct: 200 IQGKSYLGSEADVWSMGILL------YVLMCG--------------------FLPFDDDT 233 Query: 294 VRNYVEN--RPKYAGLTFPK-LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 V R KY PK L P S+ LL +ML +DP KRIS+ Sbjct: 234 AAALVAKIMRGKY---DVPKWLSPSSIL----------------LLQQMLQVDPKKRISM 274 Query: 351 DDALQHPYINVWYD-PAEVEAPPPQIY 376 + L HP+I Y+ P E ++ P I+ Sbjct: 275 KNLLNHPWIMQDYNYPVEWQSKNPFIH 301 >5N23-A nrPDB Length = 352 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 103/208 (49%), Gaps = 25/208 (12%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L +++ ++ +G+G+ G V + A+K L + ++ + + +N Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDK--------QKVVKLKQIEHTLNE 92 Query: 121 KNIISLLNVFTPQKTLEEFQD---VYLVMEL-----MDANLCQVIQMELDHERMSYLLYQ 172 K I +N K F+D +Y+V+E M ++L ++ + H R + Q Sbjct: 93 KRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHAR--FYAAQ 150 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVV--TRYY 229 ++ ++LHS +I+RDLKP N+++ +K+ DFG A R G TP+ + T Y Sbjct: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGR----TPWTLCGTPEY 206 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMV 257 APE+IL GY + VD W++G ++ EM Sbjct: 207 LAPEIILSKGYNKAVDWWALGVLIYEMA 234 >4L42-A nrPDB Length = 346 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 105/226 (46%), Gaps = 21/226 (9%) Query: 64 YQNLKPIGSGAQGIVC---AAYDAVLDRNVAIKKLSRPF--QNQTHAKRAYRELVLMKCV 118 ++ L+ +G G G V A + A+K L + +N E +++ V Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERM------SYLLYQ 172 H I+ L+ F L YL++E + + M+L+ E + + L + Sbjct: 80 KHPFIVDLIYAFQTGGKL------YLILEYLSGG---ELFMQLEREGIFMEDTACFYLAE 130 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRA 231 + + HLH GII+RDLKP NI++ +K+ DFGL + + +T + T Y A Sbjct: 131 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 190 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 PE+++ G+ VD WS+G +M +M+ F G + +K+++ Sbjct: 191 PEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 236 >2Y7J-A nrPDB Length = 365 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 72/316 (22%), Positives = 135/316 (42%), Gaps = 65/316 (20%) Query: 64 YQNLKP---IGSGAQGIVCAAYDAVLDRNVAIK-------KLSRPFQNQTHAKRAYREL- 112 YQ P IG G +V A+K +LS P Q + + RE Sbjct: 93 YQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLS-PEQLEEVREATRRETH 151 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI--QMELDHERMSYL 169 +L + H +II+L++ + E ++LV +LM L + ++ L + + Sbjct: 152 ILRQVAGHPHIITLIDSY------ESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSI 205 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 + +L + LH+ I+HRDLKP NI++ + +++ DFG + + T Y Sbjct: 206 MRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGY 265 Query: 230 RAPEVI------LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 APE++ GY + VD+W+ G I+ ++ G+P Sbjct: 266 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLL---------------------AGSP- 303 Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 P + ++ +R +E + +++ + ++S +DL+S++L +D Sbjct: 304 PFWHRRQILMLRMIMEGQYQFSSPEWDD----------------RSSTVKDLISRLLQVD 347 Query: 344 PAKRISVDDALQHPYI 359 P R++ + ALQHP+ Sbjct: 348 PEARLTAEQALQHPFF 363 >2J90-A nrPDB Length = 304 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 82/318 (25%), Positives = 137/318 (43%), Gaps = 77/318 (24%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY------RELVLMKC 117 Y+ + +GSG IV + A K + + + + ++R RE+ +++ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKK--RRLSSSRRGVSREEIEREVNILRE 85 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQML 174 + H NII+L ++F E DV L++EL+ E L + + L Q+L Sbjct: 86 IRHPNIITLHDIF------ENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQIL 139 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKS----DCTLKILDFGLART--AGTSF---MMTPYVV 225 G+ +LHS I H DLKP NI++ + +K++DFG+A AG F TP V Sbjct: 140 DGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFV 199 Query: 226 TRYYRAPEVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 APE++ LG+ D+WS+G I IL G Sbjct: 200 -----APEIVNYEPLGL----EADMWSIGVIT------YILLSG---------------- 228 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 P + Q T+ N + + + F + F SE A+D + ++LV Sbjct: 229 ASPFLGETKQETLTN-------ISAVNYD--FDEEYFSNTSE-------LAKDFIRRLLV 272 Query: 342 IDPAKRISVDDALQHPYI 359 DP +R+++ +L+H +I Sbjct: 273 KDPKRRMTIAQSLEHSWI 290 >3PPZ-A nrPDB Length = 309 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/194 (29%), Positives = 92/194 (47%), Gaps = 11/194 (5%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA---YRELVLMKCVNHKNIISL 126 IG+G+ G V A D VA+K L + HA+R RE+ +MK + H NI+ Sbjct: 45 IGAGSFGTVHRAEWHGSD--VAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAG-- 184 + T L + L + +LD R + Y + G+ +LH+ Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPP 159 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV-TRYYRAPEVILGMGYKEN 243 I+HRDLK N++V T+K+ DFGL+R ++F+ + T + APEV+ E Sbjct: 160 IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEK 219 Query: 244 VDIWSVGCIMGEMV 257 D++S G I+ E+ Sbjct: 220 SDVYSFGVILWELA 233 >2BRG-A nrPDB Length = 297 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 97/201 (48%), Gaps = 20/201 (9%) Query: 67 LKPIGSGAQGIVCAAYDAVLDRNVAIK--KLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 ++ +G GA G V A + V + VA+K + R + K+ E+ + K +NH+N++ Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKK---EICINKMLNHENVV 68 Query: 125 SLLNVFTPQKTLEEFQDVYLVM----ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 F + Q ++L EL D + E D +R +Q++ G+ +L Sbjct: 69 K----FYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQR---FFHQLMAGVVYL 121 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLA---RTAGTSFMMTPYVVTRYYRAPEVILG 237 H GI HRD+KP N+++ LKI DFGLA R ++ T Y APE++ Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR 181 Query: 238 MGY-KENVDIWSVGCIMGEMV 257 + E VD+WS G ++ M+ Sbjct: 182 REFHAEPVDVWSCGIVLTAML 202 >5DBX-A nrPDB Length = 328 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 105/211 (49%), Gaps = 25/211 (11%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ + IGSGA +V AA VAIK+++ + QT +E+ M +H N+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNV 71 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHER-------MSYLLYQ 172 ++ F + +++LVM+L+ ++ + I +H+ ++ +L + Sbjct: 72 VTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT------PYVVT 226 +L G+ +LH G IHRDLK NI++ D +++I DFG++ T +T +V T Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 227 RYYRAPEVILGM-GYKENVDIWSVGCIMGEM 256 + APEV+ + GY D+WS G E+ Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIEL 216 >5J5T-A nrPDB Length = 370 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 74/305 (24%), Positives = 127/305 (41%), Gaps = 54/305 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ ++ IGSG G V A + AIK + + +E+++MK H NI Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIK--LEPGEDFAVVQQEIIMMKDCKHPNI 63 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCGIKHL 180 ++ + + L ++ ME Q I L +++Y+ + L G+ +L Sbjct: 64 VAYFGSYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYL 117 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 HS G +HRD+K +NI++ + +K+ DFG+ A+ T ++ T Y+ APEV Sbjct: 118 HSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVER 177 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 GY + D+W+VG E+ +LQP + + Sbjct: 178 KGGYNQLCDLWAVGITAIELA-------------------------------ELQPPMFD 206 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM-LVIDPAKRISVDDALQ 355 R + L S F +K+K S + KM L +P KR + + LQ Sbjct: 207 LHPMRALF-------LMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQ 259 Query: 356 HPYIN 360 HP++ Sbjct: 260 HPFVT 264 >5FET-A nrPDB Length = 847 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 101/208 (48%), Gaps = 13/208 (6%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF---QNQTHAKRAYRELVLMKCVNHKNII 124 + IG G G V + A+K +S+ NQ + + RE+ +H II Sbjct: 539 RIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEN--DHPFII 596 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAG 184 L+ F ++ EL DA + + + L + + L ++ I++LH Sbjct: 597 RLVRTFKDSNCFYFLTELVTGGELYDA--IRKLGL-LSKPQAQFYLGSIILAIEYLHERN 653 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 I++RDLKP NI++ +K++DFG A + G ++ + V T +Y APEVILG GY Sbjct: 654 IVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTL---VGTPHYMAPEVILGKGYGCT 710 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 VDIW++G + E + + F G D DQ Sbjct: 711 VDIWALGVCLYEFICGPLPF-GNDQEDQ 737 >3COM-A nrPDB Length = 314 Score = 74.7 bits (182), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 71/298 (23%), Positives = 127/298 (42%), Gaps = 54/298 (18%) Query: 67 LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 L+ +G G+ G V A + VAIK++ ++ + +E+ +M+ + +++ Sbjct: 34 LEKLGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSPHVVKY 89 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME---LDHERMSYLLYQMLCGIKHLHS 182 + D+++VME A ++ +I++ L + ++ +L L G+++LH Sbjct: 90 YGSYFKNT------DLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV-TRYYRAPEVILGMGYK 241 IHRD+K NI++ ++ K+ DFG+A + V+ T ++ APEVI +GY Sbjct: 144 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 203 Query: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 DIWS+G EM K P I + P P F K Sbjct: 204 CVADIWSLGITAIEMAEGK---PPYADIHPMRAIFMIPTNPPPTFRK------------- 247 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P+L+ D+ D + + LV P +R + LQHP++ Sbjct: 248 --------PELWSDNF---------------TDFVKQCLVKSPEQRATATQLLQHPFV 282 >5H2U-A nrPDB Length = 267 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 109/226 (48%), Gaps = 20/226 (8%) Query: 68 KPIGSGAQGIVCAAYDAVL-DR-NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 + +GSG G V ++ + DR VAIK +SR N H + E+ MK + HK+I++ Sbjct: 12 RKLGSGYFGEV---FEGLWKDRVQVAIKVISR--DNLLHQQMLQSEIQAMKKLRHKHILA 66 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERM--SYLL---YQMLCGIKHL 180 L V + VY++ ELM + + D + + S LL +Q+ G+ +L Sbjct: 67 LYAVVSVGDP------VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-FMMTPYVVTRYYRAPEVILGMG 239 S IHRDL NI+V + K+ DFGLAR ++ + + + APE + Sbjct: 121 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH 180 Query: 240 YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y D+WS G ++ EM R ++ +PG + + +V PCP Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP 226 >4JXF-A nrPDB Length = 266 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 132/302 (43%), Gaps = 64/302 (21%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC-VNHKNIISLLN 128 +G G+ V A VAIK + + + + + V + C + H +I+ L N Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 129 VFTPQKTLEEFQDVYLVMEL-----MDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 F E+ VYLV+E+ M+ L ++ ++E + ++Q++ G+ +LHS Sbjct: 75 YF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENE-ARHFMHQIITGMLYLHSH 127 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM---TPYVV--TRYYRAPEVILGM 238 GI+HRDL SN+++ + +KI DFGLA T M Y + T Y +PE+ Sbjct: 128 GILHRDLTLSNLLLTRNMNIKIADFGLA----TQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 + D+WS+GC+ L GR D TV+N + Sbjct: 184 AHGLESDVWSLGCMF------YTLLIGRPPFD--------------------TDTVKNTL 217 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 + + AD E + +A+DL+ ++L +PA R+S+ L HP+ Sbjct: 218 ----------------NKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPF 261 Query: 359 IN 360 ++ Sbjct: 262 MS 263 >4RLP-A nrPDB Length = 288 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 105/226 (46%), Gaps = 21/226 (9%) Query: 64 YQNLKPIGSGAQGIVC---AAYDAVLDRNVAIKKLSRPF--QNQTHAKRAYRELVLMKCV 118 ++ L+ +G G G V A + A+K L + +N E +++ V Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERM------SYLLYQ 172 H I+ L+ F L YL++E + + M+L+ E + + L + Sbjct: 67 KHPFIVDLIYAFQTGGKL------YLILEYLSGG---ELFMQLEREGIFMEDTACFYLAE 117 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRA 231 + + HLH GII+RDLKP NI++ +K+ DFGL + + +T + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 PE+++ G+ VD WS+G +M +M+ F G + +K+++ Sbjct: 178 PEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 223 >6HV0-A nrPDB Length = 416 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 94/309 (30%), Positives = 133/309 (43%), Gaps = 72/309 (23%) Query: 70 IGSGAQGIVCAAYDAVLD-RNVAIKK-LSRPFQNQTHAKRAYRELVLMKCVN-HKNIISL 126 +G GA+G + Y + D R+VA+K+ L F A RE+ L++ + H N+I Sbjct: 16 LGHGAEGTI--VYRGMFDNRDVAVKRILPECFSF------ADREVQLLRESDEHPNVI-- 65 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVI-QMELDHERMS--YLLYQMLCGIKHLHSA 183 F +K +FQ Y+ +EL A L + + Q + H + LL Q G+ HLHS Sbjct: 66 -RYFCTEKD-RQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 184 GIIHRDLKPSNIVVK-----SDCTLKILDFGLARTAGT---SFMMTPYV-VTRYYRAPEV 234 I+HRDLKP NI++ I DFGL + SF V T + APE Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE- 180 Query: 235 ILGMGYKEN----VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 +L KEN VDI+S GC+ + VI + P F K L Sbjct: 181 MLSEDCKENPTYTVDIFSAGCV-------------------FYYVISEGSHP---FGKSL 218 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Q + A + D L P E AR+L+ KM+ +DP KR S Sbjct: 219 Q-----------RQANILLGACSLDCLHPEKHE-----DVIARELIEKMIAMDPQKRPSA 262 Query: 351 DDALQHPYI 359 L+HP+ Sbjct: 263 KHVLKHPFF 271 >1FOT-A nrPDB Length = 318 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/316 (21%), Positives = 134/316 (42%), Gaps = 67/316 (21%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ-THAKRAYRELVLMKCVN 119 L+ +Q L+ +G+G+ G V R A+K L + + + E +++ V Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERM-----SYLLYQML 174 H II + F ++ Q ++++M+ ++ ++ + +R + ++ Sbjct: 65 HPFIIRMWGTF------QDAQQIFMIMDYIEGG--ELFSLLRKSQRFPNPVAKFYAAEVC 116 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-TAGTSFMMTPYVVTRYYRAPE 233 +++LHS II+RDLKP NI++ + +KI DFG A+ ++ + T Y APE Sbjct: 117 LALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCG---TPDYIAPE 173 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y +++D WS G ++ EM+ F + + + K++ Sbjct: 174 VVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILN---------------- 217 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI----- 348 A L FP F + + +DLLS+++ D ++R+ Sbjct: 218 -----------AELRFPPFFNEDV---------------KDLLSRLITRDLSQRLGNLQN 251 Query: 349 SVDDALQHPYIN--VW 362 +D HP+ VW Sbjct: 252 GTEDVKNHPWFKEVVW 267 >3UC3-A nrPDB Length = 361 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 73/299 (24%), Positives = 118/299 (39%), Gaps = 45/299 (15%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 RY +K IGSG G+ D + VA+K + R + RE++ + + H N Sbjct: 21 RYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREIINHRSLRHPN 77 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 I+ V L + EL + +C + D R + Q+L G+ + HS Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGELYE-RICNAGRFSEDEAR--FFFQQLLSGVSYCHS 134 Query: 183 AGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Y Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 Query: 241 KENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 + D+WS G + M+ F + + K I+++ Sbjct: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-------------------- 234 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 L+ PD + + + L+S++ V DPA RIS+ + H + Sbjct: 235 -------LSVKYSIPDDI---------RISPECCHLISRIFVADPATRISIPEIKTHSW 277 >4QMW-A nrPDB Length = 310 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 89/198 (44%), Gaps = 10/198 (5%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ IG G+ G V D + VAIK + VL +C + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYV 89 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLCGIKHLH 181 + L +++ME + L + LD +++ +L ++L G+ +LH Sbjct: 90 TKYYGSYLKDTKL------WIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 143 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 S IHRD+K +N+++ +K+ DFG+A + T +V T ++ APEVI Y Sbjct: 144 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 203 Query: 241 KENVDIWSVGCIMGEMVR 258 DIWS+G E+ R Sbjct: 204 DSKADIWSLGITAIELAR 221 >4LG4-A nrPDB Length = 299 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/301 (23%), Positives = 127/301 (42%), Gaps = 54/301 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ +G G+ G V A + VAIK++ ++ + +E+ +M+ + + Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYV 68 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME---LDHERMSYLLYQMLCGIKH 179 + + D+++VME A ++ +I++ L + ++ +L L G+++ Sbjct: 69 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 122 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV-TRYYRAPEVILGM 238 LH IHR++K NI++ ++ K+ DFG+A + V+ T ++ APEVI + Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 182 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 GY DIWS+G EM K P I + P P F K Sbjct: 183 GYNCVADIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNPPPTFRK---------- 229 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 P+L+ D D + K LV +P +R + LQHP+ Sbjct: 230 -----------PELWSDDF---------------TDFVKKCLVKNPEQRATATQLLQHPF 263 Query: 359 I 359 I Sbjct: 264 I 264 >4AF3-A nrPDB Length = 292 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 70/301 (23%), Positives = 129/301 (42%), Gaps = 59/301 (19%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK----RAYRELVLMKCVNHKNI 123 +P+G G G V A + VA+K L F++Q + + RE+ + ++H NI Sbjct: 29 RPLGKGKFGNVYLAREKKSHFIVALKVL---FKSQIEKEGVEHQLRREIEIQAHLHHPNI 85 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERMSYLLYQMLCGIKHL 180 + L N F ++ +YL++E L + +Q D +R + ++ ++ + + Sbjct: 86 LRLYNYFYDRRR------IYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H +IHRD+KP N+++ LKI DFG + A S T Y PE+I G + Sbjct: 140 HGKKVIHRDIKPENLLLGLKGELKIADFGWSVHA-PSLRRKTMCGTLDYLPPEMIEGRMH 198 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 E VD+W +G + E++ F + + + ++++ Sbjct: 199 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVK----------------------- 235 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 L FP P + A+DL+SK+L +P++R+ + HP++ Sbjct: 236 ----VDLKFPASVP---------------TGAQDLISKLLRHNPSERLPLAQVSAHPWVR 276 Query: 361 V 361 Sbjct: 277 A 277 >2UV2-A nrPDB Length = 325 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 98/217 (45%), Gaps = 22/217 (10%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ + +G GA G V A + A K + +++ + E+ ++ +H NI Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDT--KSEEELEDYMVEIDILASCDHPNI 96 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD----HERMSYLLYQMLCGIKH 179 + LL+ F + L ++++E + +EL+ ++ + Q L + + Sbjct: 97 VKLLDAFYYENNL------WILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNY 150 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVIL-- 236 LH IIHRDLK NI+ D +K+ DFG+ A+ T ++ T Y+ APEV++ Sbjct: 151 LHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 210 Query: 237 ---GMGYKENVDIWSVGCIMGEMVR----HKILFPGR 266 Y D+WS+G + EM H L P R Sbjct: 211 TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMR 247 >5D7A-A nrPDB Length = 308 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 95/204 (46%), Gaps = 23/204 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G+G G V + AIK + + K+ +L K +H+NI + Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEIN--MLKKYSHHRNIATYYGA 82 Query: 130 FTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAG 184 F + ++LVME A ++ +I+ L E ++Y+ ++L G+ HLH Sbjct: 83 FIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHK 142 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFG----LARTAG--TSFMMTPYVVTRYYRAPEVIL-- 236 +IHRD+K N+++ + +K++DFG L RT G +F+ TP Y+ APEVI Sbjct: 143 VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTP-----YWMAPEVIACD 197 Query: 237 ---GMGYKENVDIWSVGCIMGEMV 257 Y D+WS+G EM Sbjct: 198 ENPDATYDFKSDLWSLGITAIEMA 221 >6AO5-A nrPDB Length = 362 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 126/298 (42%), Gaps = 54/298 (18%) Query: 67 LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 L+ +G G+ G V A + VAIK++ ++ + +E+ +M+ + ++ Sbjct: 15 LEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYVVKY 70 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME---LDHERMSYLLYQMLCGIKHLHS 182 + D+++VME A ++ +I++ L + ++ +L L G+++LH Sbjct: 71 YGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGYK 241 IHR++K NI++ ++ K+ DFG+A + T + T ++ APEVI +GY Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYN 184 Query: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 DIWS+G EM K P I + P P F K Sbjct: 185 CVADIWSLGITSIEMAEGK---PPYADIHPMRAIFMIPTNPPPTFRK------------- 228 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P+L+ D D + K LV +P +R + LQHP+I Sbjct: 229 --------PELWSDDF---------------TDFVKKCLVKNPEQRATATQLLQHPFI 263 >4YHJ-A nrPDB Length = 584 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/233 (24%), Positives = 106/233 (45%), Gaps = 12/233 (5%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR-AYRELVLMKCVNHKN 122 +++ + +G G G VCA + A KKL + + + A E +++ V + Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 ++SL + + L LV+ +M+ ++ + D +R + ++ CG+ Sbjct: 247 VVSLAYAYETKDAL------CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 + L I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 Y + D W +GC++ EM++ F +W +V +++ E+ +K Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKF 413 >3UIU-A nrPDB Length = 306 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 63/235 (26%), Positives = 109/235 (46%), Gaps = 38/235 (16%) Query: 55 DSTFTVLKRY----QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR 110 ++ +TV KR+ + ++ IGSG G V A + + I+++ + N+ +A R Sbjct: 1 ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRV--KYNNE----KAER 54 Query: 111 ELVLMKCVNHKNIISLLNVF--------TPQKTLE---------------EFQDVYLVME 147 E+ + ++H NI+ + T +LE + + +++ ME Sbjct: 55 EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQME 114 Query: 148 LMD-ANLCQVIQM----ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT 202 D L Q I+ +LD L Q+ G+ ++HS +IHRDLKPSNI + Sbjct: 115 FCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ 174 Query: 203 LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 +KI DFGL + T T Y +PE I Y + VD++++G I+ E++ Sbjct: 175 VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >3DB8-A nrPDB Length = 317 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 21/204 (10%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCV 118 +KRY + +G G D A K + + + H K + E+ + K + Sbjct: 40 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSL 99 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER--------MSYLL 170 ++ +++ F E+ VY+V+E+ C+ + H+R Y + Sbjct: 100 DNPHVVGFHGFF------EDDDFVYVVLEI-----CRRRSLLELHKRRKAVTEPEARYFM 148 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYY 229 Q + G+++LH+ +IHRDLK N+ + D +KI DFGLA + T Y Sbjct: 149 RQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNY 208 Query: 230 RAPEVILGMGYKENVDIWSVGCIM 253 APEV+ G+ VDIWS+GCI+ Sbjct: 209 IAPEVLCKKGHSFEVDIWSLGCIL 232 >4GS6-A nrPDB Length = 315 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 74/246 (30%), Positives = 109/246 (44%), Gaps = 42/246 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA G+VC A ++VAIK++ ++++ K EL + VNH NI+ L Sbjct: 17 VGRGAFGVVCKA--KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYGA 70 Query: 130 FTPQKTLEEFQDVYLVMELMDA-NLCQVIQME------LDHERMSYLLYQMLCGIKHLHS 182 V LVME + +L V+ MS+ L Q G+ +LHS Sbjct: 71 C--------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCL-QCSQGVAYLHS 121 Query: 183 ---AGIIHRDLKPSNIV-VKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 +IHRDLKP N++ V LKI DFG A T MT + + APEV G Sbjct: 122 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNKGSAAWMAPEVFEGS 179 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR-NY 297 Y E D++S G I+ E++ + K +++G P M + R Sbjct: 180 NYSEKCDVFSWGIILWEVITRR-------------KPFDEIGGPAFRIMWAVHNGTRPPL 226 Query: 298 VENRPK 303 ++N PK Sbjct: 227 IKNLPK 232 >2YZA-A nrPDB Length = 276 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 120/298 (40%), Gaps = 59/298 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + VA+K L+R ++ + RE+ +K H +II L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 129 VF-TPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V TP D ++VME + +C+ ++E R L Q+L + + H Sbjct: 79 VISTPT-------DFFMVMEYVSGGELFDYICKHGRVEEMEARR--LFQQILSAVDYCHR 129 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 ++HRDLKP N+++ + KI DFGL+ + + Y APEVI G Y Sbjct: 130 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAG 189 Query: 243 -NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 VDIWS G I+ ++ + F P KK +R V Sbjct: 190 PEVDIWSCGVILYALLCGTLPFDDEH---------------VPTLFKK----IRGGVFYI 230 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P+Y N+ A+ LL ML +DP KR ++ D +H + Sbjct: 231 PEYL-------------------NRSVAT----LLMHMLQVDPLKRATIKDIREHEWF 265 >3C51-A nrPDB Length = 543 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 97/199 (48%), Gaps = 24/199 (12%) Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE-------RM 166 ++ V+ + I+SL F E D+ LVM +M+ + +D + R Sbjct: 238 ILAKVHSRFIVSLAYAF------ETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRA 291 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA--RTAGTSFMMTPYV 224 + Q++ G++HLH II+RDLKP N+++ D ++I D GLA AG + Y Sbjct: 292 IFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQT-KTKGYA 350 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGR----DYIDQWNKVIEQLG 280 T + APE++LG Y +VD +++G + EM+ + F R + + +V+EQ Sbjct: 351 GTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAV 410 Query: 281 TPCPEFMKKLQPTVRNYVE 299 T + K P +++ E Sbjct: 411 T----YPDKFSPASKDFCE 425 >2A1A-B nrPDB Length = 284 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 104/218 (47%), Gaps = 25/218 (11%) Query: 59 TVLKRY----QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 TV KR+ + ++ IGSG G V A + + IK++ + N+ +A RE+ Sbjct: 4 TVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRV--KYNNE----KAEREVKA 57 Query: 115 MKCVNHKNIISLLNVF----------TPQKTLEEFQDVYLVMELMD-ANLCQVIQM---- 159 + ++H NI+ + + + + + +++ ME D L Q I+ Sbjct: 58 LAKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGE 117 Query: 160 ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 219 +LD L Q+ G+ ++HS +I+RDLKPSNI + +KI DFGL + Sbjct: 118 KLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK 177 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 T T Y +PE I Y + VD++++G I+ E++ Sbjct: 178 RTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >4K33-A nrPDB Length = 325 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 23/212 (10%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIK------KLSRPFQNQTHAKRAYRELVLMKCVN-H 120 KP+G GA G V A +D++ A K K+ + E+ +MK + H Sbjct: 42 KPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 101 Query: 121 KNIISLLNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELD-----HERMSY---- 168 KNII+LL T P L E+ + E + A + D E++++ Sbjct: 102 KNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLV 161 Query: 169 -LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 YQ+ G+++L S IHRDL N++V D +KI DFGLAR R Sbjct: 162 SCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGR 221 Query: 228 Y---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 + APE + Y D+WS G ++ E+ Sbjct: 222 LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 253 >3KA0-A nrPDB Length = 320 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 128/299 (42%), Gaps = 52/299 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL-MKCVNHKNIISLLN 128 +G G G V ++ A+K L +A RE+ L + +I+ +++ Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 76 Query: 129 VFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKHLHSA 183 V+ + + + +VME +D L IQ D ER S ++ + I++LHS Sbjct: 77 VY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 134 Query: 184 GIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 I HRD+KP N++ S + LK+ DFG A+ + +T T YY APEV+ Y Sbjct: 135 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKY 194 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 ++ D+WS+G IM IL G P F + ++ Sbjct: 195 DKSCDMWSLGVIM------YILLCGY-----------------PPFYSNHGLAISPGMKT 231 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 R + FP P SE + + + L+ +L +P +R+++ + + HP+I Sbjct: 232 RIRMGQYEFPN-------PEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >5EG3-A nrPDB Length = 334 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 95/218 (43%), Gaps = 35/218 (16%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 KP+G GA G V A +D++ VA+K L + + E+ +MK + Sbjct: 41 KPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLVSEMEMMKMIGK 99 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ------MELD-------HERM 166 HKNII+LL T L +V NL + ++ MEL E+M Sbjct: 100 HKNIINLLGACTQDGPL-----YVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQM 154 Query: 167 SY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 ++ YQ+ G+++L S IHRDL N++V + +KI DFGLAR Sbjct: 155 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFK 214 Query: 222 PYVVTRY---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 R + APE + Y D+WS G +M E+ Sbjct: 215 ETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 252 >1NY3-A nrPDB Length = 400 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 78/303 (25%), Positives = 128/303 (42%), Gaps = 60/303 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM----KCVNHKNIIS 125 +G G G V ++ A+K L +A RE+ L +C + I+ Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 Query: 126 LL-NVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKH 179 + N++ +K L +VME +D L IQ D ER S ++ + I++ Sbjct: 123 VYENLYAGRKCL------LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 180 LHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 LHS I HRD+KP N++ S + LK+ DFG A+ + +T T YY APEV+ Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y ++ D+WS+G IM IL G P F + Sbjct: 237 PEKYDKSCDMWSLGVIM------YILLCG-----------------YPPFYSNHGLAISP 273 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 ++ R + FP P SE + + + L+ +L +P +R+++ + + H Sbjct: 274 GMKTRIRMGQYEFPN-------PEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 Query: 357 PYI 359 P+I Sbjct: 323 PWI 325 >6ED6-A nrPDB Length = 415 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 105/233 (45%), Gaps = 18/233 (7%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY--RELVLMKCVNHK 121 Y +K IG GA G V + A+K LS+ F+ + A+ E +M N Sbjct: 90 YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSK-FEMIKRSDSAFFWEERDIMAFANSP 148 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI-QMELDHERMSYLLYQMLCGIKH 179 ++ L F + L Y+VME M +L ++ ++ + + +++ + Sbjct: 149 WVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDA 202 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM--TPYVVTRYYRAPEVILG 237 +HS G+IHRD+KP N+++ LK+ DFG + M+ V T Y +PEV+ Sbjct: 203 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS 262 Query: 238 MG----YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC-PE 285 G Y D WSVG + EM+ F + ++K+++ + C PE Sbjct: 263 QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPE 315 >2OZA-A nrPDB Length = 356 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 78/303 (25%), Positives = 128/303 (42%), Gaps = 60/303 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM----KCVNHKNIIS 125 +G G G V ++ A+K L +A RE+ L +C + I+ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 78 Query: 126 LL-NVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKH 179 + N++ +K L +VME +D L IQ D ER S ++ + I++ Sbjct: 79 VYENLYAGRKCL------LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 180 LHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 LHS I HRD+KP N++ S + LK+ DFG A+ + +T T YY APEV+ Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 192 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y ++ D+WS+G IM IL G P F + Sbjct: 193 PEKYDKSCDMWSLGVIM------YILLCGY-----------------PPFYSNHGLAISP 229 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 ++ R + FP P SE + + + L+ +L +P +R+++ + + H Sbjct: 230 GMKTRIRMGQYEFPN-------PEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNH 278 Query: 357 PYI 359 P+I Sbjct: 279 PWI 281 >2OU7-A nrPDB Length = 335 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 75/152 (49%), Gaps = 20/152 (13%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS--- 167 E+ + + + H++++ F E+ V++V+EL C+ + H+R Sbjct: 91 EISIHRSLAHQHVVGFHGFF------EDNDFVFVVLEL-----CRRRSLLELHKRRKALT 139 Query: 168 -----YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 222 Y L Q++ G ++LH +IHRDLK N+ + D +KI DFGLA Sbjct: 140 EPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKK 199 Query: 223 YVV-TRYYRAPEVILGMGYKENVDIWSVGCIM 253 + T Y APEV+ G+ VD+WS+GCIM Sbjct: 200 VLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIM 231 >6GVJ-A nrPDB Length = 429 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 103/243 (42%), Gaps = 58/243 (23%) Query: 140 QDVYLVMELMDANLCQVIQMELD---HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 Q +Y+VME + +L ++ + ER SY ML + +H GI+H DLKP+N + Sbjct: 217 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 275 Query: 197 VKSDCTLKILDFGLA---RTAGTSFMMTPYVVTRYYRAPEVILGM-GYKEN--------- 243 + D LK++DFG+A + TS + V T Y PE I M +EN Sbjct: 276 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 334 Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 D+WS+GCI+ M K F ++I Q+ KL + E Sbjct: 335 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAIIDPNHEIE- 376 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 FPD + +D+L L DP +RIS+ + L HPY+ + Sbjct: 377 ----------FPD-----------IPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQ 415 Query: 363 YDP 365 P Sbjct: 416 THP 418 >3QA8-A nrPDB Length = 676 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/199 (30%), Positives = 88/199 (44%), Gaps = 15/199 (7%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G+G G V VAIK+ + + +R E+ +MK +NH N++S V Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNR-ERWCLEIQIMKKLNHPNVVSAREV 80 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQ--VIQME----LDHERMSYLLYQMLCGIKHLHSA 183 + L L ME + + + Q E L + LL + +++LH Sbjct: 81 PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHEN 140 Query: 184 GIIHRDLKPSNIVVK---SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 IIHRDLKP NIV++ KI+D G A+ + T +V T Y APE++ Y Sbjct: 141 RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLEQKKY 200 Query: 241 KENVDIWSVG-----CIMG 254 VD WS G CI G Sbjct: 201 TVTVDYWSFGTLAFECITG 219 >4PL5-B nrPDB Length = 435 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 86/309 (27%), Positives = 132/309 (42%), Gaps = 72/309 (23%) Query: 70 IGSGAQGIVCAAYDAVLD-RNVAIKK-LSRPFQNQTHAKRAYRELVLMKCVN-HKNIISL 126 +G GA+G + Y + D R+VA+K+ L F A RE+ L++ + H N+I Sbjct: 35 LGHGAEGTI--VYKGMFDNRDVAVKRILPECFSF------ADREVQLLRESDEHPNVI-- 84 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVI-QMELDHERMS--YLLYQMLCGIKHLHSA 183 F +K +FQ Y+ +EL A L + + Q + H + LL+Q G+ HLHS Sbjct: 85 -RYFCTEKD-RQFQ--YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSL 140 Query: 184 GIIHRDLKPSNIVVK-----SDCTLKILDFGLARTAGT---SFMMTPYV-VTRYYRAPEV 234 I+HRDLKP NI++ I DFGL + SF V T + APE Sbjct: 141 NIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE- 199 Query: 235 ILGMGYKEN----VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 +L K+N VDI+S GC+ ++ G+ Q N ++ C Sbjct: 200 MLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDC------- 252 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 F +D + + AR+L+ KM+ +DP +R S Sbjct: 253 ---------------------------FHSDKHEDVI----ARELIEKMIAMDPQQRPSA 281 Query: 351 DDALQHPYI 359 L+HP+ Sbjct: 282 KHVLKHPFF 290 >2JDO-A nrPDB Length = 342 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 80/339 (23%), Positives = 140/339 (41%), Gaps = 40/339 (11%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 122 + LK +G G G V + R A+K L + + E +++ H Sbjct: 12 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 71 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-----QMELDHERMSYLLYQMLCGI 177 + +L F L VME AN ++ + ER + +++ + Sbjct: 72 LTALKYAFQTHDRL------CFVMEY--ANGGELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPEVIL 236 ++LHS +++RD+K N+++ D +KI DFGL + M + T Y APEV+ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y VD W +G +M EM+ ++ F +D+ ++ E + F + L P ++ Sbjct: 184 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELILMEEIRFPRTLSPEAKS 239 Query: 297 YVENRPKYAGLTFPKLFPDSLF---PADS----EHNKLKASQARDLLSKMLVIDPAKRIS 349 + AGL K P P+D+ EH + +D++ K L+ P + Sbjct: 240 LL------AGLL--KKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL--PPFKPQ 289 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDK----QLDERE 384 V + Y + + + PP YD +LD+RE Sbjct: 290 VTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRE 328 >3ALO-A nrPDB Length = 327 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 44/273 (16%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNI 123 ++L IG GA G V + +A+K++ R ++ K+ +L V+M+ + I Sbjct: 25 KDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVVMRSSDCPYI 83 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ-------VIQMELDHERMSYLLYQMLCG 176 + + D ++ MELM + + V+ + E + + + Sbjct: 84 VQFYGALFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKA 137 Query: 177 IKHL-HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + HL + IIHRD+KPSNI++ +K+ DFG++ S T R Y APE I Sbjct: 138 LNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERI 197 Query: 236 ----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL-----GTPCPEF 286 GY D+WS+G + E+ + +P +WN V +QL G P P+ Sbjct: 198 DPSASRQGYDVRSDVWSLGITLYELATGRFPYP------KWNSVFDQLTQVVKGDP-PQL 250 Query: 287 M----KKLQPTVRNYV--------ENRPKYAGL 307 ++ P+ N+V RPKY L Sbjct: 251 SNSEEREFSPSFINFVNLCLTKDESKRPKYKEL 283 >4J52-A nrPDB Length = 293 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 75/152 (49%), Gaps = 20/152 (13%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER----- 165 E+ + + + H++++ F E+ V++V+EL C+ + H+R Sbjct: 64 EISIHRSLAHQHVVGFHGFF------EDNDFVFVVLEL-----CRRRSLLELHKRRKALT 112 Query: 166 ---MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 222 Y L Q++ G ++LH +IHRDLK N+ + D +KI DFGLA Sbjct: 113 EPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKK 172 Query: 223 YVV-TRYYRAPEVILGMGYKENVDIWSVGCIM 253 + T Y APEV+ G+ VD+WS+GCIM Sbjct: 173 VLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIM 204 >3HDN-A nrPDB Length = 373 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 100/226 (44%), Gaps = 22/226 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLMKCVNHK 121 + LK IG G+ G V A + A+K L + + + VL+K V H Sbjct: 40 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 99 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGIK 178 ++ L F L Y V++ ++ L +Q E R + ++ + Sbjct: 100 FLVGLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 153 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR------TAGTSFMMTPYVVTRYYRAP 232 +LHS I++RDLKP NI++ S + + DFGL + + ++F TP Y AP Sbjct: 154 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTP-----EYLAP 208 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 EV+ Y VD W +G ++ EM+ F R+ + ++ ++ + Sbjct: 209 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK 254 >3KUL-B nrPDB Length = 325 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 85/201 (42%), Gaps = 18/201 (8%) Query: 68 KPIGSGAQGIVCAAYDAV---LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 K IGSG G VC V D VAIK L + + + E +M +H NII Sbjct: 55 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQFDHPNII 113 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQML----CGIKHL 180 L V T + +V E M+ D + L ML G+++L Sbjct: 114 RLEGVVTRGRL------AMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYL 167 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVIL 236 G +HRDL N++V S+ K+ DFGL+R ++ T + + APE I Sbjct: 168 SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA 227 Query: 237 GMGYKENVDIWSVGCIMGEMV 257 + D+WS G +M E++ Sbjct: 228 FRTFSSASDVWSFGVVMWEVL 248 >3LM0-A nrPDB Length = 327 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 52/197 (26%), Positives = 83/197 (42%), Gaps = 41/197 (20%) Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGLARTAGTSFMMTPYVV 225 L+ Q+L G+ +LH I+H DLKP NI++ S L KI+DFG++R G + + + Sbjct: 136 LIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMG 195 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y APE++ D+W++G I ++ H F G D Sbjct: 196 TPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN----------------- 238 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 Q T N + Y+ TF + + A D + +LV +P Sbjct: 239 -----QETYLNISQVNVDYSEETFSSV----------------SQLATDFIQSLLVKNPE 277 Query: 346 KRISVDDALQHPYINVW 362 KR + + L H ++ W Sbjct: 278 KRPTAEICLSHSWLQQW 294 >3HMP-A nrPDB Length = 342 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 104/243 (42%), Gaps = 58/243 (23%) Query: 140 QDVYLVMELMDANLCQVIQMELD---HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 Q +Y+VME + +L ++ + ER SY ML + +H GI+H DLKP+N + Sbjct: 129 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 187 Query: 197 VKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVILGM-GYKEN--------- 243 + D LK++DFG+A TS + V T Y PE I M +EN Sbjct: 188 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 246 Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 D+WS+GCI+ M K F ++I Q+ KL + P Sbjct: 247 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAII------DP 283 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + + FP + L +D+L L DP +RIS+ + L HPY+ + Sbjct: 284 NHE-IEFPDIPEKDL---------------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 327 Query: 363 YDP 365 P Sbjct: 328 THP 330 >6HXF-B nrPDB Length = 302 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 113/261 (43%), Gaps = 25/261 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ + +G GA G V A + A K + +++ + E+ ++ +H I Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIET--KSEEELEDYIVEIEILATCDHPYI 78 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH----ERMSYLLYQMLCGIKH 179 + LL + L ++++E I +ELD ++ + QML + Sbjct: 79 VKLLGAYYHDGKL------WIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 132 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGM 238 LHS IIHRDLK N+++ + +++ DFG+ A+ T ++ T Y+ APEV++ Sbjct: 133 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 192 Query: 239 GYKEN-----VDIWSVGCIMGEMVR----HKILFPGRDYIDQWNKVIEQLGTPCP---EF 286 K+ DIWS+G + EM + H L P R + L TP EF Sbjct: 193 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 252 Query: 287 MKKLQPTVRNYVENRPKYAGL 307 L+ + E RP A L Sbjct: 253 RDFLKIALDKNPETRPSAAQL 273 >2PSQ-A nrPDB Length = 370 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 94/213 (44%), Gaps = 25/213 (11%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 KP+G G G V A +D++ VA+K L + + E+ +MK + Sbjct: 87 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLVSEMEMMKMIGK 145 Query: 120 HKNIISLLNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELD-----HERMSY--- 168 HKNII+LL T P + E+ + E + A ++ D E+M++ Sbjct: 146 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDL 205 Query: 169 --LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 YQ+ G+++L S IHRDL N++V + +KI DFGLAR Sbjct: 206 VSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG 265 Query: 227 RY---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 R + APE + Y D+WS G +M E+ Sbjct: 266 RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 298 >2R2P-A nrPDB Length = 295 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 87/201 (43%), Gaps = 18/201 (8%) Query: 70 IGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 IG+G G VC+ + + VAIK L + + + E +M +H NII L Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHPNIIHL 88 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGI----KHLHS 182 V T K V +V E M+ + D + L ML GI K+L Sbjct: 89 EGVVTKSKP------VMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSD 142 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVILGM 238 G +HRDL NI++ S+ K+ DFGL+R ++ + + APE I Sbjct: 143 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFR 202 Query: 239 GYKENVDIWSVGCIMGEMVRH 259 + D+WS G +M E+V + Sbjct: 203 KFTSASDVWSYGIVMWEVVSY 223 >1S9I-A nrPDB Length = 354 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 58/212 (27%), Positives = 98/212 (46%), Gaps = 20/212 (9%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++ + +G+G G+V ++ R + ++ +NQ REL ++ N Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQI-----IRELQVLHECN 72 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDHERMSYLLYQMLCG 176 I+ F ++ + ME MD +L QV++ + E + + +L G Sbjct: 73 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 126 Query: 177 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + +L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y APE + Sbjct: 127 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMAPERL 185 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRD 267 G Y DIWS+G + E+ + P D Sbjct: 186 QGTHYSVQSDIWSMGLSLVELAVGRYPIPPPD 217 >3TT0-A nrPDB Length = 382 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 25/213 (11%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 KP+G GA G V A LD++ VA+K L + + E+ +MK + Sbjct: 75 KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGK 133 Query: 120 HKNIISLLNVFT---PQKTLEEFQDVYLVMELMDA----------NLCQVIQMELDHERM 166 HKNII+LL T P + E+ + E + A N + +L + + Sbjct: 134 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDL 193 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 194 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 253 Query: 227 RY---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 R + APE + Y D+WS G ++ E+ Sbjct: 254 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 286 >3GQL-A nrPDB Length = 326 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 93/213 (43%), Gaps = 25/213 (11%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 KP+G GA G V A LD++ VA+K L + + E+ +MK + Sbjct: 34 KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGK 92 Query: 120 HKNIISLLNVFT---PQKTLEEFQDVYLVMELMDA----------NLCQVIQMELDHERM 166 HKNII+LL T P + E+ + E + A N + +L + + Sbjct: 93 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 152 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 153 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 212 Query: 227 RY---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 R + APE + Y D+WS G ++ E+ Sbjct: 213 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 245 >5HVK-A nrPDB Length = 315 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 94/208 (45%), Gaps = 29/208 (13%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G + +K+L R F +T + +E+ +M+C+ H N++ + V Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR-FDEETQ-RTFLKEVKVMRCLEHPNVLKFIGV 79 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE-----RMSYLLYQMLCGIKHLHSAG 184 K L + E + + I +D + R+S+ + G+ +LHS Sbjct: 80 LYKDKRLN------FITEYIKGGTLRGIIKSMDSQYPWSQRVSFA-KDIASGMAYLHSMN 132 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLART--------AGTSFMMTP-----YVVTR--YY 229 IIHR+L N +V+ + + + DFGLAR G + P Y V Y+ Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMV 257 APE+I G Y E VD++S G ++ E++ Sbjct: 193 MAPEMINGRSYDEKVDVFSFGIVLCEII 220 >5VD3-A nrPDB Length = 311 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 62/240 (25%), Positives = 103/240 (42%), Gaps = 14/240 (5%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + +Q L +G G+ G V R A+K+ PF+ R L + +H+ Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARK-----LAEVGSHE 111 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANL---CQVIQMELDHERMSYLLYQMLCGIK 178 + ++ EE +YL EL +L C+ L ++ L L + Sbjct: 112 KVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALA 171 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 HLHS G++H D+KP+NI + K+ DFGL GT+ Y APE++ G Sbjct: 172 HLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG- 230 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 Y D++S+G + E+ + L G + W ++ + G PEF L +R+ + Sbjct: 231 SYGTAADVFSLGLTILEVACNMELPHGG---EGWQQLRQ--GYLPPEFTAGLSSELRSVL 285 >4U41-A nrPDB Length = 332 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 21/161 (13%) Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LDHERMS 167 +L K +H+NI + F + ++LVME A ++ +++ L + ++ Sbjct: 73 MLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIA 132 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG----LARTAG--TSFMMT 221 Y+ ++L G+ HLH +IHRD+K N+++ + +K++DFG L RT G +F+ T Sbjct: 133 YISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGT 192 Query: 222 PYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMV 257 P Y+ APEVI Y D+WS G EM Sbjct: 193 P-----YWMAPEVIACDENPDATYDYRSDLWSCGITAIEMA 228 >4KIK-B nrPDB Length = 677 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 89/199 (44%), Gaps = 15/199 (7%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G+G G V ++ +AIK+ + + +R E+ +M+ + H N+++ +V Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNR-ERWCLEIQIMRRLTHPNVVAARDV 85 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQ--VIQME----LDHERMSYLLYQMLCGIKHLHSA 183 + L L ME + + Q E L + LL + +++LH Sbjct: 86 PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHEN 145 Query: 184 GIIHRDLKPSNIVVKSD---CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 IIHRDLKP NIV++ KI+D G A+ + T +V T Y APE++ Y Sbjct: 146 RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKY 205 Query: 241 KENVDIWSVG-----CIMG 254 VD WS G CI G Sbjct: 206 TVTVDYWSFGTLAFECITG 224 >4UY9-A nrPDB Length = 323 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 74/247 (29%), Positives = 110/247 (44%), Gaps = 29/247 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR-ELVLMKCVNHKNIISLL 127 IG G G V A+ + VA+K P ++ + R E L + H NII+L Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGI 185 V + L LVME L +V+ + + + + Q+ G+ +LH I Sbjct: 75 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 186 ---IHRDLKPSNIVVK--------SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV 234 IHRDLK SNI++ S+ LKI DFGLAR + M+ T + APEV Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAPEV 187 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-----YIDQWNKVIEQLGTPCPEFMKK 289 I + + D+WS G ++ E++ ++ F G D Y NK+ + + CPE K Sbjct: 188 IRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 247 Query: 290 LQPTVRN 296 L N Sbjct: 248 LMEDCWN 254 >4XEY-B nrPDB Length = 408 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 64/264 (24%), Positives = 120/264 (45%), Gaps = 28/264 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G V VA+K L ++ + +E +MK + H N++ LL V Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 189 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAG 184 T + Y++ E M NL ++ E++ + Y+ Q+ +++L Sbjct: 190 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 243 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGYK 241 IHRDL N +V + +K+ DFGL+R T T + ++ + APE + + Sbjct: 244 FIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNKFS 302 Query: 242 ENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQPTVR 295 D+W+ G ++ E+ + + +PG D + Q +++E ++ P CPE + +L Sbjct: 303 IKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACW 361 Query: 296 NYV-ENRPKYAGL--TFPKLFPDS 316 + +RP +A + F +F +S Sbjct: 362 QWNPSDRPSFAEIHQAFETMFQES 385 >6NPU-A nrPDB Length = 298 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/264 (24%), Positives = 120/264 (45%), Gaps = 28/264 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G V VA+K L ++ + +E +MK + H N++ LL V Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 90 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAG 184 T + Y++ E M NL ++ E++ + Y+ Q+ +++L Sbjct: 91 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 144 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGYK 241 IHRDL N +V + +K+ DFGL+R T T + ++ + APE + + Sbjct: 145 FIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNKFS 203 Query: 242 ENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWNKVIEQ---LGTP--CPEFMKKLQPTVR 295 D+W+ G ++ E+ + + +PG D + Q +++E+ + P CPE + +L Sbjct: 204 IKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACW 262 Query: 296 NYV-ENRPKYAGL--TFPKLFPDS 316 + +RP +A + F +F +S Sbjct: 263 QWNPSDRPSFAEIHQAFETMFQES 286 >3DKO-A nrPDB Length = 318 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 102/241 (42%), Gaps = 31/241 (12%) Query: 70 IGSGAQGIVCAA---YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 IG+G G VC+ D VAIK L + + + E +M +H N++ L Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHPNVVHL 109 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGI----KHLHS 182 V T K V +V+E M+ + D + L ML GI ++L Sbjct: 110 EGVVTRGKP------VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLAD 163 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----GTSFMMTPYVVTRYYRAPEVILGM 238 G +HRDL NI+V S+ K+ DFGL+R + T + + APE I Sbjct: 164 MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYR 223 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN----KVIEQ---LGTP--CPEFMKK 289 + D+WS G +M E++ + R Y D N K IE+ L P CP + + Sbjct: 224 KFTSASDVWSYGIVMWEVMS----YGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQ 279 Query: 290 L 290 L Sbjct: 280 L 280 >5VO2-A nrPDB Length = 300 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 72/251 (28%), Positives = 107/251 (42%), Gaps = 32/251 (12%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +L+ +GSGAQG V VA+KK+ +T K ++ + H NII+ Sbjct: 16 DLQWVGSGAQGAVFLG--RFHGEEVAVKKVRD--LKETDIKH-------LRKLKHPNIIT 64 Query: 126 LLNVFTPQK---TLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V T L EF + E++ A + +D + G+ +LH Sbjct: 65 FKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS------MGIAGGMNYLHL 118 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 IIHRDLK N+++ D +KI DFG ++ + T + APEVI E Sbjct: 119 HKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE 178 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQ----WNKVIEQLGTP----CPEFMKKLQPTV 294 VDIWS G ++ E++ +I P +D +D W L P CP+ K L Sbjct: 179 KVDIWSFGVVLWELLTGEI--PYKD-VDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC 235 Query: 295 RNYV-ENRPKY 304 N NRP + Sbjct: 236 WNSKPRNRPSF 246 >6E9W-A nrPDB Length = 443 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 17/225 (7%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY--RELVLMKCVNHK 121 Y+ +K IG GA G V + A+K LS+ F+ + A+ E +M N Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSK-FEMIKRSDSAFFWEERDIMAFANSP 162 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI-QMELDHERMSYLLYQMLCGIKH 179 ++ L F + L Y+VME M +L ++ ++ + + +++ + Sbjct: 163 WVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDA 216 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM--TPYVVTRYYRAPEVILG 237 +HS G IHRD+KP N+++ LK+ DFG M+ V T Y +PEV+ Sbjct: 217 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS 276 Query: 238 MG----YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 G Y D WSVG + EM+ F + ++K++ Sbjct: 277 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNH 321 >5KKR-C nrPDB Length = 395 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 74/316 (23%), Positives = 137/316 (43%), Gaps = 42/316 (13%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++ + +G+G G+V V+ R + ++ +NQ REL ++ N Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 124 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCG 176 I+ F ++ + ME MD +L QV++ + + + + ++ G Sbjct: 125 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 178 Query: 177 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + +L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y +PE + Sbjct: 179 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 237 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTPCPEFMKKLQP 292 G Y DIWS+G + EM + P D + + +E P + Sbjct: 238 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGR 297 Query: 293 TVRNY-VENRPKYAGLTF--------PKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 + +Y +++RP A P P ++F + + +D ++K L+ + Sbjct: 298 PLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVF----------SLEFQDFVNKCLIKN 347 Query: 344 PAKRISVDDALQHPYI 359 PA+R + + H +I Sbjct: 348 PAERADLKQLMVHAFI 363 >4WUA-A nrPDB Length = 401 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 89/385 (23%), Positives = 156/385 (40%), Gaps = 86/385 (22%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 ++ V++GD RY ++ +G G V ++D + VA+K + + + + Sbjct: 30 YHLVKIGD---LFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSA---EHYTET 83 Query: 108 AYRELVLMKCV--------NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM 159 A E+ L+K V N + ++ LL+ F + +V E++ +L + I + Sbjct: 84 ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWI-I 140 Query: 160 ELDHERMSY-----LLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKSD------------- 200 + +++ + ++ Q+L G+ +LH+ IIH D+KP NI++ + Sbjct: 141 KSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATE 200 Query: 201 ------------------------------------CTLKILDFGLARTAGTSFMMTPYV 224 +KI D G A F T + Sbjct: 201 WQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHF--TEDI 258 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF---PGRDYI---DQWNKVIEQ 278 TR YR+ EV++G GY DIWS C+ E+ LF G +Y D +IE Sbjct: 259 QTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIEL 318 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA---DSEHNKLKASQARDL 335 LG P + + + + +T KL P LF E ++ +A+ D Sbjct: 319 LGK-VPRKLIVAGKYSKEFFTKKGDLKHIT--KLKPWGLFEVLVEKYEWSQEEAAGFTDF 375 Query: 336 LSKMLVIDPAKRISVDDALQHPYIN 360 L ML + P KR + + L+HP++N Sbjct: 376 LLPMLELIPEKRATAAECLRHPWLN 400 >3FME-A nrPDB Length = 290 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 70/273 (25%), Positives = 118/273 (43%), Gaps = 41/273 (15%) Query: 63 RYQNLKPI---GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCV 118 + +L+PI G GA G+V + +A+K++ R N KR +L + M+ V Sbjct: 5 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTV 63 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD------HERMSYLLYQ 172 + ++ + DV++ MELMD +L + + +D + + + Sbjct: 64 DCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 117 Query: 173 MLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ + Y A Sbjct: 118 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMA 177 Query: 232 PEVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT----PC 283 PE I GY DIWS+G M E+ + FP D W +QL P Sbjct: 178 PERINPELNQKGYSVKSDIWSLGITMIELAILR--FP----YDSWGTPFQQLKQVVEEPS 231 Query: 284 P---------EFMKKLQPTVRNYVENRPKYAGL 307 P EF+ ++ + RP Y L Sbjct: 232 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 264 >2ZMD-A nrPDB Length = 390 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 103/243 (42%), Gaps = 58/243 (23%) Query: 140 QDVYLVMELMDANLCQVIQMELD---HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 Q +Y+VME + +L ++ + ER SY ML + +H GI+H DLKP+N + Sbjct: 129 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 187 Query: 197 VKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVILGM-GYKEN--------- 243 + D LK++DFG+A TS + V Y PE I M +EN Sbjct: 188 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISP 246 Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 D+WS+GCI+ M K F ++I Q+ KL + P Sbjct: 247 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAII------DP 283 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + + FP + L +D+L L DP +RIS+ + L HPY+ + Sbjct: 284 NHE-IEFPDIPEKDL---------------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 327 Query: 363 YDP 365 P Sbjct: 328 THP 330 >5A46-A nrPDB Length = 386 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 25/213 (11%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 KP+G G G V A LD++ VA+K L + + E+ +MK + Sbjct: 46 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGK 104 Query: 120 HKNIISLLNVFT---PQKTLEEFQDVYLVMELMDA----------NLCQVIQMELDHERM 166 HKNII+LL T P + E+ + E + A N + +L + + Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 165 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 224 Query: 227 RY---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 R + APE + Y D+WS G ++ E+ Sbjct: 225 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 257 >4XCU-A nrPDB Length = 300 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 94/214 (43%), Gaps = 36/214 (16%) Query: 68 KPIGSGAQGIVCAAYDAVLD-------RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 KP+G G G V A +D VA+K L ++ A E+ +MK + Sbjct: 23 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD-LVSEMEVMKLIGR 81 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME---------LDHERMSYL 169 HKNII+LL V T + L Y+++E NL + ++ L + Sbjct: 82 HKNIINLLGVCTQEGPL------YVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSC 135 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-------GTSFMMTP 222 YQ+ G+++L S IHRDL N++V D +KI DFGLAR TS P Sbjct: 136 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195 Query: 223 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM 256 + APE + Y D+WS G ++ E+ Sbjct: 196 V----KWMAPEALFDRVYTHQSDVWSFGILLWEI 225 >5AP3-A nrPDB Length = 313 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 104/244 (42%), Gaps = 58/244 (23%) Query: 140 QDVYLVMELMDANLCQVIQMELD---HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 Q +Y+VME + +L ++ + ER SY ML + +H GI+H DLKP+N + Sbjct: 101 QYIYMVMECGNIDLNGWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPANFL 159 Query: 197 VKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVILGM-GYKEN--------- 243 + D LK++DFG+A TS + V T Y PE I M +EN Sbjct: 160 I-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 218 Query: 244 -VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 D+WS+GCI+ M K F ++I Q+ KL + P Sbjct: 219 KSDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAII------DP 255 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW 362 + + FP + L +D+L L DP +RIS+ + L HPY+ + Sbjct: 256 NHE-IEFPDIPEKDL---------------QDVLKCCLKRDPKQRISIPELLAHPYVQIQ 299 Query: 363 YDPA 366 P Sbjct: 300 THPV 303 >3A8W-A nrPDB Length = 345 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 22/208 (10%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR--ELVLMKCV 118 L+ + L+ IG G+ V DR A+K + + N + + V + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQMELDHERMSYLLYQMLC 175 NH ++ L + F + L + V+E ++ Q +L E + ++ Sbjct: 68 NHPFLVGLHSCFQTESRL------FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL 121 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA------GTSFMMTPYVVTRYY 229 + +LH GII+RDLK N+++ S+ +K+ D+G+ + ++F TP Y Sbjct: 122 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP-----NY 176 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMV 257 APE++ G Y +VD W++G +M EM+ Sbjct: 177 IAPEILRGEDYGFSVDWWALGVLMFEMM 204 >5HI2-A nrPDB Length = 283 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 139/305 (45%), Gaps = 60/305 (19%) Query: 36 HYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL 95 H++ S+ D+ E+ D TV +R IGSG+ G V Y +VA+K L Sbjct: 4 HHHGSRDSSDDW----EIPDGQITVGQR------IGSGSFGTV---YKGKWHGDVAVKML 50 Query: 96 SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFT-PQKTLEEFQDVYLVMELMDA--- 151 + P Q Q E+ +++ H NI+ + T PQ + +V + + Sbjct: 51 T-PQQLQAFKN----EVGVLRKTRHVNILLFMGYSTKPQ--------LAIVTQWCEGSSL 97 Query: 152 -NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL 210 + + + + +++ + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGL Sbjct: 98 YHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGL 157 Query: 211 A----RTAGTSFMMTPYVVTRYYRAPEVILGMG---YKENVDIWSVGCIMGEMVRHKILF 263 A R +G S + + APEVI Y D+++ G ++ E++ ++ + Sbjct: 158 ATVKSRWSG-SHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPY 216 Query: 264 PGRDYIDQWNKVIEQLG------------TPCPEFMKKLQPT-VRNYVENRPKYAGLTFP 310 I+ +++IE +G + CP+ MK+L ++ + RP +FP Sbjct: 217 SN---INNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERP-----SFP 268 Query: 311 KLFPD 315 ++ + Sbjct: 269 RILAE 273 >4UYA-A nrPDB Length = 340 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 81/278 (29%), Positives = 118/278 (42%), Gaps = 40/278 (14%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD-RNVAIKKLSR-PFQNQTHAKRAYR- 110 G +R + + IG+G G V Y A + VA+K + P Q+ A + R Sbjct: 18 GSPVHVAFERLELKELIGAGGFGQV---YRATWQGQEVAVKAARQDPEQDAAAAAESVRR 74 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER----- 165 E L + H NII L V Q L LV+E + L R Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHL------CLVLEFARGG---ALNRALAGRRIPPHV 125 Query: 166 MSYLLYQMLCGIKHLHSAG---IIHRDLKPSNIVVKSDC--------TLKILDFGLARTA 214 + Q+ G+ +LH I+HRDLK SNI++ TLKI DFGLAR Sbjct: 126 LVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW 185 Query: 215 G-TSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-----Y 268 T+ M T + APEVI + + DIWS G ++ E++ ++ + G D Y Sbjct: 186 HRTTKMATAGAYA--WMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAY 243 Query: 269 IDQWNKVIEQLGTPCPE-FMKKLQPTVRNYVENRPKYA 305 NK+ + + CPE F K ++ + RP +A Sbjct: 244 GVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFA 281 >4AN9-A nrPDB Length = 301 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 71/304 (23%), Positives = 128/304 (42%), Gaps = 60/304 (19%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++ + +G+G G+V V+ R + ++ +NQ REL ++ N Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 65 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCG 176 I+ F ++ + ME MD +L QV++ + + + + ++ G Sbjct: 66 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 119 Query: 177 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + +L I+HRD+KPSNI+V S +K+ DFG++ M +V TR Y +PE + Sbjct: 120 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL-IDEMANEFVGTRSYMSPERL 178 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y DIWS+G + EM + P P F + Sbjct: 179 QGTHYSVQSDIWSMGLSLVEMAVGRYPRP-----------------PMAIF------ELL 215 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 +Y+ N P P P ++F + + +D ++K L+ +PA+R + + Sbjct: 216 DYIVNEP-------PPKLPSAVF----------SLEFQDFVNKCLIKNPAERADLKQLMV 258 Query: 356 HPYI 359 H +I Sbjct: 259 HAFI 262 >2FO0-A nrPDB Length = 495 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/264 (23%), Positives = 120/264 (45%), Gaps = 28/264 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G V VA+K L ++ + +E +MK + H N++ LL V Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 281 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAG 184 T + Y++ E M NL ++ E++ + Y+ Q+ +++L Sbjct: 282 CTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN 335 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGYK 241 IHR+L N +V + +K+ DFGL+R T T + ++ + APE + + Sbjct: 336 FIHRNLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNKFS 394 Query: 242 ENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQPTVR 295 D+W+ G ++ E+ + + +PG D + Q +++E ++ P CPE + +L Sbjct: 395 IKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACW 453 Query: 296 NYV-ENRPKYAGL--TFPKLFPDS 316 + +RP +A + F +F +S Sbjct: 454 QWNPSDRPSFAEIHQAFETMFQES 477 >3EQC-A nrPDB Length = 360 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 98/212 (46%), Gaps = 20/212 (9%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++ + +G+G G+V V+ R + ++ +NQ REL ++ N Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI-----IRELQVLHECN 89 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLCG 176 I+ F ++ + ME MD +L QV++ + + + + ++ G Sbjct: 90 SPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 143 Query: 177 IKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + +L I+HRD+KPSNI+V S +K+ DFG++ S M +V TR Y +PE + Sbjct: 144 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS-MANSFVGTRSYMSPERL 202 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRD 267 G Y DIWS+G + EM + P D Sbjct: 203 QGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPD 234 >4FZF-B nrPDB Length = 283 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 10/198 (5%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ IG G+ G V D + VAIK + VL +C + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSSYV 68 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLCGIKHLH 181 + L +++ME + L + D +++ +L ++L G+ +LH Sbjct: 69 TKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLH 122 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 S IHRD+K +N+++ +K+ FG+A + T +V T ++ APEVI Y Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 182 Query: 241 KENVDIWSVGCIMGEMVR 258 DIWS+G E+ + Sbjct: 183 DSKADIWSLGITAIELAK 200 >5HIE-A nrPDB Length = 302 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 121/269 (44%), Gaps = 62/269 (23%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 E+ D TV +R IGSG+ G V Y +VA+K L+ P Q Q E Sbjct: 32 EIPDGQITVGQR------IGSGSFGTV---YKGKWHGDVAVKMLT-PQQLQAFKN----E 77 Query: 112 LVLMKCVNHKNIISLLNVFT-PQKTLE----EFQDVYLVMELMDANLCQVIQMELDHERM 166 + +++ H NI+ + T PQ + E +Y + +I+ + + ++ Sbjct: 78 VGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLY--------HHLHIIETKFEMIKL 129 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-------------RT 213 + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA + Sbjct: 130 IDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL 189 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV-----------RHKIL 262 +G+ M P V+ + P Y D+++ G ++ E++ R +I+ Sbjct: 190 SGSILWMAPEVIRMQDKNP-------YSFQSDVYAFGIVLYELMTGQLPYSNINNRDQII 242 Query: 263 F-PGRDYIDQWNKVIEQLGTPCPEFMKKL 290 F GR Y+ + + ++ + CP+ MK+L Sbjct: 243 FMVGRGYL---SPDLSKVRSNCPKAMKRL 268 >2XIK-A nrPDB Length = 294 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 86/198 (43%), Gaps = 10/198 (5%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L IG G+ G V D VAIK + VL +C + I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYI 79 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLCGIKHLH 181 + L +++ME + L + L+ ++ +L ++L G+ +LH Sbjct: 80 TRYFGSYLKSTKL------WIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLH 133 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 S IHRD+K +N+++ +K+ DFG+A + T +V T ++ APEVI Y Sbjct: 134 SERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 193 Query: 241 KENVDIWSVGCIMGEMVR 258 DIWS+G E+ + Sbjct: 194 DFKADIWSLGITAIELAK 211 >1JPA-A nrPDB Length = 312 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 116/274 (42%), Gaps = 36/274 (13%) Query: 70 IGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 IG+G G VC+ + + + VAIK L + + + E +M +H N+I L Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQRRDFLSEASIMGQFDHPNVIHL 99 Query: 127 LNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 V T P + EF + + + N Q ++L +L + G+K+L Sbjct: 100 EGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQL-----VGMLRGIAAGMKYLADM 154 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV------VTRYYRAPEVILG 237 +HRDL NI+V S+ K+ DFGL+R Y + + APE I Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK----VIEQ---LGTP--CPEFMK 288 + D+WS G +M E++ + R Y D N+ IEQ L P CP + Sbjct: 215 RKFTSASDVWSYGIVMWEVMS----YGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALH 270 Query: 289 KLQPTVRNYVEN-RPKYAGL--TFPKLF--PDSL 317 +L N RPK+ + T K+ P+SL Sbjct: 271 QLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSL 304 >3LLT-A nrPDB Length = 360 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 102/221 (46%), Gaps = 39/221 (17%) Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV------KSDCTLKILDFG----LARTAGTSFMMT 221 ++L + +L + H DLKP NI++ KS T++ + G + RT T + Sbjct: 145 EILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLI 204 Query: 222 PY-------------VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDY 268 + + TR YRAPEVIL +G+ + D+WS GC++ E+ +LF ++ Sbjct: 205 DFGCATFKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEH 264 Query: 269 IDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKL-FPDSLFPADS-EHNK 326 ++ ++E + P P+ M L + N KY KL +P++ +S +H K Sbjct: 265 MEHL-AMMESIIQPIPKNM--LYEATKT---NGSKYVNKDELKLAWPENASSINSIKHVK 318 Query: 327 --------LKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 +K D L +L IDP R S + L+H ++ Sbjct: 319 KCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >3DTC-A nrPDB Length = 271 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 73/247 (29%), Positives = 109/247 (44%), Gaps = 29/247 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR-ELVLMKCVNHKNIISLL 127 IG G G V A+ + VA+K P ++ + R E L + H NII+L Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGI 185 V + L LVME L +V+ + + + + Q+ G+ +LH I Sbjct: 73 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 186 ---IHRDLKPSNIVVK--------SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV 234 IHRDLK SNI++ S+ LKI DFGLAR + M+ + APEV Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWMAPEV 185 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-----YIDQWNKVIEQLGTPCPEFMKK 289 I + + D+WS G ++ E++ ++ F G D Y NK+ + + CPE K Sbjct: 186 IRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAK 245 Query: 290 LQPTVRN 296 L N Sbjct: 246 LMEDCWN 252 >2XYN-A nrPDB Length = 292 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 63/265 (23%), Positives = 118/265 (44%), Gaps = 30/265 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G V VA+K L ++ + +E +MK + H N++ LL V Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 96 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMS-----YLLYQMLCGIKHLHSA 183 T + Y+V E M NL ++ E + E ++ Y+ Q+ +++L Sbjct: 97 CTLEPPF------YIVTEYMPYGNLLDYLR-ECNREEVTAVVLLYMATQISSAMEYLEKK 149 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGY 240 IHRDL N +V + +K+ DFGL+R T T + ++ + APE + + Sbjct: 150 NFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNTF 208 Query: 241 KENVDIWSVGCIMGEMVRHKIL-FPG------RDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 D+W+ G ++ E+ + + +PG D +++ ++ + G P P+ + ++ Sbjct: 209 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP-PKVYELMRAC 267 Query: 294 VRNYVENRPKYAGL--TFPKLFPDS 316 + +RP +A F +F DS Sbjct: 268 WKWSPADRPSFAETHQAFETMFHDS 292 >2PL0-A nrPDB Length = 289 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 103/229 (44%), Gaps = 39/229 (17%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 EV T +++R +G+G G V Y + VA+K L Q E Sbjct: 19 EVPRETLKLVER------LGAGQFGEVWMGYYNGHTK-VAVKSLK---QGSMSPDAFLAE 68 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERM 166 LMK + H+ ++ L V T + +Y++ E M+ +L ++ ++L ++ Sbjct: 69 ANLMKQLQHQRLVRLYAVVTQEP-------IYIITEYMENGSLVDFLKTPSGIKLTINKL 121 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-------TA--GTS 217 + Q+ G+ + IHRDL+ +NI+V + KI DFGLAR TA G Sbjct: 122 LDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK 181 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRH-KILFPG 265 F + + APE I + D+WS G ++ E+V H +I +PG Sbjct: 182 FPIK-------WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >3PFQ-A nrPDB Length = 674 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 75/143 (52%), Gaps = 8/143 (5%) Query: 142 VYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 +Y VME ++ ++ QV + + H + ++ G+ L S GII+RDLK N++ Sbjct: 417 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 474 Query: 197 VKSDCTLKILDFGLARTAGTSFMMTP-YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 255 + S+ +KI DFG+ + + T + T Y APE+I Y ++VD W+ G ++ E Sbjct: 475 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 534 Query: 256 MVRHKILFPGRDYIDQWNKVIEQ 278 M+ + F G D + + ++E Sbjct: 535 MLAGQAPFEGEDEDELFQSIMEH 557 >5MJB-A nrPDB Length = 305 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 100/235 (42%), Gaps = 29/235 (12%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFT---PQKTLEEFQDVYLVM 146 VAIK L + ++ + E +M +H+NII L V T P + EF + + Sbjct: 57 VAIKTLKAGY-SEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALD 115 Query: 147 ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 + N Q ++L +L + G+K+L +HRDL NI+V S+ K+ Sbjct: 116 SFLRQNDGQFTVIQLVG-----MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVS 170 Query: 207 DFGLARTAGTSFMMTPYV------VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK 260 DFGL+R Y + + APE I + D+WS G +M E++ Sbjct: 171 DFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS-- 228 Query: 261 ILFPGRDYIDQWNK----VIEQ---LGTP--CPEFMKKLQPTVRNYVEN-RPKYA 305 F R Y D N+ IEQ L P CP + +L N RP++A Sbjct: 229 --FGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFA 281 >4HVI-A nrPDB Length = 314 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 101/218 (46%), Gaps = 26/218 (11%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIV-CAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYR 110 D T + + + +G G G V YD + D VA+K+L +Q + R Sbjct: 3 DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ--RDFQR 60 Query: 111 ELVLMKCVNHKNIISLLNV-FTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHER 165 E+ ++K ++ I+ V + P + Q + LVME + + + Q + LD R Sbjct: 61 EIQILKALHSDFIVKYRGVSYGPGR-----QSLRLVMEYLPSGCLRDFLQRHRARLDASR 115 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 + Q+ G+++L S +HRDL NI+V+S+ +KI DFGLA+ + Y V Sbjct: 116 LLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLP---LDKDYYV 172 Query: 226 TR-------YYRAPEVILGMGYKENVDIWSVGCIMGEM 256 R ++ APE + + D+WS G ++ E+ Sbjct: 173 VREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL 210 >4P5Q-A nrPDB Length = 361 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 89/203 (43%), Gaps = 18/203 (8%) Query: 68 KPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 K +G+G G VC+ + + +VAIK L + + + E +M +H NII Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHPNII 97 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGI----KHL 180 L V T K V +V E M+ + D + L ML GI K+L Sbjct: 98 RLEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYL 151 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVIL 236 G +HRDL NI++ S+ K+ DFGL+R ++ + + +PE I Sbjct: 152 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA 211 Query: 237 GMGYKENVDIWSVGCIMGEMVRH 259 + D+WS G ++ E++ + Sbjct: 212 YRKFTSASDVWSYGIVLWEVMSY 234 >2W1I-A nrPDB Length = 326 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 67/270 (24%), Positives = 116/270 (42%), Gaps = 40/270 (14%) Query: 67 LKPIGSGAQGIV-CAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 L+ +G G G V YD + D VA+KKL + H + RE+ ++K + H N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKSLQHDN 103 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHERMSYLLYQMLCGIK 178 I+ V +++ L+ME + + Q + +DH ++ Q+ G++ Sbjct: 104 IVKYKGVCYSAGR----RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 159 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPEV 234 +L + IHRDL NI+V+++ +KI DFGL + + P ++ APE Sbjct: 160 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 219 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM------K 288 + + D+WS G ++ E+ + IE+ +P EFM K Sbjct: 220 LTESKFSVASDVWSFGVVLYELFTY----------------IEKSKSPPAEFMRMIGNDK 263 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLF 318 + Q V + +E L P PD ++ Sbjct: 264 QGQMIVFHLIELLKNNGRLPRPDGCPDEIY 293 >4RA4-A nrPDB Length = 355 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 43/141 (30%), Positives = 74/141 (52%), Gaps = 4/141 (2%) Query: 142 VYLVMELMDA-NLCQVIQMELDHERMSYLLY--QMLCGIKHLHSAGIIHRDLKPSNIVVK 198 +Y VME ++ +L IQ + + Y ++ G+ LH GII+RDLK N+++ Sbjct: 96 LYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD 155 Query: 199 SDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 S+ +KI DFG+ + + T + T Y APE+I Y ++VD W+ G ++ EM+ Sbjct: 156 SEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEML 215 Query: 258 RHKILFPGRDYIDQWNKVIEQ 278 + F G D + + ++E Sbjct: 216 AGQPPFDGEDEDELFQSIMEH 236 >4IDT-A nrPDB Length = 356 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 27/200 (13%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC--VNHKNIISLL 127 +G G+ G V D A+KK+ +R LM C + I+ L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRL---------EVFRAEELMACAGLTSPRIVPLY 132 Query: 128 NVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAG 184 + E V + MEL++ +L Q+++ + L +R Y L Q L G+++LHS Sbjct: 133 G------AVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRR 186 Query: 185 IIHRDLKPSNIVVKSDCTLKIL-DFGLA-----RTAGTSFMMTPYV-VTRYYRAPEVILG 237 I+H D+K N+++ SD + L DFG A G + Y+ T + APEV+LG Sbjct: 187 ILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG 246 Query: 238 MGYKENVDIWSVGCIMGEMV 257 VD+WS C+M M+ Sbjct: 247 RSCDAKVDVWSSCCMMLHML 266 >6BXI-A nrPDB Length = 333 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 98/242 (40%), Gaps = 56/242 (23%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP---FQNQTHAKRAYRELVLMKC 117 L+ +++LK IG GA G V A+K L + + Q RA R++++ Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV--- 61 Query: 118 VNHKNIISLLNVFTPQKTLEEFQD---VYLVMELMDANLCQVIQMELD---HERMSYLLY 171 SL V K FQD +YL+ME + + M+ D E + + Sbjct: 62 ----EADSLWVV----KMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIA 113 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA----RTAGTSF--------- 218 + + I +H G IHRD+KP N+++ S +K+ DFGL + T F Sbjct: 114 ETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLP 173 Query: 219 -----------------------MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 255 + V T Y APEV + GY + D WS+G IM E Sbjct: 174 SDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYE 233 Query: 256 MV 257 M+ Sbjct: 234 ML 235 >5UIU-A nrPDB Length = 323 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/231 (29%), Positives = 103/231 (44%), Gaps = 29/231 (12%) Query: 50 SVEVGDSTFTVLKRYQ--------NLKPI-------GSGAQGIVCAAYDAVLDRNVAIKK 94 S+EV D+ F Y+ + +PI G G G+V Y V + VA+KK Sbjct: 20 SLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGY--VNNTTVAVKK 77 Query: 95 LSRPFQNQTHA-KRAY-RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM---ELM 149 L+ T K+ + +E+ +M H+N++ LL + ++ VY+ M L+ Sbjct: 78 LAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDG---DDLCLVYVYMPNGSLL 134 Query: 150 DANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG 209 D C L + GI LH IHRD+K +NI++ T KI DFG Sbjct: 135 DRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFG 194 Query: 210 LARTA---GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 LAR + + M + V T Y APE + G DI+S G ++ E++ Sbjct: 195 LARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLLEII 244 >3A4O-X nrPDB Length = 286 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 111/259 (42%), Gaps = 39/259 (15%) Query: 67 LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIIS 125 +K +G+G G V Y N + K + + T + +A+ E LMK + H ++ Sbjct: 18 VKRLGAGQFGEVWMGY-----YNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 72 Query: 126 LLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHE----RMSYLLYQMLCGIKHL 180 L V T + + +Y++ E M +L ++ + + ++ Q+ G+ ++ Sbjct: 73 LYAVVTRE------EPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 126 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---------AGTSFMMTPYVVTRYYRA 231 IHRDL+ +N++V KI DFGLAR G F + + A Sbjct: 127 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIK-------WTA 179 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLGTP----CP-E 285 PE I + D+WS G ++ E+V + KI +PGR D + + P CP E Sbjct: 180 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 239 Query: 286 FMKKLQPTVRNYVENRPKY 304 ++ + E RP + Sbjct: 240 LYDIMKMCWKEKAEERPTF 258 >1TKI-A nrPDB Length = 321 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/306 (22%), Positives = 131/306 (42%), Gaps = 57/306 (18%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++Y + +G G GIV + + K + +Q K+ E+ ++ H+ Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIARHR 61 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ---MELDHERMSYLLYQMLCGI 177 NI+ L ++ E +++ ++ E + ++ + I EL+ + ++Q+ + Sbjct: 62 NILHL------HESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEAL 115 Query: 178 KHLHSAGIIHRDLKPSNIV--VKSDCTLKILDFGLARTA--GTSFMMTPYVVTRYYRAPE 233 + LHS I H D++P NI+ + T+KI++FG AR G +F + + YY APE Sbjct: 116 QFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLL-FTAPEYY-APE 173 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V D+WS+G ++ +L G + P + Q Sbjct: 174 VHQHDVVSTATDMWSLGTLV------YVLLSGIN----------------PFLAETNQQI 211 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 + N + A TF D E K + +A D + ++LV + R++ +A Sbjct: 212 IENIMN-----AEYTF-----------DEEAFKEISIEAMDFVDRLLVKERKSRMTASEA 255 Query: 354 LQHPYI 359 LQHP++ Sbjct: 256 LQHPWL 261 >3IO7-A nrPDB Length = 313 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/270 (24%), Positives = 116/270 (42%), Gaps = 40/270 (14%) Query: 67 LKPIGSGAQGIV-CAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 L+ +G G G V YD + D VA+KKL + H + RE+ ++K + H N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKSLQHDN 90 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHERMSYLLYQMLCGIK 178 I+ V +++ L+ME + + Q + +DH ++ Q+ G++ Sbjct: 91 IVKYKGVCYSAGR----RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 146 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPEV 234 +L + IHRDL NI+V+++ +KI DFGL + + P ++ APE Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 206 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM------K 288 + + D+WS G ++ E+ + IE+ +P EFM K Sbjct: 207 LTESKFSVASDVWSFGVVLYELFTY----------------IEKSKSPPAEFMRMIGNDK 250 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLF 318 + Q V + +E L P PD ++ Sbjct: 251 QGQMIVFHLIELLKNNGRLPRPDGCPDEIY 280 >3TXO-A nrPDB Length = 353 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 97/215 (45%), Gaps = 14/215 (6%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKR 107 + V S + ++ ++ +G G+ G V A A+K L + Q+ Sbjct: 11 GIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECT 70 Query: 108 AYRELVLMKCVNHKNIISLLNVF-TPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDH 163 + +L NH + L F TP + ++ VME ++ +L IQ D Sbjct: 71 MTEKRILSLARNHPFLTQLFCCFQTPDR-------LFFVMEFVNGGDLMFHIQKSRRFDE 123 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP- 222 R + +++ + LH GII+RDLK N+++ + K+ DFG+ + + + T Sbjct: 124 ARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTAT 183 Query: 223 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 + T Y APE++ M Y VD W++G ++ EM+ Sbjct: 184 FCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEML 218 >4EBW-A nrPDB Length = 304 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 72/284 (25%), Positives = 123/284 (43%), Gaps = 30/284 (10%) Query: 44 VDNQFYSVEVGDST--FTVLK-RYQNLKPIGSGA-----QGIVCAAYDAVLDRNVAIKKL 95 +N ++ +G ST + + + R + + IG G QGI + + L VAIK Sbjct: 17 TENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAL--AVAIKTC 74 Query: 96 SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----A 151 + K +E + M+ +H +I+ L+ V T V+++MEL Sbjct: 75 KNCTSDSVREK-FLQEALTMRQFDHPHIVKLIGVITENP-------VWIIMELCTLGELR 126 Query: 152 NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA 211 + QV + LD + YQ+ + +L S +HRD+ N++V S+ +K+ DFGL+ Sbjct: 127 SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLS 186 Query: 212 RTA--GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIL-FPGRDY 268 R T + + + + APE I + D+W G M E++ H + F G Sbjct: 187 RYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKN 246 Query: 269 IDQWNKV--IEQLGTP--CPEFMKKLQPTVRNY-VENRPKYAGL 307 D ++ E+L P CP + L Y RP++ L Sbjct: 247 NDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTEL 290 >2I0E-A nrPDB Length = 353 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 42/143 (29%), Positives = 75/143 (52%), Gaps = 8/143 (5%) Query: 142 VYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 +Y VME ++ ++ QV + + H + ++ G+ L S GII+RDLK N++ Sbjct: 96 LYFVMEYVNGGDLMYHIQQVGRFKEPH--AVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 153 Query: 197 VKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 255 + S+ +KI DFG+ + + T + T Y APE+I Y ++VD W+ G ++ E Sbjct: 154 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 213 Query: 256 MVRHKILFPGRDYIDQWNKVIEQ 278 M+ + F G D + + ++E Sbjct: 214 MLAGQAPFEGEDEDELFQSIMEH 236 >2H8H-A nrPDB Length = 535 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 108/236 (45%), Gaps = 39/236 (16%) Query: 90 VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 VAIK L + T + A+ +E +MK + H+ ++ L V + + +Y+V E Sbjct: 294 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEY 342 Query: 149 MD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 M +L ++ E L ++ + Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 343 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 402 Query: 204 KILDFGLAR-------TA--GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMG 254 K+ DFGLAR TA G F + + APE L + D+WS G ++ Sbjct: 403 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 455 Query: 255 EM-VRHKILFPG---RDYIDQWNKVIEQLGTP-CPEFMKKLQ-PTVRNYVENRPKY 304 E+ + ++ +PG R+ +DQ + P CPE + L R E RP + Sbjct: 456 ELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 511 >5KCV-A nrPDB Length = 460 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 76/327 (23%), Positives = 128/327 (39%), Gaps = 61/327 (18%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 118 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 160 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 219 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 175 H + +L F L VME + L + E +R + +++ Sbjct: 220 RHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 273 Query: 176 GIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 233 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y APE Sbjct: 274 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 333 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y VD W +G +M EM+ ++ F +D+ K+ E + L Sbjct: 334 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELI----------LMEE 379 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS---- 349 +R FP +L P +A+ LLS +L DP +R+ Sbjct: 380 IR-----------------FPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGSE 411 Query: 350 -VDDALQHPYIN--VWYDPAEVEAPPP 373 + +QH + VW E + PP Sbjct: 412 DAKEIMQHRFFAGIVWQHVYEKKLSPP 438 >4AW2-A nrPDB Length = 437 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 100/223 (44%), Gaps = 14/223 (6%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR---PFQNQTHAKRAYRELVLMKCVNH 120 ++ LK IG GA G V D+ A+K L++ + +T R R++++ + Sbjct: 76 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG--DS 133 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 K I +L F L D Y+ +L+ L + L E + L +M+ I + Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLL--TLLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFG--LARTAGTSFMMTPYVVTRYYRAPEVILGM 238 H +HRD+KP NI++ + +++ DFG L + + V T Y +PE++ M Sbjct: 192 HQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 239 -----GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 Y D WS+G M EM+ + F ++ + K++ Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 294 >4E93-A nrPDB Length = 377 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 107/262 (40%), Gaps = 51/262 (19%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G G V + + VA+K AK +E ++K +H NI+ L+ V Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGV 180 Query: 130 FTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDHERMSYLLYQML----CGIKHLHSAG 184 T + Q +Y+VMEL+ + ++ E R+ LL QM+ G+++L S Sbjct: 181 CTQK------QPIYIVMELVQGGDFLTFLRTEGARLRVKTLL-QMVGDAAAGMEYLESKC 233 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLAR-------TAGTSFMMTPYVVTRYYRAPEVILG 237 IHRDL N +V LKI DFG++R A P T APE + Sbjct: 234 CIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWT----APEALNY 289 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG-TPCPEFMKKLQPTVRN 296 Y D+WS G ++ E LG +P P + R Sbjct: 290 GRYSSESDVWSFGILLWETF--------------------SLGASPYPNLSNQ---QTRE 326 Query: 297 YVENRPKYAGLTFPKLFPDSLF 318 +VE K L P+L PD++F Sbjct: 327 FVE---KGGRLPCPELCPDAVF 345 >3MV5-A nrPDB Length = 342 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 76/327 (23%), Positives = 128/327 (39%), Gaps = 61/327 (18%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 118 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 8 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS 67 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 175 H + +L F L VME + L + E +R + +++ Sbjct: 68 RHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVS 121 Query: 176 GIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 233 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y APE Sbjct: 122 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 181 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y VD W +G +M EM+ ++ F +D+ K+ E + L Sbjct: 182 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELI----------LMEE 227 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS---- 349 +R FP +L P +A+ LLS +L DP +R+ Sbjct: 228 IR-----------------FPRTLGP-----------EAKSLLSGLLKKDPKQRLGGGSE 259 Query: 350 -VDDALQHPYIN--VWYDPAEVEAPPP 373 + +QH + VW E + PP Sbjct: 260 DAKEIMQHRFFAGIVWQHVYEKKLSPP 286 >2Y6O-A nrPDB Length = 291 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 79/283 (27%), Positives = 117/283 (41%), Gaps = 36/283 (12%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 K IG G G VC+ V + VAIK L + ++ + E +M +H NII Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQR-RDFLSEASIMGQFDHPNII 78 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGI----KHL 180 L V T K V ++ E M+ + D L ML GI K+L Sbjct: 79 HLEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYL 132 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVIL 236 +HRDL NI+V S+ K+ DFG++R ++ + + APE I Sbjct: 133 SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN----KVIEQ---LGTP--CPEFM 287 + D+WS G +M E++ + R Y D N K IE+ L P CP + Sbjct: 193 YRKFTSASDVWSYGIVMWEVMS----YGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIAL 248 Query: 288 KKLQ-PTVRNYVENRPKYAGLT--FPKLF--PDSLFPADSEHN 325 +L + +RPK+ + KL P+SL SE + Sbjct: 249 HQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESS 291 >5L6P-A nrPDB Length = 298 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 85/202 (42%), Gaps = 18/202 (8%) Query: 70 IGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 IG+G G VC R VAIK L + + + E +M +H NII L Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQFDHPNIIRL 85 Query: 127 LNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 V T P L EF + + + N Q ++L +L + G+K+L Sbjct: 86 EGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQL-----VGMLRGIAAGMKYLSEM 140 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV------VTRYYRAPEVILG 237 +HRDL NI+V S+ K+ DFGL+R Y + + APE I Sbjct: 141 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAY 200 Query: 238 MGYKENVDIWSVGCIMGEMVRH 259 + D+WS G +M E++ + Sbjct: 201 RKFTSASDVWSYGIVMWEVMSY 222 >4G3E-A nrPDB Length = 352 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 47/126 (37%), Positives = 70/126 (55%), Gaps = 10/126 (7%) Query: 142 VYLVMELMDA-NLCQVI-QME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 198 V + MEL++ +L Q+I QM L +R Y L Q L G+++LH+ I+H D+K N+++ Sbjct: 141 VNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLS 200 Query: 199 SDCTLKIL-DFGLA-----RTAGTSFMMTPYV-VTRYYRAPEVILGMGYKENVDIWSVGC 251 SD + L DFG A G S + Y+ T + APEV++G VDIWS C Sbjct: 201 SDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCC 260 Query: 252 IMGEMV 257 +M M+ Sbjct: 261 MMLHML 266 >3OMV-A nrPDB Length = 307 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 74/262 (28%), Positives = 119/262 (45%), Gaps = 44/262 (16%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIK--KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 IGSG+ G V Y +VA+K K+ P Q A R E+ +++ H NI+ + Sbjct: 44 IGSGSFGTV---YKGKWHGDVAVKILKVVDPTPEQFQAFR--NEVAVLRKTRHVNILLFM 98 Query: 128 NVFTPQKTLE-----EFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 T E +Y + + + Q+ Q+ +D R Q G+ +LH+ Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHLHVQETKF-QMFQL-IDIAR------QTAQGMDYLHA 150 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLA----RTAGTSFMMTPYVVTRYYRAPEVILGM 238 IIHRD+K +NI + T+KI DFGLA R +G+ + P + + APEVI Sbjct: 151 KNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQP-TGSVLWMAPEVIRMQ 209 Query: 239 G---YKENVDIWSVGCIMGEMV-----------RHKILF-PGRDYIDQWNKVIEQLGTPC 283 + D++S G ++ E++ R +I+F GR Y + + +L C Sbjct: 210 DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYA---SPDLSKLYKNC 266 Query: 284 PEFMKKL-QPTVRNYVENRPKY 304 P+ MK+L V+ E RP + Sbjct: 267 PKAMKRLVADCVKKVKEERPLF 288 >5B2L-A nrPDB Length = 324 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 29/226 (12%) Query: 44 VDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103 + Q Y E+ D +NL +GSG G V +A+K++ R N+ Sbjct: 7 IGGQRYQAEIND--------LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GNKE 57 Query: 104 HAKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQM 159 KR +L V++K + I+ F DV++ MELM + L + +Q Sbjct: 58 ENKRILMDLDVVLKSHDCPYIVQCFGTFITN------TDVFIAMELMGTSAEKLKKRMQG 111 Query: 160 ELDHE---RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 216 + +M+ + + L +K H G+IHRD+KPSNI++ +K+ DFG++ Sbjct: 112 PIPERILGKMTVAIVKALYYLKEKH--GVIHRDVKPSNILLDERGQIKLCDFGISGRLVD 169 Query: 217 SFMMTPYVVTRYYRAPEVI-----LGMGYKENVDIWSVGCIMGEMV 257 S T Y APE I Y D+WS+G + E+ Sbjct: 170 SKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELA 215 >4CSV-A nrPDB Length = 275 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 113/262 (43%), Gaps = 44/262 (16%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +GSG G V + VA+K L + + +E +MK + H N++ L Sbjct: 17 RKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIMKKLKHPNLVQLY 73 Query: 128 NVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHLHS 182 V T + +Y++ E M +L ++ ++ + + + Q+ G+ +L S Sbjct: 74 GVCTKEPP------IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLES 127 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVVTRYYRAPE 233 IHRDL N +V + +K+ DFGLAR AG F + + APE Sbjct: 128 QNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIK-------WTAPE 180 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLG--------TPCP 284 I + D+W+ G ++ E+ + ++ +PG ++VIEQ+ CP Sbjct: 181 AISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSG----SEVIEQVERGYRMPRPQGCP 236 Query: 285 EFMKKLQPTVRNYV-ENRPKYA 305 E + +L N E RP +A Sbjct: 237 EEIYELMLQCWNKSPEERPTFA 258 >6F3F-A nrPDB Length = 455 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 110/236 (46%), Gaps = 39/236 (16%) Query: 90 VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 VAIK L + T + A+ +E +MK + H+ ++ L V + + +Y+V E Sbjct: 214 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEY 262 Query: 149 MD-ANLCQVIQMELD-HERMSYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 M+ +L ++ E + R+ L+ Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 263 MNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVC 322 Query: 204 KILDFGLAR-------TA--GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMG 254 K+ DFGLAR TA G F + + APE L + D+WS G ++ Sbjct: 323 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 375 Query: 255 EM-VRHKILFPG---RDYIDQWNKVIEQLGTP-CPEFMKKLQ-PTVRNYVENRPKY 304 E+ + ++ +PG R+ +DQ + P CPE + L R E RP + Sbjct: 376 ELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 431 >4TPT-A nrPDB Length = 303 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 90/212 (42%), Gaps = 32/212 (15%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G + + +K+L R ++ K E+ +M+ ++H N++ + V Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIR--CDEETQKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQMELD---HERMSYLLYQMLCGIKHLHSAGII 186 K L L+ E ++ + +D ++ + G+ +LHS II Sbjct: 66 LYKDKKLN------LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCII 119 Query: 187 HRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP-------------------YVVTR 227 HRDL N ++K D T+ + DFGL+R P Y V Sbjct: 120 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 179 Query: 228 --YYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 Y+ APE++ G Y E VDI+S G ++ E++ Sbjct: 180 NPYWMAPEMLNGKSYDETVDIFSFGIVLCEII 211 >4C59-A nrPDB Length = 340 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 63/233 (27%), Positives = 105/233 (45%), Gaps = 40/233 (17%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 +VE+G+ V + + G V A D R A+K+L N+ RA Sbjct: 21 TVELGELRLRVRR------VLAEGGFAFVYEAQDVGSGREYALKRL---LSNEEEKNRAI 71 Query: 110 -RELVLMKCVN-HKNIISLLNVFTPQKTLEEF--QDVYLVMELMDANLCQVIQ-ME---- 160 +E+ MK ++ H NI+ + + K + + L+ EL L + ++ ME Sbjct: 72 IQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP 131 Query: 161 LDHERMSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLART----- 213 L + + + YQ ++H+H IIHRDLK N+++ + T+K+ DFG A T Sbjct: 132 LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYP 191 Query: 214 ----AGTSFMMTPYVVTR----YYRAPEVI-----LGMGYKENVDIWSVGCIM 253 + + +TR YR PE+I +G K+ DIW++GCI+ Sbjct: 192 DYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQ--DIWALGCIL 242 >2VWV-A nrPDB Length = 302 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 89/217 (41%), Gaps = 22/217 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 IG+G G VC + VAIK L + + + E +M H NII L Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-TERQRREFLSEASIMGQFEHPNIIRL 82 Query: 127 LNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 V T P L EF + + + N Q ++L +L + G+++L Sbjct: 83 EGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQL-----VGMLRGIASGMRYLAEM 137 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLAR------TAGTSFMMTPYVVTRYYRAPEVILG 237 +HRDL NI+V S+ K+ DFGL+R + T + + APE I Sbjct: 138 SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAF 197 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK 274 + D WS G +M E++ F R Y D N+ Sbjct: 198 RKFTSASDAWSYGIVMWEVMS----FGERPYWDMSNQ 230 >2J0K-A nrPDB Length = 656 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 74/158 (46%), Gaps = 13/158 (8%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHER 165 +E + M+ +H +I+ L+ V T V+++MEL + QV + LD Sbjct: 440 QEALTMRQFDHPHIVKLIGVITENP-------VWIIMELCTLGELRSFLQVRKFSLDLAS 492 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPY 223 + YQ+ + +L S +HRD+ N++V + +K+ DFGL+R T + + Sbjct: 493 LILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKG 552 Query: 224 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKI 261 + + APE I + D+W G M E++ H + Sbjct: 553 KLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGV 590 >2DQ7-X nrPDB Length = 283 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 108/240 (45%), Gaps = 41/240 (17%) Query: 65 QNLKPIGSGAQG-IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKN 122 Q +K +G+G G + ++ + VAIK L + T + ++ E +MK + H Sbjct: 12 QLIKRLGNGQFGEVWMGTWNG--NTKVAIKTL----KPGTMSPESFLEEAQIMKKLKHDK 65 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLL-------YQMLC 175 ++ L V + + +Y+V E M N ++ D E + L Q+ Sbjct: 66 LVQLYAVVSEEP-------IYIVTEYM--NKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 116 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-------TA--GTSFMMTPYVVT 226 G+ ++ IHRDL+ +NI+V + KI DFGLAR TA G F + Sbjct: 117 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIK----- 171 Query: 227 RYYRAPEVILGMGYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPE 285 + APE L + D+WS G ++ E+V + ++ +PG + + +V PCP+ Sbjct: 172 --WTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ 229 >1AD5-A nrPDB Length = 438 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 95/205 (46%), Gaps = 27/205 (13%) Query: 68 KPIGSGAQGIVC-AAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 K +G+G G V A Y+ VA+K + +P A A E +MK + H ++ L Sbjct: 188 KKLGAGQFGEVWMATYNK--HTKVAVKTM-KPGSMSVEAFLA--EANVMKTLQHDKLVKL 242 Query: 127 LNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHE----RMSYLLYQMLCGIKHLH 181 V T + +Y++ E M +L ++ + + ++ Q+ G+ + Sbjct: 243 HAVVTKEP-------IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK 241 IHRDL+ +NI+V + KI DFGLAR G F + + APE I + Sbjct: 296 QRNYIHRDLRAANILVSASLVCKIADFGLARV-GAKFPIK-------WTAPEAINFGSFT 347 Query: 242 ENVDIWSVGCIMGEMVRH-KILFPG 265 D+WS G ++ E+V + +I +PG Sbjct: 348 IKSDVWSFGILLMEIVTYGRIPYPG 372 >5SYS-A nrPDB Length = 286 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 110/237 (46%), Gaps = 39/237 (16%) Query: 89 NVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 147 VAIK L + T + A+ +E +MK + H+ ++ L V + + +Y+V E Sbjct: 44 RVAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTE 92 Query: 148 LMD-ANLCQVIQMELD-HERMSYLL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT 202 M +L ++ E+ + R+ L+ Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 93 YMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV 152 Query: 203 LKILDFGLAR-------TA--GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIM 253 K+ DFGLAR TA G F + + APE L + D+WS G ++ Sbjct: 153 CKVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILL 205 Query: 254 GEM-VRHKILFPG---RDYIDQWNKVIEQLGTP-CPEFMKKLQ-PTVRNYVENRPKY 304 E+ + ++ +PG R+ +DQ + P CPE + L R E RP + Sbjct: 206 TELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTF 262 >5TUR-A nrPDB Length = 404 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 118/271 (43%), Gaps = 32/271 (11%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAYRELVLMKCV 118 +YQ +GSG G V + + VAIK + + + + R E+VL+K V Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 119 NH--KNIISLLNVFTPQKTL-------EEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 + +I LL+ F + E QD++ + A L E Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSF 238 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T + TR Sbjct: 239 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRV 297 Query: 229 YRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-LGTPCPEF 286 Y PE I Y + +WS+G ++ +MV I F + I + Q + + C Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 357 Query: 287 MK---KLQPTVR---NYVENRPKYAGLTFPK 311 ++ L+P+ R ++N P + P+ Sbjct: 358 IRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 388 >4RC3-A nrPDB Length = 289 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 118/271 (43%), Gaps = 32/271 (11%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAYRELVLMKCV 118 +YQ +GSG G V + + VAIK + + + + R E+VL+K V Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 119 N--HKNIISLLNVFTPQKTL-------EEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 + +I LL+ F + E QD++ + A L E Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSF 123 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T + TR Sbjct: 124 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRV 182 Query: 229 YRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-LGTPCPEF 286 Y PE I Y + +WS+G ++ +MV I F + I + Q + + C Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 242 Query: 287 MK---KLQPTVR---NYVENRPKYAGLTFPK 311 ++ L+P+ R ++N P + P+ Sbjct: 243 IRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 273 >2RIO-A nrPDB Length = 434 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 84/326 (25%), Positives = 137/326 (42%), Gaps = 85/326 (26%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISL 126 K +G G+ G V + R VA+K++ F A E+ +L + +H N+I Sbjct: 21 KILGYGSSGTVVFQ-GSFQGRPVAVKRMLIDF-----CDIALMEIKLLTESDDHPNVIR- 73 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ----------MELDHERMSYLLYQMLCG 176 + +T + F +Y+ +EL + NL +++ ++ ++ +S LL Q+ G Sbjct: 74 ---YYCSETTDRF--LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPIS-LLRQIASG 127 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDC-----------TLKIL--DFGLART--AGTSFMMT 221 + HLHS IIHRDLKP NI+V + L+IL DFGL + +G S T Sbjct: 128 VAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRT 187 Query: 222 PY---VVTRYYRAPEVI-------LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 T +RAPE++ ++DI+S+GC+ + IL G+ Sbjct: 188 NLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVF-----YYILSKGK----- 237 Query: 272 WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQ 331 P Y G+ SL H++ ++ Sbjct: 238 -------------------HPFGDKYSRESNIIRGIF-------SLDEMKCLHDRSLIAE 271 Query: 332 ARDLLSKMLVIDPAKRISVDDALQHP 357 A DL+S+M+ DP KR + L+HP Sbjct: 272 ATDLISQMIDHDPLKRPTAMKVLRHP 297 >4PDO-A nrPDB Length = 299 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 90/207 (43%), Gaps = 25/207 (12%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 K IG+G G V Y +L + VAIK L + + E +M +H Sbjct: 40 KVIGAGEFGEV---YKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVD-FLGEAGIMGQFSH 95 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGI--- 177 NII L V + +++ + ++ E M+ E D E L ML GI Sbjct: 96 HNIIRLEGV------ISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 149 Query: 178 -KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAP 232 K+L + +HRDL NI+V S+ K+ DFGL+R ++ + + + AP Sbjct: 150 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 209 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRH 259 E I + D+WS G +M E++ + Sbjct: 210 EAISYRKFTSASDVWSFGIVMWEVMTY 236 >3BGP-A nrPDB Length = 333 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 118/271 (43%), Gaps = 32/271 (11%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAYRELVLMKCV 118 +YQ +GSG G V + + VAIK + + + + R E+VL+K V Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 119 N--HKNIISLLNVFTPQKTL-------EEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 + +I LL+ F + E QD++ + A L E Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSF 167 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T + TR Sbjct: 168 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRV 226 Query: 229 YRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-LGTPCPEF 286 Y PE I Y + +WS+G ++ +MV I F + I + Q + + C Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 286 Query: 287 MK---KLQPTVR---NYVENRPKYAGLTFPK 311 ++ L+P+ R ++N P + P+ Sbjct: 287 IRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 317 >3TKU-A nrPDB Length = 433 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 101/224 (45%), Gaps = 16/224 (7%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE----LVLMKCVN 119 ++ +K IG GA G V +R A+K L++ + +RE LV C Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC-- 149 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 179 + I +L F + L D Y+ +L+ L + +L + + + +M+ I Sbjct: 150 -QWITALHYAFQDENHLYLVMDYYVGGDLL--TLLSKFEDKLPEDMARFYIGEMVLAIDS 206 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFG--LARTAGTSFMMTPYVVTRYYRAPEVIL- 236 +H +HRD+KP N+++ + +++ DFG L + + V T Y +PE++ Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQA 266 Query: 237 ---GMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 GMG Y D WS+G M EM+ + F ++ + K++ Sbjct: 267 MEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 310 >3CJF-A nrPDB Length = 309 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 88/211 (41%), Gaps = 26/211 (12%) Query: 68 KPIGSGAQGIVCAAYDAVLD-----RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 KP+G GA G V A +D R VA+K L + H +L+ +H N Sbjct: 33 KPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLN 92 Query: 123 IISLLNVFT----PQKTLEEFQDVYLVMELMDANLCQVIQME------LDHERMSYLLYQ 172 +++LL T P + EF + + + + + + L E + +Q Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQ 152 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR----- 227 + G++ L S IHRDL NI++ +KI DFGLAR P V + Sbjct: 153 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR----DIYKDPDYVRKGDARL 208 Query: 228 --YYRAPEVILGMGYKENVDIWSVGCIMGEM 256 + APE I Y D+WS G ++ E+ Sbjct: 209 PLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 239 >1VZO-A nrPDB Length = 355 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 79/342 (23%), Positives = 147/342 (42%), Gaps = 82/342 (23%) Query: 61 LKRYQNLKPIGSGAQGIV-----CAAYDA-------VLDRNVAIKKLSRPFQNQTHAKRA 108 ++ ++ LK +G+GA G V + +D VL + ++K T R Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQK-----AKTTEHTRT 107 Query: 109 YRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQME--LDHE 164 R+ VL +++L F + L +L+++ ++ + Q E +HE Sbjct: 108 ERQ-VLEHIRQSPFLVTLHYAFQTETKL------HLILDYINGGELFTHLSQRERFTEHE 160 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTP 222 Y+ +++ ++HLH GII+RD+K NI++ S+ + + DFGL++ A + Sbjct: 161 VQIYV-GEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYD 219 Query: 223 YVVTRYYRAPEVILG--MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 + T Y AP+++ G G+ + VD WS+G +M E++ F Sbjct: 220 FCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPF----------------- 262 Query: 281 TPCPEFMKKLQPTV-RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 + K Q + R +++ P Y P + ++ A+DL+ ++ Sbjct: 263 --TVDGEKNSQAEISRRILKSEPPY---------PQEM-----------SALAKDLIQRL 300 Query: 340 LVIDPAKRIS-----VDDALQHPY---INVWYDPAEVEAPPP 373 L+ DP KR+ D+ +H + IN W D A + P P Sbjct: 301 LMKDPKKRLGCGPRDADEIKEHLFFQKIN-WDDLAAKKVPAP 341 >6GQK-A nrPDB Length = 328 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 91/213 (42%), Gaps = 27/213 (12%) Query: 68 KPIGSGAQG-IVCAAYDAVLDRNVAIK---KLSRPFQNQTHAKRAYREL-VLMKCVNHKN 122 K +G+GA G +V A ++ + A+ K+ +P + T + EL VL NH+N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHEN 106 Query: 123 IISLLNVFT---PQKTLEEF-------------QDVYLVMELMDANLCQVIQMELDHERM 166 I++LL T P + E+ +D ++ ++ +L + L E + Sbjct: 107 IVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDF---LTLEHL 163 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 YQ+ G+ L S IHRDL NI++ KI DFGLAR Sbjct: 164 LSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNA 223 Query: 227 RY---YRAPEVILGMGYKENVDIWSVGCIMGEM 256 R + APE I Y D+WS G + E+ Sbjct: 224 RLPVKWMAPESIFNSVYTFESDVWSYGIFLWEL 256 >3PLS-A nrPDB Length = 298 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 93/203 (45%), Gaps = 24/203 (11%) Query: 70 IGSGAQGIVCAA--YDAVLDR-NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 IG G G+V D +R AIK LSR + Q + RE +LM+ +NH N+++L Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVLAL 87 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLL---YQMLCGIKHLHSA 183 + + P + L L+ + +L Q I+ + + L+ Q+ G+++L Sbjct: 88 IGIMLPPEGLPHV----LLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ 143 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR---------APEV 234 +HRDL N ++ T+K+ DFGLAR + Y + +R A E Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLAR----DILDREYYSVQQHRHARLPVKWTALES 199 Query: 235 ILGMGYKENVDIWSVGCIMGEMV 257 + + D+WS G ++ E++ Sbjct: 200 LQTYRFTTKSDVWSFGVLLWELL 222 >4XI2-A nrPDB Length = 446 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 24/200 (12%) Query: 67 LKPIGSGAQGIV-CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 LK +G+G G+V + D VAIK + + E +M ++H+ ++ Sbjct: 192 LKELGTGQFGVVKYGKWRGQYD--VAIKMIR---EGSMSEDEFIEEAKVMMNLSHEKLVQ 246 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM---LC-GIKHL 180 L V T Q+ ++++ E M AN C + + E+ H + L +M +C +++L Sbjct: 247 LYGVCTKQRP------IFIITEYM-ANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 299 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----GTSFMMTPYVVTRYYRAPEVIL 236 S +HRDL N +V +K+ DFGL+R TS + + + V + PEV++ Sbjct: 300 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVR--WSPPEVLM 357 Query: 237 GMGYKENVDIWSVGCIMGEM 256 + DIW+ G +M E+ Sbjct: 358 YSKFSSKSDIWAFGVLMWEI 377 >3PVW-A nrPDB Length = 695 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 58/96 (60%), Gaps = 6/96 (6%) Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY-- 223 M + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ Sbjct: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHAS 350 Query: 224 VVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR 258 V T Y APEV+ G+ Y + D +S+GC++ +++R Sbjct: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 386 >5UUU-A nrPDB Length = 547 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 58/96 (60%), Gaps = 6/96 (6%) Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY-- 223 M + +++ G++H+H+ +++RDLKP+NI++ ++I D GLA P+ Sbjct: 303 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKK---KPHAS 359 Query: 224 VVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR 258 V T Y APEV+ G+ Y + D +S+GC++ +++R Sbjct: 360 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLR 395 >3G2F-A nrPDB Length = 336 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 69/229 (30%), Positives = 103/229 (44%), Gaps = 38/229 (16%) Query: 67 LKPIGSGAQGIVCAAYDAVLD-RNVAIKKLS-RPFQNQTHAKRAYRELVLMKCVNHKNII 124 L+ IG G G A Y LD R VA+K S QN + K YR + + H NI Sbjct: 18 LELIGRGRYG---AVYKGSLDERPVAVKVFSFANRQNFINEKNIYR----VPLMEHDNIA 70 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMEL-DHERMSYLLYQMLCGIKHLHS 182 + V + T + + LVME + +LC+ + + D L + + G+ +LH+ Sbjct: 71 RFI-VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHT 129 Query: 183 A---------GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP---------YV 224 I HRDL N++VK+D T I DFGL+ + ++ P V Sbjct: 130 ELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEV 189 Query: 225 VTRYYRAPEVILGM-------GYKENVDIWSVGCIMGEM-VRHKILFPG 265 T Y APEV+ G + VD++++G I E+ +R LFPG Sbjct: 190 GTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 >4NEU-A nrPDB Length = 333 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 50/181 (27%), Positives = 81/181 (44%), Gaps = 35/181 (19%) Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELD 162 H + E +M + H ++ LL V + LVME M+ NL V++ E+ Sbjct: 65 HNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYS------LVMEYMEKGNLMHVLKAEMS 118 Query: 163 H--ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 ++ +++ G+ +LH G+IH+DLKP NI+V +D +KI D GLA SF M Sbjct: 119 TPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA-----SFKM 173 Query: 221 TPYV-------------------VTRYYRAPEVILGMGYK--ENVDIWSVGCIMGEMVRH 259 + T YY APE + + K E D++S ++ + + Sbjct: 174 WSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFAN 233 Query: 260 K 260 K Sbjct: 234 K 234 >4Y93-A nrPDB Length = 446 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 94/205 (45%), Gaps = 34/205 (16%) Query: 67 LKPIGSGAQGIV-CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 LK +G+G G+V + D VAIK + + E +M ++H+ ++ Sbjct: 193 LKELGTGQFGVVKYGKWRGQYD--VAIKMIK---EGSMSEDEFIEEAKVMMNLSHEKLVQ 247 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM---LC-GIKHL 180 L V T Q+ ++++ E M AN C + + E+ H + L +M +C +++L Sbjct: 248 LYGVCTKQRP------IFIITEYM-ANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 300 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVVTRYYRA 231 S +HRDL N +V +K+ DFG+ R + G+ F + + + Sbjct: 301 ESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVK-------WAS 353 Query: 232 PEVILGMGYKENVDIWSVGCIMGEM 256 PEV++ + DIW+ G +M E+ Sbjct: 354 PEVLMYSKFSSKSDIWAFGVLMWEI 378 >1FVR-A nrPDB Length = 327 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 82/203 (40%), Gaps = 15/203 (7%) Query: 70 IGSGAQGIVCAAY--DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 IG G G V A L + AIK++ H A VL K +H NII+LL Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 128 NV------------FTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDHERMSYLLYQML 174 + P L +F V+E A + L +++ + + Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV 234 G+ +L IHRDL NI+V + KI DFGL+R T + + A E Sbjct: 153 RGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIES 212 Query: 235 ILGMGYKENVDIWSVGCIMGEMV 257 + Y N D+WS G ++ E+V Sbjct: 213 LNYSVYTTNSDVWSYGVLLWEIV 235 >6E4F-A nrPDB Length = 290 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 95/200 (47%), Gaps = 24/200 (12%) Query: 67 LKPIGSGAQGIV-CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 LK +G+G G+V + D VAIK + + E +M ++H+ ++ Sbjct: 36 LKELGTGQFGVVKYGKWRGQYD--VAIKMIK---EGSMSEDEFIEEAKVMMNLSHEKLVQ 90 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM-ELDHERMSYLLYQM---LC-GIKHL 180 L V T Q+ ++++ E M AN C + + E+ H + L +M +C +++L Sbjct: 91 LYGVCTKQRP------IFIITEYM-ANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYL 143 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----GTSFMMTPYVVTRYYRAPEVIL 236 S +HRDL N +V +K+ DFGL+R TS + + + V + PEV++ Sbjct: 144 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVR--WSPPEVLM 201 Query: 237 GMGYKENVDIWSVGCIMGEM 256 + DIW+ G +M E+ Sbjct: 202 YSKFSSKSDIWAFGVLMWEI 221 >5GNK-A nrPDB Length = 297 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 94/208 (45%), Gaps = 25/208 (12%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKL---SRPFQNQTHAKRAYRELVLMK 116 ++ +K +GSGA G V + VAIK+L + P N+ AY +M Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY----VMA 76 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDHERMSYLL---YQ 172 V++ ++ LL + V L+M+LM L ++ D+ YLL Q Sbjct: 77 SVDNPHVCRLLGICLTS-------TVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 129 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT---SFMMTPYVVTRYY 229 + G+ +L ++HRDL N++VK+ +KI DFGLA+ G + V + Sbjct: 130 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 189 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMV 257 A E IL Y D+WS G + E++ Sbjct: 190 MALESILHRIYTHQSDVWSYGVTVWELM 217 >2HK5-A nrPDB Length = 270 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 96/214 (44%), Gaps = 35/214 (16%) Query: 68 KPIGSGAQGIVC-AAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 K +G+G G V A Y+ VA+K + +P A A E +MK + H ++ L Sbjct: 21 KKLGAGQFGEVWMATYNK--HTKVAVKTM-KPGSMSVEAFLA--EANVMKTLQHDKLVKL 75 Query: 127 LNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM-ELDHERMSYLL---YQMLCGIKHLH 181 V T + +Y++ E M +L ++ E + + L+ Q+ G+ + Sbjct: 76 HAVVTKE-------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLART---------AGTSFMMTPYVVTRYYRAP 232 IHRDL+ +NI+V + KI DFGLAR G F + + AP Sbjct: 129 QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIK-------WTAP 181 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRH-KILFPG 265 E I + D+WS G ++ E+V + +I +PG Sbjct: 182 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 215 >5O2C-A nrPDB Length = 380 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 10/194 (5%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V D VA +L + +R E ++K + H NI+ + Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL---LYQMLCGIKHLHSAG-- 184 + + L+ + + LV ELM + + + L Q+L G++ LH+ Sbjct: 93 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 185 IIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 IIHRDLK NI + ++KI D GLA TSF + + T + APE + Y E+ Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS-VIGTPEFMAPE-MYEEHYDES 208 Query: 244 VDIWSVGCIMGEMV 257 VD+++ G M EM Sbjct: 209 VDVYAFGMCMLEMA 222 >3G0E-A nrPDB Length = 336 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 92/217 (42%), Gaps = 33/217 (15%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-----VAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHK 121 K +G+GA G V A L ++ VA+K L +P + T + EL VL NH Sbjct: 52 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMSELKVLSYLGNHM 110 Query: 122 NIISLLNVFT---PQKTLEEF-------------QDVYLVMELMDANLCQVIQMELDHER 165 NI++LL T P + E+ +D ++ + A + + Sbjct: 111 NIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDL 170 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 +S+ YQ+ G+ L S IHRDL NI++ KI DFGLAR + YVV Sbjct: 171 LSFS-YQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND---SNYVV 226 Query: 226 TRYYR------APEVILGMGYKENVDIWSVGCIMGEM 256 R APE I Y D+WS G + E+ Sbjct: 227 KGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 263 >4PWN-A nrPDB Length = 274 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/193 (27%), Positives = 88/193 (45%), Gaps = 9/193 (4%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G+ V D VA +L ++ +R E ++K + H NI+ + Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL---LYQMLCGIKHLHSAG-- 184 + + T++ + + LV ELM + + ++ L Q+L G++ LH+ Sbjct: 78 W--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 185 IIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 IIHRDLK NI + ++KI D GLA + + T + APE + Y E+ Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE-MYEEKYDES 194 Query: 244 VDIWSVGCIMGEM 256 VD+++ G M EM Sbjct: 195 VDVYAFGMCMLEM 207 >6CTH-A nrPDB Length = 309 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/197 (26%), Positives = 90/197 (45%), Gaps = 19/197 (9%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G G V + D +A+KK+SR ++ K E+ ++ + HKN++ L+ Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRA--SKQGIKEYASEVKIISRLRHKNLVKLIG- 79 Query: 130 FTPQKTLEEFQDVYLVMELM-----DANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAG 184 E ++ LV E M D+++ + + L E ++ + + +LH G Sbjct: 80 -----WCHERGELMLVYEFMANGSLDSHIFKGKSL-LTWEVRYRIVKDLASALLYLHEEG 133 Query: 185 ---IIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTRYYRAPEVILGMG 239 ++HRD+K SNI++ S K+ DFGLAR T T Y APE + Sbjct: 134 DHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 240 YKENVDIWSVGCIMGEM 256 + D++S G + E+ Sbjct: 194 ASKESDVYSFGVVALEI 210 >3MY0-A nrPDB Length = 305 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 86/200 (43%), Gaps = 50/200 (25%) Query: 175 CGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLA--RTAGTSFM---MT 221 CG+ HLH I HRD K N++VKS+ I D GLA + G+ ++ Sbjct: 116 CGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNN 175 Query: 222 PYVVTRYYRAPEVI-------LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK 274 P V T+ Y APEV+ YK DIW+ G ++ E+ R I+ N Sbjct: 176 PRVGTKRYMAPEVLDEQIRTDCFESYKWT-DIWAFGLVLWEIARRTIV----------NG 224 Query: 275 VIEQLGTPC-------PEF--MKKL------QPTVRNYVENRPKYAGLTFPKLFPDSLFP 319 ++E P P F MKK+ PT+ N + P +GL ++ + +P Sbjct: 225 IVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLA--QMMRECWYP 282 Query: 320 ADSEHNKLKASQARDLLSKM 339 S +L A + + L K+ Sbjct: 283 NPSA--RLTALRIKKTLQKI 300 >6DBN-A nrPDB Length = 316 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 97/221 (43%), Gaps = 38/221 (17%) Query: 62 KRY-QNLKPIGSGAQGIV-CAAYDAVLD---RNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 KR+ + ++ +G G G V YD D VA+K L +P H +E+ +++ Sbjct: 34 KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIADLKKEIEILR 92 Query: 117 CVNHKNI--------------ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD 162 + H+NI I L+ F P +L+E YL NL Q ++ + Sbjct: 93 NLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKE----YLPKNKNKINLKQQLKYAV- 147 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 222 Q+ G+ +L S +HRDL N++V+S+ +KI DFGL + T Sbjct: 148 ---------QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYT 198 Query: 223 YVVTR----YYRAPEVILGMGYKENVDIWSVGCIMGEMVRH 259 R ++ APE ++ + D+WS G + E++ + Sbjct: 199 VKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTY 239 >4HZS-A nrPDB Length = 341 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/274 (25%), Positives = 118/274 (43%), Gaps = 25/274 (9%) Query: 54 GDSTFTVL---KRYQNLKPIGSGAQGIVC-AAYDAVLDR--NVAIKKLSRPFQNQTHAKR 107 G + T L K + L+ +G G+ G+V +DA + +VA+K L +Q A Sbjct: 1 GSQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD 60 Query: 108 AY-RELVLMKCVNHKNIISLLNVFT--PQKTLEEFQDVYLVMELMDANLCQVIQMELDHE 164 + RE+ M ++H+N+I L V P K + E + +++ + + + L Sbjct: 61 DFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTL--- 117 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMM 220 S Q+ G+ +L S IHRDL N+++ + +KI DFGL R + M Sbjct: 118 --SRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQ 175 Query: 221 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK----ILFPGRDYIDQWNKVI 276 V + APE + + D W G + EM + I G + + +K Sbjct: 176 EHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEG 235 Query: 277 EQLGTP--CPEFMKKLQPTVRNYV-ENRPKYAGL 307 E+L P CP+ + + + E+RP + L Sbjct: 236 ERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 269 >3SOC-A nrPDB Length = 322 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/263 (26%), Positives = 120/263 (45%), Gaps = 46/263 (17%) Query: 79 CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS------------- 125 C +L+ VA+K P Q++ + Y E+ + + H+NI+ Sbjct: 39 CVWKAQLLNEYVAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENILQFIGAEKRGTSVDV 95 Query: 126 ---LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 L+ F + +L +F +V LC + + R L++ + G+K H Sbjct: 96 DLWLITAFHEKGSLSDFLKANVVSW---NELCHIAET---MARGLAYLHEDIPGLKDGHK 149 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMT-PYVVTRYYRAPEVILG-M 238 I HRD+K N+++K++ T I DFGLA AG S T V TR Y APEV+ G + Sbjct: 150 PAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAI 209 Query: 239 GYKEN----VDIWSVGCIMGEMVRHKILFPG--RDYIDQWNKVIEQLGTPCPEFM----- 287 ++ + +D++++G ++ E+ G +Y+ + + I Q P E M Sbjct: 210 NFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQ--HPSLEDMQEVVV 267 Query: 288 -KKLQPTVRNYVENRPKYAGLTF 309 KK +P +R+Y + K+AG+ Sbjct: 268 HKKKRPVLRDYWQ---KHAGMAM 287 >1K9A-A nrPDB Length = 450 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 18/201 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +K + L+ IG G G D +L K + +N A+ E +M + H Sbjct: 192 MKELKLLQTIGKGEFG------DVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 245 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 175 N++ LL V +EE +Y+V E M +L ++ L + + + Sbjct: 246 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +++L +HRDL N++V D K+ DFGL + A ++ V + APE + Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL 358 Query: 236 LGMGYKENVDIWSVGCIMGEM 256 + D+WS G ++ E+ Sbjct: 359 REKKFSTKSDVWSFGILLWEI 379 >5GRN-A nrPDB Length = 356 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 45/225 (20%) Query: 70 IGSGAQGIVCAAYDAVLDRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNI 123 +GSGA G V L R+ VA+K L +P + + EL +M + H NI Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALMSELKIMTHLGPHLNI 112 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELM-------DANLCQVIQMELDHERMSYL------- 169 ++LL T + + +L+ D+ L + LD E + L Sbjct: 113 VNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEG 172 Query: 170 ---------LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-------- 212 YQ+ G++ L S +HRDL N+++ +KI DFGLAR Sbjct: 173 LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY 232 Query: 213 -TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM 256 + G++F+ ++ APE I Y D+WS G ++ E+ Sbjct: 233 VSKGSTFLPVKWM------APESIFDNLYTTLSDVWSYGILLWEI 271 >1BYG-A nrPDB Length = 278 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 86/201 (42%), Gaps = 18/201 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +K + L+ IG G G D +L K + +N A+ E +M + H Sbjct: 20 MKELKLLQTIGKGEFG------DVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRH 73 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 175 N++ LL V +EE +Y+V E M +L ++ L + + + Sbjct: 74 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 128 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +++L +HRDL N++V D K+ DFGL + A ++ V + APE + Sbjct: 129 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEAL 186 Query: 236 LGMGYKENVDIWSVGCIMGEM 256 + D+WS G ++ E+ Sbjct: 187 REKKFSTKSDVWSFGILLWEI 207 >1U54-B nrPDB Length = 291 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 65/270 (24%), Positives = 112/270 (41%), Gaps = 33/270 (12%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-R 110 ++GD +F V++R + P G +VA+K L +Q A + R Sbjct: 25 KLGDGSFGVVRRGEWDAPSGKTV--------------SVAVKCLKPDVLSQPEAMDDFIR 70 Query: 111 ELVLMKCVNHKNIISLLNVFT--PQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSY 168 E+ M ++H+N+I L V P K + E + +++ + + + L S Sbjct: 71 EVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTL-----SR 125 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYV 224 Q+ G+ +L S IHRDL N+++ + +KI DFGL R + M Sbjct: 126 YAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRK 185 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK----ILFPGRDYIDQWNKVIEQLG 280 V + APE + + D W G + EM + I G + + +K E+L Sbjct: 186 VPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLP 245 Query: 281 TP--CPEFMKKLQPTVRNYV-ENRPKYAGL 307 P CP+ + + + E+RP + L Sbjct: 246 RPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 275 >3LZB-A nrPDB Length = 327 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 93/208 (44%), Gaps = 25/208 (12%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKL---SRPFQNQTHAKRAYRELVLMK 116 ++ +K +GSGA G V + VAIK+L + P N+ AY +M Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY----VMA 72 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDHERMSYLL---YQ 172 V++ ++ LL + V L+ +LM L ++ D+ YLL Q Sbjct: 73 SVDNPHVCRLLGICLTS-------TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT---SFMMTPYVVTRYY 229 + G+ +L ++HRDL N++VK+ +KI DFGLA+ G + V + Sbjct: 126 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 185 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMV 257 A E IL Y D+WS G + E++ Sbjct: 186 MALESILHRIYTHQSDVWSYGVTVWELM 213 >5O2B-A nrPDB Length = 285 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 56/194 (28%), Positives = 88/194 (45%), Gaps = 10/194 (5%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V D VA +L + +R E ++K + H NI+ + Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL---LYQMLCGIKHLHSAG-- 184 + + L+ + + LV ELM + + + L Q+L G++ LH+ Sbjct: 84 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 185 IIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 IIHRDLK NI + ++KI D GLA TSF + + T + APE + Y E+ Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS-VIGTPEFMAPE-MYEEHYDES 199 Query: 244 VDIWSVGCIMGEMV 257 VD+++ G M EM Sbjct: 200 VDVYAFGMCMLEMA 213 >3SXS-A nrPDB Length = 268 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 88/205 (42%), Gaps = 34/205 (16%) Query: 67 LKPIGSGAQGIV-CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 LK +GSG G+V + D VA+K + + ++E M ++H ++ Sbjct: 13 LKELGSGQFGVVKLGKWKGQYD--VAVKMIK---EGSMSEDEFFQEAQTMMKLSHPKLVK 67 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-----LDHERMSYLLYQMLCGIKHL 180 V + + +Y+V E + +N C + + L+ ++ + Y + G+ L Sbjct: 68 FYGVCSKEYP------IYIVTEYI-SNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFL 120 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVVTRYYRA 231 S IHRDL N +V D +K+ DFG+ R + GT F + + A Sbjct: 121 ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVK-------WSA 173 Query: 232 PEVILGMGYKENVDIWSVGCIMGEM 256 PEV Y D+W+ G +M E+ Sbjct: 174 PEVFHYFKYSSKSDVWAFGILMWEV 198 >3ZZW-A nrPDB Length = 289 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 100/217 (46%), Gaps = 26/217 (11%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKC-VNHKNIISLLNVFTPQKTLEEFQDV------ 142 VAIK L + + + +R +++ + H N++ LL V T + L Sbjct: 42 VAIKTLKD--KAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDL 99 Query: 143 --YLVMELMDANLC-----QVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI 195 +LVM +++ + ++ L+ +L+ Q+ G+++L S ++H+DL N+ Sbjct: 100 HEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNV 159 Query: 196 VVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCI 252 +V +KI D GL R A ++ ++ + APE I+ + + DIWS G + Sbjct: 160 LVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVV 219 Query: 253 MGEMVRHKILFPGRDYIDQWNKVIEQLGT----PCPE 285 + E+ + L P Y +Q V+E + PCP+ Sbjct: 220 LWEVFSYG-LQPYCGYSNQ--DVVEMIRNRQVLPCPD 253 >4Y83-A nrPDB Length = 332 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 43/147 (29%), Positives = 73/147 (49%), Gaps = 11/147 (7%) Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVY---LVMELMDANLCQVIQMELDHERMSYLL 170 + C H+NI L +T+ F + V+E +++ C ++ E + + ++ Sbjct: 118 IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLES--CGPMR-EFE---IIWVT 171 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYY 229 +L G+ LHS +IH D+KPSNIV S + ++DFGL+ + + T Y Sbjct: 172 KHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIY 230 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEM 256 +PEVIL G+ DI+S+G + M Sbjct: 231 MSPEVILCRGHSTKADIYSLGATLIHM 257 >4X7Q-B nrPDB Length = 312 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 91/212 (42%), Gaps = 29/212 (13%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSR----PFQNQTHAKRAYRELVLMKCVN----HK 121 +G G G V A + VAIK + R + + + E+ L+ V H Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVME--LMDANLCQVI--QMELDHERMSYLLYQMLCGI 177 +I LL+ F Q + LV+E L +L I + L Q++ I Sbjct: 99 GVIRLLDWFETQ------EGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 152 Query: 178 KHLHSAGIIHRDLKPSNIVV--KSDCTLKILDFGLARTAGTSFMMTPYV---VTRYYRAP 232 +H HS G++HRD+K NI++ + C K++DFG +G PY TR Y P Sbjct: 153 QHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFG----SGALLHDEPYTDFDGTRVYSPP 207 Query: 233 EVILGMGYKE-NVDIWSVGCIMGEMVRHKILF 263 E I Y +WS+G ++ +MV I F Sbjct: 208 EWISRHQYHALPATVWSLGILLYDMVCGDIPF 239 >4JLC-A nrPDB Length = 657 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 47/159 (29%), Positives = 67/159 (42%), Gaps = 22/159 (13%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 163 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 55 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 110 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 219 +L ++ G+ HL GI+HRD+KP NI V+ D K+ DFG AR Sbjct: 111 SEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 170 Query: 220 MTPYVVTRYYRAPEV----IL----GMGYKENVDIWSVG 250 T Y P++ +L Y VD+WSVG Sbjct: 171 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVG 209 >4NFN-A nrPDB Length = 309 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 25/169 (14%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVL 114 + + V R++ LK IG G G + A D + NVA+K ++ K+ + E+ + Sbjct: 15 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAV 69 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY--- 171 +K + K+ + F E+F Y+VM+L NL + R ++ L Sbjct: 70 LKKLQGKDHVCR---FIGCGRNEKFN--YVVMQLQGRNLAD---LRRSQPRGTFTLSTTL 121 Query: 172 ----QMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLK---ILDFGLAR 212 Q+L I+ +HS G +HRD+KPSN + + T + +LDFGLAR Sbjct: 122 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 170 >3QGY-A nrPDB Length = 286 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 64/264 (24%), Positives = 111/264 (42%), Gaps = 44/264 (16%) Query: 67 LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 ++ IGSG G+V Y D+ VAIK + + E +M ++H ++ L Sbjct: 32 VQEIGSGQFGLVHLGYWLNKDK-VAIKTIK---EGSMSEDDFIEEAEVMMKLSHPKLVQL 87 Query: 127 LNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHERMSYLLYQMLCGIKHLHS 182 V Q + LV E M+ ++ + + E + + + G+ +L Sbjct: 88 YGVCLEQAP------ICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLAR---------TAGTSFMMTPYVVTRYYRAPE 233 A +IHRDL N +V + +K+ DFG+ R + GT F + + +PE Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK-------WASPE 194 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 V Y D+WS G +M E+ KI + R ++V+E + T + +L Sbjct: 195 VFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSN----SEVVEDISTGFRLYKPRLAS 250 Query: 293 T----VRNYV-----ENRPKYAGL 307 T + N+ E+RP ++ L Sbjct: 251 THVYQIMNHCWKERPEDRPAFSRL 274 >4BTK-A nrPDB Length = 337 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 25/169 (14%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVL 114 + + V R++ LK IG G G + A D + NVA+K ++ K+ + E+ + Sbjct: 50 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAV 104 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY--- 171 +K + K+ + F E+F Y+VM+L NL + R ++ L Sbjct: 105 LKKLQGKDHVCR---FIGCGRNEKFN--YVVMQLQGRNLAD---LRRSQPRGTFTLSTTL 156 Query: 172 ----QMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLK---ILDFGLAR 212 Q+L I+ +HS G +HRD+KPSN + + T + +LDFGLAR Sbjct: 157 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 205 >5U6B-A nrPDB Length = 307 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 31/234 (13%) Query: 68 KPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 K +G G G V D++L VA+K + ++ + E V MK +H N+ Sbjct: 29 KTLGEGEFGAVMEGQLNQDDSIL--KVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLLYQMLC------- 175 + L+ V E F +++ M +L + ++ YL QML Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 176 -GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAP-- 232 G+++L + IHRDL N ++ + ++ + DFGL++ + Y R + P Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKI---YNGDYYRQGRIAKMPVK 203 Query: 233 ----EVILGMGYKENVDIWSVGCIMGEM-VRHKILFPG------RDYIDQWNKV 275 E + Y D+WS G M E+ R + +PG DY+ Q N++ Sbjct: 204 WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRL 257 >6J5U-C nrPDB Length = 426 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 88/194 (45%), Gaps = 24/194 (12%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K+L +P Q H K E+ + ++H N++ L+ E ++ LV E M Sbjct: 121 VAVKQL-KPEGFQGH-KEWLTEVNYLGQLSHPNLVLLVGY------CAEGENRLLVYEFM 172 Query: 150 DANLCQVIQMELDHERMSYLLYQMLC-----GIKHLHSAG--IIHRDLKPSNIVVKSDCT 202 + + +++ + + G+ LH A +I+RD K +NI++ +D Sbjct: 173 PKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFN 232 Query: 203 LKILDFGLAR---TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRH 259 K+ DFGLA+ T + + T + T Y APE + D++S G ++ E++ Sbjct: 233 AKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELIS- 291 Query: 260 KILFPGRDYIDQWN 273 GR +D N Sbjct: 292 -----GRRAMDNSN 300 >4AT3-A nrPDB Length = 299 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 95/227 (41%), Gaps = 49/227 (21%) Query: 60 VLKRYQNLKPIGSGAQGIV--------CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 VLKR +G GA G V C D +L VA+K L N K +RE Sbjct: 16 VLKR-----ELGEGAFGKVFLAECYNLCPEQDKIL---VAVKTLKDASDNAR--KDFHRE 65 Query: 112 LVLMKCVNHKNIISLLNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQM-------EL 161 L+ + H++I+ V P + E+ + + + A+ + M EL Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 +M ++ Q+ G+ +L S +HRDL N +V + +KI DFG++R + Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS----- 180 Query: 222 PYVVTRYYRA------------PEVILGMGYKENVDIWSVGCIMGEM 256 T YYR PE I+ + D+WS+G ++ E+ Sbjct: 181 ----TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEI 223 >2OGV-A nrPDB Length = 317 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 95/207 (45%), Gaps = 21/207 (10%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHA---KRAYRELVLMKCVN-HKN 122 K +G+GA G V A L + A+ K++ + ++ HA + EL +M + H+N Sbjct: 44 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 103 Query: 123 IISLLNVFT---PQKTLEEFQDVYLVMELM----DANLCQVIQMELDHERMSYLLYQMLC 175 I++LL T P + E+ ++ + +A+L + L+ + + Q+ Sbjct: 104 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQ 163 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR----- 230 G+ L S IHRD+ N+++ + KI DFGLAR + Y+V R Sbjct: 164 GMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SNYIVKGNARLPVKW 220 Query: 231 -APEVILGMGYKENVDIWSVGCIMGEM 256 APE I Y D+WS G ++ E+ Sbjct: 221 MAPESIFDCVYTVQSDVWSYGILLWEI 247 >5WNO-A nrPDB Length = 330 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 88/207 (42%), Gaps = 31/207 (14%) Query: 68 KPIGSGAQGIVCAA-YDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVNHKNIIS 125 K +G+GA G V A Y +NV I + FQ +Q+ E M + H N++ Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLK 87 Query: 126 LLN------------VFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQM 173 ++ ++ P L+ F ++L NL E++ Y YQ+ Sbjct: 88 IIGFCMHDDGLKIVTIYRPLGNLQNF------LKLHKENLGA-------REQVLYC-YQI 133 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYR 230 G+++L ++HRDL N++VK ++I DFGL++ S + V + Sbjct: 134 ASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWL 193 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMV 257 A E+ Y D+W+ G E++ Sbjct: 194 AIEIFSKHCYTHASDVWAFGVTCWEII 220 >5E8V-A nrPDB Length = 316 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 49/163 (30%), Positives = 75/163 (46%), Gaps = 26/163 (15%) Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVIQME-LDHERMSYLLYQML 174 + H+NI+ L T ++ E Y ++ A NL + + + E + L + Sbjct: 66 LKHENILQFL---TAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLA 122 Query: 175 CGIKHLHSAG---------IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM----- 220 GI HLHS I+HRDLK SNI+VK+D T + DFGL+ + + Sbjct: 123 RGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLAN 182 Query: 221 TPYVVTRYYRAPEVILGMGYKENV------DIWSVGCIMGEMV 257 + V T Y APEV+ ENV D++S+ ++ EM Sbjct: 183 SGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMT 225 >2QLU-A nrPDB Length = 314 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 115/262 (43%), Gaps = 44/262 (16%) Query: 79 CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLE- 137 C +++ VA+K P Q++ + ++ RE+ + H+N++ + LE Sbjct: 30 CVWKAQLMNDFVAVKIF--PLQDK-QSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEV 86 Query: 138 ------EFQDVYLVMELMDAN------LCQVIQMELDHERMSYLLYQMLCGIKHLHSAGI 185 F D + + + N LC V E +SYL + H I Sbjct: 87 ELWLITAFHDKGSLTDYLKGNIITWNELCHV--AETMSRGLSYLHEDVPWCRGEGHKPSI 144 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLA------RTAGTSFMMTPYVVTRYYRAPEVILG-M 238 HRD K N+++KSD T + DFGLA + G + V TR Y APEV+ G + Sbjct: 145 AHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH---GQVGTRRYMAPEVLEGAI 201 Query: 239 GYKEN----VDIWSVGCIMGEMVRH---------KILFPGRDYIDQWNKVIEQLGTPCPE 285 ++ + +D++++G ++ E+V + + P + I Q + +E+L Sbjct: 202 NFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ-HPSLEELQEVV-- 258 Query: 286 FMKKLQPTVRNYVENRPKYAGL 307 KK++PT++++ P A L Sbjct: 259 VHKKMRPTIKDHWLKHPGLAQL 280 >5C26-A nrPDB Length = 299 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/154 (29%), Positives = 70/154 (45%), Gaps = 16/154 (10%) Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMT----P 222 L++Q+ G+K+L + +HRDL N+++ + KI DFGL++ A ++ Sbjct: 132 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 191 Query: 223 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIL----FPGRDYIDQWNKVIEQ 278 + V Y APE I + D+WS G +M E + G + K E+ Sbjct: 192 WPVKWY--APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ER 248 Query: 279 LGTP--CPEFMKKLQPTVRNY-VENRPKYAGLTF 309 +G P CP M L Y VENRP +A + Sbjct: 249 MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVEL 282 >4EUU-A nrPDB Length = 319 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 67/160 (41%), Gaps = 22/160 (13%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 163 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 111 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 219 +L ++ G+ HL GI+HR++KP NI V+ D K+ DFG AR Sbjct: 112 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 171 Query: 220 MTPYVVTRYYRAPEV----ILGMG----YKENVDIWSVGC 251 T Y P++ +L Y VD+WS+G Sbjct: 172 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 211 >6DBM-A nrPDB Length = 318 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 96/232 (41%), Gaps = 47/232 (20%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCA-AYDAVLDRN---VAIKKLSRPFQNQTHAKRAY 109 GD T + + ++ +G G G V YD D VA+K L Q H Sbjct: 23 GDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWK 81 Query: 110 RELVLMKCVNHKNII--------------SLLNVFTPQKTLEEFQDVYLVMELMDANLCQ 155 +E+ +++ + H++II L+ + P +L ++ + L Q Sbjct: 82 QEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY------LPRHSIGLAQ 135 Query: 156 VIQMELDHERMSYLLYQMLC-GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA 214 ++ L Q +C G+ +LHS IHRDL N+++ +D +KI DFGLA+ Sbjct: 136 LL-----------LFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAV 184 Query: 215 GTSFMMTPYVVTR-------YYRAPEVILGMGYKENVDIWSVGCIMGEMVRH 259 Y R ++ APE + + D+WS G + E++ H Sbjct: 185 PEGH---EYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTH 233 >4CRS-A nrPDB Length = 341 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/166 (28%), Positives = 84/166 (50%), Gaps = 6/166 (3%) Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHE-RMSYLLY 171 + + VN L+N+F +T E V VME +L I ++ E R + Sbjct: 65 IFETVNSVRHPFLVNLFACFQTKEH---VCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAA 121 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYR 230 ++ G+++LH I++RDLK N+++ ++ +KI DFGL + G + + T + Sbjct: 122 CVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFL 181 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 APEV+ Y VD W +G ++ EM+ + FPG D + ++ ++ Sbjct: 182 APEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIV 227 >4M66-A nrPDB Length = 325 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/165 (27%), Positives = 84/165 (50%), Gaps = 16/165 (9%) Query: 54 GDSTFTVLKR--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 G S ++ R + L+ +G G G+V A+ + +VA+K ++ +K+ E Sbjct: 10 GASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWE 61 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHER--MSY 168 + M + ++N++ LL V T + LV M+ +L ++Q E + Sbjct: 62 VKAMVNLRNENVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCR 120 Query: 169 LLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLA 211 LL +++ G+ +LHS ++HRDLKPSNI++ + K+ DFGL+ Sbjct: 121 LLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLS 165 >4FL3-A nrPDB Length = 635 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/186 (27%), Positives = 85/186 (45%), Gaps = 19/186 (10%) Query: 138 EFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 194 E + LVME+ + L + +Q + + + L++Q+ G+K+L + +HRDL N Sbjct: 440 EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARN 499 Query: 195 IVVKSDCTLKILDFGLART--AGTSFMMT----PYVVTRYYRAPEVILGMGYKENVDIWS 248 +++ + KI DFGL++ A ++ + V Y APE I + D+WS Sbjct: 500 VLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY--APECINYYKFSSKSDVWS 557 Query: 249 VGCIMGEMVRHKIL----FPGRDYIDQWNKVIEQLGTP--CPEFMKKLQPTVRNY-VENR 301 G +M E + G + K E++G P CP M L Y VENR Sbjct: 558 FGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCPAGCPREMYDLMNLCWTYDVENR 616 Query: 302 PKYAGL 307 P +A + Sbjct: 617 PGFAAV 622 >4EUT-A nrPDB Length = 396 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 67/160 (41%), Gaps = 22/160 (13%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 163 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 56 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 111 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 219 +L ++ G+ HL GI+HR++KP NI V+ D K+ DFG AR Sbjct: 112 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 171 Query: 220 MTPYVVTRYYRAPEV----IL----GMGYKENVDIWSVGC 251 T Y P++ +L Y VD+WS+G Sbjct: 172 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 211 >4OTD-A nrPDB Length = 341 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/171 (27%), Positives = 83/171 (48%), Gaps = 11/171 (6%) Query: 110 RELVLMKCVNHKNIISLLNVF-TPQKTLEEFQDVYLVMEL-MDANLCQVIQMELDHE-RM 166 R L + H +++L F TP+ V VME +L I ++ E R Sbjct: 64 RILAAVTSAGHPFLVNLFGCFQTPEH-------VCFVMEYSAGGDLMLHIHSDVFSEPRA 116 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVV 225 + ++ G++ LH I++RDLK N+++ ++ +KI DFGL + G + + Sbjct: 117 IFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCG 176 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 T + APEV+ Y VD W +G ++ EM+ + FPG D + ++ ++ Sbjct: 177 TPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 227 >2BUJ-A nrPDB Length = 317 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 80/178 (44%), Gaps = 22/178 (12%) Query: 100 QNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ 158 Q + A RE + + NH NI+ L+ ++ + + +L++ L I+ Sbjct: 65 HEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAK--HEAWLLLPFFKRGTLWNEIE 122 Query: 159 ME------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-- 210 L +++ +LL + G++ +H+ G HRDLKP+NI++ + ++D G Sbjct: 123 RLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMN 182 Query: 211 --------ARTAGTSFMMTPYVVTRYYRAPEVILGMGY---KENVDIWSVGCIMGEMV 257 +R A T T YRAPE+ + E D+WS+GC++ M+ Sbjct: 183 QACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM 240 >6NT9-A nrPDB Length = 742 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 22/159 (13%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 163 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 54 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 109 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 219 +L ++ G+ HL GI+HR++KP NI V+ D K+ DFG AR Sbjct: 110 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 169 Query: 220 MTPYVVTRYYRAPEV----IL----GMGYKENVDIWSVG 250 T Y P++ +L Y VD+WS+G Sbjct: 170 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIG 208 >1U59-A nrPDB Length = 287 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 80/182 (43%), Gaps = 22/182 (12%) Query: 89 NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 +VAIK L + + + + RE +M +++ I+ L+ V + + LVME+ Sbjct: 39 DVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM-------LVMEM 90 Query: 149 MDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 + E+ ++ LL+Q+ G+K+L +HRDL N+++ + K Sbjct: 91 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAK 150 Query: 205 ILDFGLARTAGTSFMMTPYVVTRY-------YRAPEVILGMGYKENVDIWSVGCIMGEMV 257 I DFGL++ G Y R + APE I + D+WS G M E + Sbjct: 151 ISDFGLSKALGAD---DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 207 Query: 258 RH 259 + Sbjct: 208 SY 209 >6FER-A nrPDB Length = 309 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 60/248 (24%), Positives = 102/248 (41%), Gaps = 43/248 (17%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K L R N+ +E+ +M + NII LL V L ++ E M Sbjct: 53 VAVKML-RADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPL------CMITEYM 105 Query: 150 D-ANLCQVIQME------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 + +L Q + + + + ++ Q+ G+K+L S +HRDL N + Sbjct: 106 ENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCL 165 Query: 197 VKSDCTLKILDFGLART--AGTSFMMTPYVV--TRYYRAPEVILGMGYKENVDIWSVGCI 252 V + T+KI DFG++R +G + + V R+ ++LG + D+W+ G Sbjct: 166 VGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLG-KFTTASDVWAFGVT 224 Query: 253 MGEMVRHKILFPGRDYIDQWNKVIEQLG---------------TPCPEFMKKLQPTV-RN 296 + E P D+ +VIE G CP+ + KL + R Sbjct: 225 LWETFTFCQEQPYSQLSDE--QVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRR 282 Query: 297 YVENRPKY 304 +NRP + Sbjct: 283 DTKNRPSF 290 >6O8B-A nrPDB Length = 665 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 22/159 (13%) Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDH 163 RE ++K +NHKNI+ L + T + L+ME + E L Sbjct: 62 REFEVLKKLNHKNIVKLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPE 117 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI--VVKSD--CTLKILDFGLARTAGTSFM 219 +L ++ G+ HL GI+HR++KP NI V+ D K+ DFG AR Sbjct: 118 SEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQ 177 Query: 220 MTPYVVTRYYRAPEV----IL----GMGYKENVDIWSVG 250 T Y P++ +L Y VD+WS+G Sbjct: 178 FVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIG 216 >4OLI-A nrPDB Length = 645 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 93/212 (43%), Gaps = 22/212 (10%) Query: 62 KRY-QNLKPIGSGAQGIVCA-AYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMK 116 KRY + ++ +G G G V YD D VA+K L Q H +E+ +++ Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQEIDILR 410 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLLYQMLC 175 + H++II Q + + LVME + +L + L Q +C Sbjct: 411 TLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQIC 466 Query: 176 -GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR------- 227 G+ +LHS IHR+L N+++ +D +KI DFGLA+ Y R Sbjct: 467 EGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGH---EYYRVREDGDSPV 523 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRH 259 ++ APE + + D+WS G + E++ H Sbjct: 524 FWYAPECLKEYKFYYASDVWSFGVTLYELLTH 555 >3Q4U-A nrPDB Length = 301 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/227 (27%), Positives = 93/227 (40%), Gaps = 34/227 (14%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 TV + L+ +G G G V + NVA+K S K +RE L V Sbjct: 5 TVARDITLLECVGKGRYGEVWRG--SWQGENVAVKIFS-----SRDEKSWFRETELYNTV 57 Query: 119 --NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-LDHERMSYLLYQML 174 H+NI+ + + + ++L+ + +L +Q+ LD ++ + Sbjct: 58 MLRHENILGF--IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIA 115 Query: 175 CGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLA-----RTAGTSFMMT 221 G+ HLH I HRDLK NI+VK + I D GLA T Sbjct: 116 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNN 175 Query: 222 PYVVTRYYRAPEVILGM-------GYKENVDIWSVGCIMGEMVRHKI 261 P V T+ Y APEV+ YK VDIW+ G ++ E+ R + Sbjct: 176 PRVGTKRYMAPEVLDETIQVDCFDSYKR-VDIWAFGLVLWEVARRMV 221 >3MDY-A nrPDB Length = 337 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 99/221 (44%), Gaps = 28/221 (12%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T+ K+ Q +K IG G G V VA+K + + + VLM+ Sbjct: 34 TIAKQIQMVKQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMR-- 89 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ-MELDHERMSYLLYQMLCG 176 H+NI+ + K + +YL+ + + +L ++ LD + M L Y + G Sbjct: 90 -HENILGF--IAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSG 146 Query: 177 IKHLHSA--------GIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTP---Y 223 + HLH+ I HRDLK NI+VK + T I D GLA + T+ + P Sbjct: 147 LCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTR 206 Query: 224 VVTRYYRAPEVI---LGMGYKEN---VDIWSVGCIMGEMVR 258 V T+ Y PEV+ L + ++ D++S G I+ E+ R Sbjct: 207 VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVAR 247 >5X02-A nrPDB Length = 347 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 109/249 (43%), Gaps = 41/249 (16%) Query: 45 DNQFYSVEVGDSTFTVLKRY--QNL---KPIGSGAQGIVCAAYDAVLDRN-----VAIKK 94 DN+++ V+ + + + + +NL K +GSGA G V A + + VA+K Sbjct: 26 DNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKM 85 Query: 95 LSRPFQNQTHAKRAYRELVLM-KCVNHKNIISLLNVFT---PQKTLEEFQDVYLVMELMD 150 L + + + EL +M + +H+NI++LL T P + E+ ++ + Sbjct: 86 LKEK-ADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLR 144 Query: 151 ANLCQVIQMELDHERMSYL-----------------LYQMLCGIKHLHSAGIIHRDLKPS 193 + + + E+++E L YQ+ G++ L +HRDL Sbjct: 145 SKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAAR 204 Query: 194 NIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR------APEVILGMGYKENVDIW 247 N++V +KI DFGLAR + + YVV R APE + Y D+W Sbjct: 205 NVLVTHGKVVKICDFGLARDIMSD---SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVW 261 Query: 248 SVGCIMGEM 256 S G ++ E+ Sbjct: 262 SYGILLWEI 270 >5X1R-A nrPDB Length = 302 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 29/166 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKK-----LSRPFQNQTHAKRAYR-------------- 110 IG G GIV AYD L+R +AIK+ L++ + + R R Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSFIQ 88 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERM 166 E L+ +H ++ +L + EE Y+ + + +Q + +D + Sbjct: 89 EARLLARFSHPGLLHVLRFW------EENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWI 142 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 LL + I +H G +HRD+ NI ++ +LDFG AR Sbjct: 143 RRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >2OZO-A nrPDB Length = 613 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 45/182 (24%), Positives = 80/182 (43%), Gaps = 22/182 (12%) Query: 89 NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 +VAIK L + + + + RE +M +++ I+ L+ V + + LVME+ Sbjct: 365 DVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM-------LVMEM 416 Query: 149 MDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 + E+ ++ LL+Q+ G+K+L +HR+L N+++ + K Sbjct: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAK 476 Query: 205 ILDFGLARTAGTSFMMTPYVVTRY-------YRAPEVILGMGYKENVDIWSVGCIMGEMV 257 I DFGL++ G Y R + APE I + D+WS G M E + Sbjct: 477 ISDFGLSKALGAD---DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 Query: 258 RH 259 + Sbjct: 534 SY 535 >5HLW-A nrPDB Length = 299 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 90/202 (44%), Gaps = 22/202 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 IG G G C + +LD + A+K L+R + + E ++MK +H N++ Sbjct: 28 IGRGHFG--CVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLL---YQMLCGIKHL 180 SLL + L +V+ M +L I+ E + + L+ Q+ G+K+L Sbjct: 85 SLLGI-----CLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL 139 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY-----YRAPEVI 235 S +HRDL N ++ T+K+ DFGLAR + + T + A E + Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 236 LGMGYKENVDIWSVGCIMGEMV 257 + D+WS G ++ E++ Sbjct: 200 QTQKFTTKSDVWSFGVLLWELM 221 >4LRM-A nrPDB Length = 334 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 91/210 (43%), Gaps = 26/210 (12%) Query: 64 YQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKL---SRPFQNQTHAKRAYRELVLMK 116 ++ +K +GSGA G V + VAIK+L + P N+ AY V+ Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY---VMAS 77 Query: 117 CVNHKN--IISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDHERMSYLL--- 170 N N + LL + V L+ +LM L ++ D+ YLL Sbjct: 78 VDNPGNPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWC 130 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT---SFMMTPYVVTR 227 Q+ G+ +L ++HRDL N++VK+ +KI DFGLA+ G + V Sbjct: 131 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPI 190 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 + A E IL Y D+WS G + E++ Sbjct: 191 KWMALESILHRIYTHQSDVWSYGVTVWELM 220 >3BBT-B nrPDB Length = 328 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 99/226 (43%), Gaps = 36/226 (15%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYREL-- 112 T LKR +K +GSGA G V + VAIK L N+T +A E Sbjct: 15 TELKR---VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-----NETTGPKANVEFMD 66 Query: 113 --VLMKCVNHKNIISLLNV-FTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHERMSY 168 ++M ++H +++ LL V +P + LV +LM L + + D+ Sbjct: 67 EALIMASMDHPHLVRLLGVCLSPT--------IQLVTQLMPHGCLLEYVHEHKDNIGSQL 118 Query: 169 LL---YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTP 222 LL Q+ G+ +L ++HRDL N++VKS +KI DFGLAR + Sbjct: 119 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG 178 Query: 223 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDY 268 + + A E I + D+WS G + E+ + F G+ Y Sbjct: 179 GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWEL----MTFGGKPY 220 >6FEX-A nrPDB Length = 321 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 49/184 (26%), Positives = 81/184 (44%), Gaps = 20/184 (10%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K L RP + +E+ +M + NII LL V L D ME Sbjct: 60 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY---MENG 115 Query: 150 DAN-LCQVIQME------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 D N Q+E + + + ++ Q+ G+++L + +HRDL N + Sbjct: 116 DLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCL 175 Query: 197 VKSDCTLKILDFGLART--AGTSFMMTPYVVTRY-YRAPEVILGMGYKENVDIWSVGCIM 253 V + T+KI DFG++R AG + + V + A E IL + D+W+ G + Sbjct: 176 VGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTL 235 Query: 254 GEMV 257 E++ Sbjct: 236 WEVL 239 >3V5Q-A nrPDB Length = 297 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 93/228 (40%), Gaps = 48/228 (21%) Query: 60 VLKRYQNLKPIGSGAQGIV----CAAYDAVLDRN-VAIKKLSRPFQNQTHAKRAYRELVL 114 VLKR +G GA G V C D+ VA+K L P K RE L Sbjct: 18 VLKR-----ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP--TLAARKDFQREAEL 70 Query: 115 MKCVNHKNIISLLNV------------FTPQKTLEEFQDVYL--VMELMDANLCQVIQME 160 + + H++I+ V + L +F + M L+D Q + E Sbjct: 71 LTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA-KGE 129 Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 L +M ++ Q+ G+ +L S +HRDL N +V ++ +KI DFG++R + Sbjct: 130 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS---- 185 Query: 221 TPYVVTRYYRA------------PEVILGMGYKENVDIWSVGCIMGEM 256 T YYR PE I+ + D+WS G I+ E+ Sbjct: 186 -----TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 228 >3HNG-A nrPDB Length = 360 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 31/89 (34%), Positives = 45/89 (50%), Gaps = 3/89 (3%) Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY-- 228 +Q+ G++ L S IHRDL NI++ + +KI DFGLAR + TR Sbjct: 206 FQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPL 265 Query: 229 -YRAPEVILGMGYKENVDIWSVGCIMGEM 256 + APE I Y D+WS G ++ E+ Sbjct: 266 KWMAPESIFDKIYSTKSDVWSYGVLLWEI 294 >3C1X-A nrPDB Length = 373 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 89/202 (44%), Gaps = 22/202 (10%) Query: 70 IGSGAQGIVCAAYDAVLDRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 IG G G C + +LD + A+K L+R + + E ++MK +H N++ Sbjct: 97 IGRGHFG--CVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLL---YQMLCGIKHL 180 SLL + L +V+ M +L I+ E + + L+ Q+ G+K L Sbjct: 154 SLLGI-----CLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFL 208 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-----GTSFMMTPYVVTRYYRAPEVI 235 S +HRDL N ++ T+K+ DFGLAR + T + + A E + Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL 268 Query: 236 LGMGYKENVDIWSVGCIMGEMV 257 + D+WS G ++ E++ Sbjct: 269 QTQKFTTKSDVWSFGVLLWELM 290 >3KRL-A nrPDB Length = 335 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 91/213 (42%), Gaps = 27/213 (12%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRA---YRELVLMKCVN-HKN 122 K +G+GA G V A L + A+ K++ + ++ HA EL +M + H+N Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 123 IISLLNVFT---PQKTLEEFQDVYLVMELM----------DANLCQVIQMELDHERMSYL 169 I++LL T P + E+ ++ + N + +L + + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHF 171 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 Q+ G+ L S IHRD+ N+++ + KI DFGLAR + Y+V Sbjct: 172 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SNYIVKGNA 228 Query: 230 R------APEVILGMGYKENVDIWSVGCIMGEM 256 R APE I Y D+WS G ++ E+ Sbjct: 229 RLPVKWMAPESIFDCVYTVQSDVWSYGILLWEI 261 >3M42-A nrPDB Length = 299 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 71/303 (23%), Positives = 118/303 (38%), Gaps = 81/303 (26%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM----KCVNHKNIIS 125 +G G G V ++ A+K L +A RE+ L +C + I+ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 78 Query: 126 LL-NVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKH 179 + N++ +K L +VME +D L IQ D ER S ++ + I++ Sbjct: 79 VYENLYAGRKCL------LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 180 LHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 LHS I HRD+KP N++ S + LK+ DFG A+ Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET---------------------T 171 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 G Y ++ D+WS+G IM IL G P F + Sbjct: 172 GEKYDKSCDMWSLGVIM------YILLCG-----------------YPPFYSNHGLAISP 208 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 ++ R + FP P SE + + + L+ +L +P +R+++ + + H Sbjct: 209 GMKTRIRMGQYEFPN-------PEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNH 257 Query: 357 PYI 359 P+I Sbjct: 258 PWI 260 >5TOS-A nrPDB Length = 395 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 106/240 (44%), Gaps = 41/240 (17%) Query: 50 SVEVGDSTFTVLK-RYQNLKP---IGSGAQGIVCAAYDAVLDRN------------VAIK 93 S V TF LK +N +P IG G G V + LD + +A+K Sbjct: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGW---LDESTLTPTKPGTGLVIAVK 105 Query: 94 KLSRP-FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN 152 KL++ FQ + E+ + ++H N++ L+ LE+ + LV E M Sbjct: 106 KLNQEGFQGH---REWLTEINYLGQLSHPNLVKLIGY-----CLED-EHRLLVYEFMQKG 156 Query: 153 LCQ--VIQMELDHERMSYLLYQMLC-----GIKHLHS--AGIIHRDLKPSNIVVKSDCTL 203 + + + + + + L + G+ LHS +I+RD+K SNI++ +D Sbjct: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 Query: 204 KILDFGLAR---TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK 260 K+ DFGLAR S++ T + T Y APE + D++S G ++ E++ K Sbjct: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 >4XLV-A nrPDB Length = 328 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 101/237 (42%), Gaps = 44/237 (18%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 SV V D ++ L+ +G G+ G+V + + A +++ N++ + R Sbjct: 27 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRER 86 Query: 110 RELV----LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMEL 161 E + +MK +++ LL V + + Q +VMELM + + ++ E Sbjct: 87 IEFLNEASVMKGFTCHHVVRLLGVVS------KGQPTLVVMELMAHGDLKSYLRSLRPEA 140 Query: 162 DH---------ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 ++ + M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ R Sbjct: 141 ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTR 200 Query: 213 TAGTSFMMTPYVVTRYYR------------APEVILGMGYKENVDIWSVGCIMGEMV 257 T YYR APE + + + D+WS G ++ E+ Sbjct: 201 D---------IYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 248 >3BEA-A nrPDB Length = 333 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 91/211 (43%), Gaps = 25/211 (11%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHA---KRAYRELVLMKCVN-HKN 122 K +G+GA G V A L + A+ K++ + ++ HA + EL +M + H+N Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 111 Query: 123 IISLLNVFT---PQKTLEEF---QDVYLVMELMDANL-----CQVIQMELDHERMSYLLY 171 I++LL T P + E+ D+ + L + L + + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSS 171 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR- 230 Q+ G+ L S IHRD+ N+++ + KI DFGLAR + Y+V R Sbjct: 172 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SNYIVKGNARL 228 Query: 231 -----APEVILGMGYKENVDIWSVGCIMGEM 256 APE I Y D+WS G ++ E+ Sbjct: 229 PVKWMAPESIFDCVYTVQSDVWSYGILLWEI 259 >3PP0-A nrPDB Length = 338 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 86/205 (41%), Gaps = 21/205 (10%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV----LMKCVNH 120 + +K +GSGA G V NV I + + T K A +E++ +M V Sbjct: 20 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPK-ANKEILDEAYVMAGVGS 78 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSY-----LLYQMLC 175 + LL + V LV +LM C + + + R+ Q+ Sbjct: 79 PYVSRLLGICLTST-------VQLVTQLMPYG-CLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMMTPYVVTRYYRAP 232 G+ +L ++HRDL N++VKS +KI DFGLAR T + V + A Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMAL 190 Query: 233 EVILGMGYKENVDIWSVGCIMGEMV 257 E IL + D+WS G + E++ Sbjct: 191 ESILRRRFTHQSDVWSYGVTVWELM 215 >6BSD-A nrPDB Length = 876 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 81/190 (42%), Gaps = 26/190 (13%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K L RP + +E+ +M + NII LL V L D ME Sbjct: 615 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY---MENG 670 Query: 150 DAN-LCQVIQME------------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDL 190 D N Q+E + + + ++ Q+ G+++L + +HRDL Sbjct: 671 DLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDL 730 Query: 191 KPSNIVVKSDCTLKILDFGLART--AGTSFMMTPYVVTRY-YRAPEVILGMGYKENVDIW 247 N +V + T+KI DFG++R AG + + V + A E IL + D+W Sbjct: 731 ATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVW 790 Query: 248 SVGCIMGEMV 257 + G + E++ Sbjct: 791 AFGVTLWEVL 800 >4E20-A nrPDB Length = 290 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 22/210 (10%) Query: 62 KRY-QNLKPIGSGAQGIVCA-AYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMK 116 KRY + ++ +G G G V YD D VA+K L Q + RE+ +++ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIEILR 65 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLLYQMLC 175 + H++I+ Q + V LVME + +L + L Q +C Sbjct: 66 TLYHEHIVKYKGCCEDQGE----KSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQIC 121 Query: 176 -GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR------- 227 G+ +LH+ IHR L N+++ +D +KI DFGLA+ Y R Sbjct: 122 EGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGH---EYYRVREDGDSPV 178 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 ++ APE + + D+WS G + E++ Sbjct: 179 FWYAPECLKECKFYYASDVWSFGVTLYELL 208 >4XUF-A nrPDB Length = 297 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 95/221 (42%), Gaps = 36/221 (16%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN-----VAIKKLSRPFQNQTHAKRAYRELVLM-KCVNHK 121 K +GSGA G V A + + VA+K L + + + EL +M + +H+ Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEK-ADSSEREALMSELKMMTQLGSHE 73 Query: 122 NIISLLNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL--------- 169 NI++LL T P + E+ ++ + + + + E+++E L Sbjct: 74 NIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVL 133 Query: 170 --------LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 YQ+ G++ L +HRDL N++V +KI DFGLAR + + Sbjct: 134 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD---S 190 Query: 222 PYVVTRYYR------APEVILGMGYKENVDIWSVGCIMGEM 256 YVV R APE + Y D+WS G ++ E+ Sbjct: 191 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEI 231 >2H34-A nrPDB Length = 309 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/199 (27%), Positives = 92/199 (46%), Gaps = 14/199 (7%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ-THAKRAYRELVLMKCVNHKN 122 Y+ + +G G G V A D V +R VA+K +S + R RE + + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVI--QMELDHERMSYLLYQMLCGIKH 179 ++ + + L Y+ M L++ +L ++ Q L R ++ Q+ + Sbjct: 96 VVPIHDFGEIDGQL------YVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY---VVTRYYRAPEVIL 236 H+AG HRD+KP NI+V +D ++DFG+A +A T +T V T YY APE Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIA-SATTDEKLTQLGNTVGTLYYMAPERFS 208 Query: 237 GMGYKENVDIWSVGCIMGE 255 DI+++ C++ E Sbjct: 209 ESHATYRADIYALTCVLYE 227 >4RT7-A nrPDB Length = 415 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/102 (32%), Positives = 48/102 (47%), Gaps = 9/102 (8%) Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 L E + YQ+ G++ L +HRDL N++V +KI DFGLAR + Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD--- 296 Query: 221 TPYVVTRYYR------APEVILGMGYKENVDIWSVGCIMGEM 256 + YVV R APE + Y D+WS G ++ E+ Sbjct: 297 SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEI 338 >3QUP-A nrPDB Length = 323 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/216 (22%), Positives = 90/216 (41%), Gaps = 16/216 (7%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K L + + RE MK +H ++ L+ V + +++ M Sbjct: 54 VAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFM 113 Query: 150 DANLCQVIQM---------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD 200 + L + + + + CG+++L S IHRDL N ++ D Sbjct: 114 KHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAED 173 Query: 201 CTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGYKENVDIWSVGCIMGE-M 256 T+ + DFGL+R + ++ + A E + Y + D+W+ G M E M Sbjct: 174 MTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIM 233 Query: 257 VRHKILFPGRDYIDQWNKVI--EQLGTPCPEFMKKL 290 R + + G + + +N +I +L P PE M+++ Sbjct: 234 TRGQTPYAGIENAEIYNYLIGGNRLKQP-PECMEEV 268 >4LQP-A nrPDB Length = 508 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 95/200 (47%), Gaps = 21/200 (10%) Query: 25 DKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVL-------KRYQNLKPIGSGAQGI 77 +++V++ +N S+ + Q S+ +S F L + + +K IG GA G Sbjct: 58 ERRVELETELTSHNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGE 117 Query: 78 VCAAYDAVLDRNVAIKKLSRP---FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQK 134 V + A+K L + ++Q +A R++ + + ++SL F Sbjct: 118 VRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV--LAGSDSPWVVSLYYSF---- 171 Query: 135 TLEEFQDVYLVMELMDAN--LCQVIQMELDHERMS-YLLYQMLCGIKHLHSAGIIHRDLK 191 ++ Q +YL+ME + + +I+ +L E ++ + + + + I+ +H G IHR +K Sbjct: 172 --QDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIK 229 Query: 192 PSNIVVKSDCTLKILDFGLA 211 P NI++ +K+ DFGL+ Sbjct: 230 PDNILIDIRGHIKLSDFGLS 249 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 17/27 (62%) Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGE 255 Y APE+ L GY + D WS+G IM E Sbjct: 329 YIAPEIFLYQGYGQECDWWSLGAIMYE 355 >5O0Y-A nrPDB Length = 579 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 85/198 (42%), Gaps = 24/198 (12%) Query: 78 VCAAYDAVLDRNVAIK-----KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTP 132 V A+D R VA+K K R + + + K A RE + K ++H I+ L + F+ Sbjct: 300 VYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSL 359 Query: 133 QKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAG--IIHRDL 190 + F V E D + + + ++ Q++ +K+L+ IIH DL Sbjct: 360 --DTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDL 417 Query: 191 KPSNIVVKSDCT---LKILDFGLAR-------TAGTSFMMTPYVVTRYYRAPEVILGMGY 240 KP NI++ + +KI DFGL++ + +T Y+ P +G Sbjct: 418 KPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGK 477 Query: 241 K-----ENVDIWSVGCIM 253 + VD+WSVG I Sbjct: 478 EPPKISNKVDVWSVGVIF 495 >3VHK-A nrPDB Length = 368 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 11/93 (11%) Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR--- 227 +Q+ G++ L S IHRDL NI++ +KI DFGLAR P V + Sbjct: 207 FQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR----DIYKDPDYVRKGDA 262 Query: 228 ----YYRAPEVILGMGYKENVDIWSVGCIMGEM 256 + APE I Y D+WS G ++ E+ Sbjct: 263 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEI 295 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 31/69 (44%), Gaps = 5/69 (7%) Query: 68 KPIGSGAQGIVCAAYDAVLD-----RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 KP+G GA G V A +D R VA+K L + H +L+ +H N Sbjct: 35 KPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLN 94 Query: 123 IISLLNVFT 131 +++LL T Sbjct: 95 VVNLLGACT 103 >4R7H-A nrPDB Length = 343 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 34/220 (15%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRA---YRELVLMKCVN-HKN 122 K +G+GA G V A L + A+ K++ + ++ HA EL +M + H+N Sbjct: 56 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHEN 115 Query: 123 IISLLNVFT---PQKTLEEFQDVYLVMELM----DANLCQVIQMELDHERMS-------- 167 I++LL T P + E+ ++ + +A L + D E + Sbjct: 116 IVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLE 175 Query: 168 -----YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 222 + Q+ G+ L S IHRD+ N+++ + KI DFGLAR + Sbjct: 176 LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND---SN 232 Query: 223 YVVTRYYR------APEVILGMGYKENVDIWSVGCIMGEM 256 Y+V R APE I Y D+WS G ++ E+ Sbjct: 233 YIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEI 272 >5IKW-A nrPDB Length = 310 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 94/234 (40%), Gaps = 50/234 (21%) Query: 73 GAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA------KRAY-----------RELVLM 115 G + + L+ ++A S F +TH KR Y RE+ +M Sbjct: 5 GVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIM 64 Query: 116 KCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL---LY 171 K ++ HKNI+ L+ + +V ++ME A QV+ + + + Sbjct: 65 KELSGHKNIVGYLDC-AVNSISDNVWEVLILMEYCRAG--QVVNQMNKKLQTGFTEPEVL 121 Query: 172 QMLC----GIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY-- 223 Q+ C + LH IIHRDLK NI++ + DFG A T+ + P Sbjct: 122 QIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSA----TNKFLNPQKD 177 Query: 224 -----------VVTRYYRAPEVILGMGYK---ENVDIWSVGCIMGEMVRHKILF 263 T YRAPE+I G K DIW++GC++ ++ + F Sbjct: 178 GVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >2PMN-X nrPDB Length = 348 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 58/252 (23%), Positives = 109/252 (43%), Gaps = 55/252 (21%) Query: 131 TPQKTLEEFQDVYLVMELMDANLCQVIQME-----LDHERMSYLLYQML-CGIK------ 178 T + + + +VY++ E M+ + +++ + LD ++ Q++ C IK Sbjct: 107 TCEGIITNYDEVYIIYEYMEND--SILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSF 164 Query: 179 -HLHS-AGIIHRDLKPSNIVVKSDCTLKILDFG---------LARTAGTSFMMTPYVVTR 227 ++H+ I HRD+KPSNI++ + +K+ DFG + + GT M P Sbjct: 165 SYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPP----E 220 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 ++ G VDIWS+G + Y+ +N V L E Sbjct: 221 FFSNESSYNGAK----VDIWSLGICL--------------YVMFYNVVPFSLKISLVELF 262 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 ++ Y +R + L+P + + +N L +++ D L L +PA+R Sbjct: 263 NNIRTKNIEYPLDRNHF-------LYPLTNKKSTCSNNFL-SNEDIDFLKLFLRKNPAER 314 Query: 348 ISVDDALQHPYI 359 I+ +DAL+H ++ Sbjct: 315 ITSEDALKHEWL 326 >5OAT-A nrPDB Length = 411 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 90/212 (42%), Gaps = 30/212 (14%) Query: 120 HKNIISLLNVFT-------PQKTLEEFQ----DVYLVMELMDANLCQVIQMELDHERMSY 168 H NI+++ +VFT P + E + ++L+M+ D NL + Sbjct: 98 HPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLL 157 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS----DCTLKILDFGLA---RTAGTSFMMT 221 LL Q+L G+ H+ + GI HRDLK N+++ + L I DFG +T G S T Sbjct: 158 LLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYT 217 Query: 222 PYVVTR----YYRAPEVILG-------MGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 Y + + APE+I + Y + D+W+VG I E+ F G + Sbjct: 218 SYEMDKGGNTALMAPEIICQKPGTFSVLNYSK-ADLWAVGAIAYEIFNCHNPFYGPSRLK 276 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 +N L E +Q V N ++ P Sbjct: 277 NFNYKEGDLPKLPDEVPTVIQALVANLLKRNP 308 >5FM2-A nrPDB Length = 355 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 9/93 (9%) Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR 230 +Q+ G+++L ++HRDL NI+V +KI DFGL+R + YV R Sbjct: 198 WQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---YEEDSYVKRSQGR 254 Query: 231 AP------EVILGMGYKENVDIWSVGCIMGEMV 257 P E + Y D+WS G ++ E+V Sbjct: 255 IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 287 >3I81-A nrPDB Length = 315 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 96/223 (43%), Gaps = 54/223 (24%) Query: 68 KPIGSGAQGIV--CAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELV----LMKCV 118 + +G G+ G+V A V D VAIK + N+ + R E + +MK Sbjct: 24 RELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV-----NEAASMRERIEFLNEASVMKEF 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHE---------R 165 N +++ LL V + + Q ++MELM + + ++ E+++ + Sbjct: 79 NCHHVVRLLGVVS------QGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSK 132 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ R Sbjct: 133 MIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI---------YE 183 Query: 226 TRYYR------------APEVILGMGYKENVDIWSVGCIMGEM 256 T YYR +PE + + D+WS G ++ E+ Sbjct: 184 TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEI 226 >2QKW-B nrPDB Length = 321 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 90/196 (45%), Gaps = 20/196 (10%) Query: 74 AQGIVCAAYDAVL--DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFT 131 G+ Y VL VA+K+ + P +Q + L C H +++SL+ F Sbjct: 48 GHGVFGKVYKGVLRDGAKVALKRRT-PESSQGIEEFETEIETLSFC-RHPHLVSLIG-FC 104 Query: 132 PQKTLEEFQDVYLVMELMDANLCQ-VIQMELDHERMSYLLYQMLC-----GIKHLHSAGI 185 ++ E +Y ME + NL + + +L MS+ +C G+ +LH+ I Sbjct: 105 DERN--EMILIYKYME--NGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAPEVILGMGYK 241 IHRD+K NI++ + KI DFG+++ GT + T T Y PE + Sbjct: 161 IHRDVKSINILLDENFVPKITDFGISKK-GTELDQTHLSTVVKGTLGYIDPEYFIKGRLT 219 Query: 242 ENVDIWSVGCIMGEMV 257 E D++S G ++ E++ Sbjct: 220 EKSDVYSFGVVLFEVL 235 >5TE0-A nrPDB Length = 347 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/191 (25%), Positives = 85/191 (44%), Gaps = 23/191 (12%) Query: 95 LSRPFQNQTH-AKRAYRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DA 151 L R F N H + RE+ +M+ ++ HKNI+ ++ + + +V ++M+ Sbjct: 48 LKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG 107 Query: 152 NLCQVIQMELDHERMSYLLYQMLC----GIKHLHSAG--IIHRDLKPSNIVVKSDCTLKI 205 + ++ L + Q+ C + LH IIHRDLK NI++ + Sbjct: 108 QVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVL 167 Query: 206 LDFGLA-------RTAGTSFM---MTPYVVTRYYRAPEVI---LGMGYKENVDIWSVGCI 252 DFG A +T G + + + Y T YRAPE++ G DIW++GC+ Sbjct: 168 CDFGSATNKFQNPQTEGVNAVEDEIKKY-TTLSYRAPEMVNLYSGKIITTKADIWALGCL 226 Query: 253 MGEMVRHKILF 263 + ++ + F Sbjct: 227 LYKLCYFTLPF 237 >5AMN-A nrPDB Length = 299 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 9/93 (9%) Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR 230 +Q+ G+++L ++HRDL NI+V +KI DFGL+R + YV R Sbjct: 143 WQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---YEEDSYVKRSQGR 199 Query: 231 AP------EVILGMGYKENVDIWSVGCIMGEMV 257 P E + Y D+WS G ++ E+V Sbjct: 200 IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 232 >5FQD-C nrPDB Length = 341 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 + F V +Y+ ++ IGSG+ G + A + VA+K S Q H + Y E L Sbjct: 13 AEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLES---QKARHPQLLY-ESKLY 68 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY---Q 172 K + I + + +K LVM+L+ +L + M +L Q Sbjct: 69 KILQGGVGIPHIRWYGQEKDYN-----VLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQ 123 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIV--VKSDCT-LKILDFGLAR 212 M+ I+++H+ IHRD+KP N + + C L ++DFGLA+ Sbjct: 124 MISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAK 166 >4CI6-B nrPDB Length = 643 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 6/86 (6%) Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMTPYV 224 + ++ +++L HL AGI+H D+KP N+V ++ ++D GL +G P Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQ----PKG 213 Query: 225 VTRYYRAPEVILG-MGYKENVDIWSV 249 T ++APE+ +G +G E D++ V Sbjct: 214 FTESFKAPELGVGNLGASEKSDVFLV 239 >5LPZ-A nrPDB Length = 332 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 88/210 (41%), Gaps = 22/210 (10%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRN--VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNH 120 + N IGSG G V Y A+L VAIKKL R + E+ + + H Sbjct: 19 FHNDSLIGSGGFGDV---YKAILKDGSAVAIKKL---IHVSGQGDREFMAEMETIGKIKH 72 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVME-------LMDANLCQVIQMELDHERMSYLLYQM 173 +N++ LL K +E VY M+ L D V +++ + Sbjct: 73 RNLVPLLGYC---KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYR 230 L + H S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHK 260 PE D++S G ++ E++ K Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGK 219 >5LPV-A nrPDB Length = 296 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 88/210 (41%), Gaps = 22/210 (10%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRN--VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNH 120 + N IGSG G V Y A+L VAIKKL R + E+ + + H Sbjct: 19 FHNDSLIGSGGFGDV---YKAILKDGSAVAIKKL---IHVSGQGDREFMAEMETIGKIKH 72 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVME-------LMDANLCQVIQMELDHERMSYLLYQM 173 +N++ LL K +E VY M+ L D V +++ + Sbjct: 73 RNLVPLLGYC---KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYR 230 L + H S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHK 260 PE D++S G ++ E++ K Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGK 219 >1PY5-A nrPDB Length = 326 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 19/114 (16%) Query: 164 ERMSYLLYQMLCGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLA---R 212 E M L G+ HLH I HRDLK NI+VK + T I D GLA Sbjct: 126 EGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHD 185 Query: 213 TAGTSFMMTP--YVVTRYYRAPEVI---LGMGYKEN---VDIWSVGCIMGEMVR 258 +A + + P V T+ Y APEV+ + M + E+ DI+++G + E+ R Sbjct: 186 SATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 239 >4XHL-A nrPDB Length = 394 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 34/58 (58%), Gaps = 8/58 (13%) Query: 163 HERMSY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLAR 212 H R S+ L QM C I+++H IHRD+KP N ++ + T+ ++DFGL++ Sbjct: 97 HRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSK 154 >4Y12-A nrPDB Length = 375 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 92/195 (47%), Gaps = 13/195 (6%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDA-VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 V +Y+ I G G + A D V R V +K L + A L + V Sbjct: 117 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 176 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELD-HERMSYLLYQMLCG 176 H +I+ + N F Y+VME + +L + +L E ++YLL ++L Sbjct: 177 -HPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLL-EILPA 233 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG-LARTAGTSFMMTPYVVTRYYRAPEVI 235 + +LHS G+++ DLKP NI++ + LK++D G ++R ++ T ++APE++ Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYG----TPGFQAPEIV 288 Query: 236 LGMGYKENVDIWSVG 250 G DI++VG Sbjct: 289 R-TGPTVATDIYTVG 302 >2PZI-A nrPDB Length = 681 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 14/215 (6%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDA-VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 V +Y+ I G G + A D V R V +K L + A L + V Sbjct: 78 VAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV 137 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELD-HERMSYLLYQMLCG 176 H +I+ + N F Y+VME + +L + +L E ++YLL ++L Sbjct: 138 -HPSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLL-EILPA 194 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG-LARTAGTSFMMTPYVVTRYYRAPEVI 235 + +LHS G+++ DLKP NI++ + LK++D G ++R ++ T ++APE++ Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYG----TPGFQAPEIV 249 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 G DI++VG + + GR Y+D Sbjct: 250 R-TGPTVATDIYTVGRTLAALTLDLPTRNGR-YVD 282 >1LUF-A nrPDB Length = 343 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 90/233 (38%), Gaps = 48/233 (20%) Query: 67 LKPIGSGAQGIVCAAYDAVL-----DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++ IG GA G V A L VA+K L A RE LM ++ Sbjct: 52 VRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALMAEFDNP 110 Query: 122 NIISLLNVFT---PQKTLEEFQDVYLVMELMDA----NLCQVIQMELD-HERMSY----- 168 NI+ LL V P L E+ + E + + +C + +L R+S Sbjct: 111 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPP 170 Query: 169 --------LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 + Q+ G+ +L +HRDL N +V + +KI DFGL+R ++ Sbjct: 171 LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSA--- 227 Query: 221 TPYVVTRYYRA------------PEVILGMGYKENVDIWSVGCIMGEMVRHKI 261 YY+A PE I Y D+W+ G ++ E+ + + Sbjct: 228 ------DYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL 274 >4H1J-A nrPDB Length = 293 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 102/241 (42%), Gaps = 38/241 (15%) Query: 89 NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 NVA+K + + ++ E V+MK ++H +I+ L+ + + T +++MEL Sbjct: 54 NVAVKTCKKDC-TLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPT-------WIIMEL 105 Query: 149 MDANLCQVIQMELDH--ER-------MSYLLY--QMLCGIKHLHSAGIIHRDLKPSNIVV 197 EL H ER ++ +LY Q+ + +L S +HRD+ NI+V Sbjct: 106 YPYG-------ELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILV 158 Query: 198 KSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGYKENVDIWSVGCIMG 254 S +K+ DFGL+R VTR + +PE I + D+W M Sbjct: 159 ASPECVKLGDFGLSRYIEDEDYYKA-SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMW 217 Query: 255 EMVRHK----ILFPGRDYIDQWNKVIEQLGTP--CPEFMKKLQPTVRNY-VENRPKYAGL 307 E++ +D I K ++L P CP + L +Y +RP++ L Sbjct: 218 EILSFGKQPFFWLENKDVIGVLEKG-DRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 276 Query: 308 T 308 Sbjct: 277 V 277 >2VD5-A nrPDB Length = 412 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 73/164 (44%), Gaps = 21/164 (12%) Query: 139 FQD---VYLVMEL-MDANLCQVIQM---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLK 191 FQD +YLVME + +L ++ + E + L +++ I +H G +HRD+K Sbjct: 130 FQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIK 189 Query: 192 PSNIVVKSDCTLKILDFGLA---RTAGTSFMMTPYVVTRYYRAPEVILGMGYKE------ 242 P NI++ +++ DFG R GT + V T Y +PE++ +G Sbjct: 190 PDNILLDRCGHIRLADFGSCLKLRADGTVRSLVA-VGTPDYLSPEILQAVGGGPGTGSYG 248 Query: 243 -NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI---EQLGTP 282 D W++G EM + F + + K++ E L P Sbjct: 249 PECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 292 >5AR8-A nrPDB Length = 326 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 80/157 (50%), Gaps = 17/157 (10%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS--RPFQNQTHAKRAYRELVLMKCVNHKNI 123 +L+ + GA G V +A A VA+K L P + + K RE ++ I Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLD-SERKDVLREAEILHKARFSYI 94 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHERMSY-----LLYQMLCGI 177 + +L + E + + +V E M + +L +++ + ++ +++ +L+++ G+ Sbjct: 95 LPILGI------CNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 148 Query: 178 KHLH--SAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 +LH + ++H DLK NI++ ++ +KI DFGL++ Sbjct: 149 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >5KMM-A nrPDB Length = 329 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 78/197 (39%), Gaps = 47/197 (23%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K L +++ + RE L+ + H++I+ V T E + + +V E M Sbjct: 68 VAVKALKEA--SESARQDFQREAELLTMLQHQHIVRFFGVCT------EGRPLLMVFEYM 119 Query: 150 --------------DANLC----QVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLK 191 DA L V L ++ + Q+ G+ +L +HRDL Sbjct: 120 RHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA 179 Query: 192 PSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA------------PEVILGMG 239 N +V +KI DFG++R + T YYR PE IL Sbjct: 180 TRNCLVGQGLVVKIGDFGMSRDIYS---------TDYYRVGGRTMLPIRWMPPESILYRK 230 Query: 240 YKENVDIWSVGCIMGEM 256 + D+WS G ++ E+ Sbjct: 231 FTTESDVWSFGVVLWEI 247 >5XD6-A nrPDB Length = 305 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 12/102 (11%) Query: 176 GIKHLHSAG---IIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYY 229 G+++LH +IHRD+K SN+++ D KI DF L+ A T + T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 APE + D++S G ++ E L GR +D Sbjct: 198 HAPEYAMTGTLSTKSDVYSFGVVLLE------LLTGRKPVDH 233 >4XHH-A nrPDB Length = 403 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 35/58 (60%), Gaps = 8/58 (13%) Query: 163 HERMSY-----LLYQMLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLAR 212 H + S+ L QM+C ++++H IHRD+KP N ++ + T+ ++DFGL++ Sbjct: 97 HRKFSFKTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSK 154 >4M69-B nrPDB Length = 283 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/222 (21%), Positives = 93/222 (41%), Gaps = 36/222 (16%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKT-------LEEFQDVYLVMELMDANLCQVIQMELDH 163 E+ MK + NI+ + + Q + E+ ++ + EL+D + +L Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR------EKDLTM 111 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT------- 216 S L+ + G+ LH + +HR++ S+ +V +K+ F L++T + Sbjct: 112 SVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 171 Query: 217 ----SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG------R 266 T YV + P + Y +I+S G ++ E+ KI F G R Sbjct: 172 TKAERSSSTIYVSPERLKNPFCL----YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIR 227 Query: 267 DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV-ENRPKYAGL 307 + + + +K E +G CPE ++++ R + RP G+ Sbjct: 228 ELVAE-DKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 268 >4TN6-A nrPDB Length = 318 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/163 (27%), Positives = 73/163 (44%), Gaps = 23/163 (14%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK----KLSRPFQNQTHAKRAYRELVLM 115 V RY+ + IGSG+ G + D VAIK K P Q H + Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP---QLH----------I 51 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQ 172 + +K + + + T + E +VMEL+ +L + + + + L Q Sbjct: 52 ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQ 111 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLAR 212 M+ I+++HS IHRD+KP N ++ K + I+DFGLA+ Sbjct: 112 MISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAK 154 >4BTF-A nrPDB Length = 469 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/222 (21%), Positives = 93/222 (41%), Gaps = 36/222 (16%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKT-------LEEFQDVYLVMELMDANLCQVIQMELDH 163 E+ MK + NI+ + + Q + E+ ++ + EL+D + +L Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR------EKDLTM 297 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT------- 216 S L+ + G+ LH + +HR++ S+ +V +K+ F L++T + Sbjct: 298 SVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 357 Query: 217 ----SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG------R 266 T YV + P + Y +I+S G ++ E+ KI F G R Sbjct: 358 TKAERSSSTIYVSPERLKNPFCL----YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIR 413 Query: 267 DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV-ENRPKYAGL 307 + + + +K E +G CPE ++++ R + RP G+ Sbjct: 414 ELVAE-DKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 454 >2Y4I-B nrPDB Length = 319 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 70/153 (45%), Gaps = 18/153 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG G G V Y VAI+ + N+ K RE++ + H+N++ + Sbjct: 41 IGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 130 -FTPQK-----TLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 +P +L + + +Y V+ DA + LD + + +++ G+ +LH+ Sbjct: 98 CMSPPHLAIITSLCKGRTLYSVVR--DAKIV------LDVNKTRQIAQEIVKGMGYLHAK 149 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 216 GI+H+DLK N V + + I DFGL +G Sbjct: 150 GILHKDLKSKN-VFYDNGKVVITDFGLFSISGV 181 >5CLR-A nrPDB Length = 451 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 16/33 (48%), Positives = 23/33 (69%) Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG 209 +K H G+IHRDLKP NI++ +D ++DFG Sbjct: 189 VKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG 221 >4JRN-A nrPDB Length = 372 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/253 (21%), Positives = 103/253 (40%), Gaps = 59/253 (23%) Query: 44 VDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK---------- 93 V +F SV G+ T T+++ P+GSG V A D + +A+K Sbjct: 55 VPKRFVSVTTGE-TRTLVRG----APLGSGGFATVYEATDVETNEELAVKVFMSEKEPTD 109 Query: 94 -------KLSRPFQNQTHAKRAY-----------RELVLMKC--VNHKNIISLLNVFTPQ 133 + S ++N + AK A ++V+++ + + +I L + P Sbjct: 110 ETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVP- 168 Query: 134 KTLEEFQDVYLVMELMDANLCQVIQMELDHERMS----------YLLYQMLCGIKHLHSA 183 + +L+M +A++ +VI ++ YL Q + + ++ + Sbjct: 169 -------NYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQ 221 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE---VILGMGY 240 GI+H D+KP+N ++ D L + DFG R + + + T Y PE G+ Y Sbjct: 222 GIVHTDIKPANFLLLKDGRLFLGDFGTYRINNS---VGRAIGTPGYEPPERPFQATGITY 278 Query: 241 KENVDIWSVGCIM 253 D W +G + Sbjct: 279 TFPTDAWQLGITL 291 >4F0G-A nrPDB Length = 287 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 89/204 (43%), Gaps = 28/204 (13%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAY----RELVLMKCVNHKN 122 K IG G G+V VAIK L + +T + RE+ +M +NH N Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 123 IISLLNVF-TPQKTLEEF---QDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 I+ L + P + + EF D+Y L+D ++L L+ + GI+ Sbjct: 85 IVKLYGLMHNPPRMVMEFVPCGDLY--HRLLDKAHPIKWSVKLR------LMLDIALGIE 136 Query: 179 HLHSAG--IIHRDLKPSNIVVKS-----DCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 ++ + I+HRDL+ NI ++S K+ DFGL++ + S ++ + + A Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS--VSGLLGNFQWMA 194 Query: 232 PEVILG--MGYKENVDIWSVGCIM 253 PE I Y E D +S I+ Sbjct: 195 PETIGAEEESYTEKADTYSFAMIL 218 >3SV0-A nrPDB Length = 483 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 14/136 (10%) Query: 144 LVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--- 197 LVM+L+ +L + +L + + L QM+ ++ +HS +HRD+KP N ++ Sbjct: 80 LVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLG 139 Query: 198 KSDCTLKILDFGLART--AGTSFMMTPY------VVTRYYRAPEVILGMGYKENVDIWSV 249 + + I+DFGLA+ ++ PY T Y + LG+ D+ S+ Sbjct: 140 RRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNTHLGIEQSRRDDLESL 199 Query: 250 GCIMGEMVRHKILFPG 265 G ++ +R + + G Sbjct: 200 GYVLMYFLRGSLPWQG 215 >5U6C-A nrPDB Length = 315 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 42/189 (22%), Positives = 79/189 (41%), Gaps = 14/189 (7%) Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K + +Q + E MK +H N++ LL V + + +++ M Sbjct: 67 VAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSS-QGIPKPMVILPFM 125 Query: 150 DAN------LCQVIQMELDHERMSYLLYQML---CGIKHLHSAGIIHRDLKPSNIVVKSD 200 L ++ H + LL M+ G+++L + +HRDL N +++ D Sbjct: 126 KYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDD 185 Query: 201 CTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILGMGYKENVDIWSVGCIMGEM- 256 T+ + DFGL++ + + + + A E + Y D+W+ G M E+ Sbjct: 186 MTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIA 245 Query: 257 VRHKILFPG 265 R +PG Sbjct: 246 TRGMTPYPG 254 >3ZBF-A nrPDB Length = 322 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 89/219 (40%), Gaps = 45/219 (20%) Query: 70 IGSGAQGIV--CAAYDAVL----DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 +GSGA G V A D + + VA+K L + +Q + +E LM NH NI Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE-FLKEAHLMSKFNHPNI 99 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL--------LYQMLC 175 + L V L E Q Y+++ELM+ + L RM+ LC Sbjct: 100 LKQLGVCL----LNEPQ--YIILELMEGG---DLLTYLRKARMATFYGPLLTLVDLVDLC 150 Query: 176 -----GIKHLHSAGIIHRDLKPSNIVVK-----SDCTLKILDFGLARTAGTSFMMTPYVV 225 G +L IHRDL N +V S +KI DFGLAR Y Sbjct: 151 VDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLAR----DIYKNDYYR 206 Query: 226 TR-------YYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 R + APE ++ + D+WS G ++ E++ Sbjct: 207 KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEIL 245 >5J0A-A nrPDB Length = 300 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/192 (23%), Positives = 86/192 (44%), Gaps = 29/192 (15%) Query: 91 AIKKLSRPFQN----QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM 146 A+KK++ P N + KR E ++K ++H NI+ + E D L + Sbjct: 41 AVKKIN-PICNDHYRSVYQKRLMDEAKILKSLHHPNIVGY-------RAFTEANDGSLCL 92 Query: 147 ELM---DANLCQVIQMELDHERMSY-------LLYQMLCGIKHLH-SAGIIHRDLKPSNI 195 + + +L +I+ + + + M G+K+LH ++H D+K SN+ Sbjct: 93 AMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNV 152 Query: 196 VVKSDC-TLKILDFGLARTAGTSFMMTP----YVVTRYYRAPEVILGMGY-KENVDIWSV 249 V+K D T+KI D G++ + +T Y+ T ++ E + G + DI++ Sbjct: 153 VIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAF 212 Query: 250 GCIMGEMVRHKI 261 G + EM+ I Sbjct: 213 GLTLWEMMTLSI 224 >5WNL-A nrPDB Length = 342 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 8/104 (7%) Query: 140 QDVYLVMELMD-ANLCQVIQME-LDHERMSYLLYQMLCGIKHLH--SAGIIHRDLKPSNI 195 + V LVME M+ +L +++ E L + ++++ G+ LH S ++H +LKP+NI Sbjct: 90 EPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANI 149 Query: 196 VVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPEVI 235 ++ + +KI DFGLA+ G S M T Y PE I Sbjct: 150 LLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERI 193 >4IX6-A nrPDB Length = 350 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 28/44 (63%), Gaps = 2/44 (4%) Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSDCTLKILDFGLA 211 + ++L + LH G++HRD+KP+N++ K LK++D G A Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >5L2Q-C nrPDB Length = 320 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/190 (23%), Positives = 82/190 (43%), Gaps = 43/190 (22%) Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLAR-TAGTSFMMTPYVVT 226 + Y ++ ++ LH I+HRDLK N+V+ K + I +F L + ++ + Sbjct: 158 IFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGS 217 Query: 227 RYYRAPEVILGMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Y +P+V+ G Y+ D+W++G ++ M+ + FP D I Q E Sbjct: 218 PAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQ--FPFYDSIPQ-------------E 262 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 +K+ K A T P E ++ + L+ K+LV+DP Sbjct: 263 LFRKI------------KAAEYTIP------------EDGRVSENTV-CLIRKLLVLDPQ 297 Query: 346 KRISVDDALQ 355 +R++ D L+ Sbjct: 298 QRLAAADVLE 307 >3LMG-A nrPDB Length = 344 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/200 (20%), Positives = 89/200 (44%), Gaps = 11/200 (5%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR----ELVLMKCVNH 120 + LK +GSG G V ++ I + ++++ +++++ ++ + ++H Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKS-GRQSFQAVTDHMLAIGSLDH 92 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 +I+ LL P +L+ + L+D + + L + + Q+ G+ +L Sbjct: 93 AHIVRLLG-LCPGSSLQLVTQYLPLGSLLDH--VRQHRGALGPQLLLNWGVQIAKGMYYL 149 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILG 237 G++HR+L N+++KS +++ DFG+A Y + + A E I Sbjct: 150 EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHF 209 Query: 238 MGYKENVDIWSVGCIMGEMV 257 Y D+WS G + E++ Sbjct: 210 GKYTHQSDVWSYGVTVWELM 229 >5VC6-A nrPDB Length = 289 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 18/144 (12%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKN 122 + L+ IGSG G V + AIK+ +P + A RE+ + H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER-MSY--------LLYQM 173 ++ + + +D +++++ N + ++ R MSY LL Q+ Sbjct: 73 VVRYFSAWA--------EDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQV 124 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVV 197 G++++HS ++H D+KPSNI + Sbjct: 125 GRGLRYIHSMSLVHMDIKPSNIFI 148 >4F9B-A nrPDB Length = 361 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 53/132 (40%), Gaps = 32/132 (24%) Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFM-- 219 E Y+L + +K +H GI+HRD+KPSN + ++DFGLA+ + + Sbjct: 117 QEVREYML-NLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIEL 175 Query: 220 ---------------------------MTPYVVTRYYRAPEVILGMGYKEN-VDIWSVGC 251 + P T +RAPEV+ + +D+WS G Sbjct: 176 LKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGV 235 Query: 252 IMGEMVRHKILF 263 I ++ + F Sbjct: 236 IFLSLLSGRYPF 247 >3UIM-A nrPDB Length = 326 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 88/212 (41%), Gaps = 20/212 (9%) Query: 64 YQNLKPIGSGAQGIVCAAY--DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + N +G G G V D L VA+K+L + Q + E+ ++ H+ Sbjct: 32 FSNKNILGRGGFGKVYKGRLADGTL---VAVKRLKEE-RTQGGELQFQTEVEMISMAVHR 87 Query: 122 NIISLLNV-FTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCG 176 N++ L TP + L VY M C + E LD + + G Sbjct: 88 NLLRLRGFCMTPTERLL----VYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARG 143 Query: 177 IKHLHS---AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG--TSFMMTPYVVTRYYRA 231 + +LH IIHRD+K +NI++ + + DFGLA+ + + T T + A Sbjct: 144 LAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIA 203 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILF 263 PE + E D++ G ++ E++ + F Sbjct: 204 PEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >2CMW-A nrPDB Length = 310 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 31/46 (67%), Gaps = 5/46 (10%) Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLAR 212 Q+L ++++HS +I+RD+KP N ++ K + + I+DFGLA+ Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAK 150 >2WTK-B nrPDB Length = 373 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 68/168 (40%), Gaps = 21/168 (12%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHER 165 EL + K NH NI+ F L ++V M +C ++ Sbjct: 60 ELHVSKLFNHPNIVPYRATFIADNEL------WVVTSFMAYGSAKDLICTHFMDGMNELA 113 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLARTAGTSFMMTPY 223 ++Y+L +L + ++H G +HR +K S+I++ D L L L+ + + Sbjct: 114 IAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVH 173 Query: 224 VVTRY------YRAPEVILG--MGYKENVDIWSVGCIMGEMVRHKILF 263 +Y + +PEV+ GY DI+SVG E+ + F Sbjct: 174 DFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 >3AOX-A nrPDB Length = 344 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/217 (21%), Positives = 84/217 (38%), Gaps = 40/217 (18%) Query: 67 LKPIGSGAQGIVCAAYDAVLDRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++ +G GA G V + + + VA+K L Q L++ K NH+ Sbjct: 52 IRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISK-FNHQ 110 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----------LDHERMSYLLY 171 NI+ + V ++L F +++ELM + E L + ++ Sbjct: 111 NIVRCIGVSL--QSLPRF----ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVAR 164 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDC---TLKILDFGLA---------RTAGTSFM 219 + CG ++L IHRD+ N ++ KI DFG+A R G + + Sbjct: 165 DIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAML 224 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM 256 ++ PE + + D WS G ++ E+ Sbjct: 225 PVKWM------PPEAFMEGIFTSKTDTWSFGVLLWEI 255 >1CSN-A nrPDB Length = 298 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 34/158 (21%), Positives = 75/158 (47%), Gaps = 19/158 (12%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKN 122 Y+ + IG G+ G++ + + ++ VAIK R + + YR +L C N Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRR-SDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIKH 179 + + Q+ L LV++L+ +L ++ + + + ++ QML ++ Sbjct: 71 V-----YYFGQEGLHNV----LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQS 121 Query: 180 LHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLAR 212 +H +++RD+KP N ++ K+ + ++DFG+ + Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 >4NT4-A nrPDB Length = 312 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 31/46 (67%), Gaps = 5/46 (10%) Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLAR 212 Q+L I+++HS +I+RD+KP N ++ K + + I+DFGLA+ Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >6EQI-C nrPDB Length = 433 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 21/135 (15%) Query: 142 VYLVMELMDANLCQVIQMELDHERMSYLLYQMLC-GIKHLHSAGIIHRDLKPSNIVV--- 197 ++LVM+ D L + ++ + + R S LL L + H++ I HRDLK NI+V Sbjct: 144 LFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLKSDNILVDLS 203 Query: 198 KSDC--TLKILDFGLARTAGTSFMMTPYVV-------TRYYRAPEVILG-------MGYK 241 + D T+ I DFG + ++ PY R APE+ + YK Sbjct: 204 EGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKPGTFSWLNYK 263 Query: 242 ENVDIWSVGCIMGEM 256 ++ D+W+VG I E+ Sbjct: 264 KS-DLWAVGAIAYEI 277 >5VE6-A nrPDB Length = 492 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 27/40 (67%), Gaps = 1/40 (2%) Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 R+ +LL Q+ G++HL GIIHRDL N+++ CTL+ Sbjct: 209 RVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL-VHCTLQ 247 >2C47-A nrPDB Length = 313 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 30/46 (65%), Gaps = 5/46 (10%) Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLAR 212 Q++ ++++H+ +I+RD+KP N +V K + I+DFGLA+ Sbjct: 108 QLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAK 153 >5X18-A nrPDB Length = 295 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 71/157 (45%), Gaps = 17/157 (10%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K IG G+ G++ + + VAIK R +T A + E K +N Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPR----KTEAPQLRDEYKTYKILNGTPN 64 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIKHL 180 I F Q+ L LV++L+ +L + + + + + QM+ I+ L Sbjct: 65 IPYAYYFG-QEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDL 119 Query: 181 HSAGIIHRDLKPSNIVVKSDC-----TLKILDFGLAR 212 H+ +I+RD+KP N ++ + ++DFG+A+ Sbjct: 120 HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 >6EWX-A nrPDB Length = 484 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 25/38 (65%) Query: 160 ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 197 E+ R+ +LL Q+ G++HL GIIHRDL N+++ Sbjct: 206 EVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >2CHL-A nrPDB Length = 351 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 30/46 (65%), Gaps = 5/46 (10%) Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLAR 212 Q++ ++++HS +I+RD+KP N ++ K+ + I+DF LA+ Sbjct: 134 QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAK 179 >4AZV-A nrPDB Length = 569 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 6/76 (7%) Query: 137 EEFQDVYLVMELMDANLCQ---VIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193 E Q +LVME + L E+D E+ +L +L + L G H D++P Sbjct: 312 ENAQSGWLVMEKLPGRLLSDMLAAGEEIDREK---ILGSLLRSLAALEKQGFWHDDVRPW 368 Query: 194 NIVVKSDCTLKILDFG 209 N++V + +++DFG Sbjct: 369 NVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 35.8 bits (81), Expect = 0.045, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 6/76 (7%) Query: 137 EEFQDVYLVMELMDANLCQ---VIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193 E Q +LVME + L E+D E+ +L +L + L G H D++P Sbjct: 312 ENAQSGWLVMEKLPGRLLSDMLAAGEEIDREK---ILGSLLRSLAALEKKGFWHDDVRPW 368 Query: 194 NIVVKSDCTLKILDFG 209 N++V + +++DFG Sbjct: 369 NVMVDARQHARLIDFG 384 >3ENH-A nrPDB Length = 540 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 34/146 (23%), Positives = 63/146 (43%), Gaps = 11/146 (7%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 IG GA+ + D+ LD +V IK+ + R+ + + ++ + Sbjct: 344 IGKGAEADI--KRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQ-VIQMELDHERMSYLLYQMLCGIKHLHSAGIIHR 188 P + + ++M ++ L + VI+ LD + Y++ + LH +IH Sbjct: 402 PAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLD------IAYKIGEIVGKLHKNDVIHN 455 Query: 189 DLKPSNIVVKSDCTLKILDFGLARTA 214 DL SN + D L I+DFGL + + Sbjct: 456 DLTTSNFIFDKD--LYIIDFGLGKIS 479 >4L68-A nrPDB Length = 340 Score = 35.0 bits (79), Expect = 0.071, Method: Compositional matrix adjust. Identities = 55/229 (24%), Positives = 89/229 (38%), Gaps = 38/229 (16%) Query: 105 AKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME------LMDANLCQVI 157 +R +R E+ + + H N+ LL ++ E+F VY M L+D+N Sbjct: 78 GEREFRYEMNQLWELRHSNLAPLLGFCVVEE--EKFL-VYKYMSNGTLHSLLDSN----- 129 Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAG---IIHRDLKPSNIVVKSDCTLKILDFGLARTA 214 + ELD + G+ LH I+H+++ S I++ D +I+D GLAR Sbjct: 130 RGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLM 189 Query: 215 -----GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDY- 268 S MT + Y APE M D++ +G ++ E+ G + Sbjct: 190 VPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGGEGFK 249 Query: 269 --IDQWNKVIEQLGTPCPEF------------MKKLQPTVRNYVENRPK 303 + W K +E G F + K N V +RPK Sbjct: 250 GSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPK 298 >6BFN-A nrPDB Length = 342 Score = 35.0 bits (79), Expect = 0.072, Method: Compositional matrix adjust. Identities = 18/38 (47%), Positives = 25/38 (65%), Gaps = 2/38 (5%) Query: 177 IKHLH--SAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 I+ LH S +IH D+K SN+++ T K+ DFGLAR Sbjct: 138 IQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLAR 175 >6G4J-A nrPDB Length = 315 Score = 34.7 bits (78), Expect = 0.096, Method: Compositional matrix adjust. Identities = 37/151 (24%), Positives = 59/151 (39%), Gaps = 12/151 (7%) Query: 143 YLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DC 201 + ME + L + E + L+ Q+L + LH G I DLKP N++V Sbjct: 102 FYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPA 161 Query: 202 TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE---NVDIWSVGCIMGEMVR 258 ++ +D G G + R Y G G ++ + D+++V IM V Sbjct: 162 RIRCIDVGGTTKEGRAIKEYTEFYDRGY------WGYGTRKAEPSYDLFAVAMIMINSVH 215 Query: 259 HKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 K +Q +IE G P + KK Sbjct: 216 KKEFKKTNQPKEQLRSLIE--GNPLLQKYKK 244 >4YFF-A nrPDB Length = 311 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 54/242 (22%), Positives = 101/242 (41%), Gaps = 15/242 (6%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 S + K +M+K K D + L + + IGSG+ G V ++ V Sbjct: 11 SPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG--RCRNKIV 68 Query: 91 AIKKL-SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 AIK+ + + +++ RE+ ++ +NH +I + + Q + + Sbjct: 69 AIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPS----QFAIVTQYIS 124 Query: 150 DANLCQVIQME---LDHERMSYLLYQMLCGIKHLH--SAGIIHRDLKPSNIVVKSDCTLK 204 +L ++ + LD + + + G+++LH + IIHRDL NI++ D Sbjct: 125 GGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAV 184 Query: 205 ILDFGLARTAGT--SFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKI 261 + DFG +R + MT + APEV Y D++S + E++ +I Sbjct: 185 VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEI 244 Query: 262 LF 263 F Sbjct: 245 PF 246 >5M07-A nrPDB Length = 276 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 25/39 (64%), Gaps = 4/39 (10%) Query: 177 IKHLHSAGIIHRDLKPSNIVVKS----DCTLKILDFGLA 211 + + H G++HRD+ P+N+V+ S D + + DFG+A Sbjct: 145 LDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >6FAI-l nrPDB Length = 425 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 38/71 (53%), Gaps = 9/71 (12%) Query: 144 LVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----- 198 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 187 VVMELIEGYPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLED 243 Query: 199 -SDCTLKILDF 208 +DC ++DF Sbjct: 244 ENDCGFVVIDF 254 >5VDK-A nrPDB Length = 297 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 11/33 (33%), Positives = 24/33 (72%) Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 197 ++ +L Q+ G+ ++H++ ++H D+KPSNI + Sbjct: 120 KLKDILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >6J6I-B nrPDB Length = 351 Score = 33.1 bits (74), Expect = 0.30, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 78/185 (42%), Gaps = 24/185 (12%) Query: 87 DRNVAIKKLSR-PFQNQTH-AKRAYRELVL-MKCVNHKNIISLLNVFTPQKTLEEFQDVY 143 DR+ IK+ S + H K Y ++VL + NH N + LL EF Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL------EFPFPV 134 Query: 144 LVMELMDANLCQVIQMELDHERMSYLLY--------QMLCGIKHLHSAG---IIHRDLKP 192 LV E + + + S L + ++ + +LH+A IIHRD+KP Sbjct: 135 LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKP 194 Query: 193 SNIVVKSDCTLKI--LDFGLARTAGTSFMMTPYVVTRY-YRAPEVILGMGYKENVDIWSV 249 ++ + + T K+ L F ++ G S + +V+ + Y P E D++S Sbjct: 195 MHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSF 254 Query: 250 G-CIM 253 G C++ Sbjct: 255 GICLL 259 >4O1O-A nrPDB Length = 717 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 23/45 (51%) Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 E +L + I LH +G H+DL+P NI++ S + DF Sbjct: 442 ESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5TGT-A nrPDB Length = 502 Score = 31.2 bits (69), Expect = 0.95, Method: Compositional matrix adjust. Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 5/60 (8%) Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADS---EHNKLKASQARDLLSKML 340 PE++ K+ P V+ VEN + A L F P D+ EH KL +Q R +L +L Sbjct: 353 PEYLMKIAPHVQGRVENFSQIAPLA--GFFFSGGVPLDASLFEHKKLDPTQVRQVLQLVL 410 >6M7Z-A nrPDB Length = 319 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 17/75 (22%), Positives = 34/75 (45%) Query: 142 VYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC 201 Y+ L + +++ H + L M+ +K LH+ G++HR ++ ++ V D Sbjct: 122 TYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 202 TLKILDFGLARTAGT 216 T+ + A GT Sbjct: 182 TVVLGGLDTAAPIGT 196 >6DC0-A nrPDB Length = 292 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 41/202 (20%), Positives = 83/202 (41%), Gaps = 14/202 (6%) Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI ++ V + V+ + D + + L E + L Q++ + Sbjct: 56 SHSNITGIVEVILGETK----AYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 111 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTPYVVTRYYRAPEVI 235 H H + I+ DLK V ++ ++ L T G ++ Y +PE++ Sbjct: 112 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEIL 171 Query: 236 --LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC-PEFMK-KLQ 291 G + D+WS+G ++ ++ + F D ++K+ + G C PE + K + Sbjct: 172 NTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI--RRGQFCIPEHISPKAR 229 Query: 292 PTVRNYVENRPKYAGLTFPKLF 313 +R+ + P LT P++ Sbjct: 230 CLIRSLLRREPS-ERLTAPEIL 250 >4OAU-C nrPDB Length = 699 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 149 MDANLCQVIQMELDHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILD 207 +D + + ++ E D E +L + ++ LH S G H+DL+P NI++ S + D Sbjct: 425 LDVHRGEDVENEED-EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLAD 483 Query: 208 F 208 F Sbjct: 484 F 484 >5CEK-A nrPDB Length = 263 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 41/202 (20%), Positives = 83/202 (41%), Gaps = 14/202 (6%) Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI ++ V + V+ + D + + L E + L Q++ + Sbjct: 59 SHSNITGIVEVILGETK----AYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVA 114 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTPYVVTRYYRAPEVI 235 H H + I+ DLK V ++ ++ L T G ++ Y +PE++ Sbjct: 115 HCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEIL 174 Query: 236 --LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC-PEFMK-KLQ 291 G + D+WS+G ++ ++ + F D ++K+ + G C PE + K + Sbjct: 175 NTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI--RRGQFCIPEHISPKAR 232 Query: 292 PTVRNYVENRPKYAGLTFPKLF 313 +R+ + P LT P++ Sbjct: 233 CLIRSLLRREPS-ERLTAPEIL 253 >5UU1-A nrPDB Length = 324 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 34/158 (21%), Positives = 71/158 (44%), Gaps = 14/158 (8%) Query: 68 KPIGSGAQGIVCAAY-------DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 K IGSG G++ A+ DA V ++ F +R ++ + K + Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER 81 Query: 121 KNIISLLNVFTPQKTLEEFQDV---YLVMELMDANLCQVIQMELDHERMSYLLY--QMLC 175 K + L L EF+ ++VME + +L ++ ++ + L +ML Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLD 141 Query: 176 GIKHLHSAGIIHRDLKPSNIVV--KSDCTLKILDFGLA 211 ++++H +H D+K +N+++ K+ + + D+GL+ Sbjct: 142 VLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 >1TQM-A nrPDB Length = 282 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 5/65 (7%) Query: 144 LVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 ++MEL+DA +++E E + +L + + + GI+H DL N++V S+ + Sbjct: 177 VLMELIDAKELYRVRVENPDEVLDMILEE----VAKFYHRGIVHGDLSQYNVLV-SEEGI 231 Query: 204 KILDF 208 I+DF Sbjct: 232 WIIDF 236 >5ENY-A nrPDB Length = 764 Score = 28.1 bits (61), Expect = 7.5, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 114 LMKCVNHKNIISLLNVFTPQKTLE-EFQDVYLVMEL 148 ++ C+NHK ++ LN TP + E E +Y+ EL Sbjct: 530 VLLCMNHKTLVPTLNFTTPNEHFEFEHSPLYVNTEL 565 >4Q25-A nrPDB Length = 250 Score = 28.1 bits (61), Expect = 8.1, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 53/125 (42%), Gaps = 31/125 (24%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKR-------------YQNLKPIGSGAQGIVCAAYDA 84 ++SKS +D + +GD V +R Y ++ IGS Q +V A DA Sbjct: 92 SISKSVIDLE----RIGDEASKVARRAIQLCEEGESPRGYVEVRHIGSQVQKMVQEALDA 147 Query: 85 V--LDRNVAI------KKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTL 136 D ++A+ K + R + K A RELV + + I +LN+ ++L Sbjct: 148 FARFDADLALSVAQYDKTVDREY------KTALRELVTYMMEDPRAISRVLNIIWALRSL 201 Query: 137 EEFQD 141 E D Sbjct: 202 ERIGD 206 >5DMZ-A nrPDB Length = 365 Score = 28.1 bits (61), Expect = 9.6, Method: Compositional matrix adjust. Identities = 11/26 (42%), Positives = 17/26 (65%) Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVV 197 +ML I+ +H IIH D+KP N ++ Sbjct: 180 RMLYMIEQVHDCEIIHGDIKPDNFIL 205 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1JNK-A nrPDB 640 0.0 2XS0-A nrPDB 537 e-153 3FI2-A nrPDB 505 e-143 5AWM-A nrPDB 493 e-140 3E7O-A nrPDB 492 e-139 4EWQ-A nrPDB 400 e-112 1CM8-A nrPDB 391 e-109 3OHT-A nrPDB 386 e-107 4MYG-A nrPDB 381 e-106 3GC9-A nrPDB 379 e-105 5Z33-A nrPDB 368 e-102 6DTL-A nrPDB 355 3e-98 4IC8-A nrPDB 355 3e-98 4ZSG-A nrPDB 348 4e-96 4QTB-A nrPDB 347 4e-96 5NGU-A nrPDB 347 7e-96 3OZ6-A nrPDB 340 9e-94 2F9G-A nrPDB 336 1e-92 2BPM-A nrPDB 316 1e-86 4O2Z-A nrPDB 314 4e-86 4QNY-A nrPDB 314 6e-86 4NST-A nrPDB 313 1e-85 3NIZ-A nrPDB 313 1e-85 6GU6-A nrPDB 305 2e-83 5EFQ-A nrPDB 303 1e-82 4AU8-A nrPDB 297 9e-81 4CZT-A nrPDB 296 1e-80 4KRC-A nrPDB 296 1e-80 4BBM-A nrPDB 295 4e-80 5JN2-A nrPDB 294 6e-80 3RP9-A nrPDB 294 7e-80 1G3N-A nrPDB 292 2e-79 1V0B-A nrPDB 291 4e-79 3NCG-A nrPDB 290 1e-78 2W96-B nrPDB 288 4e-78 3DFA-A nrPDB 288 5e-78 3LIJ-A nrPDB 287 9e-78 3MA6-A nrPDB 285 4e-77 4BGQ-A nrPDB 284 5e-77 3N9X-A nrPDB 283 8e-77 3PG1-A nrPDB 283 1e-76 1UA2-A nrPDB 281 3e-76 4AGU-A nrPDB 281 4e-76 3MIA-A nrPDB 280 7e-76 4RGJ-A nrPDB 280 9e-76 3HZT-A nrPDB 280 1e-75 4E7W-A nrPDB 278 3e-75 3NIE-A nrPDB 278 3e-75 3DXN-A nrPDB 278 4e-75 3UTO-A nrPDB 277 6e-75 4MVF-A nrPDB 275 2e-74 1KOA-A nrPDB 275 3e-74 5ES1-A nrPDB 273 9e-74 5AIR-A nrPDB 273 1e-73 5U6Y-A nrPDB 273 1e-73 2VN9-A nrPDB 273 1e-73 2I6L-A nrPDB 273 1e-73 2VZ6-A nrPDB 273 2e-73 5IG1-A nrPDB 272 3e-73 3GC0-A nrPDB 271 4e-73 4YZB-A nrPDB 271 4e-73 5G6V-A nrPDB 270 7e-73 4D28-A nrPDB 270 1e-72 3E3P-A nrPDB 269 1e-72 5KZ7-A nrPDB 269 2e-72 2QNJ-A nrPDB 269 2e-72 5Y86-A nrPDB 269 2e-72 3ZDU-A nrPDB 268 4e-72 2V7O-A nrPDB 267 7e-72 2BDW-A nrPDB 267 8e-72 3MN3-A nrPDB 267 8e-72 5ZTN-A nrPDB 265 3e-71 4CFF-A nrPDB 265 3e-71 5FG8-A nrPDB 265 4e-71 3SOA-A nrPDB 264 5e-71 5EZV-A nrPDB 264 6e-71 3BHH-A nrPDB 264 7e-71 3KK8-A nrPDB 263 9e-71 3H4J-B nrPDB 263 1e-70 4REW-A nrPDB 263 1e-70 4RED-A nrPDB 261 5e-70 4CFH-A nrPDB 260 9e-70 3EB0-A nrPDB 260 1e-69 4FG9-A nrPDB 258 3e-69 3Q5I-A nrPDB 258 4e-69 2JC6-A nrPDB 256 2e-68 2HAK-A nrPDB 255 3e-68 6C9D-A nrPDB 254 4e-68 3COM-A nrPDB 253 1e-67 2YCR-A nrPDB 253 2e-67 3I6U-A nrPDB 253 2e-67 5WAX-A nrPDB 252 3e-67 5YKS-A nrPDB 252 3e-67 5KCV-A nrPDB 251 4e-67 3TAC-A nrPDB 251 7e-67 3D2K-A nrPDB 250 1e-66 6FD3-A nrPDB 250 1e-66 3MV5-A nrPDB 249 1e-66 4UZD-A nrPDB 249 1e-66 5XZW-A nrPDB 249 2e-66 4NIF-A nrPDB 248 3e-66 2W4O-A nrPDB 248 5e-66 2JDO-A nrPDB 247 7e-66 4LG4-A nrPDB 247 7e-66 5D9K-A nrPDB 247 1e-65 4FIE-A nrPDB 246 1e-65 2F57-A nrPDB 246 1e-65 4JDH-A nrPDB 246 1e-65 2JAM-A nrPDB 246 1e-65 6FDY-U nrPDB 246 1e-65 2Q0N-A nrPDB 246 1e-65 2WO6-A nrPDB 246 1e-65 4XBR-A nrPDB 246 2e-65 6AO5-A nrPDB 245 3e-65 4CQG-A nrPDB 244 5e-65 2J90-A nrPDB 244 6e-65 4JG6-A nrPDB 244 6e-65 2YZA-A nrPDB 244 7e-65 1KOB-A nrPDB 244 7e-65 4KS7-A nrPDB 244 8e-65 4L42-A nrPDB 243 9e-65 2Z7Q-A nrPDB 243 1e-64 4RLP-A nrPDB 243 1e-64 4D2V-A nrPDB 243 1e-64 3ZUT-A nrPDB 243 1e-64 5JZN-A nrPDB 242 3e-64 3Q53-A nrPDB 241 3e-64 3UDB-A nrPDB 241 4e-64 4PDS-A nrPDB 241 6e-64 3F3Z-A nrPDB 241 7e-64 2UV2-A nrPDB 241 7e-64 1FOT-A nrPDB 240 8e-64 3IS5-A nrPDB 240 9e-64 2YAB-A nrPDB 239 2e-63 4B6L-A nrPDB 239 2e-63 3GUB-A nrPDB 238 4e-63 3UC3-A nrPDB 238 4e-63 4I6B-A nrPDB 238 5e-63 3HDN-A nrPDB 238 6e-63 1PHK-A nrPDB 238 6e-63 2Y7J-A nrPDB 237 7e-63 4CSV-A nrPDB 237 8e-63 6O6Q-A nrPDB 237 9e-63 5X8I-B nrPDB 236 1e-62 5D7A-A nrPDB 236 1e-62 3TXO-A nrPDB 236 2e-62 4JXF-A nrPDB 235 3e-62 5F9E-A nrPDB 235 3e-62 5J5T-A nrPDB 235 4e-62 3HKO-A nrPDB 235 4e-62 3DAK-A nrPDB 235 4e-62 2A27-A nrPDB 235 4e-62 4QMW-A nrPDB 234 6e-62 1ZWS-A nrPDB 234 8e-62 4YNZ-A nrPDB 233 1e-61 2XIK-A nrPDB 233 1e-61 3DB8-A nrPDB 233 2e-61 5XVU-A nrPDB 232 3e-61 2HW6-A nrPDB 231 3e-61 5X3F-B nrPDB 231 4e-61 6FYV-A nrPDB 231 4e-61 6CMJ-A nrPDB 231 6e-61 4IAN-A nrPDB 231 6e-61 6HXF-B nrPDB 231 7e-61 5N23-A nrPDB 231 7e-61 2X4F-A nrPDB 230 1e-60 3KN6-A nrPDB 229 1e-60 4WB7-A nrPDB 229 2e-60 3NYO-A nrPDB 229 2e-60 2OU7-A nrPDB 228 4e-60 4FZF-B nrPDB 228 6e-60 2PVN-A nrPDB 228 6e-60 4J52-A nrPDB 228 6e-60 1VZO-A nrPDB 227 7e-60 6ED6-A nrPDB 227 8e-60 5DBX-A nrPDB 226 1e-59 1U5R-A nrPDB 226 1e-59 2JD5-A nrPDB 226 1e-59 1NY3-A nrPDB 226 2e-59 5YV8-A nrPDB 226 2e-59 3KA0-A nrPDB 226 2e-59 2GCD-A nrPDB 225 3e-59 2OZA-A nrPDB 225 3e-59 4EBW-A nrPDB 225 4e-59 4B8L-A nrPDB 225 4e-59 6QAU-A nrPDB 224 6e-59 4AF3-A nrPDB 224 6e-59 6E9W-A nrPDB 224 7e-59 4CRL-A nrPDB 224 7e-59 4RA4-A nrPDB 224 7e-59 3RAW-A nrPDB 224 8e-59 6CKI-A nrPDB 224 9e-59 4MD7-E nrPDB 223 1e-58 6HMD-A nrPDB 222 2e-58 3LM0-A nrPDB 222 2e-58 4APC-A nrPDB 222 2e-58 3FXW-A nrPDB 222 3e-58 3A8W-A nrPDB 222 3e-58 5LOH-A nrPDB 222 3e-58 4WNO-A nrPDB 222 3e-58 4U41-A nrPDB 221 4e-58 5KKR-C nrPDB 221 4e-58 3ORZ-A nrPDB 221 6e-58 2WTK-C nrPDB 221 8e-58 2X7G-A nrPDB 221 8e-58 4TNB-A nrPDB 220 1e-57 3EQC-A nrPDB 220 1e-57 6BDL-A nrPDB 219 1e-57 6EII-A nrPDB 219 2e-57 5DYK-A nrPDB 219 2e-57 2XYN-A nrPDB 218 3e-57 4XEY-B nrPDB 218 4e-57 5UNP-A nrPDB 218 4e-57 2FO0-A nrPDB 218 4e-57 3PPZ-A nrPDB 217 7e-57 2J0K-A nrPDB 217 1e-56 4UY9-A nrPDB 216 1e-56 6NPU-A nrPDB 216 1e-56 3PFQ-A nrPDB 216 2e-56 3TKU-A nrPDB 216 2e-56 3VN9-A nrPDB 215 3e-56 6CCF-A nrPDB 215 4e-56 2WQN-A nrPDB 214 6e-56 2I0E-A nrPDB 214 8e-56 4UYA-A nrPDB 213 1e-55 4AW2-A nrPDB 213 1e-55 6CQF-A nrPDB 213 1e-55 5FET-A nrPDB 213 2e-55 4WUA-A nrPDB 212 2e-55 6E2O-A nrPDB 212 3e-55 3DKO-A nrPDB 212 3e-55 4C0T-A nrPDB 212 3e-55 3DTC-A nrPDB 212 4e-55 4FR4-A nrPDB 211 4e-55 5L6P-A nrPDB 211 5e-55 1JPA-A nrPDB 211 5e-55 5X5O-A nrPDB 211 7e-55 5MJB-A nrPDB 211 7e-55 5H2U-A nrPDB 210 9e-55 2XNP-A nrPDB 210 1e-54 3ALO-A nrPDB 210 1e-54 4YHJ-A nrPDB 210 1e-54 4E93-A nrPDB 210 1e-54 2Y6O-A nrPDB 209 2e-54 4AN9-A nrPDB 209 2e-54 2R2P-A nrPDB 209 3e-54 3TT0-A nrPDB 209 3e-54 4P5Q-A nrPDB 209 3e-54 3C51-A nrPDB 207 5e-54 2DQ7-X nrPDB 207 5e-54 5HI2-A nrPDB 207 6e-54 2BRG-A nrPDB 207 7e-54 4GS6-A nrPDB 207 9e-54 3GQL-A nrPDB 207 1e-53 2H8H-A nrPDB 207 1e-53 6F3F-A nrPDB 206 1e-53 1S9I-A nrPDB 206 1e-53 5VO2-A nrPDB 206 1e-53 5TQX-A nrPDB 206 2e-53 6DBM-A nrPDB 206 2e-53 3A4O-X nrPDB 206 2e-53 4KIK-B nrPDB 206 2e-53 2PSQ-A nrPDB 206 2e-53 5A46-A nrPDB 205 3e-53 4OLI-A nrPDB 205 4e-53 2PL0-A nrPDB 205 4e-53 4K33-A nrPDB 205 4e-53 3QA8-A nrPDB 204 5e-53 2VWV-A nrPDB 204 5e-53 5X02-A nrPDB 204 6e-53 5EG3-A nrPDB 204 7e-53 4XCU-A nrPDB 204 8e-53 5U6B-A nrPDB 203 1e-52 4OTD-A nrPDB 203 1e-52 4AT3-A nrPDB 203 1e-52 3KUL-B nrPDB 203 1e-52 5SYS-A nrPDB 203 1e-52 4H1J-A nrPDB 203 2e-52 4XLV-A nrPDB 202 2e-52 6BXI-A nrPDB 202 2e-52 4PDO-A nrPDB 202 2e-52 5HIE-A nrPDB 202 3e-52 1TKI-A nrPDB 201 4e-52 3QUP-A nrPDB 201 6e-52 3ORP-A nrPDB 201 7e-52 2HK5-A nrPDB 201 8e-52 4EQM-A nrPDB 200 1e-51 4PWN-A nrPDB 200 1e-51 5O2B-A nrPDB 200 1e-51 4E20-A nrPDB 200 1e-51 2W1I-A nrPDB 200 1e-51 6GQK-A nrPDB 200 1e-51 3QGY-A nrPDB 199 2e-51 2OGV-A nrPDB 199 2e-51 4CRS-A nrPDB 199 2e-51 2VD5-A nrPDB 199 3e-51 5O2C-A nrPDB 199 3e-51 3V5Q-A nrPDB 199 3e-51 5B2L-A nrPDB 199 3e-51 6FEX-A nrPDB 199 3e-51 4HZS-A nrPDB 198 3e-51 3BBT-B nrPDB 198 4e-51 4LFI-A nrPDB 198 4e-51 1U54-B nrPDB 197 7e-51 4XUF-A nrPDB 197 7e-51 1FVR-A nrPDB 197 8e-51 3OMV-A nrPDB 197 1e-50 3IO7-A nrPDB 197 1e-50 1BYG-A nrPDB 197 1e-50 1AD5-A nrPDB 197 1e-50 3BEA-A nrPDB 196 1e-50 1LUF-A nrPDB 196 1e-50 1K9A-A nrPDB 196 1e-50 3ZBF-A nrPDB 196 2e-50 6BSD-A nrPDB 196 2e-50 3KRL-A nrPDB 196 2e-50 3I81-A nrPDB 196 2e-50 1ZXE-A nrPDB 196 2e-50 3FME-A nrPDB 196 3e-50 4M7I-A nrPDB 195 3e-50 3SXS-A nrPDB 195 4e-50 5UUU-A nrPDB 194 5e-50 4R7H-A nrPDB 194 5e-50 3PVW-A nrPDB 194 6e-50 4XI2-A nrPDB 194 6e-50 5KMM-A nrPDB 194 8e-50 3CJF-A nrPDB 194 1e-49 6DBN-A nrPDB 194 1e-49 4HVI-A nrPDB 193 1e-49 4Y93-A nrPDB 193 1e-49 6E4F-A nrPDB 193 1e-49 1U59-A nrPDB 193 1e-49 5HLW-A nrPDB 193 2e-49 3DLS-A nrPDB 193 2e-49 3M42-A nrPDB 193 2e-49 5AMN-A nrPDB 192 2e-49 6FER-A nrPDB 191 5e-49 3C1X-A nrPDB 191 6e-49 3PP0-A nrPDB 191 6e-49 5U6C-A nrPDB 191 6e-49 6GVJ-A nrPDB 191 7e-49 5GNK-A nrPDB 191 7e-49 5HVK-A nrPDB 191 8e-49 2OZO-A nrPDB 190 1e-48 5GRN-A nrPDB 190 1e-48 3PLS-A nrPDB 189 2e-48 3LZB-A nrPDB 189 2e-48 3HMP-A nrPDB 189 2e-48 3G0E-A nrPDB 189 3e-48 3LLT-A nrPDB 189 3e-48 4TPT-A nrPDB 188 5e-48 5AP3-A nrPDB 187 1e-47 6B2Q-A nrPDB 187 1e-47 4X3F-A nrPDB 187 1e-47 4OW8-A nrPDB 187 1e-47 5FM2-A nrPDB 187 1e-47 2A1A-B nrPDB 186 2e-47 2ZMD-A nrPDB 186 2e-47 6CTH-A nrPDB 184 5e-47 3UIU-A nrPDB 184 9e-47 4LRM-A nrPDB 183 1e-46 3BGP-A nrPDB 182 3e-46 5UIU-A nrPDB 182 3e-46 5TUR-A nrPDB 181 5e-46 5VD3-A nrPDB 181 9e-46 4FL3-A nrPDB 180 1e-45 4RC3-A nrPDB 180 1e-45 3ZZW-A nrPDB 179 2e-45 5C26-A nrPDB 177 7e-45 4NEU-A nrPDB 177 8e-45 5TOS-A nrPDB 176 3e-44 5WNO-A nrPDB 174 5e-44 5O0Y-A nrPDB 174 6e-44 4X7Q-B nrPDB 174 7e-44 4C59-A nrPDB 174 1e-43 3QD2-B nrPDB 171 7e-43 4F0G-A nrPDB 170 8e-43 5LPZ-A nrPDB 170 1e-42 5LPV-A nrPDB 170 1e-42 2RIO-A nrPDB 170 1e-42 4LQP-A nrPDB 169 2e-42 4IDT-A nrPDB 169 3e-42 4PL5-B nrPDB 168 4e-42 2PMN-X nrPDB 168 6e-42 6HV0-A nrPDB 167 6e-42 4G3E-A nrPDB 167 1e-41 3LMG-A nrPDB 165 2e-41 3HNG-A nrPDB 165 3e-41 6J5U-C nrPDB 165 4e-41 4JLC-A nrPDB 165 4e-41 2BUJ-A nrPDB 165 4e-41 3MDY-A nrPDB 164 6e-41 4Y83-A nrPDB 164 7e-41 3Q4U-A nrPDB 163 1e-40 4EUU-A nrPDB 163 1e-40 5WNL-A nrPDB 163 1e-40 4EUT-A nrPDB 162 2e-40 5TE0-A nrPDB 161 5e-40 6O8B-A nrPDB 160 8e-40 6NT9-A nrPDB 160 9e-40 3G2F-A nrPDB 160 2e-39 2QKW-B nrPDB 157 1e-38 4M66-A nrPDB 157 1e-38 2H34-A nrPDB 155 2e-38 5IKW-A nrPDB 155 3e-38 1PY5-A nrPDB 155 3e-38 3MY0-A nrPDB 155 5e-38 5XD6-A nrPDB 153 2e-37 3SOC-A nrPDB 152 3e-37 5AR8-A nrPDB 148 5e-36 2Y4I-B nrPDB 146 2e-35 2QLU-A nrPDB 145 5e-35 4BTF-A nrPDB 142 2e-34 4M69-B nrPDB 142 4e-34 5E8V-A nrPDB 142 5e-34 3VHK-A nrPDB 139 2e-33 3SV0-A nrPDB 137 7e-33 5FQD-C nrPDB 137 8e-33 4TN6-A nrPDB 136 2e-32 4BTK-A nrPDB 135 5e-32 5L2Q-C nrPDB 134 1e-31 4NFN-A nrPDB 133 1e-31 5VC6-A nrPDB 133 2e-31 5J0A-A nrPDB 132 3e-31 4RT7-A nrPDB 132 5e-31 5X1R-A nrPDB 131 6e-31 2PZI-A nrPDB 129 3e-30 4Y12-A nrPDB 129 3e-30 4JRN-A nrPDB 128 6e-30 5OAT-A nrPDB 124 1e-28 4XHH-A nrPDB 119 3e-27 4XHL-A nrPDB 118 7e-27 5CLR-A nrPDB 86 3e-17 4IX6-A nrPDB 80 2e-15 4CI6-B nrPDB 72 5e-13 Sequences not found previously or not previously below threshold: 4YFF-A nrPDB 184 6e-47 3AOX-A nrPDB 176 3e-44 2WTK-B nrPDB 163 1e-40 3UIM-A nrPDB 157 8e-39 4F9B-A nrPDB 150 1e-36 6BFN-A nrPDB 136 2e-32 4MWI-A nrPDB 135 5e-32 5VDK-A nrPDB 122 4e-28 5X18-A nrPDB 121 5e-28 2CHL-A nrPDB 120 2e-27 5CEK-A nrPDB 117 1e-26 6DC0-A nrPDB 117 1e-26 5M07-A nrPDB 115 3e-26 2C47-A nrPDB 114 7e-26 2CMW-A nrPDB 113 2e-25 4NT4-A nrPDB 113 2e-25 1CSN-A nrPDB 110 1e-24 6EQI-C nrPDB 107 1e-23 4L00-A nrPDB 105 5e-23 3REP-A nrPDB 104 7e-23 5USZ-A nrPDB 103 2e-22 4L68-A nrPDB 100 2e-21 5UV4-A nrPDB 100 3e-21 6J6I-B nrPDB 96 2e-20 5C01-A nrPDB 93 2e-19 4WOV-A nrPDB 93 2e-19 4I94-A nrPDB 87 2e-17 5UU1-A nrPDB 84 1e-16 2RSV-A nrPDB 80 1e-15 2LAV-A nrPDB 80 2e-15 6G4J-A nrPDB 74 1e-13 5DMZ-A nrPDB 74 1e-13 4O1O-A nrPDB 68 1e-11 4OAU-C nrPDB 67 2e-11 5GZA-A nrPDB 61 8e-10 6M7Z-A nrPDB 61 1e-09 3ENH-A nrPDB 60 2e-09 4AZW-A nrPDB 59 5e-09 4AZV-A nrPDB 59 6e-09 6EWX-A nrPDB 58 7e-09 2JII-A nrPDB 58 7e-09 5GZ9-A nrPDB 58 9e-09 6BHC-A nrPDB 57 1e-08 6EAS-A nrPDB 56 4e-08 6G38-A nrPDB 53 3e-07 5VE6-A nrPDB 50 2e-06 4CYJ-A nrPDB 50 2e-06 3BYV-A nrPDB 48 8e-06 3Q60-A nrPDB 47 2e-05 4WWA-A nrPDB 47 2e-05 2W1Z-A nrPDB 45 7e-05 1TQM-A nrPDB 43 2e-04 3DZO-A nrPDB 43 2e-04 4BWP-A nrPDB 43 2e-04 6G18-v nrPDB 39 0.004 6FDN-A nrPDB 38 0.006 6FAI-l nrPDB 36 0.038 4CZY-B nrPDB 35 0.078 5YK0-A nrPDB 35 0.097 4HG2-A nrPDB 35 0.098 5JNE-A nrPDB 34 0.12 4BVU-A nrPDB 34 0.14 2EHB-D nrPDB 33 0.22 4FDJ-A nrPDB 33 0.28 6EF6-A nrPDB 33 0.29 >1JNK-A nrPDB Length = 423 Score = 640 bits (1651), Expect = 0.0, Method: Composition-based stats. Identities = 423/423 (100%), Positives = 423/423 (100%) Query: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV Sbjct: 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV 60 Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY Sbjct: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 Query: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA 420 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA Sbjct: 361 VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA 420 Query: 421 VNS 423 VNS Sbjct: 421 VNS 423 >2XS0-A nrPDB Length = 386 Score = 537 bits (1384), Expect = e-153, Method: Composition-based stats. Identities = 343/379 (90%), Positives = 364/379 (96%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 +MS+SK DN FYSVE+GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA+L+RNVAIKKLSR Sbjct: 2 SMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR 61 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 157 PFQNQTHAKRAYRELVLMKCVNHKNII LLNVFTPQK+LEEFQDVY+VMELMDANLCQVI Sbjct: 62 PFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI 121 Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS 217 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS Sbjct: 122 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS 181 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 FMM P+VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM++ +LFPG D+IDQWNKVIE Sbjct: 182 FMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIE 241 Query: 278 QLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 QLGTPCPEFMKKLQPTVR YVENRPKYAG +F KLFPD LFPADSEHNKLKASQARDLLS Sbjct: 242 QLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS 301 Query: 338 KMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 KMLVID +KRISVD+ALQHPYINVWYDP+E EAPPP+I DKQLDEREHTIEEWKELIYKE Sbjct: 302 KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE 361 Query: 398 VMNSEEKTKNGVVKGQPSP 416 VM+ EE+TKNGV++GQPSP Sbjct: 362 VMDLEERTKNGVIRGQPSP 380 >3FI2-A nrPDB Length = 353 Score = 505 bits (1301), Expect = e-143, Method: Composition-based stats. Identities = 347/364 (95%), Positives = 347/364 (95%), Gaps = 11/364 (3%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 98 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP Sbjct: 1 MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP 60 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ Sbjct: 61 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 120 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF Sbjct: 121 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 180 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ Sbjct: 181 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 240 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK Sbjct: 241 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 300 Query: 339 MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEV 398 MLVIDPAKRISVDDALQHPYINVWY DEREHTIEEWKELIYKEV Sbjct: 301 MLVIDPAKRISVDDALQHPYINVWY-----------XXXXXXDEREHTIEEWKELIYKEV 349 Query: 399 MNSE 402 MNSE Sbjct: 350 MNSE 353 >5AWM-A nrPDB Length = 394 Score = 493 bits (1268), Expect = e-140, Method: Composition-based stats. Identities = 286/379 (75%), Positives = 327/379 (86%), Gaps = 3/379 (0%) Query: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 H M+ ++ +Q Y+VEVGD+ FT+ RY NL+PIGSGAQGIVCAAYD + +NVAIK Sbjct: 18 GSHRTMTTAQ--HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIK 75 Query: 94 KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANL 153 KLSRPFQN THAKRAYRE LMK VNHKNII LLN FTPQ+ LEEFQDVYLVMELMDANL Sbjct: 76 KLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANL 135 Query: 154 CQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART 213 CQVIQM+LDH+RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK+DCTLKILDFGLART Sbjct: 136 CQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART 195 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 AGT+FMMTPYVVTRYYRAPEVILGMGY ENVDIWSVGCIMGEM+R +LFPG D+IDQWN Sbjct: 196 AGTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWN 255 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPAD-SEHNKLKASQA 332 K+IEQLGTP P FM++LQPTVRNYVENRP+Y G +F +LFPD LFP D +++++ KAS A Sbjct: 256 KIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDA 315 Query: 333 RDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 R+LLSKMLVIDP +RISVD+AL+H YINVWYD EV+AP P+ YD +DEREHT+E+WKE Sbjct: 316 RNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKE 375 Query: 393 LIYKEVMNSEEKTKNGVVK 411 LIY+EVM+ E N + Sbjct: 376 LIYEEVMDYEAHNTNNRTR 394 >3E7O-A nrPDB Length = 360 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 308/359 (85%), Positives = 331/359 (92%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 S +D+QFYSV+V DSTFTVLKRYQ LKPIGSGAQGIVCAA+D VL NVA+KKLSRPFQN Sbjct: 2 SHMDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQN 61 Query: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL 161 QTHAKRAYRELVL+KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI MEL Sbjct: 62 QTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMEL 121 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA T+FMMT Sbjct: 122 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMT 181 Query: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE+V+ ++F G D+IDQWNKVIEQLGT Sbjct: 182 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGT 241 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 P EFM LQPTVRNYVENRP Y G+ F +LFPD +FP++SE +K+K SQARDLLSKMLV Sbjct: 242 PSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLV 301 Query: 342 IDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 IDP KRISVD+AL+HPYI VWYDPAE EAPPPQIYD QL+EREH IEEWKELIYKEVM+ Sbjct: 302 IDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >4EWQ-A nrPDB Length = 383 Score = 400 bits (1028), Expect = e-112, Method: Composition-based stats. Identities = 173/381 (45%), Positives = 239/381 (62%), Gaps = 19/381 (4%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87 VD+ ++ + S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D Sbjct: 11 VDLGTENLYFQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTG 70 Query: 88 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 147 VA+KKLSRPFQ+ HAKR YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV Sbjct: 71 LRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTH 130 Query: 148 LMDANLCQVIQ-MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 LM A+L +++ +L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKIL Sbjct: 131 LMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKIL 190 Query: 207 DFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPG 265 DFGLAR T MT YV TR+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG Sbjct: 191 DFGLAR--HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 248 Query: 266 RDYIDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 D+IDQ ++ +GTP E +KK+ + RNY+++ + + F +F + Sbjct: 249 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGA-------- 300 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 A DLL KMLV+D KRI+ AL H Y ++DP + P YD+ + R+ Sbjct: 301 ----NPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP--YDQSFESRD 354 Query: 385 HTIEEWKELIYKEVMNSEEKT 405 I+EWK L Y EV++ Sbjct: 355 LLIDEWKSLTYDEVISFVPPP 375 >1CM8-A nrPDB Length = 367 Score = 391 bits (1004), Expect = e-109, Method: Composition-based stats. Identities = 169/380 (44%), Positives = 242/380 (63%), Gaps = 19/380 (5%) Query: 40 SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF 99 S + FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPF Sbjct: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 Query: 100 QNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM 159 Q++ AKRAYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ Sbjct: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH 122 Query: 160 E-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 E L +R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + Sbjct: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS-- 180 Query: 219 MMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 MT YVVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 278 QLGTPCPEFMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 336 GTP EF+++LQ +NY++ P+ F + ++ + A +LL Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLL 288 Query: 337 SKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 KMLV+D +R++ +AL HPY +D + P Q YD D+ + T++EWK + YK Sbjct: 289 EKMLVLDAEQRVTAGEALAHPYFESLHDTEDE--PQVQKYDDSFDDVDRTLDEWKRVTYK 346 Query: 397 EVMNSEEKTKNGVVKGQPSP 416 EV++ + + G + +P Sbjct: 347 EVLSFKPPRQLGARVSKETP 366 >3OHT-A nrPDB Length = 389 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 169/369 (45%), Positives = 232/369 (62%), Gaps = 19/369 (5%) Query: 43 KVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ 102 K FY E+ + + V +RYQ L P+GSGA G VC++YD +A+KKLSRPFQ+ Sbjct: 32 KERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSI 91 Query: 103 THAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MEL 161 HAKR YREL L+K + H+N+I LL+VFTP +LEEF DVYLV LM A+L +++ +L Sbjct: 92 IHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKL 151 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT Sbjct: 152 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMT 209 Query: 222 PYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 YV TR+YRAPE++L M Y VDIWSVGCIM E++ + LFPG D+I+Q +++ G Sbjct: 210 GYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 269 Query: 281 TPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 TP + ++ RNY+ + P+ F +F + A DLL KM Sbjct: 270 TPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGA------------NPLAVDLLEKM 317 Query: 340 LVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM 399 LV+D KRI+ +AL HPY + ++DP + P + YD+ + R+ IEEWK L Y+EV Sbjct: 318 LVLDTDKRITASEALAHPYFSQYHDPDDE--PESEPYDQSFESRQLEIEEWKRLTYEEVC 375 Query: 400 NSEEKTKNG 408 + E +G Sbjct: 376 SFETPPFDG 384 >4MYG-A nrPDB Length = 372 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 169/358 (47%), Positives = 231/358 (64%), Gaps = 17/358 (4%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY +V + + + K Y + +GSGA G VC+A D VAIKKLSRPFQ++ AKR Sbjct: 29 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 88 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMS 167 AYREL+L+K + H+N+I LL+VFTP +L F D YLVM M +L +++ ME E++ Sbjct: 89 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQ 148 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 YL+YQML G+K++HSAG++HRDLKP N+ V DC LKILDFGLAR A MT YVVTR Sbjct: 149 YLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADA--EMTGYVVTR 206 Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G+DY+DQ ++++ G P EF Sbjct: 207 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 266 Query: 287 MKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++KL ++Y+++ P+ F +LFP + + QA DLL KML +D Sbjct: 267 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA------------SPQAADLLEKMLELDVD 314 Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEE 403 KR++ AL HP+ + DP E E Q +D L+ + T++EWK+ IYKE++N Sbjct: 315 KRLTAAQALTHPFFEPFRDPEE-ETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >3GC9-A nrPDB Length = 370 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 168/357 (47%), Positives = 237/357 (66%), Gaps = 19/357 (5%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 FY E+ + + V +R Q L+P+GSGA G VC+AYDA L + VA+KKLSRPFQ+ HA+R Sbjct: 14 FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 73 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 YREL L+K + H+N+I LL+VFTP ++E+F +VYLV LM A+L +++ + L E + Sbjct: 74 TYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHV 133 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 +L+YQ+L G+K++HSAGIIHRDLKPSN+ V D L+ILDFGLAR A MT YV T Sbjct: 134 QFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADE--EMTGYVAT 191 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 R+YRAPE++L M Y + VDIWSVGCIM E+++ K LFPG DYIDQ +++E +GTP PE Sbjct: 192 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPE 251 Query: 286 FMKKLQPT-VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + K+ R Y+++ P +F + A DLL +MLV+D Sbjct: 252 VLAKISSEHARTYIQSLPPMPQKDLSSIFRGA------------NPLAIDLLGRMLVLDS 299 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNS 401 +R+S +AL H Y + ++DP + P YD+ ++ +E T+EEWKEL Y+EV++ Sbjct: 300 DQRVSAAEALAHAYFSQYHDPEDEPEAEP--YDESVEAKERTLEEWKELTYQEVLSF 354 >5Z33-A nrPDB Length = 425 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 146/402 (36%), Positives = 220/402 (54%), Gaps = 33/402 (8%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 +V + F V +RY K +G GA GIVCAA + VAIKK++ F + AKRA RE Sbjct: 21 KVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALRE 80 Query: 112 LVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMSY 168 + L++ H+NI L ++ P+ + F + YL ELM+ +L +I+ L Sbjct: 81 IKLLQHFRGHRNITCLYDMDIPRP--DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQS 138 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM-----MTPY 223 +YQ+LCG+K++HSA ++HRDLKP N++V +DC LKI DFGLAR MT Y Sbjct: 139 FIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEY 198 Query: 224 VVTRYYRAPEV-ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 V TR+YRAPE+ + Y + +D+WSVGCI+ E++ + F GRDY+DQ N+++ LGTP Sbjct: 199 VATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTP 258 Query: 283 CPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 E + ++ P + YV N P A FP LFP++ A DLL +ML Sbjct: 259 NEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNA------------NPDALDLLDRMLA 306 Query: 342 IDPAKRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 DP+ RISV+ AL+HPY+++W+D E + P +D ++ E + E +++I EV Sbjct: 307 FDPSSRISVEQALEHPYLHIWHDASDEPDCPTTFNFDFEVVE---DVGEMRKMILDEVYR 363 Query: 401 SEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTD 442 + +V+ P G + +P + + D Sbjct: 364 FRQ-----LVRTAPGAGGHGAPHAPQVPIPAGAGQGQWKAED 400 >6DTL-A nrPDB Length = 364 Score = 355 bits (910), Expect = 3e-98, Method: Composition-based stats. Identities = 144/367 (39%), Positives = 214/367 (58%), Gaps = 20/367 (5%) Query: 45 DNQFYSVEVGDSTFTVLKRYQN-LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103 +F + + F V +Y+ + PIG GA GIVC+A ++ + +VAIKK++ F N+ Sbjct: 12 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 71 Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--L 161 AKR RE+ L++ ++H+NI+++ ++ P F DVY+ ELMD +L Q+I+ L Sbjct: 72 DAKRTLREIKLLRHMDHENIVAIRDII-PPPLRNAFNDVYIAYELMDTDLHQIIRSNQAL 130 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 E Y LYQ+L G+K++HSA ++HRDLKPSN+++ ++C LKI DFGLAR S MT Sbjct: 131 SEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMT 190 Query: 222 PYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 YVVTR+YRAPE++L Y +D+WSVGCI E++ K LFPGRD++ Q ++E +G Sbjct: 191 EYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIG 250 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 TP E ++ L + Y+ P Y + FP A DL+ KML Sbjct: 251 TPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPT------------VHPLAIDLIEKML 298 Query: 341 VIDPAKRISVDDALQHPYINVWYD-PAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM 399 DP +RI+V DAL HPY+N +D E E P +D + + E+ KELIY+E + Sbjct: 299 TFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFD--FENHALSEEQMKELIYREAL 356 Query: 400 NSEEKTK 406 + + Sbjct: 357 AFNPEYQ 363 >4IC8-A nrPDB Length = 442 Score = 355 bits (910), Expect = 3e-98, Method: Composition-based stats. Identities = 143/383 (37%), Positives = 219/383 (57%), Gaps = 22/383 (5%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL + Sbjct: 48 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI 107 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMSYLLYQ 172 +K H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 167 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTR 227 +L G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR Sbjct: 168 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATR 227 Query: 228 YYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P Sbjct: 228 WYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAV 287 Query: 287 MKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 ++ + VR Y+++ P + + ++P + QA LL +ML +P+ Sbjct: 288 IQAVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPS 335 Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKT 405 RIS AL+HP++ ++DP + P +D D T E KE I E+ + + Sbjct: 336 ARISAAAALRHPFLAKYHDPDDEPDCAPP-FDFAFDREALTRERIKEAIVAEIEDFHARR 394 Query: 406 KNGVVKGQPSPSGAAVNSSESLP 428 + + + PS V S P Sbjct: 395 EGIRQQIRFQPSLQPVASEPGCP 417 >4ZSG-A nrPDB Length = 347 Score = 348 bits (892), Expect = 4e-96, Method: Composition-based stats. Identities = 137/359 (38%), Positives = 211/359 (58%), Gaps = 22/359 (6%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 TF V Y+ ++ IG+GA G+V +A + + VAIKK+ F T+AKR REL ++K Sbjct: 2 TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 61 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMSYLLYQML 174 H NII++ ++ P EF+ VY+V++LM+++L Q+I L E + Y LYQ+L Sbjct: 62 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-----FMMTPYVVTRYY 229 G+K++HSA +IHRDLKPSN++V +C LKI DFG+AR TS + MT YV TR+Y Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 230 RAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 RAPE++L + Y + +D+WSVGCI GEM+ + LFPG++Y+ Q ++ LGTP P ++ Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 289 KLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 + VR Y+++ P + + ++P + QA LL +ML +P+ R Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGA------------DRQALSLLGRMLRFEPSAR 289 Query: 348 ISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTK 406 IS AL+HP++ ++DP + P +D D T E KE I E+ + + + Sbjct: 290 ISAAAALRHPFLAKYHDPDDEPDCAPP-FDFAFDREALTRERIKEAIVAEIEDFHARRE 347 >4QTB-A nrPDB Length = 380 Score = 347 bits (891), Expect = 4e-96, Method: Composition-based stats. Identities = 145/360 (40%), Positives = 222/360 (61%), Gaps = 24/360 (6%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 V F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ Sbjct: 32 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 90 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171 ++ H+N+I + ++ TLE +DVY+V +LM+ +L ++++ + L ++ + Y LY Sbjct: 91 QILLRFRHENVIGIRDI-LRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 149 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 150 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 228 YYRAPEV-ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE+ + GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 210 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 269 Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + + RNY+++ P + + KLFP S S+A DLL +ML +P Sbjct: 270 LNCIINMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPN 317 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 KRI+V++AL HPY+ +YDP E A P + +LD+ E KELI++E + Sbjct: 318 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQPG 375 >5NGU-A nrPDB Length = 381 Score = 347 bits (890), Expect = 7e-96, Method: Composition-based stats. Identities = 146/363 (40%), Positives = 225/363 (61%), Gaps = 24/363 (6%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 V F V RY NL IG GA G+VC+AYD + VAIKK+S PF++QT+ +R RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREI 91 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLY 171 ++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ L ++ + Y LY Sbjct: 92 KILLRFRHENIIGINDII-RAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227 Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 228 YYRAPEV-ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YRAPE+ + GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + + RNY+ + P + + +LFP++ S+A DLL KML +P Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 318 Query: 346 KRISVDDALQHPYINVWYDP-AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 KRI V+ AL HPY+ +YDP E A P +D +LD+ E+ KELI++E + Sbjct: 319 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQPG 376 Query: 405 TKN 407 ++ Sbjct: 377 YRS 379 >3OZ6-A nrPDB Length = 388 Score = 340 bits (871), Expect = 9e-94, Method: Composition-based stats. Identities = 126/385 (32%), Positives = 212/385 (55%), Gaps = 40/385 (10%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV 113 G VL++Y+ +K +G GA GIV + D VA+KK+ FQN T A+R +RE++ Sbjct: 1 GRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIM 60 Query: 114 LMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171 ++ ++ H+NI++LLNV + +DVYLV + M+ +L VI+ L+ Y++Y Sbjct: 61 ILTELSGHENIVNLLNVLR----ADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVY 116 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA----------------- 214 Q++ IK+LHS G++HRD+KPSNI++ ++C +K+ DFGL+R+ Sbjct: 117 QLIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINEN 176 Query: 215 -----GTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDY 268 ++T YV TR+YRAPE++LG Y + +D+WS+GCI+GE++ K +FPG Sbjct: 177 TENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSST 236 Query: 269 IDQWNKVIEQLGTPCPE--------FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA 320 ++Q ++I + P E F K + +++ VE R F K Sbjct: 237 MNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTK---WKNLLL 293 Query: 321 DSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQL 380 +A DLL K+L +P KRIS +DAL+HP+++++++P E I Sbjct: 294 KINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPIN 353 Query: 381 DEREHTIEEWKELIYKEVMNSEEKT 405 D +H+I++++ L+Y E+ + + Sbjct: 354 DNVKHSIDDYRNLVYSEISRRKREL 378 >2F9G-A nrPDB Length = 353 Score = 336 bits (862), Expect = 1e-92, Method: Composition-based stats. Identities = 129/361 (35%), Positives = 195/361 (54%), Gaps = 32/361 (8%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 + + +Q +G GA G+VC+A VAIKK+ PF A R RE+ ++K Sbjct: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKH 65 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 176 H+NII++ N+ + E F +VY++ ELM +L +VI + L + + Y +YQ L Sbjct: 66 FKHENIITIFNI-QRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM-----------MTPYVV 225 +K LH + +IHRDLKPSN+++ S+C LK+ DFGLAR S MT YV Sbjct: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 226 TRYYRAPEV-ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP-C 283 TR+YRAPEV + Y +D+WS GCI+ E+ + +FPGRDY Q + +GTP Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Query: 284 PEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 ++ + P R Y+++ P Y K+FP + DLL +MLV Sbjct: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR------------VNPKGIDLLQRMLVF 292 Query: 343 DPAKRISVDDALQHPYINVWYDP---AEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM 399 DPAKRI+ +AL+HPY+ ++DP E E PP ++ + T ++ K+LI+ E+ Sbjct: 293 DPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIF 352 Query: 400 N 400 + Sbjct: 353 S 353 >2BPM-A nrPDB Length = 309 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 107/311 (34%), Positives = 160/311 (51%), Gaps = 25/311 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ +Q ++ IG G G+V A + + VA+KK+ + + A RE+ L+K +NH Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCG 176 NI+ LL+V + +YLV E + +L + + + + L+Q+L G Sbjct: 66 PNIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQG 119 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVI 235 + HS ++HRDLKP N+++ ++ +K+ DFGLAR G T VVT +YRAPE++ Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 236 LGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 LG Y VDIWS+GCI EMV + LFPG IDQ ++ LGTP + ++ Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVT-SM 238 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 +Y + PK+A F K+ P R LLS+ML DP KRIS AL Sbjct: 239 PDYKPSFPKWARQDFSKVVP------------PLDEDGRSLLSQMLHYDPNKRISAKAAL 286 Query: 355 QHPYINVWYDP 365 HP+ P Sbjct: 287 AHPFFQDVTKP 297 >4O2Z-A nrPDB Length = 377 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 126/377 (33%), Positives = 195/377 (51%), Gaps = 19/377 (5%) Query: 32 YIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVA 91 Y + +S K+ F V S F V +Y LK +G GA GI C+ D V+ Sbjct: 15 YFQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVS 74 Query: 92 IKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTP-QKTLEEFQDVYLVMELMD 150 IKK F++ KR RE+ +M+ +H+N+++++N+ P ++ F+DVY+V LMD Sbjct: 75 IKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD 134 Query: 151 ANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 ++ V++ L+ M Y +YQ+L G+K+LHSA + HRDLKP+N+V C LKI+DF Sbjct: 135 VDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDF 194 Query: 209 GLARTAG-TSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGR 266 GL+R+ +T YV+TR+YR PE++L Y VDIWSVGCI EM K +FPGR Sbjct: 195 GLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGR 254 Query: 267 DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNK 326 + +DQ + + +G P ++ + P L PKL P Sbjct: 255 NTMDQLRMIAQHIGKPPASIVE--HREALEKLNELPD-GSLNIPKLVP----------GL 301 Query: 327 LKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHT 386 ++ D LSKM +DP+KR + D L HPY+ +D E E P + + Sbjct: 302 AGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD-EEDEPTCPCPFLWAHESTPMG 360 Query: 387 IEEWKELIYKEVMNSEE 403 + E + + ++++ Sbjct: 361 VSELRRAFWADIVDYNP 377 >4QNY-A nrPDB Length = 354 Score = 314 bits (804), Expect = 6e-86, Method: Composition-based stats. Identities = 116/351 (33%), Positives = 196/351 (55%), Gaps = 24/351 (6%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTH-AKRAYRELVLMKC 117 + RY + IG+G+ G+V A D +R VA+K++++ + AKR RE+ L+ Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMSYLLYQMLC 175 N NII L N+ TP+ E F Y+VM++M+ +L QV++ EL + + +YQ L Sbjct: 78 FNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-SFMMTPYVVTRYYRAPE- 233 + +HSAG+IHRD+ P+NI+V ++C LKI DFGLA+ MT YV R+YRAPE Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y +D+W +GCI+GE++ + LF G+D ++Q +K+++ +GTP E + + + Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 294 -VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 + Y++ + + + +P + + +A DLL MLV +P +RI+V Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTA------------SPEALDLLRHMLVFNPKRRITVLQ 304 Query: 353 ALQHPYINVWYDPAEVEAPPP-QIYDKQLDEREHTIEEWKELIYKEVMNSE 402 A++HP++ +D A+ +D + + TI + K IY+E + Sbjct: 305 AMRHPFLEQLHDDADDNLSYALFRFD---ENEQKTIVDVKRAIYEESVKFH 352 >4NST-A nrPDB Length = 351 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 96/367 (26%), Positives = 168/367 (45%), Gaps = 37/367 (10%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + ++ + IG G G V A D VA+KK+ + + A RE+ +++ + H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 121 KNIISLLNVFTPQKTLEEFQD----VYLVMELMDANLCQVIQM---ELDHERMSYLLYQM 173 ++++++ + T ++ +F+ YLV E MD +L +++ + + + Q+ Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG--TSFMMTPYVVTRYYRA 231 + G+++ H +HRD+K SNI++ + +K+ DFGLAR S T V+T +YR Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 191 Query: 232 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PE++LG Y +D+WS GCI+GE+ K +F + Q + G+PCP Sbjct: 192 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCP------ 245 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 V V P + + K + L E S A DLL ML +DP+KR + Sbjct: 246 --AVWPDVIKLPYFNTMKPKKQYRRRL----REEFSFIPSAALDLLDHMLTLDPSKRCTA 299 Query: 351 DDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVV 410 + LQ ++ D + PP + W++ + ++GVV Sbjct: 300 EQTLQSDFLK---DVELSKMAPPD------------LPHWQDCHELWSKKRRRQRQSGVV 344 Query: 411 KGQPSPS 417 +P PS Sbjct: 345 VEEPPPS 351 >3NIZ-A nrPDB Length = 311 Score = 313 bits (801), Expect = 1e-85, Method: Composition-based stats. Identities = 111/310 (35%), Positives = 163/310 (52%), Gaps = 24/310 (7%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++++YQ L+ +G G G+V A D+ R VA+K++ +++ A RE+ L+K ++ Sbjct: 19 LMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELH 77 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCG 176 H NI+SL++V ++ L LV E M+ +L +V+ + L ++ LYQ+L G Sbjct: 78 HPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRG 131 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVI 235 + H H I+HRDLKP N+++ SD LK+ DFGLAR G T VVT +YRAP+V+ Sbjct: 132 VAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVL 191 Query: 236 LG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 +G Y +VDIWS+GCI EM+ K LFPG DQ K+ LGTP P ++Q Sbjct: 192 MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELP 251 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 + + + P + DLLS ML DP KRIS DA+ Sbjct: 252 LWKQRTFQVFEKKPWSSIIPGFC------------QEGIDLLSNMLCFDPNKRISARDAM 299 Query: 355 QHPYINVWYD 364 HPY Sbjct: 300 NHPYFKDLDP 309 >6GU6-A nrPDB Length = 302 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 113/311 (36%), Positives = 161/311 (51%), Gaps = 26/311 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM-----ELDHERMSYLLYQMLC 175 NI+SL +V L + +YL+ E + +L + + +D + LYQ+L Sbjct: 66 PNIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 119 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEV 234 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV Sbjct: 120 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 179 Query: 235 ILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 +LG Y VDIWS+G I E+ K LF G IDQ ++ LGTP E ++ + Sbjct: 180 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV-ES 238 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 +++Y TFPK P SL H K DLLSKML+ DPAKRIS A Sbjct: 239 LQDYKN--------TFPKWKPGSLAS----HVKNLDENGLDLLSKMLIYDPAKRISGKMA 286 Query: 354 LQHPYINVWYD 364 L HPY N + Sbjct: 287 LNHPYFNDLDN 297 >5EFQ-A nrPDB Length = 347 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 164/360 (45%), Gaps = 37/360 (10%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + ++ + IG G G V A D VA+KK+ + + A RE+ +++ + H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 121 KNIISLLNVFTPQKTLEEFQD----VYLVMELMDANLCQVIQM---ELDHERMSYLLYQM 173 ++II++ + T ++ +F+ YLV E MD +L +++ + + + Q+ Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 129 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--TAGTSFMMTPYVVTRYYRA 231 + G+ + H +HRD+K SNI++ + +K+ DFGLAR ++ S T V+T +YR Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 189 Query: 232 PEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PE++LG Y +D+WS GCI+GE+ K +F + Q + G+PCP Sbjct: 190 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCP------ 243 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 V V P + + K + L E + A DL ML +DP+KR + Sbjct: 244 --AVWPDVIKLPYFNTMKPKKQYRRKL----REEFVFIPAAALDLFDYMLALDPSKRCTA 297 Query: 351 DDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVV 410 + ALQ ++ D + PPP + W++ + + G+ Sbjct: 298 EQALQCEFLR---DVEPSKMPPPDLPL------------WQDCHELWSKKRRRQKQMGMT 342 >4AU8-A nrPDB Length = 296 Score = 297 bits (760), Expect = 9e-81, Method: Composition-based stats. Identities = 102/313 (32%), Positives = 154/313 (49%), Gaps = 31/313 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++Y+ L+ IG G G V A + VA+K++ ++ A RE+ L+K + HK Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGIK 178 NI+ L +V K L LV E D +L + +LD E + L+Q+L G+ Sbjct: 66 NIVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG 119 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVILG 237 HS ++HRDLKP N+++ + LK+ DFGLAR G + VVT +YR P+V+ G Sbjct: 120 FCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFG 179 Query: 238 MG-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y ++D+WS GCI E+ + LFPG D DQ ++ LGTP E + Sbjct: 180 AKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK--- 236 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEH---NKLKASQARDLLSKMLVIDPAKRISVDD 352 P P ++PA + + RDLL +L +P +RIS ++ Sbjct: 237 -------------LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE 283 Query: 353 ALQHPYINVWYDP 365 ALQHPY + + P Sbjct: 284 ALQHPYFSDFCPP 296 >4CZT-A nrPDB Length = 464 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 90/426 (21%), Positives = 162/426 (38%), Gaps = 83/426 (19%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVL 114 S T + +Y+ + +G G V A + NVAIK + + + RE+ Sbjct: 5 SGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST 64 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLY 171 MK + H N+I + V + +Y V+E + L I L + Sbjct: 65 MKLIKHPNVIRMFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQ 118 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA---RTAGTSFMMTPYVVTRY 228 Q++ + + HS G+ HRDLKP N+++ ++ LK+ DFGL+ + ++ T Sbjct: 119 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 178 Query: 229 YRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y APEVI GY D+WS G I+ ++ + F + + K+ + T P F Sbjct: 179 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFS 238 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 + ++ ++ P A R Sbjct: 239 ASAKKLIKRILDPNP------------------------------------------ATR 256 Query: 348 ISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKN 407 I+ + +++ + Y +AP + D LD+ + ++ E V EE K Sbjct: 257 ITFAEVIENEWFKKGY-----KAPKFENADVSLDDVDAIFDDSGESKNLVVERREEGLKT 311 Query: 408 GVVKGQPSPSGAAVNSSESLPPSSSVNDIS------------SMSTDQTLASDTDSSLEA 455 V +N+ E + S +N S + T ++ A++ + +EA Sbjct: 312 PVT----------MNAFELISTSQGLNLGSLFEKQMGLVKRKTRFTSKSSANEIVTKIEA 361 Query: 456 SAGPLG 461 +A P+G Sbjct: 362 AAAPMG 367 >4KRC-A nrPDB Length = 317 Score = 296 bits (758), Expect = 1e-80, Method: Composition-based stats. Identities = 93/316 (29%), Positives = 149/316 (47%), Gaps = 25/316 (7%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 +++ L+ +G+G V + VA+K++ + + A RE+ LMK + H+N Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHEN 64 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--------LDHERMSYLLYQML 174 I+ L +V + L LV E MD +L + + L+ + Y +Q+L Sbjct: 65 IVRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPE 233 G+ H I+HRDLKP N+++ LK+ DFGLAR G + VVT +YRAP+ Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPD 178 Query: 234 VILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 V++G Y ++DIWS GCI+ EM+ K LFPG + +Q + + +GTP Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP--------NE 230 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 ++ V PKY + D + D L +L ++P R+S Sbjct: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Query: 353 ALQHPYINVWYDPAEV 368 AL HP+ +Y A + Sbjct: 291 ALHHPWFAEYYHHASM 306 >4BBM-A nrPDB Length = 331 Score = 295 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 101/329 (30%), Positives = 158/329 (48%), Gaps = 24/329 (7%) Query: 50 SVEVGDST--FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 V++G F +++Y+NL +G G+ G+V + R VAIKK ++ K Sbjct: 11 GVDLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKI 70 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHE 164 A RE+ L+K + H+N+++LL V +K YLV E +D + ++ LD++ Sbjct: 71 AMREIKLLKQLRHENLVNLLEVCKKKKRW------YLVFEFVDHTILDDLELFPNGLDYQ 124 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPY 223 + L+Q++ GI HS IIHRD+KP NI+V +K+ DFG ART + Sbjct: 125 VVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDE 184 Query: 224 VVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 V TR+YRAPE+++G Y + VD+W++GC++ EM + LFPG IDQ ++ LG Sbjct: 185 VATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG-- 242 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 L P + P +AG+ P++ + DL K L I Sbjct: 243 ------NLIPRHQELFNKNPVFAGVRLPEIKEREPL---ERRYPKLSEVVIDLAKKCLHI 293 Query: 343 DPAKRISVDDALQHPYINVWYDPAEVEAP 371 DP KR + L H + + Sbjct: 294 DPDKRPFCAELLHHDFFQMDGFAERFSQE 322 >5JN2-A nrPDB Length = 525 Score = 294 bits (752), Expect = 6e-80, Method: Composition-based stats. Identities = 93/336 (27%), Positives = 148/336 (44%), Gaps = 47/336 (13%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ-THAKRAYRE 111 V ST RY+ + +G G+ G V D + + A+K +S+ Q T + RE Sbjct: 58 VQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLRE 117 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY 171 + L+K ++H NI+ L F + +VY EL D + + + ++ Sbjct: 118 VQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIIS---RKRFSEVDAARIIR 174 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRY 228 Q+L GI ++H I+HRDLKP N++++S D ++I+DFGL+ S M + T Y Sbjct: 175 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY 234 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y APEV+ G Y E D+WS G I+ ++ F G + D KV + Sbjct: 235 YIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG---------- 283 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 Y P++ K + A+DL+ KML P+ RI Sbjct: 284 -------KYTFELPQW---------------------KKVSESAKDLIRKMLTYVPSMRI 315 Query: 349 SVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 S DAL H +I Y ++ P + + L+ R+ Sbjct: 316 SARDALDHEWIQT-YTKEQISVDVPSLDNAILNIRQ 350 >3RP9-A nrPDB Length = 458 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 125/443 (28%), Positives = 204/443 (46%), Gaps = 81/443 (18%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 K ++ SK S+ S + + RY+ IG+G+ G VC AYD + R V Sbjct: 27 GQQRKQHHSSKPTA-----SMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVV 81 Query: 91 AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD 150 AIKK+ R F++ KR RE+ ++ +NH +++ +L++ P+ +E+F ++Y+V+E+ D Sbjct: 82 AIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKD-VEKFDELYVVLEIAD 140 Query: 151 ANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 ++ ++ + L + LLY +L G+K++HSAGI+HRDLKP+N +V DC++K+ DF Sbjct: 141 SDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDF 200 Query: 209 GLARTAGTSF----------------------------MMTPYVVTRYYRAPE-VILGMG 239 GLART +T +VVTR+YRAPE ++L Sbjct: 201 GLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQEN 260 Query: 240 YKENVDIWSVGCIMGEMVR-----------HKILFPG--------------------RDY 268 Y E +D+WS+GCI E++ LFPG R Sbjct: 261 YTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGN 320 Query: 269 IDQWNKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKL 327 DQ N + LGTP E ++ L + + Y+ PK G + FP S Sbjct: 321 RDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPAS----------- 369 Query: 328 KASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTI 387 ++ A LL +MLV +P KRI++++ L HP+ ++ D Sbjct: 370 -SADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDE 428 Query: 388 EEWKELIYKEVMNSEEKTKNGVV 410 + + KE+ + + Sbjct: 429 PQLRYAFVKEIQRYHPEIQLPRR 451 >1G3N-A nrPDB Length = 326 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 104/309 (33%), Positives = 151/309 (48%), Gaps = 24/309 (7%) Query: 62 KRYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN- 119 ++Y+ + IG GA G V A D R VA+K++ + RE+ +++ + Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 120 --HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQM 173 H N++ L +V T +T E + LV E +D +L + + + E + +++Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRE-TKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 L G+ LHS ++HRDLKP NI+V S +K+ DFGLAR +T VVT +YRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+L Y VD+WSVGCI EM R K LF G +DQ K+++ +G P E Sbjct: 190 VLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW------ 243 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 P+ L S P + +DLL K L +PAKRIS A Sbjct: 244 --------PRDVALPRQAFHSKSAQPIEK-FVTDIDELGKDLLLKCLTFNPAKRISAYSA 294 Query: 354 LQHPYINVW 362 L HPY Sbjct: 295 LSHPYFQDL 303 >1V0B-A nrPDB Length = 288 Score = 291 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 102/306 (33%), Positives = 150/306 (49%), Gaps = 25/306 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +++Y L+ IG G G+V A + A+KK+ +++ RE+ ++K + H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCGI 177 NI+ L +V +K L LV E +D +L +++ + L+ L Q+L GI Sbjct: 60 SNIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGI 113 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVIL 236 + H ++HRDLKP N+++ + LKI DFGLAR G T VVT +YRAP+V++ Sbjct: 114 AYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLM 173 Query: 237 G-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y +DIWSVGCI EMV LFPG DQ ++ LGTP + + + Sbjct: 174 GSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTE-LP 232 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 Y N Y L + K DLLSKML +DP +RI+ AL+ Sbjct: 233 KYDPNFTVYEPLPWESFL------------KGLDESGIDLLSKMLKLDPNQRITAKQALE 280 Query: 356 HPYINV 361 H Y Sbjct: 281 HAYFKE 286 >3NCG-A nrPDB Length = 486 Score = 290 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 81/334 (24%), Positives = 140/334 (41%), Gaps = 45/334 (13%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T +RY + +G G+ G V D + + A+K +++ RE+ L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI+ L + + ++Y EL D + + + ++ Q+ GI Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIK---RKRFSEHDAARIIKQVFSGIT 135 Query: 179 HLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 ++H I+HRDLKP NI+++S DC +KI+DFGL+ + M + T YY APEV+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y E D+WS G I+ ++ F G++ D +V Sbjct: 196 RGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-------------------- 234 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 + D + + A+DL+ KML P+ RI+ L+ Sbjct: 235 ------------------ETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLE 276 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 HP+I + + P + + R+ E+ Sbjct: 277 HPWIQKYSSETPTISDLPSLESAMTNIRQFQAEK 310 >2W96-B nrPDB Length = 306 Score = 288 bits (737), Expect = 4e-78, Method: Composition-based stats. Identities = 110/312 (35%), Positives = 153/312 (49%), Gaps = 23/312 (7%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN--- 119 RY+ + IG GA G V A D VA+K + P + RE+ L++ + Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLC 175 H N++ L++V +T E + V LV E +D +L + L E + L+ Q L Sbjct: 65 HPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 123 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR + P VVT +YRAPEV+ Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVL 183 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 L Y VD+WSVGCI EM R K LF G DQ K+ + +G P + Sbjct: 184 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-------- 235 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 P+ L P P S +++ S A+ LL +ML +P KRIS ALQ Sbjct: 236 ------PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFRALQ 288 Query: 356 HPYINVWYDPAE 367 H Y++ E Sbjct: 289 HSYLHKDEGNPE 300 >3DFA-A nrPDB Length = 286 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 132/307 (42%), Gaps = 45/307 (14%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T +RY + +G G+ G V D + + A+K +++ RE+ L+K + Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI+ L + + ++Y EL D + + + ++ Q+ GI Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIK---RKRFSEHDAARIIKQVFSGIT 135 Query: 179 HLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 ++H I+HRDLKP NI+++S DC +KI+DFGL+ + M + T YY APEV+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y E D+WS G I+ ++ F G++ D +V Sbjct: 196 RGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV-------------------- 234 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 + D + + A+DL+ KML P+ RI+ L+ Sbjct: 235 ------------------ETGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLE 276 Query: 356 HPYINVW 362 HP+I + Sbjct: 277 HPWIQKY 283 >3LIJ-A nrPDB Length = 494 Score = 287 bits (734), Expect = 9e-78, Method: Composition-based stats. Identities = 91/360 (25%), Positives = 153/360 (42%), Gaps = 55/360 (15%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 ++ F + + G + + YQ +K +GSGA G V D V Sbjct: 10 GRENLYFQGDLQATPGMFITSKKG----HLSEMYQRVKKLGSGAYGEVLLCRDKVTHVER 65 Query: 91 AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME-LM 149 AIK + + + + + E+ ++K ++H NI+ L + F ++ + YLVME Sbjct: 66 AIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKR------NYYLVMECYK 119 Query: 150 DANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLK 204 L I +M+ + + ++ Q+L G+ +LH I+HRDLKP N++++S D +K Sbjct: 120 GGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIK 179 Query: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 I+DFGL+ M + T YY APEV+ Y E D+WS+G I+ ++ F Sbjct: 180 IVDFGLSAVFENQKKMKERLGTAYYIAPEVLR-KKYDEKCDVWSIGVILFILLAGYPPFG 238 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 G+ + KV + + DS Sbjct: 239 GQTDQEILRKVEK--------------------------------------GKYTFDSPE 260 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 K + A+DL+ +ML D +RIS AL+HP+I E P + + + R+ Sbjct: 261 WKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLANAIENMRK 320 >3MA6-A nrPDB Length = 298 Score = 285 bits (728), Expect = 4e-77, Method: Composition-based stats. Identities = 90/325 (27%), Positives = 143/325 (44%), Gaps = 49/325 (15%) Query: 45 DNQFYSVE---VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 +N ++ V ST RY+ + +G G+ G V D + + A+K +S+ Sbjct: 12 ENLYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVK 71 Query: 102 Q-THAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME 160 Q T + RE+ L+K ++H NI+ L F + +VY EL D + + Sbjct: 72 QKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIIS---RKR 128 Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTS 217 + ++ Q+L GI ++H I+HRDLKP N++++S D ++I+DFGL+ S Sbjct: 129 FSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEAS 188 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 M + T YY APEV+ G Y E D+WS G I+ ++ F G + D KV + Sbjct: 189 KKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK 247 Query: 278 QLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 Y P++ K + A+DL+ Sbjct: 248 G-----------------KYTFELPQW---------------------KKVSESAKDLIR 269 Query: 338 KMLVIDPAKRISVDDALQHPYINVW 362 KML P+ RIS DAL H +I + Sbjct: 270 KMLTYVPSMRISARDALDHEWIQTY 294 >4BGQ-A nrPDB Length = 304 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 94/307 (30%), Positives = 155/307 (50%), Gaps = 21/307 (6%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 V+ +++ L +G GA G+V VAIKK +N+ + REL +++ + Sbjct: 9 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 68 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLC 175 +NI+ L F + L YLV E ++ N+ ++++ + E++ +YQ++ Sbjct: 69 KQENIVELKEAFRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIK 122 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTRYYRAPE 233 I H I+HRD+KP N+++ + LK+ DFG AR G + V TR+YR+PE Sbjct: 123 AIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPE 182 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 ++LG Y ++VD+WSVGCI+GE+ + LFPG IDQ + + LG E MK Sbjct: 183 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMK----- 237 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 + P++ GL FP + + + + + S DL+ +L +DPA R + Sbjct: 238 ---LFYSNPRFHGLRFPAV--NHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQC 292 Query: 354 LQHPYIN 360 L HP Sbjct: 293 LNHPTFQ 299 >3N9X-A nrPDB Length = 432 Score = 283 bits (725), Expect = 8e-77, Method: Composition-based stats. Identities = 118/421 (28%), Positives = 192/421 (45%), Gaps = 71/421 (16%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +N ++ G V Y IG G+ G V AYD ++NVAIKK++R F++ Sbjct: 12 ENLYFQ---GIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLID 68 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LD 162 KR RE+ ++ + II L ++ P L +F ++Y+V+E+ D++L ++ + L Sbjct: 69 CKRILREITILNRLKSDYIIRLYDLIIPDDLL-KFDELYIVLEIADSDLKKLFKTPIFLT 127 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----- 217 E + +LY +L G +H +GIIHRDLKP+N ++ DC++K+ DFGLART + Sbjct: 128 EEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNI 187 Query: 218 ------------------FMMTPYVVTRYYRAPE-VILGMGYKENVDIWSVGCIMGEMV- 257 +T +VVTR+YRAPE ++L Y +++DIWS GCI E++ Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 Query: 258 ----------RHKILFPG-----------------RDYIDQWNKVIEQLGTPCPEFMKKL 290 LFPG + DQ N + +GTP + +K + Sbjct: 248 MLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNI 307 Query: 291 -QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 +P V Y++ P + + +P + +LL ML +P KRI+ Sbjct: 308 NKPEVIKYIKLFPHRKPINLKQKYPS------------ISDDGINLLESMLKFNPNKRIT 355 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGV 409 +D AL HPY+ +I D + + + + KEV + + Sbjct: 356 IDQALDHPYLKDVRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFHPELVIPS 415 Query: 410 V 410 V Sbjct: 416 V 416 >3PG1-A nrPDB Length = 362 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 113/352 (32%), Positives = 172/352 (48%), Gaps = 29/352 (8%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP---------FQNQTHAKRAYRELVL 114 Y + I SG+ G VCA D+ VAIK++ + KR RE+ L Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLY 171 + +H NI+ L ++F +YLV ELM +L QVI + + + + Y +Y Sbjct: 83 LNHFHHPNILGLRDIFV-HFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMY 141 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 +L G+ LH AG++HRDL P NI++ + + I DF LAR T YV R+YRA Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 232 PE-VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PE V+ G+ + VD+WS GC+M EM K LF G + +Q NK++E +GTP E + Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 291 -QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 P+ R+Y+ N P ++ P A DL++KML +P +RIS Sbjct: 262 SSPSARDYLRNSLS----NVPARAWTAVVPT-------ADPVALDLIAKMLEFNPQRRIS 310 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNS 401 + AL+HPY +DP ++ + + DE + + ++ EV Sbjct: 311 TEQALRHPYFESLFDPLDLTEGLSERF--HFDESVTDVYDMHKIFTAEVERF 360 >1UA2-A nrPDB Length = 346 Score = 281 bits (720), Expect = 3e-76, Method: Composition-based stats. Identities = 95/312 (30%), Positives = 155/312 (49%), Gaps = 28/312 (8%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS---RPFQNQTHAKRAYRELVLMKCV 118 KRY+ L +G G V A D ++ VAIKK+ R + A RE+ L++ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQMLC 175 +H NII LL+ F ++ LV + M+ +L +I+ L + + L Sbjct: 70 SHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEV 234 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G + T VVTR+YRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 235 ILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 + G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + + Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-S 242 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 + +YV + + G+ +F DL+ + + +P RI+ A Sbjct: 243 LPDYVTFK-SFPGIPLHHIF------------SAAGDDLLDLIQGLFLFNPCARITATQA 289 Query: 354 LQHPYINVWYDP 365 L+ Y + P Sbjct: 290 LKMKYFSNRPGP 301 >4AGU-A nrPDB Length = 311 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 86/305 (28%), Positives = 148/305 (48%), Gaps = 22/305 (7%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +++Y+ + IG G+ G+V + + VAIKK + K A RE+ ++K + H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCGI 177 N+++LL VF ++ L LV E D + + Q + + + +Q L + Sbjct: 62 PNLVNLLEVFRRKRRLH------LVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAV 115 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPEVIL 236 H IHRD+KP NI++ +K+ DFG AR G S V TR+YR+PE+++ Sbjct: 116 NFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLV 175 Query: 237 G-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VD+W++GC+ E++ L+PG+ +DQ + + LG L P + Sbjct: 176 GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG--------DLIPRHQ 227 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 ++G+ P P+ + P + + + + A LL L +DP +R++ + L Sbjct: 228 QVFSTNQYFSGVKIPD--PEDMEPLELKFPNI-SYPALGLLKGCLHMDPTERLTCEQLLH 284 Query: 356 HPYIN 360 HPY Sbjct: 285 HPYFE 289 >3MIA-A nrPDB Length = 351 Score = 280 bits (717), Expect = 7e-76, Method: Composition-based stats. Identities = 90/321 (28%), Positives = 151/321 (47%), Gaps = 23/321 (7%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Query: 121 KNIISLLNVFTPQKTLEEFQD--VYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLC 175 +N+++L+ + + + +YLV + + +L ++ + + ++ +L Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-----GTSFMMTPYVVTRYYR 230 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR T VVT +YR Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Query: 231 APEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE---- 251 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 V V+N Y L K + D ++ A DL+ K+LV+DPA+RI Sbjct: 252 ----VWPNVDNYELYEKLELVKGQKRKVK--DRLKAYVRDPYALDLIDKLLVLDPAQRID 305 Query: 350 VDDALQHPYINVWYDPAEVEA 370 DDAL H + W DP + Sbjct: 306 SDDALNHDFF--WSDPMPSDL 324 >4RGJ-A nrPDB Length = 520 Score = 280 bits (716), Expect = 9e-76, Method: Composition-based stats. Identities = 96/365 (26%), Positives = 156/365 (42%), Gaps = 53/365 (14%) Query: 31 SYIAKHYNMSKSKVDNQFYSVE------VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA 84 +SK V+N F + + + +S ++Y+ +K +G G+ G V + D Sbjct: 23 EMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDK 82 Query: 85 VLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY 143 AIK +S+ + +T + RE+ L+K ++H NI+ L F DVY Sbjct: 83 HTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVY 142 Query: 144 LVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV----KS 199 EL D + + + ++ Q+L GI ++H ++HRDLKP NI++ K Sbjct: 143 TGGELFDEIIS---RKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKE 199 Query: 200 DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRH 259 D +KI+DFGL+ S M + T YY AP+V+ G Y E DIWS G I+ ++ Sbjct: 200 DMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSG 258 Query: 260 KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFP 319 F G + D KV Y + P++ Sbjct: 259 CPPFNGSNEYDILKKV-----------------EAGKYTFDLPQF--------------- 286 Query: 320 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQ 379 K + +A+DL+ KML+ A RIS DAL+H +I + + P + Sbjct: 287 ------KKISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSI 340 Query: 380 LDERE 384 + R+ Sbjct: 341 ANIRQ 345 >3HZT-A nrPDB Length = 467 Score = 280 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 82/304 (26%), Positives = 133/304 (43%), Gaps = 46/304 (15%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCV 118 + RYQ +K +GSGA G V D + AIK + + T E+ ++K + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI+ L F ++ +VY EL D +++ + + ++ Q+L G Sbjct: 62 DHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI---ILRQKFSEVDAAVIMKQVLSGTT 118 Query: 179 HLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +LH I+HRDLKP N++++S D +KI+DFGL+ M + T YY APEV+ Sbjct: 119 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 178 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y E D+WS G I+ ++ F G+ + +V + Sbjct: 179 R-KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK------------------ 219 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 F D + +A+ L+ ML +P+KRIS ++AL Sbjct: 220 --------------------GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALN 259 Query: 356 HPYI 359 HP+I Sbjct: 260 HPWI 263 >4E7W-A nrPDB Length = 394 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 102/329 (31%), Positives = 163/329 (49%), Gaps = 33/329 (10%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y N K IG+G+ G+V A D VAIKK+ + + + REL +M+ V H N+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ------VIQMELDHERMSYLLYQMLCGI 177 + L F ++ + LV+E + + + ++ + + +YQ+L + Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 178 KHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 ++HS GI HRD+KP N+++ LK++DFG A+ Y+ +RYYRAPE+I Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIF 214 Query: 237 G-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y N+DIWS GC+M E+++ + LFPG IDQ ++I+ LGTP E +K + Sbjct: 215 GATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTM----- 269 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 P Y FP++ P P A DL+S++L P+ R++ +AL Sbjct: 270 -----NPNYMEHKFPQIRP---HPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALC 321 Query: 356 HPYINVWYD-----PAEVEAPPPQIYDKQ 379 HP+ + P E PP + K+ Sbjct: 322 HPFFDELRTGEARMPNGRELPPLFNWTKE 350 >3NIE-A nrPDB Length = 429 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 117/419 (27%), Positives = 191/419 (45%), Gaps = 72/419 (17%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +N ++ + V Y+ IG G+ G V AYD ++NVAIKK++R F++ Sbjct: 12 ENLYFQGAI-IKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLID 70 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LD 162 KR RE+ ++ + II L ++ P+ L +F ++Y+V+E+ D++L ++ + L Sbjct: 71 CKRILREITILNRLKSDYIIRLHDLIIPEDLL-KFDELYIVLEIADSDLKKLFKTPIFLT 129 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----- 217 + + +LY +L G K +H +GIIHRDLKP+N ++ DC++KI DFGLART + Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHI 189 Query: 218 ---------------------FMMTPYVVTRYYRAPE-VILGMGYKENVDIWSVGCIMGE 255 +T +VVTR+YRAPE ++L Y ++DIWS GCI E Sbjct: 190 VNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAE 249 Query: 256 MV-----------RHKILFPG-----------------RDYIDQWNKVIEQLGTPCPEFM 287 ++ LFPG + DQ N + +GTP E + Sbjct: 250 LLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDL 309 Query: 288 KKL-QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 K + + V Y++ P G+ K + + + DLL ML + K Sbjct: 310 KCITKQEVIKYIKLFPTRDGIDLSKKY------------SSISKEGIDLLESMLRFNAQK 357 Query: 347 RISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKT 405 RI++D AL HPY+ +I D + + + + KE+ + Sbjct: 358 RITIDKALSHPYLKDVRKENLENFSTEKIILPFDDWMVLSETQLRYIFLKEIQSFHADL 416 >3DXN-A nrPDB Length = 287 Score = 278 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 82/304 (26%), Positives = 133/304 (43%), Gaps = 46/304 (15%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCV 118 + RYQ +K +GSGA G V D + AIK + + T E+ ++K + Sbjct: 19 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 +H NI+ L F ++ +VY EL D +++ + + ++ Q+L G Sbjct: 79 DHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI---ILRQKFSEVDAAVIMKQVLSGTT 135 Query: 179 HLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +LH I+HRDLKP N++++S D +KI+DFGL+ M + T YY APEV+ Sbjct: 136 YLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 195 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y E D+WS G I+ ++ F G+ + +V + Sbjct: 196 R-KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK------------------ 236 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 F D + +A+ L+ ML +P+KRIS ++AL Sbjct: 237 --------------------GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALN 276 Query: 356 HPYI 359 HP+I Sbjct: 277 HPWI 280 >3UTO-A nrPDB Length = 573 Score = 277 bits (709), Expect = 6e-75, Method: Composition-based stats. Identities = 75/368 (20%), Positives = 139/368 (37%), Gaps = 52/368 (14%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 ++ +Y+ + Q+Y V VL Y + +G+GA G+V + N Sbjct: 126 GTVSSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNF 185 Query: 91 AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD 150 A K + P ++ + +E+ M + H +++L + F E+ ++ ++ E M Sbjct: 186 AAKFVMTPH--ESDKETVRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMS 237 Query: 151 AN-LCQVI---QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSDCTLK 204 L + + ++ + + Q+ G+ H+H +H DLKP NI+ K LK Sbjct: 238 GGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELK 297 Query: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 ++DFGL + T + APEV G D+WSVG + ++ F Sbjct: 298 LIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFG 357 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 G + + + ++ N D Sbjct: 358 GENDDETL---------------RNVKSCDWN-----------------------MDDSA 379 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 + +D + K+L+ DP R+++ AL+HP++ P P Y K D + Sbjct: 380 FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIK 439 Query: 385 HTIEEWKE 392 + W E Sbjct: 440 TKYDAWPE 447 >4MVF-A nrPDB Length = 506 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 130/306 (42%), Gaps = 53/306 (17%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 +Y + +G G G V D V ++ AIK+ + + R ++E+ +MK ++H Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLK--NINRFFQEIEIMKKLDHP 114 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVI--QMELDHERMSYLLYQMLCGIK 178 NI+ L + E +YL+MEL L I + + ++ Q+ I Sbjct: 115 NIVKLYETY------ENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIF 168 Query: 179 HLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +LHS I+HRDLKP N + D LKI+DFGL++ GT T T YY AP+V+ Sbjct: 169 YLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVL 228 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y + DIWS G IM ++ F G + KV Sbjct: 229 DG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKV-------------------- 267 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 F +S A++L++K+L +P +R ++++AL Sbjct: 268 ------------------KKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALN 309 Query: 356 HPYINV 361 HP+I Sbjct: 310 HPWITQ 315 >1KOA-A nrPDB Length = 491 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 75/368 (20%), Positives = 139/368 (37%), Gaps = 52/368 (14%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 ++ +Y+ + Q+Y V VL Y + +G+GA G+V + N Sbjct: 20 GTVSSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNF 79 Query: 91 AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD 150 A K + P ++ + +E+ M + H +++L + F E+ ++ ++ E M Sbjct: 80 AAKFVMTPH--ESDKETVRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMS 131 Query: 151 AN-LCQVI---QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSDCTLK 204 L + + ++ + + Q+ G+ H+H +H DLKP NI+ K LK Sbjct: 132 GGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELK 191 Query: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 ++DFGL + T + APEV G D+WSVG + ++ F Sbjct: 192 LIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFG 251 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 G + + + ++ N D Sbjct: 252 GENDDETL---------------RNVKSCDWN-----------------------MDDSA 273 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 + +D + K+L+ DP R+++ AL+HP++ P P Y K D + Sbjct: 274 FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIK 333 Query: 385 HTIEEWKE 392 + W E Sbjct: 334 TKYDAWPE 341 >5ES1-A nrPDB Length = 328 Score = 273 bits (699), Expect = 9e-74, Method: Composition-based stats. Identities = 83/351 (23%), Positives = 144/351 (41%), Gaps = 59/351 (16%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + Y+ L+ IG G V A + R VAIK + + N + ++ +RE+ +MK +NH Sbjct: 14 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 73 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQMELDHERMSYLLYQMLCGI 177 NI+ L V +KTL YLVME A V + + Q++ + Sbjct: 74 PNIVKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAV 127 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 + H I+HRDLK N+++ ++ +KI DFG + + + + Y APE+ G Sbjct: 128 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQG 187 Query: 238 MGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y VDIWS+G I+ +V + F G + + +V+ Sbjct: 188 KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLR------------------- 228 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 ++ +L + LV++PAKR +++ ++ Sbjct: 229 -----------------------GKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKD 265 Query: 357 PYINVWYDPAEVEAPPPQIYDKQLDER-------EHTIEEWKELIYKEVMN 400 +IN+ Y+ E++ D +R +T EE KE + + N Sbjct: 266 KWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYN 316 >5AIR-A nrPDB Length = 430 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 87/310 (28%), Positives = 152/310 (49%), Gaps = 27/310 (8%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y + K IG+G+ G+V A VAIKK+ + + + REL +M+ ++H NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 119 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ------MELDHERMSYLLYQMLCGI 177 + L F ++ + LV++ + + +V + L + +YQ+ + Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTL-KILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 ++HS GI HRD+KP N+++ D + K+ DFG A+ Y+ +RYYRAPE+I Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 239 Query: 237 G-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y ++D+WS GC++ E++ + +FPG +DQ ++I+ LGTP E ++++ Sbjct: 240 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM----- 294 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 P Y FP++ P +A L S++L P R++ +A Sbjct: 295 -----NPNYTEFKFPQI---KAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACA 346 Query: 356 HPYINVWYDP 365 H + + DP Sbjct: 347 HSFFDELRDP 356 >5U6Y-A nrPDB Length = 461 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 89/394 (22%), Positives = 160/394 (40%), Gaps = 65/394 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 YQ + +G GA +V + + A K ++ + ++ RE + + + H NI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 + L + + + D+ EL + V + S+ + Q+L + H H Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDI---VAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 184 GIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMG 239 G++HRDLKP N+++ S +K+ DFGLA G + T Y +PEV+ Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y + VD+W+ G I+ ++ F D + ++ Sbjct: 179 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------------ 214 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K FP D++ P +A+DL++KML I+P+KRI+ +AL+HP+I Sbjct: 215 ---KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPSKRITAAEALKHPWI 260 Query: 360 NVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGA 419 + A R+ T++ K+ N+ K K ++ + Sbjct: 261 SHRSTVASCM------------HRQETVDCLKKF------NARRKLKGAILTTMLATRNF 302 Query: 420 AVNSSESLPPSSSVNDISSMSTDQTLASDTDSSL 453 + S S V + SS ST+ T+ + D+ + Sbjct: 303 SGGKSGGNKKSDGVKE-SSESTNTTIEDE-DTKV 334 >2VN9-A nrPDB Length = 301 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 84/358 (23%), Positives = 145/358 (40%), Gaps = 69/358 (19%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 YQ + +G GA +V + A K ++ + ++ RE + + + H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIK 178 NI+ L + + + YLV +L+ L + I + S+ + Q+L + Sbjct: 64 NIVRLHDSISEEGFH------YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 117 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCT---LKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEV 234 H H GI+HRDLKP N+++ S +K+ DFGLA G + T Y +PEV Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + Y + VD+W+ G I+ ++ F D + ++ Sbjct: 178 LRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI------------------- 218 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 K FP D++ P +A+DL++KML I+PAKRI+ +AL Sbjct: 219 --------KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPAKRITASEAL 259 Query: 355 QHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKG 412 +HP+I A + R+ T++ K+ N+ K K ++ Sbjct: 260 KHPWICQRSTVASMM------------HRQETVDCLKKF------NARRKLKGAILTT 299 >2I6L-A nrPDB Length = 320 Score = 273 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 101/328 (30%), Positives = 170/328 (51%), Gaps = 29/328 (8%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 F + RY +LKP+G G G+V +A D D+ VAIKK+ + K A RE+ +++ Sbjct: 7 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI--VLTDPQSVKHALREIKIIRR 64 Query: 118 VNHKNIISLLNVFTPQKT--------LEEFQDVYLVMELMDANLCQVI-QMELDHERMSY 168 ++H NI+ + + P + L E VY+V E M+ +L V+ Q L E Sbjct: 65 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 124 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSF----MMTPY 223 +YQ+L G+K++HSA ++HRDLKP+N+ + D LKI DFGLAR + ++ Sbjct: 125 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 +VT++YR+P ++L Y + +D+W+ GCI EM+ K LF G ++Q ++E + Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 244 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 E ++L + Y+ N +L P + +A D L ++L Sbjct: 245 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPG------------ISREAVDFLEQILTF 292 Query: 343 DPAKRISVDDALQHPYINVWYDPAEVEA 370 P R++ ++AL HPY++++ P + Sbjct: 293 SPMDRLTAEEALSHPYMSIYSFPMDEPI 320 >2VZ6-A nrPDB Length = 313 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 82/362 (22%), Positives = 145/362 (40%), Gaps = 63/362 (17%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 V++G YQ + +G GA +V + + A K ++ + ++ Sbjct: 10 GVDLGTENLYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE 69 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 RE + + + H NI+ L + + + D+ EL + V + S+ Sbjct: 70 REARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDI---VAREYYSEADASHC 126 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVV 225 + Q+L + H H G++HRDLKP N+++ S +K+ DFGLA G + Sbjct: 127 IQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAG 186 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y +PEV+ Y + VD+W+ G I+ ++ F D + ++ Sbjct: 187 TPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI---------- 236 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 K FP D++ P +A+DL++KML I+P+ Sbjct: 237 -----------------KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPS 268 Query: 346 KRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKT 405 KRI+ +AL+HP+I+ A R+ T++ K+ N+ K Sbjct: 269 KRITAAEALKHPWISHRSTVASCM------------HRQETVDCLKKF------NARRKL 310 Query: 406 KN 407 K Sbjct: 311 KG 312 >5IG1-A nrPDB Length = 344 Score = 272 bits (695), Expect = 3e-73, Method: Composition-based stats. Identities = 90/378 (23%), Positives = 146/378 (38%), Gaps = 79/378 (20%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 +M Y V++ D IG GA V + A+K ++ Sbjct: 3 HMETETSFFDLYDVDLKDKR----------SVIGKGAFSTVHRCVNKRTGEVCAVKVIAL 52 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQV 156 + + RE+ + + H++I+S+ F + YLV E + L Sbjct: 53 KSLRSSEINKIKREIGICSSLQHEHIVSMRRAFRDESHF------YLVFEYVSGGELFDE 106 Query: 157 I--QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLA 211 I + + + S ++Q+L ++H HS IIHRDLKP N+++ S + +KI DFGLA Sbjct: 107 IVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLA 166 Query: 212 RTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 + T Y +PEVI + Y VD+W+ G I+ ++ F D+ Sbjct: 167 VIMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKL 226 Query: 272 WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQ 331 + ++ K FP DS+ A Sbjct: 227 YAQI---------------------------KNCQYDFPSPEWDSVTTA----------- 248 Query: 332 ARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWK 391 A++L+ ML +P +R +V + LQHP+I P V R+ T+EE K Sbjct: 249 AKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSV-------------HRQATLEELK 295 Query: 392 ELIYKEVMNSEEKTKNGV 409 + N+ K K GV Sbjct: 296 KF------NARRKLKGGV 307 >3GC0-A nrPDB Length = 329 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 102/320 (31%), Positives = 156/320 (48%), Gaps = 28/320 (8%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 + T + RY+ + +G G G V A D V + VAIK++ + + A RE+ L+ Sbjct: 28 PSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLL 87 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMSYLLYQM 173 K + H+NII L +V L L+ E + +L + + ++ + LYQ+ Sbjct: 88 KELQHRNIIELKSVIHHNHRLH------LIFEYAENDLKKYMDKNPDVSMRVIKSFLYQL 141 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLARTAG-TSFMMTPYVVTR 227 + G+ HS +HRDLKP N+++ LKI DFGLAR G T ++T Sbjct: 142 INGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITL 201 Query: 228 YYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 +YR PE++LG Y +VDIWS+ CI EM+ LFPG IDQ K+ E LG P Sbjct: 202 WYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTT 261 Query: 287 MKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 + + ++ ++ PK+ G T ++ L + ML +DP K Sbjct: 262 WPGVT-ALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTA-----------MLEMDPVK 309 Query: 347 RISVDDALQHPYINV-WYDP 365 RIS +AL+HPY + +DP Sbjct: 310 RISAKNALEHPYFSHNDFDP 329 >4YZB-A nrPDB Length = 491 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 91/336 (27%), Positives = 145/336 (43%), Gaps = 47/336 (13%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ-THAKRAYRE 111 V ST RY+ + +G G+ G V D V + A+K +S+ Q T + +E Sbjct: 21 VQHSTAAFSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKE 80 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLY 171 + L+K ++H NI+ L F + +VY EL D + + + ++ Sbjct: 81 VELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIIS---RKRFSEVDAARIIR 137 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRY 228 Q+L GI ++H I+HRDLKP N+++++ D ++I+DFGL+ ++ M + T Y Sbjct: 138 QVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAY 197 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y APEV+ G Y E D+WS G I+ ++ F G + D KV + Sbjct: 198 YIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEK----------- 245 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 F D K + A+DL+ KML P RI Sbjct: 246 ---------------------------GKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRI 278 Query: 349 SVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDERE 384 S DAL+H ++ D A P + L+ R+ Sbjct: 279 SARDALEHEWLKT-TDAATDSIDVPSLESTILNIRQ 313 >5G6V-A nrPDB Length = 324 Score = 270 bits (691), Expect = 7e-73, Method: Composition-based stats. Identities = 91/304 (29%), Positives = 144/304 (47%), Gaps = 24/304 (7%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ Y L +G G V + D VA+K++ + + A RE+ L+K + H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 59 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQMLCGI 177 NI++L ++ +K+L LV E +D +L Q + ++ + L+Q+L G+ Sbjct: 60 ANIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGL 113 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVIL 236 + H ++HRDLKP N+++ LK+ DFGLAR + VVT +YR P+++L Sbjct: 114 AYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILL 173 Query: 237 G-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y +D+W VGCI EM + LFPG +Q + + LGTP E + Sbjct: 174 GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEE 233 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 N PKY H S DLL+K+L + RIS +DA++ Sbjct: 234 FKTYNYPKYRAEALLS------------HAPRLDSDGADLLTKLLQFEGRNRISAEDAMK 281 Query: 356 HPYI 359 HP+ Sbjct: 282 HPFF 285 >4D28-A nrPDB Length = 446 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 89/419 (21%), Positives = 157/419 (37%), Gaps = 82/419 (19%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVN 119 + +Y+ + IG G V A + NVAIK +++ + RE+ +MK V Sbjct: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H NI+ L V L +Y+V+E + L I + L + Q++ Sbjct: 68 HPNIVRLYEV------LASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDA 121 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-FMMTPYVVTRYYRAPEVI 235 + H HS G+ HRDLKP N+++ ++ LK+ DFGL+ ++ T Y APEV+ Sbjct: 122 VAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL 181 Query: 236 LGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 G GY DIWS G I+ ++ + F D + K+ Sbjct: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI------------------- 222 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 A P F +++ + L+ ++L +P RI + Sbjct: 223 --------NAAEFDCPPWF---------------SAEVKFLIHRILDPNPKTRIQIQGIK 259 Query: 355 QHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQP 414 + P+ Y P + LD+ + + E N E + ++ Sbjct: 260 KDPWFRKNYVPIRAREEE----EVNLDDIRAVFDGIEGSYVAE--NVERNDEGPLM---- 309 Query: 415 SPSGAAVNSSESLPPSSSVNDIS------------SMSTDQTLASDTDSSLEASAGPLG 461 +N+ E + S +N + + + S+ +++EA A +G Sbjct: 310 ------MNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMG 362 >3E3P-A nrPDB Length = 360 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 104/351 (29%), Positives = 166/351 (47%), Gaps = 26/351 (7%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 + + + R+Q + G G G V + +VAIKK+ Q+ R + + Sbjct: 16 ERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQD 72 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYL--VMELMDANLCQVIQMELDHER------M 166 + ++H NI+ L + F + +D+YL VME + L + + + + Sbjct: 73 LAVLHHPNIVQLQSYFYTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILI 131 Query: 167 SYLLYQMLCGIKHLH--SAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPY 223 L+Q++ I LH S + HRD+KP N++V D TLK+ DFG A+ S Y Sbjct: 132 KVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAY 191 Query: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 + +RYYRAPE+I G Y VDIWSVGCI EM+ + +F G + Q ++++ LG P Sbjct: 192 ICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCP 251 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 E ++KL P+ + K G+ + +F D H+ A +A DLLS +L Sbjct: 252 SREVLRKLNPSHTDVDLYNSK--GIPWSNVFSD--------HSLKDAKEAYDLLSALLQY 301 Query: 343 DPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKEL 393 P +R+ +AL HPY + +DPA + + + IE E Sbjct: 302 LPEERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEA 352 >5KZ7-A nrPDB Length = 346 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 74/324 (22%), Positives = 137/324 (42%), Gaps = 52/324 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ LK IG G V A + + VA+K + + N + ++ +RE+ +MK +NH NI Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQMELDHERMSYLLYQMLCGIKHL 180 + L V +KTL YLVME V + + Q++ +++ Sbjct: 95 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H I+HRDLK N+++ +D +KI DFG + + + + Y APE+ G Y Sbjct: 149 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKY 208 Query: 241 K-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 VD+WS+G I+ +V + F G++ + +V+ Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR---------------------- 246 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 ++ +LL K L+++P+KR +++ ++ ++ Sbjct: 247 --------------------GKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 286 Query: 360 NVWYDPAEVEAPPPQIYDKQLDER 383 NV ++ E++ + D + R Sbjct: 287 NVGHEDDELKPYVEPLPDYKDPRR 310 >2QNJ-A nrPDB Length = 328 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 81/361 (22%), Positives = 144/361 (39%), Gaps = 63/361 (17%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 +G + Y+ LK IG G V A + R VAIK + + N T ++ +RE+ Sbjct: 3 MGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREV 62 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQMELDHERMSYL 169 +MK +NH NI+ L V +KTL YL+ME V + + Sbjct: 63 RIMKILNHPNIVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSK 116 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 Q++ +++ H I+HRDLK N+++ +D +KI DFG + + + + Y Sbjct: 117 FRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPY 176 Query: 230 RAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 APE+ G Y VD+WS+G I+ +V + F G++ + +V+ Sbjct: 177 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR----------- 225 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 ++ +LL + LV++P KR Sbjct: 226 -------------------------------GKYRIPFYMSTDCENLLKRFLVLNPIKRG 254 Query: 349 SVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDER-----------EHTIEEWKELIYKE 397 +++ ++ +IN ++ E++ D +R E E ++ Y E Sbjct: 255 TLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDE 314 Query: 398 V 398 + Sbjct: 315 I 315 >5Y86-A nrPDB Length = 588 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 92/355 (25%), Positives = 159/355 (44%), Gaps = 34/355 (9%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 I N D + V + RY+ LK IG G+ G V YD L + V Sbjct: 180 GVIGGPNNGGYDDADGAYIHV----PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYV 235 Query: 91 AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD 150 A+K + + ++A E+ +++ + ++ +NV ++ V + EL+ Sbjct: 236 ALKMVR---NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS 292 Query: 151 ANLCQVIQM----ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT--LK 204 +L ++I+ + + +L + LH IIH DLKP NI++K K Sbjct: 293 IDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTK 352 Query: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 ++DFG + + Y+ +R+YRAPE+ILG Y +DIWS GCI+ E++ + LFP Sbjct: 353 VIDFGSSCF--EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFP 410 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR--PKYAGLTFPKLFPDSLFPADS 322 G D DQ ++E LG P P+ +++ + ++ ++ P+Y +T L S Sbjct: 411 GEDEGDQLACMMELLGMPPPKLLEQ-SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRS 469 Query: 323 EHNKLKASQ----------------ARDLLSKMLVIDPAKRISVDDALQHPYINV 361 K + + L + L DP+ R++ AL+HP+I+ Sbjct: 470 RRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISK 524 >3ZDU-A nrPDB Length = 325 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 99/305 (32%), Positives = 153/305 (50%), Gaps = 23/305 (7%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ Y+ L +G G+ G V + VAIK Q+ K A RE+ +K +H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQFHH 60 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGI 177 +N+++L+ VF +K ++LV E +D + +Q L+ +R+ L+Q+L I Sbjct: 61 ENLVNLIEVFRQKK------KIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAI 114 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE-VI 235 +LHS IIHRD+KP NI+V K+ DFG ART + V TR+YRAPE V+ Sbjct: 115 DYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVL 174 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y + VDIW++GC++ EM P +D +K++ ++G L P ++ Sbjct: 175 KDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVG--------NLSPHLQ 226 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 N P +AG+ P++ A ++ KL A D++ L IDPA RIS D L Sbjct: 227 NIFSKSPIFAGVVLPQV--QHPKNARKKYPKLNGLLA-DIVHACLQIDPADRISSSDLLH 283 Query: 356 HPYIN 360 H Y Sbjct: 284 HEYFT 288 >2V7O-A nrPDB Length = 336 Score = 267 bits (683), Expect = 7e-72, Method: Composition-based stats. Identities = 86/376 (22%), Positives = 154/376 (40%), Gaps = 71/376 (18%) Query: 44 VDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103 +N ++ + FT YQ + +G GA +V + A K ++ + Sbjct: 15 TENLYFQSMATCTRFT--DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSAR 72 Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QME 160 ++ RE + + + H NI+ L + + + YLV +L+ L + I + Sbjct: 73 DHQKLEREARICRLLKHPNIVRLHDSISEEGFH------YLVFDLVTGGELFEDIVAREY 126 Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT---LKILDFGLA-RTAGT 216 S+ ++Q+L + H+H I+HRDLKP N+++ S C +K+ DFGLA G Sbjct: 127 YSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGE 186 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 + T Y +PEV+ Y + VDIW+ G I+ ++ F D + ++ Sbjct: 187 QQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI- 245 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 336 K FP D++ P +A++L+ Sbjct: 246 --------------------------KAGAYDFPSPEWDTVTP-----------EAKNLI 268 Query: 337 SKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 ++ML I+PAKRI+ D AL+HP++ A + R+ T+E ++ Sbjct: 269 NQMLTINPAKRITADQALKHPWVCQRSTVASMM------------HRQETVECLRKF--- 313 Query: 397 EVMNSEEKTKNGVVKG 412 N+ K K ++ Sbjct: 314 ---NARRKLKGAILTT 326 >2BDW-A nrPDB Length = 362 Score = 267 bits (682), Expect = 8e-72, Method: Composition-based stats. Identities = 83/384 (21%), Positives = 146/384 (38%), Gaps = 74/384 (19%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 Y + +G GA +V A K ++ + ++ RE + + + Sbjct: 27 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 86 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLLYQMLCG 176 H NI+ L + + YLV +L+ ++ E S+ + Q+L Sbjct: 87 HPNIVRLHDSIQEESFH------YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 140 Query: 177 IKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 I + HS GI+HR+LKP N+++ S +K+ DFGLA S + T Y +PE Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 200 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y + VDIW+ G I+ ++ F D + ++ Sbjct: 201 VLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------ 242 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 K +P D++ P +A+ L+ ML ++P KRI+ D A Sbjct: 243 ---------KAGAYDYPSPEWDTVTP-----------EAKSLIDSMLTVNPKKRITADQA 282 Query: 354 LQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGV---- 409 L+ P+I + V + R+ T++ K+ N+ K K + Sbjct: 283 LKVPWI---CNRERVASAI---------HRQDTVDCLKKF------NARRKLKGAILTTM 324 Query: 410 --VKGQPSPSGAAVNSSESLPPSS 431 + + +N E PPS+ Sbjct: 325 IATRNLSNLGRNLLNKKEQGPPST 348 >3MN3-A nrPDB Length = 271 Score = 267 bits (682), Expect = 8e-72, Method: Composition-based stats. Identities = 76/313 (24%), Positives = 133/313 (42%), Gaps = 54/313 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCVNHKN 122 YQ +K +G G+ G V AY + VA+K +++ ++ + R RE+ ++ + H + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHL 180 II L +V + ++ +V+E L I + ++ + Q++ +++ Sbjct: 66 IIKLYDVI------KSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYC 119 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H I+HRDLKP N+++ +KI DFGL+ + + Y APEVI G Y Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 241 -KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 VD+WS G I+ M+ ++ F E + L + N V Sbjct: 180 AGPEVDVWSCGVILYVMLCRRLPFD-------------------DESIPVLFKNISNGVY 220 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 PK+ + A L+ +ML+++P RIS+ + +Q + Sbjct: 221 TLPKF-----------------------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWF 257 Query: 360 NVWYDPAEVEAPP 372 V D E PP Sbjct: 258 KV--DLPEYLLPP 268 >5ZTN-A nrPDB Length = 429 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 95/362 (26%), Positives = 160/362 (44%), Gaps = 34/362 (9%) Query: 23 GFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAY 82 G + + N + V V RY+ LK IG G+ G V AY Sbjct: 62 GLNAKKRQGMTGGPNNGGYDDDQGSYVQV----PHDHVAYRYEVLKVIGKGSFGQVVKAY 117 Query: 83 DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDV 142 D + ++VA+K + + ++A E+ +++ + ++ + +NV + + Sbjct: 118 DHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHI 174 Query: 143 YLVMELMDANLCQVIQM----ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 198 + EL+ NL ++I+ + + +L + LH IIH DLKP NI++K Sbjct: 175 CMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK 234 Query: 199 SDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM 256 +K++DFG + + Y+ +R+YRAPEVILG Y +D+WS+GCI+ E+ Sbjct: 235 QQGRSGIKVIDFGSSCY--EHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAEL 292 Query: 257 VRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR--PKYAGLTFPKLFP 314 + L PG D DQ +IE LG P + + +N+V ++ P+Y +T Sbjct: 293 LTGYPLLPGEDEGDQLACMIELLGMPSQKLLDA-SKRAKNFVSSKGYPRYCTVTTLSDGS 351 Query: 315 DSLFPADSEHNKLK----------------ASQARDLLSKMLVIDPAKRISVDDALQHPY 358 L S KL+ D L + L DPA R++ AL+HP+ Sbjct: 352 VVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 411 Query: 359 IN 360 + Sbjct: 412 LR 413 >4CFF-A nrPDB Length = 571 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 92/393 (23%), Positives = 143/393 (36%), Gaps = 62/393 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 32 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 91 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H +II L V + D ++VME + L I ++ L Q+L Sbjct: 92 HPHIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 145 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 146 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VDIWS G I+ ++ + F E + L +R Sbjct: 206 GRLYAGPEVDIWSCGVILYALLCGTLPFD-------------------DEHVPTLFKKIR 246 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 V P+Y + LL ML +DP KR ++ D + Sbjct: 247 GGVFYIPEYLNRSVAT-----------------------LLMHMLQVDPLKRATIKDIRE 283 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNS----EEKTKNGVVK 411 H + P + DE + E E EVMNS + + + V Sbjct: 284 HEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAY 343 Query: 412 GQPSPSGAAVNSSESL-----PPSSSVNDISSM 439 + +N + PPS S D S+M Sbjct: 344 HLIIDNRRIMNQASEFYLASSPPSGSFMDDSAM 376 >5FG8-A nrPDB Length = 285 Score = 265 bits (677), Expect = 4e-71, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 130/307 (42%), Gaps = 51/307 (16%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 Y + +G GA IV A K ++ ++ RE + + ++ Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH 71 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLLYQMLCG 176 H NI+ L + +++E YLV +L+ ++ E S+ + Q+L Sbjct: 72 HPNIVRLHD------SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 125 Query: 177 IKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAP 232 + H H G++HRDLKP N+++ S +K+ DFGLA G + T Y +P Sbjct: 126 VNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSP 185 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 EV+ Y ++VDIW+ G I+ ++ F D ++++ Sbjct: 186 EVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI----------------- 228 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 K +P D++ P +A++L+++ML ++P KRI+ + Sbjct: 229 ----------KAGAYDYPSPEWDTVTP-----------EAKNLINQMLTVNPNKRITAAE 267 Query: 353 ALQHPYI 359 AL+HP+I Sbjct: 268 ALKHPWI 274 >3SOA-A nrPDB Length = 444 Score = 264 bits (675), Expect = 5e-71, Method: Composition-based stats. Identities = 80/378 (21%), Positives = 150/378 (39%), Gaps = 63/378 (16%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 + YQ + +G GA +V + + A ++ + ++ RE + + + Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLK 68 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 179 H NI+ L + + + D+ EL + V + S+ + Q+L + H Sbjct: 69 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDI---VAREYYSEADASHCIQQILEAVLH 125 Query: 180 LHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVI 235 H G++HR+LKP N+++ S +K+ DFGLA G + T Y +PEV+ Sbjct: 126 CHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y + VD+W+ G I+ ++ F D + ++ Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI-------------------- 225 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 K FP D++ P +A+DL++KML I+P+KRI+ +AL+ Sbjct: 226 -------KAGAYDFPSPEWDTVTP-----------EAKDLINKMLTINPSKRITAAEALK 267 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPS 415 HP+I+ A R+ T++ K+ N+ K K ++ + Sbjct: 268 HPWISHRSTVASCM------------HRQETVDCLKKF------NARRKLKGAILTVMLA 309 Query: 416 PSGAAVNSSESLPPSSSV 433 +V E + + + Sbjct: 310 TRNFSVRKQEIIKVTEQL 327 >5EZV-A nrPDB Length = 560 Score = 264 bits (675), Expect = 6e-71, Method: Composition-based stats. Identities = 83/346 (23%), Positives = 127/346 (36%), Gaps = 53/346 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 27 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 86 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H +II L V + D ++VME + L I ++ L Q+L Sbjct: 87 HPHIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 140 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 141 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 200 Query: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VDIWS G I+ ++ + F E + L +R Sbjct: 201 GRLYAGPEVDIWSCGVILYALLCGTLPFD-------------------DEHVPTLFKKIR 241 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 V P+Y + LL ML +DP KR ++ D + Sbjct: 242 GGVFYIPEYLNRSVAT-----------------------LLMHMLQVDPLKRATIKDIRE 278 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNS 401 H + P + DE + E E EVMNS Sbjct: 279 HEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNS 324 >3BHH-A nrPDB Length = 295 Score = 264 bits (674), Expect = 7e-71, Method: Composition-based stats. Identities = 84/353 (23%), Positives = 143/353 (40%), Gaps = 69/353 (19%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 YQ + IG GA +V A K ++ + ++ RE + + + H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIK 178 NI+ L + + + YLV +L+ L + I + S+ + Q+L + Sbjct: 64 NIVRLHDSISEEGFH------YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 117 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCT---LKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEV 234 H H G++HRDLKP N+++ S C +K+ DFGLA G + T Y +PEV Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + Y + VDIW+ G I+ ++ F D + ++ Sbjct: 178 LRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI------------------- 218 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 K FP D++ P +A++L+++ML I+PAKRI+ +AL Sbjct: 219 --------KAGAYDFPSPEWDTVTP-----------EAKNLINQMLTINPAKRITAHEAL 259 Query: 355 QHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKN 407 +HP++ A + R+ T+E K+ N+ K K Sbjct: 260 KHPWVCQRSTVASMM------------HRQETVECLKKF------NARRKLKG 294 >3KK8-A nrPDB Length = 284 Score = 263 bits (673), Expect = 9e-71, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 122/306 (39%), Gaps = 50/306 (16%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 Y + +G GA +V A K ++ + ++ RE + + + Sbjct: 4 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ 63 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLLYQMLCG 176 H NI+ L + + YLV +L+ ++ E S+ + Q+L Sbjct: 64 HPNIVRLHDSIQEESFH------YLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 117 Query: 177 IKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 I + HS GI+HR+LKP N+++ S +K+ DFGLA S + T Y +PE Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 177 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y + VDIW+ G I+ ++ F D + ++ Sbjct: 178 VLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------ 219 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 K +P D++ P +A+ L+ ML ++P KRI+ D A Sbjct: 220 ---------KAGAYDYPSPEWDTVTP-----------EAKSLIDSMLTVNPKKRITADQA 259 Query: 354 LQHPYI 359 L+ P+I Sbjct: 260 LKVPWI 265 >3H4J-B nrPDB Length = 336 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 128/302 (42%), Gaps = 52/302 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH-AKRAYRELVLMKCVNHKN 122 Y + +G G+ G V A + VA+K +SR ++ R RE+ +K + H + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHL 180 II L +V T D+ +V+E L I + + + Q++C I++ Sbjct: 71 IIKLYDVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H I+HRDLKP N+++ + +KI DFGL+ + + Y APEVI G Y Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 241 -KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 VD+WS G ++ M+ ++ F EF+ L V + V Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFD-------------------DEFIPNLFKKVNSCVY 225 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P + + A+ L+ +M+V DP +RI++ + + P+ Sbjct: 226 VMPDF-----------------------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 Query: 360 NV 361 NV Sbjct: 263 NV 264 >4REW-A nrPDB Length = 540 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 125/345 (36%), Gaps = 53/345 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 5 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 64 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H +II L V + D+++VME + L I LD + L Q+L G Sbjct: 65 HPHIIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSG 118 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 119 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 178 Query: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VDIWS G I+ ++ + F + K+ + + Sbjct: 179 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI---------------- 222 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 + LL ML +DP KR S+ D + Sbjct: 223 --------------------------FYTPQYLNPSVISLLKHMLQVDPMKRASIKDIRE 256 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 H + P DE + E E +EV++ Sbjct: 257 HEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 301 >4RED-A nrPDB Length = 351 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 125/345 (36%), Gaps = 53/345 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 13 IGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 72 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H +II L V + D+++VME + L I LD + L Q+L G Sbjct: 73 HPHIIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSG 126 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 Query: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VDIWS G I+ ++ + F + K+ + + Sbjct: 187 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI---------------- 230 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 + LL ML +DP KR S+ D + Sbjct: 231 --------------------------FYTPQYLNPSVISLLKHMLQVDPMKRASIKDIRE 264 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 H + P DE + E E +EV++ Sbjct: 265 HEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCEKFECSEEEVLS 309 >4CFH-A nrPDB Length = 493 Score = 260 bits (665), Expect = 9e-70, Method: Composition-based stats. Identities = 78/345 (22%), Positives = 125/345 (36%), Gaps = 53/345 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 32 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR 91 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H +II L V + D+++VME + L I LD + L Q+L G Sbjct: 92 HPHIIKLYQVISTPS------DIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSG 145 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 146 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VDIWS G I+ ++ + F + K+ + + Sbjct: 206 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI---------------- 249 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 + LL ML +DP KR ++ D + Sbjct: 250 --------------------------FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIRE 283 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 H + P DE + E E +EV++ Sbjct: 284 HEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 328 >3EB0-A nrPDB Length = 383 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 104/365 (28%), Positives = 172/365 (47%), Gaps = 59/365 (16%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 T K+Y K +G+G+ GIVC +D + A+KK+ + + + REL +MK + Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN------RELDIMKVL 57 Query: 119 NHKNIISLLNVFTPQKTLE--------------------------------EFQDVYLVM 146 +H NII L++ F E + + + ++M Sbjct: 58 DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIM 117 Query: 147 ELMDANLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS- 199 E + L +V++ + +S +YQ+ + +HS GI HRD+KP N++V S Sbjct: 118 EYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK 177 Query: 200 DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVR 258 D TLK+ DFG A+ S Y+ +R+YRAPE++LG Y ++D+WS+GC+ GE++ Sbjct: 178 DNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELIL 237 Query: 259 HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLF 318 K LF G IDQ ++I+ +GTP E M ++ P Y + FP L Sbjct: 238 GKPLFSGETSIDQLVRIIQIMGTPTKEQMIRM----------NPHYTEVRFPTLKAKDWR 287 Query: 319 PADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDK 378 E S A DLL ++L +P RI+ +A+ HP+ + + E E + Sbjct: 288 KILPEGTP---SLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPH 344 Query: 379 QLDER 383 +++ Sbjct: 345 GVNQN 349 >4FG9-A nrPDB Length = 320 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 132/311 (42%), Gaps = 51/311 (16%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 + Y +G+GA V A D + VAIK +++ E+ + Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAV 69 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLLY 171 + + H NI++L +++ E +YL+M+L+ ++++ S L++ Sbjct: 70 LHKIKHPNIVALDDIY------ESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF 123 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIV---VKSDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 Q+L +K+LH GI+HRDLKP N++ + D + I DFGL++ +++ T Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y APEV+ Y + VD WS+G I ++ F + + ++++ Sbjct: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILK----------- 232 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 A F + D + + A+D + ++ DP KR Sbjct: 233 ----------------AEYEFDSPYWDDI-----------SDSAKDFIRHLMEKDPEKRF 265 Query: 349 SVDDALQHPYI 359 + + ALQHP+I Sbjct: 266 TCEQALQHPWI 276 >3Q5I-A nrPDB Length = 504 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 82/327 (25%), Positives = 138/327 (42%), Gaps = 62/327 (18%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN----------- 101 V + + Y ++ +GSGA G V + AIK + + + Sbjct: 27 VRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNI 86 Query: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--Q 158 + + Y E+ L+K ++H NII L +VF +K YLV E + L + I + Sbjct: 87 EKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYF------YLVTEFYEGGELFEQIINR 140 Query: 159 MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC---TLKILDFGLARTAG 215 + D + ++ Q+L GI +LH I+HRD+KP NI++++ +KI+DFGL+ Sbjct: 141 HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFS 200 Query: 216 TSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 + + + T YY APEV+ Y E D+WS G IM ++ F G++ D KV Sbjct: 201 KDYKLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKV 259 Query: 276 IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDL 335 + + D K + +A++L Sbjct: 260 EK--------------------------------------GKYYFDFNDWKNISDEAKEL 281 Query: 336 LSKMLVIDPAKRISVDDALQHPYINVW 362 + ML D KR + ++AL +I + Sbjct: 282 IKLMLTYDYNKRCTAEEALNSRWIKKY 308 >2JC6-A nrPDB Length = 334 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 134/312 (42%), Gaps = 51/312 (16%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV 113 + K ++ + +G+GA V A + + A+K + + + E+ Sbjct: 14 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IENEIA 72 Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLL 170 +++ + H+NI++L +++ E +YLVM+L+ ++++ + S L+ Sbjct: 73 VLRKIKHENIVALEDIY------ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 126 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 Q+L + +LH GI+HRDLKP N++ + + I DFGL++ G +M+ T Sbjct: 127 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP 186 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y APEV+ Y + VD WS+G I ++ F + + ++++ Sbjct: 187 GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILK---------- 236 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 A F + D + + A+D + ++ DP KR Sbjct: 237 -----------------AEYEFDSPYWDDI-----------SDSAKDFIRNLMEKDPNKR 268 Query: 348 ISVDDALQHPYI 359 + + A +HP+I Sbjct: 269 YTCEQAARHPWI 280 >2HAK-A nrPDB Length = 328 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 82/346 (23%), Positives = 140/346 (40%), Gaps = 55/346 (15%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K IG G V A + R VA+K + + N T ++ +RE+ +MK +NH NI Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQMELDHERMSYLLYQMLCGIKHL 180 + L V +KTL YLVME V + + Q++ +++ Sbjct: 77 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 130 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Y Sbjct: 131 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 241 K-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 VD+WS+G I+ +V + F G++ +K+L+ V Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQN-------------------LKELRERVLRGKY 231 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P Y L L P KR S++ ++ ++ Sbjct: 232 RIPFYMSTDCENLLKKLLVLN-----------------------PIKRGSLEQIMKDRWM 268 Query: 360 NVWYDPAEVEA---PPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 402 NV ++ E++ P P D + + T+ ++ I ++N + Sbjct: 269 NVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQK 314 >6C9D-A nrPDB Length = 459 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 92/403 (22%), Positives = 159/403 (39%), Gaps = 60/403 (14%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K IG G V A + R VA+K + + N T ++ +RE+ +MK +NH NI Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQMELDHERMSYLLYQMLCGIKHL 180 + L V +KTL YLVME V + + Q++ +++ Sbjct: 83 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 136 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 H I+HRDLK N+++ D +KI DFG + + + + Y APE+ G Y Sbjct: 137 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 241 K-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 VD+WS+G I+ +V + F G++ +K+L+ V Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQN-------------------LKELRERVLRGKY 237 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P Y L L P KR S++ ++ ++ Sbjct: 238 RIPFYMSTDCENLLKKLLVLN-----------------------PIKRGSLEQIMKDRWM 274 Query: 360 NVWYDPAEVEA---PPPQIYDKQLDEREHTIEEWKELIYKEVMN--SEEKTKNGVVKGQP 414 NV ++ E++ P P D + + T+ ++ I ++N +E ++ G+ Sbjct: 275 NVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILLGRK 334 Query: 415 SP---SGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLE 454 P G +++ D S T + T SS++ Sbjct: 335 PPEFEGGESLSGEPKERDKEEGKDSKPRSLRFTWSMKTTSSMD 377 >3COM-A nrPDB Length = 314 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 122/302 (40%), Gaps = 54/302 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ +G G+ G V A + VAIK++ ++ + +E+ +M+ + ++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDSPHV 86 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHERMSYLLYQMLCGIKH 179 + + D+++VME A ++ ++ L + ++ +L L G+++ Sbjct: 87 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEY 140 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILGM 238 LH IHRD+K NI++ ++ K+ DFG+A + + T ++ APEVI + Sbjct: 141 LHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 200 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 GY DIWS+G EM K + I + P P F K Sbjct: 201 GYNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK---------- 247 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 +L + D + + LV P +R + LQHP+ Sbjct: 248 --------------------------PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPF 281 Query: 359 IN 360 + Sbjct: 282 VR 283 >2YCR-A nrPDB Length = 323 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 87/317 (27%), Positives = 135/317 (42%), Gaps = 59/317 (18%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA------YRELV 113 + Y K +GSGA G V A++ + VAIK +S+ A+ A E+ Sbjct: 8 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 67 Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQ--VIQMELDHERMSYLL 170 ++K +NH II + N F + +D Y+V+ELM+ L V L Sbjct: 68 ILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF 120 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVK---SDCTLKILDFGLARTAGTSFMMTPYVVTR 227 YQML +++LH GIIHRDLKP N+++ DC +KI DFG ++ G + +M T Sbjct: 121 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 180 Query: 228 YYRAPEVILG---MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y APEV++ GY VD WS+G I+ + F Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------------------ 222 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 ++ + E + +A DL+ K+LV+DP Sbjct: 223 -------------------RTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 263 Query: 345 AKRISVDDALQHPYINV 361 R + ++AL+HP++ Sbjct: 264 KARFTTEEALRHPWLQD 280 >3I6U-A nrPDB Length = 419 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 92/342 (26%), Positives = 148/342 (43%), Gaps = 63/342 (18%) Query: 38 NMSKSKVDNQFYSVEVGDSTF---TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK 94 ++S++KV F+ + V D + + Y K +GSGA G V A++ + VAI+ Sbjct: 109 SLSRNKV-FVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRI 167 Query: 95 LSRPFQNQTHAKRA------YRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 +S+ A+ A E+ ++K +NH II + N F + +D Y+V+EL Sbjct: 168 ISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-------DAEDYYIVLEL 220 Query: 149 MDAN-LCQ--VIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---SDCT 202 M+ L V L YQML +++LH GIIHRDLKP N+++ DC Sbjct: 221 MEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCL 280 Query: 203 LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG---MGYKENVDIWSVGCIMGEMVRH 259 +KI DFG ++ G + +M T Y APEV++ GY VD WS+G I+ + Sbjct: 281 IKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSG 340 Query: 260 KILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFP 319 F ++ + Sbjct: 341 YPPFSEH-------------------------------------RTQVSLKDQITSGKYN 363 Query: 320 ADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 E + +A DL+ K+LV+DP R + ++AL+HP++ Sbjct: 364 FIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >5WAX-A nrPDB Length = 310 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 77/345 (22%), Positives = 136/345 (39%), Gaps = 59/345 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 RY+ ++ IGSG G+ + + VA+K + R + + RE++ + + H Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG---EKIDENVQREIINHRSLRH 66 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGI 177 NII V L +VME L + I + + Q++ G+ Sbjct: 67 PNIIRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGV 120 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDC--TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 + HS + HRDLK N ++ LKI DFG ++++ V T Y APEV+ Sbjct: 121 SYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 180 Query: 236 LGMGYKENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 L Y V D+WS G + M+ F D + K I+++ +Q ++ Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILG--------VQYSI 232 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 +YV + + +DL+S++ V +PA RI++ + Sbjct: 233 PDYVH----------------------------ISPECQDLISRIFVANPATRITIPEIR 264 Query: 355 QHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVM 399 HP+ ++ P + D +++ E E+M Sbjct: 265 NHPWF--------LKNLPADLMDDSTMSKQYEEPEQPMQSMDEIM 301 >5YKS-A nrPDB Length = 377 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 76/328 (23%), Positives = 129/328 (39%), Gaps = 54/328 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y K +G G +V A VA+K + + + ++E+ MK V H NI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME---LDHERMSYLLYQMLCGIKH 179 + L V Q L YL++EL D ++ I L+ + Q++ I + Sbjct: 97 VRLYEVIDTQTKL------YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 180 LHSAGIIHRDLKPSN-IVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 H ++HRDLKP N + + +K+ DFG + +T + Y APE++LG Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 210 Query: 239 GYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y VDIWS+G I+ +V + F + + +++ Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD-------------------- 250 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 T P + + +DL+++ML DP +R S+++ HP Sbjct: 251 -------CKYTVPS---------------HVSKECKDLITRMLQRDPKRRASLEEIENHP 288 Query: 358 YINVWYDPAEVEAPPPQIYDKQLDEREH 385 ++ + P + K L E EH Sbjct: 289 WLQGVDPSPATKYNIPLVSYKNLSEEEH 316 >5KCV-A nrPDB Length = 460 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 123/346 (35%), Gaps = 61/346 (17%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLM 115 + ++ LK +G G G V + R A+K L + + E ++ Sbjct: 157 HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 216 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQ 172 + H + +L F L VME + +R + + Sbjct: 217 QNSRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAE 270 Query: 173 MLCGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYR 230 ++ + +LHS +++RDLK N+++ D +KI DFGL + M + T Y Sbjct: 271 IVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYL 330 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 APEV+ Y VD W +G +M EM+ ++ F +D+ + ++ Sbjct: 331 APEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-------------- 376 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-- 348 + FP + +A+ LLS +L DP +R+ Sbjct: 377 -------------MEEIRFP---------------RTLGPEAKSLLSGLLKKDPKQRLGG 408 Query: 349 ---SVDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 + +QH + VW E + PP + +E Sbjct: 409 GSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 454 >3TAC-A nrPDB Length = 361 Score = 251 bits (640), Expect = 7e-67, Method: Composition-based stats. Identities = 89/408 (21%), Positives = 161/408 (39%), Gaps = 80/408 (19%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT---HAKRAYRE 111 D Y+ + IG G +V + + A+K + + + RE Sbjct: 19 DDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKRE 78 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELD------HE 164 + + H +I+ LL ++ L Y+V E MD +LC I D Sbjct: 79 ASICHMLKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEA 132 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMT 221 S+ + Q+L +++ H IIHRD+KP +++ S +K+ FG+A G S ++ Sbjct: 133 VASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVA 192 Query: 222 P-YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 V T ++ APEV+ Y + VD+W G I+ ++ + F G E+L Sbjct: 193 GGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTK---------ERLF 243 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 + K+ P +++ + A+DL+ +ML Sbjct: 244 EGIIKGKYKMNPRQWSHI------------------------------SESAKDLVRRML 273 Query: 341 VIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN 400 ++DPA+RI+V +AL HP++ Y ++ T+E+ ++ N Sbjct: 274 MLDPAERITVYEALNHPWLKE-----------RDRYAYKI-HLPETVEQLRKF------N 315 Query: 401 SEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASD 448 + K K V+ + S NS PP + ++ LA++ Sbjct: 316 ARRKLKGAVLA---AVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAE 360 >3D2K-A nrPDB Length = 272 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 131/313 (41%), Gaps = 53/313 (16%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYR 110 +G L+ + +P+G G G V A + +A+K L + + + + R Sbjct: 2 PLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRR 61 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM--ELDHERMS 167 E+ + + H NI+ L F VYL++E + + +Q D +R + Sbjct: 62 EVEIQSHLRHPNILRLYGYFHDATR------VYLILEYAPLGTVYRELQKLSRFDEQRTA 115 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 + ++ + + HS +IHRD+KP N+++ S+ LKI DFG + A +S T T Sbjct: 116 TYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSS-RRTTLCGTL 174 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y PE+I G + E VD+WS+G + E + F Y + + ++ Sbjct: 175 DYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV--------- 225 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 TFP ARDL+S++L + ++R Sbjct: 226 ------------------EFTFPDF---------------VTEGARDLISRLLKHNASQR 252 Query: 348 ISVDDALQHPYIN 360 +++ + L+HP+I Sbjct: 253 LTLAEVLEHPWIK 265 >6FD3-A nrPDB Length = 300 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 80/337 (23%), Positives = 148/337 (43%), Gaps = 55/337 (16%) Query: 38 NMSKSKVDNQFYS-VEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS 96 +M+ ++ + S V VGD K+Y + IG GA G V A D + VAIK+++ Sbjct: 1 SMTDEEILEKLRSIVSVGDPK----KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 56 Query: 97 RPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV 156 Q Q + E+++M+ + NI++ L+ + ++++VME + Sbjct: 57 --LQQQPKKELIINEILVMRENKNPNIVNYLDSYLV------GDELWVVMEYLAGGSLTD 108 Query: 157 IQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ART 213 + E +D +++ + + L + LHS +IHRD+K NI++ D ++K+ DFG A+ Sbjct: 109 VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI 168 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 + V T Y+ APEV+ Y VDIWS+G + EMV + + + + Sbjct: 169 TPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALY 228 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQAR 333 + GTP + ++ + ++ R Sbjct: 229 LIATN-GTP--------------------------------------ELQNPERLSAVFR 249 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEA 370 D L++ L +D +R S + LQHP++ + + + Sbjct: 250 DFLNRCLEMDVDRRGSAKELLQHPFLKLDKPLSSLTP 286 >3MV5-A nrPDB Length = 342 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 69/344 (20%), Positives = 123/344 (35%), Gaps = 61/344 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKC 117 + ++ LK +G G G V + R A+K L + + E +++ Sbjct: 7 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 66 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQML 174 H + +L F L VME + +R + +++ Sbjct: 67 SRHPFLTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 120 Query: 175 CGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAP 232 + +LHS +++RDLK N+++ D +KI DFGL + M + T Y AP Sbjct: 121 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP 180 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 EV+ Y VD W +G +M EM+ ++ F +D+ + ++ Sbjct: 181 EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL---------------- 224 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---- 348 + FP + +A+ LLS +L DP +R+ Sbjct: 225 -----------MEEIRFP---------------RTLGPEAKSLLSGLLKKDPKQRLGGGS 258 Query: 349 -SVDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 + +QH + VW E + PP + +E Sbjct: 259 EDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDE 302 >4UZD-A nrPDB Length = 287 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 130/304 (42%), Gaps = 53/304 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYRELVLMKCVN 119 L+ ++ +P+G G G V A + +A+K L + + + + RE+ + + Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM--ELDHERMSYLLYQMLCG 176 H NI+ L F VYL++E + + +Q + D +R + + ++ Sbjct: 67 HPNILRLYGYFHDATR------VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANA 120 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + HS +IHRD+KP N+++ S LKI DFG + A +S T T Y PE+I Sbjct: 121 LSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS-RRTTLCGTLDYLPPEMIE 179 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 G + E VD+WS+G + E + K F Y + + ++ Sbjct: 180 GRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV------------------ 221 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 TFP ARDL+S++L +P++R + + L+H Sbjct: 222 ---------EFTFPDF---------------VTEGARDLISRLLKHNPSQRPMLREVLEH 257 Query: 357 PYIN 360 P+I Sbjct: 258 PWIT 261 >5XZW-A nrPDB Length = 471 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 134/319 (42%), Gaps = 64/319 (20%) Query: 60 VLKRYQNL-KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 + K + + + +G GA V A + + A+K +S+ + + REL +++ + Sbjct: 193 IFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKR-KVIGNMDGVTRELEVLQKL 251 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI--QMELDHERMSYLLYQMLC 175 NH I+ L + E+ + Y+VME + +L + + + + Q+L Sbjct: 252 NHPRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILT 305 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 IK++HS GI HRDLKP NI+++ D +KI DFGLA+ G M + T Y APE Sbjct: 306 AIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPE 365 Query: 234 VILGMG-------------YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 VI G Y VD+WS+GC++ ++ + F G DQ K I + Sbjct: 366 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQDQLYKQIGR-- 422 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 + + + +ARD + +L Sbjct: 423 -----------------------------------GSYHEGPLKDFRISEEARDFIDSLL 447 Query: 341 VIDPAKRISVDDALQHPYI 359 +DP R + AL HP+I Sbjct: 448 QVDPNNRSTAAKALNHPWI 466 >4NIF-A nrPDB Length = 333 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 79/317 (24%), Positives = 138/317 (43%), Gaps = 58/317 (18%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 S Y + IG G+ + A+K + + ++ + E+ + Sbjct: 1 GSNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEI 54 Query: 115 M-KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLL 170 + + H NII+L +V+ ++ + VYLV ELM L ++++ + S++L Sbjct: 55 LLRYGQHPNIITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVL 108 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIV-VKSDCT---LKILDFGLARTA--GTSFMMTPYV 224 + + +++LHS G++HRDLKPSNI+ V L+I DFG A+ +MTP Sbjct: 109 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTP-C 167 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 T + APEV+ GY E DIWS+G ++ M+ F D +++ ++G+ Sbjct: 168 YTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGS--- 223 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 F + + A+DL+SKML +DP Sbjct: 224 -------------------------------GKFTLSGGNWNTVSETAKDLVSKMLHVDP 252 Query: 345 AKRISVDDALQHPYINV 361 +R++ LQHP++ Sbjct: 253 HQRLTAKQVLQHPWVTQ 269 >2W4O-A nrPDB Length = 349 Score = 248 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 82/350 (23%), Positives = 140/350 (40%), Gaps = 67/350 (19%) Query: 28 VDVSYIAKHYN-----------MSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQG 76 VD+ ++ + S V + + D+ + ++ +G GA Sbjct: 11 VDLGTENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDA---LSDFFEVESELGRGATS 67 Query: 77 IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTL 136 IV + A+K L + + E+ ++ ++H NII L +F Sbjct: 68 IVYRCKQKGTQKPYALKVLKKTVDKKIVR----TEIGVLLRLSHPNIIKLKEIFETP--- 120 Query: 137 EEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193 ++ LV+EL+ L I + + + Q+L + +LH GI+HRDLKP Sbjct: 121 ---TEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPE 177 Query: 194 NIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVG 250 N++ + D LKI DFGL++ +M T Y APE++ G Y VD+WSVG Sbjct: 178 NLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVG 237 Query: 251 CIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFP 310 I ++ F + DQ ++ R F Sbjct: 238 IITYILLCGFEPFY-DERGDQ-------------------------FMFRRILNCEYYFI 271 Query: 311 KLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 + D + + A+DL+ K++V+DP KR++ ALQHP++ Sbjct: 272 SPWWDEV-----------SLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >2JDO-A nrPDB Length = 342 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 65/343 (18%), Positives = 124/343 (36%), Gaps = 60/343 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKC 117 + + LK +G G G V + R A+K L + + E +++ Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 66 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQML 174 H + +L F L VME + ER + +++ Sbjct: 67 TRHPFLTALKYAFQTHDRL------CFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 120 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPE 233 +++LHS +++RD+K N+++ D +KI DFGL + M + T Y APE Sbjct: 121 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPE 180 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y VD W +G +M EM+ ++ F +D+ + ++ Sbjct: 181 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL----------------- 223 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI----- 348 + FP + + +A+ LL+ +L DP +R+ Sbjct: 224 ----------MEEIRFP---------------RTLSPEAKSLLAGLLKKDPKQRLGGGPS 258 Query: 349 SVDDALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTIEE 389 + ++H + W D + + PP + ++ Sbjct: 259 DAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDD 301 >4LG4-A nrPDB Length = 299 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 122/302 (40%), Gaps = 54/302 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ +G G+ G V A + VAIK++ ++ + +E+ +M+ + + Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYV 68 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHERMSYLLYQMLCGIKH 179 + + D+++VME A ++ ++ L + ++ +L L G+++ Sbjct: 69 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 122 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILGM 238 LH IHR++K NI++ ++ K+ DFG+A + + T ++ APEVI + Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 182 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 GY DIWS+G EM K + I + P P F K Sbjct: 183 GYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK---------- 229 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 +L + D + K LV +P +R + LQHP+ Sbjct: 230 --------------------------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 263 Query: 359 IN 360 I Sbjct: 264 IK 265 >5D9K-A nrPDB Length = 330 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 134/342 (39%), Gaps = 64/342 (18%) Query: 63 RYQNLKPIGSGAQGIVCAAYDA---VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 +++ LK +G G+ G V + A+K L + R E ++ VN Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVN 90 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERMSYLLYQMLCG 176 H I+ L F + L YL+++ + +L + E E + + L ++ Sbjct: 91 HPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 144 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-TPYVVTRYYRAPEVI 235 + HLHS GII+RDLKP NI++ + +K+ DFGL++ + + T Y APEV+ Sbjct: 145 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 204 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE-QLGTPCPEFMKKLQPTV 294 G+ ++ D WS G +M EM+ + F G+D + +++ +LG P Sbjct: 205 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP------------ 252 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV---- 350 + + +A+ LL + +PA R+ Sbjct: 253 -------------------------------QFLSPEAQSLLRMLFKRNPANRLGAGPDG 281 Query: 351 -DDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 ++ +H + + W E PP E + Sbjct: 282 VEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 323 >4FIE-A nrPDB Length = 423 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 136/303 (44%), Gaps = 50/303 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ + N Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 215 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGII 186 + ++++VME ++ I ++ E+++ + +L + LH+ G+I Sbjct: 216 SYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 269 Query: 187 HRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD 245 HRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y VD Sbjct: 270 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD 329 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYA 305 IWS+G ++ EMV + + + K ++ + P +K L Sbjct: 330 IWSLGIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHK------------- 372 Query: 306 GLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365 + + L ++LV DPA+R + + L+HP++ P Sbjct: 373 ----------------------VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 410 Query: 366 AEV 368 A + Sbjct: 411 ASI 413 >2F57-A nrPDB Length = 317 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 136/301 (45%), Gaps = 50/301 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ GIVC A + + VA+KK+ + Q + + E+V+M+ +H N++ + + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMD--LRKQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGII 186 + ++++VME ++ I ++ E+++ + +L + +LH+ G+I Sbjct: 110 SYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVI 163 Query: 187 HRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD 245 HRD+K +I++ SD +K+ DFG A+ + V T Y+ APEVI + Y VD Sbjct: 164 HRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVD 223 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYA 305 IWS+G ++ EM+ + + + ++ + L Sbjct: 224 IWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL-------------------------- 257 Query: 306 GLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365 P + +S R L MLV +P++R + + L HP++ + P Sbjct: 258 -------------PPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPP 304 Query: 366 A 366 + Sbjct: 305 S 305 >4JDH-A nrPDB Length = 346 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 136/303 (44%), Gaps = 50/303 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ + N Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 138 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGII 186 + ++++VME ++ I ++ E+++ + +L + LH+ G+I Sbjct: 139 SYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 192 Query: 187 HRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD 245 HRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y VD Sbjct: 193 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD 252 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYA 305 IWS+G ++ EMV + + + K ++ + P +K L Sbjct: 253 IWSLGIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHK------------- 295 Query: 306 GLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365 + + L ++LV DPA+R + + L+HP++ P Sbjct: 296 ----------------------VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 333 Query: 366 AEV 368 A + Sbjct: 334 ASI 336 >2JAM-A nrPDB Length = 304 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 74/311 (23%), Positives = 128/311 (41%), Gaps = 53/311 (17%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 T + K + ++ +GSGA V + + A+K + + E+ ++ Sbjct: 3 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK--SPAFRDSSLENEIAVL 60 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQ 172 K + H+NI++L +++ E YLVM+L+ L I + S ++ Q Sbjct: 61 KKIKHENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQ 114 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 +L +K+LH GI+HRDLKP N++ + + + I DFGL++ M+ T Y Sbjct: 115 VLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI-MSTACGTPGY 173 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APEV+ Y + VD WS+G I ++ F + K+ E Sbjct: 174 VAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKE------------ 221 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 F F D + + A+D + +L DP +R + Sbjct: 222 ---------------GYYEFESPFWDDI-----------SESAKDFICHLLEKDPNERYT 255 Query: 350 VDDALQHPYIN 360 + AL HP+I+ Sbjct: 256 CEKALSHPWID 266 >6FDY-U nrPDB Length = 276 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 124/312 (39%), Gaps = 51/312 (16%) Query: 61 LKRYQNLKPIGSGAQGIVCAAY-DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 L + + +GSG V AY VAIK +++ N+ + E+ ++K + Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERMSYLLYQMLCG 176 H +I+ L + + ++YL+ME +L + I L + + Q+ Sbjct: 70 HPHIVQLKDF------QWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASA 123 Query: 177 IKHLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV 234 ++ LH I H DLKP NI++ LK+ DFG A+ + Y APE+ Sbjct: 124 LQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEM 183 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + Y VD+WS+G I+ E + + F R + + K+ P Sbjct: 184 VCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP---------- 233 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 L + RDLL ++L DP++RIS D Sbjct: 234 -----------------------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFF 264 Query: 355 QHPYINVWYDPA 366 HP++++ + P+ Sbjct: 265 AHPWVDLEHMPS 276 >2Q0N-A nrPDB Length = 301 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 136/303 (44%), Gaps = 50/303 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ + N Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 93 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGII 186 + ++++VME ++ I ++ E+++ + +L + LH+ G+I Sbjct: 94 SYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 147 Query: 187 HRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD 245 HRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y VD Sbjct: 148 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD 207 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYA 305 IWS+G ++ EMV + + + K ++ + P +K L Sbjct: 208 IWSLGIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHK------------- 250 Query: 306 GLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365 + + L ++LV DPA+R + + L+HP++ P Sbjct: 251 ----------------------VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 288 Query: 366 AEV 368 A + Sbjct: 289 ASI 291 >2WO6-A nrPDB Length = 382 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 102/380 (26%), Positives = 162/380 (42%), Gaps = 52/380 (13%) Query: 28 VDVSYIAKHY-NMSKSKVDNQFYS-----------VEVGDSTFTVLKRYQNLKPIGSGAQ 75 VD+ ++ +MS K + + Y+ V+ G+ + RY+ IG G+ Sbjct: 11 VDLGTENLYFQSMSSHKKERKVYNDGYDDDNYDYIVKNGEKW---MDRYEIDSLIGKGSF 67 Query: 76 GIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKT 135 G V AYD V VAIK + + +A E+ L++ +N + + ++ Sbjct: 68 GQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRH 124 Query: 136 LEEFQDVYLVMELMDANLCQVIQ----MELDHERMSYLLYQMLCGIKHLH--SAGIIHRD 189 + LV E++ NL +++ + QM + L IIH D Sbjct: 125 FMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCD 184 Query: 190 LKPSNIVVKS--DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIW 247 LKP NI++ + +KI+DFG + G + Y+ +R+YR+PEV+LGM Y +D+W Sbjct: 185 LKPENILLCNPKRSAIKIVDFGSSCQLG--QRIYQYIQSRFYRSPEVLLGMPYDLAIDMW 242 Query: 248 SVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAG- 306 S+GCI+ EM + LF G + +DQ NK++E LG P P + P R + E P Sbjct: 243 SLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP-PAHILDQAPKARKFFEKLPDGTWN 301 Query: 307 ----------------------LTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 L P +S H + +DL+ +ML DP Sbjct: 302 LKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDP 361 Query: 345 AKRISVDDALQHPYINVWYD 364 RI ALQH + D Sbjct: 362 KTRIQPYYALQHSFFKKTAD 381 >4XBR-A nrPDB Length = 366 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 136/303 (44%), Gaps = 50/303 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ GIVC A + VA+KK+ + Q + + E+V+M+ H+N++ + N Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMD--LRKQQRRELLFNEVVIMRDYQHENVVEMYN 158 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGII 186 + ++++VME ++ I ++ E+++ + +L + LH+ G+I Sbjct: 159 SYLV------GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVI 212 Query: 187 HRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD 245 HRD+K +I++ D +K+ DFG A+ + V T Y+ APE+I + Y VD Sbjct: 213 HRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVD 272 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYA 305 IWS+G ++ EMV + + + K ++ + P +K L Sbjct: 273 IWSLGIMVIEMVDGEPPYFNEPPL----KAMKMIRDNLPPRLKNLHK------------- 315 Query: 306 GLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365 + + L ++LV DPA+R + + L+HP++ P Sbjct: 316 ----------------------VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPP 353 Query: 366 AEV 368 A + Sbjct: 354 ASI 356 >6AO5-A nrPDB Length = 362 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 122/302 (40%), Gaps = 54/302 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ +G G+ G V A + VAIK++ ++ + +E+ +M+ + + Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDSPYV 67 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHERMSYLLYQMLCGIKH 179 + + D+++VME A ++ ++ L + ++ +L L G+++ Sbjct: 68 VKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEY 121 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILGM 238 LH IHR++K NI++ ++ K+ DFG+A + + T ++ APEVI + Sbjct: 122 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 181 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 GY DIWS+G EM K + I + P P F K Sbjct: 182 GYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK---------- 228 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 +L + D + K LV +P +R + LQHP+ Sbjct: 229 --------------------------PELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 262 Query: 359 IN 360 I Sbjct: 263 IK 264 >4CQG-A nrPDB Length = 331 Score = 244 bits (624), Expect = 5e-65, Method: Composition-based stats. Identities = 78/325 (24%), Positives = 133/325 (40%), Gaps = 56/325 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 +LK Y+ + IG+G V A + VAIK + + + R E+ +K + Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG-SDLPRVKTEIDALKSL 64 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLC 175 H++I L +V LE +++V+E L I Q L E + Q+L Sbjct: 65 RHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILS 118 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTRYYRAPE 233 + ++HS G HRDLKP N++ + LK++DFGL + + + Y APE Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 234 VILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 +I G Y D+WS+G ++ ++ + F + + + K++ Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMR--------------- 223 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 E K + + LL +ML +DP KRIS+ + Sbjct: 224 ---------------------------GKYEVPKWLSPSSILLLQQMLQVDPKKRISMRN 256 Query: 353 ALQHPYINVWYD-PAEVEAPPPQIY 376 L HP++ Y P E ++ P + Sbjct: 257 LLNHPWVMQDYSCPVEWQSKTPLTH 281 >2J90-A nrPDB Length = 304 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 125/312 (40%), Gaps = 55/312 (17%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA----KRAYRELVLM 115 V Y+ + +GSG IV + A K + + + + + RE+ ++ Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQ 172 + + H NII+L ++F E DV L++EL+ L + + L + + L Q Sbjct: 84 REIRHPNIITLHDIF------ENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQ 137 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKS----DCTLKILDFGLARTAGTSFMMTPYVVTRY 228 +L G+ +LHS I H DLKP NI++ + +K++DFG+A T Sbjct: 138 ILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPE 197 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 + APE++ D+WS+G I ++ F G + + Sbjct: 198 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV---------- 247 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 + D E+ + A+D + ++LV DP +R+ Sbjct: 248 ----------------------------NYDFDEEYFSNTSELAKDFIRRLLVKDPKRRM 279 Query: 349 SVDDALQHPYIN 360 ++ +L+H +I Sbjct: 280 TIAQSLEHSWIK 291 >4JG6-A nrPDB Length = 355 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 80/366 (21%), Positives = 151/366 (41%), Gaps = 66/366 (18%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM- 115 + Y+ + IG G+ + + A+K + + ++ T E+ ++ Sbjct: 30 SIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------EIEILL 83 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMEL-DHERMSYLLYQ 172 + H NII+L +V+ ++ + VY+V ELM L ++++ + S +L+ Sbjct: 84 RYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFT 137 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIV-VKSDCT---LKILDFGLARTA--GTSFMMTPYVVT 226 + +++LH+ G++HRDLKPSNI+ V ++I DFG A+ +MTP T Sbjct: 138 ITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP-CYT 196 Query: 227 RYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 + APEV+ GY DIWS+G ++ M+ F D +++ ++G+ Sbjct: 197 ANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGS----- 250 Query: 287 MKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 F + + A+DL+SKML +DP + Sbjct: 251 -----------------------------GKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQ 281 Query: 347 RISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTK 406 R++ L+HP+I W + Y + H ++ Y + ++ Sbjct: 282 RLTAALVLRHPWIVHWDQLPQ--------YQLNRQDAPHLVKGAMAATYSALNRNQSPVL 333 Query: 407 NGVVKG 412 V + Sbjct: 334 EPVGRS 339 >2YZA-A nrPDB Length = 276 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 115/306 (37%), Gaps = 53/306 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 + Y +G G G V + VA+K L+R ++ + RE+ +K Sbjct: 10 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 69 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCG 176 H +II L V + D ++VME + L I ++ L Q+L Sbjct: 70 HPHIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSA 123 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + + H ++HRDLKP N+++ + KI DFGL+ + + Y APEVI Sbjct: 124 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVIS 183 Query: 237 GMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G Y VDIWS G I+ ++ + F E + L +R Sbjct: 184 GRLYAGPEVDIWSCGVILYALLCGTLPFD-------------------DEHVPTLFKKIR 224 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 V P+Y + LL ML +DP KR ++ D + Sbjct: 225 GGVFYIPEYLNRSVAT-----------------------LLMHMLQVDPLKRATIKDIRE 261 Query: 356 HPYINV 361 H + Sbjct: 262 HEWFKQ 267 >1KOB-A nrPDB Length = 387 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 70/361 (19%), Positives = 143/361 (39%), Gaps = 53/361 (14%) Query: 37 YNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS 96 Y+ + ++ V +V Y L+ +GSGA G+V + R K ++ Sbjct: 26 YDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFIN 85 Query: 97 RPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQ 155 P+ + E+ +M ++H +I+L + F + ++ L++E + L Sbjct: 86 TPYPLDKY--TVKNEISIMNQLHHPKLINLHDAFEDKY------EMVLILEFLSGGELFD 137 Query: 156 VI---QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGL 210 I ++ + + Q G+KH+H I+H D+KP NI+ ++ ++KI+DFGL Sbjct: 138 RIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGL 197 Query: 211 ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 A ++ T + APE++ D+W++G + ++ F G D ++ Sbjct: 198 ATKLNPDEIVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLE 257 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 ++ + E+ + Sbjct: 258 TLQ---------------NVKRCDWEFDED-----------------------AFSSVSP 279 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEW 390 +A+D + +L +P KR++V DAL+HP++ + P Y+K + + +W Sbjct: 280 EAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSRI-PSSRYNKIRQKIKEKYADW 338 Query: 391 K 391 Sbjct: 339 P 339 >4KS7-A nrPDB Length = 292 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 135/301 (44%), Gaps = 50/301 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ GIVC A + R VA+K + + Q + + E+V+M+ H N++ + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD--LRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYLLYQMLCGIKHLHSAGII 186 + ++++++ME + I Q+ L+ E+++ + +L + +LH+ G+I Sbjct: 88 SYLV------GEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 187 HRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVD 245 HRD+K +I++ D +K+ DFG A+ + V T Y+ APEVI Y VD Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVD 201 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYA 305 IWS+G ++ EMV + + + D + +++L P +K Sbjct: 202 IWSLGIMVIEMVDGEPPY----FSDSPVQAMKRLRDSPPPKLKN---------------- 241 Query: 306 GLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP 365 + + RD L +MLV DP +R + + L HP++ P Sbjct: 242 -------------------SHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLP 282 Query: 366 A 366 Sbjct: 283 E 283 >4L42-A nrPDB Length = 346 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 73/341 (21%), Positives = 127/341 (37%), Gaps = 64/341 (18%) Query: 64 YQNLKPIGSGAQGIVCAAYDAV---LDRNVAIKKLSRPF--QNQTHAKRAYRELVLMKCV 118 ++ L+ +G G G V + A+K L + +N E +++ V Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 79 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 175 H I+ L+ F L YL++E + L ++ E + + L ++ Sbjct: 80 KHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 133 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEV 234 + HLH GII+RDLKP NI++ +K+ DFGL + + + T Y APE+ Sbjct: 134 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 193 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 ++ G+ VD WS+G +M +M+ F G + +K+++ P Sbjct: 194 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYL-------- 245 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----S 349 +ARDLL K+L + A R+ Sbjct: 246 ----------------------------------TQEARDLLKKLLKRNAASRLGAGPGD 271 Query: 350 VDDALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTIE 388 + HP+ W + + PP Q +E + Sbjct: 272 AGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFD 312 >2Z7Q-A nrPDB Length = 321 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 131/328 (39%), Gaps = 64/328 (19%) Query: 64 YQNLKPIGSGAQGIVCAAYDA---VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ LK +G G+ G V A+K L + R E ++ VNH Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 89 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERMSYLLYQMLCGI 177 ++ L F + L YL+++ + +L + E E + + L ++ G+ Sbjct: 90 PFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGL 143 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-TPYVVTRYYRAPEVIL 236 HLHS GII+RDLKP NI++ + +K+ DFGL++ A + T Y APEV+ Sbjct: 144 DHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVN 203 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE-QLGTPCPEFMKKLQPTVR 295 G+ + D WS G +M EM+ + F G+D + +++ +LG P Sbjct: 204 RQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP------------- 250 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SV 350 + +++A+ LL + +PA R+ Sbjct: 251 ------------------------------QFLSTEAQSLLRALFKRNPANRLGSGPDGA 280 Query: 351 DDALQHPYIN--VWYDPAEVEAPPPQIY 376 ++ +H + + W E PP Sbjct: 281 EEIKRHVFYSTIDWNKLYRREIKPPFKP 308 >4RLP-A nrPDB Length = 288 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 123/329 (37%), Gaps = 64/329 (19%) Query: 64 YQNLKPIGSGAQGIVCAAYDAV---LDRNVAIKKLSRPF--QNQTHAKRAYRELVLMKCV 118 ++ L+ +G G G V + A+K L + +N E +++ V Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLC 175 H I+ L+ F L YL++E + L ++ E + + L ++ Sbjct: 67 KHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM 120 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEV 234 + HLH GII+RDLKP NI++ +K+ DFGL + + + T Y APE+ Sbjct: 121 ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 180 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 ++ G+ VD WS+G +M +M+ F G + +K+++ P Sbjct: 181 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYL-------- 232 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----S 349 +ARDLL K+L + A R+ Sbjct: 233 ----------------------------------TQEARDLLKKLLKRNAASRLGAGPGD 258 Query: 350 VDDALQHPYINV--WYDPAEVEAPPPQIY 376 + HP+ W + + PP Sbjct: 259 AGEVQAHPFFRHINWEELLARKVEPPFKP 287 >4D2V-A nrPDB Length = 356 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 78/325 (24%), Positives = 130/325 (40%), Gaps = 56/325 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 +LK Y+ + IG+G V A + VAIK + + + R E+ +K + Sbjct: 26 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEALKNL 84 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLC 175 H++I L +V LE +++V+E L I Q L E + Q++ Sbjct: 85 RHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVS 138 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTRYYRAPE 233 + ++HS G HRDLKP N++ LK++DFGL + + Y APE Sbjct: 139 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE 198 Query: 234 VILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 +I G Y D+WS+G ++ ++ + F K++ Sbjct: 199 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMR--------------- 243 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 + K + + LL +ML +DP KRIS+ + Sbjct: 244 ---------------------------GKYDVPKWLSPSSILLLQQMLQVDPKKRISMKN 276 Query: 353 ALQHPYINVWYD-PAEVEAPPPQIY 376 L HP+I Y+ P E ++ P I+ Sbjct: 277 LLNHPWIMQDYNYPVEWQSKNPFIH 301 >3ZUT-A nrPDB Length = 362 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 77/339 (22%), Positives = 131/339 (38%), Gaps = 51/339 (15%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 RY+ +K IGSG G+ D + VA+K + R + + RE++ + + H Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG---EKIDENVKREIINHRSLRHP 75 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIK 178 NI+ V L +VME L + I + + Q++ G+ Sbjct: 76 NIVRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 Query: 179 HLHSAGIIHRDLKPSNIVVKSDC--TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + H+ + HRDLK N ++ LKI FG ++++ V T Y APEV+L Sbjct: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 Query: 237 GMGYKENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y V D+WS G + M+ F + + K I ++ +Q + Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIP 241 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 +YV + + R L+S++ V DPAKRIS+ + Sbjct: 242 DYVH----------------------------ISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELI 394 H + + + D+ +IEE ++I Sbjct: 274 HEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQII 312 >5JZN-A nrPDB Length = 280 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 80/323 (24%), Positives = 136/323 (42%), Gaps = 56/323 (17%) Query: 50 SVEVGDSTF----TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 EV + F T+ +RY+ + IG G +V + R A+K + + Sbjct: 3 GEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEH 62 Query: 106 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM--ELD 162 E+ +++ V H NI+ L+ ++ ++YLVMEL+ +L I + Sbjct: 63 M-IQNEVSILRRVKHPNIVLLIE------EMDVPTELYLVMELVKGGDLFDAITSTNKYT 115 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV----KSDCTLKILDFGLARTAGTSF 218 S +LY + IK+LHS I+HRD+KP N++V +LK+ DFGLA Sbjct: 116 ERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DG 173 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 + T Y APE+I GY VDIW+ G I ++ F G Sbjct: 174 PLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGD---------- 223 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 + + ++ + FP + D++ + A++L++ Sbjct: 224 ---------------DQEVLFDQILMGQVDFPSPYWDNV-----------SDSAKELITM 257 Query: 339 MLVIDPAKRISVDDALQHPYINV 361 ML++D +R S L+HP++N Sbjct: 258 MLLVDVDQRFSAVQVLEHPWVND 280 >3Q53-A nrPDB Length = 306 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 80/336 (23%), Positives = 147/336 (43%), Gaps = 55/336 (16%) Query: 39 MSKSKVDNQFYS-VEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 MS ++ + S V VGD K+Y + IG GA G V A D + VAI++++ Sbjct: 1 MSDEEILEKLRSIVSVGDPK----KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN- 55 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 157 Q Q + E+++M+ + NI++ L+ + ++++VME + + Sbjct: 56 -LQQQPKKELIINEILVMRENKNPNIVNYLDSYLV------GDELWVVMEYLAGGSLTDV 108 Query: 158 QME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTA 214 E +D +++ + + L ++ LHS +IHRD+K NI++ D ++K+ DFG A+ Sbjct: 109 VTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 168 Query: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK 274 + V T Y+ APEV+ Y VDIWS+G + EM+ + + + + Sbjct: 169 PEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYL 228 Query: 275 VIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD 334 + GTP + +KL ++ RD Sbjct: 229 IATN-GTPELQNPEKL--------------------------------------SAIFRD 249 Query: 335 LLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEA 370 L++ L +D KR S + +QH ++ + + + Sbjct: 250 FLNRCLEMDVEKRGSAKELIQHQFLKIAKPLSSLTP 285 >3UDB-A nrPDB Length = 317 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 77/339 (22%), Positives = 131/339 (38%), Gaps = 51/339 (15%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 RY+ +K IG+G G+ D + VA+K + R + + RE++ + + H Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG---EKIDENVKREIINHRSLRHP 75 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIK 178 NI+ V L +VME L + I + + Q++ G+ Sbjct: 76 NIVRFKEVILTPTHLA------IVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 Query: 179 HLHSAGIIHRDLKPSNIVVKSDC--TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + H+ + HRDLK N ++ LKI DFG ++ + V T Y APEV+L Sbjct: 130 YAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLL 189 Query: 237 GMGYKENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y V D+WS G + M+ F + + K I ++ +Q + Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI--------LNVQYAIP 241 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 +YV + + R L+S++ V DPAKRIS+ + Sbjct: 242 DYVH----------------------------ISPECRHLISRIFVADPAKRISIPEIRN 273 Query: 356 HPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELI 394 H + + + D+ +IEE ++I Sbjct: 274 HEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEEIMQII 312 >4PDS-A nrPDB Length = 347 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 79/321 (24%), Positives = 134/321 (41%), Gaps = 64/321 (19%) Query: 60 VLKRYQNL-KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 + K + + + +G GA V A + + ++K +S+ + + REL +++ + Sbjct: 28 IFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKR-KVIGNMDGVTRELEVLQKL 86 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI--QMELDHERMSYLLYQMLC 175 NH I+ L + E+ + Y+VME + +L + + + + Q+L Sbjct: 87 NHPRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILT 140 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 IK++HS GI HRDLKP NI+++ D +KI FGLA+ G M + T Y APE Sbjct: 141 AIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPE 200 Query: 234 VILGMG-------------YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 VI G Y VD+WS+GC++ ++ + F G DQ K I + Sbjct: 201 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQDQLYKQIGR-- 257 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 + + + +ARD + +L Sbjct: 258 -----------------------------------GSYHEGPLKDFRISEEARDFIDSLL 282 Query: 341 VIDPAKRISVDDALQHPYINV 361 +DP R + AL HP+I + Sbjct: 283 QVDPNNRSTAAKALNHPWIKM 303 >3F3Z-A nrPDB Length = 277 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 79/314 (25%), Positives = 124/314 (39%), Gaps = 53/314 (16%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV 113 G + + + Y IG G+ G V A A KK+ + F R +E+ Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFV--EDVDRFKQEIE 58 Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQME-LDHERMSYLL 170 +MK ++H NII L F E+ D+YLVMEL +V+ + ++ Sbjct: 59 IMKSLDHPNIIRLYETF------EDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIM 112 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 +L + + H + HRDLKP N + D LK++DFGLA MM V T Sbjct: 113 KDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTP 172 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 YY +P+V+ G+ Y D WS G +M ++ F + K+ E Sbjct: 173 YYVSPQVLEGL-YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIRE---------- 221 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 TFP+ ++ + QA L+ ++L P +R Sbjct: 222 -----------------GTFTFPEKDWLNV-----------SPQAESLIRRLLTKSPKQR 253 Query: 348 ISVDDALQHPYINV 361 I+ AL+H + Sbjct: 254 ITSLQALEHEWFEK 267 >2UV2-A nrPDB Length = 325 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 72/375 (19%), Positives = 139/375 (37%), Gaps = 70/375 (18%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87 VD+ ++ K + + ++ F ++ + +G GA G V A + Sbjct: 11 VDLGTENLYFQSMKQY---EHVTRDLNPEDF-----WEIIGELGDGAFGKVYKAQNKETS 62 Query: 88 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 147 A K + +++ + E+ ++ +H NI+ LL+ F + ++++++E Sbjct: 63 VLAAAKVIDT--KSEEELEDYMVEIDILASCDHPNIVKLLDAFYYE------NNLWILIE 114 Query: 148 LMDANLCQV----IQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 ++ L ++ + Q L + +LH IIHRDLK NI+ D + Sbjct: 115 FCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDI 174 Query: 204 KILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMV 257 K+ DFG+ A+ T ++ T Y+ APEV++ Y D+WS+G + EM Sbjct: 175 KLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMA 234 Query: 258 RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSL 317 + + + K+ + Sbjct: 235 EIEPPHHELNPMRVLLKIAKS--------------------------------------- 255 Query: 318 FPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYD 377 P +S +D L K L + R + LQHP++ V + P ++ Sbjct: 256 EPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTV-----DSNKPIRELIA 310 Query: 378 KQLDEREHTIEEWKE 392 + E +E+ KE Sbjct: 311 EAKAEVTEEVEDGKE 325 >1FOT-A nrPDB Length = 318 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 127/310 (40%), Gaps = 59/310 (19%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVN 119 L+ +Q L+ +G+G+ G V R A+K L + + E +++ V Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCG 176 H II + F ++ Q ++++M+ ++ L +++ + + ++ Sbjct: 65 HPFIIRMWGTF------QDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLA 118 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 +++LHS II+RDLKP NI++ + +KI DFG A+ + T Y APEV+ Sbjct: 119 LEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVS 176 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y +++D WS G ++ EM+ F + + + K++ Sbjct: 177 TKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILN------------------- 217 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SVD 351 A L FP F +DLLS+++ D ++R+ + Sbjct: 218 --------AELRFPPFF---------------NEDVKDLLSRLITRDLSQRLGNLQNGTE 254 Query: 352 DALQHPYINV 361 D HP+ Sbjct: 255 DVKNHPWFKE 264 >3IS5-A nrPDB Length = 285 Score = 240 bits (613), Expect = 9e-64, Method: Composition-based stats. Identities = 82/328 (25%), Positives = 135/328 (41%), Gaps = 66/328 (20%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +N ++ + D + + +GSGA G V + IK +++ ++Q Sbjct: 12 ENLYFQGTIDDL-------FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVP 63 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQME-- 160 ++ E+ ++K ++H NII + VF E++ ++Y+VME + L +++ + Sbjct: 64 MEQIEAEIEVLKSLDHPNIIKIFEVF------EDYHNMYIVMETCEGGELLERIVSAQAR 117 Query: 161 ---LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTA 214 L ++ L+ QM+ + + HS ++H+DLKP NI+ + +KI+DFGLA Sbjct: 118 GKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELF 177 Query: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK 274 + T T Y APEV DIWS G +M ++ + F G Sbjct: 178 KSDEHSTNAAGTALYMAPEV-FKRDVTFKCDIWSAGVVMYFLLTGCLPFTG--------- 227 Query: 275 VIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQAR 333 T E +K NY VE RP QA Sbjct: 228 ------TSLEEVQQKATYKEPNYAVECRP-------------------------LTPQAV 256 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINV 361 DLL +ML DP +R S L H + Sbjct: 257 DLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2YAB-A nrPDB Length = 361 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 122/313 (38%), Gaps = 55/313 (17%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA----KRAYRELVLM 115 V Y + +GSG IV + A K + + + + RE+ ++ Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQ 172 + V H NII+L +V+ E DV L++EL+ L + + L E + + Q Sbjct: 70 RQVLHPNIITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDC----TLKILDFGLARTAGTSFMMTPYVVTRY 228 +L G+ +LH+ I H DLKP NI++ +K++DFGLA T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 + APE++ D+WS+G I ++ F G + + Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---------- 233 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 + D E + A+D + K+LV + KR+ Sbjct: 234 ----------------------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRL 265 Query: 349 SVDDALQHPYINV 361 ++ +AL+HP+I Sbjct: 266 TIQEALRHPWITP 278 >4B6L-A nrPDB Length = 281 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 122/315 (38%), Gaps = 53/315 (16%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH-AKRAYRELVLMKCVN 119 + Y + +G G A D A+K + + + H ++ E+ L + + Sbjct: 8 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ 67 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCG 176 H++I+ E+ ++Y+ +EL +L + + L + Y L Q+L G Sbjct: 68 HRHIVRF------SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSG 121 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVI 235 +K+LH GI+HRDLK N + + LK+ DFGLA R T Y APEV+ Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL 181 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 L G+ D+WS+GC+M ++ F D + + + Sbjct: 182 LRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCI-------------------- 221 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 K T P + AR LL+ +L P R S+D L+ Sbjct: 222 -------KQVHYTLPA---------------SLSLPARQLLAAILRASPRDRPSIDQILR 259 Query: 356 HPYINVWYDPAEVEA 370 H + Y P + Sbjct: 260 HDFFTKGYTPDRLPI 274 >3GUB-A nrPDB Length = 295 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 55/314 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA----KRAYRELVL 114 V Y + +GSG +V + A K + + + + RE+ + Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLY 171 +K + H N+I+L V+ E DV L+ EL+ L + + L E + L Sbjct: 68 LKEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLK 121 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT----LKILDFGLARTAGTSFMMTPYVVTR 227 Q+L G+ +LHS I H DLKP NI++ +KI+DFGLA T Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 + APE++ D+WS+G I ++ F G + V Sbjct: 182 EFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV--------- 232 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 + + E+ ++ A+D + ++LV DP KR Sbjct: 233 -----------------------------NYEFEDEYFSNTSALAKDFIRRLLVKDPKKR 263 Query: 348 ISVDDALQHPYINV 361 +++ D+LQHP+I Sbjct: 264 MTIQDSLQHPWIKP 277 >3UC3-A nrPDB Length = 361 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 116/304 (38%), Gaps = 51/304 (16%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 RY +K IGSG G+ D + VA+K + R + RE++ + + H Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA---AIDENVQREIINHRSLRHP 76 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIK 178 NI+ V L ++ME L + I + + Q+L G+ Sbjct: 77 NIVRFKEVILTPTHLA------IIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 Query: 179 HLHSAGIIHRDLKPSNIVVKSDC--TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL 236 + HS I HRDLK N ++ LKI DFG ++++ V T Y APEV+L Sbjct: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 Query: 237 GMGYKEN-VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 Y D+WS G + M+ F + + K I+++ Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI---------------- 234 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 L+ PD + + + L+S++ V DPA RIS+ + Sbjct: 235 -----------LSVKYSIPDDI---------RISPECCHLISRIFVADPATRISIPEIKT 274 Query: 356 HPYI 359 H + Sbjct: 275 HSWF 278 >4I6B-A nrPDB Length = 308 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 132/317 (41%), Gaps = 53/317 (16%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH-AKRAYRELVLMKC 117 T KRY K +G G D ++ A K + ++ H ++ +E+ L + Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRI 84 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--LDHERMSYLLYQML 174 ++HK+++ + F E+ +++Y+++E ++ +++ L + Y L Q++ Sbjct: 85 LHHKHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIV 138 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPE 233 G+K+LH I+HRDLK N + LK+ DFGL AR T Y +PE Sbjct: 139 SGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPE 198 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ G+ DIW++GC+M M+ + F + + + + E Sbjct: 199 VLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIRE---------------- 242 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 A T P + A+ L++ ML +P R S+DD Sbjct: 243 -----------ARYTMPSSLL---------------APAKHLIASMLSKNPEDRPSLDDI 276 Query: 354 LQHPYINVWYDPAEVEA 370 ++H + + P + + Sbjct: 277 IRHDFFTQGFTPDRLSS 293 >3HDN-A nrPDB Length = 373 Score = 238 bits (606), Expect = 6e-63, Method: Composition-based stats. Identities = 82/383 (21%), Positives = 137/383 (35%), Gaps = 63/383 (16%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYREL-VLMKCVNH 120 + LK IG G+ G V A + A+K L + + K E VL+K V H Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGI 177 ++ L F +Y V++ ++ L +Q E R + ++ + Sbjct: 99 PFLVGLHFSFQT------ADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASAL 152 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEVIL 236 +LHS I++RDLKP NI++ S + + DFGL + T + T Y APEV+ Sbjct: 153 GYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 212 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y VD W +G ++ EM+ F R+ + ++ ++ + P Sbjct: 213 KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKP------------ 260 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD----D 352 + AR LL +L D KR+ + Sbjct: 261 ------------------------------NITNSARHLLEGLLQKDRTKRLGAKDDFME 290 Query: 353 ALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVV 410 H + ++ W D + PP + + E + V N+ K + V+ Sbjct: 291 IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFD--PEFTEEPVPNAIGKAPDSVL 348 Query: 411 KGQPSPSGA-AVNSSESLPPSSS 432 A A PP+ S Sbjct: 349 VTASVKEAAEAFLGFSYAPPTDS 371 >1PHK-A nrPDB Length = 298 Score = 238 bits (606), Expect = 6e-63, Method: Composition-based stats. Identities = 72/324 (22%), Positives = 126/324 (38%), Gaps = 61/324 (18%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-------RPFQNQTHAKRA 108 ST + Y+ + +G G +V + A+K + + Q + Sbjct: 11 STHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREAT 70 Query: 109 YRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI--QMELDHE 164 +E+ +++ V+ H NII L + + +LV +LM L + ++ L + Sbjct: 71 LKEVDILRKVSGHPNIIQLKDTYETNTFF------FLVFDLMKKGELFDYLTEKVTLSEK 124 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 224 ++ +L I LH I+HRDLKP NI++ D +K+ DFG + + Sbjct: 125 ETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVC 184 Query: 225 VTRYYRAPEVI------LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 T Y APE+I GY + VD+WS G IM ++ F R + ++ Sbjct: 185 GTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG 244 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 NY P++ + +DL+S+ Sbjct: 245 -----------------NYQFGSPEWDDY---------------------SDTVKDLVSR 266 Query: 339 MLVIDPAKRISVDDALQHPYINVW 362 LV+ P KR + ++AL HP+ + Sbjct: 267 FLVVQPQKRYTAEEALAHPFFQQY 290 >2Y7J-A nrPDB Length = 365 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 126/318 (39%), Gaps = 60/318 (18%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS------RPFQNQTHAKRAYREL 112 ++Y IG G +V A+K + P Q + + RE Sbjct: 91 EFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRET 150 Query: 113 VLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI--QMELDHERMSY 168 +++ V H +II+L++ + E ++LV +LM L + ++ L + Sbjct: 151 HILRQVAGHPHIITLIDSY------ESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRS 204 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 ++ +L + LH+ I+HRDLKP NI++ + +++ DFG + + T Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 229 YRAPEVILGM------GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 Y APE++ GY + VD+W+ G I+ ++ F R I ++E Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME----- 319 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 F D ++S +DL+S++L + Sbjct: 320 ----------------------GQYQFSSPEWDD-----------RSSTVKDLISRLLQV 346 Query: 343 DPAKRISVDDALQHPYIN 360 DP R++ + ALQHP+ Sbjct: 347 DPEARLTAEQALQHPFFE 364 >4CSV-A nrPDB Length = 275 Score = 237 bits (605), Expect = 8e-63, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 106/256 (41%), Gaps = 24/256 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + +GSG G V + VA+K L + + +E +MK + H N++ Sbjct: 14 TLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIMKKLKHPNLV 70 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM----ELDHERMSYLLYQMLCGIKH 179 L V T + +Y++ E M +L ++ ++ + + + Q+ G+ + Sbjct: 71 QLYGVCTKEPP------IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAY 124 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYRAPEVIL 236 L S IHRDL N +V + +K+ DFGLAR T + APE I Sbjct: 125 LESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDE-YTARAGAKFPIKWTAPEAIS 183 Query: 237 GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMKKLQ 291 + D+W+ G ++ E+ ++ +PG + +V P CPE + +L Sbjct: 184 YNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELM 243 Query: 292 PTVRNY-VENRPKYAG 306 N E RP +A Sbjct: 244 LQCWNKSPEERPTFAE 259 >6O6Q-A nrPDB Length = 335 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 152/325 (46%), Gaps = 21/325 (6%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 S ++ + + + + Y+ L+ +G G V D V IK L Sbjct: 21 STKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK----- 75 Query: 102 QTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME 160 K+ RE+ ++K + + NII++L+V ++ + L+ E ++ + + Sbjct: 76 PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQS----KTPGLIFEHINNIDFRSLYPT 131 Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFM 219 + + +Y++L + + HS GI+HRD+KP N+++ D L+++D+GLA Sbjct: 132 FTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTE 191 Query: 220 MTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEM-VRHKILFPGRDYIDQWNKVIE 277 V +RY++ PE+++ Y ++D+WS GC++ M + F G+ DQ +++ Sbjct: 192 YNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVR 251 Query: 278 QLGT-PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 336 LG+ ++++K ++ E+ Y + + + + L + + DL+ Sbjct: 252 VLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFM-------NENNKDLVSQEFLDLI 304 Query: 337 SKMLVIDPAKRISVDDALQHPYINV 361 ++L D +R++ +A++H Y + Sbjct: 305 DRLLRYDHQERLTAKEAMKHAYFDP 329 >5X8I-B nrPDB Length = 346 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 82/329 (24%), Positives = 145/329 (44%), Gaps = 37/329 (11%) Query: 63 RYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-- 119 RY+ + +G GA G V D R+VA+K + + + A E+ +++ +N Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNV---DRYCEAARSEIQVLEHLNTT 70 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLC 175 N S + E + +V EL+ + I+ + + + YQ+ Sbjct: 71 DPN--STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKS-------------------DCTLKILDFGLARTAGT 216 + LHS + H DLKP NI+ + +K++DFG A Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDE 188 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 + V TR+YRAPEVIL +G+ + D+WS+GCI+ E +FP D + ++ Sbjct: 189 HH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLA-MM 245 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH---NKLKASQAR 333 E++ P P+ M + + + +R + + + E ++ + Sbjct: 246 ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLF 305 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINVW 362 DL+ KML DPAKRI++ +AL+HP+ ++ Sbjct: 306 DLIQKMLEYDPAKRITLREALKHPFFDLL 334 >5D7A-A nrPDB Length = 308 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 121/310 (39%), Gaps = 55/310 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKN 122 ++ ++ +G+G G V + AIK + + K+ E+ ++K +H+N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQ---EINMLKKYSHHRN 75 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----LDHERMSYLLYQMLCGI 177 I + F + ++LVME ++ +I+ L E ++Y+ ++L G+ Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVIL 236 HLH +IHRD+K N+++ + +K++DFG++ + ++ T Y+ APEVI Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 Y D+WS+G EM + + Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN------------- 242 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 PA +K + + + + LV + ++R + + Sbjct: 243 ---------------------------PAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 275 Query: 352 DALQHPYINV 361 ++HP+I Sbjct: 276 QLMKHPFIRD 285 >3TXO-A nrPDB Length = 353 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 65/370 (17%), Positives = 122/370 (32%), Gaps = 64/370 (17%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 + + + V S + ++ ++ +G G+ G V A A+K L + Sbjct: 3 KESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVIL 62 Query: 102 QTHAKRA-YRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-- 157 Q E ++ NH + L F L + VME ++ Sbjct: 63 QDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRL------FFVMEFVNGGDLMFHIQ 116 Query: 158 -QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AG 215 D R + +++ + LH GII+RDLK N+++ + K+ DFG+ + Sbjct: 117 KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGIC 176 Query: 216 TSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 + T Y APE++ M Y VD W++G ++ EM+ F + D + + Sbjct: 177 NGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI 236 Query: 276 IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDL 335 + + + A + Sbjct: 237 LN------------------------------------------DEVVYPTWLHEDATGI 254 Query: 336 LSKMLVIDPAKRI-SVDD-----ALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTI 387 L + +P R+ S+ L+HP+ W + PP + E Sbjct: 255 LKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNF 314 Query: 388 EEWKELIYKE 397 + + I +E Sbjct: 315 D--PDFIKEE 322 >4JXF-A nrPDB Length = 266 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 126/306 (41%), Gaps = 54/306 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVN 119 ++ ++ +G G+ V A VAIK + + +R E+ + + Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME---LDHERMSYLLYQMLC 175 H +I+ L N F E+ VYLV+E+ + + + ++ + ++Q++ Sbjct: 66 HPSILELYNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIIT 119 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEV 234 G+ +LHS GI+HRDL SN+++ + +KI DFGLA T Y +PE+ Sbjct: 120 GMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI 179 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + D+WS+GC+ ++ + F + NKV+ Sbjct: 180 ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV------------------ 221 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 AD E + +A+DL+ ++L +PA R+S+ L Sbjct: 222 ------------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVL 257 Query: 355 QHPYIN 360 HP+++ Sbjct: 258 DHPFMS 263 >5F9E-A nrPDB Length = 353 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 79/325 (24%), Positives = 135/325 (41%), Gaps = 57/325 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKCV- 118 ++ ++ K +G G+ G V A ++ AIK L + + E ++ Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERMSYLLYQMLC 175 H + + F ++ L + VME ++ +L IQ + D R ++ +++ Sbjct: 78 EHPFLTHMFCTFQTKENL------FFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIIL 131 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPEV 234 G++ LHS GI++RDLK NI++ D +KI DFG+ + T + T Y APE+ Sbjct: 132 GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEI 191 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 +LG Y +VD WS G ++ EM+ + F G+D + ++ + Sbjct: 192 LLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRM----------------- 234 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD-DA 353 + P Y + +A+DLL K+ V +P KR+ V D Sbjct: 235 -----DNPFYP--------------------RWLEKEAKDLLVKLFVREPEKRLGVRGDI 269 Query: 354 LQHPYINV--WYDPAEVEAPPPQIY 376 QHP W + E PP Sbjct: 270 RQHPLFREINWEELERKEIDPPFRP 294 >5J5T-A nrPDB Length = 370 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 89/412 (21%), Positives = 152/412 (36%), Gaps = 66/412 (16%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + ++ ++ IGSG G V A + AIK + + +E+++MK H Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK--LEPGEDFAVVQQEIIMMKDCKHP 61 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGIK 178 NI++ + + L ++ ME Q I L +++Y+ + L G+ Sbjct: 62 NIVAYFGSYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLY 115 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVI-- 235 +LHS G +HRD+K +NI++ + +K+ DFG++ + ++ T Y+ APEV Sbjct: 116 YLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAV 175 Query: 236 -LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 GY + D+W+VG E+ + M L P Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPP------------------------MFDLHPMR 211 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 ++ + + ++ + L +P KR + + L Sbjct: 212 ALFLMTKSNFQPPKLKDKMKW-------------SNSFHHFVKMALTKNPKKRPTAEKLL 258 Query: 355 QHPYINVWYD-------PAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN-SEEKTK 406 QHP++ +V P Y D+ + I+ N EEKT+ Sbjct: 259 QHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTR 318 Query: 407 N----GVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLE 454 + G VK P E LP S D SS T S+ D LE Sbjct: 319 SEITFGQVKFDPPLRKETEPHHE-LPDSDGFLD-SSEEIYYTARSNLDLQLE 368 >3HKO-A nrPDB Length = 345 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 88/375 (23%), Positives = 147/375 (39%), Gaps = 102/375 (27%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +N ++ G S + K+Y IG G+ G+V A + AIK +++ Q + Sbjct: 12 ENLYFQ---GGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQIN 68 Query: 105 AKRAYR---ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME 160 K R E+ LMK ++H NI L V+ + Q + LVMEL +L + + Sbjct: 69 PKDVERIKTEVRLMKKLHHPNIARLYEVYEDE------QYICLVMELCHGGHLLDKLNVF 122 Query: 161 LD------------------------------------------HERMSYLLYQMLCGIK 178 +D + +S ++ Q+ + Sbjct: 123 IDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALH 182 Query: 179 HLHSAGIIHRDLKPSNIVVKSD--CTLKILDFGLARTA-----GTSFMMTPYVVTRYYRA 231 +LH+ GI HRD+KP N + ++ +K++DFGL++ G + MT T Y+ A Sbjct: 183 YLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVA 242 Query: 232 PEVIL--GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 PEV+ Y D WS G ++ ++ + FPG + D ++V+ Sbjct: 243 PEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN------------ 290 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + P Y L + ARDLLS +L + +R Sbjct: 291 -----KKLCFENPNYNVL---------------------SPLARDLLSNLLNRNVDERFD 324 Query: 350 VDDALQHPYINVWYD 364 ALQHP+I+ + D Sbjct: 325 AMRALQHPWISQFSD 339 >3DAK-A nrPDB Length = 290 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 131/319 (41%), Gaps = 57/319 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Y+ + IGSGA +V AAY A VAIK+++ + QT +E+ M +H Sbjct: 9 RDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMSQCHH 67 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQ----------MELDHERMSYL 169 NI+S F + +++LVM+L+ + +I+ LD ++ + Sbjct: 68 PNIVSYYTSFVVK------DELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT------PY 223 L ++L G+++LH G IHRD+K NI++ D +++I DFG++ T +T + Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 V T + APEV+ GY DIWS G E+ + + + L Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL---MLTLQND 238 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 P +Q D E K R ++S L Sbjct: 239 PPSLETGVQ-----------------------------DKEMLKKYGKSFRKMISLCLQK 269 Query: 343 DPAKRISVDDALQHPYINV 361 DP KR + + L+H + Sbjct: 270 DPEKRPTAAELLRHKFFQK 288 >2A27-A nrPDB Length = 321 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 122/313 (38%), Gaps = 55/313 (17%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA----KRAYRELVLM 115 V Y + +GSG IV + A K + + + + RE+ ++ Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQ 172 + V H N+I+L +V+ E DV L++EL+ L + + L E + + Q Sbjct: 70 RQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDC----TLKILDFGLARTAGTSFMMTPYVVTRY 228 +L G+ +LH+ I H DLKP NI++ +K++DFGLA T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 + APE++ D+WS+G I ++ F G + + Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAV---------- 233 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 + D E + A+D + K+LV + KR+ Sbjct: 234 ----------------------------SYDFDEEFFSQTSELAKDFIRKLLVKETRKRL 265 Query: 349 SVDDALQHPYINV 361 ++ +AL+HP+I Sbjct: 266 TIQEALRHPWITP 278 >4QMW-A nrPDB Length = 310 Score = 234 bits (597), Expect = 6e-62, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 114/299 (38%), Gaps = 51/299 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ IG G+ G V D + VAIK + +E+ ++ + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSPYV 89 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLCGIKHLH 181 + L +++ME + L + LD +++ +L ++L G+ +LH Sbjct: 90 TKYYGSYLKDTKL------WIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLH 143 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILGMGY 240 S IHRD+K +N+++ +K+ DFG+A + +V T ++ APEVI Y Sbjct: 144 SEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 203 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 DIWS+G E+ R + + E Sbjct: 204 DSKADIWSLGITAIELARGEPP----------------------------------HSEL 229 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P PK P +L + ++ + L +P+ R + + L+H +I Sbjct: 230 HPMKVLFLIPKNNPPTL-------EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >1ZWS-A nrPDB Length = 288 Score = 234 bits (596), Expect = 8e-62, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 122/313 (38%), Gaps = 55/313 (17%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA----KRAYRELVLM 115 V Y + +GSG IV + A K + + + + RE+ ++ Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQ 172 + V H N+I+L +V+ E DV L++EL+ L + + L E + + Q Sbjct: 70 RQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQ 123 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDC----TLKILDFGLARTAGTSFMMTPYVVTRY 228 +L G+ +LH+ I H DLKP NI++ +K++DFGLA T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 + APE++ D+WS+G I ++ F G + + Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSV---------- 233 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 + D E + A+D + K+LV + KR+ Sbjct: 234 ----------------------------SYDFDEEFFSHTSELAKDFIRKLLVKETRKRL 265 Query: 349 SVDDALQHPYINV 361 ++ +AL+HP+I Sbjct: 266 TIQEALRHPWITP 278 >4YNZ-A nrPDB Length = 342 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 131/314 (41%), Gaps = 52/314 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ K +G G G+V V + VAIK ++R +++ + RE+ ++K + H ++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLYQMLCGIKHL 180 + L +V+ E + +YLV+E + L + + L + Q++ + Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 HS I HRDLKP N+++ ++I DFG+A ++ + +Y PEVI G Y Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 241 K-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 D+WS G I+ ++ + F + +++L V+ V Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDN-------------------LRQLLEKVKRGVF 226 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 + P + + LL M+ +D A+R++++ +H + Sbjct: 227 HMPHF-----------------------IPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY 263 Query: 360 NVWYDPAEVEAPPP 373 + E E P P Sbjct: 264 IGGKNEPEPEQPIP 277 >2XIK-A nrPDB Length = 294 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 111/302 (36%), Gaps = 51/302 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L IG G+ G V D VAIK + +E+ ++ + I Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSPYI 79 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLCGIKHLH 181 + L +++ME + L + L+ ++ +L ++L G+ +LH Sbjct: 80 TRYFGSYLKSTKL------WIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLH 133 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILGMGY 240 S IHRD+K +N+++ +K+ DFG+A + +V T ++ APEVI Y Sbjct: 134 SERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 193 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 DIWS+G E+ + + + +V+ + P ++ Sbjct: 194 DFKADIWSLGITAIELAKGEPP----NSDLHPMRVLFLIPKNSPPTLEGQH--------- 240 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 + ++ + L DP R + + L+H +I Sbjct: 241 ----------------------------SKPFKEFVEACLNKDPRFRPTAKELLKHKFIT 272 Query: 361 VW 362 + Sbjct: 273 RY 274 >3DB8-A nrPDB Length = 317 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 116/315 (36%), Gaps = 53/315 (16%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKCVN 119 +KRY + +G G D A K + + + H K E+ + K ++ Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCG 176 + +++ F VY+V+E+ +L ++ + + Y + Q + G Sbjct: 101 NPHVVGFHGFFEDDDF------VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQG 154 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRAPEVI 235 +++LH+ +IHRDLK N+ + D +KI DFGLA T Y APEV+ Sbjct: 155 VQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL 214 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 G+ VDIWS+GCI+ ++ K F + + ++ Sbjct: 215 CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI-------------------- 254 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 + + A L+ +ML DP R SV + L Sbjct: 255 ----------------------KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLT 292 Query: 356 HPYINVWYDPAEVEA 370 + Y P + Sbjct: 293 DEFFTSGYAPMRLPT 307 >5XVU-A nrPDB Length = 332 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 87/329 (26%), Positives = 156/329 (47%), Gaps = 23/329 (6%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 N+ K K ++Y + + + RY+ +K IG G V YD +R A Sbjct: 10 NIHKPK---EYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----I 61 Query: 98 PFQNQTHAKRAYRELVLMKCVNH-KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV 156 K+ RE+ +++ +N NII LL++ T L+ E ++ + Sbjct: 62 KVLKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPS----LIFEYINNIDFKT 117 Query: 157 IQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAG 215 + + + + Y +YQ+L + + HS GI+HRD+KP NI++ + ++++ +GLA Sbjct: 118 LYPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYH 177 Query: 216 TSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWN 273 V +RYY+ PE+++ + Y ++DIWS+GC++ M+ K F G D DQ Sbjct: 178 PGQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLV 237 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQA 332 K+ + LGT + L ++ Y ++ +P Y + + + + Sbjct: 238 KIAKVLGT------EDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEV 291 Query: 333 RDLLSKMLVIDPAKRISVDDALQHPYINV 361 DL+ KML+ D AKRI+ +A++HPY Sbjct: 292 IDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 >2HW6-A nrPDB Length = 307 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 79/331 (23%), Positives = 135/331 (40%), Gaps = 56/331 (16%) Query: 55 DSTFTVLKRYQNL-----KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 ST ++ +++++ + +G GA V A + A+K + + Q R + Sbjct: 1 GSTDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVF 58 Query: 110 RELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQV-IQMELDHER 165 RE+ + +KNI+ L+ F YLV E + L + Q + Sbjct: 59 REVETLYQCQGNKNILELIEFFEDDTRF------YLVFEKLQGGSILAHIQKQKHFNERE 112 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD---CTLKILDFGL--------ARTA 214 S ++ + + LH+ GI HRDLKP NI+ +S +KI DF L + T Sbjct: 113 ASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTP 172 Query: 215 GTSFMMTPYVVTRYYRAPEVI-----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYI 269 T+ +T + Y APEV+ Y + D+WS+G ++ M+ F G Sbjct: 173 ITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH--- 229 Query: 270 DQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA 329 G C ++ +N + + FP + + Sbjct: 230 ---------CGADCGWDRGEVCRVCQNKLFESIQEGKYEFPD-----------KDWAHIS 269 Query: 330 SQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 S+A+DL+SK+LV D +R+S LQHP++ Sbjct: 270 SEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >5X3F-B nrPDB Length = 393 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 132/352 (37%), Gaps = 61/352 (17%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR 110 E L ++ +K +G+G+ G V + A+K L + + Sbjct: 74 ETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLN 133 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMS 167 E +++ VN ++ L + + ++ ++Y+VME + + ++ Sbjct: 134 EKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHAR 187 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 + Q++ ++LHS +I+RDLKP N+++ +++ DFG A+ T Sbjct: 188 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTP 245 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y APE+IL GY + VD W++G ++ EM F I + K++ Sbjct: 246 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---------- 295 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 + FP F +S +DLL +L +D KR Sbjct: 296 -----------------GKVRFPSHF---------------SSDLKDLLRNLLQVDLTKR 323 Query: 348 I-----SVDDALQHPYI--NVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 V+D H + W + + P I + ++++E Sbjct: 324 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 375 >6FYV-A nrPDB Length = 337 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 82/329 (24%), Positives = 147/329 (44%), Gaps = 37/329 (11%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVL-DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH- 120 RY+ + +G GA G V D + +VA+K + + + + A E+ +++ +N Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHLNST 71 Query: 121 -KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMSYLLYQMLC 175 N + + + V +V EL+ + I+ + + + YQ+ Sbjct: 72 DPNSV--FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQ 129 Query: 176 GIKHLHSAGIIHRDLKPSNIV-VKSDCTLK------------------ILDFGLARTAGT 216 I LH + H DLKP NI+ VKSD +K ++DFG A Sbjct: 130 SINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDE 189 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 + V TR+YRAPEVIL +G+ + D+WS+GCI+ E +F D + ++ Sbjct: 190 HH--STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA-MM 246 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH---NKLKASQAR 333 E++ P P+ M + + + N+ + + + E + + + Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINVW 362 DL+ +ML DP +RI++D+ALQHP+ ++ Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFDLL 335 >6CMJ-A nrPDB Length = 321 Score = 231 bits (589), Expect = 6e-61, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 135/315 (42%), Gaps = 59/315 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP---------FQNQTHAKRAYRE 111 L +Y IG G+ G+V AY+ + A+K LS+ Q + ++ Y+E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMELDHERMSYL 169 + ++K ++H N++ L+ V +Y+V EL++ + L ++ + Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVMEVPTLKPLSEDQARFY 148 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRY 228 ++ GI++LH IIHRD+KPSN++V D +KI DFG++ G+ +++ V T Sbjct: 149 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPA 208 Query: 229 YRAPEVILGMG--YKENV-DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 + APE + + D+W++G + V + F +++ Sbjct: 209 FMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------MDERIM--------- 252 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + ++ K L FP A +DL+++ML +P Sbjct: 253 -----------CLHSKIKSQALEFPD-------------QPDIAEDLKDLITRMLDKNPE 288 Query: 346 KRISVDDALQHPYIN 360 RI V + HP++ Sbjct: 289 SRIVVPEIKLHPWVT 303 >4IAN-A nrPDB Length = 358 Score = 231 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 97/339 (28%), Positives = 158/339 (46%), Gaps = 32/339 (9%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVL-DRNVAIKKLSRPFQNQTHAK 106 +Y V +G+ + KRY G G V A D ++ VA+K + N+ K Sbjct: 19 YYRVNIGE---VLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQK 72 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM-----EL 161 +EL +K +N + + + Q + LV E + NL +V++ L Sbjct: 73 TGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGL 132 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL-KILDFGLARTAGTSFMM 220 + + Q+ +K L I+H D+KP NI+V T+ K+ DFG A + + Sbjct: 133 HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-I 191 Query: 221 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 TPY+V+R+YRAPE+I+G Y +D+WSVGC + E+ KILFPG+ ++ G Sbjct: 192 TPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKG 251 Query: 281 TPCPEFMKKLQPTVRNYVEN-------------RPKYAGLTFPKLFPDSLF-----PADS 322 + ++K +++ +N R K ++ D L Sbjct: 252 KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLP 311 Query: 323 EHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 E + K Q +DLL ++L++DPAKRIS++ ALQH +I Sbjct: 312 EDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >6HXF-B nrPDB Length = 302 Score = 231 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 121/307 (39%), Gaps = 57/307 (18%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ + +G GA G V A + A K + +++ + E+ ++ +H I Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHPYI 78 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD----HERMSYLLYQMLCGIKH 179 + LL + L ++++E I +ELD ++ + QML + Sbjct: 79 VKLLGAYYHDGKL------WIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 132 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-ARTAGTSFMMTPYVVTRYYRAPEVIL-- 236 LHS IIHRDLK N+++ + +++ DFG+ A+ T ++ T Y+ APEV++ Sbjct: 133 LHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCE 192 Query: 237 ---GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Y DIWS+G + EM + + + + K+ + Sbjct: 193 TMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDP------------- 239 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 P L P+ + + RD L L +P R S Sbjct: 240 --------------------PTLLTPSKW------SVEFRDFLKIALDKNPETRPSAAQL 273 Query: 354 LQHPYIN 360 L+HP+++ Sbjct: 274 LEHPFVS 280 >5N23-A nrPDB Length = 352 Score = 231 bits (588), Expect = 7e-61, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 132/352 (37%), Gaps = 60/352 (17%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR 110 E L +++ ++ +G+G+ G V + A+K L + + Sbjct: 32 ESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLN 91 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMS 167 E + + VN ++ L + + ++ ++Y+V+E + ++ Sbjct: 92 EKRIQQAVNFPFLVKL------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHAR 145 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 + Q++ ++LHS +I+RDLKP N+++ +K+ DFG A+ T T Sbjct: 146 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-LCGTP 204 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y APE+IL GY + VD W++G ++ EM F I + K++ Sbjct: 205 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---------- 254 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 + FP F +S +DLL +L +D KR Sbjct: 255 -----------------GKVRFPSHF---------------SSDLKDLLRNLLQVDLTKR 282 Query: 348 I-----SVDDALQHPYI--NVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 V+D H + W + + P I + ++++E Sbjct: 283 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 334 >2X4F-A nrPDB Length = 373 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 124/300 (41%), Gaps = 52/300 (17%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +G G G V + +A K + + + E+ +M ++H N+I L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKT--RGMKDKEEVKNEISVMNQLDHANLIQLY 152 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN-LCQVI---QMELDHERMSYLLYQMLCGIKHLHSA 183 + F E D+ LVME +D L I L + Q+ GI+H+H Sbjct: 153 DAF------ESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 184 GIIHRDLKPSNIV-VKSDC-TLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK 241 I+H DLKP NI+ V D +KI+DFGLAR + T + APEV+ Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVS 266 Query: 242 ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 D+WSVG I ++ F G + + N ++ R +E+ Sbjct: 267 FPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNIL----------------ACRWDLED- 309 Query: 302 PKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 E + + +A++ +SK+L+ + + RIS +AL+HP+++ Sbjct: 310 ---------------------EEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >3KN6-A nrPDB Length = 325 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 134/320 (41%), Gaps = 50/320 (15%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISL 126 KP+G G+ I ++ A+K +S+ + T +E+ +K H NI+ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ-----KEITALKLCEGHPNIVKL 71 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGIKHLHSA 183 VF Q +LVMEL++ L + I+ + SY++ +++ + H+H Sbjct: 72 HEVFHDQ------LHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 125 Query: 184 GIIHRDLKPSNIVV---KSDCTLKILDFGLAR-TAGTSFMMTPYVVTRYYRAPEVILGMG 239 G++HRDLKP N++ + +KI+DFG AR + + T +Y APE++ G Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNG 185 Query: 240 YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVE 299 Y E+ D+WS+G I+ M+ ++ F D +E + Sbjct: 186 YDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIM-------------------- 225 Query: 300 NRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 K F + E K + +A+DL+ +L +DP KR+ + + ++ Sbjct: 226 -----------KKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWL 274 Query: 360 NVWYDPAEVEAPPPQIYDKQ 379 + P I Sbjct: 275 QDGSQLSSNPLMTPDILGSS 294 >4WB7-A nrPDB Length = 405 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 133/352 (37%), Gaps = 61/352 (17%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYR 110 E L +++ +K +G+G+ G V + A+K L + + Sbjct: 86 ESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLN 145 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMS 167 E +++ VN ++ L + + ++ ++Y+VME + + ++ Sbjct: 146 EKRILQAVNFPFLVKL------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR 199 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 + Q++ ++LHS +I+RDLKP N+++ +++ DFG A+ T Sbjct: 200 FYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTP 257 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y APE+IL GY + VD W++G ++ EM F I + K++ Sbjct: 258 EYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS---------- 307 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 + FP F +S +DLL +L +D KR Sbjct: 308 -----------------GKVRFPSHF---------------SSDLKDLLRNLLQVDLTKR 335 Query: 348 I-----SVDDALQHPYI--NVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 V+D H + W + + P I + ++++E Sbjct: 336 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 387 >3NYO-A nrPDB Length = 576 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 81/347 (23%), Positives = 137/347 (39%), Gaps = 57/347 (16%) Query: 46 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA 105 N+F + + ++ + +G G G VCA + A KKL + + Sbjct: 168 NRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG 227 Query: 106 KR-AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQM 159 + A E +++ VN + ++SL + + L LV+ LM+ + + Q Sbjct: 228 EAMALNEKQILEKVNSRFVVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQA 281 Query: 160 ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 219 R + ++ CG++ LH I++RDLKP NI++ ++I D GLA Sbjct: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 279 + V T Y APEV+ Y + D W++GC++ EM+ + F R + +V E+L Sbjct: 342 IKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV-ERL 400 Query: 280 GTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 PE E+++ + QAR L S++ Sbjct: 401 VKEVPE-------------------------------------EYSERFSPQARSLCSQL 423 Query: 340 LVIDPAKRI-----SVDDALQHPYINVWYD--PAEVEAPPPQIYDKQ 379 L DPA+R+ S + +HP PP D Q Sbjct: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 >2OU7-A nrPDB Length = 335 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 115/307 (37%), Gaps = 53/307 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G DA A K + + ++ E+ + + + H++++ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 129 VFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGI 185 F E+ V++V+EL +L ++ + L Y L Q++ G ++LH + Sbjct: 109 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGYKENV 244 IHRDLK N+ + D +KI DFGLA + T Y APEV+ G+ V Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV 222 Query: 245 DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKY 304 D+WS+GCIM ++ K F + + ++ Sbjct: 223 DVWSIGCIMYTLLVGKPPFETSCLKETYLRI----------------------------- 253 Query: 305 AGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYD 364 + K A L+ KML DP R ++++ L + Y Sbjct: 254 -------------KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYI 300 Query: 365 PAEVEAP 371 PA + Sbjct: 301 PARLPIT 307 >4FZF-B nrPDB Length = 283 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 111/299 (37%), Gaps = 51/299 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + L+ IG G+ G V D + VAIK + +E+ ++ + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIED-IQQEITVLSQCDSSYV 68 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQMELDHERMSYLLYQMLCGIKHLH 181 + L +++ME + L + D +++ +L ++L G+ +LH Sbjct: 69 TKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLH 122 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVILGMGY 240 S IHRD+K +N+++ +K+ FG+A + +V T ++ APEVI Y Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAY 182 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 DIWS+G E+ + + + + +N Sbjct: 183 DSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI----------------------PKN 220 Query: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 P F K F ++ + L DP+ R + + L+H +I Sbjct: 221 NPPTLVGDFTKSF-------------------KEFIDACLNKDPSFRPTAKELLKHKFI 260 >2PVN-A nrPDB Length = 352 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 141/320 (44%), Gaps = 16/320 (5%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +++ E + Y+ ++ +G G V + + K + + + Sbjct: 35 PKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKK 90 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE 164 K +L NI+ LL++ Q + L+ E ++ +V+ L Sbjct: 91 KKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPS----LIFEYVNNTDFKVLYPTLTDY 146 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMTPY 223 + Y +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 147 DIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR 206 Query: 224 VVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWNKVIEQLGT 281 V +RY++ PE+++ Y ++D+WS+GC+ M+ K F G D DQ K+ + LGT Sbjct: 207 VASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGT 266 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 + +E P+ L L ++++ L + +A D L K+L Sbjct: 267 DGLNAYLN-----KYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLR 321 Query: 342 IDPAKRISVDDALQHPYINV 361 D +R++ +A+ HPY Sbjct: 322 YDHQERLTALEAMTHPYFQQ 341 >4J52-A nrPDB Length = 293 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 115/307 (37%), Gaps = 53/307 (17%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G DA A K + + ++ E+ + + + H++++ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 129 VFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGI 185 F E+ V++V+EL +L ++ + L Y L Q++ G ++LH + Sbjct: 82 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGYKENV 244 IHRDLK N+ + D +KI DFGLA + T Y APEV+ G+ V Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEV 195 Query: 245 DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKY 304 D+WS+GCIM ++ K F + + ++ Sbjct: 196 DVWSIGCIMYTLLVGKPPFETSCLKETYLRI----------------------------- 226 Query: 305 AGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYD 364 + K A L+ KML DP R ++++ L + Y Sbjct: 227 -------------KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYI 273 Query: 365 PAEVEAP 371 PA + Sbjct: 274 PARLPIT 280 >1VZO-A nrPDB Length = 355 Score = 227 bits (579), Expect = 7e-60, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 136/336 (40%), Gaps = 64/336 (19%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYD---AVLDRNVAIKKLSRP--FQNQTHAKRAYRELVLM 115 ++ ++ LK +G+GA G V + A+K L + Q + E ++ Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 116 KCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVI--QMELDHERMSYLLY 171 + + +++L F + L L+++ ++ L + + + + Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLH------LILDYINGGELFTHLSQRERFTEHEVQIYVG 166 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTRYY 229 +++ ++HLH GII+RD+K NI++ S+ + + DFGL++ + + T Y Sbjct: 167 EIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEY 226 Query: 230 RAPEVILG--MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 AP+++ G G+ + VD WS+G +M E++ F + ++ ++ P + Sbjct: 227 MAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP 286 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 +++ ++ A+DL+ ++L+ DP KR Sbjct: 287 QEM--------------------------------------SALAKDLIQRLLMKDPKKR 308 Query: 348 I-----SVDDALQHPYINV--WYDPAEVEAPPPQIY 376 + D+ +H + W D A + P P Sbjct: 309 LGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 344 >6ED6-A nrPDB Length = 415 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 75/345 (21%), Positives = 134/345 (38%), Gaps = 59/345 (17%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNH 120 + Y +K IG GA G V + A+K LS+ + + E +M N Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI-QMELDHERMSYLLYQMLCGIK 178 ++ L F + L Y+VME M +L ++ ++ + + +++ + Sbjct: 148 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM--TPYVVTRYYRAPEVIL 236 +HS G+IHRD+KP N+++ LK+ DFG + M+ V T Y +PEV+ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 237 GMG----YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 G Y D WSVG + EM+ F + ++K+++ + C Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC--------- 312 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---S 349 FP D+E + A++L+ L D R+ Sbjct: 313 -------------------------FPEDAE----ISKHAKNLICAFLT-DREVRLGRNG 342 Query: 350 VDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 V++ QHP+ W+ E P + + D ++ ++ Sbjct: 343 VEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIED 387 >5DBX-A nrPDB Length = 328 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 78/316 (24%), Positives = 129/316 (40%), Gaps = 57/316 (18%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y+ + IGSGA +V AA VAIK+++ + QT +E+ M +H N+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQAMSQCSHPNV 71 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM----------ELDHERMSYLLYQ 172 ++ F + +++LVM+L+ + +I+ L+ ++ +L + Sbjct: 72 VTYYTSFVVK------DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT------PYVVT 226 +L G+ +LH G IHRDLK NI++ D +++I DFG++ T +T +V T Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 + APEV+ GY D+WS G E+ + Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPP----------------- 228 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 MK L T++N D E K R LLS L DP+ Sbjct: 229 -MKVLMLTLQNDPPTL--------------ETGVEDKEMMKKYGKSFRKLLSLCLQKDPS 273 Query: 346 KRISVDDALQHPYINV 361 KR + + L+ + Sbjct: 274 KRPTAAELLKCKFFQK 289 >1U5R-A nrPDB Length = 348 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 70/341 (20%), Positives = 129/341 (37%), Gaps = 56/341 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAYRELVLMKCVNHKN 122 + +L+ IG G+ G V A D VAIKK+S Q+ + +E+ ++ + H N Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA---NLCQVIQMELDHERMSYLLYQMLCGIKH 179 I + + +LVME +L +V + L ++ + + L G+ + Sbjct: 116 TIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAY 169 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 LHS +IHRD+K NI++ +K+ DFG A +V T Y+ APEVIL Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMD 226 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y VD+WS+G E+ K + + + + Sbjct: 227 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN------------------ 268 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 + + + + R+ + L P R + + L+H Sbjct: 269 ----------------------ESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKH 306 Query: 357 PYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 ++ P + + D + + K+++++E Sbjct: 307 RFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 347 >2JD5-A nrPDB Length = 373 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 95/371 (25%), Positives = 166/371 (44%), Gaps = 46/371 (12%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK- 121 RY ++ +G G V A D V + +VA+K + ++ + + A E+ L++ VN Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 122 ----------NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM----ELDHERMS 167 +I+ LL+ F + V +V E++ NL +I+ + + Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVK 134 Query: 168 YLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVK------SDCTLKILDFGLARTAGTSFMM 220 + Q+L G+ ++H GIIH D+KP N++++ + +KI D G A + Sbjct: 135 QISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHY-- 192 Query: 221 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP---GRDYI---DQWNK 274 T + TR YR+PEV+LG + DIWS C++ E++ LF G Y D + Sbjct: 193 TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 275 VIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFP-DSLFPADSEHNKLKASQAR 333 +IE LG P ++ + R + +R ++ K +P + + + +K +A + Sbjct: 253 IIELLGE-LPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEIS 311 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKEL 393 D LS ML +DP KR + HP++ E+ P ++Y D I W E Sbjct: 312 DFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSD-----IPGWFE- 365 Query: 394 IYKEVMNSEEK 404 EV + + Sbjct: 366 ---EVRDHKRH 373 >1NY3-A nrPDB Length = 400 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 69/347 (19%), Positives = 140/347 (40%), Gaps = 60/347 (17%) Query: 60 VLKRYQNL-KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM-KC 117 ++ Y+ + +G G G V ++ A+K L +A RE+ L + Sbjct: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 111 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME----LDHERMSYLLYQ 172 +I+ +++V+ + + + +VME +D L IQ S ++ Sbjct: 112 SQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 + I++LHS I HRD+KP N++ S + LK+ DFG A+ + +T T YY Sbjct: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APEV+ Y ++ D+WS+G IM ++ F Sbjct: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-----------------------SN 266 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + ++ R + FP + + + + L+ +L +P +R++ Sbjct: 267 HGLAISPGMKTRIRMGQYEFPNPEWSEV-----------SEEVKMLIRNLLKTEPTQRMT 315 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 + + + HP+I + P ++ ++ + + E W+++ + Sbjct: 316 ITEFMNHPWIMQ-----STKVPQTPLHTSRVLKEDK--ERWEDVKEE 355 >5YV8-A nrPDB Length = 298 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 72/330 (21%), Positives = 135/330 (40%), Gaps = 74/330 (22%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP---------------------- 98 L +Y IG G+ G+V AY+ + A+K LS+ Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 99 --FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV 156 Q + ++ Y+E+ ++K ++H N++ L+ V +Y+V EL++ Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE----DHLYMVFELVNQGPVME 127 Query: 157 I--QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA 214 + L ++ + ++ GI++LH IIHRD+KPSN++V D +KI DFG++ Sbjct: 128 VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEF 187 Query: 215 -GTSFMMTPYVVTRYYRAPEVILGMG--YKENV-DIWSVGCIMGEMVRHKILFPGRDYID 270 G+ +++ V T + APE + + D+W++G + V + F Sbjct: 188 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------- 240 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 +++ + ++ K L FP A Sbjct: 241 MDERIM--------------------CLHSKIKSQALEFPD-------------QPDIAE 267 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYIN 360 +DL+++ML +P RI V + HP++ Sbjct: 268 DLKDLITRMLDKNPESRIVVPEIKLHPWVT 297 >3KA0-A nrPDB Length = 320 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 69/347 (19%), Positives = 140/347 (40%), Gaps = 60/347 (17%) Query: 60 VLKRYQNL-KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM-KC 117 ++ Y+ + +G G G V ++ A+K L +A RE+ L + Sbjct: 13 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 65 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME----LDHERMSYLLYQ 172 +I+ +++V+ + + + +VME +D L IQ S ++ Sbjct: 66 SQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 123 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 + I++LHS I HRD+KP N++ S + LK+ DFG A+ + +T T YY Sbjct: 124 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYY 183 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APEV+ Y ++ D+WS+G IM ++ F Sbjct: 184 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-----------------------SN 220 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + ++ R + FP + + + + L+ +L +P +R++ Sbjct: 221 HGLAISPGMKTRIRMGQYEFPNPEWSEV-----------SEEVKMLIRNLLKTEPTQRMT 269 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 + + + HP+I + P ++ ++ + + E W+++ + Sbjct: 270 ITEFMNHPWIMQ-----STKVPQTPLHTSRVLKEDK--ERWEDVKEE 309 >2GCD-A nrPDB Length = 309 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 70/341 (20%), Positives = 129/341 (37%), Gaps = 56/341 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS-RPFQNQTHAKRAYRELVLMKCVNHKN 122 + +L+ IG G+ G V A D VAIKK+S Q+ + +E+ ++ + H N Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA---NLCQVIQMELDHERMSYLLYQMLCGIKH 179 I + + +LVME +L +V + L ++ + + L G+ + Sbjct: 77 TIQYRGCYLRE------HTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAY 130 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 LHS +IHRD+K NI++ +K+ DFG A +V T Y+ APEVIL Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMD 187 Query: 237 GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Y VD+WS+G E+ K + + + + Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN------------------ 229 Query: 297 YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 + + + + R+ + L P R + + L+H Sbjct: 230 ----------------------ESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKH 267 Query: 357 PYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 ++ P + + D + + K+++++E Sbjct: 268 RFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 308 >2OZA-A nrPDB Length = 356 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 69/347 (19%), Positives = 140/347 (40%), Gaps = 60/347 (17%) Query: 60 VLKRYQNL-KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM-KC 117 ++ Y+ + +G G G V ++ A+K L +A RE+ L + Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 67 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME----LDHERMSYLLYQ 172 +I+ +++V+ + + + +VME +D L IQ S ++ Sbjct: 68 SQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 + I++LHS I HRD+KP N++ S + LK+ DFG A+ + +T T YY Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 185 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APEV+ Y ++ D+WS+G IM ++ F Sbjct: 186 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-----------------------SN 222 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + ++ R + FP + + + + L+ +L +P +R++ Sbjct: 223 HGLAISPGMKTRIRMGQYEFPNPEWSEV-----------SEEVKMLIRNLLKTEPTQRMT 271 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 + + + HP+I + P ++ ++ + + E W+++ + Sbjct: 272 ITEFMNHPWIMQ-----STKVPQTPLHTSRVLKEDK--ERWEDVKEE 311 >4EBW-A nrPDB Length = 304 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 116/285 (40%), Gaps = 26/285 (9%) Query: 42 SKVDNQFYSVEVGDSTFTV---LKRYQNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKL 95 +N ++ +G ST +R + + IG G G V + VAIK Sbjct: 15 PTTENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTC 74 Query: 96 SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----A 151 + ++ +E + M+ +H +I+ L+ V T V+++MEL Sbjct: 75 KNCTSDSV-REKFLQEALTMRQFDHPHIVKLIGVITE-------NPVWIIMELCTLGELR 126 Query: 152 NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA 211 + QV + LD + YQ+ + +L S +HRD+ N++V S+ +K+ DFGL+ Sbjct: 127 SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLS 186 Query: 212 RTAGTSFMMTPYVV--TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKI-LFPGRDY 268 R S + APE I + D+W G M E++ H + F G Sbjct: 187 RYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKN 246 Query: 269 IDQWNKVI--EQLGTP--CPEFMKKLQPTVRNY-VENRPKYAGLT 308 D ++ E+L P CP + L Y RP++ L Sbjct: 247 NDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 291 >4B8L-A nrPDB Length = 286 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 66/313 (21%), Positives = 125/313 (39%), Gaps = 54/313 (17%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYR 110 E+ FT+ + +P+G G G V A + +A+K L + + + + R Sbjct: 6 EMPKRKFTI-DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRR 64 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM--ELDHERMS 167 E+ + + H NI+ + N F +K +YL++E L + +Q D +R + Sbjct: 65 EIEIQSHLRHPNILRMYNYFHDRKR------IYLMLEFAPRGELYKELQKHGRFDEQRSA 118 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 + ++ + + H +IHRD+KP N+++ LKI DFG + A S T Sbjct: 119 TFMEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHA-PSLRRRTMCGTL 177 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 Y PE+I G + E VD+W G + E + F + + +++ Sbjct: 178 DYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV--------- 228 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 D + + ++DL+SK+L P +R Sbjct: 229 ---------------------------------DLKFPPFLSDGSKDLISKLLRYHPPQR 255 Query: 348 ISVDDALQHPYIN 360 + + ++HP++ Sbjct: 256 LPLKGVMEHPWVK 268 >6QAU-A nrPDB Length = 280 Score = 224 bits (571), Expect = 6e-59, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 123/277 (44%), Gaps = 24/277 (8%) Query: 54 GDSTFTVLKRYQNLKP--IGSGAQGIVCAAYDA-VLDRNVAIKKLSRPFQNQTHAKRAYR 110 G + V+ ++ K +G GA +V D VAIK +++ +++ + Sbjct: 1 GGGSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGK 59 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMS 167 E+ ++K + H+NI++L +V E V+LVME + +L +Q + L + + Sbjct: 60 EIKILKELQHENIVALYDV------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIR 113 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---------SDCTLKILDFGLARTAGTSF 218 L+Q+ ++ LHS GIIHRDLKP NI++ S +KI DFG AR ++ Sbjct: 114 VFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM 173 Query: 219 MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID--QWNKVI 276 M + Y APEVI+ Y D+WS+G ++ + + K F D + + Sbjct: 174 MAADLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKN 233 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLF 313 L P + + R + + F F Sbjct: 234 RSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFF 270 >4AF3-A nrPDB Length = 292 Score = 224 bits (571), Expect = 6e-59, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 130/309 (42%), Gaps = 53/309 (17%) Query: 56 STFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVL 114 + + ++ +P+G G G V A + VA+K L + + + + RE+ + Sbjct: 17 TRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEI 76 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME--LDHERMSYLLY 171 ++H NI+ L N F ++ +YL++E L + +Q D +R + ++ Sbjct: 77 QAHLHHPNILRLYNYFYDRRR------IYLILEYAPRGELYKELQKSCTFDEQRTATIME 130 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 ++ + + H +IHRD+KP N+++ LKI DFG + A S T Y Sbjct: 131 ELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHA-PSLRRKTMCGTLDYLP 189 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 PE+I G + E VD+W +G + E++ F + + + ++++ Sbjct: 190 PEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV------------- 236 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 L FP P A+DL+SK+L +P++R+ + Sbjct: 237 --------------DLKFPASVPTG---------------AQDLISKLLRHNPSERLPLA 267 Query: 352 DALQHPYIN 360 HP++ Sbjct: 268 QVSAHPWVR 276 >6E9W-A nrPDB Length = 443 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 74/350 (21%), Positives = 131/350 (37%), Gaps = 59/350 (16%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY-RELVLMKCVNH 120 + Y+ +K IG GA G V + A+K LS+ + + E +M N Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI-QMELDHERMSYLLYQMLCGIK 178 ++ L F + L Y+VME M +L ++ ++ + + +++ + Sbjct: 162 PWVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALD 215 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM--TPYVVTRYYRAPEVIL 236 +HS G IHRD+KP N+++ LK+ DFG M+ V T Y +PEV+ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 237 GMG----YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 G Y D WSVG + EM+ F + ++K++ Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN--------------- 320 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---S 349 LTFP + + +A++L+ L D R+ Sbjct: 321 ----------HKNSLTFPD-------------DNDISKEAKNLICAFLT-DREVRLGRNG 356 Query: 350 VDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397 V++ +H + W + P + D D ++ +E +E Sbjct: 357 VEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEE 406 >4CRL-A nrPDB Length = 406 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 93/350 (26%), Positives = 159/350 (45%), Gaps = 44/350 (12%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLK-PIGSGAQGIVCAAYDAVLDRN--VAIKKLSRP 98 + + V++ V ++ +G G G V A + A+K++ Sbjct: 1 DDKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI--- 57 Query: 99 FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ 158 + + A RE+ L++ + H N+ISL VF + V+L+ + + +L +I+ Sbjct: 58 -EGTGISMSACREIALLRELKHPNVISLQKVFLSHAD----RKVWLLFDYAEHDLWHIIK 112 Query: 159 M-----------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----SDCTL 203 +L + LLYQ+L GI +LH+ ++HRDLKP+NI+V + Sbjct: 113 FHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV 172 Query: 204 KILDFGLARTAGTSFM----MTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVR 258 KI D G AR + + P VVT +YRAPE++LG Y + +DIW++GCI E++ Sbjct: 173 KIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT 232 Query: 259 HKILFPGRD---------YIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTF 309 + +F R + DQ +++ +G P + + ++ E+ Sbjct: 233 SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWED----IKKMPEHSTLMKDFRR 288 Query: 310 PKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 SL +H S+A LL K+L +DP KRI+ + A+Q PY Sbjct: 289 NTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >4RA4-A nrPDB Length = 355 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 123/346 (35%), Gaps = 61/346 (17%) Query: 44 VDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103 ++ + L + L +G G+ G V A + AIK L + Q Sbjct: 2 SPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQD 61 Query: 104 HAKRAYR-ELVLMKCVNHK-NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM- 159 E ++ ++ + L + F +Y VME ++ +L IQ Sbjct: 62 DDVECTMVEKRVLALLDKPPFLTQLHSCFQT------VDRLYFVMEYVNGGDLMYHIQQV 115 Query: 160 -ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTS 217 + + + ++ G+ LH GII+RDLK N+++ S+ +KI DFG+ + Sbjct: 116 GKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG 175 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 + T Y APE+I Y ++VD W+ G ++ EM+ + F G D + + ++E Sbjct: 176 VTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 Query: 278 QLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 + + K + +A + Sbjct: 236 H------------------------------------------NVSYPKSLSKEAVSICK 253 Query: 338 KMLVIDPAKRISV-----DDALQHPYIN--VWYDPAEVEAPPPQIY 376 ++ PAKR+ D +H + W E PP Sbjct: 254 GLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 299 >3RAW-A nrPDB Length = 381 Score = 224 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 74/373 (19%), Positives = 147/373 (39%), Gaps = 39/373 (10%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFT------VLKRYQNLKPIGSGAQGIVCAA 81 VD+ ++ +S + + + + +RY+ + +G G G V Sbjct: 11 VDLGTENLYFQSMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVEC 70 Query: 82 YDAVLDR-NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQ 140 D + VA+K + + + + A E+ ++K + K+ + Sbjct: 71 LDHARGKSQVALKIIRNVGK---YREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHG 127 Query: 141 DVYLVMELMDANLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 + + EL+ N + ++ + ++ YQ+ ++ LH + H DLKP NI+ Sbjct: 128 HMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL 187 Query: 197 VKS-------------------DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 + + ++++ DFG A T V TR+YR PEVIL Sbjct: 188 FVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH--TTIVATRHYRPPEVILE 245 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 +G+ + D+WS+GCI+ E R LF + + ++E++ P P M + + Sbjct: 246 LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL-VMMEKILGPIPSHMIHRTRKQKYF 304 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQ---ARDLLSKMLVIDPAKRISVDDAL 354 + + + + + + + DL+ +ML DPA+RI++ +AL Sbjct: 305 YKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEAL 364 Query: 355 QHPYINVWYDPAE 367 HP+ Sbjct: 365 LHPFFAGLTPEER 377 >6CKI-A nrPDB Length = 316 Score = 224 bits (570), Expect = 9e-59, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 135/344 (39%), Gaps = 59/344 (17%) Query: 55 DSTFTVLKRYQNL-----KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 ST + R++++ +G GA V + + + A+K + + Q R + Sbjct: 1 GSTDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEK--QPGHIRSRVF 58 Query: 110 RELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN--LCQVIQME-LDHER 165 RE+ ++ H+N V + EE YLV E M L + + + Sbjct: 59 REVEMLYQCQGHRN------VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELE 112 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL---KILDFGL---------ART 213 S ++ + + LH+ GI HRDLKP NI+ + + KI DFGL Sbjct: 113 ASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSP 172 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGMG-----YKENVDIWSVGCIMGEMVRHKILFPGRDY 268 T ++TP + Y APEV+ Y + D+WS+G I+ ++ F GR Sbjct: 173 ISTPELLTP-CGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGR-- 229 Query: 269 IDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLK 328 G+ C + P +N + + FP + Sbjct: 230 ----------CGSDCGWDRGEACPACQNMLFESIQEGKYEFPD-----------KDWAHI 268 Query: 329 ASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPP 372 + A+DL+SK+LV D +R+S LQHP++ P P Sbjct: 269 SCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ-GCAPENTLPTP 311 >4MD7-E nrPDB Length = 391 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 72/319 (22%), Positives = 143/319 (44%), Gaps = 18/319 (5%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +++ E + YQ ++ +G G V A + + + Sbjct: 20 PREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVK 74 Query: 105 AKRAYRELVLMKCVNH-KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH 163 K+ RE+ +++ + NII+L ++ + LV E ++ + + L Sbjct: 75 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQLYQTLTD 130 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMTP 222 + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 131 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 190 Query: 223 YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWNKVIEQLG 280 V +RY++ PE+++ Y ++D+WS+GC++ M+ K F G D DQ ++ + LG Sbjct: 191 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 250 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 T + +E P++ + SE+ L + +A D L K+L Sbjct: 251 TE-----DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 305 Query: 341 VIDPAKRISVDDALQHPYI 359 D R++ +A++HPY Sbjct: 306 RYDHQSRLTAREAMEHPYF 324 >6HMD-A nrPDB Length = 365 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 74/319 (23%), Positives = 151/319 (47%), Gaps = 18/319 (5%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +++ E ++ YQ ++ +G G V A + + ++ Sbjct: 36 SREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVK 90 Query: 105 AKRAYRELVLMKCVNHK-NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH 163 K+ RE+ +++ + NII L++ + LV E ++ + + L Sbjct: 91 KKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPA----LVFEYINNTDFKQLYQILTD 146 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTP 222 + + +Y++L + + HS GI+HRD+KP N+++ L+++D+GLA + Sbjct: 147 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 206 Query: 223 YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLG 280 V +RY++ PE+++ Y ++D+WS+GC++ M+ R + F G+D DQ ++ + LG Sbjct: 207 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 266 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 T E L+ + +++ P + + SE+ L + +A DLL K+L Sbjct: 267 T--EELYGYLK---KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLL 321 Query: 341 VIDPAKRISVDDALQHPYI 359 D +R++ +A++HPY Sbjct: 322 RYDHQQRLTAKEAMEHPYF 340 >3LM0-A nrPDB Length = 327 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 73/373 (19%), Positives = 136/373 (36%), Gaps = 74/373 (19%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87 VD+ ++ ++ N FY + K +G G +V Sbjct: 11 VDLGTENLYFQSMENF--NNFYILTS--------------KELGRGKFAVVRQCISKSTG 54 Query: 88 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVM 146 + A K L + + Q E+ +++ +I+L V+ E ++ L++ Sbjct: 55 QEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVY------ENTSEIILIL 108 Query: 147 ELMDAN-LCQVIQMEL----DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-- 199 E + + EL + L+ Q+L G+ +LH I+H DLKP NI++ S Sbjct: 109 EYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIY 168 Query: 200 -DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR 258 +KI+DFG++R G + + + T Y APE++ D+W++G I ++ Sbjct: 169 PLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLT 228 Query: 259 HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLF 318 H F G D + + + + Y+ TF + Sbjct: 229 HTSPFVGEDNQETYLNISQV----------------------NVDYSEETFSSV------ 260 Query: 319 PADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVW-----YDPAEVEAPPP 373 + A D + +LV +P KR + + L H ++ W + P E + Sbjct: 261 ----------SQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQ 310 Query: 374 QIYDKQLDEREHT 386 + T Sbjct: 311 TQDHSVRSSEDKT 323 >4APC-A nrPDB Length = 350 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 128/314 (40%), Gaps = 55/314 (17%) Query: 50 SVEVGDST--FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 V++G F +++Y L+ IG G+ G R IK+++ + + Sbjct: 10 GVDLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREE 69 Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LD 162 + RE+ ++ + H NI+ F EE +Y+VM+ + +L + I + Sbjct: 70 SRREVAVLANMKHPNIVQYRESF------EENGSLYIVMDYCEGGDLFKRINAQKGVLFQ 123 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 222 +++ Q+ +KH+H I+HRD+K NI + D T+++ DFG+AR ++ + Sbjct: 124 EDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELAR 183 Query: 223 YV-VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 T YY +PE+ Y DIW++GC++ E+ K F + K+I Sbjct: 184 ACIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKII----- 238 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 FP S H + R L+S++ Sbjct: 239 ---------------------------------SGSFPPVSLHY---SYDLRSLVSQLFK 262 Query: 342 IDPAKRISVDDALQ 355 +P R SV+ L+ Sbjct: 263 RNPRDRPSVNSILE 276 >3FXW-A nrPDB Length = 336 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 75/355 (21%), Positives = 140/355 (39%), Gaps = 71/355 (20%) Query: 57 TFTVLKRYQNLK-PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 + V YQ K +G G G V + + A+K L + +A +E+ Sbjct: 23 KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-------YDSPKARQEVD-- 73 Query: 116 KCVNH------KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME----LDHE 164 +H +I+ +L+V+ + + + ++ME M+ L IQ Sbjct: 74 ---HHWQASGGPHIVCILDVY--ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTER 128 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMT 221 + ++ + I+ LHS I HRD+KP N++ S D LK+ DFG A+ + + T Sbjct: 129 EAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQT 188 Query: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 P T YY APEV+ Y ++ D+WS+G IM ++ F Sbjct: 189 P-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFY----------------- 230 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 + ++ R + FP + + A+ L+ +L Sbjct: 231 ------SNTGQAISPGMKRRIRLGQYGFPNPEWSEV-----------SEDAKQLIRLLLK 273 Query: 342 IDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 DP +R+++ + HP+IN + P ++ ++ + + + W E+ + Sbjct: 274 TDPTERLTITQFMNHPWINQ-----SMVVPQTPLHTARVLQEDK--DHWDEVKEE 321 >3A8W-A nrPDB Length = 345 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 123/333 (36%), Gaps = 53/333 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKC-V 118 L+ + L+ IG G+ V DR A+K + + N + E + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLC 175 NH ++ L + F + L + V+E ++ Q +L E + ++ Sbjct: 68 NHPFLVGLHSCFQTESRL------FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL 121 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPEV 234 + +LH GII+RDLK N+++ S+ +K+ D+G+ + + + T Y APE+ Sbjct: 122 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 181 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + G Y +VD W++G +M EM+ + F ++ P L + Sbjct: 182 LRGEDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQNTEDYLFQVI 231 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV---- 350 P+ + +A +L L DP +R+ Sbjct: 232 LEKQIRIPR-----------------------SLSVKAASVLKSFLNKDPKERLGCHPQT 268 Query: 351 --DDALQHPYIN--VWYDPAEVEAPPPQIYDKQ 379 D HP+ W + + PP + Sbjct: 269 GFADIQGHPFFRNVDWDMMEQKQVVPPFKPNIS 301 >5LOH-A nrPDB Length = 341 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 125/334 (37%), Gaps = 60/334 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 ++ + +KPI GA G V + A+K + + N+ + E + Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ---VIQMELDHERMSYLLYQMLCG 176 I+ L +L+ +VYLVME + + I D E + ++ Sbjct: 93 SPFIVHLYY------SLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALA 146 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-------TAGTSFMMTPYVVTRYY 229 + +LH GIIHRDLKP N+++ ++ +K+ DFGL++ + T Y Sbjct: 147 LDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDY 206 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APE++LG + VD W++G + E + F + ++++ P PE +K Sbjct: 207 LAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKR-DIPWPEGEEK 265 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 L ++ VE +L ID KR Sbjct: 266 LSDNAQSAVEI--------------------------------------LLTIDDTKRAG 287 Query: 350 VDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLD 381 + + +HP + W + P D + D Sbjct: 288 MKELKRHPLFSDVDWENLQHQTMPFIPQPDDETD 321 >4WNO-A nrPDB Length = 287 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 128/326 (39%), Gaps = 61/326 (18%) Query: 50 SVEVGDSTFTVLKRYQNLKP--IGSGAQGIVCAAYDAVLDR-NVAIKKLSRPFQNQTHAK 106 S+E G + +++ + IG GA +V VA+K +++ ++ Sbjct: 4 SMEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQT- 62 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--MELDH 163 +E+ ++K + H+NI++L + E VYLVME + +L + L Sbjct: 63 LLGKEIKILKELKHENIVALYDF------QEMANSVYLVMEYCNGGDLADYLHAMRTLSE 116 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---------DCTLKILDFGLARTA 214 + + L Q+ ++ LHS GIIHRDLKP NI++ + +KI DFG AR Sbjct: 117 DTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL 176 Query: 215 GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNK 274 ++ M + Y APEVI+ Y D+WS+G I+ + + K F Sbjct: 177 QSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASS------- 229 Query: 275 VIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD 334 P+ ++ + V P+ +L L Sbjct: 230 ---------PQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQR--------------- 265 Query: 335 LLSKMLVIDPAKRISVDDALQHPYIN 360 + R+ D+ HP+++ Sbjct: 266 --------NHKDRMDFDEFFHHPFLD 283 >4U41-A nrPDB Length = 332 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 71/354 (20%), Positives = 129/354 (36%), Gaps = 60/354 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKN 122 ++ ++ +G+G G V + AIK + + K E+ ++K +H+N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRN 82 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----LDHERMSYLLYQMLCGI 177 I + F + ++LVME ++ +++ L + ++Y+ ++L G+ Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEVIL 236 HLH +IHRD+K N+++ + +K++DFG++ + ++ T Y+ APEVI Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 Y D+WS G EM + + P P K Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR---NPPPRLKSKKW 259 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 + LV + +R S + Sbjct: 260 SKKFFSF-------------------------------------IEGCLVKNYMQRPSTE 282 Query: 352 DALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKT 405 L+HP+I P E + Q+ D R+ E K+ E SEE Sbjct: 283 QLLKHPFIRDQ--PNERQVRI-QLKDHIDRTRKKRGE--KDETEYEYSGSEEGN 331 >5KKR-C nrPDB Length = 395 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 139/328 (42%), Gaps = 22/328 (6%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 +VG+ ++ + +G+G G+V +A K + + + Sbjct: 59 KQKVGELK---DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQII 114 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERM 166 REL ++ N I+ F ++ + ME MD L QV++ + + + Sbjct: 115 RELQVLHECNSPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQIL 168 Query: 167 SYLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 + ++ G+ +L I+HRD+KPSNI+V S +K+ DFG++ S +V Sbjct: 169 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVG 227 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTP 282 TR Y +PE + G Y DIWS+G + EM + P D + + +E Sbjct: 228 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 287 Query: 283 CPEFMKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 P + + +Y +++RP A + P + + + + +D ++K L+ Sbjct: 288 TPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNE--PPPKLPSAVFSLEFQDFVNKCLI 345 Query: 342 IDPAKRISVDDALQHPYINVWYDPAEVE 369 +PA+R + + H +I D EV+ Sbjct: 346 KNPAERADLKQLMVHAFIKR-SDAEEVD 372 >3ORZ-A nrPDB Length = 316 Score = 221 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 129/327 (39%), Gaps = 61/327 (18%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVNH 120 + ++ K +G G+ V A + R AIK L R + RE +M ++H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM--ELDHERMSYLLYQMLCGI 177 + L F + +Y + + L + I+ D + +++ + Sbjct: 97 PFFVKLYFCFQDD------EKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSAL 150 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM---TPYVVTRYYRAPEV 234 ++LH GIIHRDLKP NI++ D ++I DFG A+ +V T Y +PE+ Sbjct: 151 EYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPEL 210 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + ++ D+W++GCI+ ++V F + + K+I+ Sbjct: 211 LTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIK----------------- 253 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD-- 352 FP+ FP +ARDL+ K+LV+D KR+ ++ Sbjct: 254 --------------LEYDFPEKFFP-----------KARDLVEKLLVLDATKRLGCEEME 288 Query: 353 ----ALQHPYINVWYDPAEVEAPPPQI 375 HP+ + PP++ Sbjct: 289 GYGPLKAHPFFESVTWENLHQQTPPKL 315 >2WTK-C nrPDB Length = 305 Score = 221 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 82/344 (23%), Positives = 132/344 (38%), Gaps = 57/344 (16%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA--YRELVLMKC 117 ++ +Y +G G+ G V D+ A+K L + + A +E+ L++ Sbjct: 3 LIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRR 62 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMEL----MDANLCQVIQMELDHERMSYLLYQM 173 + HKN+I L++V EE Q +Y+VME M L V + + Q+ Sbjct: 63 LRHKNVIQLVDVLYN----EEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQL 118 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT---SFMMTPYVVTRYYR 230 + G+++LHS GI+H+D+KP N+++ + TLKI G+A + ++ Sbjct: 119 IDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQ 178 Query: 231 APEVILGMG--YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 PE+ G+ VDIWS G + + F G D K+ E +G Sbjct: 179 PPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIGK------- 227 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 DLL ML +PAKR Sbjct: 228 -------------------------------GSYAIPGDCGPPLSDLLKGMLEYEPAKRF 256 Query: 349 SVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 S+ QH + + PAE P P D + R T+ + E Sbjct: 257 SIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLE 300 >2X7G-A nrPDB Length = 389 Score = 221 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 99/382 (25%), Positives = 148/382 (38%), Gaps = 82/382 (21%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 ++ V++GD RY ++ +G G V +D R VA+K + Q + + Sbjct: 20 YHPVKIGD---LFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTET 73 Query: 108 AYRELVLMKCVN-----HKN---IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-- 157 A E+ L+KCV N ++ L++ F V +V E++ +L + I Sbjct: 74 ALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISG--MNGIHVCMVFEVLGHHLLKWIIK 131 Query: 158 --QMELDHERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVV----------------- 197 L + ++ Q+L G+ +LHS IIH D+KP NI++ Sbjct: 132 SNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEW 191 Query: 198 ------------------------------KSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 +KI D G A F T + TR Sbjct: 192 QKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHF--TEDIQTR 249 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP---GRDYI---DQWNKVIEQLGT 281 YR+ EV++G GY DIWS C+ E+ LF G DY D +IE LG+ Sbjct: 250 QYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGS 309 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQA---RDLLSK 338 P R + R + +T KL P SLF E A D L Sbjct: 310 -IPRHFALSGKYSREFFNRRGELRHIT--KLKPWSLFDVLVEKYGWPHEDAAQFTDFLIP 366 Query: 339 MLVIDPAKRISVDDALQHPYIN 360 ML + P KR S + L+HP++N Sbjct: 367 MLEMVPEKRASAGECLRHPWLN 388 >4TNB-A nrPDB Length = 590 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 64/329 (19%), Positives = 126/329 (38%), Gaps = 57/329 (17%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVNHKN 122 ++ + +G G G VCA + A K+L + + + A E +++ VN + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-----QMELDHERMSYLLYQMLCGI 177 +++L + + L LV+ +M+ + + ER + ++LCG+ Sbjct: 246 VVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 + LH ++RDLKP NI++ ++I D GLA ++ V T Y APEV+ Sbjct: 300 EDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y + D W +GC++ EM+ + F GR + +V + Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR------------------- 400 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDD 352 + + ++ + +A+ + +L D +R+ + Sbjct: 401 -------------------VLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAE 441 Query: 353 ALQHPYINVWYD--PAEVEAPPPQIYDKQ 379 +HP+ PP + D + Sbjct: 442 VKRHPFFRNMNFKRLEAGMLDPPFVPDPR 470 >3EQC-A nrPDB Length = 360 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 138/328 (42%), Gaps = 22/328 (6%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 +VG+ ++ + +G+G G+V +A K + + + Sbjct: 24 KQKVGELK---DDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQII 79 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERM 166 REL ++ N I+ F ++ + ME MD L QV++ + + + Sbjct: 80 RELQVLHECNSPYIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQIL 133 Query: 167 SYLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 + ++ G+ +L I+HRD+KPSNI+V S +K+ DFG++ S +V Sbjct: 134 GKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVG 192 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID---QWNKVIEQLGTP 282 TR Y +PE + G Y DIWS+G + EM + P D + + +E Sbjct: 193 TRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAE 252 Query: 283 CPEFMKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 P + + + +++RP A + P + + + + +D ++K L+ Sbjct: 253 TPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNE--PPPKLPSGVFSLEFQDFVNKCLI 310 Query: 342 IDPAKRISVDDALQHPYINVWYDPAEVE 369 +PA+R + + H +I D EV+ Sbjct: 311 KNPAERADLKQLMVHAFIKR-SDAEEVD 337 >6BDL-A nrPDB Length = 347 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 128/344 (37%), Gaps = 58/344 (16%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDA-VLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCV 118 L + + +G G G V + A+K L + + + E +M+ Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 92 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVME-LMDANLCQVIQME--LDHERMSYLLYQMLC 175 + I+ L F K L Y++ME + L +++ + + ++ Sbjct: 93 HSDFIVRLYRTFKDSKYL------YMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE 146 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +LHS GII+RDLKP N+++ K++DFG A+ G + T Y APE+I Sbjct: 147 AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 236 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 295 L G+ + D WS+G +M E++ F G D + +N ++ + Sbjct: 207 LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM-------------- 252 Query: 296 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SV 350 + FPK A A +L+ K+ +P++R+ V Sbjct: 253 -----------IEFPK---------------KIAKNAANLIKKLCRDNPSERLGNLKNGV 286 Query: 351 DDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 D +H + W + PP I + + E Sbjct: 287 KDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 330 >6EII-A nrPDB Length = 352 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 144/319 (45%), Gaps = 18/319 (5%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 ++++ E + YQ ++ +G G V A + + V Sbjct: 43 PSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKV-----VVKILKPVK 97 Query: 105 AKRAYRELVLMKCVNH-KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH 163 K+ RE+ +++ + NII+L ++ + LV E ++ + + L Sbjct: 98 KKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQLYQTLTD 153 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTSFMMTP 222 + + +Y++L + + HS GI+HRD+KP N+++ + L+++D+GLA Sbjct: 154 YDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNV 213 Query: 223 YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKIL-FPGRDYIDQWNKVIEQLG 280 V +RY++ PE+++ Y ++D+WS+GC++ M+ K F G D DQ ++ + LG Sbjct: 214 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG 273 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 T + +E P++ + SE+ L + +A D L K+L Sbjct: 274 TE-----DLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL 328 Query: 341 VIDPAKRISVDDALQHPYI 359 D R++ +A++HPY Sbjct: 329 RYDHQSRLTAREAMEHPYF 347 >5DYK-A nrPDB Length = 853 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 87/381 (22%), Positives = 140/381 (36%), Gaps = 65/381 (17%) Query: 21 CQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCA 80 C DK V + I + +++ D+ + + + IG G G V Sbjct: 505 CWFVDKSVFLQIIQGPMLAHLEE------RIKMQDTKVE-MDELETERIIGRGTFGTVKL 557 Query: 81 AYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEF 139 + A+K + R N E + +H II L+ F K Sbjct: 558 VHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYF--- 614 Query: 140 QDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 Y + EL+ L I+ L + + L ++ I++LH I++RDLKP NI+ Sbjct: 615 ---YFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENIL 671 Query: 197 VKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM 256 + +K++DFG A+ V T +Y APEVILG GY VDIW++G + E Sbjct: 672 LDKQGYVKLIDFGCAKKV--QGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEF 729 Query: 257 VRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDS 316 + + F G D DQ + + T LTFP D+ Sbjct: 730 ICGPLPF-GNDEEDQLE-IFRDILT-----------------------GQLTFPDYVTDT 764 Query: 317 LFPADSEHNKLKASQARDLLSKMLVIDPAKRISV-----DDALQHPYIN--VWYDPAEVE 369 + +L+ ++L P RI D HP+ + W A Sbjct: 765 --------------DSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRL 810 Query: 370 APPPQIYDKQLDEREHTIEEW 390 PP + + + I++ Sbjct: 811 LDPPLVSKSETYAEDIDIKQI 831 >2XYN-A nrPDB Length = 292 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 118/292 (40%), Gaps = 35/292 (11%) Query: 50 SVEVGDST--FTVLKRYQNLK-------PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ 100 V++G F + +++ + +G G G V VA+K L + Sbjct: 11 GVDLGTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK---E 67 Query: 101 NQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM 159 + + +E +MK + H N++ LL V T + Y+V E M NL ++ Sbjct: 68 DTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPF------YIVTEYMPYGNLLDYLRE 121 Query: 160 ----ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG 215 E+ + Y+ Q+ +++L IHRDL N +V + +K+ DFGL+R Sbjct: 122 CNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM- 180 Query: 216 TSFMMTPYVV---TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQ 271 T T + + APE + + D+W+ G ++ E+ +PG D Sbjct: 181 TGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV 240 Query: 272 WNKVIEQLGTP----CPEFMKKLQPTVRNY-VENRPKYAGL--TFPKLFPDS 316 ++ + + CP + +L + +RP +A F +F DS Sbjct: 241 YDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 292 >4XEY-B nrPDB Length = 408 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 123/336 (36%), Gaps = 26/336 (7%) Query: 6 LYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQ 65 LY SE + D HY K + D Sbjct: 69 LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT 128 Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +G G G V VA+K L ++ + +E +MK + H N++ Sbjct: 129 MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQ 185 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHL 180 LL V T + Y++ E M NL ++ E++ + Y+ Q+ +++L Sbjct: 186 LLGVCTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 239 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYRAPEVILG 237 IHRDL N +V + +K+ DFGL+R T T + + APE + Sbjct: 240 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAY 298 Query: 238 MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMKKLQP 292 + D+W+ G ++ E+ +PG D + + + CPE + +L Sbjct: 299 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 358 Query: 293 TVRNY-VENRPKYAGL--TFPKLFPDSLFPADSEHN 325 + +RP +A + F +F +S + E Sbjct: 359 ACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKE 394 >5UNP-A nrPDB Length = 369 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 84/356 (23%), Positives = 156/356 (43%), Gaps = 52/356 (14%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYD-AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 + +RY+ + +G G G V D VA+K + + + + A E+ +++ + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNV---EKYKEAARLEINVLEKI 88 Query: 119 N-----HKNI-ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ----MELDHERMSY 168 N +KN+ + + + F + + EL+ + ++ + ++ + Sbjct: 89 NEKDPDNKNLCVQMFDWFDYHG------HMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIV-VKSDCT------------------LKILDFG 209 + +Q+ +K LH + H DLKP NI+ V SD ++++DFG Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 210 LARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYI 269 A + V TR+YRAPEVIL +G+ + D+WS+GCI+ E LF D Sbjct: 203 SATFDHEHH--STIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNR 260 Query: 270 DQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA 329 + ++E++ P P M + + + R + T + + +A Sbjct: 261 EHLA-MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEA 319 Query: 330 SQ---ARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPP-QIYDKQLD 381 + DL+ ML +PAKR+++ +ALQHP+ A + A PP +++D D Sbjct: 320 EEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF------ARLRAEPPNKLWDSSRD 369 >2FO0-A nrPDB Length = 495 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 70/336 (20%), Positives = 123/336 (36%), Gaps = 26/336 (7%) Query: 6 LYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQ 65 LY SE + D HY K + D Sbjct: 161 LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT 220 Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +G G G V VA+K L ++ + +E +MK + H N++ Sbjct: 221 MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQ 277 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHL 180 LL V T + Y++ E M NL ++ E++ + Y+ Q+ +++L Sbjct: 278 LLGVCTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 331 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYRAPEVILG 237 IHR+L N +V + +K+ DFGL+R T T + + APE + Sbjct: 332 EKKNFIHRNLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAY 390 Query: 238 MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMKKLQP 292 + D+W+ G ++ E+ +PG D + + + CPE + +L Sbjct: 391 NKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 450 Query: 293 TVRNY-VENRPKYAGL--TFPKLFPDSLFPADSEHN 325 + +RP +A + F +F +S + E Sbjct: 451 ACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKE 486 >3PPZ-A nrPDB Length = 309 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 116/282 (41%), Gaps = 24/282 (8%) Query: 42 SKVDNQFYSVEVGDSTFTVLK-RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ 100 +N ++ + + + IG+G+ G V A D VA+K L Sbjct: 16 PTTENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSD--VAVKILMEQDF 73 Query: 101 NQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM 159 + RE+ +MK + H NI+ + T L +V E + +L +++ Sbjct: 74 HAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLS------IVTEYLSRGSLYRLLHK 127 Query: 160 -----ELDHERMSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLAR 212 +LD R + Y + G+ +LH+ I+HRDLK N++V T+K+ DFGL+R Sbjct: 128 SGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSR 187 Query: 213 TAGTSFM-MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 ++F+ T + APEV+ E D++S G I+ E+ + + + Sbjct: 188 LKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQV 247 Query: 272 WNKV------IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGL 307 V +E P+ ++ N RP +A + Sbjct: 248 VAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATI 289 >2J0K-A nrPDB Length = 656 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 107/263 (40%), Gaps = 23/263 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKC 117 +R + + IG G G V + VAIK + ++ +E + M+ Sbjct: 389 RERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSV-REKFLQEALTMRQ 447 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELDHERMSYLLYQM 173 +H +I+ L+ V T V+++MEL + QV + LD + YQ+ Sbjct: 448 FDHPHIVKLIGVITE-------NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQL 500 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYRA 231 + +L S +HRD+ N++V + +K+ DFGL+R S + A Sbjct: 501 STALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMA 560 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKI-LFPGRDYIDQWNKVI--EQLGTP--CPEF 286 PE I + D+W G M E++ H + F G D ++ E+L P CP Sbjct: 561 PESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 620 Query: 287 MKKLQPTVRNY-VENRPKYAGLT 308 + L Y RP++ L Sbjct: 621 LYSLMTKCWAYDPSRRPRFTELK 643 >4UY9-A nrPDB Length = 323 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 115/298 (38%), Gaps = 32/298 (10%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA--KRAYRELVLMKCVNHKN 122 + IG G G V A+ VA+K + +E L + H N Sbjct: 12 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 69 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHL 180 II+L V + L LVME + + + + Q+ G+ +L Sbjct: 70 IIALRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 123 Query: 181 HSAGI---IHRDLKPSNIVVK--------SDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 H I IHRDLK SNI++ S+ LKI DFGLAR + M+ T + Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAW 182 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-----YIDQWNKVIEQLGTPCP 284 APEVI + + D+WS G ++ E++ ++ F G D Y NK+ + + CP Sbjct: 183 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 242 Query: 285 EFMKKLQPTVRN-YVENRPKYAGL--TFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 E KL N +RP + + + F + + + +M Sbjct: 243 EPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEM 300 >6NPU-A nrPDB Length = 298 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 112/273 (41%), Gaps = 26/273 (9%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V VA+K L ++ + +E +MK + H N++ LL Sbjct: 33 KLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLG 89 Query: 129 VFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKHLHSA 183 V T + Y++ E M NL ++ E++ + Y+ Q+ +++L Sbjct: 90 VCTREPPF------YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 143 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYRAPEVILGMGY 240 IHRDL N +V + +K+ DFGL+R T T + + APE + + Sbjct: 144 NFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNKF 202 Query: 241 KENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMKKLQPTVR 295 D+W+ G ++ E+ +PG D + + + CPE + +L Sbjct: 203 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 262 Query: 296 NY-VENRPKYAGL--TFPKLFPDSLFPADSEHN 325 + +RP +A + F +F +S + E Sbjct: 263 QWNPSDRPSFAEIHQAFETMFQESSISDEVEKE 295 >3PFQ-A nrPDB Length = 674 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 118/346 (34%), Gaps = 61/346 (17%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR- 110 G+ L + L +G G+ G V + D A+K L + Q Sbjct: 331 NNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV 390 Query: 111 ELVLMKC-VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERM 166 E ++ + L + F L Y VME ++ +L IQ Sbjct: 391 EKRVLALPGKPPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHA 444 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVV 225 + ++ G+ L S GII+RDLK N+++ S+ +KI DFG+ + + Sbjct: 445 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG 504 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y APE+I Y ++VD W+ G ++ EM+ + F G D + + ++E Sbjct: 505 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH------- 557 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + + K + +A + ++ P Sbjct: 558 -----------------------------------NVAYPKSMSKEAVAICKGLMTKHPG 582 Query: 346 KRISV-----DDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDERE 384 KR+ D +H + W E PP E Sbjct: 583 KRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRNAE 628 >3TKU-A nrPDB Length = 433 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 71/385 (18%), Positives = 145/385 (37%), Gaps = 60/385 (15%) Query: 24 FDKQVDVSYIAKHYNMSKSKVDNQF------YSVEVGDSTFTVLKRYQNLKPIGSGAQGI 77 D V + H + + K +F ++ V + + ++ +K IG GA G Sbjct: 47 LDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLH-REDFEIIKVIGRGAFGE 105 Query: 78 VCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV-LMKCVNHKNIISLLNVFTPQKTL 136 V +R A+K L++ + +RE ++ + + I +L F + L Sbjct: 106 VAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHL 165 Query: 137 EEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 D Y+ +L+ L + +L + + + +M+ I +H +HRD+KP N++ Sbjct: 166 YLVMDYYVGGDLL--TLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVL 223 Query: 197 VKSDCTLKILDFGLARTAGTSFMMTP--YVVTRYYRAPEVILGM-----GYKENVDIWSV 249 + + +++ DFG + V T Y +PE++ M Y D WS+ Sbjct: 224 LDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSL 283 Query: 250 GCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTF 309 G M EM+ + F ++ + K++ E R ++ Sbjct: 284 GVCMYEMLYGETPFYAESLVETYGKIMNH--------------------EERFQFPS--- 320 Query: 310 PKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---SVDDALQHPYIN--VWYD 364 H + +A+DL+ + L+ +R+ ++D +H + W + Sbjct: 321 --------------HVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKHAFFEGLNWEN 365 Query: 365 PAEVEAPPPQIYDKQLDEREHTIEE 389 +EAP D +++ Sbjct: 366 IRNLEAPYIPDVSSPSDTSNFDVDD 390 >3VN9-A nrPDB Length = 340 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 69/324 (21%), Positives = 133/324 (41%), Gaps = 59/324 (18%) Query: 51 VEVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 + +G+ F V + + +G GA G+V + +A+K++ R N KR Sbjct: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLL 97 Query: 110 RELVL-MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD------ 162 +L + M+ V+ ++ + DV++ MELMD +L + + +D Sbjct: 98 MDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIP 151 Query: 163 HERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 + + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ S T Sbjct: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 Query: 222 PYVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIE 277 + Y APE I GY DIWS+G M E+ + FP + + ++ + Sbjct: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQ 269 Query: 278 QLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 + P P+ +++ D S Sbjct: 270 VVEEPSPQLP-------------------------------------ADKFSAEFVDFTS 292 Query: 338 KMLVIDPAKRISVDDALQHPYINV 361 + L + +R + + +QHP+ + Sbjct: 293 QCLKKNSKERPTYPELMQHPFFTL 316 >6CCF-A nrPDB Length = 290 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 137/331 (41%), Gaps = 74/331 (22%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA--------------- 105 L +Y+ IG GA G+V AY+ DR+ A+K LS+ + + Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 106 ---------KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV 156 +R Y+E+ ++K ++H N++ L+ V ++YLV +L+ Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVME 119 Query: 157 I--QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA 214 + E+ L ++ G+++LH I+HRD+KPSN+++ D +KI DFG++ Sbjct: 120 VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 179 Query: 215 -GTSFMMTPYVVTRYYRAPEVILGMGYK---ENVDIWSVGCIMGEMVRHKILFPGRDYID 270 G ++ T + APE I G + +D+W+ G + V K F Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF------- 232 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 +F+ L ++N P +FP+ + Sbjct: 233 ------------IDDFILALHRKIKNE------------PVVFPEE---------PEISE 259 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPYINV 361 + +DL+ KML +P RI V D HP++ Sbjct: 260 ELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >2WQN-A nrPDB Length = 310 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 70/271 (25%), Positives = 117/271 (43%), Gaps = 23/271 (8%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYREL 112 D + L ++ K IG G V A + VA+KK+ + +E+ Sbjct: 24 PDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEI 83 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ------MELDHER 165 L+K +NH N+I F E ++ +V+EL D +L ++I+ + Sbjct: 84 DLLKQLNHPNVIKYYASFI------EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERT 137 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-SFMMTPYV 224 + Q+ ++H+HS ++HRD+KP+N+ + + +K+ D GL R + + V Sbjct: 138 VWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLV 197 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-YIDQWNKVIEQLGTPC 283 T YY +PE I GY DIWS+GC++ EM + F G + K IEQ P Sbjct: 198 GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPP 257 Query: 284 -------PEFMKKLQPTVRNYVENRPKYAGL 307 E + + + E RP + Sbjct: 258 LPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288 >2I0E-A nrPDB Length = 353 Score = 214 bits (544), Expect = 8e-56, Method: Composition-based stats. Identities = 68/338 (20%), Positives = 117/338 (34%), Gaps = 61/338 (18%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR- 110 G+ L + L +G G+ G V + D A+K L + Q Sbjct: 10 NNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMV 69 Query: 111 ELVLMKC-VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM--ELDHERM 166 E ++ + L + F L Y VME ++ +L IQ Sbjct: 70 EKRVLALPGKPPFLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHA 123 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVV 225 + ++ G+ L S GII+RDLK N+++ S+ +KI DFG+ + + Sbjct: 124 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG 183 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y APE+I Y ++VD W+ G ++ EM+ + F G D + + ++E Sbjct: 184 TPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH------- 236 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + + K + +A + ++ P Sbjct: 237 -----------------------------------NVAYPKSMSKEAVAICKGLMTKHPG 261 Query: 346 KRISV-----DDALQHPYIN--VWYDPAEVEAPPPQIY 376 KR+ D +H + W E PP Sbjct: 262 KRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 299 >4UYA-A nrPDB Length = 340 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 115/284 (40%), Gaps = 33/284 (11%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +N ++ G +R + + IG+G G V A + VA+K + + Sbjct: 12 ENLYFQ---GSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAA 66 Query: 105 A--KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIQME 160 A + RE L + H NII L V Q + LV+E + Sbjct: 67 AAAESVRREARLFAMLRHPNIIELRGVCLQQP------HLCLVLEFARGGALNRALAGRR 120 Query: 161 LDHERMSYLLYQMLCGIKHLHSAG---IIHRDLKPSNIVVKS--------DCTLKILDFG 209 + + Q+ G+ +LH I+HRDLK SNI++ + TLKI DFG Sbjct: 121 IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFG 180 Query: 210 LARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-- 267 LAR + M + APEVI + + DIWS G ++ E++ ++ + G D Sbjct: 181 LAREWHRTTKMAT-AGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 Query: 268 ---YIDQWNKVIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGL 307 Y NK+ + + CPE KL RP +A + Sbjct: 240 AVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALI 283 >4AW2-A nrPDB Length = 437 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 126/342 (36%), Gaps = 53/342 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV-LMKCVN 119 + ++ LK IG GA G V D+ A+K L++ + +RE ++ + Sbjct: 73 REDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 179 K I +L F L D Y+ +L+ L + L E + L +M+ I Sbjct: 133 SKWITTLHYAFQDDNNLYLVMDYYVGGDLL--TLLSKFEDRLPEEMARFYLAEMVIAIDS 190 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP--YVVTRYYRAPEVIL- 236 +H +HRD+KP NI++ + +++ DFG + V T Y +PE++ Sbjct: 191 VHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQA 250 Query: 237 ----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 Y D WS+G M EM+ + F ++ + K++ Sbjct: 251 MEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN--------------- 295 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---S 349 FP D + A+DL+ + L+ R+ Sbjct: 296 ----------HKERFQFPTQVTD------------VSENAKDLIRR-LICSREHRLGQNG 332 Query: 350 VDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 ++D +HP+ + W + EAP D +++ Sbjct: 333 IEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDD 374 >6CQF-A nrPDB Length = 297 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 115/303 (37%), Gaps = 52/303 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Y L+ +G G G V A D V VA+K + + +E++++K H Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK--MEPDDDVSTLQKEILILKTCRH 72 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM---ELDHERMSYLLYQMLCGI 177 NI++ + Q +++ ME A Q I L ++SY+ ++L G+ Sbjct: 73 ANIVAYHGSYL------WLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGL 126 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT-PYVVTRYYRAPE--- 233 +LHS IHRD+K +NI++ +++ DFG++ G + ++ T Y+ APE Sbjct: 127 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAA 186 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V L GY E DIWS+G E+ + + + + P Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQP----------- 235 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 P E K ++ + + L P KR S Sbjct: 236 -------------------------PRLKEKGKW-SAAFHNFIKVTLTKSPKKRPSATKM 269 Query: 354 LQH 356 L H Sbjct: 270 LSH 272 >5FET-A nrPDB Length = 847 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 83/356 (23%), Positives = 138/356 (38%), Gaps = 63/356 (17%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF---QNQTHAK 106 +++ D+ + + + + IG G G V + A+K +S+ NQ + Sbjct: 522 RIKMQDTKVEMHE-LETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNI 580 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDH 163 + RE+ +H II L+ F Y + EL+ L I+ L Sbjct: 581 KLEREIT--AENDHPFIIRLVRTFKDSNCF------YFLTELVTGGELYDAIRKLGLLSK 632 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY 223 + + L ++ I++LH I++RDLKP NI++ +K++DFG A+ Sbjct: 633 PQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI--QGRAYTL 690 Query: 224 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 V T +Y APEVILG GY VDIW++G + E + + F G D DQ + + T Sbjct: 691 VGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLE-IFRDILT-- 746 Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 LTFP D + +L+ ++L Sbjct: 747 ---------------------GQLTFPDYVSD--------------QDSINLMKRLLCRL 771 Query: 344 PAKRISV-----DDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKE 392 P RI D +H + W A PP + + + I++ +E Sbjct: 772 PQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIEE 827 >4WUA-A nrPDB Length = 401 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 91/384 (23%), Positives = 149/384 (38%), Gaps = 84/384 (21%) Query: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 ++ V++GD RY ++ +G G V ++D + VA+K + + + + Sbjct: 30 YHLVKIGD---LFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTET 83 Query: 108 AYRELVLMKCV-----NHKN---IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-- 157 A E+ L+K V N N ++ LL+ F + +V E++ +L + I Sbjct: 84 ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWIIK 141 Query: 158 --QMELDHERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVK---------------- 198 L + ++ Q+L G+ +LH+ IIH D+KP NI++ Sbjct: 142 SNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEW 201 Query: 199 ---------------------------------SDCTLKILDFGLARTAGTSFMMTPYVV 225 +KI D G A F T + Sbjct: 202 QRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHF--TEDIQ 259 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP---GRDYI---DQWNKVIEQL 279 TR YR+ EV++G GY DIWS C+ E+ LF G +Y D +IE L Sbjct: 260 TRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELL 319 Query: 280 GTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQA---RDLL 336 G P + + + + +T KL P LF E + +A D L Sbjct: 320 GK-VPRKLIVAGKYSKEFFTKKGDLKHIT--KLKPWGLFEVLVEKYEWSQEEAAGFTDFL 376 Query: 337 SKMLVIDPAKRISVDDALQHPYIN 360 ML + P KR + + L+HP++N Sbjct: 377 LPMLELIPEKRATAAECLRHPWLN 400 >6E2O-A nrPDB Length = 295 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 82/328 (25%), Positives = 137/328 (41%), Gaps = 63/328 (19%) Query: 50 SVEVGDSTFTVLK-RYQNLK-----PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103 S E GD +L+ Y+ + +G G GIV A D +AIK++ P ++ Sbjct: 4 STEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSR 61 Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL-- 161 +++ + E+ L K + HKNI+ L F+ ++ + ME + + Sbjct: 62 YSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIK------IFMEQVPGGSLSALLRSKWG 115 Query: 162 ----DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLA-RTAG 215 + + + + Q+L G+K+LH I+HRD+K N+++ + LKI DFG + R AG Sbjct: 116 PLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG 175 Query: 216 TSFMMTPYVVTRYYRAPEVILG--MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 + + T Y APE+I GY + DIWS+GC + EM K F Sbjct: 176 INPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY--------- 226 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQAR 333 +LG P +F +F E + +++A+ Sbjct: 227 ----ELGEP--------------------------QAAMFKVGMFKVHPEIPESMSAEAK 256 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINV 361 + K DP KR +D L ++ V Sbjct: 257 AFILKCFEPDPDKRACANDLLVDEFLKV 284 >3DKO-A nrPDB Length = 318 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 106/260 (40%), Gaps = 24/260 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + + IG+G G VC+ + + VAIK L + + + E +M +H Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHP 104 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE----RMSYLLYQMLCGI 177 N++ L V T K V +V+E M+ + D + ++ +L + G+ Sbjct: 105 NVVHLEGVVTRGKP------VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 158 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPE 233 ++L G +HRDL NI+V S+ K+ DFGL+R + T + + APE Sbjct: 159 RYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 218 Query: 234 VILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIEQLGTP----CPEFMK 288 I + D+WS G +M E M + + D + E P CP + Sbjct: 219 AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLH 278 Query: 289 KLQPTVRNYVE-NRPKYAGL 307 +L RPK+ + Sbjct: 279 QLMLDCWQKERAERPKFEQI 298 >4C0T-A nrPDB Length = 974 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 81/412 (19%), Positives = 152/412 (36%), Gaps = 76/412 (18%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHK 121 ++ K +G G+ V A D + + A+K L + + K E + ++ Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLS-- 324 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM--ELDHERMSYLLYQMLCGIK 178 + L V + T ++ +Y V++ + L +I+ L+ E + Q+L IK Sbjct: 325 ---NRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIK 381 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT----------SFMMTPYVVTRY 228 ++H G+IHRDLKP NI++ ++I DFG AR +V T Sbjct: 382 YMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y +PE++ + D+W+ GCI+ +M+ K F + + K+ + Sbjct: 442 YVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL---------- 491 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 F FP + RDL+ K+LV+ P++R Sbjct: 492 -----------------QFAFSAGFPTII---------------RDLIKKILVLQPSRRA 519 Query: 349 SVDDALQHPYIN----VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 ++ + +H + +D + PP K + + E + V+ K Sbjct: 520 TIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPELNKAPITTVIKKNVK 579 Query: 405 TKN---------GVVKGQPSPSGA--AVNSSESLPPSSSVNDISSMSTDQTL 445 G S +G + + E P +++N+ S+ Sbjct: 580 KSTNSNSNTNNVATAVGGSSSNGHKGSSPTPEKEPSPATINNKSTEKVSAAS 631 >3DTC-A nrPDB Length = 271 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 71/264 (26%), Positives = 107/264 (40%), Gaps = 30/264 (11%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA--KRAYRELVLMKCVNHKN 122 + IG G G V A+ VA+K + +E L + H N Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCGIKHL 180 II+L V + L LVME + + + + Q+ G+ +L Sbjct: 68 IIALRGVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 121 Query: 181 HSAGI---IHRDLKPSNIVVK--------SDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 H I IHRDLK SNI++ S+ LKI DFGLAR + M+ + Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAW 180 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRD-----YIDQWNKVIEQLGTPCP 284 APEVI + + D+WS G ++ E++ ++ F G D Y NK+ + + CP Sbjct: 181 MAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCP 240 Query: 285 EFMKKLQPTVRN-YVENRPKYAGL 307 E KL N +RP + + Sbjct: 241 EPFAKLMEDCWNPDPHSRPSFTNI 264 >4FR4-A nrPDB Length = 384 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 76/347 (21%), Positives = 135/347 (38%), Gaps = 54/347 (15%) Query: 52 EVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT-HAKRAY 109 V D V ++ L+ IG G+ G VC + A+K +++ + + + Sbjct: 4 PVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVF 63 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--ELDHERMS 167 +EL +M+ + H +++L F ++ + D+ L+ +L +Q E + Sbjct: 64 KELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDL-----LLGGDLRYHLQQNVHFKEETVK 118 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 + +++ + +L + IIHRD+KP NI++ + I DF +A +T T+ Sbjct: 119 LFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTK 178 Query: 228 YYRAPEVI---LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y APE+ G GY VD WS+G E++R + + R T Sbjct: 179 PYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRS------------STSSK 226 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 E + + TV Y + + LL K+L +P Sbjct: 227 EIVHTFETTVVTYPS---------------------------AWSQEMVSLLKKLLEPNP 259 Query: 345 AKRIS-VDDALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTIE 388 +R S + D PY+N W + P I +K + T E Sbjct: 260 DQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFE 306 >5L6P-A nrPDB Length = 298 Score = 211 bits (538), Expect = 5e-55, Method: Composition-based stats. Identities = 65/262 (24%), Positives = 105/262 (40%), Gaps = 26/262 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + + IG+G G VC R VAIK L + + + E +M +H Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQFDHP 80 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHERMSYLLYQMLCGI 177 NII L V T + V ++ E M+ + ++ + ++ +L + G+ Sbjct: 81 NIIRLEGVVTKSRP------VMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 134 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV------VTRYYRA 231 K+L +HRDL NI+V S+ K+ DFGL+R Y + + A Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 194 Query: 232 PEVILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIEQLGTP----CPEF 286 PE I + D+WS G +M E M + + D N V + P CP Sbjct: 195 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTA 254 Query: 287 MKKLQPTVRNYVEN-RPKYAGL 307 + +L N RPK++ + Sbjct: 255 LHQLMLDCWVRDRNLRPKFSQI 276 >1JPA-A nrPDB Length = 312 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 63/262 (24%), Positives = 107/262 (40%), Gaps = 26/262 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + + IG+G G VC+ + + + VAIK L + + + E +M +H Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQRRDFLSEASIMGQFDHP 94 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM---ELDHERMSYLLYQMLCGI 177 N+I L V T V ++ E M+ +L ++ + ++ +L + G+ Sbjct: 95 NVIHLEGVVTKSTP------VMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 148 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV------VTRYYRA 231 K+L +HRDL NI+V S+ K+ DFGL+R Y + + A Sbjct: 149 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 208 Query: 232 PEVILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIEQLGTP----CPEF 286 PE I + D+WS G +M E M + + D N + + P CP Sbjct: 209 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSA 268 Query: 287 MKKLQPTVRNYVEN-RPKYAGL 307 + +L N RPK+ + Sbjct: 269 LHQLMLDCWQKDRNHRPKFGQI 290 >5X5O-A nrPDB Length = 310 Score = 211 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 120/297 (40%), Gaps = 33/297 (11%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 Q + G G+ G V A D+ VA+KKL + +E ++ ++H+ Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHR 64 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM----ELDHERMSYLLYQMLCG 176 NII V E + +V E +L I E+D + + + G Sbjct: 65 NIIQFYGVIL------EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 118 Query: 177 IKHLHSA---GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 + +LH +IHRDLK N+V+ +D LKI DFG +R + M V T + APE Sbjct: 119 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPE 177 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-----LGTPCPEFMK 288 VI + E D +S G ++ EM+ ++ F G + + V+E+ + + CP Sbjct: 178 VIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFA 237 Query: 289 KLQPTVRN-YVENRPKYAGL--TFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 +L + RP + + + D+ P ++ R + L Sbjct: 238 ELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLER 294 >5MJB-A nrPDB Length = 305 Score = 211 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 61/262 (23%), Positives = 107/262 (40%), Gaps = 26/262 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + + IG+G G V + + VAIK L + ++ + E +M +H+ Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHR 87 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHERMSYLLYQMLCGI 177 NII L V T + V ++ E M+ + + + ++ +L + G+ Sbjct: 88 NIIRLEGVVTKSRP------VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV------VTRYYRA 231 K+L +HRDL NI+V S+ K+ DFGL+R Y + + A Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 201 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEF 286 PE I + D+WS G +M E++ + + D N + + P CP Sbjct: 202 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAA 261 Query: 287 MKKLQPTVRNYVEN-RPKYAGL 307 + +L N RP++A + Sbjct: 262 LHQLMLDCWQKDRNSRPRFAEI 283 >5H2U-A nrPDB Length = 267 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 72/259 (27%), Positives = 115/259 (44%), Gaps = 21/259 (8%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + + + +GSG G V VAIK +SR N H + E+ MK + H Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRD--NLLHQQMLQSEIQAMKKLRH 61 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 175 K+I++L V + VY++ ELM +L ++++ L + + +Q+ Sbjct: 62 KHILALYAVVSVGDP------VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAE 115 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY-YRAPEV 234 G+ +L S IHRDL NI+V + K+ DFGLAR ++ Y + APE Sbjct: 116 GMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEA 175 Query: 235 ILGMGYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTP----CPEFMKK 289 + Y D+WS G ++ EM R ++ +PG + + +V P CP + K Sbjct: 176 LSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK 235 Query: 290 LQPTVR-NYVENRPKYAGL 307 L T E RP + L Sbjct: 236 LMLTCWCRDPEQRPTFKAL 254 >2XNP-A nrPDB Length = 279 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 112/269 (41%), Gaps = 17/269 (6%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + Y+ L IG+G+ G + + K+L + + E+ L++ + H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVI------QMELDHERMSYLLYQML 174 NI+ + + +Y+VME + +L VI + LD E + ++ Q+ Sbjct: 66 NIVRYYDRIIDRTN----TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 175 CGIKHLHSAG-----IIHRDLKPSNIVVKSDCTLKILDFGLARTA-GTSFMMTPYVVTRY 228 +K H ++HRDLKP+N+ + +K+ DFGLAR + +V T Y Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 Y +PE + M Y E DIWS+GC++ E+ F + K+ E P Sbjct: 182 YMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYS 241 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSL 317 + + N Y + ++ + L Sbjct: 242 DELNEIITRMLNLKDYHRPSVEEILENPL 270 >3ALO-A nrPDB Length = 327 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 64/322 (19%), Positives = 119/322 (36%), Gaps = 55/322 (17%) Query: 54 GDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 + + + ++L IG GA G V + +A+K++ + + Sbjct: 13 PEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD 72 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-------LDHER 165 V+M+ + I+ + D ++ MELM + + + + E Sbjct: 73 VVMRSSDCPYIVQFYGALFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEI 126 Query: 166 MSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 224 + + + + HL IIHRD+KPSNI++ +K+ DFG++ S T Sbjct: 127 LGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA 186 Query: 225 VTRYYRAPEVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 R Y APE I GY D+WS+G + E+ + +P +WN V +QL Sbjct: 187 GCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP------KWNSVFDQLT 240 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 +L + + + + ++ L Sbjct: 241 QVVKGDPPQLSNS------------------------------EEREFSPSFINFVNLCL 270 Query: 341 VIDPAKRISVDDALQHPYINVW 362 D +KR + L+HP+I ++ Sbjct: 271 TKDESKRPKYKELLKHPFILMY 292 >4YHJ-A nrPDB Length = 584 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 72/361 (19%), Positives = 130/361 (36%), Gaps = 64/361 (17%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 Y Y S+ V +T +++ + +G G G VCA + Sbjct: 161 EYQESSY-FSQFLQWKWLERQPVTKNT------FRHYRVLGKGGFGEVCACQVRATGKMY 213 Query: 91 AIKKLSRPFQNQTHAKR-AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 A KKL + + + A E +++ V + ++SL + + L LV+ +M Sbjct: 214 ACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDAL------CLVLTIM 267 Query: 150 DANLCQVI-----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 + + D +R + ++ CG++ L I++RDLKP NI++ ++ Sbjct: 268 NGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIR 327 Query: 205 ILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 I D GLA + V T Y APEV+ Y + D W +GC++ EM++ F Sbjct: 328 ISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFK 387 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 +W +V +++ E+ +K Sbjct: 388 KYKEKVKWEEVDQRIKNDTEEYSEKF---------------------------------- 413 Query: 325 NKLKASQARDLLSKMLVIDPAKRI-----SVDDALQHPYINV--WYDPAEVEAPPPQIYD 377 + A+ + +L +P+KR+ QHP + PP D Sbjct: 414 ----SEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPD 469 Query: 378 K 378 Sbjct: 470 P 470 >4E93-A nrPDB Length = 377 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 109/291 (37%), Gaps = 20/291 (6%) Query: 30 VSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRN 89 + ++ K + D + + IG G G V + + Sbjct: 82 IDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTL 141 Query: 90 VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM 149 VA+K AK +E ++K +H NI+ L+ V T + Q +Y+VMEL+ Sbjct: 142 VAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVCTQK------QPIYIVMELV 194 Query: 150 -DANLCQVIQMELDHERMSYLLYQM---LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 205 + ++ E R+ LL + G+++L S IHRDL N +V LKI Sbjct: 195 QGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKI 254 Query: 206 LDFGLARTAGTSFMMTP---YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKI 261 DFG++R V + APE + Y D+WS G ++ E Sbjct: 255 SDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGAS 314 Query: 262 LFPGRDYIDQWNKVIEQLGTPCPEF----MKKLQPTVRNY-VENRPKYAGL 307 +P V + PCPE + +L Y RP ++ + Sbjct: 315 PYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTI 365 >2Y6O-A nrPDB Length = 291 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 64/260 (24%), Positives = 103/260 (39%), Gaps = 24/260 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + K IG G G VC+ V + VAIK L + ++ + E +M +H Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK-QRRDFLSEASIMGQFDHP 75 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE----RMSYLLYQMLCGI 177 NII L V T K V ++ E M+ + D ++ +L + G+ Sbjct: 76 NIIHLEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 129 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPE 233 K+L +HRDL NI+V S+ K+ DFG++R + + + APE Sbjct: 130 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 189 Query: 234 VILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIEQLGTP----CPEFMK 288 I + D+WS G +M E M + + D + E P CP + Sbjct: 190 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALH 249 Query: 289 KLQPTVR-NYVENRPKYAGL 307 +L +RPK+ + Sbjct: 250 QLMLDCWQKERSDRPKFGQI 269 >4AN9-A nrPDB Length = 301 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 124/312 (39%), Gaps = 53/312 (16%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++ + +G+G G+V +A K + + + REL ++ N Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 67 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCGIK 178 I+ F ++ + ME MD L QV++ + + + + ++ G+ Sbjct: 68 YIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 179 HL-HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 +L I+HRD+KPSNI+V S +K+ DFG++ M +V TR Y +PE + G Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPERLQG 180 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Y DIWS+G + EM + P + + ++ Sbjct: 181 THYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN-------------------- 220 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 P P ++F + + +D ++K L+ +PA+R + + H Sbjct: 221 ----------EPPPKLPSAVF----------SLEFQDFVNKCLIKNPAERADLKQLMVHA 260 Query: 358 YINVWYDPAEVE 369 +I D EV+ Sbjct: 261 FIKR-SDAEEVD 271 >2R2P-A nrPDB Length = 295 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 105/260 (40%), Gaps = 24/260 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + IG+G G VC+ + + VAIK L + + + E +M +H Sbjct: 25 TIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHP 83 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE----RMSYLLYQMLCGI 177 NII L V T K V +V E M+ + D + ++ +L + G+ Sbjct: 84 NIIHLEGVVTKSKP------VMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGM 137 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPE 233 K+L G +HRDL NI++ S+ K+ DFGL+R + + + APE Sbjct: 138 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 197 Query: 234 VILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMK 288 I + D+WS G +M E+V + + D V E P CP + Sbjct: 198 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALY 257 Query: 289 KLQPTVRNYVEN-RPKYAGL 307 +L N RPK+ + Sbjct: 258 QLMLDCWQKERNSRPKFDEI 277 >3TT0-A nrPDB Length = 382 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 111/290 (38%), Gaps = 44/290 (15%) Query: 55 DSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLDR-------NVAIKKLSRPFQNQTHAK 106 D + + R KP+G GA G V A LD+ VA+K L + Sbjct: 61 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLS 119 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME---- 160 E+ +MK + HKNII+LL T L Y+++E NL + +Q Sbjct: 120 DLISEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKGNLREYLQARRPPG 173 Query: 161 --------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 L + + YQ+ G+++L S IHRDL N++V D +KI Sbjct: 174 LEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 233 Query: 207 DFGLARTAGT---SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKIL 262 DFGLAR T + + APE + Y D+WS G ++ E+ Sbjct: 234 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 293 Query: 263 FPGRDYIDQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 +PG + + + E P E ++ RP + L Sbjct: 294 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 343 >4P5Q-A nrPDB Length = 361 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 104/259 (40%), Gaps = 24/259 (9%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 K +G+G G VC+ + + VAIK L + + + E +M +H N Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHPN 95 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE----RMSYLLYQMLCGIK 178 II L V T K V +V E M+ + D + ++ +L + G+K Sbjct: 96 IIRLEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMK 149 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPEV 234 +L G +HRDL NI++ S+ K+ DFGL+R + + + +PE Sbjct: 150 YLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEA 209 Query: 235 ILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIEQLGTP----CPEFMKK 289 I + D+WS G ++ E M + + D V E P CP + + Sbjct: 210 IAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQ 269 Query: 290 LQPTVRNYVE-NRPKYAGL 307 L NRPK+ + Sbjct: 270 LMLDCWQKDRNNRPKFEQI 288 >3C51-A nrPDB Length = 543 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 78/355 (21%), Positives = 135/355 (38%), Gaps = 66/355 (18%) Query: 41 KSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ 100 + + +G+ F + + +G G G V A + A KKL++ Sbjct: 170 RFLQWKWLEAQPMGEDWFL------DFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRL 223 Query: 101 NQTHA-KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM 159 + + A E ++ V+ + I+SL F + D+ LVM +M+ + Sbjct: 224 KKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETK------TDLCLVMTIMNGGDIRYHIY 277 Query: 160 ELDHE-------RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 +D + R + Q++ G++HLH II+RDLKP N+++ D ++I D GLA Sbjct: 278 NVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAV 337 Query: 213 TAGTSFMMT-PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 T Y T + APE++LG Y +VD +++G + EM+ + F R + Sbjct: 338 ELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVE 397 Query: 272 WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQ 331 ++ R +T+P F + Sbjct: 398 -----------------------NKELKQRVLEQAVTYPDKF---------------SPA 419 Query: 332 ARDLLSKMLVIDPAKRI-----SVDDALQHPYINV--WYDPAEVEAPPPQIYDKQ 379 ++D +L DP KR+ S D HP W PP + D + Sbjct: 420 SKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSR 474 >2DQ7-X nrPDB Length = 283 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 107/256 (41%), Gaps = 24/256 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 Q +K +G+G G V + VAIK L + + E +MK + H ++ Sbjct: 12 QLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS---PESFLEEAQIMKKLKHDKLV 67 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ----MELDHERMSYLLYQMLCGIKH 179 L V + + +Y+V E M+ +L ++ L + + Q+ G+ + Sbjct: 68 QLYAVVSEEP-------IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 120 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYRAPEVILG 237 + IHRDL+ +NI+V + KI DFGLAR + + APE L Sbjct: 121 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 180 Query: 238 MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE-----FMKKLQ 291 + D+WS G ++ E+V ++ +PG + + +V PCP+ + + Sbjct: 181 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 240 Query: 292 PTVRNYVENRPKYAGL 307 + E RP + L Sbjct: 241 HCWKKDPEERPTFEYL 256 >5HI2-A nrPDB Length = 283 Score = 207 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 125/292 (42%), Gaps = 45/292 (15%) Query: 36 HYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKL 95 H++ S+ D+ E+ D TV +R IGSG+ G V VA+K L Sbjct: 4 HHHGSRDSSDDW----EIPDGQITVGQR------IGSGSFGTVYKGKWHGD---VAVKML 50 Query: 96 SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LC 154 + E+ +++ H NI+ + T + + +V + + + L Sbjct: 51 -----TPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLY 98 Query: 155 QVIQ---MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA 211 + + + +++ + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA Sbjct: 99 HHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLA 158 Query: 212 RTAGT---SFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHKILFPG 265 S + + APEVI Y D+++ G ++ E++ ++ + Sbjct: 159 TVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSN 218 Query: 266 RDYIDQWNKVIEQ---------LGTPCPEFMKKLQPTV-RNYVENRPKYAGL 307 + DQ +++ + + + CP+ MK+L + + RP + + Sbjct: 219 INNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRI 270 >2BRG-A nrPDB Length = 297 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 123/309 (39%), Gaps = 53/309 (17%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 ++ + ++ +G GA G V A + V + VA+K + + +E+ + K +N Sbjct: 5 FVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDC-PENIKKEICINKMLN 63 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCG 176 H+N++ E YL +E L I+ + + +Q++ G Sbjct: 64 HENVVKFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAG 117 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA---RTAGTSFMMTPYVVTRYYRAPE 233 + +LH GI HRD+KP N+++ LKI DFGLA R ++ T Y APE Sbjct: 118 VVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPE 177 Query: 234 VILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 ++ + E VD+WS G ++ M+ ++ + Sbjct: 178 LLKRREFHAEPVDVWSCGIVLTAMLAGELP------------------------WDQPSD 213 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 + + Y + + K L K S LL K+LV +P+ RI++ D Sbjct: 214 SCQEYSDWKEKKTYLN---------------PWKKIDSAPLALLHKILVENPSARITIPD 258 Query: 353 ALQHPYINV 361 + + N Sbjct: 259 IKKDRWYNK 267 >4GS6-A nrPDB Length = 315 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 84/358 (23%), Positives = 141/358 (39%), Gaps = 72/358 (20%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 K + + +G GA G+VC A ++VAIK++ ++++ K EL + VNH Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHP 62 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELD-----HERMSYLLYQMLC 175 NI+ L V LVME + L V+ Q Sbjct: 63 NIVKLYGACL--------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 176 GIKHLHSAG---IIHRDLKPSNIVVKSDCTL-KILDFGLARTAGTSFMMTPYVVTRYYRA 231 G+ +LHS +IHRDLKP N+++ + T+ KI DFG A T MT + + A Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNKGSAAWMA 172 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 PEV G Y E D++S G I+ E++ + F +++G P M + Sbjct: 173 PEVFEGSNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVH 219 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 R P L + P +S L+++ DP++R S++ Sbjct: 220 NGTR--------------PPLIKNLPKPIES------------LMTRCWSKDPSQRPSME 253 Query: 352 D---ALQHPYINVWYDPAEVEAPPPQIYD--KQLDEREHTIEEWKELIYKEVMNSEEK 404 + + H + ++ A+ P + D R ++ E ++ E+ Sbjct: 254 EIVKIMTH--LMRYFPGADEPLQYPCQHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQ 309 >3GQL-A nrPDB Length = 326 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 111/290 (38%), Gaps = 44/290 (15%) Query: 55 DSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLDR-------NVAIKKLSRPFQNQTHAK 106 D + + R KP+G GA G V A LD+ VA+K L + Sbjct: 20 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLS 78 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME---- 160 E+ +MK + HKNII+LL T L Y+++E NL + +Q Sbjct: 79 DLISEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKGNLREYLQARRPPG 132 Query: 161 --------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 L + + YQ+ G+++L S IHRDL N++V D +KI Sbjct: 133 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 192 Query: 207 DFGLARTAGT---SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKIL 262 DFGLAR T + + APE + Y D+WS G ++ E+ Sbjct: 193 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 252 Query: 263 FPGRDYIDQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 +PG + + + E P E ++ RP + L Sbjct: 253 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 302 >2H8H-A nrPDB Length = 535 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 103/252 (40%), Gaps = 24/252 (9%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V R VAIK L + + +E +MK + H+ ++ L Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 129 VFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSA 183 V + + +Y+V E M +L ++ E L ++ + Q+ G+ ++ Sbjct: 330 VVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 382 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYRAPEVILGMGYK 241 +HRDL+ +NI+V + K+ DFGLAR + + APE L + Sbjct: 383 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 442 Query: 242 ENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE-----FMKKLQPTVR 295 D+WS G ++ E+ ++ +PG + ++V PCP + R Sbjct: 443 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 502 Query: 296 NYVENRPKYAGL 307 E RP + L Sbjct: 503 KEPEERPTFEYL 514 >6F3F-A nrPDB Length = 455 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 104/252 (41%), Gaps = 24/252 (9%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V R VAIK L + + +E +MK + H+ ++ L Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 129 VFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSA 183 V + + +Y+V E M+ +L ++ E L ++ + Q+ G+ ++ Sbjct: 250 VVSEEP-------IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM 302 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYRAPEVILGMGYK 241 +HRDL+ +NI+V + K+ DFGLAR + + APE L + Sbjct: 303 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 362 Query: 242 ENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE-----FMKKLQPTVR 295 D+WS G ++ E+ ++ +PG + ++V PCP + R Sbjct: 363 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 422 Query: 296 NYVENRPKYAGL 307 E RP + L Sbjct: 423 KEPEERPTFEYL 434 >1S9I-A nrPDB Length = 354 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 124/312 (39%), Gaps = 24/312 (7%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 ++ + +G+G G+V +A K + + + REL ++ N Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 74 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQ--MELDHERMSYLLYQMLCGIK 178 I+ F ++ + ME MD L QV++ + E + + +L G+ Sbjct: 75 YIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 179 HL-HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 +L I+HRD+KPSNI+V S +K+ DFG++ S +V TR Y APE + G Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPERLQG 187 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR-- 295 Y DIWS+G + E+ + P D + + + E Sbjct: 188 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 296 -------NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 + +++RP A + P N + ++ ++K L+ +PA+R Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNE--PPPKLPNGVFTPDFQEFVNKCLIKNPAERA 304 Query: 349 SVDDALQHPYIN 360 + H +I Sbjct: 305 DLKMLTNHTFIK 316 >5VO2-A nrPDB Length = 300 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 64/253 (25%), Positives = 105/253 (41%), Gaps = 26/253 (10%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 +L+ +GSGAQG V VA+KK+ + + ++ + H NII+ Sbjct: 16 DLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------IKHLRKLKHPNIIT 64 Query: 126 LLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHS 182 V T ++ME L +V++ + + + G+ +LH Sbjct: 65 FKGVCTQAP------CYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHL 118 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 IIHRDLK N+++ D +KI DFG ++ + T + APEVI E Sbjct: 119 HKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE 178 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQW-----NKVIEQLGTPCPEFMKKLQPTVRN- 296 VDIWS G ++ E++ +I + D N + + + CP+ K L N Sbjct: 179 KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNS 238 Query: 297 YVENRPKYAGLTF 309 NRP + + Sbjct: 239 KPRNRPSFRQILL 251 >5TQX-A nrPDB Length = 655 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 77/321 (23%), Positives = 124/321 (38%), Gaps = 39/321 (12%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D F ++ + +G+G G VC LD +AIK + +R E+ + Sbjct: 1 DPEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQI 59 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------LDHERMSY 168 MK +NH N++ +V L + L ME + + + L ++ Sbjct: 60 MKKLNHANVVKACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILS 118 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC---TLKILDFGLARTAGTSFMMTPYVV 225 LL + GI++LH IIHRDLKP NIV++ KI+D G A+ + T +V Sbjct: 119 LLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVG 178 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 T Y APE+ Y VD WS G ++ E + F W++ I++ C Sbjct: 179 TLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIF 238 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 +++ VR S P + L + L ML DP Sbjct: 239 ACEEMSGEVR------------------FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQ 280 Query: 346 KR-----ISVDD-----ALQH 356 +R +++ + H Sbjct: 281 QRGGPVDLTLKQPRCFVLMDH 301 >6DBM-A nrPDB Length = 318 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 125/328 (38%), Gaps = 43/328 (13%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCA-AYDA---VLDRNVAIKKLSRPFQNQTHAKRAY 109 GD T + + ++ +G G G V YD VA+K L Q H Sbjct: 23 GDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWK 81 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI-QMELDHERMS 167 +E+ +++ + H++II + LVME + +L + + + ++ Sbjct: 82 QEIDILRTLYHEHIIKYKGCCEDAGA----ASLQLVMEYVPLGSLRDYLPRHSIGLAQLL 137 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV--- 224 Q+ G+ +LHS IHRDL N+++ +D +KI DFGLA+ Sbjct: 138 LFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 197 Query: 225 -VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 ++ APE + + D+WS G + E++ H K +E +G Sbjct: 198 DSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG--- 249 Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 + + Q TV E + L P P ++ L+ + Sbjct: 250 ---IAQGQMTVLRLTELLERGERLPRPDKCP---------------AEVYHLMKNCWETE 291 Query: 344 PAKRISVDDALQHPYINVWYDPAEVEAP 371 + R + ++ + P + ++ + +AP Sbjct: 292 ASFRPTFENLI--PILKTVHEKYQGQAP 317 >3A4O-X nrPDB Length = 286 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 109/267 (40%), Gaps = 23/267 (8%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV 113 D+ + + +K +G+G G V Y VA+K L + + E Sbjct: 5 KDAWEIPRESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMS---VQAFLEEAN 60 Query: 114 LMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHE----RMSY 168 LMK + H ++ L V T ++ +Y++ E M +L ++ + + ++ Sbjct: 61 LMKTLQHDKLVRLYAVVTREEP------IYIITEYMAKGSLLDFLKSDEGGKVLLPKLID 114 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--T 226 Q+ G+ ++ IHRDL+ +N++V KI DFGLAR + Sbjct: 115 FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFP 174 Query: 227 RYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP--- 282 + APE I + D+WS G ++ E+V KI +PGR D + + P Sbjct: 175 IKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE 234 Query: 283 -CPEFMKKLQPTVRNYV-ENRPKYAGL 307 CP+ + + E RP + L Sbjct: 235 NCPDELYDIMKMCWKEKAEERPTFDYL 261 >4KIK-B nrPDB Length = 677 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 119/295 (40%), Gaps = 28/295 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ + +G+G G V ++ +AIK+ + + + +R E+ +M+ + H N+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMRRLTHPNV 79 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD------HERMSYLLYQMLCGI 177 ++ +V + L L ME + + + + LL + + Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 178 KHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV 234 ++LH IIHRDLKP NIV+ + KI+D G A+ + T +V T Y APE+ Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 199 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTV 294 + Y VD WS G + E + F QW+ + Q + L TV Sbjct: 200 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTV 259 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + + +P++L +E + L ML+ P +R + Sbjct: 260 K-----------FSSSLPYPNNLNSVLAERLEKW-------LQLMLMWHPRQRGT 296 >2PSQ-A nrPDB Length = 370 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 112/285 (39%), Gaps = 34/285 (11%) Query: 55 DSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAK 106 D + + KP+G G G V A +D++ VA+K L + + Sbjct: 73 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLS 131 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDV--------YL------VMELMDA 151 E+ +MK + HKNII+LL T L + YL ME Sbjct: 132 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY-SY 190 Query: 152 NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA 211 ++ +V + ++ + + YQ+ G+++L S IHRDL N++V + +KI DFGLA Sbjct: 191 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 250 Query: 212 RTAGT---SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRD 267 R T + + APE + Y D+WS G +M E+ +PG Sbjct: 251 RDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 310 Query: 268 YIDQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 + + + E P E ++ RP + L Sbjct: 311 VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 355 >5A46-A nrPDB Length = 386 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 110/290 (37%), Gaps = 44/290 (15%) Query: 55 DSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLDR-------NVAIKKLSRPFQNQTHAK 106 D + + R KP+G G G V A LD+ VA+K L + Sbjct: 32 DPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLS 90 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME---- 160 E+ +MK + HKNII+LL T L Y+++E NL + +Q Sbjct: 91 DLISEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKGNLREYLQARRPPG 144 Query: 161 --------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 L + + YQ+ G+++L S IHRDL N++V D +KI Sbjct: 145 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 204 Query: 207 DFGLARTAGT---SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKIL 262 DFGLAR T + + APE + Y D+WS G ++ E+ Sbjct: 205 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 264 Query: 263 FPGRDYIDQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 +PG + + + E P E ++ RP + L Sbjct: 265 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 314 >4OLI-A nrPDB Length = 645 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 66/327 (20%), Positives = 125/327 (38%), Gaps = 43/327 (13%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCA-AYDA---VLDRNVAIKKLSRPFQNQTHAKRAYR 110 D T + + ++ +G G G V YD VA+K L Q H + Sbjct: 346 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQ 404 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI-QMELDHERMSY 168 E+ +++ + H++II Q + + LVME + +L + + + ++ Sbjct: 405 EIDILRTLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLL 460 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV---- 224 Q+ G+ +LHS IHR+L N+++ +D +KI DFGLA+ Sbjct: 461 FAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGD 520 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 ++ APE + + D+WS G + E++ H K +E +G Sbjct: 521 SPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG---- 571 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 + + Q TV E + L P P + L+ + Sbjct: 572 --IAQGQMTVLRLTELLERGERLPRPDKCP---------------CEVYHLMKNCWETEA 614 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAP 371 + R + ++ + P + ++ + +AP Sbjct: 615 SFRPTFENLI--PILKTVHEKYQGQAP 639 Score = 92.8 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 91/285 (31%), Gaps = 41/285 (14%) Query: 81 AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQ 140 D + V +K L + A Y LM V+H ++ + V Sbjct: 88 GRDRGQELRVVLKVLDPSHHD--IALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--- 142 Query: 141 DVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 +V E ++ V + + + Q+ + +L + ++H ++ NI+ Sbjct: 143 ---MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 197 VKSDCT-------LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG--MGYKENVDIW 247 + +K+ D G+ A + + + APE + G +D W Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKW 256 Query: 248 SVGCIMGEM-VRHKILFPGR--DYIDQWNKVIEQLGTP-CPEFMKKLQPTVRNYVENRPK 303 G + E+ + R + + + +L P CP+ + RP Sbjct: 257 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 316 Query: 304 YAGL-------------TFPKLFPDSLFPADSEHNKLKASQARDL 335 + + + PDS + +K + RDL Sbjct: 317 FRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDL 361 >2PL0-A nrPDB Length = 289 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 113/287 (39%), Gaps = 30/287 (10%) Query: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 H K + EV T +++R +G+G G V Y VA+K Sbjct: 1 GSHMQTQKPQKPWWEDEWEVPRETLKLVER------LGAGQFGEVWMGYYNG-HTKVAVK 53 Query: 94 KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-AN 152 L Q E LMK + H+ ++ L V T + +Y++ E M+ + Sbjct: 54 SLK---QGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEP-------IYIITEYMENGS 103 Query: 153 LCQVIQM----ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 L ++ +L ++ + Q+ G+ + IHRDL+ +NI+V + KI DF Sbjct: 104 LVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADF 163 Query: 209 GLARTAGTSFMMTPYVV--TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPG 265 GLAR + + APE I + D+WS G ++ E+V +I +PG Sbjct: 164 GLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 Query: 266 RDYIDQWNKVIEQLGT----PCPEFMKKLQPTVRNY-VENRPKYAGL 307 + + CPE + +L E+RP + L Sbjct: 224 MTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYL 270 >4K33-A nrPDB Length = 325 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 113/290 (38%), Gaps = 44/290 (15%) Query: 55 DSTFTVLK-RYQNLKPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAK 106 D + + + R KP+G GA G V A +D++ VA+K L ++ Sbjct: 28 DPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK-DLS 86 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME---- 160 E+ +MK + HKNII+LL T L Y+++E NL + ++ Sbjct: 87 DLVSEMEMMKMIGKHKNIINLLGACTQGGPL------YVLVEYAAKGNLREFLRARRPPG 140 Query: 161 --------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 L + + YQ+ G+++L S IHRDL N++V D +KI Sbjct: 141 LDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 200 Query: 207 DFGLARTAGTSFMMTPYVVTR---YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKIL 262 DFGLAR R + APE + Y D+WS G ++ E+ Sbjct: 201 DFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 260 Query: 263 FPGRDYIDQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 +PG + + + E P + ++ RP + L Sbjct: 261 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 310 >3QA8-A nrPDB Length = 676 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 56/209 (26%), Positives = 90/209 (43%), Gaps = 10/209 (4%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ + +G+G G V VAIK+ + + +R E+ +MK +NH N+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKN-RERWCLEIQIMKKLNHPNV 74 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD------HERMSYLLYQMLCGI 177 +S V + L L ME + + + + + LL + + Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 178 KHLHSAGIIHRDLKPSNIVVK---SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV 234 ++LH IIHRDLKP NIV++ KI+D G A+ + T +V T Y APE+ Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL 194 Query: 235 ILGMGYKENVDIWSVGCIMGEMVRHKILF 263 + Y VD WS G + E + F Sbjct: 195 LEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >2VWV-A nrPDB Length = 302 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 59/262 (22%), Positives = 101/262 (38%), Gaps = 26/262 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + + IG+G G VC + VAIK L + + + E +M H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-TERQRREFLSEASIMGQFEHP 77 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN----LCQVIQMELDHERMSYLLYQMLCGI 177 NII L V T V ++ E M+ ++ + ++ +L + G+ Sbjct: 78 NIIRLEGVVT------NSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 131 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV------VTRYYRA 231 ++L +HRDL NI+V S+ K+ DFGL+R + + + A Sbjct: 132 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTA 191 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEF 286 PE I + D WS G +M E++ + + D N + + P CP Sbjct: 192 PEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTS 251 Query: 287 MKKLQPTVRNYVEN-RPKYAGL 307 + +L N RP++ + Sbjct: 252 LHQLMLDCWQKDRNARPRFPQV 273 >5X02-A nrPDB Length = 347 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 123/313 (39%), Gaps = 54/313 (17%) Query: 43 KVDNQFYSVEVGDSTFTVLKRY-----QNLKPIGSGAQGIVCAAYDAVLDR-----NVAI 92 DN+++ V+ + + + + + K +GSGA G V A + + VA+ Sbjct: 24 SSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAV 83 Query: 93 KKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-D 150 K L + + + + EL +M + +H+NI++LL T +YL+ E Sbjct: 84 KML-KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGP------IYLIFEYCCY 136 Query: 151 ANLCQVIQME-------------------------LDHERMSYLLYQMLCGIKHLHSAGI 185 +L ++ + L E + YQ+ G++ L Sbjct: 137 GDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSC 196 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR---YYRAPEVILGMGYKE 242 +HRDL N++V +KI DFGLAR + R + APE + Y Sbjct: 197 VHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTI 256 Query: 243 NVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE---QLGTPCP--EFMKKLQPTVRN 296 D+WS G ++ E+ +PG + K+I+ ++ P E + + + Sbjct: 257 KSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWA 316 Query: 297 YV-ENRPKYAGLT 308 + RP + LT Sbjct: 317 FDSRKRPSFPNLT 329 >5EG3-A nrPDB Length = 334 Score = 204 bits (519), Expect = 7e-53, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 112/284 (39%), Gaps = 32/284 (11%) Query: 55 DSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLDRN-------VAIKKLSRPFQNQTHAK 106 D + + KP+G GA G V A +D++ VA+K L + + Sbjct: 27 DPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLS 85 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLE---EFQDVYLVMELMDA----------N 152 E+ +MK + HKNII+LL T L + + E + A + Sbjct: 86 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPD 145 Query: 153 LCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 + +V + ++ + + YQ+ G+++L S IHRDL N++V + +KI DFGLAR Sbjct: 146 INRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLAR 205 Query: 213 TAGTSFMMTPYVVTR---YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDY 268 R + APE + Y D+WS G +M E+ +PG Sbjct: 206 DINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 265 Query: 269 IDQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 + + + E P E ++ RP + L Sbjct: 266 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 309 >4XCU-A nrPDB Length = 300 Score = 204 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 71/281 (25%), Positives = 112/281 (39%), Gaps = 35/281 (12%) Query: 55 DSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLD-------RNVAIKKLSRPFQNQTHAK 106 D + R KP+G G G V A +D VA+K L + + Sbjct: 9 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLA 67 Query: 107 RAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME---- 160 E+ +MK + HKNII+LL V T + L Y+++E NL + ++ Sbjct: 68 DLVSEMEVMKLIGRHKNIINLLGVCTQEGPL------YVIVECAAKGNLREFLRARRPPG 121 Query: 161 -----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR--- 212 L + YQ+ G+++L S IHRDL N++V D +KI DFGLAR Sbjct: 122 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 181 Query: 213 TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQ 271 + + + APE + Y D+WS G ++ E+ +PG + Sbjct: 182 HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEEL 241 Query: 272 WNKVIEQLGTP----CPEFMKKLQPTVRN-YVENRPKYAGL 307 ++ + E CP + L + RP + L Sbjct: 242 FSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQL 282 >5U6B-A nrPDB Length = 307 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 104/281 (37%), Gaps = 20/281 (7%) Query: 66 NLKPIGSGAQGIVCAAYDAVLD--RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 K +G G G V D VA+K + ++ + E V MK +H N+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME--------LDHERMSYLLYQML 174 + L+ V E F +++ M +L + L + + + + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYRA 231 G+++L + IHRDL N ++ + ++ + DFGL++ + + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE----QLGTPCPEF 286 E + Y D+WS G M E+ + +PG + + ++ + + + C + Sbjct: 207 IESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDG 266 Query: 287 MKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLFPADSEHNK 326 + L ++RP + L P E ++ Sbjct: 267 LYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDE 307 >4OTD-A nrPDB Length = 341 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 65/343 (18%), Positives = 127/343 (37%), Gaps = 62/343 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCV- 118 L+ ++ L +G G G V + AIK L + + + E ++ V Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 119 --NHKNIISLLNVFTPQKTLEEFQDVYLVMEL-MDANLCQVIQME-LDHERMSYLLYQML 174 H +++L F + V VME +L I + R + ++ Sbjct: 71 SAGHPFLVNLFGCFQTP------EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVV 124 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPE 233 G++ LH I++RDLK N+++ ++ +KI DFGL + G + + T + APE Sbjct: 125 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y VD W +G ++ EM+ + FPG D + ++ ++ Sbjct: 185 VLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN---------------- 228 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI----- 348 + + + +++A ++ ++L +P +R+ Sbjct: 229 --------------------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSER 262 Query: 349 SVDDALQHPYINV--WYDPAEVEAPPPQIYDKQLDEREHTIEE 389 +D + P+ W PPP + +E Sbjct: 263 DAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDE 305 >4AT3-A nrPDB Length = 299 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 56/260 (21%), Positives = 99/260 (38%), Gaps = 37/260 (14%) Query: 66 NLKPIGSGAQGIVCAAYDA-----VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + +G GA G V A VA+K L N K +RE L+ + H Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN--ARKDFHREAELLTNLQH 74 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ---------------MELDHE 164 ++I+ V L +V E M +L + ++ EL Sbjct: 75 EHIVKFYGVCVEGDPLI------MVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQS 128 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV 224 +M ++ Q+ G+ +L S +HRDL N +V + +KI DFG++R ++ Sbjct: 129 QMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG 188 Query: 225 VT---RYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE--- 277 T + PE I+ + D+WS+G ++ E+ K + + + + Sbjct: 189 HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV 248 Query: 278 -QLGTPCPEFMKKLQPTVRN 296 Q CP+ + +L Sbjct: 249 LQRPRTCPQEVYELMLGCWQ 268 >3KUL-B nrPDB Length = 325 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 105/262 (40%), Gaps = 24/262 (9%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 R K IGSG G VC V + VAIK L + + + E +M + Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQFD 108 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN----LCQVIQMELDHERMSYLLYQMLC 175 H NII L V T + +V E M+ + + ++ +L + Sbjct: 109 HPNIIRLEGVVTRGRLA------MIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGA 162 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRA 231 G+++L G +HRDL N++V S+ K+ DFGL+R + T + + A Sbjct: 163 GMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTA 222 Query: 232 PEVILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIEQLGTP----CPEF 286 PE I + D+WS G +M E + + + D + V E P CP Sbjct: 223 PEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHA 282 Query: 287 MKKLQPTVRNYVE-NRPKYAGL 307 + +L + RP+++ + Sbjct: 283 LHQLMLDCWHKDRAQRPRFSQI 304 >5SYS-A nrPDB Length = 286 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 102/252 (40%), Gaps = 24/252 (9%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G R VAIK L + + +E +MK + H+ ++ L Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 129 VFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSA 183 V + + +Y+V E M +L ++ E L ++ + Q+ G+ ++ Sbjct: 81 VVSEEP-------IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 133 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV--TRYYRAPEVILGMGYK 241 +HRDL+ +NI+V + K+ DFGLAR + + APE L + Sbjct: 134 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 193 Query: 242 ENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE-----FMKKLQPTVR 295 D+WS G ++ E+ ++ +PG + ++V PCP + R Sbjct: 194 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 253 Query: 296 NYVENRPKYAGL 307 E RP + L Sbjct: 254 KDPEERPTFEYL 265 >4H1J-A nrPDB Length = 293 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 106/273 (38%), Gaps = 24/273 (8%) Query: 51 VEVGDSTFTVLKRYQNL-KPIGSGAQGIVCAAY---DAVLDRNVAIKKLSRPFQNQTHAK 106 V G + + + L + +G G G V NVA+K + + + Sbjct: 12 VPRGSPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDC-TLDNKE 70 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD----ANLCQVIQMELD 162 + E V+MK ++H +I+ L+ + + T +++MEL + + + L Sbjct: 71 KFMSEAVIMKNLDHPHIVKLIGIIEEEPT-------WIIMELYPYGELGHYLERNKNSLK 123 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP 222 + Q+ + +L S +HRD+ NI+V S +K+ DFGL+R Sbjct: 124 VLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKA 183 Query: 223 YVV--TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQL 279 V + +PE I + D+W M E++ K F + D + + Sbjct: 184 SVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGD 243 Query: 280 GTP----CPEFMKKLQPTVRNY-VENRPKYAGL 307 P CP + L +Y +RP++ L Sbjct: 244 RLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTEL 276 >4XLV-A nrPDB Length = 328 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 121/311 (38%), Gaps = 36/311 (11%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCA--AYDAVLDR---NVAIKKLSRPFQNQTH 104 SV V D ++ L+ +G G+ G+V A D + VA+K ++ + Sbjct: 27 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRE 85 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDH 163 E +MK +++ LL V + + +VMELM +L ++ Sbjct: 86 RIEFLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKSYLRSLRPE 139 Query: 164 ------------ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA 211 + M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ Sbjct: 140 AENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMT 199 Query: 212 RTA-GTSFMMTPYVV--TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRD 267 R T + + APE + + + D+WS G ++ E+ + + G Sbjct: 200 RDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLS 259 Query: 268 YIDQWNKVIE----QLGTPCPEFMKKLQPTVRNYVEN-RPKYAGLTFPKLFPDSLFPADS 322 V++ CPE + L + N RP + L L D L P+ Sbjct: 260 NEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTF--LEIVNLLKDDLHPSFP 317 Query: 323 EHNKLKASQAR 333 E + + + + Sbjct: 318 EVSFFHSEENK 328 >6BXI-A nrPDB Length = 333 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 64/323 (19%), Positives = 112/323 (34%), Gaps = 56/323 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 L+ +++LK IG GA G V A+K L + + E ++ + Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQMLCG 176 ++ + F + ++YL+ME + + M+ L E + + + + Sbjct: 65 SLWVVKMFYSFQDK------LNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLA 118 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY------------- 223 I +H G IHRD+KP N+++ S +K+ DFGL + Y Sbjct: 119 IDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTF 178 Query: 224 -----------------------VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK 260 V T Y APEV + GY + D WS+G IM EM+ Sbjct: 179 QNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGY 238 Query: 261 ILFPGRDYIDQWNKVI---EQLGTPCPEFMKKLQPTV-------RNYVENRPKYAGLTFP 310 F + + KV+ E L P + + + + P + Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKSN 298 Query: 311 KLFPDSLFPADSEHNKLKASQAR 333 F + E + + + Sbjct: 299 SFFEGVDWEHIRERPAAISIEIK 321 >4PDO-A nrPDB Length = 299 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 63/261 (24%), Positives = 105/261 (40%), Gaps = 25/261 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVL-DRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 K IG+G G V + VAIK L + + E +M +H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQRVDFLGEAGIMGQFSH 95 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE----RMSYLLYQMLCG 176 NII L V + ++ + ++ E M+ E D E ++ +L + G Sbjct: 96 HNIIRLEGVISK------YKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 149 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAP 232 +K+L + +HRDL NI+V S+ K+ DFGL+R + + + + AP Sbjct: 150 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 209 Query: 233 EVILGMGYKENVDIWSVGCIMGE-MVRHKILFPGRDYIDQWNKVIE--QLGTP--CPEFM 287 E I + D+WS G +M E M + + + + + +L TP CP + Sbjct: 210 EAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAI 269 Query: 288 KKLQPTVRNYVE-NRPKYAGL 307 +L RPK+A + Sbjct: 270 YQLMMQCWQQERARRPKFADI 290 >5HIE-A nrPDB Length = 302 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 117/276 (42%), Gaps = 41/276 (14%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 E+ D TV +R IGSG+ G V VA+K L + E Sbjct: 32 EIPDGQITVGQR------IGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNE 77 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN----LCQVIQMELDHERMS 167 + +++ H NI+ + T + + +V + + + +I+ + + ++ Sbjct: 78 VGVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHIIETKFEMIKLI 130 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT---SFMMTPYV 224 + Q G+ +LH+ IIHRDLK +NI + D T+KI DFGLA S Sbjct: 131 DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS 190 Query: 225 VTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ---------W 272 + + APEVI Y D+++ G ++ E++ ++ + + DQ Sbjct: 191 GSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYL 250 Query: 273 NKVIEQLGTPCPEFMKKLQPTV-RNYVENRPKYAGL 307 + + ++ + CP+ MK+L + + RP + + Sbjct: 251 SPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 286 >1TKI-A nrPDB Length = 321 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 119/309 (38%), Gaps = 53/309 (17%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 + ++Y + +G G GIV + + K + +Q K+ E+ ++ Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIA 58 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ---MELDHERMSYLLYQML 174 H+NI+ L F E +++ ++ E + ++ + I EL+ + ++Q+ Sbjct: 59 RHRNILHLHESF------ESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVC 112 Query: 175 CGIKHLHSAGIIHRDLKPSNIVV--KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAP 232 ++ LHS I H D++P NI+ + T+KI++FG AR Y AP Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAP 172 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 EV D+WS+G ++ ++ F ++ Sbjct: 173 EVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMN--------------- 217 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 + + D E K + +A D + ++LV + R++ + Sbjct: 218 -----------------------AEYTFDEEAFKEISIEAMDFVDRLLVKERKSRMTASE 254 Query: 353 ALQHPYINV 361 ALQHP++ Sbjct: 255 ALQHPWLKQ 263 >3QUP-A nrPDB Length = 323 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 104/270 (38%), Gaps = 21/270 (7%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLD---RNVAIKKLSRPFQNQTHAKRAYRELVLMKCV 118 +++ + +G G G V A D VA+K L + + RE MK Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---------MELDHERMSYL 169 +H ++ L+ V + +++ M L + + Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR-- 227 + + CG+++L S IHRDL N ++ D T+ + DFGL+R + ++ Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 228 -YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVI--EQLGTP- 282 + A E + Y + D+W+ G M E++ + + G + + +N +I +L P Sbjct: 203 VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPP 262 Query: 283 -CPEFMKKLQPTVRN-YVENRPKYAGLTFP 310 C E + L + + RP + L Sbjct: 263 ECMEEVYDLMYQCWSADPKQRPSFTCLRME 292 >3ORP-A nrPDB Length = 311 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 120/295 (40%), Gaps = 18/295 (6%) Query: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYRELVLMKC 117 + RY+ + +G G V A D R+VA+K L ++ + R RE Sbjct: 9 HLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQML 174 +NH I+++ + T + Y+VME +D L ++ E + +R ++ Sbjct: 69 LNHPAIVAVYD--TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADAC 126 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY----VVTRYYR 230 + H GIIHRD+KP+NI++ + +K++DFG+AR S + T Y Sbjct: 127 QALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 +PE G D++S+GC++ E++ + F G + + + + P + L Sbjct: 187 SPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGL 246 Query: 291 Q--------PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 + ENR + A L L ++ LLS Sbjct: 247 SADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLS 301 >2HK5-A nrPDB Length = 270 Score = 201 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 106/268 (39%), Gaps = 26/268 (9%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAA-YDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 D+ + + K +G+G G V A Y+ VA+K + + E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPG---SMSVEAFLAEA 61 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMEL----DHERMS 167 +MK + H ++ L V T + +Y++ E M +L ++ + ++ Sbjct: 62 NVMKTLQHDKLVKLHAVVTKEP-------IYIITEFMAKGSLLDFLKSDEGSKQPLPKLI 114 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVV 225 Q+ G+ + IHRDL+ +NI+V + KI DFGLAR + Sbjct: 115 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKF 174 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP-- 282 + APE I + D+WS G ++ E+V +I +PG + + P Sbjct: 175 PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRP 234 Query: 283 --CPEFMKKLQPTVR-NYVENRPKYAGL 307 CPE + + N E RP + + Sbjct: 235 ENCPEELYNIMMRCWKNRPEERPTFEYI 262 >4EQM-A nrPDB Length = 294 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 78/287 (27%), Positives = 134/287 (46%), Gaps = 13/287 (4%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK-KLSRPFQNQTHAKRAYRELVLMKCV 118 + +RY+ + +G G V A D +L+ VAIK P + + KR RE+ + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLC 175 +H+NI+S+++V EE YLVME ++ L + I+ L + Q+L Sbjct: 69 SHQNIVSMIDV------DEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP--YVVTRYYRAPE 233 GIKH H I+HRD+KP NI++ S+ TLKI DFG+A+ + + + T Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ-WNKVIEQLGTPCPEFMKKLQP 292 G E DI+S+G ++ EM+ + F G + + + + + K + Sbjct: 183 QAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQ 242 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 ++ N + + K + S ++ +A++ L KM Sbjct: 243 SLSNVILRATEKDKANRYKTIQEMKDDLSSVLHENRANEDVYELDKM 289 >4PWN-A nrPDB Length = 274 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 112/299 (37%), Gaps = 48/299 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 IG G+ V D VA +L ++ +R E ++K + H NI+ + Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERM---SYLLYQMLCGIKHLHSAG- 184 + + T++ + + LV ELM + + ++ Q+L G++ LH+ Sbjct: 77 SW--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 185 -IIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 IIHRDLK NI + ++KI D GLA + + T + APE + Y E Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE-MYEEKYDE 193 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 +VD+++ G M EM + + Q + + P Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKP-------------------- 233 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 + +K+ + ++++ + + +R S+ D L H + Sbjct: 234 -------------------ASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5O2B-A nrPDB Length = 285 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 114/299 (38%), Gaps = 49/299 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G GA V D VA +L + +R E ++K + H NI+ + Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL---DHERMSYLLYQMLCGIKHLHSAG- 184 + + L+ + + LV ELM + + + + Q+L G++ LH+ Sbjct: 83 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 185 -IIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 IIHRDLK NI + ++KI D GLA TSF + T + APE + Y E Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPE-MYEEHYDE 198 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 +VD+++ G M EM + + Q + + P Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP-------------------- 238 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 + NK+ + ++++ + + ++R+S+ D L H + Sbjct: 239 -------------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >4E20-A nrPDB Length = 290 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 110/283 (38%), Gaps = 35/283 (12%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCA-AYDA---VLDRNVAIKKLSRPFQNQTHAKRAYR 110 D T + + ++ +G G G V YD VA+K L Q R Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQL-RSGWQR 59 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-LDHERMSY 168 E+ +++ + H++I+ Q + V LVME + +L + + ++ Sbjct: 60 EIEILRTLYHEHIVKYKGCCEDQGE----KSVQLVMEYVPLGSLRDYLPRHCVGLAQLLL 115 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV---- 224 Q+ G+ +LH+ IHR L N+++ +D +KI DFGLA+ Sbjct: 116 FAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGD 175 Query: 225 VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRH-------KILF-------PGRDYID 270 ++ APE + + D+WS G + E++ + F G+ + Sbjct: 176 SPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVL 235 Query: 271 QWNKVI---EQLGTP--CPEFMKKLQPTVRNYVEN-RPKYAGL 307 + +++ E+L P CP + L + RP + L Sbjct: 236 RLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >2W1I-A nrPDB Length = 326 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 72/321 (22%), Positives = 128/321 (39%), Gaps = 49/321 (15%) Query: 42 SKVDNQFYSVEVG------DSTFTVLKRYQNLKPIGSGAQGIVCAAY----DAVLDRNVA 91 +N ++ +G D T + + L+ +G G G V VA Sbjct: 15 PTTENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA 74 Query: 92 IKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD- 150 +KKL + H + RE+ ++K + H NI+ V +++ L+ME + Sbjct: 75 VKKLQH--STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAG----RRNLKLIMEYLPY 128 Query: 151 ANLCQVIQM---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILD 207 +L +Q +DH ++ Q+ G+++L + IHRDL NI+V+++ +KI D Sbjct: 129 GSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGD 188 Query: 208 FGLARTAGTSFMMT----PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF 263 FGL + P ++ APE + + D+WS G ++ E+ + Sbjct: 189 FGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY---- 244 Query: 264 PGRDYIDQWNKVIEQLGTPCPEFMKKL------QPTVRNYVENRPKYAGLTFPKLFPDSL 317 IE+ +P EFM+ + Q V + +E L P PD + Sbjct: 245 ------------IEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEI 292 Query: 318 F---PADSEHNKLKASQARDL 335 + +N + RDL Sbjct: 293 YMIMTECWNNNVNQRPSFRDL 313 >6GQK-A nrPDB Length = 328 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 115/312 (36%), Gaps = 48/312 (15%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDR-- 88 +Y+ + E R K +G+GA G V A L + Sbjct: 16 ESNGNNYSYIDPTQLPYDHKWEFP------RNRLSFGKTLGAGAFGKVVEATAQGLIKSD 69 Query: 89 ---NVAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYL 144 VA+K L +P + T + EL ++ + NH+NI++LL T + Sbjct: 70 AAMTVAVKML-KPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPT------LV 122 Query: 145 VMELM-DANLCQVIQMELDH------------------ERMSYLLYQMLCGIKHLHSAGI 185 + E +L ++ + D E + YQ+ G+ L S Sbjct: 123 ITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNC 182 Query: 186 IHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR---YYRAPEVILGMGYKE 242 IHRDL NI++ KI DFGLAR R + APE I Y Sbjct: 183 IHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTF 242 Query: 243 NVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQPTVRN 296 D+WS G + E+ +PG ++ K+I+ ++ +P P M + T + Sbjct: 243 ESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWD 302 Query: 297 -YVENRPKYAGL 307 + RP + + Sbjct: 303 ADPDKRPTFKQI 314 >3QGY-A nrPDB Length = 286 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 59/256 (23%), Positives = 103/256 (40%), Gaps = 24/256 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 ++ IGSG G+V Y D+ VAIK + ++ E +M ++H ++ Sbjct: 30 TFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSE---DDFIEEAEVMMKLSHPKLV 85 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME---LDHERMSYLLYQMLCGIKHL 180 L V Q + LV E M+ L ++ + E + + + G+ +L Sbjct: 86 QLYGVCLEQAP------ICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYL 139 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPEVILG 237 A +IHRDL N +V + +K+ DFG+ R T T++ + +PEV Sbjct: 140 EEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVFSF 198 Query: 238 MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEF-----MKKLQ 291 Y D+WS G +M E+ KI + R + + P + + Sbjct: 199 SRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMN 258 Query: 292 PTVRNYVENRPKYAGL 307 + E+RP ++ L Sbjct: 259 HCWKERPEDRPAFSRL 274 >2OGV-A nrPDB Length = 317 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 119/304 (39%), Gaps = 26/304 (8%) Query: 27 QVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVL 86 QV I + S + +D + + Q K +G+GA G V A L Sbjct: 5 QVRWKIIESYEGNSYTFIDPT--QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL 62 Query: 87 DRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQ 140 + VA+K L + + + EL +M + H+NI++LL T + Sbjct: 63 GKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVIT 121 Query: 141 DVYLVMELM-------DANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193 + +L+ +A+L + L+ + + Q+ G+ L S IHRD+ Sbjct: 122 EYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAAR 181 Query: 194 NIVVKSDCTLKILDFGLARTAGTSFMM---TPYVVTRYYRAPEVILGMGYKENVDIWSVG 250 N+++ + KI DFGLAR + + APE I Y D+WS G Sbjct: 182 NVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG 241 Query: 251 CIMGEMVR-HKILFPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQPTVRN-YVENRPK 303 ++ E+ +PG ++ K+++ Q+ P P+ + + +RP Sbjct: 242 ILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 301 Query: 304 YAGL 307 + + Sbjct: 302 FQQI 305 >4CRS-A nrPDB Length = 341 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 66/343 (19%), Positives = 132/343 (38%), Gaps = 62/343 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR-PFQNQTHAKRAYRELVLMKCVN 119 L+ ++ + G G V A + AIK L + + E + + VN Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 120 ---HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME-LDHERMSYLLYQML 174 H +++L F + + V VME +L I + R + ++ Sbjct: 71 SVRHPFLVNLFACFQTK------EHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVV 124 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-AGTSFMMTPYVVTRYYRAPE 233 G+++LH I++RDLK N+++ ++ +KI DFGL + G + + T + APE Sbjct: 125 LGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPE 184 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 V+ Y VD W +G ++ EM+ + FPG D + ++ ++ Sbjct: 185 VLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN---------------- 228 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI----- 348 + + + +++A ++ ++L +P +R+ Sbjct: 229 --------------------------DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEK 262 Query: 349 SVDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 +D +HP+ W + + PP I + E ++ Sbjct: 263 DAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDD 305 >2VD5-A nrPDB Length = 412 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 61/336 (18%), Positives = 115/336 (34%), Gaps = 61/336 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELV-LMKCVN 119 ++ LK IG GA V + A+K +++ + +RE ++ + Sbjct: 60 RDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 119 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMEL-MDANLCQVIQM---ELDHERMSYLLYQMLC 175 + I L F + +YLVME + +L ++ + E + L +++ Sbjct: 120 RRWITQLHFAFQDE------NYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 173 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY--VVTRYYRAPE 233 I +H G +HRD+KP NI++ +++ DFG + V T Y +PE Sbjct: 174 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 233 Query: 234 VIL-------GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286 ++ Y D W++G EM + F + + K++ Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 293 Query: 287 MKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK 346 + + P +ARD + ++L P Sbjct: 294 VDEGVP-------------------------------------EEARDFIQRLLCP-PET 315 Query: 347 RI---SVDDALQHPYINVWYDPAEVEAPPPQIYDKQ 379 R+ D HP+ ++ PP D + Sbjct: 316 RLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFE 351 >5O2C-A nrPDB Length = 380 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 114/299 (38%), Gaps = 49/299 (16%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G GA V D VA +L + +R E ++K + H NI+ + Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 129 VFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL---DHERMSYLLYQMLCGIKHLHSAG- 184 + + L+ + + LV ELM + + + + Q+L G++ LH+ Sbjct: 92 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 185 -IIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE 242 IIHRDLK NI + ++KI D GLA TSF + T + APE + Y E Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPE-MYEEHYDE 207 Query: 243 NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRP 302 +VD+++ G M EM + + Q + + P Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP-------------------- 247 Query: 303 KYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 + NK+ + ++++ + + ++R+S+ D L H + Sbjct: 248 -------------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >3V5Q-A nrPDB Length = 297 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 97/263 (36%), Gaps = 40/263 (15%) Query: 66 NLKPIGSGAQGIVCAAYD-----AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + +G GA G V A VA+K L P K RE L+ + H Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP--TLAARKDFQREAELLTNLQH 76 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM------------------EL 161 ++I+ V L +V E M +L + ++ EL Sbjct: 77 EHIVKFYGVCGDGDPLI------MVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGEL 130 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT 221 +M ++ Q+ G+ +L S +HRDL N +V ++ +KI DFG++R ++ Sbjct: 131 GLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR 190 Query: 222 PYVVT---RYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE 277 T + PE I+ + D+WS G I+ E+ K + + + + Sbjct: 191 VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQ 250 Query: 278 ----QLGTPCPEFMKKLQPTVRN 296 + CP+ + + Sbjct: 251 GRVLERPRVCPKEVYDVMLGCWQ 273 >5B2L-A nrPDB Length = 324 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 69/333 (20%), Positives = 120/333 (36%), Gaps = 63/333 (18%) Query: 44 VDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQT 103 + Q Y E+ D +NL +GSG G V +A+K++ R N+ Sbjct: 7 IGGQRYQAEINDL--------ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GNKE 57 Query: 104 HAKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN---LCQVIQM 159 KR +L V++K + I+ F DV++ MELM + L + +Q Sbjct: 58 ENKRILMDLDVVLKSHDCPYIVQCFGTFITN------TDVFIAMELMGTSAEKLKKRMQG 111 Query: 160 ELDHERMSYLLYQMLCGIKHL-HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 + + + ++ + +L G+IHRD+KPSNI++ +K+ DFG++ S Sbjct: 112 PIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSK 171 Query: 219 MMTPYVVTRYYRAPEVI-----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 T Y APE I Y D+WS+G + E+ + + Sbjct: 172 AKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPY---------- 221 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQAR 333 C + L ++ P + G + + Sbjct: 222 -------KNCKTDFEVLTKVLQEEPPLLPGHMGF---------------------SGDFQ 253 Query: 334 DLLSKMLVIDPAKRISVDDALQHPYINVWYDPA 366 + L D KR + L+H +I + Sbjct: 254 SFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLE 286 >6FEX-A nrPDB Length = 321 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 107/294 (36%), Gaps = 56/294 (19%) Query: 63 RYQNLKPIGSGAQGIVCAAY--------------DAVLDRN--VAIKKLSRPFQNQTHAK 106 R + + +G G G V + VA+K L RP + Sbjct: 17 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNARN 75 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----- 160 +E+ +M + NII LL V L ++ + M+ +L Q + Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPL------CMITDYMENGDLNQFLSAHQLEDK 129 Query: 161 ----------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL 210 + + + ++ Q+ G+++L + +HRDL N +V + T+KI DFG+ Sbjct: 130 AAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 189 Query: 211 ARTAGTSFMMTPY---VVTRYYRAPEVILGMGYKENVDIWSVGCIMGE--MVRHKILF-- 263 +R V+ + A E IL + D+W+ G + E M+ F Sbjct: 190 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ 249 Query: 264 ---------PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR-NYVENRPKYAGL 307 G + DQ +V CP+ + +L E RP ++ L Sbjct: 250 LTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 303 >4HZS-A nrPDB Length = 341 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 26/265 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAA-YDAVLDRNV--AIKKLSRPFQNQTHA-KRAYRELVLMKC 117 K + L+ +G G+ G+V +DA + V A+K L +Q A RE+ M Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH---ERMSYLLYQM 173 ++H+N+I L V +V EL +L ++ H +S Q+ Sbjct: 72 LDHRNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV 124 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYY 229 G+ +L S IHRDL N+++ + +KI DFGL R + M V + Sbjct: 125 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 184 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKV---IEQLGTP--C 283 APE + + D W G + EM + + G + +K+ E+L P C Sbjct: 185 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 244 Query: 284 PEFMKKLQPTVRNY-VENRPKYAGL 307 P+ + + + E+RP + L Sbjct: 245 PQDIYNVMVQCWAHKPEDRPTFVAL 269 >3BBT-B nrPDB Length = 328 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 114/298 (38%), Gaps = 30/298 (10%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDR----NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + +K +GSGA G V VAIK L+ + + + E ++M ++H Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASMDH 76 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ERMSYLLYQMLCG 176 +++ LL V + LV +LM L + + D+ + + Q+ G Sbjct: 77 PHLVRLLGVCLSPT-------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKG 129 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYRAPE 233 + +L ++HRDL N++VKS +KI DFGLAR + A E Sbjct: 130 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 189 Query: 234 VILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE----FMK 288 I + D+WS G + E++ + G + + + + P P + Sbjct: 190 CIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVY 249 Query: 289 KLQPTVRNYV-ENRPKYAGL--TFPKLFPD---SLFPADSEHNKLKASQARDLLSKML 340 + ++RPK+ L F ++ D L + KL + +L Sbjct: 250 MVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLL 307 >4LFI-A nrPDB Length = 374 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 68/363 (18%), Positives = 144/363 (39%), Gaps = 46/363 (12%) Query: 36 HYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAI--- 92 + N++K + + + T K Y+ +G G V + I Sbjct: 14 YTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML 73 Query: 93 ---------------------KKLSRPFQNQTHAKRAYRELVLMKCVN----------HK 121 K Q ++ ++K + H Sbjct: 74 KPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHA 133 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLH 181 NII L ++ + LV E +D +++ +L + + ++++L + + H Sbjct: 134 NIIHLFDIIKDPISKTPA----LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCH 189 Query: 182 SAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG- 239 S GI+HRD+KP N+++ + L+++D+GLA + V +R+++ PE+++ Sbjct: 190 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRM 249 Query: 240 YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 Y ++D+WS G ++ M+ + + F G DQ K+++ LGT E + ++ + Sbjct: 250 YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFE-----KYLLKYEI 304 Query: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 ++ + P F D + + DL+ +L D +R++ +A+ HP+ Sbjct: 305 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 364 Query: 359 INV 361 Sbjct: 365 FAP 367 >1U54-B nrPDB Length = 291 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 26/265 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAA-YDAVLDRNV--AIKKLSRPFQNQTHA-KRAYRELVLMKC 117 K + L+ +G G+ G+V +DA + V A+K L +Q A RE+ M Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH---ERMSYLLYQM 173 ++H+N+I L V +V EL +L ++ H +S Q+ Sbjct: 78 LDHRNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQV 130 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYY 229 G+ +L S IHRDL N+++ + +KI DFGL R + M V + Sbjct: 131 AEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAW 190 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKV---IEQLGTP--C 283 APE + + D W G + EM + + G + +K+ E+L P C Sbjct: 191 CAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDC 250 Query: 284 PEFMKKLQPTVRNY-VENRPKYAGL 307 P+ + + + E+RP + L Sbjct: 251 PQDIYNVMVQCWAHKPEDRPTFVAL 275 >4XUF-A nrPDB Length = 297 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 113/290 (38%), Gaps = 49/290 (16%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDR-----NVAIKKLSRPFQNQTHAKRAYRELVLM 115 + + K +GSGA G V A + + VA+K L + + + + EL +M Sbjct: 8 RENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMSELKMM 66 Query: 116 KCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME------------- 160 + +H+NI++LL T +YL+ E +L ++ + Sbjct: 67 TQLGSHENIVNLLGACTLSGP------IYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 120 Query: 161 ------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 L E + YQ+ G++ L +HRDL N++V +KI DF Sbjct: 121 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDF 180 Query: 209 GLARTAGTSFMMTPYVVTR---YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFP 264 GLAR + R + APE + Y D+WS G ++ E+ +P Sbjct: 181 GLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYP 240 Query: 265 GRDYIDQWNKVIE---QLGTPCP--EFMKKLQPTVRNYV-ENRPKYAGLT 308 G + K+I+ ++ P E + + + + RP + LT Sbjct: 241 GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 290 >1FVR-A nrPDB Length = 327 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 61/274 (22%), Positives = 104/274 (37%), Gaps = 35/274 (12%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLD--RNVAIKKLSRPFQNQTHAKRAYRELVLM-KCV 118 + IG G G V A + AIK++ + + ++ + EL ++ K Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLG 83 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----------------- 160 +H NII+LL E +YL +E NL ++ Sbjct: 84 HHPNIINLLGAC------EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 161 -LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 219 L +++ + + G+ +L IHRDL NI+V + KI DFGL+R Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVK 197 Query: 220 MTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQ 278 T + + A E + Y N D+WS G ++ E+V + G + + K+ + Sbjct: 198 KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG 257 Query: 279 LGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 P E ++ R RP +A + Sbjct: 258 YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI 291 >3OMV-A nrPDB Length = 307 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 125/298 (41%), Gaps = 39/298 (13%) Query: 31 SYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNV 90 K+ + + D+ +Y E+ S + R IGSG+ G V V Sbjct: 12 GTQEKNKIRPRGQRDSSYY-WEIEASEVMLSTR------IGSGSFGTVYKGKWHGD---V 61 Query: 91 AIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD 150 A+K L + E+ +++ H NI+ + T ++ +V + + Sbjct: 62 AVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKD-------NLAIVTQWCE 114 Query: 151 AN----LCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 + V + + ++ + Q G+ +LH+ IIHRD+K +NI + T+KI Sbjct: 115 GSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIG 174 Query: 207 DFGLA----RTAGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRH 259 DFGLA R +G+ + P + + APEVI + D++S G ++ E++ Sbjct: 175 DFGLATVKSRWSGSQQVEQP-TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTG 233 Query: 260 KILFPGRDYIDQW---------NKVIEQLGTPCPEFMKKL-QPTVRNYVENRPKYAGL 307 ++ + + DQ + + +L CP+ MK+L V+ E RP + + Sbjct: 234 ELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI 291 >3IO7-A nrPDB Length = 313 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 120/295 (40%), Gaps = 43/295 (14%) Query: 62 KRYQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 + + L+ +G G G V VA+KKL + H + RE+ ++K Sbjct: 28 RHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFEREIEILKS 85 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM---ELDHERMSYLLYQM 173 + H NI+ V +++ L+ME + +L +Q +DH ++ Q+ Sbjct: 86 LQHDNIVKYKGVCYSAG----RRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 141 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT----PYVVTRYY 229 G+++L + IHRDL NI+V+++ +KI DFGL + P ++ Sbjct: 142 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 201 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APE + + D+WS G ++ E+ + IE+ +P EFM+ Sbjct: 202 YAPESLTESKFSVASDVWSFGVVLYELFTY----------------IEKSKSPPAEFMRM 245 Query: 290 L------QPTVRNYVENRPKYAGLTFPKLFPDSLF---PADSEHNKLKASQARDL 335 + Q V + +E L P PD ++ +N + RDL Sbjct: 246 IGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >1BYG-A nrPDB Length = 278 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 57/258 (22%), Positives = 104/258 (40%), Gaps = 24/258 (9%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +K + L+ IG G G V VA+K + N A+ E +M + H Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 73 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 175 N++ LL V +EE +Y+V E M +L ++ L + + + Sbjct: 74 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 128 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +++L +HRDL N++V D K+ DFGL + A ++ + + APE + Sbjct: 129 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEAL 186 Query: 236 LGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMKKL 290 + D+WS G ++ E+ ++ +P D +V + CP + ++ Sbjct: 187 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEV 246 Query: 291 QPTVRNYVEN-RPKYAGL 307 + RP + L Sbjct: 247 MKNCWHLDAAMRPSFLQL 264 >1AD5-A nrPDB Length = 438 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 105/266 (39%), Gaps = 32/266 (12%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAA-YDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 D+ + + K +G+G G V A Y+ VA+K + + E Sbjct: 174 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPG---SMSVEAFLAEA 228 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMEL----DHERMS 167 +MK + H ++ L V T + +Y++ E M +L ++ + ++ Sbjct: 229 NVMKTLQHDKLVKLHAVVTKEP-------IYIITEFMAKGSLLDFLKSDEGSKQPLPKLI 281 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR 227 Q+ G+ + IHRDL+ +NI+V + KI DFGLAR Sbjct: 282 DFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAKFPI 333 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP---- 282 + APE I + D+WS G ++ E+V +I +PG + + P Sbjct: 334 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN 393 Query: 283 CPEFMKKLQPTVR-NYVENRPKYAGL 307 CPE + + N E RP + + Sbjct: 394 CPEELYNIMMRCWKNRPEERPTFEYI 419 >3BEA-A nrPDB Length = 333 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 117/314 (37%), Gaps = 42/314 (13%) Query: 27 QVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVL 86 QV I + S + +D + + Q K +G+GA G V A L Sbjct: 13 QVRWKIIESYEGNSYTFIDPT--QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL 70 Query: 87 DRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQ 140 + VA+K L + + + EL +M + H+NI++LL T Sbjct: 71 GKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP----- 124 Query: 141 DVYLVMELM-DANLCQVIQME----------------LDHERMSYLLYQMLCGIKHLHSA 183 V ++ E +L ++ + L + + Q+ G+ L S Sbjct: 125 -VLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASK 183 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM---TPYVVTRYYRAPEVILGMGY 240 IHRD+ N+++ + KI DFGLAR + + APE I Y Sbjct: 184 NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVY 243 Query: 241 KENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQPTV 294 D+WS G ++ E+ +PG ++ K+++ Q+ P P+ + + Sbjct: 244 TVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQAC 303 Query: 295 RN-YVENRPKYAGL 307 +RP + + Sbjct: 304 WALEPTHRPTFQQI 317 >1LUF-A nrPDB Length = 343 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 98/284 (34%), Gaps = 48/284 (16%) Query: 65 QNLKPIGSGAQGIVCAAYDAVL-----DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 + ++ IG GA G V A L VA+K L A RE LM + Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA-DFQREAALMAEFD 108 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH--------------- 163 + NI+ LL V K + L+ E M +L + ++ H Sbjct: 109 NPNIVKLLGVCAVGKP------MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162 Query: 164 -----------ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 + Q+ G+ +L +HRDL N +V + +KI DFGL+R Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 222 Query: 213 TAGTSFMMT---PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDY 268 ++ + + PE I Y D+W+ G ++ E+ + G + Sbjct: 223 NIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 282 Query: 269 IDQWNKV----IEQLGTPCPEFMKKLQPTVR-NYVENRPKYAGL 307 + V I CP + L +RP + + Sbjct: 283 EEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSI 326 >1K9A-A nrPDB Length = 450 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 57/258 (22%), Positives = 103/258 (39%), Gaps = 24/258 (9%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 +K + L+ IG G G V VA+K + N A+ E +M + H Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME----LDHERMSYLLYQMLC 175 N++ LL V +EE +Y+V E M +L ++ L + + + Sbjct: 246 SNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 235 +++L +HRDL N++V D K+ DFGL + A ++ + + APE + Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ--DTGKLPVKWTAPEAL 358 Query: 236 LGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP----CPEFMKKL 290 + D+WS G ++ E+ ++ +P D +V + CP + + Sbjct: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDV 418 Query: 291 QPTVRNYV-ENRPKYAGL 307 + RP + L Sbjct: 419 MKNCWHLDAATRPTFLQL 436 >3ZBF-A nrPDB Length = 322 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 109/296 (36%), Gaps = 37/296 (12%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAV-----LDR-NVAIKKL 95 +N ++ + + ++ +GSGA G V VA+K L Sbjct: 13 PTTENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTL 72 Query: 96 SRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLC 154 + +Q +E LM NH NI+ L V + Y+++ELM+ +L Sbjct: 73 KKGSTDQ-EKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDLL 125 Query: 155 QVIQM---------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-----KSD 200 ++ L + L + G +L IHRDL N +V S Sbjct: 126 TYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP 185 Query: 201 CTLKILDFGLARTAGTSFMMTPY---VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV 257 +KI DFGLAR + ++ + APE ++ + D+WS G ++ E++ Sbjct: 186 RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEIL 245 Query: 258 R-HKILFPGRDYIDQWNKVIE----QLGTPCPEFMKKLQPTVR-NYVENRPKYAGL 307 +P +D N V + CP+ + L + RP + + Sbjct: 246 TLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 301 >6BSD-A nrPDB Length = 876 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 107/300 (35%), Gaps = 62/300 (20%) Query: 63 RYQNLKPIGSGAQGIVCAAY--------------DAVLDRN--VAIKKLSRPFQNQTHAK 106 R + + +G G G V + VA+K L RP + Sbjct: 572 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNARN 630 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME----- 160 +E+ +M + NII LL V L ++ + M+ +L Q + Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPL------CMITDYMENGDLNQFLSAHQLEDK 684 Query: 161 ----------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 + + + ++ Q+ G+++L + +HRDL N +V + T+K Sbjct: 685 AAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744 Query: 205 ILDFGLARTAGTSFMMTPY---VVTRYYRAPEVILGMGYKENVDIWSVGCIMGE--MVRH 259 I DFG++R V+ + A E IL + D+W+ G + E M+ Sbjct: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 804 Query: 260 KILF-----------PGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR-NYVENRPKYAGL 307 F G + DQ +V CP+ + +L E RP ++ L Sbjct: 805 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864 >3KRL-A nrPDB Length = 335 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 117/316 (37%), Gaps = 44/316 (13%) Query: 27 QVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVL 86 QV I + S + +D + + Q K +G+GA G V A L Sbjct: 13 QVRWKIIESYEGNSYTFIDPT--QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL 70 Query: 87 DRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQ 140 + VA+K L + + + EL +M + H+NI++LL T Sbjct: 71 GKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP----- 124 Query: 141 DVYLVMELM-DANLCQVIQME------------------LDHERMSYLLYQMLCGIKHLH 181 V ++ E +L ++ + L + + Q+ G+ L Sbjct: 125 -VLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLA 183 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM---TPYVVTRYYRAPEVILGM 238 S IHRD+ N+++ + KI DFGLAR + + APE I Sbjct: 184 SKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC 243 Query: 239 GYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQP 292 Y D+WS G ++ E+ +PG ++ K+++ Q+ P P+ + + Sbjct: 244 VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQ 303 Query: 293 TVRN-YVENRPKYAGL 307 +RP + + Sbjct: 304 ACWALEPTHRPTFQQI 319 >3I81-A nrPDB Length = 315 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 116/311 (37%), Gaps = 36/311 (11%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA-----VLDRNVAIKKLSRPFQNQTH 104 V V D ++ + +G G+ G+V + VAIK ++ + Sbjct: 6 DVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEA-ASMRE 64 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDH 163 E +MK N +++ LL V + + ++MELM +L ++ Sbjct: 65 RIEFLNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLRSLRPE 118 Query: 164 ------------ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA 211 +M + ++ G+ +L++ +HRDL N +V D T+KI DFG+ Sbjct: 119 MENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMT 178 Query: 212 RTA-GTSFMMTPYVV--TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRD 267 R T + + +PE + + D+WS G ++ E+ + + G Sbjct: 179 RDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLS 238 Query: 268 YIDQWNKVIE----QLGTPCPEFMKKLQPTVRNY-VENRPKYAGLTFPKLFPDSLFPADS 322 V+E CP+ + +L Y + RP + L + + P Sbjct: 239 NEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF--LEIISSIKEEMEPGFR 296 Query: 323 EHNKLKASQAR 333 E + + + + Sbjct: 297 EVSFYYSEENK 307 >1ZXE-A nrPDB Length = 303 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 128/328 (39%), Gaps = 70/328 (21%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 ++ + +G GA G V A +A+ R AIKK+ + E++L+ +NH+ Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH---TEEKLSTILSEVMLLASLNHQY 63 Query: 123 IISLLNVFTPQKTL-------EEFQDVYLVMELMD-ANLCQVIQME-LDHERMSY--LLY 171 ++ + ++ ++ +++ ME + L +I E L+ +R Y L Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---------------GT 216 Q+L + ++HS GIIHR+LKP NI + +KI DFGLA+ G+ Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 217 SFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 S +T + T Y A EV+ G G Y E +D++S+G I EM+ F K Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKK 240 Query: 276 IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDL 335 + + P + V + Sbjct: 241 LRSVSIEFPPDFDDNKMKVEKKI------------------------------------- 263 Query: 336 LSKMLVIDPAKRISVDDALQHPYINVWY 363 + ++ DP KR L ++ V + Sbjct: 264 IRLLIDHDPNKRPGARTLLNSGWLPVKH 291 >3FME-A nrPDB Length = 290 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 125/312 (40%), Gaps = 58/312 (18%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL-MKCVNH 120 + + +G GA G+V + +A+K++ R N KR +L + M+ V+ Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDC 65 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD------HERMSYLLYQML 174 ++ + DV++ MELMD +L + + +D + + + ++ Sbjct: 66 PFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 175 CGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 ++HLHS +IHRD+KPSN+++ + +K+ DFG++ + Y APE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 234 VI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 I GY DIWS+G M E+ + FP + + ++ + + P P+ Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQL--- 234 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 PAD + ++ L + +R + Sbjct: 235 -----------------------------PADKFSAEFVDFTSQCL-----KKNSKERPT 260 Query: 350 VDDALQHPYINV 361 + +QHP+ + Sbjct: 261 YPELMQHPFFTL 272 >4M7I-A nrPDB Length = 299 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 122/292 (41%), Gaps = 35/292 (11%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L ++ ++ +G G G+V A + V D N AIK++ P + + ++ RE+ + + H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEH 62 Query: 121 KNIISLLNVFTPQKTLEEFQ------DVYLVMELMDA-NLCQVIQMELDHERM-----SY 168 I+ N + + T E+ Q +Y+ M+L NL + E + Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF---------- 218 + Q+ ++ LHS G++HRDLKPSNI D +K+ DFGL Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 219 ---MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 T V T+ Y +PE I G Y VDI+S+G I+ E++ F + + Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL---YPFSTQMERVRTLTD 239 Query: 276 IEQLGTPC------PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPAD 321 + L P P +Q + RP+ + +F D FP Sbjct: 240 VRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGK 291 >3SXS-A nrPDB Length = 268 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 56/260 (21%), Positives = 105/260 (40%), Gaps = 24/260 (9%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + LK +GSG G+V +VA+K + ++ ++E M ++H Sbjct: 7 REEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSH 62 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME---LDHERMSYLLYQMLCG 176 ++ V + + +Y+V E + L ++ L+ ++ + Y + G Sbjct: 63 PKLVKFYGVCSKEYP------IYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEG 116 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---YRAPE 233 + L S IHRDL N +V D +K+ DFG+ R ++ V T++ + APE Sbjct: 117 MAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWSAPE 175 Query: 234 VILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEF----MK 288 V Y D+W+ G +M E+ K+ + + KV + P + Sbjct: 176 VFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIY 235 Query: 289 KLQPTVR-NYVENRPKYAGL 307 ++ + E RP + L Sbjct: 236 QIMYSCWHELPEKRPTFQQL 255 >5UUU-A nrPDB Length = 547 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 123/331 (37%), Gaps = 61/331 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR-AYRELVLMKCV- 118 + + + IG G G V A + A+K L + + A E +++ V Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 119 --NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQM 173 + I+ + F L +++LM+ + M + ++ Sbjct: 257 TGDCPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 310 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 + G++H+H+ +++RDLKP+NI++ ++I D GLA V T Y APE Sbjct: 311 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPE 369 Query: 234 VIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 V+ G+ Y + D +S+GC++ +++R F ++ + Sbjct: 370 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPF------------------------RQHKT 405 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---- 348 ++ ++ + P F + + R LL +L D +R+ Sbjct: 406 KDKHEIDRMTLTMAVELPDSF---------------SPELRSLLEGLLQRDVNRRLGCLG 450 Query: 349 -SVDDALQHPYIN--VWYDPAEVEAPPPQIY 376 + + P+ W + PPP I Sbjct: 451 RGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 481 >4R7H-A nrPDB Length = 343 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 66/318 (20%), Positives = 118/318 (37%), Gaps = 39/318 (12%) Query: 27 QVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVL 86 QV I + S + +D + + Q K +G+GA G V A L Sbjct: 17 QVRWKIIESYEGNSYTFIDPT--QLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL 74 Query: 87 DRN-----VAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQ 140 + VA+K L + + + EL +M + H+NI++LL T + Sbjct: 75 GKEDAVLKVAVKML-KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVIT 133 Query: 141 DVYLVMELMD--------------------ANLCQVIQMELDHERMSYLLYQMLCGIKHL 180 + +L++ L + L+ + + Q+ G+ L Sbjct: 134 EYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFL 193 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM---TPYVVTRYYRAPEVILG 237 S IHRD+ N+++ + KI DFGLAR + + APE I Sbjct: 194 ASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD 253 Query: 238 MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE---QLGTP--CPEFMKKLQ 291 Y D+WS G ++ E+ +PG ++ K+++ Q+ P P+ + + Sbjct: 254 SVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 313 Query: 292 PTVRN-YVENRPKYAGLT 308 +RP + +T Sbjct: 314 QACWALEPTHRPTFQQIT 331 >3PVW-A nrPDB Length = 695 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 123/331 (37%), Gaps = 61/331 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR-AYRELVLMKCV- 118 + + + IG G G V A + A+K L + + A E +++ V Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 119 --NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQM 173 + I+ + F L +++LM+ + M + ++ Sbjct: 248 TGDCPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 + G++H+H+ +++RDLKP+NI++ ++I D GLA V T Y APE Sbjct: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPE 360 Query: 234 VIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 V+ G+ Y + D +S+GC++ +++R F ++ + Sbjct: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPF------------------------RQHKT 396 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI---- 348 ++ ++ + P F + + R LL +L D +R+ Sbjct: 397 KDKHEIDRMTLTMAVELPDSF---------------SPELRSLLEGLLQRDVNRRLGCLG 441 Query: 349 -SVDDALQHPYIN--VWYDPAEVEAPPPQIY 376 + + P+ W + PPP I Sbjct: 442 RGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 >4XI2-A nrPDB Length = 446 Score = 194 bits (494), Expect = 6e-50, Method: Composition-based stats. Identities = 64/324 (19%), Positives = 127/324 (39%), Gaps = 38/324 (11%) Query: 9 CSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVE-----------VGDST 57 CS P +A F ++ I H + S + Y V +G + Sbjct: 124 CSTPQSQYYLAEKHLFSTIPEL--INYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGS 181 Query: 58 FTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 + + K LK +G+G G+V +VAIK + ++ E +M Sbjct: 182 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMSE---DEFIEEAKVMM 237 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM---ELDHERMSYLLYQ 172 ++H+ ++ L V T Q+ ++++ E M + L ++ +++ + Sbjct: 238 NLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 291 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY---Y 229 + +++L S +HRDL N +V +K+ DFGL+R T V +++ + Sbjct: 292 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRW 350 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCP---- 284 PEV++ + DIW+ G +M E+ K+ + + + + L P Sbjct: 351 SPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLAS 410 Query: 285 EFMKKLQPTVR-NYVENRPKYAGL 307 E + + + + RP + L Sbjct: 411 ERVYTIMYSCWHEKADERPSFKIL 434 >5KMM-A nrPDB Length = 329 Score = 194 bits (493), Expect = 8e-50, Method: Composition-based stats. Identities = 51/259 (19%), Positives = 95/259 (36%), Gaps = 39/259 (15%) Query: 69 PIGSGAQGIVCAAYDA-----VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 +G GA G V A VA+K L +++ + RE L+ + H++I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA--SESARQDFQREAELLTMLQHQHI 99 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-----------------LDHER 165 + V T + L +V E M +L + ++ L + Sbjct: 100 VRFFGVCTEGRPL------LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQ 153 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 + + Q+ G+ +L +HRDL N +V +KI DFG++R ++ Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR 213 Query: 226 T---RYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE---- 277 T + PE IL + D+WS G ++ E+ K + + + + + Sbjct: 214 TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGREL 273 Query: 278 QLGTPCPEFMKKLQPTVRN 296 + CP + + Sbjct: 274 ERPRACPPEVYAIMRGCWQ 292 >3CJF-A nrPDB Length = 309 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 108/278 (38%), Gaps = 37/278 (13%) Query: 61 LKRYQNLKPIGSGAQGIVCAA----YDAV-LDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 R KP+G GA G V A D R VA+K L + H EL ++ Sbjct: 26 RDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR-ALMSELKIL 84 Query: 116 -KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH---------- 163 +H N+++LL T + +++E NL ++ + + Sbjct: 85 IHIGHHLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKD 139 Query: 164 ----ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GT 216 E + +Q+ G++ L S IHRDL NI++ +KI DFGLAR Sbjct: 140 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 199 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKV 275 + + APE I Y D+WS G ++ E+ +PG +++ + Sbjct: 200 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 259 Query: 276 IE---QLGTP---CPEFMKKLQPTVRNYVENRPKYAGL 307 ++ ++ P PE + + RP ++ L Sbjct: 260 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSEL 297 >6DBN-A nrPDB Length = 316 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 61/307 (19%), Positives = 117/307 (38%), Gaps = 43/307 (14%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYR 110 D T + + ++ +G G G V VA+K L +P H + Sbjct: 28 DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIADLKK 86 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI---QMELDHERM 166 E+ +++ + H+NI+ + T + L+ME + +L + + + +++ ++ Sbjct: 87 EIEILRNLYHENIVKYKGICTEDG----GNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ 142 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV-- 224 Q+ G+ +L S +HRDL N++V+S+ +KI DFGL + T Sbjct: 143 LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD 202 Query: 225 --VTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 ++ APE ++ + D+WS G + E++ + ++ +G Sbjct: 203 RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYC-----DSDSSPMALFLKMIG-- 255 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 Q TV V + L P PD ++ L+ K Sbjct: 256 ----PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQ---------------LMRKCWEF 296 Query: 343 DPAKRIS 349 P+ R S Sbjct: 297 QPSNRTS 303 >4HVI-A nrPDB Length = 314 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 117/312 (37%), Gaps = 38/312 (12%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAY----DAVLDRNVAIKKLSRPFQNQTHAKRAYR 110 D T + + + +G G G V VA+K+L +Q + R Sbjct: 3 DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ--RDFQR 60 Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA----NLCQVIQMELDHERM 166 E+ ++K ++ I+ V Q + LVME + + + Q + LD R+ Sbjct: 61 EIQILKALHSDFIVKYRGVSYGPG----RQSLRLVMEYLPSGCLRDFLQRHRARLDASRL 116 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT----P 222 Q+ G+++L S +HRDL NI+V+S+ +KI DFGLA+ P Sbjct: 117 LLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREP 176 Query: 223 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRH-------KILF----------PG 265 ++ APE + + D+WS G ++ E+ + F P Sbjct: 177 GQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPA 236 Query: 266 RDYIDQWNKVIEQLGTP--CPEFMKKLQPTVR-NYVENRPKYAGLTFPKLFPDSLFPADS 322 + + + ++L P CP + +L ++RP ++ L S Sbjct: 237 LSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCE 296 Query: 323 EHNKLKASQARD 334 H + + Sbjct: 297 THAFTAHPEGKH 308 >4Y93-A nrPDB Length = 446 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 53/268 (19%), Positives = 109/268 (40%), Gaps = 23/268 (8%) Query: 53 VGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 +G ++ + K LK +G+G G+V +VAIK + ++ E Sbjct: 178 LGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSE---DEFIEE 233 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM---ELDHERMS 167 +M ++H+ ++ L V T Q+ ++++ E M + L ++ +++ Sbjct: 234 AKVMMNLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREMRHRFQTQQLL 287 Query: 168 YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVV 225 + + +++L S +HRDL N +V +K+ DFG+ R T Sbjct: 288 EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKF 347 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCP 284 + +PEV++ + DIW+ G +M E+ K+ + + + + L P P Sbjct: 348 PVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRP 407 Query: 285 ----EFMKKLQPTVR-NYVENRPKYAGL 307 E + + + + RP + L Sbjct: 408 HLASERVYAIMYSCWHEKADERPTFKIL 435 >6E4F-A nrPDB Length = 290 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 55/279 (19%), Positives = 116/279 (41%), Gaps = 27/279 (9%) Query: 45 DNQFYS--VEVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQN 101 +N ++ +G ++ + K LK +G+G G+V +VAIK + + Sbjct: 11 ENLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMS 69 Query: 102 QTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM- 159 + E +M ++H+ ++ L V T Q+ ++++ E M + L ++ Sbjct: 70 E---DEFIEEAKVMMNLSHEKLVQLYGVCTKQRP------IFIITEYMANGCLLNYLREM 120 Query: 160 --ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS 217 +++ + + +++L S +HRDL N +V +K+ DFGL+R Sbjct: 121 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD 180 Query: 218 FMMTPYVVTRY---YRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWN 273 T V +++ + PEV++ + DIW+ G +M E+ K+ + + Sbjct: 181 E-YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE 239 Query: 274 KVIEQLGTPCP----EFMKKLQPTVR-NYVENRPKYAGL 307 + + L P E + + + + RP + L Sbjct: 240 HIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKIL 278 >1U59-A nrPDB Length = 287 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 100/256 (39%), Gaps = 24/256 (9%) Query: 69 PIGSGAQGIVCAAYDAVLDRN--VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 +G G G V + + VAIK L + + + + RE +M +++ I+ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 75 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHS 182 + V + + LVME+ + E+ ++ LL+Q+ G+K+L Sbjct: 76 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV----TRYYRAPEVILGM 238 +HRDL N+++ + KI DFGL++ G + APE I Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 188 Query: 239 GYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE----QLGTPCPEFMKKLQPT 293 + D+WS G M E + + + + + + + CP + L Sbjct: 189 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 248 Query: 294 VRNY-VENRPKYAGLT 308 Y E+RP + + Sbjct: 249 CWIYKWEDRPDFLTVE 264 >5HLW-A nrPDB Length = 299 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 109/258 (42%), Gaps = 24/258 (9%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + IG G G V D A+K L+R + + E ++MK +H N++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLL---YQMLCGIKHL 180 SLL + L +V+ M +L I+ E + + L+ Q+ G+K+L Sbjct: 85 SLLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL 139 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-----TPYVVTRYYRAPEVI 235 S +HRDL N ++ T+K+ DFGLAR T + + A E + Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 236 LGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE--QLGTP--CPEFMKKL 290 + D+WS G ++ E++ +P + D +++ +L P CP+ + ++ Sbjct: 200 QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 259 Query: 291 QPTVRN-YVENRPKYAGL 307 + E RP ++ L Sbjct: 260 MLKCWHPKAEMRPSFSEL 277 >3DLS-A nrPDB Length = 335 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 124/311 (39%), Gaps = 65/311 (20%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP------FQNQTHAKRAYRELVLM 115 ++Y + P+GSGA G V A D ++ V +K + + + + E+ ++ Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV----IQMELDHERMSYLLY 171 V H NII +L++F Q + LVME + L LD SY+ Sbjct: 84 SRVEHANIIKVLDIFENQGFFQ------LVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR 137 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 Q++ + +L IIHRD+K NIV+ D T+K++DFG A + + T Y A Sbjct: 138 QLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197 Query: 232 PEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PEV++G Y +++WS+G + +V + F + + +E P Sbjct: 198 PEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPP------- 244 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 L + + L+S +L P +R ++ Sbjct: 245 -----------------------------------YLVSKELMSLVSGLLQPVPERRTTL 269 Query: 351 DDALQHPYINV 361 + + P++ Sbjct: 270 EKLVTDPWVTQ 280 >3M42-A nrPDB Length = 299 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 62/347 (17%), Positives = 130/347 (37%), Gaps = 81/347 (23%) Query: 60 VLKRYQNL-KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM-KC 117 ++ Y+ + +G G G V ++ A+K L +A RE+ L + Sbjct: 15 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 67 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQME----LDHERMSYLLYQ 172 +I+ +++V+ + + + +VME +D L IQ S ++ Sbjct: 68 SQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 125 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 + I++LHS I HRD+KP N++ S + LK+ DFG A+ Sbjct: 126 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-------------- 171 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 G Y ++ D+WS+G IM ++ F Sbjct: 172 -------GEKYDKSCDMWSLGVIMYILLCGYPPFY-----------------------SN 201 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 + ++ R + FP + + + + L+ +L +P +R++ Sbjct: 202 HGLAISPGMKTRIRMGQYEFPNPEWSEV-----------SEEVKMLIRNLLKTEPTQRMT 250 Query: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYK 396 + + + HP+I + P ++ ++ + + E W+++ + Sbjct: 251 ITEFMNHPWIMQ-----STKVPQTPLHTSRVLKEDK--ERWEDVKEE 290 >5AMN-A nrPDB Length = 299 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 58/284 (20%), Positives = 108/284 (38%), Gaps = 35/284 (12%) Query: 53 VGDSTFTVLKR-YQNLKPIGSGAQGIVCAAYDAVLD-----RNVAIKKLSRPFQNQTHAK 106 + D + ++ K +G G G V A L VA+K L + + + + Sbjct: 13 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELR 71 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------ 160 E ++K VNH ++I L + L L++E + E Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGP 125 Query: 161 -------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART 213 L + +Q+ G+++L ++HRDL NI+V +KI DFGL+R Sbjct: 126 GYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD 185 Query: 214 A---GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYI 269 + + + + A E + Y D+WS G ++ E+V +PG Sbjct: 186 VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE 245 Query: 270 DQWNKV-----IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLT 308 +N + +E+ E + + + + RP +A ++ Sbjct: 246 RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS 289 >6FER-A nrPDB Length = 309 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 104/288 (36%), Gaps = 53/288 (18%) Query: 68 KPIGSGAQGIVCAAYDAVLDR----------------NVAIKKLSRPFQNQTHAKRAYRE 111 + +G G G V +++ VA+K L R N+ +E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML-RADANKNARNDFLKE 73 Query: 112 LVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHER----- 165 + +M + NII LL V L ++ E M+ +L Q + Sbjct: 74 IKIMSRLKDPNIIHLLAVCITDDPL------CMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 166 -------MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 + ++ Q+ G+K+L S +HRDL N +V + T+KI DFG++R + Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 187 Query: 219 MMTPY---VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP----------- 264 V+ + + E IL + D+W+ G + E P Sbjct: 188 YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIE 247 Query: 265 --GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR-NYVENRPKYAGLTF 309 G + DQ + CP+ + KL + +NRP + + Sbjct: 248 NTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHL 295 >3C1X-A nrPDB Length = 373 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 109/258 (42%), Gaps = 24/258 (9%) Query: 68 KPIGSGAQGIVCAAYDAVLDRN---VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + IG G G V D A+K L+R + + E ++MK +H N++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSYLL---YQMLCGIKHL 180 SLL + L +V+ M +L I+ E + + L+ Q+ G+K L Sbjct: 154 SLLGIC-----LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFL 208 Query: 181 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-----TAGTSFMMTPYVVTRYYRAPEVI 235 S +HRDL N ++ T+K+ DFGLAR + T + + A E + Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL 268 Query: 236 LGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE--QLGTP--CPEFMKKL 290 + D+WS G ++ E++ +P + D +++ +L P CP+ + ++ Sbjct: 269 QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEV 328 Query: 291 QPTVRN-YVENRPKYAGL 307 + E RP ++ L Sbjct: 329 MLKCWHPKAEMRPSFSEL 346 >3PP0-A nrPDB Length = 338 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 112/300 (37%), Gaps = 29/300 (9%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNV----AIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 + +K +GSGA G V NV AIK L + + K E +M V Sbjct: 20 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN-KEILDEAYVMAGVGS 78 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM---ELDHERMSYLLYQMLCG 176 + LL + V LV +LM L ++ L + + Q+ G Sbjct: 79 PYVSRLLGICLTST-------VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKG 131 Query: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMMTPYVVTRYYRAPE 233 + +L ++HRDL N++VKS +KI DFGLAR T + V + A E Sbjct: 132 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 191 Query: 234 VILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE----FMK 288 IL + D+WS G + E++ + G + + + + P P + Sbjct: 192 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 251 Query: 289 KLQPTVRNYV-ENRPKYAGL--TFPKLFPDSLFPADSEHNKLKASQARD--LLSKMLVID 343 + E RP++ L F ++ D ++ L + D +L D Sbjct: 252 MIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDD 311 >5U6C-A nrPDB Length = 315 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 49/265 (18%), Positives = 100/265 (37%), Gaps = 22/265 (8%) Query: 66 NLKPIGSGAQGIVCAAYDAV---LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 K +G G G V VA+K + +Q + E MK +H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ--------MELDHERMSYLLYQM 173 ++ LL V + + +++ M +L + + + + + + Sbjct: 100 VMRLLGVCIEMSS-QGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV---TRYYR 230 G+++L + +HRDL N +++ D T+ + DFGL++ + + + Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWI 218 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVI--EQLGTP---CP 284 A E + Y D+W+ G M E+ +PG + ++ ++ +L P Sbjct: 219 AIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTF 309 E + + R +RP ++ L Sbjct: 279 ELYEIMYSCWRTDPLDRPTFSVLRL 303 >6GVJ-A nrPDB Length = 429 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 122/320 (38%), Gaps = 65/320 (20%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV--NHK 121 Y LK IGSG V + + AIK ++ + E+ + + + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCGIKH 179 II L + Q +Y+VME + +L ++ + +D ML + Sbjct: 205 KIIRLYDYEITD------QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 258 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVIL 236 +H GI+H DLKP+N ++ D LK++DFG+A TS + V T Y PE I Sbjct: 259 IHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 317 Query: 237 GMGYKEN-----------VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 M D+WS+GCI+ M K F ++I Q+ Sbjct: 318 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---------QQIINQIS----- 363 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 KL + E + FP + +D+L L DP Sbjct: 364 ---KLHAIIDPNHE-------IEFPDI---------------PEKDLQDVLKCCLKRDPK 398 Query: 346 KRISVDDALQHPYINVWYDP 365 +RIS+ + L HPY+ + P Sbjct: 399 QRISIPELLAHPYVQIQTHP 418 >5GNK-A nrPDB Length = 297 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 111/272 (40%), Gaps = 27/272 (9%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNV----AIKKLSRPFQNQTHAKRAYRELVLMKCV 118 ++ +K +GSGA G V V AIK+L + + K E +M V Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASV 78 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH---ERMSYLLYQML 174 ++ ++ LL + V L+M+LM L ++ D+ + + Q+ Sbjct: 79 DNPHVCRLLGICLTST-------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMMTPYVVTRYYRA 231 G+ +L ++HRDL N++VK+ +KI DFGLA+ G + V + A Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE----F 286 E IL Y D+WS G + E++ + G + + + + P P Sbjct: 192 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 251 Query: 287 MKKLQPTVRNYV-ENRPKYAG--LTFPKLFPD 315 + + ++RPK+ + F K+ D Sbjct: 252 VYMIMVKCWMIDADSRPKFRELIIEFSKMARD 283 >5HVK-A nrPDB Length = 315 Score = 191 bits (484), Expect = 8e-49, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 98/267 (36%), Gaps = 34/267 (12%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +G G G + +K+L R ++ + +E+ +M+C+ H N++ + Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRF--DEETQRTFLKEVKVMRCLEHPNVLKFI 77 Query: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD----HERMSYLLYQMLCGIKHLHSA 183 V K L + E + + I +D + + G+ +LHS Sbjct: 78 GVLYKDKRLN------FITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 131 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTA---------------GTSFMMTPYVVTRY 228 IIHR+L N +V+ + + + DFGLAR V Y Sbjct: 132 NIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 191 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRH------KILFPGRDYIDQWNKVIEQLGTP 282 + APE+I G Y E VD++S G ++ E++ + ++ + Sbjct: 192 WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPN 251 Query: 283 CPE-FMKKLQPTVRNYVENRPKYAGLT 308 CP F E RP + L Sbjct: 252 CPPSFFPITVRCCDLDPEKRPSFVKLE 278 >2OZO-A nrPDB Length = 613 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 100/256 (39%), Gaps = 24/256 (9%) Query: 69 PIGSGAQGIVCAAYDAVLDRN--VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISL 126 +G G G V + + VAIK L + + + + RE +M +++ I+ L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 401 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHS 182 + V + + LVME+ + E+ ++ LL+Q+ G+K+L Sbjct: 402 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV----TRYYRAPEVILGM 238 +HR+L N+++ + KI DFGL++ G + APE I Sbjct: 455 KNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 Query: 239 GYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIE----QLGTPCPEFMKKLQPT 293 + D+WS G M E + + + + + + + CP + L Sbjct: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 Query: 294 VRNY-VENRPKYAGLT 308 Y E+RP + + Sbjct: 575 CWIYKWEDRPDFLTVE 590 >5GRN-A nrPDB Length = 356 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 110/294 (37%), Gaps = 41/294 (13%) Query: 55 DSTFTVLKR-YQNLKPIGSGAQGIVCAAYDAVLDR-----NVAIKKLSRPFQNQTHAKRA 108 DS + + + +GSGA G V L R VA+K L +P + + Sbjct: 38 DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQAL 96 Query: 109 YRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELM-------DANLCQVIQME 160 EL +M + H NI++LL T + + +L+ D+ L + Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSM 156 Query: 161 LDHE----------------RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 LD E + YQ+ G++ L S +HRDL N+++ +K Sbjct: 157 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 205 ILDFGLARTAGTSFMMTPYVVT---RYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HK 260 I DFGLAR T + APE I Y D+WS G ++ E+ Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGG 276 Query: 261 ILFPGRDYIDQ-WNKVIEQLGTPCPEF----MKKLQPTVRN-YVENRPKYAGLT 308 +PG +NK+ P+ + ++ N E RP + L+ Sbjct: 277 TPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLS 330 >3PLS-A nrPDB Length = 298 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 108/257 (42%), Gaps = 22/257 (8%) Query: 68 KPIGSGAQGIVCAA--YDAVLDR-NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + IG G G+V D +R AIK LSR + Q + RE +LM+ +NH N++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVL 85 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLL---YQMLCGIKHLH 181 +L+ + P + L Y+ +L Q I+ + + L+ Q+ G+++L Sbjct: 86 ALIGIMLPPEGLPHVLLPYM----CHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY-----VVTRYYRAPEVIL 236 +HRDL N ++ T+K+ DFGLAR + + + A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQ 201 Query: 237 GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYID--QWNKVIEQLGTP--CPEFMKKLQ 291 + D+WS G ++ E++ + D D + +L P CP+ + ++ Sbjct: 202 TYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVM 261 Query: 292 PTVRN-YVENRPKYAGL 307 RP + L Sbjct: 262 QQCWEADPAVRPTFRVL 278 >3LZB-A nrPDB Length = 327 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 110/272 (40%), Gaps = 27/272 (9%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNV----AIKKLSRPFQNQTHAKRAYRELVLMKCV 118 ++ +K +GSGA G V V AIK+L + + K E +M V Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASV 74 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH---ERMSYLLYQML 174 ++ ++ LL + V L+ +LM L ++ D+ + + Q+ Sbjct: 75 DNPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 127 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMMTPYVVTRYYRA 231 G+ +L ++HRDL N++VK+ +KI DFGLA+ G + V + A Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 187 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE----F 286 E IL Y D+WS G + E++ + G + + + + P P Sbjct: 188 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 247 Query: 287 MKKLQPTVRNYV-ENRPKYAG--LTFPKLFPD 315 + + ++RPK+ + F K+ D Sbjct: 248 VYMIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >3HMP-A nrPDB Length = 342 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 83/362 (22%), Positives = 135/362 (37%), Gaps = 66/362 (18%) Query: 23 GFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKR-YQNLKPIGSGAQGIVCAA 81 G + + +H + D+ + + +V R Y LK IGSG V Sbjct: 16 GMKETAAAKFERQHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQV 75 Query: 82 YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV--NHKNIISLLNVFTPQKTLEEF 139 + + AIK ++ + E+ + + + II L + Sbjct: 76 LNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITD------ 128 Query: 140 QDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 197 Q +Y+VME + +L ++ + +D ML + +H GI+H DLKP+N ++ Sbjct: 129 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI 188 Query: 198 KSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVILGMGYKEN----------- 243 D LK++DFG+A TS + V T Y PE I M Sbjct: 189 V-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPK 247 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPK 303 D+WS+GCI+ M K F ++I Q+ KL + E Sbjct: 248 SDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAIIDPNHE---- 286 Query: 304 YAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWY 363 + FP + +D+L L DP +RIS+ + L HPY+ + Sbjct: 287 ---IEFPDI---------------PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 328 Query: 364 DP 365 P Sbjct: 329 HP 330 >3G0E-A nrPDB Length = 336 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 70/285 (24%), Positives = 110/285 (38%), Gaps = 33/285 (11%) Query: 55 DSTFTVLK-RYQNLKPIGSGAQGIVCAAYDAVLDR-----NVAIKKLSRPFQNQTHAKRA 108 D + + R K +G+GA G V A L + VA+K L +P + T + Sbjct: 38 DHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREAL 96 Query: 109 YRELVLMKCV-NHKNIISLLNVFT---PQKTLEEFQDVYLVMELMDANLCQVIQMELDHE 164 EL ++ + NH NI++LL T P + E+ ++ + I + Sbjct: 97 MSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPA 156 Query: 165 RMS------------YLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR 212 M YQ+ G+ L S IHRDL NI++ KI DFGLAR Sbjct: 157 IMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR 216 Query: 213 TAGTSFMMTPYVVTR---YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDY 268 R + APE I Y D+WS G + E+ +PG Sbjct: 217 DIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPV 276 Query: 269 IDQWNKVIE---QLGTP--CPEFMKKLQPTVRN-YVENRPKYAGL 307 ++ K+I+ ++ +P P M + T + RP + + Sbjct: 277 DSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQI 321 >3LLT-A nrPDB Length = 360 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 66/336 (19%), Positives = 127/336 (37%), Gaps = 51/336 (15%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + ++ +G G G V + A+K + + + + A E ++K + + +I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNI---KKYTRSAKIEADILKKIQNDDI 93 Query: 124 -----ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQML 174 + + + L+ E + +L ++I E + ++L Sbjct: 94 NNNNIVKYHG------KFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEIL 147 Query: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCT-------------------------LKILDFG 209 + +L + H DLKP NI++ +K++DFG Sbjct: 148 KALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFG 207 Query: 210 LARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYI 269 A + TR YRAPEVIL +G+ + D+WS GC++ E+ +LF +++ Sbjct: 208 CATFKSDYH--GSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHM 265 Query: 270 DQWNKVIEQLGTPCPEFM-----KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 + ++E + P P+ M K N E + + + + Sbjct: 266 EHLA-MMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLY 324 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 +K D L +L IDP R S + L+H ++ Sbjct: 325 KIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4TPT-A nrPDB Length = 303 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 106/273 (38%), Gaps = 41/273 (15%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +G G G + + +K+L R ++ K E+ +M+ ++H N++ + Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRC--DEETQKTFLTEVKVMRSLDHPNVLKFI 63 Query: 128 NVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCGIKHLHSAG 184 V K L L+ E ++ L ++ ++ + G+ +LHS Sbjct: 64 GVLYKDKKLN------LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 185 IIHRDLKPSNIVVKSDCTLKILDFGLARTA---------------------GTSFMMTPY 223 IIHRDL N ++K D T+ + DFGL+R Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 224 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ----- 278 V Y+ APE++ G Y E VDI+S G ++ E++ ++ + + Sbjct: 178 VGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 279 --LGTPCPE-FMKKLQPTVRNYVENRPKYAGLT 308 + T CP F R E+RP ++ L Sbjct: 237 KFVPTDCPPAFFPLAAICCRLEPESRPAFSKLE 269 >5AP3-A nrPDB Length = 313 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 122/320 (38%), Gaps = 65/320 (20%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV--NHK 121 Y LK IGSG V + + AIK ++ + E+ + + + Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCGIKH 179 II L + Q +Y+VME + +L ++ + +D ML + Sbjct: 89 KIIRLYDYEITD------QYIYMVMECGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHT 142 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVIL 236 +H GI+H DLKP+N ++ D LK++DFG+A TS + V T Y PE I Sbjct: 143 IHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 201 Query: 237 GMGYKEN-----------VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 M D+WS+GCI+ M K F ++I Q+ Sbjct: 202 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---------QQIINQIS----- 247 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 KL + E + FP + +D+L L DP Sbjct: 248 ---KLHAIIDPNHE-------IEFPDI---------------PEKDLQDVLKCCLKRDPK 282 Query: 346 KRISVDDALQHPYINVWYDP 365 +RIS+ + L HPY+ + P Sbjct: 283 QRISIPELLAHPYVQIQTHP 302 >6B2Q-A nrPDB Length = 317 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 65/215 (30%), Positives = 101/215 (46%), Gaps = 7/215 (3%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMK 116 T+ RY+ + I +G G V A D L R VA+K L F + +R E Sbjct: 28 VTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTA 87 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQM 173 +NH I S+ + + + E + YLVMEL++ L V++ L +L Q Sbjct: 88 MLNHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 146 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP--YVVTRYYRA 231 ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + + T Y A Sbjct: 147 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 206 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGR 266 PE LG D++S+G + E V K F G Sbjct: 207 PEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 65/215 (30%), Positives = 101/215 (46%), Gaps = 7/215 (3%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMK 116 T+ RY+ + I +G G V A D L R VA+K L F + +R E Sbjct: 8 VTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTA 67 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQM 173 +NH I S+ + + + E + YLVMEL++ L V++ L +L Q Sbjct: 68 MLNHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 126 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP--YVVTRYYRA 231 ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + + T Y A Sbjct: 127 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 186 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGR 266 PE LG D++S+G + E V K F G Sbjct: 187 PEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 65/215 (30%), Positives = 101/215 (46%), Gaps = 7/215 (3%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMK 116 T+ RY+ + I +G G V A D L R VA+K L F + +R E Sbjct: 7 VTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTA 66 Query: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQM 173 +NH I S+ + + + E + YLVMEL++ L V++ L +L Q Sbjct: 67 MLNHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 125 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP--YVVTRYYRA 231 ++ H+AG++HRD+KP NI++ +KI DFG+A+ + + + T Y A Sbjct: 126 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 185 Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGR 266 PE LG D++S+G + E V K F G Sbjct: 186 PEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 220 >5FM2-A nrPDB Length = 355 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 108/298 (36%), Gaps = 49/298 (16%) Query: 53 VGDSTFTVLKR-YQNLKPIGSGAQGIVCAAYDAVLD-----RNVAIKKLSRPFQNQTHAK 106 + D + ++ K +G G G V A L VA+K L + + + + Sbjct: 54 LEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELR 112 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME------ 160 E ++K VNH ++I L + L L++E + E Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGP 166 Query: 161 ---------------------LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS 199 L + +Q+ G+++L ++HRDL NI+V Sbjct: 167 GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE 226 Query: 200 DCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM 256 +KI DFGL+R + + + + A E + Y D+WS G ++ E+ Sbjct: 227 GRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEI 286 Query: 257 VR-HKILFPGRDYIDQWNKV-----IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLT 308 V +PG +N + +E+ E + + + + RP +A ++ Sbjct: 287 VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS 344 >2A1A-B nrPDB Length = 284 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 68/290 (23%), Positives = 122/290 (42%), Gaps = 29/290 (10%) Query: 56 STFTVLKRY----QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRE 111 TV KR+ + ++ IGSG G V A + + IK++ + ++A RE Sbjct: 1 GAHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY------NNEKAERE 54 Query: 112 LVLMKCVNHKNIISLLNVF----------TPQKTLEEFQDVYLVMELMD-ANLCQVIQME 160 + + ++H NI+ + + + + + +++ ME D L Q I+ Sbjct: 55 VKALAKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKR 114 Query: 161 ----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 216 LD L Q+ G+ ++HS +I+RDLKPSNI + +KI DFGL + Sbjct: 115 RGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKN 174 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV-RHKILFPGRD-YIDQWNK 274 T T Y +PE I Y + VD++++G I+ E++ F + D + Sbjct: 175 DGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDG 234 Query: 275 VIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 +I + + + LQ + E+RP + + + H Sbjct: 235 IISDIFDKKEKTL--LQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERH 282 >2ZMD-A nrPDB Length = 390 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 82/362 (22%), Positives = 134/362 (37%), Gaps = 66/362 (18%) Query: 23 GFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKR-YQNLKPIGSGAQGIVCAA 81 G + + +H + D+ + + +V R Y LK IGSG V Sbjct: 16 GMKETAAAKFERQHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQV 75 Query: 82 YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV--NHKNIISLLNVFTPQKTLEEF 139 + + AIK ++ + E+ + + + II L + Sbjct: 76 LNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITD------ 128 Query: 140 QDVYLVMELMDANLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 197 Q +Y+VME + +L ++ + +D ML + +H GI+H DLKP+N ++ Sbjct: 129 QYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI 188 Query: 198 KSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVILGMGYKEN----------- 243 D LK++DFG+A TS + V Y PE I M Sbjct: 189 V-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPK 247 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPK 303 D+WS+GCI+ M K F ++I Q+ KL + E Sbjct: 248 SDVWSLGCILYYMTYGKTPF---------QQIINQIS--------KLHAIIDPNHE---- 286 Query: 304 YAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWY 363 + FP + +D+L L DP +RIS+ + L HPY+ + Sbjct: 287 ---IEFPDI---------------PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 328 Query: 364 DP 365 P Sbjct: 329 HP 330 >6CTH-A nrPDB Length = 309 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 53/201 (26%), Positives = 90/201 (44%), Gaps = 17/201 (8%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLN 128 +G G G V + D +A+KK+SR ++ K E+ ++ + HKN++ L+ Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKVSRA--SKQGIKEYASEVKIISRLRHKNLVKLIG 79 Query: 129 VFTPQKTLEEFQDVYLVMELM-DANLCQVI---QMELDHERMSYLLYQMLCGIKHLHSAG 184 E ++ LV E M + +L I + L E ++ + + +LH G Sbjct: 80 WC------HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEG 133 Query: 185 ---IIHRDLKPSNIVVKSDCTLKILDFGLARTAGT--SFMMTPYVVTRYYRAPEVILGMG 239 ++HRD+K SNI++ S K+ DFGLAR T T Y APE + Sbjct: 134 DHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 240 YKENVDIWSVGCIMGEMVRHK 260 + D++S G + E+ + Sbjct: 194 ASKESDVYSFGVVALEIASGR 214 >4YFF-A nrPDB Length = 311 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 114/286 (39%), Gaps = 23/286 (8%) Query: 38 NMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS- 96 +M+K K D + L + + IGSG+ G V ++ VAIK+ Sbjct: 18 SMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRA 75 Query: 97 RPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN---- 152 + +++ RE+ ++ +NH +I + L + +V + + Sbjct: 76 NTYCSKSDVDMFCREVSILCQLNHPCVIQFVGAC-----LNDPSQFAIVTQYISGGSLFS 130 Query: 153 LCQVIQMELDHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGL 210 L + LD + + + G+++LH+ IIHRDL NI++ D + DFG Sbjct: 131 LLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGE 190 Query: 211 ARTAG--TSFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILF---- 263 +R MT + APEV Y D++S + E++ +I F Sbjct: 191 SRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLK 250 Query: 264 PGRDYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRN-YVENRPKYAGL 307 P D ++ + +G P+ + L N E RP+++ + Sbjct: 251 PAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEV 296 >3UIU-A nrPDB Length = 306 Score = 184 bits (466), Expect = 9e-47, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 125/304 (41%), Gaps = 42/304 (13%) Query: 55 DSTFTVLKRY----QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR 110 ++ +TV KR+ + ++ IGSG G V A + + I+++ + ++A R Sbjct: 1 ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKY------NNEKAER 54 Query: 111 ELVLMKCVNHKNIISLLNVF-----------------------TPQKTLEEFQDVYLVME 147 E+ + ++H NI+ + + + + + +++ ME Sbjct: 55 EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQME 114 Query: 148 LMD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT 202 D L Q I+ LD L Q+ G+ ++HS +IHRDLKPSNI + Sbjct: 115 FCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ 174 Query: 203 LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMV-RHKI 261 +KI DFGL + T T Y +PE I Y + VD++++G I+ E++ Sbjct: 175 VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDT 234 Query: 262 LFPGRD-YIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA 320 F + D + +I + + + LQ + E+RP + + Sbjct: 235 AFETSKFFTDLRDGIISDIFDKKEKTL--LQKLLSKKPEDRPNTSEILRTLTVWKKSPEK 292 Query: 321 DSEH 324 + H Sbjct: 293 NERH 296 >4LRM-A nrPDB Length = 334 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 110/275 (40%), Gaps = 30/275 (10%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNV----AIKKLSRPFQNQTHAKRAYRELVLMKCV 118 ++ +K +GSGA G V V AIK+L + + K E +M V Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-KEILDEAYVMASV 78 Query: 119 NHK---NIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH---ERMSYLLY 171 ++ ++ LL + V L+ +LM L ++ D+ + + Sbjct: 79 DNPGNPHVCRLLGICLTST-------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV 131 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMMTPYVVTRY 228 Q+ G+ +L ++HRDL N++VK+ +KI DFGLA+ G + V Sbjct: 132 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK 191 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPE-- 285 + A E IL Y D+WS G + E++ + G + + + + P P Sbjct: 192 WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPIC 251 Query: 286 --FMKKLQPTVRNYV-ENRPKYAG--LTFPKLFPD 315 + + ++RPK+ + F K+ D Sbjct: 252 TIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 286 >3BGP-A nrPDB Length = 333 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 125/326 (38%), Gaps = 67/326 (20%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ----THAKRAY 109 G + +YQ +GSG G V + + VAIK + + + + R Sbjct: 48 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 107 Query: 110 RELVLMKCVNHKN--IISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVI--QMELDH 163 E+VL+K V+ +I LL+ F + L++E + +L I + L Sbjct: 108 MEVVLLKKVSSGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQE 161 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTP 222 E +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T Sbjct: 162 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTD 220 Query: 223 YVVTRYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 + TR Y PE I Y + +WS+G ++ +MV I F + I + Q Sbjct: 221 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ--- 277 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 +S+ + L+ L Sbjct: 278 ---------------------------------------------RVSSECQHLIRWCLA 292 Query: 342 IDPAKRISVDDALQHPYINVWYDPAE 367 + P+ R + ++ HP++ P E Sbjct: 293 LRPSDRPTFEEIQNHPWMQDVLLPQE 318 >5UIU-A nrPDB Length = 323 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 100/238 (42%), Gaps = 35/238 (14%) Query: 50 SVEVGDSTFTVLKRYQNL--------KPI-------GSGAQGIVCAAYDAVLDRNVAIKK 94 S+EV D+ F Y+ +PI G G G+V Y V + VA+KK Sbjct: 20 SLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGY--VNNTTVAVKK 77 Query: 95 LSR--PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DA 151 L+ + ++ +E+ +M H+N++ LL + D+ LV M + Sbjct: 78 LAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGF------SSDGDDLCLVYVYMPNG 131 Query: 152 NLCQVIQ-----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 +L + L + GI LH IHRD+K +NI++ T KI Sbjct: 132 SLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKIS 191 Query: 207 DFGLARTAG---TSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKI 261 DFGLAR + + M + V T Y APE + G DI+S G ++ E++ Sbjct: 192 DFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPKSDIYSFGVVLLEIITGLP 248 >5TUR-A nrPDB Length = 404 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 125/326 (38%), Gaps = 67/326 (20%) Query: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ----THAKRAY 109 G + +YQ +GSG G V + + VAIK + + + + R Sbjct: 119 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 178 Query: 110 RELVLMKCVNHKN--IISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVI--QMELDH 163 E+VL+K V+ +I LL+ F + L++E + +L I + L Sbjct: 179 MEVVLLKKVSSGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQE 232 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTP 222 E +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T Sbjct: 233 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTD 291 Query: 223 YVVTRYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 + TR Y PE I Y + +WS+G ++ +MV I F + I + Q Sbjct: 292 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ--- 348 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 +S+ + L+ L Sbjct: 349 ---------------------------------------------RVSSECQHLIRWCLA 363 Query: 342 IDPAKRISVDDALQHPYINVWYDPAE 367 + P+ R + ++ HP++ P E Sbjct: 364 LRPSDRPTFEEIQNHPWMQDVLLPQE 389 >5VD3-A nrPDB Length = 311 Score = 181 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 77/346 (22%), Positives = 125/346 (36%), Gaps = 66/346 (19%) Query: 28 VDVSYIAKHY-NMSKSKVDNQFYSVEVGD-----------STFTVLKRYQNLKPIGSGAQ 75 VD+ ++ +M + + + E + + +Q L +G G+ Sbjct: 11 VDLGTENLYFQSMHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSY 70 Query: 76 GIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQK 134 G V R A+K+ PF+ R E+ + V H + L ++ Sbjct: 71 GEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRL------EQ 124 Query: 135 TLEEFQDVYLVMELMDANL---CQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLK 191 EE +YL EL +L C+ L ++ L L + HLHS G++H D+K Sbjct: 125 AWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVK 184 Query: 192 PSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGC 251 P+NI + K+ DFGL GT+ Y APE++ G Y D++S+G Sbjct: 185 PANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG-SYGTAADVFSLGL 243 Query: 252 IMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK 311 + E+ + L G + Q + G PEF L Sbjct: 244 TILEVACNMELPHGGEGWQQLRQ-----GYLPPEFTAGL--------------------- 277 Query: 312 LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 +S+ R +L ML DP R + + L P Sbjct: 278 -----------------SSELRSVLVMMLEPDPKLRATAEALLALP 306 >4FL3-A nrPDB Length = 635 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 63/257 (24%), Positives = 110/257 (42%), Gaps = 22/257 (8%) Query: 68 KPIGSGAQGIVCAAYDA--VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 K +GSG G V Y + + VA+K L + E +M+ +++ I+ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHS 182 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM----TPYVVTRYYRAPEVILGM 238 + +HRDL N+++ + KI DFGL++ T + APE I Sbjct: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 Query: 239 GYKENVDIWSVGCIMGEMVR-HKILFPGR--DYIDQWNKVIEQLGTP--CPEFMKKLQPT 293 + D+WS G +M E + + G + + E++G P CP M L Sbjct: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 Query: 294 VRNY-VENRPKYAGLTF 309 Y VENRP +A + Sbjct: 608 CWTYDVENRPGFAAVEL 624 >4RC3-A nrPDB Length = 289 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 123/317 (38%), Gaps = 67/317 (21%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ----THAKRAYRELVLMKCV 118 +YQ +GSG G V + + VAIK + + + + R E+VL+K V Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 119 NHKN--IISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVI--QMELDHERMSYLLYQ 172 + +I LL+ F + L++E + +L I + L E +Q Sbjct: 73 SSGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQEELARSFFWQ 126 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 +L ++H H+ G++HRD+K NI++ + LK++DFG + + T + TR Y Sbjct: 127 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSP 185 Query: 232 PEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 PE I Y + +WS+G ++ +MV I F + I + Q Sbjct: 186 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ------------ 233 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 +S+ + L+ L + P+ R + Sbjct: 234 ------------------------------------RVSSECQHLIRWCLALRPSDRPTF 257 Query: 351 DDALQHPYINVWYDPAE 367 ++ HP++ P E Sbjct: 258 EEIQNHPWMQDVLLPQE 274 >3ZZW-A nrPDB Length = 289 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 108/270 (40%), Gaps = 28/270 (10%) Query: 65 QNLKPIGSGAQGIVCAAYD-----AVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 + ++ +G G V + + VAIK L + + E +L + Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEFRHEAMLRARLQ 70 Query: 120 HKNIISLLNVFTPQKTLEEFQDVY--------LVM-----ELMDANLCQVIQMELDHERM 166 H N++ LL V T + L LVM ++ + + ++ L+ Sbjct: 71 HPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDF 130 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMT---PY 223 +L+ Q+ G+++L S ++H+DL N++V +KI D GL R + Sbjct: 131 VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNS 190 Query: 224 VVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTP 282 ++ + APE I+ + + DIWS G ++ E+ + G D + + P Sbjct: 191 LLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLP 250 Query: 283 CPE----FMKKLQPTVRN-YVENRPKYAGL 307 CP+ ++ L N + RP++ + Sbjct: 251 CPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5C26-A nrPDB Length = 299 Score = 177 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 63/257 (24%), Positives = 110/257 (42%), Gaps = 22/257 (8%) Query: 68 KPIGSGAQGIVCAAYDA--VLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 K +GSG G V Y + + VA+K L + E +M+ +++ I+ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ--MELDHERMSYLLYQMLCGIKHLHS 182 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 93 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 145 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM----TPYVVTRYYRAPEVILGM 238 + +HRDL N+++ + KI DFGL++ T + APE I Sbjct: 146 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 205 Query: 239 GYKENVDIWSVGCIMGEMVR-HKILFPGR--DYIDQWNKVIEQLGTP--CPEFMKKLQPT 293 + D+WS G +M E + + G + + E++G P CP M L Sbjct: 206 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 265 Query: 294 VRNY-VENRPKYAGLTF 309 Y VENRP +A + Sbjct: 266 CWTYDVENRPGFAAVEL 282 >4NEU-A nrPDB Length = 333 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 107/290 (36%), Gaps = 37/290 (12%) Query: 72 SGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFT 131 SG G V + + +K + + H + E +M + H ++ LL V Sbjct: 34 SGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII 92 Query: 132 PQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMS--YLLYQMLCGIKHLHSAGIIHR 188 + LVME M+ NL V++ E+ ++ +++ G+ +LH G+IH+ Sbjct: 93 EEG------KYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHK 146 Query: 189 DLKPSNIVVKSDCTLKILDFGLARTA--------------GTSFMMTPYVVTRYYRAPEV 234 DLKP NI+V +D +KI D GLA T YY APE Sbjct: 147 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 206 Query: 235 ILG--MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP--------CP 284 + E D++S ++ + +K + Q I+ P CP Sbjct: 207 LNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCP 266 Query: 285 EFMKKLQPTVRN-YVENRPKYAGLT--FPKLFPDSLFPADSEHNKLKASQ 331 + L E RP + G+ F + L + E K + Sbjct: 267 REIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKE 316 >5TOS-A nrPDB Length = 395 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 70/331 (21%), Positives = 120/331 (36%), Gaps = 57/331 (17%) Query: 50 SVEVGDSTFTVLK----RYQNLKPIGSGAQGIVCAAY---------DAVLDRNVAIKKLS 96 S V TF LK ++ IG G G V + +A+KKL+ Sbjct: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 Query: 97 RPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQ 155 + + + E+ + ++H N++ L+ E + LV E M +L Sbjct: 109 Q--EGFQGHREWLTEINYLGQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKGSLEN 160 Query: 156 VIQME------LDHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILD 207 + L + G+ LHS +I+RD+K SNI++ +D K+ D Sbjct: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 Query: 208 FGLAR---TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 FGLAR S++ T + T Y APE + D++S G ++ E++ K Sbjct: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK---- 276 Query: 265 GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEH 324 L P + L R Y+ ++ K L P ++ Sbjct: 277 ------------RALDHNRPAKEENLVDWARPYLTSKRKVL-LIVDNRLDTQYLPEEAVR 323 Query: 325 NKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 A + L +P R ++D ++ Sbjct: 324 MASVAV-------QCLSFEPKSRPTMDQVVR 347 >3AOX-A nrPDB Length = 344 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 53/283 (18%), Positives = 100/283 (35%), Gaps = 34/283 (12%) Query: 52 EVGDSTFTVLKRYQNLKPIGSGAQGIVCAAY-----DAVLDRNVAIKKLSRPFQNQTHAK 106 + D K ++ +G GA G V + VA+K L Q Sbjct: 37 SISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL- 95 Query: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQ------- 158 E +++ NH+NI+ + V ++++ELM +L ++ Sbjct: 96 DFLMEALIISKFNHQNIVRCIGVSLQSLPR------FILLELMAGGDLKSFLRETRPRPS 149 Query: 159 --MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC---TLKILDFGLART 213 L + ++ + CG ++L IHRD+ N ++ KI DFG+AR Sbjct: 150 QPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 209 Query: 214 AG-TSFMMTPYVV--TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYI 269 S+ + PE + + D WS G ++ E+ + +P + Sbjct: 210 IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 269 Query: 270 DQWNKVIEQLGTPCP-----EFMKKLQPTVRNYVENRPKYAGL 307 + V P + + ++ E+RP +A + Sbjct: 270 EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAII 312 >5WNO-A nrPDB Length = 330 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 100/257 (38%), Gaps = 19/257 (7%) Query: 65 QNLKPIGSGAQGIVCAA-----YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 + K +G+GA G V A + VAIK +Q+ E M + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQT---DQSQTDEMLEEATNMFRLR 81 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 179 H N++ ++ L+ + L N ++ + L YQ+ G+++ Sbjct: 82 HDNLLKIIGFCMHDDGLKIVTIYRPLGNL--QNFLKLHKENLGAREQVLYCYQIASGMQY 139 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA---GTSFMMTPYVVTRYYRAPEVIL 236 L ++HRDL N++VK ++I DFGL++ S + V + A E+ Sbjct: 140 LEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 237 GMGYKENVDIWSVGCIMGEMVR-HKILFPG--RDYIDQWNKVIEQLGTPC---PEFMKKL 290 Y D+W+ G E++ + + G D I + K +L P + ++L Sbjct: 200 KHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQEL 259 Query: 291 QPTVRNYVENRPKYAGL 307 ++RP + L Sbjct: 260 LRCWMADPKSRPGFEIL 276 >5O0Y-A nrPDB Length = 579 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 111/310 (35%), Gaps = 66/310 (21%) Query: 75 QGIVCAAYDAVLDRNVAIKK--LSRPFQNQT---HAKRAYRELVLMKCVNHKNIISLLNV 129 V A+D R VA+K L++ ++++ + K A RE + K ++H I+ L + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 130 FTPQKTLEEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQMLCGIKHLHSAG-- 184 F+ V+E + N + + + ++ Q++ +K+L+ Sbjct: 357 FSLDT-----DSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 411 Query: 185 IIHRDLKPSNIVVKSD---CTLKILDFGLARTAGTS--------FMMTPYVVTRYYRAPE 233 IIH DLKP NI++ + +KI DFGL++ + + T +Y PE Sbjct: 412 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 471 Query: 234 VI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 VD+WSVG I + + + F G + Q + Sbjct: 472 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQDILQENTI---------- 520 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 K + FP + +A+ + + L RI Sbjct: 521 ------------LKATEVQFPPK-------------PVVTPEAKAFIRRCLAYRKEDRID 555 Query: 350 VDDALQHPYI 359 V PY+ Sbjct: 556 VQQLACDPYL 565 >4X7Q-B nrPDB Length = 312 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 120/327 (36%), Gaps = 72/327 (22%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR----PFQNQTHAKRAYRELVLMKCV 118 Y+ +G G G V A + VAIK + R + + + E+ L+ V Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 119 N----HKNIISLLNVFTPQKTLEEFQDVYLVME--LMDANLCQVI--QMELDHERMSYLL 170 H +I LL+ F Q+ LV+E L +L I + L Sbjct: 92 GAGGGHPGVIRLLDWFETQEGF------MLVLERPLPAQDLFDYITEKGPLGEGPSRCFF 145 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRYY 229 Q++ I+H HS G++HRD+K NI++ K++DFG + T + TR Y Sbjct: 146 GQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVY 204 Query: 230 RAPEVILGMGYKE-NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK 288 PE I Y +WS+G ++ +MV I F ++ +++E Sbjct: 205 SPPEWISRHQYHALPATVWSLGILLYDMVCGDIPF------ERDQEILE----------- 247 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI 348 A L FP + L+ + L P+ R Sbjct: 248 ----------------AELHFPA---------------HVSPDCCALIRRCLAPKPSSRP 276 Query: 349 SVDDALQHPYINVWYDPAEVEAPPPQI 375 S+++ L P++ PAE P Sbjct: 277 SLEEILLDPWMQ---TPAEDVPLNPSK 300 >4C59-A nrPDB Length = 340 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 68/339 (20%), Positives = 127/339 (37%), Gaps = 78/339 (23%) Query: 41 KSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ 100 + + D +VE+G+ R + + + G V A D R A+K+L + Sbjct: 12 RDQSDFVGQTVELGEL------RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEE 65 Query: 101 NQTHAKRAYRELVLMKCVN-HKNIISLLNV--FTPQKTLEEFQDVYLVMELMDANLCQVI 157 + A +E+ MK ++ H NI+ + +++ + L+ EL L + + Sbjct: 66 EKNRA--IIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFL 123 Query: 158 QM-----ELDHERMSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGL 210 + L + + + YQ ++H+H IIHRDLK N+++ + T+K+ DFG Sbjct: 124 KKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGS 183 Query: 211 ARTAGTSFMMT-------------PYVVTRYYRAPEVI---LGMGYKENVDIWSVGCIMG 254 A T + T YR PE+I E DIW++GCI+ Sbjct: 184 ATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILY 243 Query: 255 EMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFP 314 + + F + + R + P Sbjct: 244 LLCFRQHPFE-------------------------------DGAKLRIVNGKYSIP---- 268 Query: 315 DSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 P D+++ + L+ ML ++P +R+S+ + Sbjct: 269 ----PHDTQYTVFHS-----LIRAMLQVNPEERLSIAEV 298 >3QD2-B nrPDB Length = 332 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 64/268 (23%), Positives = 104/268 (38%), Gaps = 71/268 (26%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 L ++ ++ +G G G+V A + V D N AIK++ P + + ++ RE+ + + H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNR-ELAREKVMREVKALAKLEH 63 Query: 121 KNIISLLNVFT---PQKTLEEFQDV----------------------------------- 142 I+ N + P+K EE ++ Sbjct: 64 PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNT 123 Query: 143 -------------YLVMELMDA-NLCQVIQMELD-----HERMSYLLYQMLCGIKHLHSA 183 Y+ M+L NL + H ++ Q+ ++ LHS Sbjct: 124 VGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM-------------MTPYVVTRYYR 230 G++HRDLKPSNI D +K+ DFGL T V T+ Y Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVR 258 +PE I G Y VDI+S+G I+ E++ Sbjct: 244 SPEQIHGNNYSHKVDIFSLGLILFELLY 271 >4F0G-A nrPDB Length = 287 Score = 170 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 106/269 (39%), Gaps = 36/269 (13%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA-----KRAYRELVLMKCVN 119 + K IG G G+V VAIK L + RE+ +M +N Sbjct: 22 EYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLN 81 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME---LDHERMSYLLYQMLC 175 H NI+ L + +VME + +L + + + L+ + Sbjct: 82 HPNIVKLYGLMHNPPR--------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIAL 133 Query: 176 GIKHLHSAG--IIHRDLKPSNIV---VKSDCTL--KILDFGLARTAGTSFMMTPYVVTRY 228 GI+++ + I+HRDL+ NI + + + K+ DFGL++ + S ++ + Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS--VSGLLGNFQ 191 Query: 229 YRAPEVI--LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDY--IDQWNKVIEQ-----L 279 + APE I Y E D +S I+ ++ + F Y I N + E+ + Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTI 251 Query: 280 GTPCPEFMKKLQPTVRN-YVENRPKYAGL 307 CP ++ + + + RP ++ + Sbjct: 252 PEDCPPRLRNVIELCWSGDPKKRPHFSYI 280 >5LPZ-A nrPDB Length = 332 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 56/221 (25%), Positives = 89/221 (40%), Gaps = 22/221 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + N IGSG G V A VAIKKL Q + E+ + + H+N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIH-VSGQGDRE-FMAEMETIGKIKHRNL 75 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM------ELDHERMSYLLYQMLCG 176 + LL + + LV E M +L V+ +L+ + G Sbjct: 76 VPLLGYC------KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 177 IKHLH---SAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYR 230 + LH S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 PE D++S G ++ E++ K D+ D Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >5LPV-A nrPDB Length = 296 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 56/221 (25%), Positives = 89/221 (40%), Gaps = 22/221 (9%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 + N IGSG G V A VAIKKL Q + E+ + + H+N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIH-VSGQGDRE-FMAEMETIGKIKHRNL 75 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM------ELDHERMSYLLYQMLCG 176 + LL + + LV E M +L V+ +L+ + G Sbjct: 76 VPLLGYC------KVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 177 IKHLH---SAGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYR 230 + LH S IIHRD+K SN+++ + ++ DFG+AR T ++ T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 PE D++S G ++ E++ K D+ D Sbjct: 190 PPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN 230 >2RIO-A nrPDB Length = 434 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 125/328 (38%), Gaps = 85/328 (25%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM-KCVNHKNIISL 126 K +G G+ G V + R VA+K++ F A E+ L+ + +H N+I Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDF-----CDIALMEIKLLTESDDHPNVIRY 74 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMEL---------DHERMSYLLYQMLCGI 177 T + L Y+ +EL + NL +++ + LL Q+ G+ Sbjct: 75 YCSETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 178 KHLHSAGIIHRDLKPSNIVVK-------------SDCTLKILDFGLARTAGTSFM----- 219 HLHS IIHRDLKP NI+V + + I DFGL + + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 220 MTPYVVTRYYRAPEVILG-------MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQ 271 + T +RAPE++ ++DI+S+GC+ ++ K F G Y + Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF-GDKYSRE 247 Query: 272 WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQ 331 N + SL H++ ++ Sbjct: 248 SNIIRGIF------------------------------------SLDEMKCLHDRSLIAE 271 Query: 332 ARDLLSKMLVIDPAKRISVDDALQHPYI 359 A DL+S+M+ DP KR + L+HP Sbjct: 272 ATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >4LQP-A nrPDB Length = 508 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 43/210 (20%), Positives = 86/210 (40%), Gaps = 17/210 (8%) Query: 25 DKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVL-------KRYQNLKPIGSGAQGI 77 +++V++ +N S+ + Q S+ +S F L + + +K IG GA G Sbjct: 58 ERRVELETELTSHNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGE 117 Query: 78 VCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTL 136 V + A+K L + + E ++ + ++SL F Sbjct: 118 VRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSF------ 171 Query: 137 EEFQDVYLVMELMDANLCQVIQME---LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPS 193 ++ Q +YL+ME + + + + + + + + I+ +H G IHR +KP Sbjct: 172 QDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPD 231 Query: 194 NIVVKSDCTLKILDFGLARTAGTSFMMTPY 223 NI++ +K+ DFGL+ + Y Sbjct: 232 NILIDIRGHIKLSDFGLSTGFHKTHDSNYY 261 Score = 97.4 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 74/213 (34%), Gaps = 50/213 (23%) Query: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 V T Y APE+ L GY + D WS+G IM E + F + + K++ Sbjct: 322 STVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN---- 377 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 F + LQ FPD + + +A DL+ ++L Sbjct: 378 ----FEQTLQ---------------------FPDDIH---------ISYEAEDLIRRLLT 403 Query: 342 IDPAKRI----SVDDALQHPYIN--VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIY 395 +R+ D+ HP+ W +VEAP D R +E Sbjct: 404 H-ADQRLGRHGGADEIKSHPFFRGVDWNTIRQVEAPYIPKLSSITDTRFFPTDEL----- 457 Query: 396 KEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLP 428 + V +S + + Q + G + E LP Sbjct: 458 ENVPDSPAMAQAAKQREQMTKQGGSAPVKEDLP 490 >4IDT-A nrPDB Length = 356 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 54/204 (26%), Positives = 86/204 (42%), Gaps = 23/204 (11%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G G+ G V D A+KK+ EL+ + I+ L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE-------ELMACAGLTSPRIVPLYGA 134 Query: 130 FTPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGII 186 E V + MEL++ L Q+++ + L +R Y L Q L G+++LHS I+ Sbjct: 135 VR------EGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRIL 188 Query: 187 HRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYV------VTRYYRAPEVILGMG 239 H D+K N+++ SD + DFG A + + T + APEV+LG Sbjct: 189 HGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRS 248 Query: 240 YKENVDIWSVGCIMGEMVRHKILF 263 VD+WS C+M M+ + Sbjct: 249 CDAKVDVWSSCCMMLHMLNGCHPW 272 >4PL5-B nrPDB Length = 435 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 90/402 (22%), Positives = 149/402 (37%), Gaps = 86/402 (21%) Query: 69 PIGSGAQGI-VCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISL 126 +G GA+G V +R+VA+K++ + RE+ L++ + H N+I Sbjct: 34 VLGHGAEGTIVYKGM--FDNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 86 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIKHLHS 182 T + + Q Y+ +EL A L + ++ + L E ++ LL+Q G+ HLHS Sbjct: 87 F--CTEK----DRQFQYIAIELCAATLQEYVEQKDFAHLGLEPIT-LLHQTTSGLAHLHS 139 Query: 183 AGIIHRDLKPSNIVV---KSDCTLK--ILDFGLARTAGTS----FMMTPYVVTRYYRAPE 233 I+HRDLKP NI++ + +K I DFGL + + T + APE Sbjct: 140 LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 199 Query: 234 VILG---MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 ++ VDI+S GC+ ++ F G+ Q N ++ C Sbjct: 200 MLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDC------ 252 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 +K + AR+L+ KM+ +DP +R S Sbjct: 253 --------------------------------FHSDKHEDVIARELIEKMIAMDPQQRPS 280 Query: 350 VDDALQHP----------YINVWYDPAEVEAPP-PQIYDKQLDEREHTIEEWKELI---Y 395 L+HP + D E EA P + + R +W+E I Sbjct: 281 AKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVKMDWRENITVPL 340 Query: 396 KEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDIS 437 + + K G V+ + LP S Sbjct: 341 QTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPVEVQETLGS 382 >2PMN-X nrPDB Length = 348 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 123/330 (37%), Gaps = 60/330 (18%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH---------------A 105 + Y+ ++ + G + ++ A+KK + + Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 106 KRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----------LC 154 EL ++ + ++ T + + + +VY++ E M+ + L Sbjct: 88 DDFKNELQIITDIKNE------YCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLD 141 Query: 155 QVIQMELDHERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLKILDFGLART 213 + + + + ++ +L ++H I HRD+KPSNI++ + +K+ DFG + Sbjct: 142 KNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEY 201 Query: 214 AGTSFMMTPYVVTRYYRAPEVILGM-GY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 + T + PE Y VDIWS+G + M + + F Sbjct: 202 MVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFS------- 253 Query: 272 WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQ 331 L E ++ Y +R + L+P + + +N L +++ Sbjct: 254 -------LKISLVELFNNIRTKNIEYPLDRNHF-------LYPLTNKKSTCSNNFL-SNE 298 Query: 332 ARDLLSKMLVIDPAKRISVDDALQHPYINV 361 D L L +PA+RI+ +DAL+H ++ Sbjct: 299 DIDFLKLFLRKNPAERITSEDALKHEWLAD 328 >6HV0-A nrPDB Length = 416 Score = 167 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 90/402 (22%), Positives = 147/402 (36%), Gaps = 86/402 (21%) Query: 69 PIGSGAQGI-VCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISL 126 +G GA+G V +R+VA+K++ + RE+ L++ + H N+I Sbjct: 15 VLGHGAEGTIVYRGM--FDNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 67 Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIKHLHS 182 T + + Q Y+ +EL A L + ++ + L E ++ LL Q G+ HLHS Sbjct: 68 F--CTEK----DRQFQYIAIELCAATLQEYVEQKDFAHLGLEPIT-LLQQTTSGLAHLHS 120 Query: 183 AGIIHRDLKPSNIVV---KSDCTLK--ILDFGLARTAGTS----FMMTPYVVTRYYRAPE 233 I+HRDLKP NI++ + +K I DFGL + + T + APE Sbjct: 121 LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 180 Query: 234 VILG---MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 ++ VDI+S GC+ ++ F G+ Q N ++ C Sbjct: 181 MLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDC------ 233 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 L P E AR+L+ KM+ +DP KR S Sbjct: 234 ---------------------------LHPEKHEDVI-----ARELIEKMIAMDPQKRPS 261 Query: 350 VDDALQHPYI-----------NVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELI---Y 395 L+HP+ +V + P + + R +W+E I Sbjct: 262 AKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPL 321 Query: 396 KEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDIS 437 + + K G V+ + LP S Sbjct: 322 QTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGS 363 >4G3E-A nrPDB Length = 352 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 55/203 (27%), Positives = 85/203 (41%), Gaps = 23/203 (11%) Query: 71 GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVF 130 G G+ G V D A+KK+ ELV ++ I+ L Sbjct: 83 GRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-------VEELVACAGLSSPRIVPLYGAV 135 Query: 131 TPQKTLEEFQDVYLVMELMDAN-LCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIH 187 E V + MEL++ L Q+I+ L +R Y L Q L G+++LH+ I+H Sbjct: 136 R------EGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILH 189 Query: 188 RDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTPYV------VTRYYRAPEVILGMGY 240 D+K N+++ SD + DFG A + + T + APEV++G Sbjct: 190 GDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPC 249 Query: 241 KENVDIWSVGCIMGEMVRHKILF 263 VDIWS C+M M+ + Sbjct: 250 DAKVDIWSSCCMMLHMLNGCHPW 272 >3LMG-A nrPDB Length = 344 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 101/260 (38%), Gaps = 23/260 (8%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY---RELVLMKCVNHK 121 + LK +GSG G V ++ I + ++++ + ++ + ++H Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHA 93 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME---LDHERMSYLLYQMLCGI 177 +I+ LL + + LV + + +L ++ L + + Q+ G+ Sbjct: 94 HIVRLLGLC-------PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGM 146 Query: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM---MTPYVVTRYYRAPEV 234 +L G++HR+L N+++KS +++ DFG+A + + A E Sbjct: 147 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 235 ILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQ--WNKVIEQLGTP--CPEFMKK 289 I Y D+WS G + E++ + G + + E+L P C + Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 266 Query: 290 LQPTVRNYVEN-RPKYAGLT 308 + EN RP + L Sbjct: 267 VMVKCWMIDENIRPTFKELA 286 >3HNG-A nrPDB Length = 360 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 68/328 (20%), Positives = 111/328 (33%), Gaps = 82/328 (25%) Query: 61 LKRYQNLKPIGSGAQGIVCAA-----YDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 +R + K +G GA G V A + R VA+K L + + K EL ++ Sbjct: 26 RERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKML-KEGATASEYKALMTELKIL 84 Query: 116 KCV-NHKN-----------------IISLLNVFTPQKTLEEFQDVYLV-------ME--- 147 + +H N I+ L+ +D++ + ME Sbjct: 85 THIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKK 144 Query: 148 -LMDANLCQVIQMELD-------------------------------------HERMSYL 169 M+ L Q + LD E + Sbjct: 145 EKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISY 204 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTR-- 227 +Q+ G++ L S IHRDL NI++ + +KI DFGLAR + TR Sbjct: 205 SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLP 264 Query: 228 -YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQW------NKVIEQL 279 + APE I Y D+WS G ++ E+ +PG + + + Sbjct: 265 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 324 Query: 280 GTPCPEFMKKLQPTVRNYVENRPKYAGL 307 PE + + + RP++A L Sbjct: 325 EYSTPEIYQIMLDCWHRDPKERPRFAEL 352 >6J5U-C nrPDB Length = 426 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 75/387 (19%), Positives = 132/387 (34%), Gaps = 71/387 (18%) Query: 62 KRYQNLKPIGSGAQGIVCAAY---------DAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 K ++ +G G G V + VA+K+L +P Q H K E+ Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQL-KPEGFQGH-KEWLTEV 141 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-----DANLCQVIQMELDHERMS 167 + ++H N++ L+ E ++ LV E M + +L + L Sbjct: 142 NYLGQLSHPNLVLLVGYCA------EGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRM 195 Query: 168 YLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS---FMMTP 222 + G+ LH A +I+RD K +NI++ +D K+ DFGLA+ T + T Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTK 255 Query: 223 YVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP 282 + T Y APE + D++S G ++ E++ + + ++++ + Sbjct: 256 VIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYS----LVDWA 311 Query: 283 CPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVI 342 P K KLF ++ + A A +L + L Sbjct: 312 TPYLGDK--------------------RKLFRIMDTKLGGQYPQKGAFTAANLALQCLNP 351 Query: 343 DPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSE 402 D R + + L Q+ +HT E + VM Sbjct: 352 DAKLRPKMSEVL---------------VTLEQLESVAKPGTKHTQMESPRFHHSSVMQ-- 394 Query: 403 EKTKNGVVKGQPSPSGAAVNSSESLPP 429 K+ V P + LP Sbjct: 395 ---KSPVRYSHDRPLLHMTPGASPLPS 418 >4JLC-A nrPDB Length = 657 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 56/233 (24%), Positives = 88/233 (37%), Gaps = 23/233 (9%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V A+K + RE ++K +NHKNI+ L + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFN-NISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 74 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-----LDHERMSYLLYQMLCGIKHLHSA 183 T + L+ME +L V++ L +L ++ G+ HL Sbjct: 75 EEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 184 GIIHRDLKPSNIV--VKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 GI+HRD+KP NI+ + D K+ DFG AR T Y P++ Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 190 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y VD+WSVG + F + + +V+ ++ T P Sbjct: 191 LRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 243 >2BUJ-A nrPDB Length = 317 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 99/239 (41%), Gaps = 27/239 (11%) Query: 45 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 +N ++ G K Y ++ +G G V A+K++ Q Sbjct: 15 ENLYFQ---GHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQD 69 Query: 105 AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME--- 160 + A RE + + NH NI+ L+ ++ + +L++ L I+ Sbjct: 70 REEAQREADMHRLFNHPNILRLVAYCLRER--GAKHEAWLLLPFFKRGTLWNEIERLKDK 127 Query: 161 ---LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL------- 210 L +++ +LL + G++ +H+ G HRDLKP+NI++ + ++D G Sbjct: 128 GNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIH 187 Query: 211 ---ARTAGTSFMMTPYVVTRYYRAPEVILGMGY---KENVDIWSVGCIMGEMVRHKILF 263 +R A T T YRAPE+ + E D+WS+GC++ M+ + + Sbjct: 188 VEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 >3MDY-A nrPDB Length = 337 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 122/317 (38%), Gaps = 52/317 (16%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 T+ K+ Q +K IG G G V VA+K + +RE + + Sbjct: 32 QRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEAS-----WFRETEIYQ 84 Query: 117 C--VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-LDHERMSYLLYQ 172 + H+NI+ + K + +YL+ + + +L ++ LD + M L Y Sbjct: 85 TVLMRHENILGFIAA--DIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYS 142 Query: 173 MLCGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLA-----RTAGTSFM 219 + G+ HLH I HRDLK NI+VK + T I D GLA T Sbjct: 143 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 220 MTPYVVTRYYRAPEVI---LGMGYKEN---VDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 V T+ Y PEV+ L + ++ D++S G I+ E+ R + Sbjct: 203 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCV----------SG 252 Query: 274 KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQAR 333 ++E+ P L P+ +Y + R FP+ + K Sbjct: 253 GIVEEYQLP----YHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGK----- 303 Query: 334 DLLSKMLVIDPAKRISV 350 L+++ +PA R++ Sbjct: 304 -LMTECWAHNPASRLTA 319 >4Y83-A nrPDB Length = 332 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 109/301 (36%), Gaps = 60/301 (19%) Query: 67 LKPIGS-----GAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + IGS GA G V A D + +A K + + + + C H+ Sbjct: 73 YRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD-------VEIQACFRHE 125 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCGIK 178 NI L + V+L ME + + + ++ + + ++ +L G+ Sbjct: 126 NIAELYGAVL------WGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLD 179 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS-FMMTPYVVTRYYRAPEVILG 237 LHS +IH D+KPSNIV S + ++DFGL+ + T Y +PEVIL Sbjct: 180 FLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC 238 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 G+ DI+S+G + M + V+ Y Sbjct: 239 RGHSTKADIYSLGATLIHMQTGTPPW------------------------------VKRY 268 Query: 298 VEN-RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQH 356 + P Y + + P D + R+L+ L +P R D L+H Sbjct: 269 PRSAYPSYLYIIHKQAPPLEDIADDC------SPGMRELIEASLERNPNHRPRAADLLKH 322 Query: 357 P 357 Sbjct: 323 E 323 >3Q4U-A nrPDB Length = 301 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 72/322 (22%), Positives = 116/322 (36%), Gaps = 58/322 (18%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 TV + L+ +G G G V NVA+K S K +RE L Sbjct: 1 SMQRTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFS-----SRDEKSWFRETEL 53 Query: 115 MK--CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQ-MELDHERMSYLL 170 + H+NI+ + + + ++L+ + +L +Q LD ++ Sbjct: 54 YNTVMLRHENILGFIA--SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIV 111 Query: 171 YQMLCGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-- 220 + G+ HLH I HRDLK NI+VK + I D GLA S Sbjct: 112 LSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLD 171 Query: 221 ---TPYVVTRYYRAPEVILGM-------GYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 P V T+ Y APEV+ Y + VDIW+ G ++ E+ R + Sbjct: 172 VGNNPRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMV--------- 221 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSL--FPADSEHNKLK 328 N ++E P + V N P + + P + Sbjct: 222 -SNGIVEDYKPP-----------FYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTL 269 Query: 329 ASQARDLLSKMLVIDPAKRISV 350 S A+ L+ + +P+ R++ Sbjct: 270 TSLAK-LMKECWYQNPSARLTA 290 >4EUU-A nrPDB Length = 319 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 88/233 (37%), Gaps = 23/233 (9%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V AIK + RE ++K +NHKNI+ L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 75 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-----LDHERMSYLLYQMLCGIKHLHSA 183 T + L+ME +L V++ L +L ++ G+ HL Sbjct: 76 EEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 184 GIIHRDLKPSNIV--VKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 GI+HR++KP NI+ + D K+ DFG AR T Y P++ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y VD+WS+G + F + + +V+ ++ T P Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >5WNL-A nrPDB Length = 342 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 67/371 (18%), Positives = 122/371 (32%), Gaps = 67/371 (18%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + +GSG G V +AIK + E M+ + I+ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 128 NVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-LDHERMSYLLYQMLCGIKHLH--SA 183 + V LVME M+ +L +++ E L + ++++ G+ LH S Sbjct: 86 GICQEP--------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAG----TSFMMTPYVVTRYYRAPEVILGMG 239 ++H +LKP+NI++ + +KI DFGLA+ G M T Y PE I Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 240 --YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 + D++S ++ ++ K F D + + +++ + PE Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPFA--DEKNILHIMMKVVKGHRPEL----------- 244 Query: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHP 357 P + L+ + DP R + Sbjct: 245 ---------------------PPICRPRPRACASLIGLMQRCWHADPQVRPT-------- 275 Query: 358 YINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPS 417 E P D+++ + H E L E + + + + P Sbjct: 276 -FQEITSETEDLCEKP---DEEVKDLAHEPGEKSSL---ESKSEARPESSRLKRASAPPF 328 Query: 418 GAAVNSSESLP 428 + SE L Sbjct: 329 DNDCSLSELLS 339 >2WTK-B nrPDB Length = 373 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 61/325 (18%), Positives = 112/325 (34%), Gaps = 39/325 (12%) Query: 64 YQNLKPIGSGAQG---IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Y+ L IG G V A V +++++ + EL + K NH Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLC 175 NI+ F ++++V M +C ++ ++Y+L +L Sbjct: 70 PNIVPYRATFIAD------NELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLK 123 Query: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL----------ARTAGTSFMMTPYVV 225 + ++H G +HR +K S+I++ D + + GL R V Sbjct: 124 ALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVK 181 Query: 226 TRYYRAPEVILG--MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 + +PEV+ GY DI+SVG E+ + F +E+L Sbjct: 182 VLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQML---LEKLNGTV 238 Query: 284 PEFM-------KKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLL 336 P + ++L + V N LT P + +++ + + Sbjct: 239 PCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFV 298 Query: 337 SKMLVIDPAKRISVDDALQHPYINV 361 + L +P R S L H + Sbjct: 299 EQCLQRNPDARPSASTLLNHSFFKQ 323 >4EUT-A nrPDB Length = 396 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 88/233 (37%), Gaps = 23/233 (9%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V AIK + RE ++K +NHKNI+ L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 75 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-----LDHERMSYLLYQMLCGIKHLHSA 183 T + L+ME +L V++ L +L ++ G+ HL Sbjct: 76 EEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 184 GIIHRDLKPSNIV--VKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 GI+HR++KP NI+ + D K+ DFG AR T Y P++ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y VD+WS+G + F + + +V+ ++ T P Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >5TE0-A nrPDB Length = 347 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 60/329 (18%), Positives = 107/329 (32%), Gaps = 73/329 (22%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN-HKNI 123 + + G IV A+K++ N+ + RE+ +M+ ++ HKNI Sbjct: 22 TVDEVLAEGGFAIVFLVR-TSNGMKCALKRMF--VNNEHDLQVCKREIQIMRDLSGHKNI 78 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELDHERMSYLLYQMLCGIK 178 + ++ + + +V ++M+ + Q +Q + + + Sbjct: 79 VGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVA 138 Query: 179 HLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPY---------VVTR 227 LH IIHRDLK NI++ + DFG A + T Sbjct: 139 RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 228 YYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 YRAPE++ G DIW++GC++ ++ + F G + + Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQVAICD----------- 246 Query: 285 EFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 T P N + L+ ML DP Sbjct: 247 --------------------GNFTIPD-------------NSRYSQDMHCLIRYMLEPDP 273 Query: 345 AKRISVDDALQHPYINVWYDPAEVEAPPP 373 KR + Y + + + E P P Sbjct: 274 DKRPDIYQV---SYFS--FKLLKKECPIP 297 >6O8B-A nrPDB Length = 665 Score = 160 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 88/233 (37%), Gaps = 23/233 (9%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V AIK + RE ++K +NHKNI+ L + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 81 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-----LDHERMSYLLYQMLCGIKHLHSA 183 T + L+ME +L V++ L +L ++ G+ HL Sbjct: 82 EEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 137 Query: 184 GIIHRDLKPSNIV--VKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 GI+HR++KP NI+ + D K+ DFG AR T Y P++ Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAV 197 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y VD+WS+G + F + + +V+ ++ T P Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 >6NT9-A nrPDB Length = 742 Score = 160 bits (406), Expect = 9e-40, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 88/233 (37%), Gaps = 23/233 (9%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV 129 +G GA V AIK + RE ++K +NHKNI+ L + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFN-NISFLRPVDVQMREFEVLKKLNHKNIVKLFAI 73 Query: 130 FTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-----LDHERMSYLLYQMLCGIKHLHSA 183 T + L+ME +L V++ L +L ++ G+ HL Sbjct: 74 EEETTT----RHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 Query: 184 GIIHRDLKPSNIV--VKSDCT--LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL--- 236 GI+HR++KP NI+ + D K+ DFG AR T Y P++ Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 Query: 237 -----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 Y VD+WS+G + F + + +V+ ++ T P Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 >3G2F-A nrPDB Length = 336 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 76/322 (23%), Positives = 121/322 (37%), Gaps = 57/322 (17%) Query: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC--V 118 L + L+ IG G G V ++ +R VA+K S + + E + + + Sbjct: 12 LDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFS-----FANRQNFINEKNIYRVPLM 64 Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMEL-DHERMSYLLYQMLCG 176 H NI + V + T + + LVME + +LC+ + + D L + + G Sbjct: 65 EHDNIARFI-VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRG 123 Query: 177 IKHLH---------SAGIIHRDLKPSNIVVKSDCTLKILDFGLA---------RTAGTSF 218 + +LH I HRDL N++VK+D T I DFGL+ R Sbjct: 124 LAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDN 183 Query: 219 MMTPYVVTRYYRAPEVILG-------MGYKENVDIWSVGCIMGEMVRHKI-LFPGRDYID 270 V T Y APEV+ G + VD++++G I E+ LFPG + Sbjct: 184 AAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPE 243 Query: 271 -QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA 329 Q E P E M+ L + RPK+ P + N L Sbjct: 244 YQMAFQTEVGNHPTFEDMQVLVSREKQ----RPKF--------------PEAWKENSLAV 285 Query: 330 SQARDLLSKMLVIDPAKRISVD 351 ++ + D R++ Sbjct: 286 RSLKETIEDCWDQDAEARLTAQ 307 >3UIM-A nrPDB Length = 326 Score = 157 bits (398), Expect = 8e-39, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 86/214 (40%), Gaps = 20/214 (9%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 121 + N +G G G V VA+K+L + + Q + E+ ++ H+ Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRL-KEERTQGGELQFQTEVEMISMAVHR 87 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME------LDHERMSYLLYQML 174 N++ L + LV M + ++ ++ LD + + Sbjct: 88 NLLRLRGFCMTP------TERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSA 141 Query: 175 CGIKHLHSA---GIIHRDLKPSNIVVKSDCTLKILDFGLARTAG--TSFMMTPYVVTRYY 229 G+ +LH IIHRD+K +NI++ + + DFGLA+ + + T T + Sbjct: 142 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGH 201 Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILF 263 APE + E D++ G ++ E++ + F Sbjct: 202 IAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >2QKW-B nrPDB Length = 321 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 67/324 (20%), Positives = 114/324 (35%), Gaps = 43/324 (13%) Query: 40 SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF 99 S V + Y V + D + + IG G G V VA+K R Sbjct: 18 SSYLVPFESYRVPLVDLE-EATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALK--RRTP 73 Query: 100 QNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ- 158 ++ + E+ + H +++SL+ E +Y ME + NL + + Sbjct: 74 ESSQGIEEFETEIETLSFCRHPHLVSLIGFC---DERNEMILIYKYME--NGNLKRHLYG 128 Query: 159 -----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR- 212 M + E+ + G+ +LH+ IIHRD+K NI++ + KI DFG+++ Sbjct: 129 SDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKK 188 Query: 213 --TAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYID 270 + + T T Y PE + E D++S G ++ E++ + Sbjct: 189 GTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCAR---------- 238 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 + P M L N + + P L D + P A Sbjct: 239 ------SAIVQSLPREMVNL-AEWAVESHNNGQLEQIVDPNL-ADKIRPESLRKFGDTAV 290 Query: 331 QARDLLSKMLVIDPAKRISVDDAL 354 K L + R S+ D L Sbjct: 291 -------KCLALSSEDRPSMGDVL 307 >4M66-A nrPDB Length = 325 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 133/316 (42%), Gaps = 48/316 (15%) Query: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117 + + L+ +G G G+V A+ + +VA+K ++ +K+ E+ M Sbjct: 16 LVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVN 67 Query: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME--LDHERMSYLLYQML 174 + ++N++ LL V T + LV M+ +L ++Q E + LL +++ Sbjct: 68 LRNENVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVV 126 Query: 175 CGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLAR-------TAGTSFMMTPYVV 225 G+ +LHS ++HRDLKPSNI++ + K+ DFGL+ +G+ Sbjct: 127 LGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGG 186 Query: 226 TRYYRAPEVIL--GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG--- 280 T Y PE++ + + D++S G ++ ++ + + +D+ + + E + Sbjct: 187 TLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AELVDKTSLIRETVCDRQ 242 Query: 281 --------------TPCPEFMKKLQPTVR-NYVENRPKYAGLTFPKLFPDSLFPADSEHN 325 TP E +K+L + ENRP + + ++ + Sbjct: 243 SRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCE---PKTNEVYNLVKDKV 299 Query: 326 KLKASQARDLLSKMLV 341 S+ + LS+ L Sbjct: 300 DAAVSEVKHYLSQHLE 315 >2H34-A nrPDB Length = 309 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 113/284 (39%), Gaps = 19/284 (6%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVNHKN 122 Y+ + +G G G V A D V +R VA+K +S + R RE + + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKH 179 ++ + + E +Y+ M L++ +L +++ + L R ++ Q+ + Sbjct: 96 VVPIHDF------GEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF--MMTPYVVTRYYRAPEVILG 237 H+AG HRD+KP NI+V +D ++DFG+A + V T YY APE Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSE 209 Query: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC---PEFMKKLQPTV 294 DI+++ C++ E + + G + + + P P + Sbjct: 210 SHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVI 269 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 + P+ +T L + + +A D+L + Sbjct: 270 ARGMAKNPEDRYVTCGDLSAAAHAALATADQ----DRATDILRR 309 >5IKW-A nrPDB Length = 310 Score = 155 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 53/235 (22%), Positives = 89/235 (37%), Gaps = 25/235 (10%) Query: 50 SVEVGDSTFTVLK-RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA 108 S+ VG F V + + + + G V A+K++ N Sbjct: 1 SMSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRM--YVNNMPDLNVC 57 Query: 109 YRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-----LCQVIQMELD 162 RE+ +MK ++ HKNI+ L+ + +V ++ME A + + +Q Sbjct: 58 KREITIMKELSGHKNIVGYLD-CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFT 116 Query: 163 HERMSYLLYQMLCGIKHLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 + + + LH IIHRDLK NI++ + DFG A + Sbjct: 117 EPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQK 176 Query: 221 TPY---------VVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHKILF 263 T YRAPE+I G DIW++GC++ ++ + F Sbjct: 177 DGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF 231 >1PY5-A nrPDB Length = 326 Score = 155 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 64/270 (23%), Positives = 104/270 (38%), Gaps = 35/270 (12%) Query: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116 T+ + + IG G G V VA+K S + +RE + + Sbjct: 24 QRTIARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIFS-----SREERSWFREAEIYQ 76 Query: 117 --CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVI-QMELDHERMSYLLYQ 172 + H+NI+ + K + ++LV + + +L + + + E M L Sbjct: 77 TVMLRHENILGFIAA--DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALS 134 Query: 173 MLCGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-----SFM 219 G+ HLH I HRDLK NI+VK + T I D GLA + Sbjct: 135 TASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIA 194 Query: 220 MTPYVVTRYYRAPEV----ILGMGYK--ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 V T+ Y APEV I ++ + DI+++G + E+ R + G Q Sbjct: 195 PNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLP 253 Query: 274 KVIEQLGTPCPEFMKKL--QPTVRNYVENR 301 P E M+K+ + +R + NR Sbjct: 254 YYDLVPSDPSVEEMRKVVCEQKLRPNIPNR 283 >3MY0-A nrPDB Length = 305 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 69/319 (21%), Positives = 122/319 (38%), Gaps = 53/319 (16%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 TV ++ ++ +G G G V +VA+K S + +RE + Sbjct: 1 SMQRTVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFS-----SRDEQSWFRETEI 53 Query: 115 MKC--VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQME-LDHERMSYLL 170 + H NI+ + + + ++L+ + +L +Q + L+ L Sbjct: 54 YNTVLLRHDNILGFIA--SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLA 111 Query: 171 YQMLCGIKHLH--------SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-- 220 CG+ HLH I HRD K N++VKS+ I D GLA Sbjct: 112 VSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLD 171 Query: 221 ---TPYVVTRYYRAPEVI-------LGMGYKENVDIWSVGCIMGEMVR----------HK 260 P V T+ Y APEV+ YK DIW+ G ++ E+ R ++ Sbjct: 172 IGNNPRVGTKRYMAPEVLDEQIRTDCFESYKW-TDIWAFGLVLWEIARRTIVNGIVEDYR 230 Query: 261 ILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPA 320 F D + ++++ + + PT+ N + P +GL ++ + +P Sbjct: 231 PPFYDVVPNDPSFEDMKKVVC-----VDQQTPTIPNRLAADPVLSGLA--QMMRECWYPN 283 Query: 321 DSEHNKLKASQARDLLSKM 339 S +L A + + L K+ Sbjct: 284 PS--ARLTALRIKKTLQKI 300 >5XD6-A nrPDB Length = 305 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 47/226 (20%), Positives = 85/226 (37%), Gaps = 28/226 (12%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 D + Y + IG G+ G V + AIKKL Q + ++ + Sbjct: 15 DELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSM 70 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQME-----------LD 162 + + +N+++LL L E + +L ++ L Sbjct: 71 VSRLRQENVVALLGYCVDGPLR------VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLS 124 Query: 163 HERMSYLLYQMLCGIKHLHSA---GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT--- 216 + + G+++LH +IHRD+K SN+++ D KI DF L+ A Sbjct: 125 WHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAA 184 Query: 217 SFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIL 262 T + T Y APE + D++S G ++ E++ + Sbjct: 185 RLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >3SOC-A nrPDB Length = 322 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 110/269 (40%), Gaps = 33/269 (12%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 Q L+ G G V A +L+ VA+K P Q++ + Y E+ + + H+NI+ Sbjct: 27 QLLEVKARGRFGCVWKAQ--LLNEYVAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENIL 81 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMEL-DHERMSYLLYQMLCGIKHLHS 182 + +++ D++L+ + +L ++ + + ++ M G+ +LH Sbjct: 82 QFIGAEKRGTSVD--VDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHE 139 Query: 183 ----------AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM---MTPYVVTRYY 229 I HRD+K N+++K++ T I DFGLA V TR Y Sbjct: 140 DIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 199 Query: 230 RAPEVILG-----MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCP 284 APEV+ G +D++++G ++ E+ G E P Sbjct: 200 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 259 Query: 285 EFM------KKLQPTVRNYVENRPKYAGL 307 E M KK +P +R+Y + A L Sbjct: 260 EDMQEVVVHKKKRPVLRDYWQKHAGMAML 288 >4F9B-A nrPDB Length = 361 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 126/346 (36%), Gaps = 58/346 (16%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVL---DRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 ++ IG G V A + + +A+K L +H R EL + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLI----PTSHPIRIAAELQCLTVAGG 78 Query: 121 K-NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 179 + N++ + F V + M ++ I L + + + + +K Sbjct: 79 QDNVMGVKYCFRKN------DHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKR 132 Query: 180 LHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTAGTS--------------------- 217 +H GI+HRD+KPSN + ++DFGLA+ + Sbjct: 133 IHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 218 --------FMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVRHKILFP-GRD 267 + P T +RAPEV+ +D+WS G I ++ + F D Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASD 252 Query: 268 YIDQWNKVIEQLGT-----------PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDS 316 + +++ G+ K++ + R + + PKL D Sbjct: 253 DLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDI 312 Query: 317 LFPADS-EHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINV 361 A + E +A DLL K+L ++PA RI+ ++AL HP+ Sbjct: 313 QGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >5AR8-A nrPDB Length = 326 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 116/312 (37%), Gaps = 50/312 (16%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIKKL-SRPFQNQTHAKRAYRELVLMKCVNHKNII 124 +L+ + GA G V +A A VA+K L + K RE ++ I+ Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYIL 95 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQMELDHERMSY-----LLYQMLCGIK 178 +L + E + + +V E M + +L +++ + ++ +++ +L+++ G+ Sbjct: 96 PILGIC------NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVN 149 Query: 179 HLHSAG--IIHRDLKPSNIVVKSDCTLKILDFGLART------AGTSFMMTPYVVTRYYR 230 +LH+ ++H DLK NI++ ++ +KI DFGL++ S P T Y Sbjct: 150 YLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYM 209 Query: 231 APEVILGMGYKENV---DIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM 287 PE DI+S I E++ K F Q + Q Sbjct: 210 PPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQ--------- 260 Query: 288 KKLQPTVRNYVENRPKYAGLTFPKLFPD--SLFPADSEHNKLKASQARDLLSKMLVIDPA 345 +RP + P P + + L ++ ++P Sbjct: 261 -----------GHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPV 309 Query: 346 KR----ISVDDA 353 R I+ +A Sbjct: 310 LRTFEEITFLEA 321 >2Y4I-B nrPDB Length = 319 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 51/316 (16%), Positives = 114/316 (36%), Gaps = 29/316 (9%) Query: 39 MSKSKVDNQFYSVEVGDSTFTVL-KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 +S + + + + ++ + + IG G G V VAI+ + Sbjct: 9 LSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVY---HGRWHGEVAIRLIDI 65 Query: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 157 N+ K RE++ + H+N++ + L + L ++ + Sbjct: 66 ERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLY--SVVRDA 123 Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-- 215 ++ LD + + +++ G+ +LH+ GI+H+DLK N+ + + I DFGL +G Sbjct: 124 KIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVL 182 Query: 216 ----TSFMMTPYVVTRYYRAPEVILG---------MGYKENVDIWSVGCIMGEMVRHKIL 262 + + APE+I + + ++ D++++G I E+ + Sbjct: 183 QAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWP 242 Query: 263 FPGRDYIDQWNKVIEQLGTPC------PEFMKKLQPTVRNYVENRPKYAG-LTFPKLFPD 315 F + ++ + E L E RP + + + P Sbjct: 243 FKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPK 302 Query: 316 SLFPADSEHNKLKASQ 331 + K+++ Sbjct: 303 RNRRLSHPGHFWKSAE 318 >2QLU-A nrPDB Length = 314 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 61/263 (23%), Positives = 109/263 (41%), Gaps = 34/263 (12%) Query: 72 SGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFT 131 G G V A +++ VA+K P Q++ + ++ RE+ + H+N++ + Sbjct: 25 RGRFGCVWKAQ--LMNDFVAVKIF--PLQDK-QSWQSEREIFSTPGMKHENLLQFIAAEK 79 Query: 132 PQKTLEEFQDVYLVMELMD-ANLCQVIQMEL-DHERMSYLLYQMLCGIKHLHS------- 182 LE +++L+ D +L ++ + + ++ M G+ +LH Sbjct: 80 RGSNLE--VELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRG 137 Query: 183 ----AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM---MTPYVVTRYYRAPEVI 235 I HRD K N+++KSD T + DFGLA V TR Y APEV+ Sbjct: 138 EGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVL 197 Query: 236 LG-----MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFM--- 287 G +D++++G ++ E+V G E P E + Sbjct: 198 EGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEV 257 Query: 288 ---KKLQPTVRNYVENRPKYAGL 307 KK++PT++++ P A L Sbjct: 258 VVHKKMRPTIKDHWLKHPGLAQL 280 >4BTF-A nrPDB Length = 469 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 51/237 (21%), Positives = 95/237 (40%), Gaps = 20/237 (8%) Query: 89 NVAIKKLSRPFQNQTHAKRAY--RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM 146 V IK + P R E+ MK + NI+ + + Q + + +VM Sbjct: 220 PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTV--KPPEFSIVM 277 Query: 147 ELMDANLCQVI---QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 E + + + + +L S L+ + G+ LH + +HR++ S+ +V + Sbjct: 278 EYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQV 337 Query: 204 KILDFGLARTAGT-----SFMMTPYVVTRYYRAPEVILG--MGYKENVDIWSVGCIMGEM 256 K+ F L++T + + Y +PE + Y +I+S G ++ E+ Sbjct: 338 KLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEI 397 Query: 257 VRHKILFPGRDYIDQW-----NKVIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGL 307 KI F G D +K E +G CPE ++++ R + RP G+ Sbjct: 398 ATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 454 >4M69-B nrPDB Length = 283 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 51/237 (21%), Positives = 95/237 (40%), Gaps = 20/237 (8%) Query: 89 NVAIKKLSRPFQNQTHAKRAY--RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM 146 V IK + P R E+ MK + NI+ + + Q + + +VM Sbjct: 34 PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTV--KPPEFSIVM 91 Query: 147 ELMDANLCQVI---QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 E + + + + +L S L+ + G+ LH + +HR++ S+ +V + Sbjct: 92 EYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQV 151 Query: 204 KILDFGLARTAGT-----SFMMTPYVVTRYYRAPEVILG--MGYKENVDIWSVGCIMGEM 256 K+ F L++T + + Y +PE + Y +I+S G ++ E+ Sbjct: 152 KLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEI 211 Query: 257 VRHKILFPGRDYIDQW-----NKVIEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGL 307 KI F G D +K E +G CPE ++++ R + RP G+ Sbjct: 212 ATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 268 >5E8V-A nrPDB Length = 316 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 111/317 (35%), Gaps = 59/317 (18%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLD----RNVAIKKLS-RPFQNQTHAKRAYRELVLMKCVN 119 + +G G V A VA+K + + K + ++ + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI----NLK 67 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVI-QMELDHERMSYLLYQMLCGI 177 H+NI+ L ++ E + +L+ NL + + + + E + L + GI Sbjct: 68 HENILQFLTA--EERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGI 125 Query: 178 KHLHSAG---------IIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP-----Y 223 HLHS I+HRDLK SNI+VK+D T + DFGL+ + + Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 185 Query: 224 VVTRYYRAPEVILG-------MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI 276 V T Y APEV+ + + D++S+ ++ EM N V Sbjct: 186 VGTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRC------------NAVG 232 Query: 277 EQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHN--KLKASQARD 334 E P K V P A + + D+ P + Sbjct: 233 EVKDYEPPFGSK---------VREHPCVASMA-DNVLADAGRPEIPSFWLNHQGIQMVCE 282 Query: 335 LLSKMLVIDPAKRISVD 351 L++ DP R++ Sbjct: 283 TLTECWDHDPEARLTAQ 299 >3VHK-A nrPDB Length = 368 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 39/163 (23%), Positives = 68/163 (41%), Gaps = 10/163 (6%) Query: 155 QVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA 214 + + L E + +Q+ G++ L S IHRDL NI++ +KI DFGLAR Sbjct: 191 DLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI 250 Query: 215 ---GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYID 270 + + APE I Y D+WS G ++ E+ +PG + Sbjct: 251 YKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE 310 Query: 271 QWNKVIE---QLGTP---CPEFMKKLQPTVRNYVENRPKYAGL 307 ++ + ++ ++ P PE + + RP ++ L Sbjct: 311 EFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSEL 353 Score = 72.4 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 44/110 (40%), Gaps = 13/110 (11%) Query: 61 LKRYQNLKPIGSGAQGIVCAA----YDAV-LDRNVAIKKLSRPFQNQTHAKRAYRELVLM 115 R + KP+G GA G V A D R VA+K L + H EL ++ Sbjct: 28 RDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR-ALMSELKIL 86 Query: 116 -KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDH 163 +H N+++LL T + +++E NL ++ + + Sbjct: 87 IHIGHHLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKRNE 131 >3SV0-A nrPDB Length = 483 Score = 137 bits (346), Expect = 7e-33, Method: Composition-based stats. Identities = 76/430 (17%), Positives = 146/430 (33%), Gaps = 75/430 (17%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 V +++ + IGSG+ G + + + VAIK +T + E + + + Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL----ENVKTKHPQLLYESKIYRILQ 60 Query: 120 H----KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQ 172 N + V E LVM+L+ +L + +L + + L Q Sbjct: 61 GGTGIPN-VRWFGV--------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 173 MLCGIKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMM--------T 221 M+ ++ +HS +HRD+KP N ++ + + I+DFGLA+ + Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 222 PYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKVIEQ 278 T Y + LG+ D+ S+G ++ +R + + G ++ K+ E+ Sbjct: 172 NLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEK 231 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 E + R Y Y SL D RDL + Sbjct: 232 KVATSIEAL------CRGYPTEFASYFHYC------RSLRFDDKPDYSYLKRLFRDLFIR 279 Query: 339 ------------MLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHT 386 +L ++ S P V + PP + ++R+ Sbjct: 280 EGFQFDYVFDWTILKYQQSQIASA------PPRAVGHGAGPSGLAPPAL----QNDRQSG 329 Query: 387 IEEWKELIYKEVMNSEEKT---KNGVVKGQPSPSGAAVNSS--ESLPPSS--SVNDISSM 439 ++E + + + G + Q +P G + S + S+ + SS Sbjct: 330 VDEGRTSGWSSMDRRRAPPPIASVGTLAKQKAPVGNDASFSKEPVISASNFLGRSSGSSR 389 Query: 440 STDQTLASDT 449 + + D Sbjct: 390 RPAVSSSRDV 399 >5FQD-C nrPDB Length = 341 Score = 137 bits (346), Expect = 8e-33, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 100/256 (39%), Gaps = 26/256 (10%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 + F V +Y+ ++ IGSG+ G + A + VA+K + + E L Sbjct: 12 KAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKL----ESQKARHPQLLYESKL 67 Query: 115 MKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLY 171 K + + + + +E LVM+L+ +L + + + L Sbjct: 68 YKILQ-----GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLAD 122 Query: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK---ILDFGLARTAGTSFMM-------- 220 QM+ I+++H+ IHRD+KP N ++ ++DFGLA+ + Sbjct: 123 QMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRED 182 Query: 221 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKVIE 277 T Y + LG+ D+ S+G ++ R + + G ++ K+ E Sbjct: 183 KNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE 242 Query: 278 QLGTPCPEFMKKLQPT 293 + + E + K P Sbjct: 243 KKMSTPVEVLCKGFPA 258 >4TN6-A nrPDB Length = 318 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 100/251 (39%), Gaps = 26/251 (10%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 V RY+ + IGSG+ G + D VAIK +T + + E + K + Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL----ECVKTKHPQLHIESKIYKMMQ 60 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCG 176 + + T + E +VMEL+ +L + + + + L QM+ Sbjct: 61 -----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 177 IKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGT--------SFMMTPYVV 225 I+++HS IHRD+KP N ++ K + I+DFGLA+ Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTG 175 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKVIEQLGTP 282 T Y + LG+ D+ S+G ++ + + G ++ ++ E+ + Sbjct: 176 TARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMST 235 Query: 283 CPEFMKKLQPT 293 E + K P+ Sbjct: 236 PIEVLCKGYPS 246 >6BFN-A nrPDB Length = 342 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 48/213 (22%), Positives = 76/213 (35%), Gaps = 29/213 (13%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ--THAKRAYRELVLMKCVNHKNIISL 126 IG G G V A A+K+L + + E+ + H NI+ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 127 LNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQ------MELDHERMSYLLYQMLCGIKH 179 LV + + +L + L + +L I+ Sbjct: 87 AGYCAQNGF------YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQF 140 Query: 180 LH--SAGIIHRDLKPSNIVVKSDCTLKILDFGLA---RTAGTSFMMTPYV-------VTR 227 LH S +IH D+K SN+++ T K+ DFGLA R AG+S + V T Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHK 260 Y E I + D +S G ++ E + + Sbjct: 201 AYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >4MWI-A nrPDB Length = 294 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 47/239 (19%), Positives = 90/239 (37%), Gaps = 22/239 (9%) Query: 89 NVAIKKLSRPFQNQTH--AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVM 146 VAIK + + +E+ MK NI+ + + + +VM Sbjct: 49 PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVT--PPQFSIVM 106 Query: 147 ELMDANLCQVI---QMELDHERMSYLLYQMLCGIKHLHSAGI--IHRDLKPSNIVVKSDC 201 E + + + + +L + L+ G+ LH + +H ++ SN +V Sbjct: 107 EYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGY 166 Query: 202 TLKILDFGL-----ARTAGTSFMMTPYVVTRYYRAPEVILG--MGYKENVDIWSVGCIMG 254 +K+ F L + + GT+ T V + Y +P+ + Y +I+S G ++ Sbjct: 167 QVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLW 226 Query: 255 EMVRHKILFPGRDYIDQWNKV-----IEQLGTPCPEFMKKLQPTVRNY-VENRPKYAGL 307 E+ I F G + V E LG CP ++++ R + RP + Sbjct: 227 EIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEI 285 >4BTK-A nrPDB Length = 337 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 66/340 (19%), Positives = 126/340 (37%), Gaps = 50/340 (14%) Query: 28 VDVSYIAKHYNMS-----------KSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQG 76 VD+ ++ + ++ + ++ + + V R++ LK IG G G Sbjct: 11 VDLGTENLYFQSNAMQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFG 70 Query: 77 IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK-NIISLLNVFTPQKT 135 + A D + NVA+K Q + E+ ++K + K ++ + +K Sbjct: 71 EIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKF 126 Query: 136 LEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLK 191 Y+VM+L NL + + + L Q+L I+ +HS G +HRD+K Sbjct: 127 N------YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIK 180 Query: 192 PSNI----VVKSDCTLKILDFGLARTAGTSF-------MMTPYVVTRYYRAPEVILGMGY 240 PSN + + +LDFGLAR + + + T Y + Sbjct: 181 PSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM 240 Query: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ------LGTPCPEFMKKLQPTV 294 + D+WS+ ++ E ++ + +Q + E+ L EF L Sbjct: 241 GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIA 300 Query: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD 334 +P Y + S+F + + ++A D Sbjct: 301 SLDYFTKPDYQLIM-------SVFENSMKERGIAENEAFD 333 >5L2Q-C nrPDB Length = 320 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 112/315 (35%), Gaps = 78/315 (24%) Query: 79 CAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYR--------ELVLMKCVNHKN-IISLLN 128 C A D +K L+ + +Q + R E L+ ++ ++ ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 129 VFTPQKTL------------EEFQDVYLVME-LMDANLCQ------------VIQMELDH 163 +F + + + + LV++ L + + + L Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDFGLARTA-GTSFMMT 221 + Y ++ ++ LH I+HRDLK N+V+ + I +F L + ++ Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 222 PYVVTRYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 + Y +P+V+ G Y + D+W++G ++ M+ + F + + K+ Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKI----- 267 Query: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 K A T P+ + + L+ K+L Sbjct: 268 ----------------------KAAEYTIPE-------------DGRVSENTVCLIRKLL 292 Query: 341 VIDPAKRISVDDALQ 355 V+DP +R++ D L+ Sbjct: 293 VLDPQQRLAAADVLE 307 >4NFN-A nrPDB Length = 309 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 117/307 (38%), Gaps = 39/307 (12%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAY 109 ++ + + V R++ LK IG G G + A D + NVA+K Q + Sbjct: 9 QADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLK 64 Query: 110 RELVLMKCVNHK-NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHE 164 E+ ++K + K ++ + +K Y+VM+L NL + + + Sbjct: 65 MEVAVLKKLQGKDHVCRFIGCGRNEKFN------YVVMQLQGRNLADLRRSQPRGTFTLS 118 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNI----VVKSDCTLKILDFGLARTAGTSF-- 218 L Q+L I+ +HS G +HRD+KPSN + + +LDFGLAR + Sbjct: 119 TTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGD 178 Query: 219 -----MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWN 273 + + T Y + + D+WS+ ++ E ++ + +Q Sbjct: 179 VRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVG 238 Query: 274 KVIEQ------LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKL 327 + E+ L EF L +P Y + S+F + + Sbjct: 239 MIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIM-------SVFENSMKERGI 291 Query: 328 KASQARD 334 ++A D Sbjct: 292 AENEAFD 298 >5VC6-A nrPDB Length = 289 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 55/317 (17%), Positives = 101/317 (31%), Gaps = 71/317 (22%) Query: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHK 121 + L+ IGSG G V + AIK+ +P + A RE+ + H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 122 NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQV-IQMELDHERMSYLLYQMLCGIKHL 180 +++ + + + + L DA I + LL Q+ G++++ Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 181 HSAGIIHRDLKPSNIVVKSDCTL-------------------KILDFGLARTAGTSFMMT 221 HS ++H D+KPSNI + KI D G + + Sbjct: 132 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE 191 Query: 222 PYVVTRYYRAPEVILGMGYKE--NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL 279 + A EV+ Y DI+++ + P DQW+++ + Sbjct: 192 ---GDSRFLANEVLQ-ENYTHLPKADIFALALTVV-CAAGAEPLP--RNGDQWHEIRQGR 244 Query: 280 GTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 P+ + + + +LL M Sbjct: 245 LPRIPQVL-----------------------------------------SQEFTELLKVM 263 Query: 340 LVIDPAKRISVDDALQH 356 + DP +R S ++H Sbjct: 264 IHPDPERRPSAMALVKH 280 >5J0A-A nrPDB Length = 300 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 116/313 (37%), Gaps = 52/313 (16%) Query: 67 LKPIGSGAQGIVCAAYDAVLDR---NVAIKKLSRPFQN---QTHAKRAYRELVLMKCVNH 120 ++ +G G V + A+KK++ + + KR E ++K ++H Sbjct: 14 MQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHH 73 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMEL-MDANLCQVIQME-------LDHERMSYLLYQ 172 NI+ FT + L ME + +L +I+ + + Sbjct: 74 PNIVG-YRAFTE----ANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALN 128 Query: 173 MLCGIKHLH-SAGIIHRDLKPSNIVVKSDC-TLKILDFGLARTAGTSFMMTP----YVVT 226 M G+K+LH ++H D+K SN+V+K D T+KI D G++ + +T Y+ T Sbjct: 129 MARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGT 188 Query: 227 RYYRAPEVILGMGY-KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 ++ E + G + DI++ G + EM+ I +I+ N ++ T Sbjct: 189 EPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKTFDES 243 Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345 + RP P + E + +L S DP Sbjct: 244 DFDD--EAYYAALGTRP----------------PINMEELDESYQKVIELFSVCTNEDPK 285 Query: 346 KRISVD---DALQ 355 R S +AL+ Sbjct: 286 DRPSAAHIVEALE 298 >4RT7-A nrPDB Length = 415 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 40/158 (25%), Positives = 66/158 (41%), Gaps = 10/158 (6%) Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 L E + YQ+ G++ L +HRDL N++V +KI DFGLAR + Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 299 Query: 221 TPYVVTR---YYRAPEVILGMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVI 276 R + APE + Y D+WS G ++ E+ +PG + K+I Sbjct: 300 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 Query: 277 E---QLGTPCP--EFMKKLQPTVRNYV-ENRPKYAGLT 308 + ++ P E + + + + RP + LT Sbjct: 360 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLT 397 Score = 90.9 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 69/162 (42%), Gaps = 20/162 (12%) Query: 20 FCQGFDKQVDVSYIAKHYNMSKS-KVDNQFYSVEVGDSTFTVLKRY-----QNLKPIGSG 73 + QG + Y ++ + + DN+++ V+ + + + + + K +GSG Sbjct: 17 YFQGHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSG 76 Query: 74 AQGIVCAAYDAVLDR-----NVAIKKLSRPFQNQTHAKRAYRELVLMKCV-NHKNIISLL 127 A G V A + + VA+K L + + + + EL +M + +H+NI++LL Sbjct: 77 AFGKVMNATAYGISKTGVSIQVAVKML-KEKADSSEREALMSELKMMTQLGSHENIVNLL 135 Query: 128 NVFTPQKTLEEFQDVYLVMEL-MDANLCQVIQMELDHERMSY 168 T +YL+ E +L ++ + + ++ Sbjct: 136 GACTLSGP------IYLIFEYCCYGDLLNYLRSKREKFHRTW 171 >5X1R-A nrPDB Length = 302 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 107/277 (38%), Gaps = 46/277 (16%) Query: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK------------LSRPFQNQTHAKRA- 108 ++ + IG G GIV AYD L+R +AIK+ LS + + K Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 109 ------YRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQM--- 159 +E L+ +H ++ +L + EE Y+ + + +Q Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFW------EENGTAYMGTQFYSGTTLKNLQAQQP 134 Query: 160 -ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLAR-TAGTS 217 ++D + LL + I +H G +HRD+ NI ++ +LDFG AR G Sbjct: 135 EKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNL 194 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENV--------DIWSVGCIMGEMVRHKILFPG--RD 267 T V+ + E Y EN DI+++G ++ ++ R Sbjct: 195 SDETEIVLKPGFAPIE-----QYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVSVVRS 249 Query: 268 YIDQWNKVIEQLGTP-CPEFMKKLQPTVRNYVENRPK 303 D + + E+ PE ++ + + E+RP+ Sbjct: 250 IEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQ 286 >2PZI-A nrPDB Length = 681 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 104/268 (38%), Gaps = 25/268 (9%) Query: 10 SEPTLDVKIAFCQGFDK---QVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQN 66 + P + FC + + D + + + + V +Y+ Sbjct: 26 TNPVVPESKRFCWNCGRPVGRSDSETKGASEGWC-PYCGSPYSFLPQLNPGDIVAGQYEV 84 Query: 67 LKPIGSGAQGIVCAAYDA-VLDRNVAIKKLSRPFQNQTHA-----KRAYRELVLMKCVNH 120 I G G + A D V R V +K L + A ++ E+V H Sbjct: 85 KGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV------H 138 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDHERMSYLLYQMLCGIKH 179 +I+ + N F Y+VME + +L + +L L ++L + + Sbjct: 139 PSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 197 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFG-LARTAGTSFMMTPYVVTRYYRAPEVILGM 238 LHS G+++ DLKP NI++ + LK++D G ++R ++ T ++APE++ Sbjct: 198 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRTG 252 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGR 266 DI++VG + + GR Sbjct: 253 P-TVATDIYTVGRTLAALTLDLPTRNGR 279 >4Y12-A nrPDB Length = 375 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 56/268 (20%), Positives = 104/268 (38%), Gaps = 25/268 (9%) Query: 10 SEPTLDVKIAFCQGFDK---QVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQN 66 + P + FC + + D + + + + V +Y+ Sbjct: 65 TNPVVPESKRFCWNCGRPVGRSDSETKGASEGWC-PYCGSPYSFLPQLNPGDIVAGQYEV 123 Query: 67 LKPIGSGAQGIVCAAYDA-VLDRNVAIKKLSRPFQNQTHA-----KRAYRELVLMKCVNH 120 I G G + A D V R V +K L + A ++ E+V H Sbjct: 124 KGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVV------H 177 Query: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDHERMSYLLYQMLCGIKH 179 +I+ + N F Y+VME + +L + +L L ++L + + Sbjct: 178 PSIVQIFN-FVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 236 Query: 180 LHSAGIIHRDLKPSNIVVKSDCTLKILDFG-LARTAGTSFMMTPYVVTRYYRAPEVILGM 238 LHS G+++ DLKP NI++ + LK++D G ++R ++ T ++APE++ Sbjct: 237 LHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVRTG 291 Query: 239 GYKENVDIWSVGCIMGEMVRHKILFPGR 266 DI++VG + + GR Sbjct: 292 P-TVATDIYTVGRTLAALTLDLPTRNGR 318 >4JRN-A nrPDB Length = 372 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 65/349 (18%), Positives = 112/349 (32%), Gaps = 91/349 (26%) Query: 42 SKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK-LSRPFQ 100 V +F SV G++ V P+GSG V A D + +A+K +S Sbjct: 53 PDVPKRFVSVTTGETRTLV-----RGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEP 107 Query: 101 NQTHAKRAYRELVLMKCVN----------------HKNIISLLN-----VFTPQKTLEEF 139 RE + + +++ L T Sbjct: 108 TDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWV 167 Query: 140 QDVYLVMELMDANLCQVI----------QMELDHERMSYLLYQMLCGIKHLHSAGIIHRD 189 + +L+M +A++ +VI + E YL Q + + ++ + GI+H D Sbjct: 168 PNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTD 227 Query: 190 LKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE---VILGMGYKENVDI 246 +KP+N ++ D L + DFG R + + + T Y PE G+ Y D Sbjct: 228 IKPANFLLLKDGRLFLGDFGTYRINNS---VGRAIGTPGYEPPERPFQATGITYTFPTDA 284 Query: 247 WSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAG 306 W +G + + + P D + CP + +Q Sbjct: 285 WQLGITLYCIWCKERPTPADGIWDYLHF------ADCPSTPELVQ--------------- 323 Query: 307 LTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQ 355 DL+ +L DP KR+ AL+ Sbjct: 324 ---------------------------DLIRSLLNRDPQKRMLPLQALE 345 >5OAT-A nrPDB Length = 411 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 103/305 (33%), Gaps = 57/305 (18%) Query: 55 DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAV-----LDRNVAIKKL---SRPFQNQTHAK 106 +S L KPI G G+V +A A+K + + K Sbjct: 4 ESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILK 63 Query: 107 RAYRE-----------------LVLMKCVNH----KNIISLLNVFTPQKTLEE------- 138 YRE + L H NI+++ +VFT Sbjct: 64 AMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPE 123 Query: 139 ----FQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 194 ++L+M+ D NL + LL Q+L G+ H+ + GI HRDLK N Sbjct: 124 GEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDN 183 Query: 195 IVVK----SDCTLKILDFGLA---RTAGTSFMMTPY----VVTRYYRAPEVILGMGYKE- 242 +++ L I DFG +T G S T Y APE+I Sbjct: 184 LLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFS 243 Query: 243 -----NVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 D+W+VG I E+ F G + +N L E +Q V N Sbjct: 244 VLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANL 303 Query: 298 VENRP 302 ++ P Sbjct: 304 LKRNP 308 >5VDK-A nrPDB Length = 297 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 99/297 (33%), Gaps = 47/297 (15%) Query: 59 TVLKRYQN----LKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL 114 + RY+ ++ IG G G V + AIK+ + F ++ A E+ Sbjct: 8 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYA 67 Query: 115 MKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-------LDHERM 166 + +H +++ + + + E + Q E + ++ Sbjct: 68 HAVLGHHPHVVRYYSSWAEDDHMIIQN------EYCNGGSLQAAISENTKSGNHFEEPKL 121 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNI-----------------------VVKSDCTL 203 +L Q+ G+ ++H++ ++H D+KPSNI + ++ Sbjct: 122 KDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMY 181 Query: 204 KILDFGLARTAGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKIL 262 KI D G A + + A E++ + DI+++G + + L Sbjct: 182 KIGDLGHATSIN---KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESL 238 Query: 263 FPGRDYIDQWNK--VIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSL 317 K + F L+ ++ E RP A L + SL Sbjct: 239 PTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSL 295 >5X18-A nrPDB Length = 295 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 48/235 (20%), Positives = 94/235 (40%), Gaps = 30/235 (12%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH-KN 122 Y+ K IG G+ G++ + + VAIK +T A + E K +N N Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF----EPRKTEAPQLRDEYKTYKILNGTPN 64 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGIKH 179 I + Q+ L LV++L+ +L + + + + + QM+ I+ Sbjct: 65 I--PYAYYFGQEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIED 118 Query: 180 LHSAGIIHRDLKPSNIVVKSDCT-----LKILDFGLARTAGT--------SFMMTPYVVT 226 LH+ +I+RD+KP N ++ + ++DFG+A+ T Sbjct: 119 LHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGT 178 Query: 227 RYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKVIEQ 278 Y + LG D+ ++G + +R + + G + ++ K+ E+ Sbjct: 179 ARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEK 233 >2CHL-A nrPDB Length = 351 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 60/327 (18%), Positives = 114/327 (34%), Gaps = 53/327 (16%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87 VD+ ++ V ++ K IG G G + + + Sbjct: 11 VDLGTENLYFQSM---------------GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTN 55 Query: 88 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 147 VAIK ++ A + + E K + + I + F P +V+E Sbjct: 56 EYVAIKL----EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNA-----MVLE 106 Query: 148 LMDANLCQVIQ---MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-- 202 L+ +L + + + + Q++ ++++HS +I+RD+KP N ++ Sbjct: 107 LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKT 166 Query: 203 ---LKILDFGLARTAGTSFMM--------TPYVVTRYYRAPEVILGMGYKENVDIWSVGC 251 + I+DF LA+ T Y + LG D+ ++G Sbjct: 167 QQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH 226 Query: 252 IMGEMVRHKILFPG---RDYIDQWNKV--------IEQLGTPCPEFMKKLQPTVRNYVEN 300 + +R + + G +++ K+ IE L PE L+ R Sbjct: 227 MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFE 286 Query: 301 RPKYAGLT--FPKLFPDSLFPADSEHN 325 +P Y L F LF + D E++ Sbjct: 287 KPDYDYLRKLFTDLFDRKGYMFDYEYD 313 >4XHH-A nrPDB Length = 403 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 55/296 (18%), Positives = 117/296 (39%), Gaps = 37/296 (12%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 V ++++ + IGSG+ G + + + VAI R ++ + E + K ++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYKYLS 60 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCG 176 I + F + +V++L+ +L + + + + L QM+C Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICR 115 Query: 177 IKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGT--------SFMMTPYVV 225 ++++H IHRD+KP N ++ + T+ ++DFGL++ Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTG 175 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKVIEQ---- 278 T Y + LG+ D+ S+G ++ + + + G ++++++E+ Sbjct: 176 TARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 Query: 279 ----LGTPCPEFMKKLQPTVRN-YVENRPKYAGLTFPKLFPDSLFPADSEHNKLKA 329 L P + RN + RP Y L +LF D + ++ L Sbjct: 236 SVETLCAGLPLEFSEYMNYCRNLKFDERPDY--LYLARLFKDLSIKLEYHNDHLFD 289 >4XHL-A nrPDB Length = 394 Score = 118 bits (295), Expect = 7e-27, Method: Composition-based stats. Identities = 50/271 (18%), Positives = 105/271 (38%), Gaps = 35/271 (12%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN 119 V ++++ + IGSG+ G + + + VAI R ++ + E + + ++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYRYLS 60 Query: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI---QMELDHERMSYLLYQMLCG 176 I + F + +V++L+ +L + + + L QM C Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 177 IKHLHSAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGT--------SFMMTPYVV 225 I+++H IHRD+KP N ++ + T+ ++DFGL++ Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTG 175 Query: 226 TRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG-----------RDYIDQWNK 274 T Y + LG+ D+ S+G ++ + + + G R + N Sbjct: 176 TARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNV 235 Query: 275 VIEQLGTPCPEFMKKLQPTVRN-YVENRPKY 304 +E L + P ++ +N + +P Y Sbjct: 236 SVETLCSGLPLEFQEYMAYCKNLKFDEKPDY 266 >5CEK-A nrPDB Length = 263 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 41/249 (16%), Positives = 90/249 (36%), Gaps = 55/249 (22%) Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCG 176 +H NI ++ V + Y+ E ++ ++ L E + L Q++ Sbjct: 59 SHSNITGIVEVILGE------TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSA 112 Query: 177 IKHLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 233 + H H + I+ DLK V L++ G ++ Y +PE Sbjct: 113 VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 172 Query: 234 VILGMG-YK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 ++ G Y + D+WS+G ++ ++ + F D ++K+ ++ Q Sbjct: 173 ILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI------------RRGQ 220 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 + ++ + +AR L+ +L +P++R++ Sbjct: 221 FCIPEHI------------------------------SPKARCLIRSLLRREPSERLTAP 250 Query: 352 DALQHPYIN 360 + L HP+ Sbjct: 251 EILLHPWFE 259 >6DC0-A nrPDB Length = 292 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 41/249 (16%), Positives = 90/249 (36%), Gaps = 55/249 (22%) Query: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ--MELDHERMSYLLYQMLCG 176 +H NI ++ V + Y+ E ++ ++ L E + L Q++ Sbjct: 56 SHSNITGIVEVILGE------TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSA 109 Query: 177 IKHLHSAGIIHRDLKPSNIVVK--SDCTLKILDFGLARTA-GTSFMMTPYVVTRYYRAPE 233 + H H + I+ DLK V L++ G ++ Y +PE Sbjct: 110 VAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 169 Query: 234 VILGMG-YK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 ++ G Y + D+WS+G ++ ++ + F D ++K+ ++ Q Sbjct: 170 ILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKI------------RRGQ 217 Query: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 + ++ + +AR L+ +L +P++R++ Sbjct: 218 FCIPEHI------------------------------SPKARCLIRSLLRREPSERLTAP 247 Query: 352 DALQHPYIN 360 + L HP+ Sbjct: 248 EILLHPWFE 256 >5M07-A nrPDB Length = 276 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 38/209 (18%), Positives = 78/209 (37%), Gaps = 29/209 (13%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQ-NQTHAKRAYRELVLMKCVNHKN 122 Y ++ +G+ A G V A+K LS + +R RE + + H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 I+ + + E +++ M+ +D ++ L + ++ + + Sbjct: 92 ILEVHD------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 178 KHLHSAGIIHRDLKPSNIVVKS----DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 + H G++HRD+ P+N+V+ S D + + DFG+A Y APE Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPE 192 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKIL 262 + G D +++ + Sbjct: 193 LSAGADVDGRADQYALALTAIHLFAGAPP 221 >2C47-A nrPDB Length = 313 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 110/292 (37%), Gaps = 39/292 (13%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 ++ K IG G G + + + VAIK ++ A + + E K ++ Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLSATEG 61 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGIKHL 180 + + F P +V+EL+ +L + + + + Q++ ++++ Sbjct: 62 VPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYV 116 Query: 181 HSAGIIHRDLKPSNIVVKSDCT-----LKILDFGLARTAGTSFMM--------TPYVVTR 227 H+ +I+RD+KP N +V T + I+DFGLA+ T Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 176 Query: 228 YYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKV--------I 276 Y + LG D+ ++G + +R + + G +++ K+ I Sbjct: 177 RYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 236 Query: 277 EQLGTPCPEFMKKLQPTVRN---YVENRPKYAGLTFPKLFPDSLFPADSEHN 325 E L PE M VR + + Y F LF S F D E++ Sbjct: 237 EVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYD 288 >2CMW-A nrPDB Length = 310 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 105/293 (35%), Gaps = 42/293 (14%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + K IG G G + + + VAIK ++ A + + E K + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKL----EPIKSRAPQLHLEYRFYKQLGSA--- 55 Query: 125 SLLNVFTPQKTLEEFQDVY--LVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGIKH 179 PQ Y +V+EL+ +L + + + + Q+L +++ Sbjct: 56 ---GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEY 112 Query: 180 LHSAGIIHRDLKPSNIVVKSDCT-----LKILDFGLARTAGTSFMM--------TPYVVT 226 +HS +I+RD+KP N ++ + I+DFGLA+ T Sbjct: 113 VHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 172 Query: 227 RYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNKV-------- 275 Y + LG D+ ++G + +R + + G +++ K+ Sbjct: 173 ARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTP 232 Query: 276 IEQLGTPCPEFMKKLQPTVRN---YVENRPKYAGLTFPKLFPDSLFPADSEHN 325 IE L PE M VR + + +Y F LF + D ++ Sbjct: 233 IEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYD 285 >4NT4-A nrPDB Length = 312 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 48/259 (18%), Positives = 100/259 (38%), Gaps = 34/259 (13%) Query: 60 VLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCV- 118 V ++ K IG G G + + + +VAIK ++ A + + E K + Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKAPQLHLEYRFYKLLG 65 Query: 119 NH-----KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLL 170 +H I + ++ T +V+EL+ +L + + + + + Sbjct: 66 SHADNAPDGIPRIYHLGTCGGRYNA-----MVLELLGLSLEDLFNICARKFSLKTVLMIA 120 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVV-----KSDCTLKILDFGLARTAGT--------S 217 Q+L I+++HS +I+RD+KP N ++ K + + I+DFGLA+ Sbjct: 121 KQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPY 180 Query: 218 FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQWNK 274 T Y + +G D+ ++G + +R + + G +++ K Sbjct: 181 REHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQK 240 Query: 275 VIEQLGTPCPEFMKKLQPT 293 + + E + P Sbjct: 241 IGDTKRATPIEVLCDGHPE 259 >1CSN-A nrPDB Length = 298 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 100/272 (36%), Gaps = 38/272 (13%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 + V Y+ + IG G+ G++ + + ++ VAIK + + YR Sbjct: 1 MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTY 59 Query: 113 VLMKCVNH-KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSY 168 L+ N+ F +E LV++L+ +L ++ + + ++ Sbjct: 60 KLLAGCTGIPNV----YYF-----GQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAM 110 Query: 169 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-----LKILDFGL--------ARTAG 215 QML ++ +H +++RD+KP N ++ + + ++DFG+ + Sbjct: 111 AAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHI 170 Query: 216 TSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPG---RDYIDQW 272 T Y + LG D+ ++G + +R + + G ++ Sbjct: 171 PYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKY 230 Query: 273 NKVIEQ--------LGTPCPEFMKKLQPTVRN 296 ++ E+ L PE K RN Sbjct: 231 ERIGEKKQSTPLRELCAGFPEEFYKYMHYARN 262 >6EQI-C nrPDB Length = 433 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 105/329 (31%), Gaps = 68/329 (20%) Query: 50 SVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA-----VLDRNVAIKKL---SRPFQN 101 S V L +PI G +V +A L +A+K + + Sbjct: 3 SENVEQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNS 62 Query: 102 QTHAKRAYRE---------------LVLMKCVN-----HKNIISLLNVFTP--------- 132 K YRE + + H NI+ + +VF Sbjct: 63 TAILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNK 122 Query: 133 ------------QKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQML-CGIKH 179 + ++LVM+ D L + ++ + + R S LL L + H Sbjct: 123 QLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAH 182 Query: 180 LHSAGIIHRDLKPSNIVVKSD-----CTLKILDFGLARTAGTSFMMTPYV-------VTR 227 ++ I HRDLK NI+V T+ I DFG + ++ PY R Sbjct: 183 MNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNR 242 Query: 228 YYRAPEVILGMGYK------ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 APE+ + D+W+VG I E+ F + E+ Sbjct: 243 ALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLP 302 Query: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFP 310 P+ + + + + + +R L Sbjct: 303 ELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >4L00-A nrPDB Length = 304 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 39/292 (13%), Positives = 94/292 (32%), Gaps = 33/292 (11%) Query: 40 SKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAY------DAVLDRNVAIK 93 + ++ Y + + K + +G G + + + D IK Sbjct: 3 TSAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIK 62 Query: 94 KLSRPFQNQTH--AKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA 151 + + + + +M+ V+HK+I+ L V + +V E ++ Sbjct: 63 VILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD------VENIMVEEFVEG 116 Query: 152 NLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT----- 202 + L + Q+ + +L ++H ++ N+++ + Sbjct: 117 GPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECG 176 Query: 203 --LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG-YKENVDIWSVGCIMGEMVR- 258 +K+ D G+ T + + + APE + D WS G + E+ Sbjct: 177 PFIKLSDPGIPITVLSRQECIERI---PWIAPECVEDSKNLSVAADKWSFGTTLWEICYN 233 Query: 259 HKILFPGRDYIDQ---WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGL 307 +I + I++ + + C E + + RP + + Sbjct: 234 GEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI 285 >3REP-A nrPDB Length = 271 Score = 104 bits (260), Expect = 7e-23, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 87/248 (35%), Gaps = 26/248 (10%) Query: 76 GIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKT 135 G + ++ +K L + ++ E ++ +H N++ +L Sbjct: 24 GELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPA 81 Query: 136 LEEFQDVYLVMELMD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAG-IIHR- 188 L+ M +L V+ +D + M G+ LH+ +I R Sbjct: 82 PHPT----LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRH 137 Query: 189 DLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKE---NVD 245 L ++++ D T +I +A SF + + APE + + D Sbjct: 138 ALNSRSVMIDEDMTARIS---MA-DVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSAD 193 Query: 246 IWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTP------CPEFMKKLQPTVRNYVE 299 +WS ++ E+V ++ F ++ KV + P P K ++ + Sbjct: 194 MWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPA 253 Query: 300 NRPKYAGL 307 RPK+ + Sbjct: 254 KRPKFDMI 261 >5USZ-A nrPDB Length = 289 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 38/262 (14%), Positives = 90/262 (34%), Gaps = 35/262 (13%) Query: 70 IGSGAQGIVCAAYDAVLDR-------NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKN 122 +G G + + V +K L + +N +++ + +M ++HK+ Sbjct: 16 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASMMSKLSHKH 73 Query: 123 IISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQMELDHERMSY---LLYQMLCGIK 178 ++ V + LV E + +L ++ + + + + Q+ + Sbjct: 74 LVLNYGVCVC------GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMH 127 Query: 179 HLHSAGIIHRDLKPSNIVV--------KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYR 230 L +IH ++ NI++ + +K+ D G++ T ++ + + Sbjct: 128 FLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---PWV 184 Query: 231 APEVILG-MGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCP---E 285 PE I D WS G + E+ D + ++ P P E Sbjct: 185 PPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAE 244 Query: 286 FMKKLQPTVRNYVENRPKYAGL 307 + + ++RP + + Sbjct: 245 LANLINNCMDYEPDHRPSFRAI 266 >4L68-A nrPDB Length = 340 Score = 99.7 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 96/287 (33%), Gaps = 39/287 (13%) Query: 76 GIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKT 135 G A +A+K LS + E+ + + H N+ LL + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGERE---FRYEMNQLWELRHSNLAPLLGFCVVE-- 107 Query: 136 LEEFQDVYLVMELMDAN----LCQVIQMELDHERMSYLLYQMLCGIKHLH---SAGIIHR 188 ++ +LV + M L + ELD + G+ LH I+H+ Sbjct: 108 ----EEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQ 163 Query: 189 DLKPSNIVVKSDCTLKILDFGLARTA-----GTSFMMTPYVVTRYYRAPEVILGMGYKEN 243 ++ S I++ D +I+D GLAR S MT + Y APE M Sbjct: 164 NICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLK 223 Query: 244 VDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQL---------------GTPCPEFMK 288 D++ +G ++ E+ G + ++QL G E + Sbjct: 224 GDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEIS 283 Query: 289 KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDL 335 K N V +RPK F SL + + Q D Sbjct: 284 KFVEIALNCVSSRPKERWSMFQAY--QSLKAIAEKQGYSFSEQDDDF 328 >5UV4-A nrPDB Length = 311 Score = 99.7 bits (247), Expect = 3e-21, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 73/208 (35%), Gaps = 21/208 (10%) Query: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLL 127 + IG G A + +K L F K RE+ + V H N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK--KEFSREIKKLGSVRHPNLVPLR 87 Query: 128 NVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHE--------RMSYLLYQMLCGIKH 179 + K E ++ + DA E D + + + + + Sbjct: 88 GYYWGPKEHERI----MISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDY 143 Query: 180 LHSAGII-HRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMTPY--VVTRYYRAPE-- 233 LH+ +I H ++K SN+++ S + + D+ L R M Y PE Sbjct: 144 LHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFS 203 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKI 261 D+++ G I+ E++ KI Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLTGKI 231 >6J6I-B nrPDB Length = 351 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 41/201 (20%), Positives = 71/201 (35%), Gaps = 24/201 (11%) Query: 79 CAAYDAVL-DRNVAIKKLSRPF--QNQTHAKRAYRELVLMKCV-NHKNIISLLNVFTPQK 134 Y + DR+ IK+ S + K Y ++VL + NH N + LL Sbjct: 72 YKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL--- 128 Query: 135 TLEEFQDVYLVMELMDANLCQVI--------QMELDHERMSYLLYQMLCGIKHLHS---A 183 EF LV E + + L + ++ + +LH+ Sbjct: 129 ---EFPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPK 185 Query: 184 GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP---YVVTRYYRAPEVILGMGY 240 IIHRD+KP ++ + + T K+ D + + + T Y P Sbjct: 186 IIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFV 245 Query: 241 KENVDIWSVGCIMGEMVRHKI 261 E D++S G + ++ K Sbjct: 246 TEYTDVYSFGICLLVIITGKP 266 >5C01-A nrPDB Length = 342 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 80/244 (32%), Gaps = 28/244 (11%) Query: 81 AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQ 140 D + V +K L + A Y LM V+H ++ + V Sbjct: 101 GRDRGQELRVVLKVLDPSHHD--IALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--- 155 Query: 141 DVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 +V E ++ V + + + Q+ + +L + ++H ++ NI+ Sbjct: 156 ---MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 212 Query: 197 VKSDCT-------LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG--MGYKENVDIW 247 + +K+ D G+ A + + + APE + G +D W Sbjct: 213 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKW 269 Query: 248 SVGCIMGEM-VRHKILFPGR--DYIDQWNKVIEQLGTP-CPEFMKKLQPTVRNYVENRPK 303 G + E+ + R + + + +L P CP+ + RP Sbjct: 270 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 329 Query: 304 YAGL 307 + + Sbjct: 330 FRTI 333 >4WOV-A nrPDB Length = 317 Score = 93.2 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 80/244 (32%), Gaps = 28/244 (11%) Query: 81 AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQ 140 D + V +K L + A Y LM V+H ++ + V Sbjct: 78 GRDRGQELRVVLKVLDPSHHD--IALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--- 132 Query: 141 DVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIV 196 +V E ++ V + + + Q+ + +L + ++H ++ NI+ Sbjct: 133 ---MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 197 VKSDCT-------LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG--MGYKENVDIW 247 + +K+ D G+ A + + + APE + G +D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKW 246 Query: 248 SVGCIMGEM-VRHKILFPGR--DYIDQWNKVIEQLGTP-CPEFMKKLQPTVRNYVENRPK 303 G + E+ + R + + + +L P CP+ + RP Sbjct: 247 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPS 306 Query: 304 YAGL 307 + + Sbjct: 307 FRTI 310 >4I94-A nrPDB Length = 300 Score = 86.6 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 30/209 (14%), Positives = 77/209 (36%), Gaps = 18/209 (8%) Query: 77 IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTL 136 +V R +A+K+ +R ++ +++ E + + + + +LL Sbjct: 44 VVYKGK-LENQRRIAVKRFNR--KSWPDSRQFLEEAKAVGQLRNHRMANLLGCC------ 94 Query: 137 EEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAG-IIHRDL 190 E ++ L+ E M +L + + + +++ S G ++ DL Sbjct: 95 YEDEERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDL 154 Query: 191 KPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVG 250 ++ D ++ FGL + + + + + PE + I+S G Sbjct: 155 NAYRVLFDDDANPRLSCFGLMKNSRDGKSYSTNLA---FTPPEYLRTGRVTPESVIYSFG 211 Query: 251 CIMGEMVRHKILFPGRDYIDQWNKVIEQL 279 ++ +++ K + P ++ I+ L Sbjct: 212 TLLLDLLSGKHIPPSHALDLIRDRNIQML 240 >5CLR-A nrPDB Length = 451 Score = 86.3 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 68/189 (35%), Gaps = 24/189 (12%) Query: 79 CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEE 138 Y + +K + ++ T E + + L+ F ++T Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTE---FTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 139 FQDVYLVMELMDANLCQVIQMELDHE-------RMSYLLYQMLCGIKHLHSAGIIHRDLK 191 Y++ + + L + ++ + +K H G+IHRDLK Sbjct: 148 ----YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLK 203 Query: 192 PSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMG---YKENVDIWS 248 P NI++ +D ++DFG + + T Y APE+ + + D+++ Sbjct: 204 PGNIMLDADMQCHLVDFGSS--SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFA 261 Query: 249 VGCIMGEMV 257 + + E+ Sbjct: 262 LAYSLDELF 270 >5UU1-A nrPDB Length = 324 Score = 84.3 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 36/233 (15%), Positives = 82/233 (35%), Gaps = 36/233 (15%) Query: 61 LKRYQNLKPIGSGAQGIVCAAY-----DAVLDRNVAI------------KKLSRPFQNQT 103 ++ K IGSG G++ A+ + V + K R + Sbjct: 15 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDC 74 Query: 104 HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI--QMEL 161 K R K +++ I + + ++VME + +L ++ Sbjct: 75 IKKWIER-----KQLDYLGIPLFYGSGLTE--FKGRSYRFMVMERLGIDLQKISGQNGTF 127 Query: 162 DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSDCTLKILDFGLA-------- 211 + L +ML ++++H +H D+K +N+++ K+ + + D+GL+ Sbjct: 128 KKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGN 187 Query: 212 RTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFP 264 + T + + + G+ D+ +G M + K+ + Sbjct: 188 HKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWE 240 >2RSV-A nrPDB Length = 403 Score = 80.5 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 38/262 (14%), Positives = 94/262 (35%), Gaps = 39/262 (14%) Query: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAA-----YDAVLDR 88 A + +K + QF E+ T K ++ PIG G G + A D Sbjct: 16 AGRQSSAKRHLAEQFAVGEI--ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDA 73 Query: 89 NVAIK-------------KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKT 135 +K K + ++ R + + + + K Sbjct: 74 PCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR----TRKLKYLGVPKYWGSGLHDKN 129 Query: 136 LEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKP 192 + ++ +++M+ ++L ++ + + + L ++L ++++H +H D+K Sbjct: 130 GKSYR--FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 187 Query: 193 SNIVVK--SDCTLKILDFGLARTAGTSFMMTPYV--------VTRYYRAPEVILGMGYKE 242 SN+++ + + ++D+GLA + Y T + + + G+ Sbjct: 188 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 247 Query: 243 NVDIWSVGCIMGEMVRHKILFP 264 D+ +G M + + + + Sbjct: 248 RGDLEILGYCMIQWLTGHLPWE 269 >2LAV-A nrPDB Length = 361 Score = 80.1 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 38/262 (14%), Positives = 94/262 (35%), Gaps = 39/262 (14%) Query: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAA-----YDAVLDR 88 A + +K + QF E+ T K ++ PIG G G + A D Sbjct: 9 AGRQSSAKRHLAEQFAVGEI--ITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDA 66 Query: 89 NVAIK-------------KLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKT 135 +K K + ++ R + + + + K Sbjct: 67 PCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIR----TRKLKYLGVPKYWGSGLHDKN 122 Query: 136 LEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKP 192 + ++ +++M+ ++L ++ + + + L ++L ++++H +H D+K Sbjct: 123 GKSYR--FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 Query: 193 SNIVVK--SDCTLKILDFGLARTAGTSFMMTPYV--------VTRYYRAPEVILGMGYKE 242 SN+++ + + ++D+GLA + Y T + + + G+ Sbjct: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR 240 Query: 243 NVDIWSVGCIMGEMVRHKILFP 264 D+ +G M + + + + Sbjct: 241 RGDLEILGYCMIQWLTGHLPWE 262 >4IX6-A nrPDB Length = 350 Score = 80.1 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 58/347 (16%), Positives = 100/347 (28%), Gaps = 89/347 (25%) Query: 69 PIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR-ELVLMKCVNHKNI---- 123 P+GSG G V V L + A+ E+ + V H N Sbjct: 27 PLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTC 81 Query: 124 ISLLNVFTPQKTLEEFQDVYLVME---LMDAN--------LCQVIQMELDHERM------ 166 + + E LM AN L + L Sbjct: 82 ARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATE 141 Query: 167 ----SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV--KSDCTLKILDFG---LARTAGTS 217 + ++L + LH G++HRD+KP+N++ K LK++D G L + Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 218 FMMTPYVVT--RYY--------RAP--------------EVILGMGYKENVDIWSVGCIM 253 P Y P E + WS GC+M Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS----WSAGCVM 257 Query: 254 GEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLF 313 ++ + ++++ + +G F E +Y + F L Sbjct: 258 LQLAV--VGLRTDAGLERFLADYKAVGYDVNAFRG----------EKSGEYGTMDFAALD 305 Query: 314 PDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN 360 + DL +++ + R S + AL H + + Sbjct: 306 ANGGAGW-------------DLCQRLMEAERDARASCEAALSHAFFD 339 >6G4J-A nrPDB Length = 315 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 96/285 (33%), Gaps = 57/285 (20%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI 123 Y K +G GA GIV A D +VA+K + E+ ++K + Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFSKA-- 76 Query: 124 ISLLNVFTPQKTLEEFQDVYL----------VMELMDANLCQVIQMELDHERMSYLLYQM 173 T + + D Y+ ME + L + E + L+ Q+ Sbjct: 77 ----QSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQL 132 Query: 174 LCGIKHLHSAGIIHRDLKPSNIVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAP 232 L + LH G I DLKP N++V ++ +D G T + Y T +Y Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG--GTTKEGRAIKEY--TEFY--- 185 Query: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 GY W G E P D +I + + + + Sbjct: 186 ----DRGY------WGYGTRKAE--------PSYDLFAVAMIMINSVHKKEFKKTNQPKE 227 Query: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLS 337 +R+ +E P + + +LF A + + +D+L Sbjct: 228 QLRSLIEGNP------LLQKYKKALFSALNGDYQSADEMKKDMLD 266 >5DMZ-A nrPDB Length = 365 Score = 73.9 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 89/271 (32%), Gaps = 41/271 (15%) Query: 70 IGSGAQGIVCAAY-----DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 +G GA V A DA + +K + + E L + H + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLME-RLKPSMQHMF-M 130 Query: 125 SLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME-LDHERMSYLLYQMLCGIKHLHS 182 + Q ++Y L++A NL + + + + +ML I+ +H Sbjct: 131 KFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHD 190 Query: 183 AGIIHRDLKPSNIVVKSDCT-----------LKILDFGLA---RTAGTSFMMTPYVVTRY 228 IIH D+KP N ++ + L ++D G + + + T T Sbjct: 191 CEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSG 250 Query: 229 YRAPEVILGMGYKENVDIWSVGCIMGEMVRHKI--------------LFPGRDYIDQWNK 274 ++ E++ + +D + V + M+ LF ++D WN+ Sbjct: 251 FQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNE 310 Query: 275 VIEQLGTPCP----EFMKKLQPTVRNYVENR 301 + + L+ ++ + Sbjct: 311 FFHVMLNIPDCHHLPSLDLLRQKLKKVFQQH 341 >4CI6-B nrPDB Length = 643 Score = 72.0 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 50/295 (16%), Positives = 97/295 (32%), Gaps = 58/295 (19%) Query: 94 KLSRPFQNQTHAKRAYRELVLMKCV-----NHKNIISLLN-VFTPQKTLEEFQDVYLVME 147 +L + + EL K + H N+ ++ P L+M+ Sbjct: 70 RLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRY---YYALLMD 126 Query: 148 LMDA--------NLCQ-----VIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN 194 +D +L I E + ++ +++L HL AGI+H D+KP N Sbjct: 127 EVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGN 186 Query: 195 IVVKS-DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEV-ILGMGYKENVDIWSVGCI 252 +V ++D GL +G P T ++APE+ + +G E D++ Sbjct: 187 VVFDRASGEPVVIDLGLHSRSGEQ----PKGFTESFKAPELGVGNLGASEKSDVF----- 237 Query: 253 MGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKL 312 + L G + ++ ++ G Y +RP AG+ Sbjct: 238 ----LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYT 293 Query: 313 FPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAE 367 ++ +L + R ++A H +++ E Sbjct: 294 R---------------------FITDILGVSADSRPDSNEARLHEFLSDGTIDEE 327 >4O1O-A nrPDB Length = 717 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 62/159 (38%), Gaps = 16/159 (10%) Query: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 +G + + Y+ A+G + D+ VA+K+ S R +E+ Sbjct: 341 IGKLKIFIDEEYKIADT----AEGGIYLG--LYEDQEVAVKRFSEGST------RGQQEV 388 Query: 113 VLMKCVN-HKNIISLLNVFTPQKTLEEFQDV--YLVMELMDANLCQVIQMELDHERMSYL 169 ++ + N+++ + L + Y + E + + + E D + Sbjct: 389 SCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDES-ARNI 447 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 L + I LH +G H+DL+P NI++ S + DF Sbjct: 448 LSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >4OAU-C nrPDB Length = 699 Score = 66.6 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 30/184 (16%), Positives = 71/184 (38%), Gaps = 27/184 (14%) Query: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIK 93 + + K ++ Y +G F + ++Y+ ++G + + + VA+K Sbjct: 319 QSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADT----SEGGIYLGF--YEKQEVAVK 372 Query: 94 KLSRPFQNQTHAKRAYRELVLMKCVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN 152 + RA RE+ ++ + ++++ + +++ + L + Sbjct: 373 TFCEG------SPRAQREVSCLQSSRENSHLVTFYG------SESHRGHLFVCVTLCEQT 420 Query: 153 LCQVIQMELDH-------ERMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKSDCTLK 204 L + + E +L + ++ LH S G H+DL+P NI++ S Sbjct: 421 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAH 480 Query: 205 ILDF 208 + DF Sbjct: 481 LADF 484 Score = 28.5 bits (62), Expect = 5.9, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 28/79 (35%), Gaps = 3/79 (3%) Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 P+ +K+ + V K ++F L + + +DL+ ++ Sbjct: 494 PQEVKRDLEDLGRLVLYVVKKGSISFEDL---KAQSNEEVVQLSPDEETKDLIHRLFHPG 550 Query: 344 PAKRISVDDALQHPYINVW 362 R + D L HP+ W Sbjct: 551 EHVRDCLSDLLGHPFFWTW 569 >5GZA-A nrPDB Length = 290 Score = 61.2 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 42/210 (20%), Positives = 73/210 (34%), Gaps = 36/210 (17%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + +K IG GA V + + VA+ LS + +A L +++ + +++ Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLS----SDQYADDFLHGLSMLRALQSSHVV 81 Query: 125 SLLNVFTPQKTL-EEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHS- 182 +L+ V E+ + V+ L + + L + + +LHS Sbjct: 82 TLVGVCEEDAVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSS 141 Query: 183 -AGI--------IHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV----TRYY 229 AGI +H+ L S ++ SD L D A + T + Sbjct: 142 PAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLD-ALPEVEKGGLGVKCGHHELTGDF 198 Query: 230 RAPEVI------------LGMGYKENVDIW 247 APE + GY E DIW Sbjct: 199 VAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6M7Z-A nrPDB Length = 319 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 40/256 (15%), Positives = 82/256 (32%), Gaps = 78/256 (30%) Query: 143 YLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT 202 Y+ L + +++ H + L M+ +K LH+ G++HR ++ ++ V D T Sbjct: 123 YIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGT 182 Query: 203 LKILDFGLARTAGTSFMMTPYVVTRYYR-------APEV---------ILGMGYKENVDI 246 + + A GT TR + APE+ + + D+ Sbjct: 183 VVLGGLDTAAPIGTE--------TRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDV 234 Query: 247 WSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAG 306 +S+G + +++ LG Sbjct: 235 YSLGV-------------------AFRNLVQLLGN------------------------- 250 Query: 307 LTFPKLFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRISVDDALQHPYINVW-YD 364 +L P D + + D L KM+ +P R ++++ ++ P ++ Sbjct: 251 --------GNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFE 302 Query: 365 PAEVEAPPPQIYDKQL 380 E P Y + Sbjct: 303 DIEEGKARPFRYKQNR 318 >3ENH-A nrPDB Length = 540 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 36/156 (23%), Positives = 67/156 (42%), Gaps = 23/156 (14%) Query: 70 IGSGAQGIVCAAYDAVLDRNVAIK-KLSRPFQNQT-----HAKRAYRELVLMKCVNHKNI 123 IG GA+ + D+ LD +V IK ++ + ++++ R RE + + Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLA------L 395 Query: 124 ISLLNVFTPQKTLEEFQDVYLVMELMDANL-CQVIQMELDHERMSYLLYQMLCGIKHLHS 182 + + P + + ++M ++ L VI+ LD + Y++ + LH Sbjct: 396 VKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIEDNLD------IAYKIGEIVGKLHK 449 Query: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF 218 +IH DL SN + D L I+DFGL + + Sbjct: 450 NDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDE 483 >4AZW-A nrPDB Length = 471 Score = 58.9 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 35/83 (42%) Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGII 186 + E Q +LVME + L + + +L +L + L G Sbjct: 302 FDAPAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFW 361 Query: 187 HRDLKPSNIVVKSDCTLKILDFG 209 H D++P N++V + +++DFG Sbjct: 362 HDDVRPWNVMVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 58.5 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 35/83 (42%) Query: 127 LNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGII 186 + E Q +LVME + L + + +L +L + L G Sbjct: 302 FDAPAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFW 361 Query: 187 HRDLKPSNIVVKSDCTLKILDFG 209 H D++P N++V + +++DFG Sbjct: 362 HDDVRPWNVMVDARQHARLIDFG 384 >6EWX-A nrPDB Length = 484 Score = 58.1 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 73/242 (30%), Gaps = 82/242 (33%) Query: 155 QVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV----------------- 197 + E+ R+ +LL Q+ G++HL GIIHRDL N+++ Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSV 260 Query: 198 ------------------------KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPE 233 K L I +F A+ ++ APE Sbjct: 261 PTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPE 320 Query: 234 VILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 ++ Y D + G ++ E++ P P ++ Sbjct: 321 IVSASQY-RKFDEFQTGILIYELL----------------------HQPNPFEVRAQLRE 357 Query: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 E+ P L+ L + + L +L DP KRI + +A Sbjct: 358 RDYRREDLPPLPTLS------------------LYSPGLQQLAHLLLEADPIKRIRIGEA 399 Query: 354 LQ 355 + Sbjct: 400 KR 401 >2JII-A nrPDB Length = 352 Score = 58.1 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 27/178 (15%), Positives = 64/178 (35%), Gaps = 21/178 (11%) Query: 143 YLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK 198 +LV+ + +L + + L + + ++L ++ LH +H ++ NI V Sbjct: 134 FLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 199 --SDCTLKILDFGLARTAGTSFMMTPYV--------VTRYYRAPEVILGMGYKENVDIWS 248 + + +G A S YV + + ++ G G D+ S Sbjct: 194 PEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQS 253 Query: 249 VGCIMGEMVRHKILFPG--RDYIDQWNKVIEQLGTPCPE-----FMKKLQPTVRNYVE 299 +G M + + + + + D + + + P P + T++ Y++ Sbjct: 254 LGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLK 311 >5GZ9-A nrPDB Length = 305 Score = 57.7 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 74/209 (35%), Gaps = 33/209 (15%) Query: 65 QNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNII 124 + LK +G GA V + VA+ +L+R + L ++K + ++++ Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVALSRLTR----LEMKEDFLHGLQMLKSLQSEHVV 90 Query: 125 SLLNVFTPQKT-LEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA 183 +L+ T L E+ + + L + Q + L + + I +LH + Sbjct: 91 TLVGYCEEDGTILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHS 150 Query: 184 GIIHR------DLKPSNI---VVKSDCTLKILDFGLARTAGTSFMMTPYVVTRY----YR 230 + R DL P + ++ S+ ++ D + R + Sbjct: 151 PLGTRVMCDSNDL-PKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFV 209 Query: 231 APEVI------------LGMGYKENVDIW 247 APE + L Y E VDIW Sbjct: 210 APEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6BHC-A nrPDB Length = 438 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 54/315 (17%), Positives = 100/315 (31%), Gaps = 89/315 (28%) Query: 81 AYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFT--------- 131 A D + + A+K + + + H NI F Sbjct: 79 AKDPLNN--YAVKICKSKAKESQQYYHSLAVRQSLAV--HFNIQQDCGHFLAEVPNRLLP 134 Query: 132 -PQKTLEEFQDVYLVM---------ELMDANLCQVIQM-ELDHERMSYLLYQMLCGIKHL 180 + ++ V ++ + + +L Q + +L ++ LL Q+ G++HL Sbjct: 135 WEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHL 194 Query: 181 HSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYY-------- 229 + H DL+ N+++ T + FG A TS T +V+ + Sbjct: 195 KPYHVTHCDLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHL 252 Query: 230 -----------RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ 278 APE+I Y + D + G ++ EM+ Sbjct: 253 VDPEILRDQSRLAPEIITATQY-KKCDEFQTGILIYEML--------------------H 291 Query: 279 LGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSK 338 L P E P ++ R + F + L + L S Sbjct: 292 LPNPFDE-----NPELKEREYTRADLPRIPFRSPYSRGL---------------QQLASC 331 Query: 339 MLVIDPAKRISVDDA 353 +L +P++RI + DA Sbjct: 332 LLNPNPSERILISDA 346 >6EAS-A nrPDB Length = 308 Score = 55.8 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 40/264 (15%), Positives = 84/264 (31%), Gaps = 59/264 (22%) Query: 101 NQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELM-DANLCQVIQM 159 ++ + + +++ + V+HKN ++LL + +V E + L + + + Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRV----MVFEYAPNGTLFEHLHV 136 Query: 160 E----LDHERMSYLLYQMLCGIKHLHSAGI--IHRDLKPSNIVVKSDCTLKILDFGLART 213 LD + + ++H+H R+ + + + D K+ D Sbjct: 137 REAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWND 196 Query: 214 AGTSFMMTPYVVTRYYRAP--EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQ 271 A T + +P E I+ G ++ E++ ++ Sbjct: 197 AKGHNSTTNNELAF---SPDMEDIVRK----------YGMVLLEILTGRV---------- 233 Query: 272 WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKL--FPDSLFPADSEHNKLKA 329 P E L+ V Y E + L P + FP+ A E Sbjct: 234 ----------PSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEV----- 278 Query: 330 SQARDLLSKMLVIDPAKRISVDDA 353 + + DP KR + + Sbjct: 279 ------VRSCIDRDPKKRPQMKEV 296 >6G38-A nrPDB Length = 357 Score = 52.7 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 32/212 (15%), Positives = 61/212 (28%), Gaps = 52/212 (24%) Query: 28 VDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87 VD+ ++ V S ++ Q + IG G G V Sbjct: 11 VDLGTENLYFQSMGECSQK----GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT- 65 Query: 88 RNVAIKKLS---RPFQNQTHAKRAYR---ELVLMKCV----------------------- 118 VAIK ++ N +H K E+++ K + Sbjct: 66 -PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCV 124 Query: 119 ------------NHKNIISLLNVFTPQKTLEEFQDVYLVMEL-MDANLCQVIQMELDH-E 164 +H N + + +++V+E + ++ +L Sbjct: 125 QGSYPPLLLKAWDHYNSTK--GSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLA 182 Query: 165 RMSYLLYQMLCGIKHLH-SAGIIHRDLKPSNI 195 +L+Q+ + S HRDL N+ Sbjct: 183 TAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >5VE6-A nrPDB Length = 492 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 16/40 (40%), Positives = 25/40 (62%) Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV 197 + E R+ +LL Q+ G++HL GIIHRDL N+++ Sbjct: 202 EPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 37/126 (29%), Gaps = 41/126 (32%) Query: 230 RAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 APE++ Y D + G ++ E++ P P ++ Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELL----------------------HQPNPFEVRA 361 Query: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 E+ P L+ + + L +L DP KRI Sbjct: 362 QLRERDYRQEDLPPLPALSL------------------YSPGLQQLAHLLLEADPIKRIR 403 Query: 350 VDDALQ 355 + +A + Sbjct: 404 IGEAKR 409 >4CYJ-A nrPDB Length = 438 Score = 50.0 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 59/156 (37%), Gaps = 36/156 (23%) Query: 75 QG---IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM------KCVNHKNIIS 125 G V A ++ R+ A+++L R E ++ K + + +I++ Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL--------EGYRLTNEKAILNVMKDWKKIKNASIVT 116 Query: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME---------------LDHERMSYLL 170 + VFT + EF D L+ L + +Q + + + Sbjct: 117 IHEVFTTR----EFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYI 172 Query: 171 YQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 Q+ +K +HS + R L+PS I++ +++ Sbjct: 173 CQIANALKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >3BYV-A nrPDB Length = 377 Score = 48.1 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 50/155 (32%), Gaps = 14/155 (9%) Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS 217 L H L Q++ + LH G++H L+P +IV+ + + F Sbjct: 200 HKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRD 256 Query: 218 FMMTPYVVTRYYRAPEVILGM---GY--------KENVDIWSVGCIMGEMVRHKILFPGR 266 V+R + PE+ Y + D W++G ++ + + Sbjct: 257 GARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKD 316 Query: 267 DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 + + L+ +R E+R Sbjct: 317 AALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDR 351 >3Q60-A nrPDB Length = 371 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 53/374 (14%), Positives = 108/374 (28%), Gaps = 81/374 (21%) Query: 23 GFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAY 82 G+ ++ + A + V Q V ++ + ++P+ G + +V Sbjct: 23 GYCREEALKEPAAMVEAVTATVWPQNAETTVDSLLSQGERKLKLVEPLRVGDRSVVFLVR 82 Query: 83 DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNV------------- 129 D + A+K + +N E LL Sbjct: 83 DVERLEDFALKVFTMGAENSRSELERLHEATFAAA-------RLLGESPEEARDRRRLLL 135 Query: 130 ---------------FTPQKTLEEFQDVYLVM-------ELMDANLCQVIQMELDHERMS 167 +P + + L+M EL+ + L V D ++ Sbjct: 136 PSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILA 195 Query: 168 Y--LLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVV 225 L Q++ +L S G++H P N+ + D L + D ++ V Sbjct: 196 LHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVGTRGPASSV 253 Query: 226 TRYYRAPEVILGM--GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPC 283 Y E + + ++ W +G + + + F G Sbjct: 254 PVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF----------------GLVT 297 Query: 284 PEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVID 343 P ++ + + P L F P F + L+ + L D Sbjct: 298 P----GIKGSWKRPSLRVPGTDSLAFGSCTPLPDF-------------VKTLIGRFLNFD 340 Query: 344 PAKRISVDDALQHP 357 +R+ +A++ P Sbjct: 341 RRRRLLPLEAMETP 354 >4WWA-A nrPDB Length = 261 Score = 46.6 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 36/173 (20%), Positives = 63/173 (36%), Gaps = 33/173 (19%) Query: 66 NLKPIGSGAQGIV-------CAAYDAVLDRNVAIK-----KLSRPFQNQTHAK-RAYREL 112 ++ PI GA+ IV + IK + P +Q K R E Sbjct: 18 DIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNES 77 Query: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ------------VIQME 160 L+ + +I + PQ + + ++ +E + +L + + Sbjct: 78 RLLAKL---YLIP--GLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDC---TLKILDFGL 210 + ++ L ++ I LH H DL SNIV+ D T ++DFGL Sbjct: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >2W1Z-A nrPDB Length = 368 Score = 45.0 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 41/271 (15%), Positives = 79/271 (29%), Gaps = 47/271 (17%) Query: 73 GAQGIVCAAYDAVLDRNV--------------AIKKLS---------RPFQNQTHAKRAY 109 G+ I A D + AIK+LS R +NQ AK Sbjct: 70 GSY-ICLEATDQETGEPLEVHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYL 128 Query: 110 RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLC---------QVIQME 160 R + + V ++ V ++ + + M +NL Sbjct: 129 RFIFPIDLVKDPKKRKMIRVRLDERD-MWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKS 187 Query: 161 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 220 L H L Q++ L G++H D + NI++ + + F Sbjct: 188 LVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGF---EHLVRDGAS 244 Query: 221 TPYVVTRYYRAPE-----VILGMGY-----KENVDIWSVGCIMGEMVRHKILFPGRDYID 270 + R + PE ++ + D W++G + + + + Sbjct: 245 AVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELG 304 Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 + + L+ +R E+R Sbjct: 305 GIEWIYRRCKNIPQPVRALLEGFLRYSKEDR 335 >1TQM-A nrPDB Length = 282 Score = 43.5 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 34/159 (21%), Positives = 60/159 (37%), Gaps = 32/159 (20%) Query: 66 NLKPIGSGAQGIVCAAYDAVLDRNVAIK------------KLSRPFQNQTHAKRAYR--- 110 K +G G + V Y V +K K R + + + A R Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 111 -ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 E ++ + + P+ E V +MEL+DA +++E E + + Sbjct: 153 NEFRALQKLQ--------GLAVPKVYAWEGNAV--LMELIDAKELYRVRVENPDEVLDMI 202 Query: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 L ++ H GI+H DL N++V + + I+DF Sbjct: 203 LEEVAK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >3DZO-A nrPDB Length = 413 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/154 (16%), Positives = 48/154 (31%), Gaps = 13/154 (8%) Query: 158 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF------GLA 211 L H L Q++ + LH G++H L+P +IV+ + + F G + Sbjct: 205 HKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGAS 264 Query: 212 RTAGTSFMMTPYVVTRYYRAPEVILGMGY----KENVDIWSVGCIMGEMVRHKILFPGRD 267 + P T P G + D W++G + + + Sbjct: 265 AVSPIGRGFAPPETTAERMLP---FGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDA 321 Query: 268 YIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENR 301 + + L+ +R E+R Sbjct: 322 ALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDR 355 >4BWP-A nrPDB Length = 448 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 26/167 (15%), Positives = 50/167 (29%), Gaps = 43/167 (25%) Query: 79 CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEE 138 A L R + + + + + K + H N++ L VFT + Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTK--AFG 121 Query: 139 FQDVYLVMELMDAN---LCQVIQME-------------------------------LDHE 164 + LV + + L + L Sbjct: 122 DNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEA 181 Query: 165 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD----CTLKILD 207 + ++ Q+ G+K +H AG+ + L P+ I+V + I D Sbjct: 182 TIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >6G18-v nrPDB Length = 552 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 42/102 (41%), Gaps = 13/102 (12%) Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDHERM 166 A +E MK +L P ++ +VMEL++ LCQ+ +E Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVY 209 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 + ++ L + G+IH D N+++ + ++DF Sbjct: 210 DEAMELIVK----LANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 38.5 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 42/102 (41%), Gaps = 13/102 (12%) Query: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDHERM 166 A +E MK +L P ++ +VMEL++ LCQ+ +E Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVY 209 Query: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDF 208 + ++ L + G+IH D N+++ + ++DF Sbjct: 210 DEAMELIVK----LANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FAI-l nrPDB Length = 425 Score = 35.8 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 33/172 (19%), Positives = 60/172 (34%), Gaps = 39/172 (22%) Query: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKK-----------------LSRPFQNQT--- 103 Y IG G + + D +K L + Q Sbjct: 95 YSVGNTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 104 -HAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELD 162 A +E M + K F + + + + +VMEL++ + ++ Sbjct: 154 LSRLAANKEYQFMSMLYSKG-------FKVPEPFDNSRHI-VVMELIEGYPMRRLRK--- 202 Query: 163 HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS------DCTLKILDF 208 H+ + L ++C I L ++G+IH D NI++K DC ++DF Sbjct: 203 HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >4CZY-B nrPDB Length = 429 Score = 35.0 bits (79), Expect = 0.078, Method: Composition-based stats. Identities = 19/148 (12%), Positives = 51/148 (34%), Gaps = 31/148 (20%) Query: 79 CAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLM------KCVNHKNIISLLNVFTP 132 A + R+ A++++ R E ++ K + + NI+++ FT Sbjct: 61 YKAQNNKNGRHFALRRI--------EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTT 112 Query: 133 QKTLEEFQDVYLVMEL--MDANLCQVIQM------------ELDHERMSYLLYQMLCGIK 178 + + V + + L ++ + + Q+ + Sbjct: 113 E--FFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALL 170 Query: 179 HLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 +H+A + R L+ S I + + +++ Sbjct: 171 AIHNAKLAARCLELSKI-IWENNRIRLA 197 >5YK0-A nrPDB Length = 452 Score = 34.6 bits (78), Expect = 0.097, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 57/178 (32%), Gaps = 56/178 (31%) Query: 76 GIVCAAYDAVLDRNVAIKKLSRPFQNQT---HAKRAYRELVLMKCV-------------- 118 G V A R VA+K + P ++ K R + ++K + Sbjct: 146 GQVHKAIW-SDGREVAVK-IQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELV 203 Query: 119 ------------------------NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDAN-L 153 +H F + V ++ E ++ + Sbjct: 204 ERTEMELDYRLEAANQRAFAKAYHDHPR-------FQVPHVVASAPKV-VIQEWIEGVPM 255 Query: 154 CQVIQMELDHER--MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG 209 ++I+ +R + LL ++ G++H D P N ++ D + I+DFG Sbjct: 256 AEIIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4HG2-A nrPDB Length = 257 Score = 34.6 bits (78), Expect = 0.098, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 41/128 (32%), Gaps = 8/128 (6%) Query: 286 FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQAR----DLLSKMLV 341 F P Y RP+Y F L + D+ + QA + ++ Sbjct: 7 FKDHFTPVADAYRAFRPRYPRALFRWLGEVAPARGDALDCGCGSGQASLGLAEFFERVHA 66 Query: 342 IDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNS 401 +DP + + AL+HP + PAE PP D + + W +L Sbjct: 67 VDPGE-AQIRQALRHPRVTYAVAPAEDTGLPPASVDVAIAAQAM---HWFDLDRFWAELR 122 Query: 402 EEKTKNGV 409 V Sbjct: 123 RVARPGAV 130 >5JNE-A nrPDB Length = 367 Score = 34.3 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 39/102 (38%), Gaps = 15/102 (14%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYL-----VMELMDANLCQVIQMELDHER 165 E +L K + H II + +KTL E +++ L +M L + +M+ + Sbjct: 153 EQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSL--QDPISYTRMKYPSKS 210 Query: 166 MSYLLYQMLCGIKHLHSA--------GIIHRDLKPSNIVVKS 199 ++ Q + LHS + D+ N+ + Sbjct: 211 INCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 252 >4BVU-A nrPDB Length = 211 Score = 34.3 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 57/164 (34%), Gaps = 21/164 (12%) Query: 49 YSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRA 108 + E +S ++ K IG G+ + + S ++ Sbjct: 27 FPFENNNSHAGIVTEPILGKLIGQGSTAEIFEDVNDS----------SALYKKYDLIGNQ 76 Query: 109 YRELVLMKCVNHKNIISLLNVFTPQK---TLEEFQDVYLVMELMDANLCQVIQMELDHER 165 Y E++ M + L N F + ++ DVYL M + I + Sbjct: 77 YNEILEMAWQESE----LFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDN 132 Query: 166 MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT-LKILDF 208 + L Q++C + L IIH DL N++ + L +DF Sbjct: 133 IESLYLQLICKLNEL---SIIHYDLNTGNMLYDKESESLFPIDF 173 >2EHB-D nrPDB Length = 143 Score = 33.5 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 9/53 (16%), Positives = 21/53 (39%), Gaps = 12/53 (22%) Query: 421 VNSSESLPPSSSVNDIS------------SMSTDQTLASDTDSSLEASAGPLG 461 +N+ E + S +N + + + S+ +++EA A +G Sbjct: 7 MNAFEMITLSQGLNLSALFDRRQDFVKRQTRFVSRREPSEIIANIEAVANSMG 59 >4FDJ-A nrPDB Length = 502 Score = 33.1 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 60/212 (28%), Gaps = 43/212 (20%) Query: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVI-EQLGTPCPEFMKKL 290 PE++ GY + K R E G+P F Sbjct: 99 PELLKKAGYVSK-------------IVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYD 145 Query: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 N R + + FP +L ++ ++ +A D + + Sbjct: 146 NKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKR------------ 193 Query: 351 DDALQHPYINVW-----YDPAEVEAP-----PPQIYDKQLDEREHTIEEWKELIYKEVMN 400 A HP+ W + P P Y + E + +I + EL+ Sbjct: 194 -QARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQD---- 248 Query: 401 SEEKTKNGVVKGQPSPSGAAVNSSESLPPSSS 432 + S +GAA+ S+ S+ Sbjct: 249 --LHVADNTFVFFTSDNGAALISAPEQGGSNG 278 >6EF6-A nrPDB Length = 354 Score = 33.1 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 28/76 (36%), Gaps = 14/76 (18%) Query: 147 ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSA-----------GIIHRDLKPSNI 195 E + + + + + + LH G+IH DL+ +N+ Sbjct: 178 EHCLGDTPRWGRWQDAEGVGASETALLTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANL 237 Query: 196 VVKSDC---TLKILDF 208 +V S T+ ++DF Sbjct: 238 LVDSSTPQRTITVIDF 253 >4GYG-A nrPDB Length = 397 Score = 33.1 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 37/196 (18%), Positives = 72/196 (36%), Gaps = 35/196 (17%) Query: 30 VSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVL-----KRYQNLKP--IGSGAQGIVCAAY 82 + Y+A H + ++ V + + VG + ++ + + LK +G + V A Sbjct: 82 LDYLALHTHAARKDVYSVGSRIGVGKESDIMIVADEKGKQKVLKIHRLGRISFRTVKANR 141 Query: 83 DAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDV 142 D + +R S A +E MK + + P+ + Sbjct: 142 DYLRNR-------STGSWMYLSRLAAIKEFAFMKALYEE------GFPVPEPIAQSRHT- 187 Query: 143 YLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT 202 +VM L+DA + + D + L ++ I L G+IH D NI+++ + Sbjct: 188 -IVMSLVDALPMRQVSSVPDP---ASLYADLIALILRLAKHGLIHGDFNEFNILIREEKD 243 Query: 203 LK----------ILDF 208 + I+DF Sbjct: 244 AEDPSSITLTPIIIDF 259 >4ESA-B nrPDB Length = 146 Score = 32.3 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 23/51 (45%), Gaps = 6/51 (11%) Query: 73 GAQGIVCAAYDAVLDRNVA---IKK---LSRPFQNQTHAKRAYRELVLMKC 117 G+ G + A + ++ VA IK L R +N + K Y EL ++ Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHS 93 >3I2D-A nrPDB Length = 371 Score = 31.9 bits (71), Expect = 0.63, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 38/102 (37%), Gaps = 15/102 (14%) Query: 111 ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYL-----VMELMDANLCQVIQMELDHER 165 E +L K + H II + +KTL E +++ L +M L +M+ + Sbjct: 208 EQLLEKVLQHPKIIKQATLLYLKKTLREDEEMGLTTTSTIMSL--QCPISYTRMKYPSKS 265 Query: 166 MSYLLYQMLCGIKHLHSA--------GIIHRDLKPSNIVVKS 199 ++ Q + LHS + D+ N+ + Sbjct: 266 INCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISE 307 >6CCZ-A nrPDB Length = 455 Score = 30.8 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 32/76 (42%), Gaps = 4/76 (5%) Query: 207 DFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMG----EMVRHKIL 262 D+GL+ + R +R+ E+I + + +VG + E + K Sbjct: 6 DYGLSEADPDVHAIINKEKDRQFRSLELIASENFTSKAVMEAVGSCLTNKYSEGLPGKRY 65 Query: 263 FPGRDYIDQWNKVIEQ 278 + G ++ID+ + +Q Sbjct: 66 YGGNEHIDELEILCQQ 81 >5LJ3-H nrPDB Length = 591 Score = 30.4 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 17/30 (56%), Gaps = 1/30 (3%) Query: 187 HRDLKPSNIVVKSDCTLK-ILDFGLARTAG 215 HRDL NI++ D K ++DF L + G Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQNG 70 >4BFR-A nrPDB Length = 952 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 20/63 (31%), Gaps = 10/63 (15%) Query: 147 ELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKIL 206 E + E Y + + GI HS NI+VK L + Sbjct: 769 EYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHS----------DNIMVKKTGQLFHI 818 Query: 207 DFG 209 DFG Sbjct: 819 DFG 821 >1A9C-A nrPDB Length = 221 Score = 30.0 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 8/41 (19%), Positives = 19/41 (46%) Query: 145 VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGI 185 +M+L++ +L ME H + ++ G+ + + I Sbjct: 46 IMQLLNLDLADDSLMETPHRIAKMYVDEIFSGLDYANFPKI 86 >3JB9-c nrPDB Length = 639 Score = 29.2 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 48/140 (34%), Gaps = 13/140 (9%) Query: 271 QWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKAS 330 + K ++ P + + + G T+ K+ PD D+ Sbjct: 219 ELRKRTRKVQKEVPTGELYEKRCADEFKTRKDSGNGATYYKVIPDPSVNKDTPTESDLNR 278 Query: 331 QARDLLSKMLVIDPAKRISVDDALQHPY------INVWYDPAEVEAPPPQIYDKQLDERE 384 DLL L DP ++L+ Y P+E I K+ + + Sbjct: 279 LKADLLRAQLKKDPN-----YESLEREYQKACDDFENSLHPSENSNSQATIPSKKRNFDD 333 Query: 385 HTIEEWKELIYKEVMNSEEK 404 TI+E + ++++N + K Sbjct: 334 PTIDEMVQ--EEKLLNKQRK 351 >3J7Y-M nrPDB Length = 296 Score = 29.2 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 29/69 (42%), Gaps = 3/69 (4%) Query: 280 GTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKM 339 G P P+ M + V Y + + + L P FP++ ++ + +D L KM Sbjct: 197 GQPIPKRMLPPEELVPYYTDAKNR-GYLADPAKFPEARLELARKYGYILPDITKDELFKM 255 Query: 340 L--VIDPAK 346 L DP + Sbjct: 256 LCTRKDPRQ 264 >3URH-A nrPDB Length = 491 Score = 28.9 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 21/45 (46%), Gaps = 3/45 (6%) Query: 50 SVEVGDST--FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAI 92 V++G F + Y + IGSG G VCA A L VA+ Sbjct: 10 GVDLGTENLYFQSMMAYDLI-VIGSGPGGYVCAIKAAQLGMKVAV 53 >2Y0O-A nrPDB Length = 175 Score = 28.5 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 24/52 (46%), Gaps = 1/52 (1%) Query: 191 KPSNIVVKSD-CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYK 241 K ++ + ++++D+GL + + YV T Y + E++L G Sbjct: 14 KAGIVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVLFPGQT 65 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.136 0.405 Lambda K H 0.267 0.0417 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,352,599 Number of Sequences: 36641 Number of extensions: 757396 Number of successful extensions: 6298 Number of sequences better than 10.0: 513 Number of HSP's better than 10.0 without gapping: 938 Number of HSP's successfully gapped in prelim test: 52 Number of HSP's that attempted gapping in prelim test: 2366 Number of HSP's gapped (non-prelim): 1430 length of query: 464 length of database: 10,336,785 effective HSP length: 100 effective length of query: 364 effective length of database: 6,672,685 effective search space: 2428857340 effective search space used: 2428857340 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.1 bits)