BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P53778 (367 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1CM8-A nrPDB 762 0.0 3OHT-A nrPDB 498 e-141 4MYG-A nrPDB 495 e-140 4EWQ-A nrPDB 492 e-139 3GC9-A nrPDB 484 e-137 5AWM-A nrPDB 332 1e-91 3E7O-A nrPDB 325 1e-89 1JNK-A nrPDB 323 6e-89 2XS0-A nrPDB 323 1e-88 3FI2-A nrPDB 309 1e-84 6DTL-A nrPDB 304 4e-83 5NGU-A nrPDB 295 2e-80 4QTB-A nrPDB 292 2e-79 5Z33-A nrPDB 290 9e-79 2F9G-A nrPDB 277 6e-75 4IC8-A nrPDB 264 4e-71 4ZSG-A nrPDB 264 5e-71 4O2Z-A nrPDB 257 7e-69 4QNY-A nrPDB 251 3e-67 3PG1-A nrPDB 236 1e-62 3OZ6-A nrPDB 229 1e-60 3RP9-A nrPDB 228 2e-60 3NIE-A nrPDB 208 4e-54 3NIZ-A nrPDB 207 8e-54 2I6L-A nrPDB 204 6e-53 3N9X-A nrPDB 203 8e-53 2BPM-A nrPDB 194 8e-50 6GU6-A nrPDB 191 3e-49 1V0B-A nrPDB 181 6e-46 4KRC-A nrPDB 178 4e-45 3EB0-A nrPDB 174 5e-44 4E7W-A nrPDB 172 2e-43 4AU8-A nrPDB 172 2e-43 4NST-A nrPDB 167 5e-42 1G3N-A nrPDB 167 5e-42 5EFQ-A nrPDB 167 5e-42 5AIR-A nrPDB 164 4e-41 5G6V-A nrPDB 162 2e-40 1UA2-A nrPDB 162 3e-40 4AGU-A nrPDB 162 3e-40 4BBM-A nrPDB 162 3e-40 3MIA-A nrPDB 159 2e-39 3GC0-A nrPDB 156 1e-38 2W96-B nrPDB 155 3e-38 4BGQ-A nrPDB 152 2e-37 3ZDU-A nrPDB 150 6e-37 3E3P-A nrPDB 150 1e-36 5Y86-A nrPDB 136 1e-32 4CRL-A nrPDB 134 9e-32 5ZTN-A nrPDB 130 1e-30 5XVU-A nrPDB 129 2e-30 6HMD-A nrPDB 127 7e-30 6O6Q-A nrPDB 125 3e-29 6EII-A nrPDB 123 1e-28 4MD7-E nrPDB 121 4e-28 3NCG-A nrPDB 118 3e-27 2PVN-A nrPDB 118 3e-27 3DFA-A nrPDB 118 4e-27 3LIJ-A nrPDB 118 4e-27 6FYV-A nrPDB 117 8e-27 2F57-A nrPDB 115 2e-26 5X8I-B nrPDB 115 3e-26 2YCR-A nrPDB 114 6e-26 4FIE-A nrPDB 114 6e-26 4XBR-A nrPDB 114 8e-26 2Q0N-A nrPDB 114 9e-26 3COM-A nrPDB 113 1e-25 3I6U-A nrPDB 113 1e-25 4JDH-A nrPDB 113 1e-25 6AO5-A nrPDB 112 3e-25 4IAN-A nrPDB 112 3e-25 4RGJ-A nrPDB 112 3e-25 3MA6-A nrPDB 111 4e-25 4LFI-A nrPDB 111 4e-25 4LG4-A nrPDB 111 4e-25 5JN2-A nrPDB 111 5e-25 5UNP-A nrPDB 111 6e-25 4KS7-A nrPDB 110 7e-25 3RAW-A nrPDB 109 2e-24 3Q5I-A nrPDB 109 2e-24 3DXN-A nrPDB 108 3e-24 5XZW-A nrPDB 108 5e-24 3HZT-A nrPDB 108 5e-24 2WO6-A nrPDB 107 1e-23 4PDS-A nrPDB 106 2e-23 4NIF-A nrPDB 105 3e-23 3D2K-A nrPDB 105 4e-23 4MVF-A nrPDB 104 5e-23 4UZD-A nrPDB 104 8e-23 4FG9-A nrPDB 103 8e-23 3IS5-A nrPDB 103 1e-22 4C0T-A nrPDB 103 1e-22 2JAM-A nrPDB 102 2e-22 3ORZ-A nrPDB 102 3e-22 6FD3-A nrPDB 101 6e-22 5ES1-A nrPDB 100 7e-22 3H4J-B nrPDB 100 1e-21 6E2O-A nrPDB 100 2e-21 2HW6-A nrPDB 100 2e-21 4CZT-A nrPDB 99 2e-21 5KZ7-A nrPDB 99 2e-21 2QNJ-A nrPDB 99 2e-21 4JG6-A nrPDB 99 3e-21 2OU7-A nrPDB 99 4e-21 2Z7Q-A nrPDB 99 4e-21 4WNO-A nrPDB 99 4e-21 4J52-A nrPDB 98 5e-21 4B6L-A nrPDB 98 6e-21 2GCD-A nrPDB 97 8e-21 6C9D-A nrPDB 97 8e-21 3Q53-A nrPDB 97 8e-21 1U5R-A nrPDB 97 9e-21 3F3Z-A nrPDB 97 9e-21 2HAK-A nrPDB 97 1e-20 5YKS-A nrPDB 97 1e-20 1ZWS-A nrPDB 97 2e-20 4YZB-A nrPDB 96 2e-20 5JZN-A nrPDB 96 2e-20 2A27-A nrPDB 96 2e-20 6CMJ-A nrPDB 96 3e-20 2YAB-A nrPDB 96 3e-20 3GUB-A nrPDB 95 4e-20 3BHH-A nrPDB 95 5e-20 4EQM-A nrPDB 95 6e-20 2J90-A nrPDB 94 9e-20 5D9K-A nrPDB 94 9e-20 3MN3-A nrPDB 94 1e-19 5IG1-A nrPDB 94 1e-19 4APC-A nrPDB 93 2e-19 2JC6-A nrPDB 93 2e-19 4OW8-A nrPDB 92 3e-19 5EZV-A nrPDB 92 3e-19 4CFF-A nrPDB 92 3e-19 4KIK-B nrPDB 92 3e-19 4CQG-A nrPDB 92 3e-19 4X3F-A nrPDB 92 3e-19 4L42-A nrPDB 92 4e-19 2V7O-A nrPDB 92 4e-19 3KN6-A nrPDB 92 4e-19 5FG8-A nrPDB 92 4e-19 4CFH-A nrPDB 92 4e-19 6B2Q-A nrPDB 92 5e-19 1PHK-A nrPDB 91 6e-19 3NYO-A nrPDB 91 6e-19 4REW-A nrPDB 91 7e-19 1KOB-A nrPDB 91 7e-19 2X4F-A nrPDB 91 8e-19 4YNZ-A nrPDB 91 9e-19 4B8L-A nrPDB 91 1e-18 2VZ6-A nrPDB 91 1e-18 5YV8-A nrPDB 90 1e-18 4I6B-A nrPDB 90 1e-18 6QAU-A nrPDB 90 1e-18 4TNB-A nrPDB 90 1e-18 5U6Y-A nrPDB 90 2e-18 3UTO-A nrPDB 90 2e-18 5TQX-A nrPDB 90 2e-18 2YZA-A nrPDB 89 2e-18 1KOA-A nrPDB 89 2e-18 4RLP-A nrPDB 89 2e-18 2UV2-A nrPDB 89 3e-18 2VN9-A nrPDB 89 3e-18 2Y7J-A nrPDB 89 3e-18 6CKI-A nrPDB 89 4e-18 4U41-A nrPDB 89 4e-18 6HXF-B nrPDB 89 4e-18 3KK8-A nrPDB 89 4e-18 5D7A-A nrPDB 88 5e-18 3TAC-A nrPDB 88 6e-18 4AF3-A nrPDB 87 8e-18 2BDW-A nrPDB 87 8e-18 4RED-A nrPDB 87 9e-18 5F9E-A nrPDB 87 1e-17 3QA8-A nrPDB 87 1e-17 4D2V-A nrPDB 87 1e-17 5WAX-A nrPDB 87 1e-17 2JDO-A nrPDB 86 2e-17 3DB8-A nrPDB 86 2e-17 2JD5-A nrPDB 86 3e-17 3SOA-A nrPDB 86 3e-17 4QMW-A nrPDB 86 4e-17 1ZXE-A nrPDB 84 7e-17 4D28-A nrPDB 84 7e-17 3DLS-A nrPDB 84 8e-17 3HKO-A nrPDB 84 1e-16 5KCV-A nrPDB 83 2e-16 6CQF-A nrPDB 83 2e-16 6CCF-A nrPDB 82 3e-16 3DAK-A nrPDB 82 4e-16 2WTK-C nrPDB 82 4e-16 5O0Y-A nrPDB 82 4e-16 5J5T-A nrPDB 82 5e-16 3A4O-X nrPDB 82 5e-16 4WB7-A nrPDB 82 5e-16 2XNP-A nrPDB 82 5e-16 3MV5-A nrPDB 81 8e-16 2BRG-A nrPDB 81 8e-16 2WQN-A nrPDB 81 9e-16 6FDY-U nrPDB 80 1e-15 2H8H-A nrPDB 80 1e-15 3ZUT-A nrPDB 80 1e-15 3LM0-A nrPDB 80 1e-15 4JXF-A nrPDB 80 1e-15 3UDB-A nrPDB 80 2e-15 4UY9-A nrPDB 80 2e-15 6F3F-A nrPDB 80 2e-15 5SYS-A nrPDB 80 2e-15 6E9W-A nrPDB 80 2e-15 5X3F-B nrPDB 80 2e-15 4YHJ-A nrPDB 80 2e-15 3DTC-A nrPDB 79 2e-15 4FR4-A nrPDB 79 2e-15 1S9I-A nrPDB 79 3e-15 1FOT-A nrPDB 79 3e-15 5FET-A nrPDB 79 3e-15 5VO2-A nrPDB 79 4e-15 6ED6-A nrPDB 79 4e-15 2W1I-A nrPDB 79 5e-15 6BDL-A nrPDB 78 5e-15 5DYK-A nrPDB 78 5e-15 3UC3-A nrPDB 78 5e-15 2DQ7-X nrPDB 78 6e-15 3ALO-A nrPDB 78 6e-15 3IO7-A nrPDB 78 6e-15 2PL0-A nrPDB 77 8e-15 4UYA-A nrPDB 77 9e-15 5HI2-A nrPDB 77 1e-14 3HDN-A nrPDB 77 1e-14 6GVJ-A nrPDB 77 1e-14 5N23-A nrPDB 77 2e-14 3OMV-A nrPDB 77 2e-14 5KKR-C nrPDB 76 2e-14 4FZF-B nrPDB 76 2e-14 3EQC-A nrPDB 76 3e-14 2XIK-A nrPDB 76 3e-14 3PPZ-A nrPDB 75 3e-14 3HMP-A nrPDB 75 3e-14 4RA4-A nrPDB 75 3e-14 3UIU-A nrPDB 75 4e-14 4AN9-A nrPDB 75 5e-14 3TXO-A nrPDB 75 5e-14 6DBN-A nrPDB 75 7e-14 2W4O-A nrPDB 74 7e-14 3DKO-A nrPDB 74 7e-14 2HK5-A nrPDB 74 9e-14 5AP3-A nrPDB 74 9e-14 4E93-A nrPDB 74 9e-14 3LLT-A nrPDB 74 9e-14 5DBX-A nrPDB 74 1e-13 2ZMD-A nrPDB 74 1e-13 3VN9-A nrPDB 74 1e-13 2A1A-B nrPDB 74 1e-13 1BYG-A nrPDB 74 1e-13 5HIE-A nrPDB 74 1e-13 5TUR-A nrPDB 74 1e-13 5X5O-A nrPDB 74 1e-13 4M7I-A nrPDB 74 1e-13 5UIU-A nrPDB 73 2e-13 5UUU-A nrPDB 73 2e-13 1K9A-A nrPDB 73 2e-13 1VZO-A nrPDB 73 2e-13 1JPA-A nrPDB 73 2e-13 1AD5-A nrPDB 73 2e-13 2VWV-A nrPDB 73 2e-13 6BXI-A nrPDB 73 2e-13 3ORP-A nrPDB 73 2e-13 3PVW-A nrPDB 73 2e-13 5EG3-A nrPDB 72 3e-13 4PL5-B nrPDB 72 3e-13 4RC3-A nrPDB 72 3e-13 4WUA-A nrPDB 72 3e-13 3BGP-A nrPDB 72 4e-13 6HV0-A nrPDB 72 4e-13 5HVK-A nrPDB 72 4e-13 3FME-A nrPDB 72 5e-13 2PSQ-A nrPDB 72 6e-13 3PFQ-A nrPDB 71 6e-13 4IDT-A nrPDB 71 6e-13 2I0E-A nrPDB 71 6e-13 5L6P-A nrPDB 71 9e-13 1TKI-A nrPDB 70 1e-12 3A8W-A nrPDB 70 1e-12 2R2P-A nrPDB 70 1e-12 4XEY-B nrPDB 70 1e-12 6NPU-A nrPDB 70 2e-12 4K33-A nrPDB 70 2e-12 3C51-A nrPDB 70 2e-12 5B2L-A nrPDB 70 2e-12 3PLS-A nrPDB 70 2e-12 2Y6O-A nrPDB 69 3e-12 3GQL-A nrPDB 69 3e-12 2X7G-A nrPDB 69 4e-12 2FO0-A nrPDB 69 4e-12 4XCU-A nrPDB 69 4e-12 3TT0-A nrPDB 69 4e-12 4JLC-A nrPDB 69 4e-12 3CJF-A nrPDB 69 5e-12 5A46-A nrPDB 69 5e-12 4YFF-A nrPDB 68 5e-12 4NEU-A nrPDB 68 6e-12 5LOH-A nrPDB 68 6e-12 4AW2-A nrPDB 68 6e-12 6GQK-A nrPDB 68 6e-12 5MJB-A nrPDB 68 6e-12 5O2C-A nrPDB 68 6e-12 4P5Q-A nrPDB 68 7e-12 2RIO-A nrPDB 68 7e-12 4G3E-A nrPDB 67 8e-12 4EUT-A nrPDB 67 9e-12 6NT9-A nrPDB 67 9e-12 4HVI-A nrPDB 67 9e-12 5X02-A nrPDB 67 1e-11 4GS6-A nrPDB 67 1e-11 5O2B-A nrPDB 67 1e-11 4EUU-A nrPDB 67 1e-11 2BUJ-A nrPDB 67 1e-11 4XUF-A nrPDB 67 1e-11 4CSV-A nrPDB 67 2e-11 6O8B-A nrPDB 67 2e-11 5U6B-A nrPDB 66 2e-11 5AMN-A nrPDB 66 2e-11 4PDO-A nrPDB 66 3e-11 2XYN-A nrPDB 66 3e-11 4Y83-A nrPDB 66 3e-11 3TKU-A nrPDB 66 3e-11 4F9B-A nrPDB 65 3e-11 2H34-A nrPDB 65 6e-11 1NY3-A nrPDB 65 7e-11 2OZA-A nrPDB 64 7e-11 3KA0-A nrPDB 64 8e-11 5GRN-A nrPDB 64 1e-10 3QD2-B nrPDB 64 1e-10 4PWN-A nrPDB 64 1e-10 3KUL-B nrPDB 64 1e-10 6CTH-A nrPDB 63 2e-10 4XI2-A nrPDB 63 2e-10 2QKW-B nrPDB 63 2e-10 5WNO-A nrPDB 63 2e-10 4CRS-A nrPDB 63 2e-10 3BEA-A nrPDB 62 3e-10 5H2U-A nrPDB 62 3e-10 4TPT-A nrPDB 62 3e-10 3FXW-A nrPDB 62 4e-10 3LZB-A nrPDB 62 4e-10 5XD6-A nrPDB 62 4e-10 6E4F-A nrPDB 62 4e-10 6FER-A nrPDB 62 4e-10 5LPZ-A nrPDB 62 5e-10 3KRL-A nrPDB 62 5e-10 5LPV-A nrPDB 62 6e-10 3QGY-A nrPDB 62 6e-10 3PP0-A nrPDB 62 6e-10 3SXS-A nrPDB 62 6e-10 5FM2-A nrPDB 61 7e-10 5TOS-A nrPDB 61 1e-09 5GNK-A nrPDB 61 1e-09 4Y93-A nrPDB 60 1e-09 4X7Q-B nrPDB 60 1e-09 3QUP-A nrPDB 60 2e-09 2OGV-A nrPDB 60 2e-09 4OTD-A nrPDB 60 2e-09 5VD3-A nrPDB 59 2e-09 6FEX-A nrPDB 59 3e-09 3G0E-A nrPDB 59 4e-09 6DBM-A nrPDB 59 4e-09 6J5U-C nrPDB 59 4e-09 4E20-A nrPDB 59 4e-09 5HLW-A nrPDB 59 5e-09 1FVR-A nrPDB 59 5e-09 2J0K-A nrPDB 59 5e-09 4AT3-A nrPDB 58 5e-09 4FL3-A nrPDB 58 7e-09 3V5Q-A nrPDB 58 7e-09 4M66-A nrPDB 58 8e-09 3ZZW-A nrPDB 58 8e-09 4R7H-A nrPDB 57 9e-09 4EBW-A nrPDB 57 1e-08 3Q4U-A nrPDB 57 1e-08 4LRM-A nrPDB 57 1e-08 4OLI-A nrPDB 57 1e-08 5C26-A nrPDB 57 1e-08 3BBT-B nrPDB 57 1e-08 3MDY-A nrPDB 57 1e-08 4BTK-A nrPDB 57 2e-08 4NFN-A nrPDB 56 2e-08 4LQP-A nrPDB 56 2e-08 3C1X-A nrPDB 56 2e-08 6BSD-A nrPDB 56 2e-08 2PZI-A nrPDB 56 3e-08 4JRN-A nrPDB 56 3e-08 1U59-A nrPDB 55 4e-08 5L2Q-C nrPDB 55 4e-08 4RT7-A nrPDB 55 4e-08 4Y12-A nrPDB 55 4e-08 2WTK-B nrPDB 55 4e-08 5TE0-A nrPDB 55 4e-08 5VC6-A nrPDB 55 6e-08 2OZO-A nrPDB 55 7e-08 5IKW-A nrPDB 55 7e-08 3SOC-A nrPDB 54 8e-08 3HNG-A nrPDB 54 9e-08 5X1R-A nrPDB 54 1e-07 2VD5-A nrPDB 54 1e-07 4C59-A nrPDB 54 1e-07 2PMN-X nrPDB 54 1e-07 3UIM-A nrPDB 54 2e-07 5KMM-A nrPDB 53 2e-07 3LMG-A nrPDB 53 2e-07 5FQD-C nrPDB 53 2e-07 3ZBF-A nrPDB 52 3e-07 4H1J-A nrPDB 52 3e-07 1LUF-A nrPDB 52 4e-07 5WNL-A nrPDB 52 4e-07 5U6C-A nrPDB 52 6e-07 3M42-A nrPDB 51 6e-07 3VHK-A nrPDB 51 7e-07 5CEK-A nrPDB 51 7e-07 4HZS-A nrPDB 51 8e-07 6DC0-A nrPDB 51 8e-07 1U54-B nrPDB 51 9e-07 2Y4I-B nrPDB 51 1e-06 5E8V-A nrPDB 50 1e-06 5J0A-A nrPDB 49 3e-06 4M69-B nrPDB 49 3e-06 4CI6-B nrPDB 49 3e-06 2QLU-A nrPDB 49 4e-06 4XLV-A nrPDB 49 4e-06 3SV0-A nrPDB 48 6e-06 3I81-A nrPDB 48 6e-06 3G2F-A nrPDB 48 7e-06 4F0G-A nrPDB 48 8e-06 5AR8-A nrPDB 47 9e-06 4BTF-A nrPDB 47 1e-05 5CLR-A nrPDB 47 1e-05 1PY5-A nrPDB 46 2e-05 4XHH-A nrPDB 45 4e-05 4L68-A nrPDB 45 4e-05 3MY0-A nrPDB 45 5e-05 4XHL-A nrPDB 45 6e-05 4TN6-A nrPDB 44 8e-05 2C47-A nrPDB 43 2e-04 2CMW-A nrPDB 42 4e-04 4IX6-A nrPDB 40 0.002 2CHL-A nrPDB 40 0.002 5VDK-A nrPDB 39 0.004 5OAT-A nrPDB 39 0.005 3DAH-A nrPDB 39 0.005 5X18-A nrPDB 38 0.006 1CSN-A nrPDB 38 0.007 4NT4-A nrPDB 37 0.014 6G4J-A nrPDB 37 0.018 6BFN-A nrPDB 37 0.018 6EWX-A nrPDB 36 0.029 5VE6-A nrPDB 36 0.032 5M07-A nrPDB 35 0.057 2RSV-A nrPDB 35 0.069 2LAV-A nrPDB 34 0.099 6EQI-C nrPDB 32 0.45 5UU1-A nrPDB 32 0.49 6J6I-B nrPDB 30 1.3 4BWP-A nrPDB 30 1.4 3Q60-A nrPDB 30 1.6 3MOY-A nrPDB 30 1.7 5YK0-A nrPDB 30 2.0 6H8K-C nrPDB 29 3.1 2JJD-A nrPDB 29 3.4 6GCS-C nrPDB 29 3.5 6D3F-A nrPDB 29 3.5 4AZV-A nrPDB 29 3.8 4AZW-A nrPDB 28 5.0 2QM3-A nrPDB 28 5.3 >1CM8-A nrPDB Length = 367 Score = 762 bits (1967), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/367 (100%), Positives = 367/367 (100%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 Query: 361 VSKETPL 367 VSKETPL Sbjct: 361 VSKETPL 367 >3OHT-A nrPDB Length = 389 Score = 498 bits (1282), Expect = e-141, Method: Compositional matrix adjust. Identities = 222/347 (63%), Positives = 280/347 (80%) Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 R FYRQE+ KT WEV Y+ L PVGSGAYG+VCS+ D ++G K+A+KKL RPFQS + Sbjct: 34 RPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIH 93 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL + Sbjct: 94 AKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 153 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV Sbjct: 154 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 213 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 TRWYRAPE++LNWM Y TVDIWSVGCIMAE++TG+TLF G+DH++QL++IM++TGTPPA Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPA 273 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + R+ S EA+NY+ LP++ K++FA + A+PLAV+LLEKMLVLD ++R+TA EALA Sbjct: 274 SVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALA 333 Query: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 HPYF HD +DEP+ + YD SF+ ++EWKR+TY+EV SF+ P Sbjct: 334 HPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETP 380 >4MYG-A nrPDB Length = 372 Score = 495 bits (1275), Expect = e-140, Method: Compositional matrix adjust. Identities = 233/347 (67%), Positives = 281/347 (80%), Gaps = 2/347 (0%) Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 + GFY+Q+V KTAWE+ Y VGSGAYG+VCSA+D R+G KVAIKKL RPFQSE+F Sbjct: 26 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 AKRAYREL LLKHM+HENVIGLLDVFTP +L +F DFYLVMPFM TDL K+M E E Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 144 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 ++IQ+LVYQMLKGL+YIH+AG++HRDLKPGNLAVNEDCELKILDFGLAR AD+EMTGYVV Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 204 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 TRWYRAPEVIL+WM Y QTVDIWSVGCIMAEM+TGKTLFKG D+LDQL +I+KVTG P Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 264 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 EFVQ+L AK+Y++ LP+ +KDF + ASP A +LLEKML LD ++R+TA +AL Sbjct: 265 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 324 Query: 308 HPYFESLHDTEDEPQVQK-YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 HP+FE D E+E + Q+ +DDS + T+DEWK+ YKE+++F P Sbjct: 325 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >4EWQ-A nrPDB Length = 383 Score = 492 bits (1267), Expect = e-139, Method: Compositional matrix adjust. Identities = 222/353 (62%), Positives = 281/353 (79%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S+ R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RP Sbjct: 22 SNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP 81 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK 121 FQS + AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K Sbjct: 82 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK 141 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 +KL +D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D E Sbjct: 142 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 201 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 MTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ Sbjct: 202 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 261 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 GTP AE ++++ S+ A+NY++ L ++ K +FA++ A+PLAV+LLEKMLVLD+++R+T Sbjct: 262 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 321 Query: 302 AGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 A +ALAH YF HD +DEP YD SF+ D +DEWK +TY EV+SF PP Sbjct: 322 AAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPP 374 >3GC9-A nrPDB Length = 370 Score = 484 bits (1246), Expect = e-137, Method: Compositional matrix adjust. Identities = 221/351 (62%), Positives = 280/351 (79%), Gaps = 3/351 (0%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS P R+GFYRQE+ KT WEV + L+PVGSGAYG+VCSA D R KVA+KKL R Sbjct: 7 MSGP---RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 63 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQS + A+R YRELRLLKH++HENVIGLLDVFTP +++DF++ YLV MG DL ++ Sbjct: 64 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 123 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 K + L ++ +QFLVYQ+L+GL+YIH+AGIIHRDLKP N+AVNED EL+ILDFGLARQAD Sbjct: 124 KSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADE 183 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++ GK LF GSD++DQLK IM+ Sbjct: 184 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 243 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 V GTP E + ++ S+ A+ Y++ LP + +KD +SI A+PLA++LL +MLVLD++QRV Sbjct: 244 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 303 Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSF 351 +A EALAH YF HD EDEP+ + YD+S + +RTL+EWK +TY+EVLSF Sbjct: 304 SAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF 354 >5AWM-A nrPDB Length = 394 Score = 332 bits (852), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 173/363 (47%), Positives = 235/363 (64%), Gaps = 20/363 (5%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 A+ Y EV T + + + Y +L+P+GSGA G VC+A D T VAIKKL RPFQ+ Sbjct: 26 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 85 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126 AKRAYRE +L+K + H+N+IGLL+ FTP L++F D YLVM M +L ++++ + L Sbjct: 86 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LD 144 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTG 184 DR+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT Sbjct: 145 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 204 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 YVVTR+YRAPEVIL M YT+ VDIWSVGCIM EMI G LF G+DH+DQ +I++ GT Sbjct: 205 YVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 263 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA-------------SPLAVNLLEKM 291 P F+QRLQ +NY++ P F + + + A NLL KM Sbjct: 264 PSPSFMQRLQP-TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 322 Query: 292 LVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 LV+D EQR++ EAL H Y +D E D P + YD S D+ + T+++WK + Y+EV+ Sbjct: 323 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 382 Query: 350 SFK 352 ++ Sbjct: 383 DYE 385 >3E7O-A nrPDB Length = 360 Score = 325 bits (834), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 166/357 (46%), Positives = 233/357 (65%), Gaps = 19/357 (5%) Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A Sbjct: 6 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 65 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L + Sbjct: 66 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 124 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV Sbjct: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV 184 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G+DH+DQ ++++ GTP Sbjct: 185 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPS 243 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294 AEF+ LQ +NY++ P F + + + A +LL KMLV+ Sbjct: 244 AEFMAALQPT-VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 302 Query: 295 DAEQRVTAGEALAHPYFESLHD--TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ Sbjct: 303 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVM 359 >1JNK-A nrPDB Length = 423 Score = 323 bits (829), Expect = 6e-89, Method: Compositional matrix adjust. Identities = 168/372 (45%), Positives = 240/372 (64%), Gaps = 19/372 (5%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130 AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+ Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 166 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188 +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296 F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D Sbjct: 286 FMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344 Query: 297 EQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPP 354 +R++ +AL HPY +D + P Q YD D+ + T++EWK + YKEV++ + Sbjct: 345 AKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEK 404 Query: 355 RQLGARVSKETP 366 + G + +P Sbjct: 405 TKNGVVKGQPSP 416 >2XS0-A nrPDB Length = 386 Score = 323 bits (827), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 166/375 (44%), Positives = 240/375 (64%), Gaps = 19/375 (5%) Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 + FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ A Sbjct: 10 NNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA 69 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 KRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L ++++ E L + Sbjct: 70 KRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHE 128 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + M +V Sbjct: 129 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFV 188 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 VTR+YRAPEVIL M Y + VDIWSVGCIM EMI G LF G+DH+DQ ++++ GTP Sbjct: 189 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPC 247 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVL 294 EF+++LQ + Y++ P+ F + + + A +LL KMLV+ Sbjct: 248 PEFMKKLQPT-VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVI 306 Query: 295 DAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 DA +R++ EAL HPY +D + P + D D+ + T++EWK + YKEV+ + Sbjct: 307 DASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 366 Query: 353 PPRQLGARVSKETPL 367 + G + +PL Sbjct: 367 ERTKNGVIRGQPSPL 381 >3FI2-A nrPDB Length = 353 Score = 309 bits (791), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 161/354 (45%), Positives = 228/354 (64%), Gaps = 26/354 (7%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL RPFQ++ AKR Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69 Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130 AYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L ++++ E L +R+ Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERM 128 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVT 188 +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YVVT Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 R+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++++ GTP E Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVNLLEKMLVLDA 296 F+++LQ +NY++ P+ F + ++ + A +LL KMLV+D Sbjct: 248 FMKKLQP-TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306 Query: 297 EQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS 350 +R++ +AL HPY + D+ + T++EWK + YKEV++ Sbjct: 307 AKRISVDDALQHPYINVWYXXX---------XXXDEREHTIEEWKELIYKEVMN 351 >6DTL-A nrPDB Length = 364 Score = 304 bits (778), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 149/351 (42%), Positives = 223/351 (63%), Gaps = 7/351 (1%) Query: 11 FYRQEVTKTAWEVRAVYRD-LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 F + + +EV A Y+ + P+G GAYG VCSA++ T VAIKK+ F +++ AK Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK-HEKLGED 128 R RE++LL+HM HEN++ + D+ P + F D Y+ M TDL ++++ ++ L E+ Sbjct: 75 RTLREIKLLRHMDHENIVAIRDIIPP-PLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 133 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 Q+ +YQ+L+GL+YIH+A ++HRDLKP NL +N +C+LKI DFGLAR MT YV Sbjct: 134 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 193 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 VTRWYRAPE++LN YT +D+WSVGCI E++ K LF G DH+ QL+ +M++ GT P Sbjct: 194 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT-P 252 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 +E ++ AK Y++ LP ++ PLA++L+EKML D +R+T +AL Sbjct: 253 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 307 AHPYFESLHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 AHPY SLHD DEP+ ++ F++ + ++ K + Y+E L+F P Q Sbjct: 313 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 363 >5NGU-A nrPDB Length = 381 Score = 295 bits (756), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 146/347 (42%), Positives = 219/347 (63%), Gaps = 13/347 (3%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 V ++V Y +L +G GAYG VCSA D +VAIKK+ PF+ + + +R RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREI 91 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVY 135 ++L RHEN+IG+ D+ T++ D Y+V M TDL KL+K + L D I + +Y Sbjct: 92 KILLRFRHENIIGINDIIRA-PTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTR 189 Q+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 WYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 + + + +A+NY+ LP K + + NA A++LL+KML + +R+ +ALAHP Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 310 YFESLHDTEDEPQVQ---KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 Y E +D DEP + K+D DD+ + ++ K + ++E F+P Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQP 375 >4QTB-A nrPDB Length = 380 Score = 292 bits (747), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 147/347 (42%), Positives = 219/347 (63%), Gaps = 13/347 (3%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 V ++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R RE+ Sbjct: 32 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREI 90 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVY 135 ++L RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + +Y Sbjct: 91 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 149 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTR 189 Q+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV TR Sbjct: 150 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 209 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 WYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E Sbjct: 210 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 269 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 + + + +A+NY++ LP K +A + + A++LL++ML + +R+T EALAHP Sbjct: 270 LNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHP 329 Query: 310 YFESLHDTEDEPQVQK---YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 Y E +D DEP ++ + DD+ + + K + ++E F+P Sbjct: 330 YLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQP 374 >5Z33-A nrPDB Length = 425 Score = 290 bits (741), Expect = 9e-79, Method: Compositional matrix adjust. Identities = 145/329 (44%), Positives = 209/329 (63%), Gaps = 11/329 (3%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLD 91 +G GAYG VC+AV+ +T VAIKK+ F ++ AKRA RE++LL+H R H N+ L D Sbjct: 39 LGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYD 98 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQMLKGLRYIHAAGII 150 + P D+F + YL M DL +++ + L + Q +YQ+L GL+YIH+A ++ Sbjct: 99 MDIPRP--DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVL 156 Query: 151 HRDLKPGNLAVNEDCELKILDFGLAR--QADSE-----MTGYVVTRWYRAPEVILNWMRY 203 HRDLKPGNL VN DCELKI DFGLAR D E MT YV TRWYRAPE++L++ Y Sbjct: 157 HRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQSY 216 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK 263 T+ +D+WSVGCI+AE++ G+ FKG D++DQL +I+ + GTP E + R+ S A+ Y++ Sbjct: 217 TKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVR 276 Query: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQV 323 LP + KK F ++ NA+P A++LL++ML D R++ +AL HPY HD DEP Sbjct: 277 NLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWHDASDEPDC 336 Query: 324 QKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 + +V + E +++ EV F+ Sbjct: 337 PTTFNFDFEVVEDVGEMRKMILDEVYRFR 365 >2F9G-A nrPDB Length = 353 Score = 277 bits (708), Expect = 6e-75, Method: Compositional matrix adjust. Identities = 135/337 (40%), Positives = 204/337 (60%), Gaps = 21/337 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GAYG VCSA TG VAIKK+ PF LFA R RE+++LKH +HEN+I + ++ Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHR 152 PD + ++F + Y++ M TDL +++ + L +D IQ+ +YQ L+ ++ +H + +IHR Sbjct: 78 QRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHR 136 Query: 153 DLKPGNLAVNEDCELKILDFGLARQAD-------------SEMTGYVVTRWYRAPEVILN 199 DLKP NL +N +C+LK+ DFGLAR D S MT YV TRWYRAPEV+L Sbjct: 137 DLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLT 196 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR-LQSDEA 258 +Y++ +D+WS GCI+AE+ + +F G D+ QL I + GTP ++ R ++S A Sbjct: 197 SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRA 256 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 + Y+K LP + +P ++LL++MLV D +R+TA EAL HPY ++ HD Sbjct: 257 REYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPN 316 Query: 319 DEPQVQKYDDSFDDVDR-----TLDEWKRVTYKEVLS 350 DEP+ + SF + D T + K++ + E+ S Sbjct: 317 DEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >4IC8-A nrPDB Length = 442 Score = 264 bits (675), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 133/339 (39%), Positives = 203/339 (59%), Gaps = 9/339 (2%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LKH +H+N+ Sbjct: 57 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 116 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLRYIH 145 I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L+GL+Y+H Sbjct: 117 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMH 176 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYRAPEVIL 198 +A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWYRAPE++L Sbjct: 177 SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELML 236 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q + ++ Sbjct: 237 SLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERV 296 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 + Y++ LP + + ++ A A++LL +ML + R++A AL HP+ HD + Sbjct: 297 RAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPD 356 Query: 319 DEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 DEP +D +FD T + K E+ F R+ Sbjct: 357 DEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 395 >4ZSG-A nrPDB Length = 347 Score = 264 bits (674), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 133/339 (39%), Positives = 203/339 (59%), Gaps = 9/339 (2%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LKH +H+N+ Sbjct: 9 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI 68 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYIH 145 I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L+GL+Y+H Sbjct: 69 IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMH 128 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYRAPEVIL 198 +A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWYRAPE++L Sbjct: 129 SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELML 188 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q + ++ Sbjct: 189 SLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERV 248 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 + Y++ LP + + ++ A A++LL +ML + R++A AL HP+ HD + Sbjct: 249 RAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPD 308 Query: 319 DEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 DEP +D +FD T + K E+ F R+ Sbjct: 309 DEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 347 >4O2Z-A nrPDB Length = 377 Score = 257 bits (656), Expect = 7e-69, Method: Compositional matrix adjust. Identities = 137/357 (38%), Positives = 201/357 (56%), Gaps = 8/357 (2%) Query: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 S P F V+ + +EV + Y L+ +G GAYG CS +DG TG KV+IKK F Sbjct: 23 SVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVF 82 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTP-DETLDDFTDFYLVMPFMGTDLGKLMK 121 + KR RE+ +++ HEN++ ++++ P F D Y+V P M D+ +++ Sbjct: 83 RDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLR 142 Query: 122 HEK-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD- 179 + L E +Q+ VYQ+L+GL+Y+H+A + HRDLKP NL N CELKI+DFGL+R D Sbjct: 143 SRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDV 202 Query: 180 --SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 SE+T YV+TRWYR PE++L Y+ VDIWSVGCI AEM K +F G + +DQL+ Sbjct: 203 PYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRM 262 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 I + G PPA V+ ++ E N + K + N ++ L KM LD Sbjct: 263 IAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTE--GIDFLSKMWTLDPS 320 Query: 298 QRVTAGEALAHPYFESLHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 +R TA + LAHPY LHD EDEP + + + + E +R + +++ + P Sbjct: 321 KRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >4QNY-A nrPDB Length = 354 Score = 251 bits (642), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 124/325 (38%), Positives = 204/325 (62%), Gaps = 7/325 (2%) Query: 33 VGSGAYGAVCSAVDGRTGAK-VAIKKLYRP-FQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G+G+YG V A D ++ + VA+K++ + F+ + AKR RE++LL H +N+IGL Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQMLKGLRYIHAAGI 149 ++ TP++ ++F FY+VM M TDL ++++ ++L E IQF +YQ L+ L IH+AG+ Sbjct: 88 NILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGV 146 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILNWMRYTQT 206 IHRD+ P N+ VN +C+LKI DFGLA++ + + MT YV RWYRAPE+++ Y+ Sbjct: 147 IHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQ 206 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 +D+W +GCI+ E++ + LF+G D ++QL +I+ V GTP E + + S A+ Y+K Sbjct: 207 IDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKS 266 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKY 326 + D+ ASP A++LL MLV + ++R+T +A+ HP+ E LHD D+ Sbjct: 267 HRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHDDADDNLSYAL 326 Query: 327 DDSFDDVDRTLDEWKRVTYKEVLSF 351 ++ +T+ + KR Y+E + F Sbjct: 327 FRFDENEQKTIVDVKRAIYEESVKF 351 >3PG1-A nrPDB Length = 362 Score = 236 bits (603), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 123/319 (38%), Positives = 189/319 (59%), Gaps = 20/319 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRP---------FQSELFAKRAYRELRLLKHMRH 83 + SG+YGAVC+ VD G VAIK+++ KR RE+RLL H H Sbjct: 30 ISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHH 88 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--GEDRIQFLVYQMLKGL 141 N++GL D+F E YLV M TDL +++ +++ IQ+ +Y +L GL Sbjct: 89 PNILGLRDIFVHFEE-PAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYHILLGL 147 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILN 199 +H AG++HRDL PGN+ + ++ ++ I DF LAR+ AD+ T YV RWYRAPE+++ Sbjct: 148 HVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPELVMQ 207 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + +T+ VD+WS GC+MAEM K LF+GS +QL +I++V GTP E V S A+ Sbjct: 208 FKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSPSAR 267 Query: 260 NYMKG-LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD-- 316 +Y++ L + + + +++ A P+A++L+ KML + ++R++ +AL HPYFESL D Sbjct: 268 DYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESLFDPL 327 Query: 317 --TEDEPQVQKYDDSFDDV 333 TE + +D+S DV Sbjct: 328 DLTEGLSERFHFDESVTDV 346 >3OZ6-A nrPDB Length = 388 Score = 229 bits (585), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 123/365 (33%), Positives = 208/365 (56%), Gaps = 47/365 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HEN 85 Y ++ +G GAYG V ++D RTG VA+KK++ FQ+ A+R +RE+ +L + HEN Sbjct: 11 YELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHEN 70 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 ++ LL+V D D YLV +M TDL +++ L Q++VYQ++K ++Y+H Sbjct: 71 IVNLLNVLRADND----RDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLH 126 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLAR----------------QADSE-------- 181 + G++HRD+KP N+ +N +C +K+ DFGL+R ++E Sbjct: 127 SGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPI 186 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 +T YV TRWYRAPE++L +YT+ +D+WS+GCI+ E++ GK +F GS ++QL+ I+ V Sbjct: 187 LTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGV 246 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPE------LEKKD----FASILTNASPL------AV 285 P E V+ +QS AK ++ L E K+D + ++L +P A+ Sbjct: 247 IDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEAL 306 Query: 286 NLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDD--SFDDVDRTLDEWKRV 343 +LL+K+L + +R++A +AL HP+ H+ +EP D+V ++D+++ + Sbjct: 307 DLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSIDDYRNL 366 Query: 344 TYKEV 348 Y E+ Sbjct: 367 VYSEI 371 >3RP9-A nrPDB Length = 458 Score = 228 bits (582), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 134/404 (33%), Positives = 210/404 (51%), Gaps = 65/404 (16%) Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80 W++ Y +G+G+YG VC A D VAIKK+ R F+ + KR RE+ +L Sbjct: 49 WQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR 108 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLK 139 + H++V+ +LD+ P + ++ F + Y+V+ +D KL + L E I+ L+Y +L Sbjct: 109 LNHDHVVKVLDIVIPKD-VEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNLLV 167 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD-------------------- 179 G++Y+H+AGI+HRDLKP N VN+DC +K+ DFGLAR D Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 180 ----------SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-------- 221 ++TG+VVTRWYRAPE+IL YT+ +D+WS+GCI AE++ Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 222 ---------GKTLF-------KGSD-------HLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 G + F G+D + DQL I + GTP E ++ L+ ++A Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 K Y++ P+ E D A +S A++LL++MLV + +R+T E LAHP+F+ + E Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 319 DEPQ-VQKYDDSFDD-VDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 E +K F+D ++ + + KE+ + P QL R Sbjct: 408 VETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRR 451 >3NIE-A nrPDB Length = 429 Score = 208 bits (529), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 132/384 (34%), Positives = 190/384 (49%), Gaps = 63/384 (16%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 R Y Q +V Y +G G+YG V A D VAIKK+ R F+ + Sbjct: 10 GRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLI 69 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-L 125 KR RE+ +L ++ + +I L D+ P++ L F + Y+V+ +DL KL K L Sbjct: 70 DCKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPIFL 128 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----- 180 E ++ ++Y +L G ++IH +GIIHRDLKP N +N+DC +KI DFGLAR +S Sbjct: 129 TEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIH 188 Query: 181 -----------------------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA 217 ++T +VVTRWYRAPE+IL YT ++DIWS GCI A Sbjct: 189 IVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFA 248 Query: 218 EM-------ITGKT----LFKGS-------DH----------LDQLKEIMKVTGTPPAEF 249 E+ I T LF GS DH DQL I V GTPP E Sbjct: 249 ELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEED 308 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 ++ + E Y+K P + D + ++ S ++LLE ML +A++R+T +AL+HP Sbjct: 309 LKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHP 368 Query: 310 YF-----ESLHDTEDEPQVQKYDD 328 Y E+L + E + +DD Sbjct: 369 YLKDVRKENLENFSTEKIILPFDD 392 >3NIZ-A nrPDB Length = 311 Score = 207 bits (526), Expect = 8e-54, Method: Compositional matrix adjust. Identities = 122/305 (40%), Positives = 175/305 (57%), Gaps = 24/305 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y+ L+ VG G YG V A D + G VA+K++ + E A RE+ LLK + H N+ Sbjct: 23 YQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNI 81 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG--EDRIQFLVYQMLKGLRYI 144 + L+DV + L LV FM DL K++ K G + +I+ +YQ+L+G+ + Sbjct: 82 VSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWM 201 H I+HRDLKP NL +N D LK+ DFGLAR + Y VVT WYRAP+V++ Sbjct: 136 HQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSK 195 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP-PAEF--VQRLQSDEA 258 +Y+ +VDIWS+GCI AEMITGK LF G DQL +I + GTP P E+ VQ L + Sbjct: 196 KYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQ 255 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 + + EKK ++SI+ ++LL ML D +R++A +A+ HPYF+ L Sbjct: 256 RTFQV----FEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL---- 307 Query: 319 DEPQV 323 +PQ+ Sbjct: 308 -DPQI 311 >2I6L-A nrPDB Length = 320 Score = 204 bits (518), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 115/317 (36%), Positives = 179/317 (56%), Gaps = 18/317 (5%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 +++ + Y DL+P+G G G V SAVD +VAIKK+ K A RE+++++ Sbjct: 6 GFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIR 63 Query: 80 HMRHENVIGLLDVFTPDET--------LDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ 131 + H+N++ + ++ P + L + Y+V +M TDL +++ L E+ + Sbjct: 64 RLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHAR 123 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLARQAD------SEMTG 184 +YQ+L+GL+YIH+A ++HRDLKP NL +N ED LKI DFGLAR D ++ Sbjct: 124 LFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSE 183 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 +VT+WYR+P ++L+ YT+ +D+W+ GCI AEM+TGKTLF G+ L+Q++ I++ Sbjct: 184 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPV 243 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE 304 E Q L S Y++ K +L S AV+ LE++L R+TA E Sbjct: 244 VHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 Query: 305 ALAHPYFESLHDTEDEP 321 AL+HPY DEP Sbjct: 303 ALSHPYMSIYSFPMDEP 319 >3N9X-A nrPDB Length = 432 Score = 203 bits (517), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 133/403 (33%), Positives = 198/403 (49%), Gaps = 59/403 (14%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 R Y Q + + + L +G G+YG V A D T VAIKK+ R F+ + Sbjct: 10 GRENLYFQGIKNVHVPDNYIIKHL--IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLI 67 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-L 125 KR RE+ +L ++ + +I L D+ PD+ L F + Y+V+ +DL KL K L Sbjct: 68 DCKRILREITILNRLKSDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPIFL 126 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---- 181 E+ I+ ++Y +L G +IH +GIIHRDLKP N +N+DC +K+ DFGLAR +SE Sbjct: 127 TEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTN 186 Query: 182 ---------------------MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI 220 +T +VVTRWYRAPE+IL YT+++DIWS GCI AE++ Sbjct: 187 IVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 Query: 221 ----------TGK-TLFKGS-----------------DHLDQLKEIMKVTGTPPAEFVQR 252 T + LF GS + DQL I + GTP + ++ Sbjct: 247 NMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKN 306 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + E Y+K P + + + S +NLLE ML + +R+T +AL HPY + Sbjct: 307 INKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLK 366 Query: 313 SLHDTEDEP-QVQKYDDSFDD-VDRTLDEWKRVTYKEVLSFKP 353 + + E +K FDD + + + + + KEV SF P Sbjct: 367 DVRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFHP 409 >2BPM-A nrPDB Length = 309 Score = 194 bits (492), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 109/294 (37%), Positives = 163/294 (55%), Gaps = 14/294 (4%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 ++ ++ +G G YG V A + TG VA+KK+ ++E A RE+ LLK + H N+ Sbjct: 9 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 68 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE---DRIQFLVYQMLKGLRY 143 + LLDV + L YLV F+ DL K M L I+ ++Q+L+GL + Sbjct: 69 VKLLDVIHTENKL------YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 122 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNW 200 H+ ++HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L Sbjct: 123 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGC 182 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y+ VDIWS+GCI AEM+T + LF G +DQL I + GTP + S + Sbjct: 183 KYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS--MPD 240 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 Y P+ ++DF+ ++ +LL +ML D +R++A ALAHP+F+ + Sbjct: 241 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 294 >6GU6-A nrPDB Length = 302 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 109/297 (36%), Positives = 160/297 (53%), Gaps = 15/297 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +G G YG V TG VA+KK+ + E A RE+ LLK +RH N+ Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE----DRIQFLVYQMLKGLR 142 + L DV D L YL+ F+ DL K + G+ ++ +YQ+L+G+ Sbjct: 69 VSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILN 199 + H+ ++HRDLKP NL +++ +K+ DFGLAR + Y VVT WYR+PEV+L Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 RY+ VDIWS+G I AE+ T K LF G +DQL I + GTP E ++S + Sbjct: 183 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES--LQ 240 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 +Y P+ + AS + N ++LL KML+ D +R++ AL HPYF L + Sbjct: 241 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 297 >1V0B-A nrPDB Length = 288 Score = 181 bits (458), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 109/291 (37%), Positives = 153/291 (52%), Gaps = 14/291 (4%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y L+ +G G YG V A G A+KK+ + E RE+ +LK ++H N+ Sbjct: 4 YHGLEKIGEGTYGVVYKA-QNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNI 62 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI--QFLVYQMLKGLRYI 144 + L DV + L LV + DL KL+ + G + + + + Q+L G+ Y Sbjct: 63 VKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWM 201 H ++HRDLKP NL +N + ELKI DFGLAR + Y VVT WYRAP+V++ Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 +Y+ T+DIWSVGCI AEM+ G LF G DQL I ++ GTP ++ + E Y Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVT--ELPKY 234 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 E + S L ++LL KML LD QR+TA +AL H YF+ Sbjct: 235 DPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285 >4KRC-A nrPDB Length = 317 Score = 178 bits (451), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 164/300 (54%), Gaps = 24/300 (8%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 ++ L+ +G+G Y V ++ TG VA+K++ + E A RE+ L+K ++HEN+ Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEV-KLDSEEGTPSTAIREISLMKELKHENI 65 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE-------DRIQFLVYQMLK 139 + L DV + L LV FM DL K M +G + +++ +Q+L+ Sbjct: 66 VRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEV 196 GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 ++ Y+ ++DIWS GCI+AEMITGK LF G++ +QLK I + GTP + Sbjct: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT-- 237 Query: 257 EAKNYMKGLPELEKKDFASILT--NASPLAVNL---LEKMLVLDAEQRVTAGEALAHPYF 311 + Y + + +D +L PL NL L +L L+ + R++A +AL HP+F Sbjct: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 >3EB0-A nrPDB Length = 383 Score = 174 bits (441), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 104/326 (31%), Positives = 171/326 (52%), Gaps = 50/326 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G+G++G VC D +G + A+KK+ + + REL ++K + H N+I L+D Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHVNIIKLVDY 68 Query: 93 F--------TPDETLDDFTDF----------------------YL--VMPFMGTDLGKLM 120 F P + DD YL +M ++ L K++ Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 121 KH-----EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGL 174 K + + I +YQ+ + + +IH+ GI HRD+KP NL VN +D LK+ DFG Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGS 188 Query: 175 ARQ--ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 A++ Y+ +R+YRAPE++L YT ++D+WS+GC+ E+I GK LF G + Sbjct: 189 AKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSI 248 Query: 233 DQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP-LAVNLLEKM 291 DQL I+++ GTP E + R+ + P L+ KD+ IL +P LA++LLE++ Sbjct: 249 DQLVRIIQIMGTPTKEQMIRMNPHYTE---VRFPTLKAKDWRKILPEGTPSLAIDLLEQI 305 Query: 292 LVLDAEQRVTAGEALAHPYFESLHDT 317 L + + R+ EA+AHP+F+ L ++ Sbjct: 306 LRYEPDLRINPYEAMAHPFFDHLRNS 331 >4E7W-A nrPDB Length = 394 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 107/311 (34%), Positives = 172/311 (55%), Gaps = 21/311 (6%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 KT + Y + + +G+G++G V A + +VAIKK+ Q + F R EL++ Sbjct: 33 KTGEQREIAYTNCKVIGNGSFGVVFQAKLVESD-EVAIKKV---LQDKRFKNR---ELQI 85 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDR----IQF 132 ++ ++H NV+ L F + D LV+ ++ + + +H KL + I+ Sbjct: 86 MRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKL 145 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQ--ADSEMTGYVVTR 189 +YQ+L+ L YIH+ GI HRD+KP NL ++ LK++DFG A+ A Y+ +R Sbjct: 146 YMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSR 205 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 +YRAPE+I YT +DIWS GC+MAE++ G+ LF G +DQL EI+KV GTP E Sbjct: 206 YYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQ 265 Query: 250 VQRLQSDEAKNYMK-GLPELEKKDFASILTNASPL-AVNLLEKMLVLDAEQRVTAGEALA 307 ++ + NYM+ P++ F+ + +P A++L+ ++L R+TA EAL Sbjct: 266 IKTMNP----NYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALC 321 Query: 308 HPYFESLHDTE 318 HP+F+ L E Sbjct: 322 HPFFDELRTGE 332 >4AU8-A nrPDB Length = 296 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 105/298 (35%), Positives = 158/298 (53%), Gaps = 28/298 (9%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y L+ +G G YG V A + T VA+K++ E A RE+ LLK ++H+N+ Sbjct: 8 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 67 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRYI 144 + L DV D+ L LV F DL K + L + ++ ++Q+LKGL + Sbjct: 68 VRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWM 201 H+ ++HRDLKP NL +N + ELK+ DFGLAR + Y VVT WYR P+V+ Sbjct: 122 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 202 RYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y+ ++D+WS GCI AE+ G+ LF G+D DQLK I ++ GTP ++E Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTP---------TEEQWP 232 Query: 261 YMKGLPELE-------KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 M LP+ + +++ + +LL+ +L + QR++A EAL HPYF Sbjct: 233 SMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >4NST-A nrPDB Length = 351 Score = 167 bits (424), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 104/320 (32%), Positives = 170/320 (53%), Gaps = 19/320 (5%) Query: 17 TKTAWEVRAV--YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 T++ W R V + + +G G YG V A D TG VA+KK+ + E F A RE Sbjct: 3 TESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIRE 62 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTD----FYLVMPFMGTDLGKLMKHE--KLGED 128 +++L+ + H +V+ + ++ T + DF FYLV +M DL L++ ED Sbjct: 63 IKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSED 122 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTG 184 I+ + Q+++GL Y H +HRD+K N+ +N ++K+ DFGLAR +SE T Sbjct: 123 HIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTN 182 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 V+T WYR PE++L RYT +D+WS GCI+ E+ T K +F+ + L QL+ I ++ G+ Sbjct: 183 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGS 242 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKK---DFASILTNASPLAVNLLEKMLVLDAEQRVT 301 P + N MK + ++ +F+ I + A++LL+ ML LD +R T Sbjct: 243 PCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSA----ALDLLDHMLTLDPSKRCT 298 Query: 302 AGEALAHPYFESLHDTEDEP 321 A + L + + + ++ P Sbjct: 299 AEQTLQSDFLKDVELSKMAP 318 >1G3N-A nrPDB Length = 326 Score = 167 bits (424), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 111/300 (37%), Positives = 164/300 (54%), Gaps = 21/300 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAK-VAIKKLYRPFQSELFAKRAYRELRLLKHMR--- 82 Y + +G GAYG V A D + G + VA+K++ E RE+ +L+H+ Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE-----DRIQFLVYQM 137 H NV+ L DV T T D T LV + DL + +K+ E + I+ +++Q+ Sbjct: 73 HPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYL--DKVPEPGVPTETIKDMMFQL 129 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM--TGYVVTRWYRAPE 195 L+GL ++H+ ++HRDLKP N+ V ++K+ DFGLAR +M T VVT WYRAPE Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE-FVQRLQ 254 V+L Y VD+WSVGCI AEM K LF+GS +DQL +I+ V G P E + + + Sbjct: 190 VLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 + K +EK +T+ L +LL K L + +R++A AL+HPYF+ L Sbjct: 249 LPRQAFHSKSAQPIEK-----FVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303 >5EFQ-A nrPDB Length = 347 Score = 167 bits (424), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 101/302 (33%), Positives = 159/302 (52%), Gaps = 17/302 (5%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G YG V A D TG VA+KK+ + E F A RE+++L+ + H+++I + ++ Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 93 FTPDETLDDFTD----FYLVMPFMGTDLGKLMKHE--KLGEDRIQFLVYQMLKGLRYIHA 146 T E DF FYLV +M DL L++ E+ I+ + Q+++GL Y H Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 138 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNWMR 202 +HRD+K N+ +N ++K+ DFGLAR SE T V+T WYR PE++L R Sbjct: 139 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER 198 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 YT +D+WS GCI+ E+ T K +F+ + L QL+ I ++ G+P + N M Sbjct: 199 YTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTM 258 Query: 263 KGLPELEKK---DFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 K + +K +F I A++L + ML LD +R TA +AL + + ++ Sbjct: 259 KPKKQYRRKLREEFVFI----PAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKM 314 Query: 320 EP 321 P Sbjct: 315 PP 316 >5AIR-A nrPDB Length = 430 Score = 164 bits (416), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 97/300 (32%), Positives = 161/300 (53%), Gaps = 20/300 (6%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y D + +G+G++G V A +G VAIKK+ Q + F R EL++++ + H N+ Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV---LQDKRFKNR---ELQIMRKLDHCNI 119 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQFLVYQMLKGL 141 + L F D LV+ ++ + ++ +H + L ++ +YQ+ + L Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL 198 YIH+ GI HRD+KP NL ++ D LK+ DFG A+Q Y+ +R+YRAPE+I Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 239 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 YT ++D+WS GC++AE++ G+ +F G +DQL EI+KV GTP E ++ + Sbjct: 240 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP--- 296 Query: 259 KNYMK-GLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 NY + P+++ + + P A+ L ++L R+T EA AH +F+ L D Sbjct: 297 -NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 355 >5G6V-A nrPDB Length = 324 Score = 162 bits (410), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/295 (34%), Positives = 152/295 (51%), Gaps = 15/295 (5%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y L +G G Y V T VA+K++ R E A RE+ LLK ++H N Sbjct: 3 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI-RLEHEEGAPCTAIREVSLLKDLKHAN 61 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRY 143 ++ L D+ +++L LV ++ DL + + + ++ ++Q+L+GL Y Sbjct: 62 IVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY 115 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNW 200 H ++HRDLKP NL +NE ELK+ DFGLAR Y VVT WYR P+++L Sbjct: 116 CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGS 175 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE-FVQRLQSDEAK 259 Y+ +D+W VGCI EM TG+ LF GS +QL I ++ GTP E + L ++E K Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 235 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 Y P+ + S +LL K+L + R++A +A+ HP+F SL Sbjct: 236 TY--NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 288 >1UA2-A nrPDB Length = 346 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 105/295 (35%), Positives = 150/295 (50%), Gaps = 17/295 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL---FAKRAYRELRLLKHMRH 83 Y L +G G + V A D T VAIKK+ +SE + A RE++LL+ + H Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--GEDRIQFLVYQMLKGL 141 N+IGLLD F ++ LV FM TDL ++K L I+ + L+GL Sbjct: 72 PNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVIL 198 Y+H I+HRDLKP NL ++E+ LK+ DFGLA+ S Y VVTRWYRAPE++ Sbjct: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y VD+W+VGCI+AE++ G LDQL I + GTP E + S Sbjct: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 K P + I + A ++L++ + + + R+TA +AL YF + Sbjct: 246 YVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >4AGU-A nrPDB Length = 311 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 98/302 (32%), Positives = 161/302 (53%), Gaps = 19/302 (6%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y + +G G+YG V + TG VAIKK + K A RE+R+LK ++H N+ Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNL 64 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYI 144 + LL+VF L +LV + T L +L ++++ + E ++ + +Q L+ + + Sbjct: 65 VNLLEVFRRKRRL------HLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWM 201 H IHRD+KP N+ + + +K+ DFG AR Y V TRWYR+PE+++ Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN- 260 +Y VD+W++GC+ AE+++G L+ G +DQL I K G + + R Q + N Sbjct: 179 QYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLG----DLIPRHQQVFSTNQ 234 Query: 261 YMKGLPELEKKDFASI---LTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 Y G+ + +D + N S A+ LL+ L +D +R+T + L HPYFE++ + Sbjct: 235 YFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREI 294 Query: 318 ED 319 ED Sbjct: 295 ED 296 >4BBM-A nrPDB Length = 331 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 100/295 (33%), Positives = 159/295 (53%), Gaps = 19/295 (6%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y +L VG G+YG V + TG VAIKK ++ K A RE++LLK +RHEN+ Sbjct: 27 YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL 86 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR--IQFLVYQMLKGLRYI 144 + LL+V + +YLV F+ + ++ G D +Q ++Q++ G+ + Sbjct: 87 VNLLEVCKKKKR------WYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFC 140 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNWM 201 H+ IIHRD+KP N+ V++ +K+ DFG AR + Y V TRWYRAPE+++ + Sbjct: 141 HSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDV 200 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 +Y + VD+W++GC++ EM G+ LF G +DQL IM G + R Q KN Sbjct: 201 KYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN----LIPRHQELFNKNP 256 Query: 262 MKG---LPEL-EKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + LPE+ E++ S + ++L +K L +D ++R E L H +F+ Sbjct: 257 VFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >3MIA-A nrPDB Length = 351 Score = 159 bits (402), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 102/301 (33%), Positives = 156/301 (51%), Gaps = 16/301 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y L +G G +G V A +TG KVA+KK+ + E F A RE+++L+ ++HENV Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 87 IGLLDVFTPDETLDDFT--DFYLVMPFMGTDLGKLMKHE--KLGEDRIQFLVYQMLKGLR 142 + L+++ + + YLV F DL L+ + K I+ ++ +L GL Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-------QADSEMTGYVVTRWYRAPE 195 YIH I+HRD+K N+ + D LK+ DFGLAR + T VVT WYR PE Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF---VQR 252 ++L Y +D+W GCIMAEM T + +G+ QL I ++ G+ E V Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + E +KG K + + + P A++L++K+LVLD QR+ + +AL H +F Sbjct: 259 YELYEKLELVKGQKRKVKDRLKAYVRD--PYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 Query: 313 S 313 S Sbjct: 317 S 317 >3GC0-A nrPDB Length = 329 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 102/295 (34%), Positives = 154/295 (52%), Gaps = 18/295 (6%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR + +G G YG V A+D T VAIK++ + E A RE+ LLK ++H N+ Sbjct: 36 YRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNI 95 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLRYIH 145 I L V + L +L+ + DL K M K+ + I+ +YQ++ G+ + H Sbjct: 96 IELKSVIHHNHRL------HLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCH 149 Query: 146 AAGIIHRDLKPGNL--AVNEDCE---LKILDFGLARQAD---SEMTGYVVTRWYRAPEVI 197 + +HRDLKP NL +V++ E LKI DFGLAR + T ++T WYR PE++ Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L Y+ +VDIWS+ CI AEM+ LF G +DQL +I +V G P + + Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA-- 267 Query: 258 AKNYMKGLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 ++ + P+ K +L ++LL ML +D +R++A AL HPYF Sbjct: 268 LPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF 322 >2W96-B nrPDB Length = 306 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 108/304 (35%), Positives = 147/304 (48%), Gaps = 17/304 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR---H 83 Y + +G GAYG V A D +G VA+K + P E RE+ LL+ + H Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQMLKG 140 NV+ L+DV T D LV + DL + L + I+ L+ Q L+G Sbjct: 66 PNVVRLMDVCATSRT-DREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 124 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT--GYVVTRWYRAPEVIL 198 L ++HA I+HRDLKP N+ V +K+ DFGLAR +M VVT WYRAPEV+L Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLL 184 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y VD+WSVGCI AEM K LF G+ DQL +I + G PP + R + Sbjct: 185 Q-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR----DV 239 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 P + S++ LL +ML + +R++A AL H Y LH E Sbjct: 240 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY---LHKDE 296 Query: 319 DEPQ 322 P+ Sbjct: 297 GNPE 300 >4BGQ-A nrPDB Length = 304 Score = 152 bits (384), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 93/291 (31%), Positives = 159/291 (54%), Gaps = 20/291 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 VG GAYG V T VAIKK ++E + REL++L+ ++ EN++ L + Sbjct: 20 VGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEA 79 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG--EDRIQFLVYQMLKGLRYIHAAGII 150 F L YLV ++ ++ +L++ G ++++ +YQ++K + + H I+ Sbjct: 80 FRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV 133 Query: 151 HRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGY---VVTRWYRAPEVILNWMRYTQT 206 HRD+KP NL ++ + LK+ DFG AR ++ Y V TRWYR+PE++L Y ++ Sbjct: 134 HRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG-APYGKS 192 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK--- 263 VD+WSVGCI+ E+ G+ LF G +DQL I KV G P+E ++ S+ + ++ Sbjct: 193 VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA 252 Query: 264 -GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 P+ ++ + IL + + ++L++ +L LD R + L HP F++ Sbjct: 253 VNHPQSLERRYLGILNS---VLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 300 >3ZDU-A nrPDB Length = 325 Score = 150 bits (380), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 99/294 (33%), Positives = 153/294 (52%), Gaps = 18/294 (6%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-RPFQSELFAKRAYRELRLLKHMRHE 84 +Y L VG G+YG V TG VAIK Y RP QS K A RE++ LK HE Sbjct: 4 MYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQS--VNKIAMREIKFLKQFHHE 61 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLR 142 N++ L++VF + + +LV F+ + ++H L R++ ++Q+L+ + Sbjct: 62 NLVNLIEVFRQKKKI------HLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 115 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILN 199 Y+H+ IIHRD+KP N+ V++ K+ DFG AR + Y V TRWYRAPE++L Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI-MKVTGTPPAEFVQRLQSDEA 258 Y + VDIW++GC++ EM TG S LD L +I +KV P +Q + S Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSP--HLQNIFSKSP 233 Query: 259 KNYMKGLPELEK-KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 LP+++ K+ + L +++ L +D R+++ + L H YF Sbjct: 234 IFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 >3E3P-A nrPDB Length = 360 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 104/304 (34%), Positives = 162/304 (53%), Gaps = 33/304 (10%) Query: 34 GSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVF 93 G G +G V + TG VAIKK+ Q F R + ++ L + H N++ L F Sbjct: 32 GQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHPNIVQLQSYF 88 Query: 94 TPDETLD--DFTDFYL--VMPFMGTDLGKLMKHEKLGEDR-----IQFLVYQMLKGLRYI 144 TL D D YL VM ++ L + ++ + I+ ++Q+++ + + Sbjct: 89 Y---TLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIRSIGCL 145 Query: 145 H--AAGIIHRDLKPGNLAVNE-DCELKILDFGLARQ-ADSE-MTGYVVTRWYRAPEVILN 199 H + + HRD+KP N+ VNE D LK+ DFG A++ + SE Y+ +R+YRAPE+I Sbjct: 146 HLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFG 205 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL---QSD 256 YT VDIWSVGCI AEM+ G+ +F+G + QL EI++V G P E +++L +D Sbjct: 206 NQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTD 265 Query: 257 EAKNYMKGLPELEKKDFASILTNAS----PLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 KG+P ++++ ++ S A +LL +L E+R+ EAL HPYF+ Sbjct: 266 VDLYNSKGIP------WSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFD 319 Query: 313 SLHD 316 LHD Sbjct: 320 ELHD 323 >5Y86-A nrPDB Length = 588 Score = 136 bits (343), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 93/321 (28%), Positives = 156/321 (48%), Gaps = 41/321 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y L+ +G G++G V D + VA+K + + F ++A E+R+L+H++ ++ Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDK 265 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL---VYQMLKGLRY 143 G ++V E+ + + DL +L+K K +Q + +L+ L Sbjct: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDA 325 Query: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201 +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 326 LHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG-S 384 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 RY+ +DIWS GCI+AE++TG+ LF G D DQL +M++ G PP + ++ QS AK + Sbjct: 385 RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE--QSKRAKYF 442 Query: 262 M--KGLPEL---------------------------EKKDFASILTNASP-LAVNLLEKM 291 + KG+P KD+ + L L + L++ Sbjct: 443 INSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRC 502 Query: 292 LVLDAEQRVTAGEALAHPYFE 312 L D R+T +AL HP+ Sbjct: 503 LHWDPSARLTPAQALRHPWIS 523 >4CRL-A nrPDB Length = 406 Score = 134 bits (336), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 105/326 (32%), Positives = 160/326 (49%), Gaps = 64/326 (19%) Query: 33 VGSGAYGAV--CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 VG G YG V DG+ A+K++ + + A RE+ LL+ ++H NVI L Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQ 85 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK----------LGEDRIQFLVYQMLKG 140 VF +L+ + DL ++K + L ++ L+YQ+L G Sbjct: 86 KVFLSHAD----RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDG 141 Query: 141 LRYIHAAGIIHRDLKPGNLAV----NEDCELKILDFGLARQADS------EMTGYVVTRW 190 + Y+HA ++HRDLKP N+ V E +KI D G AR +S ++ VVT W Sbjct: 142 IHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFW 201 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF-------KGSD--HLDQLKEIMKV 241 YRAPE++L YT+ +DIW++GCI AE++T + +F K S+ H DQL I V Sbjct: 202 YRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNV 261 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEK--KDF-ASILTNASPL-------------AV 285 G P +D+ +K +PE KDF + TN S + A Sbjct: 262 MGFP---------ADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAF 312 Query: 286 NLLEKMLVLDAEQRVTAGEALAHPYF 311 +LL+K+L +D +R+T+ +A+ PYF Sbjct: 313 HLLQKLLTMDPIKRITSEQAMQDPYF 338 >5ZTN-A nrPDB Length = 429 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 94/323 (29%), Positives = 162/323 (50%), Gaps = 47/323 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y L+ +G G++G V A D + VA+K + + F ++A E+R+L+H+R ++ Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQDK 155 Query: 87 IGLLDVFTPDETLDDFT-DFYLVMPF--MGTDLGKLMKHEKL---GEDRIQFLVYQMLKG 140 ++V L++FT ++ M F + +L +L+K K ++ + +L+ Sbjct: 156 DNTMNVI---HMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCE--LKILDFGLARQADSEMTGYVVTRWYRAPEVIL 198 L +H IIH DLKP N+ + + +K++DFG + + Y+ +R+YRAPEVIL Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVIL 272 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 RY +D+WS+GCI+AE++TG L G D DQL ++++ G P + + S A Sbjct: 273 G-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLD--ASKRA 329 Query: 259 KNYM--KGLPEL---------------------------EKKDFASILTNA-SPLAVNLL 288 KN++ KG P E +++ + L PL ++ L Sbjct: 330 KNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFL 389 Query: 289 EKMLVLDAEQRVTAGEALAHPYF 311 ++ L D R+T G+AL HP+ Sbjct: 390 KQCLEWDPAVRMTPGQALRHPWL 412 >5XVU-A nrPDB Length = 332 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 69/201 (34%), Positives = 119/201 (59%), Gaps = 10/201 (4%) Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QADS 180 K + I++ +YQ+LK L Y H+ GI+HRD+KP N+ ++ E+ +++++ +GLA Sbjct: 121 KFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQ 180 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIM 239 E V +R+Y+ PE++++ Y ++DIWS+GC++A MI K F G D+ DQL +I Sbjct: 181 EYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIA 240 Query: 240 KVTGTPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLV 293 KV GT ++++ +Y+ L E E+K ++ LT A ++L++KML+ Sbjct: 241 KVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLI 300 Query: 294 LDAEQRVTAGEALAHPYFESL 314 D +R+ EA+ HPYF + Sbjct: 301 YDHAKRIAPKEAMEHPYFREV 321 >6HMD-A nrPDB Length = 365 Score = 127 bits (319), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 72/219 (32%), Positives = 131/219 (59%), Gaps = 12/219 (5%) Query: 113 GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILD 171 TD +L ++ L + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ + +L+++D Sbjct: 134 NTDFKQL--YQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLID 191 Query: 172 FGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKG 228 +GLA E V +R+++ PE+++++ Y ++D+WS+GC++A MI + F G Sbjct: 192 WGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHG 251 Query: 229 SDHLDQLKEIMKVTGTPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASP 282 D+ DQL I KV GT ++++ D ++ L + +K + + + + SP Sbjct: 252 QDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 311 Query: 283 LAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEP 321 A++LL+K+L D +QR+TA EA+ HPYF + + +P Sbjct: 312 EALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQP 350 >6O6Q-A nrPDB Length = 335 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 89/314 (28%), Positives = 163/314 (51%), Gaps = 40/314 (12%) Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80 W + Y L+ +G G Y V +D KV IK L +P + K+ RE+ +LK+ Sbjct: 37 WNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVL-KPVKR----KKIKREISILKN 91 Query: 81 MRH-ENVIGLLDVF------TPDETLDDFT--DFYLVMP-FMGTDLGKLMKHEKLGEDRI 130 + N+I +LDV TP + DF + P F D I Sbjct: 92 LVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYPTFTDYD--------------I 137 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLAR--QADSEMTGYVV 187 +F +Y++LK L Y H+ GI+HRD+KP N+ ++ D + L+++D+GLA +E V Sbjct: 138 RFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVA 197 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIMKVTGTPP 246 +R+++ PE+++++ Y ++D+WS GC++A M+ K F G + DQL +I++V G+ Sbjct: 198 SRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKN 257 Query: 247 -AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLVLDAEQRV 300 +++++ + Y + + K+ + + S ++L++++L D ++R+ Sbjct: 258 FKKYLEKYNISLGEEY-EDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERL 316 Query: 301 TAGEALAHPYFESL 314 TA EA+ H YF+ + Sbjct: 317 TAKEAMKHAYFDPI 330 >6EII-A nrPDB Length = 352 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 70/212 (33%), Positives = 124/212 (58%), Gaps = 12/212 (5%) Query: 113 GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILD 171 TD +L ++ L + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ E +L+++D Sbjct: 141 NTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 198 Query: 172 FGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKG 228 +GLA E V +R+++ PE+++++ Y ++D+WS+GC++A MI K F G Sbjct: 199 WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 258 Query: 229 SDHLDQLKEIMKVTGTPP-AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASP 282 D+ DQL I KV GT +++ + + + L +K + + + SP Sbjct: 259 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 318 Query: 283 LAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 A++ L+K+L D + R+TA EA+ HPYF ++ Sbjct: 319 EALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 350 >4MD7-E nrPDB Length = 391 Score = 121 bits (304), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 70/212 (33%), Positives = 124/212 (58%), Gaps = 12/212 (5%) Query: 113 GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILD 171 TD +L ++ L + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ E +L+++D Sbjct: 118 NTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLID 175 Query: 172 FGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK-TLFKG 228 +GLA E V +R+++ PE+++++ Y ++D+WS+GC++A MI K F G Sbjct: 176 WGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHG 235 Query: 229 SDHLDQLKEIMKVTGTPPA-EFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASP 282 D+ DQL I KV GT +++ + + + L +K + + + SP Sbjct: 236 HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 Query: 283 LAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 A++ L+K+L D + R+TA EA+ HPYF ++ Sbjct: 296 EALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 327 >3NCG-A nrPDB Length = 486 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 83/288 (28%), Positives = 141/288 (48%), Gaps = 44/288 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G++G V D T + A+K + + RE+ LLK + H N++ L ++ Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 93 FTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGII 150 L+D + FY+V + G +L +++K ++ E ++ Q+ G+ Y+H I+ Sbjct: 90 ------LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIV 143 Query: 151 HRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQ 205 HRDLKP N+ + +DC++KI+DFGL+ Q +++M + T +Y APEV+ Y + Sbjct: 144 HRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDE 201 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ-RLQSDEAKNYMKG 264 D+WS G I+ +++G F G + D LK + TG + Q R SD+AK Sbjct: 202 KCDVWSAGVILYILLSGTPPFYGKNEYDILKRVE--TGKYAFDLPQWRTISDDAK----- 254 Query: 265 LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 +L+ KML R+TA + L HP+ + Sbjct: 255 ---------------------DLIRKMLTFHPSLRITATQCLEHPWIQ 281 >2PVN-A nrPDB Length = 352 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 78/256 (30%), Positives = 137/256 (53%), Gaps = 37/256 (14%) Query: 85 NVIGLLDVF------TPDETLD--DFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQ 136 N++ LLD+ TP + + TDF ++ P L + I++ +Y+ Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYP-------------TLTDYDIRYYIYE 154 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDC-ELKILDFGLAR--QADSEMTGYVVTRWYRA 193 +LK L Y H+ GI+HRD+KP N+ ++ + +L+++D+GLA E V +R+++ Sbjct: 155 LLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKG 214 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIMKVTGTPP------ 246 PE++++ Y ++D+WS+GC+ A MI K F G D+ DQL +I KV GT Sbjct: 215 PELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLN 274 Query: 247 ---AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 E +L++ ++ K + D ++ SP A++ L+K+L D ++R+TA Sbjct: 275 KYRIELDPQLEALVGRHSRKPWLKFMNADNQHLV---SPEAIDFLDKLLRYDHQERLTAL 331 Query: 304 EALAHPYFESLHDTED 319 EA+ HPYF+ + E+ Sbjct: 332 EAMTHPYFQQVRAAEN 347 >3DFA-A nrPDB Length = 286 Score = 118 bits (296), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 84/294 (28%), Positives = 143/294 (48%), Gaps = 44/294 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y + +G G++G V D T + A+K + + RE+ LLK + H N+ Sbjct: 24 YNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNI 83 Query: 87 IGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L ++ L+D + FY+V + G +L +++K ++ E ++ Q+ G+ Y+ Sbjct: 84 MKLFEI------LEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYM 137 Query: 145 HAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILN 199 H I+HRDLKP N+ + +DC++KI+DFGL+ Q +++M + T +Y APEV+ Sbjct: 138 HKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG 197 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ-RLQSDEA 258 Y + D+WS G I+ +++G F G + D LK + TG + Q R SD+A Sbjct: 198 --TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVE--TGKYAFDLPQWRTISDDA 253 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 K +L+ KML R+TA + L HP+ + Sbjct: 254 K--------------------------DLIRKMLTFHPSLRITATQCLEHPWIQ 281 >3LIJ-A nrPDB Length = 494 Score = 118 bits (296), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 88/306 (28%), Positives = 151/306 (49%), Gaps = 42/306 (13%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 +T + +Y+ ++ +GSGAYG V D T + AIK + + S + E+ Sbjct: 28 ITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEV 87 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDLGKLMKHE-KLGEDRIQFL 133 +LK + H N++ L D F +D ++YLVM + G +L + H K E + Sbjct: 88 AVLKLLDHPNIMKLYDFF------EDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVI 141 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVT 188 + Q+L G+ Y+H I+HRDLKP NL + +D +KI+DFGL+ + +M + T Sbjct: 142 IKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGT 201 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 +Y APEV+ +Y + D+WS+G I+ ++ G F G + L+++ Sbjct: 202 AYYIAPEVLRK--KYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKV---------- 249 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 E Y PE + N S A +L+++ML D+++R++A +AL H Sbjct: 250 --------EKGKYTFDSPEWK---------NVSEGAKDLIKQMLQFDSQRRISAQQALEH 292 Query: 309 PYFESL 314 P+ + + Sbjct: 293 PWIKEM 298 >6FYV-A nrPDB Length = 337 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 90/328 (27%), Positives = 147/328 (44%), Gaps = 40/328 (12%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVD-GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 +RA Y + +G GA+G V +D G G VA+K + + + + A E+++L+H+ Sbjct: 12 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHL 68 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL---GEDRIQFLVYQML 138 + + E D +V +G +K D I+ + YQ+ Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 139 KGLRYIHAAGIIHRDLKPGN-LAVNED------------------CELKILDFGLARQAD 179 + + ++H + H DLKP N L V D ++K++DFG A D Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 188 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 + V TR YRAPEVIL + ++Q D+WS+GCI+ E G T+F+ D + L + Sbjct: 189 EHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 240 KVTGTPPAEFVQR-----------LQSDEAKNYMKGLPELEK--KDFASILTNASPLAVN 286 ++ G P +Q+ L DE + + + K K+F + Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD 307 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESL 314 L+ +ML D QR+T EAL HP+F+ L Sbjct: 308 LVRRMLEYDPTQRITLDEALQHPFFDLL 335 >2F57-A nrPDB Length = 317 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 83/286 (29%), Positives = 140/286 (48%), Gaps = 45/286 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKK--LYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G+ G VC A + TG +VA+KK L + + EL + E+ +++ H+NV+ + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELL----FNEVVIMRDYHHDNVVDMY 108 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 + + L ++VM F+ G L ++ H ++ E++I + +L+ L Y+H G+ Sbjct: 109 SSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGV 162 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYTQT 206 IHRD+K ++ + D +K+ DFG Q E+ V T ++ APEVI + + Y Sbjct: 163 IHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTE 221 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS+G ++ EMI G+ + PP + ++R++ LP Sbjct: 222 VDIWSLGIMVIEMIDGEPPY---------------FNEPPLQAMRRIRDS--------LP 258 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 K L S + L+ MLV + QR TA E L HP+ + Sbjct: 259 PRVKD-----LHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >5X8I-B nrPDB Length = 346 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 86/329 (26%), Positives = 145/329 (44%), Gaps = 42/329 (12%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 + A Y + +G GA+G V +D + G + K+ + + + + A E+++L+H+ Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK--NVDRYCEAARSEIQVLEHLN 68 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE---DRIQFLVYQMLK 139 + E + +V +G +K D I+ + YQ+ K Sbjct: 69 TTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 140 GLRYIHAAGIIHRDLKPGNLA---------------------VNEDCELKILDFGLARQA 178 + ++H+ + H DLKP N+ +N D +K++DFG A Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPD--IKVVDFGSATYD 186 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 D + V TR YRAPEVIL + ++Q D+WS+GCI+ E G T+F D + L + Sbjct: 187 DEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMM 245 Query: 239 MKVTGTPPAEFVQ-----------RLQSDEAKNYMKGLPELEK--KDFASILTNASPLAV 285 ++ G P +Q RL DE + + + K K+F Sbjct: 246 ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLF 305 Query: 286 NLLEKMLVLDAEQRVTAGEALAHPYFESL 314 +L++KML D +R+T EAL HP+F+ L Sbjct: 306 DLIQKMLEYDPAKRITLREALKHPFFDLL 334 >2YCR-A nrPDB Length = 323 Score = 114 bits (286), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 95/321 (29%), Positives = 154/321 (47%), Gaps = 54/321 (16%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA------YRELRLLKHMRHE 84 + +GSGA G V A + +T KVAIK + + + A+ A E+ +LK + H Sbjct: 16 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 75 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 +I + + F D D+Y+V+ M G K++ +++L E + YQML ++ Sbjct: 76 CIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 128 Query: 143 YIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVI 197 Y+H GIIHRDLKP N+ ++ EDC +KI DFG ++ S M T Y APEV+ Sbjct: 129 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVL 188 Query: 198 LN--WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 ++ Y + VD WS+G I+ ++G F S+H Q+ L+ Sbjct: 189 VSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVS----------------LKD 230 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 +PE + S A++L++K+LV+D + R T EAL HP+ Sbjct: 231 QITSGKYNFIPE--------VWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL---- 278 Query: 316 DTEDEPQVQKYDDSFDDVDRT 336 +DE +K+ D + + + Sbjct: 279 --QDEDMKRKFQDLLSEENES 297 >4FIE-A nrPDB Length = 423 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 45/285 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKK--LYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G+ G VC A +G VA+KK L + + EL + E+ +++ +HENV+ + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELL----FNEVVIMRDYQHENVVEMY 214 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 + + + L ++VM F+ G L ++ H ++ E++I + +L+ L +HA G+ Sbjct: 215 NSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 268 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVILNWMRYTQT 206 IHRD+K ++ + D +K+ DFG Q E+ V T ++ APE+I + + Y Sbjct: 269 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPE 327 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS+G ++ EM+ G+ + L +K I PP RL++ Sbjct: 328 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD--NLPP-----RLKN----------- 369 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 L SP L+++LV D QR TA E L HP+ Sbjct: 370 ----------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >4XBR-A nrPDB Length = 366 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 45/285 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKK--LYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G+ G VC A +G VA+KK L + + EL + E+ +++ +HENV+ + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELL----FNEVVIMRDYQHENVVEMY 157 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 + + + L ++VM F+ G L ++ H ++ E++I + +L+ L +HA G+ Sbjct: 158 NSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 211 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYTQT 206 IHRD+K ++ + D +K+ DFG Q E+ V T ++ APE+I + + Y Sbjct: 212 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPE 270 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS+G ++ EM+ G+ + L +K I PP RL++ Sbjct: 271 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD--NLPP-----RLKN----------- 312 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 L SP L+++LV D QR TA E L HP+ Sbjct: 313 ----------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >2Q0N-A nrPDB Length = 301 Score = 114 bits (284), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 45/285 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKK--LYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G+ G VC A +G VA+KK L + + EL + E+ +++ +HENV+ + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELL----FNEVVIMRDYQHENVVEMY 92 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 + + + L ++VM F+ G L ++ H ++ E++I + +L+ L +HA G+ Sbjct: 93 NSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 146 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYTQT 206 IHRD+K ++ + D +K+ DFG Q E+ V T ++ APE+I + + Y Sbjct: 147 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPE 205 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS+G ++ EM+ G+ + L +K I PP RL++ Sbjct: 206 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD--NLPP-----RLKN----------- 247 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 L SP L+++LV D QR TA E L HP+ Sbjct: 248 ----------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >3COM-A nrPDB Length = 314 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 86/295 (29%), Positives = 142/295 (48%), Gaps = 47/295 (15%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 V+ L+ +G G+YG+V A+ TG VAIK++ P +S+L + +E+ +++ + Sbjct: 30 VFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV--PVESDL--QEIIKEISIMQQCDSPH 85 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 V+ + + TD ++VM + G +D+ +L +++ L ED I ++ LKGL Sbjct: 86 VVKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRL-RNKTLTEDEIATILQSTLKGL 138 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVIL 198 Y+H IHRD+K GN+ +N + K+ DFG+A Q M + T ++ APEVI Sbjct: 139 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 198 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + Y DIWS+G EM GK + + ++ I + PP F + Sbjct: 199 E-IGYNCVADIWSLGITAIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK------- 247 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 PEL +F + +++ LV EQR TA + L HP+ S Sbjct: 248 -------PELWSDNFT-----------DFVKQCLVKSPEQRATATQLLQHPFVRS 284 >3I6U-A nrPDB Length = 419 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 96/317 (30%), Positives = 149/317 (47%), Gaps = 62/317 (19%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE----------LRLLKH 80 + +GSGA G V A + +T KVAI R FA + RE + +LK Sbjct: 141 KTLGSGACGEVKLAFERKTCKKVAI----RIISKRKFAIGSAREADPALNVETEIEILKK 196 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQML 138 + H +I + + F D D+Y+V+ M G K++ +++L E + YQML Sbjct: 197 LNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 249 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLAR--QADSEMTGYVVTRWYRA 193 ++Y+H GIIHRDLKP N+ ++ EDC +KI DFG ++ S M T Y A Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLA 309 Query: 194 PEVILN--WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 PEV+++ Y + VD WS+G I+ ++G F S+H Q+ Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVS--------------- 352 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 L+ +PE + S A++L++K+LV+D + R T EAL HP+ Sbjct: 353 -LKDQITSGKYNFIPE--------VWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 403 Query: 312 ESLHDTEDEPQVQKYDD 328 +DE +K+ D Sbjct: 404 ------QDEDMKRKFQD 414 >4JDH-A nrPDB Length = 346 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 45/285 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKK--LYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G+ G VC A +G VA+KK L + + EL + E+ +++ +HENV+ + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELL----FNEVVIMRDYQHENVVEMY 137 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 + + + L ++VM F+ G L ++ H ++ E++I + +L+ L +HA G+ Sbjct: 138 NSYLVGDEL------WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGV 191 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYTQT 206 IHRD+K ++ + D +K+ DFG Q E+ V T ++ APE+I + + Y Sbjct: 192 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPE 250 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS+G ++ EM+ G+ + L +K I PP RL++ Sbjct: 251 VDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD--NLPP-----RLKN----------- 292 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 L SP L+++LV D QR TA E L HP+ Sbjct: 293 ----------LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >6AO5-A nrPDB Length = 362 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 143/295 (48%), Gaps = 47/295 (15%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 V+ L+ +G G+YG+V A+ +G VAIK++ P +S+L + +E+ +++ Sbjct: 11 VFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSPY 66 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 V+ + + TD ++VM + G +D+ +L +++ L ED I ++ LKGL Sbjct: 67 VVKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKSTLKGL 119 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVIL 198 Y+H IHR++K GN+ +N + K+ DFG+A Q M + T ++ APEVI Sbjct: 120 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 179 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + Y DIWS+G EM GK + + ++ I + PP F + Sbjct: 180 E-IGYNCVADIWSLGITSIEMAEGKPPYAD---IHPMRAIFMIPTNPPPTFRK------- 228 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 PEL DF + ++K LV + EQR TA + L HP+ ++ Sbjct: 229 -------PELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN 265 >4IAN-A nrPDB Length = 358 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 101/350 (28%), Positives = 162/350 (46%), Gaps = 65/350 (18%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDG-RTGAKVAIKKLYRPFQSELFA 68 G+YR + + + VY G G + V A D R +VA+K + +EL Sbjct: 18 GYYRVNIGEVLDKRYNVY---GYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQ 71 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDE---TLDDFTDFY------LVMPFMGTDLGKL 119 K +EL LK + + PD+ L F FY LV + +L ++ Sbjct: 72 KTGLKELEFLKKLNDAD---------PDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREV 122 Query: 120 MKHEKLGED------RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED-CELKILDF 172 +K K G+D ++ Q+ L+ + I+H D+KP N+ VNE LK+ DF Sbjct: 123 LK--KYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDF 180 Query: 173 GLARQ-ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDH 231 G A AD+++T Y+V+R+YRAPE+I+ Y +D+WSVGC + E+ TGK LF G + Sbjct: 181 GSASHVADNDITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTN 239 Query: 232 LDQLKEIMKVTGTPPAEFVQR-----LQSDEAKNYM----KGLPELEK----------KD 272 LK M + G P + +++ D+ N+M + E EK KD Sbjct: 240 NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKD 299 Query: 273 FASILTNASPL----------AVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + L L +LL+++L+LD +R++ +AL H + + Sbjct: 300 LLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 349 >4RGJ-A nrPDB Length = 520 Score = 112 bits (279), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 85/297 (28%), Positives = 149/297 (50%), Gaps = 44/297 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHEN 85 Y+ ++ +G G++G V + D TG + AIK + + K + RE+ LLK + H N Sbjct: 62 YKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHIN 121 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L + F +D +YLV + G +L +++ ++ E ++ Q+L G+ Y Sbjct: 122 IMKLYEFF------EDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITY 175 Query: 144 IHAAGIIHRDLKPGNLAV----NEDCELKILDFGLARQAD--SEMTGYVVTRWYRAPEVI 197 +H ++HRDLKP N+ + ED +KI+DFGL+ + +M + T +Y AP+V+ Sbjct: 176 MHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL 235 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 Y + DIWS G I+ +++G F GS+ D LK++ E Sbjct: 236 HG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------------------E 275 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 A Y LP+ +K S A +L++KML+ + R++A +AL H + + + Sbjct: 276 AGKYTFDLPQFKK---------ISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMM 323 >3MA6-A nrPDB Length = 298 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 84/295 (28%), Positives = 147/295 (49%), Gaps = 43/295 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-RPFQSELFAKRAYRELRLLKHMRHEN 85 Y+ + +G G++G V D TG + A+K + R + + + RE++LLK + H N Sbjct: 34 YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPN 93 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L + F +D FYLV + G +L +++ ++ E ++ Q+L G+ Y Sbjct: 94 IMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITY 147 Query: 144 IHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVIL 198 +H I+HRDLKP NL + ++D ++I+DFGL+ +A +M + T +Y APEV+ Sbjct: 148 MHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLH 207 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y + D+WS G I+ +++G F G++ D LK++ E Sbjct: 208 G--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV------------------EK 247 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Y LP+ +K S A +L+ KML R++A +AL H + ++ Sbjct: 248 GKYTFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQT 293 >4LFI-A nrPDB Length = 374 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 137/251 (54%), Gaps = 33/251 (13%) Query: 80 HMRHENVIGLLDVF------TPDETLD--DFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ 131 H H N+I L D+ TP + D DF ++ P KL + I+ Sbjct: 129 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP-------------KLTDLEIR 175 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QADSEMTGYVVT 188 F ++++LK L Y H+ GI+HRD+KP N+ ++ ++ +L+++D+GLA + E V + Sbjct: 176 FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS 235 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIMKVTGTPPA 247 R+++ PE+++++ Y ++D+WS G ++A MI + F G+ + DQL +I+KV GT Sbjct: 236 RFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDF 295 Query: 248 E-FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL------AVNLLEKMLVLDAEQRV 300 E ++ + + + + + + +K + + + + ++L++ +L D ++R+ Sbjct: 296 EKYLLKYEITLPREFY-DMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL 354 Query: 301 TAGEALAHPYF 311 TA EA+ HP+F Sbjct: 355 TAKEAMGHPWF 365 >4LG4-A nrPDB Length = 299 Score = 111 bits (278), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 143/295 (48%), Gaps = 47/295 (15%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 V+ L+ +G G+YG+V A+ +G VAIK++ P +S+L + +E+ +++ Sbjct: 12 VFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV--PVESDL--QEIIKEISIMQQCDSPY 67 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 V+ + + TD ++VM + G +D+ +L +++ L ED I ++ LKGL Sbjct: 68 VVKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKSTLKGL 120 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVIL 198 Y+H IHR++K GN+ +N + K+ DFG+A Q M + T ++ APEVI Sbjct: 121 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 180 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + Y DIWS+G EM GK + + ++ I + PP F + Sbjct: 181 E-IGYNCVADIWSLGITSIEMAEGKPPYA---DIHPMRAIFMIPTNPPPTFRK------- 229 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 PEL DF + ++K LV + EQR TA + L HP+ ++ Sbjct: 230 -------PELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN 266 >5JN2-A nrPDB Length = 525 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 84/295 (28%), Positives = 147/295 (49%), Gaps = 43/295 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-RPFQSELFAKRAYRELRLLKHMRHEN 85 Y+ + +G G++G V D TG + A+K + R + + + RE++LLK + H N Sbjct: 69 YKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPN 128 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L + F +D FYLV + G +L +++ ++ E ++ Q+L G+ Y Sbjct: 129 IMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITY 182 Query: 144 IHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVIL 198 +H I+HRDLKP NL + ++D ++I+DFGL+ +A +M + T +Y APEV+ Sbjct: 183 MHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLH 242 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y + D+WS G I+ +++G F G++ D LK++ E Sbjct: 243 G--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV------------------EK 282 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Y LP+ +K S A +L+ KML R++A +AL H + ++ Sbjct: 283 GKYTFELPQWKK---------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQT 328 >5UNP-A nrPDB Length = 369 Score = 111 bits (277), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 92/349 (26%), Positives = 159/349 (45%), Gaps = 59/349 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTG-AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y + +G G +G V VD R G A+VA+K + E + + A E+ +L+ + ++ Sbjct: 36 YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINEKD 92 Query: 86 ------VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE---DRIQFLVYQ 136 + + D F D + +G +K +++ + +Q Sbjct: 93 PDNKNLCVQMFDWF------DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQ 146 Query: 137 MLKGLRYIHAAGIIHRDLKPGN-LAVNEDCEL------------------KILDFGLARQ 177 + + ++++H + H DLKP N L VN D EL +++DFG A Sbjct: 147 LCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF 206 Query: 178 ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 + V TR YRAPEVIL + ++Q D+WS+GCI+ E G TLF+ D+ + L Sbjct: 207 DHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFAS--ILTNASPLA----------- 284 + ++ G P+ +++ + + K + +G + ++ A + N PL Sbjct: 266 MERILGPIPSRMIRKTR--KQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHH 323 Query: 285 --VNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFD 331 +L+E ML + +R+T GEAL HP+F L EP + +D S D Sbjct: 324 QLFDLIESMLEYEPAKRLTLGEALQHPFFARL---RAEPPNKLWDSSRD 369 >4KS7-A nrPDB Length = 292 Score = 110 bits (276), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 81/285 (28%), Positives = 141/285 (49%), Gaps = 45/285 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK--KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G+ G VC A + +G +VA+K L + + EL + E+ +++ +H NV+ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELL----FNEVVIMRDYQHFNVVEMY 86 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 + E L +++M F+ G L ++ +L E++I + +L+ L Y+HA G+ Sbjct: 87 KSYLVGEEL------WVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGV 140 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYTQT 206 IHRD+K ++ + D +K+ DFG Q ++ V T ++ APEVI + Y Sbjct: 141 IHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL-YATE 199 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS+G ++ EM+ G+ + + +K ++ +PP + KN K Sbjct: 200 VDIWSLGIMVIEMVDGEPPYFSDSPVQAMK---RLRDSPPPKL---------KNSHK--- 244 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 SP+ + LE+MLV D ++R TA E L HP+ Sbjct: 245 -------------VSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >3RAW-A nrPDB Length = 381 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 96/331 (29%), Positives = 146/331 (44%), Gaps = 54/331 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVD-GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y + +G G +G V +D R ++VA+K + + A+ L+ +K EN Sbjct: 53 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKEN 112 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ--------FLVYQM 137 L V + D+ +F+ M LGK E L E+ Q + YQ+ Sbjct: 113 --KFLCVL-----MSDWFNFHGHMCIAFELLGK-NTFEFLKENNFQPYPLPHVRHMAYQL 164 Query: 138 LKGLRYIHAAGIIHRDLKPGN-LAVNED----------CE--------LKILDFGLARQA 178 LR++H + H DLKP N L VN + CE +++ DFG A Sbjct: 165 CHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFD 224 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 T V TR YR PEVIL + + Q D+WS+GCI+ E G TLF+ ++ + L + Sbjct: 225 HEHHTTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMM 283 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKG--LPELEKKDFASILTNASPLA------------ 284 K+ G P+ + R + + K + KG + + D + N PL Sbjct: 284 EKILGPIPSHMIHR--TRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQ 341 Query: 285 -VNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 +L+ +ML D QR+T EAL HP+F L Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFFAGL 372 >3Q5I-A nrPDB Length = 504 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 92/309 (29%), Positives = 140/309 (45%), Gaps = 53/309 (17%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAV--CSAVDGRTGAKVAIKKLYRPFQS--------- 64 V K ++ Y ++ +GSGAYG V C +G + + + K + + Sbjct: 27 VRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNI 86 Query: 65 ELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKH 122 E F + Y E+ LLK + H N+I L DVF +D FYLV F G +++ Sbjct: 87 EKFHEEIYNEISLLKSLDHPNIIKLFDVF------EDKKYFYLVTEFYEGGELFEQIINR 140 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--Q 177 K E ++ Q+L G+ Y+H I+HRD+KP N+ + N +KI+DFGL+ Sbjct: 141 HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFS 200 Query: 178 ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 D ++ + T +Y APEV+ +Y + D+WS G IM ++ G F G + D +K+ Sbjct: 201 KDYKLRDRLGTAYYIAPEVLKK--KYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKK 258 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 + K K Y DF N S A L++ ML D Sbjct: 259 VEK-----------------GKYYF---------DFND-WKNISDEAKELIKLMLTYDYN 291 Query: 298 QRVTAGEAL 306 +R TA EAL Sbjct: 292 KRCTAEEAL 300 >3DXN-A nrPDB Length = 287 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 89/294 (30%), Positives = 145/294 (49%), Gaps = 45/294 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHEN 85 Y+ ++ +GSGAYG V D TGA+ AIK + + + A E+ +LK + H N Sbjct: 23 YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN 82 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L + F +D ++YLVM + G +L +++ +K E ++ Q+L G Y Sbjct: 83 IMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTY 136 Query: 144 IHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVIL 198 +H I+HRDLKP NL + + D +KI+DFGL+ + +M + T +Y APEV+ Sbjct: 137 LHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR 196 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT-PPAEFVQRLQSDE 257 +Y + D+WS G I+ ++ G F G + LK + K + P ++ Q SDE Sbjct: 197 K--KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQ--VSDE 252 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 AK L++ ML + +R++A EAL HP+ Sbjct: 253 AKQ--------------------------LVKLMLTYEPSKRISAEEALNHPWI 280 >5XZW-A nrPDB Length = 471 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 96/318 (30%), Positives = 149/318 (46%), Gaps = 74/318 (23%) Query: 25 AVYRDL----QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR--------AY 72 +++D + VG GA+ V A++ TG A+K + +KR Sbjct: 192 GIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVK---------IISKRKVIGNMDGVT 242 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-HEKLGEDRI 130 REL +L+ + H ++ L + +D +Y+VM F+ G DL + H +GED Sbjct: 243 RELEVLQKLNHPRIVRLKGFY------EDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG 296 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED--CELKILDFGLAR-QAD-SEMTGYV 186 + + Q+L ++YIH+ GI HRDLKP N+ + +D +KI DFGLA+ Q + S M + Sbjct: 297 REISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFC 356 Query: 187 VTRWYRAPEVILN------------WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 T Y APEVI Y+ VD+WS+GC++ ++TG F GS DQ Sbjct: 357 GTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQ 415 Query: 235 L-KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 L K+I + +Y +G KDF S A + ++ +L Sbjct: 416 LYKQIGR------------------GSYHEG----PLKDF-----RISEEARDFIDSLLQ 448 Query: 294 LDAEQRVTAGEALAHPYF 311 +D R TA +AL HP+ Sbjct: 449 VDPNNRSTAAKALNHPWI 466 >3HZT-A nrPDB Length = 467 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 89/294 (30%), Positives = 145/294 (49%), Gaps = 45/294 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHEN 85 Y+ ++ +GSGAYG V D TGA+ AIK + + + A E+ +LK + H N Sbjct: 6 YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN 65 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L + F +D ++YLVM + G +L +++ +K E ++ Q+L G Y Sbjct: 66 IMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTY 119 Query: 144 IHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVIL 198 +H I+HRDLKP NL + + D +KI+DFGL+ + +M + T +Y APEV+ Sbjct: 120 LHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR 179 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT-PPAEFVQRLQSDE 257 +Y + D+WS G I+ ++ G F G + LK + K + P ++ Q SDE Sbjct: 180 K--KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQV--SDE 235 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 AK L++ ML + +R++A EAL HP+ Sbjct: 236 AKQ--------------------------LVKLMLTYEPSKRISAEEALNHPWI 263 >2WO6-A nrPDB Length = 382 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 76/243 (31%), Positives = 125/243 (51%), Gaps = 15/243 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLD 91 +G G++G V A D VAIK + + F +A E+RLL+ M +H+ + Sbjct: 62 IGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEVRLLELMNKHDTEMKYYI 118 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF---LVYQMLKGLRYIHAA- 147 V + LV + +L L+++ + QM L ++ Sbjct: 119 VHLKRHFMFR-NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPE 177 Query: 148 -GIIHRDLKPGN--LAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT 204 IIH DLKP N L + +KI+DFG + Q + Y+ +R+YR+PEV+L M Y Sbjct: 178 LSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG-MPYD 236 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 +D+WS+GCI+ EM TG+ LF G++ +DQ+ +I++V G PPA + Q+ +A+ + + Sbjct: 237 LAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILD--QAPKARKFFEK 294 Query: 265 LPE 267 LP+ Sbjct: 295 LPD 297 >4PDS-A nrPDB Length = 347 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 94/342 (27%), Positives = 152/342 (44%), Gaps = 72/342 (21%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDL----QPVGSGAYGAVCSAVDGRTGAKVAIK 56 M++ A G + +++D + VG GA+ V A++ TG Sbjct: 3 MATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTG------ 56 Query: 57 KLYRPFQSELFAKR--------AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLV 108 + F ++ +KR REL +L+ + H ++ L + +D +Y+V Sbjct: 57 ---KTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY------EDTESYYMV 107 Query: 109 MPFM-GTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED-- 164 M F+ G DL + H +GED + + Q+L ++YIH+ GI HRDLKP N+ + +D Sbjct: 108 MEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP 167 Query: 165 CELKILDFGLAR-QAD-SEMTGYVVTRWYRAPEVILN------------WMRYTQTVDIW 210 +KI FGLA+ Q + S M + T Y APEVI Y+ VD+W Sbjct: 168 VLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMW 227 Query: 211 SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 S+GC++ ++TG F GS K+I + +Y +G Sbjct: 228 SMGCLVYVILTGHLPFSGSTQDQLYKQIGR------------------GSYHEG----PL 265 Query: 271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 KDF S A + ++ +L +D R TA +AL HP+ + Sbjct: 266 KDF-----RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >4NIF-A nrPDB Length = 333 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 99/340 (29%), Positives = 154/340 (45%), Gaps = 60/340 (17%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR--LLKHMRHENVIG 88 + +G G+Y V T + A+K + + +KR E LL++ +H N+I Sbjct: 14 ETIGVGSYSECKRCVHKATNMEYAVKVIDK-------SKRDPSEEIEILLRYGQHPNIIT 66 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 L DV+ DD YLV M G L K+++ + E F+++ + K + Y+H+ Sbjct: 67 LKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 120 Query: 147 AGIIHRDLKPGNL-----AVNEDCELKILDFGLARQADSEMTGYVVTRWYR----APEVI 197 G++HRDLKP N+ + N +C L+I DFG A+Q +E G ++T Y APEV Sbjct: 121 QGVVHRDLKPSNILYVDESGNPEC-LRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEV- 177 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L Y + DIWS+G ++ M+ G T F P E + R+ S Sbjct: 178 LKRQGYDEGCDIWSLGILLYTMLAGYTPFANG------------PSDTPEEILTRIGS-- 223 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 G L ++ ++ S A +L+ KML +D QR+TA + L HP+ + Sbjct: 224 ------GKFTLSGGNWNTV----SETAKDLVSKMLHVDPHQRLTAKQVLQHPW---VTQK 270 Query: 318 EDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQL 357 + PQ Q V + TY + S KP QL Sbjct: 271 DKLPQSQLSHQDLQLVKGAM----AATYSALNSSKPTPQL 306 >3D2K-A nrPDB Length = 272 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 79/287 (27%), Positives = 133/287 (46%), Gaps = 42/287 (14%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRHENVIGL 89 +P+G G +G V A + ++ +A+K L++ + + RE+ + H+RH N++ L Sbjct: 18 RPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRL 77 Query: 90 LDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 F D T YL++ + +GT +L K + E R + ++ L Y H+ Sbjct: 78 YGYF------HDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSK 131 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRWYRAPEVILNWMRYTQT 206 +IHRD+KP NL + + ELKI DFG + A S T T Y PE+I M + + Sbjct: 132 RVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM-HDEK 190 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VD+WS+G + E + G F+ + + + I +V T P Sbjct: 191 VDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP-------------------- 230 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 DF + A +L+ ++L +A QR+T E L HP+ ++ Sbjct: 231 -----DF------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKA 266 >4MVF-A nrPDB Length = 506 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 80/291 (27%), Positives = 136/291 (46%), Gaps = 44/291 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G G YG V +D T AIK+ + + R ++E+ ++K + H N++ L Sbjct: 63 EKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI--NRFFQEIEIMKKLDHPNIVKLY 120 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 + + D + YL+M G +L ++++ E ++ Q+ + Y+H+ Sbjct: 121 ETYENDNYI------YLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLN 174 Query: 149 IIHRDLKPGNL---AVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRY 203 I+HRDLKP N + N+D LKI+DFGL++ + T T +Y AP+V+ +Y Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG--KY 232 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK 263 + DIWS G IM ++ G F G + LK++ K EF Sbjct: 233 DKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKK------GEFC------------- 273 Query: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 + D+ SI ++A NL+ K+L + +R T EAL HP+ + Sbjct: 274 ----FYENDWGSISSDAK----NLITKLLTYNPNERCTIEEALNHPWITQM 316 >4UZD-A nrPDB Length = 287 Score = 104 bits (259), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 74/240 (30%), Positives = 118/240 (49%), Gaps = 12/240 (5%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRHENVIGL 89 +P+G G +G V A + ++ +A+K L++ + + RE+ + H+RH N++ L Sbjct: 14 RPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRL 73 Query: 90 LDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 F D T YL++ + +GT +L K K E R + ++ L Y H+ Sbjct: 74 YGYF------HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSK 127 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRWYRAPEVILNWMRYTQT 206 +IHRD+KP NL + ELKI DFG + A S T T Y PE+I M + + Sbjct: 128 RVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRM-HDEK 186 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VD+WS+G + E + GK F+ + + + K I +V T P +FV D +K P Sbjct: 187 VDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFP-DFVTEGARDLISRLLKHNP 245 >4FG9-A nrPDB Length = 320 Score = 103 bits (258), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 87/303 (28%), Positives = 146/303 (48%), Gaps = 46/303 (15%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--REL 75 K A ++R +Y +G+GA+ V A D RT VAIK + + L K E+ Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAK---EALEGKEGSMENEI 67 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFL 133 +L ++H N++ L D++ L YL+M + G ++++ E L Sbjct: 68 AVLHKIKHPNIVALDDIYESGGHL------YLIMQLVSGGELFDRIVEKGFYTERDASRL 121 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNL---AVNEDCELKILDFGLARQAD--SEMTGYVVT 188 ++Q+L ++Y+H GI+HRDLKP NL +++ED ++ I DFGL++ D S ++ T Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGT 181 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 Y APEV L Y++ VD WS+G I ++ G F + ++I+K + Sbjct: 182 PGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 240 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 + + SD AK++++ +L+EK D E+R T +AL H Sbjct: 241 YWDDI-SDSAKDFIR----------------------HLMEK----DPEKRFTCEQALQH 273 Query: 309 PYF 311 P+ Sbjct: 274 PWI 276 >3IS5-A nrPDB Length = 285 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 140/293 (47%), Gaps = 52/293 (17%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +GSGA+G V + +G + IK + + +S++ ++ E+ +LK + H N+I + +V Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHPNIIKIFEV 88 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKH--------EKLGEDRIQFLVYQMLKGLRYI 144 F +D+ + Y+VM + G+L++ + L E + L+ QM+ L Y Sbjct: 89 F------EDYHNMYIVME--TCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYF 140 Query: 145 HAAGIIHRDLKPGNLAVNE---DCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILN 199 H+ ++H+DLKP N+ + +KI+DFGLA ++D T T Y APEV Sbjct: 141 HSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKR 200 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + + DIWS G +M ++TG F TGT E Q+ E Sbjct: 201 DVTF--KCDIWSAGVVMYFLLTGCLPF---------------TGTSLEEVQQKATYKEPN 243 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 ++ P +P AV+LL++ML D E+R +A + L H +F+ Sbjct: 244 YAVECRP-------------LTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >4C0T-A nrPDB Length = 974 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 80/316 (25%), Positives = 147/316 (46%), Gaps = 62/316 (19%) Query: 22 EVRAVYRDL------QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 E++ + R++ + +G G+Y V A D TG + A+K L + + ++ + + Sbjct: 257 EMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDK---RHIIKEKKVKYV 313 Query: 76 RLLKHM--RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQ 131 + KH R N +G++ ++ T D Y V+ + G L + ++ L E+ + Sbjct: 314 NIEKHALNRLSNRLGVISLYF---TFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTR 370 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR------------QAD 179 Q+L ++Y+H G+IHRDLKP N+ +++ ++I DFG AR D Sbjct: 371 HFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVD 430 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYT-QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 +V T Y +PE++ N +Y + D+W+ GCI+ +MI GK FK ++ ++I Sbjct: 431 VRAKSFVGTAEYVSPELLEN--KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKI 488 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 K+ +F + G P + + +L++K+LVL + Sbjct: 489 TKL------QFA----------FSAGFPTIIR---------------DLIKKILVLQPSR 517 Query: 299 RVTAGEALAHPYFESL 314 R T E H +F+S+ Sbjct: 518 RATIPEIQKHYFFQSV 533 >2JAM-A nrPDB Length = 304 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 83/297 (27%), Positives = 140/297 (47%), Gaps = 44/297 (14%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHM 81 +R + ++ +GSGA+ V TG A+K + + S F + E+ +LK + Sbjct: 7 IRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK---SPAFRDSSLENEIAVLKKI 63 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 +HEN++ L D++ + T +YLVM + G ++++ E ++ Q+L Sbjct: 64 KHENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLS 117 Query: 140 GLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR-QADSEMTGYVVTRWYRAPE 195 ++Y+H GI+HRDLKP NL E+ ++ I DFGL++ + + M+ T Y APE Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPE 177 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 V L Y++ VD WS+G I ++ G PP F + +S Sbjct: 178 V-LAQKPYSKAVDCWSIGVITYILL---------------------CGYPP--FYEETES 213 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + +G E E + I +A +LLEK D +R T +AL+HP+ + Sbjct: 214 KLFEKIKEGYYEFESPFWDDISESAKDFICHLLEK----DPNERYTCEKALSHPWID 266 >3ORZ-A nrPDB Length = 316 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 135/298 (45%), Gaps = 56/298 (18%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G++ V A + T + AIK L R E RE ++ + H + L Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 104 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLG---EDRIQFLVYQMLKGLRYIHAA 147 F DE L Y + + G+L+K+ K+G E +F +++ L Y+H Sbjct: 105 CFQDDEKL------YFGLSYAKN--GELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 156 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-----MTGYVVTRWYRAPEVILNWMR 202 GIIHRDLKP N+ +NED ++I DFG A+ E +V T Y +PE +L Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LLTEKS 215 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 ++ D+W++GCI+ +++ G F+ + ++I+K+ P +F Sbjct: 216 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFF------------ 263 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA------GEALAHPYFESL 314 P A +L+EK+LVLDA +R+ G AHP+FES+ Sbjct: 264 -------------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 302 >6FD3-A nrPDB Length = 300 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 138/290 (47%), Gaps = 41/290 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y + +G GA G V +A+D TG +VAIK++ Q + + E+ +++ ++ N+ Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVMRENKNPNI 81 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 + LD + + L ++VM ++ G L ++ + E +I + + L+ L ++H Sbjct: 82 VNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLH 135 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNWMR 202 + +IHRD+K N+ + D +K+ DFG Q S+ + V T ++ APEV+ Sbjct: 136 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KA 194 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 Y VDIWS+G + EM+ G+ + + L L ++ GTP + +RL Sbjct: 195 YGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALY-LIATNGTPELQNPERL--------- 244 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S + + L + L +D ++R +A E L HP+ + Sbjct: 245 ------------------SAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >5ES1-A nrPDB Length = 328 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 65/215 (30%), Positives = 112/215 (52%), Gaps = 11/215 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR L+ +G G + V A TG +VAIK + + + ++ +RE+R++K + H N+ Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 76 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L +V ++TL YLVM + G L+ H ++ E + Q++ + Y Sbjct: 77 VKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 130 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWMR 202 H I+HRDLK NL ++ + +KI DFG + + S++ + + Y APE+ Sbjct: 131 HQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKY 190 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 VDIWS+G I+ +++G F G + L +L+E Sbjct: 191 DGPEVDIWSLGVILYTLVSGSLPFDGHN-LKELRE 224 >3H4J-B nrPDB Length = 336 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 81/286 (28%), Positives = 133/286 (46%), Gaps = 43/286 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF--QSELFAKRAYRELRLLKHMRHENVIG 88 + +G G++G V A +T KVA+K + R +S++ R RE+ LK +RH ++I Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHM-RVEREISYLKLLRHPHIIK 73 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 L DV T TD +V+ + G +L +++ +++ ED + Q++ + Y H Sbjct: 74 LYDVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQ 205 I+HRDLKP NL ++++ +KI DFGL+ D + + Y APEVI + Sbjct: 128 KIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 VD+WS G ++ M+ G+ F + K++ P Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMP------------------- 228 Query: 266 PELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 DF SP A +L+ +M+V D QR+T E P+F Sbjct: 229 ------DF------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 >6E2O-A nrPDB Length = 295 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 66/203 (32%), Positives = 108/203 (53%), Gaps = 16/203 (7%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G YG V + D ++AIK++ P + +++ + E+ L KH++H+N++ L Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAAG 148 F+ + + F + +P G L L++ + K E I F Q+L+GL+Y+H Sbjct: 88 FSENGFIKIFME---QVP--GGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQ 142 Query: 149 IIHRDLKPGNLAVNE-DCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVILNWMR-Y 203 I+HRD+K N+ +N LKI DFG +++ + + T Y APE+I R Y Sbjct: 143 IVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGY 202 Query: 204 TQTVDIWSVGCIMAEMITGKTLF 226 + DIWS+GC + EM TGK F Sbjct: 203 GKAADIWSLGCTIIEMATGKPPF 225 >2HW6-A nrPDB Length = 307 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 86/304 (28%), Positives = 140/304 (46%), Gaps = 48/304 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLD 91 +G GAY V AV + G + A+K + + Q+ R +RE+ L + ++N++ L++ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 92 VFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 F +D T FYLV + G+ L + K + E +V + L ++H GI Sbjct: 79 FF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 150 IHRDLKPGNLAVNEDCE-------LKILDFGLARQ----------ADSEMTGYVVTRWYR 192 HRDLKP N+ CE +KI DF L E+T + Y Sbjct: 133 AHRDLKPENIL----CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 193 APEVILNWMR----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 APEV+ + Y + D+WS+G ++ M++G F G D G E Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--------CGWDRGE 240 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 + Q+ ++ +G E KD+A I + A +L+ K+LV DA+QR++A + L H Sbjct: 241 VCRVCQNKLFESIQEGKYEFPDKDWAHISSEAK----DLISKLLVRDAKQRLSAAQVLQH 296 Query: 309 PYFE 312 P+ + Sbjct: 297 PWVQ 300 >4CZT-A nrPDB Length = 464 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 84/318 (26%), Positives = 140/318 (44%), Gaps = 50/318 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKL--YRPFQSELFAKRAYRELRLLKHMRHENVIG 88 + +G G + V A + G VAIK + + ++++ A + RE+ +K ++H NVI Sbjct: 17 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIA-QIKREISTMKLIKHPNVIR 75 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 + +V T Y V+ F+ G K+ + +L ED + Q++ + Y H+ Sbjct: 76 MFEVMASK------TKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLAR-----QADSEMTGYVVTRWYRAPEVILNWM 201 G+ HRDLKP NL ++ + LK+ DFGL+ + D + T Y APEVI N Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 D+WS G I+ ++ G F+ S+ K+I K T P F Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------------ 237 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEP 321 S A L++++L + R+T E + + +F+ + P Sbjct: 238 -------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKA---P 275 Query: 322 QVQKYDDSFDDVDRTLDE 339 + + D S DDVD D+ Sbjct: 276 KFENADVSLDDVDAIFDD 293 >5KZ7-A nrPDB Length = 346 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 113/215 (52%), Gaps = 11/215 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR L+ +G G + V A TG +VA+K + + + ++ +RE+R++K + H N+ Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 94 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L +V ++TL YLVM + G L+ H ++ E + Q++ ++Y Sbjct: 95 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILNWMR 202 H I+HRDLK NL ++ D +KI DFG + + +++ + + Y APE+ Sbjct: 149 HQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKY 208 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 VD+WS+G I+ +++G F G + L +L+E Sbjct: 209 DGPEVDVWSLGVILYTLVSGSLPFDGQN-LKELRE 242 >2QNJ-A nrPDB Length = 328 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 112/215 (52%), Gaps = 11/215 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR L+ +G G + V A TG +VAIK + + + ++ +RE+R++K + H N+ Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 73 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L +V ++TL YL+M + G L+ H ++ E + Q++ ++Y Sbjct: 74 VKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 127 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWMR 202 H I+HRDLK NL ++ D +KI DFG + + ++ + + Y APE+ Sbjct: 128 HQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKY 187 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 VD+WS+G I+ +++G F G + L +L+E Sbjct: 188 DGPEVDVWSLGVILYTLVSGSLPFDGQN-LKELRE 221 >4JG6-A nrPDB Length = 355 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 91/311 (29%), Positives = 144/311 (46%), Gaps = 53/311 (17%) Query: 14 QEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-AY 72 Q++ + + + Y + +G G+Y + T + A+K + + +KR Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK-------SKRDPT 76 Query: 73 RELR-LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDR 129 E+ LL++ +H N+I L DV+ DD Y+V M G L K+++ + E Sbjct: 77 EEIEILLRYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKILRQKFFSERE 130 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGN-LAVNEDCE---LKILDFGLARQADSEMTGY 185 +++ + K + Y+HA G++HRDLKP N L V+E ++I DFG A+Q +E G Sbjct: 131 ASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAE-NGL 189 Query: 186 VVTRWYR----APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF-KGSDHLDQLKEIMK 240 ++T Y APEV L Y DIWS+G ++ M+TG T F G D Sbjct: 190 LMTPCYTANFVAPEV-LERQGYDAACDIWSLGVLLYTMLTGYTPFANGPD---------- 238 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 P E + R+ S K + G + S A +L+ KML +D QR+ Sbjct: 239 ---DTPEEILARIGS--GKFSLSG----------GYWNSVSDTAKDLVSKMLHVDPHQRL 283 Query: 301 TAGEALAHPYF 311 TA L HP+ Sbjct: 284 TAALVLRHPWI 294 >2OU7-A nrPDB Length = 335 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 88/292 (30%), Positives = 134/292 (45%), Gaps = 54/292 (18%) Query: 33 VGSGAYGAVCSAVDGRT-----GAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G G + D T G V L +P Q E + E+ + + + H++V+ Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE----KMSMEISIHRSLAHQHVV 104 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQMLKGLRYI 144 G F + DF V+ + L H++ L E ++ + Q++ G +Y+ Sbjct: 105 GFHGFF-------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYL 157 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVV-TRWYRAPEVILNWM 201 H +IHRDLK GNL +NED E+KI DFGLA + D E + T Y APEV L+ Sbjct: 158 HRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEV-LSKK 216 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 ++ VD+WS+GCIM ++ GK F+ S LKE Y Sbjct: 217 GHSFEVDVWSIGCIMYTLLVGKPPFETS----CLKE----------------------TY 250 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 ++ KK+ SI + +P+A +L++KML D R T E L +F S Sbjct: 251 LR-----IKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 297 >2Z7Q-A nrPDB Length = 321 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 78/256 (30%), Positives = 131/256 (51%), Gaps = 44/256 (17%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA----KRAYRELR--------- 76 L+ +G G++G V ++K+ RP L+A K+A ++R Sbjct: 33 LKVLGQGSFGKV-----------FLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMER 81 Query: 77 -LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFL 133 +L + H V+ L F + L YL++ F+ G DL +L K E+ ++F Sbjct: 82 DILADVNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFY 135 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVV--TRW 190 + ++ GL ++H+ GII+RDLKP N+ ++E+ +K+ DFGL+++A D E Y T Sbjct: 136 LAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVE 195 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT-GTPPAEF 249 Y APEV+ N ++ + D WS G +M EM+TG F+G D + + I+K G P Sbjct: 196 YMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP---- 250 Query: 250 VQRLQSDEAKNYMKGL 265 + S EA++ ++ L Sbjct: 251 --QFLSTEAQSLLRAL 264 >4WNO-A nrPDB Length = 287 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 116/244 (47%), Gaps = 34/244 (13%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P R G T+T + +DL +G GA+ V GR A ++ + + Sbjct: 7 PGRGG------TETVGKFEFSRKDL--IGHGAFAVV---FKGRHRAAHDLEVAVKCINKK 55 Query: 66 LFAKRAY---RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LM 120 AK +E+++LK ++HEN++ L D ++ YLVM + G DL L Sbjct: 56 NLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSV------YLVMEYCNGGDLADYLH 109 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---------EDCELKILD 171 L ED I+ + Q+ +R +H+ GIIHRDLKP N+ ++ +KI D Sbjct: 110 AMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIAD 169 Query: 172 FGLARQADSEMTGYVV--TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 FG AR S M + + Y APEVI++ Y D+WS+G I+ + +TGK F+ S Sbjct: 170 FGFARYLQSNMMAATLCGSPMYMAPEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQAS 228 Query: 230 DHLD 233 D Sbjct: 229 SPQD 232 >4J52-A nrPDB Length = 293 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 88/292 (30%), Positives = 134/292 (45%), Gaps = 54/292 (18%) Query: 33 VGSGAYGAVCSAVDGRT-----GAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G G + D T G V L +P Q E + E+ + + + H++V+ Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQRE----KMSMEISIHRSLAHQHVV 77 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQMLKGLRYI 144 G F + DF V+ + L H++ L E ++ + Q++ G +Y+ Sbjct: 78 GFHGFFEDN-------DFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYL 130 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVV-TRWYRAPEVILNWM 201 H +IHRDLK GNL +NED E+KI DFGLA + D E + T Y APEV L+ Sbjct: 131 HRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEV-LSKK 189 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 ++ VD+WS+GCIM ++ GK F+ S LKE Y Sbjct: 190 GHSFEVDVWSIGCIMYTLLVGKPPFETS----CLKE----------------------TY 223 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 ++ KK+ SI + +P+A +L++KML D R T E L +F S Sbjct: 224 LR-----IKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >4B6L-A nrPDB Length = 281 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 112/230 (48%), Gaps = 27/230 (11%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G G + A D TG+ A+K ++ +P Q E + E+ L + ++H +++ Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQRE----KILNEIELHRDLQHRHIV 72 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMK-HEKLGEDRIQFLVYQMLKGLRYIH 145 F +D + Y+ + L + K L E +++ + Q+L GL+Y+H Sbjct: 73 RFSHHF------EDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLH 126 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLA------RQADSEMTGYVVTRWYRAPEVILN 199 GI+HRDLK GN + E+ ELK+ DFGLA Q + G T Y APEV+L Sbjct: 127 QRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICG---TPNYVAPEVLLR 183 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 + D+WS+GC+M ++ G F+ +D + + I +V T PA Sbjct: 184 -QGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL 232 >2GCD-A nrPDB Length = 309 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 70/203 (34%), Positives = 110/203 (54%), Gaps = 12/203 (5%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHE 84 ++ DL+ +G G++GAV A D R VAIKK+ Y QS + +E+R L+ +RH Sbjct: 16 LFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHP 75 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLR 142 N I + + T +LVM + +G+ L H+K L E I + + L+GL Sbjct: 76 NTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLA 129 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVIL--NW 200 Y+H+ +IHRD+K GN+ ++E +K+ DFG A + +V T ++ APEVIL + Sbjct: 130 YLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSA-SIMAPANSFVGTPYWMAPEVILAMDE 188 Query: 201 MRYTQTVDIWSVGCIMAEMITGK 223 +Y VD+WS+G E+ K Sbjct: 189 GQYDGKVDVWSLGITCIELAERK 211 >6C9D-A nrPDB Length = 459 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 112/215 (52%), Gaps = 11/215 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR + +G G + V A TG +VA+K + + + ++ +RE+R++K + H N+ Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 82 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L +V ++TL YLVM + G L+ H ++ E + Q++ ++Y Sbjct: 83 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 136 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWMR 202 H I+HRDLK NL ++ D +KI DFG + + +++ + + Y APE+ Sbjct: 137 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKY 196 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 VD+WS+G I+ +++G F G + L +L+E Sbjct: 197 DGPEVDVWSLGVILYTLVSGSLPFDGQN-LKELRE 230 >3Q53-A nrPDB Length = 306 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 73/290 (25%), Positives = 137/290 (47%), Gaps = 41/290 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y + +G GA G V +A+D TG +VAI+++ Q + + E+ +++ ++ N+ Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVMRENKNPNI 80 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 + LD + + L ++VM ++ G L ++ + E +I + + L+ L ++H Sbjct: 81 VNYLDSYLVGDEL------WVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLH 134 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNWMR 202 + +IHRD+K N+ + D +K+ DFG Q S+ + V T ++ APEV+ Sbjct: 135 SNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR-KA 193 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 Y VDIWS+G + EMI G+ + + L L ++ GTP + ++L Sbjct: 194 YGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALY-LIATNGTPELQNPEKL--------- 243 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S + + L + L +D E+R +A E + H + + Sbjct: 244 ------------------SAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >1U5R-A nrPDB Length = 348 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 69/199 (34%), Positives = 109/199 (54%), Gaps = 12/199 (6%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHE 84 ++ DL+ +G G++GAV A D R VAIKK+ Y QS + +E+R L+ +RH Sbjct: 55 LFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHP 114 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLR 142 N I + + T +LVM + +G+ L H+K L E I + + L+GL Sbjct: 115 NTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLA 168 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVIL--NW 200 Y+H+ +IHRD+K GN+ ++E +K+ DFG A + +V T ++ APEVIL + Sbjct: 169 YLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSA-SIMAPANSFVGTPYWMAPEVILAMDE 227 Query: 201 MRYTQTVDIWSVGCIMAEM 219 +Y VD+WS+G E+ Sbjct: 228 GQYDGKVDVWSLGITCIEL 246 >3F3Z-A nrPDB Length = 277 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 86/301 (28%), Positives = 140/301 (46%), Gaps = 44/301 (14%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 T ++ Y +G G++G V AV T + A KK+ + F ++ R +E+ ++ Sbjct: 3 TKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDV--DRFKQEIEIM 60 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKL-GEDRIQFLVYQ 136 K + H N+I L ET +D TD YLVM G +L + + H+++ E ++ Sbjct: 61 KSLDHPNIIRLY------ETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKD 114 Query: 137 MLKGLRYIHAAGIIHRDLKPGN---LAVNEDCELKILDFGLAR--QADSEMTGYVVTRWY 191 +L + Y H + HRDLKP N L + D LK++DFGLA + M V T +Y Sbjct: 115 VLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYY 174 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 +P+V+ Y D WS G +M ++ G F + + +I + T T P Sbjct: 175 VSPQVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFP----- 227 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +KD+ N SP A +L+ ++L +QR+T+ +AL H +F Sbjct: 228 ------------------EKDW----LNVSPQAESLIRRLLTKSPKQRITSLQALEHEWF 265 Query: 312 E 312 E Sbjct: 266 E 266 >2HAK-A nrPDB Length = 328 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 112/215 (52%), Gaps = 11/215 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR + +G G + V A TG +VA+K + + + ++ +RE+R++K + H N+ Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 76 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L +V ++TL YLVM + G L+ H ++ E + Q++ ++Y Sbjct: 77 VKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 130 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWMR 202 H I+HRDLK NL ++ D +KI DFG + + +++ + + Y APE+ Sbjct: 131 HQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKY 190 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 VD+WS+G I+ +++G F G + L +L+E Sbjct: 191 DGPEVDVWSLGVILYTLVSGSLPFDGQN-LKELRE 224 >5YKS-A nrPDB Length = 377 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 80/277 (28%), Positives = 132/277 (47%), Gaps = 21/277 (7%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P +GF R K A +Y + +G G + V A TG KVA+K + + Sbjct: 20 PHMAGFKRGYDGKIA----GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT 75 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHE 123 L ++E+R +K ++H N++ L +V +D T YL++ G +MKHE Sbjct: 76 LATGHLFQEVRCMKLVQHPNIVRLYEV------IDTQTKLYLILELGDGGDMFDYIMKHE 129 Query: 124 K-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL-KILDFGLAR--QAD 179 + L ED + Q++ + Y H ++HRDLKP N+ E L K+ DFG + Q Sbjct: 130 EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG 189 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 ++T + Y APE++L VDIWS+G I+ ++ G+ F+ ++ + L IM Sbjct: 190 KKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 249 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASI 276 T P+ S E K+ + + + + K AS+ Sbjct: 250 DCKYTVPSHV-----SKECKDLITRMLQRDPKRRASL 281 >1ZWS-A nrPDB Length = 288 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 131/292 (44%), Gaps = 46/292 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTG----AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +GSG + V + TG AK K+ R + + + RE+ +L+ + H NV Sbjct: 18 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNV 77 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 I L DV+ ++ TD L++ + G L + E L E+ + Q+L G+ Y+ Sbjct: 78 ITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 145 HAAGIIHRDLKPGNLAVNEDC----ELKILDFGLARQADS--EMTGYVVTRWYRAPEVIL 198 H I H DLKP N+ + + +K++DFGLA + + E T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV- 190 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 N+ D+WS+G I +++G + F G + L I V+ EF Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEF--------- 241 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 ++ S LA + + K+LV + +R+T EAL HP+ Sbjct: 242 ------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >4YZB-A nrPDB Length = 491 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 91/330 (27%), Positives = 156/330 (47%), Gaps = 46/330 (13%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-R 60 S A G + Q T A+ R Y+ + +G G++G V D TG + A+K + R Sbjct: 10 SDKLAATPGMFVQHST-AAFSDR--YKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKR 66 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GK 118 + + + +E+ LLK + H N++ L + F +D FYLV + G +L + Sbjct: 67 QVKQKTDKELLLKEVELLKKLDHPNIMKLYEFF------EDKGYFYLVTEVYTGGELFDE 120 Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLA 175 ++ ++ E ++ Q+L G+ Y+H I+HRDLKP NL + +D ++I+DFGL+ Sbjct: 121 IISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLS 180 Query: 176 RQADS--EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 +S +M + T +Y APEV+ Y + D+WS G I+ +++G F G++ D Sbjct: 181 THFESTKKMKDKIGTAYYIAPEVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFD 238 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 LK++ E + LP+ +K S A +L+ KML Sbjct: 239 ILKKV------------------EKGKFTFDLPQWKK---------VSEPAKDLIRKMLA 271 Query: 294 LDAEQRVTAGEALAHPYFESLHDTEDEPQV 323 R++A +AL H + ++ D V Sbjct: 272 YVPTMRISARDALEHEWLKTTDAATDSIDV 301 >5JZN-A nrPDB Length = 280 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 90/310 (29%), Positives = 146/310 (47%), Gaps = 49/310 (15%) Query: 14 QEVTKTAWEVRAV----YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 +EV++ +++ A Y+ + +G G + V V+ T + A+K + + S+ K Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKK---SKCRGK 60 Query: 70 R--AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKL 125 E+ +L+ ++H N++ L+ E +D T+ YLVM + G DL + K Sbjct: 61 EHMIQNEVSILRRVKHPNIVLLI------EEMDVPTELYLVMELVKGGDLFDAITSTNKY 114 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE----LKILDFGLARQADSE 181 E ++Y + ++Y+H+ I+HRD+KP NL V E + LK+ DFGLA D Sbjct: 115 TERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP 174 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 + T Y APE+I Y VDIW+ G I ++ G F+GS DQ E++ Sbjct: 175 LYTVCGTPTYVAPEIIAE-TGYGLKVDIWAAGVITYILLCGFPPFRGSGD-DQ--EVL-- 228 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFAS-ILTNASPLAVNLLEKMLVLDAEQRV 300 F Q L + + DF S N S A L+ ML++D +QR Sbjct: 229 -------FDQIL--------------MGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRF 267 Query: 301 TAGEALAHPY 310 +A + L HP+ Sbjct: 268 SAVQVLEHPW 277 >2A27-A nrPDB Length = 321 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 130/292 (44%), Gaps = 46/292 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTG----AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +GSG + V + TG AK K+ R + + + RE+ +L+ + H NV Sbjct: 18 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNV 77 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 I L DV+ ++ TD L++ + G L + E L E+ + Q+L G+ Y+ Sbjct: 78 ITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 145 HAAGIIHRDLKPGNLAVNEDC----ELKILDFGLARQADS--EMTGYVVTRWYRAPEVIL 198 H I H DLKP N+ + + +K++DFGLA + + E T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV- 190 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 N+ D+WS+G I +++G + F G + L I V+ EF Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF--------- 241 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 + S LA + + K+LV + +R+T EAL HP+ Sbjct: 242 ------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPW 275 >6CMJ-A nrPDB Length = 321 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 109/211 (51%), Gaps = 23/211 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRP---------FQSELFAKRAYRELRLLKHMRH 83 +G G+YG V A + A+K L + Q ++ Y+E+ +LK + H Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKLGEDRIQFLVYQMLKG 140 NV+ L++V LDD + +L M F + G +M+ + L ED+ +F ++KG Sbjct: 102 PNVVKLVEV------LDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKG 155 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVI 197 + Y+H IIHRD+KP NL V ED +KI DFG++ + +D+ ++ V T + APE + Sbjct: 156 IEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESL 215 Query: 198 LNWMRY--TQTVDIWSVGCIMAEMITGKTLF 226 + + +D+W++G + + G+ F Sbjct: 216 SETRKIFSGKALDVWAMGVTLYCFVFGQCPF 246 >2YAB-A nrPDB Length = 361 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 77/293 (26%), Positives = 130/293 (44%), Gaps = 46/293 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTG----AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +GSG + V + TG AK K+ R + + + RE+ +L+ + H N+ Sbjct: 18 EELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNI 77 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 I L DV+ ++ TD L++ + G L + E L E+ + Q+L G+ Y+ Sbjct: 78 ITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 145 HAAGIIHRDLKPGNLAVNEDC----ELKILDFGLARQADS--EMTGYVVTRWYRAPEVIL 198 H I H DLKP N+ + + +K++DFGLA + + E T + APE++ Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV- 190 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 N+ D+WS+G I +++G + F G + L I V+ EF Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF--------- 241 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + S LA + + K+LV + +R+T EAL HP+ Sbjct: 242 ------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 276 >3GUB-A nrPDB Length = 295 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 92/332 (27%), Positives = 149/332 (44%), Gaps = 58/332 (17%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIK--KLYRPFQSELFAK 69 +RQE V Y + +GSG + V + TG + A K K R S Sbjct: 4 FRQE------NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVS 57 Query: 70 RA--YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKL 125 R RE+ +LK ++H NVI L +V+ ++ TD L+ + G L + E L Sbjct: 58 REDIEREVSILKEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESL 111 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE----DCELKILDFGLARQAD-- 179 E+ + Q+L G+ Y+H+ I H DLKP N+ + + +KI+DFGLA + D Sbjct: 112 TEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG 171 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 +E T + APE++ N+ D+WS+G I +++G + F G + L + Sbjct: 172 NEFKNIFGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVS 230 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 V NY E E + F +N S LA + + ++LV D ++R Sbjct: 231 AV------------------NY-----EFEDEYF----SNTSALAKDFIRRLLVKDPKKR 263 Query: 300 VTAGEALAHPYF------ESLHDTEDEPQVQK 325 +T ++L HP+ ++L PQ +K Sbjct: 264 MTIQDSLQHPWIKPKDTQQALSSAWSHPQFEK 295 >3BHH-A nrPDB Length = 295 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 79/292 (27%), Positives = 131/292 (44%), Gaps = 42/292 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y+ + +G GA+ V V TG + A K + S ++ RE R+ + ++H N+ Sbjct: 6 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 65 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L D ++ + YLV + G ++ E E + Q+L+ + + Sbjct: 66 VRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 119 Query: 145 HAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAPEVIL 198 H G++HRDLKP NL + C+ +K+ DFGLA + + G+ T Y +PEV L Sbjct: 120 HQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV-L 178 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y + VDIW+ G I+ ++ G F D ++I +A Sbjct: 179 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI------------------KA 220 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 Y PE + +P A NL+ +ML ++ +R+TA EAL HP+ Sbjct: 221 GAYDFPSPEWD---------TVTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >4EQM-A nrPDB Length = 294 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 107/209 (51%), Gaps = 14/209 (6%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-RPFQSELFAKRAYRELRLLKHMRHEN 85 Y+ + +G G V A D KVAIK ++ P + E KR RE+ + H+N Sbjct: 13 YKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQN 72 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRY 143 ++ ++DV D+ +YLVM ++ G L + ++ H L D Q+L G+++ Sbjct: 73 IVSMIDVDEEDDC------YYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKH 126 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR---QADSEMTGYVV-TRWYRAPEVILN 199 H I+HRD+KP N+ ++ + LKI DFG+A+ + T +V+ T Y +PE Sbjct: 127 AHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQ-AK 185 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKG 228 + DI+S+G ++ EM+ G+ F G Sbjct: 186 GEATDECTDIYSIGIVLYEMLVGEPPFNG 214 >2J90-A nrPDB Length = 304 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 137/297 (46%), Gaps = 48/297 (16%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIK--KLYRPFQSELFAKRAY--RELRLLKHMRHENV 86 + +GSG + V TG + A K K R S R RE+ +L+ +RH N+ Sbjct: 32 EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNI 91 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 I L D+F ++ TD L++ + G L + E L ED + Q+L G+ Y+ Sbjct: 92 ITLHDIF------ENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 145 HAAGIIHRDLKPGNLAVNE----DCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVIL 198 H+ I H DLKP N+ + + + +K++DFG+A +A +E T + APE++ Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIV- 204 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 N+ D+WS+G I +++G + F G + L I V Sbjct: 205 NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV----------------- 247 Query: 259 KNYMKGLPELEKKDF-ASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 NY DF +N S LA + + ++LV D ++R+T ++L H + +++ Sbjct: 248 -NY----------DFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAI 293 >5D9K-A nrPDB Length = 330 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 69/225 (30%), Positives = 119/225 (52%), Gaps = 16/225 (7%) Query: 30 LQPVGSGAYGAV--CSAVDGRTGAKVAIKKLYRPFQSELFAK-RAYRELRLLKHMRHENV 86 L+ +G G++G V + G ++ K+ + ++ + R E +L + H + Sbjct: 35 LKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFI 94 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L F + L YL++ F+ G DL +L K E+ ++F + ++ L ++ Sbjct: 95 VKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVV--TRWYRAPEVILNWM 201 H+ GII+RDLKP N+ ++E+ +K+ DFGL++++ D E Y T Y APEV+ N Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRR 207 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT-GTP 245 +TQ+ D WS G +M EM+TG F+G D + + I+K G P Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >3MN3-A nrPDB Length = 271 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 135/291 (46%), Gaps = 43/291 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL-FAKRAYRELRLLKHMRHEN 85 Y+ ++ +G G++G V A TG KVA+K + + ++ R RE+ L+ +RH + Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 65 Query: 86 VIGLLDVF-TPDETLDDFTDFYLVMPFMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRY 143 +I L DV + DE + +V+ + G +L +++ +K+ E + Q++ + Y Sbjct: 66 IIKLYDVIKSKDEII-------MVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWM 201 H I+HRDLKP NL ++E +KI DFGL+ D + + Y APEVI + Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 VD+WS G I+ M+ + F + P F KN Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPFDDE--------------SIPVLF---------KNI 215 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 G+ L K SP A L+++ML+++ R++ E + +F+ Sbjct: 216 SNGVYTLPK--------FLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >5IG1-A nrPDB Length = 344 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/286 (27%), Positives = 130/286 (45%), Gaps = 41/286 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA+ V V+ RTG A+K + + RE+ + ++HE+++ + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 93 FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGII 150 F D + FYLV ++ G +++ + E ++Q+L L++ H+ II Sbjct: 85 FR------DESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNII 138 Query: 151 HRDLKPGNLAV---NEDCELKILDFGLARQADSEMT--GYVVTRWYRAPEVILNWMRYTQ 205 HRDLKP NL + + + +KI DFGLA + T G+ T Y +PEVI + Y Sbjct: 139 HRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRR-VPYDT 197 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 VD+W+ G I+ ++ G F DH Q+L + + KN Sbjct: 198 AVDVWACGVILYILLVGYPPFWEEDH-------------------QKLYA-QIKNCQYDF 237 Query: 266 PELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 P E + S+ T A L++ ML + ++R T E L HP+ Sbjct: 238 PSPE---WDSVTTAAK----ELIKAMLEPNPKRRPTVQELLQHPWI 276 >4APC-A nrPDB Length = 350 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 116/227 (51%), Gaps = 16/227 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y LQ +G G++G G + IK++ S + + RE+ +L +M+H N+ Sbjct: 26 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 85 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK---LGEDRIQFLVYQMLKGLR 142 + + F + +L Y+VM + G DL K + +K ED+I Q+ L+ Sbjct: 86 VQYRESFEENGSL------YIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK 139 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVILN 199 ++H I+HRD+K N+ + +D +++ DFG+AR +S + + T +Y +PE+ N Sbjct: 140 HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICEN 199 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 Y DIW++GC++ E+ T K F+ + + +I ++G+ P Sbjct: 200 -KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKI--ISGSFP 243 >2JC6-A nrPDB Length = 334 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/303 (26%), Positives = 142/303 (46%), Gaps = 46/303 (15%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--REL 75 K A +++ ++ + +G+GA+ V A + TG A+K + + L K + E+ Sbjct: 15 KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPK---KALKGKESSIENEI 71 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFL 133 +L+ ++HEN++ L D++ L YLVM + G ++++ E L Sbjct: 72 AVLRKIKHENIVALEDIYESPNHL------YLVMQLVSGGELFDRIVEKGFYTEKDASTL 125 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNL---AVNEDCELKILDFGLARQADSE--MTGYVVT 188 + Q+L + Y+H GI+HRDLKP NL + +E+ ++ I DFGL++ M+ T Sbjct: 126 IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGT 185 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 Y APEV+ Y++ VD WS+G I ++ G F + ++I+K + Sbjct: 186 PGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSP 244 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 + + SD AK++++ NL+EK D +R T +A H Sbjct: 245 YWDDI-SDSAKDFIR----------------------NLMEK----DPNKRYTCEQAARH 277 Query: 309 PYF 311 P+ Sbjct: 278 PWI 280 >4OW8-A nrPDB Length = 283 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 107/213 (50%), Gaps = 9/213 (4%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL-FAKRAYRELRLLKHMRHEN 85 YR + + +G G V AVD R G +VA+K L F S+ F +R E R + H Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 72 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRY 143 + + D + + + YLVM + G L ++K +L ++ Q + L+ Sbjct: 73 IASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 131 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVV-TRWYRAPEVILN 199 HAAG++HRD+KPGN+ + ++KI DFG+A+ D+ TG V+ T Y APE L Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 + D++S+G + E ++GK F G L Sbjct: 192 H-DASPASDVYSLGVVGYEAVSGKRPFAGDGAL 223 >5EZV-A nrPDB Length = 560 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/200 (34%), Positives = 100/200 (50%), Gaps = 13/200 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G +G V TG KVA+K L R +S + RE++ LK RH ++I L Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 V TP TDF++VM ++ G + KH ++ E + L Q+L + Y H Sbjct: 96 VISTP-------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 148 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 149 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 208 Query: 207 VDIWSVGCIMAEMITGKTLF 226 VDIWS G I+ ++ G F Sbjct: 209 VDIWSCGVILYALLCGTLPF 228 >4CFF-A nrPDB Length = 571 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/200 (34%), Positives = 100/200 (50%), Gaps = 13/200 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G +G V TG KVA+K L R +S + RE++ LK RH ++I L Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 V TP TDF++VM ++ G + KH ++ E + L Q+L + Y H Sbjct: 101 VISTP-------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 153 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 154 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 213 Query: 207 VDIWSVGCIMAEMITGKTLF 226 VDIWS G I+ ++ G F Sbjct: 214 VDIWSCGVILYALLCGTLPF 233 >4KIK-B nrPDB Length = 677 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 72/216 (33%), Positives = 109/216 (50%), Gaps = 18/216 (8%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 T AWE++ + +G+G +G V + TG ++AIK+ + S +R E++ Sbjct: 17 TCGAWEMK------ERLGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQ 69 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----LGEDRIQ 131 +++ + H NV+ DV + L L M + G DL K + + L E I Sbjct: 70 IMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAIL 129 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL---KILDFGLARQAD--SEMTGYV 186 L+ + LRY+H IIHRDLKP N+ + + + KI+D G A++ D S T +V Sbjct: 130 TLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFV 189 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 T Y APE +L +YT TVD WS G + E ITG Sbjct: 190 GTLQYLAPE-LLEQQKYTVTVDYWSFGTLAFECITG 224 >4CQG-A nrPDB Length = 331 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 74/296 (25%), Positives = 132/296 (44%), Gaps = 46/296 (15%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKH 80 E+ Y + +G+G + V A TG VAIK + + S+L R E+ LK Sbjct: 6 ELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDL--PRVKTEIDALKS 63 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQML 138 +RH+++ L V L+ ++V+ + G ++ ++L E+ + + Q+L Sbjct: 64 LRHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIL 117 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ----ADSEMTGYVVTRWYRAP 194 + Y+H+ G HRDLKP NL +E+ +LK++DFGL + D + + Y AP Sbjct: 118 SAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAP 177 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 E+I D+WS+G ++ ++ G F + + K+IM+ P Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWL----- 232 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 SP ++ LL++ML +D ++R++ L HP+ Sbjct: 233 --------------------------SPSSILLLQQMLQVDPKKRISMRNLLNHPW 262 >4X3F-A nrPDB Length = 337 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 107/213 (50%), Gaps = 9/213 (4%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL-FAKRAYRELRLLKHMRHEN 85 YR + + +G G V AVD R G +VA+K L F S+ F +R E R + H Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 73 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRY 143 + + D + + + YLVM + G L ++K +L ++ Q + L+ Sbjct: 74 IASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 132 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVV-TRWYRAPEVILN 199 HAAG++HRD+KPGN+ + ++KI DFG+A+ D+ TG V+ T Y APE L Sbjct: 133 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 192 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 + D++S+G + E ++GK F G L Sbjct: 193 H-DASPASDVYSLGVVGYEAVSGKRPFAGDGAL 224 >4L42-A nrPDB Length = 346 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 92/332 (27%), Positives = 152/332 (45%), Gaps = 52/332 (15%) Query: 30 LQPVGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYR--ELRLLKHMRHE 84 L+ +G G YG V TG A+K L + A+ E +L+ ++H Sbjct: 23 LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHP 82 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLG---EDRIQFLVYQMLKG 140 ++ L+ F L YL++ ++ G +L M+ E+ G ED F + ++ Sbjct: 83 FIVDLIYAFQTGGKL------YLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEISMA 134 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVI 197 L ++H GII+RDLKP N+ +N +K+ DFGL +++ + T + T Y APE++ Sbjct: 135 LGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEIL 194 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 + + + VD WS+G +M +M+TG F G + + +I+K P Q E Sbjct: 195 MR-SGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ-----E 248 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF-----E 312 A++ +K +L K++ AS L A P AGE AHP+F E Sbjct: 249 ARDLLK---KLLKRNAASRL-GAGP-----------------GDAGEVQAHPFFRHINWE 287 Query: 313 SLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVT 344 L + EP + S +DV + ++ R T Sbjct: 288 ELLARKVEPPFKPLLQSEEDVSQFDSKFTRQT 319 >2V7O-A nrPDB Length = 336 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/292 (26%), Positives = 130/292 (44%), Gaps = 42/292 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y+ + +G GA+ V V + A K + S ++ RE R+ + ++H N+ Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 92 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L D ++ + YLV + G ++ E E ++Q+L+ + +I Sbjct: 93 VRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 146 Query: 145 HAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAPEVIL 198 H I+HRDLKP NL + C+ +K+ DFGLA + E G+ T Y +PEV L Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV-L 205 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y + VDIW+ G I+ ++ G F D ++I +A Sbjct: 206 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI------------------KA 247 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 Y PE + +P A NL+ +ML ++ +R+TA +AL HP+ Sbjct: 248 GAYDFPSPEWD---------TVTPEAKNLINQMLTINPAKRITADQALKHPW 290 >3KN6-A nrPDB Length = 325 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 69/281 (24%), Positives = 133/281 (47%), Gaps = 45/281 (16%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +P+G G++ V ++ A+K + + ++ ++ L+L + H N++ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN--TQKEITALKLCE--GHPNIVKLH 72 Query: 91 DVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 +VF D +LVM + G ++ K + E +++ +++ + ++H G Sbjct: 73 EVF------HDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVG 126 Query: 149 IIHRDLKPGNLAV---NEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNWMR 202 ++HRDLKP NL N++ E+KI+DFG AR + + T Y APE +LN Sbjct: 127 VVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNG 185 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 Y ++ D+WS+G I+ M++G+ F+ D +T T E +++++ Sbjct: 186 YDESCDLWSLGVILYTMLSGQVPFQSHDR--------SLTCTSAVEIMKKIK-------- 229 Query: 263 KGLPELEKKDFA---SILTNASPLAVNLLEKMLVLDAEQRV 300 K DF+ N S A +L++ +L +D +R+ Sbjct: 230 -------KGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRL 263 >5FG8-A nrPDB Length = 285 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 128/290 (44%), Gaps = 44/290 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G GA+ V V TG + A K + + ++ RE R+ + + H N++ L Sbjct: 20 EELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLH 79 Query: 91 DVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 D ++ + YLV + G ++ E E + Q+L+ + + H G Sbjct: 80 D------SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 133 Query: 149 IIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAPEVILNWMR 202 ++HRDLKP NL + + +K+ DFGLA + + G+ T Y +PEV L Sbjct: 134 VVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV-LKKEP 192 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD-EAKNY 261 Y ++VDIW+ G I+ ++ G F D RL S +A Y Sbjct: 193 YGKSVDIWACGVILYILLVGYPPFWDEDQ-------------------HRLYSQIKAGAY 233 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 PE + +P A NL+ +ML ++ +R+TA EAL HP+ Sbjct: 234 DYPSPEWD---------TVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >4CFH-A nrPDB Length = 493 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 85/289 (29%), Positives = 128/289 (44%), Gaps = 50/289 (17%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G +G V TG KVA+K L R +S + RE++ LK RH ++I L Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 V TP +D ++VM ++ G + K+ +L E + L Q+L G+ Y H Sbjct: 101 VISTP-------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 153 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 154 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 213 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VDIWS G I+ ++ G TL DH +P Sbjct: 214 VDIWSSGVILYALLCG-TLPFDDDH---------------------------------VP 239 Query: 267 ELEKKDFASILTNA---SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 L KK I +P ++LL+ ML +D +R T + H +F+ Sbjct: 240 TLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK 288 >6B2Q-A nrPDB Length = 317 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 107/213 (50%), Gaps = 9/213 (4%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL-FAKRAYRELRLLKHMRHEN 85 YR + + +G G V AVD R G +VA+K L F S+ F +R E R + H Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPG 93 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRY 143 + + D + + + YLVM + G L ++K +L ++ Q + L+ Sbjct: 94 IASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQI 152 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVV-TRWYRAPEVILN 199 HAAG++HRD+KPGN+ + ++KI DFG+A+ D+ TG V+ T Y APE L Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 + D++S+G + E ++GK F G L Sbjct: 213 H-DASPASDVYSLGVVGYEAVSGKRPFAGDGAL 244 >1PHK-A nrPDB Length = 298 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 53/309 (17%) Query: 24 RAVYRDLQP---VGSGAYGAVCSAVDGRTGAKVAIKKL-------YRPFQSELFAKRAYR 73 Y + +P +G G V + T + A+K + + + + + + Sbjct: 13 HGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLK 72 Query: 74 ELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRI 130 E+ +L+ + H N+I L D + + T F+LV M G L + L E Sbjct: 73 EVDILRKVSGHPNIIQLKDTYETN------TFFFLVFDLMKKGELFDYLTEKVTLSEKET 126 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD--SEMTGYVVT 188 + ++ +L+ + +H I+HRDLKP N+ +++D +K+ DFG + Q D ++ T Sbjct: 127 RKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGT 186 Query: 189 RWYRAPEVILNWMR-----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 Y APE+I M Y + VD+WS G IM ++ G F + L+ IM Sbjct: 187 PSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM---- 242 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 + NY G PE + + S +L+ + LV+ ++R TA Sbjct: 243 --------------SGNYQFGSPEWD---------DYSDTVKDLVSRFLVVQPQKRYTAE 279 Query: 304 EALAHPYFE 312 EALAHP+F+ Sbjct: 280 EALAHPFFQ 288 >3NYO-A nrPDB Length = 576 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 89/315 (28%), Positives = 140/315 (44%), Gaps = 52/315 (16%) Query: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-A 71 RQ VTK +R + +G G +G VC+ TG A KKL + + + A Sbjct: 178 RQPVTKN------TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGE 127 E ++L+ + V+ L + ET D LV+ M G DL + H E Sbjct: 232 LNEKQILEKVNSRFVVSLAYAY---ETKDALC---LVLTLMNGGDLKFHIYHMGQAGFPE 285 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT--GY 185 R F ++ GL +H I++RDLKP N+ +++ ++I D GLA T G Sbjct: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR 345 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 V T Y APEV+ N RYT + D W++GC++ EMI G++ F+ + +E+ ++ Sbjct: 346 VGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV----- 300 P E+ +R SP A +L ++L D +R+ Sbjct: 405 PEEYSERF---------------------------SPQARSLCSQLLCKDPAERLGCRGG 437 Query: 301 TAGEALAHPYFESLH 315 +A E HP F+ L+ Sbjct: 438 SAREVKEHPLFKKLN 452 >4REW-A nrPDB Length = 540 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 71/209 (33%), Positives = 105/209 (50%), Gaps = 14/209 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G +G V TG KVA+K L R +S + RE++ LK RH ++I L Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 V TP +D ++VM ++ G + K+ +L E + L Q+L G+ Y H Sbjct: 74 VISTP-------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 126 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 127 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 186 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 VDIWS G I+ ++ G TL DH+ L Sbjct: 187 VDIWSSGVILYALLCG-TLPFDDDHVPTL 214 >1KOB-A nrPDB Length = 387 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 139/298 (46%), Gaps = 43/298 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y L+ +GSGA+G V V+ TG K + P+ + + + E+ ++ + H + Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK--NEISIMNQLHHPKL 110 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQFLVYQMLKGLRY 143 I L D F +D + L++ F+ G +L + E K+ E + + Q +GL++ Sbjct: 111 INLHDAF------EDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKH 164 Query: 144 IHAAGIIHRDLKPGNLAV--NEDCELKILDFGLARQADSEMTGYVVTRW--YRAPEVILN 199 +H I+H D+KP N+ + +KI+DFGLA + + + V T + APE++ + Sbjct: 165 MHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIV-D 223 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 D+W++G + +++G + F G D L+ L+ + + Sbjct: 224 REPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDW---------------- 267 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 E ++ F+S+ SP A + ++ +L + +R+T +AL HP+ + H Sbjct: 268 -------EFDEDAFSSV----SPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSN 314 >2X4F-A nrPDB Length = 373 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 86/316 (27%), Positives = 143/316 (45%), Gaps = 47/316 (14%) Query: 5 PPARSGFYRQEVTKTAWEVRAVY--RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 PPA F + VT V + Y + +G G +G V + TG K+A K + Sbjct: 69 PPA--PFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRG 126 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK 121 + + E+ ++ + H N+I L D F D LVM ++ G +L + Sbjct: 127 MKD--KEEVKNEISVMNQLDHANLIQLYDAFESK------NDIVLVMEYVDGGELFDRII 178 Query: 122 HEKLGEDRIQFLVY--QMLKGLRYIHAAGIIHRDLKPGN-LAVNEDC-ELKILDFGLAR- 176 E + +++ Q+ +G+R++H I+H DLKP N L VN D ++KI+DFGLAR Sbjct: 179 DESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARR 238 Query: 177 -QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 + ++ T + APEV+ N+ + D+WSVG I +++G + F G + + L Sbjct: 239 YKPREKLKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETL 297 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 I+ +LE ++F I S A + K+L+ + Sbjct: 298 NNILACRW-----------------------DLEDEEFQDI----SEEAKEFISKLLIKE 330 Query: 296 AEQRVTAGEALAHPYF 311 R++A EAL HP+ Sbjct: 331 KSWRISASEALKHPWL 346 >4YNZ-A nrPDB Length = 342 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 70/218 (32%), Positives = 106/218 (48%), Gaps = 11/218 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR + +G G G V + T KVAIK + R SE + RE+ +LK + H +V Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L DV+ + L YLV+ + G L+K +L + Q++ L + Sbjct: 72 LKLHDVYENKKYL------YLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLA--RQADSEMTGYVVTRWYRAPEVILNWMR 202 H+ I HRDLKP NL ++E ++I DFG+A + DS + + Y PEVI Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 + D+WS G I+ ++ G F D+L QL E +K Sbjct: 186 DGRKADVWSCGVILFALLVGALPFD-DDNLRQLLEKVK 222 >4B8L-A nrPDB Length = 286 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 17/218 (7%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRHENVIGL 89 +P+G G +G V A + + +A+K L++ + E + RE+ + H+RH N++ + Sbjct: 21 RPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRM 80 Query: 90 LDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 + F D YL++ F G +L KH + E R + ++ L Y H Sbjct: 81 YNYF------HDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHER 134 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWYRAPEVILNWMRY 203 +IHRD+KP NL + ELKI DFG + A S M G T Y PE+I + Sbjct: 135 KVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCG---TLDYLPPEMI-EGKTH 190 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 + VD+W G + E + G F H + + I+ V Sbjct: 191 DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV 228 >2VZ6-A nrPDB Length = 313 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 133/297 (44%), Gaps = 44/297 (14%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 +++Y+ + +G GA+ V V G + A K + S ++ RE R+ + ++H Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 80 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 N++ L D ++ + YL+ + G ++ E E + Q+L+ + Sbjct: 81 PNIVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAV 134 Query: 142 RYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMT---GYVVTRWYRAPE 195 + H G++HRDLKP NL + + +K+ DFGLA + + E G+ T Y +PE Sbjct: 135 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 194 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL-Q 254 V L Y + VD+W+ G I+ ++ G F D RL Q Sbjct: 195 V-LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ-------------------HRLYQ 234 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 235 QIKAGAYDFPSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 >5YV8-A nrPDB Length = 298 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 53/166 (31%), Positives = 94/166 (56%), Gaps = 14/166 (8%) Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKL 125 ++ Y+E+ +LK + H NV+ L++V LDD + +L M F + G +M+ + L Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEV------LDDPNEDHLYMVFELVNQGPVMEVPTLKPL 134 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEM 182 ED+ +F ++KG+ Y+H IIHRD+KP NL V ED +KI DFG++ + +D+ + Sbjct: 135 SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALL 194 Query: 183 TGYVVTRWYRAPEVILNWMRY--TQTVDIWSVGCIMAEMITGKTLF 226 + V T + APE + + + +D+W++G + + G+ F Sbjct: 195 SNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 240 >4I6B-A nrPDB Length = 308 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 113/229 (49%), Gaps = 23/229 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLY------RPFQSELFAKRAYRELRLLKHMRHENV 86 +G G + A C + T KV K+ +P Q E K E+ L + + H++V Sbjct: 36 LGKGGF-AKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDK----EIELHRILHHKHV 90 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHEK-LGEDRIQFLVYQMLKGLRYI 144 + F +D + Y+++ + + ++K K L E +++ + Q++ GL+Y+ Sbjct: 91 VQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYL 144 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVILNWM 201 H I+HRDLK GN +NE ELK+ DFGLA + + T Y +PEV LN Sbjct: 145 HEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEV-LNKQ 203 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + DIW++GC+M M+ G+ F+ ++ + + I + T P+ + Sbjct: 204 GHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLL 252 >6QAU-A nrPDB Length = 280 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 85/302 (28%), Positives = 139/302 (46%), Gaps = 58/302 (19%) Query: 28 RDLQPVGSGAYGAVCSAVD-GRTGAKVAIKKLYRPFQSE---LFAKRAYRELRLLKHMRH 83 RDL VG GA+ V +T +VAIK + + S+ L K E+++LK ++H Sbjct: 16 RDL--VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK----EIKILKELQH 69 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGL 141 EN++ L DV ++ +LVM + G DL ++ + L ED I+ ++Q+ + Sbjct: 70 ENIVALYDVQELPNSV------FLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAM 123 Query: 142 RYIHAAGIIHRDLKPGNLAVN---------EDCELKILDFGLARQADSEMTG--YVVTRW 190 R +H+ GIIHRDLKP N+ ++ +KI DFG AR S M + Sbjct: 124 RILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPM 183 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 Y APEVI++ Y D+WS+G ++ + + GK F+ + D Sbjct: 184 YMAPEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDL---------------- 226 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 R+ ++ ++ M +P SP NLL +L + + R+ +HP+ Sbjct: 227 -RMFYEKNRSLMPSIPR-----------ETSPYLANLLLGLLQRNQKDRMDFEAFFSHPF 274 Query: 311 FE 312 E Sbjct: 275 LE 276 >4TNB-A nrPDB Length = 590 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 90/319 (28%), Positives = 142/319 (44%), Gaps = 60/319 (18%) Query: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-- 70 RQ VTK +R + +G G +G VC+ TG A K+L + + KR Sbjct: 178 RQPVTKNT------FRQYRVLGKGGFGEVCACQVRATGKMYACKRL----EKKRIKKRKG 227 Query: 71 ---AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG---KLMKHE 123 A E ++L+ + + V+ L + ET D LV+ M G DL M + Sbjct: 228 ESMALNEKQILEKVNSQFVVNLAYAY---ETKDALC---LVLTIMNGGDLKFHIYNMGNP 281 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-- 181 E+R F ++L GL +H ++RDLKP N+ +++ ++I D GLA + Sbjct: 282 GFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDL 341 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 + G V T Y APEV LN RY + D W +GC++ EMI G++ F+G + +E+ + Sbjct: 342 IRGRVGTVGYMAPEV-LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRR 400 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV- 300 + + S+EAK+ K L L DA+QR+ Sbjct: 401 VLETEEVYSHKF-SEEAKSICKML--------------------------LTKDAKQRLG 433 Query: 301 ----TAGEALAHPYFESLH 315 A E HP+F +++ Sbjct: 434 CQEEEAAEVKRHPFFRNMN 452 >5U6Y-A nrPDB Length = 461 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 131/294 (44%), Gaps = 42/294 (14%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 +Y+ + +G GA+ V V G + A K + S ++ RE R+ + ++H N Sbjct: 1 MYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 60 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L D ++ + YL+ + G ++ E E + Q+L+ + + Sbjct: 61 IVRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 114 Query: 144 IHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVI 197 H G++HRDLKP NL + + +K+ DFGLA + + E G+ T Y +PEV Sbjct: 115 CHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV- 173 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L Y + VD+W+ G I+ ++ G F D ++I + Sbjct: 174 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------K 215 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 216 AGAYDFPSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 >3UTO-A nrPDB Length = 573 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 86/339 (25%), Positives = 147/339 (43%), Gaps = 45/339 (13%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 +Y Q V V Y + +G+GA+G V + TG A K + P +S+ R Sbjct: 143 YYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR 202 Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM--KHEKLGE 127 +E++ + +RH ++ L D F +D + ++ FM G +L + + +H K+ E Sbjct: 203 --KEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKMSE 254 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL--AVNEDCELKILDFGLARQADSEMTGY 185 D + Q+ KGL ++H +H DLKP N+ ELK++DFGL D + + Sbjct: 255 DEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVK 314 Query: 186 VVTRW--YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 V T + APEV D+WSVG + +++G + F G + + L+ Sbjct: 315 VTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRN------ 367 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 V+ + + G+ E + KDF + K+L+ D R+T Sbjct: 368 ------VKSCDWNMDDSAFSGISE-DGKDF--------------IRKLLLADPNTRMTIH 406 Query: 304 EALAHPYFESLHDTEDEPQV--QKYDDSFDDVDRTLDEW 340 +AL HP+ + + Q+ +Y D + D W Sbjct: 407 QALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAW 445 >5TQX-A nrPDB Length = 655 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/213 (34%), Positives = 105/213 (49%), Gaps = 21/213 (9%) Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80 WE+R + +G+G +G VC K+AIK R S +R E++++K Sbjct: 10 WEMR------ERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKK 62 Query: 81 MRHENVIGLLDVFTPDETLDDFTDF-YLVMPFM-GTDLGKLMKHEK----LGEDRIQFLV 134 + H NV+ DV P+E D L M + G DL KL+ + L E +I L+ Sbjct: 63 LNHANVVKACDV--PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTR 189 + G+RY+H IIHRDLKP N+ + + KI+D G A+ D T +V T Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTL 180 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 Y APE+ N YT TVD WS G ++ E I G Sbjct: 181 QYLAPELFEN-KPYTATVDYWSFGTMVFECIAG 212 >2YZA-A nrPDB Length = 276 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/200 (34%), Positives = 100/200 (50%), Gaps = 13/200 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G +G V TG KVA+K L R +S + RE++ LK RH ++I L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 V TP TDF++VM ++ G + KH ++ E + L Q+L + Y H Sbjct: 79 VISTP-------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 131 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 132 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPE 191 Query: 207 VDIWSVGCIMAEMITGKTLF 226 VDIWS G I+ ++ G F Sbjct: 192 VDIWSCGVILYALLCGTLPF 211 >1KOA-A nrPDB Length = 491 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 87/339 (25%), Positives = 146/339 (43%), Gaps = 45/339 (13%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 +Y Q V V Y + +G+GA+G V + TG A K + P +S+ R Sbjct: 37 YYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVR 96 Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM--KHEKLGE 127 +E++ + +RH ++ L D F +D + ++ FM G +L + + +H K+ E Sbjct: 97 --KEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKMSE 148 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL--AVNEDCELKILDFGLARQADSEMTGY 185 D + Q+ KGL ++H +H DLKP N+ ELK++DFGL D + + Sbjct: 149 DEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVK 208 Query: 186 VV--TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 V T + APEV D+WSVG + +++G + F G + + L+ + Sbjct: 209 VTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDW 267 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 D A G+ E + KDF + K+L+ D R+T Sbjct: 268 N---------MDDSA---FSGISE-DGKDF--------------IRKLLLADPNTRMTIH 300 Query: 304 EALAHPYFESLHDTEDEPQV--QKYDDSFDDVDRTLDEW 340 +AL HP+ + + Q+ +Y D + D W Sbjct: 301 QALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAW 339 >4RLP-A nrPDB Length = 288 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 83/302 (27%), Positives = 140/302 (46%), Gaps = 47/302 (15%) Query: 26 VYRDLQPVGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYR--ELRLLKH 80 + L+ +G G YG V TG A+K L + A+ E +L+ Sbjct: 6 CFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEE 65 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLG---EDRIQFLVYQ 136 ++H ++ L+ F L YL++ ++ G +L M+ E+ G ED F + + Sbjct: 66 VKHPFIVDLIYAFQTGGKL------YLILEYLSGGEL--FMQLEREGIFMEDTACFYLAE 117 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRA 193 + L ++H GII+RDLKP N+ +N +K+ DFGL +++ + T + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PE+++ + + VD WS+G +M +M+TG F G + + +I+K P Q Sbjct: 178 PEILMR-SGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ-- 234 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 EA++ +K +L K++ AS L A P AGE AHP+F Sbjct: 235 ---EARDLLK---KLLKRNAASRL-GAGP-----------------GDAGEVQAHPFFRH 270 Query: 314 LH 315 ++ Sbjct: 271 IN 272 >2UV2-A nrPDB Length = 325 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 130/304 (42%), Gaps = 55/304 (18%) Query: 26 VYRDLQP---------VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 V RDL P +G GA+G V A + T A K + + EL + E+ Sbjct: 29 VTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEEL--EDYMVEID 86 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG---TDLGKLMKHEKLGEDRIQFL 133 +L H N++ LLD F + L ++++ F D L L E +IQ + Sbjct: 87 ILASCDHPNIVKLLDAFYYENNL------WILIEFCAGGAVDAVMLELERPLTESQIQVV 140 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRW 190 Q L L Y+H IIHRDLK GN+ D ++K+ DFG++ + + ++ T + Sbjct: 141 CKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPY 200 Query: 191 YRAPEVILNWMR----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 + APEV++ Y D+WS+G + EM + L+ ++ ++K+ + P Sbjct: 201 WMAPEVVMCETSKDRPYDYKADVWSLGITLIEM---AEIEPPHHELNPMRVLLKIAKSEP 257 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 Q S + N+ KDF L+K L + + R T + L Sbjct: 258 PTLAQ--PSRWSSNF---------KDF--------------LKKCLEKNVDARWTTSQLL 292 Query: 307 AHPY 310 HP+ Sbjct: 293 QHPF 296 >2VN9-A nrPDB Length = 301 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 79/294 (26%), Positives = 131/294 (44%), Gaps = 44/294 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y+ + +G GA+ V + TG + A K + S ++ RE R+ + ++H N+ Sbjct: 6 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 65 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L D ++ + YLV + G ++ E E + Q+L+ + + Sbjct: 66 VRLHD------SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 119 Query: 145 HAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVIL 198 H GI+HRDLKP NL + ++ +K+ DFGLA + + G+ T Y +PEV L Sbjct: 120 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV-L 178 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL-QSDE 257 Y + VD+W+ G I+ ++ G F D RL Q + Sbjct: 179 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQ-------------------HRLYQQIK 219 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 220 AGAYDFPSPEWD---------TVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >2Y7J-A nrPDB Length = 365 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 131/296 (44%), Gaps = 49/296 (16%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKL------YRPFQSELFAKRAYRELRLLKHMR-HEN 85 +G G V V TG + A+K + P Q E + RE +L+ + H + Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 +I L+D + + +LV M G L + L E + ++ +L+ + + Sbjct: 162 IITLIDSYESSSFM------FLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSF 215 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD--SEMTGYVVTRWYRAPEVILNWM 201 +HA I+HRDLKP N+ ++++ ++++ DFG + + ++ T Y APE++ M Sbjct: 216 LHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSM 275 Query: 202 R-----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 Y + VD+W+ G I+ ++ G F + L+ IM+ Sbjct: 276 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME---------------- 319 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 Y PE + + S +L+ ++L +D E R+TA +AL HP+FE Sbjct: 320 --GQYQFSSPEWDDR---------SSTVKDLISRLLQVDPEARLTAEQALQHPFFE 364 >6CKI-A nrPDB Length = 316 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 133/301 (44%), Gaps = 38/301 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA+ V + ++ T + A+K + + Q R +RE+ +L + G +V Sbjct: 21 LGEGAHARVQTCINLITSQEYAVKIIEK--QPGHIRSRVFREVEMLYQCQ-----GHRNV 73 Query: 93 FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGII 150 E ++ FYLV M G+ L + K E +V + L ++H GI Sbjct: 74 LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIA 133 Query: 151 HRDLKPGNLAV---NEDCELKILDFGLARQ----------ADSEMTGYVVTRWYRAPEVI 197 HRDLKP N+ N+ +KI DFGL + E+ + Y APEV+ Sbjct: 134 HRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVV 193 Query: 198 LNWMR----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 + Y + D+WS+G I+ +++G F G D G E Sbjct: 194 EAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRGEACPAC 245 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Q+ ++ +G E KD+A I S A +L+ K+LV DA+QR++A + L HP+ + Sbjct: 246 QNMLFESIQEGKYEFPDKDWAHI----SCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 301 Query: 314 L 314 Sbjct: 302 C 302 >4U41-A nrPDB Length = 332 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 98/209 (46%), Gaps = 13/209 (6%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 ++ ++ VG+G YG V +TG AIK + E K L+ K+ H Sbjct: 24 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLK--KYSHHR 81 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLKG 140 N+ F +LVM F G TDL K K L ED I ++ ++L+G Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVI 197 L ++H +IHRD+K N+ + E+ E+K++DFG++ Q D + ++ T ++ APEVI Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 198 LN----WMRYTQTVDIWSVGCIMAEMITG 222 Y D+WS G EM G Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEG 230 >6HXF-B nrPDB Length = 302 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 49/309 (15%) Query: 22 EVRAVYRDLQP---------VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY 72 E V RDL P +G GA+G V A + TGA A K + + EL + Sbjct: 7 EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEEL--EDYI 64 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF 132 E+ +L H ++ LL + D L +F P D L L E +IQ Sbjct: 65 VEIEILATCDHPYIVKLLGAYYHDGKLWIMIEF---CPGGAVDAIMLELDRGLTEPQIQV 121 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTR 189 + QML+ L ++H+ IIHRDLK GN+ + + ++++ DFG++ + + ++ T Sbjct: 122 VCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTP 181 Query: 190 WYRAPEVIL-NWMR---YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 ++ APEV++ M+ Y DIWS+G + EM + L+ ++ ++K+ + Sbjct: 182 YWMAPEVVMCETMKDTPYDYKADIWSLGITLIEM---AQIEPPHHELNPMRVLLKIAKSD 238 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 P + + +E +DF I + +P E R +A + Sbjct: 239 PPTLLTPSKWS-----------VEFRDFLKIALDKNP--------------ETRPSAAQL 273 Query: 306 LAHPYFESL 314 L HP+ S+ Sbjct: 274 LEHPFVSSI 282 >3KK8-A nrPDB Length = 284 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 78/288 (27%), Positives = 132/288 (45%), Gaps = 41/288 (14%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G GA+ V V TG + A K + S ++ RE R+ + ++H N++ L Sbjct: 12 EELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLH 71 Query: 91 DVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 D ++ + + YLV + G ++ E E + Q+L+ + Y H+ G Sbjct: 72 D------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNG 125 Query: 149 IIHRDLKPGNLAVNEDCE---LKILDFGLARQA-DSEM-TGYVVTRWYRAPEVILNWMRY 203 I+HR+LKP NL + + +K+ DFGLA + DSE G+ T Y +PEV L Y Sbjct: 126 IVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPY 184 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK 263 ++ VDIW+ G I+ ++ G F D +I +A Y Sbjct: 185 SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------KAGAYDY 226 Query: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 PE + +P A +L++ ML ++ ++R+TA +AL P+ Sbjct: 227 PSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >5D7A-A nrPDB Length = 308 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 100/209 (47%), Gaps = 13/209 (6%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 ++ ++ VG+G YG V +TG AIK + E K+ L+ K+ H Sbjct: 17 GIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLK--KYSHHR 74 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLKG 140 N+ F +LVM F G TDL K K L E+ I ++ ++L+G Sbjct: 75 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 134 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVI 197 L ++H +IHRD+K N+ + E+ E+K++DFG++ Q D + ++ T ++ APEVI Sbjct: 135 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 194 Query: 198 LN----WMRYTQTVDIWSVGCIMAEMITG 222 Y D+WS+G EM G Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEMAEG 223 >3TAC-A nrPDB Length = 361 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 89/324 (27%), Positives = 152/324 (46%), Gaps = 57/324 (17%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSE--LFAKRAYRELRLLKHMR 82 VY + +G G + V ++ TG + A+K + F S L + RE + ++ Sbjct: 27 VYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK 86 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLG----EDRIQFLVYQ 136 H +++ LL+ ++ D L Y+V FM G DL +++K G E + Q Sbjct: 87 HPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQ 140 Query: 137 MLKGLRYIHAAGIIHRDLKPGN--LAVNEDCE-LKILDFGLARQ-ADSEMT--GYVVTRW 190 +L+ LRY H IIHRD+KP LA E+ +K+ FG+A Q +S + G V T Sbjct: 141 ILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPH 200 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + APEV+ Y + VD+W G I+ +++G F G+ Sbjct: 201 FMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTK-------------------- 239 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 +RL + +KG ++ + ++ I +A +L+ +ML+LD +R+T EAL HP+ Sbjct: 240 ERL----FEGIIKGKYKMNPRQWSHISESAK----DLVRRMLMLDPAERITVYEALNHPW 291 Query: 311 FE-------SLHDTEDEPQVQKYD 327 + +H E Q++K++ Sbjct: 292 LKERDRYAYKIHLPETVEQLRKFN 315 >4AF3-A nrPDB Length = 292 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 109/224 (48%), Gaps = 17/224 (7%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRHENVIGL 89 +P+G G +G V A + ++ VA+K L++ + E + RE+ + H+ H N++ L Sbjct: 29 RPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRL 88 Query: 90 LDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 + F D YL++ + G +L K E R ++ ++ L Y H Sbjct: 89 YNYFY------DRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK 142 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWYRAPEVILNWMRY 203 +IHRD+KP NL + ELKI DFG + A S M G T Y PE+I M + Sbjct: 143 KVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCG---TLDYLPPEMIEGRM-H 198 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 + VD+W +G + E++ G F+ + H + + I+KV PA Sbjct: 199 NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPA 242 >2BDW-A nrPDB Length = 362 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 78/288 (27%), Positives = 132/288 (45%), Gaps = 41/288 (14%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G GA+ V V TG + A K + S ++ RE R+ + ++H N++ L Sbjct: 35 EELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLH 94 Query: 91 DVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 D ++ + + YLV + G ++ E E + Q+L+ + Y H+ G Sbjct: 95 D------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNG 148 Query: 149 IIHRDLKPGNLAVNEDCE---LKILDFGLARQA-DSEM-TGYVVTRWYRAPEVILNWMRY 203 I+HR+LKP NL + + +K+ DFGLA + DSE G+ T Y +PEV L Y Sbjct: 149 IVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV-LKKDPY 207 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK 263 ++ VDIW+ G I+ ++ G F D +I +A Y Sbjct: 208 SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI------------------KAGAYDY 249 Query: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 PE + +P A +L++ ML ++ ++R+TA +AL P+ Sbjct: 250 PSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >4RED-A nrPDB Length = 351 Score = 87.4 bits (215), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 69/209 (33%), Positives = 103/209 (49%), Gaps = 14/209 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G +G V TG VA+K L R +S + RE++ LK RH ++I L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 92 VF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 V TP +D ++VM ++ G + K+ +L E + L Q+L G+ Y H Sbjct: 82 VISTP-------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSE-MTGYVVTRWYRAPEVILNWMRYTQT 206 ++HRDLKP N+ ++ KI DFGL+ +D E + + Y APEVI + Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPE 194 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 VDIWS G I+ ++ G F DH+ L Sbjct: 195 VDIWSSGVILYALLCGTLPFD-DDHVPTL 222 >5F9E-A nrPDB Length = 353 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 102/212 (48%), Gaps = 28/212 (13%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-------QSELFAKRAYRELRLLKHMRHEN 85 +G G++G V A +T AIK L + + + KR L H Sbjct: 27 LGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRV-----LSLAWEHPF 81 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH----EKLGEDRIQFLVYQMLKGL 141 + + F E L + VM ++ G LM H K R F +++ GL Sbjct: 82 LTHMFCTFQTKENL------FFVMEYLNG--GDLMYHIQSCHKFDLSRATFYAAEIILGL 133 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVIL 198 +++H+ GI++RDLK N+ +++D +KI DFG+ ++ D++ + T Y APE++L Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILL 193 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 +Y +VD WS G ++ EM+ G++ F G D Sbjct: 194 G-QKYNHSVDWWSFGVLLYEMLIGQSPFHGQD 224 >3QA8-A nrPDB Length = 676 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/219 (33%), Positives = 108/219 (49%), Gaps = 24/219 (10%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR--- 73 T WE++ + +G+G +G V + TG +VAIK+ + EL K R Sbjct: 12 TCGPWEMK------ERLGTGGFGYVLRWIHQDTGEQVAIKQC----RQELSPKNRERWCL 61 Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----LGED 128 E++++K + H NV+ +V + L L M + G DL K + + L E Sbjct: 62 EIQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEG 121 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL---KILDFGLARQADSE--MT 183 I+ L+ + LRY+H IIHRDLKP N+ + + KI+D G A++ D T Sbjct: 122 PIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCT 181 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 +V T Y APE +L +YT TVD WS G + E ITG Sbjct: 182 EFVGTLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITG 219 >4D2V-A nrPDB Length = 356 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 133/297 (44%), Gaps = 46/297 (15%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKH 80 E+ Y + +G+G + V A TG VAIK + + S+L R E+ LK+ Sbjct: 26 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL--PRIKTEIEALKN 83 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQML 138 +RH+++ L V L+ ++V+ + G ++ ++L E+ + + Q++ Sbjct: 84 LRHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIV 137 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ----ADSEMTGYVVTRWYRAP 194 + Y+H+ G HRDLKP NL +E +LK++DFGL + D + Y AP Sbjct: 138 SAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 E+I D+WS+G ++ ++ G + A V ++ Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCG---------------FLPFDDDTAAALVAKI- 241 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 M+G K D L SP ++ LL++ML +D ++R++ L HP+ Sbjct: 242 -------MRG-----KYDVPKWL---SPSSILLLQQMLQVDPKKRISMKNLLNHPWI 283 >5WAX-A nrPDB Length = 310 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 124/292 (42%), Gaps = 42/292 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +GSG +G + G VA+K + R E + RE+ + +RH N+ Sbjct: 13 YELVRDIGSGNFGVARLMRNRADGQLVAVKYIER---GEKIDENVQREIINHRSLRHPNI 69 Query: 87 IGLLDV-FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 I +V TP T +VM + G ++ + ED +F Q++ G+ Y Sbjct: 70 IRFKEVILTP-------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 122 Query: 144 IHAAGIIHRDLKPGNLAVNEDC--ELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 H+ + HRDLK N ++ LKI DFG ++ + S+ V T Y APEV+L Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 182 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + D+WS G + M+ G F+ D P F + +Q Sbjct: 183 KEYDGKVADVWSCGVTLYVMLVGAYPFEDPDE--------------PKNFRKTIQRILGV 228 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 Y +P D+ I SP +L+ ++ V + R+T E HP+F Sbjct: 229 QY--SIP-----DYVHI----SPECQDLISRIFVANPATRITIPEIRNHPWF 269 >2JDO-A nrPDB Length = 342 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/314 (27%), Positives = 138/314 (43%), Gaps = 38/314 (12%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK----RAYRELRLLKHMRHEN 85 L+ +G G +G V + TG A+K L + + AK E R+L++ RH Sbjct: 15 LKLLGKGTFGKVILVREKATGRYYAMKILRKEV---IIAKDEVAHTVTESRVLQNTRHPF 71 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + L F + L VM + G L + E+R +F +++ L Y Sbjct: 72 LTALKYAFQTHDRL------CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILNW 200 +H+ +++RD+K NL +++D +KI DFGL ++ S+ M + T Y APEV+ + Sbjct: 126 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED- 184 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y + VD W +G +M EM+ G+ F DH + I+ P R S EAK+ Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP-----RTLSPEAKS 239 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 + GL KKD L A ++E L + + L P+ + Sbjct: 240 LLAGLL---KKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPF---------K 287 Query: 321 PQVQKYDDS--FDD 332 PQV D+ FDD Sbjct: 288 PQVTSEVDTRYFDD 301 >3DB8-A nrPDB Length = 317 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 84/294 (28%), Positives = 134/294 (45%), Gaps = 58/294 (19%) Query: 33 VGSGAYGAVCSAVDGRT-----GAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G G + D T G V L +P Q E + E+ + K + + +V+ Sbjct: 50 LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKE----KMSTEIAIHKSLDNPHVV 105 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHEK-LGEDRIQFLVYQMLKGLRYIH 145 G F D DF Y+V+ L +L K K + E ++ + Q ++G++Y+H Sbjct: 106 GFHGFFEDD----DFV--YVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLH 159 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD------SEMTGYVVTRWYRAPEVILN 199 +IHRDLK GNL +N+D ++KI DFGLA + + ++ G T Y APEV+ Sbjct: 160 NNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCG---TPNYIAPEVLCK 216 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 ++ VDIWS+GCI+ ++ GK F+ S LKE Sbjct: 217 -KGHSFEVDIWSLGCILYTLLVGKPPFETS----CLKE---------------------- 249 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Y++ KK+ S+ + +P+A L+ +ML D R + E L +F S Sbjct: 250 TYIR-----IKKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 >2JD5-A nrPDB Length = 373 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 85/329 (25%), Positives = 147/329 (44%), Gaps = 50/329 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH---- 80 A Y ++ +G G + V A D VA+K + +++ + A E++LL+ Sbjct: 19 ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDA 75 Query: 81 -------MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKLGEDRI 130 M +++ LLD F + + +V +G +L L+K H + + Sbjct: 76 DNTKEDSMGANHILKLLDHF--NHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYV 133 Query: 131 QFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVN------EDCELKILDFGLARQADSEMT 183 + + Q+L GL Y+H GIIH D+KP N+ + ++KI D G A D T Sbjct: 134 KQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYT 193 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF---------KGSDHLDQ 234 + TR YR+PEV+L + DIWS C++ E+ITG LF K DH+ Q Sbjct: 194 NSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 235 LKEIMKVTGTPPAEFVQRLQSD----EAKNYMKGLPELEKKDFASILTNASPLA------ 284 + E++ G P+ ++ + ++ ++ + +L+ +LT + Sbjct: 253 IIELL---GELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 285 -VNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + L ML LD +R AG + HP+ + Sbjct: 310 ISDFLSPMLQLDPRKRADAGGLVNHPWLK 338 >3SOA-A nrPDB Length = 444 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 129/294 (43%), Gaps = 44/294 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y+ + +G GA+ V V G + A + S ++ RE R+ + ++H N+ Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNI 72 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L D ++ + YL+ + G ++ E E + Q+L+ + + Sbjct: 73 VRLHD------SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126 Query: 145 HAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVIL 198 H G++HR+LKP NL + + +K+ DFGLA + + E G+ T Y +PEV L Sbjct: 127 HQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV-L 185 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL-QSDE 257 Y + VD+W+ G I+ ++ G F D RL Q + Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ-------------------HRLYQQIK 226 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 227 AGAYDFPSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271 >4QMW-A nrPDB Length = 310 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 112/222 (50%), Gaps = 14/222 (6%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P +SG + K E ++ L+ +G G++G V +D RT VAIK + ++E Sbjct: 12 PVQSGLPGMQNLKADPE--ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIK-IIDLEEAE 68 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEK 124 + +E+ +L V + D T +++M ++G L++ Sbjct: 69 DEIEDIQQEITVLSQCDSPYVTKYYGSYLKD------TKLWIIMEYLGGGSALDLLEPGP 122 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEM- 182 L E +I ++ ++LKGL Y+H+ IHRD+K N+ ++E E+K+ DFG+A Q D+++ Sbjct: 123 LDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK 182 Query: 183 -TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 +V T ++ APEVI Y DIWS+G E+ G+ Sbjct: 183 RNTFVGTPFWMAPEVI-KQSAYDSKADIWSLGITAIELARGE 223 >1ZXE-A nrPDB Length = 303 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 70/250 (28%), Positives = 118/250 (47%), Gaps = 32/250 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + ++ +G GA+G V A + AIKK+ R + +L E+ LL + H+ V Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKI-RHTEEKL--STILSEVMLLASLNHQYV 64 Query: 87 IGLL-------DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQF--LVYQ 136 + + P + + ++ M + L L+ E L + R ++ L Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---------DSE------ 181 +L+ L YIH+ GIIHR+LKP N+ ++E +KI DFGLA+ DS+ Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 182 --MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 +T + T Y A EV+ Y + +D++S+G I EMI G + ++ LK++ Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY--PFSTGMERVNILKKLR 242 Query: 240 KVTGTPPAEF 249 V+ P +F Sbjct: 243 SVSIEFPPDF 252 >4D28-A nrPDB Length = 446 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 101/209 (48%), Gaps = 18/209 (8%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY----RELRLLKHMRHENV 86 + +G G + V A + TG VAIK + + S + R RE+ ++K +RH N+ Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAK---STILKNRMVDQIKREISIMKIVRHPNI 71 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L +V + Y+V+ F+ G +++ +L ED + Q++ + + Sbjct: 72 VRLYEVLASKSKI------YIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHC 125 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSEMTGYVVTRWYRAPEVILNWM 201 H+ G+ HRDLKP NL ++ + LK+ DFGL+ ++ + T Y APEV+ Sbjct: 126 HSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQG 185 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 DIWS G I+ ++ G F +D Sbjct: 186 YDGSAADIWSCGVILFVILAGYLPFSETD 214 >3DLS-A nrPDB Length = 335 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 114/240 (47%), Gaps = 23/240 (9%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP------FQSELFAKRAYRELRLLKH 80 Y + P+GSGA+G V +AVD +V +K + + + + + E+ +L Sbjct: 26 YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR 85 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL---GKLMKHEKLGEDRIQFLVYQM 137 + H N+I +LD+F ++ F LVM G+ L + +H +L E ++ Q+ Sbjct: 86 VEHANIIKVLDIF------ENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQL 139 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV--TRWYRAPE 195 + + Y+ IIHRD+K N+ + ED +K++DFG A + Y T Y APE Sbjct: 140 VSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPE 199 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 V++ +++WS+G +T TL + +L+E ++ PP + L S Sbjct: 200 VLMGNPYRGPELEMWSLG------VTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMS 253 >3HKO-A nrPDB Length = 345 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 88/349 (25%), Positives = 145/349 (41%), Gaps = 86/349 (24%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK---RAYRELRLL 78 E++ Y +G G+YG V A++ +T A AIK + + ++ K R E+RL+ Sbjct: 23 ELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLM 82 Query: 79 KHMRHENVIGLLDVFTPDE-------------TLDDFTDFY------LVMPFMGTDLG-- 117 K + H N+ L +V+ ++ LD F M + T + Sbjct: 83 KKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPC 142 Query: 118 -------------------KLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGN 158 ++ EKL I ++ Q+ L Y+H GI HRD+KP N Sbjct: 143 PECNEEAINGSIHGFRESLDFVQREKL----ISNIMRQIFSALHYLHNQGICHRDIKPEN 198 Query: 159 --LAVNEDCELKILDFGLARQ----ADSE---MTGYVVTRWYRAPEVILNWMR--YTQTV 207 + N+ E+K++DFGL+++ + E MT T ++ APEV LN Y Sbjct: 199 FLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEV-LNTTNESYGPKC 257 Query: 208 DIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPE 267 D WS G ++ ++ G F G + D + +++ + E NY Sbjct: 258 DAWSAGVLLHLLLMGAVPFPGVNDADTISQVL-----------NKKLCFENPNY------ 300 Query: 268 LEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 ++L SPLA +LL +L + ++R A AL HP+ D Sbjct: 301 -------NVL---SPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >5KCV-A nrPDB Length = 460 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 95/344 (27%), Positives = 147/344 (42%), Gaps = 38/344 (11%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRD---LQPVGSGAYGAVCSAVDGRTGAKVAIKKL 58 S P SG EV+ + R + L+ +G G +G V + TG A+K L Sbjct: 136 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 195 Query: 59 YRPFQSELFAK----RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT 114 + + AK E R+L++ RH + L F + L F + G Sbjct: 196 KKEV---IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC----FVMEYANGGE 248 Query: 115 DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVNEDCELKILDFG 173 L + EDR +F +++ L Y+H+ +++RDLK NL +++D +KI DFG Sbjct: 249 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 308 Query: 174 LARQA---DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 L ++ + M + T Y APEV+ + Y + VD W +G +M EM+ G+ F D Sbjct: 309 LCKEGIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYNQD 367 Query: 231 HLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEK 290 H + I+ P R EAK+ + GL KKD L S A ++ Sbjct: 368 HEKLFELILMEEIRFP-----RTLGPEAKSLLSGLL---KKDPKQRLGGGSEDAKEIM-- 417 Query: 291 MLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDS--FDD 332 + R AG H Y + L +PQV D+ FD+ Sbjct: 418 ------QHRFFAGIVWQHVYEKKL-SPPFKPQVTSETDTRYFDE 454 >6CQF-A nrPDB Length = 297 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 103/205 (50%), Gaps = 19/205 (9%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R Y LQ +G G YG V A D +G VA+K + ++ + +E+ +LK RH Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ--KEILILKTCRH 72 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK----HEKLGEDRIQFLVYQMLK 139 N++ + + L ++ M F G G L L E +I ++ ++L+ Sbjct: 73 ANIVAYHGSYLWLQKL------WICMEFCGA--GSLQDIYQVTGSLSELQISYVCREVLQ 124 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEV 196 GL Y+H+ IHRD+K N+ +N+ E+++ DFG++ Q + + ++ T ++ APEV Sbjct: 125 GLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEV 184 Query: 197 ILNWMR--YTQTVDIWSVGCIMAEM 219 ++ Y + DIWS+G E+ Sbjct: 185 AAVALKGGYNELCDIWSLGITAIEL 209 >6CCF-A nrPDB Length = 290 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 51/174 (29%), Positives = 94/174 (54%), Gaps = 14/174 (8%) Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 P + L +R Y+E+ +LK + H NV+ L++V D+ +D + YLV + G +M Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL--DDPAED--NLYLVFDLLRK--GPVM 118 Query: 121 K---HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ 177 + + E++ + + ++ GL Y+H I+HRD+KP NL + +D +KI DFG++ Q Sbjct: 119 EVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ 178 Query: 178 ---ADSEMTGYVVTRWYRAPEVILNWMR--YTQTVDIWSVGCIMAEMITGKTLF 226 D++++ T + APE I + + + +D+W+ G + + GK F Sbjct: 179 FEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF 232 >3DAK-A nrPDB Length = 290 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 82/311 (26%), Positives = 129/311 (41%), Gaps = 47/311 (15%) Query: 21 WEVRAVYRDLQPV-GSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 W + +LQ V GSGA V +A KVAIK++ + + +E++ + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLE-KCQTSMDELLKEIQAMS 63 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---------EKLGEDR 129 H N++ F + L +LVM + G + ++KH L E Sbjct: 64 QCHHPNIVSYYTSFVVKDEL------WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 117 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG----LARQADSEMT-- 183 I ++ ++L+GL Y+H G IHRD+K GN+ + ED ++I DFG LA D Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 177 Query: 184 --GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 +V T + APEV+ Y DIWS G E+ TG + + L ++ + Sbjct: 178 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL--MLTL 235 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 PP+ + K Y K + ++ L D E+R T Sbjct: 236 QNDPPSLETGVQDKEMLKKYGKSFRK-------------------MISLCLQKDPEKRPT 276 Query: 302 AGEALAHPYFE 312 A E L H +F+ Sbjct: 277 AAELLRHKFFQ 287 >2WTK-C nrPDB Length = 305 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 71/257 (27%), Positives = 119/257 (46%), Gaps = 24/257 (9%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--RELRLLKHMRHENVIGLL 90 +G G+YG V +D T + A+K L + + A +E++LL+ +RH+NVI L+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL-----VYQMLKGLRYIH 145 DV +E Y+VM + + +++ + + E R Q++ GL Y+H Sbjct: 73 DVLYNEEK----QKMYMVMEYCVCGMQEML--DSVPEKRFPVCQAHGYFCQLIDGLEYLH 126 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLAR-----QADSEMTGYVVTRWYRAPEVILNW 200 + GI+H+D+KPGNL + LKI G+A AD + ++ PE+ Sbjct: 127 SQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGL 186 Query: 201 MRYTQ-TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 ++ VDIWS G + + TG F+G + + I K + P + L Sbjct: 187 DTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLS----- 241 Query: 260 NYMKGLPELEKKDFASI 276 + +KG+ E E SI Sbjct: 242 DLLKGMLEYEPAKRFSI 258 >5O0Y-A nrPDB Length = 579 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 84/266 (31%), Positives = 123/266 (46%), Gaps = 41/266 (15%) Query: 38 YGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 + V A D VA+K K +R + E + K A RE R+ K + H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 93 FTPDETLDDFTD-FYLVMPFM-GTDLGKLMKHEKL-GEDRIQFLVYQMLKGLRYIHAAG- 148 F+ D TD F V+ + G DL +K KL E + ++ Q++ L+Y++ Sbjct: 357 FSLD------TDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKP 410 Query: 149 -IIHRDLKPGN-LAVN-EDC-ELKILDFGLARQADSEMTGYV----------VTRWYRAP 194 IIH DLKPGN L VN C E+KI DFGL++ D + V T WY P Sbjct: 411 PIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP 470 Query: 195 EVILNWM---RYTQTVDIWSVGCIMAEMITGKTLF-KGSDHLDQLKE--IMKVTGT--PP 246 E + + + VD+WSVG I + + G+ F D L+E I+K T PP Sbjct: 471 ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPP 530 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKD 272 V + EAK +++ K+D Sbjct: 531 KPVV----TPEAKAFIRRCLAYRKED 552 >5J5T-A nrPDB Length = 370 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 56/197 (28%), Positives = 101/197 (51%), Gaps = 15/197 (7%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +Q +GSG YG V A + TG AIK + + E FA +E+ ++K +H N++ Sbjct: 9 IQRIGSGTYGDVYKARNVNTGELAAIK-VIKLEPGEDFAV-VQQEIIMMKDCKHPNIVAY 66 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAA 147 + + L ++ M F G + + H L E +I ++ + L+GL Y+H+ Sbjct: 67 FGSYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEVILNWMR-- 202 G +HRD+K N+ + ++ +K+ DFG++ Q + + ++ T ++ APEV + Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 203 YTQTVDIWSVGCIMAEM 219 Y Q D+W+VG E+ Sbjct: 181 YNQLCDLWAVGITAIEL 197 >3A4O-X nrPDB Length = 286 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 72/240 (30%), Positives = 121/240 (50%), Gaps = 19/240 (7%) Query: 18 KTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 K AWE+ R + ++ +G+G +G V + KVA+K L +P + + E Sbjct: 5 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTL-KP--GTMSVQAFLEEAN 60 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYL---VMPFMGTDLGKLMKHEKLGEDRIQFL 133 L+K ++H+ ++ L V T +E + T++ ++ F+ +D G + KL I F Sbjct: 61 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKL----IDFS 116 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW-- 190 Q+ +G+ YI IHRDL+ N+ V+E KI DFGLAR D+E T ++ Sbjct: 117 A-QIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPI 175 Query: 191 -YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAE 248 + APE I N+ +T D+WS G ++ E++T GK + G + D + + + P E Sbjct: 176 KWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE 234 >4WB7-A nrPDB Length = 405 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 111/235 (47%), Gaps = 18/235 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + ++ +G+G++G V TG A+K + K+ +L+ ++H +E Sbjct: 98 FERIKTLGTGSFGRVMLVKHKETGNHYAMK---------ILDKQKVVKLKQIEHTLNEKR 148 Query: 87 IGLLDVFTP-----DETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 I L V P + + D ++ Y+VM ++ G L + + E +F Q++ Sbjct: 149 I-LQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 207 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILN 199 Y+H+ +I+RDLKP NL +++ +++ DFG A++ T Y APE+IL+ Sbjct: 208 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS 267 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 Y + VD W++G ++ EM G F + ++I+ P+ F L+ Sbjct: 268 -KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 321 >2XNP-A nrPDB Length = 279 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 108/208 (51%), Gaps = 21/208 (10%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAI-KKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y L +G+G+YG C + ++ K+ + K+L +E + E+ LL+ ++H N Sbjct: 8 YEVLYTIGTGSYGR-CQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM-----KHEKLGEDRIQFLVYQMLK 139 ++ D D T T Y+VM + G DL ++ + + L E+ + ++ Q+ Sbjct: 67 IVRYYDRII-DRT---NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122 Query: 140 GLRYIH-----AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWY 191 L+ H ++HRDLKP N+ ++ +K+ DFGLAR + + + +V T +Y Sbjct: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYY 182 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEM 219 +PE +N M Y + DIWS+GC++ E+ Sbjct: 183 MSPEQ-MNRMSYNEKSDIWSLGCLLYEL 209 >3MV5-A nrPDB Length = 342 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 93/337 (27%), Positives = 145/337 (43%), Gaps = 45/337 (13%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK----RAYRELRLLKHMRHEN 85 L+ +G G +G V + TG A+K L + + AK E R+L++ RH Sbjct: 15 LKLLGKGTFGKVILVKEKATGRYYAMKILKKEV---IVAKDEVAHTLTENRVLQNSRHPF 71 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + L F + L VM + G L + EDR +F +++ L Y Sbjct: 72 LTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 144 IHA-AGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 +H+ +++RDLK NL +++D +KI DFGL ++ + M + T Y APEV+ + Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y + VD W +G +M EM+ G+ F DH + I+ P R EAK Sbjct: 186 -NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP-----RTLGPEAK 239 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 + + GL KKD L S A ++ + R AG H Y + L Sbjct: 240 SLLSGLL---KKDPKQRLGGGSEDAKEIM--------QHRFFAGIVWQHVYEKKL-SPPF 287 Query: 320 EPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 +PQV D+ R DE ++++ PP Q Sbjct: 288 KPQVTSETDT-----RYFDEEFTA---QMITITPPDQ 316 >2BRG-A nrPDB Length = 297 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 77/278 (27%), Positives = 125/278 (44%), Gaps = 40/278 (14%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +Q +G GAYG V AV+ T VA+K + + + +E+ + K + HENV+ Sbjct: 12 VQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDC-PENIKKEICINKMLNHENVVK- 69 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 F + +L G ++ + E Q +Q++ G+ Y+H GI Sbjct: 70 ---FYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLA---RQADSE--MTGYVVTRWYRAPEVILNWMRYT 204 HRD+KP NL ++E LKI DFGLA R + E + T Y APE++ + Sbjct: 127 THRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHA 186 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS-DEAKNYMK 263 + VD+WS G ++ M+ G+ + DQ P++ Q E K Y+ Sbjct: 187 EPVDVWSCGIVLTAMLAGELPW------DQ-----------PSDSCQEYSDWKEKKTYLN 229 Query: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 +++ ++PLA LL K+LV + R+T Sbjct: 230 PWKKID----------SAPLA--LLHKILVENPSARIT 255 >2WQN-A nrPDB Length = 310 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 104/220 (47%), Gaps = 19/220 (8%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA--YRELRL 77 + A +R + +G G + V A G VA+KK+ + F RA +E+ L Sbjct: 27 GYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKV-QIFDLMDAKARADCIKEIDL 85 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK-----LGEDRIQ 131 LK + H NVI F D L+ +V+ DL +++KH K + E + Sbjct: 86 LKQLNHPNVIKYYASFIEDNELN------IVLELADAGDLSRMIKHFKKQKRLIPERTVW 139 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG---YVVT 188 Q+ L ++H+ ++HRD+KP N+ + +K+ D GL R S+ T V T Sbjct: 140 KYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGT 199 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG 228 +Y +PE I + Y DIWS+GC++ EM ++ F G Sbjct: 200 PYYMSPERI-HENGYNFKSDIWSLGCLLYEMAALQSPFYG 238 >6FDY-U nrPDB Length = 276 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 135/292 (46%), Gaps = 46/292 (15%) Query: 33 VGSGAYGAVCSAVDGR-TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +GSG Y V A + T VAIK + + ++ + E+ +LK +RH +++ L D Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKD 78 Query: 92 VFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRI-QFLVYQMLKGLRYIHAAGI 149 D + YL+M F G DL + + ++ +++ + + Q+ L+++H I Sbjct: 79 FQW------DSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNI 132 Query: 150 IHRDLKPGNLAVN--EDCELKILDFGLARQADSEMTGYVV--TRWYRAPEVILNWMRYTQ 205 H DLKP N+ ++ E LK+ DFG A+ +V+ + Y APE++ +Y Sbjct: 133 SHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQ-RQYDA 191 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 VD+WS+G I+ E + G+ F S +L+E ++ N + L Sbjct: 192 RVDLWSMGVILYEALFGQPPF-ASRSFSELEEKIR------------------SNRVIEL 232 Query: 266 P--ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 P L +D +LL+++L D +R++ + AHP+ + H Sbjct: 233 PLRPLLSRD-----------CRDLLQRLLERDPSRRISFQDFFAHPWVDLEH 273 >2H8H-A nrPDB Length = 535 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 123/244 (50%), Gaps = 23/244 (9%) Query: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAV-DGRTGAKVAIKKLYRPFQSELFAKRA 71 Q + K AWE+ R R +G G +G V +G T +VAIK L +P + + Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT--RVAIKTL-KP--GTMSPEAF 309 Query: 72 YRELRLLKHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR 129 +E +++K +RHE ++ L V + P + ++ ++ F+ + GK ++ +L + Sbjct: 310 LQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD-- 367 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVT 188 + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T Sbjct: 368 ---MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 424 Query: 189 RW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG---SDHLDQLKEIMKV 241 ++ + APE L + R+T D+WS G ++ E+ T G+ + G + LDQ++ ++ Sbjct: 425 KFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 483 Query: 242 TGTP 245 P Sbjct: 484 PCPP 487 >3ZUT-A nrPDB Length = 362 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 123/293 (41%), Gaps = 44/293 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +GSG +G D ++ VA+K + R E + RE+ + +RH N+ Sbjct: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHPNI 77 Query: 87 IGLLDV-FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + +V TP T +VM + G ++ + ED +F Q++ G+ Y Sbjct: 78 VRFKEVILTP-------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 HA + HRDLK N ++ LKI FG ++ + S+ V T Y APEV+L Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLK 190 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + D+WS G + M+ G F+ +E K Sbjct: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFE--------------------------DPEEPK 224 Query: 260 NYMKGLPELEKKDFA-SILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 N+ K + + +A + SP +L+ ++ V D +R++ E H +F Sbjct: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >3LM0-A nrPDB Length = 327 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 79/313 (25%), Positives = 145/313 (46%), Gaps = 50/313 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLD 91 +G G + V + TG + A K L + + + E+ +L+ + VI L + Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHE 96 Query: 92 VFTPDETLDDFTDFYLVMPFM-GTDLGKLMK---HEKLGEDRIQFLVYQMLKGLRYIHAA 147 V+ ++ ++ L++ + G ++ L E + E+ + L+ Q+L+G+ Y+H Sbjct: 97 VY------ENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQN 150 Query: 148 GIIHRDLKPGNLAVNED---CELKILDFGLARQAD--SEMTGYVVTRWYRAPEVILNWMR 202 I+H DLKP N+ ++ ++KI+DFG++R+ E+ + T Y APE ILN+ Sbjct: 151 NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE-ILNYDP 209 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 T D+W++G I ++T + F G D+ + I +V Sbjct: 210 ITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVN-------------------- 249 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY-----FESL-HD 316 + ++ F+S+ S LA + ++ +LV + E+R TA L+H + FE+L H Sbjct: 250 ---VDYSEETFSSV----SQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHP 302 Query: 317 TEDEPQVQKYDDS 329 E Q D S Sbjct: 303 EETSSSSQTQDHS 315 >4JXF-A nrPDB Length = 266 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 68/287 (23%), Positives = 127/287 (44%), Gaps = 49/287 (17%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G++ V A TG +VAIK + + +R E+++ ++H +++ L + Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYN 74 Query: 92 VFTPDETLDDFTDFYLVMPFMGT-DLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAAG 148 F +D YLV+ ++ + +K+ + E+ + ++Q++ G+ Y+H+ G Sbjct: 75 YF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 128 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV---TRWYRAPEVILNWMRYTQ 205 I+HRDL NL + + +KI DFGLA Q + T Y +PE+ + Sbjct: 129 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE 188 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG- 264 + D+WS+GC+ ++ G+ PP +D KN + Sbjct: 189 S-DVWSLGCMFYTLLIGR---------------------PP------FDTDTVKNTLNKV 220 Query: 265 -LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 L + E F SI A +L+ ++L + R++ L HP+ Sbjct: 221 VLADYEMPSFLSI------EAKDLIHQLLRRNPADRLSLSSVLDHPF 261 >3UDB-A nrPDB Length = 317 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 123/293 (41%), Gaps = 44/293 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +G+G +G D + VA+K + R E + RE+ + +RH N+ Sbjct: 21 YELVKDIGAGNFGVARLMRDKQANELVAVKYIER---GEKIDENVKREIINHRSLRHPNI 77 Query: 87 IGLLDV-FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + +V TP T +VM + G ++ + ED +F Q++ G+ Y Sbjct: 78 VRFKEVILTP-------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 HA + HRDLK N ++ LKI DFG ++ + S+ V T Y APEV+L Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLK 190 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + D+WS G + M+ G F+ +E K Sbjct: 191 KEYDGKVADVWSCGVTLYVMLVGAYPFE--------------------------DPEEPK 224 Query: 260 NYMKGLPELEKKDFA-SILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 N+ K + + +A + SP +L+ ++ V D +R++ E H +F Sbjct: 225 NFRKTIHRILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >4UY9-A nrPDB Length = 323 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 106/216 (49%), Gaps = 26/216 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL--FAKRAYRELRLLKHMRHENVIGLL 90 +G G +G V A G +VA+K ++ + +E +L ++H N+I L Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 V + L LVM F G L +++ +++ D + Q+ +G+ Y+H I Sbjct: 75 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 128 Query: 150 ---IHRDLKPGNLAVNEDCE--------LKILDFGLARQ--ADSEMTGYVVTRWYRAPEV 196 IHRDLK N+ + + E LKI DFGLAR+ ++M+ W APEV Sbjct: 129 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM-APEV 187 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 I M +++ D+WS G ++ E++TG+ F+G D L Sbjct: 188 IRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 222 >6F3F-A nrPDB Length = 455 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 122/245 (49%), Gaps = 25/245 (10%) Query: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP--FQSELFAKR 70 Q + K AWE+ R R +G G +G V T +VAIK L +P E F + Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL-KPGTMSPEAFLQE 232 Query: 71 AYRELRLLKHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 A +++K +RHE ++ L V + P + ++ + ++ F+ + GK ++ +L + Sbjct: 233 A----QVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVD- 287 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVV 187 + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T Sbjct: 288 ----MSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 343 Query: 188 TRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG---SDHLDQLKEIMK 240 ++ + APE L + R+T D+WS G ++ E+ T G+ + G + LDQ++ + Sbjct: 344 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 402 Query: 241 VTGTP 245 + P Sbjct: 403 MPCPP 407 >5SYS-A nrPDB Length = 286 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/243 (27%), Positives = 121/243 (49%), Gaps = 21/243 (8%) Query: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY 72 Q + K AWE+ R R +G G +G C +VAIK L +P + + Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGE-CWMGTWNGTTRVAIKTL-KP--GTMSPEAFL 61 Query: 73 RELRLLKHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130 +E +++K +RHE ++ L V + P + ++ ++ F+ ++GK ++ +L + Sbjct: 62 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVD--- 118 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTR 189 + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T + Sbjct: 119 --MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 176 Query: 190 W---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG---SDHLDQLKEIMKVT 242 + + APE L + R+T D+WS G ++ E+ T G+ + G + LDQ++ ++ Sbjct: 177 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 235 Query: 243 GTP 245 P Sbjct: 236 CPP 238 >6E9W-A nrPDB Length = 443 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/224 (29%), Positives = 103/224 (45%), Gaps = 17/224 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--RELRLLKHMRHE 84 Y ++ +G GA+G V V ++ KV KL F+ + A+ E ++ Sbjct: 104 YEVVKVIGRGAFGEV-QLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 162 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 V+ L F D L Y+VM +M G DL LM + + E +F +++ L Sbjct: 163 WVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDA 216 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILN 199 IH+ G IHRD+KP N+ +++ LK+ DFG + + E V T Y +PEV+ + Sbjct: 217 IHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS 276 Query: 200 W---MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Y + D WSVG + EM+ G T F + +IM Sbjct: 277 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN 320 >5X3F-B nrPDB Length = 393 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 110/232 (47%), Gaps = 18/232 (7%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 ++ +G+G++G V +G A+K + K+ +L+ ++H +E I L Sbjct: 89 IKTLGTGSFGRVMLVKHKESGNHYAMK---------ILDKQKVVKLKQIEHTLNEKRI-L 138 Query: 90 LDVFTP-----DETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 V P + + D ++ Y+VM ++ G L + + E +F Q++ Sbjct: 139 QAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 198 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMR 202 Y+H+ +I+RDLKP NL +++ +++ DFG A++ T Y APE+IL+ Sbjct: 199 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-KG 257 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 Y + VD W++G ++ EM G F + ++I+ P+ F L+ Sbjct: 258 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 309 >4YHJ-A nrPDB Length = 584 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/260 (29%), Positives = 124/260 (47%), Gaps = 21/260 (8%) Query: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-A 71 RQ VTK +R + +G G +G VC+ TG A KKL + + + A Sbjct: 179 RQPVTKN------TFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMA 232 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG---KLMKHEKLGE 127 E R+L+ ++ V+ L + ET D LV+ M G DL + + E Sbjct: 233 LNEKRILEKVQSRFVVSLAYAY---ETKDALC---LVLTIMNGGDLKFHIYNLGNPGFDE 286 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGY 185 R F ++ GL + I++RDLKP N+ +++ ++I D GLA + + G Sbjct: 287 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGR 346 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 V T Y APEV+ N +YT + D W +GC++ EMI G + FK + +E+ + Sbjct: 347 VGTVGYMAPEVVNN-EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKND 405 Query: 246 PAEFVQRLQSDEAKNYMKGL 265 E+ ++ S++AK+ + L Sbjct: 406 TEEYSEKF-SEDAKSICRML 424 >3DTC-A nrPDB Length = 271 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 106/216 (49%), Gaps = 26/216 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL--FAKRAYRELRLLKHMRHENVIGLL 90 +G G +G V A G +VA+K ++ + +E +L ++H N+I L Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH---A 146 V + L LVM F G L +++ +++ D + Q+ +G+ Y+H Sbjct: 73 GVCLKEPNL------CLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAI 126 Query: 147 AGIIHRDLKPGNLAVNEDCE--------LKILDFGLARQ--ADSEMTGYVVTRWYRAPEV 196 IIHRDLK N+ + + E LKI DFGLAR+ ++M+ W APEV Sbjct: 127 VPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM-APEV 185 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 I M +++ D+WS G ++ E++TG+ F+G D L Sbjct: 186 IRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGL 220 >4FR4-A nrPDB Length = 384 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 101/200 (50%), Gaps = 11/200 (5%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-AYRELRLLKHMRHENVIG 88 L+ +G G++G VC T A+K + + E R ++EL++++ + H ++ Sbjct: 20 LRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVN 79 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 L F +E + F +V +G DL L ++ E+ ++ + +++ L Y+ Sbjct: 80 LWYSFQDEEDM-----FMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQ 134 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN--WMRY 203 IIHRD+KP N+ ++E + I DF +A ++++T T+ Y APE+ + Y Sbjct: 135 RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGY 194 Query: 204 TQTVDIWSVGCIMAEMITGK 223 + VD WS+G E++ G+ Sbjct: 195 SFAVDWWSLGVTAYELLRGR 214 >1S9I-A nrPDB Length = 354 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 103/223 (46%), Gaps = 16/223 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + + +G+G G V + V R + +KL + REL++L + Sbjct: 18 FERISELGAGN-GGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYI 76 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYI 144 +G F D + + M M G L +++K K + E+ + + +L+GL Y+ Sbjct: 77 VGFYGAFYSD------GEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYL 130 Query: 145 HAAG-IIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMR 202 I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y APE L Sbjct: 131 REKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPER-LQGTH 189 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 Y+ DIWS+G + E+ G+ D KE+ + G P Sbjct: 190 YSVQSDIWSMGLSLVELAVGRYPIPPPD----AKELEAIFGRP 228 >1FOT-A nrPDB Length = 318 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 108/226 (47%), Gaps = 10/226 (4%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL-LKHMRHEN 85 ++ L+ +G+G++G V G A+K L + L + RL L + H Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM-KHEKLGEDRIQFLVYQMLKGLRY 143 +I + F D +++M ++ G +L L+ K ++ +F ++ L Y Sbjct: 68 IIRMWGTF------QDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRY 203 +H+ II+RDLKP N+ ++++ +KI DFG A+ T Y APEV+ + Y Sbjct: 122 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVV-STKPY 180 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 +++D WS G ++ EM+ G T F S+ + ++I+ P F Sbjct: 181 NKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFF 226 >5FET-A nrPDB Length = 847 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 67/238 (28%), Positives = 111/238 (46%), Gaps = 16/238 (6%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN----VIG 88 +G G +G V T + A+K + + + + ++L + + EN +I Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSK---RSIISLNQQNNIKLEREITAENDHPFIIR 597 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 L+ F ++L G +L + K L + + QF + ++ + Y+H Sbjct: 598 LVRTFKDSNCF-----YFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHER 652 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTV 207 I++RDLKP N+ +++ +K++DFG A++ V T Y APEVIL Y TV Sbjct: 653 NIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG-KGYGCTV 711 Query: 208 DIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 DIW++G + E I G F G+D DQL EI + T F + ++ N MK L Sbjct: 712 DIWALGVCLYEFICGPLPF-GNDQEDQL-EIFRDILTGQLTFPDYVSDQDSINLMKRL 767 >5VO2-A nrPDB Length = 300 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 68/211 (32%), Positives = 105/211 (49%), Gaps = 32/211 (15%) Query: 29 DLQPVGSGAYGAVCSAVDGR-TGAKVAIKKLYRPFQSELFAKRAYRE--LRLLKHMRHEN 85 DLQ VGSGA GAV GR G +VA+KK+ R +E ++ L+ ++H N Sbjct: 16 DLQWVGSGAQGAV---FLGRFHGEEVAVKKV-----------RDLKETDIKHLRKLKHPN 61 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQ----MLKGL 141 +I V T + ++M F G+L + + G L+ + G+ Sbjct: 62 IITFKGVCTQAPC------YCILMEFCAQ--GQLYEVLRAGRPVTPSLLVDWSMGIAGGM 113 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT--GYVVTRWYRAPEVILN 199 Y+H IIHRDLK N+ + D +KI DFG +++ + T + T + APEVI N Sbjct: 114 NYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN 173 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 ++ VDIWS G ++ E++TG+ +K D Sbjct: 174 -EPVSEKVDIWSFGVVLWELLTGEIPYKDVD 203 >6ED6-A nrPDB Length = 415 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 68/225 (30%), Positives = 104/225 (46%), Gaps = 21/225 (9%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--RELRLLKHMRHE 84 Y ++ +G GA+G V V + KV KL F+ + A+ E ++ Sbjct: 90 YDVVKVIGRGAFGEV-QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 148 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 V+ L F D L Y+VM +M G DL LM + + E +F +++ L Sbjct: 149 WVVQLFYAFQDDRYL------YMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDA 202 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------VVTRWYRAPEVI 197 IH+ G+IHRD+KP N+ +++ LK+ DFG + D TG V T Y +PEV+ Sbjct: 203 IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDE--TGMVHCDTAVGTPDYISPEVL 260 Query: 198 LNWMR---YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 + Y + D WSVG + EM+ G T F + +IM Sbjct: 261 KSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM 305 >2W1I-A nrPDB Length = 326 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 125/275 (45%), Gaps = 49/275 (17%) Query: 6 PARSGFYRQEVTKTAWEVR-------AVYRDLQPVGSGAYGAV--C--SAVDGRTGAKVA 54 P Y Q +A+E R + LQ +G G +G+V C + TG VA Sbjct: 15 PTTENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA 74 Query: 55 IKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-- 112 +KKL + L + RE+ +LK ++H+N++ V + L+M ++ Sbjct: 75 VKKLQHSTEEHL--RDFEREIEILKSLQHDNIVKYKGVCYSAGR----RNLKLIMEYLPY 128 Query: 113 GTDLGKLMKH-EKLGEDRIQFLVY--QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKI 169 G+ L KH E++ D I+ L Y Q+ KG+ Y+ IHRDL N+ V + +KI Sbjct: 129 GSLRDYLQKHKERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKI 186 Query: 170 LDFGLARQADSEMTGYVVTR-------WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 DFGL + + Y V WY APE L +++ D+WS G ++ E+ T Sbjct: 187 GDFGLTKVLPQDKEYYKVKEPGESPIFWY-APES-LTESKFSVASDVWSFGVVLYELFT- 243 Query: 223 KTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 ++ + +PPAEF++ + +D+ Sbjct: 244 ---------------YIEKSKSPPAEFMRMIGNDK 263 >6BDL-A nrPDB Length = 347 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 106/214 (49%), Gaps = 12/214 (5%) Query: 60 RPFQSELFAKRAYRELRLLKHMRHENVI--GLLDVFTPD--ETLDDFTDFYLVM-PFMGT 114 + F ++ KR + R +H+R E I G F T D Y++M +G Sbjct: 61 KTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGG 120 Query: 115 DLGKLMKHEKLGEDRI-QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 +L +++ ED +F +++ Y+H+ GII+RDLKP NL ++ K++DFG Sbjct: 121 ELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFG 180 Query: 174 LARQA--DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDH 231 A++ + + T Y APE+ILN + + D WS+G +M E++TG F G D Sbjct: 181 FAKKIGFGKKTWTFCGTPEYVAPEIILN-KGHDISADYWSLGILMYELLTGSPPFSGPDP 239 Query: 232 LDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 + I++ G EF +++ + A N +K L Sbjct: 240 MKTYNIILR--GIDMIEFPKKIAKNAA-NLIKKL 270 >5DYK-A nrPDB Length = 853 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 50/141 (35%), Positives = 76/141 (53%), Gaps = 3/141 (2%) Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG 184 L + + QF + ++ + Y+H I++RDLKP N+ +++ +K++DFG A++ Sbjct: 636 LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYT 695 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 V T Y APEVIL Y TVDIW++G + E I G F G+D DQL EI + T Sbjct: 696 LVGTPHYMAPEVILG-KGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQL-EIFRDILT 752 Query: 245 PPAEFVQRLQSDEAKNYMKGL 265 F + ++ N MK L Sbjct: 753 GQLTFPDYVTDTDSINLMKRL 773 >3UC3-A nrPDB Length = 361 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 120/296 (40%), Gaps = 50/296 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y ++ +GSG +G D T VA+K + R + RE+ + +RH N+ Sbjct: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREIINHRSLRHPNI 78 Query: 87 IGLLDV-FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + +V TP T ++M + G ++ + ED +F Q+L G+ Y Sbjct: 79 VRFKEVILTP-------THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 Query: 144 IHAAGIIHRDLKPGNLAVNED--CELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 H+ I HRDLK N ++ LKI DFG ++ + S+ V T Y APEV+L Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLR 191 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGS----DHLDQLKEIMKVTGTPPAEFVQRLQS 255 + D+WS G + M+ G F+ D+ ++ I+ V + P + Sbjct: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI------ 245 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 SP +L+ ++ V D R++ E H +F Sbjct: 246 -----------------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >2DQ7-X nrPDB Length = 283 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 68/234 (29%), Positives = 118/234 (50%), Gaps = 28/234 (11%) Query: 18 KTAWEV-RAVYRDLQPVGSGAYGAVCSAV-DGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 K WE+ R + ++ +G+G +G V +G T KVAIK L +P + + E Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT--KVAIKTL-KP--GTMSPESFLEEA 55 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR------ 129 +++K ++H+ ++ L V + + Y+V +M + G L+ K GE R Sbjct: 56 QIMKKLKHDKLVQLYAVVSEE-------PIYIVTEYM--NKGSLLDFLKDGEGRALKLPN 106 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVT 188 + + Q+ G+ YI IHRDL+ N+ V KI DFGLAR D+E T Sbjct: 107 LVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGA 166 Query: 189 RW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 ++ + APE L + R+T D+WS G ++ E++T G+ + G ++ + L+++ Sbjct: 167 KFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 219 >3ALO-A nrPDB Length = 327 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 79/297 (26%), Positives = 132/297 (44%), Gaps = 45/297 (15%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +DL +G GAYG+V V +G +A+K++ R E K+ +L ++ MR + Sbjct: 25 KDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVV--MRSSDCP 81 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLKGL 141 ++ + L D ++ M M T K K+ + + E+ + + +K L Sbjct: 82 YIVQFYG---ALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKAL 138 Query: 142 RYI-HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADS-EMTGYVVTRWYRAPEVI- 197 ++ IIHRD+KP N+ ++ +K+ DFG++ Q DS T R Y APE I Sbjct: 139 NHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID 198 Query: 198 --LNWMRYTQTVDIWSVGCIMAEMITGKTLF-KGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 + Y D+WS+G + E+ TG+ + K + DQL +++K G PP Sbjct: 199 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQ------- 249 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 L E+++F SP +N + L D +R E L HP+ Sbjct: 250 ----------LSNSEEREF-------SPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >3IO7-A nrPDB Length = 313 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 73/255 (28%), Positives = 122/255 (47%), Gaps = 43/255 (16%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAV--C--SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 T +E R + + LQ +G G +G+V C + TG VA+KKL + L + RE Sbjct: 23 TQFEERHL-KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL--RDFERE 79 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKH-EKLGEDRIQ 131 + +LK ++H+N++ V + L+M ++ G+ L KH E++ D I+ Sbjct: 80 IEILKSLQHDNIVKYKGVCYSAGR----RNLKLIMEYLPYGSLRDYLQKHKERI--DHIK 133 Query: 132 FLVY--QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR 189 L Y Q+ KG+ Y+ IHRDL N+ V + +KI DFGL + + Y V Sbjct: 134 LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKE 193 Query: 190 -------WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT 242 WY APE L +++ D+WS G ++ E+ T ++ + Sbjct: 194 PGESPIFWY-APES-LTESKFSVASDVWSFGVVLYELFT----------------YIEKS 235 Query: 243 GTPPAEFVQRLQSDE 257 +PPAEF++ + +D+ Sbjct: 236 KSPPAEFMRMIGNDK 250 >2PL0-A nrPDB Length = 289 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 111/217 (51%), Gaps = 20/217 (9%) Query: 21 WEV-RAVYRDLQPVGSGAYGAVCSAV-DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 WEV R + ++ +G+G +G V +G T KVA+K L Q + E L+ Sbjct: 18 WEVPRETLKLVERLGAGQFGEVWMGYYNGHT--KVAVKSLK---QGSMSPDAFLAEANLM 72 Query: 79 KHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQ 136 K ++H+ ++ L V T P + ++ + ++ F+ T G KL +++ + Q Sbjct: 73 KQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGI-----KLTINKLLDMAAQ 127 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRW---YR 192 + +G+ +I IHRDL+ N+ V++ KI DFGLAR D+E T ++ + Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 187 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 APE I N+ +T D+WS G ++ E++T G+ + G Sbjct: 188 APEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPG 223 >4UYA-A nrPDB Length = 340 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 106/216 (49%), Gaps = 26/216 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQ-SELFAKRAYRELRLLKHMRHENVIGLL 90 +G+G +G V A G +VA+K + P Q + A+ RE RL +RH N+I L Sbjct: 34 IGAGGFGQVYRAT--WQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELR 91 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG- 148 V L LV+ F G L + + ++ + Q+ +G+ Y+H Sbjct: 92 GVCLQQPHL------CLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYLHEEAF 145 Query: 149 --IIHRDLKPGNLAVNEDCE--------LKILDFGLARQ--ADSEMTGYVVTRWYRAPEV 196 I+HRDLK N+ + E E LKI DFGLAR+ ++M W APEV Sbjct: 146 VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM-APEV 204 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 I + + +++ DIWS G ++ E++TG+ ++G D L Sbjct: 205 IKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGL 239 >5HI2-A nrPDB Length = 283 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/278 (26%), Positives = 130/278 (46%), Gaps = 43/278 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 Q +GSG++G V G+ VA+K L P Q + F E+ +L+ RH N++ + Sbjct: 26 QRIGSGSFGTV---YKGKWHGDVAVKML-TPQQLQAFKN----EVGVLRKTRHVNILLFM 77 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF-----LVYQMLKGLRYIH 145 T + L + + L H E + + + Q +G+ Y+H Sbjct: 78 GYSTKPQ---------LAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLH 128 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLA----RQADS----EMTGYVVTRWYRAPEVI 197 A IIHRDLK N+ ++ED +KI DFGLA R + S +++G ++ + APEVI Sbjct: 129 AKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSIL---WMAPEVI 185 Query: 198 --LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 + Y+ D+++ G ++ E++TG+ + ++ DQ+ E++ P + +++S Sbjct: 186 RMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPD--LSKVRS 243 Query: 256 DEAKNYMKGLPELEKK------DFASILTNASPLAVNL 287 + K + + E KK F IL LA L Sbjct: 244 NCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >3HDN-A nrPDB Length = 373 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 109/224 (48%), Gaps = 20/224 (8%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR-----LLKHM 81 + L+ +G G++G V A A+K L + + K+ + + LLK++ Sbjct: 40 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQK---KAILKKKEEKHIMSERNVLLKNV 96 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK-LGEDRIQFLVYQMLK 139 +H ++GL F + L Y V+ ++ G +L ++ E+ E R +F ++ Sbjct: 97 KHPFLVGLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARFYAAEIAS 150 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEV 196 L Y+H+ I++RDLKP N+ ++ + + DFGL ++ +S + + T Y APEV Sbjct: 151 ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV 210 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 L+ Y +TVD W +G ++ EM+ G F + + I+ Sbjct: 211 -LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 253 >6GVJ-A nrPDB Length = 429 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 131/307 (42%), Gaps = 58/307 (18%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRH- 83 +Y L+ +GSG V ++ + ++ K +++ +YR E+ L ++ Sbjct: 145 IYSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 202 Query: 84 -ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVY--QMLKG 140 + +I L D D+ + Y+VM DL +K +K D + Y ML+ Sbjct: 203 SDKIIRLYDYEITDQYI------YMVMECGNIDLNSWLKKKK-SIDPWERKSYWKNMLEA 255 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-----TRWYRAPE 195 + IH GI+H DLKP N + D LK++DFG+A Q + T V T Y PE Sbjct: 256 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 196 VILNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 I + + D+WS+GCI+ M GKT F+ ++Q+ ++ + Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQI--INQISKLHAIIDP- 371 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 N+ P++ +KD + L+ L D +QR++ E Sbjct: 372 --------------NHEIEFPDIPEKDLQDV-----------LKCCLKRDPKQRISIPEL 406 Query: 306 LAHPYFE 312 LAHPY + Sbjct: 407 LAHPYVQ 413 >5N23-A nrPDB Length = 352 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/235 (23%), Positives = 109/235 (46%), Gaps = 17/235 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM----R 82 + ++ +G+G++G V TG A+K + K+ +L+ ++H R Sbjct: 44 FERIRTLGTGSFGRVMLVKHKETGNHYAMK---------ILDKQKVVKLKQIEHTLNEKR 94 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 + + + + + D ++ Y+V+ + G L + + E +F Q++ Sbjct: 95 IQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLT 154 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-TRWYRAPEVILN 199 Y+H+ +I+RDLKP NL +++ +K+ DFG A++ + T Y APE+IL+ Sbjct: 155 FEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILS 214 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 Y + VD W++G ++ EM G F + ++I+ P+ F L+ Sbjct: 215 -KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLK 268 >3OMV-A nrPDB Length = 307 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 111/233 (47%), Gaps = 35/233 (15%) Query: 21 WEVRAVYRDLQP-VGSGAYGAVCSAVDGRTGAKVAIK--KLYRPFQSELFAKRAYRELRL 77 WE+ A L +GSG++G V G+ VA+K K+ P + A R E+ + Sbjct: 31 WEIEASEVMLSTRIGSGSFGTV---YKGKWHGDVAVKILKVVDPTPEQFQAFR--NEVAV 85 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF----- 132 L+ RH N++ + T D L + + L KH + E + Q Sbjct: 86 LRKTRHVNILLFMGYMTKDN---------LAIVTQWCEGSSLYKHLHVQETKFQMFQLID 136 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA--------RQADSEMTG 184 + Q +G+ Y+HA IIHRD+K N+ ++E +KI DFGLA Q + TG Sbjct: 137 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG 196 Query: 185 YVVTRWYRAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 V+ + APEVI + ++ D++S G ++ E++TG+ + ++ DQ+ Sbjct: 197 SVL---WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI 246 >5KKR-C nrPDB Length = 395 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 97/201 (48%), Gaps = 12/201 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + + +G+G G V +G +A K ++ + + + REL++L + Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYI 128 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYI 144 +G F D + + M M G L +++K ++ E + + ++KGL Y+ Sbjct: 129 VGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 182 Query: 145 HAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMR 202 I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y +PE L Sbjct: 183 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER-LQGTH 241 Query: 203 YTQTVDIWSVGCIMAEMITGK 223 Y+ DIWS+G + EM G+ Sbjct: 242 YSVQSDIWSMGLSLVEMAVGR 262 >4FZF-B nrPDB Length = 283 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 102/202 (50%), Gaps = 12/202 (5%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 ++ L+ +G G++G V +D RT VAIK + ++E + +E+ +L Sbjct: 9 LFTKLERIGKGSFGEVFKGIDNRTQQVVAIK-IIDLEEAEDEIEDIQQEITVLSQCDSSY 67 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYI 144 V + L +++M ++G L++ E +I ++ ++LKGL Y+ Sbjct: 68 VTKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYL 121 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEM--TGYVVTRWYRAPEVILNWM 201 H+ IHRD+K N+ ++E ++K+ FG+A Q D+++ +V T ++ APEVI Sbjct: 122 HSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-QQS 180 Query: 202 RYTQTVDIWSVGCIMAEMITGK 223 Y DIWS+G E+ G+ Sbjct: 181 AYDSKADIWSLGITAIELAKGE 202 >3EQC-A nrPDB Length = 360 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 97/201 (48%), Gaps = 12/201 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + + +G+G G V +G +A K ++ + + + REL++L + Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYI 93 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYI 144 +G F D + + M M G L +++K ++ E + + ++KGL Y+ Sbjct: 94 VGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 147 Query: 145 HAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMR 202 I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y +PE L Sbjct: 148 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPER-LQGTH 206 Query: 203 YTQTVDIWSVGCIMAEMITGK 223 Y+ DIWS+G + EM G+ Sbjct: 207 YSVQSDIWSMGLSLVEMAVGR 227 >2XIK-A nrPDB Length = 294 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 101/202 (50%), Gaps = 12/202 (5%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 ++ L +G G++G V +D T VAIK + ++E + +E+ +L Sbjct: 20 LFTKLDRIGKGSFGEVYKGIDNHTKEVVAIK-IIDLEEAEDEIEDIQQEITVLSQCDSPY 78 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + + T +++M ++G L+K L E I ++ ++LKGL Y+ Sbjct: 79 ITRYFGSYLKS------TKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYL 132 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEM--TGYVVTRWYRAPEVILNWM 201 H+ IHRD+K N+ ++E ++K+ DFG+A Q D+++ +V T ++ APEVI Sbjct: 133 HSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQS 191 Query: 202 RYTQTVDIWSVGCIMAEMITGK 223 Y DIWS+G E+ G+ Sbjct: 192 AYDFKADIWSLGITAIELAKGE 213 >3PPZ-A nrPDB Length = 309 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 15/197 (7%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA---YRELRLLKHMRHENVIGL 89 +G+G++G V A G+ VA+K L + + A+R RE+ ++K +RH N++ Sbjct: 45 IGAGSFGTVHRA--EWHGSDVAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG- 148 + T L T+ YL + L K E+L E R + Y + KG+ Y+H Sbjct: 100 MGAVTQPPNLSIVTE-YLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 149 -IIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYT 204 I+HRDLK NL V++ +K+ DFGL+R S T + APEV+ + Sbjct: 159 PIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRD-EPSN 217 Query: 205 QTVDIWSVGCIMAEMIT 221 + D++S G I+ E+ T Sbjct: 218 EKSDVYSFGVILWELAT 234 >3HMP-A nrPDB Length = 342 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 77/307 (25%), Positives = 131/307 (42%), Gaps = 58/307 (18%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRH- 83 +Y L+ +GSG V ++ + ++ K +++ +YR E+ L ++ Sbjct: 57 IYSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 114 Query: 84 -ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE--DRIQFLVYQMLKG 140 + +I L D D+ + Y+VM DL +K +K + +R + ML+ Sbjct: 115 SDKIIRLYDYEITDQYI------YMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEA 167 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-----TRWYRAPE 195 + IH GI+H DLKP N + D LK++DFG+A Q + T V T Y PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 196 VILNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 I + + D+WS+GCI+ M GKT F+ ++Q+ ++ + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQI--INQISKLHAIIDP- 283 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 N+ P++ +KD +L L D +QR++ E Sbjct: 284 --------------NHEIEFPDIPEKDLQDVLKCC-----------LKRDPKQRISIPEL 318 Query: 306 LAHPYFE 312 LAHPY + Sbjct: 319 LAHPYVQ 325 >4RA4-A nrPDB Length = 355 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 55/171 (32%), Positives = 85/171 (49%), Gaps = 21/171 (12%) Query: 105 FYLVMPFMGTDLGKLMKH----EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA 160 Y VM ++ G LM H K E + F ++ GL ++H GII+RDLK N+ Sbjct: 96 LYFVMEYVNG--GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVM 153 Query: 161 VNEDCELKILDFGLARQADSEMTGYVVTRW------YRAPEVILNWMRYTQTVDIWSVGC 214 ++ + +KI DFG+ ++ M V TR Y APE+I + Y ++VD W+ G Sbjct: 154 LDSEGHIKIADFGMCKE---HMMDGVTTRTFCGTPDYIAPEII-AYQPYGKSVDWWAYGV 209 Query: 215 IMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 ++ EM+ G+ F G D + + IM+ + P S EA + KGL Sbjct: 210 LLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSL-----SKEAVSICKGL 255 >3UIU-A nrPDB Length = 306 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/228 (29%), Positives = 113/228 (49%), Gaps = 46/228 (20%) Query: 27 YRDLQPVGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 +++++ +GSG +G V A +DG+T +K + +E +A RE++ L + H Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK-----YNNE----KAEREVKALAKLDH 64 Query: 84 ENVI---GLLDVFTPD-ETLDDFTD-------------------FYLVMPFMGTDLGKL- 119 N++ G D F D ET DD + ++ M F D G L Sbjct: 65 VNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEF--CDKGTLE 122 Query: 120 -----MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL 174 + EKL + L Q+ KG+ YIH+ +IHRDLKP N+ + + ++KI DFGL Sbjct: 123 QWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGL 182 Query: 175 --ARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI 220 + + D + T T Y +PE I + Y + VD++++G I+AE++ Sbjct: 183 VTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL 229 >4AN9-A nrPDB Length = 301 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 97/201 (48%), Gaps = 12/201 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + + +G+G G V +G +A K ++ + + + REL++L + Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSPYI 69 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYI 144 +G F D + + M M G L +++K ++ E + + ++KGL Y+ Sbjct: 70 VGFYGAFYSD------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL 123 Query: 145 HAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG-YVVTRWYRAPEVILNWMR 202 I+HRD+KP N+ VN E+K+ DFG++ Q EM +V TR Y +PE L Sbjct: 124 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPER-LQGTH 182 Query: 203 YTQTVDIWSVGCIMAEMITGK 223 Y+ DIWS+G + EM G+ Sbjct: 183 YSVQSDIWSMGLSLVEMAVGR 203 >3TXO-A nrPDB Length = 353 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 103/219 (47%), Gaps = 16/219 (7%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMR-HENVI 87 ++ +G G++G V A TG A+K L + + + E R+L R H + Sbjct: 28 IRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLT 87 Query: 88 GLLDVF-TPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYI 144 L F TPD + VM F+ G DL + K + E R +F +++ L ++ Sbjct: 88 QLFCCFQTPDR-------LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 140 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILNWM 201 H GII+RDLK N+ ++ + K+ DFG+ ++ + T Y APE IL M Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE-ILQEM 199 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Y VD W++G ++ EM+ G F+ + D + I+ Sbjct: 200 LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN 238 >6DBN-A nrPDB Length = 316 Score = 74.7 bits (182), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 110/223 (49%), Gaps = 26/223 (11%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAV--C--SAVDGRTGAKVAIKKLYRPFQSELFAKR 70 EV T +E R + R ++ +G G +G V C TG +VA+K L +P Sbjct: 26 EVDPTHFEKRFLKR-IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL-KPESGGNHIAD 83 Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRI 130 +E+ +L+++ HEN++ + T D L+M F+ + G L ++ +++I Sbjct: 84 LKKEIEILRNLYHENIVKYKGICTEDGG----NGIKLIMEFLPS--GSLKEYLPKNKNKI 137 Query: 131 ---QFLVY--QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY 185 Q L Y Q+ KG+ Y+ + +HRDL N+ V + ++KI DFGL + +++ Y Sbjct: 138 NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY 197 Query: 186 VVTR-------WYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 V WY APE ++ Y + D+WS G + E++T Sbjct: 198 TVKDDRDSPVFWY-APECLMQSKFYIAS-DVWSFGVTLHELLT 238 >2W4O-A nrPDB Length = 349 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 71/245 (28%), Positives = 109/245 (44%), Gaps = 42/245 (17%) Query: 74 ELRLLKHMRHENVIGLLDVF-TPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRI 130 E+ +L + H N+I L ++F TP T+ LV+ + G ++++ E Sbjct: 98 EIGVLLRLSHPNIIKLKEIFETP-------TEISLVLELVTGGELFDRIVEKGYYSERDA 150 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGY 185 V Q+L+ + Y+H GI+HRDLKP NL D LKI DFGL++ + + M Sbjct: 151 ADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTV 210 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 T Y APE IL Y VD+WSVG I ++ G F + DQ Sbjct: 211 CGTPGYCAPE-ILRGCAYGPEVDMWSVGIITYILLCGFEPFY-DERGDQF---------- 258 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 + + E + S A +L+ K++VLD ++R+T +A Sbjct: 259 ---------------MFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQA 303 Query: 306 LAHPY 310 L HP+ Sbjct: 304 LQHPW 308 >3DKO-A nrPDB Length = 318 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 99/208 (47%), Gaps = 34/208 (16%) Query: 33 VGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G+G +G VCS + G+ VAIK L + +E + E ++ H NV+ L Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY-TEKQRRDFLCEASIMGQFDHPNVVHL 109 Query: 90 LDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQML-------KG 140 V T + + +V+ FM G L KH+ QF V Q++ G Sbjct: 110 EGVVTRGKPV------MIVIEFMENGALDAFLRKHDG------QFTVIQLVGMLRGIAAG 157 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR--QADSEMT-----GYVVTRWYRA 193 +RY+ G +HRDL N+ VN + K+ DFGL+R + D E G + RW A Sbjct: 158 MRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW-TA 216 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT 221 PE I + ++T D+WS G +M E+++ Sbjct: 217 PEAI-QYRKFTSASDVWSYGIVMWEVMS 243 >2HK5-A nrPDB Length = 270 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 116/229 (50%), Gaps = 18/229 (7%) Query: 18 KTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 K AWE+ R + + +G+G +G V A + KVA+K + +P + A A E Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTM-KPGSMSVEAFLA--EAN 62 Query: 77 LLKHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLV 134 ++K ++H+ ++ L V T P + +F ++ F+ +D G KL I F Sbjct: 63 VMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKL----IDFSA 118 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW--- 190 Q+ +G+ +I IHRDL+ N+ V+ KI DFGLAR D+E T ++ Sbjct: 119 -QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIK 177 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 + APE I N+ +T D+WS G ++ E++T G+ + G + + ++ + Sbjct: 178 WTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL 225 >5AP3-A nrPDB Length = 313 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 77/307 (25%), Positives = 131/307 (42%), Gaps = 58/307 (18%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRH- 83 +Y L+ +GSG V ++ + ++ K +++ +YR E+ L ++ Sbjct: 29 IYSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 86 Query: 84 -ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE--DRIQFLVYQMLKG 140 + +I L D D+ + Y+VM DL +K +K + +R + ML+ Sbjct: 87 SDKIIRLYDYEITDQYI------YMVMECGNIDLNGWLKKKKSIDPWERKSYW-KNMLEA 139 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-----TRWYRAPE 195 + IH GI+H DLKP N + D LK++DFG+A Q + T V T Y PE Sbjct: 140 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 198 Query: 196 VILNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 I + + D+WS+GCI+ M GKT F+ ++Q+ ++ + Sbjct: 199 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQI--INQISKLHAIIDP- 255 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 N+ P++ +KD +L L D +QR++ E Sbjct: 256 --------------NHEIEFPDIPEKDLQDVLKCC-----------LKRDPKQRISIPEL 290 Query: 306 LAHPYFE 312 LAHPY + Sbjct: 291 LAHPYVQ 297 >4E93-A nrPDB Length = 377 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 92/198 (46%), Gaps = 18/198 (9%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G +G V S VA+K +L AK +E R+LK H N++ L+ V Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGV 180 Query: 93 FTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQFLVYQMLKGLRYIHAAGI 149 T + + Y+VM + G D ++ E +L + +V G+ Y+ + Sbjct: 181 CTQKQPI------YIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 234 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQ------ADSEMTGYVVTRWYRAPEVILNWMRY 203 IHRDL N V E LKI DFG++R+ A S V +W APE LN+ RY Sbjct: 235 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPEA-LNYGRY 292 Query: 204 TQTVDIWSVGCIMAEMIT 221 + D+WS G ++ E + Sbjct: 293 SSESDVWSFGILLWETFS 310 >3LLT-A nrPDB Length = 360 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 92/223 (41%), Gaps = 41/223 (18%) Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE-------------------------D 164 I+ ++LK L Y+ + H DLKP N+ +++ Sbjct: 139 IKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKS 198 Query: 165 CELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT 224 +K++DFG A + TR YRAPEVILN + + + D+WS GC++AE+ TG Sbjct: 199 TGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTGSL 257 Query: 225 LFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM-KGLPELEKKDFASILTNAS-- 281 LF+ +H++ L + + P + Y+ K +L + AS + + Sbjct: 258 LFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHV 317 Query: 282 ------------PLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 L + L +L +D R + E L H + E Sbjct: 318 KKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >5DBX-A nrPDB Length = 328 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 101/223 (45%), Gaps = 26/223 (11%) Query: 19 TAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 W + R Y + +GSGA V +A+ +VAIK++ + + +E++ Sbjct: 4 VGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLE-KCQTSMDELLKEIQA 62 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLM------KHEKLGE 127 + H NV+ F + L +LVM + D+ K + K+ L E Sbjct: 63 MSQCSHPNVVTYYTSFVVKDEL------WLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEE 116 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG----LARQADSEMT 183 I ++ ++L+GL Y+H G IHRDLK GN+ + ED ++I DFG LA D Sbjct: 117 AIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRN 176 Query: 184 G----YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 +V T + APEV+ Y D+WS G E+ TG Sbjct: 177 KVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATG 219 >2ZMD-A nrPDB Length = 390 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 77/307 (25%), Positives = 130/307 (42%), Gaps = 58/307 (18%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRH- 83 +Y L+ +GSG V ++ + ++ K +++ +YR E+ L ++ Sbjct: 57 IYSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQH 114 Query: 84 -ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE--DRIQFLVYQMLKG 140 + +I L D D+ + Y+VM DL +K +K + +R + ML+ Sbjct: 115 SDKIIRLYDYEITDQYI------YMVMECGNIDLNSWLKKKKSIDPWERKSYW-KNMLEA 167 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW-----YRAPE 195 + IH GI+H DLKP N + D LK++DFG+A Q + T V Y PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 196 VILNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 I + + D+WS+GCI+ M GKT F ++I+ Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---------QQIINQ---- 273 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 + +L + N+ P++ +KD +L L D +QR++ E Sbjct: 274 ----ISKLHAIIDPNHEIEFPDIPEKDLQDVLKCC-----------LKRDPKQRISIPEL 318 Query: 306 LAHPYFE 312 LAHPY + Sbjct: 319 LAHPYVQ 325 >3VN9-A nrPDB Length = 340 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 85/339 (25%), Positives = 146/339 (43%), Gaps = 67/339 (19%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPV---GSGAYGAVCSAVDGRTGAKVAIKKL 58 S+PP + +EV+A DL+P+ G GAYG V +G +A+K++ Sbjct: 27 STPPRDLDSKACISIGNQNFEVKA--DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI 84 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGK 118 S+ KR +L + MR + + + L D ++ M M T L K Sbjct: 85 RATVNSQE-QKRLLMDLDI--SMRTVDCPFTVTFYG---ALFREGDVWICMELMDTSLDK 138 Query: 119 LMKH-----EKLGEDRIQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVNEDCELKILDF 172 K + + ED + + ++K L ++H+ +IHRD+KP N+ +N ++K+ DF Sbjct: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 Query: 173 GLARQADSEMTGYVV----------TRWYRAPEVI---LNWMRYTQTVDIWSVGCIMAEM 219 G+ +GY+V + Y APE I LN Y+ DIWS+G M E+ Sbjct: 199 GI--------SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 Query: 220 ITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTN 279 L+ GTP + Q ++ P+L F++ Sbjct: 251 AI-------------LRFPYDSWGTPFQQLKQVVEEPS--------PQLPADKFSAEF-- 287 Query: 280 ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 V+ + L ++++R T E + HP+F +LH+++ Sbjct: 288 -----VDFTSQCLKKNSKERPTYPELMQHPFF-TLHESK 320 >2A1A-B nrPDB Length = 284 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 113/215 (52%), Gaps = 33/215 (15%) Query: 27 YRDLQPVGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 +++++ +GSG +G V A +DG+T IK++ + +E +A RE++ L + H Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKT---YVIKRV--KYNNE----KAEREVKALAKLDH 63 Query: 84 ENVI---GLLDVFTPD-ETLDDFTD------FYLVMPFMGTDLGKL------MKHEKLGE 127 N++ G D F D ET + ++ M F D G L + EKL + Sbjct: 64 VNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEF--CDKGTLEQWIEKRRGEKLDK 121 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL--ARQADSEMTGY 185 L Q+ KG+ YIH+ +I+RDLKP N+ + + ++KI DFGL + + D + T Sbjct: 122 VLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRS 181 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI 220 T Y +PE I + Y + VD++++G I+AE++ Sbjct: 182 KGTLRYMSPEQISS-QDYGKEVDLYALGLILAELL 215 >1BYG-A nrPDB Length = 278 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 104/228 (45%), Gaps = 26/228 (11%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 M A+ FYR E++ LQ +G G +G V + G KVA+K + Sbjct: 1 MGGSVAAQDEFYRSGWALNMKELKL----LQTIGKGEFGDV--MLGDYRGNKVAVKCIKN 54 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 ++ F A ++ +RH N++ LL V ++ Y+V +M G L+ Sbjct: 55 DATAQAFLAEA----SVMTQLRHSNLVQLLGVIVEEKG-----GLYIVTEYMAK--GSLV 103 Query: 121 KHEK------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL 174 + + LG D + + + + Y+ +HRDL N+ V+ED K+ DFGL Sbjct: 104 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL 163 Query: 175 ARQADSEM-TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 ++A S TG + +W APE L +++ D+WS G ++ E+ + Sbjct: 164 TKEASSTQDTGKLPVKW-TAPEA-LREKKFSTKSDVWSFGILLWEIYS 209 >5HIE-A nrPDB Length = 302 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 109/220 (49%), Gaps = 35/220 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 Q +GSG++G V G+ VA+K L P Q + F E+ +L+ RH N++ + Sbjct: 42 QRIGSGSFGTV---YKGKWHGDVAVKML-TPQQLQAFKN----EVGVLRKTRHVNILLFM 93 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL-----VYQMLKGLRYIH 145 T + L + + L H + E + + + Q +G+ Y+H Sbjct: 94 GYSTKPQ---------LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLH 144 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLA----RQADS----EMTGYVVTRWYRAPEVI 197 A IIHRDLK N+ ++ED +KI DFGLA R + S +++G ++ + APEVI Sbjct: 145 AKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSIL---WMAPEVI 201 Query: 198 LNWMR--YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 + Y+ D+++ G ++ E++TG+ + ++ DQ+ Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 241 >5TUR-A nrPDB Length = 404 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 21/208 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAYRELRLLKHMRH--ENV 86 +GSG +G+V S + VAIK + + S+ R E+ LLK + V Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYIH 145 I LLD F E D F L P DL + L E+ + +Q+L+ +R+ H Sbjct: 195 IRLLDWF---ERPDSFV-LILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 250 Query: 146 AAGIIHRDLKPGNLAVNED-CELKILDFGL-ARQADSEMTGYVVTRWYRAPEVILNWMRY 203 G++HRD+K N+ ++ + ELK++DFG A D+ T + TR Y PE W+RY Sbjct: 251 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE----WIRY 306 Query: 204 ----TQTVDIWSVGCIMAEMITGKTLFK 227 ++ +WS+G ++ +M+ G F+ Sbjct: 307 HRYHGRSAAVWSLGILLYDMVCGDIPFE 334 >5X5O-A nrPDB Length = 310 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 109/251 (43%), Gaps = 38/251 (15%) Query: 23 VRAVYRDLQ---PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 V+ + DLQ G G++G+V A +VA+KKL + +E +L Sbjct: 10 VQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILS 59 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM------KHEKLGEDRIQFL 133 + H N+I V T++ LG L + E++ D I Sbjct: 60 VLSHRNIIQFYGVILEPPNYGIVTEY--------ASLGSLYDYINSNRSEEMDMDHIMTW 111 Query: 134 VYQMLKGLRYIHAAG---IIHRDLKPGNLAVNEDCELKILDFGLAR-QADSEMTGYVVTR 189 + KG+ Y+H +IHRDLK N+ + D LKI DFG +R + V T Sbjct: 112 ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTF 171 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD------QLKEIMKVTG 243 + APEVI + + ++T D +S G ++ EM+T + FKG + L + E + + Sbjct: 172 PWMAPEVIQS-LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPS 230 Query: 244 TPPAEFVQRLQ 254 + P F + L Sbjct: 231 SCPRSFAELLH 241 >4M7I-A nrPDB Length = 299 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/283 (23%), Positives = 125/283 (44%), Gaps = 37/283 (13%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +Q +G G +G V A + AIK++ P EL ++ RE++ L + H + Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGI 65 Query: 87 IGLLDVFTPDETLDDFTD------FYLVMPFM-GTDLGKLMKHEKLGEDR----IQFLVY 135 + + + T + Y+ M +L M E+R + Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------------- 181 Q+ + + ++H+ G++HRDLKP N+ D +K+ DFGL D + Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 185 Query: 182 -MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 TG V T+ Y +PE I + Y+ VDI+S+G I+ E+ L+ S +++++ + Sbjct: 186 RHTGQVGTKLYMSPEQI-HGNSYSHKVDIFSLGLILFEL-----LYPFSTQMERVRTLTD 239 Query: 241 VTGTP-PAEFVQRLQSD--EAKNYMKGLPELEKKDFASILTNA 280 V P F Q+ + ++ + P +E+ + +I+ NA Sbjct: 240 VRNLKFPPLFTQKYPCEYVMVQDMLSPSP-MERPEAINIIENA 281 >5UIU-A nrPDB Length = 323 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/227 (29%), Positives = 106/227 (46%), Gaps = 28/227 (12%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR--PFQSELFA 68 FY + ++ R + +G G +G V T VA+KKL +E Sbjct: 33 FYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELK 90 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 ++ +E++++ +HEN++ LL F+ D DD Y+ MP G+ L +L D Sbjct: 91 QQFDQEIKVMAKCQHENLVELLG-FSSDG--DDLCLVYVYMP-NGSLLDRLS-----CLD 141 Query: 129 RIQFLVYQM--------LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--- 177 L + M G+ ++H IHRD+K N+ ++E KI DFGLAR Sbjct: 142 GTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEK 201 Query: 178 -ADSEMTGYVV-TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 A + MT +V T Y APE + + T DI+S G ++ E+ITG Sbjct: 202 FAQTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITG 246 >5UUU-A nrPDB Length = 547 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/241 (26%), Positives = 113/241 (46%), Gaps = 17/241 (7%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK----KLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V TG A+K K + Q E A L L+ ++ Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 265 Query: 89 LLDVF-TPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 + F TPD+ ++ M G DL L +H E ++F +++ GL ++H Sbjct: 266 MSYAFHTPDK-------LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 318 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMRYT 204 +++RDLKP N+ ++E ++I D GLA + + V T Y APEV+ + Y Sbjct: 319 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 378 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 + D +S+GC++ +++ G + F+ D+ EI ++T T E S E ++ ++G Sbjct: 379 SSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF-SPELRSLLEG 436 Query: 265 L 265 L Sbjct: 437 L 437 >1K9A-A nrPDB Length = 450 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 105/228 (46%), Gaps = 26/228 (11%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 M A+ FYR E++ LQ +G G +G V + G KVA+K + Sbjct: 173 MEGTVAAQDEFYRSGWALNMKELKL----LQTIGKGEFGDV--MLGDYRGNKVAVKCIKN 226 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 ++ F A ++ +RH N++ LL V +++ Y+V +M G L+ Sbjct: 227 DATAQAFLAEA----SVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAK--GSLV 275 Query: 121 KHEK------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL 174 + + LG D + + + + Y+ +HRDL N+ V+ED K+ DFGL Sbjct: 276 DYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGL 335 Query: 175 ARQADSEM-TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 ++A S TG + +W APE L +++ D+WS G ++ E+ + Sbjct: 336 TKEASSTQDTGKLPVKW-TAPEA-LREKKFSTKSDVWSFGILLWEIYS 381 >1VZO-A nrPDB Length = 355 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/303 (23%), Positives = 142/303 (46%), Gaps = 49/303 (16%) Query: 30 LQPVGSGAYGAV--CSAVDGR-TGAKVAIKKLYRP--FQSELFAKRAYRELRLLKHMRHE 84 L+ +G+GAYG V + G TG A+K L + Q + E ++L+H+R Sbjct: 59 LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQS 118 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 + L ET +L++ ++ G L + E+ E +Q V +++ L Sbjct: 119 PFLVTLHYAFQTET-----KLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 173 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT----GYVVTRWYRAPEVIL 198 ++H GII+RD+K N+ ++ + + + DFGL+++ ++ T + T Y AP+++ Sbjct: 174 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPDIVR 233 Query: 199 NW-MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 + + VD WS+G +M E++TG + F V G + Q++ Sbjct: 234 GGDSGHDKAVDWWSLGVLMYELLTGASPF-------------TVDGEKNS------QAEI 274 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG-----EALAHPYFE 312 ++ +K P ++ S LA +L++++L+ D ++R+ G E H +F+ Sbjct: 275 SRRILKSEPPYPQE--------MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 Query: 313 SLH 315 ++ Sbjct: 327 KIN 329 >1JPA-A nrPDB Length = 312 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 99/206 (48%), Gaps = 24/206 (11%) Query: 31 QPVGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 Q +G+G +G VCS + G+ VAIK L + +E + E ++ H NVI Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQRRDFLSEASIMGQFDHPNVI 97 Query: 88 ---GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 G++ TP + +F + + F+ + G+ + +G ++ + G++Y+ Sbjct: 98 HLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVG------MLRGIAAGMKYL 151 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---------SEMTGYVVTRWYRAPE 195 +HRDL N+ VN + K+ DFGL+R + S + G + RW APE Sbjct: 152 ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAPE 210 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT 221 I + ++T D+WS G +M E+++ Sbjct: 211 AI-QYRKFTSASDVWSYGIVMWEVMS 235 >1AD5-A nrPDB Length = 438 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 111/227 (48%), Gaps = 20/227 (8%) Query: 6 PARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQS 64 P S ++ K AWE+ R + + +G+G +G V A + KVA+K + +P Sbjct: 162 PCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTM-KPGSM 219 Query: 65 ELFAKRAYRELRLLKHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKH 122 + A A E ++K ++H+ ++ L V T P + +F ++ F+ +D G Sbjct: 220 SVEAFLA--EANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPL 277 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM 182 KL I F Q+ +G+ +I IHRDL+ N+ V+ KI DFGLAR + Sbjct: 278 PKL----IDFSA-QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-----V 327 Query: 183 TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +W APE I N+ +T D+WS G ++ E++T G+ + G Sbjct: 328 GAKFPIKW-TAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 372 >2VWV-A nrPDB Length = 302 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 25/224 (11%) Query: 14 QEVTKTAWEVRAVYRDLQPV-GSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAK 69 + V + A E+ Y ++ V G+G +G VC G+ + VAIK L + +E + Sbjct: 4 EAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGY-TERQRR 62 Query: 70 RAYRELRLLKHMRHENVIGLLDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126 E ++ H N+I L V T P L +F + + F+ + G+ + +G Sbjct: 63 EFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVG 122 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR---------Q 177 ++ + G+RY+ +HRDL N+ VN + K+ DFGL+R Sbjct: 123 ------MLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPT 176 Query: 178 ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 S + G + RW APE I + ++T D WS G +M E+++ Sbjct: 177 ETSSLGGKIPIRWT-APEAIA-FRKFTSASDAWSYGIVMWEVMS 218 >6BXI-A nrPDB Length = 333 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 114/265 (43%), Gaps = 50/265 (18%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE-N 85 + L+ +G GA+G V TG A+K L + +++ K +R + + E + Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRK---ADMLEKEQVGHIRAERDILVEAD 64 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + ++ +F + D + YL+M F+ G + LMK + L E+ QF + + + + Sbjct: 65 SLWVVKMFY---SFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLA---------------------------- 175 IH G IHRD+KP NL ++ +K+ DFGL Sbjct: 122 IHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNM 181 Query: 176 ---RQADSEMTG-------YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL 225 R+A++ V T Y APEV + Y + D WS+G IM EM+ G Sbjct: 182 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQ-TGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 226 FKGSDHLDQLKEIM--KVTGTPPAE 248 F + K++M K T T P E Sbjct: 241 FCSETPQETYKKVMNWKETLTFPPE 265 >3ORP-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 112/245 (45%), Gaps = 18/245 (7%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRHENVIGLLD 91 +G G V A D R VA+K L + F R RE + + H ++ + D Sbjct: 20 LGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYD 79 Query: 92 VF---TPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYIHA 146 TP L Y+VM ++ G L ++ E + R ++ + L + H Sbjct: 80 TGEAETPAGPLP-----YIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQ 134 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADS-----EMTGYVVTRWYRAPEVILNW 200 GIIHRD+KP N+ ++ +K++DFG+AR ADS + + T Y +PE Sbjct: 135 NGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGD 194 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 ++ D++S+GC++ E++TG+ F G + + ++ PP+ + L +D Sbjct: 195 SVDARS-DVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAV 253 Query: 261 YMKGL 265 +K L Sbjct: 254 VLKAL 258 >3PVW-A nrPDB Length = 695 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/241 (26%), Positives = 113/241 (46%), Gaps = 17/241 (7%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK----KLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V TG A+K K + Q E A L L+ ++ Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVC 256 Query: 89 LLDVF-TPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 + F TPD+ ++ M G DL L +H E ++F +++ GL ++H Sbjct: 257 MSYAFHTPDK-------LSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH 309 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWMRYT 204 +++RDLKP N+ ++E ++I D GLA + + V T Y APEV+ + Y Sbjct: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 + D +S+GC++ +++ G + F+ D+ EI ++T T E S E ++ ++G Sbjct: 370 SSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF-SPELRSLLEG 427 Query: 265 L 265 L Sbjct: 428 L 428 >5EG3-A nrPDB Length = 334 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 60/224 (26%), Positives = 105/224 (46%), Gaps = 43/224 (19%) Query: 31 QPVGSGAYGAVCSA----VDG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 +P+G GA+G V A +D + VA+K L + +E E+ ++K + + Sbjct: 41 KPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLVSEMEMMKMIGK 99 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPF-------------------MGTDLGKLMKHE 123 H+N+I LL T D L Y+++ + + D+ ++ + + Sbjct: 100 HKNIINLLGACTQDGPL------YVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS--- 180 +D + YQ+ +G+ Y+ + IHRDL N+ V E+ +KI DFGLAR ++ Sbjct: 154 MTFKDLVS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDF 212 Query: 181 ---EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 G + +W APE + + + YT D+WS G +M E+ T Sbjct: 213 FKETTNGRLPVKWM-APEALFDRV-YTHQSDVWSFGVLMWEIFT 254 >4PL5-B nrPDB Length = 435 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 92/322 (28%), Positives = 142/322 (44%), Gaps = 66/322 (20%) Query: 33 VGSGAYGAVC--SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGL 89 +G GA G + D R VA+K++ E F+ A RE++LL+ H NVI Sbjct: 35 LGHGAEGTIVYKGMFDNR---DVAVKRIL----PECFS-FADREVQLLRESDEHPNVIRY 86 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE---KLGEDRIQFLVYQMLKGLRYIHA 146 T D Y+ + L + ++ + LG + I L++Q GL ++H+ Sbjct: 87 FC------TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPIT-LLHQTTSGLAHLHS 139 Query: 147 AGIIHRDLKPGNLAV---NEDCELK--ILDFGLA------RQADSEMTGYVVTRWYRAPE 195 I+HRDLKP N+ + N +K I DFGL R + S +G T + APE Sbjct: 140 LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 199 Query: 196 VILNWMR--YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 ++ + T TVDI+S GC+ +I+ G P F + L Sbjct: 200 MLSEDCKDNPTYTVDIFSAGCVFYYVIS--------------------EGYHP--FGKSL 237 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Q N + G L D + +A L+EKM+ +D +QR +A L HP+F S Sbjct: 238 Q--RQANILLGACNL---DCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWS 292 Query: 314 LHDTEDEPQVQKYDDSFDDVDR 335 L E Q+Q + D D +++ Sbjct: 293 L-----EKQLQFFQDVSDRIEK 309 >4RC3-A nrPDB Length = 289 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 21/208 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAYRELRLLKHMRH--ENV 86 +GSG +G+V S + VAIK + + S+ R E+ LLK + V Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYIH 145 I LLD F E D F L P DL + L E+ + +Q+L+ +R+ H Sbjct: 80 IRLLDWF---ERPDSFV-LILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 135 Query: 146 AAGIIHRDLKPGNLAVNED-CELKILDFGL-ARQADSEMTGYVVTRWYRAPEVILNWMRY 203 G++HRD+K N+ ++ + ELK++DFG A D+ T + TR Y PE W+RY Sbjct: 136 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE----WIRY 191 Query: 204 ----TQTVDIWSVGCIMAEMITGKTLFK 227 ++ +WS+G ++ +M+ G F+ Sbjct: 192 HRYHGRSAAVWSLGILLYDMVCGDIPFE 219 >4WUA-A nrPDB Length = 401 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 90/365 (24%), Positives = 147/365 (40%), Gaps = 84/365 (23%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH--- 83 Y ++ +G G + V + D + VA+K + +E + + A E+RLLK +R+ Sbjct: 43 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSDP 99 Query: 84 -----ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM---KHEKLGEDRIQFLVY 135 E V+ LLD F + T +V +G L K + ++ L ++ ++ Sbjct: 100 NDPNREMVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQ 157 Query: 136 QMLKGLRYIHA-AGIIHRDLKP-------------------------------------- 156 Q+L+GL Y+H IIH D+KP Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTA 217 Query: 157 ----GNLAVN-------EDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ 205 GN VN E ++KI D G A T + TR YR+ EV++ Y Sbjct: 218 PATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIG-SGYNT 276 Query: 206 TVDIWSVGCIMAEMITGKTLFK---GSDHL---DQLKEIMKVTGTPPAEFVQRLQSDE-- 257 DIWS C+ E+ TG LF+ G ++ D + I+++ G P + + + + Sbjct: 277 PADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEF 336 Query: 258 --AKNYMKGLPELEKKDFASILTNASPLA-------VNLLEKMLVLDAEQRVTAGEALAH 308 K +K + +L+ +L + + L ML L E+R TA E L H Sbjct: 337 FTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRH 396 Query: 309 PYFES 313 P+ S Sbjct: 397 PWLNS 401 >3BGP-A nrPDB Length = 333 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 21/208 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAYRELRLLKHMRH--ENV 86 +GSG +G+V S + VAIK + + S+ R E+ LLK + V Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYIH 145 I LLD F E D F L P DL + L E+ + +Q+L+ +R+ H Sbjct: 124 IRLLDWF---ERPDSFV-LILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 179 Query: 146 AAGIIHRDLKPGNLAVNED-CELKILDFGL-ARQADSEMTGYVVTRWYRAPEVILNWMRY 203 G++HRD+K N+ ++ + ELK++DFG A D+ T + TR Y PE W+RY Sbjct: 180 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE----WIRY 235 Query: 204 ----TQTVDIWSVGCIMAEMITGKTLFK 227 ++ +WS+G ++ +M+ G F+ Sbjct: 236 HRYHGRSAAVWSLGILLYDMVCGDIPFE 263 >6HV0-A nrPDB Length = 416 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 91/322 (28%), Positives = 143/322 (44%), Gaps = 66/322 (20%) Query: 33 VGSGAYGAVC--SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGL 89 +G GA G + D R VA+K++ E F+ A RE++LL+ H NVI Sbjct: 16 LGHGAEGTIVYRGMFDNR---DVAVKRIL----PECFS-FADREVQLLRESDEHPNVIRY 67 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE---KLGEDRIQFLVYQMLKGLRYIHA 146 T D Y+ + L + ++ + LG + I L+ Q GL ++H+ Sbjct: 68 FC------TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPIT-LLQQTTSGLAHLHS 120 Query: 147 AGIIHRDLKPGNLAV---NEDCELK--ILDFGLA------RQADSEMTGYVVTRWYRAPE 195 I+HRDLKP N+ + N ++K I DFGL R + S +G T + APE Sbjct: 121 LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 180 Query: 196 VILNWMRY--TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 ++ + T TVDI+S GC+ +I+ G+ P F + L Sbjct: 181 MLSEDCKENPTYTVDIFSAGCVFYYVIS--------------------EGSHP--FGKSL 218 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Q N + G L D + +A L+EKM+ +D ++R +A L HP+F S Sbjct: 219 Q--RQANILLGACSL---DCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWS 273 Query: 314 LHDTEDEPQVQKYDDSFDDVDR 335 L E Q+Q + D D +++ Sbjct: 274 L-----EKQLQFFQDVSDRIEK 290 >5HVK-A nrPDB Length = 315 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 25/206 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHENVIGLLD 91 +G G +G TG + +K+L R F E +R + +E+++++ + H NV+ + Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIR-FDEE--TQRTFLKEVKVMRCLEHPNVLKFIG 78 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIH 151 V D+ L+ T++ G + K M + R+ F + G+ Y+H+ IIH Sbjct: 79 VLYKDKRLNFITEYIKGGTLRG--IIKSMDSQYPWSQRVSF-AKDIASGMAYLHSMNIIH 135 Query: 152 RDLKPGNLAVNEDCELKILDFGLARQADSEMT-----------------GYVVTRWYRAP 194 R+L N V E+ + + DFGLAR E T V ++ AP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMI 220 E+I N Y + VD++S G ++ E+I Sbjct: 196 EMI-NGRSYDEKVDVFSFGIVLCEII 220 >3FME-A nrPDB Length = 290 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 81/321 (25%), Positives = 141/321 (43%), Gaps = 67/321 (20%) Query: 20 AWEVRAVYRDLQPV---GSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 + EV+A DL+P+ G GAYG V +G +A+K++ S+ KR +L Sbjct: 1 SMEVKA--DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE-QKRLLMDLD 57 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQ 131 + MR + + + L D ++ M M T L K K + + ED + Sbjct: 58 I--SMRTVDCPFTVTFYG---ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 112 Query: 132 FLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV--- 187 + ++K L ++H+ +IHRD+KP N+ +N ++K+ DFG+ +GY+V Sbjct: 113 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--------SGYLVDDV 164 Query: 188 -------TRWYRAPEVI---LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 + Y APE I LN Y+ DIWS+G M E+ + + Sbjct: 165 AKDIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS--------- 215 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 GTP + Q ++ P+L F++ V+ + L +++ Sbjct: 216 ----WGTPFQQLKQVVEEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSK 256 Query: 298 QRVTAGEALAHPYFESLHDTE 318 +R T E + HP+F +LH+++ Sbjct: 257 ERPTYPELMQHPFF-TLHESK 276 >2PSQ-A nrPDB Length = 370 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 108/226 (47%), Gaps = 32/226 (14%) Query: 31 QPVGSGAYGAVCSA----VDG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 +P+G G +G V A +D + VA+K L + +E E+ ++K + + Sbjct: 87 KPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDLVSEMEMMKMIGK 145 Query: 83 HENVIGLLDVFTPDETLDDFTDF--------YLVM---PFM--GTDLGKLMKHEKLGEDR 129 H+N+I LL T D L ++ YL P M D+ ++ + + +D Sbjct: 146 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDL 205 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS------EMT 183 + YQ+ +G+ Y+ + IHRDL N+ V E+ +KI DFGLAR ++ Sbjct: 206 VS-CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 264 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 G + +W APE + + + YT D+WS G +M E+ T G + + G Sbjct: 265 GRLPVKWM-APEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPG 308 >3PFQ-A nrPDB Length = 674 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 53/167 (31%), Positives = 87/167 (52%), Gaps = 15/167 (8%) Query: 106 YLVMPFMGTDLGKLMKH-EKLG---EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 Y VM ++ G LM H +++G E F ++ GL ++ + GII+RDLK N+ + Sbjct: 418 YFVMEYVNG--GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 475 Query: 162 NEDCELKILDFGLARQA--DSEMT-GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 + + +KI DFG+ ++ D T + T Y APE+I + Y ++VD W+ G ++ E Sbjct: 476 DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYE 534 Query: 219 MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 M+ G+ F+G D + + IM+ P + S EA KGL Sbjct: 535 MLAGQAPFEGEDEDELFQSIMEHNVAYP-----KSMSKEAVAICKGL 576 >4IDT-A nrPDB Length = 356 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 114/250 (45%), Gaps = 35/250 (14%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 YR+EV ++R +G G++G V D +TG + A+KK+ + E+F RA Sbjct: 69 YREEVHWATHQLR--------LGRGSFGEVHRMEDKQTGFQCAVKKV----RLEVF--RA 114 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRI 130 EL + ++ L ++ F + G LG+L+K + L EDR Sbjct: 115 -EELMACAGLTSPRIVPLYGAVREGPWVNIFMEL-----LEGGSLGQLVKEQGCLPEDRA 168 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED-CELKILDFG--LARQADS----EMT 183 + + Q L+GL Y+H+ I+H D+K N+ ++ D + DFG + Q D +T Sbjct: 169 LYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLT 228 Query: 184 GYVV--TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG----KTLFKGSDHLDQLKE 237 G + T + APEV+L VD+WS C+M M+ G F+G L E Sbjct: 229 GDYIPGTETHMAPEVVLG-RSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASE 287 Query: 238 IMKVTGTPPA 247 V PP+ Sbjct: 288 PPPVREIPPS 297 >2I0E-A nrPDB Length = 353 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 53/167 (31%), Positives = 87/167 (52%), Gaps = 15/167 (8%) Query: 106 YLVMPFMGTDLGKLMKH-EKLG---EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 Y VM ++ G LM H +++G E F ++ GL ++ + GII+RDLK N+ + Sbjct: 97 YFVMEYVNG--GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 154 Query: 162 NEDCELKILDFGLARQA--DSEMT-GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 + + +KI DFG+ ++ D T + T Y APE+I + Y ++VD W+ G ++ E Sbjct: 155 DSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYE 213 Query: 219 MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 M+ G+ F+G D + + IM+ P + S EA KGL Sbjct: 214 MLAGQAPFEGEDEDELFQSIMEHNVAYP-----KSMSKEAVAICKGL 255 >5L6P-A nrPDB Length = 298 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 95/204 (46%), Gaps = 24/204 (11%) Query: 33 VGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G+G +G VC GR VAIK L + +E + E ++ H N+I L Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQRRDFLSEASIMGQFDHPNIIRL 85 Query: 90 LDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 V T P L +F + + F+ + G+ + +G ++ + G++Y+ Sbjct: 86 EGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVG------MLRGIAAGMKYLSE 139 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---------SEMTGYVVTRWYRAPEVI 197 +HRDL N+ VN + K+ DFGL+R + S + G + RW APE I Sbjct: 140 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-TAPEAI 198 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT 221 + ++T D+WS G +M E+++ Sbjct: 199 A-YRKFTSASDVWSYGIVMWEVMS 221 >1TKI-A nrPDB Length = 321 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 69/294 (23%), Positives = 135/294 (45%), Gaps = 46/294 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y + +G G +G V V+ + K + ++ K+ E+ +L RH N+ Sbjct: 7 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIARHRNI 63 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQFLVYQMLKGLRY 143 + L E+ + + ++ F+ G D+ + + +L E I V+Q+ + L++ Sbjct: 64 LHL------HESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQF 117 Query: 144 IHAAGIIHRDLKPGNL--AVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVIL 198 +H+ I H D++P N+ +KI++FG ARQ D+ + +Y APEV Sbjct: 118 LHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYY-APEVHQ 176 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + + T T D+WS+G ++ +++G F + ++ IM AE+ Sbjct: 177 HDVVSTAT-DMWSLGTLVYVLLSGINPFLAETNQQIIENIMN------AEYT-------- 221 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 +++ F I S A++ ++++LV + + R+TA EAL HP+ + Sbjct: 222 ---------FDEEAFKEI----SIEAMDFVDRLLVKERKSRMTASEALQHPWLK 262 >3A8W-A nrPDB Length = 345 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/164 (31%), Positives = 84/164 (51%), Gaps = 15/164 (9%) Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEKLGEDRIQFLVYQMLKG 140 H ++GL F + L F+++ G DL + + KL E+ +F ++ Sbjct: 68 NHPFLVGLHSCFQTESRL-----FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLA 122 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA----RQADSEMTGYVVTRWYRAPEV 196 L Y+H GII+RDLK N+ ++ + +K+ D+G+ R D+ T + T Y APE Sbjct: 123 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTST-FCGTPNYIAPE- 180 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFK---GSDHLDQLKE 237 IL Y +VD W++G +M EM+ G++ F SD+ DQ E Sbjct: 181 ILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTE 224 >2R2P-A nrPDB Length = 295 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 31/226 (13%) Query: 14 QEVTKTAWEVRAVYRDLQPV-GSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAK 69 Q V + A E+ A ++ V G+G +G VCS + G+ VAIK L + +E + Sbjct: 10 QAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY-TEKQRR 68 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR 129 E ++ H N+I L V T + + T++ L +K ++ Sbjct: 69 DFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEY-----MENGSLDTFLK-----KND 118 Query: 130 IQFLVYQML-------KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR------ 176 QF V Q++ G++Y+ G +HRDL N+ +N + K+ DFGL+R Sbjct: 119 GQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP 178 Query: 177 -QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 A + G + RW APE I + ++T D+WS G +M E+++ Sbjct: 179 EAAYTTRGGKIPIRW-TAPEAIA-FRKFTSASDVWSYGIVMWEVVS 222 >4XEY-B nrPDB Length = 408 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 107/225 (47%), Gaps = 36/225 (16%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G YG V V + VA+K L + E F K A ++K ++H N++ LL Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA----AVMKEIKHPNLVQLLG 188 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLKGLRYIH 145 V T + FY++ FM G L+ + +++ + ++ Q+ + Y+ Sbjct: 189 VCTRE------PPFYIITEFM--TYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 240 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVT---------RWYRAPEV 196 IHRDL N V E+ +K+ DFGL+R MTG T +W APE Sbjct: 241 KKNFIHRDLAARNCLVGENHLVKVADFGLSRL----MTGDTYTAHAGAKFPIKW-TAPES 295 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK 240 L + +++ D+W+ G ++ E+ T G + + G D L Q+ E+++ Sbjct: 296 -LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 338 >6NPU-A nrPDB Length = 298 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 32/223 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G YG V V + VA+K L + E F K A ++K ++H N++ LL Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA----AVMKEIKHPNLVQLLG 89 Query: 92 VFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 V T + FY++ FM D + +++ + ++ Q+ + Y+ Sbjct: 90 VCTRE------PPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 143 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVT---------RWYRAPEVIL 198 IHRDL N V E+ +K+ DFGL+R MTG T +W APE L Sbjct: 144 NFIHRDLAARNCLVGENHLVKVADFGLSRL----MTGDTYTAHAGAKFPIKW-TAPES-L 197 Query: 199 NWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK 240 + +++ D+W+ G ++ E+ T G + + G D L Q+ E+++ Sbjct: 198 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 239 >4K33-A nrPDB Length = 325 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/238 (28%), Positives = 108/238 (45%), Gaps = 35/238 (14%) Query: 21 WEV-RAVYRDLQPVGSGAYGAVCSA----VDGRTGAK---VAIKKLYRPFQSELFAKRAY 72 WE+ RA +P+G GA+G V A +D AK VA+K L + + Sbjct: 31 WELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLV- 89 Query: 73 RELRLLKHM-RHENVIGLLDVFTPDETL---------DDFTDFYLVMPFMGTDLGKLMKH 122 E+ ++K + +H+N+I LL T L + +F G D Sbjct: 90 SEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYS--FDT 147 Query: 123 EKLGEDRIQF-----LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ 177 K E+++ F YQ+ +G+ Y+ + IHRDL N+ V ED +KI DFGLAR Sbjct: 148 SKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 207 Query: 178 ADS------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 + G + +W APE + + + YT D+WS G ++ E+ T G + + G Sbjct: 208 VHNLDYYKETTNGRLPVKWM-APEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPG 263 >3C51-A nrPDB Length = 543 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 104/222 (46%), Gaps = 17/222 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA-KRAYRELRLLKHMRHEN 85 + D + +G G +G V + TG A KKL + + + A E ++L + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM-----KHEKLGEDRIQFLVYQMLK 139 ++ L F TD LVM M G D+ + + E R F Q++ Sbjct: 247 IVSLAYAFETK------TDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSEMTGYVVTRWYRAPEV 196 GL ++H II+RDLKP N+ +++D ++I D GLA + ++ GY T + APE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 +L Y +VD +++G + EMI + F+ + KE+ Sbjct: 361 LLG-EEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKEL 401 >5B2L-A nrPDB Length = 324 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 102/210 (48%), Gaps = 15/210 (7%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +L +GSG G V +TG +A+K++ R E KR +L ++ ++ + Sbjct: 21 NLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEE-NKRILMDLDVV--LKSHDCPY 77 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYI-H 145 ++ F T TD ++ M MGT KL K + + E + + ++K L Y+ Sbjct: 78 IVQCFG---TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE 134 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLA-RQADSEM-TGYVVTRWYRAPEVI----LN 199 G+IHRD+KP N+ ++E ++K+ DFG++ R DS+ T Y APE I Sbjct: 135 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 194 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 Y D+WS+G + E+ TG+ +K Sbjct: 195 KPDYDIRADVWSLGISLVELATGQFPYKNC 224 >3PLS-A nrPDB Length = 298 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 110/228 (48%), Gaps = 29/228 (12%) Query: 24 RAVYRDLQPVGSGAYGAVCSA--VD-GRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLK 79 R V + +G G +G V +D + + AIK L R +E+ A+ RE L++ Sbjct: 20 RVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSR--ITEMQQVEAFLREGLLMR 77 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHEKLG---EDRIQFLVY 135 + H NV+ L+ + P E L ++++P+M DL + ++ + +D I F + Sbjct: 78 GLNHPNVLALIGIMLPPEGLP-----HVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGL- 131 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRWYRAP 194 Q+ +G+ Y+ +HRDL N ++E +K+ DFGLAR D E Y + +R Sbjct: 132 QVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDRE---YYSVQQHRHA 188 Query: 195 EVILNWM--------RYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLD 233 + + W R+T D+WS G ++ E++T G ++ D D Sbjct: 189 RLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFD 236 >2Y6O-A nrPDB Length = 291 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 116/249 (46%), Gaps = 26/249 (10%) Query: 14 QEVTKTAWEVRAVYRDLQPV-GSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAK 69 Q V + A E+ A ++ V G G +G VCS V G+ VAIK L + + + Sbjct: 2 QAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK--QR 59 Query: 70 RAY-RELRLLKHMRHENVIGLLDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEKL 125 R + E ++ H N+I L V T P + ++ + + F+ + G+ + + Sbjct: 60 RDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLV 119 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-------QA 178 G ++ + G++Y+ +HRDL N+ VN + K+ DFG++R A Sbjct: 120 G------MLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAA 173 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKE 237 + G + RW APE I + ++T D+WS G +M E+++ G+ + + D +K Sbjct: 174 YTTRGGKIPIRW-TAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKA 231 Query: 238 IMKVTGTPP 246 I + PP Sbjct: 232 IEEGYRLPP 240 >3GQL-A nrPDB Length = 326 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 103/233 (44%), Gaps = 46/233 (19%) Query: 31 QPVGSGAYGAVCSAV-------DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 +P+G GA+G V A KVA+K L + +E E+ ++K + + Sbjct: 34 KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGK 92 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-------------------- 122 H+N+I LL T D L Y+++ + G L ++ Sbjct: 93 HKNIINLLGACTQDGPL------YVIVEYASK--GNLREYLQARRPPGLEYCYNPSHNPE 144 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---- 178 E+L + YQ+ +G+ Y+ + IHRDL N+ V ED +KI DFGLAR Sbjct: 145 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 204 Query: 179 --DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 G + +W APE + + + YT D+WS G ++ E+ T G + + G Sbjct: 205 YYKKTTNGRLPVKWM-APEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG 255 >2X7G-A nrPDB Length = 389 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 83/367 (22%), Positives = 148/367 (40%), Gaps = 90/367 (24%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN- 85 Y ++ +G G + V D + VA+K + ++ + + A E++LLK +R + Sbjct: 33 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESDP 89 Query: 86 -------VIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLM---KHEKLGEDRIQFL 133 V+ L+D F + ++ M F +G L K + ++ L ++ + Sbjct: 90 SDPNKDMVVQLIDDFK----ISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSI 145 Query: 134 VYQMLKGLRYIHA-AGIIHRDLKPGNLAVNED---------------------------- 164 + Q+L+GL Y+H+ IIH D+KP N+ + D Sbjct: 146 IRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVS 205 Query: 165 -------------------CELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ 205 +KI D G A T + TR YR+ EV++ Y+ Sbjct: 206 TAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYST 264 Query: 206 TVDIWSVGCIMAEMITGKTLFK---GSDHL---DQLKEIMKVTGTPPAEFVQRLQSDEAK 259 DIWS C+ E+ TG LF+ G D+ D + I+++ G+ P F L ++ Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFA--LSGKYSR 322 Query: 260 NY------MKGLPELEKKDFASILTNA-------SPLAVNLLEKMLVLDAEQRVTAGEAL 306 + ++ + +L+ +L + + L ML + E+R +AGE L Sbjct: 323 EFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECL 382 Query: 307 AHPYFES 313 HP+ S Sbjct: 383 RHPWLNS 389 >2FO0-A nrPDB Length = 495 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 107/225 (47%), Gaps = 36/225 (16%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G YG V V + VA+K L + E F K A ++K ++H N++ LL Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA----AVMKEIKHPNLVQLLG 280 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLKGLRYIH 145 V T + FY++ FM G L+ + +++ + ++ Q+ + Y+ Sbjct: 281 VCTRE------PPFYIITEFM--TYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 332 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVT---------RWYRAPEV 196 IHR+L N V E+ +K+ DFGL+R MTG T +W APE Sbjct: 333 KKNFIHRNLAARNCLVGENHLVKVADFGLSRL----MTGDTYTAHAGAKFPIKW-TAPES 387 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK 240 L + +++ D+W+ G ++ E+ T G + + G D L Q+ E+++ Sbjct: 388 -LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE 430 >4XCU-A nrPDB Length = 300 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 103/221 (46%), Gaps = 31/221 (14%) Query: 31 QPVGSGAYGAVCSA-------VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 +P+G G +G V A + VA+K L + A E+ ++K + R Sbjct: 23 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD-LVSEMEVMKLIGR 81 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLV----- 134 H+N+I LL V T + L + +V +L + ++ + E + F V Sbjct: 82 HKNIINLLGVCTQEGPL-----YVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCA 136 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA------DSEMTGYVVT 188 YQ+ +G++Y+ + IHRDL N+ V ED +KI DFGLAR G + Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 196 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +W APE + + + YT D+WS G ++ E+ T G + + G Sbjct: 197 KWM-APEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPG 235 >3TT0-A nrPDB Length = 382 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 30/225 (13%) Query: 31 QPVGSGAYGAVCSAV-------DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 +P+G GA+G V A KVA+K L + +E E+ ++K + + Sbjct: 75 KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGK 133 Query: 83 HENVIGLLDVFTPDETL---------DDFTDFYLVMPFMGTDLGKLMKH---EKLGEDRI 130 H+N+I LL T D L + ++ G + H E+L + Sbjct: 134 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDL 193 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA------DSEMTG 184 YQ+ +G+ Y+ + IHRDL N+ V ED +KI DFGLAR G Sbjct: 194 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 253 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 + +W APE + + + YT D+WS G ++ E+ T G + + G Sbjct: 254 RLPVKWM-APEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG 296 >4JLC-A nrPDB Length = 657 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 35/240 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA V +TG A+K RP ++ RE +LK + H+N++ Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 69 Query: 88 GLLDVFTPDETLDDFTDFYLVMPF-----MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 L + T L+M F + T L + L E ++ ++ G+ Sbjct: 70 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 143 YIHAAGIIHRDLKPGNL--AVNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEV 196 ++ GI+HRD+KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 197 ----IL---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPA 247 +L + +Y TVD+WSVG TG F+ + + KE+M +TG P Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 245 >3CJF-A nrPDB Length = 309 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 108/223 (48%), Gaps = 31/223 (13%) Query: 31 QPVGSGAYGAVCSA----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE-N 85 +P+G GA+G V A +D + K+ + + + EL++L H+ H N Sbjct: 33 KPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLN 92 Query: 86 VIGLLDVFT----PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED--RIQFLV---YQ 136 V+ LL T P + +F F + ++ + + + ++ L +D ++ L+ +Q Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQ 152 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA----------RQADSEMTGYV 186 + KG+ ++ + IHRDL N+ ++E +KI DFGLA R+ D+ + Sbjct: 153 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLP--- 209 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +W APE I + + YT D+WS G ++ E+ + G + + G Sbjct: 210 -LKWM-APETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPG 249 >5A46-A nrPDB Length = 386 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 99/225 (44%), Gaps = 30/225 (13%) Query: 31 QPVGSGAYGAVCSAV-------DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 +P+G G +G V A KVA+K L + +E E+ ++K + + Sbjct: 46 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML-KSDATEKDLSDLISEMEMMKMIGK 104 Query: 83 HENVIGLLDVFTPDETL---------DDFTDFYLVMPFMGTDLGKLMKH---EKLGEDRI 130 H+N+I LL T D L + ++ G + H E+L + Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA------DSEMTG 184 YQ+ +G+ Y+ + IHRDL N+ V ED +KI DFGLAR G Sbjct: 165 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 224 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 + +W APE + + + YT D+WS G ++ E+ T G + + G Sbjct: 225 RLPVKWM-APEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPG 267 >4YFF-A nrPDB Length = 311 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 93/205 (45%), Gaps = 19/205 (9%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRP--FQSELFAKRAYRELRLLKHMRHENVIGLL 90 +GSG++G V GR K+ K YR + S+ RE+ +L + H VI + Sbjct: 50 IGSGSFGKV---YKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFV 106 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQM--LKGLRYIH-- 145 L+D + F +V ++ G L L+ +K D L+ + KG+ Y+H Sbjct: 107 GA-----CLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNL 161 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWYRAPEVILNWM 201 IIHRDL N+ + ED + DFG +R S MT + APEV Sbjct: 162 TQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCT 221 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLF 226 RYT D++S + E++TG+ F Sbjct: 222 RYTIKADVFSYALCLWEILTGEIPF 246 >4NEU-A nrPDB Length = 333 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 60/248 (24%), Positives = 110/248 (44%), Gaps = 26/248 (10%) Query: 35 SGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFT 94 SG +G V S RT + +K +Y+ + E +++ +RH V+ LL V Sbjct: 34 SGGFGKV-SLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII 92 Query: 95 PDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQF-LVYQMLKGLRYIHAAGIIHR 152 + + LVM +M +L ++K E ++ ++ ++++G+ Y+H G+IH+ Sbjct: 93 EE------GKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHK 146 Query: 153 DLKPGNLAVNEDCELKILDFGLA----------------RQADSEMTGYVVTRWYRAPEV 196 DLKP N+ V+ D +KI D GLA R+ D T +Y APE Sbjct: 147 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 206 Query: 197 ILNW-MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 + + + T+ D++S ++ + K ++ + QL +K P + + Sbjct: 207 LNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCP 266 Query: 256 DEAKNYMK 263 E + MK Sbjct: 267 REIISLMK 274 >5LOH-A nrPDB Length = 341 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 131/300 (43%), Gaps = 55/300 (18%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL----LKHMRHEN 85 ++P+ GA+G V G+ G K+ K+ + ++++ K +++ L + Sbjct: 41 VKPISRGAFGKVYL---GQKGGKLYAVKVVK--KADMINKNMTHQVQAERDALALSKSPF 95 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRY 143 ++ L +L + YLVM ++ G D+ L+ + E+ + ++ L Y Sbjct: 96 IVHLY------YSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDY 149 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR---QADSEMTGYVVTRW------YRAP 194 +H GIIHRDLKP N+ ++ + +K+ DFGL++ D M + TR Y AP Sbjct: 150 LHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 E++L + VD W++G + E +TG F TP F L+ Sbjct: 210 ELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDE--------------TPQQVFQNILK 254 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 D PE E+K L++ + AV +L L +D +R E HP F + Sbjct: 255 RDIP------WPEGEEK-----LSDNAQSAVEIL---LTIDDTKRAGMKELKRHPLFSDV 300 >4AW2-A nrPDB Length = 437 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 66/231 (28%), Positives = 111/231 (48%), Gaps = 22/231 (9%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA-YRELR-LLKHM 81 R + L+ +G GA+G V + V + KV K+ ++ A+ A +RE R +L + Sbjct: 73 REDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG 131 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMK--HEKLGEDRIQFLVYQML 138 + + L F D L YLVM + +G DL L+ ++L E+ +F + +M+ Sbjct: 132 DSKWITTLHYAFQDDNNL------YLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMV 185 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG----LARQADSEMTGYVVTRWYRAP 194 + +H +HRD+KP N+ ++ + +++ DFG L + + V T Y +P Sbjct: 186 IAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISP 245 Query: 195 EVILNWM-----RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 E IL M RY D WS+G M EM+ G+T F ++ +IM Sbjct: 246 E-ILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 295 >6GQK-A nrPDB Length = 328 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 104/222 (46%), Gaps = 30/222 (13%) Query: 33 VGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENV 86 +G+GA+G V A + VA+K L +P + EL++L ++ HEN+ Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREALMSELKVLSYLGNHENI 107 Query: 87 IGLLDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ-FLV-------- 134 + LL T P + ++ + ++ F+ + + ++ ED + FL Sbjct: 108 VNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFS 167 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-------V 187 YQ+ KG+ ++ + IHRDL N+ + KI DFGLAR ++ + YV Sbjct: 168 YQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKND-SNYVDKGNARLP 226 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +W APE I N + YT D+WS G + E+ + G + + G Sbjct: 227 VKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPG 266 >5MJB-A nrPDB Length = 305 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 106/230 (46%), Gaps = 25/230 (10%) Query: 33 VGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G+G +G V + G+ VAIK L + SE + E ++ H N+I L Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGY-SEKQRRDFLSEASIMGQFDHRNIIRL 92 Query: 90 LDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 V T P + +F + + F+ + G+ + +G ++ + G++Y+ Sbjct: 93 EGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVG------MLRGIAAGMKYLSE 146 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLAR--QAD-------SEMTGYVVTRWYRAPEVI 197 +HRDL N+ VN + K+ DFGL+R Q D S + G + RW APE I Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAPEAI 205 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPP 246 + ++T D+WS G +M E+++ G+ + + D + I + PP Sbjct: 206 A-YRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPP 254 >5O2C-A nrPDB Length = 380 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 115/251 (45%), Gaps = 14/251 (5%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA+ V +D T +VA +L ++ +R E +LK ++H N++ D Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 92 Query: 93 FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG-- 148 + + L LV M GT L + + + ++ Q+LKGL+++H Sbjct: 93 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 150 Query: 149 IIHRDLKPGNLAVNEDC-ELKILDFGLARQADSEMTGYVV-TRWYRAPEVILNWMRYTQT 206 IIHRDLK N+ + +KI D GLA + V+ T + APE+ Y ++ Sbjct: 151 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDES 208 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT-GTPPAEFVQRLQSDEAKNYMKGL 265 VD+++ G M EM T + + + Q+ KVT G PA F ++ E K ++G Sbjct: 209 VDVYAFGMCMLEMATSEYPYSECQNAAQI--YRKVTSGIKPASF-NKVTDPEVKEIIEGC 265 Query: 266 PELEKKDFASI 276 K + SI Sbjct: 266 IRQNKSERLSI 276 >4P5Q-A nrPDB Length = 361 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 97/208 (46%), Gaps = 34/208 (16%) Query: 33 VGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 VG+G +G VCS + + VAIK L + +E + E ++ H N+I L Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRRDFLGEASIMGQFDHPNIIRL 99 Query: 90 LDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQML-------KG 140 V T + + +V +M G+ L KH+ QF V Q++ G Sbjct: 100 EGVVTKSKPV------MIVTEYMENGSLDSFLRKHDA------QFTVIQLVGMLRGIASG 147 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-------QADSEMTGYVVTRWYRA 193 ++Y+ G +HRDL N+ +N + K+ DFGL+R A + G + RW + Sbjct: 148 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TS 206 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT 221 PE I + ++T D+WS G ++ E+++ Sbjct: 207 PEAIA-YRKFTSASDVWSYGIVLWEVMS 233 >2RIO-A nrPDB Length = 434 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 78/319 (24%), Positives = 138/319 (43%), Gaps = 82/319 (25%) Query: 33 VGSGAYGAVC--SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGL 89 +G G+ G V + GR VA+K++ F A E++LL H NVI Sbjct: 23 LGYGSSGTVVFQGSFQGRP---VAVKRMLIDF-----CDIALMEIKLLTESDDHPNVIR- 73 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF--------LVYQMLKGL 141 + ET D F Y+ + +L L++ + + ++ ++ L+ Q+ G+ Sbjct: 74 ---YYCSETTDRF--LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 142 RYIHAAGIIHRDLKPGNLAVN-------------EDCELKILDFGLARQADSEMTGYVV- 187 ++H+ IIHRDLKP N+ V+ E+ + I DFGL ++ DS + + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 188 ------TRWYRAPEV------ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQ 234 T +RAPE+ + R T+++DI+S+GC+ +++ GK F Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD------ 242 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL--AVNLLEKML 292 + N ++G+ L++ L + S + A +L+ +M+ Sbjct: 243 -------------------KYSRESNIIRGIFSLDE---MKCLHDRSLIAEATDLISQMI 280 Query: 293 VLDAEQRVTAGEALAHPYF 311 D +R TA + L HP F Sbjct: 281 DHDPLKRPTAMKVLRHPLF 299 >4G3E-A nrPDB Length = 352 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 66/221 (29%), Positives = 101/221 (45%), Gaps = 31/221 (14%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 YR+EV + R VG G++G V D +TG + A+KK+ + E+F Sbjct: 69 YREEVHWMTHQPR--------VGRGSFGEVHRMKDKQTGFQCAVKKV----RLEVFR--- 113 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRI 130 EL + ++ L ++ F + G LG+L+K L EDR Sbjct: 114 VEELVACAGLSSPRIVPLYGAVREGPWVNIFMEL-----LEGGSLGQLIKQMGCLPEDRA 168 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED-CELKILDFG--LARQAD----SEMT 183 + + Q L+GL Y+H I+H D+K N+ ++ D + DFG L Q D S +T Sbjct: 169 LYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLT 228 Query: 184 GYVV--TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 G + T + APEV++ VDIWS C+M M+ G Sbjct: 229 GDYIPGTETHMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNG 268 >4EUT-A nrPDB Length = 396 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 105/240 (43%), Gaps = 35/240 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA V +TG AIK RP ++ RE +LK + H+N++ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 70 Query: 88 GLLDVFTPDETLDDFTDFYLVMPF-----MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 L + T L+M F + T L + L E ++ ++ G+ Sbjct: 71 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 143 YIHAAGIIHRDLKPGNL--AVNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEV 196 ++ GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 197 ----IL---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPA 247 +L + +Y TVD+WS+G TG F+ + + KE+M +TG P Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 246 >6NT9-A nrPDB Length = 742 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 105/240 (43%), Gaps = 35/240 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA V +TG AIK RP ++ RE +LK + H+N++ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 68 Query: 88 GLLDVFTPDETLDDFTDFYLVMPF-----MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 L + T L+M F + T L + L E ++ ++ G+ Sbjct: 69 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 143 YIHAAGIIHRDLKPGNL--AVNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEV 196 ++ GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 197 ----IL---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPA 247 +L + +Y TVD+WS+G TG F+ + + KE+M +TG P Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 244 >4HVI-A nrPDB Length = 314 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 100/206 (48%), Gaps = 28/206 (13%) Query: 33 VGSGAYGAV--C--SAVDGRTGAKVAIKKLYR--PFQSELFAKRAYRELRLLKHMRHENV 86 +G G +G+V C + TGA VA+K+L P Q F RE+++LK + + + Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ----REIQILKALHSDFI 73 Query: 87 IGLLDV-FTPDETLDDFTDFYLVMPFMGTDLGK--LMKHE-KLGEDRIQFLVYQMLKGLR 142 + V + P LVM ++ + + L +H +L R+ Q+ KG+ Sbjct: 74 VKYRGVSYGPGRQ-----SLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGME 128 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR-------WYRAPE 195 Y+ + +HRDL N+ V + +KI DFGLA+ + YVV WY APE Sbjct: 129 YLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY-APE 187 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT 221 + + + +++ D+WS G ++ E+ T Sbjct: 188 SLSDNI-FSRQSDVWSFGVVLYELFT 212 >5X02-A nrPDB Length = 347 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 101/227 (44%), Gaps = 48/227 (21%) Query: 33 VGSGAYGAVCSAVD---GRTGA--KVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENV 86 +GSGA+G V +A +TG +VA+K L S + EL+++ + HEN+ Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSE-REALMSELKMMTQLGSHENI 114 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL-MKHEKLGEDRIQF----------- 132 + LL T + YL+ + G L L K EK ED I++ Sbjct: 115 VNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 168 Query: 133 -----------LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 YQ+ KG+ ++ +HRDL N+ V +KI DFGLAR S+ Sbjct: 169 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 228 Query: 182 MTGYVV-------TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 + YVV +W APE + + YT D+WS G ++ E+ + Sbjct: 229 -SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 272 >4GS6-A nrPDB Length = 315 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/204 (32%), Positives = 92/204 (45%), Gaps = 26/204 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAK-VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 VG GA+G VC A + AK VAIK++ +SE K ELR L + H N++ L Sbjct: 17 VGRGAFGVVCKA---KWRAKDVAIKQI----ESESERKAFIVELRQLSRVNHPNIVKLYG 69 Query: 92 VFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKL---GEDRIQFLVYQMLKGLRYIHA 146 LVM + G+ L E L Q +G+ Y+H+ Sbjct: 70 AC--------LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHS 121 Query: 147 ---AGIIHRDLKPGNLA-VNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMR 202 +IHRDLKP NL V LKI DFG A + MT + + APEV Sbjct: 122 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG-SN 180 Query: 203 YTQTVDIWSVGCIMAEMITGKTLF 226 Y++ D++S G I+ E+IT + F Sbjct: 181 YSEKCDVFSWGIILWEVITRRKPF 204 >5O2B-A nrPDB Length = 285 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 70/251 (27%), Positives = 115/251 (45%), Gaps = 14/251 (5%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA+ V +D T +VA +L ++ +R E +LK ++H N++ D Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDS 83 Query: 93 FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG-- 148 + + L LV M GT L + + + ++ Q+LKGL+++H Sbjct: 84 W--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPP 141 Query: 149 IIHRDLKPGNLAVNEDC-ELKILDFGLARQADSEMTGYVV-TRWYRAPEVILNWMRYTQT 206 IIHRDLK N+ + +KI D GLA + V+ T + APE+ Y ++ Sbjct: 142 IIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEE--HYDES 199 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT-GTPPAEFVQRLQSDEAKNYMKGL 265 VD+++ G M EM T + + + Q+ KVT G PA F ++ E K ++G Sbjct: 200 VDVYAFGMCMLEMATSEYPYSECQNAAQIYR--KVTSGIKPASF-NKVTDPEVKEIIEGC 256 Query: 266 PELEKKDFASI 276 K + SI Sbjct: 257 IRQNKSERLSI 267 >4EUU-A nrPDB Length = 319 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 107/240 (44%), Gaps = 35/240 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA V +TG AIK RP ++ RE +LK + H+N++ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 70 Query: 88 GLLDVFTPDETLDDFTDFYLVMPF-----MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 L + +ET L+M F + T L + L E ++ ++ G+ Sbjct: 71 KLFAI--EEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 143 YIHAAGIIHRDLKPGNL--AVNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEV 196 ++ GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 197 ----IL---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPA 247 +L + +Y TVD+WS+G TG F+ + + KE+M +TG P Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 246 >2BUJ-A nrPDB Length = 317 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 104/218 (47%), Gaps = 26/218 (11%) Query: 27 YRDLQPVGSGAYGAVCSAVDG-RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y +Q +G G + V V+G G A+K++ Q + + A RE + + H N Sbjct: 31 YLFIQKLGEGGFSYV-DLVEGLHDGHFYALKRILCHEQQD--REEAQREADMHRLFNHPN 87 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM----KHEKLGEDRIQFLVYQMLK 139 ++ L+ + + +L++PF GT ++ K L ED+I +L+ + + Sbjct: 88 ILRLVAYCLRERGAKH--EAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICR 145 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG----YVVTRW----- 190 GL IHA G HRDLKP N+ + ++ + ++D G QA + G + W Sbjct: 146 GLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRC 205 Query: 191 ---YRAPEV--ILNWMRYTQTVDIWSVGCIMAEMITGK 223 YRAPE+ + + + D+WS+GC++ M+ G+ Sbjct: 206 TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGE 243 >4XUF-A nrPDB Length = 297 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 101/227 (44%), Gaps = 48/227 (21%) Query: 33 VGSGAYGAVCSAVD---GRTGA--KVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENV 86 +GSGA+G V +A +TG +VA+K L S + EL+++ + HEN+ Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSE-REALMSELKMMTQLGSHENI 75 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL-MKHEKLGEDRIQF----------- 132 + LL T + YL+ + G L L K EK ED I++ Sbjct: 76 VNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEED 129 Query: 133 -----------LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 YQ+ KG+ ++ +HRDL N+ V +KI DFGLAR S+ Sbjct: 130 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 189 Query: 182 MTGYVV-------TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 + YVV +W APE + + YT D+WS G ++ E+ + Sbjct: 190 -SNYVVRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 233 >4CSV-A nrPDB Length = 275 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 111/228 (48%), Gaps = 20/228 (8%) Query: 21 WEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 WE+ R+ + +GSG +G V +VA+K L + + + +E +++K Sbjct: 6 WEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQIMK 62 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHE--KLGEDRIQFLVY 135 ++H N++ L V T + + Y++ +M G+ L L E + + + Sbjct: 63 KLKHPNLVQLYGVCTKEPPI------YIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA 116 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS-EMTGYVVTRW---Y 191 Q+ G+ Y+ + IHRDL N V E+ +K+ DFGLAR + E T ++ + Sbjct: 117 QVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKW 176 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 APE I ++ R++ D+W+ G ++ E+ T G+ + G + ++++ Sbjct: 177 TAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQV 223 >6O8B-A nrPDB Length = 665 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 105/240 (43%), Gaps = 35/240 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIK-----KLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA V +TG AIK RP ++ RE +LK + H+N++ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQM------REFEVLKKLNHKNIV 76 Query: 88 GLLDVFTPDETLDDFTDFYLVMPF-----MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 L + T L+M F + T L + L E ++ ++ G+ Sbjct: 77 KLFAIEEETTTRHKV----LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 143 YIHAAGIIHRDLKPGNL--AVNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEV 196 ++ GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 197 ----IL---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK--VTGTPPA 247 +L + +Y TVD+WS+G TG F+ + + KE+M +TG P Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSG 252 >5U6B-A nrPDB Length = 307 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 100/217 (46%), Gaps = 21/217 (9%) Query: 33 VGSGAYGAVCSAVDGRTGA--KVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G +GAV + + KVA+K + + + E +K H NV+ L+ Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 91 DVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQML--------KGL 141 V + F +++PFM DL + + +LG D+ +L QML G+ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLG-DQPVYLPTQMLVKFMADIASGM 149 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVV---TRWYRAPE 195 Y+ IHRDL N +NE+ + + DFGL+++ D G + +W A E Sbjct: 150 EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI-AIE 208 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 + + + YT D+WS G M E+ T G+T + G ++ Sbjct: 209 SLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVEN 244 >5AMN-A nrPDB Length = 299 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 92/212 (43%), Gaps = 32/212 (15%) Query: 33 VGSGAYGAVCSA----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V A + GR G K+ + S + E +LK + H +VI Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 90 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE-----------DRIQFLVYQM 137 L + D L ++ G+ G L + K+G D I F +Q+ Sbjct: 91 LYGACSQDGPLLLIVEY----AKYGSLRGFLRESRKVGPGYPDERALTMGDLISF-AWQI 145 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVI 197 +G++Y+ ++HRDL N+ V E ++KI DFGL+R E YV R P Sbjct: 146 SQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE-DSYVKRSQGRIP--- 201 Query: 198 LNWMR--------YTQTVDIWSVGCIMAEMIT 221 + WM YT D+WS G ++ E++T Sbjct: 202 VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 233 >4PDO-A nrPDB Length = 299 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/204 (29%), Positives = 98/204 (48%), Gaps = 25/204 (12%) Query: 33 VGSGAYGAVCSAV----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G+G +G V + G+ VAIK L + +E E ++ H N+I Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY-TEKQRVDFLGEAGIMGQFSHHNIIR 100 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG----LRYI 144 L V + + + T++ L K ++ EK GE + LV ML+G ++Y+ Sbjct: 101 LEGVISKYKPMMIITEY-----MENGALDKFLR-EKDGEFSVLQLV-GMLRGIAAGMKYL 153 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLAR--QADSEMT-----GYVVTRWYRAPEVI 197 +HRDL N+ VN + K+ DFGL+R + D E T G + RW APE I Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPEAI 212 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT 221 ++ ++T D+WS G +M E++T Sbjct: 213 -SYRKFTSASDVWSFGIVMWEVMT 235 >2XYN-A nrPDB Length = 292 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 106/225 (47%), Gaps = 36/225 (16%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G YG V V + VA+K L + E F K A ++K ++H N++ LL Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEA----AVMKEIKHPNLVQLLG 95 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLKGLRYIH 145 V T + FY+V +M G L+ + E++ + ++ Q+ + Y+ Sbjct: 96 VCTLE------PPFYIVTEYM--PYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 147 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVT---------RWYRAPEV 196 IHRDL N V E+ +K+ DFGL+R MTG T +W APE Sbjct: 148 KKNFIHRDLAARNCLVGENHVVKVADFGLSRL----MTGDTYTAHAGAKFPIKW-TAPES 202 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK 240 L + ++ D+W+ G ++ E+ T G + + G D L Q+ ++++ Sbjct: 203 -LAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLE 245 >4Y83-A nrPDB Length = 332 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 83/307 (27%), Positives = 128/307 (41%), Gaps = 60/307 (19%) Query: 15 EVTKTAWEV--RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL----YRPFQSELFA 68 +V W++ R + D P GA+G V A D +T ++A K + ++P E+ A Sbjct: 63 DVLLIPWKLTYRNIGSDFIP--RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQA 120 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 RHEN+ L ET+ F + G+ L KL + E Sbjct: 121 C-----------FRHENIAELYGAVLWGETVHLFME----AGEGGSVLEKLESCGPMREF 165 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGY 185 I ++ +LKGL ++H+ +IH D+KP N+ V + ++DFGL+ Q ++ Sbjct: 166 EIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTEDVYFPKDL 224 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 T Y +PEVIL T+ DI+S+G + M TGTP Sbjct: 225 RGTEIYMSPEVILCRGHSTKA-DIYSLGATLIHM---------------------QTGTP 262 Query: 246 PAEFVQRLQSDEAKNYM----KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 P +V+R +Y+ K P LE I + SP L+E L + R Sbjct: 263 P--WVKRYPRSAYPSYLYIIHKQAPPLE-----DIADDCSPGMRELIEASLERNPNHRPR 315 Query: 302 AGEALAH 308 A + L H Sbjct: 316 AADLLKH 322 >3TKU-A nrPDB Length = 433 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 106/230 (46%), Gaps = 20/230 (8%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R + ++ +G GA+G V + V + ++ K+ ++ KRA E + R Sbjct: 89 REDFEIIKVIGRGAFGEV-AVVKMKNTERIYAMKILNKWE---MLKRA--ETACFREERD 142 Query: 84 ENVIGLLDVFTP-DETLDDFTDFYLVMPF-MGTDLGKLMK--HEKLGEDRIQFLVYQMLK 139 V G T D YLVM + +G DL L+ +KL ED +F + +M+ Sbjct: 143 VLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 202 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY----VVTRWYRAPE 195 + IH +HRD+KP N+ ++ + +++ DFG + + + T V T Y +PE Sbjct: 203 AIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPE 262 Query: 196 VILNWM-----RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 IL M +Y D WS+G M EM+ G+T F ++ +IM Sbjct: 263 -ILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 311 >4F9B-A nrPDB Length = 361 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 104/240 (43%), Gaps = 66/240 (27%) Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQADS---EMTGYVV---- 187 + K L+ IH GI+HRD+KP N N + ++DFGLA+ E+ +V Sbjct: 125 NLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQ 184 Query: 188 ------------------------TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 T +RAPEV+ T +D+WS G I +++G+ Sbjct: 185 QERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGR 244 Query: 224 -TLFKGSDHLDQLKEIMKVTGT-------------------PPAEFVQRLQSDEAKNYMK 263 +K SD L L +IM + G+ PA+ +++L ++ Sbjct: 245 YPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKL-----CERLR 299 Query: 264 GLPELEKKDFASILTNASPL---------AVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 G+ K + I +A+ L A +LL+K+L L+ R+TA EAL HP+F+ + Sbjct: 300 GMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >2H34-A nrPDB Length = 309 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 101/216 (46%), Gaps = 16/216 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRHEN 85 YR + VG G G V A D VA+K + S+ +F R RE R ++ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYI 144 V+ + D D L + D L+ G DL +++ + L R +V Q+ L Sbjct: 96 VVPIHDFGEIDGQL--YVDMRLIN---GVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAA 150 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILNW 200 HAAG HRD+KP N+ V+ D ++DFG+A E + V T +Y APE + Sbjct: 151 HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FSE 209 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 T DI+++ C++ E +TG ++G DQL Sbjct: 210 SHATYRADIYALTCVLYECLTGSPPYQG----DQLS 241 >1NY3-A nrPDB Length = 400 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 127/295 (43%), Gaps = 51/295 (17%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE---NVI 87 Q +G G G V + RT K A+K L +A RE+ L H R +++ Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVEL--HWRASQCPHIV 118 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLKGL 141 ++DV+ + +VM + D G+L + E ++ + + + Sbjct: 119 RIVDVY--ENLYAGRKCLLIVMECL--DGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 Query: 142 RYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTRWYRAPEV 196 +Y+H+ I HRD+KP NL + LK+ DFG A++ S +T T +Y APEV Sbjct: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 L +Y ++ D+WS+G IM ++ G F S+H + MK R++ Sbjct: 235 -LGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKT----------RIRM- 281 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 G E +++ + L NLL+ + QR+T E + HP+ Sbjct: 282 -------GQYEFPNPEWSEVSEEVKMLIRNLLKT----EPTQRMTITEFMNHPWI 325 >2OZA-A nrPDB Length = 356 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 125/297 (42%), Gaps = 55/297 (18%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 Q +G G G V + RT K A+K L +A RE+ L H R ++ Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVEL--HWRASQCPHIV 74 Query: 91 DVFTPDETLDDFTDFY-----LVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLK 139 + +D + + Y L++ D G+L + E ++ + + Sbjct: 75 RI------VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTRWYRAP 194 ++Y+H+ I HRD+KP NL + LK+ DFG A++ S +T T +Y AP Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 188 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV L +Y ++ D+WS+G IM ++ G F S+H + MK R++ Sbjct: 189 EV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKT----------RIR 236 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 G E +++ + L NLL+ + QR+T E + HP+ Sbjct: 237 M--------GQYEFPNPEWSEVSEEVKMLIRNLLKT----EPTQRMTITEFMNHPWI 281 >3KA0-A nrPDB Length = 320 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 125/297 (42%), Gaps = 55/297 (18%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 Q +G G G V + RT K A+K L +A RE+ L H R ++ Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVEL--HWRASQCPHIV 72 Query: 91 DVFTPDETLDDFTDFY-----LVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLK 139 + +D + + Y L++ D G+L + E ++ + + Sbjct: 73 RI------VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTRWYRAP 194 ++Y+H+ I HRD+KP NL + LK+ DFG A++ S +T T +Y AP Sbjct: 127 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAP 186 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV L +Y ++ D+WS+G IM ++ G F S+H + MK R++ Sbjct: 187 EV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKT----------RIR 234 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 G E +++ + L NLL+ + QR+T E + HP+ Sbjct: 235 M--------GQYEFPNPEWSEVSEEVKMLIRNLLKT----EPTQRMTITEFMNHPWI 279 >5GRN-A nrPDB Length = 356 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 107/231 (46%), Gaps = 38/231 (16%) Query: 33 VGSGAYGAVCSAVD-----GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENV 86 +GSGA+G V + KVA+K L +P + EL+++ H+ H N+ Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQALMSELKIMTHLGPHLNI 112 Query: 87 IGLLDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEK-----------LGEDRIQF 132 + LL T P + ++ + ++ ++ + + H+K L +D + Sbjct: 113 VNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEG 172 Query: 133 LV--------YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR------QA 178 L YQ+ +G+ ++ + +HRDL N+ + + +KI DFGLAR Sbjct: 173 LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY 232 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 S+ + ++ +W APE I + + YT D+WS G ++ E+ + G T + G Sbjct: 233 VSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSLGGTPYPG 281 >3QD2-B nrPDB Length = 332 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 71/298 (23%), Positives = 120/298 (40%), Gaps = 79/298 (26%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +Q +G G +G V A + AIK++ P EL ++ RE++ L + H + Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGI 66 Query: 87 IGLLDVF--TPDETL----------DDFTDFYLVMPF----------------MGTDLGK 118 + + + TP E D+ TD+ L P +G+ Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 119 L---------------MKHEKLG---------EDR----IQFLVYQMLKGLRYIHAAGII 150 L + E L EDR + Q+ + + ++H+ G++ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 151 HRDLKPGNLAVNEDCELKILDFGLARQADSE---------------MTGYVVTRWYRAPE 195 HRDLKP N+ D +K+ DFGL D + TG V T+ Y +PE Sbjct: 187 HRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPE 246 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP-PAEFVQR 252 I + Y+ VDI+S+G I+ E+ L+ S +++++ I V P F Q+ Sbjct: 247 QI-HGNNYSHKVDIFSLGLILFEL-----LYSFSTQMERVRIITDVRNLKFPLLFTQK 298 >4PWN-A nrPDB Length = 274 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/251 (26%), Positives = 116/251 (46%), Gaps = 13/251 (5%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G++ V +D T +VA +L ++ +R E +LK ++H N++ D Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDS 77 Query: 93 FTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG-- 148 + + T+ LV M GT L + + + ++ Q+LKGL+++H Sbjct: 78 W--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPP 135 Query: 149 IIHRDLKPGNLAVNEDC-ELKILDFGLA--RQADSEMTGYVVTRWYRAPEVILNWMRYTQ 205 IIHRDLK N+ + +KI D GLA + S + T + APE+ +Y + Sbjct: 136 IIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDE 193 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 +VD+++ G M EM T + + + Q+ + +G PA F ++ E K ++G Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRV-TSGVKPASF-DKVAIPEVKEIIEGC 251 Query: 266 PELEKKDFASI 276 K + SI Sbjct: 252 IRQNKDERYSI 262 >3KUL-B nrPDB Length = 325 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 92/202 (45%), Gaps = 22/202 (10%) Query: 33 VGSGAYGAVCSA---VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +GSG G VC V G+ VAIK L + +E + E ++ H N+I L Sbjct: 57 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQFDHPNIIRL 115 Query: 90 LDVFTPDE---TLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 V T + ++ + + F+ T G+ + +G ++ + G+RY+ Sbjct: 116 EGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVG------MLRGVGAGMRYLSD 169 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLAR-------QADSEMTGYVVTRWYRAPEVILN 199 G +HRDL N+ V+ + K+ DFGL+R A + G + RW APE I Sbjct: 170 LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW-TAPEAI-A 227 Query: 200 WMRYTQTVDIWSVGCIMAEMIT 221 + ++ D+WS G +M E++ Sbjct: 228 FRTFSSASDVWSFGVVMWEVLA 249 >6CTH-A nrPDB Length = 309 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 103/214 (48%), Gaps = 23/214 (10%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 +V + + +G G +G+V + +A+KK+ R + + K E++++ + Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGI--KEYASEVKIISRL 69 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLV-YQMLK- 139 RH+N++ L+ + + LV FM G L H G+ + + V Y+++K Sbjct: 70 RHKNLVKLIG------WCHERGELMLVYEFMAN--GSLDSHIFKGKSLLTWEVRYRIVKD 121 Query: 140 ---GLRYIHAAG---IIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTR 189 L Y+H G ++HRD+K N+ ++ K+ DFGLAR D + T T Sbjct: 122 LASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTV 181 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 Y APE L+ + ++ D++S G + E+ +G+ Sbjct: 182 GYMAPEC-LSSGKASKESDVYSFGVVALEIASGR 214 >4XI2-A nrPDB Length = 446 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 28/204 (13%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 L+ +G+G +G V R VAIK + SE E +++ ++ HE ++ L Sbjct: 192 LKELGTGQFGVVKYG-KWRGQYDVAIKMIREGSMSE---DEFIEEAKVMMNLSHEKLVQL 247 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLK-------GLR 142 V T + +++ +M G L+ + L E R +F Q+L+ + Sbjct: 248 YGVCTKQRPI------FIITEYMAN--GCLLNY--LREMRHRFQTQQLLEMCKDVCEAME 297 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVT----RWYRAPEVI 197 Y+ + +HRDL N VN+ +K+ DFGL+R D E T V + RW +P + Sbjct: 298 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRW--SPPEV 355 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT 221 L + +++ DIW+ G +M E+ + Sbjct: 356 LMYSKFSSKSDIWAFGVLMWEIYS 379 >2QKW-B nrPDB Length = 321 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 98/206 (47%), Gaps = 27/206 (13%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G +G V V R GAKVA+K+ R +S + E+ L RH +++ L+ Sbjct: 47 IGHGVFGKVYKGVL-RDGAKVALKR--RTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKH---------EKLGEDRIQFLVYQMLKGLRY 143 D+ + L+ +M + G L +H E R++ + +GL Y Sbjct: 104 ------CDERNEMILIYKYM--ENGNLKRHLYGSDLPTMSMSWEQRLEICI-GAARGLHY 154 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVV--TRWYRAPEVIL 198 +H IIHRD+K N+ ++E+ KI DFG++++ D VV T Y PE + Sbjct: 155 LHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI 214 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKT 224 R T+ D++S G ++ E++ ++ Sbjct: 215 KG-RLTEKSDVYSFGVVLFEVLCARS 239 >5WNO-A nrPDB Length = 330 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 97/208 (46%), Gaps = 20/208 (9%) Query: 33 VGSGAYGAVCSAVDGRTGAK-----VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G+GA+G V + + AK VAIK +++ QS+ E + +RH+N++ Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIK-VFQTDQSQ--TDEMLEEATNMFRLRHDNLL 86 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 ++ D+ L T + P + E LG YQ+ G++Y+ Sbjct: 87 KIIGFCMHDDGLKIVT---IYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQ 143 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLAR----QADSEM--TGYVVTRWYRAPEVILNWM 201 ++HRDL N+ V + ++I DFGL++ ADS +G V +W I + Sbjct: 144 RVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIE--IFSKH 201 Query: 202 RYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 YT D+W+ G E+IT G++ ++G Sbjct: 202 CYTHASDVWAFGVTCWEIITFGQSPYQG 229 >4CRS-A nrPDB Length = 341 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 106/241 (43%), Gaps = 26/241 (10%) Query: 36 GAYGAVCSAVDGRTGAKVAIKKLYR-------PFQSELFAKRAYRELRLLKHMRHENVIG 88 G +G V A T AIK L + S + KR + + +RH ++ Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFE---TVNSVRHPFLVN 79 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 L F E + VM + G DL + + E R F ++ GL+Y+H Sbjct: 80 LFACFQTKEHV------CFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEH 133 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNWMRYT 204 I++RDLK NL ++ + +KI DFGL ++ + + T + APEV L YT Sbjct: 134 KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV-LTETSYT 192 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 + VD W +G ++ EM+ G++ F G D + I+ P R S EA + M+ Sbjct: 193 RAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYP-----RFLSTEAISIMRR 247 Query: 265 L 265 L Sbjct: 248 L 248 >3BEA-A nrPDB Length = 333 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 101/213 (47%), Gaps = 29/213 (13%) Query: 33 VGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAY-RELRLLKHM-RHEN 85 +G+GA+G V A G KVA+K L ++ K A EL+++ H+ +HEN Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMSELKIMSHLGQHEN 111 Query: 86 VIGLLDVFT---PDETLDDFTDFYLVMPFM-------GTDLGKLMKHEKLGEDRIQFLVY 135 ++ LL T P + ++ + ++ F+ TD + + L + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSS 171 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-------T 188 Q+ +G+ ++ + IHRD+ N+ + KI DFGLAR ++ + Y+V Sbjct: 172 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIVKGNARLPV 230 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 +W APE I + + YT D+WS G ++ E+ + Sbjct: 231 KW-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 261 >5H2U-A nrPDB Length = 267 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 106/210 (50%), Gaps = 23/210 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +GSG +G V + + +VAIK + R + L + E++ +K +RH++++ L V Sbjct: 14 LGSGYFGEVFEGL-WKDRVQVAIKVISR--DNLLHQQMLQSEIQAMKKLRHKHILALYAV 70 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF------LVYQMLKGLRYIHA 146 + + + Y++ M G L++ + ++++ + +Q+ +G+ Y+ + Sbjct: 71 VSVGDPV------YIITELMAK--GSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 122 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRY 203 IHRDL N+ V E+ K+ DFGLAR ++ + + + APE L+ Y Sbjct: 123 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEA-LSRGHY 181 Query: 204 TQTVDIWSVGCIMAEMIT-GKTLFKG-SDH 231 + D+WS G ++ EM + G+ + G S+H Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNH 211 >4TPT-A nrPDB Length = 303 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 94/213 (44%), Gaps = 34/213 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G +G TG + +K+L R E K E+++++ + H NV+ + V Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIR--CDEETQKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--GEDRIQFLVYQMLKGLRYIHAAGII 150 D+ L+ T++ G L ++ + +++F + G+ Y+H+ II Sbjct: 66 LYKDKKLNLLTEY-----IEGGTLKDFLRSMDPFPWQQKVRF-AKGIASGMAYLHSMCII 119 Query: 151 HRDLKPGNLAVNEDCELKILDFGLAR---------------------QADSEMTGYVV-- 187 HRDL N + D + + DFGL+R + + Y V Sbjct: 120 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 179 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI 220 ++ APE +LN Y +TVDI+S G ++ E+I Sbjct: 180 NPYWMAPE-MLNGKSYDETVDIFSFGIVLCEII 211 >3FXW-A nrPDB Length = 336 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 97/201 (48%), Gaps = 19/201 (9%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL-RLLKHMRHENVIGL 89 Q +G G G V RTG K A+K LY + +A +E+ + +++ + Sbjct: 35 QVLGLGVNGKVLECFHRRTGQKCALKLLYD-------SPKARQEVDHHWQASGGPHIVCI 87 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDRIQFLVYQMLKGLRYIH 145 LDV+ + ++M M G +L ++ + E ++ + ++++H Sbjct: 88 LDVY--ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 145 Query: 146 AAGIIHRDLKPGNL---AVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNWM 201 + I HRD+KP NL + +D LK+ DFG A++ + + T +Y APEV L Sbjct: 146 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEV-LGPE 204 Query: 202 RYTQTVDIWSVGCIMAEMITG 222 +Y ++ D+WS+G IM ++ G Sbjct: 205 KYDKSCDMWSLGVIMYILLCG 225 >3LZB-A nrPDB Length = 327 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 98/206 (47%), Gaps = 19/206 (9%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMR 82 ++ ++ +GSGA+G V + G KV AIK+L R S K E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 75 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQMLKGL 141 + +V LL + T+ T MPF G L + +H + +G + Q+ KG+ Sbjct: 76 NPHVCRLLGICL-TSTVQLITQL---MPF-GCLLDYVREHKDNIGSQYLLNWCVQIAKGM 130 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------VVTRWYRAPE 195 Y+ ++HRDL N+ V +KI DFGLA+ +E Y V +W A E Sbjct: 131 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-ALE 189 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT 221 IL+ + YT D+WS G + E++T Sbjct: 190 SILHRI-YTHQSDVWSYGVTVWELMT 214 >5XD6-A nrPDB Length = 305 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 32/211 (15%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G+YG V + ++G AIKKL Q + + ++ ++ +R ENV+ LL Sbjct: 30 IGEGSYGRVFYGIL-KSGKAAAIKKLDSSKQPD---QEFLAQVSMVSRLRQENVVALLGY 85 Query: 93 ------------FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 + P+ +L D + G G ++ + R++ V +G Sbjct: 86 CVDGPLRVLAYEYAPNGSLHDI--LHGRKGVKGAQPGPVLSWHQ----RVKIAV-GAARG 138 Query: 141 LRYIHAAG---IIHRDLKPGNLAVNEDCELKILDFGLARQADS-----EMTGYVVTRWYR 192 L Y+H +IHRD+K N+ + +D KI DF L+ QA T + T Y Sbjct: 139 LEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYH 198 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 APE + T++ D++S G ++ E++TG+ Sbjct: 199 APEYAMTGTLSTKS-DVYSFGVVLLELLTGR 228 >6E4F-A nrPDB Length = 290 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 28/204 (13%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 L+ +G+G +G V R VAIK + SE E +++ ++ HE ++ L Sbjct: 36 LKELGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSHEKLVQL 91 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLK-------GLR 142 V T + +++ +M G L+ + L E R +F Q+L+ + Sbjct: 92 YGVCTKQRPI------FIITEYMAN--GCLLNY--LREMRHRFQTQQLLEMCKDVCEAME 141 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVT----RWYRAPEVI 197 Y+ + +HRDL N VN+ +K+ DFGL+R D E T V + RW +P + Sbjct: 142 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRW--SPPEV 199 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT 221 L + +++ DIW+ G +M E+ + Sbjct: 200 LMYSKFSSKSDIWAFGVLMWEIYS 223 >6FER-A nrPDB Length = 309 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 78/166 (46%), Gaps = 24/166 (14%) Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHE-------- 123 +E++++ ++ N+I LL V D+ L T++ DL + + +HE Sbjct: 72 KEIKIMSRLKDPNIIHLLAVCITDDPLCMITEY-----MENGDLNQFLSRHEPPNSSSSD 126 Query: 124 --KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS- 180 + ++F+ Q+ G++Y+ + +HRDL N V ++ +KI DFG++R S Sbjct: 127 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG 186 Query: 181 ---EMTGYVV--TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 + G V RW ++L ++T D+W+ G + E T Sbjct: 187 DYYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT 230 >5LPZ-A nrPDB Length = 332 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 101/212 (47%), Gaps = 38/212 (17%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +GSG +G V A+ + G+ VAIKKL S + E+ + ++H N++ LL Sbjct: 25 IGSGGFGDVYKAIL-KDGSAVAIKKLIH--VSGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 93 F-TPDETLDDFTDFYLVMPFMGTDLGKLMKHE------KLGEDRIQFLVYQMLKGLRYIH 145 DE L LV FM + + H+ KL + + +GL ++H Sbjct: 82 CKVGDERL-------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 146 ---AAGIIHRDLKPGNLAVNEDCELKILDFGLAR---QADSEMT--------GYVVTRWY 191 + IIHRD+K N+ ++E+ E ++ DFG+AR D+ ++ GYV +Y Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 ++ R + D++S G ++ E++TGK Sbjct: 195 QS-------FRCSTKGDVYSYGVVLLELLTGK 219 >3KRL-A nrPDB Length = 335 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 102/215 (47%), Gaps = 31/215 (14%) Query: 33 VGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAY-RELRLLKHM-RHEN 85 +G+GA+G V A G KVA+K L ++ K A EL+++ H+ +HEN Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMSELKIMSHLGQHEN 111 Query: 86 VIGLLDVFT---PDETLDDFTDFYLVMPFM------GTDLGKLMKH---EKLGEDRIQFL 133 ++ LL T P + ++ + ++ F+ G + H E+L + Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHF 171 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV------ 187 Q+ +G+ ++ + IHRD+ N+ + KI DFGLAR ++ + Y+V Sbjct: 172 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIVKGNARL 230 Query: 188 -TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 +W APE I + + YT D+WS G ++ E+ + Sbjct: 231 PVKW-MAPESIFDCV-YTVQSDVWSYGILLWEIFS 263 >5LPV-A nrPDB Length = 296 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 101/212 (47%), Gaps = 38/212 (17%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +GSG +G V A+ + G+ VAIKKL S + E+ + ++H N++ LL Sbjct: 25 IGSGGFGDVYKAIL-KDGSAVAIKKLIH--VSGQGDREFMAEMETIGKIKHRNLVPLLGY 81 Query: 93 F-TPDETLDDFTDFYLVMPFMGTDLGKLMKHE------KLGEDRIQFLVYQMLKGLRYIH 145 DE L LV FM + + H+ KL + + +GL ++H Sbjct: 82 CKVGDERL-------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH 134 Query: 146 ---AAGIIHRDLKPGNLAVNEDCELKILDFGLAR---QADSEMT--------GYVVTRWY 191 + IIHRD+K N+ ++E+ E ++ DFG+AR D+ ++ GYV +Y Sbjct: 135 HNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY 194 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 ++ R + D++S G ++ E++TGK Sbjct: 195 QS-------FRCSTKGDVYSYGVVLLELLTGK 219 >3QGY-A nrPDB Length = 286 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 100/217 (46%), Gaps = 19/217 (8%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +Q +GSG +G V KVAIK + SE E ++ + H ++ L Sbjct: 32 VQEIGSGQFGLVHLGY-WLNKDKVAIKTIKEGSMSE---DDFIEEAEVMMKLSHPKLVQL 87 Query: 90 LDVF---TPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 V P + +F + + ++ T G LG + + +G+ Y+ Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLG------MCLDVCEGMAYLEE 141 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEVILNWMR 202 A +IHRDL N V E+ +K+ DFG+ R D + T T++ + +PEV ++ R Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV-FSFSR 200 Query: 203 YTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 Y+ D+WS G +M E+ + GK ++ + + +++I Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 237 >3PP0-A nrPDB Length = 338 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 91/208 (43%), Gaps = 25/208 (12%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIK---KLYRPFQSELFAKRAYRELRLLKHMRHE 84 R ++ +GSGA+G V + G V I K+ R S K E ++ + Sbjct: 20 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP 79 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQFLVYQMLK 139 V LL + T+ T MP+ G L+ H +LG + Q+ K Sbjct: 80 YVSRLLGICL-TSTVQLVTQL---MPY-----GCLLDHVRENRGRLGSQDLLNWCMQIAK 130 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------VVTRWYRA 193 G+ Y+ ++HRDL N+ V +KI DFGLAR D + T Y V +W A Sbjct: 131 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWM-A 189 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT 221 E IL R+T D+WS G + E++T Sbjct: 190 LESILR-RRFTHQSDVWSYGVTVWELMT 216 >3SXS-A nrPDB Length = 268 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 95/199 (47%), Gaps = 18/199 (9%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 L+ +GSG +G V + VA+K + SE ++E + + + H ++ Sbjct: 13 LKELGSGQFGVV-KLGKWKGQYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSHPKLVKF 68 Query: 90 LDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYIHA 146 V + + + Y+V ++ G L L H K L ++ + Y + +G+ ++ + Sbjct: 69 YGVCSKEYPI------YIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEVILNWMR 202 IHRDL N V+ D +K+ DFG+ R D + V T++ + APEV ++ + Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV-FHYFK 181 Query: 203 YTQTVDIWSVGCIMAEMIT 221 Y+ D+W+ G +M E+ + Sbjct: 182 YSSKSDVWAFGILMWEVFS 200 >5FM2-A nrPDB Length = 355 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 92/226 (40%), Gaps = 46/226 (20%) Query: 33 VGSGAYGAVCSA----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V A + GR G K+ + S + E +LK + H +VI Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 131 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE--------------------- 127 L + D L ++ G+ G L + K+G Sbjct: 132 LYGACSQDGPLLLIVEYAKY----GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 128 ----DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 D I F +Q+ +G++Y+ ++HRDL N+ V E ++KI DFGL+R E Sbjct: 188 LTMGDLISF-AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE-D 245 Query: 184 GYVVTRWYRAPEVILNWMR--------YTQTVDIWSVGCIMAEMIT 221 YV R P + WM YT D+WS G ++ E++T Sbjct: 246 SYVKRSQGRIP---VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 288 >5TOS-A nrPDB Length = 395 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 107/242 (44%), Gaps = 39/242 (16%) Query: 22 EVRAVYRDLQP---VGSGAYGAV---------CSAVDGRTGAKVAIKKLYRP-FQSELFA 68 E++ R+ +P +G G +G V + TG +A+KKL + FQ Sbjct: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--- 115 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLG 126 + E+ L + H N++ L+ DE LV FM G+ L + Sbjct: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDE------HRLLVYEFMQKGSLENHLFRRGAYF 169 Query: 127 EDRIQFLVYQML----KGLRYIHA--AGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 + FL + KGL ++H+ +I+RD+K N+ ++ D K+ DFGLAR Sbjct: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 Query: 181 EMTGYVVTR-----WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 YV TR Y APE + + ++ D++S G ++ E+++GK + DH Sbjct: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGK---RALDHNRPA 285 Query: 236 KE 237 KE Sbjct: 286 KE 287 >5GNK-A nrPDB Length = 297 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 21/207 (10%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMR 82 ++ ++ +GSGA+G V + G KV AIK+L R S K E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 83 HENVIGLLDVFTPDETLDDFTDFYL-VMPFMGTDLGKLMKH-EKLGEDRIQFLVYQMLKG 140 + +V LL + L + +MPF G L + +H + +G + Q+ KG Sbjct: 80 NPHVCRLLGI-----CLTSTVQLIMQLMPF-GCLLDYVREHKDNIGSQYLLNWCVQIAKG 133 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------VVTRWYRAP 194 + Y+ ++HRDL N+ V +KI DFGLA+ +E Y V +W A Sbjct: 134 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM-AL 192 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMIT 221 E IL+ + YT D+WS G + E++T Sbjct: 193 ESILHRI-YTHQSDVWSYGVTVWELMT 218 >4Y93-A nrPDB Length = 446 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 97/203 (47%), Gaps = 26/203 (12%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 L+ +G+G +G V R VAIK + SE E +++ ++ HE ++ L Sbjct: 193 LKELGTGQFGVV-KYGKWRGQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSHEKLVQL 248 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLK-------GLR 142 V T + +++ +M G L+ + L E R +F Q+L+ + Sbjct: 249 YGVCTKQRPI------FIITEYMAN--GCLLNY--LREMRHRFQTQQLLEMCKDVCEAME 298 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEVIL 198 Y+ + +HRDL N VN+ +K+ DFG+ R D E T +++ + +PEV++ Sbjct: 299 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLM 358 Query: 199 NWMRYTQTVDIWSVGCIMAEMIT 221 + +++ DIW+ G +M E+ + Sbjct: 359 -YSKFSSKSDIWAFGVLMWEIYS 380 >4X7Q-B nrPDB Length = 312 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 9/149 (6%) Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGL 141 H VI LLD F ET + F L P DL + + LGE + Q++ + Sbjct: 97 HPGVIRLLDWF---ETQEGFM-LVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAI 152 Query: 142 RYIHAAGIIHRDLKPGNLAVN--EDCELKILDFGL-ARQADSEMTGYVVTRWYRAPEVIL 198 ++ H+ G++HRD+K N+ ++ C K++DFG A D T + TR Y PE I Sbjct: 153 QHCHSRGVVHRDIKDENILIDLRRGCA-KLIDFGSGALLHDEPYTDFDGTRVYSPPEWIS 211 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFK 227 + +WS+G ++ +M+ G F+ Sbjct: 212 RHQYHALPATVWSLGILLYDMVCGDIPFE 240 >3QUP-A nrPDB Length = 323 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 101/223 (45%), Gaps = 32/223 (14%) Query: 33 VGSGAYGAVCSAV----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G+V A DG + KVA+K L + + RE +K H +V Sbjct: 31 LGKGEFGSVREAQLKQEDG-SFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAK 89 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDR----IQFLVYQMLK---G 140 L+ V +++PFM DL + ++GE+ +Q LV M+ G Sbjct: 90 LVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACG 149 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYR---APEVI 197 + Y+ + IHRDL N + ED + + DFGL+R+ S +YR A ++ Sbjct: 150 MEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYS-------GDYYRQGCASKLP 202 Query: 198 LNWMR--------YTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 + W+ YT D+W+ G M E++T G+T + G ++ Sbjct: 203 VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIEN 245 >2OGV-A nrPDB Length = 317 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 101/210 (48%), Gaps = 27/210 (12%) Query: 33 VGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAY-RELRLLKHM-RHEN 85 +G+GA+G V A G KVA+K L ++ K A EL+++ H+ +HEN Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMSELKIMSHLGQHEN 103 Query: 86 VIGLLDVFT---PDETLDDFTDFYLVMPFM----GTDLGKLMKHEKLGEDRIQFLVYQML 138 ++ LL T P + ++ + ++ F+ DL K D + F Q+ Sbjct: 104 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHF-SSQVA 162 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-------TRWY 191 +G+ ++ + IHRD+ N+ + KI DFGLAR ++ + Y+V +W Sbjct: 163 QGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNYIVKGNARLPVKW- 220 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 APE I + + YT D+WS G ++ E+ + Sbjct: 221 MAPESIFDCV-YTVQSDVWSYGILLWEIFS 249 >4OTD-A nrPDB Length = 341 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 104/226 (46%), Gaps = 23/226 (10%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM----- 81 ++ L +G G +G V + +G AIK L + ++ A+ L K + Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKK---GDIVARDEVESLMCEKRILAAVT 70 Query: 82 --RHENVIGLLDVF-TPDETLDDFTDFYLVMPF-MGTDLGKLMKHEKLGEDRIQFLVYQM 137 H ++ L F TP+ VM + G DL + + E R F + Sbjct: 71 SAGHPFLVNLFGCFQTPEHVC-------FVMEYSAGGDLMLHIHSDVFSEPRAIFYSACV 123 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAP 194 + GL+++H I++RDLK NL ++ + +KI DFGL ++ + + T + AP Sbjct: 124 VLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 EV+ + YT+ VD W +G ++ EM+ G++ F G D + I+ Sbjct: 184 EVLTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN 228 >5VD3-A nrPDB Length = 311 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 97/234 (41%), Gaps = 16/234 (6%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 ++ L +G G+YG V G A+K+ PF+ R +L + HE V Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGP-----KDRARKLAEVGSHEKV 113 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRYI 144 ++ ++ YL G L + + L E ++ + L L ++ Sbjct: 114 GQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHL 173 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR--WYRAPEVILNWMR 202 H+ G++H D+KP N+ + K+ DFGL + + G V Y APE++ Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG--S 231 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 Y D++S+G + E+ L G + QL++ G P EF L S+ Sbjct: 232 YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFTAGLSSE 280 >6FEX-A nrPDB Length = 321 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 51/188 (27%), Positives = 87/188 (46%), Gaps = 28/188 (14%) Query: 53 VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM 112 VA+K L RP ++ +E++++ ++ N+I LL V D+ L TD+ Sbjct: 60 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY-----ME 113 Query: 113 GTDLGKLMKHEKL---------GEDRIQF-----LVYQMLKGLRYIHAAGIIHRDLKPGN 158 DL + + +L G+ I + + Q+ G+RY+ +HRDL N Sbjct: 114 NGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 173 Query: 159 LAVNEDCELKILDFGLARQADS----EMTGYVV--TRWYRAPEVILNWMRYTQTVDIWSV 212 V E+ +KI DFG++R + + G V RW A E IL ++T D+W+ Sbjct: 174 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWM-AWECIL-MGKFTTASDVWAF 231 Query: 213 GCIMAEMI 220 G + E++ Sbjct: 232 GVTLWEVL 239 >3G0E-A nrPDB Length = 336 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/225 (26%), Positives = 103/225 (45%), Gaps = 34/225 (15%) Query: 33 VGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHM-RHEN 85 +G+GA+G V A + VA+K L +P + L + A EL++L ++ H N Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KP-SAHLTEREALMSELKVLSYLGNHMN 111 Query: 86 VIGLLDVFT---PDETLDDFTDFYLVMPFMGTDLGKLMKHEK-----------LGEDRIQ 131 ++ LL T P + ++ + ++ F+ + + L + + Sbjct: 112 IVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLL 171 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV---- 187 YQ+ KG+ ++ + IHRDL N+ + KI DFGLAR ++ + YVV Sbjct: 172 SFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND-SNYVVKGNA 230 Query: 188 ---TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +W APE I N + YT D+WS G + E+ + G + + G Sbjct: 231 RLPVKW-MAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPG 273 >6DBM-A nrPDB Length = 318 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/255 (24%), Positives = 110/255 (43%), Gaps = 39/255 (15%) Query: 28 RDLQPVGSGAYGAV---C-SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + ++ +G G +G V C + TG VA+K L + +E+ +L+ + H Sbjct: 34 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDILRTLYH 92 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL---MKHEKLGEDRIQFLVYQMLKG 140 E++I LVM ++ LG L + +G ++ Q+ +G Sbjct: 93 EHIIKYKGCCEDAGA----ASLQLVMEYV--PLGSLRDYLPRHSIGLAQLLLFAQQICEG 146 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR-------WYRA 193 + Y+H+ IHRDL N+ ++ D +KI DFGLA+ Y V WY A Sbjct: 147 MAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 205 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PE + + Y + D+WS G + E++T H D + +PP +F++ + Sbjct: 206 PECLKEYKFYYAS-DVWSFGVTLYELLT---------HCDS-------SQSPPTKFLELI 248 Query: 254 QSDEAKNYMKGLPEL 268 + + + L EL Sbjct: 249 GIAQGQMTVLRLTEL 263 >6J5U-C nrPDB Length = 426 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 101/228 (44%), Gaps = 37/228 (16%) Query: 27 YRDLQPVGSGAYGAV---------CSAVDGRTGAKVAIKKLYRP--FQSELFAKRAYREL 75 +R +G G +G V +A +G VA+K+L +P FQ K E+ Sbjct: 86 FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQL-KPEGFQGH---KEWLTEV 141 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLV 134 L + H N++ L+ E + LV FM G L H + G + + + Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGE------NRLLVYEFM--PKGSLENHLFRRGAQPLTWAI 193 Query: 135 YQML-----KGLRYIHAAG--IIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 + KGL ++H A +I+RD K N+ ++ D K+ DFGLA+ + +V Sbjct: 194 RMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVS 253 Query: 188 TR-----WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 T+ Y APE + R T D++S G ++ E+I+G+ S+ Sbjct: 254 TKVIGTHGYAAPEYVATG-RLTAKSDVYSFGVVLLELISGRRAMDNSN 300 >4E20-A nrPDB Length = 290 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 96/207 (46%), Gaps = 21/207 (10%) Query: 28 RDLQPVGSGAYGAV---C-SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + ++ +G G +G V C + TG VA+K L +L + RE+ +L+ + H Sbjct: 11 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ-REIEILRTLYH 69 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 E+++ D+ LVM + +G+ L +H +G ++ Q+ +G+ Sbjct: 70 EHIVKYKGC-CEDQGEKSVQ---LVMEYVPLGSLRDYLPRH-CVGLAQLLLFAQQICEGM 124 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR-------WYRAP 194 Y+HA IHR L N+ ++ D +KI DFGLA+ Y V WY AP Sbjct: 125 AYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-AP 183 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMIT 221 E L ++ D+WS G + E++T Sbjct: 184 EC-LKECKFYYASDVWSFGVTLYELLT 209 >5HLW-A nrPDB Length = 299 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 91/205 (44%), Gaps = 26/205 (12%) Query: 33 VGSGAYGAVCSAV----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V DG+ A+K L R + E ++K H NV+ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKK-IHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVLS 85 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK---HEKLGEDRIQFLVYQMLKGLRYI 144 LL + E +V+P+M DL ++ H +D I F + Q+ KG++Y+ Sbjct: 86 LLGICLRSEG-----SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL-QVAKGMKYL 139 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM--- 201 + +HRDL N ++E +K+ DFGLAR D Y ++ + WM Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR--DMHDKEYYSVHNKTGAKLPVKWMALE 197 Query: 202 -----RYTQTVDIWSVGCIMAEMIT 221 ++T D+WS G ++ E++T Sbjct: 198 SLQTQKFTTKSDVWSFGVLLWELMT 222 >1FVR-A nrPDB Length = 327 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 93/217 (42%), Gaps = 26/217 (11%) Query: 33 VGSGAYGAVCSAVDGRTGAKV--AIKKL--------YRPFQSEL--FAKRAYRE--LRLL 78 +G G +G V A + G ++ AIK++ +R F EL K + + LL Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVY 135 H + L + P L DF V+ TD + + L ++ Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLE---TDPAFAIANSTASTLSSQQLLHFAA 149 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEMTGYVVTRWYR 192 + +G+ Y+ IHRDL N+ V E+ KI DFGL+R + + G + RW Sbjct: 150 DVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMA 209 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 LN+ YT D+WS G ++ E+++ G T + G Sbjct: 210 IES--LNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG 244 >2J0K-A nrPDB Length = 656 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 96/224 (42%), Gaps = 34/224 (15%) Query: 33 VGSGAYGAVCSAV---DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G G +G V + VAIK + S+ ++ +E ++ H +++ L Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTC-KNCTSDSVREKFLQEALTMRQFDHPHIVKL 456 Query: 90 LDVFTPDE--------TLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 + V T + TL + F V F DL L+ YQ+ L Sbjct: 457 IGVITENPVWIIMELCTLGELRSFLQVRKF-SLDLASLI-----------LYAYQLSTAL 504 Query: 142 RYIHAAGIIHRDLKPGNLAVNE-DCELKILDFGLARQADSEM-----TGYVVTRWYRAPE 195 Y+ + +HRD+ N+ V+ DC +K+ DFGL+R + G + +W APE Sbjct: 505 AYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APE 562 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 I N+ R+T D+W G M E++ G F+G + D + I Sbjct: 563 SI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 >4AT3-A nrPDB Length = 299 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 99/215 (46%), Gaps = 36/215 (16%) Query: 33 VGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA+G V A + VA+K L S+ K +RE LL +++HE+++ Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA--SDNARKDFHREAELLTNLQHEHIV 78 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--------------KLGEDRIQF 132 V + L +V +M DL K ++ +L + ++ Sbjct: 79 KFYGVCVEGDPL------IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH 132 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVV- 187 + Q+ G+ Y+ + +HRDL N V E+ +KI DFG++R S + G+ + Sbjct: 133 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 192 Query: 188 -TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 RW PE I+ + ++T D+WS+G ++ E+ T Sbjct: 193 PIRWM-PPESIM-YRKFTTESDVWSLGVVLWEIFT 225 >4FL3-A nrPDB Length = 635 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 65/118 (55%), Gaps = 10/118 (8%) Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-- 176 L ++ + + I LV+Q+ G++Y+ + +HRDL N+ + KI DFGL++ Sbjct: 460 LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 Query: 177 QAD-----SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +AD ++ G +WY APE I N+ +++ D+WS G +M E + G+ ++G Sbjct: 520 RADENYYKAQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 >3V5Q-A nrPDB Length = 297 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 99/219 (45%), Gaps = 41/219 (18%) Query: 33 VGSGAYGAV----CSAVD-GRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHENV 86 +G GA+G V C + + VA+K L P L A++ + RE LL +++HE++ Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP---TLAARKDFQREAELLTNLQHEHI 79 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE-----------------KLGED 128 + V D +V +M DL K ++ +LG Sbjct: 80 VKFYGV------CGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLS 133 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTG 184 ++ + Q+ G+ Y+ + +HRDL N V + +KI DFG++R S + G Sbjct: 134 QMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGG 193 Query: 185 YVV--TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 + + RW PE I+ + ++T D+WS G I+ E+ T Sbjct: 194 HTMLPIRWM-PPESIM-YRKFTTESDVWSFGVILWEIFT 230 >4M66-A nrPDB Length = 325 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 101/214 (47%), Gaps = 23/214 (10%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R + L+ VG G +G V A VA+K + +K+ E++ + ++R+ Sbjct: 19 REELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRN 70 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ENV+ LL V T D D + LV FM G+ G L + L+ +++ G+ Sbjct: 71 ENVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGM 129 Query: 142 RYIHA--AGIIHRDLKPGNLAVNEDCELKILDFGLA---------RQADSEMTGYVVTRW 190 Y+H+ ++HRDLKP N+ ++ + K+ DFGL+ + S T Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 191 YRAPEVILNW-MRYTQTVDIWSVGCIMAEMITGK 223 Y PE++ ++ ++ D++S G ++ ++ G+ Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >3ZZW-A nrPDB Length = 289 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 96/203 (47%), Gaps = 25/203 (12%) Query: 39 GAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK-HMRHENVIGLLDVFTPDE 97 G + G VAIK L + L + +R +L+ ++H NV+ LL V T D+ Sbjct: 28 GHLFGPAPGEQTQAVAIKTLKDKAEGPL--REEFRHEAMLRARLQHPNVVCLLGVVTKDQ 85 Query: 98 TLDDFTDF--------YLVMPFMGTDLG-----KLMKHEKLGEDRIQFLVYQMLKGLRYI 144 L + +LVM +D+G + +K D + LV Q+ G+ Y+ Sbjct: 86 PLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVH-LVAQIAAGMEYL 144 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVV--TRWYRAPEVIL 198 + ++H+DL N+ V + +KI D GL R+ + ++ G + RW APE I+ Sbjct: 145 SSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWM-APEAIM 203 Query: 199 NWMRYTQTVDIWSVGCIMAEMIT 221 + +++ DIWS G ++ E+ + Sbjct: 204 -YGKFSIDSDIWSYGVVLWEVFS 225 >4R7H-A nrPDB Length = 343 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 60/223 (26%), Positives = 103/223 (46%), Gaps = 40/223 (17%) Query: 33 VGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAY-RELRLLKHM-RHEN 85 +G+GA+G V A G KVA+K L ++ K A EL+++ H+ +HEN Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD--EKEALMSELKIMSHLGQHEN 115 Query: 86 VIGLLDVFT---PDETLDDFTDFYLVMPFM--------GTDLGKLMKHEKLGE------- 127 ++ LL T P + ++ + ++ F+ G L E L + Sbjct: 116 IVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLE 175 Query: 128 --DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY 185 D + F Q+ +G+ ++ + IHRD+ N+ + KI DFGLAR ++ + Y Sbjct: 176 LRDLLHF-SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND-SNY 233 Query: 186 VV-------TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 +V +W APE I + + YT D+WS G ++ E+ + Sbjct: 234 IVKGNARLPVKWM-APESIFDSV-YTVQSDVWSYGILLWEIFS 274 >4EBW-A nrPDB Length = 304 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 96/223 (43%), Gaps = 32/223 (14%) Query: 33 VGSGAYGAVCSAV---DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G G +G V + VAIK + S+ ++ +E ++ H +++ L Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTC-KNCTSDSVREKFLQEALTMRQFDHPHIVKL 104 Query: 90 LDVFTPDE--------TLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 + V T + TL + F V + DL L+ + YQ+ L Sbjct: 105 IGVITENPVWIIMELCTLGELRSFLQVRKY-SLDLASLILY-----------AYQLSTAL 152 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM-----TGYVVTRWYRAPEV 196 Y+ + +HRD+ N+ V+ + +K+ DFGL+R + G + +W APE Sbjct: 153 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APES 211 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 I N+ R+T D+W G M E++ G F+G + D + I Sbjct: 212 I-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 >3Q4U-A nrPDB Length = 301 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 39/224 (17%) Query: 24 RAVYRD---LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK- 79 R V RD L+ VG G YG V G VA+K S K +RE L Sbjct: 4 RTVARDITLLECVGKGRYGEVWRG--SWQGENVAVKIF-----SSRDEKSWFRETELYNT 56 Query: 80 -HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE-DRIQFL--VY 135 +RHEN++G + + + T +L+ + ++G L + +L D + L V Sbjct: 57 VMLRHENILGF--IASDMTSRHSSTQLWLITHYH--EMGSLYDYLQLTTLDTVSCLRIVL 112 Query: 136 QMLKGLRYIHAA--------GIIHRDLKPGNLAVNEDCELKILDFGLA-------RQADS 180 + GL ++H I HRDLK N+ V ++ + I D GLA Q D Sbjct: 113 SIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDV 172 Query: 181 EMTGYVVTRWYRAPEVI-----LNWMRYTQTVDIWSVGCIMAEM 219 V T+ Y APEV+ ++ + VDIW+ G ++ E+ Sbjct: 173 GNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV 216 >4LRM-A nrPDB Length = 334 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 98/209 (46%), Gaps = 22/209 (10%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE-------LRLLK 79 ++ ++ +GSGA+G V + G KV I + + E + +A +E + + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVD 79 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQML 138 + + +V LL + T+ T MPF G L + +H + +G + Q+ Sbjct: 80 NPGNPHVCRLLGICL-TSTVQLITQL---MPF-GCLLDYVREHKDNIGSQYLLNWCVQIA 134 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------VVTRWYR 192 KG+ Y+ ++HRDL N+ V +KI DFGLA+ +E Y V +W Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM- 193 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMIT 221 A E IL+ + YT D+WS G + E++T Sbjct: 194 ALESILHRI-YTHQSDVWSYGVTVWELMT 221 >4OLI-A nrPDB Length = 645 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 111/255 (43%), Gaps = 39/255 (15%) Query: 28 RDLQPVGSGAYGAV---C-SAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + ++ +G G +G V C + TG VA+K L + + +E+ +L+ + H Sbjct: 356 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWK-QEIDILRTLYH 414 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL---MKHEKLGEDRIQFLVYQMLKG 140 E++I +D + L + LG L + +G ++ Q+ +G Sbjct: 415 EHIIKY------KGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEG 468 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR-------WYRA 193 + Y+H+ IHR+L N+ ++ D +KI DFGLA+ Y V WY A Sbjct: 469 MAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-A 527 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PE + + Y + D+WS G + E++T H D + +PP +F++ + Sbjct: 528 PECLKEYKFYYAS-DVWSFGVTLYELLT---------HCDS-------SQSPPTKFLELI 570 Query: 254 QSDEAKNYMKGLPEL 268 + + + L EL Sbjct: 571 GIAQGQMTVLRLTEL 585 >5C26-A nrPDB Length = 299 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 65/118 (55%), Gaps = 10/118 (8%) Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-- 176 L ++ + + I LV+Q+ G++Y+ + +HRDL N+ + KI DFGL++ Sbjct: 118 LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 177 Query: 177 QAD-----SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 +AD ++ G +WY APE I N+ +++ D+WS G +M E + G+ ++G Sbjct: 178 RADENYYKAQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 233 >3BBT-B nrPDB Length = 328 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 98/205 (47%), Gaps = 29/205 (14%) Query: 33 VGSGAYGAVCSAV---DGRT-GAKVAIKKLYRPFQSELFAKRAYRELR----LLKHMRHE 84 +GSGA+G V + +G T VAIK L +E +A E ++ M H Sbjct: 23 LGSGAFGTVYKGIWVPEGETVKIPVAIKIL-----NETTGPKANVEFMDEALIMASMDHP 77 Query: 85 NVIGLLDV-FTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 +++ LL V +P T+ T +MP G L + +H + +G + Q+ KG+ Sbjct: 78 HLVRLLGVCLSP--TIQLVTQ---LMPH-GCLLEYVHEHKDNIGSQLLLNWCVQIAKGMM 131 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------VVTRWYRAPEV 196 Y+ ++HRDL N+ V +KI DFGLAR + + Y + +W A E Sbjct: 132 YLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWM-ALEC 190 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT 221 I ++ ++T D+WS G + E++T Sbjct: 191 I-HYRKFTHQSDVWSYGVTIWELMT 214 >3MDY-A nrPDB Length = 337 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 73/285 (25%), Positives = 117/285 (41%), Gaps = 44/285 (15%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 ++ +G G YG V + G KVA+K + ++ F + + L MRHEN++G Sbjct: 42 VKQIGKGRYGEV--WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVL---MRHENILGF 96 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA-- 146 + + +T YL+ + L +K L + L Y + GL ++H Sbjct: 97 --IAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 147 ------AGIIHRDLKPGNLAVNEDCELKILDFGLA-------RQADSEMTGYVVTRWYRA 193 I HRDLK N+ V ++ I D GLA + D V T+ Y Sbjct: 155 FSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 194 PEVI---LNWMRYTQTV--DIWSVGCIMAEM----ITGKT----------LFKGSDHLDQ 234 PEV+ LN + + D++S G I+ E+ ++G L + Sbjct: 215 PEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYED 274 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYM-KGLPELEKKDFASILT 278 ++EI+ + P+ F R SDE M K + E + AS LT Sbjct: 275 MREIVCIKKLRPS-FPNRWSSDECLRQMGKLMTECWAHNPASRLT 318 >4BTK-A nrPDB Length = 337 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 102/232 (43%), Gaps = 48/232 (20%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-E 74 V K W+V L+ +G G +G + A+D T VA+K +S K+ + E Sbjct: 53 VVKDRWKV------LKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKME 101 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF-- 132 + +LK ++ ++ + +E + Y+VM G +L L + + G + Sbjct: 102 VAVLKKLQGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTL 156 Query: 133 -LVYQMLKGLRYIHAAGIIHRDLKPGNLAVN------EDCELKILDFGLARQADSEMTGY 185 L Q+L+ + IH+ G +HRD+KP N A+ C + LDFGLARQ + TG Sbjct: 157 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQY-TNTTGD 213 Query: 186 VVTRWYRAPEVILNW---MRYTQTV-----------DIWSVGCIMAEMITGK 223 V R P + + +RY D+WS+ ++ E G+ Sbjct: 214 V-----RPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 260 >4NFN-A nrPDB Length = 309 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/232 (26%), Positives = 102/232 (43%), Gaps = 48/232 (20%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-E 74 V K W+V L+ +G G +G + A+D T VA+K +S K+ + E Sbjct: 18 VVKDRWKV------LKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKME 66 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF-- 132 + +LK ++ ++ + +E + Y+VM G +L L + + G + Sbjct: 67 VAVLKKLQGKDHVCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTL 121 Query: 133 -LVYQMLKGLRYIHAAGIIHRDLKPGNLAVN------EDCELKILDFGLARQADSEMTGY 185 L Q+L+ + IH+ G +HRD+KP N A+ C + LDFGLARQ + TG Sbjct: 122 RLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYM--LDFGLARQY-TNTTGD 178 Query: 186 VVTRWYRAPEVILNW---MRYTQTV-----------DIWSVGCIMAEMITGK 223 V R P + + +RY D+WS+ ++ E G+ Sbjct: 179 V-----RPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQ 225 >4LQP-A nrPDB Length = 508 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 45/155 (29%), Positives = 77/155 (49%), Gaps = 15/155 (9%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE-N 85 + ++ +G GA+G V TG A+K L +SE++ K L H++ E + Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL---LKSEMYKKDQ------LAHVKAERD 154 Query: 86 VIGLLD---VFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFLVYQMLKG 140 V+ D V + + D YL+M F+ G DL L++ + ED +F + + + Sbjct: 155 VLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILA 214 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 + IH G IHR +KP N+ ++ +K+ DFGL+ Sbjct: 215 IETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 1/54 (1%) Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 Y APE+ L + Y Q D WS+G IM E + G F + ++IM T Sbjct: 329 YIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQT 381 >3C1X-A nrPDB Length = 373 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 91/206 (44%), Gaps = 28/206 (13%) Query: 33 VGSGAYGAVCSAV----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V DG+ A+K L R + E ++K H NV+ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKK-IHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVLS 154 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK---HEKLGEDRIQFLVYQMLKGLRYI 144 LL + E +V+P+M DL ++ H +D I F + Q+ KG++++ Sbjct: 155 LLGICLRSEG-----SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGL-QVAKGMKFL 208 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRWYRAPEVILNWM-- 201 + +HRDL N ++E +K+ DFGLAR D E + P + WM Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLP---VKWMAL 265 Query: 202 ------RYTQTVDIWSVGCIMAEMIT 221 ++T D+WS G ++ E++T Sbjct: 266 ESLQTQKFTTKSDVWSFGVLLWELMT 291 >6BSD-A nrPDB Length = 876 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 87/195 (44%), Gaps = 36/195 (18%) Query: 53 VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM 112 VA+K L RP ++ +E++++ ++ N+I LL V D+ L TD+ Sbjct: 615 VAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDY-----ME 668 Query: 113 GTDLGKLMKHEKLGEDR---------------------IQFLVYQMLKGLRYIHAAGIIH 151 DL + + +L ED+ + + Q+ G+RY+ +H Sbjct: 669 NGDLNQFLSAHQL-EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727 Query: 152 RDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVV--TRWYRAPEVILNWMRYTQ 205 RDL N V E+ +KI DFG++R + + G V RW A E IL ++T Sbjct: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWM-AWECIL-MGKFTT 785 Query: 206 TVDIWSVGCIMAEMI 220 D+W+ G + E++ Sbjct: 786 ASDVWAFGVTLWEVL 800 >2PZI-A nrPDB Length = 681 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 36/115 (31%), Positives = 65/115 (56%), Gaps = 6/115 (5%) Query: 106 YLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC 165 Y+VM ++G K K +KL + ++L L Y+H+ G+++ DLKP N+ + E+ Sbjct: 160 YIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE- 218 Query: 166 ELKILDFGLARQADSEMTGYVV-TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEM 219 +LK++D G + +S GY+ T ++APE++ T DI++VG +A + Sbjct: 219 QLKLIDLGAVSRINS--FGYLYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL 269 >4JRN-A nrPDB Length = 372 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/242 (24%), Positives = 93/242 (38%), Gaps = 51/242 (21%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIK------------------- 56 V+ T E R + R P+GSG + V A D T ++A+K Sbjct: 60 VSVTTGETRTLVRG-APLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRE 118 Query: 57 -KLYRPFQSELFAKRAYRELRLL----------KHMRHENVIGLLDVFTPDETLDDFTDF 105 YR F AK A R + + E VIGL + P+ + Sbjct: 119 SSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPN--------Y 170 Query: 106 YLVMPFMGTDLGKLM---------KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKP 156 +L+M D+ K++ + G +L Q +K + + A GI+H D+KP Sbjct: 171 FLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKP 230 Query: 157 GNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPE--VILNWMRYTQTVDIWSVGC 214 N + +D L + DFG R +S + + T Y PE + YT D W +G Sbjct: 231 ANFLLLKDGRLFLGDFGTYRINNS-VGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGI 289 Query: 215 IM 216 + Sbjct: 290 TL 291 >1U59-A nrPDB Length = 287 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 93/200 (46%), Gaps = 20/200 (10%) Query: 33 VGSGAYGAVCSAVDG--RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G +G+V V + VAIK L + + + RE +++ + + ++ L+ Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTD-LGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHAA 147 V + + LVM G L K + K E++ + L++Q+ G++Y+ Sbjct: 77 GVCQAEALM-------LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 129 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRW---YRAPEVILNWM 201 +HRDL N+ + KI DFGL++ DS T +W + APE I N+ Sbjct: 130 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFR 188 Query: 202 RYTQTVDIWSVGCIMAEMIT 221 +++ D+WS G M E ++ Sbjct: 189 KFSSRSDVWSYGVTMWEALS 208 >5L2Q-C nrPDB Length = 320 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 104/235 (44%), Gaps = 41/235 (17%) Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVY 135 R++K M+ + + +LD + D D + ++ +K ++L E + Y Sbjct: 109 RMVKKMK-KRICLVLDCLCAHDFSDKTADLINLQHYV-------IKEKRLSERETVVIFY 160 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQADSE---MTGYVVTRWY 191 +++ + +H I+HRDLK GN+ +N+ + I +F L + SE + + Y Sbjct: 161 DVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAY 220 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 +P+V+ + D+W++G ++ M+ G+ F S P E + Sbjct: 221 ISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDS---------------IPQELFR 265 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 ++++ E +PE + S V L+ K+LVLD +QR+ A + L Sbjct: 266 KIKAAEYT-----IPEDGR---------VSENTVCLIRKLLVLDPQQRLAAADVL 306 >4RT7-A nrPDB Length = 415 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 54/102 (52%), Gaps = 11/102 (10%) Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV 186 ED + F YQ+ KG+ ++ +HRDL N+ V +KI DFGLAR S+ + YV Sbjct: 243 EDLLCF-AYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD-SNYV 300 Query: 187 V-------TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 V +W APE + + YT D+WS G ++ E+ + Sbjct: 301 VRGNARLPVKW-MAPESLFEGI-YTIKSDVWSYGILLWEIFS 340 >4Y12-A nrPDB Length = 375 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 42/147 (28%), Positives = 77/147 (52%), Gaps = 11/147 (7%) Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTD--FYLVMPFMGTDLGKLMKHEKLGEDRIQFL 133 + L + H +++ +F E D D Y+VM ++G K K +KL Sbjct: 170 QFLAEVVHPSIV---QIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAY 226 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-TRWYR 192 + ++L L Y+H+ G+++ DLKP N+ + E+ +LK++D G + +S GY+ T ++ Sbjct: 227 LLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINS--FGYLYGTPGFQ 283 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEM 219 APE++ T DI++VG +A + Sbjct: 284 APEIVRTGP--TVATDIYTVGRTLAAL 308 >2WTK-B nrPDB Length = 373 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 67/300 (22%), Positives = 115/300 (38%), Gaps = 44/300 (14%) Query: 49 TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLV 108 TG V ++++ S EL + K H N++ F D L ++V Sbjct: 35 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNEL------WVV 88 Query: 109 MPFMGTDLGK--LMKH--EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED 164 FM K + H + + E I +++ +LK L YIH G +HR +K ++ ++ D Sbjct: 89 TSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVD 148 Query: 165 ---------CELKILDFGLARQADSEMTGYVVTRW-YRAPEVI-LNWMRYTQTVDIWSVG 213 L ++ G ++ + Y V + +PEV+ N Y DI+SVG Sbjct: 149 GKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVG 208 Query: 214 CIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF-VQRLQSDEAKNYMKGLPELEKKD 272 E+ G FK L E K+ GT P + ++E M + Sbjct: 209 ITACELANGHVPFKDMPATQMLLE--KLNGTVPCLLDTSTIPAEELT--MSPSRSVANSG 264 Query: 273 FASILTNASPLAVN------------------LLEKMLVLDAEQRVTAGEALAHPYFESL 314 + LT ++P N +E+ L + + R +A L H +F+ + Sbjct: 265 LSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQI 324 >5TE0-A nrPDB Length = 347 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 47/202 (23%), Positives = 93/202 (46%), Gaps = 24/202 (11%) Query: 40 AVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDET 98 A+ V G K A+K+++ + +L + RE+++++ + H+N++G +D + + Sbjct: 33 AIVFLVRTSNGMKCALKRMFVNNEHDL--QVCKREIQIMRDLSGHKNIVGYIDSSINNVS 90 Query: 99 LDDFTDFYLVMPFM-GTDLGKLMKHE---KLGEDRIQFLVYQMLKGLRYIHAAG--IIHR 152 D + ++M F G + LM E+ + + + + +H IIHR Sbjct: 91 SGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHR 150 Query: 153 DLKPGNLAVNEDCELKILDFGLARQ------------ADSEMTGYVVTRWYRAPEVI--L 198 DLK N+ +++ + DFG A + E+ Y T YRAPE++ Sbjct: 151 DLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY-TTLSYRAPEMVNLY 209 Query: 199 NWMRYTQTVDIWSVGCIMAEMI 220 + T DIW++GC++ ++ Sbjct: 210 SGKIITTKADIWALGCLLYKLC 231 >5VC6-A nrPDB Length = 289 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 35/150 (23%), Positives = 69/150 (46%), Gaps = 27/150 (18%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHEN 85 + +L+ +GSG +G+V V G AIK+ +P + + A RE+ + +H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 86 VIGLLDVFTPDETL-------------DDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF 132 V+ + D+ + D ++ Y +M + E ++ Sbjct: 73 VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSY-------------FKEAELKD 119 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVN 162 L+ Q+ +GLRYIH+ ++H D+KP N+ ++ Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFIS 149 >2OZO-A nrPDB Length = 613 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 93/200 (46%), Gaps = 20/200 (10%) Query: 33 VGSGAYGAVCSAVDG--RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 +G G +G+V V + VAIK L + + + RE +++ + + ++ L+ Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTD-LGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHAA 147 V + + LVM G L K + K E++ + L++Q+ G++Y+ Sbjct: 403 GVCQAEALM-------LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRW---YRAPEVILNWM 201 +HR+L N+ + KI DFGL++ DS T +W + APE I N+ Sbjct: 456 NFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFR 514 Query: 202 RYTQTVDIWSVGCIMAEMIT 221 +++ D+WS G M E ++ Sbjct: 515 KFSSRSDVWSYGVTMWEALS 534 >5IKW-A nrPDB Length = 310 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 48/192 (25%), Positives = 89/192 (46%), Gaps = 25/192 (13%) Query: 50 GAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLV 108 G + A+K++Y +L + RE+ ++K + H+N++G LD + D+ + ++ Sbjct: 38 GIRCALKRMYVNNMPDLNVCK--REITIMKELSGHKNIVGYLDCAV-NSISDNVWEVLIL 94 Query: 109 MPFM--GTDLGKLMKHEKLG--EDRIQFLVYQMLKGLRYIHAAG--IIHRDLKPGNLAVN 162 M + G + ++ K + G E + + + + +H IIHRDLK N+ +N Sbjct: 95 MEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLN 154 Query: 163 EDCELKILDFGLARQ------------ADSEMTGYVVTRWYRAPEVI--LNWMRYTQTVD 208 + + DFG A + E+ Y T YRAPE+I T D Sbjct: 155 DGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKY-TTLSYRAPEMINLYGGKPITTKAD 213 Query: 209 IWSVGCIMAEMI 220 IW++GC++ ++ Sbjct: 214 IWALGCLLYKLC 225 >3SOC-A nrPDB Length = 322 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 25/196 (12%) Query: 53 VAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM 112 VA+K P Q + + Y E+ L M+HEN++ + ++D D +L+ F Sbjct: 50 VAVKIF--PIQDKQSWQNEY-EVYSLPGMKHENILQFIGAEKRGTSVD--VDLWLITAFH 104 Query: 113 -GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH----------AAGIIHRDLKPGNLAV 161 L +K + + + + M +GL Y+H I HRD+K N+ + Sbjct: 105 EKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLL 164 Query: 162 NEDCELKILDFGLARQADS-----EMTGYVVTRWYRAPEVILNWMRYTQT----VDIWSV 212 + I DFGLA + ++ + G V TR Y APEV+ + + + +D++++ Sbjct: 165 KNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAM 224 Query: 213 GCIMAEMITGKTLFKG 228 G ++ E+ + T G Sbjct: 225 GLVLWELASRCTAADG 240 >3HNG-A nrPDB Length = 360 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 39/126 (30%), Positives = 68/126 (53%), Gaps = 14/126 (11%) Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR----QADSEM 182 ED I + +Q+ +G+ ++ + IHRDL N+ ++E+ +KI DFGLAR D Sbjct: 199 EDLISY-SFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVR 257 Query: 183 TG--YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG----SDHLDQL 235 G + +W APE I + + Y+ D+WS G ++ E+ + G + + G D +L Sbjct: 258 KGDTRLPLKWM-APESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL 315 Query: 236 KEIMKV 241 +E M++ Sbjct: 316 REGMRM 321 >5X1R-A nrPDB Length = 302 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 92/223 (41%), Gaps = 43/223 (19%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRP-------------FQSELFAK-------RAY 72 +G G +G V A D + +AIK+ Y P + E F K Sbjct: 29 IGEGGFGIVYRAYDHQLERTIAIKE-YMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSFI 87 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRI 130 +E RLL H ++ +L + + T T FY GT L L EK+ E I Sbjct: 88 QEARLLARFSHPGLLHVLRFWEENGTAYMGTQFY-----SGTTLKNLQAQQPEKIDEAWI 142 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT--GYVVT 188 + L+ + + IH G +HRD+ N+ + E +LDFG AR+ ++ +V Sbjct: 143 RRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETEIVL 202 Query: 189 RWYRAPEVILNWMRYTQT--------VDIWSVGCIMAEMITGK 223 + AP +YT+ DI+++G ++ +I G Sbjct: 203 KPGFAP-----IEQYTENSDGEQGPWTDIYALGAVLHTLIVGS 240 >2VD5-A nrPDB Length = 412 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 107/249 (42%), Gaps = 18/249 (7%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 L+ +G GA+ V +TG A+K + + + +RE R + I Sbjct: 66 LKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQ 125 Query: 90 LDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHA 146 L DE YLVM + +G DL L+ E++ + +F + +++ + +H Sbjct: 126 LHFAFQDENY-----LYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 180 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFG--LARQADSEMTGYVV--TRWYRAPEVI----- 197 G +HRD+KP N+ ++ +++ DFG L +AD + V T Y +PE++ Sbjct: 181 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 240 Query: 198 -LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 Y D W++G EM G+T F + +I+ V + Sbjct: 241 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPE 300 Query: 257 EAKNYMKGL 265 EA+++++ L Sbjct: 301 EARDFIQRL 309 >4C59-A nrPDB Length = 340 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 92/211 (43%), Gaps = 30/211 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMR-HENVIGLL 90 + G + V A D +G + A+K+L +E RA +E+ +K + H N++ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRL---LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFC 91 Query: 91 DVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEK----LGEDRIQFLVYQMLKGLRYI 144 + +E+ +F L+ L + +K + L D + + YQ + ++++ Sbjct: 92 SAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHM 151 Query: 145 H--AAGIIHRDLKPGNLAVNEDCELKILDFGLA---------------RQADSEMTGYVV 187 H IIHRDLK NL ++ +K+ DFG A R E Sbjct: 152 HRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNT 211 Query: 188 TRWYRAPEVILNWMRYT--QTVDIWSVGCIM 216 T YR PE+I + + + DIW++GCI+ Sbjct: 212 TPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >2PMN-X nrPDB Length = 348 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/296 (23%), Positives = 124/296 (41%), Gaps = 64/296 (21%) Query: 49 TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLV 108 K++IK Y F++EL +++ +++E + T + + ++ + Y++ Sbjct: 77 NNDKISIKSKYDDFKNEL---------QIITDIKNEYCL------TCEGIITNYDEVYII 121 Query: 109 MPFMGTDLGKLMKHEK----LGEDRIQFLVYQMLK--------GLRYIHA-AGIIHRDLK 155 +M D ++K ++ L ++ F+ Q++K YIH I HRD+K Sbjct: 122 YEYMEND--SILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVK 179 Query: 156 PGNLAVNEDCELKILDFGLAR-QADSEMTGYVVTRWYRAPEVILNWMRYT-QTVDIWSVG 213 P N+ ++++ +K+ DFG + D ++ G T + PE N Y VDIWS+G Sbjct: 180 PSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLG 239 Query: 214 CIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDF 273 + M F +K++ V+ + KN P L++ F Sbjct: 240 ICLYVMFYNVVPFS-----------LKIS------LVELFNNIRTKNI--EYP-LDRNHF 279 Query: 274 ASILTNASPLAVN---------LLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 LTN N L+ L + +R+T+ +AL H E L DT E Sbjct: 280 LYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKH---EWLADTNIE 332 >3UIM-A nrPDB Length = 326 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 32/212 (15%) Query: 33 VGSGAYGAVCSAVDGRT--GAKVAIKKLY--RPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G V GR G VA+K+L R EL + E+ ++ H N++ Sbjct: 38 LGRGGFGKVYK---GRLADGTLVAVKRLKEERTQGGEL---QFQTEVEMISMAVHRNLLR 91 Query: 89 LLD-VFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK------LGEDRIQFLVYQMLKGL 141 L TP E L LV P+M E+ L + Q + +GL Sbjct: 92 LRGFCMTPTERL-------LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGL 144 Query: 142 RYIHA---AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV----TRWYRAP 194 Y+H IIHRD+K N+ ++E+ E + DFGLA+ D + T T + AP Sbjct: 145 AYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226 E L+ + ++ D++ G ++ E+ITG+ F Sbjct: 205 E-YLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >5KMM-A nrPDB Length = 329 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 109/252 (43%), Gaps = 51/252 (20%) Query: 33 VGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHENV 86 +G GA+G V A + + VA+K L +S A++ + RE LL ++H+++ Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES---ARQDFQREAELLTMLQHQHI 99 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----------------LGEDR 129 + V T L +V +M DL + ++ LG + Sbjct: 100 VRFFGVCTEGRPL------LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQ 153 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---- 185 + + Q+ G+ Y+ +HRDL N V + +KI DFG++R D T Y Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR--DIYSTDYYRVG 211 Query: 186 ----VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLF------KGSDHLDQ 234 + RW PE IL + ++T D+WS G ++ E+ T GK + + D + Q Sbjct: 212 GRTMLPIRWM-PPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ 269 Query: 235 LKEIMKVTGTPP 246 +E+ + PP Sbjct: 270 GRELERPRACPP 281 >3LMG-A nrPDB Length = 344 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 94/207 (45%), Gaps = 23/207 (11%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR----ELRLLKHMRH 83 R L+ +GSG +G V V G + I + + + +++++ + + + H Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK-SGRQSFQAVTDHMLAIGSLDH 92 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGLR 142 +++ LL P +L T + +P +G+ L + +H LG + Q+ KG+ Sbjct: 93 AHIVRLLG-LCPGSSLQLVTQY---LP-LGSLLDHVRQHRGALGPQLLLNWGVQIAKGMY 147 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM- 201 Y+ G++HR+L N+ + ++++ DFG+A + + Y + + WM Sbjct: 148 YLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLL----YSEAKTPIKWMA 203 Query: 202 -------RYTQTVDIWSVGCIMAEMIT 221 +YT D+WS G + E++T Sbjct: 204 LESIHFGKYTHQSDVWSYGVTVWELMT 230 >5FQD-C nrPDB Length = 341 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 40/179 (22%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIK---------------KLYRP 61 +K + V Y+ ++ +GSG++G + A++ G +VA+K KLY+ Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKI 70 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK 121 Q + +R + NV+ ++D+ P +L+D +F M T L Sbjct: 71 LQGGV----GIPHIRWYGQEKDYNVL-VMDLLGP--SLEDLFNFCSRRFTMKTVL----- 118 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGN--LAVNEDC-ELKILDFGLARQ 177 L QM+ + Y+H IHRD+KP N + + C +L ++DFGLA++ Sbjct: 119 ----------MLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKK 167 >3ZBF-A nrPDB Length = 322 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 104/233 (44%), Gaps = 36/233 (15%) Query: 33 VGSGAYGAV--CSAVD----GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 +GSGA+G V +AVD G KVA+K L + ++ +E L+ H N+ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKG-STDQEKIEFLKEAHLMSKFNHPNI 99 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLG--------EDRIQFLVYQM 137 + L V +E Y+++ M G DL ++ ++ + L + Sbjct: 100 LKQLGVCLLNEPQ------YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDI 153 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVN-EDCE----LKILDFGLARQA------DSEMTGYV 186 KG Y+ IHRDL N V+ +D +KI DFGLAR G + Sbjct: 154 SKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLL 213 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 RW APE +++ + TQ+ D+WS G ++ E++T G + +LD L + Sbjct: 214 PVRWM-APESLMDGIFTTQS-DVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 264 >4H1J-A nrPDB Length = 293 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 94/204 (46%), Gaps = 18/204 (8%) Query: 33 VGSGAYGAVCSAV-DGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRHENVIGLL 90 +G G +G V V G K+ + L K + E ++K++ H +++ L+ Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLI 91 Query: 91 DVFTPDETLDDFTDFYLVMP-FMGTDLGKLMKHEKLGEDRIQFLVY--QMLKGLRYIHAA 147 + + T +++M + +LG ++ K + ++Y Q+ K + Y+ + Sbjct: 92 GIIEEEPT-------WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 144 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEVILNWMRY 203 +HRD+ N+ V +K+ DFGL+R D + VTR + +PE I N+ R+ Sbjct: 145 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NFRRF 203 Query: 204 TQTVDIWSVGCIMAEMIT-GKTLF 226 T D+W M E+++ GK F Sbjct: 204 TTASDVWMFAVCMWEILSFGKQPF 227 >1LUF-A nrPDB Length = 343 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 95/231 (41%), Gaps = 35/231 (15%) Query: 33 VGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +G GA+G V A + VA+K L +++ A RE L+ + N++ Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ-REAALMAEFDNPNIV 113 Query: 88 GLLDVFTPDETL---------DDFTDF------YLVMPFMGTDLGKLMKHEKLGEDRIQF 132 LL V + + D +F + V +DL + G + Sbjct: 114 KLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSC 173 Query: 133 -----LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---AD---SE 181 + Q+ G+ Y+ +HRDL N V E+ +KI DFGL+R AD ++ Sbjct: 174 AEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKAD 233 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 + RW PE I + RYT D+W+ G ++ E+ + G + G H Sbjct: 234 GNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 282 >5WNL-A nrPDB Length = 342 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 46/146 (31%), Positives = 71/146 (48%), Gaps = 12/146 (8%) Query: 107 LVMPFMGT-DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG--IIHRDLKPGNLAVNE 163 LVM +M T L KL+ E L D +V++ G+ ++H ++H +LKP N+ ++ Sbjct: 94 LVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDA 153 Query: 164 DCELKILDFGLAR------QADSEMTGYVVTRWYRAPEVILNWMRYTQTV-DIWSVGCIM 216 +KI DFGLA+ D M G T Y PE I R T D++S ++ Sbjct: 154 HYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVI 213 Query: 217 AEMITGKTLFKGSDHLDQLKEIMKVT 242 ++T K F +D + L +MKV Sbjct: 214 WGVLTQKKPF--ADEKNILHIMMKVV 237 >5U6C-A nrPDB Length = 315 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 100/247 (40%), Gaps = 46/247 (18%) Query: 33 VGSGAYGAVCSAV----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 +G G +G+V DG T KVA+K + S+ + E +K H NV+ Sbjct: 44 LGEGEFGSVMEGNLKQEDG-TSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMR 102 Query: 89 LLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQMLK-------G 140 LL V + + +++PFM DL + + +L + +LK G Sbjct: 103 LLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALG 161 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNW 200 + Y+ +HRDL N + +D + + DFGL+++ S Y R R ++ + W Sbjct: 162 MEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYS--GDYY--RQGRIAKMPVKW 217 Query: 201 MR--------YTQTVDIWSVGCIMAEMIT--------------------GKTLFKGSDHL 232 + YT D+W+ G M E+ T G L + D L Sbjct: 218 IAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 277 Query: 233 DQLKEIM 239 D+L EIM Sbjct: 278 DELYEIM 284 >3M42-A nrPDB Length = 299 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 68/293 (23%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE---NVI 87 Q +G G G V + RT K A+K L +A RE+ L H R +++ Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVEL--HWRASQCPHIV 74 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDRIQFLVYQMLKGL 141 ++DV+ + +VM + D G+L + E ++ + + + Sbjct: 75 RIVDVY--ENLYAGRKCLLIVMECL--DGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 142 RYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSEMTGYVVTRWYRAPEVIL 198 +Y+H+ I HRD+KP NL + LK+ DFG A++ E Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE----------------- 173 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 +Y ++ D+WS+G IM ++ G F S+H + MK R++ Sbjct: 174 ---KYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKT----------RIRM--- 216 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 G E +++ + L NLL+ + QR+T E + HP+ Sbjct: 217 -----GQYEFPNPEWSEVSEEVKMLIRNLLKT----EPTQRMTITEFMNHPWI 260 >3VHK-A nrPDB Length = 368 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 52/97 (53%), Gaps = 16/97 (16%) Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA----------RQADSEMTG 184 +Q+ KG+ ++ + IHRDL N+ ++E +KI DFGLA R+ D+ + Sbjct: 207 FQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLP- 265 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 +W APE I + + YT D+WS G ++ E+ + Sbjct: 266 ---LKWM-APETIFDRV-YTIQSDVWSFGVLLWEIFS 297 >5CEK-A nrPDB Length = 263 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 54/242 (22%), Positives = 102/242 (42%), Gaps = 50/242 (20%) Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH----EKLGEDRIQFLVYQML 138 H N+ G+++V + T Y+ F D G + + ++L E+ L Q++ Sbjct: 60 HSNITGIVEVILGE------TKAYV---FFEKDFGDMHSYVRSRKRLREEEAARLFKQIV 110 Query: 139 KGLRYIHAAGIIHRDLKPGNL--AVNEDCELKIL---DFGLARQADSEMTGYVVTRWYRA 193 + + H + I+ DLK + E +L++ D + + D ++ Y + Sbjct: 111 SAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVS 170 Query: 194 PEVILNWMRYT-QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 PE++ Y+ + D+WS+G ++ ++ G+ F SD P A F + Sbjct: 171 PEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD--------------PSALFSK- 215 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + + F I + SP A L+ +L + +R+TA E L HP+FE Sbjct: 216 ---------------IRRGQFC-IPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFE 259 Query: 313 SL 314 S+ Sbjct: 260 SV 261 >4HZS-A nrPDB Length = 341 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 91/209 (43%), Gaps = 25/209 (11%) Query: 28 RDLQPVGSGAYGAV----CSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMR 82 R L+ +G G++G V A G+T VA+K L S+ A + RE+ + + Sbjct: 15 RLLEKLGDGSFGVVRRGEWDAPSGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLD 73 Query: 83 HENVIGLLDV-FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQML 138 H N+I L V TP + + +G+ L +L KH+ LG + Q+ Sbjct: 74 HRNLIRLYGVVLTPPMKM------VTELAPLGSLLDRLRKHQGHFLLGT--LSRYAVQVA 125 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV------VTRWYR 192 +G+ Y+ + IHRDL NL + +KI DFGL R YV V + Sbjct: 126 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 185 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMIT 221 APE L ++ D W G + EM T Sbjct: 186 APES-LKTRTFSHASDTWMFGVTLWEMFT 213 >6DC0-A nrPDB Length = 292 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 54/242 (22%), Positives = 102/242 (42%), Gaps = 50/242 (20%) Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH----EKLGEDRIQFLVYQML 138 H N+ G+++V + T Y+ F D G + + ++L E+ L Q++ Sbjct: 57 HSNITGIVEVILGE------TKAYV---FFEKDFGDMHSYVRSRKRLREEEAARLFKQIV 107 Query: 139 KGLRYIHAAGIIHRDLKPGNL--AVNEDCELKIL---DFGLARQADSEMTGYVVTRWYRA 193 + + H + I+ DLK + E +L++ D + + D ++ Y + Sbjct: 108 SAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVS 167 Query: 194 PEVILNWMRYT-QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 PE++ Y+ + D+WS+G ++ ++ G+ F SD P A F + Sbjct: 168 PEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSD--------------PSALFSK- 212 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + + F I + SP A L+ +L + +R+TA E L HP+FE Sbjct: 213 ---------------IRRGQFC-IPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 Query: 313 SL 314 S+ Sbjct: 257 SV 258 >1U54-B nrPDB Length = 291 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 91/209 (43%), Gaps = 25/209 (11%) Query: 28 RDLQPVGSGAYGAV----CSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMR 82 R L+ +G G++G V A G+T VA+K L S+ A + RE+ + + Sbjct: 21 RLLEKLGDGSFGVVRRGEWDAPSGKT-VSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLD 79 Query: 83 HENVIGLLDV-FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQML 138 H N+I L V TP + + +G+ L +L KH+ LG + Q+ Sbjct: 80 HRNLIRLYGVVLTPPMKM------VTELAPLGSLLDRLRKHQGHFLLGT--LSRYAVQVA 131 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV------VTRWYR 192 +G+ Y+ + IHRDL NL + +KI DFGL R YV V + Sbjct: 132 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 191 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMIT 221 APE L ++ D W G + EM T Sbjct: 192 APES-LKTRTFSHASDTWMFGVTLWEMFT 219 >2Y4I-B nrPDB Length = 319 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 96/213 (45%), Gaps = 27/213 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G G +G V GR +VAI+ + +E K RE+ + RHENV+ + Sbjct: 41 IGKGRFGQV---YHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYIHAAGII 150 L T G L +++ K L ++ + + +++KG+ Y+HA GI+ Sbjct: 98 CMSPPHLAIITSLC-----KGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL 152 Query: 151 HRDLKPGNLAVNEDCELKILDFGLARQADSEMTG------YVVTRW--YRAPEVILNW-- 200 H+DLK N+ ++ ++ I DFGL + G + W + APE+I Sbjct: 153 HKDLKSKNV-FYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSP 211 Query: 201 ------MRYTQTVDIWSVGCIMAEMITGKTLFK 227 + +++ D++++G I E+ + FK Sbjct: 212 DTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >5E8V-A nrPDB Length = 316 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 80/166 (48%), Gaps = 28/166 (16%) Query: 80 HMRHENVIGLLDVFTPDETLDDF-TDFYLVMPFMGT-DLGKLMKHEKLGEDRIQFLVYQM 137 +++HEN++ L T +E + ++L+ F +L + + + + ++ L + Sbjct: 65 NLKHENILQFL---TAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSL 121 Query: 138 LKGLRYIHA---------AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM------ 182 +G+ ++H+ I+HRDLK N+ V D + DFGL+ + D + Sbjct: 122 ARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 181 Query: 183 -TGYVVTRWYRAPEVILNWMR------YTQTVDIWSVGCIMAEMIT 221 +G V T Y APEV+ + M + QT D++S+ ++ EM + Sbjct: 182 NSGQVGTARYMAPEVLASAMNLENVESFKQT-DVYSMALVLWEMTS 226 >5J0A-A nrPDB Length = 300 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 25/194 (12%) Query: 47 GRTGAKVAIKKLYRPFQSE----LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDF 102 G + + A+KK+ P ++ ++ KR E ++LK + H N++G FT E D Sbjct: 34 GLSHSPWAVKKI-NPICNDHYRSVYQKRLMDEAKILKSLHHPNIVG-YRAFT--EANDG- 88 Query: 103 TDFYLVMPFMG-TDLGKLMKHE-KLGEDR-----IQFLVYQMLKGLRYIHA-AGIIHRDL 154 L M + G L L++ K +D I + M +GL+Y+H ++H D+ Sbjct: 89 -SLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDI 147 Query: 155 KPGNLAVNEDCE-LKILDFGLARQADSEM------TGYVVTRWYRAPEVILNWMRYTQTV 207 K N+ + D E +KI D G++ D M Y+ T ++ E + T Sbjct: 148 KSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKA 207 Query: 208 DIWSVGCIMAEMIT 221 DI++ G + EM+T Sbjct: 208 DIFAFGLTLWEMMT 221 >4M69-B nrPDB Length = 283 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 81/168 (48%), Gaps = 14/168 (8%) Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEK-LGEDRI 130 E++ +K N++ + + D+T+ +F +VM + +GT L +L+ EK L Sbjct: 58 EIKTMKKFDSPNILRIFGICI-DQTVKP-PEFSIVMEYCELGT-LRELLDREKDLTMSVR 114 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF-------GLARQADSEMT 183 LV + +GL +H + +HR++ + V ++K+ F ++R A S Sbjct: 115 SLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKA 174 Query: 184 GYVVTRWYRAPEVILN-WMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 + Y +PE + N + Y +I+S G ++ E+ TGK F+G D Sbjct: 175 ERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCD 222 >4CI6-B nrPDB Length = 643 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 52/94 (55%), Gaps = 3/94 (3%) Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE-DCELKILDFGLARQADSEMTGYVVT 188 I+F+ +++L ++ AGI+H D+KPGN+ + E ++D GL ++ + G+ T Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF--T 215 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 ++APE+ + + ++ D++ V + I G Sbjct: 216 ESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEG 249 >2QLU-A nrPDB Length = 314 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 80/175 (45%), Gaps = 27/175 (15%) Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL---MKHEKLG 126 ++ RE+ M+HEN++ + L+ + +L+ F D G L +K + Sbjct: 55 QSEREIFSTPGMKHENLLQFIAAEKRGSNLE--VELWLITAF--HDKGSLTDYLKGNIIT 110 Query: 127 EDRIQFLVYQMLKGLRYIH-----------AAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 + + + M +GL Y+H I HRD K N+ + D + DFGLA Sbjct: 111 WNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA 170 Query: 176 RQAD-----SEMTGYVVTRWYRAPEVILNWMRYTQ----TVDIWSVGCIMAEMIT 221 + + + G V TR Y APEV+ + + + +D++++G ++ E+++ Sbjct: 171 VRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVS 225 >4XLV-A nrPDB Length = 328 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 109/247 (44%), Gaps = 40/247 (16%) Query: 21 WEV-RAVYRDLQPVGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRA--Y 72 WEV R L+ +G G++G V + G +VA+K + +S +R Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN---ESASLRERIEFL 90 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK------- 124 E ++K +V+ LL V + + +VM M DL ++ + Sbjct: 91 NEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKSYLRSLRPEAENNP 144 Query: 125 -----LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR--- 176 ++ IQ + ++ G+ Y++A +HRDL N V D +KI DFG+ R Sbjct: 145 GRPPPTLQEMIQ-MAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 203 Query: 177 QAD---SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHL 232 + D G + RW APE + + + +T + D+WS G ++ E+ + + ++G + Sbjct: 204 ETDYYRKGGKGLLPVRWM-APESLKDGV-FTTSSDMWSFGVVLWEITSLAEQPYQGLSNE 261 Query: 233 DQLKEIM 239 LK +M Sbjct: 262 QVLKFVM 268 >3SV0-A nrPDB Length = 483 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 54/225 (24%), Positives = 97/225 (43%), Gaps = 41/225 (18%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIK----KLYRPFQSELFAKRAYRELRL---LK 79 +R + +GSG++G + + +T +VAIK K P L+ + YR L+ + Sbjct: 9 FRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHP--QLLYESKIYRILQGGTGIP 66 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQM 137 ++R V G +V LVM +G L L KL + L QM Sbjct: 67 NVRWFGVEGDYNV--------------LVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQM 112 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMTGYVVTRWYRAP 194 + + ++H+ +HRD+KP N + ++ I+DFGLA++ T + YR Sbjct: 113 INRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIP--YREN 170 Query: 195 EVILNWMRY-----------TQTVDIWSVGCIMAEMITGKTLFKG 228 + + RY ++ D+ S+G ++ + G ++G Sbjct: 171 KNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQG 215 >3I81-A nrPDB Length = 315 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 59/112 (52%), Gaps = 9/112 (8%) Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR---QAD---SEMTGYVVTR 189 ++ G+ Y++A +HRDL N V ED +KI DFG+ R + D G + R Sbjct: 139 EIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR 198 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK 240 W +PE + + + +T D+WS G ++ E+ T + ++G + L+ +M+ Sbjct: 199 WM-SPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME 248 >3G2F-A nrPDB Length = 336 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 83/306 (27%), Positives = 128/306 (41%), Gaps = 50/306 (16%) Query: 30 LQPVGSGAYGAVC-SAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENVI 87 L+ +G G YGAV ++D R VA+K + Q+ + K YR + M H+N+ Sbjct: 18 LELIGRGRYGAVYKGSLDER---PVAVKVFSFANRQNFINEKNIYR----VPLMEHDNIA 70 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL-GEDRIQF--LVYQMLKGLRYI 144 + V T D ++ LVM + G L K+ L D + L + + +GL Y+ Sbjct: 71 RFI-VGDERVTADGRMEYLLVMEYYPN--GSLCKYLSLHTSDWVSSCRLAHSVTRGLAYL 127 Query: 145 HAA---------GIIHRDLKPGNLAVNEDCELKILDFGLAR-----------QADSEMTG 184 H I HRDL N+ V D I DFGL+ + D+ Sbjct: 128 HTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAIS 187 Query: 185 YVVTRWYRAPEVILNWMRY------TQTVDIWSVGCIMAEMITGKT-LFKGSDHLD-QLK 236 V T Y APEV+ + + VD++++G I E+ T LF G + Q+ Sbjct: 188 EVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMA 247 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 +V P E +Q L S E + PE K++ ++ + +E DA Sbjct: 248 FQTEVGNHPTFEDMQVLVSREKQR--PKFPEAWKENSLAVRS-----LKETIEDCWDQDA 300 Query: 297 EQRVTA 302 E R+TA Sbjct: 301 EARLTA 306 >4F0G-A nrPDB Length = 287 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 96/211 (45%), Gaps = 26/211 (12%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLY---RPFQSELFAK--RAYRELRLLKHMRHENVI 87 +G G +G V + + VAIK L ++E+ K RE+ ++ ++ H N++ Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIV 86 Query: 88 GLLDVF-TPDETLDDFT---DFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 L + P + +F D Y + L K + L+ + G+ Y Sbjct: 87 KLYGLMHNPPRMVMEFVPCGDLYHRL---------LDKAHPIKWSVKLRLMLDIALGIEY 137 Query: 144 IHAAG--IIHRDLKPGNL---AVNEDCEL--KILDFGLARQADSEMTGYVVTRWYRAPEV 196 + I+HRDL+ N+ +++E+ + K+ DFGL++Q+ ++G + + APE Sbjct: 138 MQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPET 197 Query: 197 I-LNWMRYTQTVDIWSVGCIMAEMITGKTLF 226 I YT+ D +S I+ ++TG+ F Sbjct: 198 IGAEEESYTEKADTYSFAMILYTILTGEGPF 228 >5AR8-A nrPDB Length = 326 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 73/157 (46%), Gaps = 16/157 (10%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF---AKRAYRELRLLKHMRHEN 85 DL+ + GA G V SA +VA+K L+ + L K RE +L R Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLH--IHTPLLDSERKDVLREAEILHKARFSY 93 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLK----GL 141 ++ +L + E L T++ MP L +L+ + D L +++L G+ Sbjct: 94 ILPILGICNEPEFLGIVTEY---MP--NGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 148 Query: 142 RYIH--AAGIIHRDLKPGNLAVNEDCELKILDFGLAR 176 Y+H ++H DLK N+ ++ + +KI DFGL++ Sbjct: 149 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >4BTF-A nrPDB Length = 469 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 81/168 (48%), Gaps = 14/168 (8%) Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEK-LGEDRI 130 E++ +K N++ + + D+T+ +F +VM + +GT L +L+ EK L Sbjct: 244 EIKTMKKFDSPNILRIFGICI-DQTVKP-PEFSIVMEYCELGT-LRELLDREKDLTMSVR 300 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF-------GLARQADSEMT 183 LV + +GL +H + +HR++ + V ++K+ F ++R A S Sbjct: 301 SLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKA 360 Query: 184 GYVVTRWYRAPEVILN-WMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 + Y +PE + N + Y +I+S G ++ E+ TGK F+G D Sbjct: 361 ERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCD 408 >5CLR-A nrPDB Length = 451 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/124 (24%), Positives = 60/124 (48%), Gaps = 8/124 (6%) Query: 106 YLVMPFM-GTDLGKLMKHEKLGEDRIQF-----LVYQMLKGLRYIHAAGIIHRDLKPGNL 159 Y++ F+ G DL + L + F ++ + ++ H G+IHRDLKPGN+ Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 160 AVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMA 217 ++ D + ++DFG + T Y APE+ +++ ++Q D++++ + Sbjct: 208 MLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLD 267 Query: 218 EMIT 221 E+ Sbjct: 268 ELFN 271 >1PY5-A nrPDB Length = 326 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 96/218 (44%), Gaps = 44/218 (20%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA----YRELRLLKH--MRHE 84 + +G G +G V G +VA+K +F+ R +RE + + +RHE Sbjct: 35 ESIGKGRFGEVWRG--KWRGEEVAVK---------IFSSREERSWFREAEIYQTVMLRHE 83 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++G + D +T +LV + G+ L ++ E I+ L GL Sbjct: 84 NILGFIAADNKDN--GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK-LALSTASGLA 140 Query: 143 YIHAA--------GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM-------TGYVV 187 ++H I HRDLK N+ V ++ I D GLA + DS V Sbjct: 141 HLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVG 200 Query: 188 TRWYRAPEVI---LNWMRYTQT---VDIWSVGCIMAEM 219 T+ Y APEV+ +N M++ ++ DI+++G + E+ Sbjct: 201 TKRYMAPEVLDDSIN-MKHFESFKRADIYAMGLVFWEI 237 >4XHH-A nrPDB Length = 403 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 72/157 (45%), Gaps = 16/157 (10%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIK-KLYRPFQSELFAKRAYRELRLLKHMRHEN 85 +R + +GSG++G + + +G +VAI+ + R +L E R+ K++ Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDY-----ESRVYKYLSGGV 63 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRY 143 I + F + + +V+ +G L L H K + L QM+ ++Y Sbjct: 64 GIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQY 118 Query: 144 IHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQ 177 IH IHRD+KP N + + ++DFGL+++ Sbjct: 119 IHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKK 155 >4L68-A nrPDB Length = 340 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 98/220 (44%), Gaps = 40/220 (18%) Query: 50 GAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLV 108 G+ +A+K L + +R +R E+ L +RH N+ LL +E + +LV Sbjct: 64 GSALAVKHL----STCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEE------EKFLV 113 Query: 109 MPFMGTDLGKLMKHEKLGEDRIQF-------LVYQMLKGLRYIHAAG---IIHRDLKPGN 158 +M G L H L +R + + +GL ++H I+H+++ Sbjct: 114 YKYMSN--GTL--HSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSV 169 Query: 159 LAVNEDCELKILDFGLAR-------QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWS 211 + ++ED + +I+D GLAR S MTG + Y APE M + D++ Sbjct: 170 ILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTT-MLASLKGDVYG 228 Query: 212 VGCIMAEMITGKTL-----FKGS--DHLDQLKEIMKVTGT 244 +G ++ E+ TG FKGS D + QL+ ++ T Sbjct: 229 LGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAET 268 >3MY0-A nrPDB Length = 305 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 91/222 (40%), Gaps = 33/222 (14%) Query: 30 LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 ++ VG G YG V + G VA+K + F + LL RH+N++G Sbjct: 13 VECVGKGRYGEVWRGL--WHGESVAVKIFSSRDEQSWFRETEIYNTVLL---RHDNILGF 67 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA-- 146 + + + + T +L+ + L ++ + L L GL ++H Sbjct: 68 --IASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI 125 Query: 147 ------AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY--------VVTRWYR 192 I HRD K N+ V + + I D GLA S+ + Y V T+ Y Sbjct: 126 FGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVM-HSQGSDYLDIGNNPRVGTKRYM 184 Query: 193 APEVILNWMR------YTQTVDIWSVGCIMAEMITGKTLFKG 228 APEV+ +R Y T DIW+ G ++ E I +T+ G Sbjct: 185 APEVLDEQIRTDCFESYKWT-DIWAFGLVLWE-IARRTIVNG 224 >4XHL-A nrPDB Length = 394 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 72/160 (45%), Gaps = 22/160 (13%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIK-KLYRPFQSEL-FAKRAYRELRLLKHMRHE 84 +R + +GSG++G + + +G +VAI+ + R +L + R YR L Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYL--------S 60 Query: 85 NVIGL--LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 +G+ + F + + +V+ +G L L H + + L QM Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 141 LRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQ 177 ++YIH IHRD+KP N + + ++DFGL+++ Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKK 155 >4TN6-A nrPDB Length = 318 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 44/160 (27%), Positives = 71/160 (44%), Gaps = 22/160 (13%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIK----KLYRPFQSELFAKRAYRELRLLKHMR 82 YR + +GSG++G + D G +VAIK K P + + E ++ K M Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHP--------QLHIESKIYKMM- 59 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 + +G+ + D +VM +G L L K + L QM+ Sbjct: 60 -QGGVGIPTIRWCGAEGDYNV---MVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 141 LRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQ 177 + YIH+ IHRD+KP N + + + I+DFGLA++ Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKK 155 >2C47-A nrPDB Length = 313 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 70/322 (21%), Positives = 128/322 (39%), Gaps = 39/322 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 +R + +G G +G + + T VAIK P +S A + + E R K + Sbjct: 6 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLSATEG 61 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL--MKHEKLGEDRIQFLVYQMLKGLRYI 144 + + F P + +V+ +G L L + + + Q++ + Y+ Sbjct: 62 VPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYV 116 Query: 145 HAAGIIHRDLKPGNLAVN-----EDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVIL 198 H +I+RD+KP N V + I+DFGLA++ D E ++ R +++ Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTA 176 Query: 199 NWMRYTQTV--------DIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG-----TP 245 +M + D+ ++G + + G ++G D LKE + G TP Sbjct: 177 RYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATP 235 Query: 246 PAEFVQRLQSDEAK--NYMKGLPELEKKDFASILTNASPLAVNLLEKM-LVLDAEQRVTA 302 + + A Y++ L EK D+ + L +L ++ V D E A Sbjct: 236 IEVLCENFPEEMATYLRYVRRLDFFEKPDYDYL----RKLFTDLFDRSGFVFDYEYD-WA 290 Query: 303 GEALAHPYFESLHDTEDEPQVQ 324 G+ L P D +PQ++ Sbjct: 291 GKPLPTPIGTVHTDLPSQPQLR 312 >2CMW-A nrPDB Length = 310 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 78/182 (42%), Gaps = 26/182 (14%) Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELK-----ILDFGLARQ-ADSEMT 183 + + Q+L + Y+H+ +I+RD+KP N + K I+DFGLA++ D E Sbjct: 99 VLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETK 158 Query: 184 GYVVTRWYRAPEVILNWMRYTQTV--------DIWSVGCIMAEMITGKTLFKGSDHLDQL 235 ++ R +++ +M + D+ ++G + + G ++G D L Sbjct: 159 KHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK-ADTL 217 Query: 236 KEIMKVTG-----TPPAEFVQRLQSDEAK--NYMKGLPELEKKDFASILTNASPLAVNLL 288 KE + G TP + + A Y++ L EK D+ + T L +L Sbjct: 218 KERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRT----LFTDLF 273 Query: 289 EK 290 EK Sbjct: 274 EK 275 >4IX6-A nrPDB Length = 350 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/204 (21%), Positives = 82/204 (40%), Gaps = 40/204 (19%) Query: 136 QMLKGLRYIHAAGIIHRDLKPGNL--AVNEDCELKILDFGLARQADS--------EMTGY 185 ++L L +H G++HRD+KP NL A + LK++D G A G Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGDGP 210 Query: 186 VVTRWYRAPEVIL-----------NWMRYTQT-----VDIWSVGCIMAEMITGKTLFKGS 229 R+ +A E+ L N + + D WS GC+M ++ + Sbjct: 211 ADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAV--VGLRTD 268 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 L++ K G V + +++ Y DFA++ N +L + Sbjct: 269 AGLERFLADYKAVGYD----VNAFRGEKSGEY-------GTMDFAALDANGGA-GWDLCQ 316 Query: 290 KMLVLDAEQRVTAGEALAHPYFES 313 +++ + + R + AL+H +F++ Sbjct: 317 RLMEAERDARASCEAALSHAFFDA 340 >2CHL-A nrPDB Length = 351 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/175 (22%), Positives = 76/175 (43%), Gaps = 17/175 (9%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 +R + +G G +G + + T VAIK P +S A + + E R K + + Sbjct: 32 FRVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPMKSR--APQLHLEYRFYKQLGSGDG 87 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL--MKHEKLGEDRIQFLVYQMLKGLRYI 144 I + F P + +V+ +G L L + + + Q++ + Y+ Sbjct: 88 IPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYV 142 Query: 145 HAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQ-ADSEMTGYVVTRWYRA 193 H+ +I+RD+KP N + + I+DF LA++ D E ++ R +++ Sbjct: 143 HSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKS 197 >5VDK-A nrPDB Length = 297 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/148 (20%), Positives = 60/148 (40%), Gaps = 5/148 (3%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL- 75 T A + +++ +G G +G V + G AIK+ + F A E+ Sbjct: 7 TNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVY 66 Query: 76 --RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL 133 +L H H +V+ + D+ + ++ E +++ + Sbjct: 67 AHAVLGH--HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDI 124 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 + Q+ GL YIH + ++H D+KP N+ + Sbjct: 125 LLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >5OAT-A nrPDB Length = 411 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 20/117 (17%) Query: 139 KGLRYIHAAGIIHRDLKPGNLAVN----EDCELKILDFGLARQADSEMTGYVVTRW---- 190 +G+ ++ A GI HRDLK NL ++ E L I DFG + T + Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDK 223 Query: 191 -----YRAPEVI------LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 APE+I + + Y++ D+W+VG I E+ F G L Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNYSK-ADLWAVGAIAYEIFNCHNPFYGPSRLKNFN 279 >3DAH-A nrPDB Length = 319 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 47/92 (51%), Gaps = 4/92 (4%) Query: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTNA 280 G +F G+ + +E++K+ G P + V R E + ++ + KD + + Sbjct: 7 GLMVFTGNANPALAQEVVKILGIPLGKAMVSRFSDGEIQVEIQ--ENVRGKDVFVLQSTC 64 Query: 281 SPLAVNLLEKMLVLDAEQRVTAGEALAH-PYF 311 +P NL+E M+++DA +R +AG A PYF Sbjct: 65 APTNDNLMELMIMVDALKRASAGRITAAIPYF 96 >5X18-A nrPDB Length = 295 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 70/158 (44%), Gaps = 16/158 (10%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Y+ + +G G++G + + G VAIK + P ++E A + E + K + Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIK--FEPRKTE--APQLRDEYKTYKILNGTPN 64 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRYI 144 I F E L + LV+ +G L L K + + QM+ + + Sbjct: 65 IPYAYYFG-QEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDL 119 Query: 145 HAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQ 177 HA +I+RD+KP N + + + ++DFG+A+Q Sbjct: 120 HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQ 157 >1CSN-A nrPDB Length = 298 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 70/159 (44%), Gaps = 20/159 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-AYRELRLLKHMRHEN 85 Y+ + +G G++G + + +VAIK + P +S+ R YR +LL Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIK--FEPRRSDAPQLRDEYRTYKLLA-----G 64 Query: 86 VIGLLDVFT-PDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLR 142 G+ +V+ E L + LV+ +G L L+ K + QML ++ Sbjct: 65 CTGIPNVYYFGQEGLHNV----LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQ 120 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLAR 176 IH +++RD+KP N + + ++DFG+ + Sbjct: 121 SIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 >4NT4-A nrPDB Length = 312 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 7/78 (8%) Query: 107 LVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED 164 +V+ +G L L K + + Q+L + Y+H+ +I+RD+KP N + Sbjct: 91 MVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRT 150 Query: 165 CE-----LKILDFGLARQ 177 + I+DFGLA++ Sbjct: 151 STKREKIIHIIDFGLAKE 168 >6G4J-A nrPDB Length = 315 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 5/121 (4%) Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV-NEDCELKILDFGLARQADSEMTG 184 G + I L+ Q+L L +H G I DLKP NL V ++ +D G + + Sbjct: 121 GAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKE 180 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 Y T +Y + + D+++V IM + K K + +QL+ + + G Sbjct: 181 Y--TEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSL--IEGN 236 Query: 245 P 245 P Sbjct: 237 P 237 >6BFN-A nrPDB Length = 342 Score = 36.6 bits (83), Expect = 0.018, Method: Compositional matrix adjust. Identities = 52/225 (23%), Positives = 88/225 (39%), Gaps = 47/225 (20%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA-KRAY-RELRLLKHMRHENVIGLL 90 +G G +G V AV T A+K+L E A K+++ E+ L RH N++ Sbjct: 30 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIV--- 84 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQF---------------LVY 135 DF + F G L EDR+ ++ Sbjct: 85 ----------DFAGYCAQNGFYCLVYGFLPNGSL--EDRLHCQTQACPPLSWPQRLDILL 132 Query: 136 QMLKGLRYIH--AAGIIHRDLKPGNLAVNEDCELKILDFGLAR------QADSEMTGYVV 187 + ++++H + +IH D+K N+ ++E K+ DFGLAR + S+ + Sbjct: 133 GTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVAR 192 Query: 188 TRWYRA-----PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK 227 T+ R PE + R D +S G ++ E + G+ K Sbjct: 193 TQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVK 237 >6EWX-A nrPDB Length = 484 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 16/33 (48%), Positives = 21/33 (63%) Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL 159 E R+ FL+ Q+ GL ++ GIIHRDL NL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 241 >5VE6-A nrPDB Length = 492 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 16/33 (48%), Positives = 21/33 (63%) Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL 159 E R+ FL+ Q+ GL ++ GIIHRDL NL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENL 239 >5M07-A nrPDB Length = 276 Score = 35.0 bits (79), Expect = 0.057, Method: Compositional matrix adjust. Identities = 16/49 (32%), Positives = 26/49 (53%), Gaps = 4/49 (8%) Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE----DCELKILDFGLARQ 177 +V + L Y H G++HRD+ P N+ + D + + DFG+A Q Sbjct: 137 IVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ 185 >2RSV-A nrPDB Length = 403 Score = 34.7 bits (78), Expect = 0.069, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 40/74 (54%), Gaps = 4/74 (5%) Query: 106 YLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE 163 +++M G+DL K+ + ++ + L ++L L YIH +H D+K NL +N Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 164 DC--ELKILDFGLA 175 ++ ++D+GLA Sbjct: 195 KNPDQVYLVDYGLA 208 >2LAV-A nrPDB Length = 361 Score = 34.3 bits (77), Expect = 0.099, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 40/74 (54%), Gaps = 4/74 (5%) Query: 106 YLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE 163 +++M G+DL K+ + ++ + L ++L L YIH +H D+K NL +N Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 164 DC--ELKILDFGLA 175 ++ ++D+GLA Sbjct: 188 KNPDQVYLVDYGLA 201 >6EQI-C nrPDB Length = 433 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 45/111 (40%), Gaps = 27/111 (24%) Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNED-----CELKILDFGLA------------RQADSE 181 + + +++ I HRDLK N+ V+ + I DFG R D + Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 182 MTGYVVTRWYRAPEV------ILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226 G R APE+ +W+ Y ++ D+W+VG I E+ F Sbjct: 238 KGG---NRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPF 284 >5UU1-A nrPDB Length = 324 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 5/74 (6%) Query: 106 YLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV--- 161 ++VM +G DL K+ ++ + + L +ML L YIH +H D+K NL + Sbjct: 107 FMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYK 166 Query: 162 NEDCELKILDFGLA 175 N D ++ + D+GL+ Sbjct: 167 NPD-QVYLADYGLS 179 >6J6I-B nrPDB Length = 351 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 49/102 (48%), Gaps = 21/102 (20%) Query: 136 QMLKGLRYIHAAG---IIHRDLKPGNLAVNEDCELKILDFGLA-------RQADSEMT-- 183 ++ + Y+H A IIHRD+KP ++ ++++ K+ D + + ++E Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLG 230 Query: 184 --GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 GY+ +++ V T+ D++S G + +ITGK Sbjct: 231 TFGYIDPLYHKTCFV-------TEYTDVYSFGICLLVIITGK 265 >4BWP-A nrPDB Length = 448 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 34/149 (22%) Query: 44 AVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTP----DETL 99 A TG K +++++ L + + + + K ++H NV+ L +VFT D +L Sbjct: 69 ATHNTTGYKYCLRRIH---GFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSL 125 Query: 100 DDFTDFY-------------------LVMPFMG--------TDLGKLMKHEKLGEDRIQF 132 D++ PF G +++ + L E I Sbjct: 126 VLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWS 185 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 ++ Q+ GL+ IH AG+ + L P + V Sbjct: 186 IIMQLTAGLKAIHHAGLACKVLDPTKIIV 214 >3Q60-A nrPDB Length = 371 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 29/126 (23%), Positives = 50/126 (39%), Gaps = 13/126 (10%) Query: 100 DDFT--DFYLVMPFMGTDLGKLMKHEKL-----GEDRI---QFLVYQMLKGLRYIHAAGI 149 DD+ ++ L+MP DL L G++ I L Q+++ + + G+ Sbjct: 156 DDYAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGL 215 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILN--WMRYTQTV 207 +H P NL + D L + D + + V Y AP LN +T + Sbjct: 216 VHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTY-APREFLNASTATFTHAL 274 Query: 208 DIWSVG 213 + W +G Sbjct: 275 NAWQLG 280 >3MOY-A nrPDB Length = 263 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 44/111 (39%), Gaps = 23/111 (20%) Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRA 193 Y + R + G+I D A+N+ E ++LD AD E+ VVT RA Sbjct: 7 TYTTIATSRPVAGVGLIRLDRPDALNALNQTLEAEVLDAARDFDADLEIGAIVVTGSERA 66 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT-------GKTLFKGSDHLDQLKE 237 ++ G +AEM+T + L G D L Q+++ Sbjct: 67 ----------------FAAGADIAEMVTLTPHQARERNLLSGWDSLTQVRK 101 >5YK0-A nrPDB Length = 452 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 11/26 (42%), Positives = 16/26 (61%) Query: 148 GIIHRDLKPGNLAVNEDCELKILDFG 173 G++H D PGN + D + I+DFG Sbjct: 286 GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6H8K-C nrPDB Length = 383 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 26/43 (60%), Gaps = 1/43 (2%) Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 E K YM+ LP ++ D+ S++TN ++ +EK+L ++ R Sbjct: 46 EYKTYMQALPYFDRLDYVSMMTNEQVFSLA-VEKLLNVEVPLR 87 >2JJD-A nrPDB Length = 599 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 3/62 (4%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE--LFAKRAYRELRLLK- 79 + AV + Q G+ CSA GRTG +A+ + ++E L +A + LRL + Sbjct: 506 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 565 Query: 80 HM 81 HM Sbjct: 566 HM 567 >6GCS-C nrPDB Length = 466 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 26/43 (60%), Gaps = 1/43 (2%) Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 E K YM+ LP ++ D+ S++TN ++ +EK+L ++ R Sbjct: 128 EYKTYMQALPYFDRLDYVSMMTNEQVFSLA-VEKLLNVEVPLR 169 >6D3F-A nrPDB Length = 279 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 3/62 (4%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE--LFAKRAYRELRLLK- 79 + AV + Q G+ CSA GRTG +A+ + ++E L +A + LRL + Sbjct: 190 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 249 Query: 80 HM 81 HM Sbjct: 250 HM 251 >4AZV-A nrPDB Length = 569 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 11/37 (29%), Positives = 21/37 (56%) Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 +L+ L + G H D++P N+ V+ +++DFG Sbjct: 348 LLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 28.5 bits (62), Expect = 5.0, Method: Compositional matrix adjust. Identities = 11/37 (29%), Positives = 21/37 (56%) Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 +L+ L + G H D++P N+ V+ +++DFG Sbjct: 348 LLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >2QM3-A nrPDB Length = 373 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 17/147 (11%) Query: 229 SDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN----YMKGLPELEKKDFASI----LTNA 280 +D L+Q +EI+K P EF Q + E M +LE KD + LT+ Sbjct: 128 ADLLEQFREIVKDRPEPLHEFDQAYVTPETTVARVILMHTRGDLENKDIFVLGDDDLTSI 187 Query: 281 SPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYFESLHDTEDEP----QVQKYDDSFD 331 + + L +++ VLD ++R+T A + + E +P + K+D Sbjct: 188 ALMLSGLPKRIAVLDIDERLTKFIEKAANEIGYEDIEIFTFDLRKPLPDYALHKFDTFIT 247 Query: 332 DVDRTLDEWKRVTYKEVLSFKPPRQLG 358 D TL+ + + + + K PR G Sbjct: 248 DPPETLEAIRAFVGRGIATLKGPRCAG 274 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1CM8-A nrPDB 541 e-154 4EWQ-A nrPDB 455 e-128 3OHT-A nrPDB 452 e-127 3GC9-A nrPDB 436 e-123 4MYG-A nrPDB 429 e-121 1JNK-A nrPDB 392 e-109 2XS0-A nrPDB 389 e-108 5AWM-A nrPDB 382 e-106 6DTL-A nrPDB 373 e-104 3E7O-A nrPDB 370 e-103 4QTB-A nrPDB 365 e-101 5Z33-A nrPDB 364 e-101 4IC8-A nrPDB 362 e-100 5NGU-A nrPDB 361 e-100 4ZSG-A nrPDB 359 1e-99 3FI2-A nrPDB 356 9e-99 2F9G-A nrPDB 356 1e-98 4QNY-A nrPDB 337 4e-93 4O2Z-A nrPDB 334 4e-92 3OZ6-A nrPDB 333 5e-92 2BPM-A nrPDB 332 2e-91 3RP9-A nrPDB 331 3e-91 3NIZ-A nrPDB 319 1e-87 3N9X-A nrPDB 315 2e-86 6GU6-A nrPDB 314 4e-86 3NIE-A nrPDB 313 6e-86 3PG1-A nrPDB 307 5e-84 1V0B-A nrPDB 304 5e-83 4KRC-A nrPDB 303 8e-83 5EFQ-A nrPDB 301 3e-82 4AU8-A nrPDB 300 7e-82 4NST-A nrPDB 299 1e-81 3LIJ-A nrPDB 293 7e-80 4AGU-A nrPDB 293 8e-80 3NCG-A nrPDB 291 3e-79 5JN2-A nrPDB 290 7e-79 3DFA-A nrPDB 290 8e-79 2I6L-A nrPDB 289 1e-78 1UA2-A nrPDB 289 1e-78 4BBM-A nrPDB 287 4e-78 1G3N-A nrPDB 287 5e-78 3MIA-A nrPDB 285 2e-77 4MVF-A nrPDB 285 2e-77 3DXN-A nrPDB 284 3e-77 3MA6-A nrPDB 284 4e-77 5AIR-A nrPDB 284 6e-77 3HZT-A nrPDB 283 7e-77 5G6V-A nrPDB 280 6e-76 4E7W-A nrPDB 280 7e-76 2W96-B nrPDB 279 1e-75 2VN9-A nrPDB 278 3e-75 5U6Y-A nrPDB 277 7e-75 5FG8-A nrPDB 277 7e-75 2VZ6-A nrPDB 276 8e-75 2V7O-A nrPDB 276 8e-75 3Q5I-A nrPDB 274 6e-74 3BHH-A nrPDB 272 1e-73 5ES1-A nrPDB 272 1e-73 2BDW-A nrPDB 271 3e-73 4YZB-A nrPDB 271 4e-73 5IG1-A nrPDB 271 5e-73 4RGJ-A nrPDB 270 6e-73 3SOA-A nrPDB 270 6e-73 4FG9-A nrPDB 269 1e-72 2QNJ-A nrPDB 269 1e-72 3MN3-A nrPDB 269 1e-72 3KK8-A nrPDB 268 2e-72 4BGQ-A nrPDB 268 2e-72 5Y86-A nrPDB 268 3e-72 4CZT-A nrPDB 267 4e-72 5KZ7-A nrPDB 267 5e-72 5YKS-A nrPDB 267 5e-72 3GC0-A nrPDB 267 6e-72 4NIF-A nrPDB 265 2e-71 2JC6-A nrPDB 265 2e-71 3UTO-A nrPDB 264 4e-71 2YCR-A nrPDB 264 5e-71 4CFF-A nrPDB 263 8e-71 3H4J-B nrPDB 263 1e-70 5XZW-A nrPDB 262 1e-70 5EZV-A nrPDB 262 1e-70 3COM-A nrPDB 262 1e-70 3ZDU-A nrPDB 262 2e-70 1KOA-A nrPDB 262 2e-70 5KCV-A nrPDB 260 6e-70 5ZTN-A nrPDB 260 7e-70 4REW-A nrPDB 259 1e-69 5WAX-A nrPDB 259 1e-69 3D2K-A nrPDB 259 1e-69 4JG6-A nrPDB 259 1e-69 2JAM-A nrPDB 259 2e-69 4L42-A nrPDB 259 2e-69 4PDS-A nrPDB 258 2e-69 3I6U-A nrPDB 258 3e-69 4CQG-A nrPDB 258 4e-69 3EB0-A nrPDB 257 4e-69 4D2V-A nrPDB 257 6e-69 4UZD-A nrPDB 256 1e-68 3F3Z-A nrPDB 256 1e-68 2J90-A nrPDB 256 1e-68 6FD3-A nrPDB 256 1e-68 4LG4-A nrPDB 256 2e-68 4RED-A nrPDB 255 2e-68 3MV5-A nrPDB 255 3e-68 2HAK-A nrPDB 255 3e-68 4CFH-A nrPDB 255 3e-68 3TAC-A nrPDB 254 4e-68 6C9D-A nrPDB 254 4e-68 6AO5-A nrPDB 253 1e-67 2HW6-A nrPDB 253 1e-67 3E3P-A nrPDB 252 1e-67 2Y7J-A nrPDB 251 3e-67 5JZN-A nrPDB 251 3e-67 3GUB-A nrPDB 251 4e-67 3ZUT-A nrPDB 251 5e-67 2YZA-A nrPDB 250 6e-67 2YAB-A nrPDB 250 8e-67 3UC3-A nrPDB 250 9e-67 1PHK-A nrPDB 249 1e-66 4D28-A nrPDB 249 1e-66 2JDO-A nrPDB 249 1e-66 5D7A-A nrPDB 248 2e-66 3UDB-A nrPDB 247 4e-66 4RLP-A nrPDB 247 6e-66 2A27-A nrPDB 246 9e-66 2F57-A nrPDB 246 1e-65 3IS5-A nrPDB 246 2e-65 1ZWS-A nrPDB 246 2e-65 6CKI-A nrPDB 245 2e-65 3Q53-A nrPDB 245 3e-65 2W4O-A nrPDB 245 3e-65 4FIE-A nrPDB 245 3e-65 4KS7-A nrPDB 245 3e-65 4JDH-A nrPDB 244 4e-65 4XBR-A nrPDB 244 4e-65 2Q0N-A nrPDB 244 4e-65 1FOT-A nrPDB 244 7e-65 3DAK-A nrPDB 244 7e-65 1KOB-A nrPDB 244 7e-65 5D9K-A nrPDB 243 7e-65 4JXF-A nrPDB 243 9e-65 4QMW-A nrPDB 243 1e-64 6FYV-A nrPDB 240 6e-64 2Z7Q-A nrPDB 240 7e-64 3TXO-A nrPDB 240 1e-63 2UV2-A nrPDB 239 1e-63 4B6L-A nrPDB 239 1e-63 2X4F-A nrPDB 238 3e-63 6FDY-U nrPDB 238 3e-63 5X8I-B nrPDB 238 4e-63 3HDN-A nrPDB 237 5e-63 4U41-A nrPDB 237 6e-63 3HKO-A nrPDB 236 1e-62 5DBX-A nrPDB 236 1e-62 2XIK-A nrPDB 236 2e-62 4YNZ-A nrPDB 235 2e-62 6CMJ-A nrPDB 235 2e-62 4FZF-B nrPDB 235 2e-62 5X3F-B nrPDB 235 2e-62 6O6Q-A nrPDB 234 4e-62 5J5T-A nrPDB 234 5e-62 3ORZ-A nrPDB 234 6e-62 3DB8-A nrPDB 233 8e-62 3KN6-A nrPDB 233 1e-61 4WB7-A nrPDB 232 1e-61 3NYO-A nrPDB 232 2e-61 4CSV-A nrPDB 231 3e-61 1U5R-A nrPDB 231 4e-61 3LM0-A nrPDB 231 4e-61 2WO6-A nrPDB 230 5e-61 2OU7-A nrPDB 230 5e-61 4I6B-A nrPDB 230 8e-61 5YV8-A nrPDB 230 8e-61 2GCD-A nrPDB 230 9e-61 4J52-A nrPDB 230 9e-61 1VZO-A nrPDB 229 2e-60 5F9E-A nrPDB 229 2e-60 5N23-A nrPDB 229 2e-60 4B8L-A nrPDB 229 2e-60 6HXF-B nrPDB 228 3e-60 5LOH-A nrPDB 227 4e-60 4AF3-A nrPDB 227 9e-60 6CQF-A nrPDB 226 1e-59 5UNP-A nrPDB 226 1e-59 6E9W-A nrPDB 226 1e-59 6ED6-A nrPDB 225 2e-59 5XVU-A nrPDB 225 2e-59 3RAW-A nrPDB 224 4e-59 4APC-A nrPDB 224 4e-59 3TKU-A nrPDB 223 8e-59 4C0T-A nrPDB 223 1e-58 3FXW-A nrPDB 222 1e-58 3VN9-A nrPDB 222 1e-58 4MD7-E nrPDB 222 1e-58 2PVN-A nrPDB 222 2e-58 6HMD-A nrPDB 221 3e-58 5DYK-A nrPDB 221 4e-58 4WNO-A nrPDB 221 5e-58 1NY3-A nrPDB 220 7e-58 6QAU-A nrPDB 220 7e-58 4AW2-A nrPDB 220 7e-58 5FET-A nrPDB 219 1e-57 4RA4-A nrPDB 219 1e-57 2OZA-A nrPDB 219 1e-57 3KA0-A nrPDB 219 2e-57 3A8W-A nrPDB 217 5e-57 2H8H-A nrPDB 217 5e-57 4TNB-A nrPDB 217 6e-57 6F3F-A nrPDB 217 8e-57 6EII-A nrPDB 216 1e-56 4CRL-A nrPDB 216 1e-56 3ALO-A nrPDB 216 2e-56 6E2O-A nrPDB 214 4e-56 5MJB-A nrPDB 214 4e-56 2WQN-A nrPDB 213 9e-56 5SYS-A nrPDB 213 1e-55 4XEY-B nrPDB 212 1e-55 2FO0-A nrPDB 212 1e-55 2BRG-A nrPDB 212 2e-55 2WTK-C nrPDB 212 2e-55 6BDL-A nrPDB 211 3e-55 6CCF-A nrPDB 211 5e-55 3PPZ-A nrPDB 210 7e-55 3FME-A nrPDB 210 7e-55 5L6P-A nrPDB 210 8e-55 2XYN-A nrPDB 210 1e-54 4IAN-A nrPDB 209 1e-54 5KKR-C nrPDB 209 1e-54 3PFQ-A nrPDB 209 2e-54 6NPU-A nrPDB 209 2e-54 4FR4-A nrPDB 209 2e-54 2VD5-A nrPDB 209 2e-54 2DQ7-X nrPDB 208 3e-54 2XNP-A nrPDB 208 4e-54 3EQC-A nrPDB 208 4e-54 2Y6O-A nrPDB 208 4e-54 4OLI-A nrPDB 207 4e-54 4GS6-A nrPDB 207 5e-54 2I0E-A nrPDB 207 5e-54 6DBM-A nrPDB 207 7e-54 2JD5-A nrPDB 206 1e-53 4AN9-A nrPDB 206 1e-53 4EBW-A nrPDB 206 1e-53 6GVJ-A nrPDB 206 2e-53 3C51-A nrPDB 205 2e-53 4CRS-A nrPDB 205 2e-53 2VWV-A nrPDB 205 2e-53 4UY9-A nrPDB 205 3e-53 4OTD-A nrPDB 205 3e-53 1JPA-A nrPDB 205 3e-53 1ZXE-A nrPDB 205 3e-53 1K9A-A nrPDB 205 3e-53 2R2P-A nrPDB 204 4e-53 4P5Q-A nrPDB 204 4e-53 5VO2-A nrPDB 204 4e-53 1BYG-A nrPDB 204 6e-53 4KIK-B nrPDB 204 6e-53 4E93-A nrPDB 204 6e-53 5AP3-A nrPDB 204 6e-53 1TKI-A nrPDB 204 8e-53 3DTC-A nrPDB 203 8e-53 4YHJ-A nrPDB 203 8e-53 5O2B-A nrPDB 203 1e-52 1AD5-A nrPDB 203 1e-52 3A4O-X nrPDB 202 1e-52 3HMP-A nrPDB 202 2e-52 4WUA-A nrPDB 202 2e-52 4UYA-A nrPDB 202 2e-52 5UUU-A nrPDB 202 2e-52 2X7G-A nrPDB 202 2e-52 4EQM-A nrPDB 202 3e-52 5O2C-A nrPDB 202 3e-52 3PVW-A nrPDB 201 4e-52 2J0K-A nrPDB 201 4e-52 4PWN-A nrPDB 201 4e-52 6BXI-A nrPDB 201 5e-52 4AT3-A nrPDB 200 6e-52 2W1I-A nrPDB 200 9e-52 2HK5-A nrPDB 200 1e-51 2ZMD-A nrPDB 200 1e-51 3V5Q-A nrPDB 199 1e-51 2PL0-A nrPDB 199 2e-51 5H2U-A nrPDB 199 2e-51 1S9I-A nrPDB 199 2e-51 4E20-A nrPDB 198 3e-51 5X5O-A nrPDB 198 3e-51 3QA8-A nrPDB 198 3e-51 3DKO-A nrPDB 198 3e-51 3ORP-A nrPDB 198 3e-51 3DLS-A nrPDB 197 5e-51 5TQX-A nrPDB 197 5e-51 5HI2-A nrPDB 197 8e-51 6DBN-A nrPDB 196 2e-50 6GQK-A nrPDB 195 2e-50 5A46-A nrPDB 195 2e-50 3OMV-A nrPDB 195 2e-50 3LLT-A nrPDB 195 3e-50 3QGY-A nrPDB 195 3e-50 3TT0-A nrPDB 195 3e-50 5U6B-A nrPDB 194 4e-50 4LFI-A nrPDB 194 4e-50 3QUP-A nrPDB 194 6e-50 3SXS-A nrPDB 194 6e-50 6E4F-A nrPDB 194 7e-50 5KMM-A nrPDB 194 7e-50 4XCU-A nrPDB 193 9e-50 5B2L-A nrPDB 192 2e-49 5UIU-A nrPDB 192 2e-49 4XI2-A nrPDB 192 2e-49 4M7I-A nrPDB 192 2e-49 3M42-A nrPDB 192 2e-49 3GQL-A nrPDB 192 3e-49 4PDO-A nrPDB 192 3e-49 4K33-A nrPDB 192 3e-49 3IO7-A nrPDB 191 3e-49 4C59-A nrPDB 191 4e-49 4Y93-A nrPDB 191 4e-49 5HIE-A nrPDB 191 4e-49 4XLV-A nrPDB 191 5e-49 4H1J-A nrPDB 190 6e-49 2OGV-A nrPDB 190 1e-48 1LUF-A nrPDB 189 2e-48 3KRL-A nrPDB 189 2e-48 4XUF-A nrPDB 189 2e-48 6FEX-A nrPDB 189 2e-48 3BEA-A nrPDB 189 3e-48 2PSQ-A nrPDB 188 3e-48 5GNK-A nrPDB 188 3e-48 4NEU-A nrPDB 188 3e-48 3BBT-B nrPDB 188 4e-48 6B2Q-A nrPDB 188 4e-48 4X3F-A nrPDB 188 4e-48 4OW8-A nrPDB 188 4e-48 5O0Y-A nrPDB 188 4e-48 5X02-A nrPDB 188 4e-48 4HVI-A nrPDB 187 6e-48 3ZBF-A nrPDB 187 6e-48 3LZB-A nrPDB 187 6e-48 1FVR-A nrPDB 187 9e-48 6BSD-A nrPDB 187 9e-48 3BGP-A nrPDB 186 1e-47 5TUR-A nrPDB 186 1e-47 3CJF-A nrPDB 186 1e-47 3KUL-B nrPDB 186 1e-47 5EG3-A nrPDB 185 2e-47 2WTK-B nrPDB 185 3e-47 4HZS-A nrPDB 185 3e-47 4X7Q-B nrPDB 185 3e-47 4RC3-A nrPDB 184 4e-47 4YFF-A nrPDB 184 4e-47 3PP0-A nrPDB 184 6e-47 5VD3-A nrPDB 184 6e-47 5HVK-A nrPDB 184 7e-47 4R7H-A nrPDB 184 8e-47 1U54-B nrPDB 183 1e-46 3G0E-A nrPDB 183 1e-46 5HLW-A nrPDB 182 2e-46 4LRM-A nrPDB 182 2e-46 3C1X-A nrPDB 182 2e-46 5AMN-A nrPDB 182 3e-46 6CTH-A nrPDB 181 5e-46 4Y83-A nrPDB 180 6e-46 2A1A-B nrPDB 180 8e-46 4IDT-A nrPDB 180 9e-46 3PLS-A nrPDB 180 9e-46 5U6C-A nrPDB 180 1e-45 5TOS-A nrPDB 179 2e-45 1U59-A nrPDB 179 2e-45 5GRN-A nrPDB 178 2e-45 4TPT-A nrPDB 178 2e-45 4PL5-B nrPDB 178 3e-45 3I81-A nrPDB 178 5e-45 6FER-A nrPDB 177 6e-45 2RIO-A nrPDB 177 6e-45 6J5U-C nrPDB 177 9e-45 2OZO-A nrPDB 177 9e-45 5FM2-A nrPDB 176 1e-44 3UIU-A nrPDB 176 2e-44 6HV0-A nrPDB 175 2e-44 2BUJ-A nrPDB 174 4e-44 5WNL-A nrPDB 174 6e-44 3Q4U-A nrPDB 172 2e-43 5LPZ-A nrPDB 172 2e-43 5LPV-A nrPDB 172 3e-43 3QD2-B nrPDB 171 3e-43 4F0G-A nrPDB 171 4e-43 4G3E-A nrPDB 170 8e-43 3ZZW-A nrPDB 169 2e-42 2PMN-X nrPDB 167 8e-42 3SOC-A nrPDB 167 9e-42 5TE0-A nrPDB 165 3e-41 3MDY-A nrPDB 165 3e-41 4JLC-A nrPDB 165 3e-41 4FL3-A nrPDB 165 4e-41 4EUU-A nrPDB 164 6e-41 3G2F-A nrPDB 164 6e-41 5WNO-A nrPDB 164 7e-41 4F9B-A nrPDB 163 1e-40 4EUT-A nrPDB 162 2e-40 5C26-A nrPDB 162 2e-40 3UIM-A nrPDB 161 4e-40 1PY5-A nrPDB 161 4e-40 5IKW-A nrPDB 160 6e-40 6O8B-A nrPDB 160 8e-40 6NT9-A nrPDB 160 9e-40 2QKW-B nrPDB 160 1e-39 3MY0-A nrPDB 159 1e-39 5XD6-A nrPDB 158 3e-39 4M66-A nrPDB 158 4e-39 6DC0-A nrPDB 157 8e-39 5CEK-A nrPDB 157 9e-39 2H34-A nrPDB 157 1e-38 5E8V-A nrPDB 156 2e-38 3LMG-A nrPDB 153 8e-38 2Y4I-B nrPDB 153 1e-37 4LQP-A nrPDB 151 4e-37 5AR8-A nrPDB 150 6e-37 2QLU-A nrPDB 148 3e-36 5L2Q-C nrPDB 147 6e-36 5VC6-A nrPDB 146 2e-35 3SV0-A nrPDB 145 2e-35 5J0A-A nrPDB 144 6e-35 4TN6-A nrPDB 143 1e-34 2C47-A nrPDB 143 1e-34 5FQD-C nrPDB 142 4e-34 4BTK-A nrPDB 138 5e-33 4BTF-A nrPDB 137 1e-32 4NFN-A nrPDB 137 1e-32 4M69-B nrPDB 136 1e-32 2CMW-A nrPDB 134 5e-32 4JRN-A nrPDB 132 3e-31 3VHK-A nrPDB 130 7e-31 2PZI-A nrPDB 129 2e-30 4Y12-A nrPDB 129 2e-30 3HNG-A nrPDB 129 2e-30 5X1R-A nrPDB 126 1e-29 4XHH-A nrPDB 126 1e-29 4L68-A nrPDB 125 4e-29 4XHL-A nrPDB 123 8e-29 4RT7-A nrPDB 123 1e-28 5CLR-A nrPDB 100 2e-21 4IX6-A nrPDB 96 2e-20 4CI6-B nrPDB 87 9e-18 Sequences not found previously or not previously below threshold: 3AOX-A nrPDB 167 9e-42 6BFN-A nrPDB 145 3e-35 2CHL-A nrPDB 138 3e-33 5VDK-A nrPDB 133 1e-31 4MWI-A nrPDB 131 4e-31 4NT4-A nrPDB 130 1e-30 5X18-A nrPDB 126 2e-29 1CSN-A nrPDB 114 8e-26 4L00-A nrPDB 110 8e-25 5USZ-A nrPDB 109 2e-24 5M07-A nrPDB 106 1e-23 5OAT-A nrPDB 106 2e-23 6EQI-C nrPDB 105 4e-23 5UV4-A nrPDB 102 3e-22 3REP-A nrPDB 101 3e-22 5C01-A nrPDB 95 5e-20 4WOV-A nrPDB 94 8e-20 4I94-A nrPDB 93 1e-19 6J6I-B nrPDB 91 7e-19 5UU1-A nrPDB 87 1e-17 2RSV-A nrPDB 77 1e-14 2LAV-A nrPDB 77 2e-14 4O1O-A nrPDB 68 6e-12 6G4J-A nrPDB 67 1e-11 2JII-A nrPDB 67 1e-11 5DMZ-A nrPDB 67 2e-11 6M7Z-A nrPDB 65 7e-11 6EAS-A nrPDB 63 2e-10 4OAU-C nrPDB 63 3e-10 5GZA-A nrPDB 62 4e-10 6EWX-A nrPDB 61 7e-10 5GZ9-A nrPDB 61 9e-10 3ENH-A nrPDB 58 9e-09 4AZW-A nrPDB 56 3e-08 4CYJ-A nrPDB 56 3e-08 4AZV-A nrPDB 55 4e-08 4WWA-A nrPDB 55 6e-08 5VE6-A nrPDB 53 2e-07 6BHC-A nrPDB 52 5e-07 6G38-A nrPDB 51 7e-07 3BYV-A nrPDB 51 1e-06 2W1Z-A nrPDB 49 3e-06 3Q60-A nrPDB 48 6e-06 4BWP-A nrPDB 45 4e-05 3DZO-A nrPDB 45 4e-05 4CZY-B nrPDB 45 7e-05 6G5I-z nrPDB 41 0.001 4OTP-A nrPDB 41 0.001 5YK0-A nrPDB 38 0.005 1TQM-A nrPDB 38 0.007 6FAI-l nrPDB 36 0.018 6G18-v nrPDB 36 0.024 6FDN-A nrPDB 35 0.047 4BVU-A nrPDB 35 0.060 1F8S-A nrPDB 33 0.15 6DFL-A nrPDB 33 0.16 3AOI-E nrPDB 33 0.29 >1CM8-A nrPDB Length = 367 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 367/367 (100%), Positives = 367/367 (100%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM Sbjct: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS Sbjct: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK Sbjct: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 Query: 361 VSKETPL 367 VSKETPL Sbjct: 361 VSKETPL 367 >4EWQ-A nrPDB Length = 383 Score = 455 bits (1171), Expect = e-128, Method: Composition-based stats. Identities = 222/354 (62%), Positives = 281/354 (79%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S+ R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RP Sbjct: 22 SNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP 81 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK 121 FQS + AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K Sbjct: 82 FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK 141 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 +KL +D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D E Sbjct: 142 CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 201 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 MTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ Sbjct: 202 MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 261 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 GTP AE ++++ S+ A+NY++ L ++ K +FA++ A+PLAV+LLEKMLVLD+++R+T Sbjct: 262 VGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRIT 321 Query: 302 AGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPR 355 A +ALAH YF HD +DEP YD SF+ D +DEWK +TY EV+SF PP Sbjct: 322 AAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 375 >3OHT-A nrPDB Length = 389 Score = 452 bits (1162), Expect = e-127, Method: Composition-based stats. Identities = 222/352 (63%), Positives = 280/352 (79%) Query: 4 PPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ 63 R FYRQE+ KT WEV Y+ L PVGSGAYG+VCS+ D ++G K+A+KKL RPFQ Sbjct: 30 SHKERPTFYRQELNKTIWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQ 89 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE 123 S + AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K + Sbjct: 90 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQ 149 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 KL +D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMT Sbjct: 150 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 209 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 GYV TRWYRAPE++LNWM Y TVDIWSVGCIMAE++TG+TLF G+DH++QL++IM++TG Sbjct: 210 GYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 269 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 TPPA + R+ S EA+NY+ LP++ K++FA + A+PLAV+LLEKMLVLD ++R+TA Sbjct: 270 TPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITAS 329 Query: 304 EALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPR 355 EALAHPYF HD +DEP+ + YD SF+ ++EWKR+TY+EV SF+ P Sbjct: 330 EALAHPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSFETPP 381 >3GC9-A nrPDB Length = 370 Score = 436 bits (1121), Expect = e-123, Method: Composition-based stats. Identities = 221/351 (62%), Positives = 280/351 (79%), Gaps = 3/351 (0%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS P R+GFYRQE+ KT WEV + L+PVGSGAYG+VCSA D R KVA+KKL R Sbjct: 7 MSGP---RAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSR 63 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQS + A+R YRELRLLKH++HENVIGLLDVFTP +++DF++ YLV MG DL ++ Sbjct: 64 PFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV 123 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 K + L ++ +QFLVYQ+L+GL+YIH+AGIIHRDLKP N+AVNED EL+ILDFGLARQAD Sbjct: 124 KSQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADE 183 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 EMTGYV TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++ GK LF GSD++DQLK IM+ Sbjct: 184 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIME 243 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 V GTP E + ++ S+ A+ Y++ LP + +KD +SI A+PLA++LL +MLVLD++QRV Sbjct: 244 VVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV 303 Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSF 351 +A EALAH YF HD EDEP+ + YD+S + +RTL+EWK +TY+EVLSF Sbjct: 304 SAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF 354 >4MYG-A nrPDB Length = 372 Score = 429 bits (1104), Expect = e-121, Method: Composition-based stats. Identities = 233/347 (67%), Positives = 280/347 (80%), Gaps = 2/347 (0%) Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 + GFY+Q+V KTAWE+ Y VGSGAYG+VCSA+D R+G KVAIKKL RPFQSE+F Sbjct: 26 KKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 AKRAYREL LLKHM+HENVIGLLDVFTP +L +F DFYLVMPFM TDL K+M E E Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSE 144 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 ++IQ+LVYQMLKGL+YIH+AG++HRDLKPGNLAVNEDCELKILDFGLAR AD+EMTGYVV Sbjct: 145 EKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV 204 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 TRWYRAPEVIL+WM Y QTVDIWSVGCIMAEM+TGKTLFKG D+LDQL +I+KVTG P Sbjct: 205 TRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGT 264 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 EFVQ+L AK+Y++ LP+ +KDF + ASP A +LLEKML LD ++R+TA +AL Sbjct: 265 EFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALT 324 Query: 308 HPYFESLHDTEDEPQV-QKYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 HP+FE D E+E + Q +DDS + T+DEWK+ YKE+++F P Sbjct: 325 HPFFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 371 >1JNK-A nrPDB Length = 423 Score = 392 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 170/382 (44%), Positives = 242/382 (63%), Gaps = 20/382 (5%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL R Sbjct: 39 MSKSKVDN-QFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 97 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQ++ AKRAYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L +++ Sbjct: 98 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 157 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 + E L +R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + Sbjct: 158 QME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 216 Query: 181 E--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 MT YVVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++ Sbjct: 217 SFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVN 286 ++ GTP EF+++LQ +NY++ P+ F + ++ + A + Sbjct: 276 IEQLGTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD 334 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVT 344 LL KMLV+D +R++ +AL HPY +D + P Q YD D+ + T++EWK + Sbjct: 335 LLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELI 394 Query: 345 YKEVLSFKPPRQLGARVSKETP 366 YKEV++ + + G + +P Sbjct: 395 YKEVMNSEEKTKNGVVKGQPSP 416 >2XS0-A nrPDB Length = 386 Score = 389 bits (1000), Expect = e-108, Method: Composition-based stats. Identities = 168/383 (43%), Positives = 241/383 (62%), Gaps = 20/383 (5%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS FY E+ + + V Y++L+P+GSGA G VC+A D VAIKKL R Sbjct: 3 MSRSKRDN-NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR 61 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQ++ AKRAYREL L+K + H+N+IGLL+VFTP ++L++F D Y+VM M +L +++ Sbjct: 62 PFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI 121 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 + E L +R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + Sbjct: 122 QME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 180 Query: 181 E--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 M +VVTR+YRAPEVIL M Y + VDIWSVGCIM EMI G LF G+DH+DQ ++ Sbjct: 181 SFMMVPFVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKV 239 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVN 286 ++ GTP EF+++LQ + Y++ P+ F + + + A + Sbjct: 240 IEQLGTPCPEFMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD 298 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVT 344 LL KMLV+DA +R++ EAL HPY +D + P + D D+ + T++EWK + Sbjct: 299 LLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELI 358 Query: 345 YKEVLSFKPPRQLGARVSKETPL 367 YKEV+ + + G + +PL Sbjct: 359 YKEVMDLEERTKNGVIRGQPSPL 381 >5AWM-A nrPDB Length = 394 Score = 382 bits (982), Expect = e-106, Method: Composition-based stats. Identities = 173/372 (46%), Positives = 235/372 (63%), Gaps = 20/372 (5%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 A+ Y EV T + + + Y +L+P+GSGA G VC+A D T VAIKKL RPFQ+ Sbjct: 26 AQHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVT 85 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126 AKRAYRE +L+K + H+N+IGLL+ FTP L++F D YLVM M +L ++++ + L Sbjct: 86 HAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMD-LD 144 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTG 184 DR+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT Sbjct: 145 HDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP 204 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 YVVTR+YRAPEVIL M YT+ VDIWSVGCIM EMI G LF G+DH+DQ +I++ GT Sbjct: 205 YVVTRYYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 263 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-------------ASPLAVNLLEKM 291 P F+QRLQ +NY++ P F + + + A NLL KM Sbjct: 264 PSPSFMQRLQ-PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 322 Query: 292 LVLDAEQRVTAGEALAHPYFESLHDTE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 LV+D EQR++ EAL H Y +D E D P + YD S D+ + T+++WK + Y+EV+ Sbjct: 323 LVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVM 382 Query: 350 SFKPPRQLGARV 361 ++ Sbjct: 383 DYEAHNTNNRTR 394 >6DTL-A nrPDB Length = 364 Score = 373 bits (957), Expect = e-104, Method: Composition-based stats. Identities = 149/351 (42%), Positives = 223/351 (63%), Gaps = 7/351 (1%) Query: 11 FYRQEVTKTAWEVRAVYRD-LQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 F + + +EV A Y+ + P+G GAYG VCSA++ T VAIKK+ F +++ AK Sbjct: 15 FIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAK 74 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK-HEKLGED 128 R RE++LL+HM HEN++ + D+ P + F D Y+ M TDL ++++ ++ L E+ Sbjct: 75 RTLREIKLLRHMDHENIVAIRDII-PPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEE 133 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR--QADSEMTGYV 186 Q+ +YQ+L+GL+YIH+A ++HRDLKP NL +N +C+LKI DFGLAR MT YV Sbjct: 134 HCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV 193 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 VTRWYRAPE++LN YT +D+WSVGCI E++ K LF G DH+ QL+ +M++ GT P Sbjct: 194 VTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGT-P 252 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 +E ++ AK Y++ LP ++ PLA++L+EKML D +R+T +AL Sbjct: 253 SEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 307 AHPYFESLHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 AHPY SLHD DEP+ ++ F++ + ++ K + Y+E L+F P Q Sbjct: 313 AHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 363 >3E7O-A nrPDB Length = 360 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 166/358 (46%), Positives = 233/358 (65%), Gaps = 19/358 (5%) Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 S FY +V + + V Y+ L+P+GSGA G VC+A D G VA+KKL RPFQ++ A Sbjct: 6 SQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA 65 Query: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 KRAYREL LLK + H+N+I LL+VFTP +TL++F D YLVM M +L +++ H +L + Sbjct: 66 KRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-HMELDHE 124 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYV 186 R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + MT YV Sbjct: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV 184 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 VTR+YRAPEVIL M Y + VDIWSVGCIM E++ G +F+G+DH+DQ ++++ GTP Sbjct: 185 VTRYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPS 243 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN------------ASPLAVNLLEKMLVL 294 AEF+ LQ +NY++ P F + + + A +LL KMLV+ Sbjct: 244 AEFMAALQ-PTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVI 302 Query: 295 DAEQRVTAGEALAHPYFESLHDT--EDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS 350 D ++R++ EAL HPY +D + P Q YD ++ + ++EWK + YKEV+ Sbjct: 303 DPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMD 360 >4QTB-A nrPDB Length = 380 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 148/358 (41%), Positives = 220/358 (61%), Gaps = 10/358 (2%) Query: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 P G + V ++V Y LQ +G GAYG V SA D +VAIKK+ PF Sbjct: 20 GVGPGVPG-EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PF 77 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH 122 + + + +R RE+++L RHENVIG+ D+ TL+ D Y+V M TDL KL+K Sbjct: 78 EHQTYCQRTLREIQILLRFRHENVIGIRDI-LRASTLEAMRDVYIVQDLMETDLYKLLKS 136 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE- 181 ++L D I + +YQ+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E Sbjct: 137 QQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEH 196 Query: 182 -----MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 +T YV TRWYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL Sbjct: 197 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLN 256 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 I+ + G+P E + + + +A+NY++ LP K +A + + A++LL++ML + Sbjct: 257 HILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNP 316 Query: 297 EQRVTAGEALAHPYFESLHDTEDEPQV-QKYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 +R+T EALAHPY E +D DEP + + + + D + K + ++E F+P Sbjct: 317 NKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 374 >5Z33-A nrPDB Length = 425 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 146/346 (42%), Positives = 213/346 (61%), Gaps = 11/346 (3%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 V + V Y + +G GAYG VC+AV+ +T VAIKK+ F ++ AKRA RE+ Sbjct: 22 VFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREI 81 Query: 76 RLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFL 133 +LL+H R H N+ L D+ P D+F + YL M DL +++ + L + Q Sbjct: 82 KLLQHFRGHRNITCLYDMDIPRP--DNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSF 139 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYV 186 +YQ+L GL+YIH+A ++HRDLKPGNL VN DCELKI DFGLAR + MT YV Sbjct: 140 IYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYV 199 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 TRWYRAPE++L++ YT+ +D+WSVGCI+AE++ G+ FKG D++DQL +I+ + GTP Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 E + R+ S A+ Y++ LP + KK F ++ NA+P A++LL++ML D R++ +AL Sbjct: 260 EETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQAL 319 Query: 307 AHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 HPY HD DEP + +V + E +++ EV F+ Sbjct: 320 EHPYLHIWHDASDEPDCPTTFNFDFEVVEDVGEMRKMILDEVYRFR 365 >4IC8-A nrPDB Length = 442 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 134/346 (38%), Positives = 206/346 (59%), Gaps = 9/346 (2%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 ++V Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LK Sbjct: 50 TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 109 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQML 138 H +H+N+I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L Sbjct: 110 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWY 191 +GL+Y+H+A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWY Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 RAPE++L+ YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + ++ + Y++ LP + + ++ A A++LL +ML + R++A AL HP+ Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 349 Query: 312 ESLHDTEDEPQV-QKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 HD +DEP +D +FD T + K E+ F R+ Sbjct: 350 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 395 >5NGU-A nrPDB Length = 381 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 146/347 (42%), Positives = 219/347 (63%), Gaps = 13/347 (3%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 V ++V Y +L +G GAYG VCSA D +VAIKK+ PF+ + + +R RE+ Sbjct: 33 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREI 91 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVY 135 ++L RHEN+IG+ D+ T++ D Y+V M TDL KL+K + L D I + +Y Sbjct: 92 KILLRFRHENIIGINDII-RAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 150 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTR 189 Q+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR Sbjct: 151 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 210 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 WYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E Sbjct: 211 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 270 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 + + + +A+NY+ LP K + + NA A++LL+KML + +R+ +ALAHP Sbjct: 271 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 310 YFESLHDTEDEPQVQ---KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 Y E +D DEP + K+D DD+ + ++ K + ++E F+P Sbjct: 331 YLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQP 375 >4ZSG-A nrPDB Length = 347 Score = 359 bits (921), Expect = 1e-99, Method: Composition-based stats. Identities = 134/346 (38%), Positives = 206/346 (59%), Gaps = 9/346 (2%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 ++V Y ++ +G+GAYG V SA TG +VAIKK+ F AKR REL++LK Sbjct: 2 TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK 61 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQML 138 H +H+N+I + D+ P +F Y+V+ M +DL +++ + L + +++ +YQ+L Sbjct: 62 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWY 191 +GL+Y+H+A +IHRDLKP NL VNE+CELKI DFG+AR + MT YV TRWY Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 RAPE++L+ YTQ +D+WSVGCI EM+ + LF G +++ QL+ IM V GTP +Q Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + ++ + Y++ LP + + ++ A A++LL +ML + R++A AL HP+ Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 301 Query: 312 ESLHDTEDEPQV-QKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 HD +DEP +D +FD T + K E+ F R+ Sbjct: 302 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARRE 347 >3FI2-A nrPDB Length = 353 Score = 356 bits (914), Expect = 9e-99, Method: Composition-based stats. Identities = 163/366 (44%), Positives = 231/366 (63%), Gaps = 27/366 (7%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS FY EV + + V Y++L+P+GSGA G VC+A D VAIKKL R Sbjct: 1 MSKSKVDN-QFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSR 59 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 PFQ++ AKRAYREL L+K + H+N+I LL+VFTP +TL++F D YLVM M +L +++ Sbjct: 60 PFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI 119 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 + E L +R+ +L+YQML G++++H+AGIIHRDLKP N+ V DC LKILDFGLAR A + Sbjct: 120 QME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 178 Query: 181 E--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 MT YVVTR+YRAPEVIL M Y + VDIWSVGCIM EM+ K LF G D++DQ ++ Sbjct: 179 SFMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 237 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA------------SPLAVN 286 ++ GTP EF+++LQ +NY++ P+ F + ++ + A + Sbjct: 238 IEQLGTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD 296 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYK 346 LL KMLV+D +R++ +AL HPY + D+ + T++EWK + YK Sbjct: 297 LLSKMLVIDPAKRISVDDALQHPYINVWYXX---------XXXXDEREHTIEEWKELIYK 347 Query: 347 EVLSFK 352 EV++ + Sbjct: 348 EVMNSE 353 >2F9G-A nrPDB Length = 353 Score = 356 bits (913), Expect = 1e-98, Method: Composition-based stats. Identities = 133/349 (38%), Positives = 210/349 (60%), Gaps = 21/349 (6%) Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80 + + + ++ +G GAYG VCSA TG VAIKK+ PF LFA R RE+++LKH Sbjct: 7 YNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKH 65 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 +HEN+I + ++ PD + ++F + Y++ M TDL +++ + L +D IQ+ +YQ L+ Sbjct: 66 FKHENIITIFNIQRPD-SFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRA 124 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD-------------SEMTGYVV 187 ++ +H + +IHRDLKP NL +N +C+LK+ DFGLAR D S MT YV Sbjct: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 TRWYRAPEV+L +Y++ +D+WS GCI+AE+ + +F G D+ QL I + GTP + Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Query: 248 E-FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 + ++ ++S A+ Y+K LP + +P ++LL++MLV D +R+TA EAL Sbjct: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEAL 304 Query: 307 AHPYFESLHDTEDEPQVQKYDDSFDDVDRTLD-----EWKRVTYKEVLS 350 HPY ++ HD DEP+ + SF + D + + K++ + E+ S Sbjct: 305 EHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS 353 >4QNY-A nrPDB Length = 354 Score = 337 bits (865), Expect = 4e-93, Method: Composition-based stats. Identities = 125/336 (37%), Positives = 203/336 (60%), Gaps = 7/336 (2%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVD-GRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKH 80 + Y + +G+G+YG V A D VA+K++ + E + AKR RE++LL H Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRIQFLVYQMLK 139 +N+IGL ++ TP++ ++F FY+VM M TDL ++++ ++L E IQF +YQ L+ Sbjct: 78 FNDDNIIGLRNILTPEDP-ENFDHFYIVMDIMETDLKQVLRSGQELTEAHIQFFIYQALR 136 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEV 196 L IH+AG+IHRD+ P N+ VN +C+LKI DFGLA++ + + MT YV RWYRAPE+ Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 ++ Y+ +D+W +GCI+ E++ + LF+G D ++QL +I+ V GTP E + + S Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 A+ Y+K + D+ ASP A++LL MLV + ++R+T +A+ HP+ E LHD Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 Query: 317 TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 D+ ++ +T+ + KR Y+E + F Sbjct: 317 DADDNLSYALFRFDENEQKTIVDVKRAIYEESVKFH 352 >4O2Z-A nrPDB Length = 377 Score = 334 bits (856), Expect = 4e-92, Method: Composition-based stats. Identities = 137/357 (38%), Positives = 201/357 (56%), Gaps = 8/357 (2%) Query: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 S P F V+ + +EV + Y L+ +G GAYG CS +DG TG KV+IKK F Sbjct: 23 SVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVF 82 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTP-DETLDDFTDFYLVMPFMGTDLGKLMK 121 + KR RE+ +++ HEN++ ++++ P F D Y+V P M D+ +++ Sbjct: 83 RDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLR 142 Query: 122 -HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD- 179 + L E +Q+ VYQ+L+GL+Y+H+A + HRDLKP NL N CELKI+DFGL+R D Sbjct: 143 SRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDV 202 Query: 180 --SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 SE+T YV+TRWYR PE++L Y+ VDIWSVGCI AEM K +F G + +DQL+ Sbjct: 203 PYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRM 262 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 I + G PPA V+ ++ E N + K + N ++ L KM LD Sbjct: 263 IAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNT--EGIDFLSKMWTLDPS 320 Query: 298 QRVTAGEALAHPYFESLHDTEDEPQVQ-KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353 +R TA + LAHPY LHD EDEP + + + + E +R + +++ + P Sbjct: 321 KRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNP 377 >3OZ6-A nrPDB Length = 388 Score = 333 bits (855), Expect = 5e-92, Method: Composition-based stats. Identities = 122/372 (32%), Positives = 204/372 (54%), Gaps = 47/372 (12%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 V Y ++ +G GAYG V ++D RTG VA+KK++ FQ+ A+R +RE+ +L + Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 82 R-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 HEN++ LL+V D + D YLV +M TDL +++ L Q++VYQ++K Sbjct: 66 SGHENIVNLLNVLRAD----NDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKV 121 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---------------------- 178 ++Y+H+ G++HRD+KP N+ +N +C +K+ DFGL+R Sbjct: 122 IKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFD 181 Query: 179 --DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 +T YV TRWYRAPE++L +YT+ +D+WS+GCI+ E++ GK +F GS ++QL+ Sbjct: 182 DDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPE------LEKKDFASILTN----------A 280 I+ V P E V+ +QS AK ++ L E K+D + N Sbjct: 242 RIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADC 301 Query: 281 SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDD--SFDDVDRTLD 338 + A++LL+K+L + +R++A +AL HP+ H+ +EP D+V ++D Sbjct: 302 NEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSID 361 Query: 339 EWKRVTYKEVLS 350 +++ + Y E+ Sbjct: 362 DYRNLVYSEISR 373 >2BPM-A nrPDB Length = 309 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 108/299 (36%), Positives = 162/299 (54%), Gaps = 14/299 (4%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 ++ ++ +G G YG V A + TG VA+KK+ ++E A RE+ LLK + H Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 66 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL---GEDRIQFLVYQMLKGL 141 N++ LLDV + YLV F+ DL K M L I+ ++Q+L+GL Sbjct: 67 NIVKLLDVIHTE------NKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVIL 198 + H+ ++HRDLKP NL +N + +K+ DFGLAR + Y VVT WYRAPE++L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y+ VDIWS+GCI AEM+T + LF G +DQL I + GTP + S Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-- 238 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 +Y P+ ++DF+ ++ +LL +ML D +R++A ALAHP+F+ + Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 >3RP9-A nrPDB Length = 458 Score = 331 bits (849), Expect = 3e-91, Method: Composition-based stats. Identities = 134/406 (33%), Positives = 209/406 (51%), Gaps = 65/406 (16%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 + W++ Y +G+G+YG VC A D VAIKK+ R F+ + KR RE+ +L Sbjct: 47 SDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAIL 106 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQM 137 + H++V+ +LD+ P + ++ F + Y+V+ +D KL + L E I+ L+Y + Sbjct: 107 NRLNHDHVVKVLDIVIPKD-VEKFDELYVVLEIADSDFKKLFRTPVYLTELHIKTLLYNL 165 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD------------------ 179 L G++Y+H+AGI+HRDLKP N VN+DC +K+ DFGLAR D Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDM 225 Query: 180 ------------SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT------ 221 ++TG+VVTRWYRAPE+IL YT+ +D+WS+GCI AE++ Sbjct: 226 NLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENV 285 Query: 222 -----GKTLFKGSD--------------------HLDQLKEIMKVTGTPPAEFVQRLQSD 256 LF GS + DQL I + GTP E ++ L+ + Sbjct: 286 AYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKE 345 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 +AK Y++ P+ E D A +S A++LL++MLV + +R+T E LAHP+F+ + Sbjct: 346 DAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRI 405 Query: 317 TEDEPQV-QKYDDSFDD-VDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 E E +K F+D ++ + + KE+ + P QL R Sbjct: 406 AEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRR 451 >3NIZ-A nrPDB Length = 311 Score = 319 bits (818), Expect = 1e-87, Method: Composition-based stats. Identities = 119/316 (37%), Positives = 171/316 (54%), Gaps = 20/316 (6%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q + + Y+ L+ VG G YG V A D + G VA+K++ + E Sbjct: 9 SGRENLYFQGLMEK-------YQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDE 60 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK- 124 A RE+ LLK + H N++ L+DV + L LV FM DL K++ K Sbjct: 61 GIPSTAIREISLLKELHHPNIVSLIDVIHSERCLT------LVFEFMEKDLKKVLDENKT 114 Query: 125 -LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 L + +I+ +YQ+L+G+ + H I+HRDLKP NL +N D LK+ DFGLAR + Sbjct: 115 GLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVR 174 Query: 184 GY---VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 Y VVT WYRAP+V++ +Y+ +VDIWS+GCI AEMITGK LF G DQL +I Sbjct: 175 SYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFS 234 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + GTP ++Q + EKK ++SI+ ++LL ML D +R+ Sbjct: 235 ILGTPNPREWPQVQELPLWK-QRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI 293 Query: 301 TAGEALAHPYFESLHD 316 +A +A+ HPYF+ L Sbjct: 294 SARDAMNHPYFKDLDP 309 >3N9X-A nrPDB Length = 432 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 133/411 (32%), Positives = 197/411 (47%), Gaps = 59/411 (14%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q + V Y +G G+YG V A D T VAIKK+ R F+ Sbjct: 9 SGRENLYFQGIKNVH--VPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDL 66 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-K 124 + KR RE+ +L ++ + +I L D+ PD+ L F + Y+V+ +DL KL K Sbjct: 67 IDCKRILREITILNRLKSDYIIRLYDLIIPDDLLK-FDELYIVLEIADSDLKKLFKTPIF 125 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--- 181 L E+ I+ ++Y +L G +IH +GIIHRDLKP N +N+DC +K+ DFGLAR +SE Sbjct: 126 LTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDT 185 Query: 182 ----------------------MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEM 219 +T +VVTRWYRAPE+IL YT+++DIWS GCI AE+ Sbjct: 186 NIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAEL 245 Query: 220 IT-----------GKTLFKGSD-----------------HLDQLKEIMKVTGTPPAEFVQ 251 + LF GS + DQL I + GTP + ++ Sbjct: 246 LNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLK 305 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + E Y+K P + + + S +NLLE ML + +R+T +AL HPY Sbjct: 306 NINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYL 365 Query: 312 ESLHDTEDEP-QVQKYDDSFDD-VDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 + + + E +K FDD + + + + + KEV SF P + + Sbjct: 366 KDVRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKEVQSFHPELVIPSV 416 >6GU6-A nrPDB Length = 302 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 108/299 (36%), Positives = 159/299 (53%), Gaps = 15/299 (5%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y ++ +G G YG V TG VA+KK+ + E A RE+ LLK +RH Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 66 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH----EKLGEDRIQFLVYQMLKG 140 N++ L DV D L YL+ F+ DL K + + + ++ +YQ+L+G Sbjct: 67 NIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVI 197 + + H+ ++HRDLKP NL +++ +K+ DFGLAR T VVT WYR+PEV+ Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 180 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L RY+ VDIWS+G I AE+ T K LF G +DQL I + GTP E ++S Sbjct: 181 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES-- 238 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 ++Y P+ + AS + N ++LL KML+ D +R++ AL HPYF L + Sbjct: 239 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 297 >3NIE-A nrPDB Length = 429 Score = 313 bits (803), Expect = 6e-86, Method: Composition-based stats. Identities = 133/414 (32%), Positives = 200/414 (48%), Gaps = 60/414 (14%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q +V Y +G G+YG V A D VAIKK+ R F+ Sbjct: 9 SGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDL 68 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-K 124 + KR RE+ +L ++ + +I L D+ P++ L F + Y+V+ +DL KL K Sbjct: 69 IDCKRILREITILNRLKSDYIIRLHDLIIPEDLLK-FDELYIVLEIADSDLKKLFKTPIF 127 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--- 181 L E ++ ++Y +L G ++IH +GIIHRDLKP N +N+DC +KI DFGLAR +S+ Sbjct: 128 LTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDI 187 Query: 182 -------------------------MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIM 216 +T +VVTRWYRAPE+IL YT ++DIWS GCI Sbjct: 188 HIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIF 247 Query: 217 AEMI-----------TGKTLFKGS-----------------DHLDQLKEIMKVTGTPPAE 248 AE++ LF GS + DQL I V GTPP E Sbjct: 248 AELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEE 307 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 ++ + E Y+K P + D + ++ S ++LLE ML +A++R+T +AL+H Sbjct: 308 DLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSH 367 Query: 309 PYFESLHDTEDEP-QVQKYDDSFDD-VDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 PY + + E +K FDD + + + + + KE+ SF + A+ Sbjct: 368 PYLKDVRKENLENFSTEKIILPFDDWMVLSETQLRYIFLKEIQSFHADLIIPAK 421 >3PG1-A nrPDB Length = 362 Score = 307 bits (787), Expect = 5e-84, Method: Composition-based stats. Identities = 124/344 (36%), Positives = 197/344 (57%), Gaps = 16/344 (4%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL---------FAKRAYR 73 +++ Y + + SG+YGAVC+ VD G VAIK+++ KR R Sbjct: 20 MQSPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLR 78 Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--GEDRIQ 131 E+RLL H H N++GL D+F E YLV M TDL +++ +++ IQ Sbjct: 79 EIRLLNHFHHPNILGLRDIFVHFEE-PAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQ 137 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTR 189 + +Y +L GL +H AG++HRDL PGN+ + ++ ++ I DF LAR+ AD+ T YV R Sbjct: 138 YFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 WYRAPE+++ + +T+ VD+WS GC+MAEM K LF+GS +QL +I++V GTP E Sbjct: 198 WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIED 257 Query: 250 VQRLQSDEAKNYMKG-LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 V S A++Y++ L + + + +++ A P+A++L+ KML + ++R++ +AL H Sbjct: 258 VVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRH 317 Query: 309 PYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 PYFESL D D + FD+ + + ++ EV F Sbjct: 318 PYFESLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVERFN 361 >1V0B-A nrPDB Length = 288 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 109/294 (37%), Positives = 151/294 (51%), Gaps = 14/294 (4%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y L+ +G G YG V A + G A+KK+ + E RE+ +LK ++H Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKHS 60 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLR 142 N++ L DV + L LV + DL KL+ L + + Q+L G+ Sbjct: 61 NIVKLYDVIHTKKRL------VLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIA 114 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILN 199 Y H ++HRDLKP NL +N + ELKI DFGLAR + Y VVT WYRAP+V++ Sbjct: 115 YCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 +Y+ T+DIWSVGCI AEM+ G LF G DQL I ++ GTP ++ + E Sbjct: 175 SKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVT--ELP 232 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Y E + S L ++LL KML LD QR+TA +AL H YF+ Sbjct: 233 KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4KRC-A nrPDB Length = 317 Score = 303 bits (776), Expect = 8e-83, Method: Composition-based stats. Identities = 102/304 (33%), Positives = 163/304 (53%), Gaps = 24/304 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 ++ L+ +G+G Y V ++ TG VA+K++ + E A RE+ L+K ++HEN+ Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHENI 65 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-------LGEDRIQFLVYQMLK 139 + L DV + L LV FM DL K M L + +++ +Q+L+ Sbjct: 66 VRLYDVIHTENKLT------LVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEV 196 GL + H I+HRDLKP NL +N+ +LK+ DFGLAR + + VVT WYRAP+V Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDV 179 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 ++ Y+ ++DIWS GCI+AEMITGK LF G++ +QLK I + GTP + Sbjct: 180 LMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT-- 237 Query: 257 EAKNYMKGLPELEKKDFASILTNASPL-----AVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + Y + + +D +L + ++ L +L L+ + R++A +AL HP+F Sbjct: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Query: 312 ESLH 315 + Sbjct: 298 AEYY 301 >5EFQ-A nrPDB Length = 347 Score = 301 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 101/330 (30%), Positives = 166/330 (50%), Gaps = 12/330 (3%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + + +G G YG V A D TG VA+KK+ + E F A RE+++L+ + H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 85 NVIGLLDVFTPDETLDDFTD----FYLVMPFMGTDLGKLMKHE--KLGEDRIQFLVYQML 138 ++I + ++ T E DF FYLV +M DL L++ E+ I+ + Q++ Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 130 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAP 194 +GL Y H +HRD+K N+ +N ++K+ DFGLAR SE T V+T WYR P Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 190 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 E++L RYT +D+WS GCI+ E+ T K +F+ + L QL+ I ++ G+P + Sbjct: 191 ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 250 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 N MK + +K A++L + ML LD +R TA +AL + + Sbjct: 251 KLPYFNTMKPKKQYRRK-LREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 309 Query: 315 HDTEDEPQ-VQKYDDSFDDVDRTLDEWKRV 343 ++ P + + D + + K++ Sbjct: 310 EPSKMPPPDLPLWQDCHELWSKKRRRQKQM 339 >4AU8-A nrPDB Length = 296 Score = 300 bits (768), Expect = 7e-82, Method: Composition-based stats. Identities = 104/299 (34%), Positives = 154/299 (51%), Gaps = 16/299 (5%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y L+ +G G YG V A + T VA+K++ E A RE+ LLK ++H+N Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 66 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRY 143 ++ L DV D+ L LV F DL K + L + ++ ++Q+LKGL + Sbjct: 67 IVRLHDVLHSDKKLT------LVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGF 120 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILNW 200 H+ ++HRDLKP NL +N + ELK+ DFGLAR + Y VVT WYR P+V+ Sbjct: 121 CHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGA 180 Query: 201 MRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y+ ++D+WS GCI AE+ G+ LF G+D DQLK I ++ GTP E + Sbjct: 181 KLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPD- 239 Query: 260 NYMKGLPELEK-KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 K P +++ + +LL+ +L + QR++A EAL HPYF Sbjct: 240 --YKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4NST-A nrPDB Length = 351 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 107/363 (29%), Positives = 176/363 (48%), Gaps = 28/363 (7%) Query: 17 TKTAWEVR--AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 T++ W R + + +G G YG V A D TG VA+KK+ + E F A RE Sbjct: 3 TESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIRE 62 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTD----FYLVMPFMGTDLGKLMKHE--KLGED 128 +++L+ + H +V+ + ++ T + DF FYLV +M DL L++ ED Sbjct: 63 IKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSED 122 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTG 184 I+ + Q+++GL Y H +HRD+K N+ +N ++K+ DFGLAR +SE T Sbjct: 123 HIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTN 182 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 V+T WYR PE++L RYT +D+WS GCI+ E+ T K +F+ + L QL+ I ++ G+ Sbjct: 183 KVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGS 242 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE 304 P + N MK + ++ + A++LL+ ML LD +R TA + Sbjct: 243 PCPAVWPDVIKLPYFNTMKPKKQYRRR-LREEFSFIPSAALDLLDHMLTLDPSKRCTAEQ 301 Query: 305 ALAHPYFESLHDTEDEPQ-VQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSK 363 L + + + ++ P + + D + + RQ G V + Sbjct: 302 TLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRR--------------QRQSGVVVEE 347 Query: 364 ETP 366 P Sbjct: 348 PPP 350 >3LIJ-A nrPDB Length = 494 Score = 293 bits (751), Expect = 7e-80, Method: Composition-based stats. Identities = 87/325 (26%), Positives = 151/325 (46%), Gaps = 51/325 (15%) Query: 6 PARSGFYRQE---------VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIK 56 R Y Q +T + +Y+ ++ +GSGAYG V D T + AIK Sbjct: 9 SGRENLYFQGDLQATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIK 68 Query: 57 KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPF--MGT 114 + + S + E+ +LK + H N++ L D F +D ++YLVM G Sbjct: 69 IIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDFF------EDKRNYYLVMECYKGGE 122 Query: 115 DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILD 171 +++ K E ++ Q+L G+ Y+H I+HRDLKP NL + +D +KI+D Sbjct: 123 LFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVD 182 Query: 172 FGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 FGL+ + +M + T +Y APEV+ +Y + D+WS+G I+ ++ G F G Sbjct: 183 FGLSAVFENQKKMKERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQ 240 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 + L+++ K T + + N S A +L++ Sbjct: 241 TDQEILRKVEKGKYTFDSPEWK---------------------------NVSEGAKDLIK 273 Query: 290 KMLVLDAEQRVTAGEALAHPYFESL 314 +ML D+++R++A +AL HP+ + + Sbjct: 274 QMLQFDSQRRISAQQALEHPWIKEM 298 >4AGU-A nrPDB Length = 311 Score = 293 bits (750), Expect = 8e-80, Method: Composition-based stats. Identities = 93/300 (31%), Positives = 156/300 (52%), Gaps = 11/300 (3%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y + +G G+YG V + TG VAIKK + K A RE+R+LK ++H Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHP 62 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTD-LGKLMKHEK-LGEDRIQFLVYQMLKGLR 142 N++ LL+VF L +LV + L +L ++++ + E ++ + +Q L+ + Sbjct: 63 NLVNLLEVFRRKRRL------HLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVN 116 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILN 199 + H IHRD+KP N+ + + +K+ DFG AR Y V TRWYR+PE+++ Sbjct: 117 FCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVG 176 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 +Y VD+W++GC+ AE+++G L+ G +DQL I K G Q +++ Sbjct: 177 DTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 + +K + + N S A+ LL+ L +D +R+T + L HPYFE++ + ED Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 >3NCG-A nrPDB Length = 486 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 84/319 (26%), Positives = 140/319 (43%), Gaps = 48/319 (15%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q Y + +G G++G V D T + A+K + + Sbjct: 9 SGRENLYFQG------TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN 62 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHE 123 RE+ LLK + H N++ L ++ L+D + FY+V G +++K + Sbjct: 63 KDTSTILREVELLKKLDHPNIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKRK 116 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QA 178 + E ++ Q+ G+ Y+H I+HRDLKP N+ + +DC++KI+DFGL+ Q Sbjct: 117 RFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ 176 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 +++M + T +Y APEV+ Y + D+WS G I+ +++G F G + D LK + Sbjct: 177 NTKMKDRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV 234 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 E Y LP+ S A +L+ KML Sbjct: 235 ------------------ETGKYAFDLPQWR---------TISDDAKDLIRKMLTFHPSL 267 Query: 299 RVTAGEALAHPYFESLHDT 317 R+TA + L HP+ + Sbjct: 268 RITATQCLEHPWIQKYSSE 286 >5JN2-A nrPDB Length = 525 Score = 290 bits (742), Expect = 7e-79, Method: Composition-based stats. Identities = 89/338 (26%), Positives = 158/338 (46%), Gaps = 46/338 (13%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 A G + Q T Y+ + +G G++G V D TG + A+K + + + Sbjct: 52 ATPGMFVQHSTAI---FSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQK 108 Query: 67 FAKR-AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHE 123 K RE++LLK + H N++ L + F +D FYLV + G +L +++ + Sbjct: 109 TDKESLLREVQLLKQLDHPNIMKLYEFF------EDKGYFYLVGEVYTGGELFDEIISRK 162 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQAD- 179 + E ++ Q+L G+ Y+H I+HRDLKP NL + ++D ++I+DFGL+ + Sbjct: 163 RFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA 222 Query: 180 -SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 +M + T +Y APEV+ Y + D+WS G I+ +++G F G++ D LK++ Sbjct: 223 SKKMKDKIGTAYYIAPEVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV 280 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 E Y LP+ +K S A +L+ KML Sbjct: 281 ------------------EKGKYTFELPQWKK---------VSESAKDLIRKMLTYVPSM 313 Query: 299 RVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRT 336 R++A +AL H + ++ + V D++ ++ + Sbjct: 314 RISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQF 351 >3DFA-A nrPDB Length = 286 Score = 290 bits (742), Expect = 8e-79, Method: Composition-based stats. Identities = 84/319 (26%), Positives = 140/319 (43%), Gaps = 48/319 (15%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q Y + +G G++G V D T + A+K + + Sbjct: 9 SGRENLYFQG------TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN 62 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHE 123 RE+ LLK + H N++ L ++ L+D + FY+V G +++K + Sbjct: 63 KDTSTILREVELLKKLDHPNIMKLFEI------LEDSSSFYIVGELYTGGELFDEIIKRK 116 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLAR--QA 178 + E ++ Q+ G+ Y+H I+HRDLKP N+ + +DC++KI+DFGL+ Q Sbjct: 117 RFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ 176 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 +++M + T +Y APEV+ Y + D+WS G I+ +++G F G + D LK + Sbjct: 177 NTKMKDRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV 234 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 E Y LP+ S A +L+ KML Sbjct: 235 ------------------ETGKYAFDLPQWR---------TISDDAKDLIRKMLTFHPSL 267 Query: 299 RVTAGEALAHPYFESLHDT 317 R+TA + L HP+ + Sbjct: 268 RITATQCLEHPWIQKYSSE 286 >2I6L-A nrPDB Length = 320 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 115/317 (36%), Positives = 178/317 (56%), Gaps = 18/317 (5%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 +++ + Y DL+P+G G G V SAVD +VAIKK+ K A RE+++++ Sbjct: 6 GFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIR 63 Query: 80 HMRHENVIGLLDVFTPDET--------LDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ 131 + H+N++ + ++ P + L + Y+V +M TDL +++ L E+ + Sbjct: 64 RLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHAR 123 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLARQADSEMTGY----- 185 +YQ+L+GL+YIH+A ++HRDLKP NL +N ED LKI DFGLAR D + Sbjct: 124 LFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSE 183 Query: 186 -VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 +VT+WYR+P ++L+ YT+ +D+W+ GCI AEM+TGKTLF G+ L+Q++ I++ Sbjct: 184 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPV 243 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE 304 E Q L S Y++ K +L S AV+ LE++L R+TA E Sbjct: 244 VHEEDRQELLS-VIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 Query: 305 ALAHPYFESLHDTEDEP 321 AL+HPY DEP Sbjct: 303 ALSHPYMSIYSFPMDEP 319 >1UA2-A nrPDB Length = 346 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 104/297 (35%), Positives = 148/297 (49%), Gaps = 17/297 (5%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY---RPFQSELFAKRAYRELRLLKHM 81 Y L +G G + V A D T VAIKK+ R + + A RE++LL+ + Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--GEDRIQFLVYQMLK 139 H N+IGLLD F + LV FM TDL ++K L I+ + L+ Sbjct: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEV 196 GL Y+H I+HRDLKP NL ++E+ LK+ DFGLA+ S T VVTRWYRAPE+ Sbjct: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + Y VD+W+VGCI+AE++ G LDQL I + GTP E + S Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 K P + I + A ++L++ + + + R+TA +AL YF + Sbjct: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >4BBM-A nrPDB Length = 331 Score = 287 bits (735), Expect = 4e-78, Method: Composition-based stats. Identities = 95/316 (30%), Positives = 154/316 (48%), Gaps = 19/316 (6%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q + K Y +L VG G+YG V + TG VAIKK Sbjct: 10 SGVDLGTENLYFQSMEK--------YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLES 61 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK 121 ++ K A RE++LLK +RHEN++ LL+V + YLV F+ + ++ Sbjct: 62 DDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRW------YLVFEFVDHTILDDLE 115 Query: 122 H--EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA- 178 L +Q ++Q++ G+ + H+ IIHRD+KP N+ V++ +K+ DFG AR Sbjct: 116 LFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLA 175 Query: 179 --DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 V TRWYRAPE+++ ++Y + VD+W++GC++ EM G+ LF G +DQL Sbjct: 176 APGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLY 235 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 IM G + + ++ E++ S + ++L +K L +D Sbjct: 236 HIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDP 295 Query: 297 EQRVTAGEALAHPYFE 312 ++R E L H +F+ Sbjct: 296 DKRPFCAELLHHDFFQ 311 >1G3N-A nrPDB Length = 326 Score = 287 bits (735), Expect = 5e-78, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 157/298 (52%), Gaps = 15/298 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTG-AKVAIKKLYRPFQSELFAKRAYRELRLLKHMR--- 82 Y + +G GAYG V A D + G VA+K++ E RE+ +L+H+ Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH---EKLGEDRIQFLVYQMLK 139 H NV+ L DV T T D T LV + DL + + + I+ +++Q+L+ Sbjct: 73 HPNVVRLFDVCTVSRT-DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLR 131 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM--TGYVVTRWYRAPEVI 197 GL ++H+ ++HRDLKP N+ V ++K+ DFGLAR +M T VVT WYRAPEV+ Sbjct: 132 GLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVL 191 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L Y VD+WSVGCI AEM K LF+GS +DQL +I+ V G P E R + Sbjct: 192 L-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 + + + +T+ L +LL K L + +R++A AL+HPYF+ L Sbjct: 251 RQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 >3MIA-A nrPDB Length = 351 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 100/307 (32%), Positives = 158/307 (51%), Gaps = 12/307 (3%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + Y L +G G +G V A +TG KVA+KK+ + E F A RE+++L+ ++HE Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Query: 85 NVIGLLDVFTPDETLDDFTD--FYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKG 140 NV+ L+++ + + YLV F DL L+ + K I+ ++ +L G Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-------DSEMTGYVVTRWYRA 193 L YIH I+HRD+K N+ + D LK+ DFGLAR + T VVT WYR Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PE++L Y +D+W GCIMAEM T + +G+ QL I ++ G+ E + Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNA-SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + E ++ + ++K + P A++L++K+LVLD QR+ + +AL H +F Sbjct: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 Query: 313 SLHDTED 319 S D Sbjct: 317 SDPMPSD 323 >4MVF-A nrPDB Length = 506 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 76/312 (24%), Positives = 134/312 (42%), Gaps = 44/312 (14%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 + + ++ Y + +G G YG V +D T AIK+ + + R ++E+ Sbjct: 48 ILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI--NRFFQEI 105 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT--DLGKLMKHEKLGEDRIQFL 133 ++K + H N++ L ET ++ YL+M ++++ E + Sbjct: 106 EIMKKLDHPNIVKLY------ETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATI 159 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQADSE--MTGYVVT 188 + Q+ + Y+H+ I+HRDLKP N N+D LKI+DFGL++ + T T Sbjct: 160 MKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGT 219 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 +Y AP+V+ +Y + DIWS G IM ++ G F G + LK++ K Sbjct: 220 PYYVAPQVLDG--KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCF--- 274 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 + + + S A NL+ K+L + +R T EAL H Sbjct: 275 ------------------------YENDWGSISSDAKNLITKLLTYNPNERCTIEEALNH 310 Query: 309 PYFESLHDTEDE 320 P+ + + + Sbjct: 311 PWITQMTKSHEH 322 >3DXN-A nrPDB Length = 287 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 88/314 (28%), Positives = 145/314 (46%), Gaps = 50/314 (15%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q ++ Y+ ++ +GSGAYG V D TGA+ AIK + + + Sbjct: 9 SGRENLYFQGLS-------DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTT 61 Query: 66 LFAK-RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKH 122 E+ +LK + H N++ L + F +D ++YLVM + G +L +++ Sbjct: 62 TSNSGALLDEVAVLKQLDHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILR 115 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQ-- 177 +K E ++ Q+L G Y+H I+HRDLKP NL + + D +KI+DFGL+ Sbjct: 116 QKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFE 175 Query: 178 ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 +M + T +Y APEV+ +Y + D+WS G I+ ++ G F G + LK Sbjct: 176 VGGKMKERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKR 233 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 + KG + D+ + S A L++ ML + Sbjct: 234 VE-----------------------KGKFSFDPPDWTQV----SDEAKQLVKLMLTYEPS 266 Query: 298 QRVTAGEALAHPYF 311 +R++A EAL HP+ Sbjct: 267 KRISAEEALNHPWI 280 >3MA6-A nrPDB Length = 298 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 87/325 (26%), Positives = 151/325 (46%), Gaps = 47/325 (14%) Query: 6 PARSGFYRQE----VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 R Y Q V + Y+ + +G G++G V D TG + A+K + + Sbjct: 9 SGRENLYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKR 68 Query: 62 FQSELFAKR-AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GK 118 + K RE++LLK + H N++ L + F +D FYLV + G +L + Sbjct: 69 QVKQKTDKESLLREVQLLKQLDHPNIMKLYEFF------EDKGYFYLVGEVYTGGELFDE 122 Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLA 175 ++ ++ E ++ Q+L G+ Y+H I+HRDLKP NL + ++D ++I+DFGL+ Sbjct: 123 IISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLS 182 Query: 176 RQAD--SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 + +M + T +Y APEV+ Y + D+WS G I+ +++G F G++ D Sbjct: 183 THFEASKKMKDKIGTAYYIAPEVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYD 240 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 LK++ E Y LP+ +K S A +L+ KML Sbjct: 241 ILKKV------------------EKGKYTFELPQWKK---------VSESAKDLIRKMLT 273 Query: 294 LDAEQRVTAGEALAHPYFESLHDTE 318 R++A +AL H + ++ + Sbjct: 274 YVPSMRISARDALDHEWIQTYTKEQ 298 >5AIR-A nrPDB Length = 430 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 99/325 (30%), Positives = 167/325 (51%), Gaps = 29/325 (8%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P + QEV+ Y D + +G+G++G V A +G VAIKK+ Sbjct: 54 PGQGPDRPQEVS---------YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKV------- 97 Query: 66 LFAKRAY-RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-- 122 L KR REL++++ + H N++ L F D LV+ ++ + ++ +H Sbjct: 98 LQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYS 157 Query: 123 ---EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL-KILDFGLARQA 178 + L ++ +YQ+ + L YIH+ GI HRD+KP NL ++ D + K+ DFG A+Q Sbjct: 158 RAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL 217 Query: 179 --DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 Y+ +R+YRAPE+I YT ++D+WS GC++AE++ G+ +F G +DQL Sbjct: 218 VRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLV 277 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL-TNASPLAVNLLEKMLVLD 295 EI+KV GTP E ++ + + + P+++ + + P A+ L ++L Sbjct: 278 EIIKVLGTPTREQIREMNPNYTE---FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYT 334 Query: 296 AEQRVTAGEALAHPYFESLHDTEDE 320 R+T EA AH +F+ L D + Sbjct: 335 PTARLTPLEACAHSFFDELRDPNVK 359 >3HZT-A nrPDB Length = 467 Score = 283 bits (725), Expect = 7e-77, Method: Composition-based stats. Identities = 85/297 (28%), Positives = 141/297 (47%), Gaps = 43/297 (14%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK-RAYRELRLLKHM 81 + Y+ ++ +GSGAYG V D TGA+ AIK + + + E+ +LK + Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQL 61 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEKLGEDRIQFLVYQMLK 139 H N++ L + F +D ++YLVM + G +L +++ +K E ++ Q+L Sbjct: 62 DHPNIMKLYEFF------EDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 140 GLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAP 194 G Y+H I+HRDLKP NL + + D +KI+DFGL+ +M + T +Y AP Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 175 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ +Y + D+WS G I+ ++ G F G + LK + Sbjct: 176 EVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVE--------------- 218 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 KG + D+ + S A L++ ML + +R++A EAL HP+ Sbjct: 219 --------KGKFSFDPPDWTQV----SDEAKQLVKLMLTYEPSKRISAEEALNHPWI 263 >5G6V-A nrPDB Length = 324 Score = 280 bits (717), Expect = 6e-76, Method: Composition-based stats. Identities = 98/295 (33%), Positives = 149/295 (50%), Gaps = 13/295 (4%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y L +G G Y V T VA+K++ + E A RE+ LLK ++H Sbjct: 2 ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 60 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLR 142 N++ L D+ +++L LV ++ DL + + + ++ ++Q+L+GL Sbjct: 61 NIVTLHDIIHTEKSLT------LVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILN 199 Y H ++HRDLKP NL +NE ELK+ DFGLAR Y VVT WYR P+++L Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y+ +D+W VGCI EM TG+ LF GS +QL I ++ GTP E + S+E Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEF 234 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 P+ + S +LL K+L + R++A +A+ HP+F SL Sbjct: 235 KTY-NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 288 >4E7W-A nrPDB Length = 394 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 106/366 (28%), Positives = 182/366 (49%), Gaps = 26/366 (7%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 KT + Y + + +G+G++G V A + VAIKK+ + + + REL+ Sbjct: 32 GKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQ 84 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQ 131 +++ ++H NV+ L F + D LV+ ++ + + +H + + I+ Sbjct: 85 IMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIK 144 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE-DCELKILDFGLARQA--DSEMTGYVVT 188 +YQ+L+ L YIH+ GI HRD+KP NL ++ LK++DFG A+ Y+ + Sbjct: 145 LYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICS 204 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 R+YRAPE+I YT +DIWS GC+MAE++ G+ LF G +DQL EI+KV GTP E Sbjct: 205 RYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSRE 264 Query: 249 FVQRLQSDEAKNYMK-GLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 ++ NYM+ P++ F+ + P A++L+ ++L R+TA EAL Sbjct: 265 QIK----TMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEAL 320 Query: 307 AHPYFESLHD-----TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARV 361 HP+F+ L ++ + +++ D R+ + + R + Sbjct: 321 CHPFFDELRTGEARMPNGRELPPLFNWTKEELSVRPDLISRLVPQHAEAELLSRGIDVHN 380 Query: 362 SKETPL 367 + PL Sbjct: 381 FQPIPL 386 >2W96-B nrPDB Length = 306 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 109/306 (35%), Positives = 149/306 (48%), Gaps = 17/306 (5%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-- 82 + Y + +G GAYG V A D +G VA+K + P E RE+ LL+ + Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 83 -HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQML 138 H NV+ L+DV T D LV + DL + L + I+ L+ Q L Sbjct: 64 EHPNVVRLMDVCATSRT-DREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM--TGYVVTRWYRAPEV 196 +GL ++HA I+HRDLKP N+ V +K+ DFGLAR +M VVT WYRAPEV Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 +L Y VD+WSVGCI AEM K LF G+ DQL +I + G PP + R S Sbjct: 183 LL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 + P + S++ LL +ML + +R++A AL H Y LH Sbjct: 242 PRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY---LHK 294 Query: 317 TEDEPQ 322 E P+ Sbjct: 295 DEGNPE 300 >2VN9-A nrPDB Length = 301 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 130/297 (43%), Gaps = 42/297 (14%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 + Y+ + +G GA+ V + TG + A K + S ++ RE R+ + ++ Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 H N++ L D + + YLV + G ++ E E + Q+L+ Sbjct: 62 HPNIVRLHDSISEEGF------HYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILES 115 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAP 194 + + H GI+HRDLKP NL + + +K+ DFGLA + + G+ T Y +P Sbjct: 116 VNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSP 175 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ Y + VD+W+ G I+ ++ G F D ++I Sbjct: 176 EVLRKD-PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQI---------------- 218 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 219 --KAGAYDFPSPEWD---------TVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >5U6Y-A nrPDB Length = 461 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 130/296 (43%), Gaps = 42/296 (14%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 +Y+ + +G GA+ V V G + A K + S ++ RE R+ + ++H N Sbjct: 1 MYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 60 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 ++ L D + + YL+ + G ++ E E + Q+L+ + + Sbjct: 61 IVRLHDSISEEG------HHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 114 Query: 144 IHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAPEVI 197 H G++HRDLKP NL + + +K+ DFGLA + + E G+ T Y +PEV+ Sbjct: 115 CHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 174 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 Y + VD+W+ G I+ ++ G F D ++I + Sbjct: 175 RKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------K 215 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 216 AGAYDFPSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 262 >5FG8-A nrPDB Length = 285 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 128/295 (43%), Gaps = 42/295 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y + +G GA+ V V TG + A K + + ++ RE R+ + + H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L D ++ + YLV + G ++ E E + Q+L+ + Sbjct: 74 NIVRLHD------SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVN 127 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAPEV 196 + H G++HRDLKP NL + + +K+ DFGLA + + G+ T Y +PEV Sbjct: 128 HCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV 187 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + Y ++VDIW+ G I+ ++ G F D +I Sbjct: 188 L-KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQI------------------ 228 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A Y PE + +P A NL+ +ML ++ +R+TA EAL HP+ Sbjct: 229 KAGAYDYPSPEWD---------TVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >2VZ6-A nrPDB Length = 313 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 134/320 (41%), Gaps = 52/320 (16%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q ++Y+ + +G GA+ V V G + A K + Sbjct: 9 SGVDLGTENLYFQ----------SMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTK 58 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL 119 S ++ RE R+ + ++H N++ L D + + YL+ + G + Sbjct: 59 KLSARDHQKLEREARICRLLKHPNIVRLHDSISEEG------HHYLIFDLVTGGELFEDI 112 Query: 120 MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLAR 176 + E E + Q+L+ + + H G++HRDLKP NL + + +K+ DFGLA Sbjct: 113 VAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAI 172 Query: 177 QADSEMT---GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 + + E G+ T Y +PEV+ Y + VD+W+ G I+ ++ G F D Sbjct: 173 EVEGEQQAWFGFAGTPGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHR 231 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 ++I +A Y PE + +P A +L+ KML Sbjct: 232 LYQQI------------------KAGAYDFPSPEWD---------TVTPEAKDLINKMLT 264 Query: 294 LDAEQRVTAGEALAHPYFES 313 ++ +R+TA EAL HP+ Sbjct: 265 INPSKRITAAEALKHPWISH 284 >2V7O-A nrPDB Length = 336 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 135/319 (42%), Gaps = 45/319 (14%) Query: 2 SSPPPARSGFYRQE-VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 S Y Q T T + Y+ + +G GA+ V V + A K + Sbjct: 9 SGVDLGTENLYFQSMATCTRF--TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINT 66 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGK 118 S ++ RE R+ + ++H N++ L D + + YLV + G Sbjct: 67 KKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGF------HYLVFDLVTGGELFED 120 Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLA 175 ++ E E ++Q+L+ + +IH I+HRDLKP NL + C+ +K+ DFGLA Sbjct: 121 IVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA 180 Query: 176 RQADSEMT---GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 + E G+ T Y +PEV+ Y + VDIW+ G I+ ++ G F D Sbjct: 181 IEVQGEQQAWFGFAGTPGYLSPEVLRKD-PYGKPVDIWACGVILYILLVGYPPFWDEDQH 239 Query: 233 DQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKML 292 ++I +A Y PE + +P A NL+ +ML Sbjct: 240 KLYQQI------------------KAGAYDFPSPEWD---------TVTPEAKNLINQML 272 Query: 293 VLDAEQRVTAGEALAHPYF 311 ++ +R+TA +AL HP+ Sbjct: 273 TINPAKRITADQALKHPWV 291 >3Q5I-A nrPDB Length = 504 Score = 274 bits (700), Expect = 6e-74, Method: Composition-based stats. Identities = 91/362 (25%), Positives = 149/362 (41%), Gaps = 61/362 (16%) Query: 6 PARSGFYRQE--------VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKK 57 R Y Q V K ++ Y ++ +GSGAYG V + ++ AIK Sbjct: 9 SGRENLYFQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKV 68 Query: 58 LYRPFQS-----------ELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFY 106 + + E F + Y E+ LLK + H N+I L DVF +D FY Sbjct: 69 IKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVF------EDKKYFY 122 Query: 107 LVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED 164 LV F G +++ K E ++ Q+L G+ Y+H I+HRD+KP N+ + Sbjct: 123 LVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENK 182 Query: 165 C---ELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEM 219 +KI+DFGL+ D ++ + T +Y APEV+ +Y + D+WS G IM + Sbjct: 183 NSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYIL 240 Query: 220 ITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTN 279 + G F G + D +K++ K + N Sbjct: 241 LCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWK---------------------------N 273 Query: 280 ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDE 339 S A L++ ML D +R TA EAL + + + ++ + + ++ + Sbjct: 274 ISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKYANNINKSDQKTLCGALSNMRKFEGS 333 Query: 340 WK 341 K Sbjct: 334 QK 335 >3BHH-A nrPDB Length = 295 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 131/297 (44%), Gaps = 42/297 (14%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 + Y+ + +G GA+ V V TG + A K + S ++ RE R+ + ++ Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK 61 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 H N++ L D + + YLV + G ++ E E + Q+L+ Sbjct: 62 HSNIVRLHDSISEEGF------HYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEA 115 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAP 194 + + H G++HRDLKP NL + C+ +K+ DFGLA + + G+ T Y +P Sbjct: 116 VLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSP 175 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ Y + VDIW+ G I+ ++ G F D ++I Sbjct: 176 EVLRK-EAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQI---------------- 218 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A Y PE + +P A NL+ +ML ++ +R+TA EAL HP+ Sbjct: 219 --KAGAYDFPSPEWD---------TVTPEAKNLINQMLTINPAKRITAHEALKHPWV 264 >5ES1-A nrPDB Length = 328 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 138/317 (43%), Gaps = 41/317 (12%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 YR L+ +G G + V A TG +VAIK + + + ++ +RE+R++K + H Sbjct: 15 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 74 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L +V ++TL YLVM + G L+ H ++ E + Q++ + Sbjct: 75 NIVKLFEVIETEKTL------YLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVH 128 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNW 200 Y H I+HRDLK NL ++ + +KI DFG + + S++ + + Y APE+ Sbjct: 129 YCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGK 188 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 VDIWS+G I+ +++G F G + + + +++ P +S Sbjct: 189 KYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCES----- 243 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 +L + LVL+ +R T + + + ++ E+ Sbjct: 244 --------------------------ILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEEL 277 Query: 321 PQVQKYDDSFDDVDRTL 337 + ++ F D R Sbjct: 278 KPYTEPEEDFGDTKRIE 294 >2BDW-A nrPDB Length = 362 Score = 271 bits (694), Expect = 3e-73, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 132/297 (44%), Gaps = 41/297 (13%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + Y + +G GA+ V V TG + A K + S ++ RE R+ + + Sbjct: 26 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 85 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 +H N++ L D ++ + + YLV + G ++ E E + Q+L+ Sbjct: 86 QHPNIVRLHD------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILE 139 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEM--TGYVVTRWYRAP 194 + Y H+ GI+HR+LKP NL + + +K+ DFGLA + + G+ T Y +P Sbjct: 140 SIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSP 199 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ Y++ VDIW+ G I+ ++ G F D +I Sbjct: 200 EVLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI---------------- 242 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A Y PE + +P A +L++ ML ++ ++R+TA +AL P+ Sbjct: 243 --KAGAYDYPSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >4YZB-A nrPDB Length = 491 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 90/343 (26%), Positives = 157/343 (45%), Gaps = 46/343 (13%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YR 60 S A G + Q T Y+ + +G G++G V D TG + A+K + R Sbjct: 10 SDKLAATPGMFVQHSTAA---FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKR 66 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GK 118 + + + +E+ LLK + H N++ L + F +D FYLV + G +L + Sbjct: 67 QVKQKTDKELLLKEVELLKKLDHPNIMKLYEFF------EDKGYFYLVTEVYTGGELFDE 120 Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLA 175 ++ ++ E ++ Q+L G+ Y+H I+HRDLKP NL + +D ++I+DFGL+ Sbjct: 121 IISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLS 180 Query: 176 RQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 +S M + T +Y APEV+ Y + D+WS G I+ +++G F G++ D Sbjct: 181 THFESTKKMKDKIGTAYYIAPEVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEFD 238 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 LK++ K T LP+ +K S A +L+ KML Sbjct: 239 ILKKVEKGKFTF------------------DLPQWKK---------VSEPAKDLIRKMLA 271 Query: 294 LDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRT 336 R++A +AL H + ++ D V + + ++ + Sbjct: 272 YVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTILNIRQF 314 >5IG1-A nrPDB Length = 344 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 82/333 (24%), Positives = 141/333 (42%), Gaps = 60/333 (18%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G GA+ V V+ RTG A+K + + RE+ + ++HE+++ + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 92 VFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 F D + FYLV ++ G +++ + E ++Q+L L++ H+ I Sbjct: 84 AFR------DESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNI 137 Query: 150 IHRDLKPGNLAV---NEDCELKILDFGLARQADSEMT--GYVVTRWYRAPEVILNWMRYT 204 IHRDLKP NL + + + +KI DFGLA + T G+ T Y +PEVI + Y Sbjct: 138 IHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI-RRVPYD 196 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 VD+W+ G I+ ++ G F DH +I P+ Sbjct: 197 TAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPS----------------- 239 Query: 265 LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQ 324 PE + + + A L++ ML + ++R T E L HP+ Sbjct: 240 -PEWD---------SVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI------------- 276 Query: 325 KYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQL 357 + DV ++ ++ T +E+ F R+L Sbjct: 277 ----ARRDVPGSVH--RQATLEELKKFNARRKL 303 >4RGJ-A nrPDB Length = 520 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 156/321 (48%), Gaps = 47/321 (14%) Query: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSEL 66 R G + Q Y+ ++ +G G++G V + D TG + AIK + + + + Sbjct: 46 RPGMFIQNSNVV---FNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKT 102 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDL-GKLMKHEK 124 + RE+ LLK + H N++ L + F +D +YLV + G +L +++ ++ Sbjct: 103 DKESLLREVELLKMLDHINIMKLYEFF------EDNNYYYLVSDVYTGGELFDEIISRKR 156 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV----NEDCELKILDFGLARQAD- 179 E ++ Q+L G+ Y+H ++HRDLKP N+ + ED +KI+DFGL+ + Sbjct: 157 FYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEY 216 Query: 180 -SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 +M + T +Y AP+V+ Y + DIWS G I+ +++G F GS+ D LK++ Sbjct: 217 SKKMKDKIGTAYYIAPDVLHG--TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV 274 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 EA Y LP+ +K S A +L++KML+ + Sbjct: 275 ------------------EAGKYTFDLPQFKK---------ISDKAKDLIKKMLMYTSAV 307 Query: 299 RVTAGEALAHPYFESLHDTED 319 R++A +AL H + + + ++ Sbjct: 308 RISARDALEHEWIKMMTSKDN 328 >3SOA-A nrPDB Length = 444 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 128/297 (43%), Gaps = 42/297 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y+ + +G GA+ V V G + A + S ++ RE R+ + ++H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L D + + YL+ + G ++ E E + Q+L+ + Sbjct: 71 NIVRLHDSISEEG------HHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 124 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMT---GYVVTRWYRAPEV 196 + H G++HR+LKP NL + + +K+ DFGLA + + E G+ T Y +PEV Sbjct: 125 HCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 184 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + Y + VD+W+ G I+ ++ G F D ++I Sbjct: 185 LRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQI------------------ 225 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 +A Y PE + +P A +L+ KML ++ +R+TA EAL HP+ Sbjct: 226 KAGAYDFPSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 273 >4FG9-A nrPDB Length = 320 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 83/341 (24%), Positives = 148/341 (43%), Gaps = 58/341 (17%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 K A ++R +Y +G+GA+ V A D RT VAIK + + E E+ + Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL-EGKEGSMENEIAV 69 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVY 135 L ++H N++ L D++ YL+M + G ++++ E L++ Sbjct: 70 LHKIKHPNIVALDDIYESGG------HLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF 123 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLA---VNEDCELKILDFGLARQADSE--MTGYVVTRW 190 Q+L ++Y+H GI+HRDLKP NL ++ED ++ I DFGL++ D ++ T Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 Y APEV+ Y++ VD WS+G I ++ G F + ++I+K + + Sbjct: 184 YVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYW 242 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 + S A + + ++ D E+R T +AL HP+ Sbjct: 243 D---------------------------DISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275 Query: 311 F-------ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVT 344 +++H + E + + S +WK+ Sbjct: 276 IAGDTALDKNIHQSVSEQIKKNFAKS---------KWKQAF 307 >2QNJ-A nrPDB Length = 328 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 148/341 (43%), Gaps = 54/341 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 YR L+ +G G + V A TG +VAIK + + + ++ +RE+R++K + H Sbjct: 12 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 71 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L +V ++TL YL+M + G L+ H ++ E + Q++ ++ Sbjct: 72 NIVKLFEVIETEKTL------YLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQ 125 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNW 200 Y H I+HRDLK NL ++ D +KI DFG + + ++ + + Y APE+ Sbjct: 126 YCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGK 185 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 VD+WS+G I+ +++G F G + + + +++ P Sbjct: 186 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM----------- 234 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED- 319 S NLL++ LVL+ +R T + + + + H+ ++ Sbjct: 235 --------------------STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDEL 274 Query: 320 ----EPQVQKYDDSFDDV--------DRTLDEWKRVTYKEV 348 EP++ D D+ + + ++ Y E+ Sbjct: 275 KPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEI 315 >3MN3-A nrPDB Length = 271 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 128/292 (43%), Gaps = 41/292 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK-RAYRELRLLKHMRH 83 Y+ ++ +G G++G V A TG KVA+K + + ++ + R RE+ L+ +RH Sbjct: 4 GNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLR 142 ++I L DV + + +V+ + G +L +++ +K+ E + Q++ + Sbjct: 64 PHIIKLYDV------IKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVE 117 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNW 200 Y H I+HRDLKP NL ++E +KI DFGL+ + + Y APEVI Sbjct: 118 YCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGK 177 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 + VD+WS G I+ M+ + F K I T P Sbjct: 178 LYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFL----------- 226 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 SP A L+++ML+++ R++ E + +F+ Sbjct: 227 --------------------SPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >3KK8-A nrPDB Length = 284 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 132/297 (44%), Gaps = 41/297 (13%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + Y + +G GA+ V V TG + A K + S ++ RE R+ + + Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL 62 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 +H N++ L D ++ + + YLV + G ++ E E + Q+L+ Sbjct: 63 QHPNIVRLHD------SIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILE 116 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEM--TGYVVTRWYRAP 194 + Y H+ GI+HR+LKP NL + + +K+ DFGLA + + G+ T Y +P Sbjct: 117 SIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSP 176 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ Y++ VDIW+ G I+ ++ G F D +I Sbjct: 177 EVLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQI---------------- 219 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A Y PE + +P A +L++ ML ++ ++R+TA +AL P+ Sbjct: 220 --KAGAYDYPSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >4BGQ-A nrPDB Length = 304 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 93/305 (30%), Positives = 160/305 (52%), Gaps = 20/305 (6%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 V + L VG GAYG V T VAIKK ++E + REL++L Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKML 65 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK--LGEDRIQFLVYQ 136 + ++ EN++ L + F L YLV ++ ++ +L++ + ++++ +YQ Sbjct: 66 RTLKQENIVELKEAFRRRGKL------YLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQ 119 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA----DSEMTGYVVTRWYR 192 ++K + + H I+HRD+KP NL ++ + LK+ DFG AR ++ V TRWYR Sbjct: 120 LIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 +PE++L Y ++VD+WSVGCI+ E+ G+ LF G +DQL I KV G P+E ++ Sbjct: 180 SPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKL 238 Query: 253 LQSDEAKNYMK----GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 S+ + ++ P+ ++ + IL + ++L++ +L LD R + L H Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERRYLGILNSV---LLDLMKNLLKLDPADRYLTEQCLNH 295 Query: 309 PYFES 313 P F++ Sbjct: 296 PTFQT 300 >5Y86-A nrPDB Length = 588 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 88/321 (27%), Positives = 152/321 (47%), Gaps = 37/321 (11%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y L+ +G G++G V D + VA+K + + F ++A E+R+L+H++ ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLKKQD 264 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL---GEDRIQFLVYQMLKGLR 142 G ++V E+ + + DL +L+K K ++ +L+ L Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCE--LKILDFGLARQADSEMTGYVVTRWYRAPEVILNW 200 +H IIH DLKP N+ + K++DFG + ++ Y+ +R+YRAPE+IL Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILG- 383 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 RY+ +DIWS GCI+AE++TG+ LF G D DQL +M++ G PP + +++ + + Sbjct: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443 Query: 261 YMKGLPEL---------------------------EKKDFASILTNASP-LAVNLLEKML 292 KG+P KD+ + L L + L++ L Sbjct: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCL 503 Query: 293 VLDAEQRVTAGEALAHPYFES 313 D R+T +AL HP+ Sbjct: 504 HWDPSARLTPAQALRHPWISK 524 >4CZT-A nrPDB Length = 464 Score = 267 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 137/323 (42%), Gaps = 48/323 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAKRAYRELRLLKHMRH 83 Y + +G G + V A + G VAIK + + + RE+ +K ++H Sbjct: 11 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKH 70 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 NVI + +V + T Y V+ F+ G K+ + +L ED + Q++ + Sbjct: 71 PNVIRMFEV------MASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-----QADSEMTGYVVTRWYRAPEV 196 Y H+ G+ HRDLKP NL ++ + LK+ DFGL+ + D + T Y APEV Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 I N D+WS G I+ ++ G F+ S+ K+I K T P F Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF------- 237 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 S A L++++L + R+T E + + +F+ + Sbjct: 238 ------------------------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYK 273 Query: 317 TEDEPQVQKYDDSFDDVDRTLDE 339 P+ + D S DDVD D+ Sbjct: 274 A---PKFENADVSLDDVDAIFDD 293 >5KZ7-A nrPDB Length = 346 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 80/332 (24%), Positives = 144/332 (43%), Gaps = 42/332 (12%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 YR L+ +G G + V A TG +VA+K + + + ++ +RE+R++K + H Sbjct: 33 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 92 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L +V ++TL YLVM + G L+ H ++ E + Q++ ++ Sbjct: 93 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 146 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNW 200 Y H I+HRDLK NL ++ D +KI DFG + + +++ + + Y APE+ Sbjct: 147 YCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGK 206 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 VD+WS+G I+ +++G F G + + + +++ P Sbjct: 207 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM----------- 255 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH-DTED 319 S NLL+K L+L+ +R T + + + H D E Sbjct: 256 --------------------STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDEL 295 Query: 320 EPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSF 351 +P V+ D D L T +E+ Sbjct: 296 KPYVEPLPDYKDPRRTELMVSMGYTREEIQDS 327 >5YKS-A nrPDB Length = 377 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 83/350 (23%), Positives = 146/350 (41%), Gaps = 51/350 (14%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P +GF R K A +Y + +G G + V A TG KVA+K + + Sbjct: 20 PHMAGFKRGYDGKIAG----LYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT 75 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM--KH 122 L ++E+R +K ++H N++ L +V +D T YL++ G D+ + Sbjct: 76 LATGHLFQEVRCMKLVQHPNIVRLYEV------IDTQTKLYLILELGDGGDMFDYIMKHE 129 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGN-LAVNEDCELKILDFGLAR--QAD 179 E L ED + Q++ + Y H ++HRDLKP N + + +K+ DFG + Q Sbjct: 130 EGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG 189 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 ++T + Y APE++L VDIWS+G I+ ++ G+ F+ ++ + L IM Sbjct: 190 KKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM 249 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 T P+ + S +L+ +ML D ++R Sbjct: 250 DCKYTVPS-------------------------------HVSKECKDLITRMLQRDPKRR 278 Query: 300 VTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 + E HP+ + + D KY+ +E + ++ Sbjct: 279 ASLEEIENHPWLQGV----DPSPATKYNIPLVSYKNLSEEEHNSIIQRMV 324 >3GC0-A nrPDB Length = 329 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 100/299 (33%), Positives = 150/299 (50%), Gaps = 18/299 (6%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 YR + +G G YG V A+D T VAIK++ + E A RE+ LLK ++H Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLRY 143 N+I L V + L +L+ + DL K M + I+ +YQ++ G+ + Sbjct: 94 NIIELKSVIHHNHRL------HLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNF 147 Query: 144 IHAAGIIHRDLKPGNLAV-----NEDCELKILDFGLARQAD---SEMTGYVVTRWYRAPE 195 H+ +HRDLKP NL + +E LKI DFGLAR + T ++T WYR PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 ++L Y+ +VDIWS+ CI AEM+ LF G +DQL +I +V G P + + Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA 267 Query: 256 DEAKNYMKGLPELEKKDFASIL-TNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 ++ + P+ K +L ++LL ML +D +R++A AL HPYF Sbjct: 268 --LPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >4NIF-A nrPDB Length = 333 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 94/341 (27%), Positives = 150/341 (43%), Gaps = 54/341 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL-KHMRHEN 85 Y + +G G+Y V T + A+K + + + E+ +L ++ +H N Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE------EIEILLRYGQHPN 63 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 +I L DV+ DD YLV M G L K+++ + E F+++ + K + Y Sbjct: 64 IITLKDVY------DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEY 117 Query: 144 IHAAGIIHRDLKPGNLA-VNEDCE---LKILDFGLARQADSE---MTGYVVTRWYRAPEV 196 +H+ G++HRDLKP N+ V+E L+I DFG A+Q +E + T + APEV Sbjct: 118 LHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEV 177 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + Y + DIWS+G ++ M+ G T F + D +EI+ G+ Sbjct: 178 L-KRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGS------------ 223 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 G L ++ S A +L+ KML +D QR+TA + L HP+ Sbjct: 224 -------GKFTLSGGNW----NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ--- 269 Query: 317 TEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQL 357 + PQ Q V + TY + S KP QL Sbjct: 270 KDKLPQSQLSHQDLQLVKGAM----AATYSALNSSKPTPQL 306 >2JC6-A nrPDB Length = 334 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 74/339 (21%), Positives = 142/339 (41%), Gaps = 44/339 (12%) Query: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY 72 K A +++ ++ + +G+GA+ V A + TG A+K + + + Sbjct: 10 SSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESS-IE 68 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRI 130 E+ +L+ ++HEN++ L D++ + YLVM + G ++++ E Sbjct: 69 NEIAVLRKIKHENIVALEDIY------ESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 122 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQADSE--MTGY 185 L+ Q+L + Y+H GI+HRDLKP NL +E+ ++ I DFGL++ M+ Sbjct: 123 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTA 182 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 T Y APEV+ Y++ VD WS+G I ++ G F + ++I+K Sbjct: 183 CGTPGYVAPEVLA-QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 241 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 + + + S A + + ++ D +R T +A Sbjct: 242 DSPYWD---------------------------DISDSAKDFIRNLMEKDPNKRYTCEQA 274 Query: 306 LAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVT 344 HP+ DT + + + + +W++ Sbjct: 275 ARHPWIAG--DTALNKNIHESVSAQIRKNFAKSKWRQAF 311 >3UTO-A nrPDB Length = 573 Score = 264 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 141/342 (41%), Gaps = 45/342 (13%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 +Y Q V V Y + +G+GA+G V + TG A K + P +S+ + Sbjct: 142 QYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK--E 199 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM--KHEKLG 126 +E++ + +RH ++ L D F +D + ++ FM G +L + + +H K+ Sbjct: 200 TVRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKMS 253 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN--EDCELKILDFGLARQADSEMTG 184 ED + Q+ KGL ++H +H DLKP N+ ELK++DFGL D + + Sbjct: 254 EDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSV 313 Query: 185 YV--VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT 242 V T + APEV D+WSVG + +++G + F G + + L+ + Sbjct: 314 KVTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCD 372 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 S + S + + K+L+ D R+T Sbjct: 373 WNMD---------------------------DSAFSGISEDGKDFIRKLLLADPNTRMTI 405 Query: 303 GEALAHPYFESLHDTEDEPQVQ--KYDDSFDDVDRTLDEWKR 342 +AL HP+ + + Q+ +Y D + D W Sbjct: 406 HQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 447 >2YCR-A nrPDB Length = 323 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 97/358 (27%), Positives = 157/358 (43%), Gaps = 58/358 (16%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA------YRELR 76 +R Y + +GSGA G V A + +T KVAIK + + + A+ A E+ Sbjct: 8 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 67 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLV 134 +LK + H +I + + F D D+Y+V+ M G K++ +++L E + Sbjct: 68 ILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF 120 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSE--MTGYVVTR 189 YQML ++Y+H GIIHRDLKP N+ ++ EDC +KI DFG ++ M T Sbjct: 121 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 180 Query: 190 WYRAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK-EIMKVTGTPP 246 Y APEV+ + Y + VD WS+G I+ ++G F LK +I Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI 240 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 E + S A++L++K+LV+D + R T EAL Sbjct: 241 PE---------------------------VWAEVSEKALDLVKKLLVVDPKARFTTEEAL 273 Query: 307 AHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKE 364 HP+ + DE +K+ D + + + K + + + + G E Sbjct: 274 RHPWLQ------DEDMKRKFQDLLSEENESTA--KPQVLAQPSTSRKRPREGEAEGAE 323 >4CFF-A nrPDB Length = 571 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 88/346 (25%), Positives = 136/346 (39%), Gaps = 48/346 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y +G G +G V TG KVA+K L R +S + RE++ LK RH Sbjct: 33 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 92 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++I L V + TDF++VM ++ G + KH ++ E + L Q+L + Sbjct: 93 PHIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 146 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Y H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + VDIWS G I+ ++ G F K+I P + + + Sbjct: 207 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 262 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 LL ML +D +R T + H +F+ + Sbjct: 263 ---------------------------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 295 Query: 320 EPQVQKYD--DSFDDVDRTLDEWKRVTYKEVLSF----KPPRQLGA 359 P+ YD D+ + + E T EV++ P QL Sbjct: 296 FPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAV 341 >3H4J-B nrPDB Length = 336 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 86/344 (25%), Positives = 145/344 (42%), Gaps = 50/344 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF-AKRAYRELRLLKHMRHEN 85 Y + +G G++G V A +T KVA+K + R + R RE+ LK +RH + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 +I L DV T TD +V+ + G +L +++ +++ ED + Q++ + Y Sbjct: 71 IIKLYDVITTP------TDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMR 202 H I+HRDLKP NL ++++ +KI DFGL+ + + Y APEVI + Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 VD+WS G ++ M+ G+ F + K++ P Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFL------------- 231 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQ 322 SP A +L+ +M+V D QR+T E P+F Sbjct: 232 ------------------SPGAQSLIRRMIVADPMQRITIQEIRRDPWFNV--------N 265 Query: 323 VQKYDDSFDDVDRTLDEWKRVT-YKEVLSFKPPRQLGARVSKET 365 + Y ++V + + + V+ E + F + A S E Sbjct: 266 LPDYLRPMEEVQGSYADSRIVSKLGEAMGFSEDYIVEALRSDEN 309 >5XZW-A nrPDB Length = 471 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 91/331 (27%), Positives = 145/331 (43%), Gaps = 56/331 (16%) Query: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDL----QPVGSGAYGAVCSAVDGRTGAKVAIKKL 58 + A G + +++D + VG GA+ V A++ TG A+K + Sbjct: 170 TSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKII 229 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG 117 + + REL +L+ + H ++ L + +D +Y+VM F+ G DL Sbjct: 230 SK-RKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY------EDTESYYMVMEFVSGGDLM 282 Query: 118 KLMK-HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGL 174 + H +GED + + Q+L ++YIH+ GI HRDLKP N+ + +D +KI DFGL Sbjct: 283 DFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGL 342 Query: 175 AR--QADSEMTGYVVTRWYRAPEVILN------------WMRYTQTVDIWSVGCIMAEMI 220 A+ S M + T Y APEVI Y+ VD+WS+GC++ ++ Sbjct: 343 AKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVIL 402 Query: 221 TGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA 280 TG F GS K+I + + E KDF Sbjct: 403 TGHLPFSGSTQDQLYKQIGRGSYH----------------------EGPLKDFR-----I 435 Query: 281 SPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 S A + ++ +L +D R TA +AL HP+ Sbjct: 436 SEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >5EZV-A nrPDB Length = 560 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 88/346 (25%), Positives = 136/346 (39%), Gaps = 48/346 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y +G G +G V TG KVA+K L R +S + RE++ LK RH Sbjct: 28 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 87 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++I L V + TDF++VM ++ G + KH ++ E + L Q+L + Sbjct: 88 PHIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 141 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Y H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + VDIWS G I+ ++ G F K+I P + + + Sbjct: 202 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 257 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 LL ML +D +R T + H +F+ + Sbjct: 258 ---------------------------LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 290 Query: 320 EPQVQKYD--DSFDDVDRTLDEWKRVTYKEVLSF----KPPRQLGA 359 P+ YD D+ + + E T EV++ P QL Sbjct: 291 FPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAV 336 >3COM-A nrPDB Length = 314 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 139/314 (44%), Gaps = 45/314 (14%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P R + + + V+ L+ +G G+YG+V A+ TG VAIK++ E Sbjct: 10 PPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV----PVE 65 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKL--MKH 122 + +E+ +++ +V+ + + TD ++VM + G + + +++ Sbjct: 66 SDLQEIIKEISIMQQCDSPHVVKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRN 119 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM 182 + L ED I ++ LKGL Y+H IHRD+K GN+ +N + K+ DFG+A Q M Sbjct: 120 KTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 179 Query: 183 ---TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 + T ++ APEVI + Y DIWS+G EM GK + ++ I Sbjct: 180 AKRNTVIGTPFWMAPEVIQE-IGYNCVADIWSLGITAIEMAEGKPPYADIHP---MRAIF 235 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 + PP F PEL +F + +++ LV EQR Sbjct: 236 MIPTNPPPTF--------------RKPELWSDNFT-----------DFVKQCLVKSPEQR 270 Query: 300 VTAGEALAHPYFES 313 TA + L HP+ S Sbjct: 271 ATATQLLQHPFVRS 284 >3ZDU-A nrPDB Length = 325 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 89/293 (30%), Positives = 139/293 (47%), Gaps = 12/293 (4%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 +Y L VG G+YG V TG VAIK Y + + K A RE++ LK HE Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHHE 61 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTD-LGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 N++ L++VF + + +LV F+ L +L + L R++ ++Q+L+ + Sbjct: 62 NLVNLIEVFRQKKKI------HLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 115 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 Y+H+ IIHRD+KP N+ V++ K+ DFG AR V TRWYRAPE++L Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLK 175 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y + VDIW++GC++ EM TG S LD L +I+ G Sbjct: 176 DTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + K+ + L +++ L +D R+++ + L H YF Sbjct: 236 AGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >1KOA-A nrPDB Length = 491 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 141/342 (41%), Gaps = 45/342 (13%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 +Y Q V V Y + +G+GA+G V + TG A K + P +S+ + Sbjct: 36 QYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK--E 93 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM--KHEKLG 126 +E++ + +RH ++ L D F +D + ++ FM G +L + + +H K+ Sbjct: 94 TVRKEIQTMSVLRHPTLVNLHDAF------EDDNEMVMIYEFMSGGELFEKVADEHNKMS 147 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN--EDCELKILDFGLARQADSEMTG 184 ED + Q+ KGL ++H +H DLKP N+ ELK++DFGL D + + Sbjct: 148 EDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSV 207 Query: 185 YV--VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT 242 V T + APEV D+WSVG + +++G + F G + + L+ + Sbjct: 208 KVTTGTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCD 266 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 S + S + + K+L+ D R+T Sbjct: 267 WNMD---------------------------DSAFSGISEDGKDFIRKLLLADPNTRMTI 299 Query: 303 GEALAHPYFESLHDTEDEPQVQ--KYDDSFDDVDRTLDEWKR 342 +AL HP+ + + Q+ +Y D + D W Sbjct: 300 HQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 341 >5KCV-A nrPDB Length = 460 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 86/362 (23%), Positives = 144/362 (39%), Gaps = 58/362 (16%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAV---YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL 58 S P SG EV+ + R + L+ +G G +G V + TG A+K L Sbjct: 136 SGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKIL 195 Query: 59 YRPFQ-SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTD 115 + ++ E R+L++ RH + L F + L VM + G Sbjct: 196 KKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRL------CFVMEYANGGEL 249 Query: 116 LGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVNEDCELKILDFGL 174 L + EDR +F +++ L Y+H+ +++RDLK NL +++D +KI DFGL Sbjct: 250 FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGL 309 Query: 175 ARQA---DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDH 231 ++ + M + T Y APEV+ + Y + VD W +G +M EM+ G+ F DH Sbjct: 310 CKEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 368 Query: 232 LDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKM 291 + I+ P P A +LL + Sbjct: 369 EKLFELILMEEIRFPRTL-------------------------------GPEAKSLLSGL 397 Query: 292 LVLDAEQRV-----TAGEALAHPYF-----ESLHDTEDEPQVQKYDDSFDDVDRTLDEWK 341 L D +QR+ A E + H +F + +++ + P + S D +E+ Sbjct: 398 LKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT 457 Query: 342 RV 343 Sbjct: 458 AQ 459 >5ZTN-A nrPDB Length = 429 Score = 260 bits (665), Expect = 7e-70, Method: Composition-based stats. Identities = 88/330 (26%), Positives = 153/330 (46%), Gaps = 37/330 (11%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 V V Y L+ +G G++G V A D + VA+K + + F ++A E+ Sbjct: 88 VQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNE---KRFHRQAAEEI 144 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL---GEDRIQF 132 R+L+H+R ++ ++V E + + +L +L+K K ++ Sbjct: 145 RILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRK 204 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE--LKILDFGLARQADSEMTGYVVTRW 190 + +L+ L +H IIH DLKP N+ + + +K++DFG + + Y+ +R+ Sbjct: 205 FAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRF 264 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 YRAPEVIL RY +D+WS+GCI+AE++TG L G D DQL ++++ G P + + Sbjct: 265 YRAPEVILG-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL 323 Query: 251 QRLQSDEAKNYMKGLPEL---------------------------EKKDFASILTNA-SP 282 + + KG P E +++ + L P Sbjct: 324 DASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDP 383 Query: 283 LAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 L ++ L++ L D R+T G+AL HP+ Sbjct: 384 LFLDFLKQCLEWDPAVRMTPGQALRHPWLR 413 >4REW-A nrPDB Length = 540 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 84/333 (25%), Positives = 134/333 (40%), Gaps = 44/333 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y +G G +G V TG KVA+K L R +S + RE++ LK RH Sbjct: 6 GHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH 65 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++I L V + +D ++VM ++ G + K+ +L E + L Q+L G+ Sbjct: 66 PHIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 119 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Y H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + VDIWS G I+ ++ G F K+I P Sbjct: 180 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL---------- 229 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 +P ++LL+ ML +D +R + + H +F+ Sbjct: 230 ---------------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYL 268 Query: 320 EPQVQKY--DDSFDDVDRTLDEWKRVTYKEVLS 350 P+ Y D+ + + E + +EVLS Sbjct: 269 FPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 301 >5WAX-A nrPDB Length = 310 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 132/332 (39%), Gaps = 46/332 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y ++ +GSG +G + G VA+K + R E + RE+ + +RH Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIER---GEKIDENVQREIINHRSLRHP 67 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N+I +V T +VM + G ++ + ED +F Q++ G+ Sbjct: 68 NIIRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 121 Query: 143 YIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVIL 198 Y H+ + HRDLK N ++ LKI DFG ++ S+ V T Y APEV+L Sbjct: 122 YCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + D+WS G + M+ G F+ D P F + +Q Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDE--------------PKNFRKTIQRILG 227 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF------E 312 Y +P+ + SP +L+ ++ V + R+T E HP+F + Sbjct: 228 VQY--SIPDY---------VHISPECQDLISRIFVANPATRITIPEIRNHPWFLKNLPAD 276 Query: 313 SLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVT 344 + D+ Q ++ + +D + T Sbjct: 277 LMDDSTMSKQYEEPEQPMQSMDEIMQILAEAT 308 >3D2K-A nrPDB Length = 272 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 138/300 (46%), Gaps = 43/300 (14%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK-RAYREL 75 +K W + + +P+G G +G V A + ++ +A+K L++ + + + RE+ Sbjct: 5 SKRQWTLED-FDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREV 63 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFL 133 + H+RH N++ L F D T YL++ + +GT +L K + E R Sbjct: 64 EIQSHLRHPNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATY 117 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD-SEMTGYVVTRWYR 192 + ++ L Y H+ +IHRD+KP NL + + ELKI DFG + A S T T Y Sbjct: 118 ITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGTLDYL 177 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 PE+I M + + VD+WS+G + E + G F+ + + + I +V T P Sbjct: 178 PPEMIEGRM-HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP------ 230 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 DF + A +L+ ++L +A QR+T E L HP+ + Sbjct: 231 -------------------DF------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >4JG6-A nrPDB Length = 355 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 85/362 (23%), Positives = 147/362 (40%), Gaps = 59/362 (16%) Query: 14 QEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR 73 Q++ + + + Y + +G G+Y + T + A+K + + + Sbjct: 24 QQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE------ 77 Query: 74 ELRLL-KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRI 130 E+ +L ++ +H N+I L DV+ DD Y+V M G L K+++ + E Sbjct: 78 EIEILLRYGQHPNIITLKDVY------DDGKYVYVVTELMKGGELLDKILRQKFFSEREA 131 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLA-VNEDCE---LKILDFGLARQADSE---MT 183 +++ + K + Y+HA G++HRDLKP N+ V+E ++I DFG A+Q +E + Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLM 191 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF---KGSDHLDQLKEIMK 240 T + APEV+ Y DIWS+G ++ M+TG T F + L I Sbjct: 192 TPCYTANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGS 250 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + + + S A +L+ KML +D QR+ Sbjct: 251 GKFSLSGGYWN---------------------------SVSDTAKDLVSKMLHVDPHQRL 283 Query: 301 TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR 360 TA L HP+ Q+ +Y + D + TY + + P Sbjct: 284 TAALVLRHPWIVHWD------QLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVG 337 Query: 361 VS 362 S Sbjct: 338 RS 339 >2JAM-A nrPDB Length = 304 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 132/297 (44%), Gaps = 42/297 (14%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 +R + ++ +GSGA+ V TG A+K + + E+ +LK + Sbjct: 6 NIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK--SPAFRDSSLENEIAVLKKI 63 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 +HEN++ L D++ + T +YLVM + G ++++ E ++ Q+L Sbjct: 64 KHENIVTLEDIY------ESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLS 117 Query: 140 GLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQADSE-MTGYVVTRWYRAPE 195 ++Y+H GI+HRDLKP NL E+ ++ I DFGL++ + M+ T Y APE Sbjct: 118 AVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPE 177 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 V+ Y++ VD WS+G I ++ G F ++I + Sbjct: 178 VLA-QKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKE--------------- 221 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 G E E + I S A + + +L D +R T +AL+HP+ + Sbjct: 222 --------GYYEFESPFWDDI----SESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >4L42-A nrPDB Length = 346 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 86/350 (24%), Positives = 150/350 (42%), Gaps = 59/350 (16%) Query: 16 VTKTAWEVR-AVYRDLQPVGSGAYGAVCSAVDG---RTGAKVAIKKLYRPFQSELFAKRA 71 V + ++R + L+ +G G YG V TG A+K L + A Sbjct: 8 VNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 67 Query: 72 YR--ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGE 127 + E +L+ ++H ++ L+ F L YL++ ++ G +L + E Sbjct: 68 HTKAERNILEEVKHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFME 121 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---G 184 D F + ++ L ++H GII+RDLKP N+ +N +K+ DFGL +++ + T Sbjct: 122 DTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHT 181 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + T Y APE+++ + + VD WS+G +M +M+TG F G + + +I+K Sbjct: 182 FCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 240 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV---- 300 P Q A +LL+K+L +A R+ Sbjct: 241 LPPYLTQ-------------------------------EARDLLKKLLKRNAASRLGAGP 269 Query: 301 -TAGEALAHPYFESLH-----DTEDEPQVQKYDDSFDDVDRTLDEWKRVT 344 AGE AHP+F ++ + EP + S +DV + ++ R T Sbjct: 270 GDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQT 319 >4PDS-A nrPDB Length = 347 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 90/334 (26%), Positives = 147/334 (44%), Gaps = 56/334 (16%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDL----QPVGSGAYGAVCSAVDGRTGAKVAIK 56 M++ A G + +++D + VG GA+ V A++ TG ++K Sbjct: 3 MATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVK 62 Query: 57 KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTD 115 + + + REL +L+ + H ++ L + +D +Y+VM F+ G D Sbjct: 63 IISK-RKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY------EDTESYYMVMEFVSGGD 115 Query: 116 LGKLMK-HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC--ELKILDF 172 L + H +GED + + Q+L ++YIH+ GI HRDLKP N+ + +D +KI F Sbjct: 116 LMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAF 175 Query: 173 GLAR--QADSEMTGYVVTRWYRAPEVILN------------WMRYTQTVDIWSVGCIMAE 218 GLA+ S M + T Y APEVI Y+ VD+WS+GC++ Sbjct: 176 GLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYV 235 Query: 219 MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILT 278 ++TG F GS K+I + + E KDF Sbjct: 236 ILTGHLPFSGSTQDQLYKQIGRGSYH----------------------EGPLKDFR---- 269 Query: 279 NASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S A + ++ +L +D R TA +AL HP+ + Sbjct: 270 -ISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >3I6U-A nrPDB Length = 419 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 93/327 (28%), Positives = 148/327 (45%), Gaps = 56/327 (17%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA------YRELR 76 +R Y + +GSGA G V A + +T KVAI+ + + + A+ A E+ Sbjct: 133 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIE 192 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLV 134 +LK + H +I + + F D D+Y+V+ M G K++ +++L E + Sbjct: 193 ILKKLNHPCIIKIKNFF-------DAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYF 245 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSE--MTGYVVTR 189 YQML ++Y+H GIIHRDLKP N+ ++ EDC +KI DFG ++ M T Sbjct: 246 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 305 Query: 190 WYRAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK-EIMKVTGTPP 246 Y APEV+ + Y + VD WS+G I+ ++G F LK +I Sbjct: 306 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI 365 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 E + S A++L++K+LV+D + R T EAL Sbjct: 366 PE---------------------------VWAEVSEKALDLVKKLLVVDPKARFTTEEAL 398 Query: 307 AHPYFESLHDTEDEPQVQKYDDSFDDV 333 HP+ + DE +K+ D + Sbjct: 399 RHPWLQ------DEDMKRKFQDLLSEE 419 >4CQG-A nrPDB Length = 331 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 136/321 (42%), Gaps = 44/321 (13%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 K E+ Y + +G+G + V A TG VAIK + + R E+ Sbjct: 2 KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLP-RVKTEIDA 60 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVY 135 LK +RH+++ L V L+ ++V+ + G ++ ++L E+ + + Sbjct: 61 LKSLRHQHICQLYHV------LETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFR 114 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA----DSEMTGYVVTRWY 191 Q+L + Y+H+ G HRDLKP NL +E+ +LK++DFGL + D + + Y Sbjct: 115 QILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAY 174 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APE+I D+WS+G ++ ++ G F + + K+IM+ P Sbjct: 175 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWL-- 232 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 SP ++ LL++ML +D ++R++ L HP+ Sbjct: 233 -----------------------------SPSSILLLQQMLQVDPKKRISMRNLLNHPWV 263 Query: 312 ESLHDTEDEPQVQKYDDSFDD 332 + E Q + D+ Sbjct: 264 MQDYSCPVEWQSKTPLTHLDE 284 >3EB0-A nrPDB Length = 383 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 103/334 (30%), Positives = 173/334 (51%), Gaps = 50/334 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y + +G+G++G VC D +G + A+KK+ + + + REL ++K + H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN------RELDIMKVLDHV 60 Query: 85 NVIGLLDVFT--------PDETLDDFTDFY------------------------LVMPFM 112 N+I L+D F P + DD ++M ++ Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 113 GTDLGKLMKH-----EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCE 166 L K++K + + I +YQ+ + + +IH+ GI HRD+KP NL VN +D Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 167 LKILDFGLARQA--DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT 224 LK+ DFG A++ Y+ +R+YRAPE++L YT ++D+WS+GC+ E+I GK Sbjct: 181 LKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKP 240 Query: 225 LFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP-L 283 LF G +DQL I+++ GTP E + R+ + P L+ KD+ IL +P L Sbjct: 241 LFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEV---RFPTLKAKDWRKILPEGTPSL 297 Query: 284 AVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 A++LLE++L + + R+ EA+AHP+F+ L ++ Sbjct: 298 AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNS 331 >4D2V-A nrPDB Length = 356 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 76/328 (23%), Positives = 136/328 (41%), Gaps = 45/328 (13%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 R K E+ Y + +G+G + V A TG VAIK + + R Sbjct: 16 PRGSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLP-RI 74 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDR 129 E+ LK++RH+++ L V L+ ++V+ + G ++ ++L E+ Sbjct: 75 KTEIEALKNLRHQHICQLYHV------LETANKIFMVLEYCPGGELFDYIISQDRLSEEE 128 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA----DSEMTGY 185 + + Q++ + Y+H+ G HRDLKP NL +E +LK++DFGL + D + Sbjct: 129 TRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQAC 188 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 Y APE+I D+WS+G ++ ++ G F + +IM+ Sbjct: 189 CGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDV 248 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 P SP ++ LL++ML +D ++R++ Sbjct: 249 PKWL-------------------------------SPSSILLLQQMLQVDPKKRISMKNL 277 Query: 306 LAHPYFESLHDTEDEPQVQ-KYDDSFDD 332 L HP+ ++ E Q + + DD Sbjct: 278 LNHPWIMQDYNYPVEWQSKNPFIHLDDD 305 >4UZD-A nrPDB Length = 287 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 134/304 (44%), Gaps = 42/304 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK-RAYRELRLLKHMRH 83 + +P+G G +G V A + ++ +A+K L++ + + + RE+ + H+RH Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 N++ L F D T YL++ + +GT +L K K E R + ++ L Sbjct: 68 PNILRLYGYF------HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANAL 121 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD-SEMTGYVVTRWYRAPEVILNW 200 Y H+ +IHRD+KP NL + ELKI DFG + A S T T Y PE+I Sbjct: 122 SYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGR 181 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 M + + VD+WS+G + E + GK F+ + + + K I +V T P Sbjct: 182 M-HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFP-------------- 226 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 DF + A +L+ ++L + QR E L HP+ + Sbjct: 227 -----------DF------VTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSN 269 Query: 321 PQVQ 324 Q + Sbjct: 270 CQNK 273 >3F3Z-A nrPDB Length = 277 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 133/304 (43%), Gaps = 44/304 (14%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 T ++ Y +G G++G V AV T + A KK+ + F ++ R +E+ Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD--RFKQEIE 58 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLV 134 ++K + H N+I L ET +D TD YLVM G +++ E ++ Sbjct: 59 IMKSLDHPNIIRLY------ETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIM 112 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQADSE--MTGYVVTR 189 +L + Y H + HRDLKP N + D LK++DFGLA + M V T Sbjct: 113 KDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTP 172 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 +Y +P+V+ Y D WS G +M ++ G F + + +I + T T P Sbjct: 173 YYVSPQVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPE-- 228 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 KD+ N SP A +L+ ++L +QR+T+ +AL H Sbjct: 229 ---------------------KDWL----NVSPQAESLIRRLLTKSPKQRITSLQALEHE 263 Query: 310 YFES 313 +FE Sbjct: 264 WFEK 267 >2J90-A nrPDB Length = 304 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 80/326 (24%), Positives = 141/326 (43%), Gaps = 52/326 (15%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q + V Y + +GSG + V TG + A K + + Sbjct: 9 SGVDLGTENLYFQSM------VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKR 62 Query: 62 FQSE----LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTD 115 S + + RE+ +L+ +RH N+I L D+F ++ TD L++ + G Sbjct: 63 RLSSSRRGVSREEIEREVNILREIRHPNIITLHDIF------ENKTDVVLILELVSGGEL 116 Query: 116 LGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE----DCELKILD 171 L + E L ED + Q+L G+ Y+H+ I H DLKP N+ + + + +K++D Sbjct: 117 FDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLID 176 Query: 172 FGLARQA--DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 FG+A + +E T + APE I+N+ D+WS+G I +++G + F G Sbjct: 177 FGIAHKIEAGNEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGE 235 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 + L I V E+ +N S LA + + Sbjct: 236 TKQETLTNISAVNYDFDEEY---------------------------FSNTSELAKDFIR 268 Query: 290 KMLVLDAEQRVTAGEALAHPYFESLH 315 ++LV D ++R+T ++L H + +++ Sbjct: 269 RLLVKDPKRRMTIAQSLEHSWIKAIR 294 >6FD3-A nrPDB Length = 300 Score = 256 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 140/298 (46%), Gaps = 41/298 (13%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 + + + Y + +G GA G V +A+D TG +VAIK++ Q + + E+ ++ Sbjct: 16 SVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKELIINEILVM 73 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQM 137 + ++ N++ LD + + + ++VM ++ G L ++ + E +I + + Sbjct: 74 RENKNPNIVNYLDSYLVGD------ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCREC 127 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAP 194 L+ L ++H+ +IHRD+K N+ + D +K+ DFG Q S+ + V T ++ AP Sbjct: 128 LQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 187 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ Y VDIWS+G + EM+ G+ + + L L I GTP + +RL Sbjct: 188 EVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTPELQNPERL- 244 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S + + L + L +D ++R +A E L HP+ + Sbjct: 245 --------------------------SAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >4LG4-A nrPDB Length = 299 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 136/300 (45%), Gaps = 45/300 (15%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 + V+ L+ +G G+YG+V A+ +G VAIK++ E + +E+ +++ Sbjct: 6 TKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV----PVESDLQEIIKEISIMQ 61 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKL--MKHEKLGEDRIQFLVYQ 136 V+ + + TD ++VM + G + + ++++ L ED I ++ Sbjct: 62 QCDSPYVVKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS 115 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRA 193 LKGL Y+H IHR++K GN+ +N + K+ DFG+A Q M + T ++ A Sbjct: 116 TLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMA 175 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PEVI + Y DIWS+G EM GK + ++ I + PP F Sbjct: 176 PEVIQE-IGYNCVADIWSLGITSIEMAEGKPPYADIHP---MRAIFMIPTNPPPTF---- 227 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 PEL DF + ++K LV + EQR TA + L HP+ ++ Sbjct: 228 ----------RKPELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN 266 >4RED-A nrPDB Length = 351 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 83/333 (24%), Positives = 133/333 (39%), Gaps = 44/333 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y +G G +G V TG VA+K L R +S + RE++ LK RH Sbjct: 14 GHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH 73 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++I L V + +D ++VM ++ G + K+ +L E + L Q+L G+ Sbjct: 74 PHIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 127 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Y H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + VDIWS G I+ ++ G F K+I P Sbjct: 188 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL---------- 237 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 +P ++LL+ ML +D +R + + H +F+ Sbjct: 238 ---------------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYL 276 Query: 320 EPQVQKY--DDSFDDVDRTLDEWKRVTYKEVLS 350 P+ Y D+ + + E + +EVLS Sbjct: 277 FPEDPSYSTTMIDDEALKEVCEKFECSEEEVLS 309 >3MV5-A nrPDB Length = 342 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 82/347 (23%), Positives = 142/347 (40%), Gaps = 59/347 (17%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ-SELFAKRAYRELRLLKHMRHEN 85 + L+ +G G +G V + TG A+K L + ++ E R+L++ RH Sbjct: 12 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 71 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + L F + L VM + G L + EDR +F +++ L Y Sbjct: 72 LTALKYSFQTHDRL------CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 144 IHA-AGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 +H+ +++RDLK NL +++D +KI DFGL ++ + M + T Y APEV+ + Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED 185 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y + VD W +G +M EM+ G+ F DH + I+ P Sbjct: 186 N-DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTL---------- 234 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYF--- 311 P A +LL +L D +QR+ A E + H +F Sbjct: 235 ---------------------GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 273 Query: 312 --ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 + +++ + P + S D +E+ ++++ PP Q Sbjct: 274 VWQHVYEKKLSPPFKPQVTSETDTRYFDEEFT----AQMITITPPDQ 316 >2HAK-A nrPDB Length = 328 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 133/315 (42%), Gaps = 41/315 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 YR + +G G + V A TG +VA+K + + + ++ +RE+R++K + H Sbjct: 15 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 74 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L +V ++TL YLVM + G L+ H ++ E + Q++ ++ Sbjct: 75 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 128 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNW 200 Y H I+HRDLK NL ++ D +KI DFG + + +++ + + Y APE+ Sbjct: 129 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGK 188 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 VD+WS+G I+ +++G F G + + + +++ P ++ K Sbjct: 189 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKL 248 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 + +R + + + + H+ E+ Sbjct: 249 LVLN-------------------------------PIKRGSLEQIMKDRWMNVGHEEEEL 277 Query: 321 PQVQKYDDSFDDVDR 335 + D F+D R Sbjct: 278 KPYTEPDPDFNDTKR 292 >4CFH-A nrPDB Length = 493 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 85/333 (25%), Positives = 134/333 (40%), Gaps = 44/333 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y +G G +G V TG KVA+K L R +S + RE++ LK RH Sbjct: 33 GHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH 92 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++I L V + +D ++VM ++ G + K+ +L E + L Q+L G+ Sbjct: 93 PHIIKLYQVISTP------SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGV 146 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Y H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI Sbjct: 147 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + VDIWS G I+ ++ G F K+I P Sbjct: 207 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYL---------- 256 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 +P ++LL+ ML +D +R T + H +F+ Sbjct: 257 ---------------------NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYL 295 Query: 320 EPQVQKY--DDSFDDVDRTLDEWKRVTYKEVLS 350 P+ Y D+ + + E + +EVLS Sbjct: 296 FPEDPSYSSTMIDDEALKEVCEKFECSEEEVLS 328 >3TAC-A nrPDB Length = 361 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 89/371 (23%), Positives = 151/371 (40%), Gaps = 72/371 (19%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL---YRPFQSELFAKRAYRELRLLKH 80 VY + +G G + V ++ TG + A+K + L + RE + Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEK----LGEDRIQFLV 134 ++H +++ LL+ ++ D L Y+V FM G DL +++K E + Sbjct: 85 LKHPHIVELLETYSSDGML------YMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYM 138 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSE---MTGYVVT 188 Q+L+ LRY H IIHRD+KP + + +K+ FG+A Q G V T Sbjct: 139 RQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGT 198 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE 248 + APEV+ Y + VD+W G I+ +++G F G+ Sbjct: 199 PHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKER---------------- 241 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 + +KG ++ + ++ I S A +L+ +ML+LD +R+T EAL H Sbjct: 242 --------LFEGIIKGKYKMNPRQWSHI----SESAKDLVRRMLMLDPAERITVYEALNH 289 Query: 309 PYFES-------LHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK-------PP 354 P+ + +H E Q++K++ + K V S K PP Sbjct: 290 PWLKERDRYAYKIHLPETVEQLRKFNARR--------KLKGAVLAAVSSHKFNSFYGDPP 341 Query: 355 RQLGARVSKET 365 +L T Sbjct: 342 EELPDFSEDPT 352 >6C9D-A nrPDB Length = 459 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 133/315 (42%), Gaps = 41/315 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 YR + +G G + V A TG +VA+K + + + ++ +RE+R++K + H Sbjct: 21 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 80 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ L +V ++TL YLVM + G L+ H ++ E + Q++ ++ Sbjct: 81 NIVKLFEVIETEKTL------YLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 134 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNW 200 Y H I+HRDLK NL ++ D +KI DFG + + +++ + + Y APE+ Sbjct: 135 YCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGK 194 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 VD+WS+G I+ +++G F G + + + +++ P ++ K Sbjct: 195 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKL 254 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 + +R + + + + H+ E+ Sbjct: 255 LVLN-------------------------------PIKRGSLEQIMKDRWMNVGHEEEEL 283 Query: 321 PQVQKYDDSFDDVDR 335 + D F+D R Sbjct: 284 KPYTEPDPDFNDTKR 298 >6AO5-A nrPDB Length = 362 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 136/300 (45%), Gaps = 45/300 (15%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 + V+ L+ +G G+YG+V A+ +G VAIK++ E + +E+ +++ Sbjct: 5 TKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV----PVESDLQEIIKEISIMQ 60 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKL--MKHEKLGEDRIQFLVYQ 136 V+ + + TD ++VM + G + + ++++ L ED I ++ Sbjct: 61 QCDSPYVVKYYGSYFKN------TDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS 114 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRA 193 LKGL Y+H IHR++K GN+ +N + K+ DFG+A Q M + T ++ A Sbjct: 115 TLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMA 174 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PEVI + Y DIWS+G EM GK + ++ I + PP F Sbjct: 175 PEVIQE-IGYNCVADIWSLGITSIEMAEGKPPYADIHP---MRAIFMIPTNPPPTF---- 226 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 PEL DF + ++K LV + EQR TA + L HP+ ++ Sbjct: 227 ----------RKPELWSDDFT-----------DFVKKCLVKNPEQRATATQLLQHPFIKN 265 >2HW6-A nrPDB Length = 307 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 86/314 (27%), Positives = 142/314 (45%), Gaps = 41/314 (13%) Query: 20 AWEVRAVYRDL-QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 + +Y+ + +G GAY V AV + G + A+K + + Q+ R +RE+ L Sbjct: 7 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK--QAGHSRSRVFREVETL 64 Query: 79 KHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVY 135 + ++N++ L++ F +D T FYLV + G+ L + K + E +V Sbjct: 65 YQCQGNKNILELIEFF------EDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVR 118 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNED---CELKILDFGLARQA----------DSEM 182 + L ++H GI HRDLKP N+ +KI DF L E+ Sbjct: 119 DVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPEL 178 Query: 183 TGYVVTRWYRAPEVIL----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEI 238 T + Y APEV+ Y + D+WS+G ++ M++G F G D Sbjct: 179 TTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD----- 233 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 G E + Q+ ++ +G E KD+A I S A +L+ K+LV DA+Q Sbjct: 234 ---CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRDAKQ 286 Query: 299 RVTAGEALAHPYFE 312 R++A + L HP+ + Sbjct: 287 RLSAAQVLQHPWVQ 300 >3E3P-A nrPDB Length = 360 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 97/312 (31%), Positives = 157/312 (50%), Gaps = 23/312 (7%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 ++ + G G +G V + TG VAIKK+ Q F R + ++ L + H Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHP 79 Query: 85 NVIGLLDVFTPDETLDDFTDFYL--VMPFMGTDLGKLMKHEKL-----GEDRIQFLVYQM 137 N++ L F D D YL VM ++ L + ++ I+ ++Q+ Sbjct: 80 NIVQLQSYFYTLGE-RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQL 138 Query: 138 LKGLRYIH--AAGIIHRDLKPGNLAVNE-DCELKILDFGLARQADSEMTG--YVVTRWYR 192 ++ + +H + + HRD+KP N+ VNE D LK+ DFG A++ Y+ +R+YR Sbjct: 139 IRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYR 198 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 APE+I YT VDIWSVGCI AEM+ G+ +F+G + QL EI++V G P E +++ Sbjct: 199 APELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLRK 258 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNAS----PLAVNLLEKMLVLDAEQRVTAGEALAH 308 L + L + ++++ ++ S A +LL +L E+R+ EAL H Sbjct: 259 LNP---SHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCH 315 Query: 309 PYFESLHDTEDE 320 PYF+ LHD + Sbjct: 316 PYFDELHDPATK 327 >2Y7J-A nrPDB Length = 365 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 79/332 (23%), Positives = 138/332 (41%), Gaps = 57/332 (17%) Query: 5 PPARSGFYRQEVTK--------TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIK 56 P Y Q + A E Y +G G V V TG + A+K Sbjct: 66 PKGTENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVK 125 Query: 57 KL------YRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVM 109 + P Q E + RE +L+ + H ++I L+D + + + +LV Sbjct: 126 IMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSY------ESSSFMFLVF 179 Query: 110 PFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL 167 M G L + L E + ++ +L+ + ++HA I+HRDLKP N+ ++++ ++ Sbjct: 180 DLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQI 239 Query: 168 KILDFGLARQA--DSEMTGYVVTRWYRAPEVILNWM-----RYTQTVDIWSVGCIMAEMI 220 ++ DFG + ++ T Y APE++ M Y + VD+W+ G I+ ++ Sbjct: 240 RLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLL 299 Query: 221 TGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA 280 G F + L+ IM+ Y PE + + Sbjct: 300 AGSPPFWHRRQILMLRMIME------------------GQYQFSSPEWDDR--------- 332 Query: 281 SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S +L+ ++L +D E R+TA +AL HP+FE Sbjct: 333 SSTVKDLISRLLQVDPEARLTAEQALQHPFFE 364 >5JZN-A nrPDB Length = 280 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 79/312 (25%), Positives = 134/312 (42%), Gaps = 47/312 (15%) Query: 14 QEVTKTAWEVR----AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 +EV++ +++ Y+ + +G G + V V+ T + A+K + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEH- 62 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LMKHEKLGE 127 E+ +L+ ++H N++ L+ E +D T+ YLVM + G DL + K E Sbjct: 63 MIQNEVSILRRVKHPNIVLLI------EEMDVPTELYLVMELVKGGDLFDAITSTNKYTE 116 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV----NEDCELKILDFGLARQADSEMT 183 ++Y + ++Y+H+ I+HRD+KP NL V + LK+ DFGLA D + Sbjct: 117 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLY 176 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK--GSDHLDQLKEIMKV 241 T Y APE+I Y VDIW+ G I ++ G F+ G D +I+ Sbjct: 177 TVCGTPTYVAPEIIAE-TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMG 235 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 P+ + N S A L+ ML++D +QR + Sbjct: 236 QVDFPSPYWD---------------------------NVSDSAKELITMMLLVDVDQRFS 268 Query: 302 AGEALAHPYFES 313 A + L HP+ Sbjct: 269 AVQVLEHPWVND 280 >3GUB-A nrPDB Length = 295 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 140/322 (43%), Gaps = 52/322 (16%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE----LFAKRAYRELRL 77 V Y + +GSG + V + TG + A K + + + + RE+ + Sbjct: 8 NVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVY 135 LK ++H NVI L +V+ ++ TD L+ + G L + E L E+ + Sbjct: 68 LKEIQHPNVITLHEVY------ENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLK 121 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDC----ELKILDFGLARQAD--SEMTGYVVTR 189 Q+L G+ Y+H+ I H DLKP N+ + + +KI+DFGLA + D +E T Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTP 181 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 + APE I+N+ D+WS+G I +++G + F G + L + V E+ Sbjct: 182 EFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 +N S LA + + ++LV D ++R+T ++L HP Sbjct: 241 ---------------------------FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHP 273 Query: 310 YFES------LHDTEDEPQVQK 325 + + L PQ +K Sbjct: 274 WIKPKDTQQALSSAWSHPQFEK 295 >3ZUT-A nrPDB Length = 362 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 127/337 (37%), Gaps = 54/337 (16%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y ++ +GSG +G D ++ VA+K + R E + RE+ + +RH Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIER---GEKIDENVKREIINHRSLRHP 75 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ +V T +VM + G ++ + ED +F Q++ G+ Sbjct: 76 NIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 Query: 143 YIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVIL 198 Y HA + HRDLK N ++ LKI FG ++ S+ V T Y APEV+L Sbjct: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDH----LDQLKEIMKVTGTPPAEFVQRLQ 254 + D+WS G + M+ G F+ + + I+ V P Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD------- 242 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF--- 311 + SP +L+ ++ V D +R++ E H +F Sbjct: 243 ----------------------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 Query: 312 ---ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTY 345 + ++D Q + D ++ + T Sbjct: 281 LPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 >2YZA-A nrPDB Length = 276 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 77/294 (26%), Positives = 118/294 (40%), Gaps = 42/294 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y +G G +G V TG KVA+K L R +S + RE++ LK RH Sbjct: 11 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 70 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++I L V + TDF++VM ++ G + KH ++ E + L Q+L + Sbjct: 71 PHIIKLYQVISTP------TDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAV 124 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILN 199 Y H ++HRDLKP N+ ++ KI DFGL+ + + Y APEVI Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + VDIWS G I+ ++ G F K+I P + + + Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 240 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 LL ML +D +R T + H +F+ Sbjct: 241 ---------------------------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >2YAB-A nrPDB Length = 361 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 132/305 (43%), Gaps = 46/305 (15%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA----KRAYRELRL 77 +V Y + +GSG + V + TG + A K + + + RE+ + Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSI 68 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVY 135 L+ + H N+I L DV+ ++ TD L++ + G L + E L E+ + Sbjct: 69 LRQVLHPNIITLHDVY------ENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIK 122 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDC----ELKILDFGLARQADS--EMTGYVVTR 189 Q+L G+ Y+H I H DLKP N+ + + +K++DFGLA + + E T Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 + APE I+N+ D+WS+G I +++G + F G + L I V+ EF Sbjct: 183 EFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 + S LA + + K+LV + +R+T EAL HP Sbjct: 242 ---------------------------FSQTSELAKDFIRKLLVKETRKRLTIQEALRHP 274 Query: 310 YFESL 314 + + Sbjct: 275 WITPV 279 >3UC3-A nrPDB Length = 361 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 132/342 (38%), Gaps = 54/342 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y ++ +GSG +G D T VA+K + R + RE+ + +RH Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIER---GAAIDENVQREIINHRSLRHP 76 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ +V T ++M + G ++ + ED +F Q+L G+ Sbjct: 77 NIVRFKEVILTP------THLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVS 130 Query: 143 YIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVIL 198 Y H+ I HRDLK N ++ LKI DFG ++ S+ V T Y APEV+L Sbjct: 131 YCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKG----SDHLDQLKEIMKVTGTPPAEFVQRLQ 254 + D+WS G + M+ G F+ D+ ++ I+ V + P + Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI----- 245 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF--- 311 SP +L+ ++ V D R++ E H +F Sbjct: 246 ------------------------RISPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 Query: 312 ---ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS 350 + ++++ Q Q+ + +D + T V + Sbjct: 282 LPADLMNESNTGSQFQEPEQPMQSLDTIMQIISEATIPAVRN 323 >1PHK-A nrPDB Length = 298 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 134/307 (43%), Gaps = 50/307 (16%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-------YRPFQSELFAKRAYRELRL 77 Y + +G G V + T + A+K + + + + + +E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 78 LKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLV 134 L+ + H N+I L D + + T F+LV M G L + L E + ++ Sbjct: 77 LRKVSGHPNIIQLKDTYETN------TFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIM 130 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD--SEMTGYVVTRWYR 192 +L+ + +H I+HRDLKP N+ +++D +K+ DFG + Q D ++ T Y Sbjct: 131 RALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYL 190 Query: 193 APEVIL-----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 APE+I N Y + VD+WS G IM ++ G F + L+ IM Sbjct: 191 APEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM-------- 242 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + NY G PE + + S +L+ + LV+ ++R TA EALA Sbjct: 243 ----------SGNYQFGSPEWD---------DYSDTVKDLVSRFLVVQPQKRYTAEEALA 283 Query: 308 HPYFESL 314 HP+F+ Sbjct: 284 HPFFQQY 290 >4D28-A nrPDB Length = 446 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 71/326 (21%), Positives = 129/326 (39%), Gaps = 52/326 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 Y + +G G + V A + TG VAIK + + + RE+ ++K +RH Sbjct: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRH 68 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 N++ L +V L + Y+V+ F+ G +++ +L ED + Q++ + Sbjct: 69 PNIVRLYEV------LASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAV 122 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSEMTGYVVTRWYRAPEVIL 198 + H+ G+ HRDLKP NL ++ + LK+ DFGL+ ++ + T Y APEV+ Sbjct: 123 AHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS 182 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 DIWS G I+ ++ G F +D ++I P F Sbjct: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWF--------- 233 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 S L+ ++L + + R+ P+F + Sbjct: 234 ----------------------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP- 270 Query: 319 DEPQVQKYDDSFDDVDRTLDEWKRVT 344 + ++ + LD+ + V Sbjct: 271 --------IRAREEEEVNLDDIRAVF 288 >2JDO-A nrPDB Length = 342 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 81/346 (23%), Positives = 140/346 (40%), Gaps = 58/346 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRHEN 85 + L+ +G G +G V + TG A+K L + ++ E R+L++ RH Sbjct: 12 FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF 71 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + L F + L VM + G L + E+R +F +++ L Y Sbjct: 72 LTALKYAFQTHDRL------CFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNW 200 +H+ +++RD+K NL +++D +KI DFGL ++ + M + T Y APEV+ + Sbjct: 126 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN 185 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y + VD W +G +M EM+ G+ F DH + I+ P Sbjct: 186 -DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTL----------- 233 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYF---- 311 SP A +LL +L D +QR+ A E + H +F Sbjct: 234 --------------------SPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSIN 273 Query: 312 -ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 + + + P + S D DE+ + ++ PP + Sbjct: 274 WQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT----AQSITITPPDR 315 >5D7A-A nrPDB Length = 308 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 81/324 (25%), Positives = 131/324 (40%), Gaps = 47/324 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RH 83 ++ ++ VG+G YG V +TG AIK + E + +E+ +LK H Sbjct: 17 GIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHH 73 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLK 139 N+ F +LVM F G TDL K K L E+ I ++ ++L+ Sbjct: 74 RNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILR 133 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEMTGYVVTRWYRAPEV 196 GL ++H +IHRD+K N+ + E+ E+K++DFG++ Q D ++ T ++ APEV Sbjct: 134 GLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 193 Query: 197 ILNWMR----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 I Y D+WS+G EM G + L I + Sbjct: 194 IACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR------------ 241 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 P L+ K + S + +E LV + QR + + HP+ Sbjct: 242 ----------NPAPRLKSKKW-------SKKFQSFIESCLVKNHSQRPATEQLMKHPFI- 283 Query: 313 SLHDTEDEPQVQKYDDSFDDVDRT 336 D +E QV+ D + Sbjct: 284 --RDQPNERQVRIQLKDHIDRTKK 305 >3UDB-A nrPDB Length = 317 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 127/337 (37%), Gaps = 54/337 (16%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y ++ +G+G +G D + VA+K + R E + RE+ + +RH Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIER---GEKIDENVKREIINHRSLRHP 75 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 N++ +V T +VM + G ++ + ED +F Q++ G+ Sbjct: 76 NIVRFKEVILTP------THLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVS 129 Query: 143 YIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVIL 198 Y HA + HRDLK N ++ LKI DFG ++ S+ V T Y APEV+L Sbjct: 130 YAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLL 189 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDH----LDQLKEIMKVTGTPPAEFVQRLQ 254 + D+WS G + M+ G F+ + + I+ V P Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPD------- 242 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF--- 311 + SP +L+ ++ V D +R++ E H +F Sbjct: 243 ----------------------YVHISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 Query: 312 ---ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTY 345 + ++D Q + D ++ + T Sbjct: 281 LPADLMNDNTMTTQFDESDQPGQSIEEIMQIIAEATV 317 >4RLP-A nrPDB Length = 288 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 136/323 (42%), Gaps = 58/323 (17%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDG---RTGAKVAIKKLYRPFQSELFAKRAYR--ELRLL 78 + L+ +G G YG V TG A+K L + A+ E +L Sbjct: 4 PECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNIL 63 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQ 136 + ++H ++ L+ F L YL++ ++ G +L + ED F + + Sbjct: 64 EEVKHPFIVDLIYAFQTGGKL------YLILEYLSGGELFMQLEREGIFMEDTACFYLAE 117 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRA 193 + L ++H GII+RDLKP N+ +N +K+ DFGL +++ + T + T Y A Sbjct: 118 ISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMA 177 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PE+++ + + VD WS+G +M +M+TG F G + + +I+K P Q Sbjct: 178 PEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ-- 234 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAH 308 A +LL+K+L +A R+ AGE AH Sbjct: 235 -----------------------------EARDLLKKLLKRNAASRLGAGPGDAGEVQAH 265 Query: 309 PYFESLH-----DTEDEPQVQKY 326 P+F ++ + EP + Sbjct: 266 PFFRHINWEELLARKVEPPFKPL 288 >2A27-A nrPDB Length = 321 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 81/324 (25%), Positives = 138/324 (42%), Gaps = 53/324 (16%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE- 65 F +Q +V Y + +GSG + V + TG + A K + + Sbjct: 1 GMEPFKQQ-------KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRAS 53 Query: 66 ---LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM 120 + + RE+ +L+ + H NVI L DV+ ++ TD L++ + G L Sbjct: 54 RRGVSREEIEREVSILRQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLA 107 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC----ELKILDFGLAR 176 + E L E+ + Q+L G+ Y+H I H DLKP N+ + + +K++DFGLA Sbjct: 108 QKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAH 167 Query: 177 QADS--EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 + + E T + APE I+N+ D+WS+G I +++G + F G + Sbjct: 168 EIEDGVEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQET 226 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 L I V+ EF + S LA + + K+LV Sbjct: 227 LANITAVSYDFDEEF---------------------------FSQTSELAKDFIRKLLVK 259 Query: 295 DAEQRVTAGEALAHPYFESLHDTE 318 + +R+T EAL HP+ + + + Sbjct: 260 ETRKRLTIQEALRHPWITPVDNQQ 283 >2F57-A nrPDB Length = 317 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 138/302 (45%), Gaps = 41/302 (13%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 ++ + + R + +G G+ G VC A + TG +VA+KK+ + + + + E Sbjct: 35 QLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM--DLRKQQRRELLFNE 92 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFL 133 + +++ H+NV+ + + + + ++VM F+ G L ++ H ++ E++I + Sbjct: 93 VVIMRDYHHDNVVDMYSSYLVGD------ELWVVMEFLEGGALTDIVTHTRMNEEQIATV 146 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRW 190 +L+ L Y+H G+IHRD+K ++ + D +K+ DFG Q E+ V T + Sbjct: 147 CLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPY 206 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + APEVI + + Y VDIWS+G ++ EMI G+ + L ++ I Sbjct: 207 WMAPEVI-SRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL-------- 257 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 L S + L+ MLV + QR TA E L HP+ Sbjct: 258 --------------------PPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPF 297 Query: 311 FE 312 + Sbjct: 298 LK 299 >3IS5-A nrPDB Length = 285 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 87/319 (27%), Positives = 147/319 (46%), Gaps = 54/319 (16%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q + ++ + +GSGA+G V + +G + IK + + +S+ Sbjct: 9 SGRENLYFQG------TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQ 61 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM--- 120 + ++ E+ +LK + H N+I + +VF +D+ + Y+VM G L +++ Sbjct: 62 VPMEQIEAEIEVLKSLDHPNIIKIFEVF------EDYHNMYIVMETCEGGELLERIVSAQ 115 Query: 121 -KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGLAR 176 + + L E + L+ QM+ L Y H+ ++H+DLKP N+ + +KI+DFGLA Sbjct: 116 ARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAE 175 Query: 177 --QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 ++D T T Y APEV + T DIWS G +M ++TG F Sbjct: 176 LFKSDEHSTNAAGTALYMAPEVFKRDV--TFKCDIWSAGVVMYFLLTGCLPF-------- 225 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 TGT E Q+ E ++ P +P AV+LL++ML Sbjct: 226 -------TGTSLEEVQQKATYKEPNYAVECRP-------------LTPQAVDLLKQMLTK 265 Query: 295 DAEQRVTAGEALAHPYFES 313 D E+R +A + L H +F+ Sbjct: 266 DPERRPSAAQVLHHEWFKQ 284 >1ZWS-A nrPDB Length = 288 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 81/324 (25%), Positives = 139/324 (42%), Gaps = 53/324 (16%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE- 65 F +Q +V Y + +GSG + V + TG + A K + + Sbjct: 1 GMEPFKQQ-------KVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRAS 53 Query: 66 ---LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM 120 + + RE+ +L+ + H NVI L DV+ ++ TD L++ + G L Sbjct: 54 RRGVSREEIEREVSILRQVLHHNVITLHDVY------ENRTDVVLILELVSGGELFDFLA 107 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC----ELKILDFGLAR 176 + E L E+ + Q+L G+ Y+H I H DLKP N+ + + +K++DFGLA Sbjct: 108 QKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAH 167 Query: 177 QADS--EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 + + E T + APE I+N+ D+WS+G I +++G + F G + Sbjct: 168 EIEDGVEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQET 226 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 L I V+ EF ++ S LA + + K+LV Sbjct: 227 LANITSVSYDFDEEF---------------------------FSHTSELAKDFIRKLLVK 259 Query: 295 DAEQRVTAGEALAHPYFESLHDTE 318 + +R+T EAL HP+ + + + Sbjct: 260 ETRKRLTIQEALRHPWITPVDNQQ 283 >6CKI-A nrPDB Length = 316 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 85/319 (26%), Positives = 136/319 (42%), Gaps = 41/319 (12%) Query: 24 RAVYRDLQ-PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 VY+ + +G GA+ V + ++ T + A+K + + Q R +RE+ +L + Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEK--QPGHIRSRVFREVEMLYQCQ 68 Query: 83 -HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLK 139 H N V E ++ FYLV M G+ L + K E +V + Sbjct: 69 GHRN------VLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVAS 122 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQA----------DSEMTGYV 186 L ++H GI HRDLKP N+ + +KI DFGL E+ Sbjct: 123 ALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPC 182 Query: 187 VTRWYRAPEVILNWMR----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT 242 + Y APEV+ + Y + D+WS+G I+ +++G F G D Sbjct: 183 GSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------C 234 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 G E Q+ ++ +G E KD+A I S A +L+ K+LV DA+QR++A Sbjct: 235 GWDRGEACPACQNMLFESIQEGKYEFPDKDWAHI----SCAAKDLISKLLVRDAKQRLSA 290 Query: 303 GEALAHPYFESLHDTEDEP 321 + L HP+ + P Sbjct: 291 AQVLQHPWVQGCAPENTLP 309 >3Q53-A nrPDB Length = 306 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 139/298 (46%), Gaps = 41/298 (13%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 + + + Y + +G GA G V +A+D TG +VAI+++ Q + + E+ ++ Sbjct: 15 SVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKELIINEILVM 72 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQM 137 + ++ N++ LD + + + ++VM ++ G L ++ + E +I + + Sbjct: 73 RENKNPNIVNYLDSYLVGD------ELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCREC 126 Query: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAP 194 L+ L ++H+ +IHRD+K N+ + D +K+ DFG Q S+ + V T ++ AP Sbjct: 127 LQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 186 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV+ Y VDIWS+G + EMI G+ + + L L I GTP + ++L Sbjct: 187 EVV-TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEKL- 243 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S + + L + L +D E+R +A E + H + + Sbjct: 244 --------------------------SAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >2W4O-A nrPDB Length = 349 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 133/341 (39%), Gaps = 53/341 (15%) Query: 2 SSPPPARSGFYRQEV--TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY 59 +S P + + + +G GA V T A+K L Sbjct: 28 ASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK 87 Query: 60 RPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLG 117 + ++ E+ +L + H N+I L ++F T+ LV+ + G Sbjct: 88 KTVDKKIVR----TEIGVLLRLSHPNIIKLKEIFETP------TEISLVLELVTGGELFD 137 Query: 118 KLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCELKILDFGL 174 ++++ E V Q+L+ + Y+H GI+HRDLKP NL D LKI DFGL Sbjct: 138 RIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGL 197 Query: 175 ARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHL 232 ++ + + M T Y APE++ Y VD+WSVG I ++ G F Sbjct: 198 SKIVEHQVLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGIITYILLCGFEPFYDERGD 256 Query: 233 D-QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKM 291 + I+ + + S A +L+ K+ Sbjct: 257 QFMFRRILNCEYYFISPWWD---------------------------EVSLNAKDLVRKL 289 Query: 292 LVLDAEQRVTAGEALAHPYFES-----LHDTEDEPQVQKYD 327 +VLD ++R+T +AL HP+ +H + ++Q+++ Sbjct: 290 IVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFN 330 >4FIE-A nrPDB Length = 423 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 41/301 (13%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 ++ + R+ + +G G+ G VC A +G VA+KK+ + + + + E Sbjct: 141 QLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNE 198 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFL 133 + +++ +HENV+ + + + + + ++VM F+ G L ++ H ++ E++I + Sbjct: 199 VVIMRDYQHENVVEMYNSYLVGD------ELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 252 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRW 190 +L+ L +HA G+IHRD+K ++ + D +K+ DFG Q E+ V T + Sbjct: 253 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 312 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + APE+I + + Y VDIWS+G ++ EM+ G+ + L +K I Sbjct: 313 WMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---------- 361 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 LP K L SP L+++LV D QR TA E L HP+ Sbjct: 362 -------------NLPPRLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 403 Query: 311 F 311 Sbjct: 404 L 404 >4KS7-A nrPDB Length = 292 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 137/284 (48%), Gaps = 41/284 (14%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G+ G VC A + +G +VA+K + + + + + E+ +++ +H NV+ + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 92 VFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGII 150 + E + +++M F+ G L ++ +L E++I + +L+ L Y+HA G+I Sbjct: 88 SYLVGE------ELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 151 HRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEVILNWMRYTQTV 207 HRD+K ++ + D +K+ DFG Q ++ V T ++ APEVI + Y V Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEV 200 Query: 208 DIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPE 267 DIWS+G ++ EM+ G+ + + +K ++ +PP + Sbjct: 201 DIWSLGIMVIEMVDGEPPYFSDSPVQAMK---RLRDSPPPKLKNS--------------- 242 Query: 268 LEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 SP+ + LE+MLV D ++R TA E L HP+ Sbjct: 243 ----------HKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >4JDH-A nrPDB Length = 346 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 41/301 (13%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 ++ + R+ + +G G+ G VC A +G VA+KK+ + + + + E Sbjct: 64 QLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNE 121 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFL 133 + +++ +HENV+ + + + + + ++VM F+ G L ++ H ++ E++I + Sbjct: 122 VVIMRDYQHENVVEMYNSYLVGD------ELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 175 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRW 190 +L+ L +HA G+IHRD+K ++ + D +K+ DFG Q E+ V T + Sbjct: 176 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 235 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + APE+I + + Y VDIWS+G ++ EM+ G+ + L +K I Sbjct: 236 WMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---------- 284 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 LP K L SP L+++LV D QR TA E L HP+ Sbjct: 285 -------------NLPPRLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 326 Query: 311 F 311 Sbjct: 327 L 327 >4XBR-A nrPDB Length = 366 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 41/301 (13%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 ++ + R+ + +G G+ G VC A +G VA+KK+ + + + + E Sbjct: 84 QLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNE 141 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFL 133 + +++ +HENV+ + + + + + ++VM F+ G L ++ H ++ E++I + Sbjct: 142 VVIMRDYQHENVVEMYNSYLVGD------ELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 195 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRW 190 +L+ L +HA G+IHRD+K ++ + D +K+ DFG Q E+ V T + Sbjct: 196 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 255 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + APE+I + + Y VDIWS+G ++ EM+ G+ + L +K I Sbjct: 256 WMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---------- 304 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 LP K L SP L+++LV D QR TA E L HP+ Sbjct: 305 -------------NLPPRLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 346 Query: 311 F 311 Sbjct: 347 L 347 >2Q0N-A nrPDB Length = 301 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 141/301 (46%), Gaps = 41/301 (13%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 ++ + R+ + +G G+ G VC A +G VA+KK+ + + + + E Sbjct: 19 QLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNE 76 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFL 133 + +++ +HENV+ + + + + + ++VM F+ G L ++ H ++ E++I + Sbjct: 77 VVIMRDYQHENVVEMYNSYLVGD------ELWVVMEFLEGGALTDIVTHTRMNEEQIAAV 130 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRW 190 +L+ L +HA G+IHRD+K ++ + D +K+ DFG Q E+ V T + Sbjct: 131 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY 190 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + APE+I + + Y VDIWS+G ++ EM+ G+ + L +K I Sbjct: 191 WMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD---------- 239 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 LP K L SP L+++LV D QR TA E L HP+ Sbjct: 240 -------------NLPPRLKN-----LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPF 281 Query: 311 F 311 Sbjct: 282 L 282 >1FOT-A nrPDB Length = 318 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 136/330 (41%), Gaps = 55/330 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRHEN 85 ++ L+ +G+G++G V G A+K L + + E +L + H Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLRY 143 +I + F D +++M ++ G +L L++ ++ +F ++ L Y Sbjct: 68 IIRMWGTF------QDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRY 203 +H+ II+RDLKP N+ ++++ +KI DFG A+ T Y APEV+ + Y Sbjct: 122 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVV-STKPY 180 Query: 204 TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMK 263 +++D WS G ++ EM+ G T F S+ + ++I+ P F Sbjct: 181 NKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFF-------------- 226 Query: 264 GLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYFESLH--- 315 + +LL +++ D QR+ + HP+F+ + Sbjct: 227 -----------------NEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEK 269 Query: 316 ------DTEDEPQVQKYDDSFDDVDRTLDE 339 +T EP +Q+ D+ +E Sbjct: 270 LLSRNIETPYEPPIQQGQGDTSQFDKYPEE 299 >3DAK-A nrPDB Length = 290 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 128/313 (40%), Gaps = 47/313 (15%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 W + R Y + +GSGA V +A KVAIK++ + +E++ + Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKC-QTSMDELLKEIQAM 62 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---------EKLGED 128 H N++ F + + +LVM + G + ++KH L E Sbjct: 63 SQCHHPNIVSYYTSFVVKD------ELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDES 116 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--------DS 180 I ++ ++L+GL Y+H G IHRD+K GN+ + ED ++I DFG++ + Sbjct: 117 TIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNK 176 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 +V T + APEV+ Y DIWS G E+ TG + + L ++ Sbjct: 177 VRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL--MLT 234 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + PP+ + K Y K ++ + L D E+R Sbjct: 235 LQNDPPSLETGVQDKEMLKKYGKSFRKM-------------------ISLCLQKDPEKRP 275 Query: 301 TAGEALAHPYFES 313 TA E L H +F+ Sbjct: 276 TAAELLRHKFFQK 288 >1KOB-A nrPDB Length = 387 Score = 244 bits (622), Expect = 7e-65, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 144/338 (42%), Gaps = 44/338 (13%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 + Q V V Y L+ +GSGA+G V V+ TG K + P+ + + Sbjct: 37 YVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY--T 94 Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGE 127 E+ ++ + H +I L D F +D + L++ F+ G +L + E K+ E Sbjct: 95 VKNEISIMNQLHHPKLINLHDAF------EDKYEMVLILEFLSGGELFDRIAAEDYKMSE 148 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA--VNEDCELKILDFGLARQADSE--MT 183 + + Q +GL+++H I+H D+KP N+ + +KI+DFGLA + + + + Sbjct: 149 AEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVK 208 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 T + APE I++ D+W++G + +++G + F G D L+ L+ + + Sbjct: 209 VTTATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDW 267 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 ++ SP A + ++ +L + +R+T Sbjct: 268 EFDE---------------------------DAFSSVSPEAKDFIKNLLQKEPRKRLTVH 300 Query: 304 EALAHPYFESLH-DTEDEPQVQKYDDSFDDVDRTLDEW 340 +AL HP+ + H + +Y+ + +W Sbjct: 301 DALEHPWLKGDHSNLTSRIPSSRYNKIRQKIKEKYADW 338 >5D9K-A nrPDB Length = 330 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 82/339 (24%), Positives = 138/339 (40%), Gaps = 56/339 (16%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80 + + L+ +G G++G V A+K L + R E +L Sbjct: 29 PSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE 88 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQML 138 + H ++ L F + L YL++ F+ G DL +L K E+ ++F + ++ Sbjct: 89 VNHPFIVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPE 195 L ++H+ GII+RDLKP N+ ++E+ +K+ DFGL++++ + T Y APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 V+ N +TQ+ D WS G +M EM+TG F+G D + + I+K P Sbjct: 203 VV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFL------ 255 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA-----GEALAHPY 310 SP A +LL + + R+ A E H + Sbjct: 256 -------------------------SPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSF 290 Query: 311 F-----ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVT 344 F L+ E P + +D E+ T Sbjct: 291 FSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKT 329 >4JXF-A nrPDB Length = 266 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 125/297 (42%), Gaps = 45/297 (15%) Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ-SELFAKRAYRELRLLK 79 E ++ +G G++ V A TG +VAIK + + +R E+++ Sbjct: 3 GEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHC 62 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKH--EKLGEDRIQFLVYQ 136 ++H +++ L + F +D YLV+ ++ + +K+ + E+ + ++Q Sbjct: 63 QLKHPSILELYNYF------EDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQ 116 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRA 193 ++ G+ Y+H+ GI+HRDL NL + + +KI DFGLA Q + T Y + Sbjct: 117 IITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYIS 176 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 PE I + D+WS+GC+ ++ G+ F + L +++ P+ Sbjct: 177 PE-IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFL---- 231 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 S A +L+ ++L + R++ L HP+ Sbjct: 232 ---------------------------SIEAKDLIHQLLRRNPADRLSLSSVLDHPF 261 >4QMW-A nrPDB Length = 310 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 76/310 (24%), Positives = 125/310 (40%), Gaps = 44/310 (14%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P +SG + K E ++ L+ +G G++G V +D RT VAIK + + Sbjct: 12 PVQSGLPGMQNLKADPE--ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED 69 Query: 66 LFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEK 124 +E+ +L V + D T +++M ++G L++ Sbjct: 70 EIED-IQQEITVLSQCDSPYVTKYYGSYLKD------TKLWIIMEYLGGGSALDLLEPGP 122 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--- 181 L E +I ++ ++LKGL Y+H+ IHRD+K N+ ++E E+K+ DFG+A Q Sbjct: 123 LDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK 182 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 +V T ++ APEVI Y DIWS+G E+ G+ + L I Sbjct: 183 RNTFVGTPFWMAPEVI-KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI--- 238 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 K + ++ N S +E L + R T Sbjct: 239 ---------------------------PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPT 271 Query: 302 AGEALAHPYF 311 A E L H + Sbjct: 272 AKELLKHKFI 281 >6FYV-A nrPDB Length = 337 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 84/329 (25%), Positives = 145/329 (44%), Gaps = 42/329 (12%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGR-TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 +RA Y + +G GA+G V +D G VA+K + + + A E+++L+H+ Sbjct: 12 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG---RYREAARSEIQVLEHL 68 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE---KLGEDRIQFLVYQML 138 + + E D +V +G +K D I+ + YQ+ Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNE-------------------DCELKILDFGLARQAD 179 + + ++H + H DLKP N+ + + ++K++DFG A D Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 188 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 + V TR YRAPEVIL + ++Q D+WS+GCI+ E G T+F+ D + L + Sbjct: 189 EHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 247 Query: 240 KVTGTPPAEFVQRLQSDE--------------AKNYMKGLPELEKKDFASILTNASPLAV 285 ++ G P +Q+ + + A Y++ + K+F Sbjct: 248 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDEEHEKLF 306 Query: 286 NLLEKMLVLDAEQRVTAGEALAHPYFESL 314 +L+ +ML D QR+T EAL HP+F+ L Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFDLL 335 >2Z7Q-A nrPDB Length = 321 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 137/327 (41%), Gaps = 56/327 (17%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80 + + L+ +G G++G V +G A+K L + R E +L Sbjct: 27 PSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD 86 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQML 138 + H V+ L F + L YL++ F+ G DL +L K E+ ++F + ++ Sbjct: 87 VNHPFVVKLHYAFQTEGKL------YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPE 195 GL ++H+ GII+RDLKP N+ ++E+ +K+ DFGL+++A + T Y APE Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPE 200 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 V+ N ++ + D WS G +M EM+TG F+G D + + I+K P Sbjct: 201 VV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFL------ 253 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPY 310 S A +LL + + R+ A E H + Sbjct: 254 -------------------------STEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVF 288 Query: 311 F-----ESLHDTEDEPQVQKYDDSFDD 332 + L+ E +P + DD Sbjct: 289 YSTIDWNKLYRREIKPPFKPAVAQPDD 315 >3TXO-A nrPDB Length = 353 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 132/334 (39%), Gaps = 56/334 (16%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMR- 82 + ++ +G G++G V A TG A+K L + + + E R+L R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFLVYQMLKG 140 H + L F + L + VM F+ G DL + K + E R +F +++ Sbjct: 83 HPFLTQLFCCFQTPDRL------FFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISA 136 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVI 197 L ++H GII+RDLK N+ ++ + K+ DFG+ ++ + T Y APE I Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPE-I 195 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L M Y VD W++G ++ EM+ G F+ + D + I+ P Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWL-------- 247 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-TAGE-----ALAHPYF 311 A +L+ + + R+ + + L HP+F Sbjct: 248 -----------------------HEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF 284 Query: 312 E-----SLHDTEDEPQVQKYDDSFDDVDRTLDEW 340 + L+ + EP + S +DV ++ Sbjct: 285 KEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDF 318 >2UV2-A nrPDB Length = 325 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 78/356 (21%), Positives = 139/356 (39%), Gaps = 54/356 (15%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAV-----YRDLQPVGSGAYGAVCSAVDGRTGAKVAIK 56 S Y Q + + R + + + +G GA+G V A + T A K Sbjct: 9 SGVDLGTENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAK 68 Query: 57 KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-- 114 + + EL + E+ +L H N++ LLD F + + ++++ F Sbjct: 69 VIDTKSEEEL--EDYMVEIDILASCDHPNIVKLLDAFYYE------NNLWILIEFCAGGA 120 Query: 115 -DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 D L L E +IQ + Q L L Y+H IIHRDLK GN+ D ++K+ DFG Sbjct: 121 VDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFG 180 Query: 174 LARQAD---SEMTGYVVTRWYRAPEVIL----NWMRYTQTVDIWSVGCIMAEMITGKTLF 226 ++ + ++ T ++ APEV++ Y D+WS+G + EM + Sbjct: 181 VSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPH 240 Query: 227 KGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN 286 + + L +I K + P Q + S + Sbjct: 241 HELNPMRVLLKIAK---SEPPTLAQPSRW-------------------------SSNFKD 272 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKR 342 L+K L + + R T + L HP+ ++P + ++ +V +++ K Sbjct: 273 FLKKCLEKNVDARWTTSQLLQHPFVTV---DSNKPIRELIAEAKAEVTEEVEDGKE 325 >4B6L-A nrPDB Length = 281 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 124/302 (41%), Gaps = 44/302 (14%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHE 84 Y + +G G + A D TG+ A+K + ++ E+ L + ++H Sbjct: 10 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 69 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMK-HEKLGEDRIQFLVYQMLKGLR 142 +++ +D + Y+ + L + K L E +++ + Q+L GL+ Sbjct: 70 HIVRF------SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLK 123 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILN 199 Y+H GI+HRDLK GN + E+ ELK+ DFGLA + + T Y APEV+L Sbjct: 124 YLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL- 182 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + D+WS+GC+M ++ G F+ +D + + I +V T PA Sbjct: 183 RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL---------- 232 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTED 319 S A LL +L R + + L H +F + + Sbjct: 233 ---------------------SLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDR 271 Query: 320 EP 321 P Sbjct: 272 LP 273 >2X4F-A nrPDB Length = 373 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 84/319 (26%), Positives = 140/319 (43%), Gaps = 45/319 (14%) Query: 5 PPARSGFYRQEVTKTAWEVRAVYRDLQP--VGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 P + F + VT V + Y + +G G +G V + TG K+A K + Sbjct: 67 PAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRG 126 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM 120 + + E+ ++ + H N+I L D F + D LVM ++ G +++ Sbjct: 127 MKDK--EEVKNEISVMNQLDHANLIQLYDAF------ESKNDIVLVMEYVDGGELFDRII 178 Query: 121 KHEK-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA-VNEDC-ELKILDFGLARQ 177 L E + Q+ +G+R++H I+H DLKP N+ VN D ++KI+DFGLAR+ Sbjct: 179 DESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARR 238 Query: 178 ADSEMTGYV--VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 V T + APEV+ N+ + D+WSVG I +++G + F G + + L Sbjct: 239 YKPREKLKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETL 297 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 I+ +LE ++F I S A + K+L+ + Sbjct: 298 NNILACRW-----------------------DLEDEEFQDI----SEEAKEFISKLLIKE 330 Query: 296 AEQRVTAGEALAHPYFESL 314 R++A EAL HP+ Sbjct: 331 KSWRISASEALKHPWLSDH 349 >6FDY-U nrPDB Length = 276 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 128/299 (42%), Gaps = 42/299 (14%) Query: 27 YRDLQPVGSGAYGAVCSAV-DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 + + +GSG Y V A T VAIK + + ++ + E+ +LK +RH + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPH 72 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK-LGEDRIQFLVYQMLKGLRY 143 ++ L D D + YL+M F G DL + + + L E + + Q+ L++ Sbjct: 73 IVQLKDF------QWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 144 IHAAGIIHRDLKPGNLAVN--EDCELKILDFGLARQADSEMTGYV--VTRWYRAPEVILN 199 +H I H DLKP N+ ++ E LK+ DFG A+ +V + Y APE++ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQ 186 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y VD+WS+G I+ E + G+ F + ++I Sbjct: 187 RQ-YDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIR-------------------S 226 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 N + LP + S +LL+++L D +R++ + AHP+ + H Sbjct: 227 NRVIELP---------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >5X8I-B nrPDB Length = 346 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 87/333 (26%), Positives = 147/333 (44%), Gaps = 44/333 (13%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTG-AKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + A Y + +G GA+G V +D + G VA+K + + + + A E+++L+H+ Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHL 67 Query: 82 R--HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE---KLGEDRIQFLVYQ 136 N E + +V +G +K D I+ + YQ Sbjct: 68 NTTDPN--STFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQ 125 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNE-------------------DCELKILDFGLARQ 177 + K + ++H+ + H DLKP N+ + + ++K++DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 185 Query: 178 ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 D + V TR YRAPEVIL + ++Q D+WS+GCI+ E G T+F D + L Sbjct: 186 DDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAM 244 Query: 238 IMKVTGTPPAEFVQ-----------RLQSDEAKNYMKGLPELEK--KDFASILTNASPLA 284 + ++ G P +Q RL DE + + + K K+F Sbjct: 245 MERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERL 304 Query: 285 VNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 +L++KML D +R+T EAL HP+F+ L + Sbjct: 305 FDLIQKMLEYDPAKRITLREALKHPFFDLLKKS 337 >3HDN-A nrPDB Length = 373 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 135/342 (39%), Gaps = 54/342 (15%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYREL 75 + + + L+ +G G++G V A A+K L + + K E Sbjct: 30 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 89 Query: 76 RLL-KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQF 132 +L K+++H ++GL F + L Y V+ ++ G L + E R +F Sbjct: 90 NVLLKNVKHPFLVGLHFSFQTADKL------YFVLDYINGGELFYHLQRERCFLEPRARF 143 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTR 189 ++ L Y+H+ I++RDLKP N+ ++ + + DFGL ++ +S + + T Sbjct: 144 YAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTP 203 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 Y APEV+ + Y +TVD W +G ++ EM+ G F + + I+ Sbjct: 204 EYLAPEVL-HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP------- 255 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG----EA 305 + N + A +LLE +L D +R+ A E Sbjct: 256 ------------------------LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEI 291 Query: 306 LAHPYF-----ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKR 342 +H +F + L + + P +D+ E+ Sbjct: 292 KSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTE 333 >4U41-A nrPDB Length = 332 Score = 237 bits (604), Expect = 6e-63, Method: Composition-based stats. Identities = 87/335 (25%), Positives = 134/335 (40%), Gaps = 47/335 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RH 83 ++ ++ VG+G YG V +TG AIK + E K E+ +LK H Sbjct: 24 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHH 80 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMG----TDLGKLMKHEKLGEDRIQFLVYQMLK 139 N+ F +LVM F G TDL K K L ED I ++ ++L+ Sbjct: 81 RNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILR 140 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEMTGYVVTRWYRAPEV 196 GL ++H +IHRD+K N+ + E+ E+K++DFG++ Q D ++ T ++ APEV Sbjct: 141 GLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 200 Query: 197 ILNWMR----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 I Y D+WS G EM G + L I + PP + Sbjct: 201 IACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR---NPPPRLKSK 257 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 S + ++++G LV + QR + + L HP+ Sbjct: 258 KWSKKFFSFIEG--------------------------CLVKNYMQRPSTEQLLKHPFI- 290 Query: 313 SLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKE 347 D +E QV+ D R K T E Sbjct: 291 --RDQPNERQVRIQLKDHIDRTRKKRGEKDETEYE 323 >3HKO-A nrPDB Length = 345 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 89/366 (24%), Positives = 139/366 (37%), Gaps = 90/366 (24%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 R Y Q + E++ Y +G G+YG V A++ +T A AIK + + + Sbjct: 9 SGRENLYFQG--GSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQ 66 Query: 66 LFAKRAYR---ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL- 119 + K R E+RL+K + H N+ L +V+ +D LVM G L KL Sbjct: 67 INPKDVERIKTEVRLMKKLHHPNIARLYEVY------EDEQYICLVMELCHGGHLLDKLN 120 Query: 120 ------------------------MKHEKLG---------------EDRIQFLVYQMLKG 140 E + E I ++ Q+ Sbjct: 121 VFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSA 180 Query: 141 LRYIHAAGIIHRDLKPGNLAV--NEDCELKILDFGLARQADS-------EMTGYVVTRWY 191 L Y+H GI HRD+KP N N+ E+K++DFGL+++ MT T ++ Sbjct: 181 LHYLHNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYF 240 Query: 192 RAPEVI-LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 APEV+ Y D WS G ++ ++ G F G + D + +++ Sbjct: 241 VAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCF----- 295 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 E NY SPLA +LL +L + ++R A AL HP+ Sbjct: 296 ------ENPNY----------------NVLSPLARDLLSNLLNRNVDERFDAMRALQHPW 333 Query: 311 FESLHD 316 D Sbjct: 334 ISQFSD 339 >5DBX-A nrPDB Length = 328 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 128/318 (40%), Gaps = 47/318 (14%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 W + R Y + +GSGA V +A+ +VAIK++ + +E++ + Sbjct: 5 GWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKC-QTSMDELLKEIQAM 63 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---------EKLGED 128 H NV+ F + + +LVM + G + ++K+ L E Sbjct: 64 SQCSHPNVVTYYTSFVVKD------ELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEA 117 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--------DS 180 I ++ ++L+GL Y+H G IHRDLK GN+ + ED ++I DFG++ + Sbjct: 118 IIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNK 177 Query: 181 EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 +V T + APEV+ Y D+WS G E+ TG + + L ++ Sbjct: 178 VRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL--MLT 235 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + PP + K Y K + LL L D +R Sbjct: 236 LQNDPPTLETGVEDKEMMKKYGKSFRK-------------------LLSLCLQKDPSKRP 276 Query: 301 TAGEALAHPYFESLHDTE 318 TA E L +F+ + E Sbjct: 277 TAAELLKCKFFQKAKNRE 294 >2XIK-A nrPDB Length = 294 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 118/320 (36%), Gaps = 45/320 (14%) Query: 4 PPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ 63 GF Q E+ + L +G G++G V +D T VAIK + Sbjct: 1 SMAHLRGFANQHSRVDPEEL---FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEA 57 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKH 122 + +E+ +L + + T +++M ++G L+K Sbjct: 58 EDEIED-IQQEITVLSQCDSPYITRYFGSYLKS------TKLWIIMEYLGGGSALDLLKP 110 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE- 181 L E I ++ ++LKGL Y+H+ IHRD+K N+ ++E ++K+ DFG+A Q Sbjct: 111 GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ 170 Query: 182 --MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 +V T ++ APEVI Y DIWS+G E+ G+ + L I Sbjct: 171 IKRNTFVGTPFWMAPEVI-KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIP 229 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 K +PP Q S +E L D R Sbjct: 230 K--NSPPTLEGQH----------------------------SKPFKEFVEACLNKDPRFR 259 Query: 300 VTAGEALAHPYFESLHDTED 319 TA E L H + Sbjct: 260 PTAKELLKHKFITRYTKKTS 279 >4YNZ-A nrPDB Length = 342 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 125/302 (41%), Gaps = 44/302 (14%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 YR + +G G G V + T KVAIK + R SE + RE+ +LK + H +V Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 + L DV+ ++ YLV+ + G L+K +L + Q++ L + Sbjct: 72 LKLHDVY------ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 125 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWMR 202 H+ I HRDLKP NL ++E ++I DFG+A DS + + Y PEVI Sbjct: 126 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 + D+WS G I+ ++ G F + L+++ + P Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP---------------- 229 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQ 322 P +LL M+ +DA +R+T H + ++EP+ Sbjct: 230 ---------------HFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIW---YIGGKNEPE 271 Query: 323 VQ 324 + Sbjct: 272 PE 273 >6CMJ-A nrPDB Length = 321 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 128/315 (40%), Gaps = 48/315 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP---------FQSELFAKRAYREL 75 Y +G G+YG V A + A+K L + Q ++ Y+E+ Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLV 134 +LK + H NV+ L++V + Y+V + + ++ + L ED+ +F Sbjct: 94 AILKKLDHPNVVKLVEVLDDP----NEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYF 149 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSEMTGYVVTRWY 191 ++KG+ Y+H IIHRD+KP NL V ED +KI DFG++ + +D+ ++ V T + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 192 RAPEVILNWMRY--TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 APE + + + +D+W++G + + G+ F + +I P + Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQ- 268 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 + + +L+ +ML + E R+ E HP Sbjct: 269 ----------------------------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHP 300 Query: 310 YFESLHDTEDEPQVQ 324 + + + Sbjct: 301 WVTRHGAEPLPSEDE 315 >4FZF-B nrPDB Length = 283 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 117/294 (39%), Gaps = 42/294 (14%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + ++ L+ +G G++G V +D RT VAIK + + +E+ +L Sbjct: 5 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIED-IQQEITVLSQC 63 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG-KLMKHEKLGEDRIQFLVYQMLKG 140 V + L +++M ++G L++ E +I ++ ++LKG Sbjct: 64 DSSYVTKYYGSYLKGSKL------WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKG 117 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVI 197 L Y+H+ IHRD+K N+ ++E ++K+ FG+A Q +V T ++ APEVI Sbjct: 118 LDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI 177 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 Y DIWS+G E+ G+ + L I Sbjct: 178 -QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI------------------- 217 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 K + +++ + + ++ L D R TA E L H + Sbjct: 218 -----------PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >5X3F-B nrPDB Length = 393 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 121/295 (41%), Gaps = 46/295 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRH 83 + ++ +G+G++G V +G A+K L + + + E R+L+ + Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 143 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++ L + + D ++ Y+VM ++ G L + + E +F Q++ Sbjct: 144 PFLVKL------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 197 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201 Y+H+ +I+RDLKP NL +++ +++ DFG A++ T Y APE+IL+ Sbjct: 198 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-K 256 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 Y + VD W++G ++ EM G F + ++I+ P+ F Sbjct: 257 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF------------ 304 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYF 311 S +LL +L +D +R + H +F Sbjct: 305 -------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >6O6Q-A nrPDB Length = 335 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 86/327 (26%), Positives = 168/327 (51%), Gaps = 27/327 (8%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 +S+ P ++ + W + Y L+ +G G Y V +D KV IK L Sbjct: 20 LSTKPQ---SYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK- 75 Query: 61 PFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGK 118 + K+ RE+ +LK++ N+I +LDV ++ L+ + D Sbjct: 76 ----PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPG----LIFEHINNIDFRS 127 Query: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLAR- 176 L + + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ D + L+++D+GLA Sbjct: 128 L--YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEY 185 Query: 177 -QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL-FKGSDHLDQ 234 +E V +R+++ PE+++++ Y ++D+WS GC++A M+ K F G + DQ Sbjct: 186 YHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQ 245 Query: 235 LKEIMKVTGTPP-AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLL 288 L +I++V G+ +++++ + Y + + K+ + + S ++L+ Sbjct: 246 LVQIVRVLGSKNFKKYLEKYNISLGEEY-EDIGYYNKRQWVRFMNENNKDLVSQEFLDLI 304 Query: 289 EKMLVLDAEQRVTAGEALAHPYFESLH 315 +++L D ++R+TA EA+ H YF+ + Sbjct: 305 DRLLRYDHQERLTAKEAMKHAYFDPIR 331 >5J5T-A nrPDB Length = 370 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 135/328 (41%), Gaps = 50/328 (15%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + + +Q +GSG YG V A + TG AIK + + +E+ ++K +H Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKH 60 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGL 141 N++ + + L ++ M F G + + H L E +I ++ + L+GL Sbjct: 61 PNIVAYFGSYLRRDKL------WICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGL 114 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRWYRAPEV-- 196 Y+H+ G +HRD+K N+ + ++ +K+ DFG++ Q + + ++ T ++ APEV Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAA 174 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + Y Q D+W+VG E+ + + L + K PP Sbjct: 175 VERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL-------- 226 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES--- 313 +K +++ + ++ L + ++R TA + L HP+ Sbjct: 227 -----------KDKMKWSNSFHH-------FVKMALTKNPKKRPTAEKLLQHPFVTQHLT 268 Query: 314 ------LHDTEDEPQVQKYDDSFDDVDR 335 L D + P Y D DD Sbjct: 269 RSLAIELLDKVNNPDHSTYHDFDDDDPE 296 >3ORZ-A nrPDB Length = 316 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 84/313 (26%), Positives = 133/313 (42%), Gaps = 48/313 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRH 83 ++ + +G G++ V A + T + AIK L R E RE ++ + H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 + L F DE L F L G L + K E +F +++ L Y Sbjct: 97 PFFVKLYFCFQDDEKL----YFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEY 152 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT-----GYVVTRWYRAPEVIL 198 +H GIIHRDLKP N+ +NED ++I DFG A+ E +V T Y +PE +L Sbjct: 153 LHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE-LL 211 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 ++ D+W++GCI+ +++ G F+ + ++I+K+ P +F Sbjct: 212 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFF-------- 263 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE------ALAHPYFE 312 P A +L+EK+LVLDA +R+ E AHP+FE Sbjct: 264 -----------------------PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFE 300 Query: 313 SLHDTEDEPQVQK 325 S+ Q Sbjct: 301 SVTWENLHQQTPP 313 >3DB8-A nrPDB Length = 317 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 75/322 (23%), Positives = 128/322 (39%), Gaps = 44/322 (13%) Query: 6 PARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE 65 P + Y + +G G + D T A K + + + Sbjct: 23 PKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLK 82 Query: 66 LFAKRAYR-ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG--TDLGKLMKH 122 K E+ + K + + +V+G F +D Y+V+ + L + Sbjct: 83 PHQKEKMSTEIAIHKSLDNPHVVGFHGFF------EDDDFVYVVLEICRRRSLLELHKRR 136 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---D 179 + + E ++ + Q ++G++Y+H +IHRDLK GNL +N+D ++KI DFGLA + Sbjct: 137 KAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDG 196 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 T Y APEV+ ++ VDIWS+GCI+ ++ GK F+ S + I Sbjct: 197 ERKKDLCGTPNYIAPEVLCK-KGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI- 254 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 KK+ S+ + +P+A L+ +ML D R Sbjct: 255 ------------------------------KKNEYSVPRHINPVASALIRRMLHADPTLR 284 Query: 300 VTAGEALAHPYFESLHDTEDEP 321 + E L +F S + P Sbjct: 285 PSVAELLTDEFFTSGYAPMRLP 306 >3KN6-A nrPDB Length = 325 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 132/304 (43%), Gaps = 41/304 (13%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGL 89 +P+G G++ V ++ A+K + + ++ +E+ LK H N++ L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEA-----NTQKEITALKLCEGHPNIVKL 71 Query: 90 LDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAA 147 +VF D +LVM + G ++ K + E +++ +++ + ++H Sbjct: 72 HEVF------HDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 125 Query: 148 GIIHRDLKPGNLAV---NEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILNWM 201 G++HRDLKP NL N++ E+KI+DFG AR + + T Y APE +LN Sbjct: 126 GVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQN 184 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 Y ++ D+WS+G I+ M++G+ F+ D + L A Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHD--------------------RSLTCTSAVEI 224 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEP 321 MK + + + N S A +L++ +L +D +R+ + + + P Sbjct: 225 MKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNP 284 Query: 322 QVQK 325 + Sbjct: 285 LMTP 288 >4WB7-A nrPDB Length = 405 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 121/295 (41%), Gaps = 46/295 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRH 83 + ++ +G+G++G V TG A+K L + + + E R+L+ + Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++ L + + D ++ Y+VM ++ G L + + E +F Q++ Sbjct: 156 PFLVKL------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 209 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201 Y+H+ +I+RDLKP NL +++ +++ DFG A++ T Y APE+IL+ Sbjct: 210 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILS-K 268 Query: 202 RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 Y + VD W++G ++ EM G F + ++I+ P+ F Sbjct: 269 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF------------ 316 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYF 311 S +LL +L +D +R + H +F Sbjct: 317 -------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >3NYO-A nrPDB Length = 576 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 89/332 (26%), Positives = 142/332 (42%), Gaps = 57/332 (17%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 RQ VTK +R + +G G +G VC+ TG A KKL + + + Sbjct: 176 LERQPVTKNT------FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEA 229 Query: 71 -AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK---L 125 A E ++L+ + V+ L + + L LV+ M G DL + H Sbjct: 230 MALNEKQILEKVNSRFVVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGF 283 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT-- 183 E R F ++ GL +H I++RDLKP N+ +++ ++I D GLA T Sbjct: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK 343 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 G V T Y APEV+ N RYT + D W++GC++ EMI G++ F+ + +E+ ++ Sbjct: 344 GRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK 402 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV--- 300 P E+ +R SP A +L ++L D +R+ Sbjct: 403 EVPEEYSERF---------------------------SPQARSLCSQLLCKDPAERLGCR 435 Query: 301 --TAGEALAHPYFESLH-----DTEDEPQVQK 325 +A E HP F+ L+ EP + Sbjct: 436 GGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 >4CSV-A nrPDB Length = 275 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 123/299 (41%), Gaps = 50/299 (16%) Query: 19 TAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 WE+ R+ + +GSG +G V +VA+K L + + + +E ++ Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLK---EGTMSVEEFLQEAQI 60 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL--MKHEKLGEDRIQFL 133 +K ++H N++ L V T + + Y++ +M G+ L L + + + + Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPI------YIITEYMSHGSLLDYLRDCEGHTVNAQALLDM 114 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS-EMTGYVVTRW-- 190 Q+ G+ Y+ + IHRDL N V E+ +K+ DFGLAR + E T ++ Sbjct: 115 AAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPI 174 Query: 191 -YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAE 248 + APE I ++ R++ D+W+ G ++ E+ T G+ + G + ++++ + P + Sbjct: 175 KWTAPEAI-SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQ 233 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 L+ + E+R T E L Sbjct: 234 ------------------------------GCPEEIYELMLQCWNKSPEERPTFAETLH 262 >1U5R-A nrPDB Length = 348 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 81/333 (24%), Positives = 140/333 (42%), Gaps = 43/333 (12%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKH 80 + ++ DL+ +G G++GAV A D R VAIKK+ Y QS + +E+R L+ Sbjct: 51 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 110 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM--KHEKLGEDRIQFLVYQML 138 +RH N I + + T +LVM + L+ + L E I + + L Sbjct: 111 LRHPNTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGAL 164 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVIL 198 +GL Y+H+ +IHRD+K GN+ ++E +K+ DFG A + +V T ++ APEVIL Sbjct: 165 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM-APANSFVGTPYWMAPEVIL 223 Query: 199 --NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + +Y VD+WS+G E+ K + + L I + Sbjct: 224 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 267 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 P L+ + S N ++ L + R T+ L H + Sbjct: 268 ------NESPALQSGHW-------SEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP 314 Query: 317 TE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKE 347 + + D + + + K++ ++E Sbjct: 315 PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 347 >3LM0-A nrPDB Length = 327 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 79/356 (22%), Positives = 147/356 (41%), Gaps = 57/356 (16%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDL--QPVGSGAYGAVCSAVDGRTGAKVAIKKLY 59 S Y Q + + L + +G G + V + TG + A K L Sbjct: 9 SGVDLGTENLYFQSMENFN-----NFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLK 63 Query: 60 RPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG 117 + + + E+ +L+ + VI L +V+ ++ ++ L++ + G ++ Sbjct: 64 KRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVY------ENTSEIILILEYAAGGEIF 117 Query: 118 KLMK---HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCELKILD 171 L E + E+ + L+ Q+L+G+ Y+H I+H DLKP N+ ++ ++KI+D Sbjct: 118 SLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVD 177 Query: 172 FGLARQADS--EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 FG++R+ E+ + T Y APE ILN+ T D+W++G I ++T + F G Sbjct: 178 FGMSRKIGHACELREIMGTPEYLAPE-ILNYDPITTATDMWNIGIIAYMLLTHTSPFVGE 236 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 D+ + I +V E ++ S LA + ++ Sbjct: 237 DNQETYLNISQVNVDYSEE---------------------------TFSSVSQLATDFIQ 269 Query: 290 KMLVLDAEQRVTAGEALAHPYFESL------HDTEDEPQVQKYDDSFDDVDRTLDE 339 +LV + E+R TA L+H + + H E Q D S + + Sbjct: 270 SLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSK 325 >2WO6-A nrPDB Length = 382 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 88/345 (25%), Positives = 148/345 (42%), Gaps = 50/345 (14%) Query: 16 VTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 + K + Y +G G++G V A D VAIK + + F +A E+ Sbjct: 45 IVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK---NKKAFLNQAQIEV 101 Query: 76 RLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL---GEDRIQ 131 RLL+ M H+ + + LV + +L L+++ + + Sbjct: 102 RLLELMNKHDTEMKYY-IVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTR 160 Query: 132 FLVYQMLKGLRYIH--AAGIIHRDLKPGNLAV--NEDCELKILDFGLARQADSEMTGYVV 187 QM L ++ IIH DLKP N+ + + +KI+DFG + Q + Y+ Sbjct: 161 KFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQ 220 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 +R+YR+PEV+L M Y +D+WS+GCI+ EM TG+ LF G++ +DQ+ +I++V G PPA Sbjct: 221 SRFYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 279 Query: 248 EFVQRLQSDEAKNYMKGLPE--LEKKDFASILTNASP----------------------- 282 + Q+ +A+ + + LP+ K P Sbjct: 280 HILD--QAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAG 337 Query: 283 ----------LAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDT 317 +L+ +ML D + R+ AL H +F+ D Sbjct: 338 ESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >2OU7-A nrPDB Length = 335 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 127/295 (43%), Gaps = 44/295 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ-SELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G + D T A K + + ++ E+ + + + H++V+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 92 VFTPDETLDDFTDFYLVMPFMG--TDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 F +D ++V+ + L + + L E ++ + Q++ G +Y+H + Sbjct: 109 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNWMRYTQT 206 IHRDLK GNL +NED E+KI DFGLA + T Y APEV+ + ++ Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFE 221 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VD+WS+GCIM ++ GK F+ S + I Sbjct: 222 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRI---------------------------- 253 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEP 321 KK+ SI + +P+A +L++KML D R T E L +F S + P Sbjct: 254 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 305 >4I6B-A nrPDB Length = 308 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 127/300 (42%), Gaps = 44/300 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRH 83 Y + +G G + D A K + S+ ++ +E+ L + + H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHEK-LGEDRIQFLVYQMLKGL 141 ++V+ F +D + Y+++ + + ++K K L E +++ + Q++ GL Sbjct: 88 KHVVQFYHYF------EDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGL 141 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS---EMTGYVVTRWYRAPEVIL 198 +Y+H I+HRDLK GN +NE ELK+ DFGLA + + T Y +PEV+ Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL- 200 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 N + DIW++GC+M M+ G+ F+ ++ + + I + T P+ + Sbjct: 201 NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLL-------- 252 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 A +L+ ML + E R + + + H +F + Sbjct: 253 -----------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPD 289 >5YV8-A nrPDB Length = 298 Score = 230 bits (586), Expect = 8e-61, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 126/316 (39%), Gaps = 63/316 (19%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP------------------------F 62 Y +G G+YG V A + A+K L + Sbjct: 15 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 74 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMK 121 Q ++ Y+E+ +LK + H NV+ L++V + Y+V + + ++ Sbjct: 75 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDP----NEDHLYMVFELVNQGPVMEVPT 130 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQA 178 + L ED+ +F ++KG+ Y+H IIHRD+KP NL V ED +KI DFG++ + + Sbjct: 131 LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGS 190 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRY--TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 D+ ++ V T + APE + + + +D+W++G + + G+ F + Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHS 250 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 +I P + + + +L+ +ML + Sbjct: 251 KIKSQALEFPDQ-----------------------------PDIAEDLKDLITRMLDKNP 281 Query: 297 EQRVTAGEALAHPYFE 312 E R+ E HP+ Sbjct: 282 ESRIVVPEIKLHPWVT 297 >2GCD-A nrPDB Length = 309 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 81/333 (24%), Positives = 140/333 (42%), Gaps = 43/333 (12%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKH 80 + ++ DL+ +G G++GAV A D R VAIKK+ Y QS + +E+R L+ Sbjct: 12 DPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQK 71 Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM--KHEKLGEDRIQFLVYQML 138 +RH N I + + T +LVM + L+ + L E I + + L Sbjct: 72 LRHPNTIQYRGCYLREHTA------WLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGAL 125 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVIL 198 +GL Y+H+ +IHRD+K GN+ ++E +K+ DFG A + +V T ++ APEVIL Sbjct: 126 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIM-APANSFVGTPYWMAPEVIL 184 Query: 199 --NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + +Y VD+WS+G E+ K + + L I + Sbjct: 185 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ---------------- 228 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 P L+ + S N ++ L + R T+ L H + Sbjct: 229 ------NESPALQSGHW-------SEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERP 275 Query: 317 TE--DEPQVQKYDDSFDDVDRTLDEWKRVTYKE 347 + + D + + + K++ ++E Sbjct: 276 PTVIMDLIQRTKDAVRELDNLQYRKMKKILFQE 308 >4J52-A nrPDB Length = 293 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 127/295 (43%), Gaps = 44/295 (14%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ-SELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G + D T A K + + ++ E+ + + + H++V+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 92 VFTPDETLDDFTDFYLVMPFMG--TDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 F +D ++V+ + L + + L E ++ + Q++ G +Y+H + Sbjct: 82 FF------EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 150 IHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILNWMRYTQT 206 IHRDLK GNL +NED E+KI DFGLA + T Y APEV+ + ++ Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFE 194 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 VD+WS+GCIM ++ GK F+ S + I Sbjct: 195 VDVWSIGCIMYTLLVGKPPFETSCLKETYLRI---------------------------- 226 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEP 321 KK+ SI + +P+A +L++KML D R T E L +F S + P Sbjct: 227 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLP 278 >1VZO-A nrPDB Length = 355 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 139/309 (44%), Gaps = 51/309 (16%) Query: 25 AVYRDLQPVGSGAYGAVCSAVD---GRTGAKVAIKKLYRP--FQSELFAKRAYRELRLLK 79 + L+ +G+GAYG V TG A+K L + Q + E ++L+ Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 80 HMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQ 136 H+R ++ L F + T +L++ ++ G L + E+ E +Q V + Sbjct: 114 HIRQSPFLVTLHYAFQTE------TKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE 167 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT----GYVVTRWYR 192 ++ L ++H GII+RD+K N+ ++ + + + DFGL+++ ++ T + T Y Sbjct: 168 IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYM 227 Query: 193 APEVILNW-MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 AP+++ + + VD WS+G +M E++TG + F + EI Sbjct: 228 APDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI------------- 274 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEAL 306 ++ +K P + S LA +L++++L+ D ++R+ A E Sbjct: 275 ------SRRILKSEPPYPQ--------EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIK 320 Query: 307 AHPYFESLH 315 H +F+ ++ Sbjct: 321 EHLFFQKIN 329 >5F9E-A nrPDB Length = 353 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 80/350 (22%), Positives = 144/350 (41%), Gaps = 55/350 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAKRAYRELRLLKH-MR 82 + + +G G++G V A +T AIK L + + + E R+L Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFLVYQMLKG 140 H + + F E + + VM ++ G DL + K R F +++ G Sbjct: 79 HPFLTHMFCTFQTKE------NLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILG 132 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVI 197 L+++H+ GI++RDLK N+ +++D +KI DFG+ ++ D++ + T Y APE++ Sbjct: 133 LQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 L +Y +VD WS G ++ EM+ G++ F G D + I P + Sbjct: 193 LG-QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEK------ 245 Query: 258 AKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA-GEALAHPYFESLH- 315 A +LL K+ V + E+R+ G+ HP F ++ Sbjct: 246 -------------------------EAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINW 280 Query: 316 --------DTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQL 357 D P+V+ D + L+E R+++ + Q Sbjct: 281 EELERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQN 330 >5N23-A nrPDB Length = 352 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 119/296 (40%), Gaps = 47/296 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRH 83 + ++ +G+G++G V TG A+K L + + + E R+ + + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ++ L + + D ++ Y+V+ + G L + + E +F Q++ Sbjct: 102 PFLVKL------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTF 155 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT-GYVVTRWYRAPEVILNW 200 Y+H+ +I+RDLKP NL +++ +K+ DFG A++ T Y APE+IL+ Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILS- 214 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y + VD W++G ++ EM G F + ++I+ P+ F Sbjct: 215 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF----------- 263 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYF 311 S +LL +L +D +R + H +F Sbjct: 264 --------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >4B8L-A nrPDB Length = 286 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 125/311 (40%), Gaps = 43/311 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRH 83 + +P+G G +G V A + + +A+K L++ + E + RE+ + H+RH Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 N++ + + F D YL++ F G +L KH + E R + ++ L Sbjct: 75 PNILRMYNYF------HDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADAL 128 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS-EMTGYVVTRWYRAPEVILNW 200 Y H +IHRD+KP NL + ELKI DFG + A S T Y PE+I Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEG- 187 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 + + VD+W G + E + G F H + + I+ V P Sbjct: 188 KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFL----------- 236 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 S + +L+ K+L QR+ + HP+ ++ + Sbjct: 237 --------------------SDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKA-NSRRVL 275 Query: 321 PQVQKYDDSFD 331 P V + S D Sbjct: 276 PGVYQSTQSKD 286 >6HXF-B nrPDB Length = 302 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 129/307 (42%), Gaps = 46/307 (14%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + V+ + +G GA+G V A + TGA A K + + EL + E+ +L Sbjct: 16 DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEEL--EDYIVEIEILATC 73 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT---DLGKLMKHEKLGEDRIQFLVYQML 138 H ++ LL + D L ++++ F D L L E +IQ + QML Sbjct: 74 DHPYIVKLLGAYYHDGKL------WIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQML 127 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPE 195 + L ++H+ IIHRDLK GN+ + + ++++ DFG++ + + ++ T ++ APE Sbjct: 128 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 187 Query: 196 VI----LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 V+ + Y DIWS+G + EM + + + L +I K PP Sbjct: 188 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS--DPPTLLTP 245 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + S + L+ L + E R +A + L HP+ Sbjct: 246 --------------------------SKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV 279 Query: 312 ESLHDTE 318 S+ + Sbjct: 280 SSITSNK 286 >5LOH-A nrPDB Length = 341 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 68/321 (21%), Positives = 122/321 (38%), Gaps = 49/321 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR-PFQSELFAKRAYRELRLLKHMRH 83 + ++P+ GA+G V G G A+K + + ++ + E L + Sbjct: 36 EEFSIVKPISRGAFGKVYLGQKG--GKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-HEKLGEDRIQFLVYQMLKGL 141 ++ L +L + YLVM ++ G D+ L+ + E+ + ++ L Sbjct: 94 PFIVHLYY------SLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALAL 147 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS---------EMTGYVVTRWYR 192 Y+H GIIHRDLKP N+ ++ + +K+ DFGL++ + + T Y Sbjct: 148 DYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYL 207 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 APE++L + VD W++G + E +TG F + I+K Sbjct: 208 APELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK------------ 254 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 + S A + +E +L +D +R E HP F Sbjct: 255 ----------------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFS 298 Query: 313 SLHDTEDEPQVQKYDDSFDDV 333 + + Q + DD Sbjct: 299 DVDWENLQHQTMPFIPQPDDE 319 >4AF3-A nrPDB Length = 292 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 124/292 (42%), Gaps = 42/292 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHMRH 83 + +P+G G +G V A + ++ VA+K L++ + E + RE+ + H+ H Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHH 82 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 N++ L + F D YL++ + G +L K E R ++ ++ L Sbjct: 83 PNILRLYNYFY------DRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADAL 136 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS-EMTGYVVTRWYRAPEVILNW 200 Y H +IHRD+KP NL + ELKI DFG + A S T Y PE+I Sbjct: 137 MYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGR 196 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 M + + VD+W +G + E++ G F+ + H + + I+KV PA Sbjct: 197 M-HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTG-------- 247 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 A +L+ K+L + +R+ + AHP+ Sbjct: 248 -----------------------AQDLISKLLRHNPSERLPLAQVSAHPWVR 276 >6CQF-A nrPDB Length = 297 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 70/294 (23%), Positives = 126/294 (42%), Gaps = 41/294 (13%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + R Y LQ +G G YG V A D +G VA+K + + + +E+ +LK Sbjct: 13 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK--MEPDDDVSTLQKEILILKTC 70 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMK-HEKLGEDRIQFLVYQMLK 139 RH N++ + ++ M F G L + + L E +I ++ ++L+ Sbjct: 71 RHANIVAYHGSYLW------LQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQ 124 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT---GYVVTRWYRAPEV 196 GL Y+H+ IHRD+K N+ +N+ E+++ DFG++ Q + + ++ T ++ APEV Sbjct: 125 GLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEV 184 Query: 197 --ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 + Y + DIWS+G E+ + L L + K PP Sbjct: 185 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRL------ 238 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 EK +++ N ++ L ++R +A + L+H Sbjct: 239 -------------KEKGKWSAAFH-------NFIKVTLTKSPKKRPSATKMLSH 272 >5UNP-A nrPDB Length = 369 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 87/351 (24%), Positives = 156/351 (44%), Gaps = 55/351 (15%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTG-AKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 ++ Y + +G G +G V VD R G A+VA+K + E + + A E+ +L+ + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKI 88 Query: 82 RHEN------VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKLGEDRIQF 132 ++ + + D F D + +G +K + +++ Sbjct: 89 NEKDPDNKNLCVQMFDWF------DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLA-VNEDCE------------------LKILDFG 173 + +Q+ + ++++H + H DLKP N+ VN D E ++++DFG Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 174 LARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 A + V TR YRAPEVIL + ++Q D+WS+GCI+ E G TLF+ D+ + Sbjct: 203 SATFDHEHHSTIVSTRHYRAPEVILE-LGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNRE 261 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL---------- 283 L + ++ G P+ +++ + + + + + N PL Sbjct: 262 HLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEE 321 Query: 284 ---AVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFD 331 +L+E ML + +R+T GEAL HP+F L EP + +D S D Sbjct: 322 HHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRA---EPPNKLWDSSRD 369 >6E9W-A nrPDB Length = 443 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 116/301 (38%), Gaps = 46/301 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRH 83 Y ++ +G GA+G V T A+K L + + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 V+ L F D Y+VM +M G DL LM + + E +F +++ L Sbjct: 162 PWVVQLFYAFQDDR------YLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALD 215 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVIL 198 IH+ G IHRD+KP N+ +++ LK+ DFG + + E V T Y +PEV+ Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 199 ---NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Y + D WSVG + EM+ G T F + +IM Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN--------------- 320 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV---TAGEALAHPYFE 312 K + + S A NL+ L D E R+ E H +F+ Sbjct: 321 ------HKNSLTFPDDN------DISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFK 367 Query: 313 S 313 + Sbjct: 368 N 368 >6ED6-A nrPDB Length = 415 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 118/301 (39%), Gaps = 46/301 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY-RELRLLKHMRH 83 Y ++ +G GA+G V + A+K L + + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 V+ L F D Y+VM +M G DL LM + + E +F +++ L Sbjct: 148 PWVVQLFYAFQDDR------YLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALD 201 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWYRAPEVIL 198 IH+ G+IHRD+KP N+ +++ LK+ DFG + D V T Y +PEV+ Sbjct: 202 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 261 Query: 199 NWMR---YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 + Y + D WSVG + EM+ G T F + +IM + Sbjct: 262 SQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC--------- 312 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV---TAGEALAHPYFE 312 PE S A NL+ L D E R+ E HP+F+ Sbjct: 313 ---------FPE---------DAEISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFK 353 Query: 313 S 313 + Sbjct: 354 N 354 >5XVU-A nrPDB Length = 332 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 91/321 (28%), Positives = 163/321 (50%), Gaps = 23/321 (7%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 +Y + + W Y ++ +G G Y V + D A + K Sbjct: 16 EYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKK 70 Query: 70 RAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHEKLGE 127 + RE+++L+++ N+I LLD+ T L+ ++ D L + K + Sbjct: 71 KIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPS----LIFEYINNIDFKTL--YPKFTD 124 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QADSEMTG 184 I++ +YQ+LK L Y H+ GI+HRD+KP N+ ++ E+ +++++ +GLA E Sbjct: 125 KDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNV 184 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK-GSDHLDQLKEIMKVTG 243 V +R+Y+ PE++++ Y ++DIWS+GC++A MI K F G D+ DQL +I KV G Sbjct: 185 RVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLG 244 Query: 244 TPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLVLDAE 297 T ++++ +Y+ L E E+K ++ LT A ++L++KML+ D Sbjct: 245 TEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHA 304 Query: 298 QRVTAGEALAHPYFESLHDTE 318 +R+ EA+ HPYF + + Sbjct: 305 KRIAPKEAMEHPYFREVREES 325 >3RAW-A nrPDB Length = 381 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 78/332 (23%), Positives = 139/332 (41%), Gaps = 40/332 (12%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGA-KVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 ++ Y + +G G +G V +D G +VA+K + + + A E+ +LK + Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVG---KYREAARLEINVLKKI 105 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH---EKLGEDRIQFLVYQML 138 + ++ + + + +G + + +K + ++ + YQ+ Sbjct: 106 KEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVN-------------------EDCELKILDFGLARQAD 179 LR++H + H DLKP N+ ++ +++ DFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDH 225 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 T V TR YR PEVIL + + Q D+WS+GCI+ E G TLF+ ++ + L + Sbjct: 226 EHHTTIVATRHYRPPEVILE-LGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 284 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL-------------AVN 286 K+ G P+ + R + + + + D + N PL + Sbjct: 285 KILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFD 344 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 L+ +ML D QR+T EAL HP+F L E Sbjct: 345 LMRRMLEFDPAQRITLAEALLHPFFAGLTPEE 376 >4APC-A nrPDB Length = 350 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 137/329 (41%), Gaps = 52/329 (15%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q + K Y LQ +G G++G G + IK++ Sbjct: 9 SGVDLGTENLYFQSMEK--------YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINIS 60 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM 120 S + + RE+ +L +M+H N++ + F + +L Y+VM + G DL K + Sbjct: 61 RMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSL------YIVMDYCEGGDLFKRI 114 Query: 121 KHEK---LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ 177 +K ED+I Q+ L+++H I+HRD+K N+ + +D +++ DFG+AR Sbjct: 115 NAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARV 174 Query: 178 ADSEM---TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 +S + + T +Y +PE I Y DIW++GC++ E+ T K F+ + Sbjct: 175 LNSTVELARACIGTPYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNL 233 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 + +I ++G+ P + + S +L+ ++ Sbjct: 234 VLKI--ISGSFPP----------------------------VSLHYSYDLRSLVSQLFKR 263 Query: 295 DAEQRVTAGEALAHPYFESLHDTEDEPQV 323 + R + L + + PQ+ Sbjct: 264 NPRDRPSVNSILEKGFIAKRIEKFLSPQL 292 >3TKU-A nrPDB Length = 433 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 132/307 (42%), Gaps = 48/307 (15%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR-LLKHMR 82 R + ++ +G GA+G V T A+K L + + +RE R +L + Sbjct: 89 REDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGD 148 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKH--EKLGEDRIQFLVYQMLK 139 + + L F D YLVM + +G DL L+ +KL ED +F + +M+ Sbjct: 149 CQWITALHYAF------QDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 202 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY----VVTRWYRAPE 195 + IH +HRD+KP N+ ++ + +++ DFG + + + T V T Y +PE Sbjct: 203 AIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPE 262 Query: 196 VIL----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 ++ +Y D WS+G M EM+ G+T F ++ +IM Sbjct: 263 ILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHE--------- 313 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV---TAGEALAH 308 E+ F S +T+ S A +L+++ L+ E+R+ + H Sbjct: 314 -----------------ERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKH 355 Query: 309 PYFESLH 315 +FE L+ Sbjct: 356 AFFEGLN 362 >4C0T-A nrPDB Length = 974 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 83/346 (23%), Positives = 142/346 (41%), Gaps = 60/346 (17%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHEN 85 ++ + +G G+Y V A D TG + A+K L R E K E L + + Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR- 326 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRY 143 L V + T D Y V+ + G L + ++ L E+ + Q+L ++Y Sbjct: 327 ----LGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKY 382 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ------------ADSEMTGYVVTRWY 191 +H G+IHRDLKP N+ +++ ++I DFG AR D +V T Y Sbjct: 383 MHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEY 442 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 +PE++ N + D+W+ GCI+ +MI GK FK ++ ++I K+ A F Sbjct: 443 VSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPT 501 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + +L++K+LVL +R T E H +F Sbjct: 502 II-------------------------------RDLIKKILVLQPSRRATIPEIQKHYFF 530 Query: 312 ESLHDTE-------DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS 350 +S+ + D P++ Y + + + E + V+ Sbjct: 531 QSVDFKDFDSIWLSDPPEIGPYKMTAKSM-MKVPELNKAPITTVIK 575 >3FXW-A nrPDB Length = 336 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 71/351 (20%), Positives = 133/351 (37%), Gaps = 45/351 (12%) Query: 13 RQEVTKTAWEVRAVYRDLQ-PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 Q + V Y+ + +G G G V RTG K A+K LY + +A Sbjct: 16 FQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLY-------DSPKA 68 Query: 72 YRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLG 126 +E+ +++ +LDV+ + ++M M G +L ++ + Sbjct: 69 RQEVDHHWQASGGPHIVCILDVY--ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSE-M 182 E ++ + ++++H+ I HRD+KP NL +D LK+ DFG A++ + Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL 186 Query: 183 TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT 242 T +Y APEV+ +Y ++ D+WS+G IM ++ G F + Sbjct: 187 QTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG----------- 234 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 Q + + G +++ S A L+ +L D +R+T Sbjct: 235 --------QAISPGMKRRIRLGQYGFPNPEWS----EVSEDAKQLIRLLLKTDPTERLTI 282 Query: 303 GEALAHPYFESLHDTEDEP--QVQKYDDSFDDVDRTLDEWKRVTYKEVLSF 351 + + HP+ P + + D D +E + + Sbjct: 283 TQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDY 333 >3VN9-A nrPDB Length = 340 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 139/330 (42%), Gaps = 49/330 (14%) Query: 2 SSPPPARSGFYRQEVTKTAWEVR-AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 S+PP + +EV+ + +G GAYG V +G +A+K++ Sbjct: 27 STPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA 86 Query: 61 PFQSELFAKRAYRELRL-LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL 119 S+ KR +L + ++ + + + D ++ M M T L K Sbjct: 87 TVNSQEQ-KRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKF 139 Query: 120 MKH-----EKLGEDRIQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVNEDCELKILDFG 173 K + + ED + + ++K L ++H+ +IHRD+KP N+ +N ++K+ DFG Sbjct: 140 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 Query: 174 LARQADSEMTGYV--VTRWYRAPEVI---LNWMRYTQTVDIWSVGCIMAEMITGKTLFKG 228 ++ + + + Y APE I LN Y+ DIWS+G M E+ + + Sbjct: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-- 257 Query: 229 SDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLL 288 GTP + Q ++ + P+L F S V+ Sbjct: 258 -----------DSWGTPFQQLKQVVE--------EPSPQLPADKF-------SAEFVDFT 291 Query: 289 EKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 + L ++++R T E + HP+F +LH+++ Sbjct: 292 SQCLKKNSKERPTYPELMQHPFF-TLHESK 320 >4MD7-E nrPDB Length = 391 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 96/342 (28%), Positives = 173/342 (50%), Gaps = 35/342 (10%) Query: 1 MSSPPPARSGFYR------------QEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR 48 MS P P+R+ Y E W + Y+ ++ +G G Y V A++ Sbjct: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT 60 Query: 49 TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYL 107 K + + K+ RE+++L+++R N+I L D+ + L Sbjct: 61 NNEK-----VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----L 111 Query: 108 VMPFMG-TDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDC 165 V + TD +L ++ L + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ E Sbjct: 112 VFEHVNNTDFKQL--YQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHR 169 Query: 166 ELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 +L+++D+GLA E V +R+++ PE+++++ Y ++D+WS+GC++A MI K Sbjct: 170 KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRK 229 Query: 224 TL-FKGSDHLDQLKEIMKVTGTPP-AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-- 279 F G D+ DQL I KV GT +++ + + + L +K + + + Sbjct: 230 EPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSEN 289 Query: 280 ---ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 SP A++ L+K+L D + R+TA EA+ HPYF ++ + Sbjct: 290 QHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQ 331 >2PVN-A nrPDB Length = 352 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 154/320 (48%), Gaps = 19/320 (5%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 ++ E W + Y ++ VG G Y V ++ K + + + K Sbjct: 37 EYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKK 92 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR 129 L N++ LLD+ + L+ ++ K++ + L + Sbjct: 93 IKREIKILQNLCGGPNIVKLLDIVRDQHSKTPS----LIFEYVNNTDFKVL-YPTLTDYD 147 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLAR--QADSEMTGYV 186 I++ +Y++LK L Y H+ GI+HRD+KP N+ ++ + L+++D+GLA E V Sbjct: 148 IRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRV 207 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL-FKGSDHLDQLKEIMKVTGTP 245 +R+++ PE++++ Y ++D+WS+GC+ A MI K F G D+ DQL +I KV GT Sbjct: 208 ASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTD 267 Query: 246 P-AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLVLDAEQR 299 ++ + + + + +K + + SP A++ L+K+L D ++R Sbjct: 268 GLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQER 327 Query: 300 VTAGEALAHPYFESLHDTED 319 +TA EA+ HPYF+ + E+ Sbjct: 328 LTALEAMTHPYFQQVRAAEN 347 >6HMD-A nrPDB Length = 365 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 91/327 (27%), Positives = 174/327 (53%), Gaps = 23/327 (7%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAK 69 ++ E +W + Y+ ++ +G G Y V A++ ++ + K Sbjct: 38 EYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKK 92 Query: 70 RAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGE 127 + RE+++L+++R N+I L+D + LV ++ TD +L ++ L + Sbjct: 93 KIKREVKILENLRGGTNIIKLIDTVKDPVSKTPA----LVFEYINNTDFKQL--YQILTD 146 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE-DCELKILDFGLARQADS--EMTG 184 I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ +L+++D+GLA E Sbjct: 147 FDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNV 206 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL-FKGSDHLDQLKEIMKVTG 243 V +R+++ PE+++++ Y ++D+WS+GC++A MI + F G D+ DQL I KV G Sbjct: 207 RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 266 Query: 244 TPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLVLDAE 297 T ++++ D ++ L + +K + + + + SP A++LL+K+L D + Sbjct: 267 TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQ 326 Query: 298 QRVTAGEALAHPYFESLHDTEDEPQVQ 324 QR+TA EA+ HPYF + + +P Sbjct: 327 QRLTAKEAMEHPYFYPVVKEQSQPSAD 353 >5DYK-A nrPDB Length = 853 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 127/321 (39%), Gaps = 52/321 (16%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENV 86 + +G G +G V T + A+K + R + E + H + Sbjct: 542 ETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFI 601 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 I L+ T D FY + + G + K L + + QF + ++ + Y+ Sbjct: 602 IRLV------RTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYL 655 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT 204 H I++RDLKP N+ +++ +K++DFG A++ V T Y APEVIL Y Sbjct: 656 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILG-KGYG 714 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 TVDIW++G + E I G F G+D DQL EI + T F + ++ Sbjct: 715 CTVDIWALGICLYEFICGPLPF-GNDEEDQL-EIFRDILTGQLTFPDYVTDTDS------ 766 Query: 265 LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA-----GEALAHPYFESLH---- 315 +NL++++L + R+ + HP+F + + Sbjct: 767 --------------------INLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKL 806 Query: 316 -----DTEDEPQVQKYDDSFD 331 D + + Y + D Sbjct: 807 AGRLLDPPLVSKSETYAEDID 827 >4WNO-A nrPDB Length = 287 Score = 221 bits (563), Expect = 5e-58, Method: Composition-based stats. Identities = 81/325 (24%), Positives = 134/325 (41%), Gaps = 58/325 (17%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGA-KVAIKKLYR 60 S P R G + V K + + + +G GA+ V +VA+K + + Sbjct: 3 GSMEPGRGG--TETVGKFEFSRKDL------IGHGAFAVVFKGRHRAAHDLEVAVKCINK 54 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKL 119 ++ +E+++LK ++HEN++ L D + YLVM + G DL Sbjct: 55 KNLAKSQTL-LGKEIKILKELKHENIVALYDF------QEMANSVYLVMEYCNGGDLADY 107 Query: 120 MKHEK-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---------EDCELKI 169 + + L ED I+ + Q+ +R +H+ GIIHRDLKP N+ ++ +KI Sbjct: 108 LHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKI 167 Query: 170 LDFGLARQADSEM--TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK 227 DFG AR S M + Y APEVI++ Y D+WS+G I+ + +TGK F+ Sbjct: 168 ADFGFARYLQSNMMAATLCGSPMYMAPEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQ 226 Query: 228 GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNL 287 S D RL ++ K + +P +L Sbjct: 227 ASSPQDL-----------------RLFYEKNKTLVPTIPRETSAPLRQLLLALLQR---- 265 Query: 288 LEKMLVLDAEQRVTAGEALAHPYFE 312 + + R+ E HP+ + Sbjct: 266 -------NHKDRMDFDEFFHHPFLD 283 >1NY3-A nrPDB Length = 400 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 71/349 (20%), Positives = 133/349 (38%), Gaps = 46/349 (13%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGL 89 Q +G G G V + RT K A+K L +A RE+ L +++ + Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 120 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDRIQFLVYQMLKGLRYIH 145 +DV+ + +VM + G +L ++ + E ++ + + ++Y+H Sbjct: 121 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Query: 146 AAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNW 200 + I HRD+KP NL + LK+ DFG A++ S +T T +Y APEV+ Sbjct: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 +Y ++ D+WS+G IM ++ G F + L + Sbjct: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTR 278 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 G E +++ S L+ +L + QR+T E + HP+ Sbjct: 279 IRMGQYEFPNPEWS----EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 Query: 321 P--QVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 367 P + + + + +E + ++ ++ PL Sbjct: 335 PLHTSRVLKEDKERWEDVKEEMTSALATMRVDYE-QIKIKKIEDASNPL 382 >6QAU-A nrPDB Length = 280 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 81/301 (26%), Positives = 131/301 (43%), Gaps = 50/301 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDG-RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHEN 85 Y VG GA+ V +T +VAIK + + S+ +E+++LK ++HEN Sbjct: 13 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-LGKEIKILKELQHEN 71 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRY 143 ++ L DV + +LVM + G DL ++ L ED I+ ++Q+ +R Sbjct: 72 IVALYDV------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRI 125 Query: 144 IHAAGIIHRDLKPGNLAVN---------EDCELKILDFGLARQADSEM--TGYVVTRWYR 192 +H+ GIIHRDLKP N+ ++ +KI DFG AR S M + Y Sbjct: 126 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYM 185 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 APEVI++ Y D+WS+G ++ + + GK F+ + D Sbjct: 186 APEVIMS-QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD------------------- 225 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 ++ E + SI SP NLL +L + + R+ +HP+ E Sbjct: 226 ---------LRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLE 276 Query: 313 S 313 Sbjct: 277 Q 277 >4AW2-A nrPDB Length = 437 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 128/306 (41%), Gaps = 48/306 (15%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR-LLKHMR 82 R + L+ +G GA+G V A+K L + + +RE R +L + Sbjct: 73 REDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKH--EKLGEDRIQFLVYQMLK 139 + + L F D + YLVM + +G DL L+ ++L E+ +F + +M+ Sbjct: 133 SKWITTLHYAFQDD------NNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVI 186 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY----VVTRWYRAPE 195 + +H +HRD+KP N+ ++ + +++ DFG + + T V T Y +PE Sbjct: 187 AIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPE 246 Query: 196 VIL----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 ++ RY D WS+G M EM+ G+T F ++ +IM Sbjct: 247 ILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK--------- 297 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV---TAGEALAH 308 E+ F + +T+ S A +L+ + L+ E R+ + H Sbjct: 298 -----------------ERFQFPTQVTDVSENAKDLIRR-LICSREHRLGQNGIEDFKKH 339 Query: 309 PYFESL 314 P+F + Sbjct: 340 PFFSGI 345 >5FET-A nrPDB Length = 847 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 119/296 (40%), Gaps = 43/296 (14%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENV 86 + +G G +G V T + A+K + R S E + H + Sbjct: 536 ETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFI 595 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 I L+ T D FY + + G + K L + + QF + ++ + Y+ Sbjct: 596 IRLV------RTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYL 649 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT 204 H I++RDLKP N+ +++ +K++DFG A++ V T Y APEVIL Y Sbjct: 650 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTLVGTPHYMAPEVILG-KGYG 708 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 TVDIW++G + E I G F G+D DQL EI + T F + Sbjct: 709 CTVDIWALGVCLYEFICGPLPF-GNDQEDQL-EIFRDILTGQLTFPDYVS---------- 756 Query: 265 LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA-----GEALAHPYFESLH 315 ++NL++++L + R+ + H +F + + Sbjct: 757 ----------------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFN 796 >4RA4-A nrPDB Length = 355 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 128/316 (40%), Gaps = 55/316 (17%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAKRAYRELRLLKHMRHE- 84 + L +G G++G V A T AIK L + + + E R+L + Sbjct: 22 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 81 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 + L F + L Y VM ++ G DL ++ K E + F ++ GL Sbjct: 82 FLTQLHSCFQTVDRL------YFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 135 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 ++H GII+RDLK N+ ++ + +KI DFG+ ++ + T Y APE+I Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIA- 194 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + Y ++VD W+ G ++ EM+ G+ F G D + + IM+ + P Sbjct: 195 YQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSL---------- 244 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG-----EALAHPYF--- 311 S AV++ + ++ +R+ G + H +F Sbjct: 245 ---------------------SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI 283 Query: 312 --ESLHDTEDEPQVQK 325 E L + E +P + Sbjct: 284 DWEKLENREIQPPFKP 299 >2OZA-A nrPDB Length = 356 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 71/349 (20%), Positives = 133/349 (38%), Gaps = 46/349 (13%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGL 89 Q +G G G V + RT K A+K L +A RE+ L +++ + Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 76 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDRIQFLVYQMLKGLRYIH 145 +DV+ + +VM + G +L ++ + E ++ + + ++Y+H Sbjct: 77 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 146 AAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNW 200 + I HRD+KP NL + LK+ DFG A++ S +T T +Y APEV+ Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 193 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 +Y ++ D+WS+G IM ++ G F + L + Sbjct: 194 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTR 234 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 G E +++ S L+ +L + QR+T E + HP+ Sbjct: 235 IRMGQYEFPNPEWS----EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 290 Query: 321 P--QVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETPL 367 P + + + + +E + ++ ++ PL Sbjct: 291 PLHTSRVLKEDKERWEDVKEEMTSALATMRVDYE-QIKIKKIEDASNPL 338 >3KA0-A nrPDB Length = 320 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 69/332 (20%), Positives = 127/332 (38%), Gaps = 45/332 (13%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGL 89 Q +G G G V + RT K A+K L +A RE+ L +++ + Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 74 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDRIQFLVYQMLKGLRYIH 145 +DV+ + +VM + G +L ++ + E ++ + + ++Y+H Sbjct: 75 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 132 Query: 146 AAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNW 200 + I HRD+KP NL + LK+ DFG A++ S +T T +Y APEV+ Sbjct: 133 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GP 191 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 +Y ++ D+WS+G IM ++ G F + L + Sbjct: 192 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTR 232 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 G E +++ S L+ +L + QR+T E + HP+ Sbjct: 233 IRMGQYEFPNPEWS----EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 288 Query: 321 PQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 P + ++ K + + + Sbjct: 289 PL--HTSRVLKEDKERWEDVKEEMTSALATMR 318 >3A8W-A nrPDB Length = 345 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 140/349 (40%), Gaps = 43/349 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAKRAYRELRLLKHM-RHE 84 + L+ +G G+Y V +T A+K + + + E + + H Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 70 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDL-GKLMKHEKLGEDRIQFLVYQMLKGLR 142 ++GL F + L + V+ ++ G DL + + KL E+ +F ++ L Sbjct: 71 FLVGLHSCFQTESRL------FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALN 124 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 Y+H GII+RDLK N+ ++ + +K+ D+G+ ++ + + T Y APE++ Sbjct: 125 YLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Y +VD W++G +M EM+ G++ F I+ + P L + Sbjct: 185 -EDYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQNTEDYLFQVILE 233 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA------GEALAHPYFES 313 ++ I + S A ++L+ L D ++R+ + HP+F + Sbjct: 234 KQIR------------IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRN 281 Query: 314 LH-DTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARV 361 + D ++ QV + LD + E + P R Sbjct: 282 VDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRK 330 >2H8H-A nrPDB Length = 535 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 80/322 (24%), Positives = 132/322 (40%), Gaps = 55/322 (17%) Query: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY 72 Q + K AWE+ R R +G G +G V T +VAIK L S + Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFL 310 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK---LGED 128 +E +++K +RHE ++ L V + + Y+V +M L +K E L Sbjct: 311 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLP 363 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVV 187 ++ + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T Sbjct: 364 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 423 Query: 188 TRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTG 243 ++ + APE L + R+T D+WS G ++ E+ T G+ + G + + L ++ + Sbjct: 424 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 482 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 P +L+ + + E+R T Sbjct: 483 MPCP------------------------------PECPESLHDLMCQCWRKEPEERPTF- 511 Query: 304 EALAHPYFESLHDTEDEPQVQK 325 E L + E T EPQ Q Sbjct: 512 EYLQ-AFLEDYF-TSTEPQYQP 531 >4TNB-A nrPDB Length = 590 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 81/322 (25%), Positives = 139/322 (43%), Gaps = 52/322 (16%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 RQ VTK +R + +G G +G VC+ TG A K+L + + + Sbjct: 176 LERQPVTKNT------FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGES 229 Query: 71 -AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKL 125 A E ++L+ + + V+ L + + L LV+ M G DL + + Sbjct: 230 MALNEKQILEKVNSQFVVNLAYAYETKDAL------CLVLTIMNGGDLKFHIYNMGNPGF 283 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MT 183 E+R F ++L GL +H ++RDLKP N+ +++ ++I D GLA + + Sbjct: 284 EEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR 343 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 G V T Y APEV+ N RY + D W +GC++ EMI G++ F+G + +E+ + Sbjct: 344 GRVGTVGYMAPEVL-NNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVL 402 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV--- 300 + + S A ++ + +L DA+QR+ Sbjct: 403 ETEEVYSHKF---------------------------SEEAKSICKMLLTKDAKQRLGCQ 435 Query: 301 --TAGEALAHPYFESLHDTEDE 320 A E HP+F +++ E Sbjct: 436 EEEAAEVKRHPFFRNMNFKRLE 457 >6F3F-A nrPDB Length = 455 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 80/322 (24%), Positives = 132/322 (40%), Gaps = 55/322 (17%) Query: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY 72 Q + K AWE+ R R +G G +G V T +VAIK L S + Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFL 230 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK---LGED 128 +E +++K +RHE ++ L V + + Y+V +M L +K E L Sbjct: 231 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMNKGSLLDFLKGETGKYLRLP 283 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVV 187 ++ + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T Sbjct: 284 QLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 343 Query: 188 TRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTG 243 ++ + APE L + R+T D+WS G ++ E+ T G+ + G + + L ++ + Sbjct: 344 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 402 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 P +L+ + + E+R T Sbjct: 403 MPCP------------------------------PECPESLHDLMCQCWRKEPEERPTF- 431 Query: 304 EALAHPYFESLHDTEDEPQVQK 325 E L + E T EPQ Q Sbjct: 432 EYLQ-AFLEDYF-TSTEPQYQP 451 >6EII-A nrPDB Length = 352 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 91/318 (28%), Positives = 167/318 (52%), Gaps = 23/318 (7%) Query: 9 SGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA 68 S ++ E W + Y+ ++ +G G Y V A++ K + + Sbjct: 44 SEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKK 98 Query: 69 KRAYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLG 126 K+ RE+++L+++R N+I L D+ + LV + TD +L ++ L Sbjct: 99 KKIKREIKILENLRGGPNIITLADIVKDPVSRTPA----LVFEHVNNTDFKQL--YQTLT 152 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QADSEMT 183 + I+F +Y++LK L Y H+ GI+HRD+KP N+ ++ E +L+++D+GLA E Sbjct: 153 DYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYN 212 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL-FKGSDHLDQLKEIMKVT 242 V +R+++ PE+++++ Y ++D+WS+GC++A MI K F G D+ DQL I KV Sbjct: 213 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVL 272 Query: 243 GTPP-AEFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLVLDA 296 GT +++ + + + L +K + + + SP A++ L+K+L D Sbjct: 273 GTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDH 332 Query: 297 EQRVTAGEALAHPYFESL 314 + R+TA EA+ HPYF ++ Sbjct: 333 QSRLTAREAMEHPYFYTV 350 >4CRL-A nrPDB Length = 406 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 97/328 (29%), Positives = 150/328 (45%), Gaps = 47/328 (14%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAK--VAIKKLYRPFQSELFAKRAYRELRLLK 79 E Y + G G YG V A A+K++ + + A RE+ LL+ Sbjct: 20 EDLFEYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLR 74 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK----------LGEDR 129 ++H NVI L VF +L+ + DL ++K + L Sbjct: 75 ELKHPNVISLQKVFLS----HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGM 130 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV----NEDCELKILDFGLARQADSEMTGY 185 ++ L+YQ+L G+ Y+HA ++HRDLKP N+ V E +KI D G AR +S + Sbjct: 131 VKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPL 190 Query: 186 ------VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK---------GSD 230 VVT WYRAPE++L YT+ +DIW++GCI AE++T + +F Sbjct: 191 ADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPY 250 Query: 231 HLDQLKEIMKVTGTPPAEFVQRLQS-DEAKNYMKGLPELEKKDFASI------LTNASPL 283 H DQL I V G P + + ++ E MK + + I Sbjct: 251 HHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSK 310 Query: 284 AVNLLEKMLVLDAEQRVTAGEALAHPYF 311 A +LL+K+L +D +R+T+ +A+ PYF Sbjct: 311 AFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >3ALO-A nrPDB Length = 327 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 131/318 (41%), Gaps = 48/318 (15%) Query: 18 KTAWEVR-AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 + W+ +DL +G GAYG+V V +G +A+K++ E K+ +L Sbjct: 14 EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV-DEKEQKQLLMDLD 72 Query: 77 L-LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH------EKLGEDR 129 + ++ ++ + D ++ M M T K K+ + + E+ Sbjct: 73 VVMRSSDCPYIVQFYGALFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEI 126 Query: 130 IQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM--TGYV 186 + + +K L ++ IIHRD+KP N+ ++ +K+ DFG++ Q + T Sbjct: 127 LGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA 186 Query: 187 VTRWYRAPEVI---LNWMRYTQTVDIWSVGCIMAEMITGKTLFK-GSDHLDQLKEIMKVT 242 R Y APE I + Y D+WS+G + E+ TG+ + + DQL +++K Sbjct: 187 GCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK-- 244 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 G PP L E+++F SP +N + L D +R Sbjct: 245 GDPPQ-----------------LSNSEEREF-------SPSFINFVNLCLTKDESKRPKY 280 Query: 303 GEALAHPYFESLHDTEDE 320 E L HP+ + E Sbjct: 281 KELLKHPFILMYEERAVE 298 >6E2O-A nrPDB Length = 295 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 129/290 (44%), Gaps = 44/290 (15%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G YG V + D ++AIK++ P + +++ + E+ L KH++H+N++ L Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 92 VFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAA 147 F+ + + F + G L L++ + K E I F Q+L+GL+Y+H Sbjct: 87 SFSENGFIKIFMEQV-----PGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN 141 Query: 148 GIIHRDLKPGNLAVNE-DCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVI-LNWMR 202 I+HRD+K N+ +N LKI DFG +++ + + T Y APE+I Sbjct: 142 QIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRG 201 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 Y + DIWS+GC + EM TGK F L +A + Sbjct: 202 YGKAADIWSLGCTIIEMATGKPPFY------------------------ELGEPQAAMFK 237 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 G+ ++ + I + S A + K D ++R A + L + + Sbjct: 238 VGMFKVHPE----IPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >5MJB-A nrPDB Length = 305 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 122/310 (39%), Gaps = 28/310 (9%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDGRTGAK---VAIK 56 M + V + A E+ + + + +G+G +G V G + VAIK Sbjct: 1 MGHHHHHHGSDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIK 60 Query: 57 KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL 116 L + SE + E ++ H N+I L V T + T+F M D Sbjct: 61 TLKAGY-SEKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEF---MENCALDS 116 Query: 117 GKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR 176 + ++ ++ + G++Y+ +HRDL N+ VN + K+ DFGL+R Sbjct: 117 FLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR 176 Query: 177 QADSEMTGYVVT--------RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFK 227 + + T + APE I + ++T D+WS G +M E+++ G+ + Sbjct: 177 YLQDDTSDPTYTSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGERPYW 235 Query: 228 GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNL 287 + D + I + PP + + + +KD S A VN Sbjct: 236 DMSNQDVINAIEQDYRLPPPMDCPA-------ALHQLMLDCWQKDRNSRPRFA--EIVNT 286 Query: 288 LEKMLVLDAE 297 L+KM+ + Sbjct: 287 LDKMI-RNPA 295 >2WQN-A nrPDB Length = 310 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 121/316 (38%), Gaps = 52/316 (16%) Query: 1 MSSPPPARSGFYRQEVT--KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL 58 M PP F Q+ + A +R + +G G + V A G VA+KK+ Sbjct: 8 MQGPP--VPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKV 65 Query: 59 YR-PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDL 116 +E+ LLK + H NVI F D L+ +V+ DL Sbjct: 66 QIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELN------IVLELADAGDL 119 Query: 117 GKLMKHEK-----LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILD 171 +++KH K + E + Q+ L ++H+ ++HRD+KP N+ + +K+ D Sbjct: 120 SRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGD 179 Query: 172 FGLARQADSEMT---GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG 228 GL R S+ T V T +Y +PE I + Y DIWS+GC++ EM ++ F G Sbjct: 180 LGLGRFFSSKTTAAHSLVGTPYYMSPERI-HENGYNFKSDIWSLGCLLYEMAALQSPFYG 238 Query: 229 S--DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN 286 + K+I + P + S Sbjct: 239 DKMNLYSLCKKIEQCDYPPLPSD-----------------------------HYSEELRQ 269 Query: 287 LLEKMLVLDAEQRVTA 302 L+ + D E+R Sbjct: 270 LVNMCINPDPEKRPDV 285 >5SYS-A nrPDB Length = 286 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 80/322 (24%), Positives = 131/322 (40%), Gaps = 55/322 (17%) Query: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY 72 Q + K AWE+ R R +G G +G T +VAIK L S + Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMS---PEAFL 61 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE---KLGED 128 +E +++K +RHE ++ L V + + Y+V +M L +K E L Sbjct: 62 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGEMGKYLRLP 114 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVV 187 ++ + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T Sbjct: 115 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 174 Query: 188 TRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTG 243 ++ + APE L + R+T D+WS G ++ E+ T G+ + G + + L ++ + Sbjct: 175 AKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 233 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 P +L+ + D E+R T Sbjct: 234 MPCP------------------------------PECPESLHDLMCQCWRKDPEERPTF- 262 Query: 304 EALAHPYFESLHDTEDEPQVQK 325 E L + E T EPQ Q Sbjct: 263 EYLQ-AFLEDYF-TSTEPQYQP 282 >4XEY-B nrPDB Length = 408 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 67/326 (20%), Positives = 120/326 (36%), Gaps = 52/326 (15%) Query: 4 PPPARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 P + Y WE+ R +G G YG V V + VA+K L Sbjct: 103 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--- 159 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL- 119 + + + +E ++K ++H N++ LL V T + FY++ FM G L L Sbjct: 160 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLR 213 Query: 120 -MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 +++ + ++ Q+ + Y+ IHRDL N V E+ +K+ DFGL+R Sbjct: 214 ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM 273 Query: 179 -DSEMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLD 233 T + ++ + APE + + +++ D+W+ G ++ E+ T G + + G D Sbjct: 274 TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 332 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 + LEK L+ Sbjct: 333 VYEL------------------------------LEKDYRMERPEGCPEKVYELMRACWQ 362 Query: 294 LDAEQRVTAGEALAHPYFESLHDTED 319 + R + E H FE++ Sbjct: 363 WNPSDRPSFAEI--HQAFETMFQESS 386 >2FO0-A nrPDB Length = 495 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 120/326 (36%), Gaps = 52/326 (15%) Query: 4 PPPARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 P + Y WE+ R +G G YG V V + VA+K L Sbjct: 195 PKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK--- 251 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL- 119 + + + +E ++K ++H N++ LL V T + FY++ FM G L L Sbjct: 252 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLR 305 Query: 120 -MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 +++ + ++ Q+ + Y+ IHR+L N V E+ +K+ DFGL+R Sbjct: 306 ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLM 365 Query: 179 -DSEMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLD 233 T + ++ + APE + + +++ D+W+ G ++ E+ T G + + G D Sbjct: 366 TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ 424 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 + LEK L+ Sbjct: 425 VYEL------------------------------LEKDYRMERPEGCPEKVYELMRACWQ 454 Query: 294 LDAEQRVTAGEALAHPYFESLHDTED 319 + R + E H FE++ Sbjct: 455 WNPSDRPSFAEI--HQAFETMFQESS 478 >2BRG-A nrPDB Length = 297 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 121/293 (41%), Gaps = 42/293 (14%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +Q +G GAYG V AV+ T VA+K + + + +E+ + K + HENV+ Sbjct: 10 DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDC-PENIKKEICINKMLNHENVV 68 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 + YL + + G ++ + E Q +Q++ G+ Y+H Sbjct: 69 KFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSE--MTGYVVTRWYRAPEVILNW 200 GI HRD+KP NL ++E LKI DFGLA R + E + T Y APE++ Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 + + VD+WS G ++ M+ G+ + Q + E K Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQ----------------EYSDWKEKKT 226 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 Y+ +++ A LL K+LV + R+T + ++ Sbjct: 227 YLNPWKKIDSAPLA------------LLHKILVENPSARITIPDIKKDRWYNK 267 >2WTK-C nrPDB Length = 305 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 132/323 (40%), Gaps = 47/323 (14%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA--YRELRLLK 79 ++ Y +G G+YG V +D T + A+K L + + A +E++LL+ Sbjct: 2 KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLR 61 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH---EKLGEDRIQFLVYQ 136 +RH+NVI L+DV +E Y+VM + + +++ ++ + Q Sbjct: 62 RLRHKNVIQLVDVLYNEEK----QKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQ 117 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-----DSEMTGYVVTRWY 191 ++ GL Y+H+ GI+H+D+KPGNL + LKI G+A D + + Sbjct: 118 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAF 177 Query: 192 RAPEVILNWMRYT-QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + PE+ ++ VDIWS G + + TG F+G + + I K + P Sbjct: 178 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIP---- 233 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 + P +LL+ ML + +R + + H + Sbjct: 234 ---------------------------GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 266 Query: 311 FESLHDTEDEP-QVQKYDDSFDD 332 F H + P + D+ D Sbjct: 267 FRKKHPPAEAPVPIPPSPDTKDR 289 >6BDL-A nrPDB Length = 347 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 124/300 (41%), Gaps = 47/300 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDG-RTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRHE 84 + + +G G +G V A+K L + + + R E ++++ + Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMP-FMGTDLGKLMK-HEKLGEDRIQFLVYQMLKGLR 142 ++ L T D Y++M +G +L +++ + +F +++ Sbjct: 96 FIVRLY------RTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILNW 200 Y+H+ GII+RDLKP NL ++ K++DFG A++ + + T Y APE+ILN Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN- 208 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 + + D WS+G +M E++TG F G D + I++ Sbjct: 209 KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI------------------ 250 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYFESLH 315 + E KK + A NL++K+ + +R+ + H +FE + Sbjct: 251 ---DMIEFPKK--------IAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFN 299 >6CCF-A nrPDB Length = 290 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 128/317 (40%), Gaps = 63/317 (19%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR------------------------PF 62 Y+ +G GAYG V A + A+K L + P Sbjct: 7 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPA 66 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK 121 + L +R Y+E+ +LK + H NV+ L++V D+ +D + YLV + + ++ Sbjct: 67 KQLLPLERVYQEIAILKKLDHVNVVKLIEVL--DDPAED--NLYLVFDLLRKGPVMEVPC 122 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--- 178 + E++ + + ++ GL Y+H I+HRD+KP NL + +D +KI DFG++ Q Sbjct: 123 DKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN 182 Query: 179 DSEMTGYVVTRWYRAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 D++++ T + APE I + +D+W+ G + + GK F L + Sbjct: 183 DAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHR 242 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 +I P E S +L+ KML + Sbjct: 243 KIKNEPVVFPEE-----------------------------PEISEELKDLILKMLDKNP 273 Query: 297 EQRVTAGEALAHPYFES 313 E R+ + HP+ Sbjct: 274 ETRIGVPDIKLHPWVTK 290 >3PPZ-A nrPDB Length = 309 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 124/333 (37%), Gaps = 54/333 (16%) Query: 6 PARSGFYRQEVT-KTAWEVR-AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ 63 P Y Q ++ + +G+G++G V A G+ VA+K L Sbjct: 16 PTTENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDF 73 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMK- 121 RE+ ++K +RH N++ + T L +V ++ L +L+ Sbjct: 74 HAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLS------IVTEYLSRGSLYRLLHK 127 Query: 122 ---HEKLGEDRIQFLVYQMLKGLRYIHAAG--IIHRDLKPGNLAVNEDCELKILDFGLAR 176 E+L E R + Y + KG+ Y+H I+HRDLK NL V++ +K+ DFGL+R Sbjct: 128 SGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSR 187 Query: 177 QADSEM---TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 S T + APEV+ + + D++S G I+ E+ T + + + Sbjct: 188 LKASTFLSSKSAAGTPEWMAPEVLRD-EPSNEKSDVYSFGVILWELATLQQPWGNLNPAQ 246 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 + + K I N +P ++E Sbjct: 247 VVAAVG-----------------------------FKCKRLEIPRNLNPQVAAIIEGCWT 277 Query: 294 LDAEQRV---TAGEALAHPYFESLHDTEDEPQV 323 + +R T + L P +S + + Sbjct: 278 NEPWKRPSFATIMDLLR-PLIKSAVPPPNRSDL 309 >3FME-A nrPDB Length = 290 Score = 210 bits (535), Expect = 7e-55, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 126/305 (41%), Gaps = 47/305 (15%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL-LKHMRHENV 86 + +G GAYG V +G +A+K++ S+ KR +L + ++ + Sbjct: 10 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ-KRLLMDLDISMRTVDCPFT 68 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQFLVYQMLKGL 141 + + D ++ M M T L K K + + ED + + ++K L Sbjct: 69 VTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 122 Query: 142 RYIHAA-GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV--VTRWYRAPEVI- 197 ++H+ +IHRD+KP N+ +N ++K+ DFG++ ++ + + Y APE I Sbjct: 123 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 198 --LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 LN Y+ DIWS+G M E+ + + GTP + Q ++ Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSWGTPFQQLKQVVE- 228 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 + P+L F S V+ + L ++++R T E + HP+F Sbjct: 229 -------EPSPQLPADKF-------SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 274 Query: 316 DTEDE 320 + Sbjct: 275 SKGTD 279 >5L6P-A nrPDB Length = 298 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 63/288 (21%), Positives = 117/288 (40%), Gaps = 19/288 (6%) Query: 12 YRQEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRPFQSELF 67 + V + A E+ + + +G+G +G VC + G + VAIK L + +E Sbjct: 5 PNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGY-TERQ 63 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 + E ++ H N+I L V T + T+F M D + + Sbjct: 64 RRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEF---MENCALDSFLRLNDGQFTV 120 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 ++ ++ + G++Y+ +HRDL N+ VN + K+ DFGL+R + + + Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 188 T--------RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 T + APE I + ++T D+WS G +M E+++ G+ + + D + + Sbjct: 181 TSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAV 239 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN 286 + PP + L K F+ I+ L N Sbjct: 240 EQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPK-FSQIVNTLDKLIRN 286 >2XYN-A nrPDB Length = 292 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 115/313 (36%), Gaps = 52/313 (16%) Query: 2 SSPPPARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 S Y Q + K WE+ R +G G YG V V + VA+K L Sbjct: 10 SGVDLGTENLYFQSMDK--WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK- 66 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGK 118 + + + +E ++K ++H N++ LL V T + FY+V +M G L Sbjct: 67 --EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP------FYIVTEYMPYGNLLDY 118 Query: 119 L--MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR 176 L E++ + ++ Q+ + Y+ IHRDL N V E+ +K+ DFGL+R Sbjct: 119 LRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR 178 Query: 177 QA-DSEMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 T + ++ + APE + + ++ D+W+ G ++ E+ T G + + G D Sbjct: 179 LMTGDTYTAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 237 Query: 232 LDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKM 291 + K E P L+ Sbjct: 238 SQVYDLLEKGYRMEQPE------------------------------GCPPKVYELMRAC 267 Query: 292 LVLDAEQRVTAGE 304 R + E Sbjct: 268 WKWSPADRPSFAE 280 >4IAN-A nrPDB Length = 358 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 86/349 (24%), Positives = 157/349 (44%), Gaps = 55/349 (15%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDG-RTGAKVAIKKLYRPFQSE 65 G+YR + + + Y G G + V A D R +VA+K + +E Sbjct: 15 DAEGYYRVNIGEV---LDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNE 68 Query: 66 LFAKRAYRELRLLKHMRHE------NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL 119 L K +EL LK + + + L F + LV + +L ++ Sbjct: 69 LMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQ------HLCLVFEPLSMNLREV 122 Query: 120 MKHEK----LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL-KILDFGL 174 +K L ++ Q+ L+ + I+H D+KP N+ VNE + K+ DFG Sbjct: 123 LKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGS 182 Query: 175 ARQA-DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 A D+++T Y+V+R+YRAPE+I+ Y +D+WSVGC + E+ TGK LF G + Sbjct: 183 ASHVADNDITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNH 241 Query: 234 QLKEIMKVTGTPPAEFVQR-----LQSDEAKNYMK-GLPELEKKDFASILTNASP----- 282 LK M + G P + +++ D+ N+M + ++ +++ ++++ +P Sbjct: 242 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL 301 Query: 283 ------------------LAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 +LL+++L+LD +R++ +AL H + + Sbjct: 302 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >5KKR-C nrPDB Length = 395 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 125/313 (39%), Gaps = 25/313 (7%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + + +G+G G V +G +A K ++ + + + REL++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSP 126 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 ++G F D + + M M G L +++K ++ E + + ++KGL Sbjct: 127 YIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 180 Query: 143 YI-HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNW 200 Y+ I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y +PE + Sbjct: 181 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG- 239 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ-----------LKEIMKVTGTPPAEF 249 Y+ DIWS+G + EM G+ D + E TP Sbjct: 240 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 299 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNA--SPLAVNLLEKMLVLDAEQRVTAGEALA 307 + L + + L +A S + + K L+ + +R + + Sbjct: 300 SSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMV 359 Query: 308 HPYFESLHDTEDE 320 H + + E + Sbjct: 360 HAFIKRSDAEEVD 372 >3PFQ-A nrPDB Length = 674 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 125/316 (39%), Gaps = 55/316 (17%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAKRAYRELRLLKH-MRHE 84 + L +G G++G V + T A+K L + + + E R+L + Sbjct: 343 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 402 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 + L F + L Y VM ++ G DL ++ + E F ++ GL Sbjct: 403 FLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 456 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 ++ + GII+RDLK N+ ++ + +KI DFG+ ++ + T Y APE+I Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA- 515 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + Y ++VD W+ G ++ EM+ G+ F+G D + + IM+ P Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------- 565 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG-----EALAHPYF--- 311 S AV + + ++ +R+ G + H +F Sbjct: 566 ---------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 604 Query: 312 --ESLHDTEDEPQVQK 325 E L E +P + Sbjct: 605 DWEKLERKEIQPPYKP 620 >6NPU-A nrPDB Length = 298 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 119/322 (36%), Gaps = 53/322 (16%) Query: 9 SGFYRQEVTK-TAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 Y Q WE+ R +G G YG V V + VA+K L + + Sbjct: 8 ENLYFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK---EDTM 64 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKL--MKH 122 + +E ++K ++H N++ LL V T + FY++ FM G L L Sbjct: 65 EVEEFLKEAAVMKEIKHPNLVQLLGVCTREPP------FYIITEFMTYGNLLDYLRECNR 118 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSE 181 +++ + ++ Q+ + Y+ IHRDL N V E+ +K+ DFGL+R Sbjct: 119 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT 178 Query: 182 MTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKE 237 T + ++ + APE + + +++ D+W+ G ++ E+ T G + + G D + Sbjct: 179 YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYEL 237 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 LEK L+ + Sbjct: 238 ------------------------------LEKDYRMERPEGCPEKVYELMRACWQWNPS 267 Query: 298 QRVTAGEALAHPYFESLHDTED 319 R + E H FE++ Sbjct: 268 DRPSFAEI--HQAFETMFQESS 287 >4FR4-A nrPDB Length = 384 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 129/301 (42%), Gaps = 46/301 (15%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-AYRELRLLKHMRH 83 + L+ +G G++G VC T A+K + + E R ++EL++++ + H Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH 74 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL-GKLMKHEKLGEDRIQFLVYQMLKGLR 142 ++ L F +E + F +V +G DL L ++ E+ ++ + +++ L Sbjct: 75 PFLVNLWYSFQDEEDM-----FMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALD 129 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--DSEMTGYVVTRWYRAPEVILNW 200 Y+ IIHRD+KP N+ ++E + I DF +A ++++T T+ Y APE+ + Sbjct: 130 YLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR 189 Query: 201 M--RYTQTVDIWSVGCIMAEMITGKTLFK---GSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Y+ VD WS+G E++ G+ + + + + T P+ + Q + S Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 249 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT-AGEALAHPYFESL 314 LL+K+L + +QR + + PY + Sbjct: 250 -------------------------------LLKKLLEPNPDQRFSQLSDVQNFPYMNDI 278 Query: 315 H 315 + Sbjct: 279 N 279 >2VD5-A nrPDB Length = 412 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 67/325 (20%), Positives = 123/325 (37%), Gaps = 50/325 (15%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR-LLKHMR 82 R + L+ +G GA+ V +TG A+K + + + +RE R +L + Sbjct: 60 RDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 119 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKH--EKLGEDRIQFLVYQMLK 139 + L F D YLVM + +G DL L+ E++ + +F + +++ Sbjct: 120 RRWITQLHFAF------QDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 173 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY----VVTRWYRAPE 195 + +H G +HRD+KP N+ ++ +++ DFG + ++ T V T Y +PE Sbjct: 174 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 233 Query: 196 VIL------NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 ++ Y D W++G EM G+T F + +I+ Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 293 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV---TAGEAL 306 V A + ++++L E R+ AG+ Sbjct: 294 VDE--------------------------GVPEEARDFIQRLLCP-PETRLGRGGAGDFR 326 Query: 307 AHPYFESLHDTEDEPQVQKYDDSFD 331 HP+F L V + F+ Sbjct: 327 THPFFFGLDWDGLRDSVPPFTPDFE 351 >2DQ7-X nrPDB Length = 283 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 76/318 (23%), Positives = 128/318 (40%), Gaps = 55/318 (17%) Query: 18 KTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 K WE+ R + ++ +G+G +G V KVAIK L S + E + Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS---PESFLEEAQ 56 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK---LGEDRIQF 132 ++K ++H+ ++ L V + + Y+V +M L +K + L + Sbjct: 57 IMKKLKHDKLVQLYAVVSEEP-------IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVD 109 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW- 190 + Q+ G+ YI IHRDL+ N+ V KI DFGLAR D+E T ++ Sbjct: 110 MAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFP 169 Query: 191 --YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPA 247 + APE L + R+T D+WS G ++ E++T G+ + G ++ + L+++ + P Sbjct: 170 IKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 228 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + L+ D E+R T E L Sbjct: 229 QDCPI------------------------------SLHELMIHCWKKDPEERPTF-EYLQ 257 Query: 308 HPYFESLHDTEDEPQVQK 325 + E EPQ Q Sbjct: 258 -SFLEDYFTA-TEPQYQP 273 >2XNP-A nrPDB Length = 279 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 120/301 (39%), Gaps = 49/301 (16%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 Y L +G+G+YG G + K+L +E + E+ LL+ ++H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM-----KHEKLGEDRIQFLVYQML 138 N++ D T Y+VM + G DL ++ + + L E+ + ++ Q+ Sbjct: 66 NIVRYYDRIIDRT----NTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLT 121 Query: 139 KGLRYIHA-----AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM---TGYVVTRW 190 L+ H ++HRDLKP N+ ++ +K+ DFGLAR + + +V T + Sbjct: 122 LALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY 181 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 Y +PE +N M Y + DIWS+GC++ E+ F + +I + Sbjct: 182 YMSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGK-------- 232 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 F I S ++ +ML L R + E L +P Sbjct: 233 ----------------------FRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270 Query: 311 F 311 Sbjct: 271 I 271 >3EQC-A nrPDB Length = 360 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 124/313 (39%), Gaps = 25/313 (7%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + + +G+G G V +G +A K ++ + + + REL++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSP 91 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 ++G F D + + M M G L +++K ++ E + + ++KGL Sbjct: 92 YIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 145 Query: 143 YI-HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNW 200 Y+ I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y +PE + Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG- 204 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y+ DIWS+G + EM G+ D + AE R ++ Sbjct: 205 THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPL 264 Query: 261 YMKGLPELEKKDFASILTNA-------------SPLAVNLLEKMLVLDAEQRVTAGEALA 307 G+ +L S + + K L+ + +R + + Sbjct: 265 NKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMV 324 Query: 308 HPYFESLHDTEDE 320 H + + E + Sbjct: 325 HAFIKRSDAEEVD 337 >2Y6O-A nrPDB Length = 291 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 128/302 (42%), Gaps = 34/302 (11%) Query: 14 QEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRPFQSELFAK 69 Q V + A E+ A + + +G G +G VCS G + VAIK L + ++ + Sbjct: 2 QAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGY-TDKQRR 60 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLG 126 E ++ H N+I L V T + ++ +M L ++ + Sbjct: 61 DFLSEASIMGQFDHPNIIHLEGVVTKCKP------VMIITEYMENGSLDAFLRKNDGRFT 114 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV 186 ++ ++ + G++Y+ +HRDL N+ VN + K+ DFG++R + + Sbjct: 115 VIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 174 Query: 187 VTRW------YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIM 239 TR + APE I + ++T D+WS G +M E+++ G+ + + D +K I Sbjct: 175 TTRGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE 233 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE-- 297 + PP + + + +K+ + VN+L+K L+ + Sbjct: 234 EGYRLPPPMDCP-------IALHQLMLDCWQKERSDRPKFG--QIVNMLDK-LIRNPNSL 283 Query: 298 QR 299 +R Sbjct: 284 KR 285 >4OLI-A nrPDB Length = 645 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 63/306 (20%), Positives = 122/306 (39%), Gaps = 38/306 (12%) Query: 24 RAVYRDLQPVGSGAYGAV----CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 + + ++ +G G +G V + TG VA+K L + +E+ +L+ Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADCGPQHRSGWKQEIDILR 410 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQML 138 + HE++I LVM ++ L + +G ++ Q+ Sbjct: 411 TLYHEHIIKYKGCCEDQGE----KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQIC 466 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY-------VVTRWY 191 +G+ Y+H+ IHR+L N+ ++ D +KI DFGLA+ Y WY Sbjct: 467 EGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 526 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APE + + Y D+WS G + E++T + +PP +F++ Sbjct: 527 -APECLKEYKFY-YASDVWSFGVTLYELLTHC----------------DSSQSPPTKFLE 568 Query: 252 RLQSDEAKNYMKGLPE-LEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 + + + + L E LE+ + +L++ +A R T + P Sbjct: 569 LIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI--PI 626 Query: 311 FESLHD 316 +++H+ Sbjct: 627 LKTVHE 632 Score = 92.7 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 40/277 (14%), Positives = 84/277 (30%), Gaps = 55/277 (19%) Query: 44 AVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFT 103 D +V +K L A Y L+ + H ++ + V Sbjct: 88 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP------ 139 Query: 104 DFYLVMPFM-GTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA 160 + +V ++ L ++ E+ + + Q+ L Y+ ++H ++ N+ Sbjct: 140 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 161 VNEDCE-------LKILD--FGLARQADSEMTGYVVTRWYRAPEVILNWMR-YTQTVDIW 210 + +K+ D GL + E + + APE + + +D W Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 256 Query: 211 SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 G + E+ F G +Q E +++ + L + Sbjct: 257 GFGATLLEIC-----FDGEAP------------------LQSRSPSEKEHFYQRQHRLPE 293 Query: 271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + T L + L + QR + L Sbjct: 294 PSCPQLAT--------LTSQCLTYEPTQRPSFRTILR 322 >4GS6-A nrPDB Length = 315 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 114/315 (36%), Gaps = 57/315 (18%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 + VG GA+G VC A VAIK++ +SE K ELR L + H N++ Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSRVNHPNIV 65 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH----EKLGEDRIQFLVYQMLKGLR 142 L LVM + G L ++ Q +G+ Sbjct: 66 KLYGACL--------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 143 YIHAAG---IIHRDLKPGNLAVNEDCEL-KILDFGLARQADSEMTGYVVTRWYRAPEVIL 198 Y+H+ +IHRDLKP NL + + KI DFG A + MT + + APEV Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFE 177 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y++ D++S G I+ E+IT + F G P + + + Sbjct: 178 G-SNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWAVHNGTR 223 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE---ALAHPYFESLH 315 +K LP+ + L+ + D QR + E + H Sbjct: 224 PPLIKNLPKPIES---------------LMTRCWSKDPSQRPSMEEIVKIMTH--LMRYF 266 Query: 316 DTEDEPQVQKYDDSF 330 DEP S Sbjct: 267 PGADEPLQYPCQHSL 281 >2I0E-A nrPDB Length = 353 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 125/316 (39%), Gaps = 55/316 (17%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAKRAYRELRLLKH-MRHE 84 + L +G G++G V + T A+K L + + + E R+L + Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 + L F + L Y VM ++ G DL ++ + E F ++ GL Sbjct: 82 FLTQLHSCFQTMDRL------YFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLF 135 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRWYRAPEVILN 199 ++ + GII+RDLK N+ ++ + +KI DFG+ ++ + T Y APE+I Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA- 194 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + Y ++VD W+ G ++ EM+ G+ F+G D + + IM+ P Sbjct: 195 YQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSM---------- 244 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG-----EALAHPYF--- 311 S AV + + ++ +R+ G + H +F Sbjct: 245 ---------------------SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYI 283 Query: 312 --ESLHDTEDEPQVQK 325 E L E +P + Sbjct: 284 DWEKLERKEIQPPYKP 299 >6DBM-A nrPDB Length = 318 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 38/306 (12%) Query: 24 RAVYRDLQPVGSGAYGAV----CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 + + ++ +G G +G V + TG VA+K L + +E+ +L+ Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KADAGPQHRSGWKQEIDILR 88 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQML 138 + HE++I LVM ++ L + +G ++ Q+ Sbjct: 89 TLYHEHIIKYKGCCEDAGAA----SLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQIC 144 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY-------VVTRWY 191 +G+ Y+H+ IHRDL N+ ++ D +KI DFGLA+ Y WY Sbjct: 145 EGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 204 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APE + + Y D+WS G + E++T + +PP +F++ Sbjct: 205 -APECLKEYKFY-YASDVWSFGVTLYELLTHC----------------DSSQSPPTKFLE 246 Query: 252 RLQSDEAKNYMKGLPE-LEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 + + + + L E LE+ + +L++ +A R T + P Sbjct: 247 LIGIAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLI--PI 304 Query: 311 FESLHD 316 +++H+ Sbjct: 305 LKTVHE 310 >2JD5-A nrPDB Length = 373 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 146/327 (44%), Gaps = 44/327 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 A Y ++ +G G + V A D VA+K + +++ + A E++LL+ + Sbjct: 19 ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDA 75 Query: 85 -----------NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK---HEKLGEDRI 130 +++ LLD F + +V +G +L L+K H + + Sbjct: 76 DNTKEDSMGANHILKLLDHFNHKGP--NGVHVVMVFEVLGENLLALIKKYEHRGIPLIYV 133 Query: 131 QFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAV------NEDCELKILDFGLARQADSEMT 183 + + Q+L GL Y+H GIIH D+KP N+ + ++KI D G A D T Sbjct: 134 KQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYT 193 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD------HLDQLKE 237 + TR YR+PEV+L + DIWS C++ E+ITG LF+ + D + + Sbjct: 194 NSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQ 252 Query: 238 IMKVTGTPPAEFVQRLQSDE----AKNYMKGLPELEKKDFASILTNA-------SPLAVN 286 I+++ G P+ ++ + ++ ++ + +L+ +LT + + Sbjct: 253 IIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISD 312 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFES 313 L ML LD +R AG + HP+ + Sbjct: 313 FLSPMLQLDPRKRADAGGLVNHPWLKD 339 >4AN9-A nrPDB Length = 301 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 122/300 (40%), Gaps = 41/300 (13%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + + +G+G G V +G +A K ++ + + + REL++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-RNQIIRELQVLHECNSP 67 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 ++G F D + + M M G L +++K ++ E + + ++KGL Sbjct: 68 YIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLT 121 Query: 143 YI-HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM-TGYVVTRWYRAPEVILNW 200 Y+ I+HRD+KP N+ VN E+K+ DFG++ Q EM +V TR Y +PE + Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQG- 180 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 Y+ DIWS+G + EM G+ + L I+ PP + + S E Sbjct: 181 THYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN---EPPPKLPSAVFSLE--- 234 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 + + K L+ + +R + + H + + E + Sbjct: 235 -----------------------FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVD 271 >4EBW-A nrPDB Length = 304 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 116/316 (36%), Gaps = 56/316 (17%) Query: 6 PARSGFYRQEVTKTA---WEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKL 58 P Y Q ++ +E+ R + +G G +G V + VAIK Sbjct: 15 PTTENLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTC 74 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLG 117 + S+ ++ +E ++ H +++ L+ V T + +++M +L Sbjct: 75 -KNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENP-------VWIIMELCTLGELR 126 Query: 118 KLMKHEKLGEDRIQF--LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 ++ K D YQ+ L Y+ + +HRD+ N+ V+ + +K+ DFGL+ Sbjct: 127 SFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLS 186 Query: 176 RQADSEM-----TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGS 229 R + G + +W APE I N+ R+T D+W G M E++ G F+G Sbjct: 187 RYMEDSTYYKASKGKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGV 244 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 + D + I P N P +L+ Sbjct: 245 KNNDVIGRIENGERLPMP------------------------------PNCPPTLYSLMT 274 Query: 290 KMLVLDAEQRVTAGEA 305 K D +R E Sbjct: 275 KCWAYDPSRRPRFTEL 290 >6GVJ-A nrPDB Length = 429 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 124/305 (40%), Gaps = 54/305 (17%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR--H 83 +Y L+ +GSG V ++ + AIK + E+ L ++ Sbjct: 145 IYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 203 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLR 142 + +I L D D+ Y+VM DL +K +K + + ML+ + Sbjct: 204 DKIIRLYDYEITDQ------YIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVH 257 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG-----YVVTRWYRAPEVI 197 IH GI+H DLKP N + D LK++DFG+A Q + T V T Y PE I Sbjct: 258 TIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 316 Query: 198 LNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 + + D+WS+GCI+ M GKT F+ + +I Sbjct: 317 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQI--------- 362 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 +L + N+ P++ +KD ++L+ L D +QR++ E LA Sbjct: 363 ---SKLHAIIDPNHEIEFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLA 408 Query: 308 HPYFE 312 HPY + Sbjct: 409 HPYVQ 413 >3C51-A nrPDB Length = 543 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 131/313 (41%), Gaps = 57/313 (18%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA-KRAYRELRLLKHMRHEN 85 + D + +G G +G V + TG A KKL + + + A E ++L + Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM-----KHEKLGEDRIQFLVYQMLK 139 ++ L F + TD LVM M G D+ + + E R F Q++ Sbjct: 247 IVSLAYAF------ETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVS 300 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA---RQADSEMTGYVVTRWYRAPEV 196 GL ++H II+RDLKP N+ +++D ++I D GLA + ++ GY T + APE+ Sbjct: 301 GLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPEL 360 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS----DHLDQLKEIMKVTGTPPAEFVQR 252 +L Y +VD +++G + EMI + F+ ++ + + +++ T P +F Sbjct: 361 LLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKF--- 416 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALA 307 SP + + E +L D E+R+ + Sbjct: 417 ----------------------------SPASKDFCEALLQKDPEKRLGFRDGSCDGLRT 448 Query: 308 HPYFESLHDTEDE 320 HP F + + E Sbjct: 449 HPLFRDISWRQLE 461 >4CRS-A nrPDB Length = 341 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 83/356 (23%), Positives = 140/356 (39%), Gaps = 61/356 (17%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRL---LKHMR 82 +R + G +G V A T AIK L + + E R+ + +R Sbjct: 14 FRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 73 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 H ++ L F E VM + G DL + + E R F ++ GL Sbjct: 74 HPFLVNLFACFQTKE------HVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGL 127 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVIL 198 +Y+H I++RDLK NL ++ + +KI DFGL ++ + + T + APEV+ Sbjct: 128 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL- 186 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 YT+ VD W +G ++ EM+ G++ F G D + I+ P Sbjct: 187 TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL--------- 237 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYFE- 312 S A++++ ++L + E+R+ A + HP+F Sbjct: 238 ----------------------STEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRL 275 Query: 313 ----SLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKE 364 +L D + +P +DV DE+ E PPR+ +S+E Sbjct: 276 IDWSALMDKKVKPPFIPTIRGREDVSNFDDEFT----SEAPILTPPRE-PRILSEE 326 >2VWV-A nrPDB Length = 302 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 123/299 (41%), Gaps = 28/299 (9%) Query: 12 YRQEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRPFQSELF 67 + V + A E+ Y + + +G+G +G VC G K VAIK L + +E Sbjct: 2 PNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTL-KGGYTERQ 60 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 + E ++ H N+I L V T + T+F M D + + Sbjct: 61 RREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEF---MENGALDSFLRLNDGQFTV 117 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 ++ ++ + G+RY+ +HRDL N+ VN + K+ DFGL+R + + Sbjct: 118 IQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTE 177 Query: 188 T--------RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEI 238 T + APE I + ++T D WS G +M E+++ G+ + + D + I Sbjct: 178 TSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAI 236 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 + PP + + + + +KD + P V+ L+KM+ + Sbjct: 237 EQDYRLPPPPDCP-------TSLHQLMLDCWQKDRNARPRF--PQVVSALDKMI-RNPA 285 >4UY9-A nrPDB Length = 323 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 76/338 (22%), Positives = 127/338 (37%), Gaps = 62/338 (18%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA--KRAYRELRLLKHMRHEN 85 + +G G +G V A G +VA+K ++ + +E +L ++H N Sbjct: 12 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 69 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 +I L V + + LVM F G L +++ +++ D + Q+ +G+ Y+ Sbjct: 70 IIALRGVCLKEP------NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 123 Query: 145 HAAGI---IHRDLKPGNLAVN--------EDCELKILDFGLARQADSEMT-GYVVTRWYR 192 H I IHRDLK N+ + + LKI DFGLAR+ T + Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWM 183 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 APEVI M +++ D+WS G ++ E++TG+ F+G D L + P Sbjct: 184 APEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP------ 236 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 I + L+E D R + L + Sbjct: 237 -----------------------IPSTCPEPFAKLMEDCWNPDPHSRPSFTNIL-----D 268 Query: 313 SLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS 350 L E + ++ D D WK +E+ Sbjct: 269 QLTTIE---ESGFFEMPKDSFHCLQDNWKHEI-QEMFD 302 >4OTD-A nrPDB Length = 341 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 78/349 (22%), Positives = 134/349 (38%), Gaps = 60/349 (17%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHM-- 81 ++ L +G G +G V + +G AIK L + + E R+L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 82 -RHENVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKHEKLGEDRIQFLVYQMLK 139 H ++ L F E VM + G DL + + E R F ++ Sbjct: 72 AGHPFLVNLFGCFQTPE------HVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVL 125 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEV 196 GL+++H I++RDLK NL ++ + +KI DFGL ++ + + T + APEV Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + + YT+ VD W +G ++ EM+ G++ F G D + I+ P Sbjct: 186 LTD-TSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL------- 237 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYF 311 S A+ ++ ++L + E+R+ A + P+F Sbjct: 238 ------------------------SAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 273 Query: 312 -----ESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPR 355 E+L P DV +E+ E + PPR Sbjct: 274 RTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFT----GEAPTLSPPR 318 >1JPA-A nrPDB Length = 312 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 67/302 (22%), Positives = 123/302 (40%), Gaps = 34/302 (11%) Query: 12 YRQEVTKTAWEVRAVYRDLQ-PVGSGAYGAVCSAVDGRTGAK---VAIKKLYRPFQSELF 67 + V + A E+ ++ +G+G +G VCS G + VAIK L + +E Sbjct: 19 PNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY-TEKQ 77 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--K 124 + E ++ H NVI L V T T ++ FM L ++ + Sbjct: 78 RRDFLSEASIMGQFDHPNVIHLEGVVTKS------TPVMIITEFMENGSLDSFLRQNDGQ 131 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG 184 ++ ++ + G++Y+ +HRDL N+ VN + K+ DFGL+R + + + Sbjct: 132 FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSD 191 Query: 185 YVVT--------RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQL 235 T + APE I + ++T D+WS G +M E+++ G+ + + D + Sbjct: 192 PTYTSALGGKIPIRWTAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVI 250 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 I + PP + + + +KD VN L+KM+ + Sbjct: 251 NAIEQDYRLPPPMDCP-------SALHQLMLDCWQKDRNHRPKFG--QIVNTLDKMI-RN 300 Query: 296 AE 297 Sbjct: 301 PN 302 >1ZXE-A nrPDB Length = 303 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 124/320 (38%), Gaps = 61/320 (19%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + ++ +G GA+G V A + AIKK+ +E E+ LL + H+ V Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRH---TEEKLSTILSEVMLLASLNHQYV 64 Query: 87 IGLLDVFTPDETL-------DDFTDFYLVMPFMGT-DLGKLMKHEKLGE--DRIQFLVYQ 136 + + + ++ M + L L+ E L + D L Q Sbjct: 65 VRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQ 124 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD----------------- 179 +L+ L YIH+ GIIHR+LKP N+ ++E +KI DFGLA+ Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK-GSDHLDQLKEI 238 +T + T Y A EV+ Y + +D++S+G I EMI F G + ++ LK++ Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTGMERVNILKKL 241 Query: 239 MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQ 298 V+ P +F E K ++ ++ D + Sbjct: 242 RSVSIEFPPDFDDNKMKVEKK---------------------------IIRLLIDHDPNK 274 Query: 299 RVTAGEALAHPYFESLHDTE 318 R A L + H E Sbjct: 275 RPGARTLLNSGWLPVKHQDE 294 >1K9A-A nrPDB Length = 450 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 124/316 (39%), Gaps = 54/316 (17%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 M A+ FYR E+ + LQ +G G +G V G KVA+K + Sbjct: 173 MEGTVAAQDEFYRSGWALNMKEL----KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK- 225 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGK 118 ++ A+ E ++ +RH N++ LL V +++ Y+V +M G+ + Sbjct: 226 ---NDATAQAFLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDY 277 Query: 119 LMKHEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR 176 L + LG D + + + + Y+ +HRDL N+ V+ED K+ DFGL + Sbjct: 278 LRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 337 Query: 177 QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQL 235 +A S + + APE + +++ D+WS G ++ E+ + G+ + D Sbjct: 338 EASSTQDTGKLPVKWTAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV- 395 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 +P +EK P ++++ LD Sbjct: 396 -----------------------------VPRVEKGYKMDAPDGCPPAVYDVMKNCWHLD 426 Query: 296 AEQRVTAGEA---LAH 308 A R T + L H Sbjct: 427 AATRPTFLQLREQLEH 442 >2R2P-A nrPDB Length = 295 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 127/306 (41%), Gaps = 32/306 (10%) Query: 6 PARSGFYRQEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRP 61 P Q V + A E+ A + +G+G +G VCS G + VAIK L Sbjct: 2 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM 120 + +E + E ++ H N+I L V T + +V +M L + Sbjct: 62 Y-TEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKP------VMIVTEYMENGSLDTFL 114 Query: 121 KHE--KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 K + ++ ++ + G++Y+ G +HRDL N+ +N + K+ DFGL+R Sbjct: 115 KKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVL 174 Query: 179 DSEMTGYVVTRW------YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 + + TR + APE I + ++T D+WS G +M E+++ G+ + + Sbjct: 175 EDDPEAAYTTRGGKIPIRWTAPEAIA-FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTN 233 Query: 232 LDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKM 291 D +K + + P + + + +K+ S VN+L+K Sbjct: 234 QDVIKAVEEGYRLPSPMDCPA-------ALYQLMLDCWQKERNSRPKF--DEIVNMLDK- 283 Query: 292 LVLDAE 297 L+ + Sbjct: 284 LIRNPA 289 >4P5Q-A nrPDB Length = 361 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 126/297 (42%), Gaps = 32/297 (10%) Query: 14 QEVTKTAWEVRAV-YRDLQPVGSGAYGAVCSAVDG---RTGAKVAIKKLYRPFQSELFAK 69 Q V + A E+ A + VG+G +G VCS + VAIK L + +E + Sbjct: 21 QTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGY-TEKQRR 79 Query: 70 RAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLG 126 E ++ H N+I L V T + +V +M L ++ + Sbjct: 80 DFLGEASIMGQFDHPNIIRLEGVVTKSKP------VMIVTEYMENGSLDSFLRKHDAQFT 133 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV 186 ++ ++ + G++Y+ G +HRDL N+ +N + K+ DFGL+R + + Sbjct: 134 VIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 193 Query: 187 VTRW------YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIM 239 TR + +PE I + ++T D+WS G ++ E+++ G+ + + D +K + Sbjct: 194 TTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVD 252 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 + PP + + + +KD + V++L+K L+ + Sbjct: 253 EGYRLPPPMDCPA-------ALYQLMLDCWQKDRNNRPKF--EQIVSILDK-LIRNP 299 >5VO2-A nrPDB Length = 300 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 135/332 (40%), Gaps = 54/332 (16%) Query: 17 TKTAWEVR-AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 ++ WEV DLQ VGSGA GAV G +VA+KK+ +++ + Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------I 51 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK-LGEDRIQFL 133 + L+ ++H N+I V T + ++M F L ++++ + + + Sbjct: 52 KHLRKLKHPNIITFKGVCTQAP------CYCILMEFCAQGQLYEVLRAGRPVTPSLLVDW 105 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT--GYVVTRWY 191 + G+ Y+H IIHRDLK N+ + D +KI DFG +++ + T + T + Sbjct: 106 SMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAW 165 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APEVI N ++ VDIWS G ++ E++TG+ +K D + + + P Sbjct: 166 MAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP----- 219 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + ++ LL + R + + L H Sbjct: 220 ------------------------VPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI 255 Query: 312 ES--LHDTEDEPQVQKYDDSFDDVDRTLDEWK 341 S + T E + + ++V ++ K Sbjct: 256 ASADVLSTPQETYFKSQAEWREEVKLHFEKIK 287 >1BYG-A nrPDB Length = 278 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 123/316 (38%), Gaps = 54/316 (17%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 M A+ FYR E+ + LQ +G G +G V G KVA+K + Sbjct: 1 MGGSVAAQDEFYRSGWALNMKEL----KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK- 53 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGK 118 ++ A+ E ++ +RH N++ LL V +++ Y+V +M G+ + Sbjct: 54 ---NDATAQAFLAEASVMTQLRHSNLVQLLGVI-----VEEKGGLYIVTEYMAKGSLVDY 105 Query: 119 LMKHEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR 176 L + LG D + + + + Y+ +HRDL N+ V+ED K+ DFGL + Sbjct: 106 LRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK 165 Query: 177 QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQL 235 +A S + + APE + +++ D+WS G ++ E+ + G+ + D Sbjct: 166 EASSTQDTGKLPVKWTAPEAL-REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV- 223 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 +P +EK P +++ LD Sbjct: 224 -----------------------------VPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 254 Query: 296 AEQRVTAGEA---LAH 308 A R + + L H Sbjct: 255 AAMRPSFLQLREQLEH 270 >4KIK-B nrPDB Length = 677 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 126/295 (42%), Gaps = 25/295 (8%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 T AWE++ + +G+G +G V + TG ++AIK+ + S +R E++ Sbjct: 17 TCGAWEMK------ERLGTGGFGNVIRWHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQ 69 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH----EKLGEDRIQ 131 +++ + H NV+ DV + L L M + G DL K + L E I Sbjct: 70 IMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAIL 129 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQAD--SEMTGYV 186 L+ + LRY+H IIHRDLKP N+ + + KI+D G A++ D S T +V Sbjct: 130 TLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFV 189 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 T Y APE +L +YT TVD WS G + E ITG F + Q ++ Sbjct: 190 GTLQYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVD 248 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 + L + P A L L+ ML+ QR T Sbjct: 249 IVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW-------LQLMLMWHPRQRGT 296 >4E93-A nrPDB Length = 377 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 112/299 (37%), Gaps = 48/299 (16%) Query: 13 RQEVTKTAWEVR-AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 + V K W + + +G G +G V S VA+K +L AK Sbjct: 101 HRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-F 159 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGED 128 +E R+LK H N++ L+ V T + + Y+VM + G D ++ E +L Sbjct: 160 LQEARILKQYSHPNIVRLIGVCTQKQPI------YIVMELVQGGDFLTFLRTEGARLRVK 213 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVT 188 + +V G+ Y+ + IHRDL N V E LKI DFG++R+ + Sbjct: 214 TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG 273 Query: 189 RW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVT 242 + APE + N+ RY+ D+WS G ++ E + G + + + + + K Sbjct: 274 LRQVPVKWTAPEAL-NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG 332 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 P E L+E+ + QR + Sbjct: 333 RLPCPELCPDAVFR------------------------------LMEQCWAYEPGQRPS 361 >5AP3-A nrPDB Length = 313 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 129/329 (39%), Gaps = 58/329 (17%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q ++ +Y L+ +GSG V ++ + AIK + Sbjct: 9 SGVDLGTENLYFQSMSVKG----RIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLE 63 Query: 62 FQSELFAKRAYRELRLLKHMR--HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL 119 E+ L ++ + +I L D D+ Y+VM DL Sbjct: 64 EADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQ------YIYMVMECGNIDLNGW 117 Query: 120 MKHEK-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 +K +K + + ML+ + IH GI+H DLKP N + D LK++DFG+A Q Sbjct: 118 LKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQM 176 Query: 179 DSEMTG-----YVVTRWYRAPEVILNWMRYTQT----------VDIWSVGCIMAEMITGK 223 + T V T Y PE I + + D+WS+GCI+ M GK Sbjct: 177 QPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGK 236 Query: 224 TLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL 283 T F+ + +I +L + N+ P++ +KD Sbjct: 237 TPFQ-----QIINQI------------SKLHAIIDPNHEIEFPDIPEKDLQ--------- 270 Query: 284 AVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 ++L+ L D +QR++ E LAHPY + Sbjct: 271 --DVLKCCLKRDPKQRISIPELLAHPYVQ 297 >1TKI-A nrPDB Length = 321 Score = 204 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 127/299 (42%), Gaps = 44/299 (14%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 E+ Y + +G G +G V V+ + K + ++ K+ E+ +L Sbjct: 2 ELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKK---EISILNIA 58 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQFLVYQML 138 RH N++ L + F E + ++ F+ G D+ + + +L E I V+Q+ Sbjct: 59 RHRNILHLHESFESME------ELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVC 112 Query: 139 KGLRYIHAAGIIHRDLKPGNLA--VNEDCELKILDFGLARQADSEMTGYV--VTRWYRAP 194 + L+++H+ I H D++P N+ +KI++FG ARQ + Y AP Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAP 172 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 EV + + + D+WS+G ++ +++G F + ++ IM T E Sbjct: 173 EVHQHDVV-STATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEE------ 225 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 S A++ ++++LV + + R+TA EAL HP+ + Sbjct: 226 ---------------------AFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >3DTC-A nrPDB Length = 271 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 121/279 (43%), Gaps = 35/279 (12%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA--KRAYRELRLLKHMRHEN 85 + +G G +G V A G +VA+K ++ + +E +L ++H N Sbjct: 10 TLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPN 67 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 +I L V + + LVM F G L +++ +++ D + Q+ +G+ Y+ Sbjct: 68 IIALRGVCLKEP------NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 121 Query: 145 HAAGI---IHRDLKPGNLAVN--------EDCELKILDFGLARQADSEMT-GYVVTRWYR 192 H I IHRDLK N+ + + LKI DFGLAR+ + Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM 181 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 APEVI M +++ D+WS G ++ E++TG+ F+G D L + P Sbjct: 182 APEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP------ 234 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKM 291 + S + + K + + D ++ P N+L+++ Sbjct: 235 IPSTCPEPFAKLMEDCWNPD-----PHSRPSFTNILDQL 268 >4YHJ-A nrPDB Length = 584 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 79/322 (24%), Positives = 133/322 (41%), Gaps = 52/322 (16%) Query: 11 FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70 RQ VTK +R + +G G +G VC+ TG A KKL + + + Sbjct: 177 LERQPVTKNT------FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEA 230 Query: 71 -AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG---KLMKHEKL 125 A E R+L+ ++ V+ L + + L LV+ M G DL + + Sbjct: 231 MALNEKRILEKVQSRFVVSLAYAYETKDAL------CLVLTIMNGGDLKFHIYNLGNPGF 284 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS--EMT 183 E R F ++ GL + I++RDLKP N+ +++ ++I D GLA + + Sbjct: 285 DEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVR 344 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 G V T Y APEV+ N +YT + D W +GC++ EMI G + FK + +E+ + Sbjct: 345 GRVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIK 403 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV--- 300 E+ ++ S A ++ +L + +R+ Sbjct: 404 NDTEEYSEKF---------------------------SEDAKSICRMLLTKNPSKRLGCR 436 Query: 301 --TAGEALAHPYFESLHDTEDE 320 A HP F+ ++ E Sbjct: 437 GEGAAGVKQHPVFKDINFRRLE 458 >5O2B-A nrPDB Length = 285 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 38/286 (13%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G GA+ V +D T +VA +L ++ +R E +LK ++H N++ D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 92 VFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG- 148 + + L LV M GT L + + + ++ Q+LKGL+++H Sbjct: 83 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 149 -IIHRDLKPGNLAVN-EDCELKILDFGLARQA-DSEMTGYVVTRWYRAPEVILNWMRYTQ 205 IIHRDLK N+ + +KI D GLA S + T + APE+ Y + Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYE--EHYDE 198 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 +VD+++ G M EM T + + + Q+ + +G PA F + Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV-TSGIKPASFNKV------------- 244 Query: 266 PELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 P ++E + + +R++ + L H +F Sbjct: 245 --------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 276 >1AD5-A nrPDB Length = 438 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 124/288 (43%), Gaps = 31/288 (10%) Query: 4 PPPARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 P S ++ K AWE+ R + + +G+G +G V A + KVA+K + Sbjct: 160 SVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMK--- 215 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK 121 + + E ++K ++H+ ++ L V T + Y++ FM L +K Sbjct: 216 PGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP-------IYIITEFMAKGSLLDFLK 268 Query: 122 HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 + K ++ Q+ +G+ +I IHRDL+ N+ V+ KI DFGLAR Sbjct: 269 SDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR-- 326 Query: 179 DSEMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQ 234 V ++ + APE I N+ +T D+WS G ++ E++T G+ + G + + Sbjct: 327 -------VGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEV 378 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP 282 ++ + + P E + K PE E+ F I + Sbjct: 379 IRALERGYRMPRPENCPEELYNIMMRCWKNRPE-ERPTFEYIQSVLDD 425 >3A4O-X nrPDB Length = 286 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 73/266 (27%), Positives = 120/266 (45%), Gaps = 21/266 (7%) Query: 15 EVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR 73 K AWE+ R + ++ +G+G +G V + KVA+K L S + Sbjct: 2 PWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS---VQAFLE 57 Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDR 129 E L+K ++H+ ++ L V T +E + Y++ +M L +K K+ + Sbjct: 58 EANLMKTLQHDKLVRLYAVVTREEPI------YIITEYMAKGSLLDFLKSDEGGKVLLPK 111 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVT 188 + Q+ +G+ YI IHRDL+ N+ V+E KI DFGLAR D+E T Sbjct: 112 LIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGA 171 Query: 189 RW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGT 244 ++ + APE I N+ +T D+WS G ++ E++T GK + G + D + + + Sbjct: 172 KFPIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM 230 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEK 270 P E D K K E Sbjct: 231 PRVENCPDELYDIMKMCWKEKAEERP 256 >3HMP-A nrPDB Length = 342 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 124/305 (40%), Gaps = 54/305 (17%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR--H 83 +Y L+ +GSG V ++ + AIK + E+ L ++ Sbjct: 57 IYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLR 142 + +I L D D+ Y+VM DL +K +K + + ML+ + Sbjct: 116 DKIIRLYDYEITDQ------YIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVH 169 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG-----YVVTRWYRAPEVI 197 IH GI+H DLKP N + D LK++DFG+A Q + T V T Y PE I Sbjct: 170 TIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 228 Query: 198 LNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 + + D+WS+GCI+ M GKT F+ + +I Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQI--------- 274 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 +L + N+ P++ +KD ++L+ L D +QR++ E LA Sbjct: 275 ---SKLHAIIDPNHEIEFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLA 320 Query: 308 HPYFE 312 HPY + Sbjct: 321 HPYVQ 325 >4WUA-A nrPDB Length = 401 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 87/378 (23%), Positives = 145/378 (38%), Gaps = 84/378 (22%) Query: 14 QEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR 73 + K Y ++ +G G + V + D + VA+K + +E + + A Sbjct: 30 YHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALD 86 Query: 74 ELRLLKHMRH--EN------VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM---KH 122 E+RLLK +R+ N V+ LLD F + T +V +G L K + + Sbjct: 87 EIRLLKSVRNSDPNDPNREMVVQLLDDFKISGV--NGTHICMVFEVLGHHLLKWIIKSNY 144 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVN------------------- 162 + L ++ ++ Q+L+GL Y+H IIH D+KP N+ ++ Sbjct: 145 QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRS 204 Query: 163 ------------------------------EDCELKILDFGLARQADSEMTGYVVTRWYR 192 E ++KI D G A T + TR YR Sbjct: 205 GAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYR 264 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD------HLDQLKEIMKVTGTPP 246 + EV++ Y DIWS C+ E+ TG LF+ D + I+++ G P Sbjct: 265 SLEVLIG-SGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVP 323 Query: 247 AEFVQRLQSDE----AKNYMKGLPELEKKDFASILTNASPL-------AVNLLEKMLVLD 295 + + + + K +K + +L+ +L + L ML L Sbjct: 324 RKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELI 383 Query: 296 AEQRVTAGEALAHPYFES 313 E+R TA E L HP+ S Sbjct: 384 PEKRATAAECLRHPWLNS 401 >4UYA-A nrPDB Length = 340 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 127/332 (38%), Gaps = 61/332 (18%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE--LFAKRAYRELRLLKHMR 82 + +G+G +G V A G +VA+K + + + A+ RE RL +R Sbjct: 26 ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLR 83 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 H N+I L V LV+ F G L + + ++ + Q+ +G+ Sbjct: 84 HPNIIELRGVCLQQP------HLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGM 137 Query: 142 RYIHAAG---IIHRDLKPGNLAVNE--------DCELKILDFGLARQADSEMT-GYVVTR 189 Y+H I+HRDLK N+ + E + LKI DFGLAR+ Sbjct: 138 LYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAY 197 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 + APEVI + + +++ DIWS G ++ E++TG+ ++G D L + T P Sbjct: 198 AWMAPEVIKSSL-FSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP--- 253 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 I + L+++ D R + L Sbjct: 254 --------------------------IPSTCPEPFAKLMKECWQQDPHIRPSFALIL--- 284 Query: 310 YFESLHDTEDEPQVQKYDDSFDDVDRTLDEWK 341 E L E + +SF + D+WK Sbjct: 285 --EQLTAIEGAVMTEMPQESFHSMQ---DDWK 311 >5UUU-A nrPDB Length = 547 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 123/300 (41%), Gaps = 46/300 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-AYRELRLLKHM---R 82 + + +G G +G V TG A+K L + + A E +L + Sbjct: 200 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 259 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQMLKG 140 ++ + F + L ++ M G DL L +H E ++F +++ G Sbjct: 260 CPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM-TGYVVTRWYRAPEVILN 199 L ++H +++RDLKP N+ ++E ++I D GLA + V T Y APEV+ Sbjct: 314 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 373 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + Y + D +S+GC++ +++ G + F+ D+ EI ++T T E Sbjct: 374 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF------ 426 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYFESL 314 SP +LLE +L D +R+ A E P+F SL Sbjct: 427 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 465 >2X7G-A nrPDB Length = 389 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 79/366 (21%), Positives = 141/366 (38%), Gaps = 82/366 (22%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR- 82 Y ++ +G G + V D + VA+K + ++ + + A E++LLK +R Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRE 86 Query: 83 ----HEN---VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM---KHEKLGEDRIQF 132 N V+ L+D F + +V +G L K + ++ L ++ Sbjct: 87 SDPSDPNKDMVVQLIDDFKISGM--NGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKS 144 Query: 133 LVYQMLKGLRYIHAA-GIIHRDLKPGNLAV------------------------------ 161 ++ Q+L+GL Y+H+ IIH D+KP N+ + Sbjct: 145 IIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAV 204 Query: 162 -----------------NEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT 204 + +KI D G A T + TR YR+ EV++ Y+ Sbjct: 205 STAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG-AGYS 263 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSD------HLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 DIWS C+ E+ TG LF+ D + I+++ G+ P F + Sbjct: 264 TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSRE 323 Query: 259 ----KNYMKGLPELEKKDFASILTNA-------SPLAVNLLEKMLVLDAEQRVTAGEALA 307 + ++ + +L+ +L + + L ML + E+R +AGE L Sbjct: 324 FFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLR 383 Query: 308 HPYFES 313 HP+ S Sbjct: 384 HPWLNS 389 >4EQM-A nrPDB Length = 294 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 120/272 (44%), Gaps = 17/272 (6%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHM 81 + Y+ + +G G V A D KVAIK ++ P + E KR RE+ + Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQL 68 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT--DLGKLMKHEKLGEDRIQFLVYQMLK 139 H+N++ ++DV D+ +YLVM ++ + H L D Q+L Sbjct: 69 SHQNIVSMIDVDEEDD------CYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWYRAPE 195 G+++ H I+HRD+KP N+ ++ + LKI DFG+A+ + + T Y +PE Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPE 182 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 + DI+S+G ++ EM+ G+ F G + I + + P ++ Sbjct: 183 QAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSI--AIKHIQDSVPN-VTTDVRK 238 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNL 287 D ++ + +KD A+ + +L Sbjct: 239 DIPQSLSNVILRATEKDKANRYKTIQEMKDDL 270 >5O2C-A nrPDB Length = 380 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 38/286 (13%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G GA+ V +D T +VA +L ++ +R E +LK ++H N++ D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 92 VFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG- 148 + + L LV M GT L + + + ++ Q+LKGL+++H Sbjct: 92 SW--ESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 149 -IIHRDLKPGNLAVN-EDCELKILDFGLARQA-DSEMTGYVVTRWYRAPEVILNWMRYTQ 205 IIHRDLK N+ + +KI D GLA S + T + APE+ Y + Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYE--EHYDE 207 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 +VD+++ G M EM T + + + Q+ + +G PA F + Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV-TSGIKPASFNKV------------- 253 Query: 266 PELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 P ++E + + +R++ + L H +F Sbjct: 254 --------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFF 285 >3PVW-A nrPDB Length = 695 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 123/300 (41%), Gaps = 46/300 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-AYRELRLLKHM---R 82 + + +G G +G V TG A+K L + + A E +L + Sbjct: 191 FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGD 250 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG-KLMKHEKLGEDRIQFLVYQMLKG 140 ++ + F + L ++ M G DL L +H E ++F +++ G Sbjct: 251 CPFIVCMSYAFHTPDKLS------FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM-TGYVVTRWYRAPEVILN 199 L ++H +++RDLKP N+ ++E ++I D GLA + V T Y APEV+ Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQK 364 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 + Y + D +S+GC++ +++ G + F+ D+ EI ++T T E Sbjct: 365 GVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVELPDSF------ 417 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPYFESL 314 SP +LLE +L D +R+ A E P+F SL Sbjct: 418 ---------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 >2J0K-A nrPDB Length = 656 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 63/311 (20%), Positives = 110/311 (35%), Gaps = 52/311 (16%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAV---DGRTGAKVAIKKLYRPFQ 63 Y T+ R + +G G +G V + VAIK + Sbjct: 372 DEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTC-KNCT 430 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKH 122 S+ ++ +E ++ H +++ L+ V T + +++M +L ++ Sbjct: 431 SDSVREKFLQEALTMRQFDHPHIVKLIGVITENP-------VWIIMELCTLGELRSFLQV 483 Query: 123 EKLGEDRIQF--LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 K D YQ+ L Y+ + +HRD+ N+ V+ +K+ DFGL+R + Sbjct: 484 RKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMED 543 Query: 181 EM-----TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQ 234 G + +W APE I N+ R+T D+W G M E++ G F+G + D Sbjct: 544 STYYKASKGKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 601 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 + I P N P +L+ K Sbjct: 602 IGRIENGERLPMP------------------------------PNCPPTLYSLMTKCWAY 631 Query: 295 DAEQRVTAGEA 305 D +R E Sbjct: 632 DPSRRPRFTEL 642 >4PWN-A nrPDB Length = 274 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 121/289 (41%), Gaps = 39/289 (13%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLD 91 +G G++ V +D T +VA +L ++ +R E +LK ++H N++ D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 92 VFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG- 148 + + T+ LV M GT L + + + ++ Q+LKGL+++H Sbjct: 77 SW--ESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTP 134 Query: 149 -IIHRDLKPGNLAVN-EDCELKILDFGLARQAD--SEMTGYVVTRWYRAPEVILNWMRYT 204 IIHRDLK N+ + +KI D GLA S + T + APE+ +Y Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYE--EKYD 192 Query: 205 QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKG 264 ++VD+++ G M EM T + + + Q+ + +G PA F + Sbjct: 193 ESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRV-TSGVKPASFDKVAI---------- 241 Query: 265 LPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 P ++E + + ++R + + L H +F+ Sbjct: 242 -----------------PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >6BXI-A nrPDB Length = 333 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 85/363 (23%), Positives = 128/363 (35%), Gaps = 86/363 (23%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKHMRH 83 + L+ +G GA+G V TG A+K L + E R E +L Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM-KHEKLGEDRIQFLVYQMLKGL 141 V+ + F D + YL+M F+ G D+ L+ K + L E+ QF + + + + Sbjct: 66 LWVVKMFYSF------QDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG----------------- 184 IH G IHRD+KP NL ++ +K+ DFGL Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ 179 Query: 185 ---------------------YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 V T Y APEV + Y + D WS+G IM EM+ G Sbjct: 180 NMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM-QTGYNKLCDWWSLGVIMYEMLIGY 238 Query: 224 TLFKGSDHLDQLKEIM--KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 F + K++M K T T P E S Sbjct: 239 PPFCSETPQETYKKVMNWKETLTFPPEVP-----------------------------IS 269 Query: 282 PLAVNLLEKMLVLDAEQRVTA---GEALAHPYFESL---HDTEDEPQVQKYDDSFDDVDR 335 A +L+ + + E R+ A E ++ +FE + H E + S DD Sbjct: 270 EKAKDLILR-FCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSN 328 Query: 336 TLD 338 + Sbjct: 329 FDE 331 >4AT3-A nrPDB Length = 299 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 122/296 (41%), Gaps = 40/296 (13%) Query: 24 RAVYRDLQPVGSGAYGAVCSAV-----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 R + +G GA+G V A + VA+K L S+ K +RE LL Sbjct: 12 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA--SDNARKDFHREAELL 69 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-------------- 123 +++HE+++ V + L +V +M DL K ++ Sbjct: 70 TNLQHEHIVKFYGVCVEGDPL------IMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT 123 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 +L + ++ + Q+ G+ Y+ + +HRDL N V E+ +KI DFG++R S Sbjct: 124 ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDY 183 Query: 184 GYVV-----TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKE 237 V + PE I+ + ++T D+WS+G ++ E+ T GK + + + ++ Sbjct: 184 YRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 242 Query: 238 I-----MKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLL 288 I ++ T P E + + + L ASP+ +++L Sbjct: 243 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >2W1I-A nrPDB Length = 326 Score = 200 bits (509), Expect = 9e-52, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 137/323 (42%), Gaps = 47/323 (14%) Query: 6 PARSGFYRQEVTKTAWEVRA-------VYRDLQPVGSGAYGAVCSAV----DGRTGAKVA 54 P Y Q +A+E R + LQ +G G +G+V TG VA Sbjct: 15 PTTENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA 74 Query: 55 IKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-- 112 +KKL +E + RE+ +LK ++H+N++ V + L+M ++ Sbjct: 75 VKKLQH--STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGR----RNLKLIMEYLPY 128 Query: 113 GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILD 171 G+ L KH E++ ++ Q+ KG+ Y+ IHRDL N+ V + +KI D Sbjct: 129 GSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGD 188 Query: 172 FGLARQADSEMTGY-------VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT 224 FGL + + Y WY APE + +++ D+WS G ++ E+ T Sbjct: 189 FGLTKVLPQDKEYYKVKEPGESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFT--- 243 Query: 225 LFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE-AKNYMKGLPELEKKDFASILTNASPL 283 ++ + +PPAEF++ + +D+ + + L EL K + + P Sbjct: 244 -------------YIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPD 290 Query: 284 AVNLL-EKMLVLDAEQRVTAGEA 305 + ++ + + QR + + Sbjct: 291 EIYMIMTECWNNNVNQRPSFRDL 313 >2HK5-A nrPDB Length = 270 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 125/280 (44%), Gaps = 23/280 (8%) Query: 13 RQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 ++ K AWE+ R + + +G+G +G V A + KVA+K + + + Sbjct: 2 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMK---PGSMSVEAF 57 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE---KLGE 127 E ++K ++H+ ++ L V T + Y++ FM L +K + K Sbjct: 58 LAEANVMKTLQHDKLVKLHAVVTKEP-------IYIITEFMAKGSLLDFLKSDEGSKQPL 110 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYV 186 ++ Q+ +G+ +I IHRDL+ N+ V+ KI DFGLAR D+E T Sbjct: 111 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTARE 170 Query: 187 VTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVT 242 ++ + APE I N+ +T D+WS G ++ E++T G+ + G + + ++ + + Sbjct: 171 GAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY 229 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP 282 P E + K PE E+ F I + Sbjct: 230 RMPRPENCPEELYNIMMRCWKNRPE-ERPTFEYIQSVLDD 268 >2ZMD-A nrPDB Length = 390 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 123/305 (40%), Gaps = 54/305 (17%) Query: 26 VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR--H 83 +Y L+ +GSG V ++ + AIK + E+ L ++ Sbjct: 57 IYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRIQFLVYQMLKGLR 142 + +I L D D+ Y+VM DL +K +K + + ML+ + Sbjct: 116 DKIIRLYDYEITDQ------YIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVH 169 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG-----YVVTRWYRAPEVI 197 IH GI+H DLKP N + D LK++DFG+A Q + T V Y PE I Sbjct: 170 TIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI 228 Query: 198 LNWMRYTQT----------VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 + + D+WS+GCI+ M GKT F+ + +I Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQI--------- 274 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 +L + N+ P++ +KD ++L+ L D +QR++ E LA Sbjct: 275 ---SKLHAIIDPNHEIEFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLA 320 Query: 308 HPYFE 312 HPY + Sbjct: 321 HPYVQ 325 >3V5Q-A nrPDB Length = 297 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 63/325 (19%), Positives = 117/325 (36%), Gaps = 69/325 (21%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAV-----DGRTGAKVAIKKLYRPFQS 64 G + + R + + +G GA+G V A + VA+K L P + Sbjct: 1 GAMHSGIHVQHIKRRDI-VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA 59 Query: 65 ELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK-- 121 K RE LL +++HE+++ V + L +V +M DL K ++ Sbjct: 60 --ARKDFQREAELLTNLQHEHIVKFYGVCGDGDPL------IMVFEYMKHGDLNKFLRAH 111 Query: 122 ---------------HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE 166 +LG ++ + Q+ G+ Y+ + +HRDL N V + Sbjct: 112 GPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL 171 Query: 167 LKILDFGLARQADSEMTGYVV-----TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 +KI DFG++R S V + PE I+ + ++T D+WS G I+ E+ T Sbjct: 172 VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFT 230 Query: 222 -GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA 280 GK + + + ++ I + + Sbjct: 231 YGKQPWFQLSNTEVIECITQGRVLERPRVCPK---------------------------- 262 Query: 281 SPLAVNLLEKMLVLDAEQRVTAGEA 305 +++ + +QR+ E Sbjct: 263 --EVYDVMLGCWQREPQQRLNIKEI 285 >2PL0-A nrPDB Length = 289 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 122/273 (44%), Gaps = 22/273 (8%) Query: 8 RSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 ++ ++ + WEV R + ++ +G+G +G V KVA+K L Q + Sbjct: 5 QTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLK---QGSM 60 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-- 123 E L+K ++H+ ++ L V T + Y++ +M L +K Sbjct: 61 SPDAFLAEANLMKQLQHQRLVRLYAVVTQEP-------IYIITEYMENGSLVDFLKTPSG 113 Query: 124 -KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSE 181 KL +++ + Q+ +G+ +I IHRDL+ N+ V++ KI DFGLAR D+E Sbjct: 114 IKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNE 173 Query: 182 MTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKE 237 T ++ + APE I N+ +T D+WS G ++ E++T G+ + G + + ++ Sbjct: 174 YTAREGAKFPIKWTAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQN 232 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 + + + + K PE Sbjct: 233 LERGYRMVRPDNCPEELYQLMRLCWKERPEDRP 265 >5H2U-A nrPDB Length = 267 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 116/292 (39%), Gaps = 49/292 (16%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R + + +GSG +G V + +VAIK + R L + E++ +K +RH Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNL--LHQQMLQSEIQAMKKLRH 61 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK---HEKLGEDRIQFLVYQMLK 139 ++++ L V + + Y++ M L +L++ + L + + +Q+ + Sbjct: 62 KHILALYAVVSVGDP------VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAE 115 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRW-YRAPEV 196 G+ Y+ + IHRDL N+ V E+ K+ DFGLAR + ++ + + APE Sbjct: 116 GMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEA 175 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 + + Y+ D+WS G ++ EM + G+ + G + + + P Sbjct: 176 L-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPL------- 227 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 P L+ D EQR T AL Sbjct: 228 -----------------------ECPPSVHKLMLTCWCRDPEQRPTFK-ALR 255 >1S9I-A nrPDB Length = 354 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 125/310 (40%), Gaps = 31/310 (10%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + + +G+G G V +G +A K ++ + + + REL++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAI-RNQIIRELQVLHECNSP 74 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLR 142 ++G F D + + M M G L +++K +++ E+ + + +L+GL Sbjct: 75 YIVGFYGAFYSDG------EISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLA 128 Query: 143 YI-HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVTRWYRAPEVILNW 200 Y+ I+HRD+KP N+ VN E+K+ DFG++ Q DS +V TR Y APE + Sbjct: 129 YLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG- 187 Query: 201 MRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE------------ 248 Y+ DIWS+G + E+ G+ D + L+ I E Sbjct: 188 THYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 249 -----FVQRLQSDEAKNYMKGLPELEKKDFASILTNA-SPLAVNLLEKMLVLDAEQRVTA 302 + S A + L + + + +P + K L+ + +R Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 306 Query: 303 GEALAHPYFE 312 H + + Sbjct: 307 KMLTNHTFIK 316 >4E20-A nrPDB Length = 290 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 113/295 (38%), Gaps = 36/295 (12%) Query: 24 RAVYRDLQPVGSGAYGAV----CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 + + ++ +G G +G V + TG VA+K L + RE+ +L+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KEGCGPQLRSGWQREIEILR 65 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQML 138 + HE+++ LVM ++ L + +G ++ Q+ Sbjct: 66 TLYHEHIVKYKGCCEDQGE----KSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQIC 121 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY-------VVTRWY 191 +G+ Y+HA IHR L N+ ++ D +KI DFGLA+ Y WY Sbjct: 122 EGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 181 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APE + Y D+WS G + E++T + S+ +P +F + Sbjct: 182 -APECLKECKFY-YASDVWSFGVTLYELLT----YCDSNQ------------SPHTKFTE 223 Query: 252 RLQSDEAKNYMKGLPE-LEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 + + + + L E LE+ + +L++ +A R T Sbjct: 224 LIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >5X5O-A nrPDB Length = 310 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 130/323 (40%), Gaps = 61/323 (18%) Query: 34 GSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVF 93 G G++G+V A +VA+KKL + +E +L + H N+I V Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHRNIIQFYGVI 73 Query: 94 TPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK---LGEDRIQFLVYQMLKGLRYIHAA-- 147 ++ +V + L + + + D I + KG+ Y+H Sbjct: 74 LEPP------NYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP 127 Query: 148 -GIIHRDLKPGNLAVNEDCELKILDFGLAR-QADSEMTGYVVTRWYRAPEVILNWMRYTQ 205 +IHRDLK N+ + D LKI DFG +R + V T + APEVI + + ++ Sbjct: 128 VKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS-LPVSE 186 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 T D +S G ++ EM+T + FKG + L +++ Sbjct: 187 TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE------------------------- 221 Query: 266 PELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQ-VQ 324 K + +I ++ LL + DA++R + + ++ ES+ + P Sbjct: 222 ----KNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIIS--ILESMSNDTSLPDKCN 275 Query: 325 KYDDS----FDDVDRTLDEWKRV 343 + + +++ TL+ K++ Sbjct: 276 SFLHNKAEWRCEIEATLERLKKL 298 >3QA8-A nrPDB Length = 676 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 83/298 (27%), Positives = 126/298 (42%), Gaps = 25/298 (8%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 T WE++ + +G+G +G V + TG +VAIK+ + S +R E++ Sbjct: 12 TCGPWEMK------ERLGTGGFGYVLRWIHQDTGEQVAIKQCRQEL-SPKNRERWCLEIQ 64 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH----EKLGEDRIQ 131 ++K + H NV+ +V + L L M + G DL K + L E I+ Sbjct: 65 IMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIR 124 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSE--MTGYV 186 L+ + LRY+H IIHRDLKP N+ + + KI+D G A++ D T +V Sbjct: 125 TLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFV 184 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 T Y APE +L +YT TVD WS G + E ITG F + Q ++ Sbjct: 185 GTLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEH 243 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE 304 L + + P A L L+ ML+ QR T + Sbjct: 244 IVVYDDLTGAVKFSSVLPTPNHLSGILAGKLERW-------LQCMLMWHQRQRGTDPQ 294 >3DKO-A nrPDB Length = 318 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 112/260 (43%), Gaps = 22/260 (8%) Query: 6 PARSGFYRQEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRP 61 P + V + A E+ A + + +G+G +G VCS G + VAIK L Sbjct: 23 PETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVG 82 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLM 120 + +E + E ++ H NV+ L V T + +V+ FM L + Sbjct: 83 Y-TEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKP------VMIVIEFMENGALDAFL 135 Query: 121 KHE--KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 + + ++ ++ + G+RY+ G +HRDL N+ VN + K+ DFGL+R Sbjct: 136 RKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 195 Query: 179 DSEMTGYVVTRW------YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 + + T + APE I + ++T D+WS G +M E+++ G+ + + Sbjct: 196 EDDPEAVYTTTGGKIPVRWTAPEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN 254 Query: 232 LDQLKEIMKVTGTPPAEFVQ 251 D +K I + P Sbjct: 255 QDVIKAIEEGYRLPAPMDCP 274 >3ORP-A nrPDB Length = 311 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 120/280 (42%), Gaps = 16/280 (5%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRL 77 T + Y + +G G V A D R VA+K L + F R RE + Sbjct: 6 TPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQN 65 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-KLGEDRIQFLVY 135 + H ++ + D T + Y+VM ++ G L ++ E + R ++ Sbjct: 66 AAALNHPAIVAVYD--TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA 123 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA------DSEMTGYVVTR 189 + L + H GIIHRD+KP N+ ++ +K++DFG+AR ++ + T Sbjct: 124 DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 183 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 Y +PE D++S+GC++ E++TG+ F G + + ++ PP+ Sbjct: 184 QYLSPEQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSAR 242 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 + L +D +K L K+ + A+ + +L+ Sbjct: 243 HEGLSADLDAVVLKAL----AKNPENRYQTAAEMRADLVR 278 >3DLS-A nrPDB Length = 335 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 127/304 (41%), Gaps = 54/304 (17%) Query: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP------FQSELFAKRAYRE 74 E Y + P+GSGA+G V +AVD +V +K + + + + + E Sbjct: 20 GEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLE 79 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG---KLMKHEKLGEDRIQ 131 + +L + H N+I +LD+F ++ F LVM G+ L + +H +L E Sbjct: 80 IAILSRVEHANIIKVLDIF------ENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLAS 133 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTR 189 ++ Q++ + Y+ IIHRD+K N+ + ED +K++DFG A + + T Sbjct: 134 YIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTI 193 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 Y APEV++ +++WS+G + ++ + F +L+E ++ PP Sbjct: 194 EYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPF------CELEETVEAAIHPPYLV 247 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 + L S L+ +L E+R T + + P Sbjct: 248 SKELMS-------------------------------LVSGLLQPVPERRTTLEKLVTDP 276 Query: 310 YFES 313 + Sbjct: 277 WVTQ 280 >5TQX-A nrPDB Length = 655 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 125/290 (43%), Gaps = 26/290 (8%) Query: 20 AWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 WE+R + +G+G +G VC K+AIK ++ +R E++++K Sbjct: 9 PWEMR------ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMK 61 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----LGEDRIQFLV 134 + H NV+ DV L L M + G DL KL+ + L E +I L+ Sbjct: 62 KLNHANVVKACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLL 120 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAV-NEDCEL--KILDFGLARQADSE--MTGYVVTR 189 + G+RY+H IIHRDLKP N+ + + ++ KI+D G A+ D T +V T Sbjct: 121 SDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTL 180 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 Y APE+ N YT TVD WS G ++ E I G F E +K Sbjct: 181 QYLAPELFEN-KPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFA 239 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 + + + + P S+ + N L+ ML D +QR Sbjct: 240 CEEMSGEVRFSSHLPQPN-------SLCSLIVEPMENWLQLMLNWDPQQR 282 >5HI2-A nrPDB Length = 283 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 125/288 (43%), Gaps = 34/288 (11%) Query: 17 TKTAWEVRA-VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 + WE+ Q +GSG++G V VA+K L + + E+ Sbjct: 11 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEV 62 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQF 132 +L+ RH N++ + T + +V + G+ L + K ++ Sbjct: 63 GVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHASETKFEMKKLID 115 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-----QADSEMTGYVV 187 + Q +G+ Y+HA IIHRDLK N+ ++ED +KI DFGLA + Sbjct: 116 IARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSG 175 Query: 188 TRWYRAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 + + APEVI + Y+ D+++ G ++ E++TG+ + ++ DQ+ E++ Sbjct: 176 SILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLS 235 Query: 246 PAEFVQRLQSDEAKNYMKGLPEL------EKKDFASILTNASPLAVNL 287 P + +++S+ K + + E E+ F IL LA L Sbjct: 236 P--DLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >6DBN-A nrPDB Length = 316 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 68/319 (21%), Positives = 127/319 (39%), Gaps = 37/319 (11%) Query: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDG----RTGAKVAIKKL 58 +P EV T +E R + + ++ +G G +G V TG +VA+K L Sbjct: 14 NPDIVSEKKPATEVDPTHFEKRFL-KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSL 72 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG 117 +P +E+ +L+++ HEN++ + T D L+M F+ L Sbjct: 73 -KPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDG----GNGIKLIMEFLPSGSLK 127 Query: 118 KLM--KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 + + K+ + Q+ KG+ Y+ + +HRDL N+ V + ++KI DFGL Sbjct: 128 EYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLT 187 Query: 176 RQADSEMTGYVV------TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 + +++ Y V ++ APE ++ Y D+WS G + E++T + S Sbjct: 188 KAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLT----YCDS 242 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPE-LEKKDFASILTNASPLAVNLL 288 D +P A F++ + + + L L++ N L+ Sbjct: 243 DS------------SPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLM 290 Query: 289 EKMLVLDAEQRVTAGEALA 307 K R + + Sbjct: 291 RKCWEFQPSNRTSFQNLIE 309 >6GQK-A nrPDB Length = 328 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 66/319 (20%), Positives = 120/319 (37%), Gaps = 68/319 (21%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAYR 73 WE R + +G+GA+G V A + VA+K L +P + Sbjct: 35 KWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML-KPSAHSTEREALMS 93 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-------- 124 EL++L ++ HEN++ LL T T++ DL ++ ++ Sbjct: 94 ELKVLSYLGNHENIVNLLGACTHGGPTLVITEYC-----CYGDLLNFLRRKRDEFVPYKV 148 Query: 125 ---------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 L + + YQ+ KG+ ++ + IHRDL N+ + KI DFGLA Sbjct: 149 APEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLA 208 Query: 176 RQADSEM------TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 R ++ + +W APE I N + YT D+WS G + E+ + G + + G Sbjct: 209 RDIKNDSNYVDKGNARLPVKW-MAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPG 266 Query: 229 SDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLL 288 + +++K + + PE +++ Sbjct: 267 MPVDSKFYKMIK------------------EGFRMSSPEYAP-----------AEMYDIM 297 Query: 289 EKMLVLDAEQRVTAGEALA 307 + D ++R T + + Sbjct: 298 KTCWDADPDKRPTFKQIVQ 316 >5A46-A nrPDB Length = 386 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 83/405 (20%), Positives = 146/405 (36%), Gaps = 80/405 (19%) Query: 2 SSPPPARSGFYRQEVTKTA-WEV-RAVYRDLQPVGSGAYGAVCSA------VDGRTGA-K 52 SS P +G E+ + WE+ R +P+G G +G V A D K Sbjct: 15 SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK 74 Query: 53 VAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPF 111 VA+K L +E E+ ++K + +H+N+I LL T D L Y+++ + Sbjct: 75 VAVKMLKSDA-TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEY 127 Query: 112 M-GTDLGKLMKHEK-----------------LGEDRIQFLVYQMLKGLRYIHAAGIIHRD 153 +L + ++ + L + YQ+ +G+ Y+ + IHRD Sbjct: 128 ASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD 187 Query: 154 LKPGNLAVNEDCELKILDFGLARQADS------EMTGYVVTRWYRAPEVILNWMRYTQTV 207 L N+ V ED +KI DFGLAR G + +W APE + + + YT Sbjct: 188 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQS 245 Query: 208 DIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 D+WS G ++ E+ T G + + G + +E +K Sbjct: 246 DVWSFGVLLWEIFTLGGSPYPG------------------------VPVEELFKLLKEGH 281 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKY 326 ++K +N + ++ QR T + + + + + Sbjct: 282 RMDKP------SNCTNELYMMMRDCWHAVPSQRPTFKQLVED--LDRIVALTSNQEYLDL 333 Query: 327 DDSFDDVDRTLDEWKRVTYK----EVLSFKPPRQLGARVSKETPL 367 D + + + T V S +P + L Sbjct: 334 SMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQL 378 >3OMV-A nrPDB Length = 307 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 127/299 (42%), Gaps = 40/299 (13%) Query: 21 WEVRAVYRDLQP-VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK 79 WE+ A L +GSG++G V VA+K L + + E+ +L+ Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 80 HMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQFLVYQ 136 RH N++ + T D + +V + G+ L K + + K ++ + Q Sbjct: 88 KTRHVNILLFMGYMTKD-------NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQ 140 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-----QADSEMTGYVVTRWY 191 +G+ Y+HA IIHRD+K N+ ++E +KI DFGLA ++ + + Sbjct: 141 TAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLW 200 Query: 192 RAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 APEVI + ++ D++S G ++ E++TG+ + ++ DQ+ ++ Sbjct: 201 MAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMV---------- 250 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAH 308 + S + K P+ K+ A + L ++L ++ E L H Sbjct: 251 GRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEE-RPLFPQIL--------SSIELLQH 300 >3LLT-A nrPDB Length = 360 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 73/362 (20%), Positives = 140/362 (38%), Gaps = 65/362 (17%) Query: 6 PARSGFYRQ---EVTKTAWE----VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL 58 R Y Q E+ +W+ + + ++ +G G +G V A+K + Sbjct: 9 SGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVV 68 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENV-----IGLLDVFTPDETLDDFTDFYLVMPFMG 113 + + + A E +LK ++++++ + + L+ +G Sbjct: 69 RNI---KKYTRSAKIEADILKKIQNDDINNNNIVKYHG------KFMYYDHMCLIFEPLG 119 Query: 114 TDLGKLM---KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE------- 163 L +++ + + I+ ++LK L Y+ + H DLKP N+ +++ Sbjct: 120 PSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSL 179 Query: 164 ------------------DCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQ 205 +K++DFG A + TR YRAPEVILN + + Sbjct: 180 ITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSIINTRQYRAPEVILN-LGWDV 238 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM-KG 264 + D+WS GC++AE+ TG LF+ +H++ L + + P + Y+ K Sbjct: 239 SSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKD 298 Query: 265 LPELEKKDFASILTNAS--------------PLAVNLLEKMLVLDAEQRVTAGEALAHPY 310 +L + AS + + L + L +L +D R + E L H + Sbjct: 299 ELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKF 358 Query: 311 FE 312 E Sbjct: 359 LE 360 >3QGY-A nrPDB Length = 286 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 113/265 (42%), Gaps = 20/265 (7%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 +Q +GSG +G V KVAIK + SE E ++ + H ++ Sbjct: 30 TFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSE---DDFIEEAEVMMKLSHPKLV 85 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTD-LGKLMKHEK--LGEDRIQFLVYQMLKGLRYI 144 L V + LV FM L ++ ++ + + + + +G+ Y+ Sbjct: 86 QLYGVCLEQAPI------CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYL 139 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEVILNW 200 A +IHRDL N V E+ +K+ DFG+ R D + T T++ + +PEV ++ Sbjct: 140 EEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV-FSF 198 Query: 201 MRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 RY+ D+WS G +M E+ + GK ++ + + +++I Sbjct: 199 SRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMN 258 Query: 260 NYMKGLPELEKKDFASILTNASPLA 284 + K PE ++ F+ +L + +A Sbjct: 259 HCWKERPE-DRPAFSRLLRQLAEIA 282 >3TT0-A nrPDB Length = 382 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 76/344 (22%), Positives = 128/344 (37%), Gaps = 83/344 (24%) Query: 6 PARSGFYRQEV----------TKTAWEV-RAVYRDLQPVGSGAYGAVCSA------VDGR 48 P Y Q + WE+ R +P+G GA+G V A D Sbjct: 39 PTTENLYFQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKP 98 Query: 49 TGA-KVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFY 106 KVA+K L +E E+ ++K + +H+N+I LL T D L Y Sbjct: 99 NRVTKVAVKMLKSDA-TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL------Y 151 Query: 107 LVMPFM-GTDLGKLMKHEK-----------------LGEDRIQFLVYQMLKGLRYIHAAG 148 +++ + +L + ++ + L + YQ+ +G+ Y+ + Sbjct: 152 VIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 211 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLARQADS------EMTGYVVTRWYRAPEVILNWMR 202 IHRDL N+ V ED +KI DFGLAR G + +W APE + + + Sbjct: 212 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI- 269 Query: 203 YTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNY 261 YT D+WS G ++ E+ T G + + G + +E Sbjct: 270 YTHQSDVWSFGVLLWEIFTLGGSPYPG------------------------VPVEELFKL 305 Query: 262 MKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 +K ++K +N + ++ QR T + Sbjct: 306 LKEGHRMDKP------SNCTNELYMMMRDCWHAVPSQRPTFKQL 343 >5U6B-A nrPDB Length = 307 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 113/293 (38%), Gaps = 47/293 (16%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGA--KVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +G G +GAV + + KVA+K + + + E +K H NV Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRI-------QFLVYQML 138 + L+ V + F +++PFM DL + + +LG+ + + + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW-----YRA 193 G+ Y+ IHRDL N +NE+ + + DFGL+++ + + A Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 E + + + YT D+WS G M E+ T G+T + G ++ + Sbjct: 207 IESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIY----------------- 248 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 +Y++ L++ + L+ + L+ + R + E Sbjct: 249 -------DYLRQGNRLKQP------ADCLDGLYALMSRCWELNPQDRPSFTEL 288 >4LFI-A nrPDB Length = 374 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 83/354 (23%), Positives = 155/354 (43%), Gaps = 50/354 (14%) Query: 8 RSGFYRQEVTKTAWEVRAV-YRDLQPVGSGAYGAVCSAVDGRTGAKVAI----------- 55 ++ E T W Y VG G Y V V + K+ I Sbjct: 22 TEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKI 81 Query: 56 -----------------------KKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 K Y Q E K + H H N+I L D+ Sbjct: 82 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 141 Query: 93 FTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHR 152 + LV ++ +++ + KL + I+F ++++LK L Y H+ GI+HR Sbjct: 142 IKDPISKTPA----LVFEYVDNVDFRIL-YPKLTDLEIRFYMFELLKALDYCHSMGIMHR 196 Query: 153 DLKPGNLAVN-EDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQTVDI 209 D+KP N+ ++ ++ +L+++D+GLA + E V +R+++ PE+++++ Y ++D+ Sbjct: 197 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 256 Query: 210 WSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPEL 268 WS G ++A MI + F G+ + DQL +I+KV GT E + + Sbjct: 257 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 316 Query: 269 EKKDFASILTN------ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 +K + + + + ++L++ +L D ++R+TA EA+ HP+F + + Sbjct: 317 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 370 >3QUP-A nrPDB Length = 323 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 112/292 (38%), Gaps = 48/292 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTG---AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + + +G G +G+V A + KVA+K L + + RE +K H Sbjct: 25 FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH 84 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGED-------RIQFLVY 135 +V L+ V +++PFM DL + ++GE+ + + Sbjct: 85 PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMV 144 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW----- 190 + G+ Y+ + IHRDL N + ED + + DFGL+R+ S Sbjct: 145 DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK 204 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 + A E + + + YT D+W+ G M E++T G+T + G ++ + Sbjct: 205 WLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIY-------------- 249 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 NY+ G L++ +L+ + D +QR + Sbjct: 250 ----------NYLIGGNRLKQP------PECMEEVYDLMYQCWSADPKQRPS 285 >3SXS-A nrPDB Length = 268 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 117/268 (43%), Gaps = 20/268 (7%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R L+ +GSG +G V VA+K + SE ++E + + + H Sbjct: 7 REEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSH 62 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEK-LGEDRIQFLVYQMLKG 140 ++ V + + + Y+V ++ G L L H K L ++ + Y + +G Sbjct: 63 PKLVKFYGVCSKEYPI------YIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEG 116 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEV 196 + ++ + IHRDL N V+ D +K+ DFG+ R D + V T++ + APEV Sbjct: 117 MAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV 176 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 ++ +Y+ D+W+ G +M E+ + GK + + + + ++ + Sbjct: 177 -FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIY 235 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPL 283 + LPE ++ F +L++ PL Sbjct: 236 QIMYSCWHELPE-KRPTFQQLLSSIEPL 262 >6E4F-A nrPDB Length = 290 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 110/256 (42%), Gaps = 23/256 (8%) Query: 9 SGFYRQE---VTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQS 64 Y Q + +WE+ L+ +G+G +G V VAIK + S Sbjct: 11 ENLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMS 69 Query: 65 ELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMK- 121 E E +++ ++ HE ++ L V T + +++ +M G L L + Sbjct: 70 E---DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREM 120 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DS 180 + ++ + + + + Y+ + +HRDL N VN+ +K+ DFGL+R D Sbjct: 121 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD 180 Query: 181 EMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLK 236 E T V +++ + PEV++ + +++ DIW+ G +M E+ + GK ++ + + + Sbjct: 181 EYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAE 239 Query: 237 EIMKVTGTPPAEFVQR 252 I + Sbjct: 240 HIAQGLRLYRPHLASE 255 >5KMM-A nrPDB Length = 329 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 109/273 (39%), Gaps = 41/273 (15%) Query: 32 PVGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 +G GA+G V A + + VA+K L SE + RE LL ++H+++ Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQDFQREAELLTMLQHQHI 99 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE----------------KLGEDR 129 + V T L +V +M DL + ++ LG + Sbjct: 100 VRFFGVCTEGRPL------LMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQ 153 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTR 189 + + Q+ G+ Y+ +HRDL N V + +KI DFG++R S V R Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR 213 Query: 190 -----WYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTG 243 + PE IL + ++T D+WS G ++ E+ T GK + + + + I + Sbjct: 214 TMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR- 271 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASI 276 R E M+G + E + SI Sbjct: 272 ---ELERPRACPPEVYAIMRGCWQREPQQRHSI 301 >4XCU-A nrPDB Length = 300 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 123/309 (39%), Gaps = 62/309 (20%) Query: 21 WEV-RAVYRDLQPVGSGAYGAVCSAV-------DGRTGAKVAIKKLYRPFQSELFAKRAY 72 WE R +P+G G +G V A + VA+K L + S+ Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASDKDLADLV 70 Query: 73 RELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK------- 124 E+ ++K + RH+N+I LL V T + L + +V +L + ++ + Sbjct: 71 SEMEVMKLIGRHKNIINLLGVCTQEGPL-----YVIVECAAKGNLREFLRARRPPGSSEG 125 Query: 125 -LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS--- 180 L + YQ+ +G++Y+ + IHRDL N+ V ED +KI DFGLAR Sbjct: 126 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 185 Query: 181 ---EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLK 236 G + +W APE + + + YT D+WS G ++ E+ T G + + G Sbjct: 186 YKKTSNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPG-------- 235 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 + +E + ++ +++ + P L+ + Sbjct: 236 ----------------IPVEELFSLLREGHRMDRP------PHCPPELYGLMRECWHAAP 273 Query: 297 EQRVTAGEA 305 QR T + Sbjct: 274 SQRPTFKQL 282 >5B2L-A nrPDB Length = 324 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 121/304 (39%), Gaps = 46/304 (15%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL-LKHMRHENV 86 +L +GSG G V +TG +A+K++ R E KR +L + LK + Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKE-ENKRILMDLDVVLKSHDCPYI 78 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYI 144 + F + TD ++ M MGT KL K + E + + ++K L Y+ Sbjct: 79 VQCFGTFITN------TDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYL 132 Query: 145 -HAAGIIHRDLKPGNLAVNEDCELKILDFGLA-RQADSEMTGY-VVTRWYRAPEVIL--- 198 G+IHRD+KP N+ ++E ++K+ DFG++ R DS+ Y APE I Sbjct: 133 KEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 199 -NWMRYTQTVDIWSVGCIMAEMITGKTLFKGS-DHLDQLKEIMKVTGTPPAEFVQRLQSD 256 Y D+WS+G + E+ TG+ +K + L ++++ Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ---------------- 236 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 E+ S + ++ L D +R + L H + + Sbjct: 237 ------------EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYET 284 Query: 317 TEDE 320 E + Sbjct: 285 LEVD 288 >5UIU-A nrPDB Length = 323 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 62/238 (26%), Positives = 99/238 (41%), Gaps = 22/238 (9%) Query: 10 GFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL--YRPFQSELF 67 FY + ++ R + +G G +G V T VA+KKL +E Sbjct: 32 SFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEEL 89 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM---KH 122 ++ +E++++ +HEN++ LL D D LV +M G+ L +L Sbjct: 90 KQQFDQEIKVMAKCQHENLVELLGF------SSDGDDLCLVYVYMPNGSLLDRLSCLDGT 143 Query: 123 EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM 182 L + G+ ++H IHRD+K N+ ++E KI DFGLAR ++ Sbjct: 144 PPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFA 203 Query: 183 TGY-----VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 V T Y APE + + T DI+S G ++ E+ITG L Sbjct: 204 QTVMTSRIVGTTAYMAPEALRGEI--TPKSDIYSFGVVLLEIITGLPAVDEHREPQLL 259 >4XI2-A nrPDB Length = 446 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 53/242 (21%), Positives = 107/242 (44%), Gaps = 20/242 (8%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 +WE+ L+ +G+G +G V VAIK + SE E +++ Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMSE---DEFIEEAKVM 236 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMK-HEKLGEDRIQFLVY 135 ++ HE ++ L V T + +++ +M G L L + + ++ + Sbjct: 237 MNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMCK 290 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---Y 191 + + + Y+ + +HRDL N VN+ +K+ DFGL+R D E T V +++ + Sbjct: 291 DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRW 350 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 PEV++ + +++ DIW+ G +M E+ + GK ++ + + + I + Sbjct: 351 SPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLA 409 Query: 251 QR 252 Sbjct: 410 SE 411 >4M7I-A nrPDB Length = 299 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 127/290 (43%), Gaps = 37/290 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +Q +G G +G V A + AIK++ P EL ++ RE++ L + H + Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGI 65 Query: 87 IGLLDVFTPDETLDDFT------DFYLVMPFM-GTDLGKLMKHEKLGEDRIQ----FLVY 135 + + + T + Y+ M +L M E+R + + Sbjct: 66 VRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFL 125 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------------- 181 Q+ + + ++H+ G++HRDLKP N+ D +K+ DFGL D + Sbjct: 126 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 185 Query: 182 -MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 TG V T+ Y +PE I Y+ VDI+S+G I+ E++ F S +++++ + Sbjct: 186 RHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL---YPF--STQMERVRTLTD 239 Query: 241 VTG-TPPAEFVQRLQSD--EAKNYMKGLPELEKKDFASILTNASPLAVNL 287 V P F Q+ + ++ + P +E+ + +I+ NA ++ Sbjct: 240 VRNLKFPPLFTQKYPCEYVMVQDMLSPSP-MERPEAINIIENAVFEDLDF 288 >3M42-A nrPDB Length = 299 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 62/330 (18%), Positives = 117/330 (35%), Gaps = 62/330 (18%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH-ENVIGL 89 Q +G G G V + RT K A+K L +A RE+ L +++ + Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 76 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDRIQFLVYQMLKGLRYIH 145 +DV+ + +VM + G +L ++ + E ++ + + ++Y+H Sbjct: 77 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 134 Query: 146 AAGIIHRDLKPGNLAVNE---DCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMR 202 + I HRD+KP NL + LK+ DFG A++ E + Sbjct: 135 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE--------------------K 174 Query: 203 YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYM 262 Y ++ D+WS+G IM ++ G F + L + Sbjct: 175 YDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTRIR 215 Query: 263 KGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQ 322 G E +++ S L+ +L + QR+T E + HP+ P Sbjct: 216 MGQYEFPNPEWS----EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 271 Query: 323 VQKYDDSFDDVDRTLDEWKRVTYKEVLSFK 352 + ++ K + + + Sbjct: 272 --HTSRVLKEDKERWEDVKEEMTSALATMR 299 >3GQL-A nrPDB Length = 326 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 124/319 (38%), Gaps = 73/319 (22%) Query: 21 WEV-RAVYRDLQPVGSGAYGAVCSA------VDGRTGA-KVAIKKLYRPFQSELFAKRAY 72 WE+ R +P+G GA+G V A D KVA+K L +E Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA-TEKDLSDLI 81 Query: 73 RELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK------ 124 E+ ++K + +H+N+I LL T D L Y+++ + +L + ++ + Sbjct: 82 SEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKGNLREYLQARRPPGLEY 135 Query: 125 -----------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 L + YQ+ +G+ Y+ + IHRDL N+ V ED +KI DFG Sbjct: 136 CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFG 195 Query: 174 LARQADS------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLF 226 LAR G + +W APE + + + YT D+WS G ++ E+ T G + + Sbjct: 196 LARDIHHIDYYKKTTNGRLPVKW-MAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPY 253 Query: 227 KGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN 286 G + +E +K ++K +N + Sbjct: 254 PG------------------------VPVEELFKLLKEGHRMDKP------SNCTNELYM 283 Query: 287 LLEKMLVLDAEQRVTAGEA 305 ++ QR T + Sbjct: 284 MMRDCWHAVPSQRPTFKQL 302 >4PDO-A nrPDB Length = 299 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 107/261 (40%), Gaps = 23/261 (8%) Query: 6 PARSGFYRQEVTKTAWEVRAVY-RDLQPVGSGAYGAVCSAVDG----RTGAKVAIKKLYR 60 P Q V K E+ + +G+G +G V + + VAIK L Sbjct: 14 PHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKA 73 Query: 61 PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKL 119 + +E E ++ H N+I L V + + + ++ +M L K Sbjct: 74 GY-TEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPM------MIITEYMENGALDKF 126 Query: 120 MKHE--KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ 177 ++ + + ++ ++ + G++Y+ +HRDL N+ VN + K+ DFGL+R Sbjct: 127 LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 186 Query: 178 ADSEMTGYVVTRW------YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSD 230 + + T + APE I ++ ++T D+WS G +M E++T G+ + Sbjct: 187 LEDDPEATYTTSGGKIPIRWTAPEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELS 245 Query: 231 HLDQLKEIMKVTGTPPAEFVQ 251 + + +K I P Sbjct: 246 NHEVMKAINDGFRLPTPMDCP 266 >4K33-A nrPDB Length = 325 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 132/336 (39%), Gaps = 74/336 (22%) Query: 5 PPARSGFYRQEVTKTA-WEV-RAVYRDLQPVGSGAYGAVCSA----VDGRTGAK---VAI 55 PP + E+ WE+ RA +P+G GA+G V A +D AK VA+ Sbjct: 14 PPTLANVSELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAV 73 Query: 56 KKLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-G 113 K L + ++ E+ ++K + +H+N+I LL T L Y+++ + Sbjct: 74 KML-KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPL------YVLVEYAAK 126 Query: 114 TDLGKLMKHEK-----------------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKP 156 +L + ++ + L + YQ+ +G+ Y+ + IHRDL Sbjct: 127 GNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 186 Query: 157 GNLAVNEDCELKILDFGLARQAD------SEMTGYVVTRWYRAPEVILNWMRYTQTVDIW 210 N+ V ED +KI DFGLAR G + +W APE + + + YT D+W Sbjct: 187 RNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKW-MAPEALFDRV-YTHQSDVW 244 Query: 211 SVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE 269 S G ++ E+ T G + + G + +E +K ++ Sbjct: 245 SFGVLLWEIFTLGGSPYPG------------------------IPVEELFKLLKEGHRMD 280 Query: 270 KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 K N + ++ + QR T + Sbjct: 281 KP------ANCTHDLYMIMRECWHAAPSQRPTFKQL 310 >3IO7-A nrPDB Length = 313 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 134/303 (44%), Gaps = 41/303 (13%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAV----DGRTGAKVAIKKLYRPFQSELFAKRAYRE 74 T +E R + + LQ +G G +G+V TG VA+KKL +E + RE Sbjct: 23 TQFEERHL-KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH--STEEHLRDFERE 79 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKH-EKLGEDRIQ 131 + +LK ++H+N++ V + L+M ++ G+ L KH E++ ++ Sbjct: 80 IEILKSLQHDNIVKYKGVCYSAGR----RNLKLIMEYLPYGSLRDYLQKHKERIDHIKLL 135 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY------ 185 Q+ KG+ Y+ IHRDL N+ V + +KI DFGL + + Y Sbjct: 136 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 195 Query: 186 -VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 WY APE + +++ D+WS G ++ E+ T ++ + + Sbjct: 196 ESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFT----------------YIEKSKS 237 Query: 245 PPAEFVQRLQSDE-AKNYMKGLPELEKKDFASILTNASPLAVNLL-EKMLVLDAEQRVTA 302 PPAEF++ + +D+ + + L EL K + + P + ++ + + QR + Sbjct: 238 PPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSF 297 Query: 303 GEA 305 + Sbjct: 298 RDL 300 >4C59-A nrPDB Length = 340 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 67/358 (18%), Positives = 127/358 (35%), Gaps = 64/358 (17%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRA-VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY 59 M SG + + E+ R + + G + V A D +G + A+K+L Sbjct: 2 MPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLL 61 Query: 60 RPFQSELFAKRAYRELRLLKHMR-HENVIGLLDV--FTPDETLDDFTDFYLVMPFMGTDL 116 E + +E+ +K + H N++ +E+ +F L+ L Sbjct: 62 S--NEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL 119 Query: 117 GKLMK----HEKLGEDRIQFLVYQMLKGLRYIHAAG--IIHRDLKPGNLAVNEDCELKIL 170 + +K L D + + YQ + ++++H IIHRDLK NL ++ +K+ Sbjct: 120 VEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLC 179 Query: 171 DFGLA---------------RQADSEMTGYVVTRWYRAPEVILNWMRY--TQTVDIWSVG 213 DFG A R E T YR PE+I + + + DIW++G Sbjct: 180 DFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALG 239 Query: 214 CIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDF 273 CI+ + + F+ L I+ + P Q Sbjct: 240 CILYLLCFRQHPFEDGAKL----RIVNGKYSIPPHDTQYT-------------------- 275 Query: 274 ASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFD 331 + +L+ ML ++ E+R++ E + + + + + + Sbjct: 276 ---------VFHSLIRAMLQVNPEERLSIAEVVHQ--LQEIAAARNVNPKSPITELLE 322 >4Y93-A nrPDB Length = 446 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 52/242 (21%), Positives = 107/242 (44%), Gaps = 20/242 (8%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 +WE+ L+ +G+G +G V VAIK + SE E +++ Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSE---DEFIEEAKVM 237 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMK-HEKLGEDRIQFLVY 135 ++ HE ++ L V T + +++ +M G L L + + ++ + Sbjct: 238 MNLSHEKLVQLYGVCTKQRPI------FIITEYMANGCLLNYLREMRHRFQTQQLLEMCK 291 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---Y 191 + + + Y+ + +HRDL N VN+ +K+ DFG+ R D E T +++ + Sbjct: 292 DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKW 351 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 +PEV++ + +++ DIW+ G +M E+ + GK ++ + + + I + P Sbjct: 352 ASPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLA 410 Query: 251 QR 252 Sbjct: 411 SE 412 >5HIE-A nrPDB Length = 302 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 126/288 (43%), Gaps = 34/288 (11%) Query: 17 TKTAWEVRA-VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL 75 + WE+ Q +GSG++G V VA+K L + + E+ Sbjct: 27 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEV 78 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMK--HEKLGEDRIQF 132 +L+ RH N++ + T + +V + G+ L + K ++ Sbjct: 79 GVLRKTRHVNILLFMGYSTKPQ-------LAIVTQWCEGSSLYHHLHIIETKFEMIKLID 131 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-----QADSEMTGYVV 187 + Q +G+ Y+HA IIHRDLK N+ ++ED +KI DFGLA + Sbjct: 132 IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG 191 Query: 188 TRWYRAPEVI--LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 + + APEVI + Y+ D+++ G ++ E++TG+ + ++ DQ+ ++ Sbjct: 192 SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLS 251 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKD------FASILTNASPLAVNL 287 P + +++S+ K + + E KK F IL + LA +L Sbjct: 252 P--DLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 297 >4XLV-A nrPDB Length = 328 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 116/345 (33%), Gaps = 68/345 (19%) Query: 6 PARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCS--AVDGRTGA---KVAIKKLY 59 A F WEV R L+ +G G++G V A D G +VA+K + Sbjct: 19 SASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN 78 Query: 60 RPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK 118 S E ++K +V+ LL V + + +VM M DL Sbjct: 79 -ESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPT------LVVMELMAHGDLKS 131 Query: 119 LMK-----------HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL 167 ++ + + ++ G+ Y++A +HRDL N V D + Sbjct: 132 YLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTV 191 Query: 168 KILDFGLARQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT- 221 KI DFG+ R + + APE + + + +T + D+WS G ++ E+ + Sbjct: 192 KIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV-FTTSSDMWSFGVVLWEITSL 250 Query: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 + ++G + LK +M + N Sbjct: 251 AEQPYQGLSNEQVLKFVMDGGYLDQPD------------------------------NCP 280 Query: 282 PLAVNLLEKMLVLDAEQRVTAGEALA------HPYFESLHDTEDE 320 +L+ + R T E + HP F + E Sbjct: 281 ERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSE 325 >4H1J-A nrPDB Length = 293 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 110/286 (38%), Gaps = 50/286 (17%) Query: 31 QPVGSGAYGAVCSAV---DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 + +G G +G V V VA+K + + ++ E ++K++ H +++ Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIV 88 Query: 88 GLLDVFTPDETLDDFTDFYLVMP-FMGTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYI 144 L+ + + T +++M + +LG ++ K L + Q+ K + Y+ Sbjct: 89 KLIGIIEEEPT-------WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 141 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTGYVVTRW---YRAPEVILNW 200 + +HRD+ N+ V +K+ DFGL+R D + VTR + +PE I N+ Sbjct: 142 ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NF 200 Query: 201 MRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 R+T D+W M E+++ GK F ++ D + + K P + Sbjct: 201 RRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP-------- 252 Query: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 P+ L+ + D R E Sbjct: 253 ----------------------PVLYTLMTRCWDYDPSDRPRFTEL 276 >2OGV-A nrPDB Length = 317 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 119/310 (38%), Gaps = 60/310 (19%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAYR 73 WE R + + +G+GA+G V A G KVA+K L ++ + Sbjct: 32 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEALMS 90 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE--------- 123 EL+++ H+ +HEN++ LL T + T++ DL ++ + Sbjct: 91 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-----CYGDLLNFLRRKAEADLDKED 145 Query: 124 --KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 L + Q+ +G+ ++ + IHRD+ N+ + KI DFGLAR ++ Sbjct: 146 GRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMND 205 Query: 182 MTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQL 235 V + + APE I + + YT D+WS G ++ E+ + G + G + Sbjct: 206 SNYIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF 264 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 +++K Y P K+ SI ++ L+ Sbjct: 265 YKLVK------------------DGYQMAQPAFAPKNIYSI-----------MQACWALE 295 Query: 296 AEQRVTAGEA 305 R T + Sbjct: 296 PTHRPTFQQI 305 >1LUF-A nrPDB Length = 343 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 63/291 (21%), Positives = 107/291 (36%), Gaps = 48/291 (16%) Query: 24 RAVYRDLQPVGSGAYGAVCSAV-----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 R ++ +G GA+G V A VA+K L +++ A RE L+ Sbjct: 46 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQA-DFQREAALM 104 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKH--------------- 122 + N++ LL V + + L+ +M DL + ++ Sbjct: 105 AEFDNPNIVKLLGVCAVGKPM------CLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLS 158 Query: 123 ----------EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF 172 L + Q+ G+ Y+ +HRDL N V E+ +KI DF Sbjct: 159 TRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADF 218 Query: 173 GLARQADS------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTL 225 GL+R S + + RW PE I + RYT D+W+ G ++ E+ + G Sbjct: 219 GLSRNIYSADYYKADGNDAIPIRW-MPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQP 276 Query: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASI 276 + G H + + + E + + LP ++ F SI Sbjct: 277 YYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPA-DRPSFCSI 326 >3KRL-A nrPDB Length = 335 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 120/316 (37%), Gaps = 66/316 (20%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAYR 73 WE R + + +G+GA+G V A G KVA+K L ++ + Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEALMS 98 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-------- 124 EL+++ H+ +HEN++ LL T + T++ DL ++ ++ Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-----CYGDLLNFLRRKRPPGLEYSY 153 Query: 125 ---------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 L + Q+ +G+ ++ + IHRD+ N+ + KI DFGLA Sbjct: 154 NPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 213 Query: 176 RQADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGS 229 R ++ V + + APE I + + YT D+WS G ++ E+ + G + G Sbjct: 214 RDIMNDSNYIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGI 272 Query: 230 DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 + +++K Y P K+ SI ++ Sbjct: 273 LVNSKFYKLVK------------------DGYQMAQPAFAPKNIYSI-----------MQ 303 Query: 290 KMLVLDAEQRVTAGEA 305 L+ R T + Sbjct: 304 ACWALEPTHRPTFQQI 319 >4XUF-A nrPDB Length = 297 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 121/306 (39%), Gaps = 49/306 (16%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVD---GRTG--AKVAIKKLYRPFQSELFAKRAYR 73 WE R + +GSGA+G V +A +TG +VA+K L S + Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS-EREALMS 61 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM-KHEKLGEDR 129 EL+++ + HEN++ LL T + YL+ + G L L K EK ED Sbjct: 62 ELKMMTQLGSHENIVNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSKREKFSEDE 115 Query: 130 IQF----------------------LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL 167 I++ YQ+ KG+ ++ +HRDL N+ V + Sbjct: 116 IEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVV 175 Query: 168 KILDFGLARQADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT- 221 KI DFGLAR S+ V + + APE + + YT D+WS G ++ E+ + Sbjct: 176 KICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSL 234 Query: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 G + G ++++ F ++E M+ + + S S Sbjct: 235 GVNPYPGIPVDANFYKLIQNGFKMDQPF---YATEEIYIIMQSCWAFDSRKRPSFPNLTS 291 Query: 282 PLAVNL 287 L L Sbjct: 292 FLGCQL 297 >6FEX-A nrPDB Length = 321 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 63/326 (19%), Positives = 118/326 (36%), Gaps = 71/326 (21%) Query: 24 RAVYRDLQPVGSGAYGAVCSA--------------VDGRTGA--KVAIKKLYRPFQSELF 67 R+ R + +G G +G V ++ R G VA+K L RP ++ Sbjct: 15 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL-RPDATKNA 73 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLG 126 +E++++ ++ N+I LL V D+ L ++ +M DL + + +L Sbjct: 74 RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL------CMITDYMENGDLNQFLSAHQLE 127 Query: 127 EDRI--------------QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF 172 + + Q+ G+RY+ +HRDL N V E+ +KI DF Sbjct: 128 DKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 187 Query: 173 GLARQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAE--MITGKTL 225 G++R + V R + A E IL ++T D+W+ G + E M+ Sbjct: 188 GMSRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQP 246 Query: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAV 285 F ++ N + + ++ + S Sbjct: 247 FGQLTDEQVIE-----------------------NAGEFFRDQGRQVYLSRPPACPQGLY 283 Query: 286 NLLEKMLVLDAEQRVTAGEALAHPYF 311 L+ + ++EQR + H + Sbjct: 284 ELMLRCWSRESEQRPPFSQL--HRFL 307 >3BEA-A nrPDB Length = 333 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 119/314 (37%), Gaps = 64/314 (20%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAYR 73 WE R + + +G+GA+G V A G KVA+K L ++ + Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEALMS 98 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE--------- 123 EL+++ H+ +HEN++ LL T + T++ DL ++ + Sbjct: 99 ELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC-----CYGDLLNFLRRKSRVLETDPA 153 Query: 124 ------KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ 177 L + Q+ +G+ ++ + IHRD+ N+ + KI DFGLAR Sbjct: 154 FAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARD 213 Query: 178 ADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDH 231 ++ V + + APE I + + YT D+WS G ++ E+ + G + G Sbjct: 214 IMNDSNYIVKGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILV 272 Query: 232 LDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKM 291 + +++K Y P K+ SI ++ Sbjct: 273 NSKFYKLVK------------------DGYQMAQPAFAPKNIYSI-----------MQAC 303 Query: 292 LVLDAEQRVTAGEA 305 L+ R T + Sbjct: 304 WALEPTHRPTFQQI 317 >2PSQ-A nrPDB Length = 370 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 131/335 (39%), Gaps = 74/335 (22%) Query: 6 PARSGFYRQEVTKTA-WEV-RAVYRDLQPVGSGAYGAVCSA----VDGRTGAK---VAIK 56 P +G E+ + WE R +P+G G +G V A +D + VA+K Sbjct: 60 PMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVK 119 Query: 57 KLYRPFQSELFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GT 114 L + +E E+ ++K + +H+N+I LL T D L Y+++ + Sbjct: 120 ML-KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVEYASKG 172 Query: 115 DLGKLMKHEK-----------------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPG 157 +L + ++ + + + YQ+ +G+ Y+ + IHRDL Sbjct: 173 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 232 Query: 158 NLAVNEDCELKILDFGLARQADS------EMTGYVVTRWYRAPEVILNWMRYTQTVDIWS 211 N+ V E+ +KI DFGLAR ++ G + +W APE + + + YT D+WS Sbjct: 233 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKW-MAPEALFDRV-YTHQSDVWS 290 Query: 212 VGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 G +M E+ T G + + G + +E +K ++K Sbjct: 291 FGVLMWEIFTLGGSPYPG------------------------IPVEELFKLLKEGHRMDK 326 Query: 271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 N + ++ QR T + Sbjct: 327 P------ANCTNELYMMMRDCWHAVPSQRPTFKQL 355 >5GNK-A nrPDB Length = 297 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 69/287 (24%), Positives = 125/287 (43%), Gaps = 24/287 (8%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMR 82 ++ ++ +GSGA+G V + G KV AIK+L R S K E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHE-KLGEDRIQFLVYQMLK 139 + +V LL + + L+M M G L + +H+ +G + Q+ K Sbjct: 80 NPHVCRLLGICLT-------STVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAK 132 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-----VTRWYRAP 194 G+ Y+ ++HRDL N+ V +KI DFGLA+ +E Y V + A Sbjct: 133 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 192 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRL 253 E IL+ + YT D+WS G + E++T G + G + + I++ P + + Sbjct: 193 ESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASE-ISSILEKGERLPQPPICTI 250 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + + F ++ S +A + ++ LV+ ++R+ Sbjct: 251 DVYMIMVKCWMIDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 296 >4NEU-A nrPDB Length = 333 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 66/331 (19%), Positives = 128/331 (38%), Gaps = 56/331 (16%) Query: 35 SGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFT 94 SG +G V G + +K +Y+ + E +++ +RH V+ LL V Sbjct: 34 SGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII 92 Query: 95 PDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQ-FLVYQMLKGLRYIHAAGIIHR 152 + + LVM +M +L ++K E ++ ++ ++++G+ Y+H G+IH+ Sbjct: 93 EEG------KYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHK 146 Query: 153 DLKPGNLAVNEDCELKILDFGLA----------------RQADSEMTGYVVTRWYRAPEV 196 DLKP N+ V+ D +KI D GLA R+ D T +Y APE Sbjct: 147 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEH 206 Query: 197 ILN-WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 + + + T+ D++S ++ + K ++ + QL +K P Sbjct: 207 LNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRP---------- 256 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT---AGEALAHPYFE 312 D I ++L++ + E R T E P++ Sbjct: 257 ----------------DVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFR-PFYL 299 Query: 313 SLHDTEDEPQVQKYDDSFDDVDRTLDEWKRV 343 S + E V+ + + + + + + Sbjct: 300 SQLEESVEEDVKSLKKEYSNENAVVKRMQSL 330 >3BBT-B nrPDB Length = 328 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 125/306 (40%), Gaps = 26/306 (8%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + ++ +GSGA+G V + G V AIK L + + E ++ M H Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASMDH 76 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHE-KLGEDRIQFLVYQMLKG 140 +++ LL V LV M G L + +H+ +G + Q+ KG Sbjct: 77 PHLVRLLGVCLSPT-------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKG 129 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV-----TRWYRAPE 195 + Y+ ++HRDL N+ V +KI DFGLAR + + Y + A E Sbjct: 130 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALE 189 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTP-PAEFVQRL 253 I ++ ++T D+WS G + E++T G + G + + K P P + Sbjct: 190 CI-HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDV 248 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 K +M K F + S +A + ++ LV+ + R+ +F++ Sbjct: 249 YMVMVKCWMIDADSRPK--FKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDSKFFQN 305 Query: 314 LHDTED 319 L D ED Sbjct: 306 LLDEED 311 >6B2Q-A nrPDB Length = 317 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 67/214 (31%), Positives = 106/214 (49%), Gaps = 9/214 (4%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHM 81 + YR + + +G G V AVD R G +VA+K L F S+ F +R E R + Sbjct: 30 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML 89 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLK 139 H + + D + + + YLVM + G L ++K +L ++ Q + Sbjct: 90 NHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 148 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS---EMTGYV-VTRWYRAPE 195 L+ HAAG++HRD+KPGN+ + ++KI DFG+A+ D+ TG V T Y APE Sbjct: 149 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 208 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 L + D++S+G + E ++GK F G Sbjct: 209 QALGH-DASPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 67/214 (31%), Positives = 106/214 (49%), Gaps = 9/214 (4%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHM 81 + YR + + +G G V AVD R G +VA+K L F S+ F +R E R + Sbjct: 10 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML 69 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLK 139 H + + D + + + YLVM + G L ++K +L ++ Q + Sbjct: 70 NHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 128 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS---EMTGYV-VTRWYRAPE 195 L+ HAAG++HRD+KPGN+ + ++KI DFG+A+ D+ TG V T Y APE Sbjct: 129 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 188 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 L + D++S+G + E ++GK F G Sbjct: 189 QALGH-DASPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 67/214 (31%), Positives = 106/214 (49%), Gaps = 9/214 (4%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHM 81 + YR + + +G G V AVD R G +VA+K L F S+ F +R E R + Sbjct: 9 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAML 68 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLK 139 H + + D + + + YLVM + G L ++K +L ++ Q + Sbjct: 69 NHPGIASVHD-YGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 127 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS---EMTGYV-VTRWYRAPE 195 L+ HAAG++HRD+KPGN+ + ++KI DFG+A+ D+ TG V T Y APE Sbjct: 128 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPE 187 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 L + D++S+G + E ++GK F G Sbjct: 188 QALGH-DASPASDVYSLGVVGYEAVSGKRPFAGD 220 >5O0Y-A nrPDB Length = 579 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 120/299 (40%), Gaps = 55/299 (18%) Query: 38 YGAVCSAVDGRTGAKVAIKK--LYRPFQSEL---FAKRAYRELRLLKHMRHENVIGLLDV 92 + V A D VA+K L + ++ E + K A RE R+ K + H ++ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 93 FTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKL-GEDRIQFLVYQMLKGLRYIHAAG-- 148 F+ D F V+ + G DL +K KL E + ++ Q++ L+Y++ Sbjct: 357 FSL-----DTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPP 411 Query: 149 IIHRDLKPGNLAVNED---CELKILDFGLARQADSEMTGYV----------VTRWYRAPE 195 IIH DLKPGN+ + E+KI DFGL++ D + V T WY PE Sbjct: 412 IIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPE 471 Query: 196 VILNWM---RYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 + + + VD+WSVG I + + G+ F G + Q + +Q Sbjct: 472 CFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ-------------DILQE 517 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 +A + K +P A + + L E R+ + PY Sbjct: 518 NTILKATEV-----QFPPK------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >5X02-A nrPDB Length = 347 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 121/313 (38%), Gaps = 46/313 (14%) Query: 12 YRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVD---GRTG--AKVAIKKLYRPFQSE 65 +R+ WE R + +GSGA+G V +A +TG +VA+K L S Sbjct: 34 FREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 93 Query: 66 LFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM-K 121 + EL+++ + HEN++ LL T + YL+ + G L L K Sbjct: 94 -EREALMSELKMMTQLGSHENIVNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSK 146 Query: 122 HEKLGEDRIQF----------------------LVYQMLKGLRYIHAAGIIHRDLKPGNL 159 EK ED I++ YQ+ KG+ ++ +HRDL N+ Sbjct: 147 REKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNV 206 Query: 160 AVNEDCELKILDFGLARQADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGC 214 V +KI DFGLAR S+ V + + APE + + YT D+WS G Sbjct: 207 LVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI-YTIKSDVWSYGI 265 Query: 215 IMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDF 273 ++ E+ + G + G ++++ F + ++ F Sbjct: 266 LLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 325 Query: 274 ASILTNASPLAVN 286 ++ + + Sbjct: 326 PNLTSFLGCQLAD 338 >4HVI-A nrPDB Length = 314 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 122/298 (40%), Gaps = 40/298 (13%) Query: 19 TAWEVRAVYRDLQPVGSGAYGAVCSAVDG----RTGAKVAIKKLYRPFQSELFAKRAYRE 74 T +E R + + + +G G +G+V TGA VA+K+L + RE Sbjct: 5 TIFEERHL-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH--SGPDQQRDFQRE 61 Query: 75 LRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHE-KLGEDRIQ 131 +++LK + + ++ V LVM ++ G L +H +L R+ Sbjct: 62 IQILKALHSDFIVKYRGVSYGPGR----QSLRLVMEYLPSGCLRDFLQRHRARLDASRLL 117 Query: 132 FLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV---- 187 Q+ KG+ Y+ + +HRDL N+ V + +KI DFGLA+ + YVV Sbjct: 118 LYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPG 177 Query: 188 ---TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 WY APE + + + +++ D+WS G ++ E+ T + + Sbjct: 178 QSPIFWY-APESLSDNI-FSRQSDVWSFGVVLYELFT----YCDKSC------------S 219 Query: 245 PPAEFVQRLQSDEA-KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 P AEF++ + S+ + L LE+ L++ + R + Sbjct: 220 PSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >3ZBF-A nrPDB Length = 322 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 74/349 (21%), Positives = 123/349 (35%), Gaps = 73/349 (20%) Query: 6 PARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGR-----TGA-KVAIKKL 58 P Y Q + R +GSGA+G V +G KVA+K L Sbjct: 13 PTTENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTL 72 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLG 117 + ++ +E L+ H N++ L V +E Y+++ M G DL Sbjct: 73 KKG-STDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQ------YIILELMEGGDLL 125 Query: 118 KLMKHEKL--------GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE--- 166 ++ ++ + L + KG Y+ IHRDL N V+ Sbjct: 126 TYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSP 185 Query: 167 --LKILDFGLARQADSE------MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 +KI DFGLAR G + RW APE +++ + +T D+WS G ++ E Sbjct: 186 RIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW-MAPESLMDGI-FTTQSDVWSFGILIWE 243 Query: 219 MIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL 277 ++T G + +LD L + P Sbjct: 244 ILTLGHQPYPAHSNLDVLNYVQTGGRLEPP------------------------------ 273 Query: 278 TNASPLAVNLLEKMLVLDAEQRVTAG------EALAHPYFESLHDTEDE 320 N NL+ + + +QR T + + + S++ + DE Sbjct: 274 RNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDE 322 >3LZB-A nrPDB Length = 327 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 68/271 (25%), Positives = 117/271 (43%), Gaps = 19/271 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMR 82 ++ ++ +GSGA+G V + G KV AIK+L R S K E ++ + Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 75 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGL 141 + +V LL + T+ T MPF G L + +H+ +G + Q+ KG+ Sbjct: 76 NPHVCRLLGICLTS-TVQLITQL---MPF-GCLLDYVREHKDNIGSQYLLNWCVQIAKGM 130 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-----VTRWYRAPEV 196 Y+ ++HRDL N+ V +KI DFGLA+ +E Y V + A E Sbjct: 131 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 190 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 IL+ + YT D+WS G + E++T G + G + + I++ P + + Sbjct: 191 ILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASE-ISSILEKGERLPQPPICTIDV 248 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVN 286 + + F ++ S +A + Sbjct: 249 YMIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >1FVR-A nrPDB Length = 327 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 112/300 (37%), Gaps = 64/300 (21%) Query: 32 PVGSGAYGAVCSAVDGRTGAKV--AIKKLYRPFQSELFAKRAYRELRLLKHM-RHENVIG 88 +G G +G V A + G ++ AIK++ + + S+ + EL +L + H N+I Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHRDFAGELEVLCKLGHHPNIIN 90 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK-----------------LGEDRI 130 LL + YL + + +L ++ + L ++ Sbjct: 91 LLGAC------EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEMTGYVV 187 + +G+ Y+ IHRDL N+ V E+ KI DFGL+R + + G + Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLP 204 Query: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPP 246 RW A E + N+ YT D+WS G ++ E+++ G T + G + ++ Sbjct: 205 VRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEK--------- 253 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 L + N +L+ + +R + + L Sbjct: 254 ---------------------LPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >6BSD-A nrPDB Length = 876 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 66/357 (18%), Positives = 121/357 (33%), Gaps = 80/357 (22%) Query: 2 SSPPPARSGFYRQEVTKTAWEV---RAVYRDLQPVGSGAYGAVCSA-------------- 44 A V V R+ R + +G G +G V Sbjct: 545 GGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFP 604 Query: 45 VDGRTGA--KVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDF 102 ++ R G VA+K L RP ++ +E++++ ++ N+I LL V D+ L Sbjct: 605 LNVRKGHPLLVAVKIL-RPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPL--- 660 Query: 103 TDFYLVMPFM-GTDLGKLMKHEKLGEDRI--------------------QFLVYQMLKGL 141 ++ +M DL + + +L + + Q+ G+ Sbjct: 661 ---CMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGM 717 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW-----YRAPEV 196 RY+ +HRDL N V E+ +KI DFG++R + V R + A E Sbjct: 718 RYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWEC 777 Query: 197 ILNWMRYTQTVDIWSVGCIMAE--MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 IL ++T D+W+ G + E M+ F ++ Sbjct: 778 IL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIE------------------ 818 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 N + + ++ + S L+ + ++EQR + H + Sbjct: 819 -----NAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--HRFL 868 >3BGP-A nrPDB Length = 333 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 128/314 (40%), Gaps = 54/314 (17%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAY 72 K + + Y+ +GSG +G+V S + VAIK + + S+ R Sbjct: 48 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 107 Query: 73 RELRLLKHMRH--ENVIGLLDVFTPDETLDDFTDFYLVMPFMG--TDLGKLM-KHEKLGE 127 E+ LLK + VI LLD F ++ F L++ DL + + L E Sbjct: 108 MEVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQE 161 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGL-ARQADSEMTGY 185 + + +Q+L+ +R+ H G++HRD+K N+ ++ ELK++DFG A D+ T + Sbjct: 162 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 221 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 TR Y PE I + ++ +WS+G ++ +M+ G F+ + Sbjct: 222 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-------------- 267 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 ++G ++ S +L+ L L R T E Sbjct: 268 ---------------IIRGQVFFRQR--------VSSECQHLIRWCLALRPSDRPTFEEI 304 Query: 306 LAHPYFESLHDTED 319 HP+ + + ++ Sbjct: 305 QNHPWMQDVLLPQE 318 >5TUR-A nrPDB Length = 404 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 71/314 (22%), Positives = 128/314 (40%), Gaps = 54/314 (17%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAY 72 K + + Y+ +GSG +G+V S + VAIK + + S+ R Sbjct: 119 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 178 Query: 73 RELRLLKHMRH--ENVIGLLDVFTPDETLDDFTDFYLVMPFMG--TDLGKLM-KHEKLGE 127 E+ LLK + VI LLD F ++ F L++ DL + + L E Sbjct: 179 MEVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQE 232 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGL-ARQADSEMTGY 185 + + +Q+L+ +R+ H G++HRD+K N+ ++ ELK++DFG A D+ T + Sbjct: 233 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 292 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 TR Y PE I + ++ +WS+G ++ +M+ G F+ + Sbjct: 293 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-------------- 338 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 ++G ++ S +L+ L L R T E Sbjct: 339 ---------------IIRGQVFFRQR--------VSSECQHLIRWCLALRPSDRPTFEEI 375 Query: 306 LAHPYFESLHDTED 319 HP+ + + ++ Sbjct: 376 QNHPWMQDVLLPQE 389 >3CJF-A nrPDB Length = 309 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 63/323 (19%) Query: 13 RQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSA----VDG-RTGAKVAIKKLYRPFQSEL 66 R + WE R +P+G GA+G V A +D T VA+K L + + Sbjct: 14 RLPYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML-KEGATHS 72 Query: 67 FAKRAYRELRLLKHMRHE-NVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK 124 + EL++L H+ H NV+ LL T +++ F +L ++ ++ Sbjct: 73 EHRALMSELKILIHIGHHLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKR 127 Query: 125 -------------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILD 171 L + + +Q+ KG+ ++ + IHRDL N+ ++E +KI D Sbjct: 128 NEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICD 187 Query: 172 FGLARQADSE-----MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTL 225 FGLAR + + + APE I + + YT D+WS G ++ E+ + G + Sbjct: 188 FGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASP 246 Query: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAV 285 + G EF +RL K + D+ +P Sbjct: 247 YPGVK--------------IDEEFCRRL---------KEGTRMRAPDYT------TPEMY 277 Query: 286 NLLEKMLVLDAEQRVTAGEALAH 308 + + QR T E + H Sbjct: 278 QTMLDCWHGEPSQRPTFSELVEH 300 >3KUL-B nrPDB Length = 325 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 53/236 (22%), Positives = 96/236 (40%), Gaps = 21/236 (8%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAK---VAIKKLYRPFQSELFAKRAYRELRLLKHM 81 + + +GSG G VC G + VAIK L + +E + E ++ Sbjct: 49 SRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGY-TERQRRDFLSEASIMGQF 107 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE--KLGEDRIQFLVYQML 138 H N+I L V T +V +M L ++ + ++ ++ + Sbjct: 108 DHPNIIRLEGVVTRGRLA------MIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVG 161 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW------YR 192 G+RY+ G +HRDL N+ V+ + K+ DFGL+R + + T + Sbjct: 162 AGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT 221 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAE-MITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 APE I + ++ D+WS G +M E + G+ + + D + + + P Sbjct: 222 APEAIA-FRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAP 276 >5EG3-A nrPDB Length = 334 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 71/320 (22%), Positives = 125/320 (39%), Gaps = 73/320 (22%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSA----VDGRTGAK---VAIKKLYRPFQSELFAKRA 71 WE R +P+G GA+G V A +D + VA+K L + +E Sbjct: 29 KWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML-KDDATEKDLSDL 87 Query: 72 YRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----- 124 E+ ++K + +H+N+I LL T D L Y+++ + +L + ++ + Sbjct: 88 VSEMEMMKMIGKHKNIINLLGACTQDGPL------YVIVAYASKGNLREYLRARRPPGME 141 Query: 125 ------------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF 172 + + YQ+ +G+ Y+ + IHRDL N+ V E+ +KI DF Sbjct: 142 LSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 201 Query: 173 GLARQAD------SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTL 225 GLAR + G + +W APE + + + YT D+WS G +M E+ T G + Sbjct: 202 GLARDINNIDFFKETTNGRLPVKW-MAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSP 259 Query: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAV 285 + G + +E +K ++K N + Sbjct: 260 YPG------------------------IPVEELFKLLKEGHRMDKP------ANCTNELY 289 Query: 286 NLLEKMLVLDAEQRVTAGEA 305 ++ QR T + Sbjct: 290 MMMRDCWHAVPSQRPTFKQL 309 >2WTK-B nrPDB Length = 373 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 74/362 (20%), Positives = 134/362 (37%), Gaps = 42/362 (11%) Query: 27 YRDLQPVGSGAYG---AVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 Y L +G G + V A TG V ++++ S EL + K H Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKH--EKLGEDRIQFLVYQMLK 139 N++ F D + ++V FM G+ + H + + E I +++ +LK Sbjct: 70 PNIVPYRATFIAD------NELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLK 123 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKI---------LDFGLARQADSEMTGY-VVTR 189 L YIH G +HR +K ++ ++ D ++ + + G ++ + Y V Sbjct: 124 ALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVL 183 Query: 190 WYRAPEVI-LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV------- 241 + +PEV+ N Y DI+SVG E+ G FK L E + Sbjct: 184 PWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLD 243 Query: 242 TGTPPAEFVQRLQSDEAKN--------YMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 T T PAE + S N P SP + +E+ L Sbjct: 244 TSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQ 303 Query: 294 LDAEQRVTAGEALAHPYFESL--HDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSF 351 + + R +A L H +F+ + +E P++ + + + + + + V + Sbjct: 304 RNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTNL 363 Query: 352 KP 353 + Sbjct: 364 EE 365 >4HZS-A nrPDB Length = 341 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 62/233 (26%), Positives = 95/233 (40%), Gaps = 22/233 (9%) Query: 28 RDLQPVGSGAYGAVCSAV-DGRTGAKV--AIKKLYRPFQSELFA-KRAYRELRLLKHMRH 83 R L+ +G G++G V D +G V A+K L S+ A RE+ + + H Sbjct: 15 RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH 74 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHE-KLGEDRIQFLVYQMLKG 140 N+I L V +V +G+ L +L KH+ + Q+ +G Sbjct: 75 RNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 127 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV------VTRWYRAP 194 + Y+ + IHRDL NL + +KI DFGL R YV V + AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPP 246 E + ++ D W G + EM T G+ + G + L +I K P Sbjct: 188 ESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLP 239 >4X7Q-B nrPDB Length = 312 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 120/317 (37%), Gaps = 58/317 (18%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP----FQSELFAKRAYR 73 K A YR +G G +G V + +VAIK + R + + Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 83 Query: 74 ELRLLKHMR----HENVIGLLDVFTPDETLDDFTDFYLVMP--FMGTDLGKLM-KHEKLG 126 E+ LL + H VI LLD F E F LV+ DL + + LG Sbjct: 84 EVALLWKVGAGGGHPGVIRLLDWFETQEG------FMLVLERPLPAQDLFDYITEKGPLG 137 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGL-ARQADSEMTG 184 E + Q++ +++ H+ G++HRD+K N+ ++ K++DFG A D T Sbjct: 138 EGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTD 197 Query: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + TR Y PE I + +WS+G ++ +M+ G F+ +EI++ Sbjct: 198 FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERD------QEILEAELH 251 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE 304 PA + SP L+ + L R + E Sbjct: 252 FPA-------------------------------HVSPDCCALIRRCLAPKPSSRPSLEE 280 Query: 305 ALAHPYFESLHDTEDEP 321 L P+ ++ ED P Sbjct: 281 ILLDPWMQT--PAEDVP 295 >4RC3-A nrPDB Length = 289 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 128/313 (40%), Gaps = 54/313 (17%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAYR 73 K + + Y+ +GSG +G+V S + VAIK + + S+ R Sbjct: 5 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 64 Query: 74 ELRLLKHMRH--ENVIGLLDVFTPDETLDDFTDFYLVMPFMG--TDLGKLM-KHEKLGED 128 E+ LLK + VI LLD F ++ F L++ DL + + L E+ Sbjct: 65 EVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEE 118 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGL-ARQADSEMTGYV 186 + +Q+L+ +R+ H G++HRD+K N+ ++ ELK++DFG A D+ T + Sbjct: 119 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD 178 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 TR Y PE I + ++ +WS+G ++ +M+ G F+ + Sbjct: 179 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------- 223 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 ++G ++ S +L+ L L R T E Sbjct: 224 --------------IIRGQVFFRQR--------VSSECQHLIRWCLALRPSDRPTFEEIQ 261 Query: 307 AHPYFESLHDTED 319 HP+ + + ++ Sbjct: 262 NHPWMQDVLLPQE 274 >4YFF-A nrPDB Length = 311 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 111/276 (40%), Gaps = 22/276 (7%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-RPFQSELFAKRAYRELRLLKHMRHENV 86 + +GSG++G V VAIK+ + S+ RE+ +L + H V Sbjct: 45 EFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 102 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRY 143 I + L+D + F +V ++ G L L+ +K L + + KG+ Y Sbjct: 103 IQFVGAC-----LNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEY 157 Query: 144 IH--AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWYRAPEVI 197 +H IIHRDL N+ + ED + DFG +R S MT + APEV Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVF 217 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDE 257 RYT D++S + E++TG+ F ++ PP + + Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS--IPKPI 275 Query: 258 AKNYMKGLPELE--KKDFASILTNASPLAVNLLEKM 291 + ++G + +F+ ++ N +E M Sbjct: 276 SSLLIRGWNACPEGRPEFSEVVMKLEECLCN-IELM 310 >3PP0-A nrPDB Length = 338 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 108/270 (40%), Gaps = 19/270 (7%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R ++ +GSGA+G V + G V AIK L R S K E ++ + Sbjct: 20 RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVL-RENTSPKANKEILDEAYVMAGVGS 78 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLR 142 V LL + T+ T MP+ G L + +LG + Q+ KG+ Sbjct: 79 PYVSRLLGICLTS-TVQLVTQL---MPY-GCLLDHVRENRGRLGSQDLLNWCMQIAKGMS 133 Query: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-----VTRWYRAPEVI 197 Y+ ++HRDL N+ V +KI DFGLAR D + T Y V + A E I Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESI 193 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 L R+T D+WS G + E++T G + G + + K P + Sbjct: 194 L-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPIC-TIDVY 251 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVN 286 + + F +++ S +A + Sbjct: 252 MIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >5VD3-A nrPDB Length = 311 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 65/291 (22%), Positives = 111/291 (38%), Gaps = 45/291 (15%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 + ++ L +G G+YG V G A+K+ PF+ R E+ + + + Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 115 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKG 140 H + L ++ ++ YL G L + + L E ++ + L Sbjct: 116 HPCCVRL------EQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLA 169 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV--VTRWYRAPEVIL 198 L ++H+ G++H D+KP N+ + K+ DFGL + + G V Y APE++ Sbjct: 170 LAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQ 229 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Y D++S+G + E+ L G + QL++ G P EF Sbjct: 230 G--SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEFT-------- 274 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 S ++L ML D + R TA LA P Sbjct: 275 -------------------AGLSSELRSVLVMMLEPDPKLRATAEALLALP 306 >5HVK-A nrPDB Length = 315 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 122/324 (37%), Gaps = 62/324 (19%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G G +G TG + +K+L R E + +E+++++ + H NV+ + Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRF--DEETQRTFLKEVKVMRCLEHPNVLKFI 77 Query: 91 DVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAAG 148 V D+ L+ T++ G L ++K + + + G+ Y+H+ Sbjct: 78 GVLYKDKRLNFITEYI-----KGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMN 132 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT-----------------GYVVTRWY 191 IIHR+L N V E+ + + DFGLAR E T V ++ Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APE+I N Y + VD++S G ++ E I+ P + Sbjct: 193 MAPEMI-NGRSYDEKVDVFSFGIVLCE-------------------IIGRVNADPDYLPR 232 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 + D N L + + +L D E+R + + L H + Sbjct: 233 TM--DFGLNVRGFLDRYCPPNCPPSFFPITVRCCDL-------DPEKRPSFVK-LEH-WL 281 Query: 312 ESLH-----DTEDEPQVQKYDDSF 330 E+L PQ+++ D F Sbjct: 282 ETLRMHLAGHLPLGPQLEQLDRGF 305 >4R7H-A nrPDB Length = 343 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 118/324 (36%), Gaps = 75/324 (23%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGA-----KVAIKKLYRPFQSELFAKRAYR 73 WE R + + +G+GA+G V A G KVA+K L ++ + Sbjct: 44 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHAD-EKEALMS 102 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-------- 123 EL+++ H+ +HEN++ LL T ++ + DL ++ + Sbjct: 103 ELKIMSHLGQHENIVNLLGACTHGGP------VLVITEYCTYGDLLNFLRRKAEAMLGPS 156 Query: 124 ----------------KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL 167 L + Q+ +G+ ++ + IHRD+ N+ + Sbjct: 157 LSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVA 216 Query: 168 KILDFGLARQADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT- 221 KI DFGLAR ++ V + + APE I + + YT D+WS G ++ E+ + Sbjct: 217 KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSV-YTVQSDVWSYGILLWEIFSL 275 Query: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 G + G + +++K Y P K+ SI Sbjct: 276 GLNPYPGILVNSKFYKLVK------------------DGYQMAQPAFAPKNIYSI----- 312 Query: 282 PLAVNLLEKMLVLDAEQRVTAGEA 305 ++ L+ R T + Sbjct: 313 ------MQACWALEPTHRPTFQQI 330 >1U54-B nrPDB Length = 291 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 62/233 (26%), Positives = 95/233 (40%), Gaps = 22/233 (9%) Query: 28 RDLQPVGSGAYGAVCSAV-DGRTGAKV--AIKKLYRPFQSELFA-KRAYRELRLLKHMRH 83 R L+ +G G++G V D +G V A+K L S+ A RE+ + + H Sbjct: 21 RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDH 80 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHE-KLGEDRIQFLVYQMLKG 140 N+I L V +V +G+ L +L KH+ + Q+ +G Sbjct: 81 RNLIRLYGVVLTPPMK-------MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 133 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV------VTRWYRAP 194 + Y+ + IHRDL NL + +KI DFGL R YV V + AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 195 EVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPP 246 E + ++ D W G + EM T G+ + G + L +I K P Sbjct: 194 ESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLP 245 >3G0E-A nrPDB Length = 336 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 118/321 (36%), Gaps = 70/321 (21%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSA-----VDGRTGAKVAIKKLYRPFQSELFAKRAYR 73 WE R + +G+GA+G V A + VA+K L +P + Sbjct: 40 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML-KPSAHLTEREALMS 98 Query: 74 ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG------ 126 EL++L ++ H N++ LL T T++ DL ++ ++ Sbjct: 99 ELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYC-----CYGDLLNFLRRKRDSFICSKT 153 Query: 127 -------------EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 + + YQ+ KG+ ++ + IHRDL N+ + KI DFG Sbjct: 154 SPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 213 Query: 174 LARQADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFK 227 LAR ++ V + + APE I N + YT D+WS G + E+ + G + + Sbjct: 214 LARDIKNDSNYVVKGNARLPVKWMAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYP 272 Query: 228 GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP-LAVN 286 G + +++K + F + +P + Sbjct: 273 GMPVDSKFYKMIK------------------------------EGFRMLSPEHAPAEMYD 302 Query: 287 LLEKMLVLDAEQRVTAGEALA 307 +++ D +R T + + Sbjct: 303 IMKTCWDADPLKRPTFKQIVQ 323 >5HLW-A nrPDB Length = 299 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 109/272 (40%), Gaps = 22/272 (8%) Query: 31 QPVGSGAYGAVCSAV---DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 + +G G +G V + A+K L R + E ++K H NV+ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGE--DRIQFLVYQMLKGLRYI 144 LL + E +V+P+M DL +++E + Q+ KG++Y+ Sbjct: 85 SLLGICLRSE-----GSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYL 139 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYRAPEVI 197 + +HRDL N ++E +K+ DFGLAR + TG + + A E + Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL 199 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 ++T D+WS G ++ E++T G + + D +++ E+ + Sbjct: 200 QT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 258 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLL 288 E+ + F+ +++ S + + Sbjct: 259 VMLKCWHPKAEM-RPSFSELVSRISAIFSTFI 289 >4LRM-A nrPDB Length = 334 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 126/288 (43%), Gaps = 23/288 (7%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKV----AIKKLYRPFQSELFAKRAYRELRLLKHMR 82 ++ ++ +GSGA+G V + G KV AIK+L R S K E ++ + Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEL-REATSPKANKEILDEAYVMASVD 79 Query: 83 HE---NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQML 138 + +V LL + T+ T MPF G L + +H+ +G + Q+ Sbjct: 80 NPGNPHVCRLLGICLTS-TVQLITQL---MPF-GCLLDYVREHKDNIGSQYLLNWCVQIA 134 Query: 139 KGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-----VTRWYRA 193 KG+ Y+ ++HRDL N+ V +KI DFGLA+ +E Y V + A Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 194 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 E IL+ + YT D+WS G + E++T G + G + + I++ P + Sbjct: 195 LESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASE-ISSILEKGERLPQPPICT 252 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + + + F ++ S +A + ++ LV+ ++R+ Sbjct: 253 IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD-PQRYLVIQGDERM 299 >3C1X-A nrPDB Length = 373 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 109/272 (40%), Gaps = 22/272 (8%) Query: 31 QPVGSGAYGAVCSAV---DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 + +G G +G V + A+K L R + E ++K H NV+ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNR-ITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGE--DRIQFLVYQMLKGLRYI 144 LL + E +V+P+M DL +++E + Q+ KG++++ Sbjct: 154 SLLGICLRSE-----GSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFL 208 Query: 145 HAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYRAPEVI 197 + +HRDL N ++E +K+ DFGLAR + TG + + A E + Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL 268 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 ++T D+WS G ++ E++T G + + D +++ E+ + Sbjct: 269 QT-QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE 327 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLL 288 E+ + F+ +++ S + + Sbjct: 328 VMLKCWHPKAEM-RPSFSELVSRISAIFSTFI 358 >5AMN-A nrPDB Length = 299 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 119/306 (38%), Gaps = 64/306 (20%) Query: 20 AWEV-RAVYRDLQPVGSGAYGAVCSAV----DGRTG-AKVAIKKLYRPFQSELFAKRAYR 73 WE R + +G G +G V A GR G VA+K L + S + Sbjct: 17 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML-KENASPSELRDLLS 75 Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK-------- 124 E +LK + H +VI L + D L L++ + L ++ + Sbjct: 76 EFNVLKQVNHPHVIKLYGACSQDGPL------LLIVEYAKYGSLRGFLRESRKVGPGYPD 129 Query: 125 ---LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 L + +Q+ +G++Y+ ++HRDL N+ V E ++KI DFGL+R E Sbjct: 130 ERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE 189 Query: 182 MT------GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQ 234 + G + +W A E + + + YT D+WS G ++ E++T G + G Sbjct: 190 DSYVKRSQGRIPVKW-MAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPG------ 241 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 + + N +K +E+ D N S L+ + Sbjct: 242 ------------------IPPERLFNLLKTGHRMERPD------NCSEEMYRLMLQCWKQ 277 Query: 295 DAEQRV 300 + ++R Sbjct: 278 EPDKRP 283 >6CTH-A nrPDB Length = 309 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 51/212 (24%), Positives = 97/212 (45%), Gaps = 19/212 (8%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 +V + + +G G +G+V + +A+KK+ R S+ K E++++ + Sbjct: 12 KVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA--SKQGIKEYASEVKIISRL 69 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK--LGEDRIQFLVYQML 138 RH+N++ L+ + + LV FM L + K L + +V + Sbjct: 70 RHKNLVKLIGWC------HERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLA 123 Query: 139 KGLRYIHA---AGIIHRDLKPGNLAVNEDCELKILDFGLARQADS----EMTGYVVTRWY 191 L Y+H ++HRD+K N+ ++ K+ DFGLAR D + T T Y Sbjct: 124 SALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGY 183 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 APE + + + ++ D++S G + E+ +G+ Sbjct: 184 MAPECLSSG-KASKESDVYSFGVVALEIASGR 214 >4Y83-A nrPDB Length = 332 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 73/309 (23%), Positives = 126/309 (40%), Gaps = 46/309 (14%) Query: 8 RSGFYR--QEVTKTAWEVRAVYRDL--QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ 63 ++G Y+ +V W++ YR++ + GA+G V A D +T ++A K + Sbjct: 54 QNGRYQIDSDVLLIPWKL--TYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQF 111 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE 123 + + RHEN+ L ET+ F + G+ L KL Sbjct: 112 KPSD-------VEIQACFRHENIAELYGAVLWGETVHLFMEAG----EGGSVLEKLESCG 160 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM- 182 + E I ++ +LKGL ++H+ +IH D+KP N+ V + ++DFGL+ Q ++ Sbjct: 161 PMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI-VFMSTKAVLVDFGLSVQMTEDVY 219 Query: 183 --TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 T Y +PEVIL ++ DI+S+G + M TG + Sbjct: 220 FPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTPPW-------------- 264 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 V+R +Y+ + + + I + SP L+E L + R Sbjct: 265 ---------VKRYPRSAYPSYLYIIHK-QAPPLEDIADDCSPGMRELIEASLERNPNHRP 314 Query: 301 TAGEALAHP 309 A + L H Sbjct: 315 RAADLLKHE 323 >2A1A-B nrPDB Length = 284 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 121/297 (40%), Gaps = 58/297 (19%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 +++++ +GSG +G V A G IK++ ++A RE++ L + H N+ Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK------YNNEKAEREVKALAKLDHVNI 66 Query: 87 IGLLDVF----------TPDETLDDFTDFYLVMPFMG-TDLGKLMKH---EKLGEDRIQF 132 + + + + + ++ M F L + ++ EKL + Sbjct: 67 VHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALE 126 Query: 133 LVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL--ARQADSEMTGYVVTRW 190 L Q+ KG+ YIH+ +I+RDLKP N+ + + ++KI DFGL + + D + T T Sbjct: 127 LFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLR 186 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 Y +PE I + Y + VD++++G I+AE++ Sbjct: 187 YMSPEQI-SSQDYGKEVDLYALGLILAELL------------------------------ 215 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 D A K +L + I LL+K+L E R E L Sbjct: 216 --HVCDTAFETSKFFTDLRDGIISDIFDKKEKT---LLQKLLSKKPEDRPNTSEILR 267 >4IDT-A nrPDB Length = 356 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 73/336 (21%), Positives = 122/336 (36%), Gaps = 72/336 (21%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 YR+EV ++R +G G++G V D +TG + A+KK+ Sbjct: 69 YREEVHWATHQLR--------LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA------ 114 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK-LGEDRI 130 EL + ++ L ++ F + G LG+L+K + L EDR Sbjct: 115 -EELMACAGLTSPRIVPLYGAVREGPWVNIFMEL-----LEGGSLGQLVKEQGCLPEDRA 168 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC-ELKILDFGLARQADSEMTGYV--- 186 + + Q L+GL Y+H+ I+H D+K N+ ++ D + DFG A + G Sbjct: 169 LYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLT 228 Query: 187 -----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 T + APEV+L VD+WS C+M M+ G + Sbjct: 229 GDYIPGTETHMAPEVVLGRS-CDAKVDVWSSCCMMLHMLNGCHPW--------------- 272 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 T ++ S+ I + +PL +++ L + RV+ Sbjct: 273 TQFFRGPLCLKIASE-------------PPPVREIPPSCAPLTAQAIQEGLRKEPIHRVS 319 Query: 302 AGEA-------------LAHPYFESLHDTEDEPQVQ 324 A E L P+ + P Q Sbjct: 320 AAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQ 355 >3PLS-A nrPDB Length = 298 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 104/285 (36%), Gaps = 51/285 (17%) Query: 31 QPVGSGAYGAVCSAVDG---RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 + +G G +G V + + AIK L R + + + RE L++ + H NV+ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQ-QVEAFLREGLLMRGLNHPNVL 85 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE--DRIQFLVYQMLKGLRYIH 145 L+ + P E L Y+ DL + ++ + + Q+ +G+ Y+ Sbjct: 86 ALIGIMLPPEGLPHVLLPYM----CHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLA 141 Query: 146 AAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--------DSEMTGYVVTRWYRAPEVI 197 +HRDL N ++E +K+ DFGLAR + +W A E + Sbjct: 142 EQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESL 200 Query: 198 LNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSD 256 + R+T D+WS G ++ E++T G ++ D D + + P E+ Sbjct: 201 QTY-RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQ 259 Query: 257 EAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 +++ D R T Sbjct: 260 V------------------------------MQQCWEADPAVRPT 274 >5U6C-A nrPDB Length = 315 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 102/265 (38%), Gaps = 25/265 (9%) Query: 9 SGFYRQEVTKTAWEV------RAVYRDLQPVGSGAYGAVCSAVDGR---TGAKVAIKKLY 59 Y Q + ++ R + + +G G +G+V + T KVA+K + Sbjct: 14 ENLYFQGSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMK 73 Query: 60 RPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGK 118 S+ + E +K H NV+ LL V + + +++PFM DL Sbjct: 74 LDNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHT 132 Query: 119 LMKHEKL-------GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILD 171 + + +L + + + G+ Y+ +HRDL N + +D + + D Sbjct: 133 YLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVAD 192 Query: 172 FGLARQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTL 225 FGL+++ S + A E + + + YT D+W+ G M E+ T G T Sbjct: 193 FGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRV-YTSKSDVWAFGVTMWEIATRGMTP 251 Query: 226 FKGSDHLDQLKEIMKVTGTPPAEFV 250 + G + + ++ E Sbjct: 252 YPGVQNHEMYDYLLHGHRLKQPEDC 276 >5TOS-A nrPDB Length = 395 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 115/302 (38%), Gaps = 44/302 (14%) Query: 26 VYRDLQPVGSGAYGAVCSA---------VDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 +R +G G +G V TG +A+KKL + + E+ Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEGFQGHREWLTEIN 123 Query: 77 LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKH----EKLGEDRI 130 L + H N++ L+ DE LV FM G+ L + + L Sbjct: 124 YLGQLSHPNLVKLIGYCLEDE------HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 131 QFLVYQMLKGLRYIHA--AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-- 186 + KGL ++H+ +I+RD+K N+ ++ D K+ DFGLAR YV Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 Query: 187 ---VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 T Y APE ++ D++S G ++ E+++GK + DH KE V Sbjct: 238 RVMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGK---RALDHNRPAKEENLVDW 293 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 P +R K L ++ + L + ++ + L + + R T Sbjct: 294 ARPYLTSKR----------KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 Query: 304 EA 305 + Sbjct: 344 QV 345 >1U59-A nrPDB Length = 287 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 58/251 (23%), Positives = 109/251 (43%), Gaps = 22/251 (8%) Query: 32 PVGSGAYGAVCSAVDG--RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G G +G+V V + VAIK L + + + + RE +++ + + ++ L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 75 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTD-LGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHA 146 + V + LVM G L K + K E++ + L++Q+ G++Y+ Sbjct: 76 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 128 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRW---YRAPEVILNW 200 +HRDL N+ + KI DFGL++ DS T +W + APE I N+ Sbjct: 129 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NF 187 Query: 201 MRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGT-PPAEFVQRLQSDEA 258 +++ D+WS G M E ++ G+ +K + + I + P E L + + Sbjct: 188 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 247 Query: 259 KNYMKGLPELE 269 ++ + Sbjct: 248 DCWIYKWEDRP 258 >5GRN-A nrPDB Length = 356 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 126/320 (39%), Gaps = 68/320 (21%) Query: 18 KTAWEV-RAVYRDLQPVGSGAYGAVCSAV-----DGRTGAKVAIKKLYRPFQSELFAKRA 71 + WE R + +GSGA+G V + KVA+K L +P + Sbjct: 38 DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKML-KPTARSSEKQAL 96 Query: 72 YRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYL---VMPFMGTDLGKLMKHEK--- 124 EL+++ H+ H N++ LL T + T++ ++ ++ + + H+K Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSM 156 Query: 125 ----------------LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELK 168 L + YQ+ +G+ ++ + +HRDL N+ + + +K Sbjct: 157 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 169 ILDFGLARQA------DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT- 221 I DFGLAR S+ + ++ +W APE I + + YT D+WS G ++ E+ + Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFSL 274 Query: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 G T + G + N +K + K D +A+ Sbjct: 275 GGTPYPGM-----------------------MVDSTFYNKIKSGYRMAKPD------HAT 305 Query: 282 PLAVNLLEKMLVLDAEQRVT 301 ++ K + E+R + Sbjct: 306 SEVYEIMVKCWNSEPEKRPS 325 >4TPT-A nrPDB Length = 303 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 51/215 (23%), Positives = 91/215 (42%), Gaps = 34/215 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G G +G TG + +K+L R E K E+++++ + H NV+ + Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIR--CDEETQKTFLTEVKVMRSLDHPNVLKFI 63 Query: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH-EKLGEDRIQFLVYQMLKGLRYIHAAG 148 V D+ L+ L+ ++ G L ++ + + + G+ Y+H+ Sbjct: 64 GVLYKDKKLN------LLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 149 IIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT-----------------------GY 185 IIHRDL N + D + + DFGL+R E Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI 220 V ++ APE++ N Y +TVDI+S G ++ E+I Sbjct: 178 VGNPYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >4PL5-B nrPDB Length = 435 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 85/323 (26%), Positives = 135/323 (41%), Gaps = 66/323 (20%) Query: 32 PVGSGAYGA-VCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGL 89 +G GA G V + VA+K++ S A RE++LL+ H NVI Sbjct: 34 VLGHGAEGTIVYKGMF--DNRDVAVKRILPECFS-----FADREVQLLRESDEHPNVIRY 86 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE---KLGEDRIQFLVYQMLKGLRYIHA 146 T D Y+ + L + ++ + LG + I L++Q GL ++H+ Sbjct: 87 FC------TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHS 139 Query: 147 AGIIHRDLKPGNLAV---NEDCELK--ILDFGLARQAD------SEMTGYVVTRWYRAPE 195 I+HRDLKP N+ + N +K I DFGL ++ S +G T + APE Sbjct: 140 LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 199 Query: 196 VILNWMRY--TQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 ++ + T TVDI+S GC+ +I+ G F G Q ++ Sbjct: 200 MLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNL-------- 250 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 D + +A L+EKM+ +D +QR +A L HP+F Sbjct: 251 -------------------DCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFW 291 Query: 313 SLHDTEDEPQVQKYDDSFDDVDR 335 SL E Q+Q + D D +++ Sbjct: 292 SL-----EKQLQFFQDVSDRIEK 309 >3I81-A nrPDB Length = 315 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 109/311 (35%), Gaps = 62/311 (19%) Query: 19 TAWEV-RAVYRDLQPVGSGAYGAVCSAVDG-----RTGAKVAIKKLYRPFQSELFAKRAY 72 WEV R + +G G++G V V +VAIK + S Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFL 69 Query: 73 RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK------- 124 E ++K +V+ LL V + + ++M M DL ++ + Sbjct: 70 NEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLRSLRPEMENNP 123 Query: 125 -LGEDRIQFLVY---QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 L + ++ ++ G+ Y++A +HRDL N V ED +KI DFG+ R Sbjct: 124 VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE 183 Query: 181 EMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQ 234 + + +PE + + + +T D+WS G ++ E+ T + ++G + Sbjct: 184 TDYYRKGGKGLLPVRWMSPESLKDGV-FTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 242 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 L+ +M+ N + L+ Sbjct: 243 LRFVMEGG------------------------------LLDKPDNCPDMLFELMRMCWQY 272 Query: 295 DAEQRVTAGEA 305 + + R + E Sbjct: 273 NPKMRPSFLEI 283 >6FER-A nrPDB Length = 309 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 56/315 (17%), Positives = 110/315 (34%), Gaps = 62/315 (19%) Query: 24 RAVYRDLQPVGSGAYGAVCSA--------------VDGRTGA--KVAIKKLYRPFQSELF 67 R + + +G G +G V +D VA+K L ++ Sbjct: 8 RKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADA-NKNA 66 Query: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---- 122 +E++++ ++ N+I LL V D+ L ++ +M DL + + Sbjct: 67 RNDFLKEIKIMSRLKDPNIIHLLAVCITDDPL------CMITEYMENGDLNQFLSRHEPP 120 Query: 123 -------EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 + ++F+ Q+ G++Y+ + +HRDL N V ++ +KI DFG++ Sbjct: 121 NSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMS 180 Query: 176 RQADSEMTGYVVTRW-----YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSD 230 R S + R + + E IL ++T D+W+ G + E T F Sbjct: 181 RNLYSGDYYRIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT----FCQEQ 235 Query: 231 HLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEK 290 QL +N + + ++ + L+ Sbjct: 236 PYSQLS-----------------DEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLS 278 Query: 291 MLVLDAEQRVTAGEA 305 D + R + E Sbjct: 279 CWRRDTKNRPSFQEI 293 >2RIO-A nrPDB Length = 434 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 74/319 (23%), Positives = 132/319 (41%), Gaps = 74/319 (23%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGL 89 + +G G+ G V G VA+K++ F A E++LL H NVI Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDI-----ALMEIKLLTESDDHPNVIRY 74 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ--------FLVYQMLKGL 141 T D L Y+ + +L L++ + + ++ ++ L+ Q+ G+ Sbjct: 75 YCSETTDRFL------YIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGV 128 Query: 142 RYIHAAGIIHRDLKPGNLAVN-------------EDCELKILDFGLARQADSEMTGY--- 185 ++H+ IIHRDLKP N+ V+ E+ + I DFGL ++ DS + + Sbjct: 129 AHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN 188 Query: 186 ----VVTRWYRAPEV------ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQ 234 T +RAPE+ + R T+++DI+S+GC+ +++ GK F Sbjct: 189 LNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD------ 242 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 + N ++G+ L++ + A +L+ +M+ Sbjct: 243 -------------------KYSRESNIIRGIFSLDEMKCLHDRSLI-AEATDLISQMIDH 282 Query: 295 DAEQRVTAGEALAHPYFES 313 D +R TA + L HP F Sbjct: 283 DPLKRPTAMKVLRHPLFWP 301 >6J5U-C nrPDB Length = 426 Score = 177 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 119/323 (36%), Gaps = 46/323 (14%) Query: 4 PPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRT---------GAKVA 54 P F E+ +R +G G +G V +T G VA Sbjct: 67 SSPNLKAFTFNELKNATKN----FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVA 122 Query: 55 IKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-- 112 +K+L + K E+ L + H N++ L+ E + LV FM Sbjct: 123 VKQLK--PEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGE------NRLLVYEFMPK 174 Query: 113 GTDLGKLMKH--EKLGEDRIQFLVYQMLKGLRYIHAAG--IIHRDLKPGNLAVNEDCELK 168 G+ L + + L + KGL ++H A +I+RD K N+ ++ D K Sbjct: 175 GSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAK 234 Query: 169 ILDFGLARQADSEMTGYV-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 + DFGLA+ + +V T Y APE + R T D++S G ++ E+I+G+ Sbjct: 235 LSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATG-RLTAKSDVYSFGVVLLELISGR 293 Query: 224 TLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL 283 S+ ++ + + + K ++ K + Sbjct: 294 RAMDNSNGGNEYSLV-------------DWATPYLGDKRKLFRIMDTKLGGQYPQKGAFT 340 Query: 284 AVNLLEKMLVLDAEQRVTAGEAL 306 A NL + L DA+ R E L Sbjct: 341 AANLALQCLNPDAKLRPKMSEVL 363 >2OZO-A nrPDB Length = 613 Score = 177 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 109/251 (43%), Gaps = 22/251 (8%) Query: 32 PVGSGAYGAVCSAVDG--RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 +G G +G+V V + VAIK L + + + + RE +++ + + ++ L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRL 401 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTD-LGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHA 146 + V + LVM G L K + K E++ + L++Q+ G++Y+ Sbjct: 402 IGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRW---YRAPEVILNW 200 +HR+L N+ + KI DFGL++ DS T +W + APE I N+ Sbjct: 455 KNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NF 513 Query: 201 MRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGT-PPAEFVQRLQSDEA 258 +++ D+WS G M E ++ G+ +K + + I + P E L + + Sbjct: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 Query: 259 KNYMKGLPELE 269 ++ + Sbjct: 574 DCWIYKWEDRP 584 >5FM2-A nrPDB Length = 355 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 127/348 (36%), Gaps = 88/348 (25%) Query: 2 SSPPPARSGFYRQE--VTKTAWEV---------RAVYRDLQPVGSGAYGAVCSAV----D 46 SS R E V+ A+++ R + +G G +G V A Sbjct: 30 SSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLK 89 Query: 47 GRTG-AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDF 105 GR G VA+K L + S + E +LK + H +VI L + D L Sbjct: 90 GRAGYTTVAVKML-KENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPL------ 142 Query: 106 YLVMPFMG-TDLGKLMKHEK-------------------------LGEDRIQFLVYQMLK 139 L++ + L ++ + L + +Q+ + Sbjct: 143 LLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQ 202 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT------GYVVTRWYRA 193 G++Y+ ++HRDL N+ V E ++KI DFGL+R E + G + +W A Sbjct: 203 GMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW-MA 261 Query: 194 PEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 E + + + YT D+WS G ++ E++T G + G Sbjct: 262 IESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPG------------------------ 296 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 + + N +K +E+ D N S L+ + + ++R Sbjct: 297 IPPERLFNLLKTGHRMERPD------NCSEEMYRLMLQCWKQEPDKRP 338 >3UIU-A nrPDB Length = 306 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 124/310 (40%), Gaps = 71/310 (22%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 +++++ +GSG +G V A G I+++ ++A RE++ L + H N+ Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK------YNNEKAEREVKALAKLDHVNI 67 Query: 87 IGLLDVF--------TPDETLDDFT---------------DFYLVMPFMG-TDLGKLMKH 122 + + T D++L+ ++ M F L + ++ Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 127 Query: 123 ---EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL--ARQ 177 EKL + L Q+ KG+ YIH+ +IHRDLKP N+ + + ++KI DFGL + + Sbjct: 128 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK 187 Query: 178 ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 D + T T Y +PE I + Y + VD++++G I+AE++ Sbjct: 188 NDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL----------------- 229 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 D A K +L + I LL+K+L E Sbjct: 230 ---------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKT---LLQKLLSKKPE 271 Query: 298 QRVTAGEALA 307 R E L Sbjct: 272 DRPNTSEILR 281 >6HV0-A nrPDB Length = 416 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 84/323 (26%), Positives = 135/323 (41%), Gaps = 66/323 (20%) Query: 32 PVGSGAYGA-VCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGL 89 +G GA G V + VA+K++ S A RE++LL+ H NVI Sbjct: 15 VLGHGAEGTIVYRGMF--DNRDVAVKRILPECFS-----FADREVQLLRESDEHPNVIRY 67 Query: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE---KLGEDRIQFLVYQMLKGLRYIHA 146 T D Y+ + L + ++ + LG + I L+ Q GL ++H+ Sbjct: 68 FC------TEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHS 120 Query: 147 AGIIHRDLKPGNLAV---NEDCELK--ILDFGLARQAD------SEMTGYVVTRWYRAPE 195 I+HRDLKP N+ + N ++K I DFGL ++ S +G T + APE Sbjct: 121 LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPE 180 Query: 196 VILNWMR--YTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 ++ + T TVDI+S GC+ +I+ G F G Q ++ Sbjct: 181 MLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSL-------- 231 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 D + +A L+EKM+ +D ++R +A L HP+F Sbjct: 232 -------------------DCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFW 272 Query: 313 SLHDTEDEPQVQKYDDSFDDVDR 335 SL E Q+Q + D D +++ Sbjct: 273 SL-----EKQLQFFQDVSDRIEK 290 >2BUJ-A nrPDB Length = 317 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 126/329 (38%), Gaps = 60/329 (18%) Query: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66 R Y Q Y +Q +G G + V G A+K++ Q + Sbjct: 13 GRENLYFQGHMVIIDN--KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQD- 69 Query: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLM---- 120 + A RE + + H N++ L+ + + +L++PF GT ++ Sbjct: 70 -REEAQREADMHRLFNHPNILRLVAYCLRER--GAKHEAWLLLPFFKRGTLWNEIERLKD 126 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 K L ED+I +L+ + +GL IHA G HRDLKP N+ + ++ + ++D G QA Sbjct: 127 KGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACI 186 Query: 181 EMTGY------------VVTRWYRAPEV--ILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226 + G T YRAPE+ + + + D+WS+GC++ M+ G+ + Sbjct: 187 HVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 Query: 227 KGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN 286 + + + +L ++ + L + Sbjct: 247 D---------MVFQKGDSVALAVQNQLSIPQSPRHSSALWQ------------------- 278 Query: 287 LLEKMLVLDAEQRVTAG------EALAHP 309 LL M+ +D QR EAL P Sbjct: 279 LLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >5WNL-A nrPDB Length = 342 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 121/346 (34%), Gaps = 55/346 (15%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + VGSG +G V +AIK + E + ++ + ++ + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 91 DVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH--AA 147 + LVM +M L KL+ E L D +V++ G+ ++H + Sbjct: 86 GICQEP--------VGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSP 137 Query: 148 GIIHRDLKPGNLAVNEDCELKILDFGLAR------QADSEMTGYVVTRWYRAPEVILNWM 201 ++H +LKP N+ ++ +KI DFGLA+ D M G T Y PE I Sbjct: 138 PLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKS 197 Query: 202 R-YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKN 260 R + D++S ++ ++T K F +D + L +MKV E + Sbjct: 198 RLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRPELPPICRPR---- 251 Query: 261 YMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 A + L+++ D + R T E +E E Sbjct: 252 -----------------PRACASLIGLMQRCWHADPQVRPTFQEI----------TSETE 284 Query: 321 PQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGARVSKETP 366 +K D+ D+ E + K + + P Sbjct: 285 DLCEKPDEEVKDLAHEPGEKSSLESK----SEARPESSRLKRASAP 326 >3Q4U-A nrPDB Length = 301 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 116/308 (37%), Gaps = 61/308 (19%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK--HMRHEN 85 L+ VG G YG V G VA+K S K +RE L +RHEN Sbjct: 11 TLLECVGKGRYGEVWRG--SWQGENVAVKIF-----SSRDEKSWFRETELYNTVMLRHEN 63 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQMLKGLRYI 144 ++G + + + T +L+ + L ++ L +V + GL ++ Sbjct: 64 ILGFIA--SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHL 121 Query: 145 H--------AAGIIHRDLKPGNLAVNEDCELKILDFGLA-------RQADSEMTGYVVTR 189 H I HRDLK N+ V ++ + I D GLA Q D V T+ Sbjct: 122 HIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 190 WYRAPEVILNWMRYT-----QTVDIWSVGCIMAEMITG----------KTLFKGSDHLDQ 234 Y APEV+ ++ + VDIW+ G ++ E+ K F Sbjct: 182 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV----- 236 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 V P E ++++ + + P + + F+ + LA L+++ Sbjct: 237 ------VPNDPSFEDMRKVVCVDQQR-----PNIPNRWFSD--PTLTSLAK-LMKECWYQ 282 Query: 295 DAEQRVTA 302 + R+TA Sbjct: 283 NPSARLTA 290 >5LPZ-A nrPDB Length = 332 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 121/295 (41%), Gaps = 38/295 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + + +GSG +G V A+ + G+ VAIKKL S + E+ + ++H N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNL 75 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK-----LGEDRIQFLVYQMLKG 140 + LL + + LV FM L ++ K L + + +G Sbjct: 76 VPLLGYCKVGD------ERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 141 LRYIHAA---GIIHRDLKPGNLAVNEDCELKILDFGLAR---QADSEM--TGYVVTRWYR 192 L ++H IIHRD+K N+ ++E+ E ++ DFG+AR D+ + + T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 PE ++ R + D++S G ++ E++TGK D D + G R Sbjct: 190 PPEYYQSF-RCSTKGDVYSYGVVLLELLTGKRPTDSPDFGD-----NNLVGWVKQHAKLR 243 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + MK P LE + + + L A +R T + +A Sbjct: 244 ISDVFDPELMKEDPALEIELLQHLKVAVA---------CLDDRAWRRPTMVQVMA 289 >5LPV-A nrPDB Length = 296 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 119/295 (40%), Gaps = 38/295 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + + +GSG +G V A+ + G+ VAIKKL S + E+ + ++H N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHV--SGQGDREFMAEMETIGKIKHRNL 75 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK-----LGEDRIQFLVYQMLKG 140 + LL + + LV FM L ++ K L + + +G Sbjct: 76 VPLLGYCKVGD------ERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARG 129 Query: 141 LRYIHAA---GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT-----GYVVTRWYR 192 L ++H IIHRD+K N+ ++E+ E ++ DFG+AR + T T Y Sbjct: 130 LAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYV 189 Query: 193 APEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQR 252 PE ++ R + D++S G ++ E++TGK D D + G R Sbjct: 190 PPEYYQSF-RCSTKGDVYSYGVVLLELLTGKRPTDSPDFGD-----NNLVGWVKQHAKLR 243 Query: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + MK P LE + + + L A +R T + +A Sbjct: 244 ISDVFDPELMKEDPALEIELLQHLKVAVA---------CLDDRAWRRPTMVQVMA 289 >3QD2-B nrPDB Length = 332 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 124/335 (37%), Gaps = 89/335 (26%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 + +Q +G G +G V A + AIK++ P EL ++ RE++ L + H + Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLP-NRELAREKVMREVKALAKLEHPGI 66 Query: 87 IGLLDVF--TPDETLDDFTD---------------------------------------- 104 + + + TP E + D Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 105 ---------FYLVMPFM-GTDLGKLMKHEKLGEDR----IQFLVYQMLKGLRYIHAAGII 150 Y+ M +L M EDR + Q+ + + ++H+ G++ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 151 HRDLKPGNLAVNEDCELKILDFGLARQADSE---------------MTGYVVTRWYRAPE 195 HRDLKP N+ D +K+ DFGL D + TG V T+ Y +PE Sbjct: 187 HRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPE 246 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG-TPPAEFVQRLQ 254 I Y+ VDI+S+G I+ E++ + S +++++ I V P F Q+ Sbjct: 247 QIHGN-NYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNLKFPLLFTQKYP 300 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE 289 + + +D S P A +++E Sbjct: 301 QE----------HMMVQDMLSPSPTERPEATDIIE 325 >4F0G-A nrPDB Length = 287 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 114/287 (39%), Gaps = 53/287 (18%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKL---YRPFQSELFAK--RAYRELRLLKHMRHEN 85 + +G G +G V + + VAIK L ++E+ K RE+ ++ ++ H N Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLM-KHEKLGEDRIQFLVYQMLKGLR 142 ++ L + +VM F G +L+ K + L+ + G+ Sbjct: 85 IVKLYGLMHNPPR--------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 143 YIHAAG--IIHRDLKPGNLA---VNEDCEL--KILDFGLARQADSEMTGYVVTRWYRAPE 195 Y+ I+HRDL+ N+ ++E+ + K+ DFGL++Q+ ++G + + APE Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPE 196 Query: 196 VI-LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ-LKEIMKVTGTPPAEFVQRL 253 I YT+ D +S I+ ++TG+ F + +++ G P Sbjct: 197 TIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRP------- 249 Query: 254 QSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 +I + P N++E D ++R Sbjct: 250 ---------------------TIPEDCPPRLRNVIELCWSGDPKKRP 275 >4G3E-A nrPDB Length = 352 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 61/225 (27%), Positives = 94/225 (41%), Gaps = 31/225 (13%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 YR+EV + R VG G++G V D +TG + A+KK+ Sbjct: 69 YREEVHWMTHQPR--------VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR------- 113 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-EKLGEDRI 130 EL + ++ L ++ F + G LG+L+K L EDR Sbjct: 114 VEELVACAGLSSPRIVPLYGAVREGPWVNIFMEL-----LEGGSLGQLIKQMGCLPEDRA 168 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC-ELKILDFG--LARQADSEMTGYV- 186 + + Q L+GL Y+H I+H D+K N+ ++ D + DFG L Q D + Sbjct: 169 LYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLT 228 Query: 187 -----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226 T + APEV++ VDIWS C+M M+ G + Sbjct: 229 GDYIPGTETHMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNGCHPW 272 >3ZZW-A nrPDB Length = 289 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 103/267 (38%), Gaps = 25/267 (9%) Query: 28 RDLQPVGSGAYGAVCSAV-----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 R ++ +G +G V G VAIK L + L + E L ++ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPL-REEFRHEAMLRARLQ 70 Query: 83 HENVIGLLDVFTPDETLDDFTDFY--------LVMPF----MGTDLGKLMKHEKLGEDRI 130 H NV+ LL V T D+ L + LVM +G+ L Sbjct: 71 HPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDF 130 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-----MTGY 185 LV Q+ G+ Y+ + ++H+DL N+ V + +KI D GL R+ + + Sbjct: 131 VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNS 190 Query: 186 VVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGT 244 ++ + APE I+ + +++ DIWS G ++ E+ + G + G + D ++ I Sbjct: 191 LLPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVL 249 Query: 245 PPAEFVQRLQSDEAKNYMKGLPELEKK 271 P + P + Sbjct: 250 PCPDDCPAWVYALMIECWNEFPSRRPR 276 >2PMN-X nrPDB Length = 348 Score = 167 bits (423), Expect = 8e-42, Method: Composition-based stats. Identities = 57/319 (17%), Positives = 120/319 (37%), Gaps = 51/319 (15%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFA---------------KRA 71 YR ++ + G + + + A+KK + + Sbjct: 33 YRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDF 90 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK------- 124 EL+++ +++E T + + ++ + Y++ +M D ++K ++ Sbjct: 91 KNELQIITDIKNE------YCLTCEGIITNYDEVYIIYEYMEND--SILKFDEYFFVLDK 142 Query: 125 -----LGEDRIQFLVYQMLKGLRYIH-AAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 + I+ ++ +L YIH I HRD+KP N+ ++++ +K+ DFG + Sbjct: 143 NYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYM 202 Query: 179 -DSEMTGYVVTRWYRAPEVILNWMRY-TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLK 236 D ++ G T + PE N Y VDIWS+G + M F Sbjct: 203 VDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF---------S 253 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDA 296 + + + ++ +N+ L L K S ++ L+ L + Sbjct: 254 LKISLVELFNNIRTKNIEYPLDRNHF--LYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNP 311 Query: 297 EQRVTAGEALAHPYFESLH 315 +R+T+ +AL H + + Sbjct: 312 AERITSEDALKHEWLADTN 330 >3SOC-A nrPDB Length = 322 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 128/322 (39%), Gaps = 44/322 (13%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q + EV+A G +G V A VA+K P Sbjct: 10 SGVDLGTENLYFQSMPLQLLEVKA---------RGRFGCVWKAQ--LLNEYVAVKIF--P 56 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLM 120 Q + + Y E+ L M+HEN++ + ++D D +L+ F L + Sbjct: 57 IQDKQSWQNEY-EVYSLPGMKHENILQFIGAEKRGTSVD--VDLWLITAFHEKGSLSDFL 113 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIHA----------AGIIHRDLKPGNLAVNEDCELKIL 170 K + + + + M +GL Y+H I HRD+K N+ + + I Sbjct: 114 KANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIA 173 Query: 171 DFGLARQAD-----SEMTGYVVTRWYRAPEVILNWMRYTQ----TVDIWSVGCIMAEMIT 221 DFGLA + + + G V TR Y APEV+ + + + +D++++G ++ E+ + Sbjct: 174 DFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 Query: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 T G L ++ P E +Q + + K + L + +K Sbjct: 234 RCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPV--LRDYWQK------HAGM 285 Query: 282 PLAVNLLEKMLVLDAEQRVTAG 303 + +E+ DAE R++AG Sbjct: 286 AMLCETIEECWDHDAEARLSAG 307 >3AOX-A nrPDB Length = 344 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 99/280 (35%), Gaps = 32/280 (11%) Query: 24 RAVYRDLQPVGSGAYGAVCSAV-----DGRTGAKVAIKKLYRPFQSELFAKRAYRELRLL 78 R ++ +G GA+G V + + +VA+K L SE E ++ Sbjct: 46 RKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALII 104 Query: 79 KHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK--------LGEDR 129 H+N++ + V ++++ M G DL ++ + L Sbjct: 105 SKFNHQNIVRCIGVSLQSLPR------FILLELMAGGDLKSFLRETRPRPSQPSSLAMLD 158 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC---ELKILDFGLARQADSEMTGYV 186 + + + G +Y+ IHRD+ N + KI DFG+AR Sbjct: 159 LLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRK 218 Query: 187 V-----TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK 240 + PE + + +T D WS G ++ E+ + G + + + L+ + Sbjct: 219 GGCAMLPVKWMPPEAFMEGI-FTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS 277 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNA 280 P + + PE ++ +FA IL Sbjct: 278 GGRMDPPKNCPGPVYRIMTQCWQHQPE-DRPNFAIILERI 316 >5TE0-A nrPDB Length = 347 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 112/296 (37%), Gaps = 59/296 (19%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGL 89 + + G + V G K A+K+++ + +L + RE+++++ + H+N++G Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCK--REIQIMRDLSGHKNIVGY 81 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE---KLGEDRIQFLVYQMLKGLRYIH 145 +D + + D + ++M F G + LM E+ + + + + +H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 146 AAG--IIHRDLKPGNLAVNEDCELKILDFGLARQ------------ADSEMTGYVVTRWY 191 IIHRDLK N+ +++ + DFG A + E+ Y T Y Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT-TLSY 200 Query: 192 RAPEV--ILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 RAPE+ + + T DIW++GC++ ++ F G + I T P Sbjct: 201 RAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQV----AICDGNFTIPDN- 254 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 + S L+ ML D ++R + Sbjct: 255 ----------------------------SRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >3MDY-A nrPDB Length = 337 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 108/296 (36%), Gaps = 37/296 (12%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI 87 + ++ +G G YG V G KVA+K + ++ F + E+ MRHEN++ Sbjct: 40 QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRET---EIYQTVLMRHENIL 94 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH- 145 G + +T YL+ + L +K L + L Y + GL ++H Sbjct: 95 GFIAADIKGT--GSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHT 152 Query: 146 -------AAGIIHRDLKPGNLAVNEDCELKILDFGLA-------RQADSEMTGYVVTRWY 191 I HRDLK N+ V ++ I D GLA + D V T+ Y Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRY 212 Query: 192 RAPEVI---LNWMRYTQT--VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 PEV+ LN + D++S G I+ E+ G QL V P Sbjct: 213 MPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCV-SGGIVEEYQLPYHDLVPSDPS 271 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 E ++ + K P D L+ + + R+TA Sbjct: 272 YEDMREIVC--IKKLRPSFPNRWSSD------ECLRQMGKLMTECWAHNPASRLTA 319 >4JLC-A nrPDB Length = 657 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 97/230 (42%), Gaps = 23/230 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA V +TG A+K + RE +LK + H+N++ L + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 74 Query: 93 FTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAA 147 E L+M F L +++ L E ++ ++ G+ ++ Sbjct: 75 ----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 130 Query: 148 GIIHRDLKPGNLA--VNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL--- 198 GI+HRD+KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 131 GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 190 Query: 199 ----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + +Y TVD+WSVG TG F+ + + KE+M T Sbjct: 191 LRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 240 >4FL3-A nrPDB Length = 635 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 105/282 (37%), Gaps = 51/282 (18%) Query: 31 QPVGSGAYGAVCSAVD--GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 + +GSG +G V + VA+K L E +++ + + ++ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 89 LLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 ++ + + + LVM +G L ++ + + I LV+Q+ G++Y+ Sbjct: 435 MIGICEAESWM-------LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQA-------DSEMTGYVVTRWYRAPEVILN 199 + +HRDL N+ + KI DFGL++ ++ G +WY APE I N Sbjct: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-N 545 Query: 200 WMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + +++ D+WS G +M E + G+ ++G + Sbjct: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM--------------------- 584 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 LEK + +L+ D E R Sbjct: 585 ---------LEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 617 >4EUU-A nrPDB Length = 319 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 23/230 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA V +TG AIK + RE +LK + H+N++ L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 75 Query: 93 FTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAA 147 E L+M F L +++ L E ++ ++ G+ ++ Sbjct: 76 ----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 148 GIIHRDLKPGNLA--VNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL--- 198 GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 199 ----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + +Y TVD+WS+G TG F+ + + KE+M T Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 241 >3G2F-A nrPDB Length = 336 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 76/310 (24%), Positives = 118/310 (38%), Gaps = 46/310 (14%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK--HMR 82 + L+ +G G YGAV VA+K S + E + + M Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVF-----SFANRQNFINEKNIYRVPLME 65 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 H+N+ + V T D ++ LVM + L K + L + + +GL Sbjct: 66 HDNIARFI-VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGL 124 Query: 142 RYIH---------AAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-----------DSE 181 Y+H I HRDL N+ V D I DFGL+ + D+ Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 182 MTGYVVTRWYRAPEVILNWMRYT------QTVDIWSVGCIMAEMITGKT-LFKGSDHLD- 233 V T Y APEV+ + + VD++++G I E+ T LF G + Sbjct: 185 AISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEY 244 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 Q+ +V P E +Q L S E + PE K++ ++ + +E Sbjct: 245 QMAFQTEVGNHPTFEDMQVLVSREKQR--PKFPEAWKENSLAVRS-----LKETIEDCWD 297 Query: 294 LDAEQRVTAG 303 DAE R+TA Sbjct: 298 QDAEARLTAQ 307 >5WNO-A nrPDB Length = 330 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 119/314 (37%), Gaps = 33/314 (10%) Query: 28 RDLQPVGSGAYGAVCSAVD-----GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 + + +G+GA+G V + + VAIK + E + +R Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ---TDQSQTDEMLEEATNMFRLR 81 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL-MKHEKLGEDRIQFLVYQMLKGL 141 H+N++ ++ D+ L T + +G L + E LG YQ+ G+ Sbjct: 82 HDNLLKIIGFCMHDDGLKIVT----IYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGM 137 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAPE 195 +Y+ ++HRDL N+ V + ++I DFGL++ + +G V +W A E Sbjct: 138 QYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW-LAIE 196 Query: 196 VILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254 I + YT D+W+ G E+IT G++ ++G D + +K Sbjct: 197 -IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMS-TDSIHNFLKDGNRLSQ--PPNCS 252 Query: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLE--KMLVLDAEQ----RVTAGEALAH 308 D + ++ K + ++ + ++ + ++A E Sbjct: 253 QDLYQELLRCWMADPKSRPG--FEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQT 310 Query: 309 PYFESLHDTEDEPQ 322 + D +PQ Sbjct: 311 ERIREMFDGNIDPQ 324 >4F9B-A nrPDB Length = 361 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 79/376 (21%), Positives = 141/376 (37%), Gaps = 78/376 (20%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAV---DGRTGAKVAIKK 57 ++ Y + ++ V++ +G G + +V A K+A+K Sbjct: 2 LAGVKKDIEKLY-----EAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKH 56 Query: 58 LYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTD 115 L R EL+ L +NV+G+ F ++ + MP++ Sbjct: 57 LI----PTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKND------HVVIAMPYLEHES 106 Query: 116 LGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGL 174 ++ E ++ + + K L+ IH GI+HRD+KP N N + ++DFGL Sbjct: 107 FLDILNSLSFQE--VREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGL 164 Query: 175 ARQADS-------------------------------EMTGYVVTRWYRAPEVILNWMRY 203 A+ ++ T +RAPEV+ Sbjct: 165 AQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQ 224 Query: 204 TQTVDIWSVGCIMAEMITGKTLFK-GSDHLDQLKEIMKVTGT--------------PPAE 248 T +D+WS G I +++G+ F SD L L +IM + G+ ++ Sbjct: 225 TTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSK 284 Query: 249 FVQRLQSDEAKNYMKGLPELEKKDFASI---------LTNASPLAVNLLEKMLVLDAEQR 299 V + ++G+ K + I A +LL+K+L L+ R Sbjct: 285 EVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASR 344 Query: 300 VTAGEALAHPYFESLH 315 +TA EAL HP+F+ + Sbjct: 345 ITAEEALLHPFFKDMS 360 >4EUT-A nrPDB Length = 396 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 23/230 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA V +TG AIK + RE +LK + H+N++ L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 75 Query: 93 FTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAA 147 E L+M F L +++ L E ++ ++ G+ ++ Sbjct: 76 ----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 131 Query: 148 GIIHRDLKPGNLA--VNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL--- 198 GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 132 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 191 Query: 199 ----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + +Y TVD+WS+G TG F+ + + KE+M T Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 241 >5C26-A nrPDB Length = 299 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 105/282 (37%), Gaps = 51/282 (18%) Query: 31 QPVGSGAYGAVCSAVD--GRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 + +GSG +G V + VA+K L E +++ + + ++ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 89 LLDVFTPDETLDDFTDFYLVMPF--MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 ++ + + + LVM +G L ++ + + I LV+Q+ G++Y+ Sbjct: 93 MIGICEAESWM-------LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 145 Query: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQA-------DSEMTGYVVTRWYRAPEVILN 199 + +HRDL N+ + KI DFGL++ ++ G +WY APE I N Sbjct: 146 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-N 203 Query: 200 WMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 + +++ D+WS G +M E + G+ ++G + Sbjct: 204 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM--------------------- 242 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 LEK + +L+ D E R Sbjct: 243 ---------LEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 275 >3UIM-A nrPDB Length = 326 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 51/215 (23%), Positives = 94/215 (43%), Gaps = 22/215 (10%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHE 84 + + +G G +G V G VA+K+L + +++ + E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRL-KEERTQGGELQFQTEVEMISMAVHR 87 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK-----LGEDRIQFLVYQML 138 N++ L T+ LV P+M + ++ L + Q + Sbjct: 88 NLLRLRGFCMTP------TERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSA 141 Query: 139 KGLRYIHAA---GIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWY 191 +GL Y+H IIHRD+K N+ ++E+ E + DFGLA+ D + T T + Sbjct: 142 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGH 201 Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLF 226 APE + ++ D++ G ++ E+ITG+ F Sbjct: 202 IAPEYLSTGKS-SEKTDVFGYGVMLLELITGQRAF 235 >1PY5-A nrPDB Length = 326 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 117/295 (39%), Gaps = 41/295 (13%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLK--HMRHENVIG 88 + +G G +G V G +VA+K S + +RE + + +RHEN++G Sbjct: 35 ESIGKGRFGEVWRGKWR--GEEVAVKIF-----SSREERSWFREAEIYQTVMLRHENILG 87 Query: 89 LLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH-- 145 + D +T +LV + L + + + + L GL ++H Sbjct: 88 FIAADNKDN--GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHME 145 Query: 146 ------AAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTG-------YVVTRWYR 192 I HRDLK N+ V ++ I D GLA + DS V T+ Y Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 193 APEVILNWMR-----YTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 APEV+ + + + DI+++G + E+ ++ G QL V P Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSV 264 Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 E ++++ ++ K P + + + S A + ++ + + R+TA Sbjct: 265 EEMRKVVCEQ-----KLRPNIPNR-WQSC--EALRVMAKIMRECWYANGAARLTA 311 >5IKW-A nrPDB Length = 310 Score = 160 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 108/302 (35%), Gaps = 58/302 (19%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR- 82 R + + G + V G + A+K++Y +L + RE+ ++K + Sbjct: 13 RHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCK--REITIMKELSG 69 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKH--EKLGEDRIQFLVYQML 138 H+N++G LD + D+ + ++M + G + ++ K E + + Sbjct: 70 HKNIVGYLD-CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTC 128 Query: 139 KGLRYIHAAG--IIHRDLKPGNLAVNEDCELKILDFGLAR-----------QADSEMTGY 185 + + +H IIHRDLK N+ +N+ + DFG A E Sbjct: 129 EAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKK 188 Query: 186 VVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 T YRAPE+I T DIW++GC++ ++ F G + I Sbjct: 189 YTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQV----AICDGNF 243 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 T P + Y + + L+ ML D E R Sbjct: 244 TIP----------DNSRYSRNIH-------------------CLIRFMLEPDPEHRPDIF 274 Query: 304 EA 305 + Sbjct: 275 QV 276 >6O8B-A nrPDB Length = 665 Score = 160 bits (405), Expect = 8e-40, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 23/230 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA V +TG AIK + RE +LK + H+N++ L + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 81 Query: 93 FTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAA 147 E L+M F L +++ L E ++ ++ G+ ++ Sbjct: 82 ----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 137 Query: 148 GIIHRDLKPGNLA--VNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL--- 198 GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 138 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAV 197 Query: 199 ----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + +Y TVD+WS+G TG F+ + + KE+M T Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 247 >6NT9-A nrPDB Length = 742 Score = 160 bits (405), Expect = 9e-40, Method: Composition-based stats. Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 23/230 (10%) Query: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDV 92 +G GA V +TG AIK + RE +LK + H+N++ L + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 73 Query: 93 FTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE----KLGEDRIQFLVYQMLKGLRYIHAA 147 E L+M F L +++ L E ++ ++ G+ ++ Sbjct: 74 ----EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN 129 Query: 148 GIIHRDLKPGNLA--VNEDCE--LKILDFGLARQA--DSEMTGYVVTRWYRAPEVIL--- 198 GI+HR++KPGN+ + ED + K+ DFG AR+ D + T Y P++ Sbjct: 130 GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAV 189 Query: 199 ----NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244 + +Y TVD+WS+G TG F+ + + KE+M T Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIT 239 >2QKW-B nrPDB Length = 321 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 122/307 (39%), Gaps = 38/307 (12%) Query: 12 YRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71 YR + E + +G G +G V V R GAKVA+K R +S + Sbjct: 27 YRVPLV-DLEEATNNFDHKFLIGHGVFGKVYKGV-LRDGAKVALK--RRTPESSQGIEEF 82 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG------TDLGKLMKHEKL 125 E+ L RH +++ L+ D+ + L+ +M G + + Sbjct: 83 ETEIETLSFCRHPHLVSLIGFC------DERNEMILIYKYMENGNLKRHLYGSDLPTMSM 136 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY 185 ++ + +GL Y+H IIHRD+K N+ ++E+ KI DFG++++ + Sbjct: 137 SWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTH 196 Query: 186 V-----VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 + T Y PE + R T+ D++S G ++ E++ ++ Sbjct: 197 LSTVVKGTLGYIDPEYFIKG-RLTEKSDVYSFGVVLFEVLCARS---------------A 240 Query: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFAS-ILTNASPLAVNLLEKMLVLDAEQR 299 + + P E V + + L ++ + A I + + K L L +E R Sbjct: 241 IVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDR 300 Query: 300 VTAGEAL 306 + G+ L Sbjct: 301 PSMGDVL 307 >3MY0-A nrPDB Length = 305 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 111/307 (36%), Gaps = 61/307 (19%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH--MRHENV 86 ++ VG G YG V + G VA+K S + +RE + +RH+N+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIF-----SSRDEQSWFRETEIYNTVLLRHDNI 64 Query: 87 IGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIH 145 +G + + + + T +L+ + L ++ + L L GL ++H Sbjct: 65 LGFIA--SDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLH 122 Query: 146 --------AAGIIHRDLKPGNLAVNEDCELKILDFGLAR-------QADSEMTGYVVTRW 190 I HRD K N+ V + + I D GLA D V T+ Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 191 YRAPEVILNWMRYT-----QTVDIWSVGCIMAEMITG----------KTLFKGSDHLDQL 235 Y APEV+ +R + DIW+ G ++ E+ + F Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDV------ 236 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 V P E ++++ + + P + + A S LA ++ + + Sbjct: 237 -----VPNDPSFEDMKKVVCVDQQT-----PTIPNRLAAD--PVLSGLAQ-MMRECWYPN 283 Query: 296 AEQRVTA 302 R+TA Sbjct: 284 PSARLTA 290 >5XD6-A nrPDB Length = 305 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 54/223 (24%), Positives = 92/223 (41%), Gaps = 30/223 (13%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 ++ Y +G G+YG V + ++G AIKKL Q + + ++ ++ + Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPD---QEFLAQVSMVSRL 74 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK----------LGEDRI 130 R ENV+ LL D L + L ++ K L + Sbjct: 75 RQENVVALLGYCV------DGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQR 128 Query: 131 QFLVYQMLKGLRYIHAA---GIIHRDLKPGNLAVNEDCELKILDFGLARQADS-----EM 182 + +GL Y+H +IHRD+K N+ + +D KI DF L+ QA Sbjct: 129 VKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHS 188 Query: 183 TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL 225 T + T Y APE + + D++S G ++ E++TG+ Sbjct: 189 TRVLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKP 230 >4M66-A nrPDB Length = 325 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 116/296 (39%), Gaps = 44/296 (14%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R + L+ VG G +G V A VA+K + +K+ E++ + ++R+ Sbjct: 19 REELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN--------SKKISWEVKAMVNLRN 70 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 ENV+ LL V T D D + LV FM G+ G L + L+ +++ G+ Sbjct: 71 ENVLLLLGV-TEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGM 129 Query: 142 RYIHAAG--IIHRDLKPGNLAVNEDCELKILDFGLAR---------QADSEMTGYVVTRW 190 Y+H+ ++HRDLKP N+ ++ + K+ DFGL+ + S T Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 191 YRAPEVILN-WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249 Y PE++ ++ ++ D++S G ++ ++ G+ E++ T Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE-----------AELVDKTSLIRETV 238 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 R G PE L+ +E R + + Sbjct: 239 CDRQSRPPLTELPPGSPETPGL----------EKLKELMIHCWGSQSENRPSFQDC 284 >6DC0-A nrPDB Length = 292 Score = 157 bits (397), Expect = 8e-39, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 108/281 (38%), Gaps = 51/281 (18%) Query: 41 VCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLD 100 V A+ TG ++ K + ++ H N+ G+++V + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRP-------YIQLPSHSNITGIVEVILGE---- 70 Query: 101 DFTDFYLVMPFMGTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL 159 T Y+ D+ ++ ++L E+ L Q++ + + H + I+ DLK Sbjct: 71 --TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 128 Query: 160 AVN--EDCELKIL---DFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT-QTVDIWSVG 213 + E +L++ D + + D ++ Y +PE++ Y+ + D+WS+G Sbjct: 129 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 188 Query: 214 CIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDF 273 ++ ++ G+ F SD +I + P Sbjct: 189 VMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE-------------------------- 222 Query: 274 ASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 + SP A L+ +L + +R+TA E L HP+FES+ Sbjct: 223 -----HISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 258 >5CEK-A nrPDB Length = 263 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 108/281 (38%), Gaps = 51/281 (18%) Query: 41 VCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLD 100 V A+ TG ++ K + ++ H N+ G+++V + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRP-------YIQLPSHSNITGIVEVILGE---- 73 Query: 101 DFTDFYLVMPFMGTDLGKLMK-HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL 159 T Y+ D+ ++ ++L E+ L Q++ + + H + I+ DLK Sbjct: 74 --TKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKF 131 Query: 160 AVN--EDCELKIL---DFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT-QTVDIWSVG 213 + E +L++ D + + D ++ Y +PE++ Y+ + D+WS+G Sbjct: 132 VFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLG 191 Query: 214 CIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDF 273 ++ ++ G+ F SD +I + P Sbjct: 192 VMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE-------------------------- 225 Query: 274 ASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 + SP A L+ +L + +R+TA E L HP+FES+ Sbjct: 226 -----HISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 261 >2H34-A nrPDB Length = 309 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 65/254 (25%), Positives = 109/254 (42%), Gaps = 15/254 (5%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSE-LFAKRAYRELRLLKHMRHEN 85 YR + VG G G V A D VA+K + S+ +F R RE R ++ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHE-KLGEDRIQFLVYQMLKGLRY 143 V+ + D D Y+ M + DL +++ + L R +V Q+ L Sbjct: 96 VVPIHDFGEIDG------QLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 144 IHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----MTGYVVTRWYRAPEVILN 199 HAAG HRD+KP N+ V+ D ++DFG+A E + V T +Y APE + Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FS 208 Query: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 T DI+++ C++ E +TG ++G D L + + P+ + Sbjct: 209 ESHATYRADIYALTCVLYECLTGSPPYQG-DQLSVMGAHINQAIPRPSTVRPGIPVAFDA 267 Query: 260 NYMKGLPELEKKDF 273 +G+ + + + Sbjct: 268 VIARGMAKNPEDRY 281 >5E8V-A nrPDB Length = 316 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 113/300 (37%), Gaps = 46/300 (15%) Query: 33 VGSGAYGAVCSAVDGRTG----AKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENVI 87 VG G + V A + VA+K Y + S K + ++ ++HEN++ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LKHENIL 72 Query: 88 GLLDVFTPDETLDDFTDFYLVMPF-MGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 L + + ++L+ F +L + + + + ++ L + +G+ ++H+ Sbjct: 73 QFLTA--EERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS 130 Query: 147 ---------AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM-------TGYVVTRW 190 I+HRDLK N+ V D + DFGL+ + D + +G V T Sbjct: 131 DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTAR 190 Query: 191 YRAPEVILNWMRYT-----QTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTP 245 Y APEV+ + M + D++S+ ++ EM + + P Sbjct: 191 YMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYE-----------P 239 Query: 246 PAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS--PLAVNLLEKMLVLDAEQRVTAG 303 P R A L + + + S N + L + D E R+TA Sbjct: 240 PFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQ 299 >3LMG-A nrPDB Length = 344 Score = 153 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 50/271 (18%), Positives = 107/271 (39%), Gaps = 21/271 (7%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY---RELRLLKHMRHE 84 R L+ +GSG +G V V G + I + + + + + + + H Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHA 93 Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEK-LGEDRIQFLVYQMLKGL 141 +++ LL + + LV ++ G+ L + +H LG + Q+ KG+ Sbjct: 94 HIVRLLGLC-------PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGM 146 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW-----YRAPEV 196 Y+ G++HR+L N+ + ++++ DFG+A + + + + A E Sbjct: 147 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 197 ILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 I ++ +YT D+WS G + E++T G + G + + K + + Sbjct: 207 I-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQIC-TIDV 264 Query: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVN 286 + E + F + + +A + Sbjct: 265 YMVMVKCWMIDENIRPTFKELANEFTRMARD 295 >2Y4I-B nrPDB Length = 319 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 128/310 (41%), Gaps = 44/310 (14%) Query: 19 TAWEVR-AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 W++ + +G G +G V GR +VAI+ + +E K RE+ Sbjct: 26 QEWDIPFEQLEIGELIGKGRFGQVY---HGRWHGEVAIRLIDIERDNEDQLKAFKREVMA 82 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK--LGEDRIQFLVY 135 + RHENV+ + L T G L +++ K L ++ + + Sbjct: 83 YRQTRHENVVLFMGACMSPPHLAIITSLC-----KGRTLYSVVRDAKIVLDVNKTRQIAQ 137 Query: 136 QMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGL--------ARQADSEMTGYVV 187 +++KG+ Y+HA GI+H+DLK N+ + + ++ I DFGL A + + ++ Sbjct: 138 EIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNG 196 Query: 188 TRWYRAPEVI--------LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIM 239 + APE+I + + +++ D++++G I E+ + FK + ++ Sbjct: 197 WLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMG 256 Query: 240 KVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQR 299 Q E + + E+++ + +++LEK+ + +R Sbjct: 257 TGMK---PNLSQIGMGKEISDILLFCWAFEQEERPTFTK-----LMDMLEKLPKRN--RR 306 Query: 300 VTAGEALAHP 309 ++ HP Sbjct: 307 LS------HP 310 >4LQP-A nrPDB Length = 508 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 119/337 (35%), Gaps = 58/337 (17%) Query: 25 AVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQ-SELFAKRAYRELRLLKHMRH 83 + ++ +G GA+G V TG A+K L + + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LMKHEKLGEDRIQFLVYQMLKGL 141 V+ L F D YL+M F+ G DL L++ + ED +F + + + + Sbjct: 162 PWVVSLYYSF------QDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR---------------QADSEMTGYV 186 IH G IHR +KP N+ ++ +K+ DFGL+ Q D G Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGIS 275 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGC--------------IMAEMITGKT-------- 224 Y A R T VD S+ +MA G Sbjct: 276 KPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIF 335 Query: 225 LFKG---SDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 L++G L IM F + + M L+ D + S Sbjct: 336 LYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPD----DIHIS 391 Query: 282 PLAVNLLEKMLVLDAEQRV----TAGEALAHPYFESL 314 A +L+ ++L A+QR+ A E +HP+F + Sbjct: 392 YEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRGV 427 >5AR8-A nrPDB Length = 326 Score = 150 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 111/296 (37%), Gaps = 46/296 (15%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAIKKL-YRPFQSELFAKRAYRELRLLKHMRHENVI 87 DL+ + GA G V SA +VA+K L + K RE +L R ++ Sbjct: 36 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYIL 95 Query: 88 GLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDRIQ----FLVYQMLKGLR 142 +L + E L +V +M L +L+ + D +++++ G+ Sbjct: 96 PILGICNEPEFLG------IVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVN 149 Query: 143 YIHAAG--IIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV--------VTRWYR 192 Y+H ++H DLK N+ ++ + +KI DFGL++ ++ T Y Sbjct: 150 YLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYM 209 Query: 193 APEVIL--NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 PE R + DI+S I E+++ K F+ + Q+ Sbjct: 210 PPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQI--------------- 254 Query: 251 QRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 P + ++ + + ++L+E + ++R + + L Sbjct: 255 ------MYSVSQGHRPVINEESLPYDIPHR-ARMISLIESGWAQNPDERPSFLKCL 303 >2QLU-A nrPDB Length = 314 Score = 148 bits (374), Expect = 3e-36, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 117/301 (38%), Gaps = 36/301 (11%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 R + L+ G +G V A VA+K + ++ RE+ M+H Sbjct: 14 RGSLQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE---REIFSTPGMKH 68 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEKLGEDRIQFLVYQMLKGLR 142 EN++ + L+ + +L+ F L +K + + + + M +GL Sbjct: 69 ENLLQFIAAEKRGSNLE--VELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLS 126 Query: 143 YIHA-----------AGIIHRDLKPGNLAVNEDCELKILDFGLARQADS-----EMTGYV 186 Y+H I HRD K N+ + D + DFGLA + + + G V Sbjct: 127 YLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQV 186 Query: 187 VTRWYRAPEVILNWMRYTQ----TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVT 242 TR Y APEV+ + + + +D++++G ++ E+++ G L ++ Sbjct: 187 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIG 246 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTA 302 P E +Q + + L+ A + +E+ DAE R++A Sbjct: 247 QHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT--------IEECWDHDAEARLSA 298 Query: 303 G 303 G Sbjct: 299 G 299 >5L2Q-C nrPDB Length = 320 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 107/304 (35%), Gaps = 67/304 (22%) Query: 42 CSAVDGRTGAKVAIKKLYRPFQSELFAKR---------AYRELRLLKHMRHEN-VIGLLD 91 C A T +K L + + + + E LL + ++ V+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 92 VFTPDET------------LDDFTDFYLVMP-FMGTDL-----------GKLMKHEKLGE 127 +F LV+ D ++K ++L E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDFGLARQADSE---MT 183 + Y +++ + +H I+HRDLK GN+ +N+ + I +F L + SE + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 + Y +P+V+ + D+W++G ++ M+ G+ F S + ++I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 T P + S V L+ K+LVLD +QR+ A Sbjct: 273 TIPED-----------------------------GRVSENTVCLIRKLLVLDPQQRLAAA 303 Query: 304 EALA 307 + L Sbjct: 304 DVLE 307 >5VC6-A nrPDB Length = 289 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 109/307 (35%), Gaps = 64/307 (20%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-RHEN 85 + +L+ +GSG +G+V V G AIK+ +P + + A RE+ + +H + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-----KLGEDRIQFLVYQMLKG 140 V+ + D+ + ++ G L + E ++ L+ Q+ +G Sbjct: 73 VVRYFSAWAEDDHMLIQNEYC-----NGGSLADAISENYRIMSYFKEAELKDLLLQVGRG 127 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCEL-------------------KILDFGLARQADSE 181 LRYIH+ ++H D+KP N+ ++ KI D G + S Sbjct: 128 LRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSP 187 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 +R + A EV+ + DI+++ + G + DQ EI + Sbjct: 188 QVEEGDSR-FLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP--RNGDQWHEIRQG 243 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVT 301 I S LL+ M+ D E+R + Sbjct: 244 R------------------------------LPRIPQVLSQEFTELLKVMIHPDPERRPS 273 Query: 302 AGEALAH 308 A + H Sbjct: 274 AMALVKH 280 >3SV0-A nrPDB Length = 483 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 119/300 (39%), Gaps = 46/300 (15%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 V +R + +GSG++G + + +T +VAIK + + E ++ + ++ Sbjct: 5 VGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK----LENVKTKHPQLLYESKIYRILQ 60 Query: 83 H----ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQ 136 N + V + LVM +G L L KL + L Q Sbjct: 61 GGTGIPN-VRWFGV--------EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQ 111 Query: 137 MLKGLRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMTGYVVTRWYRA 193 M+ + ++H+ +HRD+KP N + ++ I+DFGLA++ T + YR Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIP--YRE 169 Query: 194 PEVILNWMRY-----------TQTVDIWSVGCIMAEMITGKTLFKGS---DHLDQLKEI- 238 + + RY ++ D+ S+G ++ + G ++G + ++I Sbjct: 170 NKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKIS 229 Query: 239 MKVTGTPPAEFVQRLQSDEAK--NYMKGLPELEKKDFASILTNASPLAVNL-LEKMLVLD 295 K T + ++ A +Y + L +K D++ + L +L + + D Sbjct: 230 EKKVATSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYL----KRLFRDLFIREGFQFD 285 >6BFN-A nrPDB Length = 342 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 80/214 (37%), Gaps = 31/214 (14%) Query: 32 PVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL--FAKRAYRELRLLKHMRHENVIGL 89 +G G +G V AV T A+K+L E + E+ L RH N++ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 90 LDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHE-----KLGEDRIQFLVYQMLKGLRY 143 + + LV F+ L + + L + ++ + +++ Sbjct: 87 AGYCAQNGF------YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQF 140 Query: 144 IH--AAGIIHRDLKPGNLAVNEDCELKILDFGLAR------------QADSEMTGYVVTR 189 +H + +IH D+K N+ ++E K+ DFGLAR + T Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGK 223 Y PE + R D +S G ++ E + G+ Sbjct: 201 AYL-PEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5J0A-A nrPDB Length = 300 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 107/304 (35%), Gaps = 47/304 (15%) Query: 31 QPVGSGAYGA---VCSAVDGRTG---AKVAIKKLY---RPFQSELFAKRAYRELRLLKHM 81 Q +G +G V G + A+KK+ ++ KR E ++LK + Sbjct: 15 QKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGT-DLGKLMKHE------KLGEDRIQFLV 134 H N++G T + L M + G L L++ I + Sbjct: 72 HHPNIVGYRAF-----TEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVA 126 Query: 135 YQMLKGLRYIHA-AGIIHRDLKPGNLAVNEDCE-LKILDFGLARQADSEMTG------YV 186 M +GL+Y+H ++H D+K N+ + D E +KI D G++ D M Y+ Sbjct: 127 LNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYI 186 Query: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 T ++ E + T DI++ G + EM+T H++ + T Sbjct: 187 GTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKTFD 241 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG--- 303 + Y L + L + + L D + R +A Sbjct: 242 ESDFD------DEAYYAALGTRPPINMEE-LDESYQKVIELFSVCTNEDPKDRPSAAHIV 294 Query: 304 EALA 307 EAL Sbjct: 295 EALE 298 >4TN6-A nrPDB Length = 318 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 117/290 (40%), Gaps = 37/290 (12%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 V YR + +GSG++G + D G +VAIK + + + E ++ K M+ Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK----LECVKTKHPQLHIESKIYKMMQ 60 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 G + + T + +VM +G L L K + L QM+ Sbjct: 61 -----GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 141 LRYIHAAGIIHRDLKPGNLAV---NEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVI 197 + YIH+ IHRD+KP N + + + I+DFGLA++ T + YR + + Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIP--YRENKNL 173 Query: 198 LNWMRY-----------TQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQLKEI-MKVT 242 RY ++ D+ S+G ++ G ++G + + + I K Sbjct: 174 TGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKM 233 Query: 243 GTPPAEFVQRLQSDEAK--NYMKGLPELEKKDFASILTNASPLAVNLLEK 290 TP + S+ A N+ + L +K D++ + L NL + Sbjct: 234 STPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLR----QLFRNLFHR 279 >2C47-A nrPDB Length = 313 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 128/327 (39%), Gaps = 41/327 (12%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 + +R + +G G +G + + T VAIK P +S A + + E R K + Sbjct: 2 MGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLS 57 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 + + F P + +V+ +G L L + + Q++ Sbjct: 58 ATEGVPQVYYFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITR 112 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQ-ADSEMTGYV-------- 186 + Y+H +I+RD+KP N V + I+DFGLA++ D E ++ Sbjct: 113 MEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSL 172 Query: 187 -VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG-- 243 T Y + L + ++ D+ ++G + + G ++G D LKE + G Sbjct: 173 TGTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDT 230 Query: 244 ---TPPAEFVQRLQSDEAK--NYMKGLPELEKKDFASILTNASPLAVNLLEKM-LVLDAE 297 TP + + A Y++ L EK D+ + L +L ++ V D E Sbjct: 231 KRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRK----LFTDLFDRSGFVFDYE 286 Query: 298 QRVTAGEALAHPYFESLHDTEDEPQVQ 324 AG+ L P D +PQ++ Sbjct: 287 YD-WAGKPLPTPIGTVHTDLPSQPQLR 312 >5FQD-C nrPDB Length = 341 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 56/285 (19%), Positives = 110/285 (38%), Gaps = 39/285 (13%) Query: 17 TKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELR 76 +K + V Y+ ++ +GSG++G + A++ G +VA+K + + E + Sbjct: 11 SKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK----LESQKARHPQLLYESK 66 Query: 77 LLKHMRH----ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRI 130 L K ++ ++ + LVM +G L L + + Sbjct: 67 LYKILQGGVGIPHI-RWYG--------QEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTV 117 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCEL---KILDFGLARQADSEMT---- 183 L QM+ + Y+H IHRD+KP N + ++DFGLA++ T Sbjct: 118 LMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHI 177 Query: 184 ------GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQ 234 T Y + L + ++ D+ S+G ++ ++G + + Sbjct: 178 PYREDKNLTGTARYASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQK 236 Query: 235 LKEIMKVTGTPPAEFVQRLQSDE---AKNYMKGLPELEKKDFASI 276 ++I + + P E + + E NY +GL E D+ + Sbjct: 237 YEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYL 281 >2CHL-A nrPDB Length = 351 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 62/323 (19%), Positives = 118/323 (36%), Gaps = 43/323 (13%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 S Y Q + V +R + +G G +G + + T VAIK Sbjct: 9 SGVDLGTENLYFQSMGVLM--VGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK----L 62 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK 121 + A + + E R K + + I + F P + +V+ +G L L Sbjct: 63 EPMKSRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNA-----MVLELLGPSLEDLFD 117 Query: 122 --HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGL 174 + + Q++ + Y+H+ +I+RD+KP N + + I+DF L Sbjct: 118 LCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFAL 177 Query: 175 ARQ-ADSEMTGYV---------VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT 224 A++ D E ++ T Y + L + ++ D+ ++G + + G Sbjct: 178 AKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSL 236 Query: 225 LFKGSDHLDQLKEIMKVTG-----TPPAEFVQRLQS-DEAKNYMKGLPELEKKDFASILT 278 ++G D LKE + G TP + Y++ L EK D+ + Sbjct: 237 PWQGLK-ADTLKERYQKIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRK 295 Query: 279 NASPLAVNLLEK---MLVLDAEQ 298 L +L ++ M + + Sbjct: 296 ----LFTDLFDRKGYMFDYEYDW 314 >4BTK-A nrPDB Length = 337 Score = 138 bits (347), Expect = 5e-33, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 117/296 (39%), Gaps = 36/296 (12%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS V K W+V L+ +G G +G + A+D T VA+K Sbjct: 38 MSGGGEQADILPANYVVKDRWKV------LKKIGGGGFGEIYEAMDLLTRENVALKV--- 88 Query: 61 PFQSELFAKRAYR-ELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGK 118 +S K+ + E+ +LK ++ ++V + +E + Y+VM G +L Sbjct: 89 --ESAQQPKQVLKMEVAVLKKLQGKDHVCRFIG-CGRNEKFN-----YVVMQLQGRNLAD 140 Query: 119 LMKHEK---LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL----AVNEDCELKILD 171 L + + L Q+L+ + IH+ G +HRD+KP N + + +LD Sbjct: 141 LRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLD 200 Query: 172 FGLARQADSEM---------TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 FGLARQ + G+ T Y + N + D+WS+ ++ E G Sbjct: 201 FGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVG 259 Query: 223 KTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILT 278 + ++ +Q+ I + + +++ L K D+ I++ Sbjct: 260 QLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 315 >4BTF-A nrPDB Length = 469 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 99/281 (35%), Gaps = 45/281 (16%) Query: 39 GAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--RELRLLKHMRHENVIGLLDVFTPD 96 + R+ V IK P + R E++ +K N++ + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 97 ETLDDFTDFYLVMPFMG-TDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDL 154 +F +VM + L +L+ EK L LV + +GL +H + +HR++ Sbjct: 267 TV--KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNI 324 Query: 155 KPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW-------YRAPEVILN-WMRYTQT 206 + V ++K+ F L++ +S T+ Y +PE + N + Y Sbjct: 325 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 384 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 +I+S G ++ E+ TGK F+G D + + + P Sbjct: 385 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEP-------------------- 424 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + + L ++ + + QR + L Sbjct: 425 ---------VGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >4NFN-A nrPDB Length = 309 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 117/296 (39%), Gaps = 36/296 (12%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 MS V K W+V L+ +G G +G + A+D T VA+K Sbjct: 3 MSGGGEQADILPANYVVKDRWKV------LKKIGGGGFGEIYEAMDLLTRENVALKV--- 53 Query: 61 PFQSELFAKRAYR-ELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGK 118 +S K+ + E+ +LK ++ ++V + +E + Y+VM G +L Sbjct: 54 --ESAQQPKQVLKMEVAVLKKLQGKDHVCRFIG-CGRNEKFN-----YVVMQLQGRNLAD 105 Query: 119 LMKHEK---LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL----AVNEDCELKILD 171 L + + L Q+L+ + IH+ G +HRD+KP N + + +LD Sbjct: 106 LRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLD 165 Query: 172 FGLARQADSEM---------TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITG 222 FGLARQ + G+ T Y + N + D+WS+ ++ E G Sbjct: 166 FGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEFAVG 224 Query: 223 KTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILT 278 + ++ +Q+ I + + +++ L K D+ I++ Sbjct: 225 QLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 280 >4M69-B nrPDB Length = 283 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 99/281 (35%), Gaps = 45/281 (16%) Query: 39 GAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAY--RELRLLKHMRHENVIGLLDVFTPD 96 + R+ V IK P + R E++ +K N++ + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 97 ETLDDFTDFYLVMPFMG-TDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYIHAAGIIHRDL 154 +F +VM + L +L+ EK L LV + +GL +H + +HR++ Sbjct: 81 TV--KPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNI 138 Query: 155 KPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRW-------YRAPEVILN-WMRYTQT 206 + V ++K+ F L++ +S T+ Y +PE + N + Y Sbjct: 139 SSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIK 198 Query: 207 VDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLP 266 +I+S G ++ E+ TGK F+G D + + + P Sbjct: 199 AEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEP-------------------- 238 Query: 267 ELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + + L ++ + + QR + L Sbjct: 239 ---------VGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >2CMW-A nrPDB Length = 310 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 115/289 (39%), Gaps = 42/289 (14%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH--EN 85 R + +G G +G + + T VAIK P +S A + + E R K + E Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK--LEPIKSR--APQLHLEYRFYKQLGSAGEG 58 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKGLRY 143 + + F P + +V+ +G L L + + Q+L + Y Sbjct: 59 LPQVY-YFGPCGKYNA-----MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEY 112 Query: 144 IHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQ-ADSEMTGYV---------VT 188 +H+ +I+RD+KP N + + I+DFGLA++ D E ++ T Sbjct: 113 VHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 172 Query: 189 RWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG----- 243 Y + L + ++ D+ ++G + + G ++G D LKE + G Sbjct: 173 ARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRN 230 Query: 244 TPPAEFVQRLQSDEAK--NYMKGLPELEKKDFASILTNASPLAVNLLEK 290 TP + + A Y++ L EK D+ + T L +L EK Sbjct: 231 TPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRT----LFTDLFEK 275 >5VDK-A nrPDB Length = 297 Score = 133 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 54/311 (17%), Positives = 107/311 (34%), Gaps = 68/311 (21%) Query: 24 RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM-R 82 + +++ +G G +G V + G AIK+ + F A E+ + Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH-----EKLGEDRIQFLVYQM 137 H +V+ + D+ + ++ G L + E +++ ++ Q+ Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYC-----NGGSLQAAISENTKSGNHFEEPKLKDILLQI 128 Query: 138 LKGLRYIHAAGIIHRDLKPGNL-----------------------AVNEDCELKILDFGL 174 GL YIH + ++H D+KP N+ ++ + KI D G Sbjct: 129 SLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGH 188 Query: 175 ARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQ 234 A + +R + A E++ R+ DI+++G +A + G Sbjct: 189 ATSINKPKVEEGDSR-FLANEILQEDYRHLPKADIFALGLTIA-VAAG------------ 234 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVL 294 ++ + K +F + S +LL+ M+ Sbjct: 235 --------------------AESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQP 274 Query: 295 DAEQRVTAGEA 305 DAEQR +A Sbjct: 275 DAEQRPSAAAL 285 >4JRN-A nrPDB Length = 372 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 64/345 (18%), Positives = 116/345 (33%), Gaps = 75/345 (21%) Query: 5 PPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKK-LYRPFQ 63 PP + V+ T E R + R P+GSG + V A D T ++A+K + Sbjct: 52 PPDVPKRF---VSVTTGETRTLVR-GAPLGSGGFATVYEATDVETNEELAVKVFMSEKEP 107 Query: 64 SELFAKRAYRELRLLKHMRH----------------ENVIGLLDVFTPDETLDDFT---- 103 ++ RE ++ +V+ L E + T Sbjct: 108 TDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWV 167 Query: 104 -DFYLVMPFMGTDLGKLM---------KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRD 153 +++L+M D+ K++ + G +L Q +K + + A GI+H D Sbjct: 168 PNYFLLMMRAEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTD 227 Query: 154 LKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMR--YTQTVDIWS 211 +KP N + +D L + DFG R ++ + + T Y PE YT D W Sbjct: 228 IKPANFLLLKDGRLFLGDFGTYR-INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQ 286 Query: 212 VGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKK 271 +G + + + D L Sbjct: 287 LGITLYCIWCKERPTPADGIWDYLH----------------------------------- 311 Query: 272 DFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 + + L +L+ +L D ++R+ +AL F+ + Sbjct: 312 --FADCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEMDS 354 >4MWI-A nrPDB Length = 294 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 103/269 (38%), Gaps = 45/269 (16%) Query: 53 VAIKKLYRPFQSEL--FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMP 110 VAIK + + + +E++ +K N++ + + + F +VM Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETV--TPPQFSIVME 107 Query: 111 FMG-TDLGKLMKHEK-LGEDRIQFLVYQMLKGLRYIHAAGI--IHRDLKPGNLAVNEDCE 166 + L +L+ EK L + LV +GL +H + +H ++ N V + + Sbjct: 108 YCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ 167 Query: 167 LKILDFGLARQADS-------EMTGYVVTRWYRAP-EVILNWMRYTQTVDIWSVGCIMAE 218 +K+ F L + S E T V + Y +P E+ + +Y +I+S G ++ E Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE 227 Query: 219 MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILT 278 + TG F+G + +++++++ V K+ + Sbjct: 228 IATGDIPFQGCN-SEKIRKLVAV----------------------------KRQQEPLGE 258 Query: 279 NASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + ++++ D R + E L Sbjct: 259 DCPSELREIIDECRAHDPSVRPSVDEILK 287 >3VHK-A nrPDB Length = 368 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 44/195 (22%), Positives = 77/195 (39%), Gaps = 36/195 (18%) Query: 120 MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD 179 + + L + + +Q+ KG+ ++ + IHRDL N+ ++E +KI DFGLAR Sbjct: 192 LYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 251 Query: 180 SE-----MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLD 233 + + + APE I + + YT D+WS G ++ E+ + G + + G Sbjct: 252 KDPDYVRKGDARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVK--- 307 Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 EF +RL K + D+ +P + Sbjct: 308 -----------IDEEFCRRL---------KEGTRMRAPDYT------TPEMYQTMLDCWH 341 Query: 294 LDAEQRVTAGEALAH 308 + QR T E + H Sbjct: 342 GEPSQRPTFSELVEH 356 Score = 71.1 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 14/120 (11%) Query: 13 RQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSA----VDG-RTGAKVAIKKLYRPFQSEL 66 R + WE R + +P+G GA+G V A +D T VA+K L + + Sbjct: 16 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKML-KEGATHS 74 Query: 67 FAKRAYRELRLLKHMRHE-NVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK 124 + EL++L H+ H NV+ LL T +++ F +L ++ ++ Sbjct: 75 EHRALMSELKILIHIGHHLNVVNLLGACTKPG-----GPLMVIVEFCKFGNLSTYLRSKR 129 >4NT4-A nrPDB Length = 312 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 108/297 (36%), Gaps = 45/297 (15%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM- 81 V +R + +G G +G + + VAIK + A + + E R K + Sbjct: 10 VGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKAPQLHLEYRFYKLLG 65 Query: 82 RH-----ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLV 134 H + + + + T + +V+ +G L L K + + Sbjct: 66 SHADNAPDGIPRIYHLGTCGGRYNA-----MVLELLGLSLEDLFNICARKFSLKTVLMIA 120 Query: 135 YQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQA----------D 179 Q+L + Y+H+ +I+RD+KP N + + I+DFGLA++ Sbjct: 121 KQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPY 180 Query: 180 SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQLK 236 E T Y + + + ++ D+ ++G + + G ++G ++ + Sbjct: 181 REHKSLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQ 239 Query: 237 EIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 +I P E + +E Y++ + L+ + + L ++ Sbjct: 240 KIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY---------DFLRRLFQ 287 >2PZI-A nrPDB Length = 681 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 113/301 (37%), Gaps = 44/301 (14%) Query: 5 PPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR-TGAKVAIKKLYRPFQ 63 P S + V Y + G G + A+D G V +K L Sbjct: 60 PYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGD 119 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE 123 +E A + L + H +++ + + + D Y+VM ++G K K + Sbjct: 120 AEAQAMAMAE-RQFLAEVVHPSIVQIFNFVEHTDRHGDPVG-YIVMEYVGGQSLKRSKGQ 177 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 KL + ++L L Y+H+ G+++ DLKP N+ + E+ +LK++D G + +S Sbjct: 178 KLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY 236 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 Y T ++APE++ T DI++VG +A + T Sbjct: 237 LY-GTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL-TLDLP------------------ 274 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 Y+ GLPE + +L LL + + D QR T Sbjct: 275 ------------TRNGRYVDGLPEDDP-----VLKTYDSYGR-LLRRAIDPDPRQRFTTA 316 Query: 304 E 304 E Sbjct: 317 E 317 >4Y12-A nrPDB Length = 375 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 113/301 (37%), Gaps = 44/301 (14%) Query: 5 PPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR-TGAKVAIKKLYRPFQ 63 P S + V Y + G G + A+D G V +K L Sbjct: 99 PYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGD 158 Query: 64 SELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE 123 +E A + L + H +++ + + + D Y+VM ++G K K + Sbjct: 159 AEAQAMAMAE-RQFLAEVVHPSIVQIFNFVEHTDRHGDPVG-YIVMEYVGGQSLKRSKGQ 216 Query: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 KL + ++L L Y+H+ G+++ DLKP N+ + E+ +LK++D G + +S Sbjct: 217 KLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGY 275 Query: 184 GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTG 243 Y T ++APE++ T DI++VG +A + T Sbjct: 276 LY-GTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL-TLDLP------------------ 313 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 Y+ GLPE + +L LL + + D QR T Sbjct: 314 ------------TRNGRYVDGLPEDDP-----VLKTYDSYGR-LLRRAIDPDPRQRFTTA 355 Query: 304 E 304 E Sbjct: 356 E 356 >3HNG-A nrPDB Length = 360 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 39/190 (20%), Positives = 75/190 (39%), Gaps = 36/190 (18%) Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA--D 179 E + + + +Q+ +G+ ++ + IHRDL N+ ++E+ +KI DFGLAR + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 180 SEMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQL 235 + TR + APE I + + Y+ D+WS G ++ E+ + G + + G Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPG------- 304 Query: 236 KEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLD 295 + + S + PE + I+ + D Sbjct: 305 -----------VQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLD-----------CWHRD 342 Query: 296 AEQRVTAGEA 305 ++R E Sbjct: 343 PKERPRFAEL 352 Score = 74.6 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 50/132 (37%), Gaps = 14/132 (10%) Query: 1 MSSPPPARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSA-----VDGRTGAKVA 54 M P R + WE R + + +G GA+G V A T VA Sbjct: 2 MPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVA 61 Query: 55 IKKLYRPFQSELFAKRAYRELRLLKHMRHE-NVIGLLDVFTPDETLDDFTDFYLVMPFMG 113 +K L + + K EL++L H+ H NV+ LL T +++ + Sbjct: 62 VKMLKEGATASEY-KALMTELKILTHIGHHLNVVNLLGACTKQG-----GPLMVIVEYCK 115 Query: 114 -TDLGKLMKHEK 124 +L +K ++ Sbjct: 116 YGNLSNYLKSKR 127 >5X1R-A nrPDB Length = 302 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 111/290 (38%), Gaps = 49/290 (16%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKK------------LYRPFQSELFAKRA--- 71 + + +G G +G V A D + +AIK+ L + E F K Sbjct: 23 FEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAG 82 Query: 72 ----YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE--KL 125 +E RLL H ++ +L + + T T FY GT L L + K+ Sbjct: 83 LNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYS-----GTTLKNLQAQQPEKI 137 Query: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQAD---SEM 182 E I+ L+ + + IH G +HRD+ N+ + E +LDFG AR+ S+ Sbjct: 138 DEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDE 197 Query: 183 TGYVVTRWYRAPEVILNWMRYTQTV--------DIWSVGCIMAEMITGKTLFKGSDHLDQ 234 T V+ + E +YT+ DI+++G ++ +I G + Sbjct: 198 TEIVLKPGFAPIE------QYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSV 246 Query: 235 LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLA 284 ++ I + + P E S E + L+ +D + + L Sbjct: 247 VRSI-EDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELL 295 >4XHH-A nrPDB Length = 403 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 58/284 (20%), Positives = 109/284 (38%), Gaps = 31/284 (10%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 V +R + +GSG++G + + +G +VAI R + E R+ K++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYKYLS 60 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 I + F + + +V+ +G L L H K + L QM+ Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICR 115 Query: 141 LRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMTGYVVTRWYRAPEVI 197 ++YIH IHRD+KP N + + ++DFGL+++ T + YR + + Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP--YRENKSL 173 Query: 198 LNWMRY-----------TQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQLKEIMKVTG 243 RY ++ D+ S+G ++ G ++G + + I++ Sbjct: 174 TGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKL 233 Query: 244 TPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNL 287 E + E YM L+ + L + L +L Sbjct: 234 CISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLY-LARLFKDL 276 >5X18-A nrPDB Length = 295 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 48/274 (17%), Positives = 105/274 (38%), Gaps = 32/274 (11%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 V Y+ + +G G++G + + G VAIK + A + E + K + Sbjct: 5 VGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF----EPRKTEAPQLRDEYKTYKILN 60 Query: 83 -HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLK 139 N+ + E L + LV+ +G L L K + + QM+ Sbjct: 61 GTPNIP--YAYYFGQEGLHNI----LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMIT 114 Query: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQADSEMTGYV-------- 186 + +HA +I+RD+KP N + + + ++DFG+A+Q T Sbjct: 115 LIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKS 174 Query: 187 --VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQLKEIMKV 241 T Y + L + ++ D+ ++G + + G ++G ++ + ++I + Sbjct: 175 LSGTARYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEK 233 Query: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFAS 275 + + + + Y++ + L ++ Sbjct: 234 KRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPD 267 >4L68-A nrPDB Length = 340 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 110/271 (40%), Gaps = 35/271 (12%) Query: 39 GAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDET 98 G A+ G+ +A+K L E + E+ L +RH N+ LL +E Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGE---REFRYEMNQLWELRHSNLAPLLGFCVVEE- 108 Query: 99 LDDFTDFYLVMPFM-GTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYIHAAG---IIHR 152 + +LV +M L L+ + L + +GL ++H I+H+ Sbjct: 109 -----EKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQ 163 Query: 153 DLKPGNLAVNEDCELKILDFGLARQA-------DSEMTGYVVTRWYRAPEVILNWMRYTQ 205 ++ + ++ED + +I+D GLAR S MTG + Y APE M + Sbjct: 164 NICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLASL 222 Query: 206 TVDIWSVGCIMAEMITGKTL-----FKGS--DHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 D++ +G ++ E+ TG FKGS D + QL+ ++ T + +E Sbjct: 223 KGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEI 282 Query: 259 KNYMK----GLPELEKKDFASILTNASPLAV 285 +++ + K+ ++ S A+ Sbjct: 283 SKFVEIALNCVSSRPKERWSMFQAYQSLKAI 313 >4XHL-A nrPDB Length = 394 Score = 123 bits (310), Expect = 8e-29, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 112/287 (39%), Gaps = 33/287 (11%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 V +R + +GSG++G + + +G +VAI R + E R+ +++ Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI----RLESIRSRHPQLDYESRVYRYLS 60 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 I + F + + +V+ +G L L H + + L QM Sbjct: 61 GGVGIPFIRWFGREGEYNA-----MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCR 115 Query: 141 LRYIHAAGIIHRDLKPGNLAVN---EDCELKILDFGLARQADSEMTGYVVTRWYRAPEVI 197 ++YIH IHRD+KP N + + ++DFGL+++ T + YR + + Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP--YRENKSL 173 Query: 198 LNWMRY-----------TQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQLKEIMKVTG 243 RY ++ D+ S+G ++ G ++G + + IM+ Sbjct: 174 TGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 Query: 244 TPPAEFVQRLQSDEAKNYM---KGLPELEKKDFASILTNASPLAVNL 287 E + E + YM K L EK D+ + L++ L Sbjct: 234 NVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKL 280 >4RT7-A nrPDB Length = 415 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 44/224 (19%), Positives = 84/224 (37%), Gaps = 25/224 (11%) Query: 73 RELRLLKHMRHEN---VIGLLD-VFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGED 128 RE+++ H + + GL F ++ ++ L DL L + Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEIEYENQKRLEEE---EDLN------VLTFE 243 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV-- 186 + YQ+ KG+ ++ +HRDL N+ V +KI DFGLAR S+ V Sbjct: 244 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 303 Query: 187 ---VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVT 242 + + APE + + YT D+WS G ++ E+ + G + G ++++ Sbjct: 304 NARLPVKWMAPESLFEGI-YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNG 362 Query: 243 GTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVN 286 F + ++ F ++ + + Sbjct: 363 FKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLAD 406 Score = 81.5 bits (200), Expect = 6e-16, Method: Composition-based stats. Identities = 30/121 (24%), Positives = 53/121 (43%), Gaps = 15/121 (12%) Query: 12 YRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVD---GRTG--AKVAIKKLYRPFQSE 65 +R+ WE R + +GSGA+G V +A +TG +VA+K L S Sbjct: 51 FREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 110 Query: 66 LFAKRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHE 123 + EL+++ + HEN++ LL T + YL+ + DL ++ + Sbjct: 111 -EREALMSELKMMTQLGSHENIVNLLGACTLSGPI------YLIFEYCCYGDLLNYLRSK 163 Query: 124 K 124 + Sbjct: 164 R 164 >1CSN-A nrPDB Length = 298 Score = 114 bits (285), Expect = 8e-26, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 103/260 (39%), Gaps = 30/260 (11%) Query: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMR 82 V Y+ + +G G++G + + +VAIK + P +S+ A + E R K + Sbjct: 8 VGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK--FEPRRSD--APQLRDEYRTYKLL- 62 Query: 83 HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK--HEKLGEDRIQFLVYQMLKG 140 G+ +V+ + + LV+ +G L L+ K + QML Sbjct: 63 -AGCTGIPNVYYFGQ---EGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLAR 118 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCE-----LKILDFGLARQADSEMTGYV--------- 186 ++ IH +++RD+KP N + + ++DFG+ + +T Sbjct: 119 VQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNL 178 Query: 187 -VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG---SDHLDQLKEIMKVT 242 T Y + L + ++ D+ ++G + + G ++G + + + + I + Sbjct: 179 SGTARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKK 237 Query: 243 GTPPAEFVQRLQSDEAKNYM 262 + P + +E YM Sbjct: 238 QSTPLRELCAGFPEEFYKYM 257 >4L00-A nrPDB Length = 304 Score = 110 bits (276), Expect = 8e-25, Method: Composition-based stats. Identities = 48/332 (14%), Positives = 101/332 (30%), Gaps = 67/332 (20%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAV------DGRTGAKVAI 55 S+ Y ++ + +G G + S D T + I Sbjct: 2 STSAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKI 61 Query: 56 KKLYR--PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG 113 K + + + + +++ + H++++ L V D + +V F+ Sbjct: 62 KVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD------VENIMVEEFVE 115 Query: 114 T---DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE---- 166 DL K + L + Q+ L Y+ ++H ++ NL + + Sbjct: 116 GGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSEC 175 Query: 167 ---LKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEM-ITG 222 +K+ D G+ S W APE + + + D WS G + E+ G Sbjct: 176 GPFIKLSDPGIPITVLSRQECIERIPW-IAPECVEDSKNLSVAADKWSFGTTLWEICYNG 234 Query: 223 KTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP 282 + K ++ + + + Sbjct: 235 EIPLKDKTLIE-------------------------------KERFYESRCRPVTPSCKE 263 Query: 283 LAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 LA +L+ + + D QR P+F ++ Sbjct: 264 LA-DLMTRCMNYDPNQR---------PFFRAI 285 >5USZ-A nrPDB Length = 289 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 43/284 (15%), Positives = 104/284 (36%), Gaps = 40/284 (14%) Query: 31 QPVGSGAYGAVCSAVDGRTG-------AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRH 83 + +G G + + V G +V +K L + ++ +++ + ++ + H Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASMMSKLSH 71 Query: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKHEK--LGEDRIQFLVYQMLKG 140 ++++ V + + LV F+ L +K K + + Q+ Sbjct: 72 KHLVLNYGVCVCGD------ENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAA 125 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCE--------LKILDFGLARQADSE--MTGYVVTRW 190 + ++ +IH ++ N+ + + + +K+ D G++ + + + Sbjct: 126 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIP--- 182 Query: 191 YRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFV 250 + PE I N D WS G + E+ +G G L L K+ + Sbjct: 183 WVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSALDSQRKLQFYEDRHQL 237 Query: 251 QRLQSDEAKNYMKGLPELEK---KDFASILTNASPLAV-NLLEK 290 ++ E N + + E F +I+ + + L +L+ + Sbjct: 238 PAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVPR 281 >5M07-A nrPDB Length = 276 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 27/208 (12%) Query: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY-RPFQSELFAKRAYRELRLLKHMRHEN 85 Y ++ +G+ A G V A+K L + F +R RE + + H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 86 VIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEK---LGEDRIQFLVYQMLKGL 141 ++ + D + ++ M ++ G D + M L + +V + L Sbjct: 92 ILEVHD------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 142 RYIHAAGIIHRDLKPGNLAVNE----DCELKILDFGLARQADSEMTGYVVTRWYRAPEVI 197 Y H G++HRD+ P N+ + D + + DFG+A Q Y APE+ Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------PSYPAPELS 194 Query: 198 LNWMRYTQTVDIWSVGCIMAEMITGKTL 225 + D +++ + G Sbjct: 195 AGADVDGRA-DQYALALTAIHLFAGAPP 221 >5OAT-A nrPDB Length = 411 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 65/334 (19%), Positives = 102/334 (30%), Gaps = 92/334 (27%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGAK-----VAIKKLYRPFQSE---LFAKRAYRE---LRL 77 +P+ G G V SA A+K ++ E K YRE R+ Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 78 L-----------------KHMR-HENVIGLLDVFTP-----------DETLDDFTDFYLV 108 KH+ H N++ + VFT E +L+ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 109 MPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN----ED 164 M +L + L+ Q+L+G+ ++ A GI HRDLK NL ++ E Sbjct: 135 MKRYDCNLQSFLSTAP-STRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPES 193 Query: 165 CELKILDFG---------LARQADSEMTGYVVTRWYRAPEVILNWMR------YTQTVDI 209 L I DFG L+ S APE+I Y+ D+ Sbjct: 194 PILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-KADL 252 Query: 210 WSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE 269 W+VG I E+ F G L + Sbjct: 253 WAVGAIAYEIFNCHNPFYGPSRLKNFN-------------------------------YK 281 Query: 270 KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 + D + + L+ +L + +R+ Sbjct: 282 EGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >6EQI-C nrPDB Length = 433 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 59/345 (17%), Positives = 103/345 (29%), Gaps = 100/345 (28%) Query: 28 RDLQPVGSGAYGAVCSAVDG-----RTGAKVAIKKLYR---PFQSELFAKRAYRE----- 74 +P+ G V SA + ++A+K ++ S K YRE Sbjct: 18 DLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAM 77 Query: 75 ----------LRLLKHMR-----HENVIGLLDVFTP---------------------DET 98 + + + H N++ + VF E Sbjct: 78 SYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEG 137 Query: 99 LDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGN 158 +LVM L + ++ + L+ Q+L+ + +++ I HRDLK N Sbjct: 138 SGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVAHMNIHNISHRDLKSDN 197 Query: 159 LAVNED-----CELKILDF---------GLARQADSEMTGYVVTRWYRAPEVI------L 198 + V+ + I DF GL SE R APE+ Sbjct: 198 ILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKPGTF 257 Query: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 +W+ Y + D+W+VG I E+ F Sbjct: 258 SWLNY-KKSDLWAVGAIAYEIFNIDNPFYD------------------------------ 286 Query: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAG 303 K +++D + + NL+ ML +R+ Sbjct: 287 KTMKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >5UV4-A nrPDB Length = 311 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 77/208 (37%), Gaps = 21/208 (10%) Query: 31 QPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 + +G +G A G + +K L F K RE++ L +RH N++ L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK--KEFSREIKKLGSVRHPNLVPLR 87 Query: 91 DVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKH------EKLGEDRIQFLVYQMLKGLRY 143 + + + ++ + T L + L + + + + L Y Sbjct: 88 GYYWGPKEHERI----MISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDY 143 Query: 144 IHAAGII-HRDLKPGNLAV-NEDCELKILDFGLARQADS-EMTGYV---VTRWYRAPEVI 197 +H +I H ++K N+ + N + D+ L R M V Y PE Sbjct: 144 LHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFS 203 Query: 198 LNWMRY-TQTVDIWSVGCIMAEMITGKT 224 + D+++ G I+ E++TGK Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLTGKI 231 >3REP-A nrPDB Length = 271 Score = 101 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 45/273 (16%), Positives = 91/273 (33%), Gaps = 51/273 (18%) Query: 39 GAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFT--PD 96 G + G + +K L S ++ E L+ H NV+ +L P Sbjct: 24 GELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPA 81 Query: 97 ETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQMLKGLRYIHAAG-IIHR 152 T + MP+ L ++ + + + M +G+ ++H +I R Sbjct: 82 PHPTLITHW---MPY--GSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPR 136 Query: 153 -DLKPGNLAVNEDCELKI--LDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYT--QTV 207 L ++ ++ED +I D + Q+ M + APE + T ++ Sbjct: 137 HALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA----PAWVAPEALQKKPEDTNRRSA 192 Query: 208 DIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPE 267 D+WS ++ E++T + F +++ ++ P Sbjct: 193 DMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPT--------------------- 231 Query: 268 LEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300 I SP L++ + D +R Sbjct: 232 --------IPPGISPHVSKLMKICMNEDPAKRP 256 >5CLR-A nrPDB Length = 451 Score = 99.6 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 38/194 (19%), Positives = 77/194 (39%), Gaps = 23/194 (11%) Query: 42 CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDD 101 G +K + +S E L + L+ F ++T Sbjct: 96 FKVYALDDGKTYFLKSVKIDAES---LTEFTNEKDTLSKLG-----RLVGTFFNEQT--- 144 Query: 102 FTDFYLVMPFM-GTDLGKLMKHEKLGED-----RIQFLVYQMLKGLRYIHAAGIIHRDLK 155 Y++ F+ G DL + L + + ++ + ++ H G+IHRDLK Sbjct: 145 -QVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLK 203 Query: 156 PGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEV--ILNWMRYTQTVDIWSVG 213 PGN+ ++ D + ++DFG + T Y APE+ +++ ++Q D++++ Sbjct: 204 PGNIMLDADMQCHLVDFGSSSSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALA 263 Query: 214 CIMAEMITGKTLFK 227 + E+ F+ Sbjct: 264 YSLDELFN---PFR 274 >4IX6-A nrPDB Length = 350 Score = 96.2 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 62/342 (18%), Positives = 110/342 (32%), Gaps = 70/342 (20%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR-ELRLLKH 80 E + + P+GSG +G V V V L + A+ E+ + H Sbjct: 17 EPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYH 72 Query: 81 MRHEN----VIGLLDVFTPDETLDDFTDFYLVMP---FMGTDLGK-----LMKHEKLGED 128 + H N + + M + G+ LM+ Sbjct: 73 V-HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLA 131 Query: 129 RIQFL------------VYQMLKGLRYIHAAGIIHRDLKPGNLAVNED--CELKILDFG- 173 + ++L L +H G++HRD+KP NL E LK++D G Sbjct: 132 TAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGA 191 Query: 174 --LARQADSEMTGYVV-----TRWYRAPEVILNWMRYTQTV----------------DIW 210 L + Y R+ +A E+ L + D W Sbjct: 192 AALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSW 251 Query: 211 SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 S GC+M ++ + L++ K G F + E Sbjct: 252 SAGCVMLQLAV--VGLRTDAGLERFLADYKAVGYDVNAFR-----------GEKSGEYGT 298 Query: 271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 DFA++ N +L ++++ + + R + AL+H +F+ Sbjct: 299 MDFAALDANGGA-GWDLCQRLMEAERDARASCEAALSHAFFD 339 >5C01-A nrPDB Length = 342 Score = 95.0 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 40/277 (14%), Positives = 84/277 (30%), Gaps = 55/277 (19%) Query: 44 AVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFT 103 D +V +K L A Y L+ + H ++ + V Sbjct: 101 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP------ 152 Query: 104 DFYLVMPFM-GTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA 160 + +V ++ L ++ E+ + + Q+ L Y+ ++H ++ N+ Sbjct: 153 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 212 Query: 161 VNEDCE-------LKILD--FGLARQADSEMTGYVVTRWYRAPEVILNWMRY-TQTVDIW 210 + +K+ D GL + E + + APE + + +D W Sbjct: 213 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 269 Query: 211 SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 G + E+ F G +Q E +++ + L + Sbjct: 270 GFGATLLEIC-----FDGEAP------------------LQSRSPSEKEHFYQRQHRLPE 306 Query: 271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + T L + L + QR + L Sbjct: 307 PSCPQLAT--------LTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 94.3 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 40/277 (14%), Positives = 84/277 (30%), Gaps = 55/277 (19%) Query: 44 AVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFT 103 D +V +K L A Y L+ + H ++ + V Sbjct: 78 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP------ 129 Query: 104 DFYLVMPFM-GTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLA 160 + +V ++ L ++ E+ + + Q+ L Y+ ++H ++ N+ Sbjct: 130 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 161 VNEDCE-------LKILD--FGLARQADSEMTGYVVTRWYRAPEVILNWMRY-TQTVDIW 210 + +K+ D GL + E + + APE + + +D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLSTAMDKW 246 Query: 211 SVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK 270 G + E+ F G +Q E +++ + L + Sbjct: 247 GFGATLLEIC-----FDGEAP------------------LQSRSPSEKEHFYQRQHRLPE 283 Query: 271 KDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + T L + L + QR + L Sbjct: 284 PSCPQLAT--------LTSQCLTYEPTQRPSFRTILR 312 >4I94-A nrPDB Length = 300 Score = 93.5 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 40/266 (15%), Positives = 92/266 (34%), Gaps = 41/266 (15%) Query: 40 AVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETL 99 V ++A+K+ R + +++ E + + +R+ + LL DE Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPD--SRQFLEEAKAVGQLRNHRMANLLGCCYEDE-- 98 Query: 100 DDFTDFYLVMPFM-GTDLGKLM---KHEKLGEDRIQFLVYQMLKGLRYIHAAG-IIHRDL 154 + L+ FM L K + + + + + + + L Y + G ++ DL Sbjct: 99 ----ERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDL 154 Query: 155 KPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGC 214 + ++D ++ FGL + + Y + PE + T I+S G Sbjct: 155 NAYRVLFDDDANPRLSCFGLMKNSRDG-KSYSTNLAFTPPEYLRTGRV-TPESVIYSFGT 212 Query: 215 IMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFA 274 ++ ++++GK PP+ + ++ + M E Sbjct: 213 LLLDLLSGKH-------------------IPPSHALDLIRDRNIQMLMDSGLE------G 247 Query: 275 SILTNASPLAVNLLEKMLVLDAEQRV 300 ++ + L + L + +R Sbjct: 248 QFSSDDGTELIRLASRCLQYEPRERP 273 >6J6I-B nrPDB Length = 351 Score = 91.2 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 40/190 (21%), Positives = 71/190 (37%), Gaps = 25/190 (13%) Query: 53 VAIKKLYRPFQSELFA--KRAYRELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFYLVM 109 IK+ + K Y ++ L M H N + LL +F LV Sbjct: 84 YMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCL------EFPFPVLVF 137 Query: 110 PF-----MGTDLGKLMKHEK--LGEDRIQFLVYQMLKGLRYIHA---AGIIHRDLKPGNL 159 F M G ++ E+ L + ++ + Y+H IIHRD+KP ++ Sbjct: 138 EFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHV 197 Query: 160 AVNEDCELKILDFGLARQADSEMTG-----YVVTRWYRAPEVILNWMRYTQTVDIWSVGC 214 ++++ K+ D + + + T Y P + T+ D++S G Sbjct: 198 FLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGI 256 Query: 215 IMAEMITGKT 224 + +ITGK Sbjct: 257 CLLVIITGKP 266 >4CI6-B nrPDB Length = 643 Score = 87.3 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 114/286 (39%), Gaps = 42/286 (14%) Query: 57 KLYRPFQSELFAKRAYRELRLLKHM-----RHENVIGLLDVFTPDETLDDFTDFYLVMPF 111 +L + + + EL KH+ +H N+ + + + L+M Sbjct: 70 RLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHG--MAVVPYGNRYYYALLMDE 127 Query: 112 MGT--------DLGKLMKHEKLGED----RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL 159 + L K K+ + I+F+ +++L ++ AGI+H D+KPGN+ Sbjct: 128 VDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNV 187 Query: 160 AVNE-DCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAE 218 + E ++D GL ++ + G+ T ++APE+ + + ++ D++ +++ Sbjct: 188 VFDRASGEPVVIDLGLHSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF---LVVST 242 Query: 219 MITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILT 278 ++ G F+ + P + ++ + S+ A + + + A + T Sbjct: 243 LLHGIEGFEKDPEIK------------PNQGLRFITSEPAHVMDENGYPIHRPGIAGVET 290 Query: 279 NASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH-DTEDEPQV 323 + + +L + A+ R + EA H + D E Q+ Sbjct: 291 AYTR----FITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQI 332 >5UU1-A nrPDB Length = 324 Score = 86.9 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 84/229 (36%), Gaps = 38/229 (16%) Query: 29 DLQPVGSGAYGAVCSAV-----DGRTGAKVAI------------KKLYRPFQSELFAKRA 71 + +GSG +G + A + V + K R + + K Sbjct: 20 LGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWI 79 Query: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM-KHEKLGEDRI 130 R K + + + + + ++VM +G DL K+ ++ + + Sbjct: 80 ER-----KQLDYLGIPLFYGSGLTE--FKGRSYRFMVMERLGIDLQKISGQNGTFKKSTV 132 Query: 131 QFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV--NEDCELKILDFGLA----------RQA 178 L +ML L YIH +H D+K NL + ++ + D+GL+ + Sbjct: 133 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 192 Query: 179 DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFK 227 ++ G+ T + + + + ++ D+ +G M + GK ++ Sbjct: 193 ENPRKGHNGTIEFTSLDAHKG-VALSRRSDVEILGYCMLRWLCGKLPWE 240 >2RSV-A nrPDB Length = 403 Score = 77.3 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 94/245 (38%), Gaps = 41/245 (16%) Query: 15 EVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKV------AIKKL---------- 58 ++ K W+V P+G G +G + A D + V +K Sbjct: 38 DMAKKEWKVGL------PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTE 90 Query: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGK 118 + +Q ++ + +R + +++ V D+ + +++M G+DL K Sbjct: 91 LKFYQRAAKPEQIQKWIRT-RKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSDLQK 147 Query: 119 LM--KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGL 174 + ++ + L ++L L YIH +H D+K NL +N ++ ++D+GL Sbjct: 148 IYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGL 207 Query: 175 A----------RQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT 224 A + + T + + + ++ D+ +G M + +TG Sbjct: 208 AYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHL 266 Query: 225 LFKGS 229 ++ + Sbjct: 267 PWEDN 271 >2LAV-A nrPDB Length = 361 Score = 76.5 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 39/228 (17%), Positives = 88/228 (38%), Gaps = 35/228 (15%) Query: 32 PVGSGAYGAVCSAVDGRTGAKV------AIKKL----------YRPFQSELFAKRAYREL 75 P+G G +G + A D + V +K + +Q ++ + + Sbjct: 42 PIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWI 100 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM--KHEKLGEDRIQFL 133 R + +++ V D+ + +++M G+DL K+ ++ + L Sbjct: 101 RT-RKLKYLGVPKYWGSGLHDKNGKSYR--FMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC--ELKILDFGLA----------RQADSE 181 ++L L YIH +H D+K NL +N ++ ++D+GLA + Sbjct: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 Query: 182 MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGS 229 + T + + + ++ D+ +G M + +TG ++ + Sbjct: 218 KRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN 264 >4O1O-A nrPDB Length = 717 Score = 68.1 bits (165), Expect = 6e-12, Method: Composition-based stats. Identities = 40/276 (14%), Positives = 96/276 (34%), Gaps = 82/276 (29%) Query: 51 AKVAIKKLYRPFQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVM 109 +VA+K+ R +E+ L+ R ++NV+ + D + ++ + Sbjct: 370 QEVAVKRFSEGST------RGQQEVSCLQSSRANDNVVTFYG------SESDGSCLHVCL 417 Query: 110 PFMGTDLGKLMKHEKLG------EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE 163 L + + + + ++ + ++ + K + +H +G H+DL+P N+ ++ Sbjct: 418 ALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDS 477 Query: 164 DCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVG-CIMAEMITG 222 + DF + +W P+ I D+ ++G ++ + G Sbjct: 478 KNGTFLADFDKS------------IKWAEDPQKIKR--------DLEALGLLVLYVVKKG 517 Query: 223 KTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASP 282 F + L++ + ++G P Sbjct: 518 DISF------------------------ETLKNQSFEEVIQGSP--------------DE 539 Query: 283 LAVNLLEKMLVL--DAEQRVTAGEALAHPYFESLHD 316 +L+ + + E R+++ LAHP+F S Sbjct: 540 ETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWES 573 >6G4J-A nrPDB Length = 315 Score = 67.3 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 53/240 (22%), Positives = 87/240 (36%), Gaps = 42/240 (17%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRL 77 K W Y + +G GA G V A + VA+K E+ + Sbjct: 20 KGKWN-GNTYTLRKQLGKGANGIVYLAE--TSDGHVALKVSDDSLS-------ITSEVNV 69 Query: 78 LKHMRHENVIGLLDVFTPDETLDDFTDFYL----------VMPFM-GTDLGKLMKHEKLG 126 LK T + D D Y+ M ++ G L K + + G Sbjct: 70 LKSFSKA------QSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDK--G 121 Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLARQADSEMTGY 185 + I L+ Q+L L +H G I DLKP NL V ++ +D G + + Y Sbjct: 122 AEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY 181 Query: 186 VVTRWYRAPEVILNWMRYTQ-----TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240 T +Y + Y + D+++V IM + K K + +QL+ +++ Sbjct: 182 --TEFYD-----RGYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE 234 >2JII-A nrPDB Length = 352 Score = 66.9 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 34/205 (16%), Positives = 73/205 (35%), Gaps = 23/205 (11%) Query: 106 YLVMPFMGTDLG---KLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN 162 +LV+P +G L + L E + + ++L L ++H +H ++ N+ V+ Sbjct: 134 FLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 163 --EDCELKILDFGLARQADSEMTGYVVTRWYRAP-----EVIL----NWMRYTQTVDIWS 211 + ++ + +G A + R+P E I ++ D+ S Sbjct: 194 PEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQS 253 Query: 212 VGCIMAEMITGKTLFKGS--DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPEL- 268 +G M + + G + + D +K+ K P ++ ++ Sbjct: 254 LGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVV 313 Query: 269 ------EKKDFASILTNASPLAVNL 287 EK +A + N L +L Sbjct: 314 MALTYEEKPPYAMLRNNLEALLQDL 338 >5DMZ-A nrPDB Length = 365 Score = 66.5 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 49/289 (16%), Positives = 90/289 (31%), Gaps = 46/289 (15%) Query: 1 MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPV-------GSGAYGAVCSAV-----DGR 48 +S P + + + A + + ++ + G GA+ V A D + Sbjct: 34 LSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAK 93 Query: 49 TGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLV 108 K +K E + E RL M+H + + Y Sbjct: 94 NKQKFVLKVQKPANPWEFYIGTQLME-RLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSY 151 Query: 109 MPFMGT-DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE- 166 + +L K + + + + +ML + +H IIH D+KP N + Sbjct: 152 GTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLE 211 Query: 167 ----------LKILDFGLARQA-----DSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWS 211 L ++D G + + T T ++ E++ N + +D + Sbjct: 212 QDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFG 270 Query: 212 VGCIMAEMITGKT--------------LFKGSDHLDQLKEIMKVTGTPP 246 V + M+ G LF+ HLD E V P Sbjct: 271 VAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIP 319 >6M7Z-A nrPDB Length = 319 Score = 64.6 bits (156), Expect = 7e-11, Method: Composition-based stats. Identities = 40/224 (17%), Positives = 80/224 (35%), Gaps = 50/224 (22%) Query: 106 YLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC 165 Y+ P +G +++ + +Q L M+ L+ +H G++HR ++ + +V D Sbjct: 123 YIFHPLSKGLVGDMLETGR-SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 166 ELKILDFGLARQADSEMTGYVVTRWY-RAPEV--------ILNWMRYTQTVDIWSVGCIM 216 + + A +E +V APE+ L R+T D++S+G Sbjct: 182 TVVLGGLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV-- 239 Query: 217 AEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASI 276 + ++++ G L +D ++ Sbjct: 240 -----------------AFRNLVQLLGN---------------------GNLGPEDRGAV 261 Query: 277 LTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDE 320 + L L +KM+ + R T E + P FE L+ + E Sbjct: 262 RQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIE 305 >6EAS-A nrPDB Length = 308 Score = 63.0 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 38/276 (13%), Positives = 85/276 (30%), Gaps = 48/276 (17%) Query: 42 CSAVDGRTGAKVAIKKLYRPFQSELFAK---RAYRELRLLKHMRHENVIGLLDVFTPDET 98 +G ++A+ + + + +++ L + H+N + LL + Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHP 115 Query: 99 LDDFTDFYLVMPFM--GTDLGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHAAGI--IHR 152 +V + GT L + EKL + + L ++H R Sbjct: 116 FTRV----MVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALR 171 Query: 153 DLKPGNLAVNEDCELKILDFGL---ARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDI 209 + + + +D K+ D A+ +S + +P++ +Y Sbjct: 172 NFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELA----FSPDMEDIVRKY------ 221 Query: 210 WSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE 269 G ++ E++TG+ D P +V R + L EL Sbjct: 222 ---GMVLLEILTGRVPSSEDDG-------------PLENWVSRYFEGGMR-----LEELI 260 Query: 270 KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 + + ++ + D ++R E Sbjct: 261 DPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >4OAU-C nrPDB Length = 699 Score = 62.7 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 27/173 (15%), Positives = 63/173 (36%), Gaps = 14/173 (8%) Query: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP 61 + YR + K + + Y+ + G + + +VA+K Sbjct: 324 GAALKDLHRIYRPMIGKLKFFIDEKYKIADT----SEGGIYLGFYEK--QEVAVKTF--- 374 Query: 62 FQSELFAKRAYRELRLLKHMR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM 120 + RA RE+ L+ R + +++ + L D+ + Sbjct: 375 ---CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGE 431 Query: 121 KHEKLGEDRIQFLVYQMLKGLRYIH-AAGIIHRDLKPGNLAVNEDCELKILDF 172 E ++ + ++ + K ++ +H + G H+DL+P N+ ++ + DF Sbjct: 432 DVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 6/36 (16%), Positives = 13/36 (36%) Query: 281 SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 +L+ ++ R + L HP+F + Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWES 571 >5GZA-A nrPDB Length = 290 Score = 61.9 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 45/222 (20%), Positives = 77/222 (34%), Gaps = 48/222 (21%) Query: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHM 81 E+R+ R ++ +G GA V + G KVA+ L S+ +A L +L+ + Sbjct: 22 EIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVALSVL----SSDQYADDFLHGLSMLRAL 75 Query: 82 RHENVIGLLDVFTPDETL-DDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 + +V+ L+ V D ++ V+ + T L + + L + Sbjct: 76 QSSHVVTLVGVCEEDAVFVTEYHPLGSVLT-LDTTLAQERYRWRNSWHTRLQLAIDYVAF 134 Query: 141 LRYIHA--AGI--------IHRDLKPGNLAVNEDCELKILDFGLARQAD-------SEMT 183 L Y+H+ AGI +H+ L + D L LA D + Sbjct: 135 LAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLG 186 Query: 184 GYVV----TRWYRAPEVI-----------LNWMRYTQTVDIW 210 T + APE + Y + DIW Sbjct: 187 VKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6EWX-A nrPDB Length = 484 Score = 61.1 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 47/241 (19%), Positives = 73/241 (30%), Gaps = 74/241 (30%) Query: 110 PFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV-------- 161 F+ + ++ E R+ FL+ Q+ GL ++ GIIHRDL NL + Sbjct: 192 DFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSS 251 Query: 162 ---------------------------------NEDCELKILDFGLARQADSEMTGYVVT 188 L I +F A+Q T Sbjct: 252 PGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQK 311 Query: 189 R--WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 246 + APE++ + D + G ++ E++ P Sbjct: 312 KSQARLAPEIVSASQY--RKFDEFQTGILIYELL-----------------------HQP 346 Query: 247 AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEAL 306 F R Q E + LP L L+ SP L +L D +R+ GEA Sbjct: 347 NPFEVRAQLRERDYRREDLPPLPT------LSLYSPGLQQLAHLLLEADPIKRIRIGEAK 400 Query: 307 A 307 Sbjct: 401 R 401 >5GZ9-A nrPDB Length = 305 Score = 60.7 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 80/250 (32%), Gaps = 57/250 (22%) Query: 2 SSPPPARSGFYRQEVT--KTAW----EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAI 55 + G++R + W E+R R L+ VG GA V + KVA+ Sbjct: 5 ADSRRCPPGYFRMGRMRQCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKE--HKVAL 62 Query: 56 KKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-T 114 +L R E L++LK ++ E+V+ L+ D T ++ + Sbjct: 63 SRLTRLEMKE----DFLHGLQMLKSLQSEHVVTLVGYCEEDGT--------ILTEYHPLG 110 Query: 115 DLGKLMKHEKLG-------EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGN--------L 159 L L + +L L + + + Y+H + + R + N Sbjct: 111 SLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQY 170 Query: 160 AVNEDCELK--------ILDFGLARQADSEMTGYVVTRWYRAPEVILNWM---------- 201 + + + ++D + APE + + Sbjct: 171 LLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHG--DFVAPEQLWPYGEDTPFQDDLM 228 Query: 202 -RYTQTVDIW 210 Y + VDIW Sbjct: 229 PSYNEKVDIW 238 >3ENH-A nrPDB Length = 540 Score = 57.7 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 38/185 (20%), Positives = 76/185 (41%), Gaps = 26/185 (14%) Query: 12 YRQEVTKTAW--EVRAVYRDL--QPVGSGAYGAVCSAVDGRTGAKVAIK-KLYRPFQSEL 66 YR ++ + W E++ R + +G GA + D V IK ++ + ++ E Sbjct: 319 YRTDMVEVNWIKEIKGKKRKIPEHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDER 376 Query: 67 FAKRAY-----RELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMK 121 + RE R L ++ + P D + ++M ++ L K + Sbjct: 377 LDENIRKSRTAREARYLA------LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVI 430 Query: 122 HEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 + L + Y++ + + +H +IH DL N ++D L I+DFGL + ++ + Sbjct: 431 EDNLD------IAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLD 482 Query: 182 MTGYV 186 V Sbjct: 483 EDKAV 487 >4AZW-A nrPDB Length = 471 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 53/145 (36%), Gaps = 27/145 (18%) Query: 38 YGA--VCS--AVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH----MRHENVIGL 89 +G VC D G + +S+ + E++ L V+ Sbjct: 258 FGEDYVCKFFYYDMPHG-------ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA- 309 Query: 90 LDVFTPDETLDDFTDFYLVMP-FMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 ++ +LVM G L ++ + E + ++ +L+ L + G Sbjct: 310 --------HGENAQSGWLVMEKLPGRLLSDMLAAGE--EIDREKILGSLLRSLAALEKKG 359 Query: 149 IIHRDLKPGNLAVNEDCELKILDFG 173 H D++P N+ V+ +++DFG Sbjct: 360 FWHDDVRPWNVMVDARQHARLIDFG 384 >4CYJ-A nrPDB Length = 438 Score = 55.7 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 59/150 (39%), Gaps = 23/150 (15%) Query: 38 YGA---VCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFT 94 +G V A + R G A+++L K ++ K +++ +++ + +VFT Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 95 PDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--------------GEDRIQFLVYQMLKG 140 E F D L+ + L K ++ E+ I + Q+ Sbjct: 123 TRE----FGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANA 178 Query: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKIL 170 L+ IH+ + R L+P + + + +++ Sbjct: 179 LKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >4AZV-A nrPDB Length = 569 Score = 55.3 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 53/145 (36%), Gaps = 27/145 (18%) Query: 38 YGA--VCS--AVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH----MRHENVIGL 89 +G VC D G + +S+ + E++ L V+ Sbjct: 258 FGEDYVCKFFYYDMPHG-------ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA- 309 Query: 90 LDVFTPDETLDDFTDFYLVMP-FMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 ++ +LVM G L ++ + E + ++ +L+ L + G Sbjct: 310 --------HGENAQSGWLVMEKLPGRLLSDMLAAGE--EIDREKILGSLLRSLAALEKQG 359 Query: 149 IIHRDLKPGNLAVNEDCELKILDFG 173 H D++P N+ V+ +++DFG Sbjct: 360 FWHDDVRPWNVMVDARQHARLIDFG 384 >4WWA-A nrPDB Length = 261 Score = 54.6 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 59/173 (34%), Gaps = 32/173 (18%) Query: 29 DLQPVGSGAYGAV-------CSAVDGRTGAKVAIK-----KLYRPFQSELFAK-RAYREL 75 D+ P+ GA V + K IK + P + K R E Sbjct: 18 DIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNES 77 Query: 76 RLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL-----------GKLMKHEK 124 RLL + +I + P D + ++ + F+G DL M + Sbjct: 78 RLLAKL---YLIP--GLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 Query: 125 LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDC---ELKILDFGL 174 D + + ++ + + +H H DL N+ + D ++DFGL Sbjct: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >5VE6-A nrPDB Length = 492 Score = 52.6 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 16/35 (45%), Positives = 22/35 (62%) Query: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV 161 E R+ FL+ Q+ GL ++ GIIHRDL NL + Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 36.1 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 37/116 (31%), Gaps = 31/116 (26%) Query: 192 RAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQ 251 APE++ + D + G ++ E++ P F Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELL-----------------------HQPNPFEV 359 Query: 252 RLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 R Q E + LP L L+ SP L +L D +R+ GEA Sbjct: 360 RAQLRERDYRQEDLPPLPA------LSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >6BHC-A nrPDB Length = 438 Score = 51.9 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 72/220 (32%), Gaps = 53/220 (24%) Query: 108 VMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV------ 161 V F+ L + K L E ++ L+ Q+ GL ++ + H DL+ NL + Sbjct: 158 VADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPG 217 Query: 162 ---------------NEDCELKILDFGLARQADSEMTGYVVTRWYR-APEVILNWMRYTQ 205 + L + +F A+Q + ++ R APE+I + Sbjct: 218 GTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQY--K 275 Query: 206 TVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 D + G ++ EM+ F ++ E K Sbjct: 276 KCDEFQTGILIYEMLHLPNPFD--------------------------ENPELKEREYTR 309 Query: 266 PELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEA 305 +L + F S S L +L + +R+ +A Sbjct: 310 ADLPRIPFRSPY---SRGLQQLASCLLNPNPSERILISDA 346 >6G38-A nrPDB Length = 357 Score = 51.1 bits (121), Expect = 7e-07, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 62/209 (29%), Gaps = 54/209 (25%) Query: 2 SSPPPARSGFYRQEVTKTAWE---------VRAVYRDLQPVGSGAYGAVCSAVDGRTGAK 52 S Y Q + + + + + + +G G +G V + T Sbjct: 9 SGVDLGTENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--P 66 Query: 53 VAIKKL------YRPFQSELFAKRAYRELRLLKH-----------------MRHENVIG- 88 VAIK + + + E+ + K + + + Sbjct: 67 VAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQG 126 Query: 89 -----LLDVF------------TPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQ 131 LL + PD DD L F G DL + M+ + + Sbjct: 127 SYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQ-MRTKLSSLATAK 185 Query: 132 FLVYQMLKGLRYIH-AAGIIHRDLKPGNL 159 +++Q+ L + HRDL GN+ Sbjct: 186 SILHQLTASLAVAEASLRFEHRDLHWGNV 214 >3BYV-A nrPDB Length = 377 Score = 50.7 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 66/185 (35%), Gaps = 16/185 (8%) Query: 111 FMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKIL 170 F L H+ L L Q+++ L +H G++H L+P ++ +++ + + Sbjct: 189 FGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT 248 Query: 171 DF-GLARQADSEMTGYVVTRWYRAPEVILNWMRY----------TQTVDIWSVGCIMAEM 219 F L R D V+R + PE+ T + D W++G ++ + Sbjct: 249 GFEHLVR--DGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWI 306 Query: 220 ITGKTLFKGSDHLDQLKEIMKVTGTPPAE---FVQRLQSDEAKNYMKGLPELEKKDFASI 276 L + I + P ++ ++ + L +E ++ + Sbjct: 307 WCADLPITKDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQL 366 Query: 277 LTNAS 281 T S Sbjct: 367 RTELS 371 >2W1Z-A nrPDB Length = 368 Score = 49.2 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 49/322 (15%), Positives = 104/322 (32%), Gaps = 58/322 (18%) Query: 16 VTKTAWEVRAVYRDLQPVGS--------------GAYGAVCSAVDGRTGA--KV------ 53 V+ W +R +G G+Y A D TG +V Sbjct: 36 VSTALWRNEQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFT 94 Query: 54 ------AIK---------KLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDET 98 AIK +L R +++ AK R + + ++ ++ V + Sbjct: 95 ERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERD 154 Query: 99 LDDFTDFYLV------MPFMGT-DLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIH 151 + + F+L + +G L H+ L L Q+++ + G++H Sbjct: 155 MWVLSRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVH 214 Query: 152 RDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM-RY------- 203 D + N+ +++ + + F + + + R + PE M Y Sbjct: 215 ADFQVRNILLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTL 273 Query: 204 -TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE---FVQRLQSDEAK 259 T D W++G + + L ++ I + P ++ + Sbjct: 274 MTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKE 333 Query: 260 NYMKGLPELEKKDFASILTNAS 281 + + L +E ++ + T S Sbjct: 334 DRLLPLQAMETSEYEQLRTELS 355 >3Q60-A nrPDB Length = 371 Score = 48.0 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 53/320 (16%), Positives = 99/320 (30%), Gaps = 52/320 (16%) Query: 28 RDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYREL-----RLL---- 78 + ++P+ G V D A+K ++ E RLL Sbjct: 65 KLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGESP 124 Query: 79 KHMRHENVIGL------------LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL- 125 + R + L +P + ++ L+MP DL L Sbjct: 125 EEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLDFV 184 Query: 126 -------GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 G + L Q+++ + + G++H P NL + D L + D + Sbjct: 185 YVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKV 244 Query: 179 DSEMTGYVVTRWYRAPEVI-LNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKE 237 + V Y E + + +T ++ W +G + + F + Sbjct: 245 GTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFG------LVTP 298 Query: 238 IMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAE 297 +K + P+ V S + LP+ K L+ + L D Sbjct: 299 GIKGSWKRPSLRVPGTDSLAFGS-CTPLPDFVKT---------------LIGRFLNFDRR 342 Query: 298 QRVTAGEALAHPYFESLHDT 317 +R+ EA+ P F L + Sbjct: 343 RRLLPLEAMETPEFLQLQNE 362 >4BWP-A nrPDB Length = 448 Score = 45.3 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 52/167 (31%), Gaps = 42/167 (25%) Query: 42 CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDD 101 A TG K L R L + + + + K ++H NV+ L +VFT D Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGD- 122 Query: 102 FTDFYLVMPFMGTDLGKLMKH---------------------------------EKLGED 128 LV + L K+ L E Sbjct: 123 -NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEA 181 Query: 129 RIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNED----CELKILD 171 I ++ Q+ GL+ IH AG+ + L P + V I D Sbjct: 182 TIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3DZO-A nrPDB Length = 413 Score = 45.3 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 50/332 (15%), Positives = 98/332 (29%), Gaps = 78/332 (23%) Query: 16 VTKTAWEVRAVYRDLQPVGS-------GAYGAVC---------SAVDGRTGAKV------ 53 V+ + W +R +G G V A D TG Sbjct: 56 VSTSLWNTGQPFRVESELGERPRTLVRG---TVLGQEDPYAYLEATDQETGESFEVHVPY 112 Query: 54 --------AIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVF------------ 93 AIK++ E+ R R ++ K + + L +F Sbjct: 113 FTERPPSNAIKQMK----EEVLRLRLLRGIKNQKQAK----VHLRFIFPFDLVKDPQKKK 164 Query: 94 -------TPDETLDDFTDFYLVM-----PFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGL 141 D + Y M F L H+ L L Q+++ L Sbjct: 165 MIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLL 224 Query: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWM 201 +H G++H L+P ++ +++ + + F + + + R + PE M Sbjct: 225 ASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIG-RGFAPPETTAERM 283 Query: 202 -RY--------TQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAE---F 249 + T D W++G + + L + I + P Sbjct: 284 LPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQPVRAL 343 Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 ++ ++ + L +E ++ + T S Sbjct: 344 LEGFLRYPKEDRLLPLQAMETPEYEQLRTELS 375 >4CZY-B nrPDB Length = 429 Score = 44.6 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 23/142 (16%), Positives = 51/142 (35%), Gaps = 18/142 (12%) Query: 42 CSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDD 101 A + + G A++++ K + K + + N++ + + FT + Sbjct: 61 YKAQNNKNGRHFALRRI--EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTE--FFG 116 Query: 102 FTDFYLVMPF--MGTDLGK-----------LMKHEKLGEDRIQFLVYQMLKGLRYIHAAG 148 + V F + L L K+ E+ + V Q+ L IH A Sbjct: 117 DSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAK 176 Query: 149 IIHRDLKPGNLAVNEDCELKIL 170 + R L+ + + E+ +++ Sbjct: 177 LAARCLELSKI-IWENNRIRLA 197 >6G5I-z nrPDB Length = 568 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 45/101 (44%), Gaps = 4/101 (3%) Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL--GKLMKHEKLGEDRIQFLVYQMLKGLR 142 N+I L P LVM F+G D L+K+ +L E + + L Q+++ +R Sbjct: 253 NLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMR 312 Query: 143 YIHA-AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM 182 ++ A ++H DL N + + I+D + + D Sbjct: 313 RMYQDARLVHADLSEFN-MLYHGGGVYIIDVSQSVEHDHPH 352 >4OTP-A nrPDB Length = 352 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 45/101 (44%), Gaps = 4/101 (3%) Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL--GKLMKHEKLGEDRIQFLVYQMLKGLR 142 N+I L P LVM F+G D L+K+ +L E + + L Q+++ +R Sbjct: 111 NLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMR 170 Query: 143 YIHA-AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM 182 ++ A ++H DL N + + I+D + + D Sbjct: 171 RMYQDARLVHADLSEFN-MLYHGGGVYIIDVSQSVEHDHPH 210 >5YK0-A nrPDB Length = 452 Score = 38.4 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 31/177 (17%), Positives = 54/177 (30%), Gaps = 53/177 (29%) Query: 39 GAVCSAVDGRTGAKVAIKKLYRPFQSELFA---KRAYRELRLLKHM-------------- 81 G V A+ G +VA+K + P E K R + +LK + Sbjct: 146 GQVHKAIW-SDGREVAVK-IQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELV 203 Query: 82 ------------------------RHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLG 117 H F + + G + Sbjct: 204 ERTEMELDYRLEAANQRAFAKAYHDHPR-------FQVPHVVASAPKVVIQEWIEGVPMA 256 Query: 118 KLMKHEKLGE-DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFG 173 ++++H + D I L+ ++ G++H D PGN + D + I+DFG Sbjct: 257 EIIRHGTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >1TQM-A nrPDB Length = 282 Score = 38.0 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 32/168 (19%), Positives = 62/168 (36%), Gaps = 31/168 (18%) Query: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAI---------KKLYRPFQ------SELFAKRAYR 73 + +G G AV + + G V KK+ S L + A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 74 ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFL 133 E R L+ ++ + P + ++M + D +L + D + + Sbjct: 154 EFRALQKLQ--------GLAVPKVYAWEGNA--VLMELI--DAKELYRVRVENPDEVLDM 201 Query: 134 VYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE 181 +L+ + + GI+H DL N+ V+E+ + I+DF + + E Sbjct: 202 ---ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEE 245 >6FAI-l nrPDB Length = 425 Score = 36.5 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 59/195 (30%), Gaps = 40/195 (20%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKK-----------------LYR 60 KT VY +G G + D +V +K L + Sbjct: 86 KTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKK 144 Query: 61 PFQS----ELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDL 116 Q L A +E + + + + F E D+ +VM + Sbjct: 145 SNQGANWMHLSRLAANKEYQFMSMLYSKG-------FKVPEPFDNSRHI-VVMELIEGYP 196 Query: 117 GKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE------DCELKIL 170 + ++ K L+ ++ + +G+IH D N+ + + DC ++ Sbjct: 197 MRRLRKHKNIPKLYSDLMCFIVD----LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVI 252 Query: 171 DFGLARQADSEMTGY 185 DF + Y Sbjct: 253 DFPQCISIQHQDADY 267 >6G18-v nrPDB Length = 552 Score = 36.1 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 40/103 (38%), Gaps = 14/103 (13%) Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDR 129 A +E +K L + P D+ +VM + G L ++ ED Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHH----VEDP 205 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF 172 + ++ + + G+IH D NL ++E + ++DF Sbjct: 206 ASVY-DEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 35.3 bits (80), Expect = 0.047, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 40/103 (38%), Gaps = 14/103 (13%) Query: 71 AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKHEKLGEDR 129 A +E +K L + P D+ +VM + G L ++ ED Sbjct: 158 AMKEFAYMK--------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHH----VEDP 205 Query: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDF 172 + ++ + + G+IH D NL ++E + ++DF Sbjct: 206 ASVY-DEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 34.9 bits (79), Expect = 0.060, Method: Composition-based stats. Identities = 29/174 (16%), Positives = 59/174 (33%), Gaps = 23/174 (13%) Query: 3 SPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF 62 + ++ F + A V + +G G+ + V+ + LY+ + Sbjct: 19 TSTIIQTPFPFENNNSHAGIVTEP-ILGKLIGQGSTAEIFEDVNDSS-------ALYKKY 70 Query: 63 QSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDET---LDDFTDFYLVMPFMGTDLGKL 119 E+ + L + F DE + D YL M + Sbjct: 71 DLIGNQYNEILEMAWQES-------ELFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSD 123 Query: 120 MKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE-LKILDF 172 + + ++ + + K ++ IIH DL GN+ +++ E L +DF Sbjct: 124 IDTADIPDNIESLYLQLICK----LNELSIIHYDLNTGNMLYDKESESLFPIDF 173 >1F8S-A nrPDB Length = 498 Score = 33.4 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 41/103 (39%), Gaps = 12/103 (11%) Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + V+ L+ + K++ + SP AV+++ +L D+ V+ E+L Sbjct: 163 KVVEELKRTNCSYILNKYDTYSTKEYLIKEGDLSPGAVDMIGDLLNEDSGYYVSFIESLK 222 Query: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLS 350 H + Y+ FD++ +D+ Y+++ Sbjct: 223 H------------DDIFAYEKRFDEIVDGMDKLPTAMYRDIQD 253 >6DFL-A nrPDB Length = 259 Score = 33.4 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 28/194 (14%), Positives = 61/194 (31%), Gaps = 26/194 (13%) Query: 18 KTAWEVRAVYRDLQPVGSGAYGAVCSAVDGR-------TGAKVAIKK---------LYRP 61 K W R + ++ + G V ++GR G +K Sbjct: 10 KRLWNGRDPFEAVEAL----QGKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNL 65 Query: 62 FQSELFAKRAYRELRLLKHMRHENVIGLLDV-FTPDETLDDFTDFYLVMPFMG-----TD 115 ++L A +E + ++ + V + V + + ++V + Sbjct: 66 LTAKLPVLGARQEWQAIRRLHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEV 125 Query: 116 LGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 + + + LV + + + +H AG+ HRD + ++ D + DF L+ Sbjct: 126 FSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDKPVSADDFRLS 185 Query: 176 RQADSEMTGYVVTR 189 T Sbjct: 186 VIDLHRAQTRDATP 199 >3AOI-E nrPDB Length = 99 Score = 32.6 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 43/90 (47%), Gaps = 10/90 (11%) Query: 288 LEKML-VLDAEQRVT------AGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEW 340 ++K+ ++D++ R+T A + L H + ++ + E+ P++Q + FDD + Sbjct: 6 IDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAM 65 Query: 341 KRVTYKEVL---SFKPPRQLGARVSKETPL 367 K + ++ + P +L + + P+ Sbjct: 66 KELLTGRLVFGENLVPEDRLQKEMERLYPV 95 >5N28-B nrPDB Length = 444 Score = 32.2 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 29/81 (35%), Gaps = 3/81 (3%) Query: 85 NVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG---EDRIQFLVYQMLKGL 141 N+ LL T E L +V ++ T +M E F + + Sbjct: 174 NIASLLGAPTNLEGLGYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 142 RYIHAAGIIHRDLKPGNLAVN 162 +H G+ ++ L NL ++ Sbjct: 234 ERLHLLGLAYQGLNADNLVID 254 >4LXF-A nrPDB Length = 620 Score = 31.5 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 42/191 (21%), Positives = 71/191 (37%), Gaps = 30/191 (15%) Query: 171 DFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKG-S 229 DFG A ++ T + +Y EV++ + + D G +G Sbjct: 49 DFGSAAALPADPTWFKHAVFY---EVLV-RAFFDASAD-------------GSGDLRGLI 91 Query: 230 DHLD--QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEK-KDFASILTNASPLAVN 286 D LD Q I + P + R + +++ K LPE DF +++ A + Sbjct: 92 DRLDYLQWLGIDCIWLPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVALVDAAHRRGIR 151 Query: 287 LLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYK 346 ++ LV++ T+ +HP+F+ D P Y S T V + Sbjct: 152 IITD-LVMNH----TSE---SHPWFQESRRDPDGPYGDYYVWSDTSERYTDARIIFVDTE 203 Query: 347 EVL-SFKPPRQ 356 E SF P R+ Sbjct: 204 ESNWSFDPVRR 214 >6EF6-A nrPDB Length = 354 Score = 31.1 bits (69), Expect = 0.80, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 148 GIIHRDLKPGNLAVNEDC---ELKILDF 172 G+IH DL+ NL V+ + ++DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >3KVE-A nrPDB Length = 486 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 39/99 (39%), Gaps = 12/99 (12%) Query: 250 VQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHP 309 V+ L+ + K++ N SP AV+++ +L D+ V+ E+L H Sbjct: 165 VKDLKRTNCSYILNKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKH- 223 Query: 310 YFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEV 348 + Y+ FD++ +D+ Y+ + Sbjct: 224 -----------DDIFAYEKRFDEIVGGMDQLPTSMYRAI 251 >1REO-A nrPDB Length = 486 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 40/101 (39%), Gaps = 12/101 (11%) Query: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALA 307 + V+ L+ + K++ N SP AV+++ ++ D+ V+ E+L Sbjct: 163 KVVEELKRTNCSYILNKYDTYSTKEYLLKEGNLSPGAVDMIGDLMNEDSGYYVSFPESLR 222 Query: 308 HPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEV 348 H + Y+ FD++ +D+ Y+ + Sbjct: 223 H------------DDIFAYEKRFDEIVGGMDKLPTSMYRAI 251 >1HQM-E nrPDB Length = 99 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 33/64 (51%), Gaps = 7/64 (10%) Query: 288 LEKML-VLDAEQRVT------AGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEW 340 ++K+ ++D++ R+T A + L H + ++ + E+ P+++ + +DD + Sbjct: 6 IDKLFGMVDSKYRLTVVVAKRAQQLLRHRFKNTVLEPEERPKMRTLEGLYDDPNAVTWAM 65 Query: 341 KRVT 344 K + Sbjct: 66 KELL 69 >3AI7-A nrPDB Length = 831 Score = 30.3 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 11/58 (18%), Positives = 19/58 (32%), Gaps = 2/58 (3%) Query: 299 RVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQ 356 R++ E H +F + E D+ + R E + E+ K Q Sbjct: 227 RISDEEL--HEFFHGMGYEPYEFVAGFDDEDHMSIHRRFAELWETIWDEICDIKATAQ 282 >5H2T-A nrPDB Length = 601 Score = 29.5 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 37/102 (36%), Gaps = 9/102 (8%) Query: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPEL-EKKDFASILTNASPLAVNLLEKML 292 Q I + P + R + +Y K LPE + DF ++ A + ++ L Sbjct: 58 QWLGIDCIWLLPIYQSPLRDGGYDISDYTKILPEFGDLGDFVELVDEAHRRGIRVIAD-L 116 Query: 293 VLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVD 334 V++ HP+F++ D P Y S D Sbjct: 117 VMNHTSD-------QHPWFQASRTDPDGPYGDFYMWSDTDDK 151 >5LJ3-H nrPDB Length = 591 Score = 29.5 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 30/66 (45%), Gaps = 6/66 (9%) Query: 117 GKLMKHEKLGEDRIQFLVYQMLK--GLRYIHAAGIIHRDLKPGNLAVNEDCELK-ILDFG 173 + +K ++ + I+ V ++ + + + HRDL N+ + D K ++DF Sbjct: 8 DEDIKFQRENWEMIRSHVSPIISNLTMDNLQES---HRDLFQVNILIGRDIICKNVVDFT 64 Query: 174 LARQAD 179 L +Q Sbjct: 65 LNKQNG 70 >4K92-A nrPDB Length = 273 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 23/62 (37%), Gaps = 2/62 (3%) Query: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140 +RH ++ L+ V T + T F+ L + H E I L + KG Sbjct: 158 IRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL--ERHISVLAETIKKG 215 Query: 141 LR 142 + Sbjct: 216 IH 217 >1OTJ-A nrPDB Length = 283 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 26/65 (40%), Gaps = 3/65 (4%) Query: 300 VTAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGA 359 + A EAL+ P+ + L E +K SF + E + ++E ++ PP Sbjct: 132 IAAYEALSVPFRQLLSGLRAEHDFRK---SFPEYKYRKTEEEHQRWREAVAKNPPLLHPV 188 Query: 360 RVSKE 364 + Sbjct: 189 VRTHP 193 >6HV9-A nrPDB Length = 914 Score = 28.8 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 48/136 (35%), Gaps = 19/136 (13%) Query: 55 IKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFT-----PDETLDDFTDFYLVM 109 I KLYR E + R L+ L ++ + LL P L + Sbjct: 259 ISKLYRRLSQETTKLKEERGLQFLLLLQSPFITKLLGTIRLLNQMPIVKLSLNEVLLPQL 318 Query: 110 PFMGTDLGKLMKHEKLGEDRIQFLVY-----QM------LKGLRYIHAAGIIH-RDLKPG 157 + T L KL+ H I L+ + L + YI +++ R LK Sbjct: 319 NWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDYI--IDVLYARKLKKE 376 Query: 158 NLAVNEDCELKILDFG 173 N+ + + + + D G Sbjct: 377 NIVLWWNEKAPLPDHG 392 >1TWL-A nrPDB Length = 186 Score = 28.0 bits (61), Expect = 7.0, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 19/43 (44%), Gaps = 5/43 (11%) Query: 307 AHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 PYF+ D +D P+ D++ +K + KE++ Sbjct: 120 EDPYFKDWKDIDDVPKA-----FLDEIAHFFKRYKELQGKEII 157 >1UDE-A nrPDB Length = 195 Score = 27.6 bits (60), Expect = 8.4, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 18/43 (41%), Gaps = 5/43 (11%) Query: 307 AHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVL 349 PYF+ D D P+ D++ +K + KE++ Sbjct: 129 EDPYFKDWKDISDVPKA-----FLDEIAHFFKRYKELEGKEII 166 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.145 0.439 Lambda K H 0.267 0.0443 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,641,407 Number of Sequences: 36641 Number of extensions: 677565 Number of successful extensions: 6068 Number of sequences better than 10.0: 514 Number of HSP's better than 10.0 without gapping: 933 Number of HSP's successfully gapped in prelim test: 57 Number of HSP's that attempted gapping in prelim test: 2022 Number of HSP's gapped (non-prelim): 1233 length of query: 367 length of database: 10,336,785 effective HSP length: 98 effective length of query: 269 effective length of database: 6,745,967 effective search space: 1814665123 effective search space used: 1814665123 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)