BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P53323 (261 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4WWA-A nrPDB 545 e-156 3ENH-A nrPDB 94 6e-20 3MA6-A nrPDB 41 4e-04 5JN2-A nrPDB 40 0.001 5DBX-A nrPDB 34 0.049 2W96-B nrPDB 34 0.068 3HKO-A nrPDB 34 0.077 3DAK-A nrPDB 33 0.089 3DLS-A nrPDB 33 0.095 3MIA-A nrPDB 33 0.096 2ZFU-A nrPDB 33 0.13 4YZB-A nrPDB 33 0.15 3Q5I-A nrPDB 33 0.17 6BFN-A nrPDB 33 0.18 4XHH-A nrPDB 32 0.21 6FD3-A nrPDB 32 0.24 4RGJ-A nrPDB 32 0.24 3Q53-A nrPDB 32 0.26 3M42-A nrPDB 32 0.32 5TQX-A nrPDB 32 0.33 5J0A-A nrPDB 32 0.35 3LIJ-A nrPDB 32 0.36 3DFA-A nrPDB 32 0.38 4XHL-A nrPDB 31 0.42 5UIU-A nrPDB 31 0.67 3NCG-A nrPDB 30 0.70 3FXW-A nrPDB 30 0.76 1KOA-A nrPDB 30 0.79 3UTO-A nrPDB 30 0.92 5HI2-A nrPDB 30 0.99 3COM-A nrPDB 30 1.0 2KHZ-A nrPDB 30 1.1 4L00-A nrPDB 30 1.2 4WNO-A nrPDB 30 1.3 4AU8-A nrPDB 30 1.4 4QMW-A nrPDB 30 1.4 4KXN-A nrPDB 30 1.5 4KIK-B nrPDB 29 1.6 4APC-A nrPDB 29 1.7 4G3E-A nrPDB 29 1.8 2XIK-A nrPDB 29 1.9 6AO5-A nrPDB 29 2.6 3F3Z-A nrPDB 29 2.6 6CKI-A nrPDB 28 2.7 4LG4-A nrPDB 28 2.8 4NST-A nrPDB 28 3.2 4MLQ-A nrPDB 28 3.4 5Y86-A nrPDB 28 3.6 6HIV-BB nrPDB 28 4.0 5I2K-B nrPDB 28 4.2 2RSV-A nrPDB 28 4.7 5HIE-A nrPDB 28 4.8 2LAV-A nrPDB 28 4.9 3DH7-A nrPDB 28 5.0 3QA8-A nrPDB 28 5.2 4JXF-A nrPDB 28 5.5 2F57-A nrPDB 28 5.7 5UU1-A nrPDB 28 5.8 5XGF-A nrPDB 27 6.2 3NRE-A nrPDB 27 7.2 1XB4-A nrPDB 27 7.2 4MVF-A nrPDB 27 8.0 >4WWA-A nrPDB Length = 261 Score = 545 bits (1404), Expect = e-156, Method: Compositional matrix adjust. Identities = 261/261 (100%), Positives = 261/261 (100%) Query: 1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR 60 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR Sbjct: 1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR 60 Query: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS 120 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS Sbjct: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS 120 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL Sbjct: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 Query: 181 IDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKL 240 IDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKL Sbjct: 181 IDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKL 240 Query: 241 KEVTKRFEEVRLRGRKRSMLG 261 KEVTKRFEEVRLRGRKRSMLG Sbjct: 241 KEVTKRFEEVRLRGRKRSMLG 261 >3ENH-A nrPDB Length = 540 Score = 94.0 bits (232), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 70/213 (32%), Positives = 104/213 (48%), Gaps = 42/213 (19%) Query: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKY--IIKYRPPKRYRHPQIDQALTKHRTLNESRL 79 I +GAEA + +DS+ + IIK R K YR ++D+ + K RT E+R Sbjct: 344 IGKGAEADI-----------KRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARY 392 Query: 80 LAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 LA L G+ P + D N I + ++ L D++ Sbjct: 393 LA-LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLA--------------------KDVIE 431 Query: 140 TTLR---KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKG 196 L K+G +G LH ND H DLT+SN + +D ++IDFGLG +SNL EDK Sbjct: 432 DNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD-----LYIIDFGLGKISNLDEDKA 486 Query: 197 VDLYVLERAILSTHSKHAEKYNAWIMEGFEEVY 229 VDL V ++A+LSTH + ++ +EG++ VY Sbjct: 487 VDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVY 519 >3MA6-A nrPDB Length = 298 Score = 41.2 bits (95), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 16/163 (9%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFS 120 I + K +T ES LL ++ L+ L P ++ + G+ +L +GE GG F Sbjct: 65 ISKRQVKQKTDKES-LLREVQLLKQLDHPNIMKLYEFFEDKGYFYL--VGEVYTGGELFD 121 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + + + D A +R+V I +H N H DL N++L + Sbjct: 122 EIISRKRFSEVD-----AARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRI 176 Query: 181 IDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 IDFGL + S ++DK Y + +L H + EK + W Sbjct: 177 IDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVW 217 >5JN2-A nrPDB Length = 525 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 16/163 (9%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFS 120 I + K +T ES LL ++ L+ L P ++ + G+ +L +GE GG F Sbjct: 100 ISKRQVKQKTDKES-LLREVQLLKQLDHPNIMKLYEFFEDKGYFYL--VGEVYTGGELFD 156 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + + + D A +R+V I +H N H DL N++L + Sbjct: 157 EIISRKRFSEVDA-----ARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRI 211 Query: 181 IDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 IDFGL + S ++DK Y + +L H + EK + W Sbjct: 212 IDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVW 252 >5DBX-A nrPDB Length = 328 Score = 34.3 bits (77), Expect = 0.049, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 3/51 (5%) Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 ++AT L++V + LH N H DL + NI+L DG + + DFG+ + Sbjct: 118 IIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDG---SVQIADFGVSA 165 >2W96-B nrPDB Length = 306 Score = 33.9 bits (76), Expect = 0.068, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%) Query: 117 HGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQ----IGLLHWNDYCHGDLTSSNIVLVRD 172 H +L+ +L D+ P L A T++ + RQ + LH N H DL NI++ Sbjct: 92 HVDQDLRTYL---DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG 148 Query: 173 GARWTPHLIDFGLGSV 188 G T L DFGL + Sbjct: 149 G---TVKLADFGLARI 161 >3HKO-A nrPDB Length = 345 Score = 33.9 bits (76), Expect = 0.077, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 45/113 (39%), Gaps = 16/113 (14%) Query: 117 HGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARW 176 HGF +F+ L++ +R++ + LH CH D+ N + + + + Sbjct: 155 HGFRESLDFVQR------EKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKS-F 207 Query: 177 TPHLIDFGL---------GSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 L+DFGL G + G +V + +T+ + K +AW Sbjct: 208 EIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAW 260 >3DAK-A nrPDB Length = 290 Score = 33.5 bits (75), Expect = 0.089, Method: Compositional matrix adjust. Identities = 18/50 (36%), Positives = 28/50 (56%), Gaps = 3/50 (6%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 +AT LR+V + LH N H D+ + NI+L DG + + DFG+ + Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDG---SVQIADFGVSA 164 >3DLS-A nrPDB Length = 335 Score = 33.5 bits (75), Expect = 0.095, Method: Compositional matrix adjust. Identities = 25/70 (35%), Positives = 35/70 (50%), Gaps = 7/70 (10%) Query: 117 HGFSNLKNFLWMHDQDPYSD--LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA 174 HG S L F ++ D+ P D L + R++ +G L D H D+ NIV+ D Sbjct: 111 HG-SGLDLFAFI-DRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAED-- 166 Query: 175 RWTPHLIDFG 184 +T LIDFG Sbjct: 167 -FTIKLIDFG 175 >3MIA-A nrPDB Length = 351 Score = 33.5 bits (75), Expect = 0.096, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 35/71 (49%), Gaps = 10/71 (14%) Query: 137 LVATTLRKVGRQIGLL-------HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS 189 LV TL ++ R + +L H N H D+ ++N+++ RDG L DFGL Sbjct: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL---KLADFGLARAF 174 Query: 190 NLVEDKGVDLY 200 +L ++ + Y Sbjct: 175 SLAKNSQPNRY 185 >2ZFU-A nrPDB Length = 215 Score = 33.1 bits (74), Expect = 0.13, Method: Compositional matrix adjust. Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 19/130 (14%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGD--LTSS--NIVLVRDGARWTPHLIDFGLGSVSNL 191 D +A LR+ + L D+ GD L SS N V D A P + + V Sbjct: 56 DRIARDLRQ---RPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVP-- 110 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEVR 251 +ED+ VD+ V +++ T+ I + EE R G K+ EV+ RFE+VR Sbjct: 111 LEDESVDVAVFCLSLMGTN----------IRDFLEEANRVLKPGGLLKVAEVSSRFEDVR 160 Query: 252 LRGRKRSMLG 261 R + LG Sbjct: 161 TFLRAVTKLG 170 >4YZB-A nrPDB Length = 491 Score = 32.7 bits (73), Expect = 0.15, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 38/86 (44%), Gaps = 5/86 (5%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---VSNLVED 194 A +R+V I +H N H DL N++L +IDFGL + + ++D Sbjct: 132 AARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKD 191 Query: 195 KGVDLYVLERAILSTHSKHAEKYNAW 220 K Y + +L H + EK + W Sbjct: 192 KIGTAYYIAPEVL--HGTYDEKCDVW 215 >3Q5I-A nrPDB Length = 504 Score = 32.7 bits (73), Expect = 0.17, Method: Compositional matrix adjust. Identities = 34/154 (22%), Positives = 60/154 (38%), Gaps = 15/154 (9%) Query: 39 LPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLY----LIPGLCVPQL 94 L + K+ H + IK + Q D+ N + ++Y L+ L P + Sbjct: 54 LCKEKNGHSEKAIKV-----IKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNI 108 Query: 95 IAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLH 153 I D + + + E GG F + N + D A ++++ I LH Sbjct: 109 IKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDA-----ANIMKQILSGICYLH 163 Query: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 ++ H D+ NI+L + ++DFGL S Sbjct: 164 KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSS 197 >6BFN-A nrPDB Length = 342 Score = 32.7 bits (73), Expect = 0.18, Method: Compositional matrix adjust. Identities = 21/53 (39%), Positives = 25/53 (47%), Gaps = 5/53 (9%) Query: 142 LRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 L R I LH + HGD+ SSN++L R TP L DFGL S Sbjct: 131 LLGTARAIQFLHQDSPSLIHGDIKSSNVLL---DERLTPKLGDFGLARFSRFA 180 >4XHH-A nrPDB Length = 403 Score = 32.3 bits (72), Expect = 0.21, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 30/135 (22%) Query: 58 RYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLI---ACDPYNGFIWLEFLG---E 111 R RHPQ+D ESR+ YL G+ +P + YN + ++ LG E Sbjct: 43 RSRHPQLDY---------ESRVYK--YLSGGVGIPFIRWFGREGEYNAMV-IDLLGPSLE 90 Query: 112 DLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR 171 DL F + H + + ++ L+ + R + +H + H D+ N ++ Sbjct: 91 DL-----------FNYCHRKFSFKTVIMLALQMICR-VQYIHGRSFIHRDIKPDNFLMGV 138 Query: 172 DGARWTPHLIDFGLG 186 T H+IDFGL Sbjct: 139 GRRGSTVHVIDFGLS 153 >6FD3-A nrPDB Length = 300 Score = 32.0 bits (71), Expect = 0.24, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 +A R+ + + LH N H D+ S NI+L DG+ L DFG Sbjct: 120 IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV---KLTDFGF 164 >4RGJ-A nrPDB Length = 520 Score = 32.0 bits (71), Expect = 0.24, Method: Compositional matrix adjust. Identities = 41/186 (22%), Positives = 77/186 (41%), Gaps = 21/186 (11%) Query: 39 LPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD 98 L R K + +Y IK K + ++L + L L ++ + + +L Sbjct: 78 LSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVEL--------LKMLDHINIMKLYEFF 129 Query: 99 PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYC 158 N + +L + + GG F + + ++ D A ++++ I +H N+ Sbjct: 130 EDNNYYYL--VSDVYTGGELFDEIISRKRFYEIDA-----ARIIKQILSGITYMHKNNVV 182 Query: 159 HGDLTSSNIVL-VRDGARWTPHLIDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHA 214 H DL NI+L ++ +IDFGL + S ++DK Y + +L H + Sbjct: 183 HRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL--HGTYD 240 Query: 215 EKYNAW 220 EK + W Sbjct: 241 EKCDIW 246 >3Q53-A nrPDB Length = 306 Score = 32.0 bits (71), Expect = 0.26, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 +A R+ + + LH N H D+ S NI+L DG + L DFG Sbjct: 119 IAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDG---SVKLTDFGF 163 >3M42-A nrPDB Length = 299 Score = 31.6 bits (70), Expect = 0.32, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 42/104 (40%), Gaps = 4/104 (3%) Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 Y G L + E L GG FS +++ DQ + ++ +G I LH + H Sbjct: 84 YAGRKCLLIVMECLDGGELFSRIQD---RGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 160 GDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE-DKGVDLYVL 202 D+ N++ L DFG + + DK D++ L Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKETTGEKYDKSCDMWSL 184 >5TQX-A nrPDB Length = 655 Score = 31.6 bits (70), Expect = 0.33, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 22/47 (46%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + + L +G I LH N H DL NIVL G + +ID G Sbjct: 116 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLG 162 >5J0A-A nrPDB Length = 300 Score = 31.6 bits (70), Expect = 0.35, Method: Compositional matrix adjust. Identities = 40/169 (23%), Positives = 70/169 (41%), Gaps = 24/169 (14%) Query: 14 TPDVDIAPISQGAEAIVFTTTTHPYL----PRAKDSHQKYIIKYRPPKRYRHPQIDQALT 69 TP ++I P S + + F T + YL PR SH + +K P H Sbjct: 3 TPTINI-PASPFMQKLGFGTGVNVYLMKRSPRGL-SHSPWAVKKINPICNDH-------- 52 Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLE----FLGEDLPGGHGFSNLKNF 125 +R++ + RL+ + ++ L P ++ Y F L + G ++L Sbjct: 53 -YRSVYQKRLMDEAKILKSLHHPNIVG---YRAFTEANDGSLCLAMEYGGEKSLNDLIEE 108 Query: 126 LWMHDQDPY-SDLVATTLRKVGRQIGLLHWND-YCHGDLTSSNIVLVRD 172 + QDP+ + ++ + R + LH HGD+ SSN+V+ D Sbjct: 109 RYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGD 157 >3LIJ-A nrPDB Length = 494 Score = 31.6 bits (70), Expect = 0.36, Method: Compositional matrix adjust. Identities = 35/161 (21%), Positives = 67/161 (41%), Gaps = 21/161 (13%) Query: 69 TKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGEDLPGGHGFSNLK 123 T T + S+LL ++ ++ L P ++ D N ++ +E GG F + Sbjct: 73 TSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECY----KGGELFDEII 128 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + + ++ D A +++V + LH ++ H DL N++L ++DF Sbjct: 129 HRMKFNEVDA-----AVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDF 183 Query: 184 GLGSV----SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 GL +V + E G Y+ + K+ EK + W Sbjct: 184 GLSAVFENQKKMKERLGTAYYIAPEVL---RKKYDEKCDVW 221 >3DFA-A nrPDB Length = 286 Score = 31.6 bits (70), Expect = 0.38, Method: Compositional matrix adjust. Identities = 25/118 (21%), Positives = 49/118 (41%), Gaps = 9/118 (7%) Query: 109 LGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIV 168 +GE GG F + + D A +++V I +H ++ H DL NI+ Sbjct: 99 VGELYTGGELFDEIIKRKRFSEHD-----AARIIKQVFSGITYMHKHNIVHRDLKPENIL 153 Query: 169 LVRDGARWTPHLIDFGLGSV----SNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 L +IDFGL + + + + G Y+ + T+ + + ++A ++ Sbjct: 154 LESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTYDEKCDVWSAGVI 211 >4XHL-A nrPDB Length = 394 Score = 31.2 bits (69), Expect = 0.42, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 56/134 (41%), Gaps = 30/134 (22%) Query: 58 RYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLI---ACDPYNGFIWLEFLG---E 111 R RHPQ+D ESR+ YL G+ +P + YN + ++ LG E Sbjct: 43 RSRHPQLDY---------ESRVYR--YLSGGVGIPFIRWFGREGEYNAMV-IDLLGPSLE 90 Query: 112 DLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR 171 DL F + H + + ++ L+ R I +H + H D+ N ++ Sbjct: 91 DL-----------FNYCHRRFSFKTVIMLALQMFCR-IQYIHGRSFIHRDIKPDNFLMGV 138 Query: 172 DGARWTPHLIDFGL 185 T H+IDFGL Sbjct: 139 GRRGSTVHVIDFGL 152 >5UIU-A nrPDB Length = 323 Score = 30.8 bits (68), Expect = 0.67, Method: Compositional matrix adjust. Identities = 18/41 (43%), Positives = 24/41 (58%), Gaps = 3/41 (7%) Query: 149 IGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS 189 I LH N + H D+ S+NI+L D A +T + DFGL S Sbjct: 162 INFLHENHHIHRDIKSANILL--DEA-FTAKISDFGLARAS 199 >3NCG-A nrPDB Length = 486 Score = 30.4 bits (67), Expect = 0.70, Method: Compositional matrix adjust. Identities = 36/175 (20%), Positives = 74/175 (42%), Gaps = 20/175 (11%) Query: 57 KRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGE 111 + Y I++A K++ + S +L ++ L+ L P ++ D + +I +GE Sbjct: 48 QEYAVKVINKASAKNK--DTSTILREVELLKKLDHPNIMKLFEILEDSSSFYI----VGE 101 Query: 112 DLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR 171 GG F + + D A +++V I +H ++ H DL NI+L Sbjct: 102 LYTGGELFDEIIKRKRFSEHD-----AARIIKQVFSGITYMHKHNIVHRDLKPENILLES 156 Query: 172 DGARWTPHLIDFGLGSV----SNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 +IDFGL + + + + G Y+ + T+ + + ++A ++ Sbjct: 157 KEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGTYDEKCDVWSAGVI 211 >3FXW-A nrPDB Length = 336 Score = 30.4 bits (67), Expect = 0.76, Method: Compositional matrix adjust. Identities = 32/152 (21%), Positives = 57/152 (37%), Gaps = 14/152 (9%) Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 ++G L + E + GG FS ++ DQ A +R +G I LH ++ H Sbjct: 95 HHGKRCLLIIMECMEGGELFSRIQE---RGDQAFTEREAAEIMRDIGTAIQFLHSHNIAH 151 Query: 160 GDLTSSNIVLVRDGARWTPHLIDFGLG--SVSNLVEDKGVDLYVLERAILSTHSKHAEKY 217 D+ N++ L DFG + N ++ Y + +L K+ + Sbjct: 152 RDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGP-EKYDKSC 210 Query: 218 NAW--------IMEGFEEVYREQGAKGAKKLK 241 + W ++ GF Y G + +K Sbjct: 211 DMWSLGVIMYILLCGFPPFYSNTGQAISPGMK 242 >1KOA-A nrPDB Length = 491 Score = 30.4 bits (67), Expect = 0.79, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 D +R+V + + +H N+Y H DL NI+ + LIDFGL Sbjct: 149 DEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNEL-KLIDFGL 197 >3UTO-A nrPDB Length = 573 Score = 30.0 bits (66), Expect = 0.92, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 1/50 (2%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 D +R+V + + +H N+Y H DL NI+ + LIDFGL Sbjct: 255 DEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNEL-KLIDFGL 303 >5HI2-A nrPDB Length = 283 Score = 30.0 bits (66), Expect = 0.99, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN 190 R+ R + LH H DL S+NI L D T + DFGL +V + Sbjct: 118 RQTARGMDYLHAKSIIHRDLKSNNIFLHEDN---TVKIGDFGLATVKS 162 >3COM-A nrPDB Length = 314 Score = 30.0 bits (66), Expect = 1.0, Method: Compositional matrix adjust. Identities = 17/69 (24%), Positives = 34/69 (49%), Gaps = 3/69 (4%) Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 G ++ + + + ++ D +AT L+ + + LH+ H D+ + NI+L +G Sbjct: 107 GAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGH--- 163 Query: 178 PHLIDFGLG 186 L DFG+ Sbjct: 164 AKLADFGVA 172 >2KHZ-A nrPDB Length = 165 Score = 30.0 bits (66), Expect = 1.1, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 11/113 (9%) Query: 106 LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIG--------LLHWNDY 157 LE LGE+ GG F + ++ W+ D V VG ++G +L Sbjct: 53 LEPLGEEAAGGDQFIHEQDLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRP 112 Query: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTH 210 G + S+ I DG+R+ + D+ G V ++ D+ + Y+ ++ S+H Sbjct: 113 QSGRVLSAMIRGAADGSRF--QVWDYAEGEVETML-DRYFEAYLPQKTASSSH 162 >4L00-A nrPDB Length = 304 Score = 29.6 bits (65), Expect = 1.2, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 16/84 (19%) Query: 126 LWMHDQDPYSDLVATTLR-KVGRQIG----LLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 L+MH + SD++ T + KV +Q+ L D HG++ + N++L R+G Sbjct: 121 LFMHRK---SDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREG------- 170 Query: 181 IDFGLGSVSNLVEDKGVDLYVLER 204 ID G L D G+ + VL R Sbjct: 171 IDSECGPFIKL-SDPGIPITVLSR 193 >4WNO-A nrPDB Length = 287 Score = 29.6 bits (65), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 10/85 (11%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR-DGARWTPHLI-----DFGLGSV- 188 D + L+++ + LLH H DL NI+L G R P+ I DFG Sbjct: 117 DTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL 176 Query: 189 -SNLVEDK--GVDLYVLERAILSTH 210 SN++ G +Y+ I+S H Sbjct: 177 QSNMMAATLCGSPMYMAPEVIMSQH 201 >4AU8-A nrPDB Length = 296 Score = 29.6 bits (65), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/66 (27%), Positives = 33/66 (50%), Gaps = 3/66 (4%) Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 +LK + + D ++V + L ++ + +G H + H DL N+++ R+G L Sbjct: 90 DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGEL---KL 146 Query: 181 IDFGLG 186 DFGL Sbjct: 147 ADFGLA 152 >4QMW-A nrPDB Length = 310 Score = 29.6 bits (65), Expect = 1.4, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 3/49 (6%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +AT LR++ + + LH H D+ ++N++L G L DFG+ Sbjct: 128 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEV---KLADFGVA 173 >4KXN-A nrPDB Length = 152 Score = 29.6 bits (65), Expect = 1.5, Method: Compositional matrix adjust. Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 11/106 (10%) Query: 106 LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIG--------LLHWNDY 157 LE LGE+ GG F + +N W+ D V VG ++G +L Sbjct: 44 LEPLGEEAAGGDQFIHEQNLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRP 103 Query: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLE 203 G + S+ I DG+R+ + D+ G V ++ D+ + Y++E Sbjct: 104 QSGRVLSAMIRGAADGSRF--QVWDYAEGEVETML-DRYFEAYLVE 146 >4KIK-B nrPDB Length = 677 Score = 29.3 bits (64), Expect = 1.6, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 21/47 (44%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + T L + + LH N H DL NIVL + R +ID G Sbjct: 128 ILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLG 174 >4APC-A nrPDB Length = 350 Score = 29.3 bits (64), Expect = 1.7, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 3/39 (7%) Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN 190 +H H D+ S NI L +DG T L DFG+ V N Sbjct: 141 VHDRKILHRDIKSQNIFLTKDG---TVQLGDFGIARVLN 176 >4G3E-A nrPDB Length = 352 Score = 29.3 bits (64), Expect = 1.8, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%) Query: 82 KLYLIPGLCVPQLIACDPYNGFI----WLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 +L GL P+++ P G + W+ E L GG +K + + D Sbjct: 116 ELVACAGLSSPRIV---PLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPE-----DR 167 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 L + + LH HGD+ + N++L DG+R L DFG Sbjct: 168 ALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAA--LCDFG 212 >2XIK-A nrPDB Length = 294 Score = 29.3 bits (64), Expect = 1.9, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 26/49 (53%), Gaps = 3/49 (6%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +AT LR++ + + LH H D+ ++N++L G L DFG+ Sbjct: 118 IATILREILKGLDYLHSERKIHRDIKAANVLLSEQG---DVKLADFGVA 163 >6AO5-A nrPDB Length = 362 Score = 28.9 bits (63), Expect = 2.6, Method: Compositional matrix adjust. Identities = 16/69 (23%), Positives = 34/69 (49%), Gaps = 3/69 (4%) Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 G ++ + + + ++ D +AT L+ + + LH+ H ++ + NI+L +G Sbjct: 88 GAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGH--- 144 Query: 178 PHLIDFGLG 186 L DFG+ Sbjct: 145 AKLADFGVA 153 >3F3Z-A nrPDB Length = 277 Score = 28.9 bits (63), Expect = 2.6, Method: Compositional matrix adjust. Identities = 20/89 (22%), Positives = 37/89 (41%), Gaps = 4/89 (4%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---VSNLVED 194 A ++ V + H + H DL N + + D LIDFGL + ++ Sbjct: 108 AARIMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRT 167 Query: 195 K-GVDLYVLERAILSTHSKHAEKYNAWIM 222 K G YV + + + ++++A +M Sbjct: 168 KVGTPYYVSPQVLEGLYGPECDEWSAGVM 196 >6CKI-A nrPDB Length = 316 Score = 28.5 bits (62), Expect = 2.7, Method: Compositional matrix adjust. Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 5/101 (4%) Query: 128 MHDQDPYSDLVATTL-RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +H + +++L A+ + + V + LH H DL NI+ + DFGLG Sbjct: 102 IHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLG 161 Query: 187 SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEE 227 S L D + L T AE ++E F E Sbjct: 162 SGIKL----NGDCSPISTPELLTPCGSAEYMAPEVVEAFSE 198 >4LG4-A nrPDB Length = 299 Score = 28.5 bits (62), Expect = 2.8, Method: Compositional matrix adjust. Identities = 16/69 (23%), Positives = 34/69 (49%), Gaps = 3/69 (4%) Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 G ++ + + + ++ D +AT L+ + + LH+ H ++ + NI+L +G Sbjct: 89 GAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHA-- 146 Query: 178 PHLIDFGLG 186 L DFG+ Sbjct: 147 -KLADFGVA 154 >4NST-A nrPDB Length = 351 Score = 28.5 bits (62), Expect = 3.2, Method: Compositional matrix adjust. Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 3/60 (5%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK 195 D + + ++++ + H ++ H D+ SNI+L G L DFGL + N E + Sbjct: 122 DHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG---QIKLADFGLARLYNSEESR 178 >4MLQ-A nrPDB Length = 312 Score = 28.5 bits (62), Expect = 3.4, Method: Compositional matrix adjust. Identities = 12/33 (36%), Positives = 17/33 (51%) Query: 7 DKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYL 39 D V+ YL P++ + + QGA AI H L Sbjct: 182 DTVTQYLEPEISVPAVGQGALAIECRENDHELL 214 >5Y86-A nrPDB Length = 588 Score = 28.1 bits (61), Expect = 3.6, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%) Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 LV + + + + LH N H DL NI+L G R + +IDFG Sbjct: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHG-RSSTKVIDFG 357 >6HIV-BB nrPDB Length = 541 Score = 28.1 bits (61), Expect = 4.0, Method: Compositional matrix adjust. Identities = 22/62 (35%), Positives = 33/62 (53%), Gaps = 7/62 (11%) Query: 172 DGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWI---MEGFEEV 228 DGAR T HL F V+ GV++ ++ A +TH + E+Y A+I + FE V Sbjct: 206 DGAR-TDHLPRFAHNP---YVDPDGVEVTEVDIAPFNTHEQIKERYGAFIDPDLRPFEGV 261 Query: 229 YR 230 +R Sbjct: 262 FR 263 >5I2K-B nrPDB Length = 293 Score = 28.1 bits (61), Expect = 4.2, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 27/55 (49%), Gaps = 4/55 (7%) Query: 168 VLVRDGARWT----PHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYN 218 +LV+ G R T P L + + V+ VD+Y + LST +H EK+N Sbjct: 149 ILVKKGTRITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHN 203 >2RSV-A nrPDB Length = 403 Score = 27.7 bits (60), Expect = 4.7, Method: Compositional matrix adjust. Identities = 12/35 (34%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +H ++Y HGD+ +SN++L +L+D+GL Sbjct: 175 IHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLA 208 >5HIE-A nrPDB Length = 302 Score = 27.7 bits (60), Expect = 4.8, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 3/48 (6%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN 190 R+ + + LH H DL S+NI L D T + DFGL +V + Sbjct: 134 RQTAQGMDYLHAKSIIHRDLKSNNIFLHED---LTVKIGDFGLATVKS 178 >2LAV-A nrPDB Length = 361 Score = 27.7 bits (60), Expect = 4.9, Method: Compositional matrix adjust. Identities = 12/35 (34%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +H ++Y HGD+ +SN++L +L+D+GL Sbjct: 168 IHEHEYVHGDIKASNLLLNYKNPDQV-YLVDYGLA 201 >3DH7-A nrPDB Length = 332 Score = 27.7 bits (60), Expect = 5.0, Method: Compositional matrix adjust. Identities = 17/47 (36%), Positives = 23/47 (48%) Query: 204 RAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEV 250 R +L + AE+ AWI + EE+ A GA+ KE R E V Sbjct: 286 RPLLRPALEGAERVAAWIGDYLEELRTALFAIGARNPKEARGRVERV 332 >3QA8-A nrPDB Length = 676 Score = 27.7 bits (60), Expect = 5.2, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 20/47 (42%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + T L + + LH N H DL NIVL R +ID G Sbjct: 123 IRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLG 169 >4JXF-A nrPDB Length = 266 Score = 27.7 bits (60), Expect = 5.5, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 33/72 (45%), Gaps = 6/72 (8%) Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLERAI---LS 208 LH + H DLT SN++L R+ + DFGL + + +K L I ++ Sbjct: 124 LHSHGILHRDLTLSNLLLTRN---MNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIA 180 Query: 209 THSKHAEKYNAW 220 T S H + + W Sbjct: 181 TRSAHGLESDVW 192 >2F57-A nrPDB Length = 317 Score = 27.7 bits (60), Expect = 5.7, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 22/48 (45%), Gaps = 3/48 (6%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 +AT V R + LH H D+ S +I+L DG L DFG Sbjct: 143 IATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDG---RIKLSDFGF 187 >5UU1-A nrPDB Length = 324 Score = 27.7 bits (60), Expect = 5.8, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 17/96 (17%) Query: 106 LEFLGEDLPGGHGFSNLKN----FLWMH----DQDPYSDLVATTLRKVGRQIGL------ 151 L++LG L G G + K F+ M D S T + Q+G+ Sbjct: 84 LDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVL 143 Query: 152 --LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 +H N+Y HGD+ ++N++L +L D+GL Sbjct: 144 EYIHENEYVHGDIKAANLLLGYKNPDQV-YLADYGL 178 >5XGF-A nrPDB Length = 300 Score = 27.3 bits (59), Expect = 6.2, Method: Compositional matrix adjust. Identities = 16/55 (29%), Positives = 26/55 (47%) Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 TTLR+V +++ W HG T N + G L+ + + +N+VED Sbjct: 67 TTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGLHILDTLMTLDVDNATNIVED 121 >3NRE-A nrPDB Length = 291 Score = 27.3 bits (59), Expect = 7.2, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 19/32 (59%), Gaps = 3/32 (9%) Query: 12 YLTPD---VDIAPISQGAEAIVFTTTTHPYLP 40 +LT D V ++ +QGAE + F T HPY P Sbjct: 122 HLTADTLTVTLSVTNQGAETLPFGTGWHPYFP 153 >1XB4-A nrPDB Length = 202 Score = 27.3 bits (59), Expect = 7.2, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 29/54 (53%), Gaps = 1/54 (1%) Query: 1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPY-LPRAKDSHQKYIIKY 53 ++Q FID++ S +T + PI Q TTTT + L ++ DS I+++ Sbjct: 85 VSQVFIDEIWSQMTKEGKCLPIDQSGRRSSNTTTTRYFILWKSLDSWASLILQW 138 >4MVF-A nrPDB Length = 506 Score = 26.9 bits (58), Expect = 8.0, Method: Compositional matrix adjust. Identities = 14/49 (28%), Positives = 22/49 (44%) Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 AT ++++ I LH + H DL N + + +IDFGL Sbjct: 156 AATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLS 204 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4WWA-A nrPDB 441 e-124 3ENH-A nrPDB 218 2e-57 5JN2-A nrPDB 173 1e-43 3MA6-A nrPDB 170 5e-43 Sequences not found previously or not previously below threshold: 4YZB-A nrPDB 146 1e-35 4RGJ-A nrPDB 136 1e-32 3DFA-A nrPDB 130 8e-31 3NCG-A nrPDB 129 1e-30 3DXN-A nrPDB 121 3e-28 3HZT-A nrPDB 120 6e-28 3LIJ-A nrPDB 119 1e-27 3Q5I-A nrPDB 109 2e-24 3F3Z-A nrPDB 100 7e-22 4MVF-A nrPDB 99 1e-21 2W4O-A nrPDB 88 5e-18 2JAM-A nrPDB 83 1e-16 3IS5-A nrPDB 77 5e-15 3KN6-A nrPDB 76 2e-14 2JC6-A nrPDB 74 6e-14 3FXW-A nrPDB 74 8e-14 2BDW-A nrPDB 73 1e-13 3KK8-A nrPDB 72 2e-13 5FG8-A nrPDB 72 2e-13 2V7O-A nrPDB 72 2e-13 4YNZ-A nrPDB 71 4e-13 3MN3-A nrPDB 71 4e-13 3KA0-A nrPDB 71 4e-13 2VN9-A nrPDB 71 6e-13 3HKO-A nrPDB 70 1e-12 4FG9-A nrPDB 70 1e-12 1NY3-A nrPDB 69 2e-12 6DTL-A nrPDB 69 2e-12 2OZA-A nrPDB 69 2e-12 3H4J-B nrPDB 68 3e-12 4NIF-A nrPDB 68 4e-12 2Y7J-A nrPDB 68 4e-12 3I6U-A nrPDB 67 1e-11 2YCR-A nrPDB 66 1e-11 1PHK-A nrPDB 66 1e-11 4JG6-A nrPDB 65 3e-11 4D28-A nrPDB 65 3e-11 2YZA-A nrPDB 65 3e-11 3BHH-A nrPDB 65 3e-11 5IG1-A nrPDB 65 4e-11 4CQG-A nrPDB 65 4e-11 5DBX-A nrPDB 64 4e-11 3GUB-A nrPDB 64 4e-11 4RED-A nrPDB 64 6e-11 5ES1-A nrPDB 64 7e-11 4REW-A nrPDB 64 8e-11 4CFF-A nrPDB 64 9e-11 2HW6-A nrPDB 63 1e-10 2BRG-A nrPDB 63 1e-10 6C9D-A nrPDB 63 1e-10 4CZT-A nrPDB 63 1e-10 2VZ6-A nrPDB 63 1e-10 5KZ7-A nrPDB 63 1e-10 5EZV-A nrPDB 62 2e-10 5U6Y-A nrPDB 62 2e-10 4CFH-A nrPDB 62 2e-10 2QNJ-A nrPDB 62 2e-10 2HAK-A nrPDB 62 2e-10 2YAB-A nrPDB 62 3e-10 2J90-A nrPDB 62 3e-10 3SOA-A nrPDB 62 3e-10 1V0B-A nrPDB 61 4e-10 4D2V-A nrPDB 61 4e-10 3DAK-A nrPDB 61 4e-10 4B8L-A nrPDB 60 1e-09 3M42-A nrPDB 59 2e-09 4EWQ-A nrPDB 59 2e-09 3LM0-A nrPDB 59 2e-09 5WAX-A nrPDB 59 2e-09 3D2K-A nrPDB 59 3e-09 2A27-A nrPDB 59 3e-09 6CKI-A nrPDB 59 3e-09 5YKS-A nrPDB 59 3e-09 4WNO-A nrPDB 58 3e-09 1ZWS-A nrPDB 58 3e-09 2W96-B nrPDB 58 3e-09 4QTB-A nrPDB 58 4e-09 3OHT-A nrPDB 58 4e-09 3UC3-A nrPDB 58 4e-09 5AWM-A nrPDB 58 4e-09 3E7O-A nrPDB 58 4e-09 4KRC-A nrPDB 58 5e-09 1JNK-A nrPDB 57 5e-09 6GU6-A nrPDB 57 5e-09 5JZN-A nrPDB 57 6e-09 5XZW-A nrPDB 57 6e-09 4JXF-A nrPDB 57 6e-09 3NIZ-A nrPDB 57 6e-09 3FI2-A nrPDB 57 6e-09 2BPM-A nrPDB 57 8e-09 6QAU-A nrPDB 57 8e-09 3MIA-A nrPDB 57 1e-08 5NGU-A nrPDB 56 1e-08 1KOB-A nrPDB 56 1e-08 3DLS-A nrPDB 56 1e-08 3UTO-A nrPDB 56 2e-08 2F9G-A nrPDB 56 2e-08 5TQX-A nrPDB 56 2e-08 3UDB-A nrPDB 56 2e-08 2XS0-A nrPDB 56 2e-08 4AU8-A nrPDB 56 2e-08 5DYK-A nrPDB 56 2e-08 1UA2-A nrPDB 55 3e-08 1KOA-A nrPDB 55 3e-08 3ZUT-A nrPDB 55 3e-08 6CMJ-A nrPDB 55 3e-08 4UZD-A nrPDB 55 3e-08 5EFQ-A nrPDB 55 3e-08 5YV8-A nrPDB 55 3e-08 5G6V-A nrPDB 55 3e-08 4AF3-A nrPDB 55 3e-08 4NST-A nrPDB 54 5e-08 3GC9-A nrPDB 54 5e-08 3HDN-A nrPDB 54 6e-08 2UV2-A nrPDB 54 6e-08 1FOT-A nrPDB 54 6e-08 4APC-A nrPDB 54 7e-08 4BBM-A nrPDB 54 8e-08 4AGU-A nrPDB 54 8e-08 4PDS-A nrPDB 54 9e-08 4IC8-A nrPDB 53 1e-07 1G3N-A nrPDB 53 1e-07 4ZSG-A nrPDB 52 2e-07 3QA8-A nrPDB 52 2e-07 4KIK-B nrPDB 52 2e-07 5FET-A nrPDB 52 2e-07 6HXF-B nrPDB 52 2e-07 5WNO-A nrPDB 52 3e-07 6FDY-U nrPDB 52 3e-07 2JDO-A nrPDB 52 3e-07 4RLP-A nrPDB 52 3e-07 2Z7Q-A nrPDB 52 3e-07 1CM8-A nrPDB 51 4e-07 5D9K-A nrPDB 51 5e-07 4L42-A nrPDB 51 5e-07 4CRL-A nrPDB 51 5e-07 6FD3-A nrPDB 51 6e-07 3Q53-A nrPDB 51 6e-07 5KCV-A nrPDB 51 6e-07 2X4F-A nrPDB 51 6e-07 3MV5-A nrPDB 51 6e-07 5X3F-B nrPDB 51 8e-07 2F57-A nrPDB 50 8e-07 4O2Z-A nrPDB 50 9e-07 1U5R-A nrPDB 50 9e-07 3DB8-A nrPDB 50 1e-06 5O2B-A nrPDB 50 1e-06 2OU7-A nrPDB 50 1e-06 4J52-A nrPDB 50 1e-06 4QMW-A nrPDB 50 1e-06 2GCD-A nrPDB 50 1e-06 5Z33-A nrPDB 50 1e-06 3KUL-B nrPDB 50 1e-06 3ZDU-A nrPDB 49 1e-06 6BFN-A nrPDB 49 2e-06 4WB7-A nrPDB 49 2e-06 5LOH-A nrPDB 49 2e-06 4KS7-A nrPDB 49 2e-06 5O2C-A nrPDB 49 2e-06 3GC0-A nrPDB 49 2e-06 3TAC-A nrPDB 49 3e-06 5D7A-A nrPDB 49 3e-06 3PPZ-A nrPDB 48 4e-06 2XIK-A nrPDB 48 4e-06 6CCF-A nrPDB 48 4e-06 1S9I-A nrPDB 48 4e-06 4E7W-A nrPDB 48 4e-06 1U59-A nrPDB 48 4e-06 4AN9-A nrPDB 48 5e-06 1ZXE-A nrPDB 47 6e-06 2I6L-A nrPDB 47 7e-06 5KKR-C nrPDB 47 8e-06 3N9X-A nrPDB 47 9e-06 5AIR-A nrPDB 47 9e-06 4TPT-A nrPDB 47 9e-06 4BGQ-A nrPDB 47 9e-06 3EQC-A nrPDB 47 1e-05 4I6B-A nrPDB 47 1e-05 6E2O-A nrPDB 46 1e-05 5HI2-A nrPDB 46 1e-05 2XNP-A nrPDB 46 2e-05 4GS6-A nrPDB 46 2e-05 4C0T-A nrPDB 46 2e-05 5UUU-A nrPDB 46 2e-05 4MYG-A nrPDB 46 2e-05 4B6L-A nrPDB 46 2e-05 4Y83-A nrPDB 46 2e-05 5O0Y-A nrPDB 46 2e-05 1VZO-A nrPDB 46 2e-05 3NIE-A nrPDB 46 2e-05 3PVW-A nrPDB 45 3e-05 2H34-A nrPDB 45 3e-05 3EB0-A nrPDB 45 3e-05 6BDL-A nrPDB 45 3e-05 4PWN-A nrPDB 45 3e-05 4G3E-A nrPDB 45 3e-05 4FR4-A nrPDB 45 3e-05 5F9E-A nrPDB 45 4e-05 4LQP-A nrPDB 45 4e-05 4QNY-A nrPDB 45 4e-05 5M07-A nrPDB 45 4e-05 5HIE-A nrPDB 45 4e-05 6CQF-A nrPDB 44 5e-05 5HVK-A nrPDB 44 5e-05 5N23-A nrPDB 44 5e-05 4HZS-A nrPDB 44 5e-05 2WQN-A nrPDB 44 5e-05 1U54-B nrPDB 44 5e-05 5FQD-C nrPDB 44 5e-05 4U41-A nrPDB 44 6e-05 4AW2-A nrPDB 44 6e-05 4TNB-A nrPDB 44 7e-05 4JDH-A nrPDB 44 7e-05 2Q0N-A nrPDB 44 8e-05 4YFF-A nrPDB 44 8e-05 4NEU-A nrPDB 44 8e-05 3E3P-A nrPDB 44 8e-05 3ORZ-A nrPDB 44 9e-05 5Y86-A nrPDB 44 9e-05 4TN6-A nrPDB 44 1e-04 5TOS-A nrPDB 44 1e-04 4CSV-A nrPDB 43 1e-04 4FIE-A nrPDB 43 1e-04 3OMV-A nrPDB 43 1e-04 4XBR-A nrPDB 43 1e-04 4CI6-B nrPDB 43 1e-04 4EQM-A nrPDB 43 1e-04 4LG4-A nrPDB 43 1e-04 3COM-A nrPDB 43 1e-04 6BXI-A nrPDB 43 1e-04 2PL0-A nrPDB 43 2e-04 3SV0-A nrPDB 42 2e-04 3PLS-A nrPDB 42 2e-04 4HVI-A nrPDB 42 2e-04 5L2Q-C nrPDB 42 2e-04 6DBM-A nrPDB 42 2e-04 3C51-A nrPDB 42 2e-04 5J5T-A nrPDB 42 2e-04 5J0A-A nrPDB 42 3e-04 4FZF-B nrPDB 42 3e-04 5H2U-A nrPDB 42 3e-04 6AO5-A nrPDB 42 3e-04 4RA4-A nrPDB 42 3e-04 5ZTN-A nrPDB 42 3e-04 4P5Q-A nrPDB 42 3e-04 4M7I-A nrPDB 42 3e-04 2PMN-X nrPDB 42 3e-04 6E9W-A nrPDB 42 3e-04 1BYG-A nrPDB 42 4e-04 4XHH-A nrPDB 42 4e-04 4IDT-A nrPDB 42 4e-04 1K9A-A nrPDB 41 4e-04 5L6P-A nrPDB 41 4e-04 5SYS-A nrPDB 41 5e-04 4OLI-A nrPDB 41 5e-04 5UIU-A nrPDB 41 5e-04 3TKU-A nrPDB 41 6e-04 6ED6-A nrPDB 41 6e-04 4XHL-A nrPDB 41 6e-04 2H8H-A nrPDB 41 7e-04 3RP9-A nrPDB 41 8e-04 5TUR-A nrPDB 41 8e-04 3BGP-A nrPDB 41 8e-04 2HK5-A nrPDB 41 8e-04 3SXS-A nrPDB 41 8e-04 3TXO-A nrPDB 40 0.001 1AD5-A nrPDB 40 0.001 5VO2-A nrPDB 40 0.001 5VC6-A nrPDB 40 0.001 4RC3-A nrPDB 40 0.001 5CLR-A nrPDB 40 0.001 3QD2-B nrPDB 40 0.001 3IO7-A nrPDB 40 0.001 2Y6O-A nrPDB 40 0.001 2CMW-A nrPDB 40 0.001 2VD5-A nrPDB 40 0.001 5AR8-A nrPDB 40 0.001 2W1I-A nrPDB 40 0.001 4YHJ-A nrPDB 40 0.001 2VWV-A nrPDB 40 0.001 6F3F-A nrPDB 39 0.002 6B2Q-A nrPDB 39 0.002 4X3F-A nrPDB 39 0.002 4OW8-A nrPDB 39 0.002 4X7Q-B nrPDB 39 0.002 5UNP-A nrPDB 39 0.002 5UU1-A nrPDB 39 0.002 3UIU-A nrPDB 39 0.002 2RIO-A nrPDB 39 0.002 4UY9-A nrPDB 39 0.002 6J5U-C nrPDB 39 0.002 6FYV-A nrPDB 39 0.002 1JPA-A nrPDB 39 0.002 2DQ7-X nrPDB 39 0.002 5B2L-A nrPDB 39 0.002 2LAV-A nrPDB 39 0.002 3DTC-A nrPDB 39 0.002 4UYA-A nrPDB 39 0.002 5DMZ-A nrPDB 39 0.002 2Y4I-B nrPDB 39 0.002 2RSV-A nrPDB 39 0.002 6HMD-A nrPDB 39 0.002 4MD7-E nrPDB 39 0.003 2XYN-A nrPDB 39 0.003 1FVR-A nrPDB 39 0.003 6GVJ-A nrPDB 39 0.003 3NYO-A nrPDB 39 0.003 3OZ6-A nrPDB 39 0.003 4NT4-A nrPDB 38 0.003 5X18-A nrPDB 38 0.003 5AMN-A nrPDB 38 0.004 4FL3-A nrPDB 38 0.004 4F9B-A nrPDB 38 0.005 4E20-A nrPDB 38 0.005 5X8I-B nrPDB 38 0.005 5VDK-A nrPDB 38 0.005 6EII-A nrPDB 37 0.006 4PL5-B nrPDB 37 0.006 6HV0-A nrPDB 37 0.006 3ORP-A nrPDB 37 0.006 5C26-A nrPDB 37 0.006 2PVN-A nrPDB 37 0.006 5AP3-A nrPDB 37 0.007 3PP0-A nrPDB 37 0.007 3PG1-A nrPDB 37 0.007 3HMP-A nrPDB 37 0.008 5XVU-A nrPDB 37 0.008 6CTH-A nrPDB 37 0.008 4XEY-B nrPDB 37 0.009 6NPU-A nrPDB 37 0.009 4Y12-A nrPDB 37 0.009 2PZI-A nrPDB 37 0.009 1LUF-A nrPDB 37 0.010 2A1A-B nrPDB 37 0.010 4M66-A nrPDB 37 0.011 3RAW-A nrPDB 37 0.012 5HLW-A nrPDB 36 0.013 2QKW-B nrPDB 36 0.014 5CEK-A nrPDB 36 0.014 6DC0-A nrPDB 36 0.014 6DBN-A nrPDB 36 0.014 2C47-A nrPDB 36 0.015 4F0G-A nrPDB 36 0.015 4LFI-A nrPDB 36 0.016 4JLC-A nrPDB 36 0.018 2R2P-A nrPDB 36 0.018 3A4O-X nrPDB 36 0.019 2CHL-A nrPDB 36 0.021 3A8W-A nrPDB 36 0.022 2ZMD-A nrPDB 36 0.023 2X7G-A nrPDB 36 0.023 5FM2-A nrPDB 36 0.025 5OAT-A nrPDB 36 0.026 1PY5-A nrPDB 35 0.028 3ALO-A nrPDB 35 0.028 3C1X-A nrPDB 35 0.031 4PDO-A nrPDB 35 0.036 6EQI-C nrPDB 35 0.040 5E8V-A nrPDB 35 0.040 4C59-A nrPDB 35 0.041 1TKI-A nrPDB 35 0.043 3AOX-A nrPDB 35 0.044 5X5O-A nrPDB 35 0.045 3DKO-A nrPDB 34 0.049 1CSN-A nrPDB 34 0.050 5MJB-A nrPDB 34 0.055 4BTK-A nrPDB 34 0.071 3UIM-A nrPDB 34 0.071 3CJF-A nrPDB 34 0.078 6FER-A nrPDB 34 0.083 4NFN-A nrPDB 34 0.083 4JRN-A nrPDB 34 0.084 3BBT-B nrPDB 34 0.090 2WTK-B nrPDB 33 0.11 3LZB-A nrPDB 33 0.11 3Q4U-A nrPDB 33 0.12 3VHK-A nrPDB 33 0.12 4H1J-A nrPDB 33 0.13 4EBW-A nrPDB 33 0.14 4O1O-A nrPDB 33 0.14 4WUA-A nrPDB 33 0.14 5LPV-A nrPDB 33 0.15 5LPZ-A nrPDB 33 0.15 4IX6-A nrPDB 33 0.17 4XD0-A nrPDB 32 0.18 4LRM-A nrPDB 32 0.18 5GNK-A nrPDB 32 0.19 3I81-A nrPDB 32 0.19 3QGY-A nrPDB 32 0.21 6FEX-A nrPDB 32 0.21 2BUJ-A nrPDB 32 0.22 2J0K-A nrPDB 32 0.26 3VN9-A nrPDB 32 0.27 3FME-A nrPDB 32 0.28 5VD3-A nrPDB 32 0.29 5X1R-A nrPDB 32 0.30 6BSD-A nrPDB 32 0.32 4L00-A nrPDB 32 0.33 4AT3-A nrPDB 32 0.35 5U6B-A nrPDB 32 0.36 5XD6-A nrPDB 32 0.39 2WTK-C nrPDB 31 0.44 2WO6-A nrPDB 31 0.45 2JII-A nrPDB 31 0.54 3HNG-A nrPDB 31 0.56 3V5Q-A nrPDB 31 0.66 5IKW-A nrPDB 30 0.84 6EF6-A nrPDB 30 0.85 4IAN-A nrPDB 30 0.89 1TQM-A nrPDB 30 0.97 5TE0-A nrPDB 30 1.0 6G4J-A nrPDB 30 1.2 3J7A-H nrPDB 30 1.3 4XLV-A nrPDB 30 1.4 3LLT-A nrPDB 29 2.2 4OAU-C nrPDB 29 2.2 3G0E-A nrPDB 29 2.6 6GQK-A nrPDB 29 3.3 4MLQ-A nrPDB 28 4.0 3Q9T-A nrPDB 28 4.8 2ZIG-A nrPDB 28 4.9 3ZZW-A nrPDB 28 5.0 4LIV-A nrPDB 27 5.8 2JD5-A nrPDB 27 6.9 1ZP9-A nrPDB 27 7.6 5USZ-A nrPDB 27 8.2 >4WWA-A nrPDB Length = 261 Score = 441 bits (1133), Expect = e-124, Method: Composition-based stats. Identities = 261/261 (100%), Positives = 261/261 (100%) Query: 1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR 60 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR Sbjct: 1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR 60 Query: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS 120 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS Sbjct: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS 120 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL Sbjct: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 Query: 181 IDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKL 240 IDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKL Sbjct: 181 IDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKL 240 Query: 241 KEVTKRFEEVRLRGRKRSMLG 261 KEVTKRFEEVRLRGRKRSMLG Sbjct: 241 KEVTKRFEEVRLRGRKRSMLG 261 >3ENH-A nrPDB Length = 540 Score = 218 bits (554), Expect = 2e-57, Method: Composition-based stats. Identities = 70/213 (32%), Positives = 104/213 (48%), Gaps = 42/213 (19%) Query: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKY--IIKYRPPKRYRHPQIDQALTKHRTLNESRL 79 I +GAEA + +DS+ + IIK R K YR ++D+ + K RT E+R Sbjct: 344 IGKGAEADI-----------KRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARY 392 Query: 80 LAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 LA L G+ P + D N I + ++ L D++ Sbjct: 393 LA-LVKDFGIPAPYIFDVDLDNKRIMMSYINGKLA--------------------KDVIE 431 Query: 140 TTLR---KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKG 196 L K+G +G LH ND H DLT+SN + +D ++IDFGLG +SNL EDK Sbjct: 432 DNLDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD-----LYIIDFGLGKISNLDEDKA 486 Query: 197 VDLYVLERAILSTHSKHAEKYNAWIMEGFEEVY 229 VDL V ++A+LSTH + ++ +EG++ VY Sbjct: 487 VDLIVFKKAVLSTHHEKFDEIWERFLEGYKSVY 519 >5JN2-A nrPDB Length = 525 Score = 173 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 16/163 (9%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFS 120 I + K +T ES LL ++ L+ L P ++ + G+ +L +GE GG F Sbjct: 100 ISKRQVKQKTDKES-LLREVQLLKQLDHPNIMKLYEFFEDKGYFYL--VGEVYTGGELFD 156 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + + + D A +R+V I +H N H DL N++L + Sbjct: 157 EIISRKRFSEVD-----AARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRI 211 Query: 181 IDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 IDFGL + S ++DK Y + +L H + EK + W Sbjct: 212 IDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVW 252 >3MA6-A nrPDB Length = 298 Score = 170 bits (431), Expect = 5e-43, Method: Composition-based stats. Identities = 43/163 (26%), Positives = 70/163 (42%), Gaps = 16/163 (9%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFS 120 I + K +T ES LL ++ L+ L P ++ + G+ +L +GE GG F Sbjct: 65 ISKRQVKQKTDKES-LLREVQLLKQLDHPNIMKLYEFFEDKGYFYL--VGEVYTGGELFD 121 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + + + D A +R+V I +H N H DL N++L + Sbjct: 122 EIISRKRFSEVD-----AARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRI 176 Query: 181 IDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 IDFGL + S ++DK Y + +L H + EK + W Sbjct: 177 IDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVW 217 >4YZB-A nrPDB Length = 491 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 39/163 (23%), Positives = 67/163 (41%), Gaps = 16/163 (9%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFS 120 I + K +T E L ++ L+ L P ++ + G+ +L + E GG F Sbjct: 63 ISKRQVKQKTDKELLL-KEVELLKKLDHPNIMKLYEFFEDKGYFYL--VTEVYTGGELFD 119 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + + + D A +R+V I +H N H DL N++L + Sbjct: 120 EIISRKRFSEVD-----AARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRI 174 Query: 181 IDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 IDFGL + + ++DK Y + +L H + EK + W Sbjct: 175 IDFGLSTHFESTKKMKDKIGTAYYIAPEVL--HGTYDEKCDVW 215 >4RGJ-A nrPDB Length = 520 Score = 136 bits (341), Expect = 1e-32, Method: Composition-based stats. Identities = 39/164 (23%), Positives = 70/164 (42%), Gaps = 17/164 (10%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFS 120 I + K +T ES LL ++ L+ L ++ + N + +L + + GG F Sbjct: 93 ISKKHVKRKTDKES-LLREVELLKMLDHINIMKLYEFFEDNNYYYL--VSDVYTGGELFD 149 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA-RWTPH 179 + + ++ D A ++++ I +H N+ H DL NI+L Sbjct: 150 EIISRKRFYEID-----AARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIK 204 Query: 180 LIDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +IDFGL + S ++DK Y + +L H + EK + W Sbjct: 205 IIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL--HGTYDEKCDIW 246 >3DFA-A nrPDB Length = 286 Score = 130 bits (326), Expect = 8e-31, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 63/160 (39%), Gaps = 15/160 (9%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLK 123 + + S +L ++ L+ L P ++ + ++ +GE GG F + Sbjct: 56 NKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYI--VGELYTGGELFDEII 113 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + D A +++V I +H ++ H DL NI+L +IDF Sbjct: 114 KRKRFSEHD-----AARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDF 168 Query: 184 GLGSV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 GL + + ++D+ Y + +L + EK + W Sbjct: 169 GLSTCFQQNTKMKDRIGTAYYIAPEVL--RGTYDEKCDVW 206 >3NCG-A nrPDB Length = 486 Score = 129 bits (323), Expect = 1e-30, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 63/160 (39%), Gaps = 15/160 (9%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLK 123 + + S +L ++ L+ L P ++ + ++ +GE GG F + Sbjct: 56 NKASAKNKDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYI--VGELYTGGELFDEII 113 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + D A +++V I +H ++ H DL NI+L +IDF Sbjct: 114 KRKRFSEHD-----AARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDF 168 Query: 184 GLGSV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 GL + + ++D+ Y + +L + EK + W Sbjct: 169 GLSTCFQQNTKMKDRIGTAYYIAPEVL--RGTYDEKCDVW 206 >3DXN-A nrPDB Length = 287 Score = 121 bits (304), Expect = 3e-28, Method: Composition-based stats. Identities = 42/208 (20%), Positives = 78/208 (37%), Gaps = 19/208 (9%) Query: 23 SQGAEAIVFTTTTHPYLPRAKDSHQKY----IIKYRPPKRYRHPQIDQALTKHRTLNESR 78 S G E + F + Y K Y + K + R +I + + T N Sbjct: 8 SSGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGA 67 Query: 79 LLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 LL ++ ++ L P ++ + +L + E GG F + + D Sbjct: 68 LLDEVAVLKQLDHPNIMKLYEFFEDKRNYYL--VMEVYRGGELFDEIILRQKFSEVD--- 122 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---VSNLV 192 A +++V LH ++ H DL N++L ++DFGL + V + Sbjct: 123 --AAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM 180 Query: 193 EDKGVDLYVLERAILSTHSKHAEKYNAW 220 +++ Y + +L K+ EK + W Sbjct: 181 KERLGTAYYIAPEVLRK--KYDEKCDVW 206 >3HZT-A nrPDB Length = 467 Score = 120 bits (301), Expect = 6e-28, Method: Composition-based stats. Identities = 35/177 (19%), Positives = 69/177 (38%), Gaps = 15/177 (8%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWL 106 + K + R +I + + T N LL ++ ++ L P ++ + +L Sbjct: 22 LCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYL 81 Query: 107 EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSN 166 + E GG F + + D A +++V LH ++ H DL N Sbjct: 82 --VMEVYRGGELFDEIILRQKFSEVD-----AAVIMKQVLSGTTYLHKHNIVHRDLKPEN 134 Query: 167 IVLVRDGARWTPHLIDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ++L ++DFGL + V ++++ Y + +L K+ EK + W Sbjct: 135 LLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLRK--KYDEKCDVW 189 >3LIJ-A nrPDB Length = 494 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 67/160 (41%), Gaps = 15/160 (9%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLK 123 T T + S+LL ++ ++ L P ++ +L + E GG F + Sbjct: 71 RKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYL--VMECYKGGELFDEII 128 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + + ++ D A +++V + LH ++ H DL N++L ++DF Sbjct: 129 HRMKFNEVD-----AAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDF 183 Query: 184 GLGSV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 GL +V ++++ Y + +L K+ EK + W Sbjct: 184 GLSAVFENQKKMKERLGTAYYIAPEVLRK--KYDEKCDVW 221 >3Q5I-A nrPDB Length = 504 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 70/188 (37%), Gaps = 16/188 (8%) Query: 39 LPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQL---I 95 L + K+ H + IK ++ + +E ++ L+ L P + Sbjct: 54 LCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY-NEISLLKSLDHPNIIKLF 112 Query: 96 ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN 155 + +L + E GG F + N + D A ++++ I LH + Sbjct: 113 DVFEDKKYFYL--VTEFYEGGELFEQIINRHKFDECD-----AANIMKQILSGICYLHKH 165 Query: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV---EDKGVDLYVLERAILSTHSK 212 + H D+ NI+L + ++DFGL S + D+ Y + +L K Sbjct: 166 NIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLKK--K 223 Query: 213 HAEKYNAW 220 + EK + W Sbjct: 224 YNEKCDVW 231 >3F3Z-A nrPDB Length = 277 Score = 100 bits (249), Expect = 7e-22, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 63/176 (35%), Gaps = 15/176 (8%) Query: 51 IKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLE 107 +K K R + + + K+ + R ++ ++ L P +I N I+L Sbjct: 25 VKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIRLYETFEDNTDIYL- 83 Query: 108 FLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNI 167 + E GG F + + + D A ++ V + H + H DL N Sbjct: 84 -VMELCTGGELFERVVHKRVFRESD-----AARIMKDVLSAVAYCHKLNVAHRDLKPENF 137 Query: 168 VLVRDGARWTPHLIDFGLG---SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + D LIDFGL ++ K Y + +L + + + W Sbjct: 138 LFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLE--GLYGPECDEW 191 >4MVF-A nrPDB Length = 506 Score = 99.4 bits (246), Expect = 1e-21, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 71/189 (37%), Gaps = 19/189 (10%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNLKN 124 + K R N +R ++ ++ L P ++ Y ++ + E G F ++ Sbjct: 88 KEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIE 147 Query: 125 FLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 +++ AT ++++ I LH + H DL N + + +IDFG Sbjct: 148 NGSFTEKN-----AATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFG 202 Query: 185 LGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQG 233 L K Y + +L K+ +K + W ++ G+ Y + Sbjct: 203 LSKNLGTGEFTTTKAGTPYYVAPQVLD--GKYDKKCDIWSSGVIMYTLLCGYPPFYGDTD 260 Query: 234 AKGAKKLKE 242 + KK+K+ Sbjct: 261 NEVLKKVKK 269 >2W4O-A nrPDB Length = 349 Score = 87.5 bits (215), Expect = 5e-18, Method: Composition-based stats. Identities = 47/237 (19%), Positives = 89/237 (37%), Gaps = 28/237 (11%) Query: 10 SSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPP-KRYRHPQIDQAL 68 ++ L PD I ++ A + F + L R S I YR K + P + L Sbjct: 34 TASLVPDYWIDGSNRDALSDFFEVESE--LGRGATS-----IVYRCKQKGTQKPYALKVL 86 Query: 69 TKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 K T+++ + ++ ++ L P +I + + + E + GG F + + Sbjct: 87 KK--TVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGY 144 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 ++D A ++++ + LH N H DL N++ + DFGL Sbjct: 145 YSERD-----AADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSK 199 Query: 188 VSN---LVEDKGVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQG 233 + L++ IL + + + W ++ GFE Y E+G Sbjct: 200 IVEHQVLMKTVCGTPGYCAPEILRG-CAYGPEVDMWSVGIITYILLCGFEPFYDERG 255 >2JAM-A nrPDB Length = 304 Score = 82.9 bits (203), Expect = 1e-16, Method: Composition-based stats. Identities = 32/194 (16%), Positives = 73/194 (37%), Gaps = 17/194 (8%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKN 124 + + K +S L ++ ++ + ++ D Y + + + GG F + Sbjct: 40 KCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILE 99 Query: 125 FLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 ++D + +++V + LH N H DL N++ + + DFG Sbjct: 100 RGVYTEKD-----ASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFG 154 Query: 185 LGSVSN--LVEDKGVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQGA 234 L + ++ + +L+ +++ + W ++ G+ Y E + Sbjct: 155 LSKMEQNGIMSTACGTPGYVAPEVLA-QKPYSKAVDCWSIGVITYILLCGYPPFYEETES 213 Query: 235 KGAKKLKEVTKRFE 248 K +K+KE FE Sbjct: 214 KLFEKIKEGYYEFE 227 >3IS5-A nrPDB Length = 285 Score = 77.5 bits (189), Expect = 5e-15, Method: Composition-based stats. Identities = 25/164 (15%), Positives = 56/164 (34%), Gaps = 8/164 (4%) Query: 62 PQIDQALTKHRT-LNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGF 119 ++ + + K R+ + ++ A++ ++ L P +I + + + + E GG Sbjct: 49 ERVIKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELL 108 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 + + VA ++++ + H H DL NI+ Sbjct: 109 ERIVSAQARGKA-LSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIK 167 Query: 180 LIDFGLGSVSNLVE---DKGVDLYVLERAILSTHSKHAEKYNAW 220 +IDFGL + E + + + K + W Sbjct: 168 IIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRDVTF--KCDIW 209 >3KN6-A nrPDB Length = 325 Score = 75.9 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 27/162 (16%), Positives = 61/162 (37%), Gaps = 13/162 (8%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNLKN 124 + ++K N + + L L G P ++ ++ + + E L GG F +K Sbjct: 42 KIISKRMEANTQKEITALKLCEG--HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKK 99 Query: 125 FLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + + + +RK+ + +H H DL N++ + +IDFG Sbjct: 100 KKHFSETE-----ASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFG 154 Query: 185 LGSV----SNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + + ++ L+ +L+ + + E + W + Sbjct: 155 FARLKPPDNQPLKTPCFTLHYAAPELLNQNG-YDESCDLWSL 195 >2JC6-A nrPDB Length = 334 Score = 74.0 bits (180), Expect = 6e-14, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 94/260 (36%), Gaps = 31/260 (11%) Query: 1 MTQEFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYR 60 M +E + SS+ DI I + E + + L K + + + +K P K + Sbjct: 2 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 61 Query: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGF 119 ES + ++ ++ + ++A D Y L + + + GG F Sbjct: 62 -------------GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELF 108 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 + + ++D +T +R+V + LH H DL N++ Sbjct: 109 DRIVEKGFYTEKD-----ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIM 163 Query: 180 LIDFGLGSVSNL---VEDKGVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEV 228 + DFGL + + + +L+ +++ + W ++ G+ Sbjct: 164 ISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA-QKPYSKAVDCWSIGVIAYILLCGYPPF 222 Query: 229 YREQGAKGAKKLKEVTKRFE 248 Y E +K +++ + F+ Sbjct: 223 YDENDSKLFEQILKAEYEFD 242 >3FXW-A nrPDB Length = 336 Score = 73.6 bits (179), Expect = 8e-14, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 56/152 (36%), Gaps = 16/152 (10%) Query: 94 LIACDP--YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL 151 ++ ++G L + E + GG FS ++ DQ A +R +G I Sbjct: 87 ILDVYENMHHGKRCLLIIMECMEGGELFSRIQER---GDQAFTEREAAEIMRDIGTAIQF 143 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG--SVSNLVEDKGVDLYVLERAILST 209 LH ++ H D+ N++ L DFG + N ++ Y + +L Sbjct: 144 LHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGP 203 Query: 210 HSKHAEKYNAW--------IMEGFEEVYREQG 233 K+ + + W ++ GF Y G Sbjct: 204 E-KYDKSCDMWSLGVIMYILLCGFPPFYSNTG 234 >2BDW-A nrPDB Length = 362 Score = 72.9 bits (177), Expect = 1e-13, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 54/156 (34%), Gaps = 20/156 (12%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ KL P ++ F +L F + + GG F ++ + Sbjct: 73 QKLEREARICRKLQ------HPNIVRLHDSIQEESFHYLVF--DLVTGGELFEDIVAREF 124 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ I H N H +L N++L L DFGL Sbjct: 125 YSEAD-----ASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAI 179 Query: 188 VSNLVE---DKGVDLYVLERAILSTHSKHAEKYNAW 220 N E L +L +++ + W Sbjct: 180 EVNDSEAWHGFAGTPGYLSPEVLKK-DPYSKPVDIW 214 >3KK8-A nrPDB Length = 284 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 54/156 (34%), Gaps = 20/156 (12%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ KL P ++ F +L F + + GG F ++ + Sbjct: 50 QKLEREARICRKLQ------HPNIVRLHDSIQEESFHYLVF--DLVTGGELFEDIVAREF 101 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ I H N H +L N++L L DFGL Sbjct: 102 YSEAD-----ASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAI 156 Query: 188 VSNLVE---DKGVDLYVLERAILSTHSKHAEKYNAW 220 N E L +L +++ + W Sbjct: 157 EVNDSEAWHGFAGTPGYLSPEVLKK-DPYSKPVDIW 191 >5FG8-A nrPDB Length = 285 Score = 72.5 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 52/157 (33%), Gaps = 21/157 (13%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ KL+ P ++ + +L F + + GG F ++ + Sbjct: 58 QKLEREARICRKLH------HPNIVRLHDSIQEENYHYLVF--DLVTGGELFEDIVAREF 109 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ + H N H DL N++L L DFGL Sbjct: 110 YSEAD-----ASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAI 164 Query: 188 VSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW 220 L +L + + + W Sbjct: 165 EVQGDHQAWFGFAGTPGYLSPEVLKKE-PYGKSVDIW 200 >2V7O-A nrPDB Length = 336 Score = 72.1 bits (175), Expect = 2e-13, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 72/206 (34%), Gaps = 25/206 (12%) Query: 51 IKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLE 107 +K P + Y I+ R + +L + + L P ++ GF +L Sbjct: 51 VKKTPTQEYAAKIINTKKLSAR--DHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 108 Query: 108 FLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNI 167 F + + GG F ++ + + D + + ++ + +H +D H DL N+ Sbjct: 109 F--DLVTGGELFEDIVAREYYSEAD-----ASHCIHQILESVNHIHQHDIVHRDLKPENL 161 Query: 168 VLVRDGARWTPHLIDFGLGSVSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW--- 220 +L L DFGL + L +L + + + W Sbjct: 162 LLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDIWACG 220 Query: 221 -----IMEGFEEVYREQGAKGAKKLK 241 ++ G+ + E K +++K Sbjct: 221 VILYILLVGYPPFWDEDQHKLYQQIK 246 >4YNZ-A nrPDB Length = 342 Score = 71.3 bits (173), Expect = 4e-13, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 63/166 (37%), Gaps = 15/166 (9%) Query: 62 PQIDQALTKHRTLNESRLL---AKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGH 117 ++ + L+ES L+ ++ ++ + P ++ D Y +L + E + GG Sbjct: 36 QKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGE 95 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F L + ++ R++ + H + CH DL N++L R Sbjct: 96 LFDYLVKKGRLTPKEARK-----FFRQIISALDFCHSHSICHRDLKPENLLLDE---RNN 147 Query: 178 PHLIDFGLGSVS---NLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + DFG+ S+ +L+E + ++ K + W Sbjct: 148 IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVW 193 >3MN3-A nrPDB Length = 271 Score = 71.3 bits (173), Expect = 4e-13, Method: Composition-based stats. Identities = 22/161 (13%), Positives = 52/161 (32%), Gaps = 11/161 (6%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNL 122 +I ++ + R+ ++ + L P +I + + G F + Sbjct: 35 KIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYI 94 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M +Q+ +++ + H + H DL N++L + D Sbjct: 95 VQRDKMSEQE-----ARRFFQQIISAVEYCHRHKIVHRDLKPENLLLDE---HLNVKIAD 146 Query: 183 FGLGSV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 FGL ++ N ++ ++S + + W Sbjct: 147 FGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVW 187 >3KA0-A nrPDB Length = 320 Score = 71.3 bits (173), Expect = 4e-13, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 55/153 (35%), Gaps = 17/153 (11%) Query: 94 LIACDP--YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL 151 ++ Y G L + E L GG FS +++ DQ + ++ +G I Sbjct: 74 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR---GDQAFTEREASEIMKSIGEAIQY 130 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---NLVEDKGVDLYVLERAILS 208 LH + H D+ N++ L DFG + N + + Y + +L Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLG 190 Query: 209 THSKHAEKYNAW--------IMEGFEEVYREQG 233 K+ + + W ++ G+ Y G Sbjct: 191 PE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHG 222 >2VN9-A nrPDB Length = 301 Score = 70.9 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 52/157 (33%), Gaps = 21/157 (13%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ L P ++ GF +L F + + GG F ++ + Sbjct: 48 QKLEREARICRLLK------HPNIVRLHDSISEEGFHYLVF--DLVTGGELFEDIVAREY 99 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ + H N H DL N++L L DFGL Sbjct: 100 YSEAD-----ASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAI 154 Query: 188 VSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW 220 + L +L + + + W Sbjct: 155 EVQGDQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDMW 190 >3HKO-A nrPDB Length = 345 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 65/203 (32%), Gaps = 47/203 (23%) Query: 64 IDQALTKHRTLNE-SRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSN 121 +++ + + R+ ++ L+ L P + Y ++ + E GGH Sbjct: 59 MNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDK 118 Query: 122 LKNFLWMHDQDPYSDLVAT-----------------------------------TLRKVG 146 L F+ D+V T +R++ Sbjct: 119 LNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIF 178 Query: 147 RQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED--------KGVD 198 + LH CH D+ N + + L+DFGL + + K Sbjct: 179 SALHYLHNQGICHRDIKPENFLF-STNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGT 237 Query: 199 LYVLERAILSTHSK-HAEKYNAW 220 Y + +L+T ++ + K +AW Sbjct: 238 PYFVAPEVLNTTNESYGPKCDAW 260 >4FG9-A nrPDB Length = 320 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 27/188 (14%), Positives = 70/188 (37%), Gaps = 22/188 (11%) Query: 75 NESRLLAKLYLIPGLCVPQLI---ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 E + ++ ++ + P ++ G ++L + + + GG F + + ++ Sbjct: 59 KEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYL--IMQLVSGGELFDRIVEKGFYTER 116 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN- 190 D + + +V + LH H DL N++ + DFGL + + Sbjct: 117 D-----ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDP 171 Query: 191 --LVEDKGVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQGAKGAKKL 240 ++ + +L+ +++ + W ++ G+ Y E AK +++ Sbjct: 172 GSVLSTACGTPGYVAPEVLA-QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQI 230 Query: 241 KEVTKRFE 248 + F+ Sbjct: 231 LKAEYEFD 238 >1NY3-A nrPDB Length = 400 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 54/153 (35%), Gaps = 17/153 (11%) Query: 94 LIACDP--YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL 151 ++ Y G L + E L GG FS +++ DQ + ++ +G I Sbjct: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR---GDQAFTEREASEIMKSIGEAIQY 176 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---NLVEDKGVDLYVLERAILS 208 LH + H D+ N++ L DFG + N + Y + +L Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 Query: 209 THSKHAEKYNAW--------IMEGFEEVYREQG 233 K+ + + W ++ G+ Y G Sbjct: 237 PE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 >6DTL-A nrPDB Length = 364 Score = 69.0 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 69/205 (33%), Gaps = 25/205 (12%) Query: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESR 78 I PI +GA IV + ++++ IK D + RTL E + Sbjct: 35 IMPIGKGAYGIVCSAMNS-------ETNESVAIKKIANA------FDNKIDAKRTLREIK 81 Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 LL + ++A + + + +Q + Sbjct: 82 LLRH------MDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHC 135 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV---SNLVEDK 195 L ++ R + +H + H DL SN++L A + DFGL V S+ + + Sbjct: 136 QYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NANCDLKICDFGLARVTSESDFMTEY 192 Query: 196 GVDLYVLERAILSTHSKHAEKYNAW 220 V + +L S + + W Sbjct: 193 VVTRWYRAPELLLNSSDYTAAIDVW 217 >2OZA-A nrPDB Length = 356 Score = 69.0 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 54/153 (35%), Gaps = 17/153 (11%) Query: 94 LIACDP--YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL 151 ++ Y G L + E L GG FS +++ DQ + ++ +G I Sbjct: 76 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR---GDQAFTEREASEIMKSIGEAIQY 132 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---NLVEDKGVDLYVLERAILS 208 LH + H D+ N++ L DFG + N + Y + +L Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 192 Query: 209 THSKHAEKYNAW--------IMEGFEEVYREQG 233 K+ + + W ++ G+ Y G Sbjct: 193 PE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHG 224 >3H4J-B nrPDB Length = 336 Score = 68.2 bits (165), Expect = 3e-12, Method: Composition-based stats. Identities = 22/157 (14%), Positives = 50/157 (31%), Gaps = 11/157 (7%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 ++ R+ ++ + L P +I + + GG F + Sbjct: 44 RQLLKKSDMHMRVEREISYLKLLRHPHIIKLYDVITTPTDIVMVIEYAGGELFDYIVEKK 103 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 M + D +++ I H + H DL N++L + + DFGL Sbjct: 104 RMTE-----DEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLDDN---LNVKIADFGLS 155 Query: 187 SV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ++ N ++ +++ + + W Sbjct: 156 NIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVW 192 >4NIF-A nrPDB Length = 333 Score = 68.2 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 47/140 (33%), Gaps = 16/140 (11%) Query: 91 VPQLI---ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGR 147 P +I ++L + E + GG + + +++ + L +G+ Sbjct: 61 HPNIITLKDVYDDGKHVYL--VTELMRGGELLDKILRQKFFSERE-----ASFVLHTIGK 113 Query: 148 QIGLLHWNDYCHGDLTSSNIVL-VRDGARWTPHLIDFGLGSV----SNLVEDKGVDLYVL 202 + LH H DL SNI+ G + DFG + L+ + Sbjct: 114 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 173 Query: 203 ERAILSTHSKHAEKYNAWIM 222 +L + E + W + Sbjct: 174 APEVLKRQG-YDEGCDIWSL 192 >2Y7J-A nrPDB Length = 365 Score = 67.9 bits (164), Expect = 4e-12, Method: Composition-based stats. Identities = 34/179 (18%), Positives = 66/179 (36%), Gaps = 24/179 (13%) Query: 51 IKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFL 109 I +R Q+++ + T E+ +L ++ P +I D Y ++ + Sbjct: 126 IMEVTAERLSPEQLEE--VREATRRETHILRQVA-----GHPHIITLIDSYESSSFMFLV 178 Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL 169 + + G F L + + +++ S +R + + LH N+ H DL NI+L Sbjct: 179 FDLMRKGELFDYLTEKVALSEKETRS-----IMRSLLEAVSFLHANNIVHRDLKPENILL 233 Query: 170 VRDGARWTPHLIDFGLG---SVSNLVEDKGVDLYVLERAIL-----STHSKHAEKYNAW 220 + L DFG + + L IL TH + ++ + W Sbjct: 234 DDNMQ---IRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLW 289 >3I6U-A nrPDB Length = 419 Score = 66.7 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 22/146 (15%), Positives = 48/146 (32%), Gaps = 10/146 (6%) Query: 82 KLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATT 141 ++ ++ L P +I + + E + GG F + + + Sbjct: 190 EIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFY--- 246 Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV---SNLVEDKGVD 198 ++ + LH N H DL N++L + DFG + ++L+ Sbjct: 247 --QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGT 304 Query: 199 LYVLERAILSTHSK--HAEKYNAWIM 222 L +L + + + W + Sbjct: 305 PTYLAPEVLVSVGTAGYNRAVDCWSL 330 >2YCR-A nrPDB Length = 323 Score = 66.3 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 22/146 (15%), Positives = 48/146 (32%), Gaps = 10/146 (6%) Query: 82 KLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATT 141 ++ ++ L P +I + + E + GG F + + + Sbjct: 65 EIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFY--- 121 Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV---SNLVEDKGVD 198 ++ + LH N H DL N++L + DFG + ++L+ Sbjct: 122 --QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGT 179 Query: 199 LYVLERAILSTHSK--HAEKYNAWIM 222 L +L + + + W + Sbjct: 180 PTYLAPEVLVSVGTAGYNRAVDCWSL 205 >1PHK-A nrPDB Length = 298 Score = 66.3 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 33/162 (20%), Positives = 56/162 (34%), Gaps = 26/162 (16%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLI---ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 + TL E +L K+ P +I N F +L F + + G F L + Sbjct: 67 REATLKEVDILRKVS-----GHPNIIQLKDTYETNTFFFLVF--DLMKKGELFDYLTEKV 119 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + +++ +R + I LH + H DL NI+L D L DFG Sbjct: 120 TLSEKETRK-----IMRALLEVICALHKLNIVHRDLKPENILLDDD---MNIKLTDFGFS 171 Query: 187 ---SVSNLVEDKGVDLYVLERAILS-----THSKHAEKYNAW 220 + + L I+ H + ++ + W Sbjct: 172 CQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMW 213 >4JG6-A nrPDB Length = 355 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 21/140 (15%), Positives = 47/140 (33%), Gaps = 16/140 (11%) Query: 91 VPQLI---ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGR 147 P +I ++++ + E + GG + + +++ + L + + Sbjct: 88 HPNIITLKDVYDDGKYVYV--VTELMKGGELLDKILRQKFFSERE-----ASAVLFTITK 140 Query: 148 QIGLLHWNDYCHGDLTSSNIVL-VRDGARWTPHLIDFGLGSV----SNLVEDKGVDLYVL 202 + LH H DL SNI+ G + + DFG + L+ + Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFV 200 Query: 203 ERAILSTHSKHAEKYNAWIM 222 +L + + W + Sbjct: 201 APEVLERQG-YDAACDIWSL 219 >4D28-A nrPDB Length = 446 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 21/149 (14%) Query: 81 AKLYLIPGLCVPQLIACDP-----YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 ++ ++ + P ++ +I LEF+ GG F + + + + Sbjct: 58 REISIMKIVRHPNIVRLYEVLASKSKIYIVLEFV----TGGELFDRIVHKGRLKE----- 108 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN----L 191 D +++ + H H DL N++L +G + DFGL ++ L Sbjct: 109 DESRKYFQQLVDAVAHCHSKGVYHRDLKPENLLLDTNG---NLKVSDFGLSALPQEGVEL 165 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + D + +LS + W Sbjct: 166 LNDTCGTPNYVAPEVLSGQGYDGSAADIW 194 >2YZA-A nrPDB Length = 276 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 23/166 (13%), Positives = 54/166 (32%), Gaps = 20/166 (12%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGH 117 +I ++ ++ + P +I P + F+ +E++ GG Sbjct: 42 KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYV----SGGE 97 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + + + +++ + H + H DL N++L A Sbjct: 98 LFDYICKHGRVEEME-----ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD---AHMN 149 Query: 178 PHLIDFGLGSV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + DFGL ++ + D ++S + + W Sbjct: 150 AKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIW 195 >3BHH-A nrPDB Length = 295 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 29/186 (15%), Positives = 62/186 (33%), Gaps = 29/186 (15%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ L ++ GF +L F + + GG F ++ + Sbjct: 48 QKLEREARICRLLK------HSNIVRLHDSISEEGFHYLVF--DLVTGGELFEDIVAREY 99 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ + H H DL N++L L DFGL Sbjct: 100 YSEAD-----ASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAI 154 Query: 188 VSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQGAK 235 + L +L + + + + W ++ G+ + E K Sbjct: 155 EVQGDQQAWFGFAGTPGYLSPEVLRKEA-YGKPVDIWACGVILYILLVGYPPFWDEDQHK 213 Query: 236 GAKKLK 241 +++K Sbjct: 214 LYQQIK 219 >5IG1-A nrPDB Length = 344 Score = 64.8 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 28/195 (14%), Positives = 65/195 (33%), Gaps = 22/195 (11%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIAC---DPYNGFIWLEFLGEDLPGGHGFSNLK 123 AL R+ +++ ++ + L +++ +L F E + GG F + Sbjct: 51 ALKSLRSSEINKIKREIGICSSLQHEHIVSMRRAFRDESHFYLVF--EYVSGGELFDEIV 108 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + +++D + + ++ + H + H DL N++L + DF Sbjct: 109 TRKFYNEKD-----ASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDF 163 Query: 184 GLGSVSNLVEDK---GVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQ 232 GL + L ++ + + W ++ G+ + E Sbjct: 164 GLAVIMEQGPTYFGFAGTPGYLSPEVIR-RVPYDTAVDVWACGVILYILLVGYPPFWEED 222 Query: 233 GAKGAKKLKEVTKRF 247 K ++K F Sbjct: 223 HQKLYAQIKNCQYDF 237 >4CQG-A nrPDB Length = 331 Score = 64.8 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 26/153 (16%), Positives = 53/153 (34%), Gaps = 18/153 (11%) Query: 78 RLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 R+ ++ + L + I++ + E PGG F + + + +++ Sbjct: 53 RVKTEIDALKSLRHQHICQLYHVLETKNKIFM--VLEYCPGGELFDYIISQDRLSEEETR 110 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 R++ + +H Y H DL N++ + LIDFGL + +D Sbjct: 111 V-----VFRQILSAVAYVHSQGYAHRDLKPENLLFDENHK---LKLIDFGLCAKPKGNKD 162 Query: 195 K-----GVDLYVLERAILSTHSKHAEKYNAWIM 222 L ++ S + + W M Sbjct: 163 YHLQECCGSLAYAAPELIQGKSYLGSEADVWSM 195 >5DBX-A nrPDB Length = 328 Score = 64.4 bits (155), Expect = 4e-11, Method: Composition-based stats. Identities = 33/169 (19%), Positives = 64/169 (37%), Gaps = 21/169 (12%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLK 123 L K +T + LL ++ + P ++ +WL + + L GG +K Sbjct: 45 NLEKCQTSMD-ELLKEIQAMSQCSHPNVVTYYTSFVVKDELWL--VMKLLSGGSMLDIIK 101 Query: 124 ---NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 N + ++AT L++V + LH N H DL + NI+L G + + Sbjct: 102 YIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILL---GEDGSVQI 158 Query: 181 IDFGLG---------SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 DFG+ + + + +D + ++ + K + W Sbjct: 159 ADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMW 207 >3GUB-A nrPDB Length = 295 Score = 64.4 bits (155), Expect = 4e-11, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 67/173 (38%), Gaps = 18/173 (10%) Query: 41 RAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP- 99 R K + +Y K+ +R + + R ++ + ++ ++ + P +I Sbjct: 31 REKSTGLQYAAKFIKKRRTKSSR--------RGVSREDIEREVSILKEIQHPNVITLHEV 82 Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 Y + +GE + GG F L + +++ L+++ + LH H Sbjct: 83 YENKTDVILIGELVAGGELFDFLAEKESLTEEE-----ATEFLKQILNGVYYLHSLQIAH 137 Query: 160 GDLTSSNI-VLVRDGARWTPHLIDFGLG---SVSNLVEDKGVDLYVLERAILS 208 DL NI +L R+ + +IDFGL N ++ + I++ Sbjct: 138 FDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVN 190 >4RED-A nrPDB Length = 351 Score = 64.0 bits (154), Expect = 6e-11, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 56/169 (33%), Gaps = 26/169 (15%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGH 117 +I ++ ++ + P +I P + F+ +E++ GG Sbjct: 45 KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYV----SGGE 100 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + +++ +++ + H + H DL N++L A Sbjct: 101 LFDYICKNGRLDEKESR-----RLFQQILSGVDYCHRHMVVHRDLKPENVLLD---AHMN 152 Query: 178 PHLIDFGLGSVSNLVED------KGVDLYVLERAILSTHSKHAEKYNAW 220 + DFGL SN++ D ++S + + W Sbjct: 153 AKIADFGL---SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 198 >5ES1-A nrPDB Length = 328 Score = 64.0 bits (154), Expect = 7e-11, Method: Composition-based stats. Identities = 25/163 (15%), Positives = 57/163 (34%), Gaps = 14/163 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNL 122 ID+ +L +L ++ ++ GL P ++ L + E G F L Sbjct: 48 IDKTQLNPSSLQ--KLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYL 105 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 + M +++ + R++ + H + H DL + N++L A + D Sbjct: 106 VSHGRMKEKEARAK-----FRQIVSAVHYCHQKNIVHRDLKAENLLLD---AEANIKIAD 157 Query: 183 FGLG---SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG ++ + ++ + + + W + Sbjct: 158 FGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSL 200 >4REW-A nrPDB Length = 540 Score = 63.6 bits (153), Expect = 8e-11, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 56/169 (33%), Gaps = 26/169 (15%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGH 117 +I ++ ++ + P +I P + F+ +E++ GG Sbjct: 37 KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYV----SGGE 92 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + +++ +++ + H + H DL N++L A Sbjct: 93 LFDYICKNGRLDEKESR-----RLFQQILSGVDYCHRHMVVHRDLKPENVLLD---AHMN 144 Query: 178 PHLIDFGLGSVSNLVED------KGVDLYVLERAILSTHSKHAEKYNAW 220 + DFGL SN++ D ++S + + W Sbjct: 145 AKIADFGL---SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 190 >4CFF-A nrPDB Length = 571 Score = 63.6 bits (153), Expect = 9e-11, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 55/169 (32%), Gaps = 26/169 (15%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGH 117 +I ++ ++ + P +I P + F+ +E++ GG Sbjct: 64 KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYV----SGGE 119 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + + + +++ + H + H DL N++L A Sbjct: 120 LFDYICKHGRVEEME-----ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD---AHMN 171 Query: 178 PHLIDFGLGSVSNLVED------KGVDLYVLERAILSTHSKHAEKYNAW 220 + DFGL SN++ D ++S + + W Sbjct: 172 AKIADFGL---SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 >2HW6-A nrPDB Length = 307 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 27/176 (15%), Positives = 60/176 (34%), Gaps = 26/176 (14%) Query: 66 QALTKHRTLNESRLLAKLYLIPGL----CVPQLIACDPYNGFIWLEFLGEDLPGGHGFSN 121 + + K + SR+ ++ + + +LI + +L F E L GG ++ Sbjct: 44 KIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVF--EKLQGGSILAH 101 Query: 122 LKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI 181 ++ ++++ + +R V + LH H DL NI+ + Sbjct: 102 IQKQKHFNERE-----ASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKIC 156 Query: 182 DFGLGSVSNLVED-----------KGVDLYVLERAILSTHSK----HAEKYNAWIM 222 DF LGS L + ++ + + ++ + W + Sbjct: 157 DFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSL 212 >2BRG-A nrPDB Length = 297 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 52/147 (35%), Gaps = 15/147 (10%) Query: 81 AKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDL-PGGHGFSNLKNFLWMHDQDPYSDLVA 139 ++ + L ++ + +++L + GG F ++ + M + D Sbjct: 54 KEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPD-----AQ 108 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV------SNLVE 193 ++ + LH H D+ N++L R + DFGL +V L+ Sbjct: 109 RFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---RDNLKISDFGLATVFRYNNRERLLN 165 Query: 194 DKGVDLYVLERAILSTHSKHAEKYNAW 220 L + +L HAE + W Sbjct: 166 KMCGTLPYVAPELLKRREFHAEPVDVW 192 >6C9D-A nrPDB Length = 459 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 56/163 (34%), Gaps = 14/163 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNL 122 ID+ +L +L ++ ++ L P ++ L + E GG F L Sbjct: 54 IDKTQLNPTSLQ--KLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL 111 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M +++ + R++ + H H DL + N++L D + D Sbjct: 112 VAHGRMKEKEARAK-----FRQIVSAVQYCHQKYIVHRDLKAENLLLDGD---MNIKIAD 163 Query: 183 FGLG---SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG +V N +++ + + + W + Sbjct: 164 FGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEVDVWSL 206 >4CZT-A nrPDB Length = 464 Score = 62.9 bits (151), Expect = 1e-10, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 60/169 (35%), Gaps = 26/169 (15%) Query: 66 QALTKHRTLNE---SRLLAKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGH 117 + + K + L +++ ++ + + P +I + LEF+ GG Sbjct: 42 KVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFV----TGGE 97 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + + + D +++ + H H DL N++L +GA Sbjct: 98 LFDKISSNGRLKE-----DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDANGA--- 149 Query: 178 PHLIDFGLGSVSNLVEDKG------VDLYVLERAILSTHSKHAEKYNAW 220 + DFGL ++ V + G + +++ K + W Sbjct: 150 LKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLW 198 >2VZ6-A nrPDB Length = 313 Score = 62.9 bits (151), Expect = 1e-10, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 50/157 (31%), Gaps = 21/157 (13%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ L P ++ G +L F + + GG F ++ + Sbjct: 66 QKLEREARICRLLK------HPNIVRLHDSISEEGHHYLIF--DLVTGGELFEDIVAREY 117 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ + H H DL N++L L DFGL Sbjct: 118 YSEAD-----ASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAI 172 Query: 188 VSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW 220 + L +L + + + W Sbjct: 173 EVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLW 208 >5KZ7-A nrPDB Length = 346 Score = 62.9 bits (151), Expect = 1e-10, Method: Composition-based stats. Identities = 26/163 (15%), Positives = 54/163 (33%), Gaps = 14/163 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNL 122 ID+ +L +L ++ ++ L P ++ L + E GG F L Sbjct: 66 IDKTQLNSSSLQ--KLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL 123 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M +++ + R++ + H H DL + N++L A + D Sbjct: 124 VAHGRMKEKEARAK-----FRQIVSAVQYCHQKFIVHRDLKAENLLLD---ADMNIKIAD 175 Query: 183 FGLG---SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG + N ++ + + + W + Sbjct: 176 FGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 218 >5EZV-A nrPDB Length = 560 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 55/169 (32%), Gaps = 26/169 (15%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGH 117 +I ++ ++ + P +I P + F+ +E++ GG Sbjct: 59 KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYV----SGGE 114 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + + + +++ + H + H DL N++L A Sbjct: 115 LFDYICKHGRVEEME-----ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLD---AHMN 166 Query: 178 PHLIDFGLGSVSNLVED------KGVDLYVLERAILSTHSKHAEKYNAW 220 + DFGL SN++ D ++S + + W Sbjct: 167 AKIADFGL---SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 212 >5U6Y-A nrPDB Length = 461 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 50/157 (31%), Gaps = 21/157 (13%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ L P ++ G +L F + + GG F ++ + Sbjct: 44 QKLEREARICRLLK------HPNIVRLHDSISEEGHHYLIF--DLVTGGELFEDIVAREY 95 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ + H H DL N++L L DFGL Sbjct: 96 YSEAD-----ASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAI 150 Query: 188 VSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW 220 + L +L + + + W Sbjct: 151 EVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLW 186 >4CFH-A nrPDB Length = 493 Score = 62.5 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 56/169 (33%), Gaps = 26/169 (15%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGH 117 +I ++ ++ + P +I P + F+ +E++ GG Sbjct: 64 KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYV----SGGE 119 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + + +++ +++ + H + H DL N++L A Sbjct: 120 LFDYICKNGRLDEKESR-----RLFQQILSGVDYCHRHMVVHRDLKPENVLLD---AHMN 171 Query: 178 PHLIDFGLGSVSNLVED------KGVDLYVLERAILSTHSKHAEKYNAW 220 + DFGL SN++ D ++S + + W Sbjct: 172 AKIADFGL---SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 >2QNJ-A nrPDB Length = 328 Score = 62.1 bits (149), Expect = 2e-10, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 54/163 (33%), Gaps = 14/163 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNL 122 ID+ +L +L ++ ++ L P ++ L + E GG F L Sbjct: 45 IDKTQLNPTSLQ--KLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYL 102 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M +++ S R++ + H H DL + N++L A + D Sbjct: 103 VAHGRMKEKEARSK-----FRQIVSAVQYCHQKRIVHRDLKAENLLLD---ADMNIKIAD 154 Query: 183 FGLG---SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG +V ++ + + + W + Sbjct: 155 FGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 197 >2HAK-A nrPDB Length = 328 Score = 62.1 bits (149), Expect = 2e-10, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 55/163 (33%), Gaps = 14/163 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNL 122 ID+ +L +L ++ ++ L P ++ L + E GG F L Sbjct: 48 IDKTQLNPTSLQ--KLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYL 105 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M +++ + R++ + H H DL + N++L D + D Sbjct: 106 VAHGRMKEKEARAK-----FRQIVSAVQYCHQKYIVHRDLKAENLLLDGD---MNIKIAD 157 Query: 183 FGLG---SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG +V N ++ + + + W + Sbjct: 158 FGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSL 200 >2YAB-A nrPDB Length = 361 Score = 62.1 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 59/148 (39%), Gaps = 15/148 (10%) Query: 41 RAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DP 99 R K + +Y K+ ++ R + + + + E +L ++ P +I D Sbjct: 32 REKSTGLEYAAKFIKKRQSRASR--RGVCREEIEREVSILRQVL------HPNIITLHDV 83 Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 Y + + E + GG F L + +++ + ++++ + LH H Sbjct: 84 YENRTDVVLILELVSGGELFDFLAQKESLSEEE-----ATSFIKQILDGVNYLHTKKIAH 138 Query: 160 GDLTSSNI-VLVRDGARWTPHLIDFGLG 186 DL NI +L ++ LIDFGL Sbjct: 139 FDLKPENIMLLDKNIPIPHIKLIDFGLA 166 >2J90-A nrPDB Length = 304 Score = 61.7 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 65/173 (37%), Gaps = 18/173 (10%) Query: 41 RAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DP 99 R K + ++Y K+ +R + + +++ E +L ++ P +I D Sbjct: 46 RQKGTGKEYAAKFIKKRRLSSSR--RGVSREEIEREVNILREIR------HPNIITLHDI 97 Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 + + + E + GG F L + + D L+++ + LH H Sbjct: 98 FENKTDVVLILELVSGGELFDFLAEKESLTE-----DEATQFLKQILDGVHYLHSKRIAH 152 Query: 160 GDLTSSNI-VLVRDGARWTPHLIDFGLG---SVSNLVEDKGVDLYVLERAILS 208 DL NI +L ++ LIDFG+ N ++ + I++ Sbjct: 153 FDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVN 205 >3SOA-A nrPDB Length = 444 Score = 61.7 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 24/157 (15%), Positives = 50/157 (31%), Gaps = 21/157 (13%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 + E+R+ L P ++ G +L F + + GG F ++ + Sbjct: 55 QKLEREARICRLLK------HPNIVRLHDSISEEGHHYLIF--DLVTGGELFEDIVAREY 106 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + D + ++++ + H H +L N++L L DFGL Sbjct: 107 YSEAD-----ASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAI 161 Query: 188 VSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW 220 + L +L + + + W Sbjct: 162 EVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLW 197 >1V0B-A nrPDB Length = 288 Score = 61.3 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 30/181 (16%), Positives = 60/181 (33%), Gaps = 19/181 (10%) Query: 49 YIIKYRPPKRYRHPQIDQALTKHRTLN--ESRLLAKLYLIPGLCVPQLIACDP---YNGF 103 Y + Y+ Y + + + S + ++ ++ L ++ Sbjct: 15 YGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDVIHTKKR 74 Query: 104 IWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLT 163 + L F H +LK L + + S + L ++ I H H DL Sbjct: 75 LVLVF-------EHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLK 127 Query: 164 SSNIVLVRDGARWTPHLIDFGLGSV----SNLVEDKGVDLYVLERAILSTHSKHAEKYNA 219 N+++ R+G + DFGL + V L+ +L K++ + Sbjct: 128 PQNLLINREGE---LKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDI 184 Query: 220 W 220 W Sbjct: 185 W 185 >4D2V-A nrPDB Length = 356 Score = 61.3 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 26/153 (16%), Positives = 52/153 (33%), Gaps = 18/153 (11%) Query: 78 RLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 R+ ++ + L + I++ + E PGG F + + + +++ Sbjct: 73 RIKTEIEALKNLRHQHICQLYHVLETANKIFM--VLEYCPGGELFDYIISQDRLSEEETR 130 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 R++ + +H Y H DL N++ LIDFGL + +D Sbjct: 131 V-----VFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHK---LKLIDFGLCAKPKGNKD 182 Query: 195 K-----GVDLYVLERAILSTHSKHAEKYNAWIM 222 L ++ S + + W M Sbjct: 183 YHLQACCGALAYAAPELIQGKSYLGSEADVWSM 215 >3DAK-A nrPDB Length = 290 Score = 61.3 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 31/169 (18%), Positives = 64/169 (37%), Gaps = 21/169 (12%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLK 123 L K +T + LL ++ + P +++ +WL + + L GG +K Sbjct: 44 NLEKCQTSMD-ELLKEIQAMSQCHHPNIVSYYTSFVVKDELWL--VMKLLSGGSVLDIIK 100 Query: 124 NFLWMHDQDP---YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + + + +AT LR+V + LH N H D+ + NI+L G + + Sbjct: 101 HIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILL---GEDGSVQI 157 Query: 181 IDFGLG---------SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 DFG+ + + + + + ++ + K + W Sbjct: 158 ADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIW 206 >4B8L-A nrPDB Length = 286 Score = 59.8 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 38/211 (18%), Positives = 76/211 (36%), Gaps = 35/211 (16%) Query: 16 DVDIA-PISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTL 74 D DI P+ +G V+ A++ K+I+ + Q+++ +H+ Sbjct: 16 DFDIGRPLGKGKFGNVYL---------AREKQNKFIMALKV---LFKSQLEKEGVEHQ-- 61 Query: 75 NESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 L ++ + L P ++ Y I+L E P G + L+ +Q Sbjct: 62 ----LRREIEIQSHLRHPNILRMYNYFHDRKRIYLML--EFAPRGELYKELQKHGRFDEQ 115 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL 191 AT + ++ + H H D+ N+++ G + + DFG + Sbjct: 116 RS-----ATFMEELADALHYCHERKVIHRDIKPENLLM---GYKGELKIADFGWSVHAPS 167 Query: 192 VEDKG--VDLYVLERAILSTHSKHAEKYNAW 220 + + L L ++ H EK + W Sbjct: 168 LRRRTMCGTLDYLPPEMIEGK-THDEKVDLW 197 >3M42-A nrPDB Length = 299 Score = 59.0 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 26/112 (23%), Positives = 44/112 (39%), Gaps = 6/112 (5%) Query: 94 LIACDP--YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL 151 ++ Y G L + E L GG FS +++ DQ + ++ +G I Sbjct: 76 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR---GDQAFTEREASEIMKSIGEAIQY 132 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE-DKGVDLYVL 202 LH + H D+ N++ L DFG + + DK D++ L Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEKYDKSCDMWSL 184 >4EWQ-A nrPDB Length = 383 Score = 59.0 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 6/145 (4%) Query: 78 RLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 R +L L+ + +I D + LE + H N + + Q D Sbjct: 90 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDD 148 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VSNLVEDK 195 V + ++ R + +H D H DL SN+ + D ++DFGL + + Sbjct: 149 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMTGY 205 Query: 196 GVDLYVLERAILSTHSKHAEKYNAW 220 + I+ + + + W Sbjct: 206 VATRWYRAPEIMLNWMHYNQTVDIW 230 >3LM0-A nrPDB Length = 327 Score = 59.0 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 33/168 (19%), Positives = 59/168 (35%), Gaps = 14/168 (8%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNESRL-----LAKLYLIPGLC-VPQLIACDPYNGF 103 +++ K + L K R + R +A L L V L Sbjct: 44 VVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSE 103 Query: 104 IWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLT 163 I L + E GG FS + + +D++ ++++ + LH N+ H DL Sbjct: 104 IIL--ILEYAAGGEIFS--LCLPELAEMVSENDVI-RLIKQILEGVYYLHQNNIVHLDLK 158 Query: 164 SSNIVLVRDGARWTPHLIDFGLGSV---SNLVEDKGVDLYVLERAILS 208 NI+L ++DFG+ + + + L IL+ Sbjct: 159 PQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILN 206 >5WAX-A nrPDB Length = 310 Score = 59.0 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 50/168 (29%), Gaps = 27/168 (16%) Query: 60 RHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPG 115 R +ID+ + ++ L P +I + I L + E G Sbjct: 46 RGEKIDENVQ-----------REIINHRSLRHPNIIR---FKEVILTPTHLAIVMEYASG 91 Query: 116 GHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR 175 G F + N + D +++ + H CH DL N +L A Sbjct: 92 GELFERICNAGRFSE-----DEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAP 146 Query: 176 WTPHLIDFGLGSVSNLV---EDKGVDLYVLERAILSTHSKHAEKYNAW 220 + DFG S L + + +L + + W Sbjct: 147 -RLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVW 193 >3D2K-A nrPDB Length = 272 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 80/213 (37%), Gaps = 35/213 (16%) Query: 16 DVDIA-PISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTL 74 D DI P+ +G V YL R + S K+I+ + Q+++A +H+ Sbjct: 13 DFDIGRPLGKGKFGNV-------YLARERQS--KFILALKV---LFKTQLEKAGVEHQ-- 58 Query: 75 NESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 L ++ + L P ++ Y ++L + E P G + L+ +Q Sbjct: 59 ----LRREVEIQSHLRHPNILRLYGYFHDATRVYL--ILEYAPLGTVYRELQKLSRFDEQ 112 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG--SVS 189 AT + ++ + H H D+ N++L +G + DFG + S Sbjct: 113 RT-----ATYITELANALSYCHSKRVIHRDIKPENLLLGSNGE---LKIADFGWSVHAPS 164 Query: 190 NLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + L L ++ H EK + W + Sbjct: 165 SRRTTLCGTLDYLPPEMIEGR-MHDEKVDLWSL 196 >2A27-A nrPDB Length = 321 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 59/148 (39%), Gaps = 15/148 (10%) Query: 41 RAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DP 99 R K + +Y K+ ++ R + R ++ + ++ ++ + +I D Sbjct: 32 REKSTGLEYAAKFIKKRQSRASR--------RGVSREEIEREVSILRQVLHHNVITLHDV 83 Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 Y + + E + GG F L + +++ + ++++ + LH H Sbjct: 84 YENRTDVVLILELVSGGELFDFLAQKESLSEEE-----ATSFIKQILDGVNYLHTKKIAH 138 Query: 160 GDLTSSNI-VLVRDGARWTPHLIDFGLG 186 DL NI +L ++ LIDFGL Sbjct: 139 FDLKPENIMLLDKNIPIPHIKLIDFGLA 166 >6CKI-A nrPDB Length = 316 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 46/135 (34%), Gaps = 22/135 (16%) Query: 103 FIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDL 162 +L F E + GG S++ ++ + + ++ V + LH H DL Sbjct: 85 RFYLVF--EKMRGGSILSHIHKRRHFNELE-----ASVVVQDVASALDFLHNKGIAHRDL 137 Query: 163 TSSNIVLVRDGARWTPHLIDFGLGSVSNLVED-----------KGVDLYVLERAILSTHS 211 NI+ + DFGLGS L D + ++ S Sbjct: 138 KPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFS 197 Query: 212 K----HAEKYNAWIM 222 + + ++ + W + Sbjct: 198 EEASIYDKRCDLWSL 212 >5YKS-A nrPDB Length = 377 Score = 58.6 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 30/158 (18%), Positives = 48/158 (30%), Gaps = 10/158 (6%) Query: 69 TKHRTLNESRLLAKLYLIPGLCVPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNLKNFLW 127 TK TL L ++ + + P ++ + L + E GG F + Sbjct: 71 TKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMK--- 127 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG- 186 H++ DL ++ I H H DL N+V + L DFG Sbjct: 128 -HEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFE--KQGLVKLTDFGFSN 184 Query: 187 --SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + L IL A + W + Sbjct: 185 KFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSL 222 >4WNO-A nrPDB Length = 287 Score = 58.2 bits (139), Expect = 3e-09, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 62/169 (36%), Gaps = 28/169 (16%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNG-----FIWLEFLGEDLPGGHGFS 120 + L K +TL L ++ ++ L ++A + ++ +E+ GG Sbjct: 55 KNLAKSQTL----LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCN----GGDLAD 106 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRD-GARWTP- 178 L + + D + L+++ + LLH H DL NI+L G R P Sbjct: 107 YLHAMRTLSE-----DTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPN 161 Query: 179 ----HLIDFGLGSV--SNLVEDKG-VDLYVLERAILSTHSKHAEKYNAW 220 + DFG SN++ + ++ + + K + W Sbjct: 162 SIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQH-YDGKADLW 209 >1ZWS-A nrPDB Length = 288 Score = 58.2 bits (139), Expect = 3e-09, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 59/148 (39%), Gaps = 15/148 (10%) Query: 41 RAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DP 99 R K + +Y K+ ++ R + R ++ + ++ ++ + +I D Sbjct: 32 REKSTGLEYAAKFIKKRQSRASR--------RGVSREEIEREVSILRQVLHHNVITLHDV 83 Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 Y + + E + GG F L + +++ + ++++ + LH H Sbjct: 84 YENRTDVVLILELVSGGELFDFLAQKESLSEEE-----ATSFIKQILDGVNYLHTKKIAH 138 Query: 160 GDLTSSNI-VLVRDGARWTPHLIDFGLG 186 DL NI +L ++ LIDFGL Sbjct: 139 FDLKPENIMLLDKNIPIPHIKLIDFGLA 166 >2W96-B nrPDB Length = 306 Score = 58.2 bits (139), Expect = 3e-09, Method: Composition-based stats. Identities = 49/220 (22%), Positives = 85/220 (38%), Gaps = 26/220 (11%) Query: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESR 78 +A I GA V+ +A+D H + + K R P ++ L T+ E Sbjct: 9 VAEIGVGAYGTVY---------KARDPHSGHFVAL---KSVRVPNGEEGLPIS-TVREVA 55 Query: 79 LLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFL-WMHDQDPYSD 136 LL +L P ++ D + L H +L+ +L ++ Sbjct: 56 LLRRLE---AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE 112 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN---LVE 193 + +R+ R + LH N H DL NI++ G T L DFGL + + ++ Sbjct: 113 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGG---TVKLADFGLARIYSYQMALD 169 Query: 194 DKGVDLYVLERAILSTHSKHAEKYNAWIMEG-FEEVYREQ 232 V L+ +L S +A + W + F E++R + Sbjct: 170 PVVVTLWYRAPEVL-LQSTYATPVDMWSVGCIFAEMFRRK 208 >4QTB-A nrPDB Length = 380 Score = 58.2 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 31/214 (14%), Positives = 68/214 (31%), Gaps = 19/214 (8%) Query: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKY---RPPKRYRHPQIDQALTKHRTLNE-- 76 + G V P+ + + +YI + Y H + + K + E Sbjct: 21 VGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQ 80 Query: 77 ---SRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 R L ++ ++ +I LE + + + + Q Sbjct: 81 TYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLM-ETDLYKLLKSQQL 139 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 +D + L ++ R + +H + H DL SN+++ + DFGL +++ Sbjct: 140 SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEH 196 Query: 194 DKGV-------DLYVLERAILSTHSKHAEKYNAW 220 D + I+ + + + W Sbjct: 197 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW 230 >3OHT-A nrPDB Length = 389 Score = 58.2 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 50/145 (34%), Gaps = 6/145 (4%) Query: 78 RLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 R +L L+ + +I D + LE + H N + + Q D Sbjct: 96 RTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDD 154 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VSNLVEDK 195 V + ++ R + +H D H DL SN+ + D ++DFGL + + Sbjct: 155 HVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCE---LKILDFGLARHTDDEMTGY 211 Query: 196 GVDLYVLERAILSTHSKHAEKYNAW 220 + I+ + + W Sbjct: 212 VATRWYRAPEIMLNWMHYNMTVDIW 236 >3UC3-A nrPDB Length = 361 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 30/212 (14%), Positives = 63/212 (29%), Gaps = 18/212 (8%) Query: 17 VDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNE 76 +D AP++ G + + Y + + + + + + Sbjct: 1 MDRAPVTTGPLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID 60 Query: 77 SRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPGGHGFSNLKNFLWMHDQD 132 + ++ L P ++ + I L + E GG + + N + Sbjct: 61 ENVQREIINHRSLRHPNIVR---FKEVILTPTHLAIIMEYASGGELYERICNAGRFSE-- 115 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 D +++ + H CH DL N +L A + DFG S L Sbjct: 116 ---DEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAP-RLKICDFGYSKSSVLH 171 Query: 193 ---EDKGVDLYVLERAILSTHSKHAEKY-NAW 220 + + +L ++ K + W Sbjct: 172 SQPKSTVGTPAYIAPEVL-LRQEYDGKIADVW 202 >5AWM-A nrPDB Length = 394 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 42/211 (19%), Positives = 72/211 (34%), Gaps = 35/211 (16%) Query: 17 VDIAPISQGAEAIV---FTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRT 73 +++ PI GA+ IV + T T + K S RP + H + Sbjct: 47 INLRPIGSGAQGIVCAAYDTITQQNVAIKKLS--------RPFQNVTHAK---------- 88 Query: 74 LNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 R + L+ + +I + + LE + N + D Sbjct: 89 ----RAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMD--ANLCQVIQMD 142 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN-- 190 D ++ L ++ I LH H DL SNIV+ A T ++DFGL + Sbjct: 143 LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---ADCTLKILDFGLARTAGTT 199 Query: 191 -LVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ++ V Y ++ + E + W Sbjct: 200 FMMTPYVVTRYYRAPEVILGMG-YTENVDIW 229 >3E7O-A nrPDB Length = 360 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 71/209 (33%), Gaps = 35/209 (16%) Query: 19 IAPISQGAEAIV---FTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLN 75 + PI GA+ IV F T + K S RP + H + Sbjct: 27 LKPIGSGAQGIVCAAFDTVLGINVAVKKLS--------RPFQNQTHAK------------ 66 Query: 76 ESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 R +L L+ + +I+ + + LE + + + D Sbjct: 67 --RAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHE 124 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN---L 191 ++ L ++ I LH H DL SNIV+ D T ++DFGL ++ + Sbjct: 125 R--MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD---CTLKILDFGLARTASTNFM 179 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + V Y ++ + E + W Sbjct: 180 MTPYVVTRYYRAPEVILGMG-YKENVDIW 207 >4KRC-A nrPDB Length = 317 Score = 57.8 bits (138), Expect = 5e-09, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 52/153 (33%), Gaps = 16/153 (10%) Query: 77 SRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 S + ++ L+ L ++ + EF+ DL + N + Sbjct: 48 STAIREISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLEL 107 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV--- 188 + LV ++ + + H N H DL N+++ + G L DFGL Sbjct: 108 N----LVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQ---LKLGDFGLARAFGI 160 Query: 189 -SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 N + V L+ +L ++ + W Sbjct: 161 PVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIW 193 >1JNK-A nrPDB Length = 423 Score = 57.5 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 71/207 (34%), Gaps = 29/207 (14%) Query: 18 DIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNES 77 ++ PI GA+ IV A D+ + + + + Q T + Sbjct: 66 NLKPIGSGAQGIVCA---------AYDAVLDRNVAIK-----KLSRPFQNQTHAK----- 106 Query: 78 RLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 R +L L+ + +I+ + + LE + + + D Sbjct: 107 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER- 165 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---VSNLVE 193 ++ L ++ I LH H DL SNIV+ D T ++DFGL S ++ Sbjct: 166 -MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD---CTLKILDFGLARTAGTSFMMT 221 Query: 194 DKGVDLYVLERAILSTHSKHAEKYNAW 220 V Y ++ + E + W Sbjct: 222 PYVVTRYYRAPEVILGMG-YKENVDIW 247 >6GU6-A nrPDB Length = 302 Score = 57.5 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 28/151 (18%), Positives = 57/151 (37%), Gaps = 15/151 (9%) Query: 77 SRLLAKLYLIPGLCVPQLI---ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 S + ++ L+ L P ++ + ++L F + ++ +M Sbjct: 51 STAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMD---- 106 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV----S 189 S LV + L ++ + I H H DL N+++ G T L DFGL Sbjct: 107 -SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG---TIKLADFGLARAFGIPI 162 Query: 190 NLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + V L+ +L ++++ + W Sbjct: 163 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 193 >5JZN-A nrPDB Length = 280 Score = 57.5 bits (137), Expect = 6e-09, Method: Composition-based stats. Identities = 26/175 (14%), Positives = 63/175 (36%), Gaps = 10/175 (5%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRT-LNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLE 107 ++K + + + K + E + ++ ++ + P ++ + + L Sbjct: 34 VVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELY 93 Query: 108 FLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSN- 166 + E + GG F + + ++D + L + I LH + H D+ N Sbjct: 94 LVMELVKGGDLFDAITSTNKYTERD-----ASGMLYNLASAIKYLHSLNIVHRDIKPENL 148 Query: 167 IVLVRDGARWTPHLIDFGLGSVSN-LVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +V + L DFGL ++ + + + I++ + K + W Sbjct: 149 LVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETG-YGLKVDIW 202 >5XZW-A nrPDB Length = 471 Score = 57.5 bits (137), Expect = 6e-09, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 51/148 (34%), Gaps = 16/148 (10%) Query: 81 AKLYLIPGLCVPQLIAC---DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 +L ++ L P+++ ++ + E + GG + + + D Sbjct: 243 RELEVLQKLNHPRIVRLKGFYEDTESYYM--VMEFVSGGDLMDFVAAHGAVGE-----DA 295 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---NLVED 194 R++ I +H H DL NI++ +D + DFGL V + ++ Sbjct: 296 GREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP-VLVKITDFGLAKVQGNGSFMKT 354 Query: 195 KGVDLYVLERAILSTHSKHA--EKYNAW 220 L + ++ ++Y Sbjct: 355 FCGTLAYVAPEVIRGKDTSVSPDEYEER 382 >4JXF-A nrPDB Length = 266 Score = 57.5 bits (137), Expect = 6e-09, Method: Composition-based stats. Identities = 32/153 (20%), Positives = 62/153 (40%), Gaps = 19/153 (12%) Query: 78 RLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 R+ ++ + L P ++ + +++L + E G LKN P+ Sbjct: 53 RVQNEVKIHCQLKHPSILELYNYFEDSNYVYL--VLEMCHNGEMNRYLKNR-----VKPF 105 Query: 135 SDLVATT-LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 S+ A + ++ + LH + H DLT SN++L R+ + DFGL + + Sbjct: 106 SENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRN---MNIKIADFGLATQLKMPH 162 Query: 194 DK----GVDLYVLERAILSTHSKHAEKYNAWIM 222 +K + I +T S H + + W + Sbjct: 163 EKHYTLCGTPNYISPEI-ATRSAHGLESDVWSL 194 >3NIZ-A nrPDB Length = 311 Score = 57.5 bits (137), Expect = 6e-09, Method: Composition-based stats. Identities = 37/191 (19%), Positives = 68/191 (35%), Gaps = 24/191 (12%) Query: 35 THPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQL 94 T+ + +AKDS + + R I S + ++ L+ L P + Sbjct: 33 TYGVVYKAKDSQGRIVALKRIRLDAEDEGI-----------PSTAIREISLLKELHHPNI 81 Query: 95 IAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLH 153 ++ D + L + E + +LK L + + L ++ R + H Sbjct: 82 VSLIDVIHSERCLTLVFEFME-----KDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV----SNLVEDKGVDLYVLERAILST 209 + H DL N+++ DGA L DFGL + V L+ +L Sbjct: 137 QHRILHRDLKPQNLLINSDGA---LKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMG 193 Query: 210 HSKHAEKYNAW 220 K++ + W Sbjct: 194 SKKYSTSVDIW 204 >3FI2-A nrPDB Length = 353 Score = 57.5 bits (137), Expect = 6e-09, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 71/207 (34%), Gaps = 29/207 (14%) Query: 18 DIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNES 77 ++ PI GA+ IV A D+ + + + + Q T + Sbjct: 28 NLKPIGSGAQGIVCA---------AYDAVLDRNVAIK-----KLSRPFQNQTHAK----- 68 Query: 78 RLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 R +L L+ + +I+ + + LE + + + D Sbjct: 69 RAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER- 127 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---VSNLVE 193 ++ L ++ I LH H DL SNIV+ D T ++DFGL S ++ Sbjct: 128 -MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD---CTLKILDFGLARTAGTSFMMT 183 Query: 194 DKGVDLYVLERAILSTHSKHAEKYNAW 220 V Y ++ + E + W Sbjct: 184 PYVVTRYYRAPEVILGMG-YKENVDIW 209 >2BPM-A nrPDB Length = 309 Score = 57.1 bits (136), Expect = 8e-09, Method: Composition-based stats. Identities = 35/170 (20%), Positives = 61/170 (35%), Gaps = 25/170 (14%) Query: 67 ALTKHRTLNE-----SRLLAKLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGEDLPGG 116 AL K R E S + ++ L+ L P ++ ++ EFL +DL Sbjct: 36 ALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKF 95 Query: 117 HGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARW 176 S L L+ + L ++ + + H + H DL N+++ +GA Sbjct: 96 MDASALTG--------IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGA-- 145 Query: 177 TPHLIDFGLGSV----SNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 L DFGL + V L+ IL ++ + W + Sbjct: 146 -IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 194 >6QAU-A nrPDB Length = 280 Score = 57.1 bits (136), Expect = 8e-09, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 75/198 (37%), Gaps = 29/198 (14%) Query: 42 AKD--SHQKYIIKYRPPKRYR-HPQIDQALTKHRTLNESRLL--AKLYLIPGLCVPQLIA 96 +D H + + +R R + ++ + L++S++L ++ ++ L ++A Sbjct: 15 KRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVA 74 Query: 97 CD-----PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL 151 P + F+ +E+ GG L+ + + D + L ++ + + Sbjct: 75 LYDVQELPNSVFLVMEYCN----GGDLADYLQAKGTLSE-----DTIRVFLHQIAAAMRI 125 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWT------PHLIDFGLGSV--SNLV-EDKGVDLYVL 202 LH H DL NI+L R + + DFG SN++ D + Sbjct: 126 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYM 185 Query: 203 ERAILSTHSKHAEKYNAW 220 ++ + + K + W Sbjct: 186 APEVIMSQH-YDAKADLW 202 >3MIA-A nrPDB Length = 351 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 48/234 (20%), Positives = 85/234 (36%), Gaps = 50/234 (21%) Query: 5 FIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQI 64 F D+VS Y +A I QG VF R + + QK +K + Sbjct: 12 FCDEVSKY----EKLAKIGQGTFGEVFKA-------RHRKTGQKVALK---------KVL 51 Query: 65 DQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNG-----FIWLEFLGEDLP 114 + + + R + L L+ V LI PYN ++ +F DL Sbjct: 52 MENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA 111 Query: 115 GGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA 174 G SN+ + + + ++ + + +H N H D+ ++N+++ RDG Sbjct: 112 G--LLSNVLVKFTLSE-------IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV 162 Query: 175 RWTPHLIDFGLGSVSNLVE--------DKGVDLYVLERAILSTHSKHAEKYNAW 220 L DFGL +L + ++ V L+ +L + + W Sbjct: 163 ---LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLW 213 >5NGU-A nrPDB Length = 381 Score = 56.3 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 23/150 (15%), Positives = 51/150 (34%), Gaps = 11/150 (7%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 R L ++ ++ +I + +E + + + + Q +D Sbjct: 86 RTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLM-ETDLYKLLKTQHLSNDH 144 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGV 197 + L ++ R + +H + H DL SN++L + DFGL V++ D Sbjct: 145 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT---TCDLKICDFGLARVADPDHDHTG 201 Query: 198 -------DLYVLERAILSTHSKHAEKYNAW 220 + I+ + + + W Sbjct: 202 FLTEYVATRWYRAPEIMLNSKGYTKSIDIW 231 >1KOB-A nrPDB Length = 387 Score = 56.3 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 44/113 (38%), Gaps = 6/113 (5%) Query: 82 KLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVAT 140 ++ ++ L P+LI D + + + E L GG F + D V Sbjct: 98 EISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAA----EDYKMSEAEVIN 153 Query: 141 TLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 +R+ + +H + H D+ NI+ + +IDFGL + N E Sbjct: 154 YMRQACEGLKHMHEHSIVHLDIKPENIMCETK-KASSVKIIDFGLATKLNPDE 205 >3DLS-A nrPDB Length = 335 Score = 56.3 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 77/213 (36%), Gaps = 34/213 (15%) Query: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKR--YRHPQIDQALTKHRTLNE 76 ++P+ GA V+T + K+ K+I K + + P++ + Sbjct: 29 MSPLGSGAFGFVWTAVDKE---KNKEVVVKFIKKEKVLEDCWIEDPKLGK---------- 75 Query: 77 SRLLAKLYLIPGLCVPQLIA-CDPYNGFIWLEFLGEDLPGG-HGFSNLKNFLWMHDQDPY 134 + ++ ++ + +I D + + + + E G F+ + + + Sbjct: 76 --VTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDE---- 129 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 L + R++ +G L D H D+ NIV+ D +T LIDFG S + L Sbjct: 130 -PLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAED---FTIKLIDFG--SAAYLERG 183 Query: 195 KG-----VDLYVLERAILSTHSKHAEKYNAWIM 222 K + +L + + W + Sbjct: 184 KLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSL 216 >3UTO-A nrPDB Length = 573 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 50/119 (42%), Gaps = 7/119 (5%) Query: 68 LTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 +T H + E+ + ++ + L P L+ D + + + E + GG F + + Sbjct: 191 MTPHESDKET-VRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVAD-- 247 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 D +R+V + + +H N+Y H DL NI+ + LIDFGL Sbjct: 248 --EHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSN-ELKLIDFGL 303 >2F9G-A nrPDB Length = 353 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 22/157 (14%), Positives = 53/157 (33%), Gaps = 18/157 (11%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 R L ++ ++ +I E E + + + Q D Sbjct: 55 RTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRV-ISTQMLSDDH 113 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV--------- 188 + + + R + +LH ++ H DL SN+++ + + DFGL + Sbjct: 114 IQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSN---CDLKVCDFGLARIIDESAADNS 170 Query: 189 -----SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + + + ++ T +K++ + W Sbjct: 171 EPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVW 207 >5TQX-A nrPDB Length = 655 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 38/176 (21%), Positives = 61/176 (34%), Gaps = 16/176 (9%) Query: 59 YRHPQIDQALT------KHRTLNESRLLAKLYLIPGLCVPQLIA-CD---PYNGFIW-LE 107 Y+H ++D + + T N R ++ ++ L ++ CD N I + Sbjct: 27 YQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVP 86 Query: 108 FLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNI 167 L + G L N S +++ L +G I LH N H DL NI Sbjct: 87 LLAMEYCSGGDLRKLLNKPENCCGLKESQILS-LLSDIGSGIRYLHENKIIHRDLKPENI 145 Query: 168 VLVRDGARWTPHLIDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 VL G + +ID G L + L L L + + + W Sbjct: 146 VLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE-LFENKPYTATVDYW 200 >3UDB-A nrPDB Length = 317 Score = 55.9 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 49/168 (29%), Gaps = 27/168 (16%) Query: 60 RHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPG 115 R +ID+ + ++ L P ++ + I L + E G Sbjct: 54 RGEKIDENVK-----------REIINHRSLRHPNIVR---FKEVILTPTHLAIVMEYASG 99 Query: 116 GHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR 175 G F + N + D +++ + H H DL N +L A Sbjct: 100 GELFERICNAGRFSE-----DEARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAP 154 Query: 176 WTPHLIDFGLGSVSNLV---EDKGVDLYVLERAILSTHSKHAEKYNAW 220 + DFG S L + + +L + + W Sbjct: 155 -RLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDGKVADVW 201 >2XS0-A nrPDB Length = 386 Score = 55.5 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 71/221 (32%), Gaps = 29/221 (13%) Query: 4 EFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQ 63 E D + L ++ PI GA+ IV I R + + Sbjct: 16 EIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDA--------------ILERNVAIKKLSR 61 Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNL 122 Q T + R +L L+ + +I + + LE + Sbjct: 62 PFQNQTHAK-----RAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDAN 116 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 + + D ++ L ++ I LH H DL SNIV+ D T ++D Sbjct: 117 LCQVIQMELDHER--MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD---CTLKILD 171 Query: 183 FGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 FGL S ++ V Y ++ + E + W Sbjct: 172 FGLARTAGTSFMMVPFVVTRYYRAPEVILGMG-YKENVDIW 211 >4AU8-A nrPDB Length = 296 Score = 55.5 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 63/177 (35%), Gaps = 18/177 (10%) Query: 53 YRPPKRYRHPQIDQALTKHRTLNE---SRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFL 109 ++ R H + + +E S L ++ L+ L ++ + Sbjct: 23 FKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD------VLHS 76 Query: 110 GEDLPGGHGFSNLKNFLWMH--DQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNI 167 + L F + + + D ++V + L ++ + +G H + H DL N+ Sbjct: 77 DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNL 136 Query: 168 VLVRDGARWTPHLIDFGLGSVSNL----VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ++ R+G L DFGL + + V L+ +L ++ + W Sbjct: 137 LINRNGE---LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMW 190 >5DYK-A nrPDB Length = 853 Score = 55.5 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 45/137 (32%), Gaps = 15/137 (10%) Query: 90 CVPQLIAC---DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVG 146 P +I + + + FL E + GG + ++ + L + Sbjct: 597 DHPFIIRLVRTFKDSKYFY--FLTELVTGGELYDAIRKLGLLS-----KSQAQFYLGSII 649 Query: 147 RQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG-SVSNLVEDKGVDLYVLERA 205 I LH + + DL NI+L + G LIDFG V + + Sbjct: 650 LAIEYLHERNIVYRDLKPENILLDKQGY---VKLIDFGCAKKVQGRAYTLVGTPHYMAPE 706 Query: 206 ILSTHSKHAEKYNAWIM 222 ++ + + W + Sbjct: 707 VILGKG-YGCTVDIWAL 722 >1UA2-A nrPDB Length = 346 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 46/221 (20%), Positives = 82/221 (37%), Gaps = 30/221 (13%) Query: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Y R K+++Q IK + +R D +RT L ++ L+ L P +I Sbjct: 27 YKARDKNTNQIVAIK-KIKLGHRSEAKDGI---NRTA-----LREIKLLQELSHPNIIGL 77 Query: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRK----VGRQIGLLH 153 L+ G F ++ L + +D L + ++ + + LH Sbjct: 78 --------LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 Query: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL----GSVSNLVEDKGVDLYVLERAILST 209 + H DL +N++L +G L DFGL GS + + V + +L Sbjct: 130 QHWILHRDLKPNNLLLDENGV---LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Query: 210 HSKHAEKYNAWIMEGF--EEVYREQGAKGAKKLKEVTKRFE 248 + + W + E + R G L ++T+ FE Sbjct: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 >1KOA-A nrPDB Length = 491 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 50/119 (42%), Gaps = 7/119 (5%) Query: 68 LTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 +T H + E+ + ++ + L P L+ D + + + E + GG F + + Sbjct: 85 MTPHESDKET-VRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVAD-- 141 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 D +R+V + + +H N+Y H DL NI+ + LIDFGL Sbjct: 142 --EHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSN-ELKLIDFGL 197 >3ZUT-A nrPDB Length = 362 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 56/189 (29%), Gaps = 31/189 (16%) Query: 39 LPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD 98 L R K S++ +KY + + + HR+L P ++ Sbjct: 37 LMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR---------------HPNIVR-- 79 Query: 99 PYNGFIW----LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHW 154 + I L + E GG F + N + D +++ + H Sbjct: 80 -FKEVILTPTHLAIVMEYASGGELFERICNAGRFSE-----DEARFFFQQLISGVSYCHA 133 Query: 155 NDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV---EDKGVDLYVLERAILSTHS 211 CH DL N +L A + FG S L + + +L Sbjct: 134 MQVCHRDLKLENTLLDGSPAP-RLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKE 192 Query: 212 KHAEKYNAW 220 + + W Sbjct: 193 YDGKVADVW 201 >6CMJ-A nrPDB Length = 321 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 52/156 (33%), Gaps = 30/156 (19%) Query: 82 KLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 ++ ++ L P ++ DP +++ F L N + + Sbjct: 92 EIAILKKLDHPNVVKLVEVLDDPNEDHLYMVF------------ELVNQGPVMEVPTLKP 139 Query: 137 LVATTLR----KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN-- 190 L R + + I LH+ H D+ SN+++ G + DFG+ + Sbjct: 140 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLV---GEDGHIKIADFGVSNEFKGS 196 Query: 191 --LVEDKGVDLYVLERAILSTHSKHA--EKYNAWIM 222 L+ + + LS K + + W M Sbjct: 197 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAM 232 >4UZD-A nrPDB Length = 287 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 41/207 (19%), Positives = 77/207 (37%), Gaps = 34/207 (16%) Query: 21 PISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLL 80 P+ +G V YL R K S K+I+ + Q+++A +H+ L Sbjct: 15 PLGKGKFGNV-------YLAREKQS--KFILALKV---LFKAQLEKAGVEHQ------LR 56 Query: 81 AKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 ++ + L P ++ Y ++L + E P G + L+ +Q Sbjct: 57 REVEIQSHLRHPNILRLYGYFHDATRVYL--ILEYAPLGTVYRELQKLSKFDEQRT---- 110 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG--SVSNLVEDK 195 AT + ++ + H H D+ N++L G+ + DFG + S+ Sbjct: 111 -ATYITELANALSYCHSKRVIHRDIKPENLLL---GSAGELKIADFGWSVHAPSSRRTTL 166 Query: 196 GVDLYVLERAILSTHSKHAEKYNAWIM 222 L L ++ H EK + W + Sbjct: 167 CGTLDYLPPEMIEGR-MHDEKVDLWSL 192 >5EFQ-A nrPDB Length = 347 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 37/179 (20%), Positives = 66/179 (36%), Gaps = 37/179 (20%) Query: 67 ALTKHRTLNESR-----LLAKLYLIPGLCVPQLIACDP-------------YNGFIWL-- 106 AL K R NE + ++ ++ L +I G +L Sbjct: 40 ALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVF 99 Query: 107 EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSN 166 E++ DL G S L +F H + + +R++ + H ++ H D+ SN Sbjct: 100 EYMDHDLMG-LLESGLVHFNENH--------IKSFMRQLMEGLDYCHKKNFLHRDIKCSN 150 Query: 167 IVLVRDGARWTPHLIDFGLGSVSNLVE-----DKGVDLYVLERAILSTHSKHAEKYNAW 220 I+L G L DFGL + + E +K + L+ +L ++ + W Sbjct: 151 ILLNNRGQ---IKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVW 206 >5YV8-A nrPDB Length = 298 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 52/156 (33%), Gaps = 30/156 (19%) Query: 82 KLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 ++ ++ L P ++ DP +++ F L N + + Sbjct: 86 EIAILKKLDHPNVVKLVEVLDDPNEDHLYMVF------------ELVNQGPVMEVPTLKP 133 Query: 137 LVATTLR----KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN-- 190 L R + + I LH+ H D+ SN+++ G + DFG+ + Sbjct: 134 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLV---GEDGHIKIADFGVSNEFKGS 190 Query: 191 --LVEDKGVDLYVLERAILSTHSKHA--EKYNAWIM 222 L+ + + LS K + + W M Sbjct: 191 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAM 226 >5G6V-A nrPDB Length = 324 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 57/150 (38%), Gaps = 21/150 (14%) Query: 80 LAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 + ++ L+ L ++ + + E+L +DL + N + MH+ + Sbjct: 48 IREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLK--QYLDDCGNIINMHNVKLF 105 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV----SN 190 L ++ R + H H DL N+++ G L DFGL + Sbjct: 106 -------LFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE---LKLADFGLARAKSIPTK 155 Query: 191 LVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +++ V L+ IL + ++ + + W Sbjct: 156 TYDNEVVTLWYRPPDILLGSTDYSTQIDMW 185 >4AF3-A nrPDB Length = 292 Score = 54.8 bits (130), Expect = 3e-08, Method: Composition-based stats. Identities = 42/205 (20%), Positives = 73/205 (35%), Gaps = 34/205 (16%) Query: 21 PISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLL 80 P+ +G V YL R K SH +I+ + QI++ +H+ E + Sbjct: 30 PLGKGKFGNV-------YLAREKKSH--FIVALKV---LFKSQIEKEGVEHQLRREIEIQ 77 Query: 81 AKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 A L+ P ++ Y I+L + E P G + L+ +Q Sbjct: 78 AHLH------HPNILRLYNYFYDRRRIYL--ILEYAPRGELYKELQKSCTFDEQRT---- 125 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKG- 196 AT + ++ + H H D+ N + G + + DFG + + K Sbjct: 126 -ATIMEELADALMYCHGKKVIHRDIKPEN---LLLGLKGELKIADFGWSVHAPSLRRKTM 181 Query: 197 -VDLYVLERAILSTHSKHAEKYNAW 220 L L ++ H EK + W Sbjct: 182 CGTLDYLPPEMIEGR-MHNEKVDLW 205 >4NST-A nrPDB Length = 351 Score = 54.4 bits (129), Expect = 5e-08, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 61/177 (34%), Gaps = 33/177 (18%) Query: 67 ALTKHRTLNESR-----LLAKLYLIPGLCVPQLIACDP-------------YNGFIWLEF 108 AL K R NE + ++ ++ L ++ G +L F Sbjct: 42 ALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVF 101 Query: 109 LGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIV 168 + +L L D + + ++++ + H ++ H D+ SNI+ Sbjct: 102 -------EYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNIL 154 Query: 169 LVRDGARWTPHLIDFGLGSVSNLVE-----DKGVDLYVLERAILSTHSKHAEKYNAW 220 L G L DFGL + N E +K + L+ +L ++ + W Sbjct: 155 LNNSGQ---IKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVW 208 >3GC9-A nrPDB Length = 370 Score = 54.4 bits (129), Expect = 5e-08, Method: Composition-based stats. Identities = 25/145 (17%), Positives = 48/145 (33%), Gaps = 6/145 (4%) Query: 78 RLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 R +L L+ L +I D + +E E N + + Q + Sbjct: 73 RTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNI-VKSQALSDE 131 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VSNLVEDK 195 V + ++ R + +H H DL SN+ + D ++DFGL + Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSE---LRILDFGLARQADEEMTGY 188 Query: 196 GVDLYVLERAILSTHSKHAEKYNAW 220 + I+ + + + W Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIW 213 >3HDN-A nrPDB Length = 373 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 60/177 (33%), Gaps = 29/177 (16%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGHGFS 120 +A+ K + + L+ + P L+ + L+++ GG F Sbjct: 74 KAILKKKEEKHIMSERNV-LLKNVKHPFLVGLHFSFQTADKLYFVLDYIN----GGELFY 128 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 +L+ + + +G LH + + DL NI+L G L Sbjct: 129 HLQRERCFLEPRARFYAAE-----IASALGYLHSLNIVYRDLKPENILLDSQG---HIVL 180 Query: 181 IDFGLGSVSNLVEDKGVDLY-----VLERAILSTHSKHAEKYNAWIMEG---FEEVY 229 DFGL N+ + + L +L H + ++ W G +E +Y Sbjct: 181 TDFGLCK-ENIEHNSTTSTFCGTPEYLAPEVL--HKQPYDRTVDWWCLGAVLYEMLY 234 >2UV2-A nrPDB Length = 325 Score = 54.4 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 50/149 (33%), Gaps = 20/149 (13%) Query: 79 LLAKLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 + ++ ++ P ++ N +I +EF GG + + + Sbjct: 81 YMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFC----AGGAVDAVMLELERPLTESQ 136 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 + TL + LH N H DL + NI+ DG L DFG+ + + Sbjct: 137 IQVVCKQTLD----ALNYLHDNKIIHRDLKAGNILFTLDG---DIKLADFGVSAKNTRTI 189 Query: 194 DK----GVDLYVLERAILSTHSKHAEKYN 218 + Y + ++ + Y+ Sbjct: 190 QRRDSFIGTPYWMAPEVVMCETSKDRPYD 218 >1FOT-A nrPDB Length = 318 Score = 54.0 bits (128), Expect = 6e-08, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 74/213 (34%), Gaps = 27/213 (12%) Query: 49 YIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNGF 103 ++I+ R RY ++ + R + ++ + P +I D F Sbjct: 23 HLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIF 82 Query: 104 IWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLT 163 + ++++ GG FS L+ + L + LH D + DL Sbjct: 83 MIMDYI----EGGELFSLLRKSQRFPNPVAKFYAAEVCL-----ALEYLHSKDIIYRDLK 133 Query: 164 SSNIVLVRDGARWTPHLIDFGLGS-VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW-- 220 NI+L ++G + DFG V ++ + ++ST + + + W Sbjct: 134 PENILLDKNG---HIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVST-KPYNKSIDWWSF 189 Query: 221 ------IMEGFEEVYREQGAKGAKKLKEVTKRF 247 ++ G+ Y K +K+ RF Sbjct: 190 GILIYEMLAGYTPFYDSNTMKTYEKILNAELRF 222 >4APC-A nrPDB Length = 350 Score = 54.0 bits (128), Expect = 7e-08, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 68/173 (39%), Gaps = 18/173 (10%) Query: 57 KRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLI---ACDPYNGFIWLEFLGEDL 113 ++Y +I+ + + ESR ++ ++ + P ++ NG +++ + + Sbjct: 50 RQYVIKEINISRMSSKEREESR--REVAVLANMKHPNIVQYRESFEENGSLYI--VMDYC 105 Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 GG F + + Q+ D + ++ + +H H D+ S NI L +DG Sbjct: 106 EGGDLFKRINAQKGVLFQE---DQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDG 162 Query: 174 ARWTPHLIDFGLGSVSN----LVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 T L DFG+ V N L Y L I + + K + W + Sbjct: 163 ---TVQLGDFGIARVLNSTVELARACIGTPYYLSPEI-CENKPYNNKSDIWAL 211 >4BBM-A nrPDB Length = 331 Score = 53.6 bits (127), Expect = 8e-08, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 53/145 (36%), Gaps = 11/145 (7%) Query: 80 LAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 + ++ L+ L L+ +L + +L+ F D +V Sbjct: 72 MREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQ----VVQ 127 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG----LGSVSNLVEDK 195 L ++ IG H ++ H D+ NI++ + G L DFG L + + +D+ Sbjct: 128 KYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGV---VKLCDFGFARTLAAPGEVYDDE 184 Query: 196 GVDLYVLERAILSTHSKHAEKYNAW 220 + +L K+ + + W Sbjct: 185 VATRWYRAPELLVGDVKYGKAVDVW 209 >4AGU-A nrPDB Length = 311 Score = 53.6 bits (127), Expect = 8e-08, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 70/209 (33%), Gaps = 36/209 (17%) Query: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESR 78 I I +G+ +VF R +D+ Q IK D + K L E R Sbjct: 8 IGKIGEGSYGVVFKC-------RNRDTGQIVAIKKFL------ESEDDPVIKKIALREIR 54 Query: 79 LLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 +L L P L+ + L F D H + + H Sbjct: 55 ML------KQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEH------ 102 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV----SNL 191 LV + + + + H ++ H D+ NI++ + L DFG + S+ Sbjct: 103 -LVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSV---IKLCDFGFARLLTGPSDY 158 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +D+ + +L +++ + W Sbjct: 159 YDDEVATRWYRSPELLVGDTQYGPPVDVW 187 >4PDS-A nrPDB Length = 347 Score = 53.6 bits (127), Expect = 9e-08, Method: Composition-based stats. Identities = 22/148 (14%), Positives = 50/148 (33%), Gaps = 16/148 (10%) Query: 81 AKLYLIPGLCVPQLIAC---DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 +L ++ L P+++ ++ + E + GG + + + D Sbjct: 78 RELEVLQKLNHPRIVRLKGFYEDTESYYM--VMEFVSGGDLMDFVAAHGAVGE-----DA 130 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---NLVED 194 R++ I +H H DL NI++ +D + FGL V + ++ Sbjct: 131 GREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP-VLVKITAFGLAKVQGNGSFMKT 189 Query: 195 KGVDLYVLERAILSTHSKHA--EKYNAW 220 L + ++ ++Y Sbjct: 190 FCGTLAYVAPEVIRGKDTSVSPDEYEER 217 >4IC8-A nrPDB Length = 442 Score = 53.2 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 50/155 (32%), Gaps = 12/155 (7%) Query: 75 NESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 N R L +L ++ +IA D + + + + Q Sbjct: 97 NAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPL 156 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV----- 188 + V L ++ R + +H H DL SN+++ + + DFG+ Sbjct: 157 TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCE---LKIGDFGMARGLCTSP 213 Query: 189 ---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + + ++ + ++ + + W Sbjct: 214 AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW 248 >1G3N-A nrPDB Length = 326 Score = 53.2 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 87/253 (34%), Gaps = 42/253 (16%) Query: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESR 78 +A I +GA VF R ++ R Q + T+ E Sbjct: 16 VAEIGEGAYGKVFKARDLKNGGR-------FVALKRVRV-----QTGEEGMPLSTIREVA 63 Query: 79 LLAKLYLIPGLCVPQLIACD----------PYNGFIWLEFLGEDLPGGHGFSNLKNFLWM 128 +L L P ++ + E + +DL + Sbjct: 64 VLRHLET---FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLT--------TYLDKV 112 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 + ++ + + ++ R + LH + H DL NI++ G L DFGL + Sbjct: 113 PEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARI 169 Query: 189 SNL---VEDKGVDLYVLERAILSTHSKHAEKYNAWIMEG-FEEVYREQGA-KGAKKLKEV 243 + + V L+ +L S +A + W + F E++R + +G+ + ++ Sbjct: 170 YSFQMALTSVVVTLWYRAPEVL-LQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQL 228 Query: 244 TKRFEEVRLRGRK 256 K + + L G + Sbjct: 229 GKILDVIGLPGEE 241 >4ZSG-A nrPDB Length = 347 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 21/155 (13%), Positives = 50/155 (32%), Gaps = 12/155 (7%) Query: 75 NESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 N R L +L ++ +IA D + + + + Q Sbjct: 49 NAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPL 108 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV----- 188 + V L ++ R + +H H DL SN+++ + + DFG+ Sbjct: 109 TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCE---LKIGDFGMARGLCTSP 165 Query: 189 ---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + + ++ + ++ + + W Sbjct: 166 AEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW 200 >3QA8-A nrPDB Length = 676 Score = 52.5 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 49/154 (31%), Gaps = 9/154 (5%) Query: 75 NESRLLAKLYLIPGLCVPQLIACDPY-NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 N R ++ ++ L P +++ +G L L +++ + Sbjct: 55 NRERWCLEIQIMKKLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFEN 114 Query: 134 YSDLVATTLRKVGRQIG----LLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-- 187 L +R + I LH N H DL NIVL R +ID G Sbjct: 115 CCGLKEGPIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKEL 174 Query: 188 -VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 L + L L +L K+ + W Sbjct: 175 DQGELCTEFVGTLQYLAPELLE-QKKYTVTVDYW 207 >4KIK-B nrPDB Length = 677 Score = 52.1 bits (123), Expect = 2e-07, Method: Composition-based stats. Identities = 34/169 (20%), Positives = 54/169 (31%), Gaps = 11/169 (6%) Query: 62 PQIDQALTKHRTL--NESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHG 118 QI + N R ++ ++ L P ++A D G L L Sbjct: 45 EQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEY 104 Query: 119 FSNLKNFLWMHDQDPYSDL----VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA 174 +++ + L + T L + + LH N H DL NIVL + Sbjct: 105 CQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQ 164 Query: 175 RWTPHLIDFGLGS---VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 R +ID G +L L L +L K+ + W Sbjct: 165 RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQ-KYTVTVDYW 212 >5FET-A nrPDB Length = 847 Score = 52.1 bits (123), Expect = 2e-07, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 44/135 (32%), Gaps = 11/135 (8%) Query: 90 CVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQ 148 P +I + FL E + GG + ++ + L + L Sbjct: 591 DHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIIL-----A 645 Query: 149 IGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG-SVSNLVEDKGVDLYVLERAIL 207 I LH + + DL NI+L + G LIDFG + + + ++ Sbjct: 646 IEYLHERNIVYRDLKPENILLDKQGY---VKLIDFGCAKKIQGRAYTLVGTPHYMAPEVI 702 Query: 208 STHSKHAEKYNAWIM 222 + + W + Sbjct: 703 LGKG-YGCTVDIWAL 716 >6HXF-B nrPDB Length = 302 Score = 52.1 bits (123), Expect = 2e-07, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 54/147 (36%), Gaps = 16/147 (10%) Query: 79 LLAKLYLIPGLCVPQLIAC---DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 + ++ ++ P ++ ++G +W+ E PGG + + D+ Sbjct: 63 YIVEIEILATCDHPYIVKLLGAYYHDGKLWIMI--EFCPGGAVDAIMLEL----DRGLTE 116 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK 195 + R++ + LH H DL + N+++ +G L DFG+ + + K Sbjct: 117 PQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG---DIRLADFGVSAKNLKTLQK 173 Query: 196 ----GVDLYVLERAILSTHSKHAEKYN 218 Y + ++ + Y+ Sbjct: 174 RDSFIGTPYWMAPEVVMCETMKDTPYD 200 >5WNO-A nrPDB Length = 330 Score = 52.1 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 35/174 (20%), Positives = 64/174 (36%), Gaps = 15/174 (8%) Query: 56 PKRYRHPQIDQALTKHRTLNES--RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDL 113 PKR ++ +I A+ +T +L + + L L+ GF + + + Sbjct: 45 PKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKII---GFCMHDDGLKIV 101 Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 NL+NFL +H ++ + ++ + L H DL + N+++ + Sbjct: 102 TIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKK-- 159 Query: 174 ARWTPHLIDFGLGSVSNLVEDKG------VDLYVLERAILSTH-SKHAEKYNAW 220 + DFGL + D V + L I S H HA A+ Sbjct: 160 -FNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAF 212 >6FDY-U nrPDB Length = 276 Score = 51.7 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 65/183 (35%), Gaps = 21/183 (11%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNES--RLLAKLYLIPGLCVPQLIAC-----DPYNG 102 + K K R + + K S LL ++ ++ G+ P ++ D N Sbjct: 27 VYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNI 86 Query: 103 FIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDL 162 ++ +EF GG + + ++ + ++++ + LH + H DL Sbjct: 87 YLIMEFC----AGGDLSRFIHTRRILPEK-----VARVFMQQLASALQFLHERNISHLDL 137 Query: 163 TSSNIVLVRDGARWTPHLIDFGLGS-VSNLVEDKG--VDLYVLERAILSTHSKHAEKYNA 219 NI+L + L DFG +S E + ++ ++ + + Sbjct: 138 KPQNILL-SSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMV-CQRQYDARVDL 195 Query: 220 WIM 222 W M Sbjct: 196 WSM 198 >2JDO-A nrPDB Length = 342 Score = 51.7 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 61/176 (34%), Gaps = 14/176 (7%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEF 108 +++ + RY +I + + + + ++ P L A + L F Sbjct: 28 LVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCF 87 Query: 109 LGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIV 168 + E GG F +L ++ + + LH D + D+ N++ Sbjct: 88 VMEYANGGELFFHLSRERVFTEERARFYGAE-----IVSALEYLHSRDVVYRDIKLENLM 142 Query: 169 LVRDGARWTPHLIDFGLGS--VSN--LVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 L +DG + DFGL +S+ ++ L +L + + + W Sbjct: 143 LDKDG---HIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWW 194 >4RLP-A nrPDB Length = 288 Score = 51.7 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 56/164 (34%), Gaps = 14/164 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNL 122 + +A+ + + A+ ++ + P ++ + L + E L GG F L Sbjct: 41 LKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQL 100 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 + + D L ++ +G LH + DL NI+L G L D Sbjct: 101 EREGIFME-----DTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG---HVKLTD 152 Query: 183 FGLGSVS----NLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FGL S + + + IL H + W + Sbjct: 153 FGLCKESIHDGTVTHTFCGTIEYMAPEILMRSG-HNRAVDWWSL 195 >2Z7Q-A nrPDB Length = 321 Score = 51.7 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 65/181 (35%), Gaps = 18/181 (9%) Query: 54 RPPKR--YRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLG 110 RP Y + +A K R +++ + + P ++ + L + Sbjct: 52 RPDSGHLYAMKVLKKATLKVRDRVRTKMERDILAD--VNHPFVVKLHYAFQTEGKLYLIL 109 Query: 111 EDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLV 170 + L GG F+ L + ++D L L + LH + DL NI+L Sbjct: 110 DFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL-----GLDHLHSLGIIYRDLKPENILLD 164 Query: 171 RDGARWTPHLIDFGLGSVSNLVEDKG----VDLYVLERAILSTH-SKHAEKYNAWIMEGF 225 +G L DFGL + E K + + +++ H+ + ++ + F Sbjct: 165 EEG---HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMF 221 Query: 226 E 226 E Sbjct: 222 E 222 >1CM8-A nrPDB Length = 367 Score = 51.3 bits (121), Expect = 4e-07, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 70/206 (33%), Gaps = 27/206 (13%) Query: 18 DIAPISQGAEAIVFTTTTHPYLPRA--KDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLN 75 D+ P+ GA V + + K ++ + + + YR ++ + + + Sbjct: 29 DLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVI- 87 Query: 76 ESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 LL L D + ++ + F+G DL M + Sbjct: 88 --GLLDVFTPDETLD-------DFTDFYLVMPFMGTDLG-----------KLMKHEKLGE 127 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VSNLVED 194 D + + ++ + + +H H DL N+ + D ++DFGL + + Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCE---LKILDFGLARQADSEMTG 184 Query: 195 KGVDLYVLERAILSTHSKHAEKYNAW 220 V + ++ ++ + + W Sbjct: 185 YVVTRWYRAPEVILNWMRYTQTVDIW 210 >5D9K-A nrPDB Length = 330 Score = 51.3 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 55/154 (35%), Gaps = 20/154 (12%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 RT E +L ++ P ++ + L + + L GG F+ L + + Sbjct: 78 RTKMERDILVEV------NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE 131 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN 190 +D L L + LH + DL NI+L +G L DFGL S Sbjct: 132 EDVKFYLAELAL-----ALDHLHSLGIIYRDLKPENILLDEEG---HIKLTDFGLSKESI 183 Query: 191 LVEDKG----VDLYVLERAILSTHSKHAEKYNAW 220 E K + + +++ H + + W Sbjct: 184 DHEKKAYSFCGTVEYMAPEVVNRRG-HTQSADWW 216 >4L42-A nrPDB Length = 346 Score = 50.9 bits (120), Expect = 5e-07, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 56/164 (34%), Gaps = 14/164 (8%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFSNL 122 + +A+ + + A+ ++ + P ++ + L + E L GG F L Sbjct: 54 LKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQL 113 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 + + D L ++ +G LH + DL NI+L G L D Sbjct: 114 EREGIFME-----DTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG---HVKLTD 165 Query: 183 FGLGSVS----NLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FGL S + + + IL H + W + Sbjct: 166 FGLCKESIHDGTVTHTFCGTIEYMAPEILMRSG-HNRAVDWWSL 208 >4CRL-A nrPDB Length = 406 Score = 50.9 bits (120), Expect = 5e-07, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 56/157 (35%), Gaps = 20/157 (12%) Query: 81 AKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGHGFSNLK----NFLWMHDQ 131 ++ L+ L P +I+ + +WL F D + +K + Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADRKVWLLF---DYAEHDLWHIIKFHRASKANKKPV 124 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG-ARWTPHLIDFGLGSVSN 190 +V + L ++ I LH N H DL +NI+++ +G R + D G + N Sbjct: 125 QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 184 Query: 191 L-------VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ++ V + +L + + + W Sbjct: 185 SPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW 221 >6FD3-A nrPDB Length = 300 Score = 50.9 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 27/164 (16%), Positives = 59/164 (35%), Gaps = 19/164 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQL---IACDPYNGFIWLEFLGEDLPGGHGFSNL 122 + + + + ++ ++ ++ P + + +W+ + E L GG + Sbjct: 53 KQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWV--VMEYLAGGSLTDVV 110 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 + +A R+ + + LH N H D+ S NI+L G + L D Sbjct: 111 ------TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILL---GMDGSVKLTD 161 Query: 183 FGLGSVSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAWIM 222 FG + + K Y + ++ T + K + W + Sbjct: 162 FGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGPKVDIWSL 204 >3Q53-A nrPDB Length = 306 Score = 50.9 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 58/167 (34%), Gaps = 19/167 (11%) Query: 60 RHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGF 119 R + Q K +NE ++ + + + +W+ + E L GG Sbjct: 52 RQMNLQQQPKKELIINEILVMRE---NKNPNIVNYLDSYLVGDELWV--VMEYLAGGSLT 106 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 + + +A R+ + + LH N H D+ S NI+L G + Sbjct: 107 DVV------TETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILL---GMDGSVK 157 Query: 180 LIDFGLGSVSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAWIM 222 L DFG + + K Y + ++ T + K + W + Sbjct: 158 LTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGPKVDIWSL 203 >5KCV-A nrPDB Length = 460 Score = 50.9 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 56/177 (31%), Gaps = 15/177 (8%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEF 108 ++K + RY +I + + L + ++ P L A + L F Sbjct: 180 LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 239 Query: 109 LGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND-YCHGDLTSSNI 167 + E GG F +L + + + LH + DL N+ Sbjct: 240 VMEYANGGELFFHLSRERVFSEDRARFYGAE-----IVSALDYLHSEKNVVYRDLKLENL 294 Query: 168 VLVRDGARWTPHLIDFGLGSVSNL----VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +L +DG + DFGL ++ L +L + + + W Sbjct: 295 MLDKDG---HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWW 347 >2X4F-A nrPDB Length = 373 Score = 50.9 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 26/152 (17%), Positives = 58/152 (38%), Gaps = 12/152 (7%) Query: 63 QIDQALTKHRTLNESRLLA-KLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPGGHGFS 120 ++ + K R + + + ++ ++ L LI D + + + E + GG F Sbjct: 116 KLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFD 175 Query: 121 NLKNFLW-MHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 + + + + + D ++++ I +H H DL NI+ V A+ Sbjct: 176 RIIDESYNLTELDTIL-----FMKQICEGIRHMHQMYILHLDLKPENILCVNRDAK-QIK 229 Query: 180 LIDFGLG---SVSNLVEDKGVDLYVLERAILS 208 +IDFGL ++ L +++ Sbjct: 230 IIDFGLARRYKPREKLKVNFGTPEFLAPEVVN 261 >3MV5-A nrPDB Length = 342 Score = 50.9 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 56/177 (31%), Gaps = 15/177 (8%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEF 108 ++K + RY +I + + L + ++ P L A + L F Sbjct: 28 LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF 87 Query: 109 LGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND-YCHGDLTSSNI 167 + E GG F +L + + + LH + DL N+ Sbjct: 88 VMEYANGGELFFHLSRERVFSEDRARFYGAE-----IVSALDYLHSEKNVVYRDLKLENL 142 Query: 168 VLVRDGARWTPHLIDFGLGSVSNL----VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +L +DG + DFGL ++ L +L + + + W Sbjct: 143 MLDKDG---HIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN-DYGRAVDWW 195 >5X3F-B nrPDB Length = 393 Score = 50.5 bits (119), Expect = 8e-07, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 54/153 (35%), Gaps = 15/153 (9%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 TLNE R+L + + + D N ++ +E++ GG FS+L+ + Sbjct: 129 EHTLNEKRILQAVNFPFLVKLEFSFK-DNSNLYMVMEYV----AGGEMFSHLRRIGRFSE 183 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VS 189 ++ LH D + DL N+++ + G + DFG V Sbjct: 184 PHARFYAA-----QIVLTFEYLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVK 235 Query: 190 NLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 L I+ + + + + W + Sbjct: 236 GRTWTLCGTPEYLAPEIILSKG-YNKAVDWWAL 267 >2F57-A nrPDB Length = 317 Score = 50.1 bits (118), Expect = 8e-07, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 61/164 (37%), Gaps = 19/164 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW---LEFLGEDLPGGHGFSNL 122 + + + L ++ ++ + D Y+ ++ L + E L GG + Sbjct: 76 KKMDLRKQQRRELLFNEVVIMRDYHHDNV--VDMYSSYLVGDELWVVMEFLEGGALTD-I 132 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M+++ +AT V R + LH H D+ S +I+L DG L D Sbjct: 133 VTHTRMNEEQ-----IATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGR---IKLSD 184 Query: 183 FGL-GSVSNLVEDK---GVDLYVLERAILSTHSKHAEKYNAWIM 222 FG VS V + Y + ++S + + + W + Sbjct: 185 FGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-RLPYGTEVDIWSL 227 >4O2Z-A nrPDB Length = 377 Score = 50.1 bits (118), Expect = 9e-07, Method: Composition-based stats. Identities = 23/150 (15%), Positives = 52/150 (34%), Gaps = 11/150 (7%) Query: 78 RLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 R+L ++ ++ L+ P + F + N + Q Sbjct: 90 RVLREIDMMRFFHHENLLNVVNILPPLKREYHSF-EDVYVVTPLMDVDMNVVLRSRQVLE 148 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL--- 191 + + ++ R + LH + H DL +N+V +IDFGL ++ Sbjct: 149 ESHMQYFVYQILRGLKYLHSANVAHRDLKPANLV---TNISCELKIIDFGLSRSVDVPYS 205 Query: 192 -VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + D + + +L ++ ++ + W Sbjct: 206 ELTDYVITRWYRPPELLLENTNYSTAVDIW 235 >1U5R-A nrPDB Length = 348 Score = 50.1 bits (118), Expect = 9e-07, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 51/158 (32%), Gaps = 15/158 (9%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIA---CDPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 K ++ ++ + L P I C WL + G L Sbjct: 92 KQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVM---EYCLGSASD----LL 144 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +H + +A + + LH ++ H D+ + NI+L G L DFG Sbjct: 145 EVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGL---VKLGDFGSA 201 Query: 187 SVSNLVEDKGVDLYVLERAILST--HSKHAEKYNAWIM 222 S+ Y + ++ ++ K + W + Sbjct: 202 SIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 239 >3DB8-A nrPDB Length = 317 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 30/85 (35%), Gaps = 8/85 (9%) Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV----EDKGV 197 +R+ + + LH N H DL N+ L D + DFGL + +D Sbjct: 148 MRQTIQGVQYLHNNRVIHRDLKLGNLFLNDD---MDVKIGDFGLATKIEFDGERKKDLCG 204 Query: 198 DLYVLERAILSTHSKHAEKYNAWIM 222 + +L E + W + Sbjct: 205 TPNYIAPEVLCKKGHSFE-VDIWSL 228 >5O2B-A nrPDB Length = 285 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 57/161 (35%), Gaps = 18/161 (11%) Query: 69 TKHRTLNESRLLAKLYLIPGLCVPQLIACDP-----YNGFIWLEFLGEDLPGGHGFSNLK 123 K + R + ++ GL P ++ G + + E + G + LK Sbjct: 52 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 111 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWTPHLI 181 F M + ++ + R++ + + LH H DL NI + G + + Sbjct: 112 RFKVMKPK-----VLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFIT--GPTGSVKIG 164 Query: 182 DFGLGSV--SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 D GL ++ ++ + + + H + E + + Sbjct: 165 DLGLATLMRTSFAKSVIGTPEFMAPEMYEEH--YDESVDVY 203 >2OU7-A nrPDB Length = 335 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 29/83 (34%), Gaps = 8/83 (9%) Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK----GV 197 LR++ LH N H DL N+ L D + DFGL + ++ Sbjct: 147 LRQIVLGCQYLHRNRVIHRDLKLGNLFLNED---LEVKIGDFGLATKVEYDGERKKVLCG 203 Query: 198 DLYVLERAILSTHSKHAEKYNAW 220 + +LS E + W Sbjct: 204 TPNYIAPEVLSKKGHSFE-VDVW 225 >4J52-A nrPDB Length = 293 Score = 49.8 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 29/83 (34%), Gaps = 8/83 (9%) Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK----GV 197 LR++ LH N H DL N+ L D + DFGL + ++ Sbjct: 120 LRQIVLGCQYLHRNRVIHRDLKLGNLFLNED---LEVKIGDFGLATKVEYDGERKKVLCG 176 Query: 198 DLYVLERAILSTHSKHAEKYNAW 220 + +LS E + W Sbjct: 177 TPNYIAPEVLSKKGHSFE-VDVW 198 >4QMW-A nrPDB Length = 310 Score = 49.8 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 28/146 (19%), Positives = 54/146 (36%), Gaps = 15/146 (10%) Query: 82 KLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVAT 140 ++ ++ P + Y L + E L GG L+ Q +AT Sbjct: 77 EITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IAT 130 Query: 141 TLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK----G 196 LR++ + + LH H D+ ++N++L G L DFG+ + K Sbjct: 131 ILREILKGLDYLHSEKKIHRDIKAANVLLSEHGE---VKLADFGVAGQLTDTQIKRNTFV 187 Query: 197 VDLYVLERAILSTHSKHAEKYNAWIM 222 + + ++ S + K + W + Sbjct: 188 GTPFWMAPEVIK-QSAYDSKADIWSL 212 >2GCD-A nrPDB Length = 309 Score = 49.8 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 51/158 (32%), Gaps = 15/158 (9%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIA---CDPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 K ++ ++ + L P I C WL + G L Sbjct: 53 KQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVM---EYCLGSASD----LL 105 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 +H + +A + + LH ++ H D+ + NI+L G L DFG Sbjct: 106 EVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGL---VKLGDFGSA 162 Query: 187 SVSNLVEDKGVDLYVLERAILST--HSKHAEKYNAWIM 222 S+ Y + ++ ++ K + W + Sbjct: 163 SIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 200 >5Z33-A nrPDB Length = 425 Score = 49.8 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 20/164 (12%), Positives = 48/164 (29%), Gaps = 17/164 (10%) Query: 65 DQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKN 124 + + R L E +LL + + + F E Sbjct: 69 SKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNF------NETYLYEELMECDLA 122 Query: 125 FLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + Q + + ++ + +H + H DL N+++ A + DFG Sbjct: 123 AIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLV---NADCELKICDFG 179 Query: 185 LGSVSNLVEDK--------GVDLYVLERAILSTHSKHAEKYNAW 220 L ++ ++ + I+ + + + + W Sbjct: 180 LARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVW 223 >3KUL-B nrPDB Length = 325 Score = 49.8 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 33/148 (22%), Positives = 54/148 (36%), Gaps = 7/148 (4%) Query: 52 KYRPPKRYRHPQIDQALTKHRTLNESR-LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLG 110 + R P + P +AL T + R L++ ++ P +I + G + L Sbjct: 69 RLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLE---GVVTRGRLA 125 Query: 111 EDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLV 170 + +L FL HD + LR VG + L Y H DL + N+++ Sbjct: 126 MIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD 185 Query: 171 RDGARWTPHLIDFGLGSVSNLVEDKGVD 198 + + DFGL V D Sbjct: 186 SN---LVCKVSDFGLSRVLEDDPDAAYT 210 >3ZDU-A nrPDB Length = 325 Score = 49.4 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 55/150 (36%), Gaps = 17/150 (11%) Query: 80 LAKLYLIPGLCVPQL---IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 + ++ + L I I L F + L+++ + S Sbjct: 49 MREIKFLKQFHHENLVNLIEVFRQKKKIHLVF---EFIDHTVLDELQHYCHGLE----SK 101 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG----LGSVSNLV 192 + L ++ R I LH N+ H D+ NI++ + G L DFG L + ++ Sbjct: 102 RLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGIT---KLCDFGFARTLAAPGDIY 158 Query: 193 EDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 +D+ + ++ + + + + W + Sbjct: 159 DDEVATRWYRAPELVLKDTSYGKPVDIWAL 188 >6BFN-A nrPDB Length = 342 Score = 49.4 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 34/137 (24%), Positives = 50/137 (36%), Gaps = 11/137 (8%) Query: 59 YRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY---NGFIWLEFLGEDLPG 115 Y ++ + T + L ++ + P ++ Y NGF L + LP Sbjct: 48 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVY--GFLPN 105 Query: 116 GHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDG 173 G L + + L R I LH + HGD+ SSN++L Sbjct: 106 GSLEDRLHCQTQACPPLSWPQRL-DILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDE-- 162 Query: 174 ARWTPHLIDFGLGSVSN 190 R TP L DFGL S Sbjct: 163 -RLTPKLGDFGLARFSR 178 >4WB7-A nrPDB Length = 405 Score = 49.0 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 29/153 (18%), Positives = 55/153 (35%), Gaps = 15/153 (9%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 TLNE R+L + + + D N ++ +E++ PGG FS+L+ + Sbjct: 141 EHTLNEKRILQAVNFPFLVKLEFSFK-DNSNLYMVMEYV----PGGEMFSHLRRIGRFSE 195 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VS 189 ++ LH D + DL N+++ + G + DFG V Sbjct: 196 PHARFYAA-----QIVLTFEYLHSLDLIYRDLKPENLLIDQQGY---IQVTDFGFAKRVK 247 Query: 190 NLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 L I+ + + + + W + Sbjct: 248 GRTWTLCGTPEYLAPEIILSKG-YNKAVDWWAL 279 >5LOH-A nrPDB Length = 341 Score = 49.0 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 37/192 (19%), Positives = 71/192 (36%), Gaps = 31/192 (16%) Query: 2 TQEFIDKVSSYLTPDVD----IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPK 57 T+E +++++ P ++ + PIS+GA V+ L Y Sbjct: 20 TEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKL-------------YAVKV 66 Query: 58 RYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGH 117 + I++ +T L L P + N ++ +E+ L GG Sbjct: 67 VKKADMINKNMTHQVQAERDAL--ALSKSPFIVHLYYSLQSANNVYLVMEY----LIGGD 120 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 S L + + + ++ + +V + LH + H DL N+++ +G Sbjct: 121 VKSLLHIYGYFDE-----EMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEG---H 172 Query: 178 PHLIDFGLGSVS 189 L DFGL V+ Sbjct: 173 IKLTDFGLSKVT 184 >4KS7-A nrPDB Length = 292 Score = 49.0 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 73/191 (38%), Gaps = 27/191 (14%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLK 123 + + + NE ++ V ++ +W+ L E L GG + Sbjct: 58 LRKQQRRELLFNEVVIMRDYQ---HFNVVEMYKSYLVGEELWV--LMEFLQGGALTD-IV 111 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + + ++++ +AT V + + LH H D+ S +I+L DG L DF Sbjct: 112 SQVRLNEEQ-----IATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGR---VKLSDF 163 Query: 184 GLGSVSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYRE 231 G + + K Y + ++S S +A + + W +++G + + Sbjct: 164 GFCAQISKDVPKRKSLVGTPYWMAPEVIS-RSLYATEVDIWSLGIMVIEMVDGEPPYFSD 222 Query: 232 QGAKGAKKLKE 242 + K+L++ Sbjct: 223 SPVQAMKRLRD 233 >5O2C-A nrPDB Length = 380 Score = 49.0 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 57/161 (35%), Gaps = 18/161 (11%) Query: 69 TKHRTLNESRLLAKLYLIPGLCVPQLIACDP-----YNGFIWLEFLGEDLPGGHGFSNLK 123 K + R + ++ GL P ++ G + + E + G + LK Sbjct: 61 RKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK 120 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWTPHLI 181 F M + ++ + R++ + + LH H DL NI + G + + Sbjct: 121 RFKVMKPK-----VLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFIT--GPTGSVKIG 173 Query: 182 DFGLGSV--SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 D GL ++ ++ + + + H + E + + Sbjct: 174 DLGLATLMRTSFAKSVIGTPEFMAPEMYEEH--YDESVDVY 212 >3GC0-A nrPDB Length = 329 Score = 48.6 bits (114), Expect = 2e-06, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 49/150 (32%), Gaps = 17/150 (11%) Query: 80 LAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 + ++ L+ L +I +N + L F N + D Sbjct: 81 IREVSLLKELQHRNIIELKSVIHHNHRLHLIF--------EYAENDLKKYMDKNPDVSMR 132 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP--HLIDFGLGSV----SN 190 ++ + L ++ + H H DL N++L A TP + DFGL Sbjct: 133 VIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIR 192 Query: 191 LVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + L+ IL ++ + W Sbjct: 193 QFTHEIITLWYRPPEILLGSRHYSTSVDIW 222 >3TAC-A nrPDB Length = 361 Score = 48.6 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 19/149 (12%), Positives = 48/149 (32%), Gaps = 11/149 (7%) Query: 79 LLAKLYLIPGLCVPQLIAC---DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 L + + L P ++ +G +++ F E + G + Sbjct: 75 LKREASICHMLKHPHIVELLETYSSDGMLYMVF--EFMDGADLCFEIVKRADAGFV-YSE 131 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG----LGSVSNL 191 + + +R++ + H N+ H D+ ++L L FG LG + Sbjct: 132 AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLV 191 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + + ++ + + + W Sbjct: 192 AGGRVGTPHFMAPEVVKRE-PYGKPVDVW 219 >5D7A-A nrPDB Length = 308 Score = 48.6 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 41/225 (18%), Positives = 80/225 (35%), Gaps = 22/225 (9%) Query: 18 DIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNES 77 D A I + E + T Y R + Q IK +I Q + + + Sbjct: 14 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHH 73 Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 R +A Y P + ++ +EF G G +KN ++ + Sbjct: 74 RNIATYYGAFIKKNPPGMD---DQLWLVMEFCG----AGSVTDLIKNTKGNTLKEEW--- 123 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK-- 195 +A R++ R + LH + H D+ N++L L+DFG+ + + + Sbjct: 124 IAYICREILRGLSHLHQHKVIHRDIKGQNVLL---TENAEVKLVDFGVSAQLDRTVGRRN 180 Query: 196 --GVDLYVLERAILS----THSKHAEKYNAWIMEGFEEVYREQGA 234 Y + +++ + + K + W + G + +GA Sbjct: 181 TFIGTPYWMAPEVIACDENPDATYDFKSDLWSL-GITAIEMAEGA 224 >3PPZ-A nrPDB Length = 309 Score = 48.2 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 51/143 (35%), Gaps = 18/143 (12%) Query: 75 NESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPGGHGFSNLKNFLWMHD 130 + L ++ ++ L P ++ + G + L + E L G + L Sbjct: 77 RVNEFLREVAIMKRLRHPNIV---LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQ 133 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWTPHLIDFGLG-- 186 D L + V + + LH + H DL S N+++ + +T + DFGL Sbjct: 134 LDERRRL--SMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKK---YTVKVCDFGLSRL 188 Query: 187 SVSNLVEDK--GVDLYVLERAIL 207 S + K + +L Sbjct: 189 KASTFLSSKSAAGTPEWMAPEVL 211 >2XIK-A nrPDB Length = 294 Score = 48.2 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 55/148 (37%), Gaps = 19/148 (12%) Query: 82 KLYLIPGLCVPQL---IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 ++ ++ P + + +W+ + E L GG LK + Sbjct: 67 EITVLSQCDSPYITRYFGSYLKSTKLWI--IMEYLGGGSALDLLK------PGPLEETYI 118 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK--- 195 AT LR++ + + LH H D+ ++N++L G L DFG+ + K Sbjct: 119 ATILREILKGLDYLHSERKIHRDIKAANVLLSEQG---DVKLADFGVAGQLTDTQIKRNT 175 Query: 196 -GVDLYVLERAILSTHSKHAEKYNAWIM 222 + + ++ S + K + W + Sbjct: 176 FVGTPFWMAPEVIK-QSAYDFKADIWSL 202 >6CCF-A nrPDB Length = 290 Score = 48.2 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 32/184 (17%), Positives = 59/184 (32%), Gaps = 24/184 (13%) Query: 48 KYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNG 102 +Y RPP R Q Q + L R+ ++ ++ L ++ DP Sbjct: 46 QYGFPRRPPP--RGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAED 103 Query: 103 FIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDL 162 ++L F DL + ++ LR V + LH H D+ Sbjct: 104 NLYLVF---DLLRKGPVMEVPCDKPFSEEQ-----ARLYLRDVILGLEYLHCQKIVHRDI 155 Query: 163 TSSNIVLVRDGARWTPHLIDFGLGSV----SNLVEDKGVDLYVLERAILSTHSKHA--EK 216 SN++L G + DFG+ + + + +S + + Sbjct: 156 KPSNLLL---GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKA 212 Query: 217 YNAW 220 + W Sbjct: 213 LDVW 216 >1S9I-A nrPDB Length = 354 Score = 48.2 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 56/158 (35%), Gaps = 19/158 (12%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPGGHGFSNLKNFLW 127 + ++++ +L ++ P ++ G + + E + GG LK Sbjct: 54 KPAIRNQIIRELQVLHECNSPYIVGFY---GAFYSDGEISICMEHMDGGSLDQVLKEAKR 110 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLL-HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + ++ +A V R + L + H D+ SNI++ G L DFG+ Sbjct: 111 IPEEILGKVSIA-----VLRGLAYLREKHQIMHRDVKPSNILVNSRGE---IKLCDFGVS 162 Query: 187 S--VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + ++ + L ++ + + W M Sbjct: 163 GQLIDSMANSFVGTRSYMAPERLQGTH-YSVQSDIWSM 199 >4E7W-A nrPDB Length = 394 Score = 47.8 bits (112), Expect = 4e-06, Method: Composition-based stats. Identities = 23/150 (15%), Positives = 49/150 (32%), Gaps = 14/150 (9%) Query: 81 AKLYLIPGLCVPQLIACDPY-------NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 +L ++ + P ++ + ++L + E +P Q Sbjct: 81 RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVP--ETVYRASRHYAKLKQTM 138 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 L+ + ++ R + +H CH D+ N++L D LIDFG + E Sbjct: 139 PMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLL--DPPSGVLKLIDFGSAKILIAGE 196 Query: 194 DK---GVDLYVLERAILSTHSKHAEKYNAW 220 Y ++ + + + W Sbjct: 197 PNVSYICSRYYRAPELIFGATNYTTNIDIW 226 >1U59-A nrPDB Length = 287 Score = 47.8 bits (112), Expect = 4e-06, Method: Composition-based stats. Identities = 34/152 (22%), Positives = 56/152 (36%), Gaps = 16/152 (10%) Query: 58 RYRHPQIDQALT--KHRTLNE--SRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDL 113 R R QID A+ K T ++ + ++ L P ++ L + E Sbjct: 32 RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMA 91 Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 GG L ++ P S++ L +V + L ++ H DL + N++LV Sbjct: 92 GGGPLHKFLVGKR---EEIPVSNVAE-LLHQVSMGMKYLEEKNFVHRDLAARNVLLVN-- 145 Query: 174 ARWTPHLIDFGLGSVSNLVEDKGVDLYVLERA 205 R + DFGL D Y R+ Sbjct: 146 -RHYAKISDFGLSKALGAD-----DSYYTARS 171 >4AN9-A nrPDB Length = 301 Score = 47.8 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 56/158 (35%), Gaps = 19/158 (12%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPGGHGFSNLKNFLW 127 + ++++ +L ++ P ++ G + + E + GG LK Sbjct: 47 KPAIRNQIIRELQVLHECNSPYIVGFY---GAFYSDGEISICMEHMDGGSLDQVLKKAGR 103 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLL-HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + +Q +A V + + L + H D+ SNI++ G L DFG+ Sbjct: 104 IPEQILGKVSIA-----VIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVS 155 Query: 187 S--VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + + + + L ++ + + W M Sbjct: 156 GQLIDEMANEFVGTRSYMSPERLQGTH-YSVQSDIWSM 192 >1ZXE-A nrPDB Length = 303 Score = 47.4 bits (111), Expect = 6e-06, Method: Composition-based stats. Identities = 30/205 (14%), Positives = 60/205 (29%), Gaps = 41/205 (20%) Query: 50 IIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFL 109 ++K R R+ I + +H S +L+++ L+ L ++ WLE Sbjct: 22 VVKARNALDSRYYAIKK--IRHTEEKLSTILSEVMLLASLNHQYVVRYYA----AWLERR 75 Query: 110 GEDLPGGHGFSNLKNFLWMH--------------DQDPYSDLVATTLRKVGRQIGLLHWN 155 P F+ M + + D R++ + +H Sbjct: 76 NFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALSYIHSQ 135 Query: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS------------------VSNLVEDKGV 197 H +L NI + + DFGL S+ + Sbjct: 136 GIIHRNLKPMNIFIDESR---NVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIG 192 Query: 198 DLYVLERAILSTHSKHAEKYNAWIM 222 + +L + EK + + + Sbjct: 193 TAMYVATEVLDGTGHYNEKIDMYSL 217 >2I6L-A nrPDB Length = 320 Score = 47.1 bits (110), Expect = 7e-06, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 54/156 (34%), Gaps = 17/156 (10%) Query: 80 LAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMH-------DQD 132 L ++ +I L ++ G + + S +M +Q Sbjct: 56 LREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG 115 Query: 133 PYSDLVATT-LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN- 190 P + A + ++ R + +H + H DL +N+ + + + DFGL + + Sbjct: 116 PLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFI--NTEDLVLKIGDFGLARIMDP 173 Query: 191 ------LVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + + V + +L + + + + + W Sbjct: 174 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMW 209 >5KKR-C nrPDB Length = 395 Score = 47.1 bits (110), Expect = 8e-06, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 56/158 (35%), Gaps = 19/158 (12%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPGGHGFSNLKNFLW 127 + ++++ +L ++ P ++ G + + E + GG LK Sbjct: 106 KPAIRNQIIRELQVLHECNSPYIVGFY---GAFYSDGEISICMEHMDGGSLDQVLKKAGR 162 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLL-HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + +Q +A V + + L + H D+ SNI++ G L DFG+ Sbjct: 163 IPEQILGKVSIA-----VIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVS 214 Query: 187 S--VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + ++ + L ++ + + W M Sbjct: 215 GQLIDSMANSFVGTRSYMSPERLQGTH-YSVQSDIWSM 251 >3N9X-A nrPDB Length = 432 Score = 47.1 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 64/186 (34%), Gaps = 23/186 (12%) Query: 23 SQGAEAIVFTTTTHPYLPRAKDSHQKYIIKY---RPPKRYRHPQIDQALTKHRTLNE--- 76 S G E + F + ++P YIIK+ R Y + D+ K+ + + Sbjct: 8 SSGRENLYFQGIKNVHVPD------NYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR 61 Query: 77 --------SRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWM 128 R+L ++ ++ L +I L E + L+ Sbjct: 62 MFEDLIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFK 121 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 + + T L + +H + H DL +N +L +D + + DFGL Sbjct: 122 TPIFLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQD---CSVKVCDFGLART 178 Query: 189 SNLVED 194 N +D Sbjct: 179 INSEKD 184 >5AIR-A nrPDB Length = 430 Score = 46.7 bits (109), Expect = 9e-06, Method: Composition-based stats. Identities = 23/152 (15%), Positives = 49/152 (32%), Gaps = 18/152 (11%) Query: 81 AKLYLIPGLCVPQLIACDPY-------NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 +L ++ L ++ + ++L + + +P + Q Sbjct: 106 RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTL 163 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 V + ++ R + +H CH D+ N++L D L DFG S LV Sbjct: 164 PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDT--AVLKLCDFG--SAKQLVR 219 Query: 194 DK-----GVDLYVLERAILSTHSKHAEKYNAW 220 + Y ++ + + + W Sbjct: 220 GEPNVSYICSRYYRAPELIFGATDYTSSIDVW 251 >4TPT-A nrPDB Length = 303 Score = 46.7 bits (109), Expect = 9e-06, Method: Composition-based stats. Identities = 29/127 (22%), Positives = 48/127 (37%), Gaps = 15/127 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIA----CDPYNGFIWLEFLGEDLPGGHGFSN 121 + L + + L ++ ++ L P ++ L L E + GG Sbjct: 31 KELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKK---LNLLTEYIEGG----T 83 Query: 122 LKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI 181 LK+FL D P+ V + + + LH H DL S N ++ D T + Sbjct: 84 LKDFLRSMDPFPWQQKV-RFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK---TVVVA 139 Query: 182 DFGLGSV 188 DFGL + Sbjct: 140 DFGLSRL 146 >4BGQ-A nrPDB Length = 304 Score = 46.7 bits (109), Expect = 9e-06, Method: Composition-based stats. Identities = 37/203 (18%), Positives = 72/203 (35%), Gaps = 30/203 (14%) Query: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLA 81 + +GA +V R K++H+ IK +++ + ++ K TL E ++L Sbjct: 20 VGEGAYGVVLKC-------RHKETHEIVAIK-----KFKDSEENE-EVKETTLRELKMLR 66 Query: 82 KLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATT 141 L + +L G ++L F + + N + Y Sbjct: 67 TL---KQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY------- 116 Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG----LGSVSNLVEDKGV 197 + ++ + I H ND H D+ N+++ L DFG L +N D+ V Sbjct: 117 IYQLIKAIHWCHKNDIVHRDIKPENLLI---SHNDVLKLCDFGFARNLSEGNNANYDEEV 173 Query: 198 DLYVLERAILSTHSKHAEKYNAW 220 L + + + + W Sbjct: 174 ATRWYRSPELLLGAPYGKSVDMW 196 >3EQC-A nrPDB Length = 360 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 25/158 (15%), Positives = 56/158 (35%), Gaps = 19/158 (12%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW----LEFLGEDLPGGHGFSNLKNFLW 127 + ++++ +L ++ P ++ G + + E + GG LK Sbjct: 71 KPAIRNQIIRELQVLHECNSPYIVGFY---GAFYSDGEISICMEHMDGGSLDQVLKKAGR 127 Query: 128 MHDQDPYSDLVATTLRKVGRQIGLL-HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + +Q +A V + + L + H D+ SNI++ G L DFG+ Sbjct: 128 IPEQILGKVSIA-----VIKGLTYLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVS 179 Query: 187 S--VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + ++ + L ++ + + W M Sbjct: 180 GQLIDSMANSFVGTRSYMSPERLQGTH-YSVQSDIWSM 216 >4I6B-A nrPDB Length = 308 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 40/205 (19%), Positives = 71/205 (34%), Gaps = 30/205 (14%) Query: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLA 81 + +G A + T L K K I R K ++ +ID+ + HR L+ + + Sbjct: 36 LGKGGFAKCYEMTD---LTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH-KHVV 91 Query: 82 KLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATT 141 + Y D N +I LE+ LK + + + V Sbjct: 92 QFYHYFE---------DKENIYILLEYCSRR----SMAHILKARKVLTEPE-----VRYY 133 Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK----GV 197 LR++ + LH + H DL N + + DFGL + +E + Sbjct: 134 LRQIVSGLKYLHEQEILHRDLKLGNFFI---NESMELKVGDFGLAARLEPLEHRRRTICG 190 Query: 198 DLYVLERAILSTHSKHAEKYNAWIM 222 L +L+ H + + W + Sbjct: 191 TPNYLSPEVLNKQG-HGAESDIWAL 214 >6E2O-A nrPDB Length = 295 Score = 46.3 bits (108), Expect = 1e-05, Method: Composition-based stats. Identities = 29/167 (17%), Positives = 62/167 (37%), Gaps = 11/167 (6%) Query: 63 QIDQALTKHRTLNESRLL-AKLYLIPGLCVPQLIA-CDPYNGFIWLEFLGEDLPGGHGFS 120 +I R S+ L ++ L L ++ ++ +++ E +PGG S Sbjct: 49 RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSL-S 107 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 L W +D + T +++ + LH N H D+ N+++ + + Sbjct: 108 ALLRSKWGPLKDNEQTIGFYT-KQILEGLKYLHDNQIVHRDIKGDNVLI--NTYSGVLKI 164 Query: 181 IDFG----LGSVSNLVEDKGVDLYVLERAILSTHSK-HAEKYNAWIM 222 DFG L ++ E L + I+ + + + + W + Sbjct: 165 SDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSL 211 >5HI2-A nrPDB Length = 283 Score = 46.3 bits (108), Expect = 1e-05, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 37/94 (39%), Gaps = 9/94 (9%) Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 S+L + L + + R+ R + LH H DL S+NI L D T Sbjct: 95 SSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDN---TVK 151 Query: 180 LIDFGLGSV------SNLVEDKGVDLYVLERAIL 207 + DFGL +V S+ E + + ++ Sbjct: 152 IGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 185 >2XNP-A nrPDB Length = 279 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 54/161 (33%), Gaps = 17/161 (10%) Query: 74 LNESRLLAKLYLIPGLCVPQLIACDP---YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 + L++++ L+ L P ++ L + E GG S + Sbjct: 47 AEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLAS-VITKGTKER 105 Query: 131 QDPYSDLVATTLRKVGRQIGLLHW-----NDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 Q + V + ++ + H + H DL +N+ L L DFGL Sbjct: 106 QYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQ---NVKLGDFGL 162 Query: 186 GSVSNLV----EDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + N + Y + ++ S + EK + W + Sbjct: 163 ARILNHDTSFAKTFVGTPYYMSPEQMNRMS-YNEKSDIWSL 202 >4GS6-A nrPDB Length = 315 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 24/174 (13%), Positives = 56/174 (32%), Gaps = 21/174 (12%) Query: 56 PKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFL--G 110 ++R + + + ++ + +L + + P ++ + +E+ G Sbjct: 27 KAKWRAKDVAIKQIESESERKA-FIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGG 85 Query: 111 EDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHW---NDYCHGDLTSSNI 167 HG L + H + + + LH H DL N+ Sbjct: 86 SLYNVLHGAEPLPYYTAAHAMSWCL--------QCSQGVAYLHSMQPKALIHRDLKPPNL 137 Query: 168 VLVRDGARWTPHLIDFGLG-SVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 +LV G + DFG + + + + + S ++EK + + Sbjct: 138 LLVAGGT--VLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEG-SNYSEKCDVF 188 >4C0T-A nrPDB Length = 974 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 51/144 (35%), Gaps = 17/144 (11%) Query: 57 KRYRHPQIDQA-LTKHRTLN----ESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGE 111 K+Y +D+ + K + + E L +L G+ D + + L++ Sbjct: 292 KQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYA-- 349 Query: 112 DLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR 171 G + +K + ++++ ++ I +H N H DL NI+L Sbjct: 350 --SNGELLTLIKRYNTLNEECTRHFGA-----QILDAIKYMHDNGVIHRDLKPENILLDD 402 Query: 172 DGARWTPHLIDFGLGSVSNLVEDK 195 + DFG + D+ Sbjct: 403 KMR---IQITDFGTARLLEKKNDE 423 >5UUU-A nrPDB Length = 547 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 33/190 (17%), Positives = 60/190 (31%), Gaps = 20/190 (10%) Query: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Y R D+ + Y +K K +I + LNE +L+ L+ P ++ Sbjct: 215 YGCRKADTGKMYAMKCLDKK-----RIKMKQGETLALNERIMLS---LVSTGDCPFIVCM 266 Query: 98 -DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND 156 ++ L F+ + + GG +L + D L + +H Sbjct: 267 SYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL-----GLEHMHNRF 321 Query: 157 YCHGDLTSSNIVLVRDGARWTPHLIDFGLGS--VSNLVEDKGVDLYVLERAILSTHSKHA 214 + DL +NI+L G + D GL + +L + Sbjct: 322 VVYRDLKPANILLDEHG---HVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 378 Query: 215 EKYNAWIMEG 224 + W G Sbjct: 379 SSAD-WFSLG 387 >4MYG-A nrPDB Length = 372 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 20/155 (12%), Positives = 52/155 (33%), Gaps = 27/155 (17%) Query: 78 RLLAKLYLIPGLCVPQLIAC-----------DPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 R +L L+ + +I + Y+ ++ + F+ DL Sbjct: 88 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDL------------Q 135 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + + + + + ++ + + +H H DL N+ + D ++DFGL Sbjct: 136 KIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCE---LKILDFGLA 192 Query: 187 S-VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + V + ++ + + + + W Sbjct: 193 RHADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIW 227 >4B6L-A nrPDB Length = 281 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 49/164 (29%), Gaps = 18/164 (10%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNL 122 ++ + + + LNE L L + D N +I+LE Sbjct: 46 RVAKPHQREKILNEIELHRDLQHRHIVRFSHHFE-DADNIYIFLELCSRK---------S 95 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 +W V LR++ + LH H DL N + + D Sbjct: 96 LAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFI---TENMELKVGD 152 Query: 183 FGLGSVSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAWIM 222 FGL + E + + +L H + + W + Sbjct: 153 FGLAARLEPPEQRKKTICGTPNYVAPEVLLRQG-HGPEADVWSL 195 >4Y83-A nrPDB Length = 332 Score = 45.5 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 46/126 (36%), Gaps = 12/126 (9%) Query: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDY 157 + Y +W E + + G G S L+ + + T + V + + LH Sbjct: 129 ELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVT--KHVLKGLDFLHSKKV 186 Query: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV----EDKGVDLYVLERAIL--STHS 211 H D+ SNIV + A L+DFGL +D + ++ HS Sbjct: 187 IHHDIKPSNIVFMSTKAV----LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHS 242 Query: 212 KHAEKY 217 A+ Y Sbjct: 243 TKADIY 248 >5O0Y-A nrPDB Length = 579 Score = 45.5 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 50/141 (35%), Gaps = 10/141 (7%) Query: 63 QIDQALTKHRTLNESRL-LAKLYLIPGLCVPQLIACDPYNGFIWLEF--LGEDLPGGHGF 119 Q+++ + N + + + L P+++ Y F + E G Sbjct: 318 QLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLD 377 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLH--WNDYCHGDLTSSNIVLVRDGARWT 177 LK M +++ S + ++ + L+ H DL NI+LV A Sbjct: 378 FYLKQHKLMSEKEARS-----IIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGE 432 Query: 178 PHLIDFGLGSVSNLVEDKGVD 198 + DFGL + + VD Sbjct: 433 IKITDFGLSKIMDDDSYNSVD 453 >1VZO-A nrPDB Length = 355 Score = 45.5 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 54/166 (32%), Gaps = 17/166 (10%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLK 123 + +A T T E ++L + P L + L+++ GG F++L Sbjct: 96 VQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYIN----GGELFTHLS 151 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + + + L + LH + D+ NI+L +G L DF Sbjct: 152 QRERFTEHEVQIYVGEIVL-----ALEHLHKLGIIYRDIKLENILLDSNG---HVVLTDF 203 Query: 184 GLGSVSNLVE-----DKGVDLYVLERAILSTHSKHAEKYNAWIMEG 224 GL E D + + I+ +K W G Sbjct: 204 GLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLG 249 >3NIE-A nrPDB Length = 429 Score = 45.5 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 40/117 (34%), Gaps = 3/117 (2%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 R+L ++ ++ L +I L E + L+ Sbjct: 73 RILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQH 132 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 V T L + +H + H DL +N +L +D + + DFGL N +D Sbjct: 133 VKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQD---CSVKICDFGLARTINSDKD 186 >3PVW-A nrPDB Length = 695 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 33/190 (17%), Positives = 60/190 (31%), Gaps = 20/190 (10%) Query: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Y R D+ + Y +K K +I + LNE +L+ L+ P ++ Sbjct: 206 YGCRKADTGKMYAMKCLDKK-----RIKMKQGETLALNERIMLS---LVSTGDCPFIVCM 257 Query: 98 -DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND 156 ++ L F+ + + GG +L + D L + +H Sbjct: 258 SYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIIL-----GLEHMHNRF 312 Query: 157 YCHGDLTSSNIVLVRDGARWTPHLIDFGLGS--VSNLVEDKGVDLYVLERAILSTHSKHA 214 + DL +NI+L G + D GL + +L + Sbjct: 313 VVYRDLKPANILLDEHG---HVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYD 369 Query: 215 EKYNAWIMEG 224 + W G Sbjct: 370 SSAD-WFSLG 378 >2H34-A nrPDB Length = 309 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 55/156 (35%), Gaps = 19/156 (12%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMH 129 + R E+R +L + + +G +++ D+ +G Sbjct: 78 RTRMQREARTAGRLQEPHVVP---IHDFGEIDGQLYV-----DMRLINGVDLAAMLRRQG 129 Query: 130 DQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS 189 P + +R++G + H H D+ NI++ A +L+DFG+ S + Sbjct: 130 PLAPPRAVA--IVRQIGSALDAAHAAGATHRDVKPENILV---SADDFAYLVDFGIASAT 184 Query: 190 NLVE-----DKGVDLYVLERAILS-THSKHAEKYNA 219 + + LY + S +H+ + A Sbjct: 185 TDEKLTQLGNTVGTLYYMAPERFSESHATYRADIYA 220 >3EB0-A nrPDB Length = 383 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 24/121 (19%), Positives = 50/121 (41%), Gaps = 11/121 (9%) Query: 105 WLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTS 164 +L + E +P LK+F+ P +L++ + ++ R +G +H CH D+ Sbjct: 112 YLNVIMEYVPD-TLHKVLKSFIRSGRSIPM-NLISIYIYQLFRAVGFIHSLGICHRDIKP 169 Query: 165 SNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLY-----VLERAILSTHSKHAEKYNA 219 N+++ + T L DFG S L+ + Y ++ +++ + Sbjct: 170 QNLLV--NSKDNTLKLCDFG--SAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDL 225 Query: 220 W 220 W Sbjct: 226 W 226 >6BDL-A nrPDB Length = 347 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 24/154 (15%), Positives = 46/154 (29%), Gaps = 13/154 (8%) Query: 73 TLNESRLLAKLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 T + + ++ ++ G ++ + +L L E GG ++ L++ D Sbjct: 76 TRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDS 135 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---V 188 V LH + DL N++L G L+DFG Sbjct: 136 TTRFYTAC-----VVEAFAYLHSKGIIYRDLKPENLILDHRGYA---KLVDFGFAKKIGF 187 Query: 189 SNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + I+ H + W + Sbjct: 188 GKKTWTFCGTPEYVAPEIILNKG-HDISADYWSL 220 >4PWN-A nrPDB Length = 274 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 58/166 (34%), Gaps = 22/166 (13%) Query: 65 DQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGHGF 119 D+ LTK R + ++ GL P ++ G + + E + G Sbjct: 45 DRKLTKSE---RQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLK 101 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWT 177 + LK F M + ++ + R++ + + LH H DL NI + G + Sbjct: 102 TYLKRFKVMKIK-----VLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFIT--GPTGS 154 Query: 178 PHLIDFGLGSVSNL---VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + D GL ++ + + + K+ E + + Sbjct: 155 VKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDESVDVY 198 >4G3E-A nrPDB Length = 352 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 33/174 (18%), Positives = 60/174 (34%), Gaps = 15/174 (8%) Query: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKR-------YRHPQIDQALTKH 71 + P ++ E ++ T P ++ + R + + Q Sbjct: 46 LGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVK 105 Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 + E + +L GL P+++ W+ E L GG +K + + Sbjct: 106 KVRLEVFRVEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPE 165 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 D L + + LH HGD+ + N++L DG+R L DFG Sbjct: 166 -----DRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAA--LCDFG 212 >4FR4-A nrPDB Length = 384 Score = 44.7 bits (104), Expect = 3e-05, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 72/208 (34%), Gaps = 21/208 (10%) Query: 52 KYRPPKRYRHPQIDQALTKHRTLNESR-LLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFL 109 K K Y +++ R NE R + +L ++ GL P L+ + + + Sbjct: 36 KNDTKKMYAMKYMNKQKCVER--NEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMV 93 Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL 169 + L GG +L+ + ++ + + + L H D+ NI+L Sbjct: 94 VDLLLGGDLRYHLQQNVHFKEETVKLFICELVM-----ALDYLQNQRIIHRDMKPDNILL 148 Query: 170 VRDGARWTPHLIDFGLGSV---SNLVEDKGVDLYVLERAILSTH----SKHAEKYNAWIM 222 G H+ DF + ++ + + + S+ A + + + Sbjct: 149 DEHG---HVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGV 205 Query: 223 EGFEEV--YREQGAKGAKKLKEVTKRFE 248 +E + R + + KE+ FE Sbjct: 206 TAYELLRGRRPYHIRSSTSSKEIVHTFE 233 >5F9E-A nrPDB Length = 353 Score = 44.7 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 52/152 (34%), Gaps = 17/152 (11%) Query: 73 TLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 T+ E R+L+ + P L N F +E+L GG ++++ Sbjct: 66 TMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLN----GGDLMYHIQSCHKFDLSR 121 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 L + LH + DL NI+L +DG + DFG+ + L Sbjct: 122 ATFYAAEIIL-----GLQFLHSKGIVYRDLKLDNILLDKDG---HIKIADFGMCKENMLG 173 Query: 193 EDKG----VDLYVLERAILSTHSKHAEKYNAW 220 + K + IL K+ + W Sbjct: 174 DAKTNEFCGTPDYIAPEILLGQ-KYNHSVDWW 204 >4LQP-A nrPDB Length = 508 Score = 44.7 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 46/124 (37%), Gaps = 9/124 (7%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 + + + A+ ++ G P +++ + +L + E LPGG + L + + Sbjct: 142 KKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTE 201 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN 190 + L I +H + H + NI++ R L DFGL + + Sbjct: 202 DVTRFYMAECIL-----AIETIHKLGFIHRAIKPDNILID---IRGHIKLSDFGLSTGFH 253 Query: 191 LVED 194 D Sbjct: 254 KTHD 257 >4QNY-A nrPDB Length = 354 Score = 44.7 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 30/195 (15%), Positives = 72/195 (36%), Gaps = 15/195 (7%) Query: 30 VFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGL 89 + ++ + RA+D+ + KR ++ + R L E +LLA + Sbjct: 27 IIGAGSYGVVIRARDTKSDN--RLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNII 84 Query: 90 CVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI 149 + ++ + F + + + ++LK L Q+ + + + R + Sbjct: 85 GLRNILTPEDPENFDHFYIVMDIME-----TDLKQVLR-SGQELTEAHIQFFIYQALRAL 138 Query: 150 GLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN----LVEDKGVDLYVLERA 205 ++H H D+T +NI++ + + DFGL N + D + Sbjct: 139 HIIHSAGVIHRDITPANILVNTN---CDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195 Query: 206 ILSTHSKHAEKYNAW 220 ++ ++ + + W Sbjct: 196 LVMEDKDYSAQIDVW 210 >5M07-A nrPDB Length = 276 Score = 44.7 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 41/116 (35%), Gaps = 13/116 (11%) Query: 78 RLLAKLYLIPGLCVPQLIACD---PYNGFIW--LEFLGEDLPGGHGFSNLKNFLWMHDQD 132 R + + L P ++ ++G +W ++++ H Sbjct: 76 RFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMAD------RFPAVL 129 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA-RWTPHLIDFGLGS 187 P +++A + V + H H D+ +N+VL A L DFG+ S Sbjct: 130 PVGEVLA-IVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS 184 >5HIE-A nrPDB Length = 302 Score = 44.7 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 31/79 (39%), Gaps = 9/79 (11%) Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV------SNLVE 193 R+ + + LH H DL S+NI L D T + DFGL +V S+ E Sbjct: 131 DIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED---LTVKIGDFGLATVKSRWSGSHQFE 187 Query: 194 DKGVDLYVLERAILSTHSK 212 + + ++ K Sbjct: 188 QLSGSILWMAPEVIRMQDK 206 >6CQF-A nrPDB Length = 297 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 55/160 (34%), Gaps = 23/160 (14%) Query: 74 LNESRLLAKLYLIPGLCVPQLIA-----CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWM 128 + S L ++ ++ ++A +I +EF G G + + Sbjct: 55 DDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCG----AGSLQDIYQVTGSL 110 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 + ++ R+V + + LH H D+ +NI++ G L DFG+ + Sbjct: 111 SELQ-----ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGE---VRLADFGISAQ 162 Query: 189 SNLVEDK----GVDLYVLERAI--LSTHSKHAEKYNAWIM 222 + Y + + ++ + E + W + Sbjct: 163 IGATLARRLAFIGTPYWMAPEVAAVALKGGYNELCDIWSL 202 >5HVK-A nrPDB Length = 315 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 31/177 (17%), Positives = 64/177 (36%), Gaps = 33/177 (18%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIA----CDPYNGFIWLEFLGEDLPGGHGFSN 121 + L + + L ++ ++ L P ++ L F+ E + GG Sbjct: 45 KELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKR---LNFITEYIKGGTLRGI 101 Query: 122 LKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI 181 +K+ M Q P+S V+ + + + LH + H +L S N ++ + + Sbjct: 102 IKS---MDSQYPWSQRVS-FAKDIASGMAYLHSMNIIHRNLNSHNCLVRENK---NVVVA 154 Query: 182 DFGLG--------------SVSNLVEDK----GVDLYVLERAILSTHSKHAEKYNAW 220 DFGL S+ K + Y + +++ S + EK + + Sbjct: 155 DFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRS-YDEKVDVF 210 >5N23-A nrPDB Length = 352 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 56/157 (35%), Gaps = 22/157 (14%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 TLNE R+ + + + D N ++ LE+ PGG FS+L+ + Sbjct: 87 EHTLNEKRIQQAVNFPFLVKLEFSFK-DNSNLYMVLEYA----PGGEMFSHLRRIGRFSE 141 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSN 190 ++ LH D + DL N+++ + G + DFG + Sbjct: 142 PHARFYAA-----QIVLTFEYLHSLDLIYRDLKPENLLIDQQGY---IKVADFGF---AK 190 Query: 191 LVEDKG-----VDLYVLERAILSTHSKHAEKYNAWIM 222 V+ + L I+ + + + + W + Sbjct: 191 RVKGRTPWTLCGTPEYLAPEIILSKG-YNKAVDWWAL 226 >4HZS-A nrPDB Length = 341 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 61/184 (33%), Gaps = 19/184 (10%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 + ++ + L LI ++ + E P G L H + Sbjct: 62 FIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLD----RLRKHQGHFLLGTL 117 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---- 194 + +V +G L + H DL + N++L R + DFGL +D Sbjct: 118 SRYAVQVAEGMGYLESKRFIHRDLAARNLLL---ATRDLVKIGDFGLMRALPQNDDHYVM 174 Query: 195 ---KGVDLYVLERAILSTHS-KHAEKYNAWIMEGFEEVYREQ----GAKGAKKLKEVTKR 246 + V L T + HA + + +E Q G G++ L ++ K Sbjct: 175 QEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE 234 Query: 247 FEEV 250 E + Sbjct: 235 GERL 238 >2WQN-A nrPDB Length = 310 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 25/151 (16%), Positives = 50/151 (33%), Gaps = 16/151 (10%) Query: 80 LAKLYLIPGLCVPQLIACD----PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 + ++ L+ L P +I N L + E G +K+F P Sbjct: 80 IKEIDLLKQLNHPNVIKYYASFIEDNE---LNIVLELADAGDLSRMIKHFKKQKRLIPER 136 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG----SVSNL 191 + + ++ + +H H D+ +N+ + G L D GLG S + Sbjct: 137 TVWKYFV-QLCSALEHMHSRRVMHRDIKPANVFITATGV---VKLGDLGLGRFFSSKTTA 192 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 Y + + + + K + W + Sbjct: 193 AHSLVGTPYYMSPERIHENGYNF-KSDIWSL 222 >1U54-B nrPDB Length = 291 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 61/184 (33%), Gaps = 19/184 (10%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 + ++ + L LI ++ + E P G L H + Sbjct: 68 FIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLD----RLRKHQGHFLLGTL 123 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---- 194 + +V +G L + H DL + N++L R + DFGL +D Sbjct: 124 SRYAVQVAEGMGYLESKRFIHRDLAARNLLL---ATRDLVKIGDFGLMRALPQNDDHYVM 180 Query: 195 ---KGVDLYVLERAILSTHS-KHAEKYNAWIMEGFEEVYREQ----GAKGAKKLKEVTKR 246 + V L T + HA + + +E Q G G++ L ++ K Sbjct: 181 QEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKE 240 Query: 247 FEEV 250 E + Sbjct: 241 GERL 244 >5FQD-C nrPDB Length = 341 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 43/123 (34%), Gaps = 9/123 (7%) Query: 65 DQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKN 124 Q + L ES+L L G+ + + + ++ LG L F+ Sbjct: 53 SQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLE--DLFNFCSR 110 Query: 125 FLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 M +D ++ +I +H ++ H D+ N ++ LIDFG Sbjct: 111 RFTMKTVLMLAD-------QMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFG 163 Query: 185 LGS 187 L Sbjct: 164 LAK 166 >4U41-A nrPDB Length = 332 Score = 44.4 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 34/90 (37%), Gaps = 7/90 (7%) Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 D +A R++ R + LH + H D+ N++L L+DFG+ + + Sbjct: 128 EDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLL---TENAEVKLVDFGVSAQLDRTVG 184 Query: 195 K----GVDLYVLERAILSTHSKHAEKYNAW 220 + Y + +++ Y+ Sbjct: 185 RRNTFIGTPYWMAPEVIACDENPDATYDYR 214 >4AW2-A nrPDB Length = 437 Score = 44.0 bits (102), Expect = 6e-05, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 60/170 (35%), Gaps = 32/170 (18%) Query: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDY 157 D N ++ +++ GG + L F + ++ L ++ I +H Y Sbjct: 145 DDNNLYLVMDY----YVGGDLLTLLSKF----EDRLPEEMARFYLAEMVIAIDSVHQLHY 196 Query: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED-------KGVDLYVLERAILST- 209 H D+ NI++ +G L DFG S L+ED + IL Sbjct: 197 VHRDIKPDNILMDMNG---HIRLADFG--SCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 210 ---HSKHAEKYNAW--------IMEGFEEVYREQGAKGAKKLKEVTKRFE 248 ++ + + W ++ G Y E + K+ +RF+ Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQ 301 >4TNB-A nrPDB Length = 590 Score = 44.0 bits (102), Expect = 7e-05, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 74/202 (36%), Gaps = 17/202 (8%) Query: 57 KRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-DPYNGFIWLEFLGEDLPG 115 K Y ++++ K R ES L + ++ + ++ Y L + + G Sbjct: 210 KMYACKRLEKKRIKKRKG-ESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNG 268 Query: 116 GHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR 175 G ++ N ++ + A ++ + LH + + DL NI+L G Sbjct: 269 GDLKFHIYNMGNPGFEEERALFYAA---EILCGLEDLHHENTVYRDLKPENILLDDYG-- 323 Query: 176 WTPHLIDFGLGSV---SNLVEDKGVDLYVLERAILSTHSKHAEKYNAW-----IMEGFEE 227 + D GL +L+ + + + +L+ ++ + W I E E Sbjct: 324 -HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ-RYGLSPDYWGLGCLIYEMIEG 381 Query: 228 VYREQGAKGAKKLKEVTKRFEE 249 +G K K +EV +R E Sbjct: 382 QSPFRGRKEKVKREEVDRRVLE 403 >4JDH-A nrPDB Length = 346 Score = 44.0 bits (102), Expect = 7e-05, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 61/164 (37%), Gaps = 19/164 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW---LEFLGEDLPGGHGFSNL 122 + + + L ++ ++ + + YN ++ L + E L GG + Sbjct: 105 KKMDLRKQQRRELLFNEVVIMRDYQHENV--VEMYNSYLVGDELWVVMEFLEGGALTD-I 161 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M+++ +A V + + +LH H D+ S +I+L DG L D Sbjct: 162 VTHTRMNEEQ-----IAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR---VKLSD 213 Query: 183 FGL-GSVSNLV---EDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG VS V + Y + ++S + + + W + Sbjct: 214 FGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL 256 >2Q0N-A nrPDB Length = 301 Score = 43.6 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 61/164 (37%), Gaps = 19/164 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW---LEFLGEDLPGGHGFSNL 122 + + + L ++ ++ + + YN ++ L + E L GG + Sbjct: 60 KKMDLRKQQRRELLFNEVVIMRDYQHENV--VEMYNSYLVGDELWVVMEFLEGGALTD-I 116 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M+++ +A V + + +LH H D+ S +I+L DG L D Sbjct: 117 VTHTRMNEEQ-----IAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR---VKLSD 168 Query: 183 FGL-GSVSNLV---EDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG VS V + Y + ++S + + + W + Sbjct: 169 FGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL 211 >4YFF-A nrPDB Length = 311 Score = 43.6 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 32/155 (20%), Positives = 58/155 (37%), Gaps = 24/155 (15%) Query: 79 LLAKLYLIPGLCVPQLIAC------DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 ++ ++ L P +I DP I +++ GG FS L + D Sbjct: 87 FCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYI----SGGSLFSLLHEQKRILDLQ 142 Query: 133 PYSDLVATTLRKVGRQIGLLHW--NDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS-VS 189 + V + + LH H DL S NI+L DG + DFG + Sbjct: 143 SKLIIAVD----VAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAV---VADFGESRFLQ 195 Query: 190 NLVED----KGVDLYVLERAILSTHSKHAEKYNAW 220 +L ED + +L + + + +++ K + + Sbjct: 196 SLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVF 230 >4NEU-A nrPDB Length = 333 Score = 43.6 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 37/110 (33%), Gaps = 21/110 (19%) Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS- 187 + + + ++ + LH H DL NI++ D + + D GL S Sbjct: 115 AEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDND---FHIKIADLGLASF 171 Query: 188 ----------------VSNLVEDKGVDLYVLERAILS-THSKHAEKYNAW 220 V + G LY + L+ ++K EK + + Sbjct: 172 KMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVY 221 >3E3P-A nrPDB Length = 360 Score = 43.6 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 38/189 (20%), Positives = 67/189 (35%), Gaps = 28/189 (14%) Query: 78 RLLAKLYLIPGLCVPQLIACDPY--------NGFIWLEFLGEDLPGGHGFSNLKNFLWMH 129 R L + + L P ++ Y I+L + E +P + Sbjct: 65 RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP--DTLHRCCRNYYRR 122 Query: 130 DQDPYSDLVATTLRKVGRQIGLLH--WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 P L+ L ++ R IG LH + CH D+ N+++ + A T L DFG Sbjct: 123 QVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLV--NEADGTLKLCDFGSAK 180 Query: 188 VSNLVEDKGV---DLYVLERAILSTHSKHAEKYNAW--------IMEGFEEVYREQGAKG 236 + E Y ++ + + + W +M G E ++R G Sbjct: 181 KLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLG-EPIFR--GDNS 237 Query: 237 AKKLKEVTK 245 A +L E+ + Sbjct: 238 AGQLHEIVR 246 >3ORZ-A nrPDB Length = 316 Score = 43.6 bits (101), Expect = 9e-05, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 38/142 (26%), Gaps = 23/142 (16%) Query: 81 AKLYLIPGLCVPQLIAC-----DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 + ++ L P + D + L + G ++ + Sbjct: 86 RERDVMSRLDHPFFVKLYFCFQDDEKLYFGLSYA----KNGELLKYIRKIGSFDETCTRF 141 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK 195 + + LH H DL NI+L D + DFG V + + Sbjct: 142 YTAE-----IVSALEYLHGKGIIHRDLKPENILLNED---MHIQITDFGTAKVLSPESKQ 193 Query: 196 G------VDLYVLERAILSTHS 211 + +L+ S Sbjct: 194 ARANSFVGTAQYVSPELLTEKS 215 >5Y86-A nrPDB Length = 588 Score = 43.6 bits (101), Expect = 9e-05, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 33/85 (38%), Gaps = 3/85 (3%) Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS-NLVEDK 195 LV + + + + LH N H DL NI+L G T +IDFG + Sbjct: 311 LVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCFEYQKLYTY 369 Query: 196 GVDLYVLERAILSTHSKHAEKYNAW 220 + I+ S+++ + W Sbjct: 370 IQSRFYRAPEIILG-SRYSTPIDIW 393 >4TN6-A nrPDB Length = 318 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 24/128 (18%), Positives = 48/128 (37%), Gaps = 15/128 (11%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV-----------SNL 191 ++ +I +H ++ H D+ N ++ ++IDFGL Sbjct: 110 DQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRE 169 Query: 192 VEDKGVDLYVLERAILSTH-SKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEV 250 ++ A ++TH + + G+ +Y G+ + LK TKR + Sbjct: 170 NKNLTGTARY---ASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYE 226 Query: 251 RLRGRKRS 258 R+ +K S Sbjct: 227 RISEKKMS 234 >5TOS-A nrPDB Length = 395 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 30/149 (20%), Positives = 53/149 (35%), Gaps = 26/149 (17%) Query: 79 LLAKLYLIPGLCVPQLIA----CDPYNGFIWL-EFLGEDLPGGHGFSNLKNFL---WMHD 130 L ++ + L P L+ C + + EF+ + H F F W Sbjct: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWN--DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 + D + + LH + + D+ +SNI+L A + L DFGL Sbjct: 178 VNVALDAA--------KGLAFLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLAR- 225 Query: 189 SNLVEDKGVDLYVLERAILSTHSKHAEKY 217 + DL + ++ T+ A +Y Sbjct: 226 ----DGPMGDLSYVSTRVMGTYGYAAPEY 250 >4CSV-A nrPDB Length = 275 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 22/125 (17%), Positives = 44/125 (35%), Gaps = 7/125 (5%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWM 128 K T++ L + ++ L P L+ + + E + G L++ Sbjct: 45 KEGTMSVEEFLQEAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRD---C 101 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 + + +V + L ++ H DL + N ++ G + DFGL + Sbjct: 102 EGHTVNAQALLDMAAQVASGMAYLESQNFIHRDLAARNCLV---GENNVVKVADFGLARL 158 Query: 189 SNLVE 193 N E Sbjct: 159 INEDE 163 >4FIE-A nrPDB Length = 423 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 61/164 (37%), Gaps = 19/164 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW---LEFLGEDLPGGHGFSNL 122 + + + L ++ ++ + + YN ++ L + E L GG + Sbjct: 182 KKMDLRKQQRRELLFNEVVIMRDYQHENV--VEMYNSYLVGDELWVVMEFLEGGALTD-I 238 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M+++ +A V + + +LH H D+ S +I+L DG L D Sbjct: 239 VTHTRMNEEQ-----IAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR---VKLSD 290 Query: 183 FGL-GSVSNLV---EDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG VS V + Y + ++S + + + W + Sbjct: 291 FGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL 333 >3OMV-A nrPDB Length = 307 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 18/74 (24%), Positives = 30/74 (40%), Gaps = 9/74 (12%) Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV------SNLVE 193 R+ + + LH + H D+ S+NI L T + DFGL +V S VE Sbjct: 136 DIARQTAQGMDYLHAKNIIHRDMKSNNIFL---HEGLTVKIGDFGLATVKSRWSGSQQVE 192 Query: 194 DKGVDLYVLERAIL 207 + + ++ Sbjct: 193 QPTGSVLWMAPEVI 206 >4XBR-A nrPDB Length = 366 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 30/164 (18%), Positives = 61/164 (37%), Gaps = 19/164 (11%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW---LEFLGEDLPGGHGFSNL 122 + + + L ++ ++ + + YN ++ L + E L GG + Sbjct: 125 KKMDLRKQQRRELLFNEVVIMRDYQHENV--VEMYNSYLVGDELWVVMEFLEGGALTD-I 181 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 M+++ +A V + + +LH H D+ S +I+L DG L D Sbjct: 182 VTHTRMNEEQ-----IAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR---VKLSD 233 Query: 183 FGL-GSVSNLV---EDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 FG VS V + Y + ++S + + + W + Sbjct: 234 FGFCAQVSKEVPRRKSLVGTPYWMAPELIS-RLPYGPEVDIWSL 276 >4CI6-B nrPDB Length = 643 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 63/180 (35%), Gaps = 26/180 (14%) Query: 71 HRTLNESRLLAKLYLIPGL-----CVPQL-----IACDPYNGFIWLEFLGEDLPGGHGFS 120 R++ E L A+L + P L +A PY + L +++ G Sbjct: 76 ERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDEVDGWRCSD 135 Query: 121 NLKNFLWMHDQ-----DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR 175 L++ Q + Y + ++ L H D+ N+V R Sbjct: 136 TLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGE 195 Query: 176 WTPHLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWI--------MEGFEE 227 P +ID GL S S + KG + + +EK + ++ +EGFE+ Sbjct: 196 --PVVIDLGLHSRSG-EQPKGFTESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEGFEK 252 >4EQM-A nrPDB Length = 294 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 41/122 (33%), Gaps = 15/122 (12%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQL---IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFL 126 K TL R +++ L + I D + +L + E + G +++ Sbjct: 51 KEETLK--RFEREVHNSSQLSHQNIVSMIDVDEEDDCYYL--VMEYIEGPTLSEYIESHG 106 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 + D ++ I H H D+ NI++ + T + DFG+ Sbjct: 107 PLS-----VDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNK---TLKIFDFGIA 158 Query: 187 SV 188 Sbjct: 159 KA 160 >4LG4-A nrPDB Length = 299 Score = 42.8 bits (99), Expect = 1e-04, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 57/136 (41%), Gaps = 16/136 (11%) Query: 79 LLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 ++ ++ ++ P ++ N +W+ + G S++ + ++ Sbjct: 53 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVM---EYCGAGSVSDII---RLRNKTLIE 106 Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL-GSVSNLVED 194 D +AT L+ + + LH+ H ++ + NI+L +G L DFG+ G +++ + Sbjct: 107 DEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEG---HAKLADFGVAGQLTDTMAK 163 Query: 195 K---GVDLYVLERAIL 207 + + + ++ Sbjct: 164 RNTVIGTPFWMAPEVI 179 >3COM-A nrPDB Length = 314 Score = 42.8 bits (99), Expect = 1e-04, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 55/133 (41%), Gaps = 10/133 (7%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 ++ ++ ++ P ++ ++ + G S++ + ++ D + Sbjct: 71 IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDII---RLRNKTLTEDEI 127 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL-GSVSNLVEDK-- 195 AT L+ + + LH+ H D+ + NI+L +G L DFG+ G +++ + + Sbjct: 128 ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEG---HAKLADFGVAGQLTDTMAKRNT 184 Query: 196 -GVDLYVLERAIL 207 + + ++ Sbjct: 185 VIGTPFWMAPEVI 197 >6BXI-A nrPDB Length = 333 Score = 42.8 bits (99), Expect = 1e-04, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 36/94 (38%), Gaps = 8/94 (8%) Query: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDY 157 + + L + E LPGG + L + +++ + T L I +H + Sbjct: 73 YSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVL-----AIDSIHQLGF 127 Query: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL 191 H D+ N++L G L DFGL + Sbjct: 128 IHRDIKPDNLLLDSKG---HVKLSDFGLCTGLKK 158 >2PL0-A nrPDB Length = 289 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 51/134 (38%), Gaps = 9/134 (6%) Query: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFS 120 H ++ K +++ LA+ L+ L +L+ + + E + G Sbjct: 47 HTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVD 106 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 LK + + ++ + + +Y H DL ++NI++ + + Sbjct: 107 FLKTP---SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILV---SDTLSCKI 160 Query: 181 IDFGLGSVSNLVED 194 DFGL + L+ED Sbjct: 161 ADFGL---ARLIED 171 >3SV0-A nrPDB Length = 483 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 48/126 (38%), Gaps = 10/126 (7%) Query: 63 QIDQALTKH-RTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSN 121 +++ TKH + L ES++ L G+ + + + ++ LG L F + Sbjct: 38 KLENVKTKHPQLLYESKIYRILQGGTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCS 97 Query: 122 LKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI 181 K L V ++ ++ +H + H D+ N ++ ++I Sbjct: 98 RKLSLK---------TVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYII 148 Query: 182 DFGLGS 187 DFGL Sbjct: 149 DFGLAK 154 >3PLS-A nrPDB Length = 298 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 36/143 (25%), Positives = 56/143 (39%), Gaps = 22/143 (15%) Query: 59 YRHPQIDQALTKHRTLNES-----------RLLAKLYLIPGLCVPQLIACDPYNGFIWL- 106 Y IDQA + + +S L + L+ GL P ++A I L Sbjct: 38 YHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIG----IMLP 93 Query: 107 -EFLGEDLPGGHGFSNLKNFLWMHDQDPY-SDLVATTLRKVGRQIGLLHWNDYCHGDLTS 164 E L L +L F+ ++P DL++ L +V R + L + H DL + Sbjct: 94 PEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGL-QVARGMEYLAEQKFVHRDLAA 152 Query: 165 SNIVLVRDGARWTPHLIDFGLGS 187 N +L +T + DFGL Sbjct: 153 RNCMLDE---SFTVKVADFGLAR 172 >4HVI-A nrPDB Length = 314 Score = 42.4 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 25/143 (17%), Positives = 48/143 (33%), Gaps = 15/143 (10%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIA---CDPYNGFIWLEFLGEDLPGGHGFSNL 122 + L + ++ ++ L ++ G L + E LP G Sbjct: 45 KQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRD-- 102 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 FL H + + ++ + + L H DL + NI++ + + D Sbjct: 103 --FLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESE---AHVKIAD 157 Query: 183 FGLGSVSNLVEDKGVDLYVLERA 205 FGL + L +D Y + R Sbjct: 158 FGLAKLLPLDKD-----YYVVRE 175 >5L2Q-C nrPDB Length = 320 Score = 42.1 bits (97), Expect = 2e-04, Method: Composition-based stats. Identities = 20/82 (24%), Positives = 35/82 (42%), Gaps = 6/82 (7%) Query: 145 VGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS----VSNLVEDKGVDLY 200 V R + LH + H DL N+VL + R T + +F LG +L++D+ Sbjct: 162 VVRVVEALHQKNIVHRDLKLGNMVLNKRTHRIT--ITNFCLGKHLVSEGDLLKDQRGSPA 219 Query: 201 VLERAILSTHSKHAEKYNAWIM 222 + +LS + + W + Sbjct: 220 YISPDVLSGRPYRGKPSDMWAL 241 >6DBM-A nrPDB Length = 318 Score = 42.1 bits (97), Expect = 2e-04, Method: Composition-based stats. Identities = 28/149 (18%), Positives = 52/149 (34%), Gaps = 20/149 (13%) Query: 82 KLYLIPGLCVPQLIA---CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 ++ ++ L +I C G L+ + E +P G +L H L+ Sbjct: 83 EIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRD----YLPRHSIGLAQLLL 138 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS-------NL 191 +++ + LH Y H DL + N++L D + DFGL + Sbjct: 139 --FAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRL---VKIGDFGLAKAVPEGHEYYRV 193 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ED ++ L + + + W Sbjct: 194 REDGDSPVFWYAPECLKEYKFYYAS-DVW 221 >3C51-A nrPDB Length = 543 Score = 42.1 bits (97), Expect = 2e-04, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 24/68 (35%), Gaps = 7/68 (10%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG----SVSNLVEDKGVDL 199 ++ + LH + + DL N++L DG + D GL + + Sbjct: 297 QIVSGLEHLHQRNIIYRDLKPENVLLDDDG---NVRISDLGLAVELKAGQTKTKGYAGTP 353 Query: 200 YVLERAIL 207 + +L Sbjct: 354 GFMAPELL 361 >5J5T-A nrPDB Length = 370 Score = 42.1 bits (97), Expect = 2e-04, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 57/151 (37%), Gaps = 25/151 (16%) Query: 82 KLYLIPGLCVPQLIA-----CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 ++ ++ P ++A +I +EF G GG H P S+ Sbjct: 51 EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCG----GGSLQD------IYHVTGPLSE 100 Query: 137 L-VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS--VSNLVE 193 L +A R+ + + LH H D+ +NI+L +G L DFG+ + + + + Sbjct: 101 LQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNG---HVKLADFGVSAQITATIAK 157 Query: 194 DKG--VDLYVLERAI--LSTHSKHAEKYNAW 220 K Y + + + + + + W Sbjct: 158 RKAFIGTPYWMAPEVAAVERKGGYNQLCDLW 188 >5J0A-A nrPDB Length = 300 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 26/121 (21%), Positives = 53/121 (43%), Gaps = 11/121 (9%) Query: 72 RTLNESRLLAKLYLIPGLCVPQLIACDPY----NGFIWLEFLGEDLPGGHGFSNLKNFLW 127 R++ + RL+ + ++ L P ++ + +G + L + G ++L + Sbjct: 54 RSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAM---EYGGEKSLNDLIEERY 110 Query: 128 MHDQDPY-SDLVATTLRKVGRQIGLLHW-NDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 QDP+ + ++ + R + LH HGD+ SSN+V+ G T + D G+ Sbjct: 111 KASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVI--KGDFETIKICDVGV 168 Query: 186 G 186 Sbjct: 169 S 169 >4FZF-B nrPDB Length = 283 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 53/146 (36%), Gaps = 15/146 (10%) Query: 82 KLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVAT 140 ++ ++ + Y L + E L GG L+ + Q +AT Sbjct: 56 EITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ------IAT 109 Query: 141 TLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK----G 196 L+++ + + LH H D+ ++N++L G L FG+ + K Sbjct: 110 MLKEILKGLDYLHSEKKIHRDIKAANVLLSEQG---DVKLAAFGVAGQLTDTQIKRNTFV 166 Query: 197 VDLYVLERAILSTHSKHAEKYNAWIM 222 + + ++ S + K + W + Sbjct: 167 GTPFWMAPEVIQ-QSAYDSKADIWSL 191 >5H2U-A nrPDB Length = 267 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 54/162 (33%), Gaps = 16/162 (9%) Query: 66 QALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNF 125 + +++ L++ L +++ + L ++A + + Sbjct: 36 KVISRDNLLHQQMLQSEIQAMKKLRHKHILALYA-----VVSVGDPVYIITELMAKGSLL 90 Query: 126 LWMHDQDPYSDLVATTLR---KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 + D D V+ L +V + L +Y H DL + NI++ G + D Sbjct: 91 ELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILV---GENTLCKVGD 147 Query: 183 FGLGSVSNLV----EDKGVDLYVLERAILSTHSKHAEKYNAW 220 FGL + D + LS ++ K + W Sbjct: 148 FGLARLIKEDVYLSHDHNIPYKWTAPEALS-RGHYSTKSDVW 188 >6AO5-A nrPDB Length = 362 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 19/133 (14%), Positives = 55/133 (41%), Gaps = 10/133 (7%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 ++ ++ ++ P ++ ++ + G S++ + ++ D + Sbjct: 52 IIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDII---RLRNKTLIEDEI 108 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL-GSVSNLVEDK-- 195 AT L+ + + LH+ H ++ + NI+L +G L DFG+ G +++ + + Sbjct: 109 ATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEG---HAKLADFGVAGQLTDTMAKRNT 165 Query: 196 -GVDLYVLERAIL 207 + + ++ Sbjct: 166 VIGTPFWMAPEVI 178 >4RA4-A nrPDB Length = 355 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 23/152 (15%), Positives = 50/152 (32%), Gaps = 17/152 (11%) Query: 73 TLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 T+ E R+LA L P L + +E++ GG +++ + Sbjct: 67 TMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVN----GGDLMYHIQQVGKFKEPQ 122 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 ++ + LH + DL N++L +G + DFG+ + Sbjct: 123 AVFYAAEISI-----GLFFLHKRGIIYRDLKLDNVMLDSEG---HIKIADFGMCKEHMMD 174 Query: 193 ----EDKGVDLYVLERAILSTHSKHAEKYNAW 220 + I++ + + + + W Sbjct: 175 GVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWW 205 >5ZTN-A nrPDB Length = 429 Score = 41.7 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 41/105 (39%), Gaps = 7/105 (6%) Query: 80 LAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 L K + V ++ + I + F +L + + +K + P LV Sbjct: 150 LRKQDKDNTMNVIHMLENFTFRNHICMTF---ELLSMNLYELIKKNKFQGFSLP---LVR 203 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + + + LH N H DL NI+L + G R +IDFG Sbjct: 204 KFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-RSGIKVIDFG 247 >4P5Q-A nrPDB Length = 361 Score = 41.7 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 44/127 (34%), Gaps = 7/127 (5%) Query: 73 TLNESR-LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 T + R L + ++ P +I + G + + +L +FL HD Sbjct: 74 TEKQRRDFLGEASIMGQFDHPNIIRLE---GVVTKSKPVMIVTEYMENGSLDSFLRKHDA 130 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL 191 + LR + + L Y H DL + NI++ + + DFGL V Sbjct: 131 QFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSN---LVCKVSDFGLSRVLED 187 Query: 192 VEDKGVD 198 + Sbjct: 188 DPEAAYT 194 >4M7I-A nrPDB Length = 299 Score = 41.7 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 48/138 (34%), Gaps = 18/138 (13%) Query: 71 HRTLNESRLLAKLYLIPGLCVPQLI-------------ACDPYNGFIWLEFLGEDLPGGH 117 +R L +++ ++ + L P ++ P + ++L ++ L Sbjct: 42 NRELAREKVMREVKALAKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYL-YIQMQLCRKE 100 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 + N ++ + ++ + LH H DL SNI D Sbjct: 101 NLKDWMN-GRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDV--- 156 Query: 178 PHLIDFGLGSVSNLVEDK 195 + DFGL + + E++ Sbjct: 157 VKVGDFGLVTAMDQDEEE 174 >2PMN-X nrPDB Length = 348 Score = 41.7 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 34/90 (37%), Gaps = 7/90 (7%) Query: 137 LVATTLRKVGRQIGLLHWND-YCHGDLTSSNIVLVRDGARWTPHLIDFGLGS--VSNLVE 193 ++ ++ V +H CH D+ SNI++ ++G L DFG V ++ Sbjct: 152 VIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGR---VKLSDFGESEYMVDKKIK 208 Query: 194 DKGVDLYVLERAILSTHSKHA-EKYNAWIM 222 + S S + K + W + Sbjct: 209 GSRGTYEFMPPEFFSNESSYNGAKVDIWSL 238 >6E9W-A nrPDB Length = 443 Score = 41.7 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 46/136 (33%), Gaps = 19/136 (13%) Query: 93 QLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLL 152 QL + ++++ + E +PGG + M + D +V + + Sbjct: 166 QLFYAFQDDRYLYM--VMEYMPGGDLVN------LMSNYDVPEKWARFYTAEVVLALDAI 217 Query: 153 HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV-----EDKGVDLYVLERAIL 207 H + H D+ N++L + G L DFG N + + +L Sbjct: 218 HSMGFIHRDVKPDNMLLDKSG---HLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 208 STHSK---HAEKYNAW 220 + + + + W Sbjct: 275 KSQGGDGYYGRECDWW 290 >1BYG-A nrPDB Length = 278 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 64/167 (38%), Gaps = 15/167 (8%) Query: 59 YRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC----DPYNGFIWLEFLGEDLP 114 YR ++ K+ ++ LA+ ++ L L+ G +++ + E + Sbjct: 42 YRGNKVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYI--VTEYMA 98 Query: 115 GGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA 174 G L++ L+ +L V + L N++ H DL + N+++ D Sbjct: 99 KGSLVDYLRSRGR--SVLGGDCLLKFSLD-VCEAMEYLEGNNFVHRDLAARNVLVSEDNV 155 Query: 175 RWTPHLIDFGLGSVSNLVEDKG-VDLYVLERAILSTHSKHAEKYNAW 220 + DFGL ++ +D G + + L K + K + W Sbjct: 156 A---KVSDFGLTKEASSTQDTGKLPVKWTAPEALR-EKKFSTKSDVW 198 >4XHH-A nrPDB Length = 403 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 51/130 (39%), Gaps = 18/130 (13%) Query: 58 RYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGH 117 R RHPQ+D ESR+ L G+ + + + ++ LG L Sbjct: 43 RSRHPQLDY---------ESRVYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLED-- 91 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + H + + ++ L+ + R + +H + H D+ N ++ T Sbjct: 92 ------LFNYCHRKFSFKTVIMLALQMICR-VQYIHGRSFIHRDIKPDNFLMGVGRRGST 144 Query: 178 PHLIDFGLGS 187 H+IDFGL Sbjct: 145 VHVIDFGLSK 154 >4IDT-A nrPDB Length = 356 Score = 41.7 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 40/104 (38%), Gaps = 8/104 (7%) Query: 82 KLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVAT 140 +L GL P+++ W+ E L GG +K + + D Sbjct: 116 ELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPE-----DRALY 170 Query: 141 TLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 L + + LH HGD+ + N++L DG+ L DFG Sbjct: 171 YLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAA--LCDFG 212 >1K9A-A nrPDB Length = 450 Score = 41.3 bits (95), Expect = 4e-04, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 64/167 (38%), Gaps = 15/167 (8%) Query: 59 YRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC----DPYNGFIWLEFLGEDLP 114 YR ++ K+ ++ LA+ ++ L L+ G +++ + E + Sbjct: 214 YRGNKVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYI--VTEYMA 270 Query: 115 GGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA 174 G L++ L+ +L V + L N++ H DL + N+++ D Sbjct: 271 KGSLVDYLRSRGR--SVLGGDCLLKFSLD-VCEAMEYLEGNNFVHRDLAARNVLVSEDNV 327 Query: 175 RWTPHLIDFGLGSVSNLVEDKG-VDLYVLERAILSTHSKHAEKYNAW 220 + DFGL ++ +D G + + L K + K + W Sbjct: 328 A---KVSDFGLTKEASSTQDTGKLPVKWTAPEALR-EKKFSTKSDVW 370 >5L6P-A nrPDB Length = 298 Score = 41.3 bits (95), Expect = 4e-04, Method: Composition-based stats. Identities = 28/130 (21%), Positives = 49/130 (37%), Gaps = 10/130 (7%) Query: 73 TLNESR-LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 T + R L++ ++ P +I + G + L L +FL ++D Sbjct: 60 TERQRRDFLSEASIMGQFDHPNIIRLE---GVVTKSRPVMILTEFMENCALDSFLRLNDG 116 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL 191 + LR + + L +Y H DL + NI++ + + DFGL S Sbjct: 117 QFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSN---LVCKVSDFGL---SRF 170 Query: 192 VEDKGVDLYV 201 +ED D Sbjct: 171 LEDDPSDPTY 180 >5SYS-A nrPDB Length = 286 Score = 40.9 bits (94), Expect = 5e-04, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 52/132 (39%), Gaps = 9/132 (6%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNL 122 ++ K T++ L + ++ L +L+ + + E + G L Sbjct: 44 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL 103 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 K + + + P + ++ + + +Y H DL ++NI++ G + D Sbjct: 104 KGEMGKYLRLPQ---LVDMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVAD 157 Query: 183 FGLGSVSNLVED 194 FGL + L+ED Sbjct: 158 FGL---ARLIED 166 >4OLI-A nrPDB Length = 645 Score = 40.9 bits (94), Expect = 5e-04, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 52/149 (34%), Gaps = 20/149 (13%) Query: 82 KLYLIPGLCVPQLIA---CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 ++ ++ L +I C G L+ + E +P G +L H L+ Sbjct: 405 EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRD----YLPRHSIGLAQLLL 460 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS-------NL 191 +++ + LH Y H +L + N++L D + DFGL + Sbjct: 461 --FAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRL---VKIGDFGLAKAVPEGHEYYRV 515 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKYNAW 220 ED ++ L + + + W Sbjct: 516 REDGDSPVFWYAPECLKEYKFYYAS-DVW 543 >5UIU-A nrPDB Length = 323 Score = 40.9 bits (94), Expect = 5e-04, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 24/66 (36%), Gaps = 9/66 (13%) Query: 148 QIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK------GVDLYV 201 I LH N + H D+ S+NI+L +T + DFGL S Sbjct: 161 GINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASEKFAQTVMTSRIVGTTAY 217 Query: 202 LERAIL 207 + L Sbjct: 218 MAPEAL 223 >3TKU-A nrPDB Length = 433 Score = 40.9 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 30/170 (17%), Positives = 59/170 (34%), Gaps = 32/170 (18%) Query: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDY 157 D + ++ +++ GG + L F + D+ + ++ I +H Y Sbjct: 161 DENHLYLVMDY----YVGGDLLTLLSKF----EDKLPEDMARFYIGEMVLAIDSIHQLHY 212 Query: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED-------KGVDLYVLERAILST- 209 H D+ N++L +G L DFG S + +D + IL Sbjct: 213 VHRDIKPDNVLLDVNG---HIRLADFG--SCLKMNDDGTVQSSVAVGTPDYISPEILQAM 267 Query: 210 ---HSKHAEKYNAW--------IMEGFEEVYREQGAKGAKKLKEVTKRFE 248 K+ + + W ++ G Y E + K+ +RF+ Sbjct: 268 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQ 317 >6ED6-A nrPDB Length = 415 Score = 40.9 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 46/138 (33%), Gaps = 23/138 (16%) Query: 93 QLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLL 152 QL + ++++ + E +PGG + M + D +V + + Sbjct: 152 QLFYAFQDDRYLYM--VMEYMPGGDLVN------LMSNYDVPEKWAKFYTAEVVLALDAI 203 Query: 153 HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE-------DKGVDLYVLERA 205 H H D+ N++L + G L DFG + + E + Sbjct: 204 HSMGLIHRDVKPDNMLLDKHG---HLKLADFG--TCMKMDETGMVHCDTAVGTPDYISPE 258 Query: 206 ILSTHSK---HAEKYNAW 220 +L + + + + W Sbjct: 259 VLKSQGGDGFYGRECDWW 276 >4XHL-A nrPDB Length = 394 Score = 40.5 bits (93), Expect = 6e-04, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 50/130 (38%), Gaps = 18/130 (13%) Query: 58 RYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGH 117 R RHPQ+D ESR+ L G+ + + + ++ LG L Sbjct: 43 RSRHPQLDY---------ESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLED-- 91 Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT 177 F + H + + ++ L+ R I +H + H D+ N ++ T Sbjct: 92 ------LFNYCHRRFSFKTVIMLALQMFCR-IQYIHGRSFIHRDIKPDNFLMGVGRRGST 144 Query: 178 PHLIDFGLGS 187 H+IDFGL Sbjct: 145 VHVIDFGLSK 154 >2H8H-A nrPDB Length = 535 Score = 40.5 bits (93), Expect = 7e-04, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 51/132 (38%), Gaps = 9/132 (6%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNL 122 ++ K T++ L + ++ L +L+ + + E + G L Sbjct: 293 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL 352 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 K + + P + ++ + + +Y H DL ++NI++ G + D Sbjct: 353 KGETGKYLRLPQ---LVDMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVAD 406 Query: 183 FGLGSVSNLVED 194 FGL + L+ED Sbjct: 407 FGL---ARLIED 415 >3RP9-A nrPDB Length = 458 Score = 40.5 bits (93), Expect = 8e-04, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 41/117 (35%), Gaps = 3/117 (2%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 R+L ++ ++ L ++ +E E + L+ Sbjct: 98 RILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPVYLTELH 157 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 + T L + + +H H DL +N ++ +D + + DFGL + E+ Sbjct: 158 IKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQD---CSVKVCDFGLARTVDYPEN 211 >5TUR-A nrPDB Length = 404 Score = 40.5 bits (93), Expect = 8e-04, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 36/111 (32%), Gaps = 9/111 (8%) Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 P F + + + +L + +V + H H D+ NI++ D Sbjct: 216 PVQDLFDFITERGALQE-----ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI--DL 268 Query: 174 ARWTPHLIDFGLGSVSN--LVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 R LIDFG G++ + D + H H W + Sbjct: 269 NRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSL 319 >3BGP-A nrPDB Length = 333 Score = 40.5 bits (93), Expect = 8e-04, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 36/111 (32%), Gaps = 9/111 (8%) Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 P F + + + +L + +V + H H D+ NI++ D Sbjct: 145 PVQDLFDFITERGALQE-----ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI--DL 197 Query: 174 ARWTPHLIDFGLGSVSN--LVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 R LIDFG G++ + D + H H W + Sbjct: 198 NRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSL 248 >2HK5-A nrPDB Length = 270 Score = 40.5 bits (93), Expect = 8e-04, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 49/129 (37%), Gaps = 6/129 (4%) Query: 60 RHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGF 119 +H ++ K +++ LA+ ++ L +L+ + + E + G Sbjct: 38 KHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLL 97 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 LK+ P + ++ + + +Y H DL ++NI++ A Sbjct: 98 DFLKSDEGSKQPLPK---LIDFSAQIAEGMAFIEQRNYIHRDLRAANILV---SASLVCK 151 Query: 180 LIDFGLGSV 188 + DFGL V Sbjct: 152 IADFGLARV 160 >3SXS-A nrPDB Length = 268 Score = 40.5 bits (93), Expect = 8e-04, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 52/157 (33%), Gaps = 28/157 (17%) Query: 67 ALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGHGFSN 121 + K +++E + + L P+L+ Y +I E++ Sbjct: 38 KMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISN--------GC 89 Query: 122 LKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI 181 L N+L H + + V + L + + H DL + N ++ RD + Sbjct: 90 LLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRD---LCVKVS 146 Query: 182 DFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYN 218 DFG+ YVL+ +S+ Sbjct: 147 DFGM------------TRYVLDDQYVSSVGTKFPVKW 171 >3TXO-A nrPDB Length = 353 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 26/153 (16%), Positives = 45/153 (29%), Gaps = 21/153 (13%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-----PYNGFIWLEFLGEDLPGGHG 118 + + + E + K L P L P F +EF+ GG Sbjct: 56 LKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVN----GGDL 111 Query: 119 FSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP 178 +++ + + + LH + DL N++L +G Sbjct: 112 MFHIQKSRRFDEARARFYAAE-----IISALMFLHDKGIIYRDLKLDNVLLDHEG---HC 163 Query: 179 HLIDFGLGS--VSNLVEDKG--VDLYVLERAIL 207 L DFG+ + N V + IL Sbjct: 164 KLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 >1AD5-A nrPDB Length = 438 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 49/132 (37%), Gaps = 6/132 (4%) Query: 60 RHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGF 119 +H ++ K +++ LA+ ++ L +L+ + + E + G Sbjct: 205 KHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLL 264 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 LK+ P + ++ + + +Y H DL ++NI++ A Sbjct: 265 DFLKSDEGSKQPLPK---LIDFSAQIAEGMAFIEQRNYIHRDLRAANILV---SASLVCK 318 Query: 180 LIDFGLGSVSNL 191 + DFGL V Sbjct: 319 IADFGLARVGAK 330 >5VO2-A nrPDB Length = 300 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 31/82 (37%), Gaps = 13/82 (15%) Query: 145 VGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK------GVD 198 + + LH + H DL S N+++ D + DFG S + DK Sbjct: 109 IAGGMNYLHLHKIIHRDLKSPNMLITYDDV---VKISDFG---TSKELSDKSTKMSFAGT 162 Query: 199 LYVLERAILSTHSKHAEKYNAW 220 + + ++ +EK + W Sbjct: 163 VAWMAPEVIRNEPV-SEKVDIW 183 >5VC6-A nrPDB Length = 289 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 33/162 (20%), Positives = 58/162 (35%), Gaps = 23/162 (14%) Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL 169 E GG + + ++L L +VGR + +H H D+ SNI + Sbjct: 90 NEYCNGGSLADAISENYRIMSYFKEAEL-KDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI 148 Query: 170 VR-----------DGARWTPHLIDFGLGSVSNLV-----EDKGVDLYVLERAILSTHSKH 213 R D W + + F +G + ++ + + D L +L + H Sbjct: 149 SRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTH 208 Query: 214 AEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKRFEEVRLRGR 255 K + F A GA+ L ++ E+R +GR Sbjct: 209 LPKADI-----FALALTVVCAAGAEPLPRNGDQWHEIR-QGR 244 >4RC3-A nrPDB Length = 289 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 21/111 (18%), Positives = 36/111 (32%), Gaps = 9/111 (8%) Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 P F + + + +L + +V + H H D+ NI++ D Sbjct: 101 PVQDLFDFITERGALQE-----ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI--DL 153 Query: 174 ARWTPHLIDFGLGSVSN--LVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 R LIDFG G++ + D + H H W + Sbjct: 154 NRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSL 204 >5CLR-A nrPDB Length = 451 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 37/108 (34%), Gaps = 4/108 (3%) Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 +N + ++ G S KN L ++ + V + V Q+ H H Sbjct: 140 FNEQTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIH 199 Query: 160 GDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKG-VDLYVLERAI 206 DL NI+L A HL+DFG S + L + Sbjct: 200 RDLKPGNIMLD---ADMQCHLVDFGSSSSDKEPKPASWGTASYLAPEL 244 >3QD2-B nrPDB Length = 332 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 35/100 (35%), Gaps = 5/100 (5%) Query: 96 ACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN 155 P + ++L ++ L + N +D + ++ + LH Sbjct: 126 QLQPSSPKVYL-YIQMQLCRKENLKDWMNR-RCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK 195 H DL SNI D + DFGL + + E++ Sbjct: 184 GLMHRDLKPSNIFFTMDDV---VKVGDFGLVTAMDQDEEE 220 >3IO7-A nrPDB Length = 313 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 52/148 (35%), Gaps = 13/148 (8%) Query: 52 KYRPPKRYRHPQIDQALTKHRTLNESR-LLAKLYLIPGLCVPQLIA----CDPYNGFIWL 106 +Y P + + +H T R ++ ++ L ++ C G L Sbjct: 48 RYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYS-AGRRNL 106 Query: 107 EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSN 166 + + E LP G L+ D + ++ + + L Y H DL + N Sbjct: 107 KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTS----QICKGMEYLGTKRYIHRDLATRN 162 Query: 167 IVLVRDGARWTPHLIDFGLGSVSNLVED 194 I++ + + DFGL V ++ Sbjct: 163 ILVENENR---VKIGDFGLTKVLPQDKE 187 >2Y6O-A nrPDB Length = 291 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 47/134 (35%), Gaps = 7/134 (5%) Query: 66 QALTKHRTLNESR-LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKN 124 + L T + R L++ ++ P +I + G + + +L Sbjct: 48 KTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE---GVVTKCKPVMIITEYMENGSLDA 104 Query: 125 FLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 FL +D + LR +G + L Y H DL + NI++ + + DFG Sbjct: 105 FLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSN---LVCKVSDFG 161 Query: 185 LGSVSNLVEDKGVD 198 + V + Sbjct: 162 MSRVLEDDPEAAYT 175 >2CMW-A nrPDB Length = 310 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 22/46 (47%), Gaps = 2/46 (4%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDG--ARWTPHLIDFGLGS 187 ++ ++ +H + + D+ N ++ R G H+IDFGL Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAK 150 >2VD5-A nrPDB Length = 412 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 27/110 (24%), Positives = 39/110 (35%), Gaps = 16/110 (14%) Query: 105 WLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTS 164 +L + E GG + L F + +A + + +H Y H D+ Sbjct: 135 YLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDS----VHRLGYVHRDIKP 190 Query: 165 SNIVLVRDGARWTPHLIDFGL-------GSVSNLVEDKGVDLYVLERAIL 207 NI+L R G L DFG G+V +LV L IL Sbjct: 191 DNILLDRCG---HIRLADFGSCLKLRADGTVRSLV--AVGTPDYLSPEIL 235 >5AR8-A nrPDB Length = 326 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 48/144 (33%), Gaps = 13/144 (9%) Query: 46 HQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIW 105 H + ++ + H + + K L E+ +L K L + + + Sbjct: 53 HADWRVQVAVKHLHIHTPLLDSERKD-VLREAEILHKARFSYILPILGICNEPEF----- 106 Query: 106 LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWND--YCHGDLT 163 L + E +P G L D L ++ + LH H DL Sbjct: 107 LGIVTEYMPNGSLNELLHRKTEYPDVAWPLRF--RILHEIALGVNYLHNMTPPLLHHDLK 164 Query: 164 SSNIVLVRDGARWTPHLIDFGLGS 187 + NI+L + + + DFGL Sbjct: 165 TQNILLDNE---FHVKIADFGLSK 185 >2W1I-A nrPDB Length = 326 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 52/148 (35%), Gaps = 13/148 (8%) Query: 52 KYRPPKRYRHPQIDQALTKHRTLNESR-LLAKLYLIPGLCVPQLIA----CDPYNGFIWL 106 +Y P + + +H T R ++ ++ L ++ C G L Sbjct: 61 RYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYS-AGRRNL 119 Query: 107 EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSN 166 + + E LP G L+ D + ++ + + L Y H DL + N Sbjct: 120 KLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTS----QICKGMEYLGTKRYIHRDLATRN 175 Query: 167 IVLVRDGARWTPHLIDFGLGSVSNLVED 194 I++ + + DFGL V ++ Sbjct: 176 ILVENENR---VKIGDFGLTKVLPQDKE 200 >4YHJ-A nrPDB Length = 584 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 39/111 (35%), Gaps = 13/111 (11%) Query: 148 QIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS---VSNLVEDKGVDLYVLER 204 + L + DL NI+L G + D GL + V + + + Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDRG---HIRISDLGLATEIPEGQRVRGRVGTVGYMAP 355 Query: 205 AILSTHSKHAEKYNAWIMEG--FEEVYREQGAKGAKKLKEVTKRFEEVRLR 253 +++ W + +E + QG KK KE K +EEV R Sbjct: 356 EVVNNEKYTFSPDW-WGLGCLIYEMI---QGHSPFKKYKEKVK-WEEVDQR 401 >2VWV-A nrPDB Length = 302 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 43/116 (37%), Gaps = 7/116 (6%) Query: 73 TLNESR-LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 T + R L++ ++ P +I + G + L L +FL ++D Sbjct: 57 TERQRREFLSEASIMGQFEHPNIIRLE---GVVTNSMPVMILTEFMENGALDSFLRLNDG 113 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + LR + + L Y H DL + NI++ + + DFGL Sbjct: 114 QFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSN---LVCKVSDFGLSR 166 >6F3F-A nrPDB Length = 455 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 51/132 (38%), Gaps = 9/132 (6%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNL 122 ++ K T++ L + ++ L +L+ + + E + G L Sbjct: 213 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFL 272 Query: 123 KNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLID 182 K + + P + ++ + + +Y H DL ++NI++ G + D Sbjct: 273 KGETGKYLRLPQ---LVDMSAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVAD 326 Query: 183 FGLGSVSNLVED 194 FGL + L+ED Sbjct: 327 FGL---ARLIED 335 >6B2Q-A nrPDB Length = 317 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 58/183 (31%), Gaps = 18/183 (9%) Query: 78 RLLAKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 R A+ L P + + Y NG +L +L G +++ Sbjct: 78 RFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLR 137 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 D+ L + GR + + H H D+ NI++ G + DFG+ + Sbjct: 138 HALDM----LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQ---VKITDFGIAKAVDAA 190 Query: 193 EDK-----GVDLYVLERAILSTH-SKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKR 246 + H + A + + G+E V ++ G L K Sbjct: 191 PVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKH 250 Query: 247 FEE 249 +E Sbjct: 251 IKE 253 >4X3F-A nrPDB Length = 337 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 58/183 (31%), Gaps = 18/183 (9%) Query: 78 RLLAKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 R A+ L P + + Y NG +L +L G +++ Sbjct: 58 RFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLR 117 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 D+ L + GR + + H H D+ NI++ G + DFG+ + Sbjct: 118 HALDM----LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQ---VKITDFGIAKAVDAA 170 Query: 193 EDK-----GVDLYVLERAILSTH-SKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKR 246 + H + A + + G+E V ++ G L K Sbjct: 171 PVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKH 230 Query: 247 FEE 249 +E Sbjct: 231 IKE 233 >4OW8-A nrPDB Length = 283 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 58/183 (31%), Gaps = 18/183 (9%) Query: 78 RLLAKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 R A+ L P + + Y NG +L +L G +++ Sbjct: 57 RFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLR 116 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 D+ L + GR + + H H D+ NI++ G + DFG+ + Sbjct: 117 HALDM----LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQ---VKITDFGIAKAVDAA 169 Query: 193 EDK-----GVDLYVLERAILSTH-SKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVTKR 246 + H + A + + G+E V ++ G L K Sbjct: 170 PVTQTGMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKH 229 Query: 247 FEE 249 +E Sbjct: 230 IKE 232 >4X7Q-B nrPDB Length = 312 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 21/81 (25%), Positives = 29/81 (35%), Gaps = 4/81 (4%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV--SNLVEDKGVDLYV 201 +V I H H D+ NI++ D R LIDFG G++ D Sbjct: 147 QVVAAIQHCHSRGVVHRDIKDENILI--DLRRGCAKLIDFGSGALLHDEPYTDFDGTRVY 204 Query: 202 LERAILSTHSKHAEKYNAWIM 222 +S H HA W + Sbjct: 205 SPPEWISRHQYHALPATVWSL 225 >5UNP-A nrPDB Length = 369 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 52/152 (34%), Gaps = 27/152 (17%) Query: 87 PGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLR-KV 145 LCV Q+ Y+G + + F +L G F LK+ ++ PY + ++ Sbjct: 96 KNLCV-QMFDWFDYHGHMCISF---ELLGLSTFDFLKDNNYL----PYPIHQVRHMAFQL 147 Query: 146 GRQIGLLHWNDYCHGDLTSSNIVL----------------VRDGARWTPHLIDFGLGSVS 189 + + LH N H DL NI+ R ++DFG + Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFD 207 Query: 190 NLVEDKGV-DLYVLERAILSTHSKHAEKYNAW 220 + V + ++ ++ + W Sbjct: 208 HEHHSTIVSTRHYRAPEVILELG-WSQPCDVW 238 >5UU1-A nrPDB Length = 324 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 49/147 (33%), Gaps = 21/147 (14%) Query: 54 RPPKRYRH----------PQIDQALTKHRTLNE---SRLLAKLYLIP-GLCVPQLIACDP 99 +P K RH P + R + + + + L G+ + Sbjct: 40 KPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTE 99 Query: 100 YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCH 159 + G + + E L G + + L L + +H N+Y H Sbjct: 100 FKGRSYRFMVMERL--GIDLQKISGQNGTFKKSTVLQLGIRMLD----VLEYIHENEYVH 153 Query: 160 GDLTSSNIVLVRDGARWTPHLIDFGLG 186 GD+ ++N++L +L D+GL Sbjct: 154 GDIKAANLLLGYKNPD-QVYLADYGLS 179 >3UIU-A nrPDB Length = 306 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 33/91 (36%), Gaps = 7/91 (7%) Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 L ++ + + +H H DL SNI LV + DFGL + Sbjct: 135 KVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ---VKIGDFGLVTSLKNDGK 191 Query: 195 KG---VDLYVLERAILSTHSKHAEKYNAWIM 222 + L + +S+ + ++ + + + Sbjct: 192 RTRSKGTLRYMSPEQISSQ-DYGKEVDLYAL 221 >2RIO-A nrPDB Length = 434 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 16/110 (14%), Positives = 33/110 (30%), Gaps = 12/110 (10%) Query: 90 CVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATT--LRKVGR 147 P +I ++ +L + +++ + LR++ Sbjct: 67 DHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 148 QIGLLHWNDYCHGDLTSSNIVL--------VRDGARWTPHLI--DFGLGS 187 + LH H DL NI++ + ++ DFGL Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCK 176 >4UY9-A nrPDB Length = 323 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 60/181 (33%), Gaps = 32/181 (17%) Query: 55 PPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNGFIWLEFL 109 P D + T E++L A L P +IA N + +EF Sbjct: 37 VKAARHDPDEDISQTIENVRQEAKLFAMLK------HPNIIALRGVCLKEPNLCLVMEF- 89 Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN---DYCHGDLTSSN 166 G + + + + D++ ++ R + LH H DL SSN Sbjct: 90 ----ARGGPLNRVLSGKRI-----PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSN 140 Query: 167 IVLVR-----DGARWTPHLIDFGLGSVSNLVE--DKGVDLYVLERAILSTHSKHAEKYNA 219 I++++ D + + DFGL + + ++ S ++ + Sbjct: 141 ILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRA-SMFSKGSDV 199 Query: 220 W 220 W Sbjct: 200 W 200 >6J5U-C nrPDB Length = 426 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 29/146 (19%), Positives = 50/146 (34%), Gaps = 22/146 (15%) Query: 79 LLAKLYLIPGLCVPQLIACDPY-----NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 L ++ + L P L+ Y N + EF+ + H F L + Sbjct: 137 WLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMK 196 Query: 134 YSDLVATTLRKVGRQIGLLH--WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL 191 + A + + LH + + D ++NI+L A + L DFGL Sbjct: 197 VAVGAA-------KGLTFLHEAKSQVIYRDFKAANILLD---ADFNAKLSDFGLAKAG-- 244 Query: 192 VEDKGVDLYVLERAILSTHSKHAEKY 217 D + ++ TH A +Y Sbjct: 245 ---PTGDNTHVSTKVIGTHGYAAPEY 267 >6FYV-A nrPDB Length = 337 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 31/102 (30%), Gaps = 18/102 (17%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL----------------VRDGARWTPH 179 D + ++ + I LH N H DL NI+ R Sbjct: 118 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 177 Query: 180 LIDFGLGSVSNLVEDKGV-DLYVLERAILSTHSKHAEKYNAW 220 ++DFG + + V + ++ ++ + W Sbjct: 178 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALG-WSQPCDVW 218 >1JPA-A nrPDB Length = 312 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 36/188 (19%), Positives = 63/188 (33%), Gaps = 26/188 (13%) Query: 16 DVDIAPISQ--GAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRT 73 D+ I Q GA + H LP ++ ++ Y K R Sbjct: 31 DISCVKIEQVIGAGEFGEVCSGHLKLPGKREI---FVAIKTLKSGYTE--------KQRR 79 Query: 74 LNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 L++ ++ P +I + G + + +L +FL +D Sbjct: 80 D----FLSEASIMGQFDHPNVIHLE---GVVTKSTPVMIITEFMENGSLDSFLRQNDGQF 132 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 + LR + + L +Y H DL + NI++ + + DFGL S +E Sbjct: 133 TVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSN---LVCKVSDFGL---SRFLE 186 Query: 194 DKGVDLYV 201 D D Sbjct: 187 DDTSDPTY 194 >2DQ7-X nrPDB Length = 283 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 49/130 (37%), Gaps = 9/130 (6%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMH 129 K T++ L + ++ L +L+ + + E + G LK+ Sbjct: 42 KPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRA 101 Query: 130 DQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS 189 + P + +V + + +Y H DL S+NI++ G + DFGL + Sbjct: 102 LKLPN---LVDMAAQVAAGMAYIERMNYIHRDLRSANILV---GNGLICKIADFGL---A 152 Query: 190 NLVEDKGVDL 199 L+ED Sbjct: 153 RLIEDNEYTA 162 >5B2L-A nrPDB Length = 324 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 35/184 (19%), Positives = 55/184 (29%), Gaps = 24/184 (13%) Query: 52 KYRPPKRYRHPQIDQALTKHRTLNESRLLAKL-YLIPGLCVPQLIACD-----PYNGFIW 105 K R K + Q R+L L ++ P ++ C + FI Sbjct: 35 KMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIA 94 Query: 106 LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSS 165 +E +G S K M P L T+ V L + H D+ S Sbjct: 95 MELMGT--------SAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPS 146 Query: 166 NIVLVRDGARWTPHLIDFGLGSV---SNLVEDKGVDLYVLERAILS----THSKHAEKYN 218 NI+L G L DFG+ S + + T + + + Sbjct: 147 NILLDERGQ---IKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRAD 203 Query: 219 AWIM 222 W + Sbjct: 204 VWSL 207 >2LAV-A nrPDB Length = 361 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 ++ + +H ++Y HGD+ +SN++L +L+D+GL Sbjct: 160 RILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 201 >3DTC-A nrPDB Length = 271 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 30/146 (20%), Positives = 51/146 (34%), Gaps = 29/146 (19%) Query: 55 PPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC-----DPYNGFIWLEFL 109 P D + T E++L A L P +IA N + +EF Sbjct: 35 VKAARHDPDEDISQTIENVRQEAKLFAMLK------HPNIIALRGVCLKEPNLCLVMEF- 87 Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN---DYCHGDLTSSN 166 G + + + + D++ ++ R + LH H DL SSN Sbjct: 88 ----ARGGPLNRVLSGKRI-----PPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSN 138 Query: 167 IVLVR-----DGARWTPHLIDFGLGS 187 I++++ D + + DFGL Sbjct: 139 ILILQKVENGDLSNKILKITDFGLAR 164 >4UYA-A nrPDB Length = 340 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 45/142 (31%), Gaps = 21/142 (14%) Query: 55 PPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDL 113 + P+ D A E+RL A L P +I L + E Sbjct: 54 VKAARQDPEQDAAAAAESVRREARLFAMLR------HPNIIELRGVCLQQPHLCLVLEFA 107 Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYC---HGDLTSSNIVLV 170 GG L + ++ R + LH + H DL SSNI+L+ Sbjct: 108 RGGALNRALAGRRIPPHVLVNWAV------QIARGMLYLHEEAFVPILHRDLKSSNILLL 161 Query: 171 R-----DGARWTPHLIDFGLGS 187 D T + DFGL Sbjct: 162 EKIEHDDICNKTLKITDFGLAR 183 >5DMZ-A nrPDB Length = 365 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 30/84 (35%), Gaps = 8/84 (9%) Query: 109 LGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIV 168 +GE G + + + ++ LV + ++ I +H + HGD+ N + Sbjct: 145 VGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFI 204 Query: 169 L--------VRDGARWTPHLIDFG 184 L D LID G Sbjct: 205 LGNGFLEQDDEDDLSAGLALIDLG 228 >2Y4I-B nrPDB Length = 319 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 44/120 (36%), Gaps = 17/120 (14%) Query: 106 LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSS 165 L + G +S +++ + D + + ++ +G LH H DL S Sbjct: 104 LAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVK----GMGYLHAKGILHKDLKSK 159 Query: 166 NIVLVRDGARWTPHLIDFGLGSVSNLV-----EDKG----VDLYVLERAILSTHSKHAEK 216 N+ + DFGL S+S ++ EDK L L I+ S E+ Sbjct: 160 NVFYD----NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEE 215 >2RSV-A nrPDB Length = 403 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 ++ + +H ++Y HGD+ +SN++L +L+D+GL Sbjct: 167 RILDILEYIHEHEYVHGDIKASNLLLNYKNPD-QVYLVDYGLA 208 >6HMD-A nrPDB Length = 365 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 31/82 (37%), Gaps = 5/82 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---KGVDLY 200 ++ + + H H D+ N+++ + LID+GL + ++ + Y Sbjct: 155 ELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYHPAQEYNVRVASRY 212 Query: 201 VLERAILSTHSKHAEKYNAWIM 222 +L + + + W + Sbjct: 213 FKGPELLVDYQMYDYSLDMWSL 234 >4MD7-E nrPDB Length = 391 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 32/82 (39%), Gaps = 5/82 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---KGVDLY 200 ++ + + H H D+ N+++ + + LID+GL + ++ + Y Sbjct: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRY 196 Query: 201 VLERAILSTHSKHAEKYNAWIM 222 +L + + + W + Sbjct: 197 FKGPELLVDYQMYDYSLDMWSL 218 >2XYN-A nrPDB Length = 292 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 44/123 (35%), Gaps = 13/123 (10%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIA----CDPYNGFIWLEFLGEDLPGGHGFSNLKNF 125 K T+ L + ++ + P L+ C F + E +P G+ L+ Sbjct: 66 KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYI---VTEYMPYGNLLDYLREC 122 Query: 126 LWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 +AT ++ + L ++ H DL + N ++ G + DFGL Sbjct: 123 NREEVTAVVLLYMAT---QISSAMEYLEKKNFIHRDLAARNCLV---GENHVVKVADFGL 176 Query: 186 GSV 188 + Sbjct: 177 SRL 179 >1FVR-A nrPDB Length = 327 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 32/156 (20%), Positives = 62/156 (39%), Gaps = 24/156 (15%) Query: 50 IIKYRPPK-RYRHPQIDQALTKHRTLNESRLLA-KLYLIPGLCV-PQLIACD---PYNGF 103 ++K R K R + + ++ + ++ R A +L ++ L P +I + G+ Sbjct: 41 VLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGY 100 Query: 104 IWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLR------------KVGRQIGL 151 ++L E P G+ L+ + + DP + +T V R + Sbjct: 101 LYLAI--EYAPHGNLLDFLR-KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDY 157 Query: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 L + H DL + NI++ G + + DFGL Sbjct: 158 LSQKQFIHRDLAARNILV---GENYVAKIADFGLSR 190 >6GVJ-A nrPDB Length = 429 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 10/79 (12%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG------SVSNLVEDKG 196 + + + +H + H DL +N ++V LIDFG+ + S + + + Sbjct: 250 KNMLEAVHTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQV 305 Query: 197 VDLYVLERAILSTHSKHAE 215 + + + S E Sbjct: 306 GTVNYMPPEAIKDMSSSRE 324 >3NYO-A nrPDB Length = 576 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 39/110 (35%), Gaps = 10/110 (9%) Query: 148 QIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG---SVSNLVEDKGVDLYVLER 204 + LH + DL NI+L G + D GL ++ + + + Sbjct: 298 GLEDLHRERIVYRDLKPENILLDDHG---HIRISDLGLAVHVPEGQTIKGRVGTVGYMAP 354 Query: 205 AILSTH-SKHAEKYNAWIMEGFEEVYRE---QGAKGAKKLKEVTKRFEEV 250 ++ + + A +E + + Q K K +EV + +EV Sbjct: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 >3OZ6-A nrPDB Length = 388 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 35/107 (32%), Gaps = 28/107 (26%) Query: 141 TLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS------------- 187 + ++ + I LH H D+ SNI+L A + DFGL Sbjct: 114 VVYQLIKVIKYLHSGGLLHRDMKPSNILL---NAECHVKVADFGLSRSFVNIRRVTNNIP 170 Query: 188 ------VSNLVEDK------GVDLYVLERAILSTHSKHAEKYNAWIM 222 N +D+ + IL +K+ + + W + Sbjct: 171 LSINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSL 217 >4NT4-A nrPDB Length = 312 Score = 38.2 bits (87), Expect = 0.003, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 21/49 (42%), Gaps = 2/49 (4%) Query: 141 TLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG--ARWTPHLIDFGLGS 187 +++ +I +H + D+ N ++ R H+IDFGL Sbjct: 119 IAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAK 167 >5X18-A nrPDB Length = 295 Score = 38.2 bits (87), Expect = 0.003, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 41/116 (35%), Gaps = 8/116 (6%) Query: 76 ESRLLAKLYLIPGL--CVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 E+ L Y + P + PY + E L L +L++ + Sbjct: 45 EAPQLRDEYKTYKILNGTPNI----PYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKF 100 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR--WTPHLIDFGLGS 187 V ++ I LH +D + D+ N ++ R G HLIDFG+ Sbjct: 101 SVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAK 156 >5AMN-A nrPDB Length = 299 Score = 38.2 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 39/115 (33%), Gaps = 9/115 (7%) Query: 79 LLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 LL++ ++ + P +I +G + L GF + D + Sbjct: 73 LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERA 132 Query: 136 DLVATTLR---KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + + ++ + + L H DL + NI++ + DFGL Sbjct: 133 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK---MKISDFGLSR 184 >4FL3-A nrPDB Length = 635 Score = 37.8 bits (86), Expect = 0.004, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 44/116 (37%), Gaps = 8/116 (6%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 LLA+ ++ L P ++ + E G L+ + D++ + Sbjct: 417 LLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN-----I 471 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 + +V + L +++ H DL + N++LV + DFGL E+ Sbjct: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA---KISDFGLSKALRADEN 524 >4F9B-A nrPDB Length = 361 Score = 37.8 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 9/71 (12%) Query: 117 HGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARW 176 F ++ N L + Y + L+++ H H D+ SN + R ++ Sbjct: 105 ESFLDILNSLSFQEVREYMLNLFKALKRI-------HQFGIVHRDVKPSNFLYNRRLKKY 157 Query: 177 TPHLIDFGLGS 187 L+DFGL Sbjct: 158 A--LVDFGLAQ 166 >4E20-A nrPDB Length = 290 Score = 37.8 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 42/115 (36%), Gaps = 12/115 (10%) Query: 77 SRLLAKLYLIPGLCVPQLIA---CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 S ++ ++ L ++ C G ++ + E +P G +L H Sbjct: 55 SGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRD----YLPRHCVGL 110 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 L+ +++ + LH Y H L + N++L D + DFGL Sbjct: 111 AQLLL--FAQQICEGMAYLHAQHYIHRALAARNVLLDNDRL---VKIGDFGLAKA 160 >5X8I-B nrPDB Length = 346 Score = 37.8 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 15/102 (14%), Positives = 31/102 (30%), Gaps = 18/102 (17%) Query: 136 DLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL----------------VRDGARWTPH 179 D + ++ + + LH N H DL NI+ R Sbjct: 117 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 176 Query: 180 LIDFGLGSVSNLVEDKGV-DLYVLERAILSTHSKHAEKYNAW 220 ++DFG + + V + ++ ++ + W Sbjct: 177 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALG-WSQPCDVW 217 >5VDK-A nrPDB Length = 297 Score = 37.8 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 26/169 (15%), Positives = 51/169 (30%), Gaps = 21/169 (12%) Query: 75 NESRLLAKLYLIPGLCV-PQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 NE+ L ++Y L P ++ + + G + Sbjct: 57 NENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHF 116 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVL--------------VRDGARWTP- 178 + L ++ + +H + H D+ SNI + V + A W Sbjct: 117 EEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLS 176 Query: 179 -----HLIDFGLGSVSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIM 222 + D G + N + + D L IL +H K + + + Sbjct: 177 ANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFAL 225 >6EII-A nrPDB Length = 352 Score = 37.4 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 12/82 (14%), Positives = 32/82 (39%), Gaps = 5/82 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---KGVDLY 200 ++ + + H H D+ N+++ + + LID+GL + ++ + Y Sbjct: 162 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYHPGQEYNVRVASRY 219 Query: 201 VLERAILSTHSKHAEKYNAWIM 222 +L + + + W + Sbjct: 220 FKGPELLVDYQMYDYSLDMWSL 241 >4PL5-B nrPDB Length = 435 Score = 37.4 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 36/110 (32%), Gaps = 7/110 (6%) Query: 81 AKLYLIPGLC-VPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 ++ L+ P +I +++ +L ++ + H Sbjct: 69 REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI---- 124 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH--LIDFGLGS 187 T L + + LH + H DL NI+L A + DFGL Sbjct: 125 TLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCK 174 >6HV0-A nrPDB Length = 416 Score = 37.4 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 19/110 (17%), Positives = 37/110 (33%), Gaps = 7/110 (6%) Query: 81 AKLYLIPGLC-VPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 ++ L+ P +I +++ +L ++ + H Sbjct: 50 REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI---- 105 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH--LIDFGLGS 187 T L++ + LH + H DL NI++ A + DFGL Sbjct: 106 TLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCK 155 >3ORP-A nrPDB Length = 311 Score = 37.4 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 39/120 (32%), Gaps = 21/120 (17%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNG---------FIWLEFLGEDLPGGHGFSNLKNFLWM 128 R + L P ++A +I +E++ ++ + Sbjct: 58 RFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGV-----TLRDIVHTEGP 112 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 +++A + + H N H D+ +NI++ A ++DFG+ Sbjct: 113 MTPKRAIEVIADAC----QALNFSHQNGIIHRDVKPANIMI---SATNAVKVMDFGIARA 165 >5C26-A nrPDB Length = 299 Score = 37.4 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 44/116 (37%), Gaps = 8/116 (6%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 LLA+ ++ L P ++ + E G L+ + D++ + Sbjct: 75 LLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN-----I 129 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 + +V + L +++ H DL + N++LV + DFGL E+ Sbjct: 130 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA---KISDFGLSKALRADEN 182 >2PVN-A nrPDB Length = 352 Score = 37.4 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 12/84 (14%), Positives = 32/84 (38%), Gaps = 5/84 (5%) Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---KGVD 198 + ++ + + H H D+ N+++ + + LID+GL + ++ + Sbjct: 152 IYELLKALDYCHSQGIMHRDVKPHNVMIDHELRK--LRLIDWGLAEFYHPGKEYNVRVAS 209 Query: 199 LYVLERAILSTHSKHAEKYNAWIM 222 Y +L + + W + Sbjct: 210 RYFKGPELLVDLQDYDYSLDMWSL 233 >5AP3-A nrPDB Length = 313 Score = 37.4 bits (85), Expect = 0.007, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 10/79 (12%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG------SVSNLVEDKG 196 + + + +H + H DL +N ++V LIDFG+ + S + + + Sbjct: 134 KNMLEAVHTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQV 189 Query: 197 VDLYVLERAILSTHSKHAE 215 + + + S E Sbjct: 190 GTVNYMPPEAIKDMSSSRE 208 >3PP0-A nrPDB Length = 338 Score = 37.0 bits (84), Expect = 0.007, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 48/116 (41%), Gaps = 9/116 (7%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLK-NFLWMHDQDPYSDL 137 +L + Y++ G+ P + ++ + + +P G +++ N + QD + Sbjct: 66 ILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWC 125 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 + ++ + + L H DL + N+++ + DFGL + ++ E Sbjct: 126 M-----QIAKGMSYLEDVRLVHRDLAARNVLVKSPN---HVKITDFGLARLLDIDE 173 >3PG1-A nrPDB Length = 362 Score = 37.0 bits (84), Expect = 0.007, Method: Composition-based stats. Identities = 18/147 (12%), Positives = 43/147 (29%), Gaps = 7/147 (4%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGF-SNLKNFLWMHDQDPYSD 136 R+L ++ L+ P ++ + + ++L + Sbjct: 75 RVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQ 134 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDK- 195 + + + + +LH H DL NI+L + + DF L +K Sbjct: 135 HIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNN---DITICDFNLAREDTADANKT 191 Query: 196 --GVDLYVLERAILSTHSKHAEKYNAW 220 + ++ + + W Sbjct: 192 HYVTHRWYRAPELVMQFKGFTKLVDMW 218 >3HMP-A nrPDB Length = 342 Score = 37.0 bits (84), Expect = 0.008, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 10/79 (12%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG------SVSNLVEDKG 196 + + + +H + H DL +N ++V LIDFG+ + S + + + Sbjct: 162 KNMLEAVHTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQV 217 Query: 197 VDLYVLERAILSTHSKHAE 215 + + + S E Sbjct: 218 GTVNYMPPEAIKDMSSSRE 236 >5XVU-A nrPDB Length = 332 Score = 37.0 bits (84), Expect = 0.008, Method: Composition-based stats. Identities = 12/84 (14%), Positives = 31/84 (36%), Gaps = 5/84 (5%) Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---KGVD 198 + ++ + + H H D+ NI++ + + LI +GL + ++ + Sbjct: 131 IYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQ--IRLISWGLAEFYHPGQEYNVRVAS 188 Query: 199 LYVLERAILSTHSKHAEKYNAWIM 222 Y +L + + W + Sbjct: 189 RYYKGPELLIDLQLYDYSLDIWSL 212 >6CTH-A nrPDB Length = 309 Score = 37.0 bits (84), Expect = 0.008, Method: Composition-based stats. Identities = 24/153 (15%), Positives = 56/153 (36%), Gaps = 21/153 (13%) Query: 79 LLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 +++ +I L L+ G + L + E + G S++ + Sbjct: 59 YASEVKIISRLRHKNLVKLIGWCHERGELMLVY--EFMANGSLDSHIFKGKSL----LTW 112 Query: 136 DLVATTLRKVGRQIGLLHWND---YCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 ++ ++ + + LH H D+ +SNI+L + L DFGL + + Sbjct: 113 EVRYRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDS---SFNAKLGDFGLARLVDHA 169 Query: 193 ED-----KGVDLYVLERAILSTHSKHAEKYNAW 220 + + + LS+ K +++ + + Sbjct: 170 KGLKKTLLAGTVGYMAPECLSS-GKASKESDVY 201 >4XEY-B nrPDB Length = 408 Score = 37.0 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 45/122 (36%), Gaps = 11/122 (9%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGF---IWLEFLGEDLPGGHGFSNLKNFL 126 K T+ L + ++ + P L+ ++ + E + G+ L+ Sbjct: 159 KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI--ITEFMTYGNLLDYLRECN 216 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 Q+ + ++ ++ + L ++ H DL + N ++ G + DFGL Sbjct: 217 R---QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV---GENHLVKVADFGLS 270 Query: 187 SV 188 + Sbjct: 271 RL 272 >6NPU-A nrPDB Length = 298 Score = 37.0 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 45/122 (36%), Gaps = 11/122 (9%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGF---IWLEFLGEDLPGGHGFSNLKNFL 126 K T+ L + ++ + P L+ ++ + E + G+ L+ Sbjct: 60 KEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYI--ITEFMTYGNLLDYLRECN 117 Query: 127 WMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 Q+ + ++ ++ + L ++ H DL + N ++ G + DFGL Sbjct: 118 R---QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV---GENHLVKVADFGLS 171 Query: 187 SV 188 + Sbjct: 172 RL 173 >4Y12-A nrPDB Length = 375 Score = 36.7 bits (83), Expect = 0.009, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 40/136 (29%), Gaps = 25/136 (18%) Query: 84 YLIPGLCVPQLIACDPYN----------GFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 + + P ++ + G+I +E++G ++ Q Sbjct: 170 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG-----------QSLKRSKGQKL 218 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 L ++ + LH + DL NI+L + LID G S N Sbjct: 219 PVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE----QLKLIDLGAVSRINSFG 274 Query: 194 DKGVDLYVLERAILST 209 I+ T Sbjct: 275 YLYGTPGFQAPEIVRT 290 >2PZI-A nrPDB Length = 681 Score = 36.7 bits (83), Expect = 0.009, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 40/136 (29%), Gaps = 25/136 (18%) Query: 84 YLIPGLCVPQLIACDPYN----------GFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 + + P ++ + G+I +E++G ++ Q Sbjct: 131 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG-----------QSLKRSKGQKL 179 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 L ++ + LH + DL NI+L + LID G S N Sbjct: 180 PVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE----QLKLIDLGAVSRINSFG 235 Query: 194 DKGVDLYVLERAILST 209 I+ T Sbjct: 236 YLYGTPGFQAPEIVRT 251 >1LUF-A nrPDB Length = 343 Score = 36.7 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 44/128 (34%), Gaps = 19/128 (14%) Query: 75 NESRLLAK-----LYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPG-------GHGFSNL 122 E+ L+A+ + + G+C C + ++ L E L S+L Sbjct: 99 REAALMAEFDNPNIVKLLGVCAVGKPMCLLFE-YMAYGDLNEFLRSMSPHTVCSLSHSDL 157 Query: 123 KNFLWMHDQDPYSDLVATTL---RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 + P A L R+V + L + H DL + N ++ G Sbjct: 158 STRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLV---GENMVVK 214 Query: 180 LIDFGLGS 187 + DFGL Sbjct: 215 IADFGLSR 222 >2A1A-B nrPDB Length = 284 Score = 36.7 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 33/91 (36%), Gaps = 7/91 (7%) Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 L ++ + + +H + DL SNI LV + DFGL + Sbjct: 121 KVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQ---VKIGDFGLVTSLKNDGK 177 Query: 195 KG---VDLYVLERAILSTHSKHAEKYNAWIM 222 + L + +S+ + ++ + + + Sbjct: 178 RTRSKGTLRYMSPEQISSQ-DYGKEVDLYAL 207 >4M66-A nrPDB Length = 325 Score = 36.7 bits (83), Expect = 0.011, Method: Composition-based stats. Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 5/53 (9%) Query: 137 LVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 L+ L++V + LH D H DL SNI+L L DFGL + Sbjct: 117 LLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLD---PELHAKLADFGLST 166 >3RAW-A nrPDB Length = 381 Score = 36.7 bits (83), Expect = 0.012, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 26/93 (27%), Gaps = 16/93 (17%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVL----------------VRDGARWTPHLIDFGLGS 187 ++ + LH N H DL NI+ + + + DFG + Sbjct: 163 QLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT 222 Query: 188 VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + V + A+ + W Sbjct: 223 FDHEHHTTIVATRHYRPPEVILELGWAQPCDVW 255 >5HLW-A nrPDB Length = 299 Score = 36.3 bits (82), Expect = 0.013, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 47/118 (39%), Gaps = 19/118 (16%) Query: 77 SRLLAKLYLIPGLCVPQLIAC------DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 S+ L + ++ P +++ + + L ++ +L+NF+ Sbjct: 66 SQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--------GDLRNFIRNET 117 Query: 131 QDPY-SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 +P DL+ L +V + + L + H DL + N +L +T + DFGL Sbjct: 118 HNPTVKDLIGFGL-QVAKGMKYLASKKFVHRDLAARNCMLDEK---FTVKVADFGLAR 171 >2QKW-B nrPDB Length = 321 Score = 36.3 bits (82), Expect = 0.014, Method: Composition-based stats. Identities = 13/41 (31%), Positives = 20/41 (48%), Gaps = 3/41 (7%) Query: 147 RQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 R + LH H D+ S NI+L + + P + DFG+ Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLDEN---FVPKITDFGISK 187 >5CEK-A nrPDB Length = 263 Score = 36.3 bits (82), Expect = 0.014, Method: Composition-based stats. Identities = 17/112 (15%), Positives = 39/112 (34%), Gaps = 11/112 (9%) Query: 116 GHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR 175 G S +++ + +++ A +++ + H + GDL V + R Sbjct: 85 GDMHSYVRSRKRLREEE-----AARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE-ER 138 Query: 176 WTPHLIDFGLGSVSNLVEDKGVDLY----VLERAILSTHSKHAEK-YNAWIM 222 L + +D D + + IL+T ++ K + W + Sbjct: 139 TQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSL 190 >6DC0-A nrPDB Length = 292 Score = 36.3 bits (82), Expect = 0.014, Method: Composition-based stats. Identities = 17/112 (15%), Positives = 39/112 (34%), Gaps = 11/112 (9%) Query: 116 GHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGAR 175 G S +++ + +++ A +++ + H + GDL V + R Sbjct: 82 GDMHSYVRSRKRLREEE-----AARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE-ER 135 Query: 176 WTPHLIDFGLGSVSNLVEDKGVDLY----VLERAILSTHSKHAEK-YNAWIM 222 L + +D D + + IL+T ++ K + W + Sbjct: 136 TQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSL 187 >6DBN-A nrPDB Length = 316 Score = 36.3 bits (82), Expect = 0.014, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 50/155 (32%), Gaps = 20/155 (12%) Query: 77 SRLLAKLYLIPGLCVPQLIA----CDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQD 132 + L ++ ++ L ++ C G ++ + E LP G L + Sbjct: 82 ADLKKEIEILRNLYHENIVKYKGICTEDGGN-GIKLIMEFLPSGSLKEYLPKNKNKINLK 140 Query: 133 PYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLV 192 ++ + + L Y H DL + N+++ + + DFGL Sbjct: 141 QQLKYAV----QICKGMDYLGSRQYVHRDLAARNVLVESEHQ---VKIGDFGLTKAIETD 193 Query: 193 E-------DKGVDLYVLERAILSTHSKHAEKYNAW 220 + D+ ++ L SK + W Sbjct: 194 KEYYTVKDDRDSPVFWYAPECL-MQSKFYIASDVW 227 >2C47-A nrPDB Length = 313 Score = 36.3 bits (82), Expect = 0.015, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 22/46 (47%), Gaps = 2/46 (4%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDG--ARWTPHLIDFGLGS 187 ++ ++ +H + D+ N ++ R G + H+IDFGL Sbjct: 108 QLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAK 153 >4F0G-A nrPDB Length = 287 Score = 36.3 bits (82), Expect = 0.015, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 51/149 (34%), Gaps = 17/149 (11%) Query: 81 AKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 +++++ L P ++ + +EF+ P G + L + + Sbjct: 72 REVFIMSNLNHPNIVKLYGLMHNPPRMVMEFV----PCGDLYHRLLDKA----HPIKWSV 123 Query: 138 VATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVR--DGARWTPHLIDFGLGSVS-NLV 192 + + I + + H DL S NI L + A + DFGL S + V Sbjct: 124 KLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSV 183 Query: 193 EDKGVDLYVLERAILSTHSK-HAEKYNAW 220 + + + + + EK + + Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEKADTY 212 >4LFI-A nrPDB Length = 374 Score = 36.3 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 11/80 (13%), Positives = 30/80 (37%), Gaps = 5/80 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED---KGVDLY 200 ++ + + H H D+ N+++ + LID+GL ++ + + + Sbjct: 180 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHVNMEYNVRVASRF 237 Query: 201 VLERAILSTHSKHAEKYNAW 220 +L + + + W Sbjct: 238 FKGPELLVDYRMYDYSLDLW 257 >4JLC-A nrPDB Length = 657 Score = 35.9 bits (81), Expect = 0.018, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 55/156 (35%), Gaps = 18/156 (11%) Query: 80 LAKLYLIPGLCVPQL---IACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 + + ++ L + A + + E P G ++ L+ + Sbjct: 54 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 113 Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIV-LVRDGARWTPHLIDFGLGSVSNLVEDK 195 L+ LR V + L N H D+ NI+ ++ + + L DFG +++ Sbjct: 114 LI--VLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAR-ELEDDEQ 170 Query: 196 GVDLY---------VLERAILSTHS--KHAEKYNAW 220 V LY + ERA+L K+ + W Sbjct: 171 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLW 206 >2R2P-A nrPDB Length = 295 Score = 35.9 bits (81), Expect = 0.018, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 43/127 (33%), Gaps = 7/127 (5%) Query: 73 TLNESR-LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQ 131 T + R L + ++ P +I + G + + +L FL +D Sbjct: 63 TEKQRRDFLGEASIMGQFDHPNIIHLE---GVVTKSKPVMIVTEYMENGSLDTFLKKNDG 119 Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNL 191 + LR + + L Y H DL + NI++ + + DFGL V Sbjct: 120 QFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSN---LVCKVSDFGLSRVLED 176 Query: 192 VEDKGVD 198 + Sbjct: 177 DPEAAYT 183 >3A4O-X nrPDB Length = 286 Score = 35.9 bits (81), Expect = 0.019, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 47/129 (36%), Gaps = 11/129 (8%) Query: 63 QIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGF---IWLEFLGEDLPGGHGF 119 ++ K T++ L + L+ L +L+ I++ + E + G Sbjct: 39 KVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYI--ITEYMAKGSLL 96 Query: 120 SNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPH 179 LK+ P + ++ + + +Y H DL ++N+++ Sbjct: 97 DFLKSDEGGKVLLPK---LIDFSAQIAEGMAYIERKNYIHRDLRAANVLV---SESLMCK 150 Query: 180 LIDFGLGSV 188 + DFGL V Sbjct: 151 IADFGLARV 159 >2CHL-A nrPDB Length = 351 Score = 35.5 bits (80), Expect = 0.021, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 22/46 (47%), Gaps = 2/46 (4%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT--PHLIDFGLGS 187 ++ ++ +H + + D+ N ++ R G + H+IDF L Sbjct: 134 QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAK 179 >3A8W-A nrPDB Length = 345 Score = 35.5 bits (80), Expect = 0.022, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 40/122 (32%), Gaps = 13/122 (10%) Query: 91 VPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI 149 P L+ + L F+ E + GG +++ + ++ +L + Sbjct: 69 HPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL-----AL 123 Query: 150 GLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKG----VDLYVLERA 205 LH + DL N++L +G L D+G+ D + Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEG---HIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPE 180 Query: 206 IL 207 IL Sbjct: 181 IL 182 >2ZMD-A nrPDB Length = 390 Score = 35.5 bits (80), Expect = 0.023, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 10/79 (12%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG------SVSNLVEDKG 196 + + + +H + H DL +N ++V LIDFG+ + S + + + Sbjct: 162 KNMLEAVHTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQV 217 Query: 197 VDLYVLERAILSTHSKHAE 215 + + + S E Sbjct: 218 GAVNYMPPEAIKDMSSSRE 236 >2X7G-A nrPDB Length = 389 Score = 35.5 bits (80), Expect = 0.023, Method: Composition-based stats. Identities = 11/38 (28%), Positives = 19/38 (50%), Gaps = 1/38 (2%) Query: 138 VATTLRKVGRQIGLLH-WNDYCHGDLTSSNIVLVRDGA 174 V + +R+V + + LH H D+ NI++ D A Sbjct: 142 VKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDA 179 >5FM2-A nrPDB Length = 355 Score = 35.5 bits (80), Expect = 0.025, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 40/129 (31%), Gaps = 23/129 (17%) Query: 79 LLAKLYLIPGLCVPQLIACD-------------PYNGFIWLE-FLGEDLPGGHGFSNLKN 124 LL++ ++ + P +I Y + L FL E G G+ Sbjct: 114 LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGG 173 Query: 125 FLWMHDQDPYSDLVATTLR------KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP 178 D + T ++ + + L H DL + NI++ Sbjct: 174 SRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK---M 230 Query: 179 HLIDFGLGS 187 + DFGL Sbjct: 231 KISDFGLSR 239 >5OAT-A nrPDB Length = 411 Score = 35.5 bits (80), Expect = 0.026, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 42/139 (30%), Gaps = 21/139 (15%) Query: 90 CVPQLIACDPYNGFIWLEFLGEDL-PGGHGFSNLK---------NFLWMHDQDPYSDLVA 139 P ++A ++ L L P G G + N P + Sbjct: 97 PHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSL 156 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI-DFGLGSVSNL------- 191 L ++ + + + H DL S N++L +I DFG Sbjct: 157 LLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPY 216 Query: 192 ---VEDKGVDLYVLERAIL 207 DKG + ++ I+ Sbjct: 217 TSYEMDKGGNTALMAPEII 235 >1PY5-A nrPDB Length = 326 Score = 35.1 bits (79), Expect = 0.028, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 56/184 (30%), Gaps = 24/184 (13%) Query: 58 RYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC----DPYNG-FIWLEFLGED 112 ++R ++ + R A++Y L ++ + NG + L + + Sbjct: 49 KWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDY 108 Query: 113 LPGGHGFSNLKNFLWMHD--QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLV 170 G F L + + + +G H DL S NI++ Sbjct: 109 HEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVK 168 Query: 171 RDGARWTPHLIDFGLGSVSNLVED--------KGVDLYVLERAILSTHSKHAEKYNAWIM 222 ++G T + D GL + D + + +L + N Sbjct: 169 KNG---TCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVL------DDSINMKHF 219 Query: 223 EGFE 226 E F+ Sbjct: 220 ESFK 223 >3ALO-A nrPDB Length = 327 Score = 35.1 bits (79), Expect = 0.028, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%), Gaps = 3/31 (9%) Query: 156 DYCHGDLTSSNIVLVRDGARWTPHLIDFGLG 186 H D+ SNI+L R G L DFG+ Sbjct: 146 KIIHRDIKPSNILLDRSG---NIKLCDFGIS 173 >3C1X-A nrPDB Length = 373 Score = 35.1 bits (79), Expect = 0.031, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 47/118 (39%), Gaps = 19/118 (16%) Query: 77 SRLLAKLYLIPGLCVPQLIAC------DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHD 130 S+ L + ++ P +++ + + L ++ +L+NF+ Sbjct: 135 SQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--------GDLRNFIRNET 186 Query: 131 QDPY-SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 +P DL+ L +V + + L + H DL + N +L +T + DFGL Sbjct: 187 HNPTVKDLIGFGL-QVAKGMKFLASKKFVHRDLAARNCMLDEK---FTVKVADFGLAR 240 >4PDO-A nrPDB Length = 299 Score = 34.7 bits (78), Expect = 0.036, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 44/120 (36%), Gaps = 12/120 (10%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACD-PYNGFIWLEFLGEDLPGGHGFSNLKNFLWM 128 K R L + ++ +I + + + + + E + G L FL Sbjct: 78 KQRVD----FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENG----ALDKFLRE 129 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 D + + LR + + L +Y H DL + NI++ + + DFGL V Sbjct: 130 KDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSN---LVCKVSDFGLSRV 186 >6EQI-C nrPDB Length = 433 Score = 34.7 bits (78), Expect = 0.040, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 27/72 (37%), Gaps = 12/72 (16%) Query: 147 RQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLI--DFGLGSVSNL----------VED 194 + ++ ++ H DL S NI++ P ++ DFG +D Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 195 KGVDLYVLERAI 206 KG + ++ I Sbjct: 238 KGGNRALMAPEI 249 >5E8V-A nrPDB Length = 316 Score = 34.7 bits (78), Expect = 0.040, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 35/89 (39%), Gaps = 24/89 (26%) Query: 142 LRKVG----RQIGLLH---------WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLG-- 186 LRK+G R I LH H DL SSNI++ D T L DFGL Sbjct: 114 LRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKND---LTCCLCDFGLSLR 170 Query: 187 -----SVSNLVED-KGVDLYVLERAILST 209 SV +L + + +L++ Sbjct: 171 LDPTLSVDDLANSGQVGTARYMAPEVLAS 199 >4C59-A nrPDB Length = 340 Score = 34.7 bits (78), Expect = 0.041, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 21/54 (38%), Gaps = 5/54 (9%) Query: 136 DLVATTLRKVGRQIGLLHWND--YCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 D V + R + +H H DL N++L G T L DFG + Sbjct: 135 DTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQG---TIKLCDFGSAT 185 >1TKI-A nrPDB Length = 321 Score = 34.7 bits (78), Expect = 0.043, Method: Composition-based stats. Identities = 23/158 (14%), Positives = 51/158 (32%), Gaps = 25/158 (15%) Query: 43 KDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLC------------ 90 K+ ++KY+I + + T ++ +AK + G Sbjct: 1 KELYEKYMIAEDLGRG----EFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILN 56 Query: 91 ---VPQLIACDP-YNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVG 146 ++ + L + E + G F + + + + + +V Sbjct: 57 IARHRNILHLHESFESMEELVMIFEFISGLDIFERINT----SAFELNEREIVSYVHQVC 112 Query: 147 RQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + LH ++ H D+ NI+ T +I+FG Sbjct: 113 EALQFLHSHNIGHFDIRPENIIYQTR-RSSTIKIIEFG 149 >3AOX-A nrPDB Length = 344 Score = 34.7 bits (78), Expect = 0.044, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 37/115 (32%), Gaps = 3/115 (2%) Query: 76 ESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS 135 E L + +I ++ C + F+ +L G + P S Sbjct: 94 ELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSS 153 Query: 136 DLVATTL---RKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + L R + L N + H D+ + N +L G + DFG+ Sbjct: 154 LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR 208 >5X5O-A nrPDB Length = 310 Score = 34.7 bits (78), Expect = 0.045, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 32/103 (31%), Gaps = 10/103 (9%) Query: 112 DLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWN---DYCHGDLTSSNIV 168 + + N + D D + T V + + LH H DL S N+V Sbjct: 84 EYASLGSLYDYINSNRSEEMDM--DHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVV 141 Query: 169 LVRDGARWTPHLIDFGLGSVSNLVEDK--GVDLYVLERAILST 209 + DG + DFG N + ++ + Sbjct: 142 IAADGV---LKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS 181 >3DKO-A nrPDB Length = 318 Score = 34.3 bits (77), Expect = 0.049, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 42/119 (35%), Gaps = 11/119 (9%) Query: 73 TLNESR-LLAKLYLIPGLCVPQLIACD--PYNGFIWLEFLGEDLPGGHGFSNLKNFLWMH 129 T + R L + ++ P ++ + G + + G L FL H Sbjct: 84 TEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGA-----LDAFLRKH 138 Query: 130 DQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 D + LR + + L Y H DL + NI++ + + DFGL V Sbjct: 139 DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSN---LVCKVSDFGLSRV 194 >1CSN-A nrPDB Length = 298 Score = 34.3 bits (77), Expect = 0.050, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 35/85 (41%), Gaps = 2/85 (2%) Query: 103 FIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDL 162 + E L L +L++ L + + VA +++ ++ +H + D+ Sbjct: 73 YFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDI 132 Query: 163 TSSNIVLVR-DGARWT-PHLIDFGL 185 N ++ R + +++DFG+ Sbjct: 133 KPDNFLIGRPNSKNANMIYVVDFGM 157 >5MJB-A nrPDB Length = 305 Score = 34.3 bits (77), Expect = 0.055, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 41/118 (34%), Gaps = 10/118 (8%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMH 129 K R L++ ++ +I + G + + L +FL + Sbjct: 69 KQRRD----FLSEASIMGQFDHRNIIRLE---GVVTKSRPVMIITEFMENCALDSFLRQN 121 Query: 130 DQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 D + LR + + L +Y H DL + NI++ + + DFGL Sbjct: 122 DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSN---LVCKVSDFGLSR 176 >4BTK-A nrPDB Length = 337 Score = 34.0 bits (76), Expect = 0.071, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 21/46 (45%), Gaps = 1/46 (2%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVR-DGARWTPHLIDFGLGS 187 +++ I +H + H D+ SN + R +++DFGL Sbjct: 160 KQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 205 >3UIM-A nrPDB Length = 326 Score = 34.0 bits (76), Expect = 0.071, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 33/82 (40%), Gaps = 12/82 (14%) Query: 147 RQIGLLHWN---DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLY--- 200 R + LH + H D+ ++NI+L + + DFGL + + + Sbjct: 142 RGLAYLHDHCDPKIIHRDVKAANILLDEEFEAV---VGDFGLAKLMDYKDTHVTTAVRGT 198 Query: 201 --VLERAILSTHSKHAEKYNAW 220 + LST K +EK + + Sbjct: 199 IGHIAPEYLST-GKSSEKTDVF 219 >3CJF-A nrPDB Length = 309 Score = 34.0 bits (76), Expect = 0.078, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 31/87 (35%), Gaps = 14/87 (16%) Query: 119 FSNLKNFLWM--HDQDPYSDLVATTLR---------KVGRQIGLLHWNDYCHGDLTSSNI 167 F NL +L ++ PY DL L +V + + L H DL + NI Sbjct: 116 FGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNI 175 Query: 168 VLVRDGARWTPHLIDFGLGSVSNLVED 194 +L + DFGL D Sbjct: 176 LLSEKNV---VKICDFGLARDIYKDPD 199 >6FER-A nrPDB Length = 309 Score = 33.6 bits (75), Expect = 0.083, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 21/44 (47%), Gaps = 3/44 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 ++ + L ++ H DL + N ++ G +T + DFG+ Sbjct: 141 QIASGMKYLSSLNFVHRDLATRNCLV---GKNYTIKIADFGMSR 181 >4NFN-A nrPDB Length = 309 Score = 33.6 bits (75), Expect = 0.083, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 21/46 (45%), Gaps = 1/46 (2%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVR-DGARWTPHLIDFGLGS 187 +++ I +H + H D+ SN + R +++DFGL Sbjct: 125 KQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR 170 >4JRN-A nrPDB Length = 372 Score = 33.6 bits (75), Expect = 0.084, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 23/62 (37%), Gaps = 3/62 (4%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGVDLYVLE 203 + + + + H D+ +N +L++DG L DFG ++N V Sbjct: 210 QAIKLVANVQAQGIVHTDIKPANFLLLKDGR---LFLGDFGTYRINNSVGRAIGTPGYEP 266 Query: 204 RA 205 Sbjct: 267 PE 268 >3BBT-B nrPDB Length = 328 Score = 33.6 bits (75), Expect = 0.090, Method: Composition-based stats. Identities = 17/115 (14%), Positives = 41/115 (35%), Gaps = 7/115 (6%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 + + ++ + P L+ ++ + + +P G + H + S L+ Sbjct: 64 FMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHE----HKDNIGSQLL 119 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 ++ + + L H DL + N+++ + DFGL + E Sbjct: 120 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPN---HVKITDFGLARLLEGDE 171 >2WTK-B nrPDB Length = 373 Score = 33.2 bits (74), Expect = 0.11, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 46/113 (40%), Gaps = 10/113 (8%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL- 137 L +L++ P ++ PY + + + + K+ + H D ++L Sbjct: 57 LQGELHVSKLFNHPNIV---PYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELA 113 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGA------RWTPHLIDFG 184 +A L+ V + + +H Y H + +S+I++ DG R +I G Sbjct: 114 IAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHG 166 >3LZB-A nrPDB Length = 327 Score = 33.2 bits (74), Expect = 0.11, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 41/110 (37%), Gaps = 7/110 (6%) Query: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLV 138 +L + Y++ + P + I L + + F L +++ H + S + Sbjct: 64 ILDEAYVMASVDNPHVCRLLG----ICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYL 119 Query: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 ++ + + L H DL + N+++ + DFGL + Sbjct: 120 LNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKL 166 >3Q4U-A nrPDB Length = 301 Score = 33.2 bits (74), Expect = 0.12, Method: Composition-based stats. Identities = 22/149 (14%), Positives = 44/149 (29%), Gaps = 35/149 (23%) Query: 106 LEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA----------TTLRKVGRQIGLLH-- 153 L F+ D+ H + L H+ D + + + + LH Sbjct: 65 LGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIE 124 Query: 154 ------WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED--------KGVDL 199 H DL S NI++ ++G + D GL + + + + Sbjct: 125 IFGTQGKPAIAHRDLKSKNILVKKNGQCC---IADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 200 YVLERAILSTHSKHAEKYNAWIMEGFEEV 228 + +L E + ++ V Sbjct: 182 RYMAPEVL------DETIQVDCFDSYKRV 204 >3VHK-A nrPDB Length = 368 Score = 33.2 bits (74), Expect = 0.12, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 30/86 (34%), Gaps = 12/86 (13%) Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLR---------KVGRQIGLLHWNDYCHGDLTSSNIV 168 GF K+ + +++ DL L +V + + L H DL + NI+ Sbjct: 173 GFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNIL 232 Query: 169 LVRDGARWTPHLIDFGLGSVSNLVED 194 L + DFGL D Sbjct: 233 LSEKNV---VKICDFGLARDIYKDPD 255 >4H1J-A nrPDB Length = 293 Score = 33.2 bits (74), Expect = 0.13, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 46/119 (38%), Gaps = 17/119 (14%) Query: 74 LNESRLLAKLYLIPGLCVPQLIAC----DPYNGFIWLE-FLGEDLPGGHGFSNLKNFLWM 128 N+ + +++ ++ L P ++ + +I +E + +L GH KN L + Sbjct: 67 DNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGEL--GHYLERNKNSLKV 124 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 YS ++ + + L + H D+ NI++ L DFGL Sbjct: 125 LTLVLYSL-------QICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSR 173 >4EBW-A nrPDB Length = 304 Score = 32.8 bits (73), Expect = 0.14, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 39/117 (33%), Gaps = 10/117 (8%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 + L + + P ++ + + E G S L+ + D Sbjct: 85 KFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILY 144 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 ++ + L + H D+ + N+++ + L DFGL S +ED Sbjct: 145 AY----QLSTALAYLESKRFVHRDIAARNVLVSSNDC---VKLGDFGL---SRYMED 191 >4O1O-A nrPDB Length = 717 Score = 32.8 bits (73), Expect = 0.14, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 21/56 (37%) Query: 118 GFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDG 173 +L N + + L + + IG LH + Y H DL NI++ Sbjct: 424 LQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKN 479 >4WUA-A nrPDB Length = 401 Score = 32.8 bits (73), Expect = 0.14, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 16/33 (48%), Gaps = 1/33 (3%) Query: 138 VATTLRKVGRQIGLLH-WNDYCHGDLTSSNIVL 169 V +++V + + LH H D+ NI+L Sbjct: 152 VKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL 184 >5LPV-A nrPDB Length = 296 Score = 32.8 bits (73), Expect = 0.15, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 24/50 (48%), Gaps = 6/50 (12%) Query: 147 RQIGLLHWN---DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 R + LH N H D+ SSN++L + + DFG+ + + ++ Sbjct: 128 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEA---RVSDFGMARLMSAMD 174 >5LPZ-A nrPDB Length = 332 Score = 32.8 bits (73), Expect = 0.15, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 24/50 (48%), Gaps = 6/50 (12%) Query: 147 RQIGLLHWN---DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVE 193 R + LH N H D+ SSN++L + + DFG+ + + ++ Sbjct: 128 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEA---RVSDFGMARLMSAMD 174 >4IX6-A nrPDB Length = 350 Score = 32.8 bits (73), Expect = 0.17, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 22/49 (44%), Gaps = 3/49 (6%) Query: 137 LVATTLRKVGRQIGLLHWNDYCHGDLTSSNIV-LVRDGARWTPHLIDFG 184 + +R++ + LH H D+ +N++ +DG LID G Sbjct: 144 VTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGG--VLKLIDLG 190 >4XD0-A nrPDB Length = 417 Score = 32.4 bits (72), Expect = 0.18, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 43/123 (34%), Gaps = 7/123 (5%) Query: 59 YRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHG 118 Y++ ID T H L + R A + L P++ D ++G I G Sbjct: 215 YKNLMIDLNKTAHEILQQIR--AFTFRDYQL--PRIDDIDIFHGEILSSKSLSK--PGTI 268 Query: 119 FSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP 178 L + D L + ++ ++ L + NI+ ++ W+P Sbjct: 269 LEKNNYHLILSTIDYDIKLYSDNFDEILTACED-KSPEFISKLLKTENILFEKNHLGWSP 327 Query: 179 HLI 181 +I Sbjct: 328 III 330 >4LRM-A nrPDB Length = 334 Score = 32.4 bits (72), Expect = 0.18, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 28/70 (40%), Gaps = 3/70 (4%) Query: 119 FSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP 178 F L +++ H + S + ++ + + L H DL + N+++ Sbjct: 107 FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHV 163 Query: 179 HLIDFGLGSV 188 + DFGL + Sbjct: 164 KITDFGLAKL 173 >5GNK-A nrPDB Length = 297 Score = 32.4 bits (72), Expect = 0.19, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 28/70 (40%), Gaps = 3/70 (4%) Query: 119 FSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP 178 F L +++ H + S + ++ + + L H DL + N+++ Sbjct: 104 FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHV 160 Query: 179 HLIDFGLGSV 188 + DFGL + Sbjct: 161 KITDFGLAKL 170 >3I81-A nrPDB Length = 315 Score = 32.4 bits (72), Expect = 0.19, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 22/44 (50%), Gaps = 3/44 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 ++ + L+ N + H DL + N ++ D +T + DFG+ Sbjct: 139 EIADGMAYLNANKFVHRDLAARNCMVAED---FTVKIGDFGMTR 179 >3QGY-A nrPDB Length = 286 Score = 32.4 bits (72), Expect = 0.21, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 57/167 (34%), Gaps = 18/167 (10%) Query: 62 PQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACD---PYNGFIWLEFLGEDLPGGHG 118 ++ K +++E + + ++ L P+L+ I L F E + G Sbjct: 52 DKVAIKTIKEGSMSEDDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVF--EFMEHGCL 109 Query: 119 FSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTP 178 L+ + + + V + L H DL + N ++ G Sbjct: 110 SDYLRTQRGLFAAETLLGMCLD----VCEGMAYLEEACVIHRDLAARNCLV---GENQVI 162 Query: 179 HLIDFGLGS--VSNLVEDKGVDLYVLE---RAILSTHSKHAEKYNAW 220 + DFG+ + + + ++ + S S+++ K + W Sbjct: 163 KVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVW 208 >6FEX-A nrPDB Length = 321 Score = 32.4 bits (72), Expect = 0.21, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 48/146 (32%), Gaps = 26/146 (17%) Query: 43 KDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLC-VPQLIACDPYN 101 K++ ++ + + R + P I RLL LC + + N Sbjct: 71 KNARNDFLKEVKIMSRLKDPNI------------IRLLGVCVQDDPLCMITDYMENGDLN 118 Query: 102 GFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGD 161 F+ L + G ++ + ++ + L ++ H D Sbjct: 119 QFLSAHQLEDKAAEGAPGDPTISYPMLLHVAA----------QIASGMRYLATLNFVHRD 168 Query: 162 LTSSNIVLVRDGARWTPHLIDFGLGS 187 L + N ++ G +T + DFG+ Sbjct: 169 LATRNCLV---GENFTIKIADFGMSR 191 >2BUJ-A nrPDB Length = 317 Score = 32.4 bits (72), Expect = 0.22, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 45/124 (36%), Gaps = 19/124 (15%) Query: 70 KHRTLNESRLLAKLYLIPGLCVPQLIACDPY---------NGFIWLEFLGEDLPGGHGFS 120 + + E++ A ++ + P ++ Y ++ L F G ++ Sbjct: 66 EQQDREEAQREADMHRLFN--HPNILRLVAYCLRERGAKHEAWLLLPF----FKRGTLWN 119 Query: 121 NLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHL 180 + L D + L + R + +H Y H DL +NI+L G P L Sbjct: 120 EI-ERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILL---GDEGQPVL 175 Query: 181 IDFG 184 +D G Sbjct: 176 MDLG 179 >2J0K-A nrPDB Length = 656 Score = 32.0 bits (71), Expect = 0.26, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 39/117 (33%), Gaps = 10/117 (8%) Query: 78 RLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDL 137 + L + + P ++ + + E G S L+ + D Sbjct: 437 KFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILY 496 Query: 138 VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 ++ + L + H D+ + N+++ A L DFGL S +ED Sbjct: 497 AY----QLSTALAYLESKRFVHRDIAARNVLV---SATDCVKLGDFGL---SRYMED 543 >3VN9-A nrPDB Length = 340 Score = 32.0 bits (71), Expect = 0.27, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 26/82 (31%), Gaps = 8/82 (9%) Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL----LH-WNDYCHGDLTS 164 G+ + + D + L K+ I LH H D+ Sbjct: 123 GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKP 182 Query: 165 SNIVLVRDGARWTPHLIDFGLG 186 SN+++ G + DFG+ Sbjct: 183 SNVLINALGQ---VKMCDFGIS 201 >3FME-A nrPDB Length = 290 Score = 32.0 bits (71), Expect = 0.28, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 26/82 (31%), Gaps = 8/82 (9%) Query: 110 GEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL----LH-WNDYCHGDLTS 164 G+ + + D + L K+ I LH H D+ Sbjct: 79 GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKP 138 Query: 165 SNIVLVRDGARWTPHLIDFGLG 186 SN+++ G + DFG+ Sbjct: 139 SNVLINALGQ---VKMCDFGIS 157 >5VD3-A nrPDB Length = 311 Score = 32.0 bits (71), Expect = 0.29, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 43/108 (39%), Gaps = 11/108 (10%) Query: 142 LRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG----LGSVSNLVEDKGV 197 LR + LH H D+ +NI L G R L DFG LG+ E + Sbjct: 163 LRDTLLALAHLHSQGLVHLDVKPANIFL---GPRGRCKLGDFGLLVELGTAG-AGEVQEG 218 Query: 198 DLYVLERAILS-THSKHAE--KYNAWIMEGFEEVYREQGAKGAKKLKE 242 D + +L ++ A+ I+E + G +G ++L++ Sbjct: 219 DPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ 266 >5X1R-A nrPDB Length = 302 Score = 32.0 bits (71), Expect = 0.30, Method: Composition-based stats. Identities = 28/110 (25%), Positives = 43/110 (39%), Gaps = 12/110 (10%) Query: 75 NESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPY 134 E+RLLA+ PGL ++ NG ++G G + LKN + Sbjct: 88 QEARLLARFSH-PGLLH--VLRFWEENG---TAYMGTQFYSG---TTLKNLQAQQPEKID 138 Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 + L + I +H Y H D++ NI + P L+DFG Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQL---PVLLDFG 185 >6BSD-A nrPDB Length = 876 Score = 31.7 bits (70), Expect = 0.32, Method: Composition-based stats. Identities = 24/146 (16%), Positives = 47/146 (32%), Gaps = 20/146 (13%) Query: 43 KDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLC-VPQLIACDPYN 101 K++ ++ + + R + P I RLL LC + + N Sbjct: 626 KNARNDFLKEVKIMSRLKDPNI------------IRLLGVCVQDDPLCMITDYMENGDLN 673 Query: 102 GFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGD 161 F+ L + G + A ++ + L ++ H D Sbjct: 674 QFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAA----QIASGMRYLATLNFVHRD 729 Query: 162 LTSSNIVLVRDGARWTPHLIDFGLGS 187 L + N ++ G +T + DFG+ Sbjct: 730 LATRNCLV---GENFTIKIADFGMSR 752 >4L00-A nrPDB Length = 304 Score = 31.7 bits (70), Expect = 0.33, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 57/177 (32%), Gaps = 14/177 (7%) Query: 85 LIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRK 144 ++ + ++ + E+ G + P+ VA ++ Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVA---KQ 141 Query: 145 VGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWT----PHLIDFGLGSVSNLVEDKGVDLY 200 + + L D HG++ + N++L R+G L D G+ ++ + Sbjct: 142 LASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP 201 Query: 201 VLERAILSTHSKHAEKYNAWIMEGFEEVYREQGAKGAKKLKEVT----KRFEEVRLR 253 + + + + W F E G LK+ T +RF E R R Sbjct: 202 WIAPECVEDSKNLSVAADKW---SFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR 255 >4AT3-A nrPDB Length = 299 Score = 31.7 bits (70), Expect = 0.35, Method: Composition-based stats. Identities = 20/141 (14%), Positives = 46/141 (32%), Gaps = 18/141 (12%) Query: 62 PQIDQALTKHRTLNESR------LLAKLYLIPGLCVPQLIACD----PYNGFIWL-EFLG 110 P+ D+ L +TL ++ + L+ L ++ + I + E++ Sbjct: 39 PEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMK 98 Query: 111 ----EDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSN 166 HG + + + +++ + L + H DL + N Sbjct: 99 HGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRN 158 Query: 167 IVLVRDGARWTPHLIDFGLGS 187 ++ G + DFG+ Sbjct: 159 CLV---GENLLVKIGDFGMSR 176 >5U6B-A nrPDB Length = 307 Score = 31.7 bits (70), Expect = 0.36, Method: Composition-based stats. Identities = 17/117 (14%), Positives = 37/117 (31%), Gaps = 11/117 (9%) Query: 79 LLAKLYLIPGLCVPQLIAC-------DPYNGFIWLEFLGEDLPGGHGFSNLK-NFLWMHD 130 L++ + P ++ F + + G S L + L Sbjct: 71 FLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQP 130 Query: 131 QDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 + ++ + + + L + H DL + N +L + + + DFGL Sbjct: 131 VYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNEN---MSVCVADFGLSK 184 >5XD6-A nrPDB Length = 305 Score = 31.7 bits (70), Expect = 0.39, Method: Composition-based stats. Identities = 35/150 (23%), Positives = 53/150 (35%), Gaps = 16/150 (10%) Query: 76 ESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDL-PGGHGFSNLKNFLWMHDQDPY 134 + LA++ ++ L ++A Y L L + P G L + P Sbjct: 61 DQEFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPG 120 Query: 135 SDLVATTLRKVG----RQIGLLHWN---DYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 L K+ R + LH H D+ SSN++L D + DF L Sbjct: 121 PVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVA---KIADFDL-- 175 Query: 188 VSNLVEDKGVDLYVLERAILSTHSKHAEKY 217 SN D L+ +L T HA +Y Sbjct: 176 -SNQAPDMAARLH--STRVLGTFGYHAPEY 202 >2WTK-C nrPDB Length = 305 Score = 31.3 bits (69), Expect = 0.44, Method: Composition-based stats. Identities = 15/120 (12%), Positives = 37/120 (30%), Gaps = 18/120 (15%) Query: 76 ESRLLAKLYLIPGLCVPQLIAC-------DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWM 128 E+ + ++ L+ L +I + ++ +E+ + G + Sbjct: 50 EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYC---VCGMQEMLDSVPEKRF 106 Query: 129 HDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSV 188 + ++ + LH H D+ N++L G T + G+ Sbjct: 107 PVCQAHGYFC-----QLIDGLEYLHSQGIVHKDIKPGNLLLTTGG---TLKISALGVAEA 158 >2WO6-A nrPDB Length = 382 Score = 31.3 bits (69), Expect = 0.45, Method: Composition-based stats. Identities = 12/67 (17%), Positives = 23/67 (34%), Gaps = 3/67 (4%) Query: 157 YCHGDLTSSNIVLVRDGARWTPHLIDFGLG-SVSNLVEDKGVDLYVLERAILSTHSKHAE 215 H DL NI+L + R ++DFG + + + +L + Sbjct: 180 IIHCDLKPENILL-CNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGM-PYDL 237 Query: 216 KYNAWIM 222 + W + Sbjct: 238 AIDMWSL 244 >2JII-A nrPDB Length = 352 Score = 30.9 bits (68), Expect = 0.54, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 22/45 (48%), Gaps = 4/45 (8%) Query: 130 DQDPYSDLVATTLRKV----GRQIGLLHWNDYCHGDLTSSNIVLV 170 D P L ++ +V + LH N+Y HG++T+ NI + Sbjct: 149 DVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 >3HNG-A nrPDB Length = 360 Score = 30.9 bits (68), Expect = 0.56, Method: Composition-based stats. Identities = 13/44 (29%), Positives = 18/44 (40%), Gaps = 3/44 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 +V R + L H DL + NI+L + DFGL Sbjct: 207 QVARGMEFLSSRKCIHRDLAARNILL---SENNVVKICDFGLAR 247 >3V5Q-A nrPDB Length = 297 Score = 30.9 bits (68), Expect = 0.66, Method: Composition-based stats. Identities = 31/174 (17%), Positives = 55/174 (31%), Gaps = 23/174 (13%) Query: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLA 81 + +GA VF + P KD + K + P + R E+ LL Sbjct: 23 LGEGAFGKVFLAECYNLSP-TKDKMLVAV------KALKDPTLAARKDFQR---EAELLT 72 Query: 82 KLY-----LIPGLCV---PQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDP 133 L G+C P ++ + +FL P + + + Sbjct: 73 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 134 YSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 L ++ + L + H DL + N ++ GA + DFG+ Sbjct: 133 SQML--HIASQIASGMVYLASQHFVHRDLATRNCLV---GANLLVKIGDFGMSR 181 >5IKW-A nrPDB Length = 310 Score = 30.5 bits (67), Expect = 0.84, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 31/92 (33%), Gaps = 19/92 (20%) Query: 147 RQIGLLH--WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---------NLVED- 194 + LH H DL NI+L G L DFG + N+VE+ Sbjct: 129 EAVARLHQCKTPIIHRDLKVENILLNDGG---NYVLCDFGSATNKFLNPQKDGVNVVEEE 185 Query: 195 --KGVDLYVLERAILSTHSKH--AEKYNAWIM 222 K L +++ + K + W + Sbjct: 186 IKKYTTLSYRAPEMINLYGGKPITTKADIWAL 217 >6EF6-A nrPDB Length = 354 Score = 30.5 bits (67), Expect = 0.85, Method: Composition-based stats. Identities = 20/98 (20%), Positives = 35/98 (35%), Gaps = 13/98 (13%) Query: 135 SDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVED 194 DL+ L + G H DL +N+++ + T +IDF +D Sbjct: 208 QDLLHRKLEEYGSGP---DRYGLIHADLRLANLLVDSSTPQRTITVIDF---------DD 255 Query: 195 KGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYREQ 232 G Y + + +H + W E + YR + Sbjct: 256 CGFGWYFYDFGTAVSFIEHDPRLGEW-QESWVAGYRSR 292 >4IAN-A nrPDB Length = 358 Score = 30.1 bits (66), Expect = 0.89, Method: Composition-based stats. Identities = 30/171 (17%), Positives = 59/171 (34%), Gaps = 19/171 (11%) Query: 61 HPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHG-- 118 + ++ + ++ L + L +L + L DP + F L H Sbjct: 56 NQEVAVKIIRNNELMQKTGLKELEFLKKLN-----DADPDDKFHCLRLFRHFYHKQHLCL 110 Query: 119 -FSNLKNFLWMHDQDPYSDL------VATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVR 171 F L L + D+ V + +++ + LL + H D+ NI++ Sbjct: 111 VFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILV-- 168 Query: 172 DGARWTPHLIDFGLGS--VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAW 220 + ++ L DFG S N + V + I+ S + + W Sbjct: 169 NESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKS-YDYGIDMW 218 >1TQM-A nrPDB Length = 282 Score = 30.1 bits (66), Expect = 0.97, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 35/104 (33%), Gaps = 22/104 (21%) Query: 80 LAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVA 139 L + GL VP++ A G L + ++ + Sbjct: 155 FRALQKLQGLAVPKVYA----------------WEGNAVLMELIDAKELYRVRVENP--D 196 Query: 140 TTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 L + ++ + HGDL+ N+++ +G +IDF Sbjct: 197 EVLDMILEEVAKFYHRGIVHGDLSQYNVLVSEEG----IWIIDF 236 >5TE0-A nrPDB Length = 347 Score = 30.1 bits (66), Expect = 1.0, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 31/92 (33%), Gaps = 19/92 (20%) Query: 147 RQIGLLH--WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS---------NLVED- 194 + LH H DL NI+L G L DFG + N VED Sbjct: 135 EAVARLHQCKTPIIHRDLKVENILLHDRGHYV---LCDFGSATNKFQNPQTEGVNAVEDE 191 Query: 195 --KGVDLYVLERAILSTHSKH--AEKYNAWIM 222 K L +++ +S K + W + Sbjct: 192 IKKYTTLSYRAPEMVNLYSGKIITTKADIWAL 223 >6G4J-A nrPDB Length = 315 Score = 29.7 bits (65), Expect = 1.2, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 23/53 (43%), Gaps = 2/53 (3%) Query: 132 DPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFG 184 D ++ + + ++ + +LH + GDL N+++ G ID G Sbjct: 119 DKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVT--GPPARIRCIDVG 169 >3J7A-H nrPDB Length = 306 Score = 29.7 bits (65), Expect = 1.3, Method: Composition-based stats. Identities = 36/195 (18%), Positives = 66/195 (33%), Gaps = 13/195 (6%) Query: 64 IDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLK 123 ++ +E +LL + G VP + + G+++ G D G + Sbjct: 9 LNNVQKSIEIDDEKKLLPFMEKRIGNAVPGDSIGEEFTGYVFRITGGNDKQGFPMIQGVL 68 Query: 124 NFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDF 183 + RK G + DL++ N+ LV+ G P L D Sbjct: 69 TNNRVRLLFKKGMKCYRP-RKKGERKRKSVRGCIVGQDLSALNLTLVKKGVNEIPGLTDK 127 Query: 184 GLGS------------VSNLVEDKGVDLYVLERAILSTHSKHAEKYNAWIMEGFEEVYRE 231 +G + NL + V YV+ RAI K + + + R+ Sbjct: 128 AVGKKLGPKRASKIRKLFNLDKSDDVRKYVIGRAITKNGKTKFIKPKIQRLVTEKRLLRK 187 Query: 232 QGAKGAKKLKEVTKR 246 + AK+ + + K+ Sbjct: 188 RNLLQAKEKRRLEKK 202 >4XLV-A nrPDB Length = 328 Score = 29.7 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 21/44 (47%), Gaps = 3/44 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 ++ + L+ + H DL + N ++ D +T + DFG+ Sbjct: 160 EIADGMAYLNAKKFVHRDLAARNCMVAHD---FTVKIGDFGMTR 200 >3LLT-A nrPDB Length = 360 Score = 29.0 bits (63), Expect = 2.2, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 52/156 (33%), Gaps = 30/156 (19%) Query: 57 KRYRHPQIDQALTK-HRTLN-ESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGEDL- 113 K+Y ++ + + K R+ E+ +L K+ + + + + + E L Sbjct: 60 KKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPLG 119 Query: 114 PGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLV--- 170 P + N+ H +D + + + + L H DL NI+L Sbjct: 120 PSLYEIITRNNYNGFHIEDIKLYCIE-----ILKALNYLRKMSLTHTDLKPENILLDDPY 174 Query: 171 -----------RDGARWTPH--------LIDFGLGS 187 DG + + LIDFG + Sbjct: 175 FEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT 210 >4OAU-C nrPDB Length = 699 Score = 29.0 bits (63), Expect = 2.2, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 24/59 (40%), Gaps = 5/59 (8%) Query: 127 WMHDQDPYSDLVATT-LRKVGRQIGLLHWN-DYCHGDLTSSNIVLVRDGARWTPHLIDF 183 D + D A L + + + LH + Y H DL NI++ A HL DF Sbjct: 429 RGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAA---HLADF 484 >3G0E-A nrPDB Length = 336 Score = 28.6 bits (62), Expect = 2.6, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 21/54 (38%), Gaps = 3/54 (5%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVSNLVEDKGV 197 +V + + L + H DL + NI+L + DFGL + V Sbjct: 176 QVAKGMAFLASKNCIHRDLAARNILL---THGRITKICDFGLARDIKNDSNYVV 226 >6GQK-A nrPDB Length = 328 Score = 28.6 bits (62), Expect = 3.3, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 19/44 (43%), Gaps = 3/44 (6%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 +V + + L + H DL + NI+L + DFGL Sbjct: 169 QVAKGMAFLASKNCIHRDLAARNILLTHGNIT---KICDFGLAR 209 >4MLQ-A nrPDB Length = 312 Score = 28.2 bits (61), Expect = 4.0, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 17/33 (51%) Query: 7 DKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYL 39 D V+ YL P++ + + QGA AI H L Sbjct: 182 DTVTQYLEPEISVPAVGQGALAIECRENDHELL 214 >3Q9T-A nrPDB Length = 577 Score = 27.8 bits (60), Expect = 4.8, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 58/192 (30%), Gaps = 31/192 (16%) Query: 17 VDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNE 76 V I G + TT ++S + K +R + +I++ T+ +TL Sbjct: 33 VLIVEAGIGNPEDIPEITTPSSAMDLRNSKYDWAYKTTMVRRDDYERIEKPNTRGKTLGG 92 Query: 77 SRLLAKLYLIPGLCV-------------------PQLIA--CDPYNGFIW---LEFLGE- 111 S L +PG P L + ++ LE +G Sbjct: 93 SSSLNYFTWVPGHKATFDQWEEFGGKEWTWDPLVPYLRKSATYHDDPRLYSPELEKIGGG 152 Query: 112 ---DLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKV--GRQIGLLHWNDYCHGDLTSSN 166 + + F + + + + + G GL H D + S + Sbjct: 153 GPIPISHAELIDEMAPF-RENLTKAWKSMGQPLIENIYDGEMDGLTHCCDTIYRGQRSGS 211 Query: 167 IVLVRDGARWTP 178 + V++ T Sbjct: 212 FLFVKNKPNITI 223 >2ZIG-A nrPDB Length = 297 Score = 27.8 bits (60), Expect = 4.9, Method: Composition-based stats. Identities = 21/85 (24%), Positives = 33/85 (38%), Gaps = 9/85 (10%) Query: 37 PYLPRAK-DSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNES--RLLAKLYLI-PG---L 89 PY P A + +YI+ R P YR P +Q K R E R +++ PG Sbjct: 156 PYEPGAIIKTEIEYILMQRKPGGYRKPTQEQRE-KSRLPKEDFHRFFRQIWDDIPGESTK 214 Query: 90 CVPQLIACDPYNGFI-WLEFLGEDL 113 P + + F+G+ + Sbjct: 215 DHPAPFPLELAERLVRMFSFVGDVV 239 >3ZZW-A nrPDB Length = 289 Score = 27.8 bits (60), Expect = 5.0, Method: Composition-based stats. Identities = 8/42 (19%), Positives = 17/42 (40%), Gaps = 3/42 (7%) Query: 144 KVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 ++ + L + H DL + N+++ + D GL Sbjct: 136 QIAAGMEYLSSHHVVHKDLATRNVLVYDK---LNVKISDLGL 174 >4LIV-A nrPDB Length = 407 Score = 27.4 bits (59), Expect = 5.8, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 22/60 (36%), Gaps = 3/60 (5%) Query: 48 KYIIKYRPPKRYRHPQIDQA---LTKHRTLNESRLLAKLYLIPGLCVPQLIACDPYNGFI 104 +I + P P +DQ + + R+ KL + P L+ DP+ I Sbjct: 144 DLMISFSVPGGGVGPHLDQYDVFIIQGTGRRRWRVGEKLQMKQHCPHPDLLQVDPFEAII 203 >2JD5-A nrPDB Length = 373 Score = 27.4 bits (59), Expect = 6.9, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 17/51 (33%), Gaps = 4/51 (7%) Query: 138 VATTLRKVGRQIGLLHWN-DYCHGDLTSSNIVL---VRDGARWTPHLIDFG 184 V +++ + +H H D+ N+++ + D G Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLG 183 >1ZP9-A nrPDB Length = 258 Score = 27.0 bits (58), Expect = 7.6, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 45/132 (34%), Gaps = 20/132 (15%) Query: 59 YRHPQIDQALTKHR------TLNESRLLAKLYLIPGLCVPQLIACDPYNGFIWLEFLGED 112 Y + D + T E R L + G+ VPQ + +EF+GED Sbjct: 97 YGDERFDMRRISPKEKVFIWTEKEFRNL-ERAKEAGVSVPQPYTY--MKNVLLMEFIGED 153 Query: 113 LPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRD 172 L L D + + V +++ L + H DL+ NI+ + Sbjct: 154 ELPAPTLVELGRELKELDVEGIFNDVVENVKR------LYQEAELVHADLSEYNIMYIDK 207 Query: 173 GARWTPHLIDFG 184 + ID G Sbjct: 208 -----VYFIDMG 214 >5USZ-A nrPDB Length = 289 Score = 27.0 bits (58), Expect = 8.2, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 30/67 (44%), Gaps = 11/67 (16%) Query: 143 RKVGRQIGLLHWNDYCHGDLTSSNIVLVR--DGARWTPHLIDFGLGSVSNLVEDKGVDLY 200 +++ + L N HG++ + NI+L+R D P I + D G+ + Sbjct: 120 KQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFI---------KLSDPGISIT 170 Query: 201 VLERAIL 207 VL + IL Sbjct: 171 VLPKDIL 177 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.317 0.127 0.319 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 9,521,506 Number of Sequences: 36641 Number of extensions: 366402 Number of successful extensions: 1693 Number of sequences better than 10.0: 438 Number of HSP's better than 10.0 without gapping: 332 Number of HSP's successfully gapped in prelim test: 171 Number of HSP's that attempted gapping in prelim test: 1235 Number of HSP's gapped (non-prelim): 507 length of query: 261 length of database: 10,336,785 effective HSP length: 95 effective length of query: 166 effective length of database: 6,855,890 effective search space: 1138077740 effective search space used: 1138077740 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 58 (27.0 bits)