BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P53011 (349 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3F3P-A nrPDB 719 0.0 5A9Q-7 nrPDB 206 2e-53 4YCZ-A nrPDB 130 1e-30 3BG0-A nrPDB 125 3e-29 4L9O-A nrPDB 110 1e-24 4BZK-B nrPDB 99 2e-21 3JRP-A nrPDB 99 2e-21 3JRO-A nrPDB 97 8e-21 2HES-X nrPDB 63 2e-10 3FM0-A nrPDB 60 2e-09 6EOJ-D nrPDB 48 5e-06 1VYH-C nrPDB 48 6e-06 4BTS-AR nrPDB 46 2e-05 5FL8-q nrPDB 44 9e-05 3DM0-A nrPDB 44 9e-05 6QX9-5O nrPDB 44 1e-04 6HQA-B nrPDB 40 0.001 5OQL-J nrPDB 40 0.001 5MZH-A nrPDB 40 0.002 5GAN-H nrPDB 40 0.002 5WLC-LO nrPDB 40 0.002 5I2T-A nrPDB 40 0.002 5NNZ-B nrPDB 40 0.002 5K1B-B nrPDB 39 0.002 1NR0-A nrPDB 39 0.003 6QX9-4B nrPDB 39 0.003 6MZM-G nrPDB 38 0.005 6GMH-W nrPDB 38 0.008 6F3T-A nrPDB 37 0.010 4A11-B nrPDB 37 0.011 6F1U-h nrPDB 37 0.014 5MC6-j nrPDB 36 0.024 6HHQ-h nrPDB 36 0.024 4V8M-A7 nrPDB 36 0.024 5CXB-B nrPDB 36 0.028 5WYK-BB nrPDB 36 0.032 4XFV-A nrPDB 35 0.042 4V6W-Ag nrPDB 35 0.055 5WYJ-BC nrPDB 35 0.058 5N4A-A nrPDB 35 0.058 5FA5-B nrPDB 34 0.089 3JAP-g nrPDB 34 0.098 6G51-g nrPDB 33 0.13 3DWL-C nrPDB 33 0.13 5OPT-p nrPDB 33 0.14 5NZU-C nrPDB 33 0.18 4UII-A nrPDB 33 0.19 4V7E-Bg nrPDB 33 0.20 4OWR-A nrPDB 33 0.21 5WJC-A nrPDB 33 0.21 3ACP-A nrPDB 33 0.23 5Z56-q nrPDB 33 0.25 3W15-A nrPDB 33 0.26 5OQL-d nrPDB 32 0.32 5LE5-B nrPDB 32 0.43 4LG8-A nrPDB 32 0.46 5WLC-LS nrPDB 32 0.50 6EM1-m nrPDB 32 0.50 5G04-R nrPDB 32 0.56 3OC5-A nrPDB 32 0.59 6C0F-s nrPDB 32 0.60 3JB9-g nrPDB 31 0.65 2P9P-C nrPDB 31 0.68 3CFV-B nrPDB 31 0.69 5M25-A nrPDB 31 0.69 4GGA-A nrPDB 31 0.72 6CB1-s nrPDB 31 0.77 5LCW-Q nrPDB 31 0.86 2H9P-A nrPDB 31 0.87 5OQL-L nrPDB 31 0.98 3C9C-A nrPDB 30 1.1 5Y1U-A nrPDB 30 1.1 4N14-A nrPDB 30 1.2 3MKQ-A nrPDB 30 1.2 1PIE-A nrPDB 30 1.2 3T8I-A nrPDB 30 1.3 6ELZ-p nrPDB 30 1.6 6Q8F-A nrPDB 30 1.6 2YNP-A nrPDB 30 1.6 5OV3-A nrPDB 30 1.7 5OQL-X nrPDB 30 1.8 5XYI-g nrPDB 30 1.9 5Y88-O nrPDB 30 2.2 5WYJ-BE nrPDB 30 2.2 6J6H-n nrPDB 29 2.4 5YZG-W nrPDB 29 2.8 6QDV-o nrPDB 29 2.9 3FCP-A nrPDB 29 3.2 5CXC-A nrPDB 29 3.4 3ODT-A nrPDB 29 3.9 5TF2-A nrPDB 28 4.5 5BJS-A nrPDB 28 4.7 4JBD-A nrPDB 28 5.1 5WLC-LU nrPDB 28 5.2 5WLC-LJ nrPDB 28 6.1 5M89-A nrPDB 28 6.2 4AEZ-A nrPDB 28 6.5 6EMK-B nrPDB 28 8.7 3I2N-A nrPDB 27 8.9 5MSH-B nrPDB 27 9.2 >3F3P-A nrPDB Length = 351 Score = 719 bits (1857), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/349 (100%), Positives = 349/349 (100%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI Sbjct: 183 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 242 Query: 241 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 300 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH Sbjct: 243 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 302 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ Sbjct: 303 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 351 >5A9Q-7 nrPDB Length = 360 Score = 206 bits (523), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 122/351 (34%), Positives = 195/351 (55%), Gaps = 55/351 (15%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H DL+HDV +DF+GR +ATCSSDQ +KV+ ++ +W + SW+ H S+ + WA PE Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 68 YGRIIASASYDKTVKLWEE--DPDQEECSGR-RWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 +G+++AS S+D+T +WEE ++ G+ W K TL DS+ S+ VKFAP H+GL Sbjct: 70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLM 129 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP--SRFSPEK 182 LA DGI+R+Y+A + +L W+L E+ S C+SW P SR Sbjct: 130 LATCSADGIVRIYEAPDVMNLSQWSLQHEISC--------KLSCSCISWNPSSSRAHSPM 181 Query: 183 LAV-------SALEQAIIYQRGKDGKLHVAAK-LPGHKSLIRSISWAPSIGRWYQLIATG 234 +AV +A+ + I++ ++ + + A+ L + I++AP++GR + ++A Sbjct: 182 IAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIA 241 Query: 235 CKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQV 294 KD +RIF L P+ E LT+S + ++ Sbjct: 242 TKD--VRIF----TLKPVRKE--LTSSGG-------------------------PTKFEI 268 Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 ++++ D+HN +VW VSWN+TGT+L+S+GDDG VRLWKA Y + +KC ++ Sbjct: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319 >4YCZ-A nrPDB Length = 876 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 104/359 (28%), Positives = 165/359 (45%), Gaps = 84/359 (23%) Query: 5 DSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 +SGHDD++HD V D+YGR +ATCSSD+ IK+F+++ +T L+++ + HD ++ + WA Sbjct: 14 NSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQ--RLTETLKGHDGAVWCVSWA 71 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 P+YG I+ASA YD V +W E +G W ++ K S+ V ++P G Sbjct: 72 HPKYGNILASAGYDGKVLIW------RELNG-AWQRIFDFALHKASVNVVSWSPHEAGCL 124 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 LAC +DG + + LE D SW SI A+ L + +SW P+ SP + Sbjct: 125 LACASSDGNVSV---LEFRD-NSWE-------HSIFHAHGLGVN-SVSWAPAT-SPGSIV 171 Query: 185 VSALEQAIIYQR-----GKDGKLHVAA-------------KLPGHKSLIRSISWAPSIGR 226 S R G D L + A L GH +R ++W+P++ + Sbjct: 172 SSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQ 231 Query: 227 WYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA 286 IA+ +D +RI+ ++ Sbjct: 232 -KSYIASASEDRTVRIW-------------------------------------TSDPAN 253 Query: 287 ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 LQ N +V + + VW VSW+L+G +L+++G D KV LWK E++C+ I Sbjct: 254 PLQWNCKVL------NFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTI 306 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 8/87 (9%) Query: 253 ASEESLTNSNMFDNSADVDMDAQGR-----SDSNTEEKAELQSNLQVELLSEHDDHNGEV 307 A + + NS D D +D GR S T + E++ Q L H+G V Sbjct: 7 AGTQVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQ-RLTETLKGHDGAV 65 Query: 308 WSVSWNLT--GTILSSAGDDGKVRLWK 332 W VSW G IL+SAG DGKV +W+ Sbjct: 66 WCVSWAHPKYGNILASAGYDGKVLIWR 92 >3BG0-A nrPDB Length = 316 Score = 125 bits (313), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 99/364 (27%), Positives = 163/364 (44%), Gaps = 76/364 (20%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 + D+ H+D++HD D+YG +ATCSSD+ +K+F + ++ ++D R H+ + Sbjct: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDV-RNGGQILIADL-RGHEGPVWQ 62 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + WA P YG I+AS SYD+ V +W E+ W K S+ SV +AP Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREE-------NGTWEKSHEHAGHDSSVNSVCWAPHD 115 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 GL LAC +DG + L ++T + +V I A+ + + +SW P+ Sbjct: 116 YGLILACGSSDGAISLL---------TYTGEGQWEVKKINNAHTIGCN-AVSWAPAVVPG 165 Query: 181 --------------EKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 225 ++ A + I +++ +DG+ KL H +R ++WAPSIG Sbjct: 166 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 IA+ +DGR+ I+ + + SNT Sbjct: 226 LPTSTIASCSQDGRVFIWTCDD------------------------------ASSNT--- 252 Query: 286 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 +LL + +D VW VSW++T IL+ +G D KV LWK + ++ C+S + Sbjct: 253 ------WSPKLLHKFND---VVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDV 303 Query: 346 TAQQ 349 Q Sbjct: 304 NKGQ 307 >4L9O-A nrPDB Length = 349 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 93/345 (26%), Positives = 148/345 (42%), Gaps = 78/345 (22%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 + HDDL+HD V D+YGR +ATCSSD+ IK+F++D + N L ++ H+ + + WA Sbjct: 66 NAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGE--NQRLVETLIGHEGPVWQVAWAH 123 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 P++G I+AS SYD V +W+ED WNK+ + + S+ SV +AP G L Sbjct: 124 PKFGVILASCSYDGKVLIWKED-------NGVWNKVAEHSVHQASVNSVSWAPHEYGPVL 176 Query: 126 ACLGNDGILRLYD-----ALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF-- 178 C +DG + + + ALEP I H SW P Sbjct: 177 LCASSDGKISIVEFKDGGALEP----------------IVIQGHAIGVNAASWAPISLPD 220 Query: 179 SPEKLAVSALEQAI-IYQRGKDGKLHVAAK-LPGHKSLIRSISWAPS-IGRWYQLIATGC 235 + + + + I++ K + + GH +R ++W+PS + + Y IAT Sbjct: 221 NTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSY--IATAS 278 Query: 236 KDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 295 +D + I+ K SN EK L + Sbjct: 279 QDRTVLIWTKDGK-------------------------------SNKWEKQPLTKEKFPD 307 Query: 296 LLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 340 + W SW+L+G +L+ +G D KV LWK +++ Sbjct: 308 VC----------WRASWSLSGNVLAISGGDNKVTLWKENIQGKWE 342 >4BZK-B nrPDB Length = 297 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 116/236 (49%), Gaps = 32/236 (13%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETH--KLIDTLTGHEGPVWR 58 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 111 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L +DG + + + E TS + + + H SW P+ Sbjct: 112 YGPLLLVASSDGKVSVVEFKENG------TTSPIIIDA-----HAIGVNSASWAPATIEE 160 Query: 181 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSI 224 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 62/290 (21%), Positives = 123/290 (42%), Gaps = 36/290 (12%) Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 YG+ +A+ S DKT+K++E + + + + TL +G ++ V +A G LA Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETHKL-------IDTLTGHEGPVWRVDWAHPKFGTILAS 72 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 DG + ++ + W S++ V ++ H S + W P + P L S+ Sbjct: 73 CSYDGKVLIWK----EENGRW---SQIAVHAV----HSASVNSVQWAPHEYGPLLLVASS 121 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSI---------GRWYQLIATGCKDG 238 + + + ++G + H + S SWAP+ + + TG D Sbjct: 122 DGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 239 RIRIFKITEKLSPLASEESLTNSN--MFDNSADVDMDAQGRSDSNTEEKAEL---QSNLQ 293 ++I+K E +L + + D + + + S ++++ + Q N Q Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 294 ---VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 340 + L + + +W SW+L+G +L+ +G D KV LWK +++ Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWE 290 Score = 32.0 bits (71), Expect = 0.39, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGR-IIASASYDKT 80 R T +D +K++K + D + L + H + + W+ R +AS S D+T Sbjct: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 Query: 81 VKLWEEDPDQ 90 +W +D +Q Sbjct: 231 CIIWTQDNEQ 240 >3JRP-A nrPDB Length = 379 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 116/236 (49%), Gaps = 32/236 (13%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 3 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETH--KLIDTLTGHEGPVWR 60 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 113 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L +DG + + + E TS + + + H SW P+ Sbjct: 114 YGPLLLVASSDGKVSVVEFKENG------TTSPIIIDA-----HAIGVNSASWAPATIEE 162 Query: 181 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSI 224 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 163 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 218 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/282 (22%), Positives = 118/282 (41%), Gaps = 36/282 (12%) Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 YG+ +A+ S DKT+K++E G + TL +G ++ V +A G LA Sbjct: 22 YGKRLATCSSDKTIKIFE-------VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILAS 74 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 DG + ++ + W S++ V ++ H S + W P + P L S+ Sbjct: 75 CSYDGKVLIWK----EENGRW---SQIAVHAV----HSASVNSVQWAPHEYGPLLLVASS 123 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSI---------GRWYQLIATGCKDG 238 + + + ++G + H + S SWAP+ + + TG D Sbjct: 124 DGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 182 Query: 239 RIRIFKITEKLSPLASEESLTNSN--MFDNSADVDMDAQGRSDSNTEEKAEL---QSNLQ 293 ++I+K E +L + + D + + + S ++++ + Q N Q Sbjct: 183 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 242 Query: 294 ---VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 + L + + +W SW+L+G +L+ +G D KV LWK Sbjct: 243 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGR-IIASASYDKT 80 R T +D +K++K + D + L + H + + W+ R +AS S D+T Sbjct: 173 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 232 Query: 81 VKLWEEDPDQ 90 +W +D +Q Sbjct: 233 CIIWTQDNEQ 242 >3JRO-A nrPDB Length = 753 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 115/236 (48%), Gaps = 32/236 (13%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETH--KLIDTLTGHEGPVWR 58 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 111 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L +DG + + + E + + + + A SW P+ Sbjct: 112 YGPLLLVASSDGKVSVVEFKENGTTSP--IIIDAHAIGVNSA---------SWAPATIEE 160 Query: 181 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSI 224 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV 216 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 63/282 (22%), Positives = 118/282 (41%), Gaps = 36/282 (12%) Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 YG+ +A+ S DKT+K++E G + TL +G ++ V +A G LA Sbjct: 20 YGKRLATCSSDKTIKIFE-------VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILAS 72 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 DG + ++ + W S++ V ++ H S + W P + P L S+ Sbjct: 73 CSYDGKVLIW----KEENGRW---SQIAVHAV----HSASVNSVQWAPHEYGPLLLVASS 121 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSI---------GRWYQLIATGCKDG 238 + + + ++G + H + S SWAP+ + + TG D Sbjct: 122 DGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADN 180 Query: 239 RIRIFKITEKLSPLASEESLTNSN--MFDNSADVDMDAQGRSDSNTEEKAEL---QSNLQ 293 ++I+K E +L + + D + + + S ++++ + Q N Q Sbjct: 181 LVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQ 240 Query: 294 ---VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 + L + + +W SW+L+G +L+ +G D KV LWK Sbjct: 241 GPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 1/70 (1%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGR-IIASASYDKT 80 R T +D +K++K + D + L + H + + W+ R +AS S D+T Sbjct: 171 RKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT 230 Query: 81 VKLWEEDPDQ 90 +W +D +Q Sbjct: 231 CIIWTQDNEQ 240 >2HES-X nrPDB Length = 330 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 110/243 (45%), Gaps = 25/243 (10%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH++ V V + G ++ATCS D+ + +++ D+ +E + H + + W Sbjct: 105 GHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPS 164 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 E ++AS+SYD TV++W++ D EC + LN +G+++S F +L Sbjct: 165 E--ALLASSSYDDTVRIWKDYDDDWEC-------VAVLNGHEGTVWSSDFDKTEGVFRLC 215 Query: 127 CLGNDGILRLYDAL--EPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 +D +R++ + + D + W +I P H + + ++W F+ + Sbjct: 216 SGSDDSTVRVWKYMGDDEDDQQEWVCE------AILPDVHKRQVYNVAW---GFNGLIAS 266 Query: 185 VSALEQAIIYQRGKDGKLHVAAK--LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 V A +Y+ DG+ V AK L I + W G+ ++ATG DG + Sbjct: 267 VGADGVLAVYEE-VDGEWKVFAKRALCHGVYEINVVKWLELNGK--TILATGGDDGIVNF 323 Query: 243 FKI 245 + + Sbjct: 324 WSL 326 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 30/157 (19%) Query: 209 PGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSA 268 HK IRS++W P L+A G D + I+ A EES + D A Sbjct: 55 TAHKKAIRSVAWRPHT----SLLAAGSFDSTVSIW---------AKEESADRTFEMDLLA 101 Query: 269 DVD---MDAQGRSDSN--------TEEKAEL-----QSNLQVELLSEHDDHNGEVWSVSW 312 ++ + +G + SN + +K+ +S + E +S +H+ +V V W Sbjct: 102 IIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIW 161 Query: 313 NLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 + + +L+S+ D VR+WK Y ++++C++V+ + Sbjct: 162 HPSEALLASSSYDDTVRIWK-DYDDDWECVAVLNGHE 197 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 104/236 (44%), Gaps = 27/236 (11%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 K ++ SV + P H L LA D + ++ E +D T EM +L+I H Sbjct: 58 KKAIRSVAWRP-HTSL-LAAGSFDSTVSIWAKEESADR-----TFEMDLLAIIEG-HENE 109 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKLH-VAAKLPGHKSLIRSISWAPSIG 225 ++W + LA + ++++ I++ + G+ + + L H ++ + W PS Sbjct: 110 VKGVAWSNDGY---YLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPS-- 164 Query: 226 RWYQLIATGCKDGRIRIFKIT----EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 281 L+A+ D +RI+K E ++ L E S+ FD + V G DS Sbjct: 165 --EALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDST 222 Query: 282 TEEKAEL--QSNLQVELLSEH---DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 + + Q E + E D H +V++V+W G +++S G DG + +++ Sbjct: 223 VRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYE 277 >3FM0-A nrPDB Length = 345 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 77/328 (23%), Positives = 120/328 (36%), Gaps = 100/328 (30%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH++ V V + G +ATCS D+ + V+++D++ +E +H + + W Sbjct: 103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE-DEYECVSVLNSHTQDVKHVVWHPS 161 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + ++ASASYD TVKL+ E+ D C TL + +++S+ F P+ G +LA Sbjct: 162 Q--ELLASASYDDTVKLYREEEDDWVCCA-------TLEGHESTVWSLAFDPS--GQRLA 210 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +D +R++ P + Sbjct: 211 SCSDDRTVRIWRQYLPGN------------------------------------------ 228 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPG-HKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 EQ + G D L G H I I+W G +AT C D IR+F+ Sbjct: 229 --EQGVACS-GSDPSWKCICTLSGFHSRTIYDIAWCQLTG----ALATACGDDAIRVFQE 281 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNG 305 P SLT A L H H+ Sbjct: 282 DPNSDPQQPTFSLT--------------------------AHL-----------HQAHSQ 304 Query: 306 EVWSVSWNLTGT-ILSSAGDDGKVRLWK 332 +V V+WN +L+S DDG+V WK Sbjct: 305 DVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 108/237 (45%), Gaps = 43/237 (18%) Query: 15 VVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSW-------RAHDSSIVAIDWASPE 67 + ++ G +A+C D+ I+++ + DSW H ++ + W SP Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTE--------GDSWICKSVLSEGHQRTVRKVAW-SP- 71 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 G +ASAS+D T +W+++ D EC + TL + + SV +AP+ G LA Sbjct: 72 CGNYLASASFDATTCIWKKNQDDFEC-------VTTLEGHENEVKSVAWAPS--GNLLAT 122 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 D + +++ E + + VL+ +H Q + W PS+ E LA ++ Sbjct: 123 CSRDKSVWVWEVDEEDEYEC------VSVLN----SHTQDVKHVVWHPSQ---ELLASAS 169 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 + + R ++ A L GH+S + S+++ PS R +A+ D +RI++ Sbjct: 170 YDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR----LASCSDDRTVRIWR 222 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 59/247 (23%), Positives = 102/247 (41%), Gaps = 48/247 (19%) Query: 108 KGSLYSVKFAPAH------------LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMK 155 K SL + PAH G LA G D +R++ ++ SW S Sbjct: 2 KDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWG----TEGDSWICKS--- 54 Query: 156 VLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLI 215 VLS H ++ ++W P LA ++ + + L GH++ + Sbjct: 55 VLS---EGHQRTVRKVAWSPCG---NYLASASFDATTCIWKKNQDDFECVTTLEGHENEV 108 Query: 216 RSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQ 275 +S++WAPS L+AT +D + ++++ E+ +E S + ++ DV Sbjct: 109 KSVAWAPS----GNLLATCSRDKSVWVWEVDEE------DEYECVSVLNSHTQDVKHVVW 158 Query: 276 GRSDSNTEEKAELQSNLQVELLSEHDD----------HNGEVWSVSWNLTGTILSSAGDD 325 S E A + V+L E +D H VWS++++ +G L+S DD Sbjct: 159 HPSQ---ELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215 Query: 326 GKVRLWK 332 VR+W+ Sbjct: 216 RTVRIWR 222 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 32/54 (59%) Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQ 348 E ++ + H EV SV+W +G +L++ D V +W+ +E++C+SV+ + Sbjct: 96 ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH 149 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 304 NGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVIT 346 + W ++WN GT+L+S G D ++R+W T + + C SV++ Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIW-GTEGDSWICKSVLS 57 >6EOJ-D nrPDB Length = 470 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 106/261 (40%), Gaps = 40/261 (15%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 D+ H + + D+ + TCS D +K++ SN + H + + DW Sbjct: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF----SNGKQERVLSGHHWDVKSCDW 227 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 PE G +IASAS D VKLW DP C + ++ K ++ +F P L Sbjct: 228 -HPEMG-LIASASKDNLVKLW--DPRSGNC-------ISSILKFKHTVLKTRFQPTKGNL 276 Query: 124 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDF-CLSWCPSRFSPEK 182 +A + D R++D +++ M V ++D+ L W P S Sbjct: 277 LMA-ISKDKSCRVFDI-------RYSMKELMCVRD-------ETDYMTLEWHPINESMFT 321 Query: 183 LAV--SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 LA +L+ + Q + L + H I S+S+ P +G + AT KD I Sbjct: 322 LACYDGSLKHFDLLQNLNEPILTIPY---AHDKCITSLSYNP-VG---HIFATAAKDRTI 374 Query: 241 RIFKITEKLSPLASEESLTNS 261 R + + P A ++ N+ Sbjct: 375 RFWTRARPIDPNAYDDPTYNN 395 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 24/45 (53%) Query: 287 ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 +L NL +L+ H+ + S+S+N G I ++A D +R W Sbjct: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 >1VYH-C nrPDB Length = 410 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 29/79 (36%), Positives = 45/79 (56%), Gaps = 6/79 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D V D+ +D G+ +A+CS+D IK++ D +E + HD ++ ++ P Sbjct: 148 GHTDSVQDISFDHSGKLLASCSADMTIKLW----DFQGFECIRTMHGHDHNVSSVS-IMP 202 Query: 67 EYGRIIASASYDKTVKLWE 85 G I SAS DKT+K+WE Sbjct: 203 N-GDHIVSASRDKTIKMWE 220 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 43/79 (54%), Gaps = 6/79 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GHD+ V V++ G+ + +C+ D+ ++V+ D N + AH+ + ++D+ Sbjct: 336 GHDNWVRGVLFHSGGKFILSCADDKTLRVW----DYKNKRCMKTLNAHEHFVTSLDFH-- 389 Query: 67 EYGRIIASASYDKTVKLWE 85 + + + S D+TVK+WE Sbjct: 390 KTAPYVVTGSVDQTVKVWE 408 Score = 34.3 bits (77), Expect = 0.079, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 43/98 (43%), Gaps = 22/98 (22%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA- 64 +GH + V V + G +A+CS+DQ ++V+ + EL R H + I WA Sbjct: 231 TGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL----REHRHVVECISWAP 286 Query: 65 -----------------SPEYGRIIASASYDKTVKLWE 85 S + G + S S DKT+K+W+ Sbjct: 287 ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324 >4BTS-AR nrPDB Length = 343 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 76/348 (21%), Positives = 141/348 (40%), Gaps = 57/348 (16%) Query: 7 GHDDLVHDVVYDFYGRH------VATCSSDQHIKVFKLDKDTSNWELSDSWRA---HDSS 57 GH D V +V F + + + S D+ + ++KL ++ N +A H+ Sbjct: 19 GHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHF 78 Query: 58 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA 117 + D A + S+S+DKT++LW+ +G + + + +YSV F+ Sbjct: 79 VS--DLALSQENCFAISSSWDKTLRLWDLR------TGTTYKRFV---GHQSEVYSVAFS 127 Query: 118 PAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSR 177 P + ++ A +++ W + E K S NH C+ + P Sbjct: 128 PDN-------------RQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIM 174 Query: 178 FSPEKLAVSALEQAIIYQRGKDGKLHV-------AAKLPGHKSLIRSISWAPSIGRWYQL 230 S K+ A A + G DG+L V H+S + +S +P+ G++ Sbjct: 175 KSANKVQPFAPYFASV---GWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPN-GKY--- 227 Query: 231 IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS------NTEE 284 IATG KD ++ I+ I P ++ + N + + A G T+ Sbjct: 228 IATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQS 287 Query: 285 KAELQSNLQVELLSEHDDHNG---EVWSVSWNLTGTILSSAGDDGKVR 329 KA + ++ E +++ + G + S++WN G L + DG +R Sbjct: 288 KAPV-CTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIR 334 >5FL8-q nrPDB Length = 515 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 79/379 (20%), Positives = 145/379 (38%), Gaps = 95/379 (25%) Query: 24 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 83 + T + D +++ D T L + H + ++ + W SP+ G +IA+ S D T++L Sbjct: 159 MVTGAGDNTARIWDCDTQTPMHTL----KGHYNWVLCVSW-SPD-GEVIATGSMDNTIRL 212 Query: 84 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL-----GLKLACLGNDGILRLYD 138 W DP +C G L + S+ + P HL +LA DG ++++D Sbjct: 213 W--DPKSGQCLGD------ALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWD 264 Query: 139 AL------------------------------EPSDLRSWTLTSEMKVLSIPPA-----N 163 + +R W + S+ + ++I + N Sbjct: 265 TVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVN 324 Query: 164 H--LQSDFCLSWC--------PSRFSPEKLAVSALE--QAIIYQRGKDGKLHVA------ 205 H L +D+ L PS +PE+ ALE + I + G ++ V Sbjct: 325 HLSLSTDYALRIGAFDHTGKKPS--TPEEAQKKALENYEKICKKNGNSEEMMVTASDDYT 382 Query: 206 -------------AKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL 252 A++ GH+ L+ ++++P GR+ I + D I+++ + Sbjct: 383 MFLWNPLKSTKPIARMTGHQKLVNHVAFSPD-GRY---IVSASFDNSIKLWDGRDGKFIS 438 Query: 253 ASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW 312 + + S+D + D+ + L V+L H EV++V W Sbjct: 439 TFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDL----PGHKDEVYTVDW 494 Query: 313 NLTGTILSSAGDDGKVRLW 331 ++ G + S G D VRLW Sbjct: 495 SVDGKRVCSGGKDKMVRLW 513 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 66/133 (49%), Gaps = 19/133 (14%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH LV+ V + GR++ + S D IK++ D + + ++R H +S+ + W+S Sbjct: 399 TGHQKLVNHVAFSPDGRYIVSASFDNSIKLW----DGRDGKFISTFRGHVASVYQVAWSS 454 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCT-LNDSKGSLYSVKFAPAHLGLK 124 R++ S S D T+K+W+ R KL L K +Y+V ++ G + Sbjct: 455 D--CRLLVSCSKDTTLKVWDV----------RTRKLSVDLPGHKDEVYTVDWSVD--GKR 500 Query: 125 LACLGNDGILRLY 137 + G D ++RL+ Sbjct: 501 VCSGGKDKMVRLW 513 >3DM0-A nrPDB Length = 694 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 66/158 (41%), Gaps = 12/158 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V V + R + + S D+ IK++ + + +S+ H + + ++ Sbjct: 470 GHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGEC-KYTISEGGEGHRDWVSCVRFSPN 528 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 I SAS+DKTVK+W + C R TL G + +V +P G A Sbjct: 529 TLQPTIVSASWDKTVKVW----NLSNCKLR-----STLAGHTGYVSTVAVSPD--GSLCA 577 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANH 164 G DG++ L+D E L S S + L P + Sbjct: 578 SGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPNRY 615 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V DVV G+ + S D ++++ L S + + H ++++ ++ Sbjct: 427 TGHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVS----TRRFVGHTKDVLSVAFSL 482 Query: 66 PEYGRIIASASYDKTVKLW 84 R I SAS D+T+KLW Sbjct: 483 DN--RQIVSASRDRTIKLW 499 Score = 27.7 bits (60), Expect = 6.9, Method: Compositional matrix adjust. Identities = 67/326 (20%), Positives = 124/326 (38%), Gaps = 51/326 (15%) Query: 47 LSDSWRAHDSSIVAIDWASP-EYGRIIASASYDKTVKLWEEDPD-------QEECSGRR- 97 L + RAH + AI A+P + II SAS DK++ LW+ D Q +G Sbjct: 374 LKGTMRAHTDMVTAI--ATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSH 431 Query: 98 ------------------WNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 139 W+ L D + + +F H L+ + ++ A Sbjct: 432 FVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFV-GHTKDVLSVAFSLDNRQIVSA 490 Query: 140 LEPSDLRSWTLTSEMK-VLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGK 198 ++ W E K +S H C+ + P+ P ++ S + ++ Sbjct: 491 SRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN 550 Query: 199 DGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE--KLSPLASEE 256 + + L GH + +++ +P L A+G KDG + ++ + E KL L + Sbjct: 551 ---CKLRSTLAGHTGYVSTVAVSPD----GSLCASGGKDGVVLLWDLAEGKKLYSLEANS 603 Query: 257 SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHD--DHNGEV------- 307 + N + + E + +L+V+L +E + D++G Sbjct: 604 VIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVI 663 Query: 308 --WSVSWNLTGTILSSAGDDGKVRLW 331 S++W+ G+ L S DG +R+W Sbjct: 664 YCTSLNWSADGSTLFSGYTDGVIRVW 689 >6QX9-5O nrPDB Length = 357 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/155 (23%), Positives = 76/155 (49%), Gaps = 17/155 (10%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH+ V+ + G +A+ D+ I ++ + D N+ + + H +++ + + + Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA---TLKGHSGAVMELHYNT 119 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G ++ SAS DKTV +W+ + +G R +L S Y PA G +L Sbjct: 120 D--GSMLFSASTDKTVAVWDSE------TGERVKRLKGHTSFVNSCY-----PARRGPQL 166 Query: 126 ACLG-NDGILRLYDALEPSDLRSWTLTSEMKVLSI 159 C G +DG ++L+D + + ++++ T ++ ++ Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTF 201 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 34/145 (23%), Positives = 65/145 (44%), Gaps = 19/145 (13%) Query: 207 KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNM--- 263 +L GH S + S A R QL+ TG DG ++++ I +K A+ ++ N+ Sbjct: 146 RLKGHTSFVNSCYPAR---RGPQLVCTGSDDGTVKLWDIRKK----AAIQTFQNTYQVLA 198 Query: 264 --FDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSS 321 F++++D + N + +L+ N + H D V +S + G+ L S Sbjct: 199 VTFNDTSDQIISG---GIDNDIKVWDLRQNKLTYTMRGHAD---SVTGLSLSSEGSYLLS 252 Query: 322 AGDDGKVRLWKA-TYSNEFKCMSVI 345 D VR+W ++ + +C+ + Sbjct: 253 NAMDNTVRVWDVRPFAPKERCVKIF 277 Score = 28.1 bits (61), Expect = 5.6, Method: Compositional matrix adjust. Identities = 18/44 (40%), Positives = 27/44 (61%), Gaps = 5/44 (11%) Query: 290 SNLQ--VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 S+LQ + LLS H+ GEV+ ++ G+ L+SAG D + LW Sbjct: 53 SSLQAPIMLLSGHE---GEVYCCKFHPNGSTLASAGFDRLILLW 93 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 45/95 (47%), Gaps = 10/95 (10%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 +Q F + + L V ++ + + D IKV+ L ++ +L+ + R H S+ Sbjct: 187 IQTFQNTYQVLA--VTFNDTSDQIISGGIDNDIKVWDLRQN----KLTYTMRGHADSVTG 240 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDP--DQEEC 93 + +S G + S + D TV++W+ P +E C Sbjct: 241 LSLSSE--GSYLLSNAMDNTVRVWDVRPFAPKERC 273 >6HQA-B nrPDB Length = 722 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 6/81 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V+ V + R++ +CS D+ ++++ LD + S++ H SS+ + ++ Sbjct: 451 GHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLD----TYTCLVSYKGHSSSVWDVKFSP- 505 Query: 67 EYGRIIASASYDKTVKLWEED 87 G A+AS+D+T +LW D Sbjct: 506 -MGHYFATASHDQTARLWSCD 525 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 61/279 (21%), Positives = 104/279 (37%), Gaps = 80/279 (28%) Query: 53 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 112 H ++ +D+ SP+ R + S S DKTV+LW D + L + S++ Sbjct: 451 GHSGAVYGVDF-SPD-NRYLISCSEDKTVRLWSLD---------TYTCLVSYKGHSSSVW 499 Query: 113 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLS 172 VKF+P +G A +D RL+ LR + A HL C+ Sbjct: 500 DVKFSP--MGHYFATASHDQTARLWSCDHIYPLRIF-------------AGHLNDVDCVE 544 Query: 173 WCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIA 232 + P+ S S+ + A ++ + + V GH I ++ +P GRW +A Sbjct: 545 FHPN--STYLFTGSSDKTARMWDIARGECVRV---FMGHSGAINCLAVSPD-GRW---LA 595 Query: 233 TGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL 292 + +D + ++ I+ A M GRS Sbjct: 596 SAGEDSVVCLWDISTGRRIKA------------------MRGHGRS-------------- 623 Query: 293 QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++S++++ GT+L S G D VR+W Sbjct: 624 -------------SIYSLAFSREGTVLVSTGADNSVRVW 649 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 61/134 (45%), Gaps = 16/134 (11%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH + V V + ++ T SSD+ +++ D + E + H +I + S Sbjct: 534 AGHLNDVDCVEFHPNSTYLFTGSSDKTARMW----DIARGECVRVFMGHSGAINCL-AVS 588 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 P+ GR +ASA D V LW + +GRR + + S+YS+ F + G L Sbjct: 589 PD-GRWLASAGEDSVVCLW------DISTGRRIKAM--RGHGRSSIYSLAF--SREGTVL 637 Query: 126 ACLGNDGILRLYDA 139 G D +R++D Sbjct: 638 VSTGADNSVRVWDV 651 >5OQL-J nrPDB Length = 912 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/75 (41%), Positives = 43/75 (57%), Gaps = 13/75 (17%) Query: 46 ELSDSWR--AHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCT 103 +L+ S R AHD I A+D SP G++ ASAS DKTVK+W D ++ E G Sbjct: 533 KLTSSLRRLAHDKDINALD-ISPN-GKLFASASQDKTVKIW--DVEKLEVQG-------I 581 Query: 104 LNDSKGSLYSVKFAP 118 L K +++V+FAP Sbjct: 582 LRGHKRGVWTVRFAP 596 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 8/88 (9%) Query: 266 NSADVDM----DAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSS 321 NS D+ + DAQ S+ N E ++ V LL H+D V S+ + +G ++S Sbjct: 394 NSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHED---IVMSLDVDWSGHWIAS 450 Query: 322 AGDDGKVRLWKA-TYSNEFKCMSVITAQ 348 D RLW+ +N + C +V T Sbjct: 451 GSKDNTARLWRVDPANNSYTCYAVFTGH 478 Score = 31.6 bits (70), Expect = 0.47, Method: Compositional matrix adjust. Identities = 94/385 (24%), Positives = 145/385 (37%), Gaps = 79/385 (20%) Query: 1 MQPFD--SGHDDLVHDVVY---DFYGRHVATCSSDQHIKVFKLDKDTS--NWEL-SDSWR 52 ++PF SG D + D+ Y D +AT S D I K + S N E S S+ Sbjct: 363 LEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYF 422 Query: 53 AHDSSIVA----------IDWASPEYGRIIASASYDKTVKLWEEDP--DQEECSGRRWNK 100 HD +++ +DW+ G IAS S D T +LW DP + C Sbjct: 423 GHDVALLKGHEDIVMSLDVDWS----GHWIASGSKDNTARLWRVDPANNSYTCYAVFTGH 478 Query: 101 LCTLNDSKGSLYSVKFAPA-----------HLGLKLACLGNDGILRLYDALEPSDL-RSW 148 L +S G++ K P H L D ++ D P L + Sbjct: 479 L----ESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDI--PRQLQKGG 532 Query: 149 TLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKL 208 LTS ++ L+ H + L P+ KL SA + + + KL V L Sbjct: 533 KLTSSLRRLA-----HDKDINALDISPN----GKLFASASQDKTVKIWDVE-KLEVQGIL 582 Query: 209 PGHKSLIRSISWAPSIGRWYQ----------LIATGCKDGRIRIFKITEKLSPLASEESL 258 GHK + ++ +AP Q ++ TG D I+++ +++ E Sbjct: 583 RGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFE--- 639 Query: 259 TNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE-----------V 307 N V R DS T+ K + S L+ D + GE + Sbjct: 640 ---GHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRL 696 Query: 308 WSVSWNLTGTILSSAGDDGKVRLWK 332 W+++ + IL+SAG D KV W+ Sbjct: 697 WTLAVHSKTNILASAGSDSKVTFWR 721 Score = 30.8 bits (68), Expect = 0.89, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 8/81 (9%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWR---AHDSSIVAIDW 63 G +D ++ F +A + D I++F L K T+ +D R AH+S++ I + Sbjct: 184 GQNDDADEIASRF---RLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAY 240 Query: 64 ASPEYGRIIASASYDKTVKLW 84 SPE ++ S S DKT+ LW Sbjct: 241 -SPEQHALL-SGSRDKTMTLW 259 >5MZH-A nrPDB Length = 452 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 7/89 (7%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 GH ++V+ + ++ YG + T S D+ K++ D +L + + H + IV + + + Sbjct: 134 GHKNVVYAIAFNNPYGDKIVTGSFDKTCKLW----DAYTGQLYYTLKGHQTEIVCLSF-N 188 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECS 94 P+ IIA+ S D T KLW+ + QE + Sbjct: 189 PQ-STIIATGSMDNTAKLWDVETGQERAT 216 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 63/139 (45%), Gaps = 15/139 (10%) Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT--EKLSPLASEESLTNSNMFD 265 L GH++ I +S+ P +IATG D +++ + ++ + LA + S F+ Sbjct: 175 LKGHQTEIVCLSFNPQ----STIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFN 230 Query: 266 NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDD 325 D+ + DS ++++ V +LS H GEV S +N GT++ S D Sbjct: 231 TGGDLIVTGSFDHDSRL---WDVRTGQCVHVLS---GHRGEVSSTQFNYAGTLVVSGSID 284 Query: 326 GKVRLWKATYSNEFKCMSV 344 RLW +C+SV Sbjct: 285 CTSRLWDV---RSGRCLSV 300 Score = 36.2 bits (82), Expect = 0.020, Method: Compositional matrix adjust. Identities = 65/296 (21%), Positives = 113/296 (38%), Gaps = 42/296 (14%) Query: 38 LDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRR 97 L++ ++ L RAH + + A + G + SYD+T K+W +E Sbjct: 77 LEQQHHSFTLFKVLRAHILPLT--NCAFNKSGDRFITGSYDRTCKVWNTFTGEE------ 128 Query: 98 WNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVL 157 + TL K +Y++ F + G K+ D +L+DA L Sbjct: 129 ---VFTLEGHKNVVYAIAFNNPY-GDKIVTGSFDKTCKLWDAYTGQ-------------L 171 Query: 158 SIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRS 217 H CLS+ P +A +++ + G+ A L GH++ I S Sbjct: 172 YYTLKGHQTEIVCLSFNPQ---STIIATGSMDNTAKLWDVETGQER--ATLAGHRAEIVS 226 Query: 218 ISWAPSIGRWYQLIATGCKDGRIRI--FKITEKLSPLASEESLTNSNMFDNSADVDMDAQ 275 + + LI TG D R+ + + + L+ +S F+ + + + Sbjct: 227 LGFNTG----GDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSG- 281 Query: 276 GRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 S T +++S LS H EV V+++ GT + SA DG RL+ Sbjct: 282 --SIDCTSRLWDVRSG---RCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLY 332 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 43/87 (49%), Gaps = 8/87 (9%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D V DV +D G + + S+D +++ T + H+ I + + +P Sbjct: 303 GHTDEVLDVAFDAAGTKMVSASADGSARLYH----TLTGVCQHTLVGHEGEISKVAF-NP 357 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEEC 93 + R+I +AS DKT +LW D D EC Sbjct: 358 QGTRLI-TASSDKTCRLW--DCDTGEC 381 >5GAN-H nrPDB Length = 465 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 59/149 (39%), Gaps = 37/149 (24%) Query: 23 HVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVK 82 + +C+ D IK F+ + L H+ I + + G+ I SAS+D T + Sbjct: 233 QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPS--GKFIGSASHDMTWR 290 Query: 83 LWEEDPDQE----------------------ECSG-----------RRWNKLCTLNDSKG 109 LW+ QE CSG R +K+ TL Sbjct: 291 LWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSK 350 Query: 110 SLYSVKFAPAHLGLKLACLGNDGILRLYD 138 +Y+V ++P G ++A G DGI+ ++D Sbjct: 351 PIYTVAWSPN--GYQVATGGGDGIINVWD 377 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 8/85 (9%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVF---KLDKDTSNWELSDSWRAHDSSIVAID 62 +GH ++ V + G VAT D I V+ K D+ N L AH + + + Sbjct: 346 AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQIL-----AHRNIVTQVR 400 Query: 63 WASPEYGRIIASASYDKTVKLWEED 87 ++ + G+ + S YD + ++ D Sbjct: 401 FSKEDGGKKLVSCGYDNLINVYSSD 425 >5WLC-LO nrPDB Length = 923 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/79 (34%), Positives = 45/79 (56%), Gaps = 6/79 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + + Y G V T S D IKV+ + TS + L+ ++ H SS+ A+ +A Sbjct: 343 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDI---TSGFCLA-TFEEHTSSVTAVQFA-- 396 Query: 67 EYGRIIASASYDKTVKLWE 85 + G+++ S+S D TV+ W+ Sbjct: 397 KRGQVMFSSSLDGTVRAWD 415 >5I2T-A nrPDB Length = 742 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/79 (34%), Positives = 45/79 (56%), Gaps = 6/79 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + + Y G V T S D IKV+ + TS + L+ ++ H SS+ A+ +A Sbjct: 368 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDI---TSGFCLA-TFEEHTSSVTAVQFA-- 421 Query: 67 EYGRIIASASYDKTVKLWE 85 + G+++ S+S D TV+ W+ Sbjct: 422 KRGQVMFSSSLDGTVRAWD 440 >5NNZ-B nrPDB Length = 415 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 6/85 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GHDD + D +D+ G+ +AT S+D ++F +L H+ I I + + Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL----EGHEGEISKISF-N 354 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQ 90 P+ G + + S DKT ++W+ Q Sbjct: 355 PQ-GNHLLTGSSDKTARIWDAQTGQ 378 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 67/309 (21%), Positives = 128/309 (41%), Gaps = 49/309 (15%) Query: 41 DTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNK 100 DT++ E ++ H + + AI + +P YG IA+ S+DKT KLW + +G+ ++ Sbjct: 120 DTASGEELNTLEGHRNVVYAIAFNNP-YGDKIATGSFDKTCKLWSVE------TGKCYH- 171 Query: 101 LCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP 160 T + + F P + + D +L+D ++ +TL Sbjct: 172 --TFRGHTAEIVCLSFNPQSTLVATGSM--DTTAKLWDIQNGEEV--YTL---------- 215 Query: 161 PANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDG-KLHVAAKLPGHKSLIRSIS 219 H LS+ S +++ + + ++ G K+++ L GH + I S S Sbjct: 216 -RGHSAEIISLSF---NTSGDRIITGSFDHTVVVWDADTGRKVNI---LIGHCAEISSAS 268 Query: 220 WAPSIGRW-YQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGR- 277 + W LI TG D +++ T +LT + D D D G+ Sbjct: 269 F-----NWDCSLILTGSMDKTCKLWDATNG----KCVATLTGHD--DEILDSCFDYTGKL 317 Query: 278 -SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYS 336 + ++ + A + S + +++ + H GE+ +S+N G L + D R+W A Sbjct: 318 IATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG 377 Query: 337 NEFKCMSVI 345 +C+ V+ Sbjct: 378 ---QCLQVL 383 Score = 32.3 bits (72), Expect = 0.31, Method: Compositional matrix adjust. Identities = 59/267 (22%), Positives = 104/267 (38%), Gaps = 40/267 (14%) Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 G + SYD+T KLW+ +E L TL + +Y++ F + G K+A Sbjct: 104 GSCFITGSYDRTCKLWDTASGEE---------LNTLEGHRNVVYAIAFNNPY-GDKIATG 153 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSAL 188 D +L+ ++ H CLS+ P ++ Sbjct: 154 SFDKTCKLWSVETGKCYHTF-------------RGHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 189 EQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF--KIT 246 + Q G++ L GH + I S+S+ S R I TG D + ++ Sbjct: 201 AKLWDIQNGEE-----VYTLRGHSAEIISLSFNTSGDR----IITGSFDHTVVVWDADTG 251 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 K++ L + +S F+ D + G D T + + + V L+ HDD E Sbjct: 252 RKVNILIGHCAEISSASFN--WDCSLILTGSMD-KTCKLWDATNGKCVATLTGHDD---E 305 Query: 307 VWSVSWNLTGTILSSAGDDGKVRLWKA 333 + ++ TG ++++A DG R++ A Sbjct: 306 ILDSCFDYTGKLIATASADGTARIFSA 332 >5K1B-B nrPDB Length = 677 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 61/131 (46%), Gaps = 8/131 (6%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D V+D+V G+ + + SSD +KV+ K L R H + A+ +A + Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTL----RTHKDYVKALAYAKDK 129 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 ++ASA D+ + LW+ + + +L+ +K S+YS A LG + Sbjct: 130 --ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYS--LAMNQLGTIIVS 185 Query: 128 LGNDGILRLYD 138 + +LR++D Sbjct: 186 GSTEKVLRVWD 196 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 29/129 (22%), Positives = 56/129 (43%), Gaps = 9/129 (6%) Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS 267 L HK ++++++A +L+A+ D +I ++ + + AS ++T S++ N Sbjct: 113 LRTHKDYVKALAYAKD----KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNK 168 Query: 268 ADV---DMDAQGR--SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSA 322 + M+ G +TE+ + L + H V ++ N GT S Sbjct: 169 DSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSG 228 Query: 323 GDDGKVRLW 331 DG +RLW Sbjct: 229 SSDGTIRLW 237 >1NR0-A nrPDB Length = 611 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 5/81 (6%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFK-LDKDTSNWELSDSWR--AHDSSIVAIDWA 64 H VH V Y+ G A+ D I ++ +D + DS + AH S+ + W Sbjct: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTW- 247 Query: 65 SPEYGRIIASASYDKTVKLWE 85 SP+ G IASAS DKT+K+W Sbjct: 248 SPD-GTKIASASADKTIKIWN 267 Score = 31.2 bits (69), Expect = 0.79, Method: Compositional matrix adjust. Identities = 27/133 (20%), Positives = 56/133 (42%), Gaps = 14/133 (10%) Query: 206 AKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 265 L G + S+ + PS R +++I+ G D + IF+ P + + F Sbjct: 141 GNLTGQARAMNSVDFKPS--RPFRIIS-GSDDNTVAIFE----GPPFKFKSTFGEHTKFV 193 Query: 266 NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDD-------HNGEVWSVSWNLTGTI 318 +S + D + + + L + + +D H+G V+ ++W+ GT Sbjct: 194 HSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK 253 Query: 319 LSSAGDDGKVRLW 331 ++SA D +++W Sbjct: 254 IASASADKTIKIW 266 >6QX9-4B nrPDB Length = 522 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 48/111 (43%), Gaps = 14/111 (12%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 F GH ++ + + G H+AT S D KV+ L + + + AH + + + + Sbjct: 402 FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP----AHQNLVTGVKF 457 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV 114 P +G + + +YD T K+W W+ L TL +G + + Sbjct: 458 -EPIHGNFLLTGAYDNTAKIWTHPG---------WSPLKTLAGHEGKVMGL 498 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 7/78 (8%) Query: 8 HDDLVHDVVYD-FYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H +LV V ++ +G + T + D K++ W + H+ ++ +D +S Sbjct: 448 HQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT----HPGWSPLKTLAGHEGKVMGLDISSD 503 Query: 67 EYGRIIASASYDKTVKLW 84 G++IA+ SYD+T KLW Sbjct: 504 --GQLIATCSYDRTFKLW 519 Score = 32.3 bits (72), Expect = 0.27, Method: Compositional matrix adjust. Identities = 16/69 (23%), Positives = 36/69 (52%), Gaps = 6/69 (8%) Query: 23 HVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVK 82 ++A+C++D +K++ LD D ++ H + + W GR + + YD++ + Sbjct: 295 NLASCAADGSVKLWSLDSDEPVADIE----GHTVRVARVMWHPS--GRFLGTTCYDRSWR 348 Query: 83 LWEEDPDQE 91 LW+ + +E Sbjct: 349 LWDLEAQEE 357 >6MZM-G nrPDB Length = 800 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 42/80 (52%), Gaps = 6/80 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH +H + + GR +AT ++D + ++ + EL + H ++ ++ ++ Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL----KGHTDTVCSLRFSR 721 Query: 66 PEYGRIIASASYDKTVKLWE 85 G I+AS S D TV+LW+ Sbjct: 722 D--GEILASGSMDNTVRLWD 739 Score = 34.3 bits (77), Expect = 0.079, Method: Compositional matrix adjust. Identities = 61/272 (22%), Positives = 95/272 (34%), Gaps = 89/272 (32%) Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV---KFAPAHLGLKLACL 128 + S+S D TV+LW L KG Y V +F+P G Sbjct: 558 LLSSSEDGTVRLWS------------LQTFTCLVGYKGHNYPVWDTQFSP--YGYYFVSG 603 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK--LAVS 186 G+D + RL+ LR + A HL C +RF P +A Sbjct: 604 GHDRVARLWATDHYQPLRIF-------------AGHLADVNC-----TRFHPNSNYVATG 645 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + ++ + +G + GHK I S++++P+ GR+ +ATG DGR+ ++ I Sbjct: 646 SADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTFSPN-GRF---LATGATDGRVLLWDIG 699 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 L ++ E H Sbjct: 700 HGL----------------------------------------------MVGELKGHTDT 713 Query: 307 VWSVSWNLTGTILSSAGDDGKVRLWKATYSNE 338 V S+ ++ G IL+S D VRLW A + E Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 21/40 (52%), Gaps = 3/40 (7%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCM 342 H+G V+ S++ L S+ +DG VRLW F C+ Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSL---QTFTCL 578 >6GMH-W nrPDB Length = 305 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 69/314 (21%), Positives = 124/314 (39%), Gaps = 59/314 (18%) Query: 52 RAHDSSIVAIDWAS--PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKG 109 +AHD +I ++ W + E + + S D VK+W+ ++E +W +L + Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---RDERLDLQW----SLEGHQL 65 Query: 110 SLYSVKFAPAHLGLKLACLGNDGILRLYD--------ALEPSDLRSWTLTSEMKVLSIPP 161 + SV + H A D +RL+D +++ + +WTL + Sbjct: 66 GVVSVDIS--HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLAT 123 Query: 162 ANHL-------------------QSDFCLSWCPSRFSPEK--LAVSALEQAI-IYQRGKD 199 H+ + F LS +SP+ LA A++ I I+ Sbjct: 124 GTHVGKVNIFGVESGKKEYSLDTRGKFILSIA---YSPDGKYLASGAIDGIINIFDIATG 180 Query: 200 GKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEK--LSPLASEES 257 LH L GH IRS++++P QL+ T DG I+I+ + L+ S Sbjct: 181 KLLHT---LEGHAMPIRSLTFSPD----SQLLVTASDDGYIKIYDVQHANLAGTLSGHAS 233 Query: 258 LTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT 317 + F D S + + ++ + V +H D +VW V +N G+ Sbjct: 234 WVLNVAF---CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQD---QVWGVKYNGNGS 287 Query: 318 ILSSAGDDGKVRLW 331 + S GDD ++ ++ Sbjct: 288 KIVSVGDDQEIHIY 301 >6F3T-A nrPDB Length = 608 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 42/80 (52%), Gaps = 6/80 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH +H + + GR +AT ++D + ++ + EL + H ++ ++ ++ Sbjct: 474 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL----KGHTDTVCSLRFSR 529 Query: 66 PEYGRIIASASYDKTVKLWE 85 G I+AS S D TV+LW+ Sbjct: 530 D--GEILASGSMDNTVRLWD 547 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 64/287 (22%), Positives = 99/287 (34%), Gaps = 96/287 (33%) Query: 64 ASPEYG-------RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV-- 114 + P YG + S+S D TV+LW L KG Y V Sbjct: 351 SGPVYGASFSPDRNYLLSSSEDGTVRLWS------------LQTFTCLVGYKGHNYPVWD 398 Query: 115 -KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 173 +F+P G G+D + RL+ LR + A HL C Sbjct: 399 TQFSP--YGYYFVSGGHDRVARLWATDHYQPLRIF-------------AGHLADVNC--- 440 Query: 174 CPSRFSPEK--LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 +RF P +A + ++ + +G + GHK I S++++P+ GR+ + Sbjct: 441 --TRFHPNSNYVATGSADRTVRLWDVLNG--NCVRIFTGHKGPIHSLTFSPN-GRF---L 492 Query: 232 ATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSN 291 ATG DGR+ ++ I L Sbjct: 493 ATGATDGRVLLWDIGHGL------------------------------------------ 510 Query: 292 LQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNE 338 ++ E H V S+ ++ G IL+S D VRLW A + E Sbjct: 511 ----MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 553 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 18/113 (15%) Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 LIA G D +R++ +T K L S + ++ ++ D SD E + + Sbjct: 292 LIAGGFADSTVRVWSVTPK--KLRSVKQASDLSLIDK----------ESDDVLERIMDEK 339 Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCM 342 + ++++L H+G V+ S++ L S+ +DG VRLW F C+ Sbjct: 340 TASELKILY---GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL---QTFTCL 386 >4A11-B nrPDB Length = 408 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 66/318 (20%), Positives = 116/318 (36%), Gaps = 77/318 (24%) Query: 29 SDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDP 88 S + + +L+KD D R H I +D P GR + S D + L++ + Sbjct: 23 STRRVLGLELNKD------RDVERIHGGGINTLD-IEPVEGRYMLSGGSDGVIVLYDLE- 74 Query: 89 DQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALE-----PS 143 N S+ S Y+ K + +G D ++E P Sbjct: 75 ----------------NSSRQSYYTCK--------AVCSIGRDHPDVHRYSVETVQWYPH 110 Query: 144 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKL 202 D +T +S K L + N LQ+ ++ + +S VS + + RG +L Sbjct: 111 DTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQL 170 Query: 203 ------HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 256 + L GH+ I ++SW+P R+ ++AT D R++++ + L Sbjct: 171 CDLKSGSCSHILQGHRQEILAVSWSP---RYDYILATASADSRVKLWDVRRASGCL---- 223 Query: 257 SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTG 316 + +D S E A HNG+V + + G Sbjct: 224 -------------ITLDQHNGKKSQAVESANTA-------------HNGKVNGLCFTSDG 257 Query: 317 TILSSAGDDGKVRLWKAT 334 L + G D ++RLW ++ Sbjct: 258 LHLLTVGTDNRMRLWNSS 275 Score = 28.1 bits (61), Expect = 5.8, Method: Compositional matrix adjust. Identities = 33/164 (20%), Positives = 66/164 (40%), Gaps = 32/164 (19%) Query: 21 GRHVATCSSDQHIKVFKLDKDTSNWELS---------DSWRAHDSSIVAIDWASPEYGRI 71 GR++ + SD I ++ L+ + + D H S+ + W + G + Sbjct: 56 GRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTG-M 114 Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGND 131 S+S+DKT+K+W+ + Q + + + ++YS +P L +G Sbjct: 115 FTSSSFDKTLKVWDTNTLQTA----------DVFNFEETVYSHHMSPVSTKHCLVAVGTR 164 Query: 132 GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 175 G ++ DL+S + + ++ H Q +SW P Sbjct: 165 G-----PKVQLCDLKSGSCSHILQ-------GHRQEILAVSWSP 196 >6F1U-h nrPDB Length = 612 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 16/106 (15%) Query: 35 VFKLDKDTSNWELSDSWRAHDSSIVAID----WASPEYGRIIASASYDKTVKLWEEDPDQ 90 V+ + S +S+ + H I I + ++ + ++S+D TVKLW Sbjct: 430 VYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLW------ 483 Query: 91 EECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRL 136 S + L + D+ G +Y V ++P H L AC+ DG+ RL Sbjct: 484 ---STKNNKPLYSFEDNAGYVYDVMWSPTHPAL-FACV--DGMGRL 523 >5MC6-j nrPDB Length = 397 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 41/123 (33%), Positives = 57/123 (46%), Gaps = 24/123 (19%) Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS---ADVDMDAQGR-----SDSN 281 LIATG +G ++I +++ L PL + ES +M +NS V QG DSN Sbjct: 199 LIATGFNNGTVQISELS-TLRPLYNFES--QHSMINNSNSIRSVKFSPQGSLLAIAHDSN 255 Query: 282 T--------EEKAELQSNLQVELLSEHDD-----HNGEVWSVSWNLTGTILSSAGDDGKV 328 + E E +L V S H+ V S+S+N +G L SAG DGK+ Sbjct: 256 SFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKL 315 Query: 329 RLW 331 R W Sbjct: 316 RFW 318 >6HHQ-h nrPDB Length = 319 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 67/143 (46%), Gaps = 8/143 (5%) Query: 207 KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEK-LSPLASEESLTNSNMFD 265 + GHKS + S+ I + +I +G +D I+++ I + L+ L + Sbjct: 102 RFVGHKSDVMSVD----IDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVV 157 Query: 266 NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDD 325 + D D+ + ++ + + Q ++ ++ HN + +++ + GT+++SAG D Sbjct: 158 PNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKD 217 Query: 326 GKVRLWKATYSNEFKCMSVITAQ 348 G++ LW K M ++AQ Sbjct: 218 GEIMLWNLAAK---KAMYTLSAQ 237 Score = 30.8 bits (68), Expect = 0.90, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 38/78 (48%), Gaps = 6/78 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH +V D G + + S D+ ++++ D + E + H S ++++D Sbjct: 63 GHSHIVQDCTLTADGAYALSASWDKTLRLW----DVATGETYQRFVGHKSDVMSVD--ID 116 Query: 67 EYGRIIASASYDKTVKLW 84 + +I S S DKT+K+W Sbjct: 117 KKASMIISGSRDKTIKVW 134 >4V8M-A7 nrPDB Length = 318 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 113/295 (38%), Gaps = 59/295 (20%) Query: 52 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 111 R S D A G SAS+D +++LW Q C + L +K L Sbjct: 62 RLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQ--CQYK------FLGHTKDVL 113 Query: 112 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSE-MKVLSIPPANHLQSDFC 170 SV F+P + ++ G D LR+ W + E M LS H C Sbjct: 114 -SVAFSPDNR--QIVSGGRDNALRV-----------WNVKGECMHTLS--RGAHTDWVSC 157 Query: 171 LSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHV--------AAKLPGHKSLIRSISWAP 222 + RFSP +L+ +I G D + V L GH + + S++ +P Sbjct: 158 V-----RFSP------SLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSP 206 Query: 223 SIGRWYQLIATGCKDGRIRIFKIT--EKLSPLASEESLTNSNMFDNSA-DVDMDAQGRSD 279 L A+ KDG R++ +T E LS +A+ + N +G Sbjct: 207 D----GSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRI 262 Query: 280 SNTEEKAELQSNLQVELLSEHDDHNG---EVWSVSWNLTGTILSSAGDDGKVRLW 331 + E K ++ VEL EH E S++W+ G+ L S D +R+W Sbjct: 263 FDLENK-----DIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 61/140 (43%), Gaps = 11/140 (7%) Query: 207 KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN---SNM 263 K GH + S++++P + I +G +D +R++ + + S + T+ Sbjct: 104 KFLGHTKDVLSVAFSPD----NRQIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVR 159 Query: 264 FDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG 323 F S D + G D N + +L + L+++ H V SV+ + G++ +S+ Sbjct: 160 FSPSLDAPVIVSGGWD-NLVKVWDLATG---RLVTDLKGHTNYVTSVTVSPDGSLCASSD 215 Query: 324 DDGKVRLWKATYSNEFKCMS 343 DG RLW T M+ Sbjct: 216 KDGVARLWDLTKGEALSEMA 235 >5CXB-B nrPDB Length = 369 Score = 35.8 bits (81), Expect = 0.028, Method: Compositional matrix adjust. Identities = 15/30 (50%), Positives = 21/30 (70%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 H G V SV+ + TG L++ GDDG VR+W+ Sbjct: 20 HEGRVRSVAIDPTGVALATGGDDGTVRVWE 49 >5WYK-BB nrPDB Length = 943 Score = 35.8 bits (81), Expect = 0.032, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 41/84 (48%), Gaps = 6/84 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H D + +V + + +CS D +K + D +E AH S + A+ A+ Sbjct: 613 AHQDSIMNVKFLPQSHNFFSCSKDAVVKYW----DGEKFECIQKLYAHQSEVWALAVATD 668 Query: 67 EYGRIIASASYDKTVKLWEEDPDQ 90 G + S+S+D ++++WEE DQ Sbjct: 669 --GGFVVSSSHDHSIRIWEETEDQ 690 Score = 28.9 bits (63), Expect = 3.6, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 8/87 (9%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V + F + + T S+D++IK++ LD + S AH SI+ + + Sbjct: 571 GHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFG----DCHKSLFAHQDSIMNVKFLPQ 626 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEEC 93 + S S D VK W D ++ EC Sbjct: 627 SHN--FFSCSKDAVVKYW--DGEKFEC 649 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 22/33 (66%), Gaps = 2/33 (6%) Query: 53 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 85 AHD++I ++D S G+ + + S DKTVK W+ Sbjct: 471 AHDAAIWSLDLTSD--GKRLVTGSADKTVKFWD 501 >4XFV-A nrPDB Length = 792 Score = 35.0 bits (79), Expect = 0.042, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 1/65 (1%) Query: 21 GRHVATCSSDQHIKVFKLDKDTSNWELS-DSWRAHDSSIVAIDWASPEYGRIIASASYDK 79 G+ + + D+ +++ + + + +EL + + H I DWA E+G + +AS DK Sbjct: 622 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 681 Query: 80 TVKLW 84 TVK+W Sbjct: 682 TVKVW 686 >4V6W-Ag nrPDB Length = 318 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 20/135 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKL--DKDTSNWELSDSWRAHDSSIVAIDWA 64 GH + DVV G + + S DQ ++++ L K T +E H ++++ ++ Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFE------GHTKDVLSVAFS 115 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS-VKFAPAHLGL 123 + R I S S DKT+KLW EC K D S V+F+P H Sbjct: 116 ADN--RQIVSGSRDKTIKLWNT---LAEC------KFTIQEDGHTDWVSCVRFSPNHSNP 164 Query: 124 KLACLGNDGILRLYD 138 + G D +++++ Sbjct: 165 IIVSCGWDRTVKVWN 179 Score = 27.7 bits (60), Expect = 8.1, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 22/37 (59%) Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 +L + H HNG + +V+ + G++ +S G D K LW Sbjct: 184 KLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLW 220 >5WYJ-BC nrPDB Length = 817 Score = 34.7 bits (78), Expect = 0.058, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 43/81 (53%), Gaps = 3/81 (3%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI---DW 63 GH+DL++ + G +AT S D V++ ++++ +++ + H +++ A+ + Sbjct: 386 GHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNI 445 Query: 64 ASPEYGRIIASASYDKTVKLW 84 S Y + +AS D T+K W Sbjct: 446 VSKGYPEFLLTASNDLTIKKW 466 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 17/109 (15%) Query: 14 DVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWEL-----SDSWR-AHDSSIVAIDWASPE 67 ++V Y + T S+D IK + + K T++ ++ S+ R AH+ I A+ SP Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALS-VSPN 502 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKF 116 I A+ASYDKT K+W + + E TL + K L+ V F Sbjct: 503 -DSIFATASYDKTCKIWNLENGELE---------ATLANHKRGLWDVSF 541 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 33/136 (24%), Positives = 64/136 (47%), Gaps = 25/136 (18%) Query: 25 ATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLW 84 AT S D+ K++ L+ N EL + H + + + +Y +++A++S DKTVK+W Sbjct: 507 ATASYDKTCKIWNLE----NGELEATLANHKRGLWDVSFC--QYDKLLATSSGDKTVKIW 560 Query: 85 EEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYD------ 138 D ++ + TL ++ F L ++C G DG+++++D Sbjct: 561 SLD---------TFSVMKTLEGHTNAVQRCSFINKQKQL-ISC-GADGLIKIWDCSSGEC 609 Query: 139 --ALEPSDLRSWTLTS 152 L+ + R W L++ Sbjct: 610 LKTLDGHNNRLWALST 625 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 20/38 (52%) Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 E L D HN +W++S G ++ SA DG + WK Sbjct: 608 ECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWK 645 >5N4A-A nrPDB Length = 771 Score = 34.7 bits (78), Expect = 0.058, Method: Compositional matrix adjust. Identities = 13/31 (41%), Positives = 21/31 (67%) Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + H G S+ W+ GT L++AG+DG V++W Sbjct: 101 EGHKGACISLRWSYDGTALATAGEDGSVKIW 131 Score = 27.7 bits (60), Expect = 7.1, Method: Compositional matrix adjust. Identities = 35/130 (26%), Positives = 55/130 (42%), Gaps = 12/130 (9%) Query: 203 HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKL-SPLASEESLTNS 261 V + GHK S+ W+ +AT +DG ++I+ L S LA +S S Sbjct: 95 RVEKSIEGHKGACISLRWSYD----GTALATAGEDGSVKIWSRNGMLRSTLAQADSPVYS 150 Query: 262 NMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSS 321 ++ D G SN K+ L SN + HD G V V W+ ++ + Sbjct: 151 IVWAYDCDQLCYCTG---SNVVIKS-LSSNAKQNAWKAHD---GVVLKVDWSPINHLIIT 203 Query: 322 AGDDGKVRLW 331 G+D K ++W Sbjct: 204 GGEDCKYKVW 213 >5FA5-B nrPDB Length = 367 Score = 34.3 bits (77), Expect = 0.089, Method: Compositional matrix adjust. Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 5/78 (6%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 HDD+V V G + S D IKV+ L + + S+RAH + + + ASP Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVA-ASPH 203 Query: 68 YGRIIASASYDKTVKLWE 85 + S S D + LW+ Sbjct: 204 KDSVFLSCSEDNRILLWD 221 >3JAP-g nrPDB Length = 326 Score = 33.9 bits (76), Expect = 0.098, Method: Compositional matrix adjust. Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 6/83 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH +V DVV G + + S D+ ++++ L T N E D VAID S Sbjct: 64 GHSHIVQDVVVSADGNYAVSASWDKTLRLWNL--ATGNSEARFVGHTGDVLSVAIDANSS 121 Query: 67 EYGRIIASASYDKTVKLWEEDPD 89 + I SAS DKT+++W D Sbjct: 122 K----IISASRDKTIRVWNTVGD 140 >6G51-g nrPDB Length = 317 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V DVV G+ + S D ++++ L T+ + + H ++++ ++S Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT----TRRFVGHTKDVLSVAFSSD 116 Query: 67 EYGRIIASASYDKTVKLWE 85 R I S S DKT+KLW Sbjct: 117 N--RQIVSGSRDKTIKLWN 133 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 31/241 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V V + R + + S D+ IK++ + + D +H + + ++ Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQD--ESHSEWVSCVRFSPN 159 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN-DSKGSLYSVKFAPAHLGLKL 125 II S +DK VK+W + C KL T + G L +V +P G Sbjct: 160 SSNPIIVSCGWDKLVKVW----NLANC------KLKTNHIGHTGYLNTVTVSPD--GSLC 207 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 A G DG L+D E L + + L P + C + PS + + Sbjct: 208 ASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYW---LCAATGPS------IKI 258 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 LE II K + ++K S++W+ Q + G D +R++++ Sbjct: 259 WDLEGKIIVDELKQEVISTSSK--AEPPQCTSLAWSAD----GQTLFAGYTDNLVRVWQV 312 Query: 246 T 246 T Sbjct: 313 T 313 >3DWL-C nrPDB Length = 377 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 38/66 (57%), Gaps = 5/66 (7%) Query: 24 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 83 V T +++Q V ++D + W+ + ++ HD + +DWA P+ RI+ + S D+ + Sbjct: 27 VTTTATNQ---VELYEQDGNGWKHARTFSDHDKIVTCVDWA-PKSNRIV-TCSQDRNAYV 81 Query: 84 WEEDPD 89 +E+ PD Sbjct: 82 YEKRPD 87 >5OPT-p nrPDB Length = 318 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 70/297 (23%), Positives = 113/297 (38%), Gaps = 57/297 (19%) Query: 52 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 111 R S D A G SAS+D +++LW +G +K L +K L Sbjct: 62 RLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQ------TGVCQHKF--LGHTKDVL 113 Query: 112 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 171 SV F+P + ++ G D LR+ W + E + ++ H C+ Sbjct: 114 -SVTFSPDNR--QIVSGGRDNALRV-----------WNVKGEC-LHTLGRGAHTDWVSCV 158 Query: 172 SWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHV--------AAKLPGHKSLIRSISWAPS 223 RFSP +LE +I G D + V L GH + I S++ +P Sbjct: 159 -----RFSP------SLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPD 207 Query: 224 IGRWYQLIATGCKDGRIRIFKIT--EKLSPLASEESLT----NSNMFDNSADVDMDAQGR 277 L A+ KDG R++ +T E LS +A+ + + N + A + + Sbjct: 208 ----GSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIF 263 Query: 278 SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 N + EL Q + E S++W+ G L S D +R+W + Sbjct: 264 DLENKDVIVELAPEAQ-----QKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 61/140 (43%), Gaps = 11/140 (7%) Query: 207 KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT-EKLSPLA--SEESLTNSNM 263 K GH + S++++P + I +G +D +R++ + E L L + + Sbjct: 104 KFLGHTKDVLSVTFSPD----NRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVR 159 Query: 264 FDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG 323 F S + + G D N + ++ S LL++ H + SV+ + G++ +S+ Sbjct: 160 FSPSLETPLIVSGGWD-NLVKVWDIASG---RLLTDLKGHTNYITSVTVSPDGSLCASSD 215 Query: 324 DDGKVRLWKATYSNEFKCMS 343 DG RLW T M+ Sbjct: 216 KDGVARLWDLTKGEALSEMA 235 >5NZU-C nrPDB Length = 905 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 58/133 (43%), Gaps = 18/133 (13%) Query: 7 GHDDLVHDVVYDFY-GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 GH V +V + A+ S D+ IKV++L + N+ L H+ + ID+ S Sbjct: 140 GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL----EGHEKGVNCIDYYS 195 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + S + D+ VK+W+ NK C + +G +V A H L + Sbjct: 196 GGDKPYLISGADDRLVKIWDYQ-----------NKTC-VQTLEGHAQNVSCASFHPELPI 243 Query: 126 ACLGN-DGILRLY 137 G+ DG +R++ Sbjct: 244 IITGSEDGTVRIW 256 Score = 32.0 bits (71), Expect = 0.37, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 4/79 (5%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H D + + + T S D IK++ DK W S + H ++ I +P Sbjct: 97 AHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK---KWSCSQVFEGHTHYVMQI-VINP 152 Query: 67 EYGRIIASASYDKTVKLWE 85 + ASAS D+T+K+W+ Sbjct: 153 KDNNQFASASLDRTIKVWQ 171 >4UII-A nrPDB Length = 217 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 22/96 (22%), Positives = 41/96 (42%), Gaps = 19/96 (19%) Query: 190 QAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKL 249 QA+I Q+ + G++H K+P H L+ G + R R+F + + Sbjct: 135 QALIAQQKQIGEIHARIKIPIH------------------LVLRGARHLRERLFVLLRQ- 175 Query: 250 SPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 PL E L + + D+ M+ R+ S+ ++ Sbjct: 176 RPLDPEHKLFGQRLISETVDLAMEIMSRAFSDAYDR 211 >4V7E-Bg nrPDB Length = 380 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 41/176 (23%), Positives = 78/176 (44%), Gaps = 19/176 (10%) Query: 178 FSP--EKLAVSALEQA-----IIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQL 230 F+P + +A L+ A + Q +DG + V+ L GHK S + P + +L Sbjct: 116 FAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPD--QETRL 173 Query: 231 IATGCKDGRIRIFKIT--EKLSPLASEESLTNS----NMFDNSADVDMDAQGRSDSNTEE 284 I TG D ++ +T +++S SE ++ ++ NS + +M G D+ T Sbjct: 174 I-TGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDT-TVR 231 Query: 285 KAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 340 +L+ + + + H G++ SV + G + DDG RL+ ++ + Sbjct: 232 LWDLR--ITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQ 285 >4OWR-A nrPDB Length = 339 Score = 33.1 bits (74), Expect = 0.21, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 6/71 (8%) Query: 21 GRHVATCSSDQHIKVF--KLDKDTSNWELSDSWR----AHDSSIVAIDWASPEYGRIIAS 74 G + C SD KVF DK W+LS + HD+ + I W + + Sbjct: 58 GPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMT 117 Query: 75 ASYDKTVKLWE 85 S+DKT+K W+ Sbjct: 118 GSWDKTLKFWD 128 >5WJC-A nrPDB Length = 430 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 58/115 (50%), Gaps = 17/115 (14%) Query: 8 HDDLVHDVVYDFYGRH---VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 H D+V+DV F+ +H +A+ S D +++ + E +AH +I A+ Sbjct: 234 HTDIVNDV--QFHPQHEALLASVSDDCTLQIHDTRLNPEE-EAPKVIQAHSKAINAVA-I 289 Query: 65 SPEYGRIIASASYDKTVKLWE-EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 +P ++A+AS DKTV LW+ +P + +L TL + +Y ++++P Sbjct: 290 NPFNDYLLATASADKTVALWDLRNP---------YQRLHTLEGHEDEVYGLEWSP 335 Score = 27.7 bits (60), Expect = 8.0, Method: Compositional matrix adjust. Identities = 15/53 (28%), Positives = 29/53 (54%), Gaps = 7/53 (13%) Query: 39 DKDTSNWELSDSWR------AHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 85 DK + W+L + ++ H+ + ++W SP I+AS+S D+ V +W+ Sbjct: 303 DKTVALWDLRNPYQRLHTLEGHEDEVYGLEW-SPHDEPILASSSTDRRVCIWD 354 >3ACP-A nrPDB Length = 417 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 33/65 (50%), Gaps = 6/65 (9%) Query: 21 GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKT 80 G + + S D +K++ + KD SN RA + I ID GR + SAS D T Sbjct: 148 GEALISSSQDMQLKIWSV-KDGSNPRTLIGHRATVTDIAIIDR-----GRNVLSASLDGT 201 Query: 81 VKLWE 85 ++LWE Sbjct: 202 IRLWE 206 >5Z56-q nrPDB Length = 504 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 24/42 (57%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSV 344 H+G + S++++ G L++A DD V+LW FK + + Sbjct: 391 HSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL 432 >3W15-A nrPDB Length = 368 Score = 32.7 bits (73), Expect = 0.26, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 4/62 (6%) Query: 53 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 112 AH +I + W SP + I+ SASYD T ++W D + K + + +KGS++ Sbjct: 274 AHGLAIRKVTW-SPHHSNILMSASYDMTCRIWR---DLSNDGAKETYKTNSTDATKGSIF 329 Query: 113 SV 114 + Sbjct: 330 NF 331 Score = 30.8 bits (68), Expect = 0.82, Method: Compositional matrix adjust. Identities = 49/247 (19%), Positives = 97/247 (39%), Gaps = 55/247 (22%) Query: 11 LVHDVVYDF-----YGRHVATCSSDQHIKVFKLDKDTSNWELSDS-WRAHDSSIVAIDWA 64 L D ++D + V D +++F DT+ E + ++ H+ + + +W Sbjct: 60 LTQDCLFDLAWNESHENQVLVAQGDGTLRLF----DTTFKEFPIAIFKEHEREVFSCNWN 115 Query: 65 SPEYGRIIASASYDKTVKLWEE--------------------DPDQEECSGRRWNKLCTL 104 ++S S+D ++K+W DP ++ + Sbjct: 116 LVNRQNFLSS-SWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKK--SFTGI 172 Query: 105 NDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANH 164 + ++ +Y +F+P L L+C GN L+D PS ++ L Sbjct: 173 SKNRNCVYQAQFSPHDQNLVLSCSGNS-YASLFDIRLPSG------KNQNNFLVHSGLEA 225 Query: 165 LQSDFCLSWCPSRFSPEKLAVSALEQAI----IYQRGKD-GKLHVAA---KLP-GHKSLI 215 L DF +++ P +A ++ AI I K+ G+LH ++ ++P H I Sbjct: 226 LTCDF------NKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAI 279 Query: 216 RSISWAP 222 R ++W+P Sbjct: 280 RKVTWSP 286 >5OQL-d nrPDB Length = 446 Score = 32.3 bits (72), Expect = 0.32, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 39/66 (59%), Gaps = 7/66 (10%) Query: 23 HVATCSSDQHIKVFKLDKDTSNWELS-DSWRAHDSSIVAIDWASPEYGRIIASASYDKTV 81 ++A S D +I +F D N++ + + + H ++++ +++ SP G + S SYD+T+ Sbjct: 254 NLAVASEDHNIYIF----DARNFDKALNIQKGHVAAVMDVEF-SPT-GEELVSGSYDRTI 307 Query: 82 KLWEED 87 +LW D Sbjct: 308 RLWRRD 313 Score = 29.6 bits (65), Expect = 2.3, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 17/37 (45%) Query: 300 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYS 336 H V+ W + + + DDG VRLW+A S Sbjct: 322 HTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANAS 358 >5LE5-B nrPDB Length = 261 Score = 32.0 bits (71), Expect = 0.43, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 3/42 (7%) Query: 96 RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG---NDGIL 134 RR++ T+ +G LY V++A +G CLG NDG+L Sbjct: 3 RRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVL 44 >4LG8-A nrPDB Length = 354 Score = 32.0 bits (71), Expect = 0.46, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 24/42 (57%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSV 344 H+G + S++++ G L++A DD V+LW FK + + Sbjct: 241 HSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL 282 >5WLC-LS nrPDB Length = 594 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 13/31 (41%), Positives = 22/31 (70%) Query: 305 GEVWSVSWNLTGTILSSAGDDGKVRLWKATY 335 G+V SV+++ +G +L+ + GKVRLWK + Sbjct: 563 GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 >6EM1-m nrPDB Length = 807 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 24/36 (66%), Gaps = 4/36 (11%) Query: 210 GHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 GHK +R++S PS G W +ATG DG +R+++I Sbjct: 435 GHKGKVRTLSIDPS-GLW---LATGSDDGTVRVWEI 466 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 14/47 (29%), Positives = 27/47 (57%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 H G+V ++S + +G L++ DDG VR+W+ E ++I ++ Sbjct: 436 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEE 482 >5G04-R nrPDB Length = 499 Score = 31.6 bits (70), Expect = 0.56, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 3/81 (3%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC- 364 Query: 66 PEYGRIIAS--ASYDKTVKLW 84 P ++A+ + D+ +++W Sbjct: 365 PWQSNVLATGGGTSDRHIRIW 385 >3OC5-A nrPDB Length = 318 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 4/48 (8%) Query: 297 LSEHDDHNGEVWSVSW----NLTGTILSSAGDDGKVRLWKATYSNEFK 340 +S +D HNG WS + N IL + GD V+L+ YS FK Sbjct: 271 VSTNDMHNGYKWSNTMFSNSNYKTQILLTKGDGSGVKLYSKAYSENFK 318 >6C0F-s nrPDB Length = 807 Score = 31.6 bits (70), Expect = 0.60, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 24/36 (66%), Gaps = 4/36 (11%) Query: 210 GHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 GHK +R++S PS G W +ATG DG +R+++I Sbjct: 435 GHKGKVRTLSIDPS-GLW---LATGSDDGTVRVWEI 466 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 14/47 (29%), Positives = 27/47 (57%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 H G+V ++S + +G L++ DDG VR+W+ E ++I ++ Sbjct: 436 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEE 482 >3JB9-g nrPDB Length = 558 Score = 31.2 bits (69), Expect = 0.65, Method: Compositional matrix adjust. Identities = 20/67 (29%), Positives = 37/67 (55%), Gaps = 5/67 (7%) Query: 21 GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKT 80 G + + S D IK++++ D S L +++ H I + ++ + GR S S+DKT Sbjct: 279 GHLLLSGSMDNQIKIWEVYHDRS---LLRTFQGHARPIRDLSFS--QDGRSFLSTSFDKT 333 Query: 81 VKLWEED 87 +KLW+ + Sbjct: 334 IKLWDTE 340 Score = 28.1 bits (61), Expect = 5.3, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 37/78 (47%), Gaps = 5/78 (6%) Query: 256 ESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ-VELLSEHDDHNGEVWSVSWNL 314 + LTN F VD D + T +K LQ +++ +++ +D H G + S+++ Sbjct: 351 DRLTNCVKFQ----VDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLE 406 Query: 315 TGTILSSAGDDGKVRLWK 332 G + DD +R W+ Sbjct: 407 NGKRFVTTSDDSSMRFWE 424 >2P9P-C nrPDB Length = 372 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 19/96 (19%), Positives = 40/96 (41%), Gaps = 11/96 (11%) Query: 23 HVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVK 82 +A C ++ + ++ +K + W + H+ + +DWA P+ RI+ + D+ Sbjct: 22 QIAICPNNHEVHIY--EKSGNKWVQVHELKEHNGQVTGVDWA-PDSNRIVTCGT-DRNAY 77 Query: 83 LWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 +W GR W + + V++AP Sbjct: 78 VW-------TLKGRTWKPTLVILRINRAARCVRWAP 106 >3CFV-B nrPDB Length = 414 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 14/135 (10%) Query: 6 SGHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 +GH +V DV + + + + DQ + ++ +T++ + S AH + + + + Sbjct: 226 TGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTS-KPSHLVDAHTAEVNCLSF- 283 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWN-KLCTLNDSKGSLYSVKFAPAHLGL 123 +P I+A+ S DKTV LW+ R KL T K ++ V ++P H Sbjct: 284 NPYSEFILATGSADKTVALWDL---------RNLKLKLHTFESHKDEIFQVHWSP-HNET 333 Query: 124 KLACLGNDGILRLYD 138 LA G D L ++D Sbjct: 334 ILASSGTDRRLNVWD 348 >5M25-A nrPDB Length = 434 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V V + G +A+ S+D+ IK++ + + + H I + W+S Sbjct: 142 AGHTKAVSSVKFSPNGEWLASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSS 197 Query: 66 PEYGRIIASASYDKTVKLWE 85 ++ SAS DKT+K+W+ Sbjct: 198 DS--NLLVSASDDKTLKIWD 215 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 50/252 (19%), Positives = 99/252 (39%), Gaps = 57/252 (22%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH + DV + + + S D+ +K++ D S+ + + + H + + ++ + Sbjct: 184 SGHKLGISDVAWSSDSNLLVSASDDKTLKIW----DVSSGKCLKTLKGHSNYVFCCNF-N 238 Query: 66 PEYGRIIASASYDKTVKLWE-------------EDP--------DQEECSGRRWNKLC-- 102 P+ +I S S+D++V++W+ DP D ++ LC Sbjct: 239 PQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 297 Query: 103 -----------TLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLT 151 ++D + VKF+P + A L D L+L+D + L+++T Sbjct: 298 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL--DNTLKLWDYSKGKCLKTYT-- 353 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 H +C+ + + K VS E ++Y K + KL GH Sbjct: 354 -----------GHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQGH 400 Query: 212 KSLIRSISWAPS 223 ++ S + P+ Sbjct: 401 TDVVISTACHPT 412 >4GGA-A nrPDB Length = 420 Score = 31.2 bits (69), Expect = 0.72, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 3/81 (3%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 227 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC- 285 Query: 66 PEYGRIIAS--ASYDKTVKLW 84 P ++A+ + D+ +++W Sbjct: 286 PWQSNVLATGGGTSDRHIRIW 306 >6CB1-s nrPDB Length = 569 Score = 31.2 bits (69), Expect = 0.77, Method: Compositional matrix adjust. Identities = 14/43 (32%), Positives = 25/43 (58%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 H G+V ++S + +G L++ DDG VR+W+ E ++I Sbjct: 198 HKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLI 240 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 24/36 (66%), Gaps = 4/36 (11%) Query: 210 GHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 GHK +R++S PS G W +ATG DG +R+++I Sbjct: 197 GHKGKVRTLSIDPS-GLW---LATGSDDGTVRVWEI 228 >5LCW-Q nrPDB Length = 374 Score = 30.8 bits (68), Expect = 0.86, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 3/81 (3%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 181 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC- 239 Query: 66 PEYGRIIAS--ASYDKTVKLW 84 P ++A+ + D+ +++W Sbjct: 240 PWQSNVLATGGGTSDRHIRIW 260 >2H9P-A nrPDB Length = 329 Score = 30.8 bits (68), Expect = 0.87, Method: Compositional matrix adjust. Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V V + G +A+ S+D+ IK++ + + + H I + W+S Sbjct: 37 AGHTKAVSSVKFSPNGEWLASSSADKLIKIW----GAYDGKFEKTISGHKLGISDVAWSS 92 Query: 66 PEYGRIIASASYDKTVKLWE 85 ++ SAS DKT+K+W+ Sbjct: 93 DS--NLLVSASDDKTLKIWD 110 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 50/252 (19%), Positives = 99/252 (39%), Gaps = 57/252 (22%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH + DV + + + S D+ +K++ D S+ + + + H + + ++ + Sbjct: 79 SGHKLGISDVAWSSDSNLLVSASDDKTLKIW----DVSSGKCLKTLKGHSNYVFCCNF-N 133 Query: 66 PEYGRIIASASYDKTVKLWE-------------EDP--------DQEECSGRRWNKLC-- 102 P+ +I S S+D++V++W+ DP D ++ LC Sbjct: 134 PQ-SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 192 Query: 103 -----------TLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLT 151 ++D + VKF+P + A L D L+L+D + L+++T Sbjct: 193 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL--DNTLKLWDYSKGKCLKTYT-- 248 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 H +C+ + + K VS E ++Y K + KL GH Sbjct: 249 -----------GHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQTK-EIVQKLQGH 295 Query: 212 KSLIRSISWAPS 223 ++ S + P+ Sbjct: 296 TDVVISTACHPT 307 >5OQL-L nrPDB Length = 557 Score = 30.8 bits (68), Expect = 0.98, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 39/100 (39%), Gaps = 14/100 (14%) Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADV-DMDAQGRSDSNTEEKAELQ-----SNL 292 R+ IF I ++ E L FD+ A ++ GR E+ +Q Sbjct: 80 RVEIFSIRKR-------EPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGT 132 Query: 293 QVELLSEHDDHNGEVWSVSWNLTG-TILSSAGDDGKVRLW 331 + +L H VW W+ T T L S DD VRLW Sbjct: 133 RAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLW 172 Score = 28.1 bits (61), Expect = 6.3, Method: Compositional matrix adjust. Identities = 53/234 (22%), Positives = 89/234 (38%), Gaps = 49/234 (20%) Query: 21 GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKT 80 GR + ++VF + + T L +W H + W SP + S S DKT Sbjct: 111 GRVLVAGEDTGRMQVFDVGQGTRAVIL-KTWHIHKQPVWVTKW-SPTELTTLMSCSDDKT 168 Query: 81 VKLWE---EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGN-DGILRL 136 V+LW+ DP + + + C F P L G+ D +R+ Sbjct: 169 VRLWDLPSNDPTRLFTGHTDYVR-CG-----------AFMPGSANSNLLVSGSYDETVRV 216 Query: 137 YDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQR 196 +DA P V++ A+ ++ L + + A+S L+ Sbjct: 217 WDARAPGG----------AVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDL------ 260 Query: 197 GKDGKLHVAAK----LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 VAAK + H+ + S+S A S GR + +G DG +++F+ T Sbjct: 261 -------VAAKPLRLITNHQKTVTSLSLA-SQGRR---VVSGSLDGHVKVFETT 303 >3C9C-A nrPDB Length = 432 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 63/135 (46%), Gaps = 14/135 (10%) Query: 6 SGHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 +GH +V DV + + + + DQ + ++ + ++ + S + AH + + + + Sbjct: 230 TGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSF- 287 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWN-KLCTLNDSKGSLYSVKFAPAHLGL 123 +P I+A+ S DKTV LW+ R KL + K ++ V+++P H Sbjct: 288 NPYSEFILATGSADKTVALWD---------LRNLKLKLHSFESHKDEIFQVQWSP-HNET 337 Query: 124 KLACLGNDGILRLYD 138 LA G D L ++D Sbjct: 338 ILASSGTDRRLHVWD 352 >5Y1U-A nrPDB Length = 456 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 14/135 (10%) Query: 6 SGHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 +GH +V DV + + + + DQ + ++ + ++ + S S AH + + + + Sbjct: 255 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTS-KPSHSVDAHTAEVNCLSF- 312 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWN-KLCTLNDSKGSLYSVKFAPAHLGL 123 +P I+A+ S DKTV LW+ R KL + K ++ V+++P H Sbjct: 313 NPYSEFILATGSADKTVALWDL---------RNLKLKLHSFESHKDEIFQVQWSP-HNET 362 Query: 124 KLACLGNDGILRLYD 138 LA G D L ++D Sbjct: 363 ILASSGTDRRLNVWD 377 >4N14-A nrPDB Length = 314 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 38/81 (46%), Gaps = 3/81 (3%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 143 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC- 201 Query: 66 PEYGRIIAS--ASYDKTVKLW 84 P ++A+ + D+ +++W Sbjct: 202 PWQSNVLATGGGTSDRHIRIW 222 >3MKQ-A nrPDB Length = 814 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 18/77 (23%), Positives = 38/77 (49%), Gaps = 4/77 (5%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D + + +V + S D +K++ + +NW L ++ H+ ++ + + +P+ Sbjct: 96 HPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWE---NNWALEQTFEGHEHFVMCVAF-NPK 151 Query: 68 YGRIIASASYDKTVKLW 84 AS D+TVK+W Sbjct: 152 DPSTFASGCLDRTVKVW 168 >1PIE-A nrPDB Length = 419 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 5/67 (7%) Query: 280 SNTEEKAELQSNLQVELLSEHDDHNGE-VWSVSWNLTGTILSSAGDDGKVRLWKATYSNE 338 +T+E S ++ L+ EH D+NG V+ S + T L+ +D KV+L YS Sbjct: 43 GDTKEVEYFFSPGRINLIGEHTDYNGGYVFPASITIGTTGLARLREDKKVKL----YSEN 98 Query: 339 FKCMSVI 345 F + VI Sbjct: 99 FPKLGVI 105 >3T8I-A nrPDB Length = 306 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/50 (26%), Positives = 21/50 (42%) Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 112 W PE +I+ A +D T+ WE + R W + LN + + Sbjct: 165 WVDPEAAKIVLDAGFDITIVPWEVAEISGSLNERDWEYISKLNTKLSNFF 214 >6ELZ-p nrPDB Length = 460 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 34/57 (59%), Gaps = 6/57 (10%) Query: 287 ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMS 343 +L N+Q ++ H+G + +V + ++ T L SAG+D +RLWK T +++ K S Sbjct: 131 DLSGNVQ----KQYSGHSGPIRAVKY-ISNTRLVSAGNDRTLRLWK-TKNDDLKLTS 181 >6Q8F-A nrPDB Length = 514 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 31/131 (23%), Positives = 52/131 (39%), Gaps = 28/131 (21%) Query: 226 RWYQLIATGCKDGRIRIFKITE----KLSPLASEESLT-------NSNMFDNSADVDMDA 274 R +++ATG +DG+I+++KI + A + +T +S + S D + Sbjct: 275 RDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRI 334 Query: 275 QGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 G T L E H+ V ++ G + SA DG V++W Sbjct: 335 HGLKSGKT--------------LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 380 Query: 335 Y---SNEFKCM 342 SN FK + Sbjct: 381 TTECSNTFKSL 391 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 29/114 (25%), Positives = 49/114 (42%), Gaps = 12/114 (10%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 ++ F+ H V + + + + S DQ I++ L + E +R H S + Sbjct: 300 LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE----FRGHSSFVNE 355 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV 114 + + G I SAS D TVK+W + ECS N +L + G+ +V Sbjct: 356 ATFT--QDGHYIISASSDGTVKIW--NMKTTECS----NTFKSLGSTAGTDITV 401 >2YNP-A nrPDB Length = 604 Score = 30.0 bits (66), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/77 (23%), Positives = 38/77 (49%), Gaps = 4/77 (5%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D + + +V + S D +K++ + +NW L ++ H+ ++ + + +P+ Sbjct: 96 HPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWE---NNWALEQTFEGHEHFVMCVAF-NPK 151 Query: 68 YGRIIASASYDKTVKLW 84 AS D+TVK+W Sbjct: 152 DPSTFASGCLDRTVKVW 168 >5OV3-A nrPDB Length = 381 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 12/26 (46%), Positives = 16/26 (61%) Query: 217 SISWAPSIGRWYQLIATGCKDGRIRI 242 S++ + RW L+A GC DGRI I Sbjct: 26 SMALTCTFNRWGTLLAVGCNDGRIVI 51 >5OQL-X nrPDB Length = 630 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 36/78 (46%), Gaps = 6/78 (7%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D V + + + +CS D+ +KV+ LD+ ++ H I+ ID E Sbjct: 287 HRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDE----LAYVETLFGHQDEILDIDALGQE 342 Query: 68 YGRIIASASYDKTVKLWE 85 R ++ + D+T + W+ Sbjct: 343 --RCVSVGARDRTARYWK 358 >5XYI-g nrPDB Length = 335 Score = 29.6 bits (65), Expect = 1.9, Method: Compositional matrix adjust. Identities = 65/338 (19%), Positives = 134/338 (39%), Gaps = 49/338 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH+ + + D ++ + S D+ V+KL++ W + + V+ S Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSR 90 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + ++ S S+D T++LW + S R KL K + V F+P + ++ Sbjct: 91 DASHLLTS-SWDSTLRLW-------DLSTRTTKKL--FLGHKKDVLGVTFSPCN--RRII 138 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +G D +++++ L + + V P A+ SP +AV Sbjct: 139 SVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADET-------------SPLVIAVG 185 Query: 187 ALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + + I+ K+ KL + H S+ + P G+W + TG D ++ + + Sbjct: 186 CWDGKVYIWSIEKEAKL--IKEFKAHDGRCTSVDFTPD-GKW---VITGGSDRKV-VMWL 238 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA---ELQSNLQVELLSEHDD 302 TE ++++ + A Q + T E ++ + Q++L+ + Sbjct: 239 TEN-----GAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFK 293 Query: 303 HNG--------EVWSVSWNLTGTILSSAGDDGKVRLWK 332 H G + ++W G++L S +DG +R W+ Sbjct: 294 HEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWE 331 >5Y88-O nrPDB Length = 451 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 46/222 (20%), Positives = 87/222 (39%), Gaps = 32/222 (14%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V DV ++ + S D+ +K + L+K+ ++ + H S + + Sbjct: 179 AGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKN----QIIRDYYGHLSGVRTVS-IH 233 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 P +IA+A D +KLW+ R + TL KG + V+ P + ++ Sbjct: 234 PTLD-LIATAGRDSVIKLWDM---------RTRIPVITLVGHKGPINQVQCTP--VDPQV 281 Query: 126 ACLGNDGILRLYDALEPSDLRSWT-LTSEMKVLSIPPANHLQSDFCL----SW------C 174 D +RL+D + ++ T ++ ++ P + C SW Sbjct: 282 VSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSL 341 Query: 175 PSRFSPEKLAV----SALEQAIIYQRGKDGKLHVAAKLPGHK 212 + F EK + S + +++ G +G L GHK Sbjct: 342 LTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHK 383 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 19/114 (16%) Query: 26 TCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 85 T S+D +KV+ D + +L + H ++ D A + + S S DKTVK W+ Sbjct: 157 TGSNDTTMKVW----DLATGKLKTTLAGHVMTVR--DVAVSDRHPYLFSVSEDKTVKCWD 210 Query: 86 EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL-ACLGNDGILRLYD 138 + +Q + D G L V+ H L L A G D +++L+D Sbjct: 211 LEKNQ------------IIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWD 252 >5WYJ-BE nrPDB Length = 939 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 2/33 (6%) Query: 53 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 85 H + I A D+ SPE GR I SAS D T++ W+ Sbjct: 583 GHSNRITAFDF-SPE-GRWIVSASLDSTIRTWD 613 >6J6H-n nrPDB Length = 455 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 30/47 (63%), Gaps = 2/47 (4%) Query: 39 DKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 85 D+ + N L ++ H SSI+A+ + P+ + I+S S DKTV++WE Sbjct: 277 DRVSENQGLVQTYDHHLSSILALKYF-PDGSKFISS-SEDKTVRIWE 321 >5YZG-W nrPDB Length = 579 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 49/120 (40%), Gaps = 28/120 (23%) Query: 6 SGHDDLVHDV-VYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWR------AHDSSI 58 SGH V V ++ G + +CS D IK+ WE+ R H ++ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKL---------WEVYGERRCLRTFIGHSKAV 335 Query: 59 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 I + + G SA+YD+ +KLW D + +C R N+ Y VKF P Sbjct: 336 RDICFNTA--GTQFLSAAYDRYLKLW--DTETGQCISRFTNRKVP--------YCVKFNP 383 >6QDV-o nrPDB Length = 513 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 49/120 (40%), Gaps = 28/120 (23%) Query: 6 SGHDDLVHDV-VYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWR------AHDSSI 58 SGH V V ++ G + +CS D IK+ WE+ R H ++ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKL---------WEVYGERRCLRTFIGHSKAV 269 Query: 59 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 I + + G SA+YD+ +KLW D + +C R N+ Y VKF P Sbjct: 270 RDICFNTA--GTQFLSAAYDRYLKLW--DTETGQCISRFTNRKVP--------YCVKFNP 317 >3FCP-A nrPDB Length = 381 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 36/130 (27%), Positives = 58/130 (44%), Gaps = 10/130 (7%) Query: 183 LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCK---DGR 239 A SA+E A++ +GK L V+A L G + W + G + IA G K +GR Sbjct: 104 FAKSAIETALLDAQGKALGLPVSALLGGALQTALPVLWTLASGDTAKDIAEGEKLLAEGR 163 Query: 240 IRIFKITEKLSPLASEESLTNS--NMFDNSADVDMDAQGRSDSNT-----EEKAELQSNL 292 R FK+ LA++ T + + A + +D D+ T E A + +L Sbjct: 164 HRAFKLKIGARELATDLRHTRAIVEALGDRASIRVDVNQAWDAATGAKGCRELAAMGVDL 223 Query: 293 QVELLSEHDD 302 + +S HD+ Sbjct: 224 IEQPVSAHDN 233 >5CXC-A nrPDB Length = 510 Score = 28.9 bits (63), Expect = 3.4, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 1/40 (2%) Query: 300 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEF 339 H H + + + LT L+SAG D VR+WK T S+ F Sbjct: 188 HGGHTASIKAAKF-LTSDRLASAGMDRTVRVWKYTESDHF 226 >3ODT-A nrPDB Length = 313 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 59/141 (41%), Gaps = 20/141 (14%) Query: 14 DVVYDFYGRHVATCS---SDQHIKVFKLDKDTSNWE---LSDSWRAHDSSIVAIDWASPE 67 D +Y G CS D + DK W+ L + +AH++S+ S Sbjct: 95 DPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFS 154 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 + + +AS DKT+KLW+ D + SG ND L A G ++C Sbjct: 155 ENKFL-TASADKTIKLWQNDKVIKTFSGIH-------NDVVRHL-----AVVDDGHFISC 201 Query: 128 LGNDGILRLYDALEPSDLRSW 148 NDG+++L D LR++ Sbjct: 202 -SNDGLIKLVDMHTGDVLRTY 221 >5TF2-A nrPDB Length = 407 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 11/24 (45%), Positives = 16/24 (66%) Query: 310 VSWNLTGTILSSAGDDGKVRLWKA 333 V +N T+L++ G DG VR+WK Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKV 201 >5BJS-A nrPDB Length = 605 Score = 28.5 bits (62), Expect = 4.7, Method: Compositional matrix adjust. Identities = 13/28 (46%), Positives = 18/28 (64%) Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEE 92 SP IIASAS D T+++W P+ E+ Sbjct: 187 SPANPYIIASASDDTTIRIWSLAPEHEK 214 >4JBD-A nrPDB Length = 330 Score = 28.5 bits (62), Expect = 5.1, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 18/32 (56%), Gaps = 3/32 (9%) Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIA 232 + HVA +PGH + I+W G W+ L+A Sbjct: 162 RQHVAVNVPGHGVVHGDIAWG---GNWFFLVA 190 >5WLC-LU nrPDB Length = 489 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 10/27 (37%), Positives = 17/27 (62%) Query: 307 VWSVSWNLTGTILSSAGDDGKVRLWKA 333 V+ V +++ + S DDG VRLW++ Sbjct: 351 VFQVKYSMDSKYIISGSDDGNVRLWRS 377 >5WLC-LJ nrPDB Length = 513 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 13/37 (35%), Positives = 22/37 (59%), Gaps = 3/37 (8%) Query: 207 KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 +L G +R++S+ P+ L+ATG DG IR++ Sbjct: 163 ELTGATDYVRTLSFIPAAP---HLVATGSYDGLIRLY 196 Score = 28.1 bits (61), Expect = 6.5, Method: Compositional matrix adjust. Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 9/71 (12%) Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 +I+A+AS D+ +LW+ + L + + ++ F PA L +A Sbjct: 137 NKILATASDDRVTRLWD--------ISNAYEPQLELTGATDYVRTLSFIPAAPHL-VATG 187 Query: 129 GNDGILRLYDA 139 DG++RLYD Sbjct: 188 SYDGLIRLYDT 198 >5M89-A nrPDB Length = 329 Score = 28.1 bits (61), Expect = 6.2, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 23/36 (63%), Gaps = 2/36 (5%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDG-KVRLW-KATYS 336 GEV S+SW+ TG L++ G G V+++ KAT S Sbjct: 255 QTGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKS 290 >4AEZ-A nrPDB Length = 401 Score = 28.1 bits (61), Expect = 6.5, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 13/54 (24%) Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 175 GL+LA GND +++++DA S + +T T NH + ++WCP Sbjct: 229 GLQLASGGNDNVVQIWDAR--SSIPKFTKT-----------NHNAAVKAVAWCP 269 Score = 28.1 bits (61), Expect = 6.6, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 20/34 (58%) Query: 303 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYS 336 H+ EV ++W G L+S G+D V++W A S Sbjct: 216 HSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSS 249 >6EMK-B nrPDB Length = 303 Score = 27.7 bits (60), Expect = 8.7, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 33/64 (51%), Gaps = 5/64 (7%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTV 81 +H+ATCS+D +V+ +D D ++L + H + D A + +AS D V Sbjct: 220 KHLATCSADHTARVWSIDDD---FKLETTLDGHQRWV--WDCAFSADSAYLVTASSDHYV 274 Query: 82 KLWE 85 +LW+ Sbjct: 275 RLWD 278 >3I2N-A nrPDB Length = 357 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 11/94 (11%) Query: 183 LAVSALEQAIIYQRGKDGKLHV----AAKLP-----GHKSLIRSISWAPSIGRWYQL--I 231 ++L+Q + G LH+ A ++P GHK +I +I +G I Sbjct: 73 FGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEI 132 Query: 232 ATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 265 TG +DG ++++ +K P+A+ E + N D Sbjct: 133 VTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRD 166 >5MSH-B nrPDB Length = 369 Score = 27.3 bits (59), Expect = 9.2, Method: Compositional matrix adjust. Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 9/58 (15%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGIL--RLYDALEPSD-------LRSWTLTSEMKV 156 +GSL KFA + L A G D +L LYD + D LR+ +T ++KV Sbjct: 17 RGSLLDTKFAQTRVLLSKAMAGGDVLLDEYLYDVVNGQDFRATVAFLRTHVITGKIKV 74 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3F3P-A nrPDB 408 e-114 3JRO-A nrPDB 285 2e-77 4YCZ-A nrPDB 276 1e-74 5A9Q-7 nrPDB 264 4e-71 4L9O-A nrPDB 264 6e-71 3JRP-A nrPDB 263 6e-71 3BG0-A nrPDB 263 1e-70 4BZK-B nrPDB 254 3e-68 4BTS-AR nrPDB 233 6e-62 5FL8-q nrPDB 215 2e-56 2HES-X nrPDB 185 3e-47 6EOJ-D nrPDB 176 2e-44 6QX9-5O nrPDB 167 7e-42 3FM0-A nrPDB 160 7e-40 5NNZ-B nrPDB 148 4e-36 3DM0-A nrPDB 147 1e-35 6HQA-B nrPDB 142 2e-34 1VYH-C nrPDB 139 2e-33 5GAN-H nrPDB 134 6e-32 5MZH-A nrPDB 128 4e-30 5WLC-LO nrPDB 113 8e-26 5I2T-A nrPDB 112 3e-25 5OQL-J nrPDB 100 1e-21 Sequences not found previously or not previously below threshold: 6G51-g nrPDB 135 3e-32 6MZM-G nrPDB 133 8e-32 6F3T-A nrPDB 133 9e-32 4V6W-Ag nrPDB 128 4e-30 4V8M-A7 nrPDB 123 7e-29 6HHQ-h nrPDB 120 8e-28 3JAP-g nrPDB 120 9e-28 5M25-A nrPDB 119 1e-27 5OPT-p nrPDB 116 1e-26 5XYI-g nrPDB 116 2e-26 2H9P-A nrPDB 113 1e-25 6QX9-4B nrPDB 110 9e-25 4V7E-Bg nrPDB 107 7e-24 6N9G-C nrPDB 103 2e-22 5YZG-W nrPDB 102 3e-22 6QDV-o nrPDB 102 3e-22 5WYJ-BC nrPDB 101 4e-22 6GMH-W nrPDB 101 6e-22 6ID0-T nrPDB 99 3e-21 3MKQ-A nrPDB 99 3e-21 3JB9-L nrPDB 98 5e-21 5UZ7-B nrPDB 98 7e-21 2YNP-A nrPDB 96 2e-20 5Y88-O nrPDB 95 3e-20 5K0Y-T nrPDB 92 4e-19 4U1E-I nrPDB 90 1e-18 4XFV-A nrPDB 90 2e-18 3CFV-B nrPDB 90 2e-18 5Z56-q nrPDB 90 2e-18 3C9C-A nrPDB 89 2e-18 5Y1U-A nrPDB 89 3e-18 5K1B-B nrPDB 89 4e-18 5WJC-A nrPDB 88 6e-18 6Q8F-A nrPDB 87 8e-18 5WLC-LU nrPDB 87 1e-17 5FVM-C nrPDB 87 1e-17 4LG8-A nrPDB 86 2e-17 6EMK-B nrPDB 85 3e-17 1NR0-A nrPDB 85 4e-17 5L9T-R nrPDB 85 4e-17 5WYK-BB nrPDB 85 5e-17 4J0W-A nrPDB 84 1e-16 4XYI-A nrPDB 83 2e-16 3JB9-g nrPDB 82 5e-16 5OQL-L nrPDB 81 7e-16 5NZU-C nrPDB 81 8e-16 5OQL-d nrPDB 80 1e-15 6ELZ-p nrPDB 80 2e-15 2AQ5-A nrPDB 79 3e-15 6BX3-A nrPDB 75 3e-14 5WLC-LJ nrPDB 74 8e-14 4AEZ-A nrPDB 74 1e-13 4A11-B nrPDB 71 6e-13 2PM9-A nrPDB 71 8e-13 6BX3-B nrPDB 70 1e-12 6CHG-A nrPDB 70 1e-12 5N4A-A nrPDB 70 1e-12 3ODT-A nrPDB 70 1e-12 5FA5-B nrPDB 70 2e-12 4OWR-A nrPDB 69 2e-12 3W15-A nrPDB 69 3e-12 6J6H-n nrPDB 69 3e-12 5G04-R nrPDB 69 4e-12 6F1U-h nrPDB 68 6e-12 5CXC-A nrPDB 68 7e-12 4GGA-A nrPDB 67 1e-11 6CB1-s nrPDB 67 1e-11 6C0F-s nrPDB 67 1e-11 5LCW-Q nrPDB 67 1e-11 6EM1-m nrPDB 67 1e-11 5A31-R nrPDB 66 2e-11 5WLC-LS nrPDB 66 2e-11 4N14-A nrPDB 65 5e-11 4BH6-A nrPDB 65 6e-11 5OQL-X nrPDB 63 2e-10 3ACP-A nrPDB 63 2e-10 4G56-B nrPDB 62 3e-10 5K19-A nrPDB 62 4e-10 6E29-D nrPDB 62 5e-10 4PSX-B nrPDB 60 1e-09 5A9Q-2 nrPDB 60 2e-09 5BJS-A nrPDB 60 2e-09 5OV3-A nrPDB 60 2e-09 5MWJ-A nrPDB 60 2e-09 3DWL-C nrPDB 60 2e-09 5WBU-D nrPDB 59 2e-09 3I2N-A nrPDB 58 4e-09 2P9P-C nrPDB 57 1e-08 3JZG-A nrPDB 56 2e-08 5CXB-B nrPDB 55 6e-08 5A9Q-0 nrPDB 54 7e-08 5YZG-2 nrPDB 53 1e-07 5WYJ-BE nrPDB 52 4e-07 4E5Z-B nrPDB 52 4e-07 6CHG-D nrPDB 52 4e-07 3DW8-B nrPDB 51 9e-07 4J0X-A nrPDB 50 1e-06 5WLC-SG nrPDB 50 1e-06 5TF2-A nrPDB 49 3e-06 1PI6-A nrPDB 48 4e-06 5WLC-LN nrPDB 47 9e-06 5MC6-j nrPDB 46 3e-05 5AMS-A nrPDB 45 4e-05 5WLC-LH nrPDB 43 2e-04 4FHN-A nrPDB 41 7e-04 3EI3-B nrPDB 41 8e-04 4AV8-A nrPDB 40 0.001 6IYY-A nrPDB 37 0.010 5M89-A nrPDB 37 0.011 2VDU-B nrPDB 36 0.022 5WLC-LW nrPDB 35 0.034 6CVZ-A nrPDB 35 0.038 5LTD-A nrPDB 35 0.053 5CWW-B nrPDB 33 0.13 2I3T-A nrPDB 33 0.15 1XFK-A nrPDB 31 1.0 6N8P-A nrPDB 30 1.2 3ZYZ-A nrPDB 28 7.1 >3F3P-A nrPDB Length = 351 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 349/349 (100%), Positives = 349/349 (100%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI Sbjct: 183 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 242 Query: 241 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 300 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH Sbjct: 243 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 302 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ Sbjct: 303 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 351 >3JRO-A nrPDB Length = 753 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 81/359 (22%), Positives = 148/359 (41%), Gaps = 74/359 (20%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET--HKLIDTLTGHEGPVWR 58 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 111 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L +DG + + + E I H SW P+ Sbjct: 112 YGPLLLVASSDGKVSVVEFKENGTTSP-----------IIIDAHAIGVNSASWAPATIEE 160 Query: 181 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSIGRWY 228 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLR 219 Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 +A+ +D I+ + P Sbjct: 220 SYLASVSQDRTCIIWTQDNEQGPW------------------------------------ 243 Query: 289 QSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 347 + L + + +W SW+L+G +L+ +G D KV LWK +++ + Sbjct: 244 -----KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 >4YCZ-A nrPDB Length = 876 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 100/362 (27%), Positives = 160/362 (44%), Gaps = 84/362 (23%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 +SGHDD++HD V D+YGR +ATCSSD+ IK+F+++ +T L+++ + HD ++ + Sbjct: 11 VIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQ--RLTETLKGHDGAVWCV 68 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 WA P+YG I+ASA YD V +W E W ++ K S+ V ++P Sbjct: 69 SWAHPKYGNILASAGYDGKVLIWRE-------LNGAWQRIFDFALHKASVNVVSWSPHEA 121 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 G LAC +DG + + + + SW SI A H +SW P+ SP Sbjct: 122 GCLLACASSDGNVSVLEFRDN----SWE-------HSIFHA-HGLGVNSVSWAPAT-SPG 168 Query: 182 KLAVSALEQAIIYQR-----GKDGKLHVAA-------------KLPGHKSLIRSISWAPS 223 + S R G D L + A L GH +R ++W+P+ Sbjct: 169 SIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPT 228 Query: 224 IGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTE 283 + + IA+ +D +RI+ ++ Sbjct: 229 VLQ-KSYIASASEDRTVRIWT-------------------------------------SD 250 Query: 284 EKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMS 343 LQ N +V + + VW VSW+L+G +L+++G D KV LWK E++C+ Sbjct: 251 PANPLQWNCKVL------NFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVK 304 Query: 344 VI 345 I Sbjct: 305 TI 306 >5A9Q-7 nrPDB Length = 360 Score = 264 bits (673), Expect = 4e-71, Method: Composition-based stats. Identities = 119/355 (33%), Positives = 190/355 (53%), Gaps = 55/355 (15%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 + H DL+HDV +DF+GR +ATCSSDQ +KV+ ++ +W + SW+ H S+ + W Sbjct: 7 IAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTW 65 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGR---RWNKLCTLNDSKGSLYSVKFAPAH 120 A PE+G+++AS S+D+T +WEE + R W K TL DS+ S+ VKFAP H Sbjct: 66 AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKH 125 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP--SRF 178 +GL LA DGI+R+Y+A + +L W+L E+ S C+SW P SR Sbjct: 126 MGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC--------KLSCSCISWNPSSSRA 177 Query: 179 SPEKLAVS-------ALEQAIIYQRGKDGKLHVAA-KLPGHKSLIRSISWAPSIGRWYQL 230 +AV A+ + I++ ++ + + A L + I++AP++GR + + Sbjct: 178 HSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHI 237 Query: 231 IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQS 290 +A KD +RIF L P+ E + + + Sbjct: 238 LAIATKD--VRIFT----LKPVRKELTSSGG---------------------------PT 264 Query: 291 NLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 ++ ++++ D+HN +VW VSWN+TGT+L+S+GDDG VRLWKA Y + +KC ++ Sbjct: 265 KFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319 >4L9O-A nrPDB Length = 349 Score = 264 bits (673), Expect = 6e-71, Method: Composition-based stats. Identities = 88/350 (25%), Positives = 143/350 (40%), Gaps = 66/350 (18%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 + HDDL+HD V D+YGR +ATCSSD+ IK+F++D + N L ++ H+ + + Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGE--NQRLVETLIGHEGPVWQV 119 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 WA P++G I+AS SYD V +W+ED WNK+ + + S+ SV +AP Sbjct: 120 AWAHPKFGVILASCSYDGKVLIWKED-------NGVWNKVAEHSVHQASVNSVSWAPHEY 172 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF--S 179 G L C +DG + + + + L + H SW P + Sbjct: 173 GPVLLCASSDGKISIVEFKDGGALEPIVIQG-----------HAIGVNAASWAPISLPDN 221 Query: 180 PEKLAVSALEQAI-IYQRGKDGKLHVAAK-LPGHKSLIRSISWAPSIGRWYQLIATGCKD 237 + + + I++ K + + GH +R ++W+PS IAT +D Sbjct: 222 TRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSR-LSKSYIATASQD 280 Query: 238 GRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELL 297 + I+ K SN EK L Sbjct: 281 RTVLIWTKDGK-------------------------------SNKWEKQPLTK------- 302 Query: 298 SEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 347 + W SW+L+G +L+ +G D KV LWK +++ + Sbjct: 303 ---EKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEVDQ 349 >3JRP-A nrPDB Length = 379 Score = 263 bits (672), Expect = 6e-71, Method: Composition-based stats. Identities = 81/359 (22%), Positives = 148/359 (41%), Gaps = 74/359 (20%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 3 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET--HKLIDTLTGHEGPVWR 60 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 113 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L +DG + + + E I H SW P+ Sbjct: 114 YGPLLLVASSDGKVSVVEFKENGTTSP-----------IIIDAHAIGVNSASWAPATIEE 162 Query: 181 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSIGRWY 228 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 163 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLR 221 Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 +A+ +D I+ + P Sbjct: 222 SYLASVSQDRTCIIWTQDNEQGPW------------------------------------ 245 Query: 289 QSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 347 + L + + +W SW+L+G +L+ +G D KV LWK +++ + Sbjct: 246 -----KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 >3BG0-A nrPDB Length = 316 Score = 263 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 98/364 (26%), Positives = 154/364 (42%), Gaps = 76/364 (20%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 + D+ H+D++HD D+YG +ATCSSD+ +K+F + L R H+ + Sbjct: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRN--GGQILIADLRGHEGPVWQ 62 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + WA P YG I+AS SYD+ V +W E+ W K S+ SV +AP Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREE-------NGTWEKSHEHAGHDSSVNSVCWAPHD 115 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 GL LAC +DG + L ++T + +V I A H +SW P+ Sbjct: 116 YGLILACGSSDGAISLL---------TYTGEGQWEVKKINNA-HTIGCNAVSWAPAVVPG 165 Query: 181 --------------EKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 225 ++ A + I +++ +DG+ KL H +R ++WAPSIG Sbjct: 166 SLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIG 225 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 IA+ +DGR+ I+ + S Sbjct: 226 LPTSTIASCSQDGRVFIWTCDDASS----------------------------------- 250 Query: 286 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 + +LL + N VW VSW++T IL+ +G D KV LWK + ++ C+S + Sbjct: 251 ----NTWSPKLLHK---FNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDV 303 Query: 346 TAQQ 349 Q Sbjct: 304 NKGQ 307 >4BZK-B nrPDB Length = 297 Score = 254 bits (649), Expect = 3e-68, Method: Composition-based stats. Identities = 81/359 (22%), Positives = 148/359 (41%), Gaps = 74/359 (20%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H++L+HD V D+YG+ +ATCSSD+ IK+F+++ +T +L D+ H+ + Sbjct: 1 MVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGET--HKLIDTLTGHEGPVWR 58 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +DWA P++G I+AS SYD V +W+E+ RW+++ S+ SV++AP Sbjct: 59 VDWAHPKFGTILASCSYDGKVLIWKEE-------NGRWSQIAVHAVHSASVNSVQWAPHE 111 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L +DG + + + E I H SW P+ Sbjct: 112 YGPLLLVASSDGKVSVVEFKENGTTSP-----------IIIDAHAIGVNSASWAPATIEE 160 Query: 181 E----------KLAVSALEQAI-IYQRGKDGKLHV-AAKLPGHKSLIRSISWAPSIGRWY 228 + K + + I++ D + +V + L GH +R ++W+P++ Sbjct: 161 DGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTV-LLR 219 Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 +A+ +D I+ + P Sbjct: 220 SYLASVSQDRTCIIWTQDNEQGPW------------------------------------ 243 Query: 289 QSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 347 + L + + +W SW+L+G +L+ +G D KV LWK +++ + Sbjct: 244 -----KKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 >4BTS-AR nrPDB Length = 343 Score = 233 bits (594), Expect = 6e-62, Method: Composition-based stats. Identities = 75/348 (21%), Positives = 140/348 (40%), Gaps = 57/348 (16%) Query: 7 GHDDLVHDVVYDFYGRH------VATCSSDQHIKVFKLDKDTSNWELSDSWR---AHDSS 57 GH D V +V F + + + S D+ + ++KL ++ N + H+ Sbjct: 19 GHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHF 78 Query: 58 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA 117 + D A + S+S+DKT++LW+ +G + + + +YSV F+ Sbjct: 79 VS--DLALSQENCFAISSSWDKTLRLWDLR------TGTTYKRFV---GHQSEVYSVAFS 127 Query: 118 PAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSR 177 P + ++ A +++ W + E K S NH C+ + P Sbjct: 128 PDNR-------------QILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIM 174 Query: 178 FSPEKLAVSALEQAIIYQRGKDGKLHVA-------AKLPGHKSLIRSISWAPSIGRWYQL 230 S K+ A A + G DG+L V H+S + +S +P+ G++ Sbjct: 175 KSANKVQPFAPYFASV---GWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPN-GKY--- 227 Query: 231 IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS------NTEE 284 IATG KD ++ I+ I P ++ + N + + A G T+ Sbjct: 228 IATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQS 287 Query: 285 KAELQSNLQVELLSEHDDHNG---EVWSVSWNLTGTILSSAGDDGKVR 329 KA + ++ E +++ + G + S++WN G L + DG +R Sbjct: 288 KAPV-CTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIR 334 Score = 73.5 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 33/243 (13%), Positives = 79/243 (32%), Gaps = 26/243 (10%) Query: 100 KLCTLNDSKGSLYSV----KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMK 155 K L + S+ L D + ++ E + + Sbjct: 13 KRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPH--- 69 Query: 156 VLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLI 215 ++ NH SD LS + + ++ S + ++ + GH+S + Sbjct: 70 -KALTGHNHFVSDLALS----QENCFAISSSWDKTLRLWDLRTGTTYK---RFVGHQSEV 121 Query: 216 RSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQ 275 S++++P + I + + I+++ I + ++E+ + + M + Sbjct: 122 YSVAFSPDN----RQILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSA 177 Query: 276 G-------RSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKV 328 S + N ++ H V +S + G +++ G D K+ Sbjct: 178 NKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKL 237 Query: 329 RLW 331 +W Sbjct: 238 LIW 240 Score = 50.0 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 23/194 (11%), Positives = 61/194 (31%), Gaps = 26/194 (13%) Query: 162 ANHLQSDFCLSWCPS---RFSPEKLAVSALEQAI----IYQRGKDGKLHVAAK-LPGHKS 213 H + S L + ++ + +Y+ ++G + K L GH Sbjct: 18 EGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNH 77 Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMD 273 + ++ + + + D +R++ + + + S D Sbjct: 78 FVSDLALS----QENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQI 133 Query: 274 AQGRSDSNTEEKAEL-QSNLQVELLSEHDDHNGEVWSVSWNLT----------GTILSSA 322 ++ + L + +E ++H+ V V ++ +S Sbjct: 134 LSAGAEREIKLWNILGECKFSS---AEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASV 190 Query: 323 GDDGKVRLWKATYS 336 G DG++++W + Sbjct: 191 GWDGRLKVWNTNFQ 204 >5FL8-q nrPDB Length = 515 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 71/396 (17%), Positives = 143/396 (36%), Gaps = 92/396 (23%) Query: 6 SGHDDLVHDVVYDFY-GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 +GH + + + + T + D +++ D T + + H + ++ + W+ Sbjct: 140 AGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMH----TLKGHYNWVLCVSWS 195 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL--- 121 G +IA+ S D T++LW+ P +C G L + S+ + P HL Sbjct: 196 PD--GEVIATGSMDNTIRLWD--PKSGQCLGD------ALRGHSKWITSLSWEPIHLVKP 245 Query: 122 --GLKLACLGNDGILRLYDAL------------------------------EPSDLRSWT 149 +LA DG ++++D + +R W Sbjct: 246 GSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWD 305 Query: 150 LTSEMKVLSIPPAN-------HLQSDFCLSWCPSR------FSPEKLAVSALEQ--AIIY 194 + S+ + ++I ++ L +D+ L +PE+ ALE I Sbjct: 306 INSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICK 365 Query: 195 QRGKDGKLHVAA-------------------KLPGHKSLIRSISWAPSIGRWYQLIATGC 235 + G ++ V A ++ GH+ L+ ++++P + I + Sbjct: 366 KNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPD----GRYIVSAS 421 Query: 236 KDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 295 D I+++ + + + S+D + D+ + L V+ Sbjct: 422 FDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVD 481 Query: 296 LLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 L H EV++V W++ G + S G D VRLW Sbjct: 482 L----PGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 70.8 bits (171), Expect = 8e-13, Method: Composition-based stats. Identities = 48/279 (17%), Positives = 88/279 (31%), Gaps = 30/279 (10%) Query: 43 SNWELSDSWRAHDSSIVAIDWASPEYGRII---ASASYDKTVKLWEEDPDQEECSGRRWN 99 + + + + ID Y +I +++ D+ L+ + R + Sbjct: 77 YTFSCTIQGKKASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSS 136 Query: 100 KLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSI 159 + ++ FAP H ++ D R++D + M L Sbjct: 137 --SAIAGHGSTILCSAFAP-HTSSRMVTGAGDNTARIWDC---------DTQTPMHTLK- 183 Query: 160 PPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSIS 219 H C+SW P E +A +++ I K G+ A L GH I S+S Sbjct: 184 ---GHYNWVLCVSWSP---DGEVIATGSMDNTIRLWDPKSGQCLGDA-LRGHSKWITSLS 236 Query: 220 WAPSIG---RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQG 276 W P +A+ KDG I+I+ ++ + + + G Sbjct: 237 WEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQ-GLLYSG 295 Query: 277 RSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT 315 D N Q ++ H V +S + Sbjct: 296 SHDRTVRVWDI---NSQGRCINILKSHAHWVNHLSLSTD 331 >2HES-X nrPDB Length = 330 Score = 185 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 109/247 (44%), Gaps = 21/247 (8%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 + GH++ V V + G ++ATCS D+ + +++ D+ +E + H + Sbjct: 99 LLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKH 158 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + W E ++AS+SYD TV++W++ D EC + LN +G+++S F Sbjct: 159 VIWHPSE--ALLASSSYDDTVRIWKDYDDDWEC-------VAVLNGHEGTVWSSDFDKTE 209 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 +L +D +R++ + + E +I P H + + ++W F+ Sbjct: 210 GVFRLCSGSDDSTVRVWKYMGDDE----DDQQEWVCEAILPDVHKRQVYNVAWG---FNG 262 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAK--LPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 +V A +Y+ DG+ V AK L I + W G+ ++ATG DG Sbjct: 263 LIASVGADGVLAVYEE-VDGEWKVFAKRALCHGVYEINVVKWLELNGK--TILATGGDDG 319 Query: 239 RIRIFKI 245 + + + Sbjct: 320 IVNFWSL 326 Score = 99.3 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 119/327 (36%), Gaps = 32/327 (9%) Query: 16 VYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASA 75 +DF +AT S+D+ IK+ + D AH +I ++ W ++A+ Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHT--SLLAAG 76 Query: 76 SYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILR 135 S+D TV +W ++ + + L + + + V ++ + G LA D + Sbjct: 77 SFDSTVSIWAKEESADRTF--EMDLLAIIEGHENEVKGVAWS--NDGYYLATCSRDKSVW 132 Query: 136 LYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQ 195 +++ E + E + +S+ H Q + W PS + S + I++ Sbjct: 133 IWETDESGE--------EYECISVLQE-HSQDVKHVIWHPS--EALLASSSYDDTVRIWK 181 Query: 196 RGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLA-- 253 D A L GH+ + S + + G + + +G D +R++K Sbjct: 182 -DYDDDWECVAVLNGHEGTVWSSDFDKTEGVFR--LCSGSDDSTVRVWKYMGDDEDDQQE 238 Query: 254 -------SEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 + + + A +D E+ +V E Sbjct: 239 WVCEAILPDVHKRQVYNVAWGFN-GLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYE 297 Query: 307 VWSVSW-NLTGT-ILSSAGDDGKVRLW 331 + V W L G IL++ GDDG V W Sbjct: 298 INVVKWLELNGKTILATGGDDGIVNFW 324 Score = 82.4 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 116/304 (38%), Gaps = 35/304 (11%) Query: 47 LSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLND 106 L S + + I + D++ I+A+ S D+ +KL D + Sbjct: 6 LIKSLKLYKEKIWSFDFS----QGILATGSTDRKIKLVSVKYDDF-----TLIDVLDETA 56 Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 K ++ SV + P LA D + ++ A E S R++ + L H Sbjct: 57 HKKAIRSVAWRPHT--SLLAAGSFDSTVSIW-AKEESADRTFEMD-----LLAIIEGHEN 108 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLH-VAAKLPGHKSLIRSISWAPSIG 225 ++W S S + I++ + G+ + + L H ++ + W PS Sbjct: 109 EVKGVAW--SNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPS-- 164 Query: 226 RWYQLIATGCKDGRIRIFKITEK----LSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 281 L+A+ D +RI+K + ++ L E S+ FD + V G DS Sbjct: 165 --EALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDST 222 Query: 282 TEEKAELQSNLQVELLSEHDD-----HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYS 336 + + + + H +V++V+W G +++S G DG + +++ Sbjct: 223 VRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEE-VD 280 Query: 337 NEFK 340 E+K Sbjct: 281 GEWK 284 Score = 76.6 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 35/148 (23%), Positives = 61/148 (41%), Gaps = 12/148 (8%) Query: 209 PGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS-------EESLTNS 261 HK IRS++W P L+A G D + I+ E E Sbjct: 55 TAHKKAIRSVAWRP----HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEV 110 Query: 262 NMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSS 321 S D A D + +S + E +S +H+ +V V W+ + +L+S Sbjct: 111 KGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLAS 170 Query: 322 AGDDGKVRLWKATYSNEFKCMSVITAQQ 349 + D VR+WK Y ++++C++V+ + Sbjct: 171 SSYDDTVRIWK-DYDDDWECVAVLNGHE 197 Score = 69.3 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 42/260 (16%), Positives = 91/260 (35%), Gaps = 36/260 (13%) Query: 101 LCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP 160 + +L K ++S F+ LA D ++L + + Sbjct: 7 IKSLKLYKEKIWSFDFSQG----ILATGSTDRKIKLVSVKYDDFT---------LIDVLD 53 Query: 161 PANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDG----KLHVAAKLPGHKSLIR 216 H ++ ++W P + A S I+ + + ++ + A + GH++ ++ Sbjct: 54 ETAHKKAIRSVAWRP--HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVK 111 Query: 217 SISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNM----FDNSADVDM 272 ++W+ +AT +D + I++ E L + + Sbjct: 112 GVAWSND----GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEAL 167 Query: 273 DAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTI--LSSAGDDGKVRL 330 A D + + + ++ + H G VWS ++ T + L S DD VR+ Sbjct: 168 LASSSYDDTVRIWKDYDDDWE--CVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRV 225 Query: 331 WK-----ATYSNEFKCMSVI 345 WK E+ C +++ Sbjct: 226 WKYMGDDEDDQQEWVCEAIL 245 Score = 32.3 bits (71), Expect = 0.28, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 32/81 (39%), Gaps = 3/81 (3%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFK-LDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H V++V + F G +A+ +D + V++ +D + + I + W Sbjct: 249 HKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHG-VYEINVVKWLEL 306 Query: 67 EYGRIIASASYDKTVKLWEED 87 I+A+ D V W + Sbjct: 307 NGKTILATGGDDGIVNFWSLE 327 >6EOJ-D nrPDB Length = 470 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 113/305 (37%), Gaps = 42/305 (13%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 D+ H + + D+ + TCS D +K++ SN + H + + DW Sbjct: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF----SNGKQERVLSGHHWDVKSCDW 227 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 PE G +IASAS D VKLW+ P C + ++ K ++ +F P L Sbjct: 228 -HPEMG-LIASASKDNLVKLWD--PRSGNC-------ISSILKFKHTVLKTRFQPTKGNL 276 Query: 124 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDF-CLSWCPSRFSPEK 182 +A + D R++D +++ M V ++D+ L W P S Sbjct: 277 LMA-ISKDKSCRVFDI-------RYSMKELMCVRD-------ETDYMTLEWHPINESMFT 321 Query: 183 LAV--SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 LA +L+ + Q + L + H I S+S+ P + AT KD I Sbjct: 322 LACYDGSLKHFDLLQNLNEPILTIPY---AHDKCITSLSYNPV----GHIFATAAKDRTI 374 Query: 241 RIFKITEKLSPLASEESLTNSNMFD--NSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 R + + P A ++ N+ + + R S + L+ L Sbjct: 375 RFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALP 434 Query: 299 EHDDH 303 + Sbjct: 435 NMNGF 439 Score = 81.2 bits (198), Expect = 6e-16, Method: Composition-based stats. Identities = 48/321 (14%), Positives = 109/321 (33%), Gaps = 40/321 (12%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRI 71 + + + GR + + ++ S++ +AHDS++ + ++ Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLWN----ASSFTFETLMQAHDSAVTTMKYSHD--SDW 149 Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGND 131 + S D +K+W+ + + S+ + F+ +D Sbjct: 150 MISGDADGMIKIWQPNFSMVK---------EIDAAHTESIRDMAFSSNDSKF--VTCSDD 198 Query: 132 GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQA 191 IL++++ R + +H C W P +A ++ + Sbjct: 199 NILKIWNFSNGKQER------------VLSGHHWDVKSC-DWHP---EMGLIASASKDNL 242 Query: 192 IIYQRGKDGKL-HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLS 250 + + D + + + + K + + P+ G I KD R+F I + Sbjct: 243 V---KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI---SKDKSCRVFDIRYSMK 296 Query: 251 PLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSV 310 L T+ + + + + +L NL +L+ H+ + S+ Sbjct: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 Query: 311 SWNLTGTILSSAGDDGKVRLW 331 S+N G I ++A D +R W Sbjct: 357 SYNPVGHIFATAAKDRTIRFW 377 Score = 36.5 bits (82), Expect = 0.018, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 16/36 (44%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVF 36 + HD + + Y+ G AT + D+ I+ + Sbjct: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 30.4 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 7/73 (9%), Positives = 22/73 (30%), Gaps = 4/73 (5%) Query: 264 FDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG 323 + + + + H+ V ++ ++ + S Sbjct: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLM----QAHDSAVTTMKYSHDSDWMISGD 154 Query: 324 DDGKVRLWKATYS 336 DG +++W+ +S Sbjct: 155 ADGMIKIWQPNFS 167 >6QX9-5O nrPDB Length = 357 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 125/329 (37%), Gaps = 46/329 (13%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH+ V+ + G +A+ D+ I ++ + D N+ + + H +++ + + + Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNY---ATLKGHSGAVMELHYNT 119 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G ++ SAS DKTV +W+ + +G R +L S Y PA G +L Sbjct: 120 D--GSMLFSASTDKTVAVWDSE------TGERVKRLKGHTSFVNSCY-----PARRGPQL 166 Query: 126 AC-LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 C +DG ++L+D + + ++++ T ++ ++ + +++ Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND-----------------TSDQII 209 Query: 185 VSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 ++ I ++ ++ + + GH + +S + + + D +R++ Sbjct: 210 SGGIDNDIKVWDLRQN---KLTYTMRGHADSVTGLSLS----SEGSYLLSNAMDNTVRVW 262 Query: 244 KITE--KLSPLASEESLTNSNMFDNSADVDMDAQGRS--DSNTEEKAELQSNLQVELLSE 299 + N N G + + + +L + Sbjct: 263 DVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYK 322 Query: 300 HDDHNGEVWSVSWNLTGTILSSAGDDGKV 328 H G + V+++ I+ SA D ++ Sbjct: 323 LPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 35/288 (12%), Positives = 90/288 (31%), Gaps = 38/288 (13%) Query: 51 WRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGS 110 H+ + + G +ASA +D+ + LW D + TL G+ Sbjct: 62 LSGHEGEVYCCKFHPN--GSTLASAGFDRLILLWNVYGDCDN--------YATLKGHSGA 111 Query: 111 LYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFC 170 + + + G L D + ++D+ ++ + + C Sbjct: 112 VMELHYNTD--GSMLFSASTDKTVAVWDSETGERVKR------------LKGHTSFVNSC 157 Query: 171 LSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQL 230 P+R P+ + + + + + D + A + + + ++++ + Sbjct: 158 ---YPARRGPQLVCTGSDDGTV---KLWDIRKKAAIQTFQNTYQVLAVTFNDT----SDQ 207 Query: 231 IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQS 290 I +G D I+++ + + + S++ D+ Sbjct: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267 Query: 291 NLQVELLSEHDD----HNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 + + + SW+ G+ +++ D V +W T Sbjct: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTT 315 Score = 75.8 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 45/231 (19%), Positives = 81/231 (35%), Gaps = 27/231 (11%) Query: 101 LCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP 160 + L+ +G +Y KF P G LA G D ++ L++ D Sbjct: 59 IMLLSGHEGEVYCCKFHPN--GSTLASAGFDRLILLWNVYGDCDNY------------AT 104 Query: 161 PANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISW 220 H + L + + S + ++ ++ +L GH S + S Sbjct: 105 LKGHSGAVMELHYN--TDGSMLFSASTDKTVAVWDSETGERVK---RLKGHTSFVNS--- 156 Query: 221 APSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 R QL+ TG DG ++++ I +K + + + + D G D+ Sbjct: 157 CYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT-YQVLAVTFNDTSDQIISGGIDN 215 Query: 281 NTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + + Q+ L H V +S + G+ L S D VR+W Sbjct: 216 DIKVWDLRQNK----LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW 262 >3FM0-A nrPDB Length = 345 Score = 160 bits (404), Expect = 7e-40, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 108/251 (43%), Gaps = 26/251 (10%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH++ V V + G +ATCS D+ + V+++D++ +E +H + + W Sbjct: 103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE-DEYECVSVLNSHTQDVKHVVWHPS 161 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + ++ASASYD TVKL+ E+ D C TL + +++S+ F P+ G +LA Sbjct: 162 Q--ELLASASYDDTVKLYREEEDDWVCC-------ATLEGHESTVWSLAFDPS--GQRLA 210 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTS---EMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 +D +R++ P + + + K + H ++ + ++WC + + Sbjct: 211 SCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC--QLTGALA 268 Query: 184 AVSALEQAIIYQR--GKDGKLHVAAKL----PGHKSLIRSISWAPSIGRWYQLIATGCKD 237 + ++Q D + + H + ++W P + L+A+ D Sbjct: 269 TACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNP---KEPGLLASCSDD 325 Query: 238 GRIRIFKITEK 248 G + +K Sbjct: 326 GEVAFWKYQRP 336 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 134/341 (39%), Gaps = 53/341 (15%) Query: 15 VVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSW-RAHDSSIVAIDWASPEYGRIIA 73 + ++ G +A+C D+ I+++ + D+ W H ++ + W+ G +A Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDS--WICKSVLSEGHQRTVRKVAWSP--CGNYLA 77 Query: 74 SASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGI 133 SAS+D T +W+++ D EC + TL + + SV +AP+ G LA D Sbjct: 78 SASFDATTCIWKKNQDDFEC-------VTTLEGHENEVKSVAWAPS--GNLLATCSRDKS 128 Query: 134 LRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAII 193 + +++ E E + +S+ + H Q + W P S E LA ++ + + Sbjct: 129 VWVWEVDEED---------EYECVSVLNS-HTQDVKHVVWHP---SQELLASASYDDTVK 175 Query: 194 YQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT------- 246 R ++ A L GH+S + S+++ PS Q +A+ D +RI++ Sbjct: 176 LYREEEDDWVCCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQG 231 Query: 247 ---EKLSPL------ASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELL 297 P S A D E ++ + Sbjct: 232 VACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPT 291 Query: 298 -----SEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWK 332 H H+ +V V+WN +L+S DDG+V WK Sbjct: 292 FSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332 Score = 97.4 bits (240), Expect = 8e-21, Method: Composition-based stats. Identities = 42/202 (20%), Positives = 84/202 (41%), Gaps = 18/202 (8%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 + H V VV+ +A+ S D +K+++ ++ +W + H+S++ ++ Sbjct: 143 VSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR--EEEDDWVCCATLEGHESTVWSL 200 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEE----CSGR--RWNKLCTLND-SKGSLYSV 114 + G+ +AS S D+TV++W + E CSG W +CTL+ ++Y + Sbjct: 201 AFDPS--GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDI 258 Query: 115 KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 + L AC D +R++ SD + T + H Q C++W Sbjct: 259 AWCQLTGALATACG--DDAIRVFQEDPNSDPQQPTFSLTAH----LHQAHSQDVNCVAWN 312 Query: 175 PSRFSPEKLAVSALEQAIIYQR 196 P + + S + ++ Sbjct: 313 P-KEPGLLASCSDDGEVAFWKY 333 Score = 96.2 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 94/254 (37%), Gaps = 36/254 (14%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 + + + PA G LA G D +R++ S S+ H ++ Sbjct: 16 DSRCWFLAWNPA--GTLLASCGGDRRIRIWGTEGDS----------WICKSVLSEGHQRT 63 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW 227 ++W P LA ++ + + L GH++ ++S++WAPS Sbjct: 64 VRKVAWSPC---GNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS---- 116 Query: 228 YQLIATGCKDGRIRIFKITEKLS---PLASEESLTNSNMFDNSADVDMDAQGRSDSNTEE 284 L+AT +D + ++++ E+ + ++ A D + Sbjct: 117 GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176 Query: 285 KAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNE------ 338 E + + + + H VWS++++ +G L+S DD VR+W+ Sbjct: 177 YREEEDDWV--CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVAC 234 Query: 339 ------FKCMSVIT 346 +KC+ ++ Sbjct: 235 SGSDPSWKCICTLS 248 Score = 70.4 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 31/133 (23%), Positives = 58/133 (43%), Gaps = 9/133 (6%) Query: 218 ISWAPSIGRWYQLIATGCKDGRIRIFKITEKL---SPLASEESLTNSNMFDNSADVDMDA 274 ++W P L+A+ D RIRI+ + SE S + A Sbjct: 22 LAWNP----AGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLA 77 Query: 275 QGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 D+ T + Q + + ++ + H EV SV+W +G +L++ D V +W+ Sbjct: 78 SASFDATTCIWKKNQDDFE--CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD 135 Query: 335 YSNEFKCMSVITA 347 +E++C+SV+ + Sbjct: 136 EEDEYECVSVLNS 148 Score = 45.0 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 18/55 (32%), Positives = 29/55 (52%), Gaps = 2/55 (3%) Query: 296 LLSEHDDHNGE-VWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 LL H W ++WN GT+L+S G D ++R+W T + + C SV++ Sbjct: 7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIW-GTEGDSWICKSVLSEGH 60 >5NNZ-B nrPDB Length = 415 Score = 148 bits (372), Expect = 4e-36, Method: Composition-based stats. Identities = 59/327 (18%), Positives = 116/327 (35%), Gaps = 44/327 (13%) Query: 7 GHDDLVHDVVYD-FYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 GH ++V+ + ++ YG +AT S D+ K++ ++ + ++R H + IV + + Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET----GKCYHTFRGHTAEIVCLSFNP 187 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 ++A+ S D T KLW+ +E + TL + S+ F G ++ Sbjct: 188 --QSTLVATGSMDTTAKLWDIQNGEE---------VYTLRGHSAEIISLSF--NTSGDRI 234 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 D + ++DA + + +S + + Sbjct: 235 ITGSFDHTVVVWDADTGRKVNIL----------------IGHCAEISSASFNWDCSLILT 278 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 ++++ + A L GH I + + +LIAT DG RIF Sbjct: 279 GSMDK--TCKLWDATNGKCVATLTGHDDEILDSCFDYT----GKLIATASADGTARIFSA 332 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNG 305 + E + + + G SD L + H Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC----LQVLEGHTD 388 Query: 306 EVWSVSWNLTGTILSSAGDDGKVRLWK 332 E++S ++N G I+ + D R+W+ Sbjct: 389 EIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 62/327 (18%), Positives = 113/327 (34%), Gaps = 42/327 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H + +V + G T S D+ K++ DT++ E ++ H + + AI + +P Sbjct: 90 AHILPLTNVALNKSGSCFITGSYDRTCKLW----DTASGEELNTLEGHRNVVYAIAFNNP 145 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 YG IA+ S+DKT KLW + T + + F P +A Sbjct: 146 -YGDKIATGSFDKTCKLWSVETG---------KCYHTFRGHTAEIVCLSFNPQST--LVA 193 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D +L+D ++ + H LS+ S +++ Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTL-------------RGHSAEIISLSF---NTSGDRIITG 237 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + + ++ G+ L GH + I S S+ LI TG D +++ T Sbjct: 238 SFDHTVVVWDADTGRK--VNILIGHCAEISSASFNWD----CSLILTGSMDKTCKLWDAT 291 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 + A +D + +++ + H GE Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC----IAKLEGHEGE 347 Query: 307 VWSVSWNLTGTILSSAGDDGKVRLWKA 333 + +S+N G L + D R+W A Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDA 374 Score = 104 bits (259), Expect = 5e-23, Method: Composition-based stats. Identities = 59/333 (17%), Positives = 115/333 (34%), Gaps = 48/333 (14%) Query: 24 VATCSSDQHIKVFKL-------DKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASAS 76 + T S + +K+ + L +AH + + A + G + S Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNV--ALNKSGSCFITGS 111 Query: 77 YDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRL 136 YD+T KLW+ +E L TL + +Y++ F G K+A D +L Sbjct: 112 YDRTCKLWDTASGEE---------LNTLEGHRNVVYAIAFN-NPYGDKIATGSFDKTCKL 161 Query: 137 YDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQR 196 + ++ H CLS+ P +A +++ Sbjct: 162 WSVETGKCYHTF-------------RGHTAEIVCLSFNP---QSTLVATGSMDTTAKLWD 205 Query: 197 GKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 256 ++G+ L GH + I S+S+ S R I TG D + ++ Sbjct: 206 IQNGE--EVYTLRGHSAEIISLSFNTSGDR----IITGSFDHTVVVWDADTGRKVNILIG 259 Query: 257 SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTG 316 + + D + G D + ++ H+ E+ ++ TG Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKC----VATLTGHDDEILDSCFDYTG 315 Query: 317 TILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 349 ++++A DG R++ A KC++ + + Sbjct: 316 KLIATASADGTARIFSAATR---KCIAKLEGHE 345 Score = 103 bits (257), Expect = 8e-23, Method: Composition-based stats. Identities = 29/133 (21%), Positives = 52/133 (39%), Gaps = 17/133 (12%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GHDD + D +D+ G+ +AT S+D ++F + H+ I I + Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATR----KCIAKLEGHEGEISKISFNP 355 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G + + S DKT ++W+ Q L L ++S F + G + Sbjct: 356 --QGNHLLTGSSDKTARIWDAQTGQ---------CLQVLEGHTDEIFSCAF--NYKGNIV 402 Query: 126 ACLGNDGILRLYD 138 D R++ Sbjct: 403 ITGSKDNTCRIWR 415 >3DM0-A nrPDB Length = 694 Score = 147 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 50/237 (21%), Positives = 88/237 (37%), Gaps = 17/237 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V V + R + + S D+ IK++ + + +S+ H + + ++ Sbjct: 470 GHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGEC-KYTISEGGEGHRDWVSCVRFSPN 528 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 I SAS+DKTVK+W + C R TL G + +V +P G A Sbjct: 529 TLQPTIVSASWDKTVKVW----NLSNCKLR-----STLAGHTGYVSTVAVSPD--GSLCA 577 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 G DG++ L+D E L S S + L P + + E ++ Sbjct: 578 SGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPNRYWL-CAATEHGIKIWDLESKSIV 636 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 + + + A S++W+ + +G DG IR++ Sbjct: 637 EDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSAD----GSTLFSGYTDGVIRVW 689 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 57/341 (16%), Positives = 123/341 (36%), Gaps = 47/341 (13%) Query: 7 GHDDLVHDVVYDFYG-RHVATCSSDQHIKVFKLDKDTSNWELS-DSWRAHDSSIVAIDWA 64 H D+V + + + S D+ I ++KL KD + ++ H + + + Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLS 439 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 S G+ S S+D ++LW+ + SV F+ + + Sbjct: 440 SD--GQFALSGSWDGELRLWDLAAGVSTRR---------FVGHTKDVLSVAFSLDNR--Q 486 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 + D ++L++ L +S H C+ + P+ P ++ Sbjct: 487 IVSASRDRTIKLWNTLGECKYT----------ISEGGEGHRDWVSCVRFSPNTLQPTIVS 536 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 S + ++ + + L GH + +++ +P L A+G KDG + ++ Sbjct: 537 ASWDKTVKVWNLSN---CKLRSTLAGHTGYVSTVAVSPD----GSLCASGGKDGVVLLWD 589 Query: 245 ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT---EEKAELQSNLQVELLSEHD 301 + E + E + + + S + E + +L+V+L +E + Sbjct: 590 LAEGKKLYSLE-ANSVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAE 648 Query: 302 DHNGE-----------VWSVSWNLTGTILSSAGDDGKVRLW 331 + S++W+ G+ L S DG +R+W Sbjct: 649 KADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 64.3 bits (154), Expect = 8e-11, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 72/230 (31%), Gaps = 19/230 (8%) Query: 103 TLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPA 162 T+ + ++ P + D + L+ + Sbjct: 377 TMRAHTDMVTAIA-TPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVED 435 Query: 163 NHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAP 222 L SD L+ S + ++ + GH + S++++ Sbjct: 436 VVLSSD----------GQFALSGSWDGELRLWDLAAGVSTR---RFVGHTKDVLSVAFSL 482 Query: 223 SIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT 282 + I + +D I+++ + SE + + Q S + Sbjct: 483 DN----RQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSAS 538 Query: 283 EEKAELQSNLQ-VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 +K NL +L S H G V +V+ + G++ +S G DG V LW Sbjct: 539 WDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLW 588 Score = 50.0 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 21/145 (14%), Positives = 51/145 (35%), Gaps = 20/145 (13%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V V G A+ D + ++ L + + L + H A+ ++ Sbjct: 558 AGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIH-----ALCFSP 612 Query: 66 PEYGRIIASASYDKTVKLWEEDP----DQEECSGRRWNKLCTLNDSKGS------LYSVK 115 Y A+ + +K+W+ + + + + + + + S+ Sbjct: 613 NRYWLCAAT---EHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLN 669 Query: 116 FAPAHLGLKLACLGNDGILRLYDAL 140 ++ G L DG++R++ Sbjct: 670 WSAD--GSTLFSGYTDGVIRVWGIG 692 >6HQA-B nrPDB Length = 722 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 52/295 (17%), Positives = 110/295 (37%), Gaps = 39/295 (13%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V+ V + R++ +CS D+ ++++ LD + S++ H SS+ + ++ Sbjct: 451 GHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT----YTCLVSYKGHSSSVWDVKFSP- 505 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G A+AS+D+T +LW D L + V+F P L Sbjct: 506 -MGHYFATASHDQTARLWSCD---------HIYPLRIFAGHLNDVDCVEFHPNST--YLF 553 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +D R++D +R + H + CL+ P LA + Sbjct: 554 TGSSDKTARMWDIARGECVRVF-------------MGHSGAINCLAVSP---DGRWLASA 597 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + + G+ + A +S I S++++ R ++ + D +R++ + Sbjct: 598 GEDSVVCLWDISTGR-RIKAMRGHGRSSIYSLAFS----REGTVLVSTGADNSVRVWDVK 652 Query: 247 EKL-SPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 300 + SP A E + + + + + T + + + + + H Sbjct: 653 KNTNSPSAQPEPINDVTAQGIQKKTEDLRRRKEIVATNDHMSVYFTKKTPVYTVH 707 Score = 115 bits (286), Expect = 4e-26, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 107/304 (35%), Gaps = 53/304 (17%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDK-----------------DTSNWELSDSW 51 ++ + + ++ VA+ D IK++ +D D + S Sbjct: 390 NNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRL 449 Query: 52 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 111 H ++ +D++ + S S DKTV+LW D + L + S+ Sbjct: 450 VGHSGAVYGVDFSPDNR--YLISCSEDKTVRLWSLDT---------YTCLVSYKGHSSSV 498 Query: 112 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 171 + VKF+P +G A +D RL+ LR + A HL C+ Sbjct: 499 WDVKFSP--MGHYFATASHDQTARLWSCDHIYPLRIF-------------AGHLNDVDCV 543 Query: 172 SWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 + P+ S S+ + A ++ + GH I ++ +P GRW + Sbjct: 544 EFHPN--STYLFTGSSDKTARMWDI---ARGECVRVFMGHSGAINCLAVSPD-GRW---L 594 Query: 232 ATGCKDGRIRIFKITEKLSPLASEESL-TNSNMFDNSADVDMDAQGRSDSNTEEKAELQS 290 A+ +D + ++ I+ A ++ S + + +D++ ++ Sbjct: 595 ASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKN 654 Query: 291 NLQV 294 Sbjct: 655 TNSP 658 Score = 97.8 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 58/320 (18%), Positives = 116/320 (36%), Gaps = 48/320 (15%) Query: 47 LSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDP------------DQEECS 94 ++ ++ + + + + ++AS D +KLW D +Q+ Sbjct: 382 CMYTFHNTNNDLTCLKF--NDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNND 439 Query: 95 GRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEM 154 G L G++Y V F+P + L D +RL+ L ++T Sbjct: 440 GVAVKGSRRLVGHSGAVYGVDFSPDNR--YLISCSEDKTVRLWS------LDTYTCL--- 488 Query: 155 KVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKS 213 + H S + + + P A ++ +Q ++ L + A GH + Sbjct: 489 ----VSYKGHSSSVWDVKFSPM---GHYFATASHDQTARLWSCDHIYPLRIFA---GHLN 538 Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMD 273 + + + P+ + TG D R++ I N S D Sbjct: 539 DVDCVEFHPN----STYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWL 594 Query: 274 AQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW-- 331 A DS + + +++ + H ++S++++ GT+L S G D VR+W Sbjct: 595 ASAGEDSVVCLWD-ISTGRRIKAMRGHG--RSSIYSLAFSREGTVLVSTGADNSVRVWDV 651 Query: 332 KATY---SNEFKCMSVITAQ 348 K S + + ++ +TAQ Sbjct: 652 KKNTNSPSAQPEPINDVTAQ 671 Score = 93.9 bits (231), Expect = 9e-20, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 60/142 (42%), Gaps = 18/142 (12%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH + V V + ++ T SSD+ +++ + + E + H +I + Sbjct: 532 IFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIAR----GECVRVFMGHSGAINCLAV 587 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDS-KGSLYSVKFAPAHLG 122 + GR +ASA D V LW+ ++ + + S+YS+ F+ G Sbjct: 588 SPD--GRWLASAGEDSVVCLWDISTG---------RRIKAMRGHGRSSIYSLAFS--REG 634 Query: 123 LKLACLGNDGILRLYDALEPSD 144 L G D +R++D + ++ Sbjct: 635 TVLVSTGADNSVRVWDVKKNTN 656 >1VYH-C nrPDB Length = 410 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 57/297 (19%), Positives = 100/297 (33%), Gaps = 49/297 (16%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D V D+ +D G+ +A+CS+D IK++ +E + HD ++ ++ Sbjct: 148 GHTDSVQDISFDHSGKLLASCSADMTIKLWDF----QGFECIRTMHGHDHNVSSVSIMPN 203 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G I SAS DKT+K+WE + T + + V+ P G +A Sbjct: 204 --GDHIVSASRDKTIKMWEVQTG---------YCVKTFTGHREWVRMVR--PNQDGTLIA 250 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 ND +R++ + + +E++ H C+SW P + Sbjct: 251 SCSNDQTVRVW------VVATKECKAELR-------EHRHVVECISWAPESSYSSISEAT 297 Query: 187 ALEQAIIYQRG--------------KDGKL-HVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 E + G D L GH + +R + + S G++ I Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH-SGGKF---I 353 Query: 232 ATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 + D +R++ K D G D + Sbjct: 354 LSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 53/343 (15%), Positives = 119/343 (34%), Gaps = 55/343 (16%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V V++ + + S D IKV+ + + + + H S+ I + Sbjct: 105 SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLKGHTDSVQDISFDH 160 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G+++AS S D T+KLW+ + + + T++ ++ SV P G + Sbjct: 161 S--GKLLASCSADMTIKLWDF---------QGFECIRTMHGHDHNVSSVSIMPN--GDHI 207 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 D +++++ ++++T H + + P++ + Sbjct: 208 VSASRDKTIKMWEVQTGYCVKTFT-------------GHREWVRMVR--PNQDGTLIASC 252 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPS----------------IGRWYQ 229 S + ++ A+L H+ ++ ISWAP G+ Sbjct: 253 SNDQTVRVW---VVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGP 309 Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 + +G +D I+++ ++ + + + D Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369 Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 L + H V S+ ++ T + + D V++W+ Sbjct: 370 KRCMKTL----NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 95.9 bits (236), Expect = 2e-20, Method: Composition-based stats. Identities = 53/315 (16%), Positives = 110/315 (34%), Gaps = 54/315 (17%) Query: 51 WRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGS 110 H S + + + ++ SAS D T+K+W+ + E TL S Sbjct: 104 LSGHRSPVTRVIFHP--VFSVMVSASEDATIKVWDYETGDFE---------RTLKGHTDS 152 Query: 111 LYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFC 170 + + F H G LA D ++L+D +R+ H + Sbjct: 153 VQDISF--DHSGKLLASCSADMTIKLWDFQGFECIRTM-------------HGHDHNVSS 197 Query: 171 LSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQL 230 +S P + + + ++ ++ I + G + GH+ +R + P+ + L Sbjct: 198 VSIMP---NGDHIVSASRDKTIKMWEVQTG--YCVKTFTGHREWVRMVR--PN--QDGTL 248 Query: 231 IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN--------- 281 IA+ D +R++ + K E + + + + + Sbjct: 249 IASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPG 308 Query: 282 ------TEEKAELQSNLQVELLS-EHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 + +K ++ + H+ V V ++ G + S DD +R+W Sbjct: 309 PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW--D 366 Query: 335 YSNEFKCMSVITAQQ 349 Y N+ +CM + A + Sbjct: 367 YKNK-RCMKTLNAHE 380 Score = 35.8 bits (80), Expect = 0.027, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 17/33 (51%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKL 38 + H+ V + + +V T S DQ +KV++ Sbjct: 377 NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWEC 409 >6G51-g nrPDB Length = 317 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 56/335 (16%), Positives = 125/335 (37%), Gaps = 39/335 (11%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWEL-SDSWRAHDSSIVAIDWA 64 GH+ V + + + + S D+ I ++KL +D +N+ + + R H + + + Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 S G+ S S+D T++LW+ +G + + SV F+ + + Sbjct: 73 SD--GQFALSGSWDGTLRLWDL------TTGTTTRRFV---GHTKDVLSVAFSSDNR--Q 119 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 + D ++L++ L + ++ +H + C+ + P+ +P ++ Sbjct: 120 IVSGSRDKTIKLWNTLG------------VCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 + ++ + GH + +++ +P L A+G KDG+ ++ Sbjct: 168 CGWDKLVKVWNLAN---CKLKTNHIGHTGYLNTVTVSPD----GSLCASGGKDGQAMLWD 220 Query: 245 ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT----EEKAELQSNLQVELLSEH 300 + E + N S + S E K + Q + + Sbjct: 221 LNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSS 279 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATY 335 + S++W+ G L + D VR+W+ T Sbjct: 280 KAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314 Score = 59.6 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 60/172 (34%), Gaps = 25/172 (14%) Query: 5 DSGHDDLVHDVVYDFYGRH--VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 62 D H + V V + + + +C D+ +KV+ L N +L + H + + Sbjct: 144 DESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA----NCKLKTNHIGHTGYLNTVT 199 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 + G + AS D LW+ + + + + + ++ F+P Sbjct: 200 VSPD--GSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI----------INALCFSPNRYW 247 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 L A + ++++D + L E V+S L+W Sbjct: 248 LCAATGPS---IKIWDL--EGKIIVDELKQE--VISTSSKAEPPQCTSLAWS 292 >5GAN-H nrPDB Length = 465 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 92/272 (33%), Gaps = 56/272 (20%) Query: 7 GHDDLVHDVVYDFY-GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 H + + + + +C+ D IK F+ + L H+ I + + Sbjct: 216 SHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHP 275 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQE----------------------ECSG-------- 95 G+ I SAS+D T +LW+ QE CSG Sbjct: 276 S--GKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSML 333 Query: 96 ---RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTS 152 R +K+ TL +Y+V ++P G ++A G DGI+ ++D + + + + + Sbjct: 334 WDIRSGSKVMTLAGHSKPIYTVAWSPN--GYQVATGGGDGIINVWDIRKRDEGQLNQILA 391 Query: 153 EMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHK 212 H + + + ++ +Y L GH Sbjct: 392 -----------HRNIVTQVRFSKEDGGKKLVSCGYDNLINVY---SSDTWLKMGSLAGHT 437 Query: 213 SLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 I S+ + + + +G D I+++ Sbjct: 438 DKIISLDISNN----SHFLVSGGWDRSIKLWN 465 Score = 87.0 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 113/330 (34%), Gaps = 47/330 (14%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 + V VAT S ++V L+ +H I AIDW Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQP---LTQKLDSHVGKIGAIDWHPDSN 231 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 ++I S + D +K ++ ++ L L + + VK+ P+ G + Sbjct: 232 NQMI-SCAEDGLIKNFQYSNEEGGLRL-----LGDLVGHERRISDVKYHPS--GKFIGSA 283 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSAL 188 +D RL+DA +L + H + F LS+ + + + Sbjct: 284 SHDMTWRLWDASTHQEL-------------LLQEGHDKGVFSLSF---QCDGSLVCSGGM 327 Query: 189 EQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEK 248 + + + G + L GH I +++W+P+ +ATG DG I ++ I Sbjct: 328 DSLSMLWDIRSGSKVM--TLAGHSKPIYTVAWSPN----GYQVATGGGDGIINVWDI--- 378 Query: 249 LSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL----QVELLSEH---D 301 + + + + V + D + + NL + + Sbjct: 379 ----RKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLA 434 Query: 302 DHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 H ++ S+ + L S G D ++LW Sbjct: 435 GHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 78.5 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 27/133 (20%), Positives = 56/133 (42%), Gaps = 13/133 (9%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH ++ V + G VAT D I V+ + K +L+ AH + + + ++ Sbjct: 346 AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKR-DEGQLNQIL-AHRNIVTQVRFSK 403 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + G+ + S YD + ++ D W K+ +L + S+ + + L Sbjct: 404 EDGGKKLVSCGYDNLINVYSSDT---------WLKMGSLAGHTDKIISLDIS--NNSHFL 452 Query: 126 ACLGNDGILRLYD 138 G D ++L++ Sbjct: 453 VSGGWDRSIKLWN 465 Score = 65.8 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 45/305 (14%), Positives = 98/305 (32%), Gaps = 38/305 (12%) Query: 44 NWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCT 103 N EL+ S I A+ ++ + ++A+ S+ +++ Q Sbjct: 164 NLELAGSQLVSTKPISAVSLSTDDM--VVATGSWAGDLQVLNSQTLQPLTQ--------K 213 Query: 104 LNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPAN 163 L+ G + ++ + P ++ DG+++ + ++ L Sbjct: 214 LDSHVGKIGAIDWHPDSNN-QMISCAEDGLIKNF---------QYSNEEGGLRLLGDLVG 263 Query: 164 HLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKL-PGHKSLIRSISWAP 222 H + + + PS + + + + R D H L GH + S+S+ Sbjct: 264 HERRISDVKYHPSGK-----FIGSASHDMTW-RLWDASTHQELLLQEGHDKGVFSLSFQC 317 Query: 223 SIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT 282 L+ +G D ++ I + S + A G D Sbjct: 318 D----GSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGII 373 Query: 283 EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT--GTILSSAGDDGKVRLWKATYSNEFK 340 + + L++ H V V ++ G L S G D + ++ S+ + Sbjct: 374 NVWDIRKRDEGQ--LNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYS---SDTWL 428 Query: 341 CMSVI 345 M + Sbjct: 429 KMGSL 433 >6MZM-G nrPDB Length = 800 Score = 133 bits (335), Expect = 8e-32, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 102/283 (36%), Gaps = 41/283 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V+ + ++ + S D ++++ L + ++ H+ + ++ Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL----QTFTCLVGYKGHNYPVWDTQFSP- 595 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 YG S +D+ +LW D + L + +F P +A Sbjct: 596 -YGYYFVSGGHDRVARLWATD---------HYQPLRIFAGHLADVNCTRFHPNSN--YVA 643 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D +RL+D L + +R +T H L++ P + LA Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFT-------------GHKGPIHSLTFSP---NGRFLATG 687 Query: 187 ALEQAIIYQRGKD-GKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 A + ++ D G + +L GH + S+ ++ R +++A+G D +R++ Sbjct: 688 ATDGRVLL---WDIGHGLMVGELKGHTDTVCSLRFS----RDGEILASGSMDNTVRLWDA 740 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 + L +++ T + + + G + + L Sbjct: 741 IKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHL 783 Score = 104 bits (259), Expect = 5e-23, Method: Composition-based stats. Identities = 45/256 (17%), Positives = 91/256 (35%), Gaps = 39/256 (15%) Query: 51 WRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGS 110 H + ++ + S+S D TV+LW + L Sbjct: 539 LYGHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQT---------FTCLVGYKGHNYP 587 Query: 111 LYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFC 170 ++ +F+P G G+D + RL+ LR + A HL C Sbjct: 588 VWDTQFSP--YGYYFVSGGHDRVARLWATDHYQPLRIF-------------AGHLADVNC 632 Query: 171 LSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQ 229 + P + +A + ++ + ++ + + GHK I S++++P+ + Sbjct: 633 TRFHP---NSNYVATGSADRTVRLWDVLNGNCVRI---FTGHKGPIHSLTFSPN----GR 682 Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 +ATG DGR+ ++ I L + S D ++ A G D+ ++ Sbjct: 683 FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742 Query: 290 --SNLQVELLSEHDDH 303 +L+ + + H Sbjct: 743 AFEDLETDDFTTATGH 758 Score = 98.5 bits (243), Expect = 3e-21, Method: Composition-based stats. Identities = 29/138 (21%), Positives = 59/138 (42%), Gaps = 17/138 (12%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH V+ + +VAT S+D+ ++++ + N + H I ++ + Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL----NGNCVRIFTGHKGPIHSLTF 677 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 + GR +A+ + D V LW+ + L ++ S++F+ G Sbjct: 678 SPN--GRFLATGATDGRVLLWDI---------GHGLMVGELKGHTDTVCSLRFS--RDGE 724 Query: 124 KLACLGNDGILRLYDALE 141 LA D +RL+DA++ Sbjct: 725 ILASGSMDNTVRLWDAIK 742 Score = 86.2 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 74/233 (31%), Gaps = 30/233 (12%) Query: 102 CTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP 161 L G +Y F+P L DG +RL W+L + ++ Sbjct: 537 KILYGHSGPVYGASFSPDRN--YLLSSSEDGTVRL-----------WSLQTFTCLVGYKG 583 Query: 162 ANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISW 220 N+ D S ++ ++ L + A GH + + + Sbjct: 584 HNYPVWDTQFS-----PYGYYFVSGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRF 635 Query: 221 APSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 P+ +ATG D +R++ + + S + A G +D Sbjct: 636 HPN----SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691 Query: 281 NTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 ++ E H V S+ ++ G IL+S D VRLW A Sbjct: 692 RVLLWDIGHG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 81.2 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 44/101 (43%), Gaps = 6/101 (5%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH +H + + GR +AT ++D + ++ + + + + H ++ ++ + Sbjct: 664 IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI----GHGLMVGELKGHTDTVCSLRF 719 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTL 104 G I+AS S D TV+LW+ E+ + Sbjct: 720 --SRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGH 758 >6F3T-A nrPDB Length = 608 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 102/283 (36%), Gaps = 41/283 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V+ + ++ + S D ++++ L + ++ H+ + ++ Sbjct: 349 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL----QTFTCLVGYKGHNYPVWDTQFSP- 403 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 YG S +D+ +LW D + L + +F P +A Sbjct: 404 -YGYYFVSGGHDRVARLWATD---------HYQPLRIFAGHLADVNCTRFHPNSN--YVA 451 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D +RL+D L + +R +T H L++ P + LA Sbjct: 452 TGSADRTVRLWDVLNGNCVRIFT-------------GHKGPIHSLTFSP---NGRFLATG 495 Query: 187 ALEQAIIYQRGKD-GKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 A + ++ D G + +L GH + S+ ++ R +++A+G D +R++ Sbjct: 496 ATDGRVLL---WDIGHGLMVGELKGHTDTVCSLRFS----RDGEILASGSMDNTVRLWDA 548 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 + L +++ T + + + G + + L Sbjct: 549 IKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHL 591 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 49/314 (15%), Positives = 101/314 (32%), Gaps = 66/314 (21%) Query: 20 YGRHVATCSSDQHIKVFKLDK---------------------------DTSNWELSDSWR 52 +A +D ++V+ + D Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 348 Query: 53 AHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 112 H + ++ + S+S D TV+LW + L ++ Sbjct: 349 GHSGPVYGASFSPDR--NYLLSSSEDGTVRLWSLQT---------FTCLVGYKGHNYPVW 397 Query: 113 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLS 172 +F+P G G+D + RL+ LR + A HL C Sbjct: 398 DTQFSP--YGYYFVSGGHDRVARLWATDHYQPLRIF-------------AGHLADVNCTR 442 Query: 173 WCPSRFSPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 + P + +A + ++ + ++ + + GHK I S++++P+ + + Sbjct: 443 FHP---NSNYVATGSADRTVRLWDVLNGNCVRI---FTGHKGPIHSLTFSPN----GRFL 492 Query: 232 ATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ-- 289 ATG DGR+ ++ I L + S D ++ A G D+ ++ Sbjct: 493 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAF 552 Query: 290 SNLQVELLSEHDDH 303 +L+ + + H Sbjct: 553 EDLETDDFTTATGH 566 Score = 98.5 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 29/138 (21%), Positives = 59/138 (42%), Gaps = 17/138 (12%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH V+ + +VAT S+D+ ++++ + N + H I ++ + Sbjct: 430 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL----NGNCVRIFTGHKGPIHSLTF 485 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 + GR +A+ + D V LW+ + L ++ S++F+ G Sbjct: 486 SPN--GRFLATGATDGRVLLWDI---------GHGLMVGELKGHTDTVCSLRFS--RDGE 532 Query: 124 KLACLGNDGILRLYDALE 141 LA D +RL+DA++ Sbjct: 533 ILASGSMDNTVRLWDAIK 550 Score = 91.6 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 89/288 (30%), Gaps = 52/288 (18%) Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGR----------------------RWNKLCTLND 106 +IA D TV++W P + + ++L L Sbjct: 290 SSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYG 349 Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 G +Y F+P L DG +RL W+L + ++ N+ Sbjct: 350 HSGPVYGASFSPDRN--YLLSSSEDGTVRL-----------WSLQTFTCLVGYKGHNYPV 396 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 225 D S ++ ++ L + A GH + + + P+ Sbjct: 397 WDTQFS-----PYGYYFVSGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRFHPN-- 446 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 +ATG D +R++ + + S + A G +D Sbjct: 447 --SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 504 Query: 286 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 ++ E H V S+ ++ G IL+S D VRLW A Sbjct: 505 DIGHG----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 548 Score = 80.8 bits (197), Expect = 7e-16, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 44/101 (43%), Gaps = 6/101 (5%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH +H + + GR +AT ++D + ++ + + + + H ++ ++ + Sbjct: 472 IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI----GHGLMVGELKGHTDTVCSLRF 527 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTL 104 G I+AS S D TV+LW+ E+ + Sbjct: 528 --SRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGH 566 Score = 44.2 bits (102), Expect = 7e-05, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 43/109 (39%), Gaps = 15/109 (13%) Query: 223 SIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT 282 + LIA G D +R++ +T K + ++D+ + + D Sbjct: 285 DVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQ-----------ASDLSLIDKESDDVLE 333 Query: 283 EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 E ++ L H+G V+ S++ L S+ +DG VRLW Sbjct: 334 RIMDEKTASELKILY----GHSGPVYGASFSPDRNYLLSSSEDGTVRLW 378 >5MZH-A nrPDB Length = 452 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 56/351 (15%), Positives = 110/351 (31%), Gaps = 48/351 (13%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H + + ++ G T S D+ KV+ + + H + + AI + +P Sbjct: 92 AHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF----TLEGHKNVVYAIAFNNP 147 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 YG I + S+DKT KLW+ Q TL + + + F P +A Sbjct: 148 -YGDKIVTGSFDKTCKLWDAYTGQL---------YYTLKGHQTEIVCLSFNPQST--IIA 195 Query: 127 CLGNDGILRLYDALEPSDLRS------------WTLTSEMKVLSIPPANHLQSDFCLSWC 174 D +L+D + + + ++ V + D C Sbjct: 196 TGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQC 255 Query: 175 PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKL------------PGHKSLIRSISWAP 222 S + VS+ + G + ++L GH + +++ Sbjct: 256 VHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDA 315 Query: 223 SIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT 282 + + + + DG R++ + + + SD Sbjct: 316 AGTK----MVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTC 371 Query: 283 EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 L + H E++S ++N G + + D R+WKA Sbjct: 372 RLWDCDTGEC----LQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 117 bits (293), Expect = 5e-27, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 95/287 (33%), Gaps = 39/287 (13%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH + + ++ +AT S D K++ ++ + + H + IV++ + Sbjct: 177 GHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVET----GQERATLAGHRAEIVSLGF--N 230 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G +I + S+D +LW+ Q + L+ +G + S +F + G + Sbjct: 231 TGGDLIVTGSFDHDSRLWDVRTGQ---------CVHVLSGHRGEVSSTQF--NYAGTLVV 279 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D RL+D L H +++ + + ++ S Sbjct: 280 SGSIDCTSRLWDVRSGRCLSV-------------KQGHTDEVLDVAFDAAG--TKMVSAS 324 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 A A +Y L GH+ I +++ P R + T D R++ Sbjct: 325 ADGSARLYHTLTG---VCQHTLVGHEGEISKVAFNPQGTR----LITASSDKTCRLWDCD 377 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ 293 E + + D G D+ L ++ Q Sbjct: 378 TGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTASSQ 424 Score = 97.8 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 44/239 (18%), Positives = 76/239 (31%), Gaps = 39/239 (16%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH + + ++ G + T S D +++ + + H + + + Sbjct: 218 AGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRT----GQCVHVLSGHRGEVSSTQFNY 273 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G ++ S S D T +LW+ R L + V F G K+ Sbjct: 274 --AGTLVVSGSIDCTSRLWDV---------RSGRCLSVKQGHTDEVLDVAF--DAAGTKM 320 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 DG RLY L + H +++ P + Sbjct: 321 VSASADGSARLYHTLTGVCQHTLV-------------GHEGEISKVAFNPQG--TRLITA 365 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 S+ + ++ L V L GH I S ++ I TG KD RI+K Sbjct: 366 SSDKTCRLWDCDTGECLQV---LEGHTDEIFSCAFN----YEGDFIITGSKDNTCRIWK 417 Score = 97.4 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 32/137 (23%), Positives = 53/137 (38%), Gaps = 17/137 (12%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 GH D V DV +D G + + S+D +++ + H+ I + + Sbjct: 300 VKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLT----GVCQHTLVGHEGEISKVAF 355 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 G + +AS DKT +LW+ D EC L L ++S F + G Sbjct: 356 NP--QGTRLITASSDKTCRLWDCDT--GEC-------LQVLEGHTDEIFSCAF--NYEGD 402 Query: 124 KLACLGNDGILRLYDAL 140 + D R++ AL Sbjct: 403 FIITGSKDNTCRIWKAL 419 >4V6W-Ag nrPDB Length = 318 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 52/337 (15%), Positives = 115/337 (34%), Gaps = 40/337 (11%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKL--DKDTSNWELSDSWRAHDSSIVAIDW 63 GH+ V + + + + S D+ + V+KL D+DT+ H I + Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVL 72 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 +S G S S+D+T++LW+ + SV F+ + Sbjct: 73 SSD--GNYALSGSWDQTLRLWDL---------AAGKTTRRFEGHTKDVLSVAFSADNR-- 119 Query: 124 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 ++ D ++L++ L +I H C+ + P+ +P + Sbjct: 120 QIVSGSRDKTIKLWNTLAE------------CKFTIQEDGHTDWVSCVRFSPNHSNPIIV 167 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 + ++ + GH + +++ +P L +G KD + ++ Sbjct: 168 SCGWDRTVKVWNLAN---CKLKNNHHGHNGYLNTVTVSPD----GSLCTSGGKDSKALLW 220 Query: 244 KITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT-EEKAELQSNLQVELLSEHDD 302 + + + E N S + S + A ++ ++ Sbjct: 221 DLNDGKNLYTLE-HNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPT 279 Query: 303 HNG---EVWSVSWNLTGTILSSAGDDGKVRLWKATYS 336 + S++W+ G L + D +R+W+ + S Sbjct: 280 SKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVS 316 >4V8M-A7 nrPDB Length = 318 Score = 123 bits (309), Expect = 7e-29, Method: Composition-based stats. Identities = 62/337 (18%), Positives = 116/337 (34%), Gaps = 45/337 (13%) Query: 6 SGHDDLVHDVV---YDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSW-----RAHDSS 57 +GH V + V + S D+ + + + D + E S H + Sbjct: 10 TGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAF 69 Query: 58 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA 117 + + A G SAS+D +++LW Q + + SV F+ Sbjct: 70 VSDV--ALSNNGNFAVSASWDHSLRLWNLQNGQCQYK---------FLGHTKDVLSVAFS 118 Query: 118 PAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSR 177 P + ++ G D LR+++ + ++ H C+ + PS Sbjct: 119 PDNR--QIVSGGRDNALRVWNVKGE------------CMHTLSRGAHTDWVSCVRFSPS- 163 Query: 178 FSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKD 237 + + + G+L L GH + + S++ +P L A+ KD Sbjct: 164 LDAPVIVSGGWDNLVKVWDLATGRL--VTDLKGHTNYVTSVTVSPD----GSLCASSDKD 217 Query: 238 GRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELL 297 G R++ +T+ L+ + N S + ++ VEL Sbjct: 218 GVARLWDLTKG-EALSEMAAGAPINQICFSPNRYWMCAATEKGI-RIFDLENKDIIVELA 275 Query: 298 SEHDDHNG---EVWSVSWNLTGTILSSAGDDGKVRLW 331 EH E S++W+ G+ L S D +R+W Sbjct: 276 PEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 39/243 (16%), Positives = 80/243 (32%), Gaps = 31/243 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V V + R + + D ++V+ + + LS AH + + ++ Sbjct: 107 GHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGEC-MHTLSRG--AHTDWVSCVRFSPS 163 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 +I S +D VK+W+ + + L + SV +P G A Sbjct: 164 LDAPVIVSGGWDNLVKVWDLATGRL---------VTDLKGHTNYVTSVTVSPD--GSLCA 212 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 DG+ RL+D + L + + + P + + + Sbjct: 213 SSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMC------AATEKGIRIFDLE 266 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + + G + + SI+W+ + +G D IR++ ++ Sbjct: 267 NKDIIVELAPEHQGSKKIVPECV-------SIAWSAD----GSTLYSGYTDNVIRVWGVS 315 Query: 247 EKL 249 E Sbjct: 316 ENA 318 >6HHQ-h nrPDB Length = 319 Score = 120 bits (300), Expect = 8e-28, Method: Composition-based stats. Identities = 54/332 (16%), Positives = 116/332 (34%), Gaps = 38/332 (11%) Query: 7 GHDDLVHDVVYDFYG-RHVATCSSDQHIKVFKLDKDTSNWEL-SDSWRAHDSSIVAIDWA 64 GH+ V + + + S D+ + +KL D + + S++ H + Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLT 74 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + G SAS+DKT++LW+ +G + + K + SV Sbjct: 75 AD--GAYALSASWDKTLRLWD------VATGETYQRFV---GHKSDVMSVDI--DKKASM 121 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPS-RFSPEKL 183 + D +++ WT+ + + H + P+ + + + Sbjct: 122 IISGSRDKTIKV-----------WTIKGQCLATLL---GHNDWVSQVRVVPNEKADDDSV 167 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 + + + + + + A GH S I +++ +P LIA+ KDG I ++ Sbjct: 168 TIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPD----GTLIASAGKDGEIMLW 223 Query: 244 KITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN---TEEKAELQSNLQVELLSEH 300 + K + + S + A + + + L +L+ E Sbjct: 224 NLAAKKAMYTL-SAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYS 282 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 S++W+ G L + D +R+W+ Sbjct: 283 KAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314 Score = 93.2 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 102/293 (34%), Gaps = 44/293 (15%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH +V D G + + S D+ ++++ + E + H S ++++D Sbjct: 63 GHSHIVQDCTLTADGAYALSASWDKTLRLWDVAT----GETYQRFVGHKSDVMSVDI--D 116 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + +I S S DKT+K+W + +C L TL + V+ P Sbjct: 117 KKASMIISGSRDKTIKVW---TIKGQC-------LATLLGHNDWVSQVRVVPNEK----- 161 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +D + + A +++W L H + L+ P + Sbjct: 162 --ADDDSVTIISAGNDKMVKAWNLNQFQIEADFI--GHNSNINTLTASPDG--TLIASAG 215 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + +++ L + + S++++P+ R++ AT I++F + Sbjct: 216 KDGEIMLWNL---AAKKAMYTLSA-QDEVFSLAFSPN--RYWLAAATATG---IKVFSLD 266 Query: 247 E--KLSPLASEESLTNSN------MFDNSADVDMDAQGRSDSNTEEKAELQSN 291 + L E + + SAD G +D+ + +N Sbjct: 267 PQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 Score = 62.0 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 89/240 (37%), Gaps = 19/240 (7%) Query: 93 CSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTS 152 S TL G + S+ + L L D L SW LT Sbjct: 2 ASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLL-SASRDKT-----------LISWKLTG 49 Query: 153 EMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHK 212 + + +P + + C ++ ++ + G+ + + GHK Sbjct: 50 DDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETY--QRFVGHK 107 Query: 213 SLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDM 272 S + S+ I + +I +G +D I+++ I + + S + + Sbjct: 108 SDVMSV----DIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKAD 163 Query: 273 DAQGRSDSNTEEKAELQSNL-QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 D S +K NL Q ++ ++ HN + +++ + GT+++SAG DG++ LW Sbjct: 164 DDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLW 223 >3JAP-g nrPDB Length = 326 Score = 120 bits (300), Expect = 9e-28, Method: Composition-based stats. Identities = 50/338 (14%), Positives = 109/338 (32%), Gaps = 44/338 (13%) Query: 7 GHDDLVHDVVYDFYG-RHVATCSSDQHIKVFKLDKDTSNWEL-SDSWRAHDSSIVAIDWA 64 GH+ V + + + S D+ + ++L ++ + + S++ H + + + Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVS 75 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + G SAS+DKT++LW E G + SV K Sbjct: 76 AD--GNYAVSASWDKTLRLWNLATGNSEAR---------FVGHTGDVLSVAIDANS--SK 122 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK-- 182 + D +R+++ + + H + P + Sbjct: 123 IISASRDKTIRVWNTVGD--------------CAYVLLGHTDWVTKVRVAPKNLEDGEVD 168 Query: 183 -----LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKD 237 + +++ + + + A GH + I + +P L A+ KD Sbjct: 169 DGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPD----GSLAASAGKD 224 Query: 238 GRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT---EEKAELQSNLQV 294 G+I ++ + K + ++ S + E L L+ Sbjct: 225 GQIYVWNLKHKS-AFMNFDAKDEVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKP 283 Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 E + S++W+ G L + D +R+W+ Sbjct: 284 EFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Score = 65.8 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 37/291 (12%), Positives = 87/291 (29%), Gaps = 76/291 (26%) Query: 47 LSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLND 106 L + H+ + ++ ++ + ++ S S DKT+ W ++++ + + Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQP-NLLVSGSRDKTLISWRLTENEQQ----FGVPVRSYKG 64 Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 + V + G D LRL++ + + H Sbjct: 65 HSHIVQDVVVSAD--GNYAVSASWDKTLRLWNLATGNSEARFV-------------GHTG 109 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGR 226 ++ S + ++ S + ++ D A L GH + + AP Sbjct: 110 DVLSVAID--ANSSKIISASRDKTIRVWNTVGD----CAYVLLGHTDWVTKVRVAPKNLE 163 Query: 227 WYQL------IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 ++ + D +R + + E Sbjct: 164 DGEVDDGRITFVSAGMDKIVRSWSLNEDSY------------------------------ 193 Query: 281 NTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + ++ HN + V + G++ +SAG DG++ +W Sbjct: 194 --------------RIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVW 230 >5M25-A nrPDB Length = 434 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 55/334 (16%), Positives = 113/334 (33%), Gaps = 47/334 (14%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V V + G +A+ S+D+ IK++ + + + H I + W+S Sbjct: 142 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSS 197 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 ++ SAS DKT+K+W+ L TL ++ F P + Sbjct: 198 D--SNLLVSASDDKTLKIWDVSSG---------KCLKTLKGHSNYVFCCNFNPQSN--LI 244 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 D +R++D L++ H + + R ++ Sbjct: 245 VSGSFDESVRIWDVKTGKCLKTLPA-------------HSDPVSAVHFN--RDGSLIVSS 289 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 S I+ L + + + ++P+ G++ I D ++++ Sbjct: 290 SYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPN-GKY---ILAATLDNTLKLWDY 343 Query: 246 TEKLSPLASEESLTNSNMFDNSADVD---MDAQGRSDSNTEEKAELQSNLQVELLSEHDD 302 ++ + V G D+ E++ + Sbjct: 344 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT----KEIVQKLQG 399 Query: 303 HNGEVWSVSWNLTGTILSSAG--DDGKVRLWKAT 334 H V S + + T I++SA +D ++LWK+ Sbjct: 400 HTDVVISTACHPTENIIASAALENDKTIKLWKSD 433 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 48/295 (16%), Positives = 100/295 (33%), Gaps = 45/295 (15%) Query: 42 TSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKL 101 N+ L + H ++ ++ ++ G +AS+S DK +K+W + E Sbjct: 132 KPNYALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFE--------- 180 Query: 102 CTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP 161 T++ K + V ++ L +D L+++D L++ Sbjct: 181 KTISGHKLGISDVAWSSDSN--LLVSASDDKTLKIWDVSSGKCLKTL------------- 225 Query: 162 ANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKL-HVAAKLPGHKSLIRSISW 220 H FC ++ P + + ++++ R D K LP H + ++ + Sbjct: 226 KGHSNYVFCCNFNP---QSNLIVSGSFDESV---RIWDVKTGKCLKTLPAHSDPVSAVHF 279 Query: 221 APSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS-EESLTNSNMFDNSADVDMDAQGRSD 279 R LI + DG RI+ ++ + S + D Sbjct: 280 N----RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 335 Query: 280 SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT---GTILSSAGDDGKVRLW 331 + + + L + H E + + N + G + S +D V +W Sbjct: 336 NTLKLWDYSKGKC----LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 386 >5OPT-p nrPDB Length = 318 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 58/336 (17%), Positives = 111/336 (33%), Gaps = 45/336 (13%) Query: 7 GHDDLVHDVV---YDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDS-----WRAHDSSI 58 GH V + + S D + + + D ++ E H + + Sbjct: 11 GHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFV 70 Query: 59 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 + A G SAS+D +++LW + + SV F+P Sbjct: 71 SDV--ALSNNGDFAVSASWDHSLRLWNLQTGVCQ---------HKFLGHTKDVLSVTFSP 119 Query: 119 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 178 + ++ G D LR+++ + ++ H C+ + PS Sbjct: 120 DNR--QIVSGGRDNALRVWNVKGE------------CLHTLGRGAHTDWVSCVRFSPSLE 165 Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 +P ++ ++ L L GH + I S++ +P L A+ KDG Sbjct: 166 TPLIVSGGWDNLVKVWDIASGRLLT---DLKGHTNYITSVTVSPD----GSLCASSDKDG 218 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT---EEKAELQSNLQVE 295 R++ +T+ L+ + N S + E ++ L E Sbjct: 219 VARLWDLTKG-EALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPE 277 Query: 296 LLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + E S++W+ G L S D +R+W Sbjct: 278 AQQKSKKTP-ECMSIAWSADGNTLYSGYTDNVIRVW 312 Score = 107 bits (265), Expect = 9e-24, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 77/241 (31%), Gaps = 31/241 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V V + R + + D ++V+ + + L AH + + ++ Sbjct: 107 GHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGEC-LHTLGRG--AHTDWVSCVRFSPS 163 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 +I S +D VK+W+ L L + SV +P G A Sbjct: 164 LETPLIVSGGWDNLVKVWDI---------ASGRLLTDLKGHTNYITSVTVSPD--GSLCA 212 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 DG+ RL+D + L + + + P + K + Sbjct: 213 SSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIV 272 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 L + K + SI+W+ + +G D IR++ ++ Sbjct: 273 ELAPEAQQKSKKTPECM-------------SIAWSAD----GNTLYSGYTDNVIRVWSVS 315 Query: 247 E 247 E Sbjct: 316 E 316 >5XYI-g nrPDB Length = 335 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 46/333 (13%), Positives = 116/333 (34%), Gaps = 39/333 (11%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDS-WRAHDSSIVAIDWAS 65 GH+ + + D ++ + S D+ V+KL++ W + H+ + + Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSL-- 88 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + ++S+D T++LW+ + K + V F+P + ++ Sbjct: 89 SRDASHLLTSSWDSTLRLWDLSTRTTK---------KLFLGHKKDVLGVTFSPCNR--RI 137 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP-SRFSPEKLA 184 +G D +++++ L +E++ S ++ P + + + Sbjct: 138 ISVGRDNQVKIWNILGE-------NKAELQCSS--------WVTSVACAPMADETSPLVI 182 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 +Y + + + + H S+ + P G+W + TG D ++ ++ Sbjct: 183 AVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPD-GKW---VITGGSDRKVVMWL 238 Query: 245 ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHN 304 ++ + + A + Q V+ +H+ Sbjct: 239 TENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKR 298 Query: 305 G-----EVWSVSWNLTGTILSSAGDDGKVRLWK 332 + ++W G++L S +DG +R W+ Sbjct: 299 NAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWE 331 Score = 70.4 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 40/241 (16%), Positives = 80/241 (33%), Gaps = 26/241 (10%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V V + R + + D +K++ + + SW +S+ A Sbjct: 120 GHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWV---TSVACAPMADE 176 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 +IA +D V +W + + + G SV F P G + Sbjct: 177 TSPLVIAVGCWDGKVYIWSIEKEA--------KLIKEFKAHDGRCTSVDFTPD--GKWVI 226 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 G+D + ++ + S+T S + ++ P ++ + Sbjct: 227 TGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPTQ--AWICAATYEGIAV----WDIG 280 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 A +Q + Q + A G ++WA ++ +G DG IR +++ Sbjct: 281 AKQQIDLVQPNFKHEGKRNA---GRTPDCTCLAWAAD----GSVLYSGYNDGSIRAWEVK 333 Query: 247 E 247 Sbjct: 334 S 334 >5WLC-LO nrPDB Length = 923 Score = 113 bits (283), Expect = 8e-26, Method: Composition-based stats. Identities = 55/348 (15%), Positives = 120/348 (34%), Gaps = 50/348 (14%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH + + + R + T S D K++ +D + N + ++ H ++ + Sbjct: 141 VHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLA-ATTFNGHRDYVMGAFF 199 Query: 64 ASPEYGRIIASASYDKTVKLWE------------------EDPDQEECSGRRWNKLCTLN 105 + + I + S D V +WE ++ R K Sbjct: 200 SHDQEK--IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFY 257 Query: 106 DSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHL 165 ++ + V F PA LA G RLYD + + ++ ++ P N + Sbjct: 258 ANQAKVKCVTFHPATR--LLAVGFTSGEFRLYDLPDFTLIQQLSM-------GQNPVNTV 308 Query: 166 QSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 225 + W LA + + + + ++ K GH S++++P Sbjct: 309 SVNQTGEW---------LAFGSSKLGQLLVYEWQSESYIL-KQQGHFDSTNSLAYSPDGS 358 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 R + T +DG+I+++ IT EE ++ + + D Sbjct: 359 R----VVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 414 Query: 286 AELQ-SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDG-KVRLW 331 ++ N + +E N ++ + +G ++ + D + +W Sbjct: 415 DLIRYRNFRTFTGTERIQFN----CLAVDPSGEVVCAGSLDNFDIHVW 458 Score = 105 bits (261), Expect = 3e-23, Method: Composition-based stats. Identities = 61/372 (16%), Positives = 125/372 (33%), Gaps = 66/372 (17%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + + Y G V T S D IKV+ + ++ H SS+ A+ +A Sbjct: 343 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITS----GFCLATFEEHTSSVTAVQFA-- 396 Query: 67 EYGRIIASASYDKTVKLWE-----------------------EDPDQEECSG-------- 95 + G+++ S+S D TV+ W+ + + C+G Sbjct: 397 KRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIH 456 Query: 96 ----RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA-LEPSDLRSWTL 150 + L L+ +G + + F+ LA D +R++ + + Sbjct: 457 VWSVQTGQLLDALSGHEGPVSCLSFS--QENSVLASASWDKTIRIWSIFGRSQQVEPIEV 514 Query: 151 TSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKL---HVAAK 207 S++ LS+ P + L S F+ E + + G+ AK Sbjct: 515 YSDVLALSMRPDGKEVAVSTLKGQISIFNIEDA--KQVGNIDCRKDIISGRFNQDRFTAK 572 Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS--------EESLT 259 +I ++ I G + I ++ + ++ +L Sbjct: 573 NSERSKFFTTIHYS----FDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLE 628 Query: 260 NSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ-----VELLSEHDDHNGEVWSVSWNL 314 N + +D + N++ + + ++L +L + V SV ++ Sbjct: 629 FLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSP 688 Query: 315 TGTILSSAGDDG 326 T ++A +G Sbjct: 689 TANAFAAASTEG 700 Score = 71.6 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 41/344 (11%), Positives = 116/344 (33%), Gaps = 35/344 (10%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 62 F+ H + + + G + + D + + + A+ Sbjct: 49 TFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEK-----CSAVK 103 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 ++ GR+ A AS + +++W+ ++ + + + S+ ++ Sbjct: 104 FSPD--GRLFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSR- 159 Query: 123 LKLACLGNDGILRLY--DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF-- 178 + D +++ D+ E + + V+ ++ + + +S + F Sbjct: 160 -FILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVW 218 Query: 179 ----------SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWY 228 E E+ I + ++ +++ ++ +++ P Sbjct: 219 EFTKRPSDDDDNESEDDDKQEEVDISKYSW--RITKKHFFYANQAKVKCVTFHP----AT 272 Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 +L+A G G R++ + + N + + A G ++ L Sbjct: 273 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGS----SKLGQLL 328 Query: 289 QSNLQVEL-LSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 Q E + + H S++++ G+ + +A +DGK+++W Sbjct: 329 VYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 372 Score = 52.3 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 42/320 (13%), Positives = 106/320 (33%), Gaps = 49/320 (15%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH+ V + + +A+ S D+ I+++ + + E + + S ++A+ Sbjct: 470 SGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVY----SDVLALSMRP 525 Query: 66 PEYGRIIASASYDKTVKLWEEDP---------DQEECSGRRWNKLCTLNDSKGSLYSVKF 116 G+ +A ++ + ++ + ++ SGR T +S+ S + Sbjct: 526 D--GKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTI 583 Query: 117 APAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPS 176 + G+ + GN+ + LYD L+ + ++ M + Sbjct: 584 HYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLE--------------F 629 Query: 177 RFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKS-------------LIRSISWAPS 223 S + +L+ D + + LPG + + S+ ++P+ Sbjct: 630 LNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPT 689 Query: 224 IGRWYQLIATGCKDGRIRIFKITEKL--SPLASEESLTNSNMFDNSADVDMDAQGRSDSN 281 A +G + I+ + + P + +T + + + Sbjct: 690 ----ANAFAAASTEG-LLIYSTNDTILFDPFDLDVDVTPHSTVEALREKQFLNALVMAFR 744 Query: 282 TEEKAELQSNLQVELLSEHD 301 E+ + + + E Sbjct: 745 LNEEYLINKVYEAIPIKEIP 764 >2H9P-A nrPDB Length = 329 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 55/334 (16%), Positives = 113/334 (33%), Gaps = 47/334 (14%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V V + G +A+ S+D+ IK++ + + + H I + W+S Sbjct: 37 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY----DGKFEKTISGHKLGISDVAWSS 92 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 ++ SAS DKT+K+W+ L TL ++ F P + Sbjct: 93 D--SNLLVSASDDKTLKIWDVSSG---------KCLKTLKGHSNYVFCCNFNPQSN--LI 139 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 D +R++D L++ H + + R ++ Sbjct: 140 VSGSFDESVRIWDVKTGKCLKTLPA-------------HSDPVSAVHFN--RDGSLIVSS 184 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 S I+ L + + + ++P+ G++ I D ++++ Sbjct: 185 SYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPN-GKY---ILAATLDNTLKLWDY 238 Query: 246 TEKLSPLASEESLTNSNMFDNSADVD---MDAQGRSDSNTEEKAELQSNLQVELLSEHDD 302 ++ + V G D+ E++ + Sbjct: 239 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT----KEIVQKLQG 294 Query: 303 HNGEVWSVSWNLTGTILSSAG--DDGKVRLWKAT 334 H V S + + T I++SA +D ++LWK+ Sbjct: 295 HTDVVISTACHPTENIIASAALENDKTIKLWKSD 328 Score = 96.6 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 48/295 (16%), Positives = 100/295 (33%), Gaps = 45/295 (15%) Query: 42 TSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKL 101 N+ L + H ++ ++ ++ G +AS+S DK +K+W + E Sbjct: 27 KPNYALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFE--------- 75 Query: 102 CTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP 161 T++ K + V ++ L +D L+++D L++ Sbjct: 76 KTISGHKLGISDVAWSSDSN--LLVSASDDKTLKIWDVSSGKCLKTL------------- 120 Query: 162 ANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKL-HVAAKLPGHKSLIRSISW 220 H FC ++ P + + ++++ R D K LP H + ++ + Sbjct: 121 KGHSNYVFCCNFNP---QSNLIVSGSFDESV---RIWDVKTGKCLKTLPAHSDPVSAVHF 174 Query: 221 APSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS-EESLTNSNMFDNSADVDMDAQGRSD 279 R LI + DG RI+ ++ + S + D Sbjct: 175 N----RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 230 Query: 280 SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT---GTILSSAGDDGKVRLW 331 + + + L + H E + + N + G + S +D V +W Sbjct: 231 NTLKLWDYSKGKC----LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIW 281 >5I2T-A nrPDB Length = 742 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 55/348 (15%), Positives = 120/348 (34%), Gaps = 50/348 (14%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 +GH + + + R + T S D K++ +D + N + ++ H ++ + Sbjct: 166 VHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLA-ATTFNGHRDYVMGAFF 224 Query: 64 ASPEYGRIIASASYDKTVKLWE------------------EDPDQEECSGRRWNKLCTLN 105 + + I + S D V +WE ++ R K Sbjct: 225 SHDQEK--IYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFY 282 Query: 106 DSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHL 165 ++ + V F PA LA G RLYD + + ++ ++ P N + Sbjct: 283 ANQAKVKCVTFHPATR--LLAVGFTSGEFRLYDLPDFTLIQQLSM-------GQNPVNTV 333 Query: 166 QSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 225 + W LA + + + + ++ K GH S++++P Sbjct: 334 SVNQTGEW---------LAFGSSKLGQLLVYEWQSESYIL-KQQGHFDSTNSLAYSPDGS 383 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 R + T +DG+I+++ IT EE ++ + + D Sbjct: 384 R----VVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 439 Query: 286 AELQ-SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDG-KVRLW 331 ++ N + +E N ++ + +G ++ + D + +W Sbjct: 440 DLIRYRNFRTFTGTERIQFN----CLAVDPSGEVVCAGSLDNFDIHVW 483 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 62/372 (16%), Positives = 122/372 (32%), Gaps = 66/372 (17%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + + Y G V T S D IKV+ + ++ H SS+ A+ +A Sbjct: 368 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITS----GFCLATFEEHTSSVTAVQFA-- 421 Query: 67 EYGRIIASASYDKTVKLWEE----------------------DPDQEECSGR-------- 96 + G+++ S+S D TV+ W+ DP E Sbjct: 422 KRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIH 481 Query: 97 -----RWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA-LEPSDLRSWTL 150 L L+ +G + + F+ LA D +R++ + + Sbjct: 482 VWSVQTGQLLDALSGHEGPVSCLSFS--QENSVLASASWDKTIRIWSIFGRSQQVEPIEV 539 Query: 151 TSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKL---HVAAK 207 S++ LS+ P + L S F+ E + + G+ AK Sbjct: 540 YSDVLALSMRPDGKEVAVSTLKGQISIFNIEDA--KQVGNIDCRKDIISGRFNQDRFTAK 597 Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS--------EESLT 259 +I ++ I G + I ++ + ++ +L Sbjct: 598 NSERSKFFTTIHYS----FDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLE 653 Query: 260 NSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ-----VELLSEHDDHNGEVWSVSWNL 314 N + +D + N++ + + ++L +L + V SV ++ Sbjct: 654 FLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSP 713 Query: 315 TGTILSSAGDDG 326 T ++A +G Sbjct: 714 TANAFAAASTEG 725 Score = 70.4 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 41/344 (11%), Positives = 116/344 (33%), Gaps = 35/344 (10%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 62 F+ H + + + G + + D + + + A+ Sbjct: 74 TFEYEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEK-----CSAVK 128 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 ++ GR+ A AS + +++W+ ++ + + + S+ ++ Sbjct: 129 FSPD--GRLFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSR- 184 Query: 123 LKLACLGNDGILRLY--DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF-- 178 + D +++ D+ E + + V+ ++ + + +S + F Sbjct: 185 -FILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVW 243 Query: 179 ----------SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWY 228 E E+ I + ++ +++ ++ +++ P Sbjct: 244 EFTKRPSDDDDNESEDDDKQEEVDISKYSW--RITKKHFFYANQAKVKCVTFHP----AT 297 Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 +L+A G G R++ + + N + + A G ++ L Sbjct: 298 RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGS----SKLGQLL 353 Query: 289 QSNLQVEL-LSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 Q E + + H S++++ G+ + +A +DGK+++W Sbjct: 354 VYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 397 Score = 50.0 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 65/158 (41%), Gaps = 15/158 (9%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH+ V + + +A+ S D+ I+++ + + E + + S ++A+ Sbjct: 495 SGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVY----SDVLALSMRP 550 Query: 66 PEYGRIIASASYDKTVKLWEEDP---------DQEECSGRRWNKLCTLNDSKGSLYSVKF 116 G+ +A ++ + ++ + ++ SGR T +S+ S + Sbjct: 551 D--GKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTI 608 Query: 117 APAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEM 154 + G+ + GN+ + LYD L+ + ++ M Sbjct: 609 HYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNM 646 >6QX9-4B nrPDB Length = 522 Score = 110 bits (274), Expect = 9e-25, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 97/287 (33%), Gaps = 46/287 (16%) Query: 7 GHDDLVHDVVY--------DFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI 58 GH+ V +V+ D ++A+C++D +K++ LD D H + Sbjct: 271 GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEP----VADIEGHTVRV 326 Query: 59 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 + W GR + + YD++ +LW+ + +E +Y + F Sbjct: 327 ARVMWHPS--GRFLGTTCYDRSWRLWDLEAQEEILHQE---------GHSMGVYDIAF-- 373 Query: 119 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 178 G G D R++D + + HL+ + +++ P+ + Sbjct: 374 HQDGSLAGTGGLDAFGRVWDLRTGRCI-------------MFLEGHLKEIYGINFSPNGY 420 Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 +A + + + + +P H++L+ + + P G + TG D Sbjct: 421 H---IATGSGDN--TCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHG---NFLLTGAYDN 472 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 +I+ D S+D + A D + Sbjct: 473 TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 105 bits (260), Expect = 4e-23, Method: Composition-based stats. Identities = 52/335 (15%), Positives = 110/335 (32%), Gaps = 50/335 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 G D + + + +AT K++ + + L + R H++++ AI + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSV----PDCNLLHTLRGHNTNVGAIVFHPK 284 Query: 67 EYGRI------IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + +AS + D +VKLW D D + + + V + P+ Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSD---------EPVADIEGHTVRVARVMWHPS- 334 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 G L D RL+D ++ + H + +++ Sbjct: 335 -GRFLGTTCYDRSWRLWDLEAQEEI-------------LHQEGHSMGVYDIAFHQDG--- 377 Query: 181 EKLAVSALEQAIIYQRGKDGKL-HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 239 +++ + R D + L GH I I+++P+ IATG D Sbjct: 378 ---SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN----GYHIATGSGDNT 430 Query: 240 IRIFKITEKLSPLASEESLTNSNMFDNSA-DVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 +++ + ++ + G D+ + + L Sbjct: 431 CKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWS----PLK 486 Query: 299 EHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 H G+V + + G ++++ D +LW A Sbjct: 487 TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521 Score = 66.6 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 22/82 (26%), Positives = 41/82 (50%), Gaps = 7/82 (8%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 H +LV V ++ +G + T + D K++ W + H+ ++ +D +S Sbjct: 447 AHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT----HPGWSPLKTLAGHEGKVMGLDISS 502 Query: 66 PEYGRIIASASYDKTVKLWEED 87 G++IA+ SYD+T KLW + Sbjct: 503 D--GQLIATCSYDRTFKLWMAE 522 Score = 41.2 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 18/31 (58%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVF 36 +GH+ V + G+ +ATCS D+ K++ Sbjct: 489 AGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >4V7E-Bg nrPDB Length = 380 Score = 107 bits (266), Expect = 7e-24, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 108/334 (32%), Gaps = 35/334 (10%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V+ + + + + S D + V+ + + H ++ +A Sbjct: 64 GHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAI----KLHCPWVMECAFAPN 119 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G+ +A D ++ + +++ L KG S ++ P +L Sbjct: 120 --GQSVACGGLDSACSIFNLSSQADRDGNMPVSRV--LTGHKGYASSCQYVPDQE-TRLI 174 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D L+D + + P+ H LS + Sbjct: 175 TGSGDQTCVLWDVTTGQRISIFGSE--------FPSGHTADVLSLSIN--SLNANMFISG 224 Query: 187 ALEQAIIYQRGKDGKLHVAA--KLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 + + + R D ++ A GH+ I S+ + P Q TG DG R+F Sbjct: 225 SCDTTV---RLWDLRITSRAVRTYHGHEGDINSVKFFPD----GQRFGTGSDDGTCRLFD 277 Query: 245 ITE-------KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELL 297 + P ++ L S + G S+ + L + + + L Sbjct: 278 MRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLG 337 Query: 298 SEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + + H G + + + G+ L + D +++W Sbjct: 338 TLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 51.9 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 18/142 (12%), Positives = 50/142 (35%), Gaps = 12/142 (8%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSS---IVAIDW 63 GH+ ++ V + G+ T S D ++F + + +D+ + ++ + Sbjct: 247 GHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAF 306 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 + GR++ + + +W+ + + N +G + + + G Sbjct: 307 SIS--GRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQ-----NSHEGRISCLGLSSD--GS 357 Query: 124 KLACLGNDGILRLYDALEPSDL 145 L D L+++ + Sbjct: 358 ALCTGSWDKNLKIWAFSGHRKI 379 Score = 35.8 bits (80), Expect = 0.032, Method: Composition-based stats. Identities = 6/40 (15%), Positives = 17/40 (42%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDK 40 + + H+ + + G + T S D+++K++ Sbjct: 336 LGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSG 375 Score = 31.5 bits (69), Expect = 0.61, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 19/37 (51%) Query: 297 LSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 H+G+V+S+ W + SA DG++ +W A Sbjct: 59 CRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNA 95 >6N9G-C nrPDB Length = 353 Score = 103 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 54/327 (16%), Positives = 109/327 (33%), Gaps = 37/327 (11%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH + V + + R + + S D + V+ ++ ++A +A Sbjct: 61 GHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT----WVMACAYAPS 116 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G IA D ++ D+ E K ++ L + F + +++ Sbjct: 117 --GCAIACGGLDNKCSVYPLTFDKNE---NMAAKKKSVAMHTNYLSACSF--TNSDMQIL 169 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 DG L+D L+S+ H CL PS + Sbjct: 170 TASGDGTCALWDVESGQLLQSF-------------HGHGADVLCLDLAPS-ETGNTFVSG 215 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI- 245 ++ + + G+ H+S + S+ + PS A+G D R++ + Sbjct: 216 GCDKKAMVWDMRSGQ--CVQAFETHESDVNSVRYYPS----GDAFASGSDDATCRLYDLR 269 Query: 246 -TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHN 304 +++ + E + ++ D S + G +D L+ + L H Sbjct: 270 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILF----GHE 325 Query: 305 GEVWSVSWNLTGTILSSAGDDGKVRLW 331 V ++ + GT S D +R+W Sbjct: 326 NRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 28.1 bits (60), Expect = 5.9, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 18/38 (47%) Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNE 338 H +V + W + S+ DGKV +W + +N+ Sbjct: 60 KGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNK 97 >5YZG-W nrPDB Length = 579 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 62/334 (18%), Positives = 116/334 (34%), Gaps = 48/334 (14%) Query: 6 SGHDDLVHDV-VYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 SGH V V ++ G + +CS D IK++++ + ++ H ++ I + Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER---RCLRTFIGHSKAVRDICF- 340 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 G SA+YD+ +KLW+ + Q C R N+ Y VKF P Sbjct: 341 -NTAGTQFLSAAYDRYLKLWDTETGQ--CISRFTNRKVP--------YCVKFNPDEDKQN 389 Query: 125 LACLG-NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 L G +D + +D ++ + HL + + + + + Sbjct: 390 LFVAGMSDKKIVQWDIRSGEIVQEYD-------------RHLGAVNTIVF--VDENRRFV 434 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 + S + +++ A+ H ++ +P+ G+W +A D +I IF Sbjct: 435 STSDDKSLRVWEWDIPVDFKYIAEPSMHSMPA--VTLSPN-GKW---LACQSMDNQILIF 488 Query: 244 K-----ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 K + D S D+ G + + L S Sbjct: 489 GAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTK----LYS 544 Query: 299 EHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLW 331 H+ W+ T + + G DG ++LW Sbjct: 545 RFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 578 Score = 70.4 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 38/285 (13%), Positives = 94/285 (32%), Gaps = 40/285 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V D+ ++ G + + D+++K++ DT + + + + Sbjct: 330 GHSKAVRDICFNTAGTQFLSAAYDRYLKLW----DTETGQCISRFTNRKVP-YCVKFNPD 384 Query: 67 EYGRIIASASY-DKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 E + + A DK + W+ R + + G++ ++ F + + Sbjct: 385 EDKQNLFVAGMSDKKIVQWDI---------RSGEIVQEYDRHLGAVNTIVFVDENR--RF 433 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 +D LR+++ W + + K ++ P+ H LS + + LA Sbjct: 434 VSTSDDKSLRVWE---------WDIPVDFKYIA-EPSMHSMPAVTLS-----PNGKWLAC 478 Query: 186 SALEQAI-IYQRGKDGKLHVAAKLPGH--KSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 +++ I I+ +L+ GH + ++P + + +G +G++ I Sbjct: 479 QSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDM----SYVISGDGNGKLNI 534 Query: 243 FKITEKLSPLASEESLTNSNMFDNSA-DVDMDAQGRSDSNTEEKA 286 + + + D + Sbjct: 535 WDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 48.9 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 26/182 (14%), Positives = 60/182 (32%), Gaps = 9/182 (4%) Query: 162 ANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWA 221 + H + + P L+ S + +++ G+ GH +R I + Sbjct: 285 SGHTKGVSAVRLFPLSGH-LLLSCSMDCKIKLWE--VYGERRCLRTFIGHSKAVRDICFN 341 Query: 222 PSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 281 + + + D ++++ + D D Sbjct: 342 TAGTQ----FLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDED-KQNLFVAGM 395 Query: 282 TEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKC 341 +++K E++ E+D H G V ++ + S DD +R+W+ +FK Sbjct: 396 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKY 455 Query: 342 MS 343 ++ Sbjct: 456 IA 457 >6QDV-o nrPDB Length = 513 Score = 102 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 62/334 (18%), Positives = 116/334 (34%), Gaps = 48/334 (14%) Query: 6 SGHDDLVHDV-VYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 SGH V V ++ G + +CS D IK++++ + ++ H ++ I + Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER---RCLRTFIGHSKAVRDICF- 274 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 G SA+YD+ +KLW+ + Q C R N+ Y VKF P Sbjct: 275 -NTAGTQFLSAAYDRYLKLWDTETGQ--CISRFTNRKVP--------YCVKFNPDEDKQN 323 Query: 125 LACLG-NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 L G +D + +D ++ + HL + + + + + Sbjct: 324 LFVAGMSDKKIVQWDIRSGEIVQEYD-------------RHLGAVNTIVF--VDENRRFV 368 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 + S + +++ A+ H ++ +P+ G+W +A D +I IF Sbjct: 369 STSDDKSLRVWEWDIPVDFKYIAEPSMHSMPA--VTLSPN-GKW---LACQSMDNQILIF 422 Query: 244 K-----ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 K + D S D+ G + + L S Sbjct: 423 GAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTK----LYS 478 Query: 299 EHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLW 331 H+ W+ T + + G DG ++LW Sbjct: 479 RFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLW 512 Score = 70.0 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 37/285 (12%), Positives = 93/285 (32%), Gaps = 40/285 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V D+ ++ G + + D+++K++ DT + + + + Sbjct: 264 GHSKAVRDICFNTAGTQFLSAAYDRYLKLW----DTETGQCISRFTNRKVP-YCVKFNPD 318 Query: 67 E-YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 E + + DK + W+ R + + G++ ++ F + + Sbjct: 319 EDKQNLFVAGMSDKKIVQWDI---------RSGEIVQEYDRHLGAVNTIVFVDENR--RF 367 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 +D LR+++ W + + K ++ P+ H LS + + LA Sbjct: 368 VSTSDDKSLRVWE---------WDIPVDFKYIA-EPSMHSMPAVTLS-----PNGKWLAC 412 Query: 186 SALEQAI-IYQRGKDGKLHVAAKLPGH--KSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 +++ I I+ +L+ GH + ++P + + +G +G++ I Sbjct: 413 QSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDM----SYVISGDGNGKLNI 468 Query: 243 FKITEKLSPLASEESLTNSNMFDNSA-DVDMDAQGRSDSNTEEKA 286 + + + D + Sbjct: 469 WDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 48.5 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 26/182 (14%), Positives = 58/182 (31%), Gaps = 9/182 (4%) Query: 162 ANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWA 221 + H + + P L+ S + +++ G+ GH +R I + Sbjct: 219 SGHTKGVSAVRLFPLSGH-LLLSCSMDCKIKLWE--VYGERRCLRTFIGHSKAVRDICFN 275 Query: 222 PSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN 281 + D ++++ + D D Sbjct: 276 ----TAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDED-KQNLFVAGM 329 Query: 282 TEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKC 341 +++K E++ E+D H G V ++ + S DD +R+W+ +FK Sbjct: 330 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKY 389 Query: 342 MS 343 ++ Sbjct: 390 IA 391 >5WYJ-BC nrPDB Length = 817 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 102/286 (35%), Gaps = 20/286 (6%) Query: 48 SDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDS 107 + + H+ + ++D + E G IA+AS D T +W + + C + K + + Sbjct: 381 VEIYEGHEDLLNSLD--ATEDGLWIATASKDNTAIVWRYNENS--CKFDIYAKYIGHSAA 436 Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 ++ L ND ++ + +P+ + +KV H + Sbjct: 437 VTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQI---IKVSEYTRHAHEKD 493 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW 227 LS P + A ++ ++ ++G+L A L HK + +S+ ++ Sbjct: 494 INALSVSP---NDSIFATASYDKTCKIWNLENGEL--EATLANHKRGLWDVSFC----QY 544 Query: 228 YQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE 287 +L+AT D ++I+ + E +D + Sbjct: 545 DKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDC 604 Query: 288 LQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 L D HN +W++S G ++ SA DG + WK Sbjct: 605 SSGEC----LKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKD 646 Score = 97.0 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 48/310 (15%), Positives = 108/310 (34%), Gaps = 30/310 (9%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 GH+DL++ + G +AT S D V++ ++++ +++ + H +++ A+ Sbjct: 381 VEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAV 440 Query: 62 DW---ASPEYGRIIASASYDKTVKLW--EEDPDQEECSGRRWNKLCTLNDSKGSLYSVKF 116 S Y + +AS D T+K W + + + ++ + + ++ Sbjct: 441 GLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHA-HEKDINALSV 499 Query: 117 APAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPS 176 +P A D ++++ L ANH + + +S+C Sbjct: 500 SPND--SIFATASYDKTCKIWNLENGE-------------LEATLANHKRGLWDVSFC-- 542 Query: 177 RFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCK 236 ++ S + I+ + L GH + ++ S+ I + QLI + Sbjct: 543 QYDKLLATSSGDKTVKIWSLDTFSVMK---TLEGHTNAVQRCSF---INKQKQLI-SCGA 595 Query: 237 DGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVEL 296 DG I+I+ + + D DM +D + + E Sbjct: 596 DGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEE 655 Query: 297 LSEHDDHNGE 306 + + Sbjct: 656 QEKAKLQVEQ 665 Score = 53.5 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 54/397 (13%), Positives = 119/397 (29%), Gaps = 102/397 (25%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDK----------------------- 40 + + + + G+++ S Q +K+F L Sbjct: 56 ISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTST 115 Query: 41 --------------DTSNWELSDSWRAHDSSIVAIDWASPEYGRI--IASASYDKTVKLW 84 D N ++ S++ H +I ++ + +I +AS + VK+W Sbjct: 116 LLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVW 175 Query: 85 EEDPDQEECSGRRWNKLCTLNDSKGSLYSVKF----APAHLGLKLACLGNDGILRLYD-- 138 + L TL + ++ + L L G D I+ L+D Sbjct: 176 DLVKR---------KCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFN 226 Query: 139 ---------------------ALEPSDLRSWTLTSEMKVLSIPPANHLQSD--------- 168 L+ D + T+ + + S Sbjct: 227 MKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIE 286 Query: 169 --FCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGK-----LHVAAKLPGHKSLIRSISWA 221 F + P + + V + + + +D K + V + + G+ +I + + Sbjct: 287 ELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRY- 345 Query: 222 PSIGRWYQLIATGCKDGRIRIFKITEKLSPLA--------SEESLTNSNMFDNSADVDMD 273 +G +A +RI + + P A E N D + D Sbjct: 346 --VGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWI 403 Query: 274 AQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSV 310 A D+ +++ + ++ +++ H+ V +V Sbjct: 404 ATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAV 440 Score = 33.4 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 41/132 (31%), Gaps = 16/132 (12%) Query: 215 IRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDN----SADV 270 I S S+ L+A G DG I + I + + + ++ + Sbjct: 101 ISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKI 160 Query: 271 DMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW-------NLTGTILSSAG 323 + A G ++ + ++ L +H V + + +L S G Sbjct: 161 WLLASGDTNGMVKVWDLVKRKC----LHTLQEHTSAVRGLDIIEVPDNDEPSLNLL-SGG 215 Query: 324 DDGKVRLWKATY 335 D + LW Sbjct: 216 RDDIINLWDFNM 227 >6GMH-W nrPDB Length = 305 Score = 101 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 65/331 (19%), Positives = 123/331 (37%), Gaps = 45/331 (13%) Query: 5 DSGHDDLVHDVVYDFYGRH----VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 + HDD + V + + V T S D +KV+K + +L S H +V+ Sbjct: 12 EQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDE--RLDLQWSLEGHQLGVVS 69 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +D + I AS+S D ++LW+ + ++ +++ +++ F+P Sbjct: 70 VDISHTL--PIAASSSLDAHIRLWDLENG---------KQIKSIDAGPVDAWTLAFSPDS 118 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 LA + G + ++ S + + +++ P Sbjct: 119 --QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL-------------SIAYSP---DG 160 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 + LA A++ I GKL L GH IRS++++P QL+ T DG I Sbjct: 161 KYLASGAIDGIINIFDIATGKLL--HTLEGHAMPIRSLTFSPD----SQLLVTASDDGYI 214 Query: 241 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 300 +I+ + + D SD + + + Sbjct: 215 KIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTC----VHTF 270 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 DH +VW V +N G+ + S GDD ++ ++ Sbjct: 271 FDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301 Score = 56.2 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 58/134 (43%), Gaps = 17/134 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH + + + + + T S D +IK++ + + L+ + H S ++ + + Sbjct: 188 GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV----QHANLAGTLSGHASWVLNVAFCPD 243 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + S+S DK+VK+W+ + T D + ++ VK+ G K+ Sbjct: 244 D--THFVSSSSDKSVKVWDVGTR---------TCVHTFFDHQDQVWGVKY--NGNGSKIV 290 Query: 127 CLGNDGILRLYDAL 140 +G+D + +YD Sbjct: 291 SVGDDQEIHIYDCP 304 Score = 36.9 bits (83), Expect = 0.012, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 33/81 (40%), Gaps = 6/81 (7%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V +V + H + SSD+ +KV+ + T D H + + + Sbjct: 229 SGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFD----HQDQVWGVKYNG 284 Query: 66 PEYGRIIASASYDKTVKLWEE 86 G I S D+ + +++ Sbjct: 285 N--GSKIVSVGDDQEIHIYDC 303 Score = 29.2 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 20/51 (39%), Gaps = 7/51 (13%) Query: 296 LLSEHDDHNGEVWSVSWNLTGT----ILSSAGDDGKVRLWK---ATYSNEF 339 L + H+ +WSV+W + + D V++WK ++ Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQW 58 >5OQL-J nrPDB Length = 912 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 44/307 (14%), Positives = 100/307 (32%), Gaps = 45/307 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW--- 63 GH+D+V + D+ G +A+ S D +++++D +++ + H S+ A+ Sbjct: 431 GHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKV 490 Query: 64 ASPEYGR-----------IIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLY 112 P + S S D+ V+ + D ++ G + + Sbjct: 491 VPPANSEAFKNPLDHPPAFLISGSQDRFVQ--KRDIPRQLQKGGKLTSSLRRLAHDKDIN 548 Query: 113 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLS 172 ++ +P G A D ++++D + + ++ H + + + Sbjct: 549 ALDISPN--GKLFASASQDKTVKIWD------VEKLEVQGILR-------GHKRGVWTVR 593 Query: 173 WCPSRFS---PEKLAVSALEQAIIYQRGKDGKL------HVAAKLPGHKSLIRSISWA-- 221 + P E+ +VS + K KL GH + + W Sbjct: 594 FAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHI 653 Query: 222 ---PSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRS 278 SI + A+ D ++++ + + + ++ A S Sbjct: 654 SRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGS 713 Query: 279 DSNTEEK 285 DS Sbjct: 714 DSKVTFW 720 Score = 97.4 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 65/373 (17%), Positives = 122/373 (32%), Gaps = 65/373 (17%) Query: 6 SGHDDLVHDVVYD-FYGRHVATCSSDQHIKVFKLDK----DTSNWEL---------SDSW 51 SG D + D+ Y +A ++ + I++ + N E Sbjct: 370 SGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALL 429 Query: 52 RAHDSSIV--AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKG 109 + H+ ++ +DW+ G IAS S D T +LW DP + + Sbjct: 430 KGHEDIVMSLDVDWS----GHWIASGSKDNTARLWRVDP-----ANNSYTCYAVFTGHLE 480 Query: 110 SLYSVKFAP--------------AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMK 155 S+ +V H L D ++ D+ Sbjct: 481 SVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQ------KRDIPRQLQKGGKL 534 Query: 156 VLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLI 215 S+ H + L P + + A ++ ++ + + KL V L GHK + Sbjct: 535 TSSLRRLAHDKDINALDISP---NGKLFASASQDKTV--KIWDVEKLEVQGILRGHKRGV 589 Query: 216 RSISWAPSIGRWYQ----------LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 265 ++ +AP Q ++ TG D I+++ +++ E N Sbjct: 590 WTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVV 649 Query: 266 NS--ADVDMDAQGRSDSNTEEKAELQSNLQV---ELLSEHDDHNGEVWSVSWNLTGTILS 320 + D + + + L E D+H +W+++ + IL+ Sbjct: 650 WLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILA 709 Query: 321 SAGDDGKVRLWKA 333 SAG D KV W+ Sbjct: 710 SAGSDSKVTFWRD 722 Score = 72.7 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 57/362 (15%), Positives = 121/362 (33%), Gaps = 57/362 (15%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H+ V + Y + + S D+ + ++ W+ + R H+ + ++ + Sbjct: 230 AHESNVQCIAYSPEQHALLSGSRDKTMTLW--LWRDGIWQGTPMLR-HE-LLESVGFL-- 283 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G+ + SA +++W+ E + S+G + L L Sbjct: 284 NEGKWMYSAGTSGVLRIWDTTTHHEITKKQD-------AKSEGEAILSAVSLPERSLIL- 335 Query: 127 CLGNDGILRLYDALEPSDLRSWT---LTSEMKVLSIPPANHLQSDFCL---SWCPSRFSP 180 C D L LY P+D+ S + L + +S L + L S + Sbjct: 336 CAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNS 395 Query: 181 EKLAVSALEQAIIYQRGKDGKL------HVAAKLPGHKSLIR--SISWAPSIGRWYQLIA 232 E + + +++ A Y H A L GH+ ++ + W+ IA Sbjct: 396 EDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS------GHWIA 449 Query: 233 TGCKDGRIRIFKITEKLSPLA----SEESLTNSNMFDNSA----------------DVDM 272 +G KD R++++ + L + Sbjct: 450 SGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAF 509 Query: 273 DAQGRSDSNTEEKA---ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVR 329 G D +++ +LQ ++ H+ ++ ++ + G + +SA D V+ Sbjct: 510 LISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVK 569 Query: 330 LW 331 +W Sbjct: 570 IW 571 Score = 53.9 bits (127), Expect = 9e-08, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 103/341 (30%), Gaps = 60/341 (17%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 +QP +G V + R +A+ + I + + + + I Sbjct: 17 IQPIYTG-----GSVALENGARILASTLGENAI-----LTELNTGKRLAEIQGDGEPIST 66 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + G + S T++++ + S + T + V A Sbjct: 67 LTITPS--GSHLIVCSRSLTMRIYSLAISPDYDSVEP-TLVRTTKPHATPV--VVLAVDR 121 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 LA DG ++++D + + + S + L + + Sbjct: 122 TSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVL-------------VSALHFFEIAVTA 168 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 E + + + + D +A++ ++W G +DGRI Sbjct: 169 ESQSSNKKPKKGSRKGQNDDADEIASRFR--------LAW-------------GTQDGRI 207 Query: 241 RIFKITEKLSPLAS-------EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ 293 RIF + ++ + E +N S + G D Q Sbjct: 208 RIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQ 267 Query: 294 VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 + H+ + SV + G + SAG G +R+W T Sbjct: 268 GTPMLRHE----LLESVGFLNEGKWMYSAGTSGVLRIWDTT 304 >6ID0-T nrPDB Length = 514 Score = 98.9 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 50/333 (15%), Positives = 111/333 (33%), Gaps = 45/333 (13%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + + T S+D+ IK++ L +L S H S++ + Sbjct: 201 SGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLAS----GKLKLSLTGHISTVRGV--IV 254 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + S DK VK W+ + + + + ++Y + P L Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYN---------KVIRHYHGHLSAVYGLDLHPTID--VL 303 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 D R++D + + + + N + + C + P ++ Sbjct: 304 VTCSRDSTARIWDVRTKASVHTLSG----------HTNAVATVRCQAAEP------QIIT 347 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + + I GK V L HK +R++ P + A+G D I+ +K Sbjct: 348 GSHDTTIRLWDLVAGKTRV--TLTNHKKSVRAVVLHP----RHYTFASGSPDN-IKQWKF 400 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHD---- 301 + N ++D + G + + + Sbjct: 401 PDGSFIQNLSGHNAIINTLTVNSD-GVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSL 459 Query: 302 DHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 D +++ +++ + + L +A D +++++ Sbjct: 460 DSESGIFACAFDQSESRLLTAEADKTIKVYRED 492 Score = 81.6 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 50/287 (17%), Positives = 94/287 (32%), Gaps = 41/287 (14%) Query: 45 WELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTL 104 W+L H + I + + S D+T+K+W+ + + S L Sbjct: 194 WKLYRVISGHLGWVRCIAVEP--GNQWFVTGSADRTIKIWDLASGKLKLS---------L 242 Query: 105 NDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANH 164 ++ V + L G D ++ +D +R + H Sbjct: 243 TGHISTVRGVIVS--TRSPYLFSCGEDKQVKCWDLEYNKVIRHY-------------HGH 287 Query: 165 LQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSI 224 L + + L P+ + S A I+ +H L GH + + ++ Sbjct: 288 LSAVYGLDLHPTI--DVLVTCSRDSTARIWDVRTKASVH---TLSGHTNAVATVR----C 338 Query: 225 GRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEE 284 I TG D IR++ + + + + A G D+ + Sbjct: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQW 398 Query: 285 KAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 K S +Q HN + +++ N G +L S D+G + LW Sbjct: 399 KFPDGSFIQ-----NLSGHNAIINTLTVNSDG-VLVSGADNGTMHLW 439 Score = 60.4 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 43/137 (31%), Gaps = 8/137 (5%) Query: 195 QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS 254 + + + GH +R I+ P Q TG D I+I+ + L+ Sbjct: 187 KPQWHPPWKLYRVISGHLGWVRCIAVEPGN----QWFVTGSADRTIKIWDLASGKLKLSL 242 Query: 255 EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL 314 ++ S D + +++ + H V+ + + Sbjct: 243 TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL----EYNKVIRHYHGHLSAVYGLDLHP 298 Query: 315 TGTILSSAGDDGKVRLW 331 T +L + D R+W Sbjct: 299 TIDVLVTCSRDSTARIW 315 Score = 30.8 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 23/80 (28%), Gaps = 4/80 (5%) Query: 256 ESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT 315 L G +D + L++ L H V V + Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLT----GHISTVRGVIVSTR 257 Query: 316 GTILSSAGDDGKVRLWKATY 335 L S G+D +V+ W Y Sbjct: 258 SPYLFSCGEDKQVKCWDLEY 277 Score = 30.0 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 18/41 (43%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWR 52 + +D + T +D+ IKV++ D + SW+ Sbjct: 465 IFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWK 505 >3MKQ-A nrPDB Length = 814 Score = 98.9 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 106/318 (33%), Gaps = 36/318 (11%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H D + + +V + S D +K++ + NW L ++ H+ ++ + + +P Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN---NWALEQTFEGHEHFVMCVAF-NP 150 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + AS D+TVK+W G+ + + V + P + Sbjct: 151 KDPSTFASGCLDRTVKVWSL--------GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMI 202 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +D ++++D S + + H+ + + P+ P ++ S Sbjct: 203 TASDDLTIKIWDYQTKSCVATLE-------------GHMSNVSFAVFHPTL--PIIISGS 247 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 I+ V L I+ P+ + Y IA+G D + + Sbjct: 248 EDGTLKIW---NSSTYKVEKTLNVGLERSWCIATHPTGRKNY--IASG-FDNGFTVLSLG 301 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 L+ + +A N E + + +LQ + L D Sbjct: 302 NDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQ- 360 Query: 307 VWSVSWNLTGTILSSAGD 324 S++ + G ++ GD Sbjct: 361 --SLAHSPNGRFVTVVGD 376 Score = 83.9 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 41/321 (12%), Positives = 98/321 (30%), Gaps = 42/321 (13%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 D V + + V T ++++ + + + Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSI------------QVTETPVRA 60 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 G+ IA ++ + + +D + K+ + S+ P + Sbjct: 61 GKFIARKNW---IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTK--PYVLSG 115 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSAL 188 +D ++L++ W L H C+++ P P A L Sbjct: 116 SDDLTVKLWN---------WENNW---ALEQTFEGHEHFVMCVAFNP--KDPSTFASGCL 161 Query: 189 EQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE 247 ++ + ++ G+ G + + + + P + Y + T D I+I+ Sbjct: 162 DRTVKVWSLGQSTPNFTLTT--GQERGVNYVDYYPLPDKPYMI--TASDDLTIKIWDYQT 217 Query: 248 KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEV 307 K E ++N + + + G D + ++ L + Sbjct: 218 KSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERS---- 273 Query: 308 WSVSWNLTG--TILSSAGDDG 326 W ++ + TG ++S D+G Sbjct: 274 WCIATHPTGRKNYIASGFDNG 294 Score = 44.2 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 22/139 (15%), Positives = 47/139 (33%), Gaps = 10/139 (7%) Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN 260 KL + ++ I + P+ + +G R+ I+ ++ + + + T Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSG----RVEIWNYETQVEVRSIQVTETP 57 Query: 261 SNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILS 320 A + G D V+ + H + S++ + T + Sbjct: 58 VRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVD----FEAHPDYIRSIAVHPTKPYVL 113 Query: 321 SAGDDGKVRLWKATYSNEF 339 S DD V+LW + N + Sbjct: 114 SGSDDLTVKLW--NWENNW 130 >3JB9-L nrPDB Length = 340 Score = 98.2 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 49/330 (14%), Positives = 105/330 (31%), Gaps = 47/330 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V +D G + A+ D+ I ++ + D N+ +I + W Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNY---GVLNGCKGAITDLQW--S 102 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 R++ +S D + W+ Q K+ G + ++ L Sbjct: 103 RDSRVVYCSSSDTHLMSWDAVSGQ---------KIRKHKGHAGVVNALDVLKV-GSELLT 152 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 + +D ++++D+ +++ + ++I + Sbjct: 153 SVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQG----------------TQVFIGG 196 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 I+ + H + L GHK +I S++ + + + + D +RIF + Sbjct: 197 IDGAIKIWDLRNN---HCSHVLKGHKDIITSLAIS----KDGSSLLSNSMDNTVRIFDVK 249 Query: 247 EKLSPLASEE------SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 300 S + N+ + + G S +K + +L Sbjct: 250 PFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSS---DKNVYVWSATGDLRYVL 306 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRL 330 H G V V ++ I+ S D + L Sbjct: 307 PGHEGSVNHVDFHPHQDIILSCSSDRTIFL 336 Score = 64.7 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 82/271 (30%), Gaps = 58/271 (21%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +G + D+ + R V SSD H+ + + + H + A+D Sbjct: 90 NGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVS----GQKIRKHKGHAGVVNALD-VL 144 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQ----------------------------------E 91 ++ S S D T+K+W+ Sbjct: 145 KVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIW 204 Query: 92 ECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLT 151 + + L K + S+ + G L D +R++D + + Sbjct: 205 DLRNNHCS--HVLKGHKDIITSLAISKD--GSSLLSNSMDNTVRIFDVKPFASAQR---- 256 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 ++ A H Q L SR S A S+ + ++ D + LPGH Sbjct: 257 ---QLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGD----LRYVLPGH 309 Query: 212 KSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 + + + + P +I + D I + Sbjct: 310 EGSVNHVDFHP----HQDIILSCSSDRTIFL 336 >5UZ7-B nrPDB Length = 351 Score = 97.8 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 98/327 (29%), Gaps = 42/327 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH ++ + + R + + S D + ++ + R S ++ +A Sbjct: 64 GHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI--PLR--SSWVMTCAYAPS 119 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G +A D ++ + R L G L +F + ++ Sbjct: 120 --GNYVACGGLDNICSIYNLKTREGNVRVSR-----ELAGHTGYLSCCRFLDDN---QIV 169 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D L+D E + H LS P Sbjct: 170 TSSGDTTCALWDI-------------ETGQQTTTFTGHTGDVMSLSLAPDT---RLFVSG 213 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI- 245 A + + ++G GH+S I +I + P+ ATG D R+F + Sbjct: 214 ACDASAKLWDVREG--MCRQTFTGHESDINAICFFPN----GNAFATGSDDATCRLFDLR 267 Query: 246 -TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHN 304 ++L + + + S + G D N L + + H+ Sbjct: 268 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL----KADRAGVLAGHD 323 Query: 305 GEVWSVSWNLTGTILSSAGDDGKVRLW 331 V + G +++ D +++W Sbjct: 324 NRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 77.0 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 42/279 (15%), Positives = 83/279 (29%), Gaps = 36/279 (12%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 V Y G +VA D ++ L N +S H + + Sbjct: 108 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ 167 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 I ++S D T LW+ + Q+ + G + S+ AP Sbjct: 168 ---IVTSSGDTTCALWDIETGQQTTTFTG---------HTGDVMSLSLAPDTR--LFVSG 213 Query: 129 GNDGILRLYDALEPSDLRSWTL-TSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 D +L+D E +++T S++ + P + + + A Sbjct: 214 ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNG-----NAFATGSDDATCRLFDLRA 268 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE 247 ++ + Y + G I S+S++ + +L+ G D ++ + Sbjct: 269 DQELMTYSHDN--------IICG----ITSVSFS----KSGRLLLAGYDDFNCNVWDALK 312 Query: 248 KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA 286 + + D A G DS + Sbjct: 313 ADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 55.4 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 48/136 (35%), Gaps = 21/136 (15%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH+ ++ + + G AT S D ++F L D + ++ Sbjct: 234 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQEL----------------MTYSH 277 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECS---GRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 I S S+ K+ +L D C+ + ++ L + + G Sbjct: 278 DNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV--TDDG 335 Query: 123 LKLACLGNDGILRLYD 138 + +A D L++++ Sbjct: 336 MAVATGSWDSFLKIWN 351 Score = 44.2 bits (102), Expect = 8e-05, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 44/131 (33%), Gaps = 5/131 (3%) Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN 260 ++ L GH + I ++ W G +L+ + +DG++ I+ A + Sbjct: 55 QMRTRRTLRGHLAKIYAMHW----GTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW 110 Query: 261 SNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILS 320 + + A G D+ V + E H G + + L + Sbjct: 111 VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIV 169 Query: 321 SAGDDGKVRLW 331 ++ D LW Sbjct: 170 TSSGDTTCALW 180 Score = 27.7 bits (59), Expect = 8.1, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 27/65 (41%), Gaps = 1/65 (1%) Query: 274 AQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 A T + +Q+ H +++++ W +L SA DGK+ +W + Sbjct: 37 ADATLSQITNNIDPVGR-IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDS 95 Query: 334 TYSNE 338 +N+ Sbjct: 96 YTTNK 100 >2YNP-A nrPDB Length = 604 Score = 96.2 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 50/318 (15%), Positives = 106/318 (33%), Gaps = 36/318 (11%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H D + + +V + S D +K++ + NW L ++ H+ ++ + + +P Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWEN---NWALEQTFEGHEHFVMCVAF-NP 150 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + AS D+TVK+W G+ + + V + P + Sbjct: 151 KDPSTFASGCLDRTVKVWSL--------GQSTPNFTLTTGQERGVNYVDYYPLPDKPYMI 202 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +D ++++D S + + H+ + + P+ P ++ S Sbjct: 203 TASDDLTIKIWDYQTKSCVATLE-------------GHMSNVSFAVFHPTL--PIIISGS 247 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 I+ V L I+ P+ + Y IA+G D + + Sbjct: 248 EDGTLKIW---NSSTYKVEKTLNVGLERSWCIATHPTGRKNY--IASG-FDNGFTVLSLG 301 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 L+ + +A N E + + +LQ + L D Sbjct: 302 NDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQ- 360 Query: 307 VWSVSWNLTGTILSSAGD 324 S++ + G ++ GD Sbjct: 361 --SLAHSPNGRFVTVVGD 376 Score = 80.8 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 41/321 (12%), Positives = 98/321 (30%), Gaps = 42/321 (13%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 D V + + V T ++++ + + + Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSI------------QVTETPVRA 60 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 G+ IA ++ + + +D + K+ + S+ P + Sbjct: 61 GKFIARKNW---IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTK--PYVLSG 115 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSAL 188 +D ++L++ W L H C+++ P P A L Sbjct: 116 SDDLTVKLWN---------WENNW---ALEQTFEGHEHFVMCVAFNP--KDPSTFASGCL 161 Query: 189 EQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE 247 ++ + ++ G+ G + + + + P + Y + T D I+I+ Sbjct: 162 DRTVKVWSLGQSTPNFTLTT--GQERGVNYVDYYPLPDKPYMI--TASDDLTIKIWDYQT 217 Query: 248 KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEV 307 K E ++N + + + G D + ++ L + Sbjct: 218 KSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERS---- 273 Query: 308 WSVSWNLTG--TILSSAGDDG 326 W ++ + TG ++S D+G Sbjct: 274 WCIATHPTGRKNYIASGFDNG 294 Score = 42.3 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 21/139 (15%), Positives = 47/139 (33%), Gaps = 10/139 (7%) Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN 260 KL + ++ I + P+ + +G R+ ++ ++ + + + T Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSG----RVELWNYETQVEVRSIQVTETP 57 Query: 261 SNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILS 320 A + G D V+ + H + S++ + T + Sbjct: 58 VRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVD----FEAHPDYIRSIAVHPTKPYVL 113 Query: 321 SAGDDGKVRLWKATYSNEF 339 S DD V+LW + N + Sbjct: 114 SGSDDLTVKLW--NWENNW 130 >5Y88-O nrPDB Length = 451 Score = 95.5 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 60/335 (17%), Positives = 114/335 (34%), Gaps = 47/335 (14%) Query: 6 SGHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 +GH V V D T S+D +KV+ L +L + H ++ + A Sbjct: 136 NGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLAT----GKLKTTLAGHVMTVRDV--A 189 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + + S S DKTVK W+ + +Q + + +V P Sbjct: 190 VSDRHPYLFSVSEDKTVKCWDLEKNQ---------IIRDYYGHLSGVRTVSIHPTLD--L 238 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 +A G D +++L+D ++ I H + P P+ ++ Sbjct: 239 IATAGRDSVIKLWDMR-------------TRIPVITLVGHKGPINQVQCTP--VDPQVVS 283 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 S ++ + V L HK +R+ + P +A+ C D IR + Sbjct: 284 SSTDATVRLWDVVAGKTMKV---LTHHKRSVRATALHP----KEFSVASACTDD-IRSWG 335 Query: 245 ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT-----EEKAELQSNLQVELLSE 299 + E E T + D+ G + + + QS E++ Sbjct: 336 LAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGS 395 Query: 300 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 + + +++ TG L + D +++WK Sbjct: 396 LEGERSVL-CSTFDKTGLRLITGEADKSIKIWKQD 429 Score = 82.0 bits (200), Expect = 3e-16, Method: Composition-based stats. Identities = 46/309 (14%), Positives = 99/309 (32%), Gaps = 51/309 (16%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH V DV ++ + S D+ +K + L+K+ ++ + H S + + Sbjct: 179 AGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKN----QIIRDYYGHLSGVRTVSIHP 234 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 +IA+A D +KLW+ + TL KG + V+ P ++ Sbjct: 235 TL--DLIATAGRDSVIKLWDMRTR---------IPVITLVGHKGPINQVQCTPVD--PQV 281 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFS-----P 180 D +RL+D + ++ T +H +S + P FS Sbjct: 282 VSSSTDATVRLWDVVAGKTMKVLT-------------HHKRSVRATALHPKEFSVASACT 328 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 + + L + + + K + L ++ + + G +G + Sbjct: 329 DDIRSWGLAEGSLLTNFESEKTGIINTLSINQDDV---------------LFAGGDNGVL 373 Query: 241 RIFKITEK-LSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSE 299 + + + S + S + T E + + + + Sbjct: 374 SFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETAT 433 Query: 300 HDDHNGEVW 308 + G W Sbjct: 434 KESEPGLAW 442 Score = 81.2 bits (198), Expect = 5e-16, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 94/290 (32%), Gaps = 45/290 (15%) Query: 45 WELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTL 104 W+LS H + + P + S D T+K+W+ + + TL Sbjct: 129 WKLSRVINGHLGWVRCVA-IDPVDNEWFITGSNDTTMKVWDLATGKLK---------TTL 178 Query: 105 NDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANH 164 ++ V + H L + D ++ +D + +R + H Sbjct: 179 AGHVMTVRDVAVSDRH--PYLFSVSEDKTVKCWDLEKNQIIRDY-------------YGH 223 Query: 165 LQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAA-KLPGHKSLIRSISWAPS 223 L +S P + + +A + + I + D + + L GHK I + P Sbjct: 224 LSGVRTVSIHP---TLDLIATAGRDSVI---KLWDMRTRIPVITLVGHKGPINQVQCTPV 277 Query: 224 IGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQ-GRSDSNT 282 + + D +R++ + + + A D + Sbjct: 278 ----DPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRS 333 Query: 283 EEKAELQSNLQVELLSEHDDHN-GEVWSVSWNLTGTILSSAGDDGKVRLW 331 A + LL+ + G + ++S N +L + GD+G + + Sbjct: 334 WGLA------EGSLLTNFESEKTGIINTLSINQD-DVLFAGGDNGVLSFY 376 Score = 58.5 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 27/184 (14%), Positives = 65/184 (35%), Gaps = 9/184 (4%) Query: 148 WTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAK 207 ++ S+ + H + + P E+L V+ E+ + + ++ Sbjct: 77 FSEASQAVISKKDHDTHASAFVNKIFQPEV--AEELIVNRYEKLLSQRPEWHAPWKLSRV 134 Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS 267 + GH +R ++ P W TG D ++++ + + S Sbjct: 135 INGHLGWVRCVAIDPVDNEW---FITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVS 191 Query: 268 ADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGK 327 D + + +++ ++ H V +VS + T ++++AG D Sbjct: 192 DRHPYLFSVSEDKTVKCWDL----EKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSV 247 Query: 328 VRLW 331 ++LW Sbjct: 248 IKLW 251 >5K0Y-T nrPDB Length = 329 Score = 91.6 bits (225), Expect = 4e-19, Method: Composition-based stats. Identities = 55/336 (16%), Positives = 114/336 (33%), Gaps = 44/336 (13%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI--DWA 64 GH+ + + Y+ G + T + D + V+ + N E ++ H ++ + DW Sbjct: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVW----YSVNGERLGTYMGHTGAVWCVDADWD 63 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH-LGL 123 + + + + S D + +LW+ + ++ + + + T + F+ +G Sbjct: 64 T----KHVLTGSADNSCRLWDCETGKQLALLKTNSAVRT-CGFDFGGNIIMFSTDKQMGY 118 Query: 124 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 + + +D +PS + + ++ W P + Sbjct: 119 QC-------FVSFFDLRDPSQIDNNEPYMKIPCND-------SKITSAVWGPLG----EC 160 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 ++ E + Q V + H I I + R + T KD ++F Sbjct: 161 IIAGHESGELNQY-SAKSGEVLVNVKEHSRQINDIQLS----REMTMFVTASKDNTAKLF 215 Query: 244 KITEK-------LSPLASEESLTNSN--MFDNSADVDMDAQGRSDSNTEEKAELQSNLQV 294 T P +L+ + + MD S + +A Sbjct: 216 DSTTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFE 275 Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRL 330 E H G + SV+++ G SS G+DG VR+ Sbjct: 276 EEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 39.2 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 35/117 (29%), Gaps = 9/117 (7%) Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS 267 L GH+ I I + R L+ T KD + ++ D Sbjct: 6 LQGHERSITQIKYN----REGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDAD 61 Query: 268 ADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGD 324 D G +D++ L + N V + ++ G I+ + D Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKT-----NSAVRTCGFDFGGNIIMFSTD 113 Score = 33.8 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 25/81 (30%), Gaps = 4/81 (4%) Query: 251 PLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSV 310 P+ + + + + D+ D + E L + H G VW V Sbjct: 3 PILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNG----ERLGTYMGHTGAVWCV 58 Query: 311 SWNLTGTILSSAGDDGKVRLW 331 + + + D RLW Sbjct: 59 DADWDTKHVLTGSADNSCRLW 79 >4U1E-I nrPDB Length = 347 Score = 90.1 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 60/338 (17%), Positives = 116/338 (34%), Gaps = 38/338 (11%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH+ + V Y+ G + +CS D V+ + N E + H +I +ID Sbjct: 7 TGHERPLTQVKYNKEGDLLFSCSKDSSASVW----YSLNGERLGTLDGHTGTIWSID--V 60 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + + + S D ++KLW+ Q + W + V+F+P L Sbjct: 61 DCFTKYCVTGSADYSIKLWDVSNGQCVAT---WKSPV-------PVKRVEFSPC-GNYFL 109 Query: 126 A----CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 A + N G + +Y+ S T SE + I L + W + Sbjct: 110 AILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWS----TKG 165 Query: 182 KLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIR 241 K ++ + I + + H+ I + ++P + T +D Sbjct: 166 KYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDL----TYFITSSRDTNSF 221 Query: 242 IFKITEKLSPLASEESLTNSNMFDNSADVDMDAQG---------RSDSNTEEKAELQSNL 292 + ++ E + + G S + + +A + Sbjct: 222 LVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKI 281 Query: 293 QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRL 330 E + H G + +V+ + GT +S G+DG +RL Sbjct: 282 FEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 >4XFV-A nrPDB Length = 792 Score = 89.7 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 47/326 (14%), Positives = 116/326 (35%), Gaps = 39/326 (11%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTV 81 + + + + I ++ + +N + + + H++ + + + + SAS D V Sbjct: 31 KKIVAFGAGKTIALWD-PIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 87 Query: 82 KLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALE 141 K+W+ + T+ ++ ++ P+ ++ DG + ++ Sbjct: 88 KIWKFTDYS------HLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISIWR--- 134 Query: 142 PSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-----IYQR 196 ++ CLS LA+ + I Sbjct: 135 ----QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 190 Query: 197 GKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 256 K V A+L GH+ ++S+++ L+ +G +D IR+++I SEE Sbjct: 191 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEE 250 Query: 257 SLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTG 316 S + + + + +++ + N + ++ H+ + S+ W+ + Sbjct: 251 D---------SKKLTLLSNKQYKFQIDDELRVGINFEALIM----GHDDWISSLQWHESR 297 Query: 317 TILSSAGDDGKVRLWK-ATYSNEFKC 341 L +A D + +W+ S + C Sbjct: 298 LQLLAATADTSLMVWEPDETSGIWVC 323 Score = 76.6 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 54/388 (13%), Positives = 108/388 (27%), Gaps = 95/388 (24%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH+ V V + + + S D H+K++K D S+ + + + + +IVA+ Sbjct: 61 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHLQCIQTIQHYSKTIVALSALPS 119 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKL------------------------- 101 +I+ D T+ +W ++ +E + Sbjct: 120 ----LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 175 Query: 102 ------------------------CTLNDSKGSLYSVKF--APAHLGLKLACLGNDGILR 135 L + + S+ F L D +R Sbjct: 176 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 235 Query: 136 LYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQ 195 L+ + S+ L Q D L Sbjct: 236 LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVG--------------------- 274 Query: 196 RGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGC-----KDGRIRIFKITEKLS 250 ++ A + GH I S+ W S + A D I+ + +L Sbjct: 275 ------INFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLG 328 Query: 251 PLASEESLTNSNMFDNSADVDMDAQGRSD-------SNTEEKAELQSNLQVELLSEHDDH 303 ++S+ + T + R D + + + N+ + Sbjct: 329 EMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGA 388 Query: 304 NGEVWSVSWNLTGTILSSAGDDGKVRLW 331 +V ++W+ +G L + D RL+ Sbjct: 389 TKDVTDIAWSPSGEYLLATSLDQTTRLF 416 Score = 72.7 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 81/247 (32%), Gaps = 23/247 (9%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIK--VFKLDKDTSNWELSDSWRAHDSSIVAIDWA 64 GH + + + +A+ +++ V ++ + E+ + H +I + + Sbjct: 560 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF- 618 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + G+ + S D+ LWE + + + ++ +AP G Sbjct: 619 -SKDGKFLLSVCRDRKWALWERNMED----NTFELRFKNEKPHTRIIWDADWAPLEFGNV 673 Query: 125 LACLGNDGILRLYD-ALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 D ++++ EP+D + + H ++ +S S + L Sbjct: 674 FVTASRDKTVKVWRHQKEPADDYVLEASIK----------HTKAVTAISIHDSMIREKIL 723 Query: 184 AVSALEQAIIYQRGKD-GKLHVAAKLP---GHKSLIRSISWAPSIGRWYQLIATGCKDGR 239 LE IY GK + +L I + W+ + G D Sbjct: 724 ISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLS 783 Query: 240 IRIFKIT 246 RI+ + Sbjct: 784 TRIYSLA 790 Score = 62.3 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 46/375 (12%), Positives = 114/375 (30%), Gaps = 56/375 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWEL-----------SDSWRAHD 55 GHDD + + + + ++D + V++ D+ + W + + Sbjct: 283 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 342 Query: 56 SSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVK 115 + W + E + + ++W ++ ++ + + + Sbjct: 343 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKD------NIICDQRLGISGATKDVTDIA 396 Query: 116 FAPAHLGLKLACLGNDGILRLY------DALEPSDLRSWTLTS--EMKVLSIPPANHLQS 167 ++P+ G L D RL+ + ++ +W S ++ + + Sbjct: 397 WSPS--GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD 454 Query: 168 DFCLSWCPS----RFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLP-------------- 209 +S F K L++ + Q + ++ +A +P Sbjct: 455 TRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDAN 514 Query: 210 -GHKSLIRSISWAPSIGRWYQLIATGCKDGRI---RIFKITEKLSPLASEESLTNSNMFD 265 + P I L+ + ++ ++ EKL D Sbjct: 515 EDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLY-----GHGFEITCLD 569 Query: 266 NSADVDMDAQGRSDSNTEEKAELQSNLQ--VELLSEHDDHNGEVWSVSWNLTGTILSSAG 323 S D + A +N + + + +E+ H+ + + ++ G L S Sbjct: 570 ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVC 629 Query: 324 DDGKVRLWKATYSNE 338 D K LW+ + Sbjct: 630 RDRKWALWERNMEDN 644 Score = 38.8 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 46/344 (13%), Positives = 99/344 (28%), Gaps = 59/344 (17%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFK--LDKDTSNWELSDSWRA------HDSS 57 SG V D+ + G ++ S DQ ++F + + +W H Sbjct: 386 SGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYD 445 Query: 58 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA 117 ++ ++ + S +K ++ ++ K + + S Sbjct: 446 MICVETVTDTR---FVSGGDEKILRSFDLPKG----VAGMLQKFVGIQFEEKS------- 491 Query: 118 PAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSR 177 + + + + + E + + L CP Sbjct: 492 ---------EMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPM 542 Query: 178 FSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKD 237 + + E +Y G + I + +P +LIA+ C+ Sbjct: 543 EDQLQRHLLWPEVEKLYGHGFE---------------ITCLDISPD----QKLIASACRS 583 Query: 238 G-----RIRIFKITE--KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQS 290 IRIF ++ P SLT + + + + + R + ++ Sbjct: 584 NNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMED 643 Query: 291 NLQVELLSEHDDHNGEVWSVSWNLT--GTILSSAGDDGKVRLWK 332 N H +W W G + +A D V++W+ Sbjct: 644 NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 687 Score = 33.8 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 33/97 (34%), Gaps = 1/97 (1%) Query: 249 LSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVW 308 ++P A + V + ++ N + + H EV Sbjct: 9 ITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPN-NKGVYATLKGHEAEVT 67 Query: 309 SVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 V + + SA +D V++WK T + +C+ I Sbjct: 68 CVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI 104 >3CFV-B nrPDB Length = 414 Score = 89.7 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 63/335 (18%), Positives = 118/335 (35%), Gaps = 64/335 (19%) Query: 8 HDDLVHDVVYDFYGRHVA---TCSSDQHIKVFKLDKD----TSNWELSDSWR--AHDSSI 58 H+ V+ Y H+ T SSD + VF K + E + R H Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSD--VLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 182 Query: 59 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 + W S G ++ SAS D TV LW+ + +E G+ + + V + Sbjct: 183 YGLSWNSNLSGHLL-SASDDHTVCLWDINAGPKE--GKIVDAKAIFTGHSAVVEDVAWHL 239 Query: 119 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 178 H + +D L ++D + + S H CLS+ P + Sbjct: 240 LHE-SLFGSVADDQKLMIWDTRSNTTSKP----------SHLVDAHTAEVNCLSFNP--Y 286 Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 S LA + ++ + ++ KL + HK I + W+P ++A+ D Sbjct: 287 SEFILATGSADKTVALWDLRNLKLKL-HTFESHKDEIFQVHWSPHN---ETILASSGTDR 342 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 R+ ++ +++ ++E++ ELL Sbjct: 343 RLNVWDLSKIGEEQSAEDAEDGP--------------------------------PELLF 370 Query: 299 EHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWK 332 H H ++ SWN ++ S +D +++W+ Sbjct: 371 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 405 Score = 80.8 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 43/198 (21%), Positives = 78/198 (39%), Gaps = 14/198 (7%) Query: 4 FDSGHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 62 +GH +V DV + + + + DQ + ++ +T + S AH + + + Sbjct: 224 IFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNT-TSKPSHLVDAHTAEVNCLS 282 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 + +P I+A+ S DKTV LW+ + KL T K ++ V ++P + Sbjct: 283 F-NPYSEFILATGSADKTVALWDLRNLKL--------KLHTFESHKDEIFQVHWSPHNE- 332 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKV-LSIPPANHLQSDFCLSWCPSRFSPE 181 LA G D L ++D + + +S + L H SW P Sbjct: 333 TILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNP-NEPWV 391 Query: 182 KLAVSALEQAIIYQRGKD 199 +VS I+Q ++ Sbjct: 392 ICSVSEDNIMQIWQMAEN 409 Score = 63.1 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 39/241 (16%), Positives = 83/241 (34%), Gaps = 20/241 (8%) Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 +G + ++ P + +A + ++D + + + H + Sbjct: 125 HEGEVNRARYMPQNP-HIIATKTPSSDVLVFDYTKHPAKPDPSGE---CNPDLRLRGHQK 180 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGK----LHVAAKLPGHKSLIRSISWAP 222 + LSW S S L+ S ++ K + A GH +++ ++W Sbjct: 181 EGYGLSWN-SNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWH- 238 Query: 223 SIGRWYQLIATGCKDGRIRIFKITEKLSPLAS---EESLTNSNMFDNSADVD-MDAQGRS 278 L + D ++ I+ + S + N + + + A G + Sbjct: 239 --LLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 296 Query: 279 DSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL-TGTILSSAGDDGKVRLWKATYSN 337 D L+ L + H E++ V W+ TIL+S+G D ++ +W + Sbjct: 297 DKTVALWDLRNLKLK---LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIG 353 Query: 338 E 338 E Sbjct: 354 E 354 Score = 28.1 bits (60), Expect = 5.5, Method: Composition-based stats. Identities = 7/42 (16%), Positives = 19/42 (45%), Gaps = 1/42 (2%) Query: 4 FDSGHDDLVHDVVYDFYGRHVA-TCSSDQHIKVFKLDKDTSN 44 GH + D ++ V + S D ++++++ ++ N Sbjct: 371 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYN 412 >5Z56-q nrPDB Length = 504 Score = 89.7 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 42/314 (13%), Positives = 105/314 (33%), Gaps = 46/314 (14%) Query: 20 YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDK 79 + T +D+++ VF + ++ + + H + ++ + + ++ SAS D Sbjct: 233 DTNKILTGGADKNVVVFDKSSE----QILATLKGHTKKVTSVVFHPSQ--DLVFSASPDA 286 Query: 80 TVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 139 T+++W + + + + ++ + G L +D D Sbjct: 287 TIRIWSV---------PNASCVQVVRAHESAVTGLSL--HATGDYLLSSSDDQYWAFSDI 335 Query: 140 LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE-QAIIYQRGK 198 L T + L+ C + P ++ Q I+ + Sbjct: 336 QTGRVLTKVTDETSGCSLT-----------CAQFHP---DGLIFGTGTMDSQIKIWDLKE 381 Query: 199 DGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASE-ES 257 + A PGH I SI+++ + +AT D ++++ + + + + ++ Sbjct: 382 RTNV---ANFPGHSGPITSIAFSEN----GYYLATAADDSSVKLWDLRKLKNFKTLQLDN 434 Query: 258 LTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT 317 A G +D + Q + +H+G V++ Sbjct: 435 NFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTE----ILHFTEHSGLTTGVAFGHHAK 488 Query: 318 ILSSAGDDGKVRLW 331 ++S G D ++ + Sbjct: 489 FIASTGMDRSLKFY 502 Score = 87.8 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 43/283 (15%), Positives = 87/283 (30%), Gaps = 84/283 (29%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA-- 64 GH V VV+ V + S D I+++ + N RAH+S++ + Sbjct: 262 GHTKKVTSVVFHPSQDLVFSASPDATIRIWSV----PNASCVQVVRAHESAVTGLSLHAT 317 Query: 65 -----------------------------------------SPEYGRIIASASYDKTVKL 83 P+ G I + + D +K+ Sbjct: 318 GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD-GLIFGTGTMDSQIKI 376 Query: 84 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 143 W+ + G + S+ F+ G LA +D ++L+D + Sbjct: 377 WDLKER---------TNVANFPGHSGPITSIAFS--ENGYYLATAADDSSVKLWDLRKLK 425 Query: 144 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE-QAIIYQRGKDGKL 202 + ++ L + +V S+ S LA+ + Q I + + Sbjct: 426 NFKTLQLDNNFEVKSLIFDQ---------------SGTYLALGGTDVQIYICK-----QW 465 Query: 203 HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 H L +++ G + IA+ D ++ + + Sbjct: 466 TEILHFTEHSGLTTGVAF----GHHAKFIASTGMDRSLKFYSL 504 Score = 55.4 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 36/249 (14%), Positives = 80/249 (32%), Gaps = 51/249 (20%) Query: 138 DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRG 197 + ++P +L + ++ + + L CPS + + L A + +++ + Sbjct: 197 ELVKPEELSKYR---QVASHVGLHSASIPGILALDLCPSDTN-KILTGGADKNVVVFDKS 252 Query: 198 KDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEES 257 + + A L GH + S+ + PS L+ + D IRI+ + Sbjct: 253 SE---QILATLKGHTKKVTSVVFHPS----QDLVFSASPDATIRIWSVPNASCVQVVRAH 305 Query: 258 LTNSNMFDNSADVDMDAQGRSD-------------------------------------- 279 + A D D Sbjct: 306 ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 365 Query: 280 --SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSN 337 + + ++ + ++ H+G + S++++ G L++A DD V+LW Sbjct: 366 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 425 Query: 338 EFKCMSVIT 346 FK + + Sbjct: 426 NFKTLQLDN 434 >3C9C-A nrPDB Length = 432 Score = 89.3 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 36/259 (13%), Positives = 91/259 (35%), Gaps = 39/259 (15%) Query: 7 GHDDLVHDVVYDFY-GRHVATCSSDQHIKVFKLDKDTSNWELSDS---WRAHDSSIVAID 62 GH + + ++ ++ + S D I ++ ++ + D+ + H + + + Sbjct: 181 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 240 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 W + S + D+ + +W+ + T++ + + F P Sbjct: 241 WHLLHE-SLFGSVADDQKLMIWDTR------NNNTSKPSHTVDAHTAEVNCLSFNPYSE- 292 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK 182 LA D + L+D ++K+ S +H F + W P + Sbjct: 293 FILATGSADKTVALWDLR----------NLKLKLHSF--ESHKDEIFQVQWSPHNETIL- 339 Query: 183 LAVSALEQAIIY-----------QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 + + ++ + +DG + GH + I SW P+ +I Sbjct: 340 ASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWII 396 Query: 232 ATGCKDGRIRIFKITEKLS 250 + +D ++++++ E + Sbjct: 397 CSVSEDNIMQVWQMAENVY 415 Score = 87.8 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 101/294 (34%), Gaps = 28/294 (9%) Query: 54 HDSSIVAIDWASPEYGRIIASA--SYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 111 H+ + + P+ +IA+ S D V + + P + E SG L L + Sbjct: 129 HEGEVNRARY-MPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLR-LRGHQKEG 186 Query: 112 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 171 Y + + P G L +D + L+D + H + Sbjct: 187 YGLSWNPNLNGYLL-SASDDHTICLWDINATPK------EHRVIDAKNIFTGHTAVVEDV 239 Query: 172 SWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 +W S +V+ ++ +I+ + + + H + + +S+ P ++ Sbjct: 240 AWHLLHESLFG-SVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP---YSEFIL 295 Query: 232 ATGCKDGRIRIFKITE-KLSPLASEESLTNSNMFDNSA-DVDMDAQGRSDSNTEEKAELQ 289 ATG D + ++ + KL + E S + + A +D + Sbjct: 296 ATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 355 Query: 290 SNLQ----------VELLSEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWK 332 + ELL H H ++ SWN I+ S +D +++W+ Sbjct: 356 IGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 409 Score = 82.0 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 80/198 (40%), Gaps = 14/198 (7%) Query: 4 FDSGHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 62 +GH +V DV + + + + DQ + ++ + + + S + AH + + + Sbjct: 228 IFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN-NTSKPSHTVDAHTAEVNCLS 286 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 + +P I+A+ S DKTV LW+ + KL + K ++ V+++P + Sbjct: 287 F-NPYSEFILATGSADKTVALWDLRNLKL--------KLHSFESHKDEIFQVQWSPHNE- 336 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKV-LSIPPANHLQSDFCLSWCPSRFSPE 181 LA G D L ++D + + +S + L H SW P Sbjct: 337 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP-NEPWI 395 Query: 182 KLAVSALEQAIIYQRGKD 199 +VS ++Q ++ Sbjct: 396 ICSVSEDNIMQVWQMAEN 413 Score = 68.5 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 37/251 (14%), Positives = 82/251 (32%), Gaps = 20/251 (7%) Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 +G + ++ P + +A + ++D + + + + H + Sbjct: 129 HEGEVNRARYMPQNA-CVIATKTPSSDVLVFDYTKHPSKPEPSGECQ---PDLRLRGHQK 184 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLH----VAAKLPGHKSLIRSISWAP 222 + LSW P + L+ S ++ K H GH +++ ++W Sbjct: 185 EGYGLSWNP-NLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH- 242 Query: 223 SIGRWYQLIATGCKDGRIRIFKITEK---LSPLASEESLTNSNMFDNSADVD-MDAQGRS 278 L + D ++ I+ + N + + + A G + Sbjct: 243 --LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 300 Query: 279 DSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL-TGTILSSAGDDGKVRLWKATYSN 337 D L+ L + H E++ V W+ TIL+S+G D ++ +W + Sbjct: 301 DKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIG 357 Query: 338 EFKCMSVITAQ 348 E + Sbjct: 358 EEQSTEDAEDG 368 Score = 28.4 bits (61), Expect = 4.7, Method: Composition-based stats. Identities = 7/42 (16%), Positives = 19/42 (45%), Gaps = 1/42 (2%) Query: 4 FDSGHDDLVHDVVYDFYGRHVA-TCSSDQHIKVFKLDKDTSN 44 GH + D ++ + + S D ++V+++ ++ N Sbjct: 375 IHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYN 416 >5Y1U-A nrPDB Length = 456 Score = 88.9 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 61/335 (18%), Positives = 115/335 (34%), Gaps = 64/335 (19%) Query: 8 HDDLVHDVVYDFYGRHVA---TCSSDQHIKVFKLDKDTSN----WELSDSWR--AHDSSI 58 H+ V+ Y + T SSD + VF K S E + R H Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSD--VLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 211 Query: 59 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 118 + W G ++ SAS D T+ LW+ +E G+ + + V + Sbjct: 212 YGLSWNPNLSGHLL-SASDDHTICLWDISAVPKE--GKVVDAKTIFTGHTAVVEDVSWHL 268 Query: 119 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 178 H + +D L ++D + + S H CLS+ P + Sbjct: 269 LHE-SLFGSVADDQKLMIWDTRSNNTSKP----------SHSVDAHTAEVNCLSFNP--Y 315 Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 S LA + ++ + ++ KL + + HK I + W+P ++A+ D Sbjct: 316 SEFILATGSADKTVALWDLRNLKLKLHS-FESHKDEIFQVQWSPHN---ETILASSGTDR 371 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 R+ ++ +++ + E++ ELL Sbjct: 372 RLNVWDLSKIGEEQSPEDAEDGP--------------------------------PELLF 399 Query: 299 EHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWK 332 H H ++ SWN ++ S +D +++W+ Sbjct: 400 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 434 Score = 87.8 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 37/259 (14%), Positives = 91/259 (35%), Gaps = 39/259 (15%) Query: 7 GHDDLVHDVVYDFYGR-HVATCSSDQHIKVFKLDKDTSNWELSDS---WRAHDSSIVAID 62 GH + + ++ H+ + S D I ++ + ++ D+ + H + + + Sbjct: 206 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 265 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 W + S + D+ + +W+ S +++ + + F P Sbjct: 266 WHLLHE-SLFGSVADDQKLMIWDTR------SNNTSKPSHSVDAHTAEVNCLSFNPYSE- 317 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK 182 LA D + L+D ++K+ S +H F + W P + Sbjct: 318 FILATGSADKTVALWDLR----------NLKLKLHSF--ESHKDEIFQVQWSPHNETIL- 364 Query: 183 LAVSALEQAIIY-----------QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 + + ++ + +DG + GH + I SW P+ +I Sbjct: 365 ASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPN---EPWVI 421 Query: 232 ATGCKDGRIRIFKITEKLS 250 + +D ++++++ E + Sbjct: 422 CSVSEDNIMQVWQMAENIY 440 Score = 82.0 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 41/199 (20%), Positives = 80/199 (40%), Gaps = 14/199 (7%) Query: 3 PFDSGHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 +GH +V DV + + + + DQ + ++ + + + S S AH + + + Sbjct: 252 TIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN-NTSKPSHSVDAHTAEVNCL 310 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 + +P I+A+ S DKTV LW+ + KL + K ++ V+++P + Sbjct: 311 SF-NPYSEFILATGSADKTVALWDLRNLKL--------KLHSFESHKDEIFQVQWSPHNE 361 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKV-LSIPPANHLQSDFCLSWCPSRFSP 180 LA G D L ++D + + +S + L H SW P Sbjct: 362 -TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP-NEPW 419 Query: 181 EKLAVSALEQAIIYQRGKD 199 +VS ++Q ++ Sbjct: 420 VICSVSEDNIMQVWQMAEN 438 Score = 63.9 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 38/241 (15%), Positives = 81/241 (33%), Gaps = 20/241 (8%) Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 +G + ++ P + +A + ++D + + + H + Sbjct: 154 HEGEVNRARYMPQNP-CIIATKTPSSDVLVFDYTKHPSKPDPSGE---CNPDLRLRGHQK 209 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGK----LHVAAKLPGHKSLIRSISWAP 222 + LSW P S L+ S ++ K + GH +++ +SW Sbjct: 210 EGYGLSWNP-NLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWH- 267 Query: 223 SIGRWYQLIATGCKDGRIRIFKITEK---LSPLASEESLTNSNMFDNSADVD-MDAQGRS 278 L + D ++ I+ + + N + + + A G + Sbjct: 268 --LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 325 Query: 279 DSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNL-TGTILSSAGDDGKVRLWKATYSN 337 D L+ L + H E++ V W+ TIL+S+G D ++ +W + Sbjct: 326 DKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIG 382 Query: 338 E 338 E Sbjct: 383 E 383 >5K1B-B nrPDB Length = 677 Score = 88.5 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 89/241 (36%), Gaps = 30/241 (12%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D V+D+V G+ + + SSD +KV+ + R H + A+ +A + Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWN----AHKGFCMSTLRTHKDYVKALAYAKDK 129 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 ++ASA D+ + LW+ + + +L+ +K S+YS+ LG + Sbjct: 130 --ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAM--NQLGTIIVS 185 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 + +LR++D + H + L R + L+ S+ Sbjct: 186 GSTEKVLRVWDPR-------------TCAKLMKLKGHTDNVKALLLN--RDGTQCLSGSS 230 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE 247 ++ G + A H + WA + + + +G +D +I + Sbjct: 231 DGTIRLWSLG---QQRCIATYRVHDEGV----WALQVNDAFTHVYSGGRDRKIYCTDLRN 283 Query: 248 K 248 Sbjct: 284 P 284 Score = 87.0 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 49/291 (16%), Positives = 103/291 (35%), Gaps = 29/291 (9%) Query: 10 DLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG 69 + V+ + D + T D I+++ +++ + ++ S H + I G Sbjct: 31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIA-SMEHHTDWVNDIVLCCN--G 87 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 129 + + SAS D TVK+W + C + TL K + ++ +A +A G Sbjct: 88 KTLISASSDTTVKVWNA--HKGFC-------MSTLRTHKDYVKALAYAKDKE--LVASAG 136 Query: 130 NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE 189 D + L+D + L + T V + + + S + L+ + + E Sbjct: 137 LDRQIFLWDVNTLTALTASNNT----VTTSSLSGNKDSIYSLA---MNQLGTIIVSGSTE 189 Query: 190 QAIIYQRGKDGKLHVA-AKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEK 248 + + R D + KL GH ++++ + R +G DG IR++ + ++ Sbjct: 190 KVL---RVWDPRTCAKLMKLKGHTDNVKAL----LLNRDGTQCLSGSSDGTIRLWSLGQQ 242 Query: 249 LSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSE 299 + G D +++V + E Sbjct: 243 RCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEE 293 Score = 68.9 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 37/246 (15%), Positives = 86/246 (34%), Gaps = 37/246 (15%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 + + +++ PA +L G D I+R++ + +H Sbjct: 30 RNGVNALQLDPALN--RLFTAGRDSIIRIWSV----------NQHKQDPYIASMEHHTDW 77 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW 227 + C + + ++ S+ ++ K + L HK ++++++A + Sbjct: 78 VNDIVLCCNGKT--LISASSDTTVKVW---NAHKGFCMSTLRTHKDYVKALAYA----KD 128 Query: 228 YQLIATGCKDGRIRIFKITEKLSPLASEESLTNS---------NMFDNSADVDMDAQGRS 278 +L+A+ D +I ++ + + AS ++T S + + G + Sbjct: 129 KELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGST 188 Query: 279 DSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNE 338 + L + H V ++ N GT S DG +RLW + Sbjct: 189 EKVLRVWDPRTCAK----LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS---LGQ 241 Query: 339 FKCMSV 344 +C++ Sbjct: 242 QRCIAT 247 Score = 60.8 bits (145), Expect = 8e-10, Method: Composition-based stats. Identities = 29/210 (13%), Positives = 70/210 (33%), Gaps = 18/210 (8%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SG+ D ++ + + G + + S+++ ++V+ +L + H ++ A+ Sbjct: 165 SGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL----KGHTDNVKAL--LL 218 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G S S D T++LW Q+ C + T +++++ + Sbjct: 219 NRDGTQCLSGSSDGTIRLWSL--GQQRC-------IATYRVHDEGVWALQV--NDAFTHV 267 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 G D + D P D+R + VL + + ++ + K + Sbjct: 268 YSGGRDRKIYCTDLRNP-DIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTL 326 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLI 215 + + + L + Sbjct: 327 KGIHNFRASGDYDNDCTNPITPLCTQPDQV 356 Score = 51.9 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 29/188 (15%), Positives = 60/188 (31%), Gaps = 30/188 (15%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D V ++ + G + SSD I+++ L ++R HD + A+ Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL----GQQRCIATYRVHDEGVWALQ--VN 261 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN-DSKGSLYSVKFAPAHLGLKL 125 + + S D+ + C+ R + L + K + ++ Sbjct: 262 DAFTHVYSGGRDRKI----------YCTDLRNPDIRVLICEEKAPVLKMELD-------- 303 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 D ++ A S + WTL + + + +D P P+++ Sbjct: 304 --RSADPPPAIWVATTKSTVNKWTLKG---IHNFRASGDYDNDCTNPITPLCTQPDQVIK 358 Query: 186 SALEQAII 193 Sbjct: 359 GGASIIQC 366 >5WJC-A nrPDB Length = 430 Score = 88.1 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 38/170 (22%), Positives = 72/170 (42%), Gaps = 13/170 (7%) Query: 8 HDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H D+V+DV + + +A+ S D +++ + E +AH +I A+ +P Sbjct: 234 HTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEE-EAPKVIQAHSKAINAVA-INP 291 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 ++A+AS DKTV LW+ + +L TL + +Y ++++P LA Sbjct: 292 FNDYLLATASADKTVALWDLR--------NPYQRLHTLEGHEDEVYGLEWSPHDE-PILA 342 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKV-LSIPPANHLQSDFCLSWCP 175 D + ++D + + ++ + L H SWCP Sbjct: 343 SSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCP 392 Score = 81.2 bits (198), Expect = 6e-16, Method: Composition-based stats. Identities = 51/331 (15%), Positives = 110/331 (33%), Gaps = 57/331 (17%) Query: 8 HDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKL----DKDTSNWELSDSWRAHDSSIVAID 62 HD V+ Y + AT + +F T + H + + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRW-NKLCTLNDSKGSLYSVKFAPAHL 121 W G +A+ + D+ + LW+ S + + + + + V+F P H Sbjct: 190 WNPNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHE 248 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 LA + +D L+++D + + + H ++ ++ P F+ Sbjct: 249 A-LLASVSDDCTLQIHDTRLNPEEEAPKVI----------QAHSKAINAVAINP--FNDY 295 Query: 182 KLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIR 241 LA ++ ++ + ++ + L GH+ + + W+P ++A+ D R+ Sbjct: 296 LLATASADKTVALWDLRNPYQRL-HTLEGHEDEVYGLEWSP---HDEPILASSSTDRRVC 351 Query: 242 IFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHD 301 I+ + + E++ ELL H Sbjct: 352 IWDLEKIGEEQTPEDAEDG--------------------------------SPELLFMHG 379 Query: 302 DHNGEVWSVSWNLTGT-ILSSAGDDGKVRLW 331 H + SW ++ S DD +++W Sbjct: 380 GHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 50.0 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 39/96 (40%), Gaps = 12/96 (12%) Query: 7 GHDDLVHDVVYDFYGR-HVATCSSDQHIKVFKL----------DKDTSNWELSDSWRAHD 55 GH+D V+ + + + +A+ S+D+ + ++ L D + + EL H Sbjct: 323 GHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHT 382 Query: 56 SSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQE 91 + I W E ++ S + D +++W Sbjct: 383 NRISEFSWCPNER-WVVGSLADDNILQIWSPSRVIW 417 >6Q8F-A nrPDB Length = 514 Score = 87.4 bits (214), Expect = 8e-18, Method: Composition-based stats. Identities = 50/242 (20%), Positives = 89/242 (36%), Gaps = 32/242 (13%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 F+ H V + + + + S DQ I++ L + +R H S + + Sbjct: 303 FERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKS----GKTLKEFRGHSSFVNEATF 358 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 123 + G I SAS D TVK+W ECS + L + + ++ SV P + Sbjct: 359 T--QDGHYIISASSDGTVKIWNMKTT--ECSN-TFKSLGSTAGTDITVNSVILLPKNPEH 413 Query: 124 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDF-CLSWCPSRFSPEK 182 + C ++ ++ + ++ V S DF C + P E Sbjct: 414 FVVCNRSNTVV------------IMNMQGQI-VRSFSSGKREGGDFVCCALSP---RGEW 457 Query: 183 LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 + + + GKL L H+ + I+ P LIAT +DG +++ Sbjct: 458 IYCVGEDFVLYCFSTVTGKL--ERTLTVHEKDVIGIAHHP----HQNLIATYSEDGLLKL 511 Query: 243 FK 244 +K Sbjct: 512 WK 513 >5WLC-LU nrPDB Length = 489 Score = 87.4 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 62/353 (17%), Positives = 106/353 (30%), Gaps = 66/353 (18%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 GH D V+ + ++ +AT S+D IK + + S++AH + + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE----FVSFKAHYGLVTGLCVTQ 120 Query: 66 PEY---------GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCT-----LNDSKGSL 111 P + + S S DKTVKLW + D N T + G Sbjct: 121 PRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGES 180 Query: 112 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 171 A G + L+D N L+ L Sbjct: 181 AFQGIDSHRENSTFATGGA--KIHLWDV-----------------------NRLKPVSDL 215 Query: 172 SWCPSRFSPEKL---------AVSALEQAIIYQ-RGKDGKLHVAAKLPGHKSLIRSISWA 221 SW + K + + ++Y R + + +I W Sbjct: 216 SWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRT-----NAICWN 270 Query: 222 PSIGRWYQLIATGCKDGRIRIFKITEKL-SPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 P T +D + + S ++ ++ D S D G D Sbjct: 271 PM---EAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDK 327 Query: 281 NTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 + ++N H V+ V +++ + S DDG VRLW++ Sbjct: 328 SIRIY---KTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRS 377 Score = 57.7 bits (137), Expect = 7e-09, Method: Composition-based stats. Identities = 46/297 (15%), Positives = 86/297 (28%), Gaps = 50/297 (16%) Query: 20 YGRHVATCSSDQHIKVFKLDKDTSNWE-------------LSDSWRAHDSSIVAIDWASP 66 + +CS D+ +K++ ++ D + + L ++ +S+ ID Sbjct: 132 SQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ESAFQGIDSH-- 188 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 A+ + LW+ + R + L+ ++ S+KF LA Sbjct: 189 RENSTFATGG--AKIHLWDVN---------RLKPVSDLSWGADNITSLKFNQNETD-ILA 236 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 G+D + LYD S + T + W P + Sbjct: 237 STGSDNSIVLYDLRTNSPTQKIVQTMRTNAIC--------------WNP--MEAFNFVTA 280 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + Y H S + + ++P+ I TG D IRI+K Sbjct: 281 NEDH-NAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPT----GDEIVTGSYDKSIRIYKTN 335 Query: 247 EKLSPLAS-EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDD 302 S + + + S D G D N + + Sbjct: 336 HGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTREKN 392 >5FVM-C nrPDB Length = 303 Score = 86.6 bits (212), Expect = 1e-17, Method: Composition-based stats. Identities = 41/263 (15%), Positives = 89/263 (33%), Gaps = 36/263 (13%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT--SNWELSDSWRAHDSSIVAIDWA 64 GH V + + R + + S D IKV+ + + N++ H++ + + Sbjct: 73 GHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-------HNAPVNEVA-I 124 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 P G +I S D +++W+ +Q C+ + + T L S+ A G Sbjct: 125 HPNQGELI-SCDQDGNIRIWDLGENQ--CTNQLTPEDNT------PLQSLSVASD--GSM 173 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 L N G ++ +D + ++ K + + S Sbjct: 174 LVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSH---------TKYITRVLLSADVKNLAT 224 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 SA A ++ + +L L GH+ + +++ + T C D +R++ Sbjct: 225 CSADHTARVWNIEDNYQL--ETTLDGHQRWVWDCAFSAD----SAYLVTACSDHYVRLWD 278 Query: 245 ITEKLSPLASEESLTNSNMFDNS 267 ++ + + Sbjct: 279 LSTSEIVRQYGGHHKGAVCVALN 301 Score = 68.5 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 51/314 (16%), Positives = 110/314 (35%), Gaps = 47/314 (14%) Query: 24 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 83 +A+ D I+ ++ S + + DS + ++ S + + +A+A + V+L Sbjct: 5 LASAGYDHTIRFWEALT----GVCSRTIQHADSQVNRLEITSDK--KYLAAAGH-LHVRL 57 Query: 84 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 143 ++ + + + KG++ S+ F + + DG ++++D PS Sbjct: 58 YDIRSNNPN-------PVSSFEGHKGNVTSIAFQQENR--WMVSSSEDGTIKVWDVRSPS 108 Query: 144 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLH 203 R++ + + ++I P E ++ I+ G++ Sbjct: 109 VQRNYKHNAPVNEVAIHPNQ----------------GELISCDQDGNIRIWDLGEN---Q 149 Query: 204 VAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASE------ES 257 +L + + S+ ++ G G ++++ E Sbjct: 150 CTNQLTPED---NTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSH 206 Query: 258 LTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT 317 SADV A +D ++ N Q+E D H VW +++ Sbjct: 207 TKYITRVLLSADVKNLATCSADHTARVWN-IEDNYQLETTL--DGHQRWVWDCAFSADSA 263 Query: 318 ILSSAGDDGKVRLW 331 L +A D VRLW Sbjct: 264 YLVTACSDHYVRLW 277 Score = 59.3 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 27/200 (13%), Positives = 64/200 (32%), Gaps = 57/200 (28%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELS------------------- 48 H+ V++V + +C D +I+++ L ++ +L+ Sbjct: 115 HNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSML 174 Query: 49 --------------------------DSWRAHDSSIVAIDWASPEYGRIIASASYDKTVK 82 +++H I + ++ +A+ S D T + Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN--LATCSADHTAR 232 Query: 83 LWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEP 142 +W + + + TL+ + ++ F+ L AC +D +RL+D Sbjct: 233 VWNIEDN--------YQLETTLDGHQRWVWDCAFSADSAYLVTAC--SDHYVRLWDLSTS 282 Query: 143 SDLRSWTLTSEMKVLSIPPA 162 +R + + V Sbjct: 283 EIVRQYGGHHKGAVCVALND 302 Score = 43.5 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 43/102 (42%), Gaps = 3/102 (2%) Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 ++A+ D IR ++ + + + + N + ++D A + + + Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLA---AAGHLHVRLYDI 60 Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + +S + H G V S+++ + S+ +DG +++W Sbjct: 61 RSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVW 102 >4LG8-A nrPDB Length = 354 Score = 85.8 bits (210), Expect = 2e-17, Method: Composition-based stats. Identities = 42/314 (13%), Positives = 105/314 (33%), Gaps = 46/314 (14%) Query: 20 YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDK 79 + T +D+++ VF + ++ + + H + ++ + + ++ SAS D Sbjct: 83 DTNKILTGGADKNVVVFDKSSE----QILATLKGHTKKVTSVVFHPSQ--DLVFSASPDA 136 Query: 80 TVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 139 T+++W + + + + ++ + G L +D D Sbjct: 137 TIRIWSV---------PNASCVQVVRAHESAVTGLSL--HATGDYLLSSSDDQYWAFSDI 185 Query: 140 LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE-QAIIYQRGK 198 L T + L+ C + P ++ Q I+ + Sbjct: 186 QTGRVLTKVTDETSGCSLT-----------CAQFHP---DGLIFGTGTMDSQIKIWDLKE 231 Query: 199 DGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASE-ES 257 + A PGH I SI+++ + +AT D ++++ + + + + ++ Sbjct: 232 RTNV---ANFPGHSGPITSIAFSEN----GYYLATAADDSSVKLWDLRKLKNFKTLQLDN 284 Query: 258 LTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT 317 A G +D + Q + +H+G V++ Sbjct: 285 NFEVKSLIFDQSGTYLALGGTD--VQIYICKQWTE----ILHFTEHSGLTTGVAFGHHAK 338 Query: 318 ILSSAGDDGKVRLW 331 ++S G D ++ + Sbjct: 339 FIASTGMDRSLKFY 352 Score = 84.3 bits (206), Expect = 7e-17, Method: Composition-based stats. Identities = 43/283 (15%), Positives = 87/283 (30%), Gaps = 84/283 (29%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA-- 64 GH V VV+ V + S D I+++ + N RAH+S++ + Sbjct: 112 GHTKKVTSVVFHPSQDLVFSASPDATIRIWSV----PNASCVQVVRAHESAVTGLSLHAT 167 Query: 65 -----------------------------------------SPEYGRIIASASYDKTVKL 83 P+ G I + + D +K+ Sbjct: 168 GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPD-GLIFGTGTMDSQIKI 226 Query: 84 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 143 W+ + G + S+ F+ G LA +D ++L+D + Sbjct: 227 WDLKER---------TNVANFPGHSGPITSIAFS--ENGYYLATAADDSSVKLWDLRKLK 275 Query: 144 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE-QAIIYQRGKDGKL 202 + ++ L + +V S+ S LA+ + Q I + + Sbjct: 276 NFKTLQLDNNFEVKSLIFDQ---------------SGTYLALGGTDVQIYICK-----QW 315 Query: 203 HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 H L +++ G + IA+ D ++ + + Sbjct: 316 TEILHFTEHSGLTTGVAF----GHHAKFIASTGMDRSLKFYSL 354 Score = 53.5 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 36/249 (14%), Positives = 80/249 (32%), Gaps = 51/249 (20%) Query: 138 DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRG 197 + ++P +L + ++ + + L CPS + + L A + +++ + Sbjct: 47 ELVKPEELSKYR---QVASHVGLHSASIPGILALDLCPSDTN-KILTGGADKNVVVFDKS 102 Query: 198 KDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEES 257 + + A L GH + S+ + PS L+ + D IRI+ + Sbjct: 103 SE---QILATLKGHTKKVTSVVFHPS----QDLVFSASPDATIRIWSVPNASCVQVVRAH 155 Query: 258 LTNSNMFDNSADVDMDAQGRSD-------------------------------------- 279 + A D D Sbjct: 156 ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 215 Query: 280 --SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSN 337 + + ++ + ++ H+G + S++++ G L++A DD V+LW Sbjct: 216 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLK 275 Query: 338 EFKCMSVIT 346 FK + + Sbjct: 276 NFKTLQLDN 284 >6EMK-B nrPDB Length = 303 Score = 85.5 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 44/268 (16%), Positives = 92/268 (34%), Gaps = 34/268 (12%) Query: 2 QPFDS--GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIV 59 P S GH V V + R + T S D IKV+ + + + +++ H++ + Sbjct: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS----IPRNYK-HNAPVN 120 Query: 60 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 119 + P G +I S D +++W+ +Q C+ + + T SL S+ A Sbjct: 121 EVV-IHPNQGELI-SCDRDGNIRIWDLGENQ--CTHQLTPEDDT------SLQSLSMASD 170 Query: 120 HLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFS 179 G LA G +++ +D ++ + S + S Sbjct: 171 --GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS---------TYITRILLSSDV 219 Query: 180 PEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 239 SA A ++ D + L GH+ + +++ + T D Sbjct: 220 KHLATCSADHTARVWSIDDD--FKLETTLDGHQRWVWDCAFSAD----SAYLVTASSDHY 273 Query: 240 IRIFKITEKLSPLASEESLTNSNMFDNS 267 +R++ ++ + + + Sbjct: 274 VRLWDLSTREIVRQYGGHHKGAVCVALN 301 Score = 73.9 bits (179), Expect = 9e-14, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 105/314 (33%), Gaps = 47/314 (14%) Query: 24 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 83 + + D I+ ++ S + + DS + ++ + + +++A+A + V+L Sbjct: 5 LVSAGYDHTIRFWEALT----GVCSRTIQHSDSQVNRLEITNDK--KLLATAGHQN-VRL 57 Query: 84 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 143 ++ + + +G++ SV F + + DG ++++D PS Sbjct: 58 YDIRTTNPN-------PVASFEGHRGNVTSVSFQQDNR--WMVTSSEDGTIKVWDVRSPS 108 Query: 144 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLH 203 R++ + + + I P E ++ I+ G++ Sbjct: 109 IPRNYKHNAPVNEVVIHPNQ----------------GELISCDRDGNIRIWDLGEN---Q 149 Query: 204 VAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL------ASEES 257 +L + S+ ++A G ++++ Sbjct: 150 CTHQLTPEDDTSLQ---SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAH 206 Query: 258 LTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT 317 T S+DV A +D + +L + D H VW +++ Sbjct: 207 STYITRILLSSDVKHLATCSADHTARVWSIDDD---FKLETTLDGHQRWVWDCAFSADSA 263 Query: 318 ILSSAGDDGKVRLW 331 L +A D VRLW Sbjct: 264 YLVTASSDHYVRLW 277 Score = 63.1 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 58/156 (37%), Gaps = 14/156 (8%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWEL--SDSWRAHDSSIVAIDWASP 66 D + + G +A ++ + V+++ T L +RAH + I I +S Sbjct: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + +A+ S D T ++W D D + TL+ + ++ F+ L Sbjct: 219 V--KHLATCSADHTARVWSIDDD--------FKLETTLDGHQRWVWDCAFSADSA--YLV 266 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPA 162 +D +RL+D +R + + V Sbjct: 267 TASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 Score = 42.7 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 40/102 (39%), Gaps = 3/102 (2%) Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 ++ + D IR ++ + + S + N + + D + A + + Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLAT---AGHQNVRLYDI 60 Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++ + H G V SVS+ + ++ +DG +++W Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 >1NR0-A nrPDB Length = 611 Score = 85.5 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 65/382 (17%), Positives = 121/382 (31%), Gaps = 59/382 (15%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFK-LDKDTSNWELSDSWR--AHDSSIVAIDWA 64 H VH V Y+ G A+ D I ++ +D + DS + AH S+ + W+ Sbjct: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWS 248 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECS------------GRRWNKLCTLNDSK---- 108 G IASAS DKT+K+W + E + G W K ++ S Sbjct: 249 PD--GTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFI 306 Query: 109 -------GSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP- 160 GS+ V++ + + DG L+ A + SW +++ + P Sbjct: 307 NFVNPELGSIDQVRYG-HNKAITALSSSADGK-TLFSADAEGHINSWDISTGISNRVFPD 364 Query: 161 ---------PANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPG- 210 F +SW + + L +A G Sbjct: 365 VHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGD 424 Query: 211 --HKSLIRSISW----------------APSIGRWYQLIATGCKDGRIRIFKITEKLSPL 252 + + I+ ++ Q +A G +D ++ ++K++ Sbjct: 425 IAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSE 484 Query: 253 ASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW 312 ++ S + +N ++ + H +V VSW Sbjct: 485 VKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSW 544 Query: 313 NLTGTILSSAGDDGKVRLWKAT 334 + L++ D V +W Sbjct: 545 SPDNVRLATGSLDNSVIVWNMN 566 Score = 73.5 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 41/336 (12%), Positives = 97/336 (28%), Gaps = 46/336 (13%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 + H G + A+ +++++ + T + + + I W Sbjct: 54 IYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPV--FSGPVKDISW 111 Query: 64 ASPEYGRIIASASYD--KTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 S + V L++ +G+ ++ SV F P+ Sbjct: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQA-----------RAMNSVDFKPSRP 160 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 ++ +D + +++ ++ H + + + P Sbjct: 161 -FRIISGSDDNTVAIFEGPPFKFKSTF-------------GEHTKFVHSVRYNP---DGS 203 Query: 182 KLAVSALEQAIIYQRGKDGKLHVAA-----KLPGHKSLIRSISWAPSIGRWYQLIATGCK 236 A + + I+ G DG K H + ++W+P + IA+ Sbjct: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTK----IASASA 259 Query: 237 DGRIRIFKITE-KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 295 D I+I+ + K+ + ++ ++ Sbjct: 260 DKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID-- 317 Query: 296 LLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 HN + ++S + G L SA +G + W Sbjct: 318 --QVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 Score = 47.7 bits (111), Expect = 7e-06, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 99/312 (31%), Gaps = 55/312 (17%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH+ + + G+ + + ++ HI + + SN D H + I I S Sbjct: 322 GHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDV---HATMITGIKTTSK 378 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCT----------------------- 103 + + S+D +K+ + S NKL + Sbjct: 379 GD---LFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIA 435 Query: 104 LNDSKG------SLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVL 157 + S S A ++ +A G D + +Y S T+ ++ Sbjct: 436 IYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEIT 495 Query: 158 SIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRS 217 S+ +N+ +A + I Y + +L H + + Sbjct: 496 SVAFSNN--------------GAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 Query: 218 ISWAPSIGRWYQLIATGCKDGRIRIFKITEKLS-PLASEESLTNSNMFDNSA-DVDMDAQ 275 +SW+P R +ATG D + ++ + + P+ + + S++ + Sbjct: 542 VSWSPDNVR----LATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVS 597 Query: 276 GRSDSNTEEKAE 287 DSN + Sbjct: 598 AGQDSNIKFWNV 609 >5L9T-R nrPDB Length = 493 Score = 85.1 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 90/255 (35%), Gaps = 37/255 (14%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V + + +++ S D+ + + D T + + H + + W++ Sbjct: 269 GHTARVGALAW--NAEQLSSGSRDR--MILQRDIRTPPLQSERRLQGHRQEVCGLKWSTD 324 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 +++AS D + +W + + + ++ ++ ++P GL + Sbjct: 325 H--QLLASGGNDNKLLVWNHS---------SLSPVQQYTEHLAAVKAIAWSPHQHGLLAS 373 Query: 127 CLG-NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 G D +R ++ L L+ S++ L+W Sbjct: 374 GGGTADRCIRFWNTLTGQPLQCIDTGSQVC--------------NLAWSKHANELVSTHG 419 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + Q ++++ L AKL GH + ++ +P + I TG D +R + + Sbjct: 420 YSQNQILVWKY---PSLTQVAKLTGHSYRVLYLAMSPD----GEAIVTGAGDETLRFWNV 472 Query: 246 TEKLSPLASEESLTN 260 K S+ N Sbjct: 473 FSKTRSTKESVSVLN 487 Score = 78.9 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 40/244 (16%), Positives = 86/244 (35%), Gaps = 28/244 (11%) Query: 91 EECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTL 150 + +LC L+ S+ SV ++ G +A + G ++++DA L Sbjct: 212 WSACTSQVTRLCDLSVEGDSVTSVGWS--ERGNLVAVGTHKGFVQIWDAAAGKKLSMLE- 268 Query: 151 TSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPG 210 H L+W + E+L+ + ++ I+ + + L +L G Sbjct: 269 ------------GHTARVGALAW-----NAEQLSSGSRDRMILQRDIRTPPLQSERRLQG 311 Query: 211 HKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADV 270 H+ + + W+ +QL+A+G D ++ ++ + E L S Sbjct: 312 HRQEVCGLKWSTD----HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQ 367 Query: 271 DMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSS--AGDDGKV 328 T ++ N + D +V +++W+ L S ++ Sbjct: 368 HGLLAS--GGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQI 425 Query: 329 RLWK 332 +WK Sbjct: 426 LVWK 429 Score = 54.6 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 45/129 (34%), Gaps = 8/129 (6%) Query: 206 AKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 265 L + S+ W+ L+A G G ++I+ E Sbjct: 223 CDLSVEGDSVTSVGWSE----RGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALA 278 Query: 266 NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDD 325 +A+ + G D ++ LQ E H EV + W+ +L+S G+D Sbjct: 279 WNAE--QLSSGSRDRMILQRDIRTPPLQSE--RRLQGHRQEVCGLKWSTDHQLLASGGND 334 Query: 326 GKVRLWKAT 334 K+ +W + Sbjct: 335 NKLLVWNHS 343 Score = 36.5 bits (82), Expect = 0.015, Method: Composition-based stats. Identities = 7/37 (18%), Positives = 16/37 (43%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT 42 +GH V + G + T + D+ ++ + + T Sbjct: 440 TGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476 Score = 28.8 bits (62), Expect = 3.4, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 19/44 (43%) Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKA 333 QV L + V SV W+ G +++ G V++W A Sbjct: 215 CTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDA 258 >5WYK-BB nrPDB Length = 943 Score = 85.1 bits (208), Expect = 5e-17, Method: Composition-based stats. Identities = 49/331 (14%), Positives = 109/331 (32%), Gaps = 35/331 (10%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 G V + + +AT S + +K++ + + ++ + + Sbjct: 389 GQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKT----HKCIRTFEC--GYALTCKFLP- 440 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G ++ + + ++L++ + +++S+ G +L Sbjct: 441 -GGLLVILGTRNGELQLFDLASSSLLDTIED--------AHDAAIWSLDLTSD--GKRLV 489 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHL---QSDFCLSWCPSRFSPEKL 183 D ++ +D + L T + VL + L C+ P L Sbjct: 490 TGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSP---DDRYL 546 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 A+S L+ + K ++ L GHK + SI I ++I T D I+I+ Sbjct: 547 AISLLDNTVKVFFLDSMKFYL--SLYGHKLPVLSI----DISFDSKMIITSSADKNIKIW 600 Query: 244 KITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDH 303 + + + D+ + + E + + H Sbjct: 601 GLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWD----GEKFECIQKLYAH 656 Query: 304 NGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 EVW+++ G + S+ D +R+W+ T Sbjct: 657 QSEVWALAVATDGGFVVSSSHDHSIRIWEET 687 Score = 79.7 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 37/260 (14%), Positives = 83/260 (31%), Gaps = 47/260 (18%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTS-----NWELSDSWRAHD 55 + + HD + + G+ + T S+D+ +K + + S + + H Sbjct: 465 LDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHH 524 Query: 56 -------SSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSK 108 I+ + + + +A + D TVK++ D +L K Sbjct: 525 DTTLELTDDILCVRVSPDDR--YLAISLLDNTVKVFFLD---------SMKFYLSLYGHK 573 Query: 109 GSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSD 168 + S+ + + D ++++ +S H S Sbjct: 574 LPVLSIDISFDSK--MIITSSADKNIKIWGLDFGDCHKSLFA-------------HQDSI 618 Query: 169 FCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWY 228 + + P + + + + + K KL H+S + WA ++ Sbjct: 619 MNVKFLPQSHN-----FFSCSKDAVVKYWDGEKFECIQKLYAHQSEV----WALAVATDG 669 Query: 229 QLIATGCKDGRIRIFKITEK 248 + + D IRI++ TE Sbjct: 670 GFVVSSSHDHSIRIWEETED 689 Score = 74.7 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 68/411 (16%), Positives = 121/411 (29%), Gaps = 101/411 (24%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI---VAID 62 +GH + + +D G + + S D +I V+ L + ++L R+H SI Sbjct: 118 NGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKL----RSHKDSITGFWC-- 171 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQ---------EECSGRRWNK---LCTLNDSKGS 110 + + S S D +KLW+ Q EC G + T DS+ Sbjct: 172 ----QGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDDLLITTGTDSQVK 227 Query: 111 LYSVKFAPAHLGLKLA-------------------CLGNDGILRLYDALEPSDLRSWTLT 151 ++ + +G KL +D Y + ++ + Sbjct: 228 IWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIR 287 Query: 152 SEMKV----------------------------------LSIPPANHLQSDFCLSWCPSR 177 E ++ L SW Sbjct: 288 KEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVS 347 Query: 178 FSPEKLA----VSALEQAIIYQRGKDGKLHVAAKLPGHK-------SLIRSISWAPSIGR 226 S +L + +E I +D A L H + +RSI + Sbjct: 348 SSKLELVLTTSSNTIEYYSIPYEKRDP--TSPAPLKTHTIELQGQRTDVRSIDISDDN-- 403 Query: 227 WYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA 286 +L+AT +G ++I+ I E + + G + + Sbjct: 404 --KLLATAS-NGSLKIWNIKTHKCIRTFECGYALT--CKFLPGGLLVILGTRNGELQLFD 458 Query: 287 ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSN 337 S+L L + D H+ +WS+ G L + D V+ W N Sbjct: 459 LASSSL---LDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVEN 506 Score = 56.6 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 33/218 (15%), Positives = 68/218 (31%), Gaps = 21/218 (9%) Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 G + D + ++D + + A + + + + Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYL----EAHKDTD 92 Query: 182 KLAVS-ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 LAV A ++ V GHK+ I + + + R + +G KD I Sbjct: 93 LLAVGYADGVIKVWDLMS---KTVLLNFNGHKAAITLLQFDGTGTR----LISGSKDSNI 145 Query: 241 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEH 300 ++ + ++ + F D D + + H Sbjct: 146 IVWDLVGEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQC----IETH 200 Query: 301 DDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNE 338 H GE W ++ + +L + G D +V++WK N+ Sbjct: 201 IAHTGECWGLA--VKDDLLITTGTDSQVKIWKLDIEND 236 Score = 48.5 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 54/184 (29%), Gaps = 35/184 (19%) Query: 20 YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDK 79 +A +D IKV+ L T + ++ H ++I + + G + S S D Sbjct: 90 DTDLLAVGYADGVIKVWDLMSKT----VLLNFNGHKAAITLLQF--DGTGTRLISGSKDS 143 Query: 80 TVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 139 + +W+ + L L K S+ L DG+++L+D Sbjct: 144 NIIVWDLVGEVG---------LYKLRSHKDSITGFWCQGEDW---LISTSKDGMIKLWDL 191 Query: 140 LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKD 199 T + I W + + Q I++ + Sbjct: 192 K----------THQCIETHIAHTGEC-------WGLAVKDDLLITTGTDSQVKIWKLDIE 234 Query: 200 GKLH 203 Sbjct: 235 NDKM 238 Score = 39.2 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 42/130 (32%), Gaps = 18/130 (13%) Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADV--- 270 I + S + QLI + +D + I+ I + L A Sbjct: 25 WIPASSGNSNGSGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAEC 82 Query: 271 ---------DMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSS 321 D+ A G +D + + +L + H + + ++ TGT L S Sbjct: 83 TYLEAHKDTDLLAVGYADGVIKVWDLMSKT----VLLNFNGHKAAITLLQFDGTGTRLIS 138 Query: 322 AGDDGKVRLW 331 D + +W Sbjct: 139 GSKDSNIIVW 148 >4J0W-A nrPDB Length = 343 Score = 83.5 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 40/247 (16%), Positives = 85/247 (34%), Gaps = 40/247 (16%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V + G+++A+ + I +++ + ++ H ++ + + Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY----TFTGHRDAVSGLAF--- 117 Query: 67 EYGRI-IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 G + S S+D++VK+W + + TL + ++ + Sbjct: 118 RRGTHQLYSTSHDRSVKVWNVAENSY---------VETLFGHQDAV--AALDALSRECCV 166 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS----DFCLSWCPSRFSPE 181 G DG +R++ E S L + + + + H+ S W S+ P Sbjct: 167 TAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPL 226 Query: 182 KLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIR 241 L A G G+ + I S++ L+ATG +R Sbjct: 227 ALQREA--------HGLRGEPGLEQPF-----WISSVA----ALLNTDLVATGSHSSCVR 269 Query: 242 IFKITEK 248 +++ E Sbjct: 270 LWQCGEG 276 Score = 67.7 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 50/356 (14%), Positives = 116/356 (32%), Gaps = 58/356 (16%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWR-------AHDSSIV 59 GH + +V + + + D I + ++ + + + H S ++ Sbjct: 12 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 71 Query: 60 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 119 + A G+ +AS K + +WE Q L T + ++ + F Sbjct: 72 CM--AISSDGKYLASGDRSKLILIWEAQSCQ---------HLYTFTGHRDAVSGLAF--R 118 Query: 120 HLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFS 179 +L +D +++++ E S + + L ++ A + Sbjct: 119 RGTHQLYSTSHDRSVKVWNVAENSYVET--LFGHQDAVAALDALSRECCVT--------- 167 Query: 180 PEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 239 A +++ ++ +L V G I I + + +G DG Sbjct: 168 ----AGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI--------NEEHMVSGADDGS 214 Query: 240 IRIF--KITEKLSPLASEESLTN---------SNMFDNSADVDMDAQGRSDSNTEEKAEL 288 + ++ L+ L + + D+ A G S Sbjct: 215 VALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCG 274 Query: 289 QSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSA-GDDGKV-RLWKATYSNEFKCM 342 + Q++LL + G + S+ ++ +G L + G + ++ R W+ + C+ Sbjct: 275 EGFRQLDLLCDIP-LVGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCI 329 Score = 63.9 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 29/194 (14%), Positives = 74/194 (38%), Gaps = 25/194 (12%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +GH D V + + + + S D+ +KV+ + +++ ++ H ++ A+D A Sbjct: 106 TGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSY----VETLFGHQDAVAALD-AL 160 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + A D TV++W+ + + +GS+ + + Sbjct: 161 SRECCVTA-GGRDGTVRVWKIPEESQ----------LVFYGHQGSIDCIHLINEEH---M 206 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 +DG + L+ + L + + + L+ F +S + + + +A Sbjct: 207 VSGADDGSVALWGLSKKRPLAL-----QREAHGLRGEPGLEQPFWISSVAALLNTDLVAT 261 Query: 186 SALEQAI-IYQRGK 198 + + ++Q G+ Sbjct: 262 GSHSSCVRLWQCGE 275 Score = 57.3 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 97/293 (33%), Gaps = 35/293 (11%) Query: 48 SDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN-- 105 R H SI + + I SA+ D ++ W + ++ R K Sbjct: 7 IRVLRGHQLSITCLVVTPDD--SAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPP 64 Query: 106 DSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHL 165 + + + G LA ++ +++A L ++T H Sbjct: 65 GHSSHVLCMAISSD--GKYLASGDRSKLILIWEAQSCQHLYTFT-------------GHR 109 Query: 166 QSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIG 225 + L++ R + + + S ++ ++ +V L GH+ + ++ Sbjct: 110 DAVSGLAFR--RGTHQLYSTSHDRSVKVWNVAENS--YVE-TLFGHQDAVAAL----DAL 160 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSN---- 281 + G +DG +R++KI E+ L + + + M + S Sbjct: 161 SRECCVTAGGRDGTVRVWKIPEESQ-LVFYGHQGSIDCIHLINEEHMVSGADDGSVALWG 219 Query: 282 TEEKAELQSNLQVELLSEHDDHNGEVW--SVSWNLTGTILSSAGDDGKVRLWK 332 +K L + L W SV+ L ++++ VRLW+ Sbjct: 220 LSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 272 >4XYI-A nrPDB Length = 430 Score = 82.8 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 59/138 (42%), Gaps = 11/138 (7%) Query: 7 GHDDLVHDVVYDFYGRH-VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 H+ V+ V ++ + + +AT S+D + ++ L + + H+ + + W+ Sbjct: 279 AHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLH---TLEGHEDEVYNVQWSP 335 Query: 66 PEYGRIIASASYDKTVKLWE-----EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + I+ ++S D+ V +W+ E+ E+ + + + + P + Sbjct: 336 HDE-PILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNN 394 Query: 121 LGLKLACLGNDGILRLYD 138 LA L +D IL+++ Sbjct: 395 -KWVLASLADDNILQIWS 411 Score = 82.0 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 73/173 (42%), Gaps = 13/173 (7%) Query: 8 HDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H +V+D+ + + + + S D +++ +S+ S +AH+ + + + +P Sbjct: 234 HTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSA-SQCVKAHEQPVNGVAF-NP 291 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 ++A+AS D TV LW+ R +L TL + +Y+V+++P L Sbjct: 292 FNDYLLATASADHTVALWDLR--------RLNQRLHTLEGHEDEVYNVQWSPHDE-PILV 342 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKV-LSIPPANHLQSDFCLSWCPSRF 178 D + ++D + + ++ + + L H LSW P+ Sbjct: 343 TSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNK 395 Score = 69.3 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 117/336 (34%), Gaps = 61/336 (18%) Query: 8 HDDLVHDVVYDFYG-RHVATCSSDQHIKVFKL--DKDTSNWELS--DSWRAHDSSIVAID 62 H+ V+ + +AT + + +F L ++ + R H S + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEEC-SGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 W + G +A+ + D ++ +W+ + + + ++F H Sbjct: 190 WNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 L + +D L+++D PS + H Q +++ P F+ Sbjct: 249 A-LLTSVSDDCTLQIHDTRLPSSSSASQCV----------KAHEQPVNGVAFNP--FNDY 295 Query: 182 KLAVSALEQAIIYQRGK--DGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 239 LA ++ + + + + +LH L GH+ + ++ W+P ++ T D R Sbjct: 296 LLATASADHTVALWDLRRLNQRLH---TLEGHEDEVYNVQWSP---HDEPILVTSSTDRR 349 Query: 240 IRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSE 299 + ++ +++ E+S + EL+ Sbjct: 350 VCVWDLSKIGEEQTVEDSEDGA--------------------------------PELMFM 377 Query: 300 HDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWKAT 334 H H V +SWN +L+S DD +++W + Sbjct: 378 HGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPS 413 Score = 54.3 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 39/96 (40%), Gaps = 12/96 (12%) Query: 7 GHDDLVHDVVYDFYGR-HVATCSSDQHIKVFKL----------DKDTSNWELSDSWRAHD 55 GH+D V++V + + + T S+D+ + V+ L D + EL H Sbjct: 323 GHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHT 382 Query: 56 SSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQE 91 + + + W ++AS + D +++W Sbjct: 383 NRVSDLSWNPNNK-WVLASLADDNILQIWSPSKVIW 417 Score = 53.9 bits (127), Expect = 9e-08, Method: Composition-based stats. Identities = 36/292 (12%), Positives = 88/292 (30%), Gaps = 56/292 (19%) Query: 54 HDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS 113 H+ + + P+ IIA+ + +++ + +E+ + ++ C L + Sbjct: 130 HEGDVNKARF-MPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQAC-LRHHTSEGFG 187 Query: 114 VKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 173 + + G LA D + ++D S + ++ +S+ H L + Sbjct: 188 LGWNFIQEGT-LATGTEDTSICVWDI--KGKSLSLEKSIDVAPVSVYH-RHTAVVNDLQF 243 Query: 174 CPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIAT 233 + I+ + + H+ + +++ P L+AT Sbjct: 244 HLQHEALLTSVSDDC-TLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFN---DYLLAT 299 Query: 234 GCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ 293 D + ++ + Sbjct: 300 ASADHTVALWDLRRLNQ------------------------------------------- 316 Query: 294 VELLSEHDDHNGEVWSVSWNL-TGTILSSAGDDGKVRLWKATYSNEFKCMSV 344 L + H EV++V W+ IL ++ D +V +W + E + + Sbjct: 317 --RLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVED 366 >3JB9-g nrPDB Length = 558 Score = 81.6 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 44/340 (12%), Positives = 104/340 (30%), Gaps = 42/340 (12%) Query: 13 HDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNW---ELSDSWRAHDSSIVAIDWASPEYG 69 D ++D+ R +D I + + + + + + +W+ H I + + P G Sbjct: 221 KDRLFDYQNRSYMHVPNDVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFF-PISG 279 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 129 ++ S S D +K+WE D+ T + + F+ G Sbjct: 280 HLLLSGSMDNQIKIWEVYHDRSLLR--------TFQGHARPIRDLSFSQD--GRSFLSTS 329 Query: 130 NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE 189 D ++L+D L + + P + + Sbjct: 330 FDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDK--------------PNEFLAGTAD 375 Query: 190 QAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKL 249 + I+ + + H I SI++ + R T D +R ++ + Sbjct: 376 KRILQFDIRSPD--IVQAYDHHLGGINSITFLENGKR----FVTTSDDSSMRFWEYGTPV 429 Query: 250 SPL-ASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ-VELLSEHDDHNGEV 307 ++ ++ + + A D+ + + Q + + + +G Sbjct: 430 PIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYS 489 Query: 308 WSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 347 V ++ G + S G W ++K ++ Sbjct: 490 LEVGFSPDGRFVFSGDSSGNACFW------DWKTCKLMAK 523 Score = 68.1 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 40/271 (14%), Positives = 92/271 (33%), Gaps = 53/271 (19%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWA-- 64 GH + D+ + GR + S D+ IK++ DT + + + + D + + Sbjct: 308 GHARPIRDLSFSQDGRSFLSTSFDKTIKLW----DTELGKCLNCFNS-DRLTNCVKFQVD 362 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + +A + DK + ++ + G + S+ F G + Sbjct: 363 PDKPNEFLA-GTADKRILQFDIRSPDIVQAYDH---------HLGGINSITF--LENGKR 410 Query: 125 LACLGNDGILRLYDALEPSDLRSWT--LTSEMKVLSIPPANHLQSDFCL--------SWC 174 +D +R ++ P ++ M +++ P + L ++ Sbjct: 411 FVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYE 470 Query: 175 PSRFSPEKLAVS------------ALEQAIIYQRGKDGKL--------HVAAKLPGHKSL 214 R + +K+ + + ++ G + AKLP H Sbjct: 471 KYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGP 530 Query: 215 IRSISWAPSIGRWYQLIATGC-KDGRIRIFK 244 ++S+++ P + +AT DG I+ + Sbjct: 531 VQSMAFHP---QETSKVATSSIVDGSIKYWD 558 >5OQL-L nrPDB Length = 557 Score = 81.2 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 68/227 (29%), Gaps = 19/227 (8%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 D H GR + ++VF + + + +W H + W+ E Sbjct: 99 DSEAHCGEIRPDGRVLVAGEDTGRMQVFDV-GQGTRAVILKTWHIHKQPVWVTKWSPTEL 157 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL-KLAC 127 ++ S S DKTV+LW+ + + F P L Sbjct: 158 TTLM-SCSDDKTVRLWDLPSND---------PTRLFTGHTDYVRCGAFMPGSANSNLLVS 207 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF------SPE 181 D +R++DA P T + + P + S P Sbjct: 208 GSYDETVRVWDARAPGG-AVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPL 266 Query: 182 KLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWY 228 +L + + G+ V+ L GH + + SW G Y Sbjct: 267 RLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKY 313 Score = 67.7 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 22/166 (13%), Positives = 54/166 (32%), Gaps = 40/166 (24%) Query: 8 HDDLVHDVVYDFYG-RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS- 65 H V + + +CS D+ ++++ L + + + H + + Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDP----TRLFTGHTDYVRCGAFMPG 198 Query: 66 PEYGRIIASASYDKTVKLWEED---------------------PDQEECSGRRWNKLCTL 104 ++ S SYD+TV++W+ P N + L Sbjct: 199 SANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVL 258 Query: 105 -----------NDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDA 139 + + ++ S+ A G ++ DG +++++ Sbjct: 259 DLVAAKPLRLITNHQKTVTSLSLA--SQGRRVVSGSLDGHVKVFET 302 Score = 62.0 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 39/258 (15%), Positives = 77/258 (29%), Gaps = 27/258 (10%) Query: 78 DKTVKLWEEDPDQEEC----SGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGI 133 D V + ED + + G R L T + K ++ K++P L ++C +D Sbjct: 110 DGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSC-SDDKT 168 Query: 134 LRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAII 193 +RL+D R +T H C ++ P + L + ++ + Sbjct: 169 VRLWDLPSNDPTRLFT-------------GHTDYVRCGAFMPGSANSNLLVSGSYDETV- 214 Query: 194 YQRGKDGKLHVAAKLP-GHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL 252 R D + A + H I + PS L+A I + + Sbjct: 215 --RVWDARAPGGAVMTFKHADPIEDVLPLPS---GTTLLAASG--NAISVLDLVAAKPLR 267 Query: 253 ASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW 312 ++ G D + + N+ + V + Sbjct: 268 LITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGA 327 Query: 313 NLTGTILSSAGDDGKVRL 330 + L+ G + + Sbjct: 328 SHDDRHLAVGMQSGVLSI 345 Score = 46.5 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 45/160 (28%), Gaps = 14/160 (8%) Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW---YQLIATGCKDGRIR 241 S QR + I IS+ S+G + K + Sbjct: 14 PSGPSPITAEQRYWRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLF 73 Query: 242 IFKITE--KLSPLASEESLTNSNMFD-------NSADVDMDAQGRSDSNTEEKAELQSNL 292 ++ + E L FD D + G + Q Sbjct: 74 AVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTR 133 Query: 293 QVELLSEHDDHNGEVWSVSWNLTG-TILSSAGDDGKVRLW 331 V L + H H VW W+ T T L S DD VRLW Sbjct: 134 AVILKTWHI-HKQPVWVTKWSPTELTTLMSCSDDKTVRLW 172 Score = 35.8 bits (80), Expect = 0.027, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 16/33 (48%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKL 38 + H V + GR V + S D H+KVF+ Sbjct: 270 TNHQKTVTSLSLASQGRRVVSGSLDGHVKVFET 302 >5NZU-C nrPDB Length = 905 Score = 80.8 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 41/324 (12%), Positives = 101/324 (31%), Gaps = 41/324 (12%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 + D V V + + + V+ + T L ++ D + A + + Sbjct: 12 TARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQT----LVKTFEVCDLPVRAAKFVA 67 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + + + + D ++++ + ++ + + P + Sbjct: 68 RK--NWVVTGADDMQIRVFNYNT---------LERVHMFEAHSDYIRCIAVHPTQ--PFI 114 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 +D +++L+D + W+ + H + P + A Sbjct: 115 LTSSDDMLIKLWDWDKK-----WSCSQVF-------EGHTHYVMQIVINP--KDNNQFAS 160 Query: 186 SALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 ++L++ I ++Q G L GH+ + I + G + +G D ++I+ Sbjct: 161 ASLDRTIKVWQLGSSSPNF---TLEGHEKGVNCIDY--YSGGDKPYLISGADDRLVKIWD 215 Query: 245 ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHN 304 K E N + ++ + G D L+ L + Sbjct: 216 YQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGME--- 272 Query: 305 GEVWSVSWNLTGTILSSAGDDGKV 328 VW V+ ++ D+G + Sbjct: 273 -RVWCVASLRGSNNVALGYDEGSI 295 Score = 80.8 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 37/290 (12%), Positives = 86/290 (29%), Gaps = 39/290 (13%) Query: 47 LSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLND 106 + A + ++D E + ++ Y+ +V +W + + + Sbjct: 7 IKRKLTARSDRVKSVDLHPTE--PWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAK 64 Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 V +D +R+++ + + H Sbjct: 65 FVARKNWV-----------VTGADDMQIRVFNYNTLERVHMFEA-------------HSD 100 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGR 226 C++ P + +++ + +I D K + GH + I P + Sbjct: 101 YIRCIAVHP----TQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINP---K 153 Query: 227 WYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSA--DVDMDAQGRSDSNTEE 284 A+ D I+++++ E N D + D G D + Sbjct: 154 DNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKI 213 Query: 285 KAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 + + H V S++ I+ + +DG VR+W ++ Sbjct: 214 WDYQNKTC----VQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSS 259 >5OQL-d nrPDB Length = 446 Score = 80.1 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 56/335 (16%), Positives = 110/335 (32%), Gaps = 43/335 (12%) Query: 4 FDSGHDDLVHDVVYDFYG-RHVATCSSDQHIKVFKLDK-DTSNWELSDSWRAHDSSIVAI 61 +GH V+ + D +A+ S D +KV+ L D W ++ AH++ + + Sbjct: 61 LGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVA----AHNNIVKGL 116 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSG-RRWNKLCTLNDSKGSLYSVKFAPAH 120 + + + + S + D +KLW+ + W + G S+ F Sbjct: 117 TFTNDKK---LLSCATDG-IKLWDPYASPSNTTPIATWQE-------GGPYTSLSF--HR 163 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 A G +R++D + + + P +D C + + Sbjct: 164 SANTFAASSGQGCIRIWDLEHSTAGQ---------AIQWPSFVDTITDVCFN----QVET 210 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 + A +++II + + L H + I + P +A +D I Sbjct: 211 SVIGSVATDRSIILFDLRTNMPVIKTVL--HFAC-NRIVFNPM---EAMNLAVASEDHNI 264 Query: 241 RIFKITE-KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSE 299 IF + + + + S + G D + + Sbjct: 265 YIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLW---RRDAGHSRDVY 321 Query: 300 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 H V+ W + + + DDG VRLW+A Sbjct: 322 HTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRAN 356 Score = 55.8 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 18/97 (18%), Positives = 32/97 (32%), Gaps = 23/97 (23%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID- 62 GH V DV + G + + S D+ I++++ D H + Sbjct: 278 IQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDA------------GHSRDVYHTKR 325 Query: 63 --------WASPEYGRIIASASYDKTVKLWEEDPDQE 91 W + I + S D V+LW + + Sbjct: 326 MQRVFRTMWTMD--SKYILTGSDDGNVRLWRANASER 360 Score = 31.9 bits (70), Expect = 0.42, Method: Composition-based stats. Identities = 7/50 (14%), Positives = 21/50 (42%), Gaps = 9/50 (18%) Query: 5 DSGHDDLVHDVV---------YDFYGRHVATCSSDQHIKVFKLDKDTSNW 45 D+GH V+ + +++ T S D ++++++ + + Sbjct: 313 DAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERSG 362 >6ELZ-p nrPDB Length = 460 Score = 79.7 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 45/338 (13%), Positives = 96/338 (28%), Gaps = 52/338 (15%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 +D V + +H+ + S D ++ + L + + H I A+ + S Sbjct: 103 EDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQ-----YSGHSGPIRAVKYISNTR 157 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSG--------------RRWNKLCTLNDSKGSLYSV 114 + SA D+T++LW+ D + + L L K + S+ Sbjct: 158 ---LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSI 214 Query: 115 KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 + ++ D + + + +T + I N+ S Sbjct: 215 DVS---DNSRILSASYDNSIGFWSTIYK------EMTVVDPLEDINNPNNKISTAARKRR 265 Query: 175 PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATG 234 + A L H + + + + + + Sbjct: 266 KLTMKDGTIRRRAPLSL----------------LESHTAPVEQVIFDSTDNTVGY---SV 306 Query: 235 CKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQV 294 +D I+ + + S + + +++ A G S + Sbjct: 307 SQDHTIKTWDLVTARCIDTRTTS-YSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSK 365 Query: 295 ELLSEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLW 331 + H V S+ IL S DG V++W Sbjct: 366 VTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVW 403 Score = 68.9 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 49/330 (14%), Positives = 104/330 (31%), Gaps = 73/330 (22%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT-------------------SNWE 46 SGH + V Y + + +D+ ++++K D + + Sbjct: 141 SGHSGPIRAVKY-ISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGK 199 Query: 47 LSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE------------EDPDQEE-- 92 H + +V+ID + I SASYD ++ W ED + Sbjct: 200 TLAILEGHKAPVVSIDVSDNSR---ILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNK 256 Query: 93 ---------------CSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLY 137 + RR L L + V F + D ++ + Sbjct: 257 ISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTD-NTVGYSVSQDHTIKTW 315 Query: 138 DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRG 197 D + + + T + + ++ +L + + + P A S + Q Sbjct: 316 DLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQ------- 368 Query: 198 KDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT--EKLSPLASE 255 +L GHK+ + S+ P ++ +G DG ++++ + + + E Sbjct: 369 --------QQLIGHKNFVSSLDTCPEN---EYILCSGSHDGTVKVWDVRSTSPMYTITRE 417 Query: 256 ESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 + + D V + S ++K Sbjct: 418 DKSVQKGVNDKVFAVKWAEKVGIISAGQDK 447 Score = 48.1 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 47/115 (40%), Gaps = 5/115 (4%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTV 81 +A SS +HI + S+ H + + ++D PE I+ S S+D TV Sbjct: 342 NLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLD-TCPENEYILCSGSHDGTV 400 Query: 82 KLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRL 136 K+W+ + R +K +++VK+A + G D +++ Sbjct: 401 KVWDVRSTSPMYTITREDK-SVQKGVNDKVFAVKWAEKVG---IISAGQDKKIQI 451 Score = 42.3 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 38/253 (15%), Positives = 77/253 (30%), Gaps = 10/253 (3%) Query: 68 YGRIIASASYDK-TVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G ++ ++ +D T K + R LN + + Sbjct: 60 EGELLRTSLHDYLTKKGLSSEASLNVEYTRAILPPSYLNSFSNEDWVSSLDVGDGSKHII 119 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHL---QSDFCLSWCPSRFSPEKL 183 DGI+R +D + + ++ + L +D L ++ KL Sbjct: 120 SGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKYISNTRLVSAGNDRTLRLWKTKNDDLKL 179 Query: 184 AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 Q A L GHK+ + SI + + I + D I + Sbjct: 180 TSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSDN-----SRILSASYDNSIGFW 234 Query: 244 -KITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDD 302 I ++++ + E + N N ++A D +A L E Sbjct: 235 STIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVI 294 Query: 303 HNGEVWSVSWNLT 315 + +V ++++ Sbjct: 295 FDSTDNTVGYSVS 307 Score = 32.3 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 39/85 (45%), Gaps = 2/85 (2%) Query: 254 SEESLTNSNMFDNSADVDM-DAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW 312 L + + D + +D+ D S + + +L + ++ H+G + +V + Sbjct: 93 PPSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKY 152 Query: 313 NLTGTILSSAGDDGKVRLWKATYSN 337 ++ T L SAG+D +RLWK + Sbjct: 153 -ISNTRLVSAGNDRTLRLWKTKNDD 176 >2AQ5-A nrPDB Length = 402 Score = 78.9 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 24/157 (15%), Positives = 55/157 (35%), Gaps = 14/157 (8%) Query: 2 QPFDSGHDDLVHDVVYDFYGRH-VATCSSDQHIKVFKLDKDTSNWEL---SDSWRAHDSS 57 P GH V D+ + + + +A+ S D + V+++ L + H Sbjct: 74 VPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKR 133 Query: 58 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA 117 + + W P ++ SA D + +W+ + + ++YSV ++ Sbjct: 134 VGIVAW-HPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP-------DVHPDTIYSVDWS 185 Query: 118 PAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEM 154 G + D +R+ + + + + E Sbjct: 186 --RDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEG 220 Score = 67.3 bits (162), Expect = 8e-12, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 82/250 (32%), Gaps = 17/250 (6%) Query: 94 SGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSE 153 +GR + + + + + P + +A D + +++ + L Sbjct: 67 TGRVDKNVPLVCGHTAPVLDIAWCPHNDN-VIASGSEDCTVMVWEIPDGG------LVLP 119 Query: 154 MKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKS 213 ++ I H + ++W P+ + L + + I+ G + H Sbjct: 120 LREPVITLEGHTKRVGIVAWHPTAQN--VLLSAGCDNVILVWDVGTGAAVLTLGPDVHPD 177 Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKL---SPLASEESLTNSNMFDNSADV 270 I S+ W+ R LI T C+D R+R+ + + E + S Sbjct: 178 TIYSVDWS----RDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGK 233 Query: 271 DMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG-DDGKVR 329 + S + +L+ L + D + V ++ I+ G D +R Sbjct: 234 ILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIR 293 Query: 330 LWKATYSNEF 339 ++ T F Sbjct: 294 YFEITSEAPF 303 Score = 46.5 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 57/167 (34%), Gaps = 13/167 (7%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D ++ V + G + T D+ ++V + K T E + A+ + + Sbjct: 175 HPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEG-TRPVHAVFVSEGK 233 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 S ++ V LW+ +E S + D+ + F P + C Sbjct: 234 ILTTGFSRMSERQVALWDTKHLEEPLSLQE-------LDTSSGVLLPFFDPD-TNIVYLC 285 Query: 128 LGNDGILRLYDALEPSD----LRSWTLTSEMKVLSIPPANHLQSDFC 170 D +R ++ + L ++ + + P L+ + C Sbjct: 286 GKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKC 332 >6BX3-A nrPDB Length = 314 Score = 75.4 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 107/288 (37%), Gaps = 33/288 (11%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 Q + H ++ + G+ +AT S D +++ L + L ++ H + ++++ Sbjct: 47 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLS-----YGLLHTFIGHTAPVISL 101 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 + G ++ ++S D+++K+W+ + T++ ++ SV P + Sbjct: 102 TF--NRKGNLLFTSSMDESIKIWDTLNGSL---------MKTISAHSEAVVSVDV-PMND 149 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 L+ DG++R++DA L++ T + K + +S + Sbjct: 150 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKREN--------GVVPISQVKFSENAR 201 Query: 182 KLAVSALEQAI-IYQ--RGKDGKLHVAAKLPG---HKSLIRSISWAPSIGRWYQLIATGC 235 L V +L+ + I+ G + L H S P G L+ +G Sbjct: 202 YLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDF-LNPEDG-STPLVISGY 259 Query: 236 KDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTE 283 ++G I + K + SL + + S + N + Sbjct: 260 ENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGD 307 >5WLC-LJ nrPDB Length = 513 Score = 74.3 bits (180), Expect = 8e-14, Method: Composition-based stats. Identities = 53/353 (15%), Positives = 114/353 (32%), Gaps = 49/353 (13%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 D+V+ + G+ + C+ D V + + + S A + + Sbjct: 81 KDVVYSASFRSDGKLL--CAGDATGLV-SVYDSYNPRTILLSINASTHP-THVTKFHTQD 136 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 +I+A+AS D+ +LW+ + L + + ++ F PA +A Sbjct: 137 NKILATASDDRVTRLWDIS--------NAYEPQLELTGATDYVRTLSFIPA-APHLVATG 187 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSI----------------------------P 160 DG++RLYD ++L + V ++ Sbjct: 188 SYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYE 247 Query: 161 PANHLQSDFCLSWCPSRFSPEK---LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRS 217 N ++ CL + + SP + +A S ++ + ++ K G + S Sbjct: 248 RGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSG---PVLS 304 Query: 218 ISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGR 277 + +PS + + + G G + I ++ E + + N S + +G Sbjct: 305 CAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGS 364 Query: 278 SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRL 330 +E + N +V + W+ G ++ L Sbjct: 365 EYQGDQE--HIIHNDKVRSQRRMRAFERNINQFKWSEALDNAFVPGMAKELTL 415 Score = 33.1 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 38/131 (29%), Gaps = 6/131 (4%) Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN 260 + + +A+L + + IS+ P + A ++IF + Sbjct: 28 RQYTSAQLVKEHNSVTHISFNP---QHPHDFAVTSSTR-VQIFSSRTRQVIKTFSRFKDV 83 Query: 261 SNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILS 320 +D + G + + L H V IL+ Sbjct: 84 VYSASFRSDGKLLCAGDATGLVSVYDSYNPR-TILLSINASTHPTHVTKFH-TQDNKILA 141 Query: 321 SAGDDGKVRLW 331 +A DD RLW Sbjct: 142 TASDDRVTRLW 152 >4AEZ-A nrPDB Length = 401 Score = 73.5 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 37/277 (13%), Positives = 95/277 (34%), Gaps = 40/277 (14%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRI 71 V V + G ++ + + ++ ++ T + H + + + W + Sbjct: 137 VASVKWSHDGSFLSVGLGNGLVDIYDVESQTK----LRTMAGHQARVGCLSWNR----HV 188 Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGND 131 ++S S + + +++ TL + + + GL+LA GND Sbjct: 189 LSSGSRSGAIHHHDVRIAN--------HQIGTLQGHSSEVCGLAWRSD--GLQLASGGND 238 Query: 132 GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQA 191 +++++DA + NH + ++WCP + + +++ Sbjct: 239 NVVQIWDARS-------------SIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQ 285 Query: 192 IIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCK-DGRIRIFKITEKLS 250 I + + S + S+ W+P ++++T D + I+ + Sbjct: 286 IHF---WNAATGARVNTVDAGSQVTSLIWSP---HSKEIMSTHGFPDNNLSIWSYSSSGL 339 Query: 251 PLASEESLTNSNMF--DNSADVDMDAQGRSDSNTEEK 285 + ++ + S D + + SD N + Sbjct: 340 TKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFW 376 Score = 59.6 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 17/146 (11%), Positives = 51/146 (34%), Gaps = 17/146 (11%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V + + G +A+ +D ++++ + + H++++ A+ W Sbjct: 215 GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKF----TKTNHNAAVKAVAWCPW 270 Query: 67 EYGRIIAS--ASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + ++A+ + DK + W + ++ + S+ ++P + Sbjct: 271 Q-SNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ----------VTSLIWSPHSKEIM 319 Query: 125 LACLGNDGILRLYDALEPSDLRSWTL 150 D L ++ + + Sbjct: 320 STHGFPDNNLSIWSYSSSGLTKQVDI 345 Score = 43.5 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 44/122 (36%), Gaps = 9/122 (7%) Query: 212 KSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVD 271 + + S+ W+ ++ G +G + I+ + + + Sbjct: 134 STYVASVKWSHD----GSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNR--H 187 Query: 272 MDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + + G +N Q+ L H+ EV ++W G L+S G+D V++W Sbjct: 188 VLSSGSRSGAIHHHDVRIANHQIGTL---QGHSSEVCGLAWRSDGLQLASGGNDNVVQIW 244 Query: 332 KA 333 A Sbjct: 245 DA 246 Score = 32.7 bits (72), Expect = 0.26, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 18/33 (54%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLD 39 HD V GR ++T +SD+++K +++ Sbjct: 347 AHDTRVLYSALSPDGRILSTAASDENLKFWRVY 379 >4A11-B nrPDB Length = 408 Score = 71.2 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 44/363 (12%), Positives = 107/363 (29%), Gaps = 71/363 (19%) Query: 8 HDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSN--WELSDSWR-------AHDSS 57 H ++ + + GR++ + SD I ++ L+ + + H S Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 58 IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQ--------------------------- 90 + + W + G + S+S+DKT+K+W+ + Q Sbjct: 102 VETVQWYPHDTG-MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVA 160 Query: 91 --------EECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEP 142 + C + + L + + +V ++P LA D ++L+D Sbjct: 161 VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP-RYDYILATASADSRVKLWDVRRA 219 Query: 143 SDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKL 202 S ++++ N +S S + + + G D ++ Sbjct: 220 S----------GCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRM 269 Query: 203 HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGC---------KDGRIRIFKITEKLSPLA 253 + G +L+ + + + + I ++ + Sbjct: 270 RLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITM 329 Query: 254 SEESLTNSNMFDNSADVDMDAQGRSDSNTEEK-----AELQSNLQVELLSEHDDHNGEVW 308 + + ++ G D N + + + S+ + + W Sbjct: 330 LKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAW 389 Query: 309 SVS 311 S S Sbjct: 390 SSS 392 Score = 68.1 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 42/267 (15%), Positives = 88/267 (32%), Gaps = 20/267 (7%) Query: 81 VKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDAL 140 ++L + + G + ++ P L G+DG++ LYD Sbjct: 16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML-SGGSDGVIVLYDLE 74 Query: 141 EPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDG 200 S +T + + P H S + W P + + D Sbjct: 75 NSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKV-----WDT 129 Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN 260 A + + + S +P + L+A G + ++++ + + Sbjct: 130 NTLQTADVFNFEETVYSHHMSPVSTKHC-LVAVGTRGPKVQLCDLKSGSCSHILQGHRQE 188 Query: 261 SNMFDNSADVD-MDAQGRSDSNTEEKAELQSNLQVELLSEHDD------------HNGEV 307 S D + A +DS + +++ + L +H+ HNG+V Sbjct: 189 ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKV 248 Query: 308 WSVSWNLTGTILSSAGDDGKVRLWKAT 334 + + G L + G D ++RLW ++ Sbjct: 249 NGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Score = 35.0 bits (78), Expect = 0.054, Method: Composition-based stats. Identities = 13/138 (9%), Positives = 40/138 (28%), Gaps = 22/138 (15%) Query: 5 DSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT-----SNWELSDSWRAHDSSIV 59 ++ H+ V+ + + G H+ T +D ++++ ++S + ++ Sbjct: 241 NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS 300 Query: 60 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 119 Y T+ ++ ++ L ++ F Sbjct: 301 C------GCSSEFVFVPYGSTIAVYTVYSG---------EQITMLKGHYKTVDCCVFQSN 345 Query: 120 HLGLKLACLGNDGILRLY 137 +L D + + Sbjct: 346 F--QELYSGSRDCNILAW 361 >2PM9-A nrPDB Length = 416 Score = 70.8 bits (171), Expect = 8e-13, Method: Composition-based stats. Identities = 40/302 (13%), Positives = 99/302 (32%), Gaps = 13/302 (4%) Query: 13 HDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRII 72 +D+ + + +A + ++++ ++ + + H SS+ + + + + ++ Sbjct: 71 NDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKF-NAKQDNVL 129 Query: 73 ASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDG 132 AS + + +W+ + E S S + S+ + L A G+ Sbjct: 130 ASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWN-QSLAHVFASAGSSN 188 Query: 133 ILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSAL-EQA 191 ++D ++ + TS P + Q + W P + A + + + Sbjct: 189 FASIWDLKAKKEVIHLSYTS-------PNSGIKQQLSVVEWHPKNSTRVATATGSDNDPS 241 Query: 192 IIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSP 251 I+ ++ + GH+ I S+ W + L+ + +D + ++ Sbjct: 242 ILIWDLRNANTPLQTLNQGHQKGILSLDWCH---QDEHLLLSSGRDNTVLLWNPESAEQL 298 Query: 252 LASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVS 311 + + S N E LQ+ E + E + Sbjct: 299 SQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQETETKQQESETDF 358 Query: 312 WN 313 WN Sbjct: 359 WN 360 Score = 46.5 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 54/338 (15%), Positives = 110/338 (32%), Gaps = 73/338 (21%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAID 62 F HD + V G A S+D ++++ L S ++ DS +D Sbjct: 17 TFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQV--DSKFNDLD 74 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 W+ +IIA A + +++L+ + + N + ++ S+ +VKF Sbjct: 75 WSHNN--KIIAGALDNGSLELYSTNE-----ANNAINSMARFSNHSSSVKTVKFNAKQDN 127 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK 182 LA GN+G + ++D + ++ PS ++P Sbjct: 128 -VLASGGNNGEIFIWDMNKCTE-----------------------------SPSNYTPLT 157 Query: 183 LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 + + S++W S+ + A+ I Sbjct: 158 ----------------------PGQSMSSVDEVISLAWNQSL---AHVFASAGSSNFASI 192 Query: 243 FKITEKLSPLASEESLTNSN------MFDNSADVDMDAQGRSDSNTEEKAEL--QSNLQV 294 + + K + + NS + + + S+ + + N Sbjct: 193 WDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANT 252 Query: 295 ELLSEHDDHNGEVWSVSW-NLTGTILSSAGDDGKVRLW 331 L + + H + S+ W + +L S+G D V LW Sbjct: 253 PLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLW 290 Score = 39.2 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 20/106 (18%), Positives = 49/106 (46%), Gaps = 3/106 (2%) Query: 232 ATGCKDGRIRIFKI--TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 A D + ++ + + P+AS + + N D S + + A + + E + + Sbjct: 39 ANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNE 98 Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLT-GTILSSAGDDGKVRLWKAT 334 +N + ++ +H+ V +V +N +L+S G++G++ +W Sbjct: 99 ANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMN 144 >6BX3-B nrPDB Length = 412 Score = 70.4 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 47/341 (13%), Positives = 121/341 (35%), Gaps = 30/341 (8%) Query: 14 DVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIA 73 + + G ++A ++ + ++ +D + AH I +I W+ GR++ Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPD--GRLLL 87 Query: 74 SASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGI 133 ++S D ++KLW+ + R ++ ++ A L +A + + Sbjct: 88 TSSRDWSIKLWDLSKPSKPLKEIR---------FDSPIWGCQWLDAKRRLCVATIFEESD 138 Query: 134 LRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAII 193 + D + + E ++ S P ++ + P+ + ++ Sbjct: 139 AYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNII----IVGTSKGWLDF 194 Query: 194 YQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLA 253 Y+ + L S I+ + + + R +A C D IR ++I+ A Sbjct: 195 YKFHSLYQTECIHSLKITSSNIKHLIVSQNGER----LAINCSDRTIRQYEISIDDENSA 250 Query: 254 SEESLTNSNM----------FDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDH 303 E +L + S + + ++ + + L+ + Sbjct: 251 VELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGA 310 Query: 304 NGEVWSVSWNL-TGTILSSAGDDGKVRLWKATYSNEFKCMS 343 E+ ++W+ + +I+S+ + G V +W ++ ++ Sbjct: 311 EEELIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALA 351 Score = 54.3 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 41/290 (14%), Positives = 84/290 (28%), Gaps = 24/290 (8%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H + + + GR + T S D IK++ L K + + DS I W Sbjct: 69 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRF----DSPIWGCQWLDA 124 Query: 67 EYGRIIAS--ASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 + +A+ D V + DP S +L + D G + H + Sbjct: 125 KRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVHTKHPNII 183 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 + D + L +K+ S + + S S + Sbjct: 184 IVGTSKGW----LDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLA-INCSDRTIR 238 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISW-----APSIGRWYQLIATGCKDGR 239 + I +L + K ++ +I + W + + + G Sbjct: 239 Q---YEISIDDENSAVELTLEHK---YQDVINKLQWNCILFSNNTAEYLVASTHGSSAHE 292 Query: 240 IRIFKITEKLSPLASEESLTNSNMFDNS-ADVDMDAQGRSDSNTEEKAEL 288 + I++ T E + + + + + G N + + Sbjct: 293 LYIWETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 342 >6CHG-A nrPDB Length = 312 Score = 70.0 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 44/286 (15%), Positives = 104/286 (36%), Gaps = 33/286 (11%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M + H + ++ + + + +A+ S D +++ + + H + +++ Sbjct: 46 MMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEITHI-----IYGRIRRLMGHTAPVIS 100 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 I + G I+ S+S D+++K W L T++ ++ S+ P Sbjct: 101 ICY--NNKGNILCSSSMDESIKEWHV---------LSGTALKTMSAHSDAVVSIDI-PKF 148 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 L+ DG++R++D L++ T + +S + Sbjct: 149 DSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIA--------EDGVVPISTVKFSRNG 200 Query: 181 EKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWY-----QLIATG 234 + L V +L+ + +++ + V L H+ + + + Y L+ +G Sbjct: 201 KFLLVKSLDNVVKLWEYTRG--TVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISG 258 Query: 235 CKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 G + ++ + K +E NS + SA D A + Sbjct: 259 NDSGSMCVWNVYSKNLVQKIDEKHRNSPLISISASYDKVATLSLNG 304 Score = 41.2 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 57/174 (32%), Gaps = 15/174 (8%) Query: 164 HLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPS 223 H + CL W P + +A + + + G++ +L GH + + SI + Sbjct: 53 HKECINCLCWSP---DSKCIASGSEDFTVEITHIIYGRIR---RLMGHTAPVISICYN-- 104 Query: 224 IGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSA-DVDMDAQGRSDSNT 282 ++ + D I+ + + + D D + + G D Sbjct: 105 --NKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLI 162 Query: 283 E----EKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 E L + +D + +V ++ G L D V+LW+ Sbjct: 163 RIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWE 216 Score = 33.4 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 36/97 (37%), Gaps = 5/97 (5%) Query: 235 CKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQV 294 C++ + +++I+ + N S D A G D E + ++ Sbjct: 31 CQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRIRR 90 Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + H V S+ +N G IL S+ D ++ W Sbjct: 91 LM-----GHTAPVISICYNNKGNILCSSSMDESIKEW 122 >5N4A-A nrPDB Length = 771 Score = 70.0 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 51/324 (15%), Positives = 109/324 (33%), Gaps = 51/324 (15%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRA-----HDS 56 Q + H +L V ++ + + TCS DQ I + + + + A H Sbjct: 7 QSSANVHSELTAAVGWNVWN-ELFTCSDDQTIHKWNMLGEPEQK--VSTLDAYFTDMHWY 63 Query: 57 SIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKF 116 + + + A A D +VK+ R ++ KG+ S+++ Sbjct: 64 PVSSKK-TQAGGTDVFAVACTDGSVKI----------LSRTGRVEKSIEGHKGACISLRW 112 Query: 117 APAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPS 176 + G LA G DG ++++ LRS ++ + + W Sbjct: 113 SYD--GTALATAGEDGSVKIWS--RNGMLRSTLAQAD------------SPVYSIVWA-- 154 Query: 177 RFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCK 236 + ++L +I + K + H ++ + W+P LI TG + Sbjct: 155 -YDCDQLCYCTGSNVVIKSLSSNAKQNAW---KAHDGVVLKVDWSPIN----HLIITGGE 206 Query: 237 DGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVEL 296 D + +++ +L + + ++ A G + + + Sbjct: 207 DCKYKVWDSFGRLLFQSGLFD-YPVTSVAWAPSGELFAVGGFN-TLQLCDRMGWAYSK-- 262 Query: 297 LSEHDDHNGEVWSVSWNLTGTILS 320 H + G + ++SW T L+ Sbjct: 263 --IHLNDTGSIMTLSWTADSTQLA 284 Score = 57.3 bits (136), Expect = 8e-09, Method: Composition-based stats. Identities = 40/237 (16%), Positives = 80/237 (33%), Gaps = 34/237 (14%) Query: 100 KLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSI 159 K + N +V + ++ +L +D + ++ L + + TL + Sbjct: 6 KQSSANVHSELTAAVGW---NVWNELFTCSDDQTIHKWNMLGEPEQKVSTL------DAY 56 Query: 160 PPANHLQSDFCLSWCPSRFSPEKLAVSALE-QAIIYQRGKDGKL----HVAAKLPGHKSL 214 H W P S +K + A+ G L V + GHK Sbjct: 57 FTDMH--------WYPV--SSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGA 106 Query: 215 IRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDA 274 S+ W+ +AT +DG ++I+ L ++ + + D D Sbjct: 107 CISLRWSYD----GTALATAGEDGSVKIWSRNGMLR-STLAQADSPVYSIVWAYDCDQLC 161 Query: 275 QGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + ++S + H+G V V W+ ++ + G+D K ++W Sbjct: 162 YCTGSNV-----VIKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVW 213 Score = 46.9 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 27/131 (20%), Positives = 52/131 (39%), Gaps = 16/131 (12%) Query: 211 HKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADV 270 H L ++ W + + T D I + + P +L ++ D Sbjct: 13 HSELTAAVGWN-----VWNELFTCSDDQTIHKWNMLG--EPEQKVSTL-DAYFTDMHWYP 64 Query: 271 DMDAQGRSDSNTEEKAELQSNLQVELLSEH-------DDHNGEVWSVSWNLTGTILSSAG 323 + ++ T+ A ++ V++LS + H G S+ W+ GT L++AG Sbjct: 65 -VSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAG 123 Query: 324 DDGKVRLWKAT 334 +DG V++W Sbjct: 124 EDGSVKIWSRN 134 >3ODT-A nrPDB Length = 313 Score = 70.0 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 85/277 (30%), Gaps = 54/277 (19%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIK---VFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 ++ V YD + D I +F + + L H ++ ++ + Sbjct: 59 QGFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLI----GHQGNVCSLSF-- 112 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS---VKFAPAHLG 122 + G +I S S+DKT K+W+E + + L S++ V F+ Sbjct: 113 -QDGVVI-SGSWDKTAKVWKE-----------GSLVYNLQAHNASVWDAKVVSFSENKF- 158 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK 182 D ++L+ + S ++ L++ H S Sbjct: 159 ---LTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSN------------ 203 Query: 183 LAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRI 242 L + + G V GH+S + I P+ I + +D +RI Sbjct: 204 ---DGLIKLVDMHTGD-----VLRTYEGHESFVYCIKLLPN-----GDIVSCGEDRTVRI 250 Query: 243 FKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSD 279 + + D ++ D+ + Sbjct: 251 WSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSSDN 287 Score = 56.2 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 87/292 (29%), Gaps = 44/292 (15%) Query: 44 NWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCT 103 ++LS + + HD + + +AS S D TV+LW +D +W Sbjct: 7 GYQLSATLKGHDQDVRDVVAVDDSK---VASVSRDGTVRLWSKD--------DQWLGTVV 55 Query: 104 LNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPAN 163 +G L SV + L G D ++ S + + Sbjct: 56 YTG-QGFLNSVCYDSEKE--LLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF 112 Query: 164 HLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPS 223 SW + A +++ G + L H + + A Sbjct: 113 QDGVVISGSW--------------DKTAKVWKEGS-----LVYNLQAHNASVWD---AKV 150 Query: 224 IGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTE 283 + T D I++++ + D +D + Sbjct: 151 VSFSENKFLTASADKTIKLWQ--NDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIK 208 Query: 284 EKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW-KAT 334 L ++L ++ H V+ + G I+ S G+D VR+W K Sbjct: 209 ----LVDMHTGDVLRTYEGHESFVYCIKLLPNGDIV-SCGEDRTVRIWSKEN 255 >5FA5-B nrPDB Length = 367 Score = 69.7 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 47/233 (20%), Positives = 79/233 (33%), Gaps = 34/233 (14%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 HDD+V V G + S D IKV+ L + + S+RAH + + + ASP Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV----VLSSYRAHAAQVTCVA-ASPH 203 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 + S S D + LW+ C C+ + S+ + P Sbjct: 204 KDSVFLSCSEDNRILLWDTR-----CPKPASQIGCSAPGYLPT--SLAWHPQQ-SEVFVF 255 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 +G + L D S + + A H Q L + P Sbjct: 256 GDENGTVSLVDTKSTSCV-------------LSSAVHSQCVTGLVFSPHSVPFLASLSED 302 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 A++ D L + H+ +R +W+P + L+ T D ++ Sbjct: 303 CSLAVL-----DSSLSELFRSQAHRDFVRDATWSPLN---HSLLTTVGWDHQV 347 Score = 33.8 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 13/134 (9%), Positives = 42/134 (31%), Gaps = 9/134 (6%) Query: 196 RGKDGKLHVAAKLPG--HKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLA 253 + + + +K H ++ ++S + +G KD I+++ + +++ + Sbjct: 132 ELDENETLIVSKFCKYEHDDIVSTVS----VLSSGTQAVSGSKDICIKVWDLAQQVVLSS 187 Query: 254 SEESLTNSNMFDNSA-DVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW 312 S + D+ ++ + S++W Sbjct: 188 YRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP--TSLAW 245 Query: 313 NLTGTILSSAGDDG 326 + + + GD+ Sbjct: 246 HPQQSEVFVFGDEN 259 >4OWR-A nrPDB Length = 339 Score = 69.3 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 47/337 (13%), Positives = 99/337 (29%), Gaps = 65/337 (19%) Query: 4 FDSGHDDLVHDVVYDFY---GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 S DD + + + G + S ++ +++ S + + + H ++ Sbjct: 5 VTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEV--QDSGQTIPKAQQMHTGPVLD 62 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 + W + G + +AS DKT K+W+ +Q + + ++ + A Sbjct: 63 VCW--SDDGSKVFTASCDKTAKMWDLSSNQA----------IQIAQHDAPVKTIHWIKAP 110 Query: 121 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP-------PANHLQSDFCLSW 173 + D L+ +D + + L + A + L Sbjct: 111 NYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLEN 170 Query: 174 CPSRF----------------------SPEKLAVSALEQAIIYQRGKDGK-LHVAAKLPG 210 PS F P A+ ++E + Sbjct: 171 QPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKC 230 Query: 211 HKSL------------IRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESL 258 H+S + I++ P G +AT DGR + + SE+ Sbjct: 231 HRSNGTNTSAPQDIYAVNGIAFHPVHG----TLATVGSDGRFSFWDKDARTKLKTSEQLD 286 Query: 259 TNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 295 + + + ++ A + S K N Q + Sbjct: 287 QPISACCFNHNGNIFA--YASSYDWSKGHEFYNPQKK 321 >3W15-A nrPDB Length = 368 Score = 68.9 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 54/353 (15%), Positives = 115/353 (32%), Gaps = 80/353 (22%) Query: 9 DDLVHDVVYD-FYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 D + D+ ++ + V D +++F + ++ H+ + + +W Sbjct: 62 QDCLFDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAI---FKEHEREVFSCNWNLVN 118 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGR------------------RWNKLCTLNDSKG 109 + S+S+D ++K+W Q + + ++ ++ Sbjct: 119 RQNFL-SSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN 177 Query: 110 SLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDF 169 +Y +F+P L L+C GN D+R + ++ L L DF Sbjct: 178 CVYQAQFSPHDQNLVLSCSGN-------SYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 230 Query: 170 CLSWCPSRFSPEKLAVSALEQAI-IYQ----RGKDGKLH----VAAKLPGHKSLIRSISW 220 ++ P +A ++ AI I+ G+LH + H IR ++W Sbjct: 231 N------KYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTW 284 Query: 221 APSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 +P ++ + D RI++ D Sbjct: 285 SP---HHSNILMSASYDMTCRIWRDLSN------------------------------DG 311 Query: 281 NTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT--ILSSAGDDGKVRLW 331 E ++ + H+ V+ W+L G ++S DG + +W Sbjct: 312 AKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVW 364 Score = 43.1 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 35/98 (35%), Gaps = 13/98 (13%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRH-VATCSSDQHIKVF---KLDKDTSNWELSDS------ 50 + + H + V + + + + + S D +++ D ++ + + Sbjct: 268 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 327 Query: 51 ---WRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 85 + H + DW+ +AS ++D + +W Sbjct: 328 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >6J6H-n nrPDB Length = 455 Score = 68.9 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 43/287 (14%), Positives = 88/287 (30%), Gaps = 32/287 (11%) Query: 46 ELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN 105 ++ ++ H A+ + P+ G +I S D T+K+W+ D + L Sbjct: 153 KVIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIWDFYHD--------YECLRDFQ 203 Query: 106 DSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHL 165 + +++F D ++++D L S + P N Sbjct: 204 GHNKPIKALRFTEDCQSFL--SSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN-- 259 Query: 166 QSDFCLSWCPSRFSPEKLAVSALEQAII-YQRGKDGKLHVAAKLPGHKSLIRSISWAPSI 224 P + V I+ Y + H S I ++ + P Sbjct: 260 --------------PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDG 305 Query: 225 GRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEE 284 + + +D +RI++ + ++ +S F N +S N Sbjct: 306 SK----FISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIY 361 Query: 285 KAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 L+ + H+ + +S +G D K RL+ Sbjct: 362 SFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 Score = 68.5 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 108/327 (33%), Gaps = 40/327 (12%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 GH + + + G + + +D IK++ D +E ++ H+ I A+ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRFT- 215 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 E + S+S+D++VK+W+ + + LN + + S P Sbjct: 216 -EDCQSFLSSSFDRSVKIWDTETGK-------VKTRLHLNSTPADVESRPTNPHEF---- 263 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 ++ + YD SE + L +HL S L + P + ++ Sbjct: 264 IVGLSNSKILHYD----------DRVSENQGLVQTYDHHLSSILALKYFPDG--SKFISS 311 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 S + I++ + + + H ++ + + D RI F + Sbjct: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQN------YFCAQSMDNRIYSFSL 365 Query: 246 TEKLS---PLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDD 302 K + + + D DS + + ++ + Sbjct: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 Query: 303 HNGEVWSVSWNLTGT-ILSSAGDDGKV 328 + + V W+ T + +G GK+ Sbjct: 426 NKP-ITQVDWHPQETSKVICSGAAGKI 451 Score = 48.1 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 22/187 (11%), Positives = 61/187 (32%), Gaps = 24/187 (12%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H + + Y G + S D+ +++++ + ++SD+ + H + + + Sbjct: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ-HSMPFLNV--HPSQ 348 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 + S D + + P + + + Y + A + G + Sbjct: 349 --NYFCAQSMDNRIYSFSLKPKYKR------HPKKIFKGHSSAGYGISLAFSGDGRYICS 400 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 + L +D W + + + IP + + W P + + + + A Sbjct: 401 GDSKSRLFTWD---------WNTSRLLNNIKIPGNKPITQ---VDWHP-QETSKVICSGA 447 Query: 188 LEQAIIY 194 + + Sbjct: 448 AGKIYVC 454 >5G04-R nrPDB Length = 499 Score = 68.5 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 60/178 (33%), Gaps = 39/178 (21%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 306 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 Query: 66 PEYGRIIAS--ASYDKTVKLWE---------EDPDQEECSG------------------- 95 + ++A+ + D+ +++W D + CS Sbjct: 366 WQ-SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 424 Query: 96 ------RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRS 147 K+ L + S+ +P G +A D LRL+ E R Sbjct: 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPD--GATVASAAADETLRLWRCFELDPARR 480 Score = 68.1 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 100/285 (35%), Gaps = 67/285 (23%) Query: 10 DLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG 69 + + V + G ++A +S ++++ + + + +H + + ++ W S Sbjct: 227 EYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKRLRNMTSHSARVGSLSWNS---- 278 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 129 I++S S + + + + + TL+ + +++AP G LA G Sbjct: 279 YILSSGSRSGHIHHHDVRVAE--------HHVATLSGHSQEVCGLRWAPD--GRHLASGG 328 Query: 130 NDGILRLYDAL--------------------------------------EPSDLRSWTLT 151 ND ++ ++ + +R W + Sbjct: 329 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 388 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 S + ++ H Q L W P A Q +I++ + A+L GH Sbjct: 389 SGACLSAV--DAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKY---PTMAKVAELKGH 442 Query: 212 KSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 256 S + S++ +P +A+ D +R+++ E L P E Sbjct: 443 TSRVLSLTMSPD----GATVASAAADETLRLWRCFE-LDPARRRE 482 Score = 50.4 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 58/172 (33%), Gaps = 10/172 (5%) Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 S + AL+ ++ G + ++ I S++W + +A G Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI----KEGNYLAVGTSSA 248 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 ++++ + ++ ++ + + G + + V LS Sbjct: 249 EVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLS 306 Query: 299 EHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW-KATYSNEFKCMSVITAQQ 349 H+ EV + W G L+S G+D V +W A + + T Q Sbjct: 307 ---GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 355 >6F1U-h nrPDB Length = 612 Score = 68.1 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 46/324 (14%), Positives = 98/324 (30%), Gaps = 28/324 (8%) Query: 15 VVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAH-DSSIVAIDWA--SPEYGRI 71 +V + A D V+ + + E H S++++ +A P + Sbjct: 269 LVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVF----HCQSAVMSATFAKFHP---NL 321 Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGND 131 + +Y + LW+ ++ R + +Y V L + D Sbjct: 322 VVGGTYSGQIVLWDNRSNKRTPVQRTP---LSAAAHTHPVYCVNVVGTQNAHNLISISTD 378 Query: 132 GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS--DFCLSWCPSRFSPEKLAVSALE 189 G + SW+L H QS S V + E Sbjct: 379 GKI-----------CSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEE 427 Query: 190 QAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGR--WYQLIATGCKDGRIRIFKITE 247 ++ K ++ GH+ I I ++G + L T D ++++ Sbjct: 428 GSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKN 487 Query: 248 KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEV 307 + E++ S + L ++ +V S + N + Sbjct: 488 NKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPAL 547 Query: 308 WSVSWNLTGTILSSAGDDGKVRLW 331 V W +G ++ +G++ ++ Sbjct: 548 NRVRWTHSGREIAVGDSEGQIVIY 571 >5CXC-A nrPDB Length = 510 Score = 67.7 bits (163), Expect = 7e-12, Method: Composition-based stats. Identities = 48/329 (14%), Positives = 92/329 (27%), Gaps = 28/329 (8%) Query: 19 FYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYD 78 V + S D ++++ S S H +SI A + + + +ASA D Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR---LASAGMD 212 Query: 79 KTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYD 138 +TV++W+ + + +G L GS+ + + DG + + Sbjct: 213 RTVRVWK-YTESDHFTGE-LKPTLELYGHTGSVDWLDVDGHSK--HILTASADGAIGFWS 268 Query: 139 ALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLS-----WCPSRFSPEKLAVSALEQAII 193 A + S +S W ++ + Sbjct: 269 ASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVA 328 Query: 194 YQRGKDGKLHVAAKLPGH-------KSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 Y +D + G + S+S G L+A G I + Sbjct: 329 YSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPR 388 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL-QVELLSEHDDHNG 305 + S +L S + + S + + +L V ++ + G Sbjct: 389 ASSAT-TSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLG 447 Query: 306 -------EVWSVSWNLTGTILSSAGDDGK 327 + SW G DG Sbjct: 448 GVSEPVYVIERESWASKGKKKRPVAGDGC 476 Score = 53.9 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 54/324 (16%), Positives = 96/324 (29%), Gaps = 62/324 (19%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V + D + +H+ T S+D I + K ++ + + A+ Sbjct: 238 GHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAH--VSKRRKATS 295 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 S + + LW + F P Sbjct: 296 S-----VSTAQRGPLGLWSI--------------------HTAPATAAIFDPRDR-TVAY 329 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 D +R D + + TLT + LS SP A + Sbjct: 330 SASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAG------------TTSPLLAAGT 377 Query: 187 ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + + L GH + + S+S +P + +G DG R++ + Sbjct: 378 SARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPEN---EYSLVSGSHDGTCRVWDLR 434 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGE 306 E SL S V + + S ++K + + Sbjct: 435 SVRPATKEEGSLGGV-----SEPVYVIERESWASKGKKKRPVA------------GDGCK 477 Query: 307 VWSVSWNLTGTILSSAGDDGKVRL 330 V+SV W+ G + S G+D KV++ Sbjct: 478 VFSVVWDKLG--IFSGGEDKKVQV 499 >4GGA-A nrPDB Length = 420 Score = 67.3 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 60/178 (33%), Gaps = 39/178 (21%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 227 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 286 Query: 66 PEYGRIIAS--ASYDKTVKLWE---------EDPDQEECSG------------------- 95 + ++A+ + D+ +++W D + CS Sbjct: 287 WQ-SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 345 Query: 96 ------RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRS 147 K+ L + S+ +P G +A D LRL+ E R Sbjct: 346 LVIWKYPTMAKVAELKGHTSRVLSLTMSPD--GATVASAAADETLRLWRCFELDPARR 401 Score = 66.6 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 100/285 (35%), Gaps = 67/285 (23%) Query: 10 DLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG 69 + + V + G ++A +S ++++ + + + +H + + ++ W S Sbjct: 148 EYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKRLRNMTSHSARVGSLSWNS---- 199 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 129 I++S S + + + + + TL+ + +++AP G LA G Sbjct: 200 YILSSGSRSGHIHHHDVRVAE--------HHVATLSGHSQEVCGLRWAPD--GRHLASGG 249 Query: 130 NDGILRLYDAL--------------------------------------EPSDLRSWTLT 151 ND ++ ++ + +R W + Sbjct: 250 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 309 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 S + ++ H Q L W P A Q +I++ + A+L GH Sbjct: 310 SGACLSAV--DAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKY---PTMAKVAELKGH 363 Query: 212 KSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 256 S + S++ +P +A+ D +R+++ E L P E Sbjct: 364 TSRVLSLTMSPD----GATVASAAADETLRLWRCFE-LDPARRRE 403 Score = 49.6 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 58/172 (33%), Gaps = 10/172 (5%) Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 S + AL+ ++ G + ++ I S++W + +A G Sbjct: 114 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI----KEGNYLAVGTSSA 169 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 ++++ + ++ ++ + + G + + V LS Sbjct: 170 EVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLS 227 Query: 299 EHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW-KATYSNEFKCMSVITAQQ 349 H+ EV + W G L+S G+D V +W A + + T Q Sbjct: 228 ---GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 276 >6CB1-s nrPDB Length = 569 Score = 67.3 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 58/380 (15%), Positives = 112/380 (29%), Gaps = 56/380 (14%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWE--LSDSWRAHDSSIVA 60 +GH V + D G +AT S D ++V+++ + L D D I Sbjct: 193 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC 252 Query: 61 IDWASPEYGRIIASASYDKTVKL------WEEDPD--QEECSGRRWNKLCTLNDSKGSLY 112 I+W I+A A + + ++ + + + G ++ T+ S + Sbjct: 253 IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVN 312 Query: 113 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP-ANHLQSDFCL 171 + A + ++ L + ++ + H + D+ + Sbjct: 313 ENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFV 372 Query: 172 SWCP------------------------------SRFSPEKLAVSALEQAIIYQRGKDGK 201 + P ++F P K + Q + + Sbjct: 373 TVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQ 432 Query: 202 LHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL-ASEESLTN 260 + V LPG + I P R LIA+ D R+ + +P Sbjct: 433 ILVKKLLPG-ARWLSKIDIHP---RGDNLIAS-SFDKRVLWHDLDLASTPYKTLRYHEKA 487 Query: 261 SNMFDNSADVDMDAQGRSDSN-----TEEKAELQSNLQVELLSEHDDHNGE----VWSVS 311 + + + + D ++ N + L + H V Sbjct: 488 VRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAI 547 Query: 312 WNLTGTILSSAGDDGKVRLW 331 W+ L SAG D RLW Sbjct: 548 WHPREAWLFSAGADNTARLW 567 Score = 41.9 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 38/298 (12%), Positives = 94/298 (31%), Gaps = 31/298 (10%) Query: 46 ELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN 105 S + H + + G +A+ S D TV++WE +GR + ++ Sbjct: 190 RCSTIYAGHKGKVRTLSIDPS--GLWLATGSDDGTVRVWE------ILTGREVYRTTLID 241 Query: 106 DSKGS---LYSVKFAPAHLGLKLACLGNDGILRL------YDALEPSDLRSWTLTSEMKV 156 D + + +++ P LA + I + YD + Sbjct: 242 DEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTF 301 Query: 157 LSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLP---GHKS 213 ++ +N ++ E + + + Q K + + + K Sbjct: 302 GTVKKSNLEVNEN----GDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKK 357 Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMD 273 ++ +SW G ++ + + + I ++++ L+ ++S Sbjct: 358 TVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 416 Query: 274 AQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++ + Q L+ + + + + G L ++ D +V LW Sbjct: 417 FVC-----SQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LW 468 Score = 33.8 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 267 SADVDMDAQGRSDSNTEEKAELQSNLQVELL---SEHDDHNGEVWSVSWNLTGTILSSAG 323 + V + ++ + +L+ + + + H G+V ++S + +G L++ Sbjct: 159 APRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGS 218 Query: 324 DDGKVRLWK 332 DDG VR+W+ Sbjct: 219 DDGTVRVWE 227 >6C0F-s nrPDB Length = 807 Score = 67.3 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 58/380 (15%), Positives = 112/380 (29%), Gaps = 56/380 (14%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWE--LSDSWRAHDSSIVA 60 +GH V + D G +AT S D ++V+++ + L D D I Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC 490 Query: 61 IDWASPEYGRIIASASYDKTVKL------WEEDPD--QEECSGRRWNKLCTLNDSKGSLY 112 I+W I+A A + + ++ + + + G ++ T+ S + Sbjct: 491 IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVN 550 Query: 113 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP-ANHLQSDFCL 171 + A + ++ L + ++ + H + D+ + Sbjct: 551 ENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFV 610 Query: 172 SWCP------------------------------SRFSPEKLAVSALEQAIIYQRGKDGK 201 + P ++F P K + Q + + Sbjct: 611 TVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQ 670 Query: 202 LHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL-ASEESLTN 260 + V LPG + I P R LIA+ D R+ + +P Sbjct: 671 ILVKKLLPG-ARWLSKIDIHP---RGDNLIAS-SFDKRVLWHDLDLASTPYKTLRYHEKA 725 Query: 261 SNMFDNSADVDMDAQGRSDSN-----TEEKAELQSNLQVELLSEHDDHNGE----VWSVS 311 + + + + D ++ N + L + H V Sbjct: 726 VRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAI 785 Query: 312 WNLTGTILSSAGDDGKVRLW 331 W+ L SAG D RLW Sbjct: 786 WHPREAWLFSAGADNTARLW 805 Score = 41.9 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 38/298 (12%), Positives = 94/298 (31%), Gaps = 31/298 (10%) Query: 46 ELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN 105 S + H + + G +A+ S D TV++WE +GR + ++ Sbjct: 428 RCSTIYAGHKGKVRTLSIDPS--GLWLATGSDDGTVRVWE------ILTGREVYRTTLID 479 Query: 106 DSKGS---LYSVKFAPAHLGLKLACLGNDGILRL------YDALEPSDLRSWTLTSEMKV 156 D + + +++ P LA + I + YD + Sbjct: 480 DEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTF 539 Query: 157 LSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLP---GHKS 213 ++ +N ++ E + + + Q K + + + K Sbjct: 540 GTVKKSNLEVNEN----GDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKK 595 Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMD 273 ++ +SW G ++ + + + I ++++ L+ ++S Sbjct: 596 TVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 654 Query: 274 AQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++ + Q L+ + + + + G L ++ D +V LW Sbjct: 655 FVC-----SQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LW 706 Score = 33.8 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 267 SADVDMDAQGRSDSNTEEKAELQSNLQVELL---SEHDDHNGEVWSVSWNLTGTILSSAG 323 + V + ++ + +L+ + + + H G+V ++S + +G L++ Sbjct: 397 APRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGS 456 Query: 324 DDGKVRLWK 332 DDG VR+W+ Sbjct: 457 DDGTVRVWE 465 >5LCW-Q nrPDB Length = 374 Score = 67.0 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 60/178 (33%), Gaps = 39/178 (21%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 181 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 240 Query: 66 PEYGRIIAS--ASYDKTVKLWE---------EDPDQEECSG------------------- 95 + ++A+ + D+ +++W D + CS Sbjct: 241 WQ-SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 299 Query: 96 ------RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRS 147 K+ L + S+ +P G +A D LRL+ E R Sbjct: 300 LVIWKYPTMAKVAELKGHTSRVLSLTMSPD--GATVASAAADETLRLWRCFELDPARR 355 Score = 66.2 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 100/285 (35%), Gaps = 67/285 (23%) Query: 10 DLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG 69 + + V + G ++A +S ++++ + + + +H + + ++ W S Sbjct: 102 EYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKRLRNMTSHSARVGSLSWNS---- 153 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 129 I++S S + + + + + TL+ + +++AP G LA G Sbjct: 154 YILSSGSRSGHIHHHDVRVAE--------HHVATLSGHSQEVCGLRWAPD--GRHLASGG 203 Query: 130 NDGILRLYDAL--------------------------------------EPSDLRSWTLT 151 ND ++ ++ + +R W + Sbjct: 204 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 263 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 S + ++ H Q L W P A Q +I++ + A+L GH Sbjct: 264 SGACLSAV--DAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKY---PTMAKVAELKGH 317 Query: 212 KSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEE 256 S + S++ +P +A+ D +R+++ E L P E Sbjct: 318 TSRVLSLTMSPD----GATVASAAADETLRLWRCFE-LDPARRRE 357 Score = 49.2 bits (115), Expect = 2e-06, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 58/172 (33%), Gaps = 10/172 (5%) Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 S + AL+ ++ G + ++ I S++W + +A G Sbjct: 68 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI----KEGNYLAVGTSSA 123 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 ++++ + ++ ++ + + G + + V LS Sbjct: 124 EVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLS 181 Query: 299 EHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW-KATYSNEFKCMSVITAQQ 349 H+ EV + W G L+S G+D V +W A + + T Q Sbjct: 182 ---GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 230 >6EM1-m nrPDB Length = 807 Score = 66.6 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 58/380 (15%), Positives = 112/380 (29%), Gaps = 56/380 (14%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWE--LSDSWRAHDSSIVA 60 +GH V + D G +AT S D ++V+++ + L D D I Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC 490 Query: 61 IDWASPEYGRIIASASYDKTVKL------WEEDPD--QEECSGRRWNKLCTLNDSKGSLY 112 I+W I+A A + + ++ + + + G ++ T+ S + Sbjct: 491 IEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVN 550 Query: 113 SVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP-ANHLQSDFCL 171 + A + ++ L + ++ + H + D+ + Sbjct: 551 ENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFV 610 Query: 172 SWCP------------------------------SRFSPEKLAVSALEQAIIYQRGKDGK 201 + P ++F P K + Q + + Sbjct: 611 TVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQ 670 Query: 202 LHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL-ASEESLTN 260 + V LPG + I P R LIA+ D R+ + +P Sbjct: 671 ILVKKLLPG-ARWLSKIDIHP---RGDNLIAS-SFDKRVLWHDLDLASTPYKTLRYHEKA 725 Query: 261 SNMFDNSADVDMDAQGRSDSN-----TEEKAELQSNLQVELLSEHDDHNGE----VWSVS 311 + + + + D ++ N + L + H V Sbjct: 726 VRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAI 785 Query: 312 WNLTGTILSSAGDDGKVRLW 331 W+ L SAG D RLW Sbjct: 786 WHPREAWLFSAGADNTARLW 805 Score = 41.9 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 38/298 (12%), Positives = 94/298 (31%), Gaps = 31/298 (10%) Query: 46 ELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN 105 S + H + + G +A+ S D TV++WE +GR + ++ Sbjct: 428 RCSTIYAGHKGKVRTLSIDPS--GLWLATGSDDGTVRVWE------ILTGREVYRTTLID 479 Query: 106 DSKGS---LYSVKFAPAHLGLKLACLGNDGILRL------YDALEPSDLRSWTLTSEMKV 156 D + + +++ P LA + I + YD + Sbjct: 480 DEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTF 539 Query: 157 LSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLP---GHKS 213 ++ +N ++ E + + + Q K + + + K Sbjct: 540 GTVKKSNLEVNEN----GDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKK 595 Query: 214 LIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMD 273 ++ +SW G ++ + + + I ++++ L+ ++S Sbjct: 596 TVKKLSWH-RKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 654 Query: 274 AQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++ + Q L+ + + + + G L ++ D +V LW Sbjct: 655 FVC-----SQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LW 706 Score = 33.8 bits (75), Expect = 0.11, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 267 SADVDMDAQGRSDSNTEEKAELQSNLQVELL---SEHDDHNGEVWSVSWNLTGTILSSAG 323 + V + ++ + +L+ + + + H G+V ++S + +G L++ Sbjct: 397 APRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGS 456 Query: 324 DDGKVRLWK 332 DDG VR+W+ Sbjct: 457 DDGTVRVWE 465 >5A31-R nrPDB Length = 386 Score = 66.2 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 36/242 (14%), Positives = 83/242 (34%), Gaps = 36/242 (14%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH D V + ++ + + + S D I + ++ +H + + W Sbjct: 170 SGHIDRVACLSWNNH--VLTSGSRDHRILHRDVRMPDP---FFETIESHTQEVCGLKWNV 224 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + +AS D V ++E G + + T ++ K ++ ++ ++P G L Sbjct: 225 AD--NKLASGGNDNVVHVYE---------GTSKSPILTFDEHKAAVKAMAWSPHKRG-VL 272 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 A G L+ W + + +K+ I + W + Sbjct: 273 ATGGG---------TADRRLKIWNVNTSIKMSDIDSG---SQICNMVWSKNTNELVTSHG 320 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + ++ + A L GH + + ++ + +G D +R +K+ Sbjct: 321 YSKYNLTLWDCNS---MDPIAILKGHSFRVLHL----TLSNDGTTVVSGAGDETLRYWKL 373 Query: 246 TE 247 + Sbjct: 374 FD 375 Score = 57.7 bits (137), Expect = 7e-09, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 91/280 (32%), Gaps = 40/280 (14%) Query: 55 DSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV 114 ++ ++ W G +A + V++++ + TL+ + + Sbjct: 131 ENEYTSLSWI--GAGSHLAVGQANGLVEIYDVMKR---------KCIRTLSGHIDRVACL 179 Query: 115 KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 + L D + D P +H Q L W Sbjct: 180 SWNNH----VLTSGSRDHRILHRDVRMPDPFFE------------TIESHTQEVCGLKW- 222 Query: 175 PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATG 234 + KLA + + G + HK+ +++++W+P ++ATG Sbjct: 223 --NVADNKLASGGNDNVVHVYEGTSKSPIL--TFDEHKAAVKAMAWSP---HKRGVLATG 275 Query: 235 CK--DGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL 292 D R++I+ + + + NM + + S ++ L Sbjct: 276 GGTADRRLKIWNVNTSIKMSDIDSGSQICNMV---WSKNTNELVTSHGYSKYNLTLWDCN 332 Query: 293 QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 ++ ++ H+ V ++ + GT + S D +R WK Sbjct: 333 SMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 372 Score = 39.6 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 48/127 (37%), Gaps = 9/127 (7%) Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS 267 L ++ S+SW IG +A G +G + I+ + ++ + + Sbjct: 127 LCDTENEYTSLSW---IGAGSH-LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN 182 Query: 268 ADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGK 327 + G D + + E + + H EV + WN+ L+S G+D Sbjct: 183 N--HVLTSGSRDHRILHRDVRMPDPFFETI---ESHTQEVCGLKWNVADNKLASGGNDNV 237 Query: 328 VRLWKAT 334 V +++ T Sbjct: 238 VHVYEGT 244 Score = 31.9 bits (70), Expect = 0.41, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 17/40 (42%), Gaps = 2/40 (5%) Query: 1 MQPFD--SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKL 38 M P GH V + G V + + D+ ++ +KL Sbjct: 334 MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 >5WLC-LS nrPDB Length = 594 Score = 66.2 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 52/350 (14%), Positives = 117/350 (33%), Gaps = 35/350 (10%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP---EY 68 + + + + T D+ ++++ +D T+ L S S I + + + Sbjct: 251 IQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTN--HLVTSLHLVGSPIQTCTFYTSLSNQN 308 Query: 69 GRIIASASYDKTVKLWEED-PDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 + I +A + + W+ + + K L + + S + K+A Sbjct: 309 QQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFE------NFKVAH 362 Query: 128 LGNDGILRLYDALEPSDLRSWTL---TSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK-- 182 L N ++ + W ++ L + +DFC+ + P + Sbjct: 363 LQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTI 422 Query: 183 -LAVSALEQAIIYQRGKDG----KLH------VAAKLPGHKSLIRSISWAPSIGRWYQLI 231 +AV+A + + K+G + + G + + S + + + Sbjct: 423 LIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWL 482 Query: 232 ATGCKDGRIRIFKITE------KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 A G + G + ++ A ++ T + S D + + Sbjct: 483 AVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALR 542 Query: 286 AELQSNLQVELLSEHDDHN-GEVWSVSWNLTGTILSSAGDDGKVRLWKAT 334 + V G+V SV+++ +G +L+ + GKVRLWK Sbjct: 543 LVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 >4N14-A nrPDB Length = 314 Score = 65.0 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 31/172 (18%), Positives = 59/172 (34%), Gaps = 39/172 (22%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH V + + GRH+A+ +D + V+ W ++ H ++ A+ W Sbjct: 143 SGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 202 Query: 66 PEYGRIIAS--ASYDKTVKLWE---------EDPDQEECSG------------------- 95 + ++A+ + D+ +++W D + CS Sbjct: 203 WQ-SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQ 261 Query: 96 ------RRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALE 141 K+ L + S+ +P G +A D LRL+ E Sbjct: 262 LVIWKYPTMAKVAELKGHTSRVLSLTMSPD--GATVASAAADETLRLWRCFE 311 Score = 63.1 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 41/274 (14%), Positives = 96/274 (35%), Gaps = 66/274 (24%) Query: 10 DLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG 69 + + V + G ++A +S ++++ + + + +H + + ++ W S Sbjct: 64 EYISSVAWIKEGNYLAVGTSSAEVQLWDV----QQQKRLRNMTSHSARVGSLSWNS---- 115 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 129 I++S S + + + + + TL+ + +++AP G LA G Sbjct: 116 YILSSGSRSGHIHHHDVRVAE--------HHVATLSGHSQEVCGLRWAPD--GRHLASGG 165 Query: 130 NDGILRLYDAL--------------------------------------EPSDLRSWTLT 151 ND ++ ++ + +R W + Sbjct: 166 NDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVC 225 Query: 152 SEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGH 211 S + ++ H Q L W P A Q +I++ + A+L GH Sbjct: 226 SGACLSAV--DAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKY---PTMAKVAELKGH 279 Query: 212 KSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 S + S++ +P +A+ D +R+++ Sbjct: 280 TSRVLSLTMSPD----GATVASAAADETLRLWRC 309 Score = 48.1 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 58/172 (33%), Gaps = 10/172 (5%) Query: 179 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 S + AL+ ++ G + ++ I S++W + +A G Sbjct: 30 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWI----KEGNYLAVGTSSA 85 Query: 239 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLS 298 ++++ + ++ ++ + + G + + V LS Sbjct: 86 EVQLWDVQQQKRLRNMTSHSARVGSLSWNS--YILSSGSRSGHIHHHDVRVAEHHVATLS 143 Query: 299 EHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW-KATYSNEFKCMSVITAQQ 349 H+ EV + W G L+S G+D V +W A + + T Q Sbjct: 144 ---GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQ 192 >4BH6-A nrPDB Length = 308 Score = 64.7 bits (155), Expect = 6e-11, Method: Composition-based stats. Identities = 37/243 (15%), Positives = 84/243 (34%), Gaps = 36/243 (14%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 SGH D V + ++ + + + S D I + ++ +H + + W Sbjct: 101 SGHIDRVACLSWNNH--VLTSGSRDHRILHRDVRMPDP---FFETIESHTQEVCGLKWNV 155 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + +AS D V ++E G + + T ++ K ++ ++ ++P G L Sbjct: 156 AD--NKLASGGNDNVVHVYE---------GTSKSPILTFDEHKAAVKAMAWSPHKRG-VL 203 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 A G L+ W + + +K+ I + W + Sbjct: 204 ATGGG---------TADRRLKIWNVNTSIKMSDIDSG---SQICNMVWSKNTNELVTSHG 251 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + ++ + A L GH + + ++ + +G D +R +K+ Sbjct: 252 YSKYNLTLWDCNS---MDPIAILKGHSFRVLHL----TLSNDGTTVVSGAGDETLRYWKL 304 Query: 246 TEK 248 +K Sbjct: 305 FDK 307 Score = 55.8 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 91/280 (32%), Gaps = 40/280 (14%) Query: 55 DSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV 114 ++ ++ W G +A + V++++ + TL+ + + Sbjct: 62 ENEYTSLSWI--GAGSHLAVGQANGLVEIYDVMKR---------KCIRTLSGHIDRVACL 110 Query: 115 KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 + L D + D P +H Q L W Sbjct: 111 SWNNH----VLTSGSRDHRILHRDVRMPDPFFE------------TIESHTQEVCGLKW- 153 Query: 175 PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATG 234 + KLA + + G + HK+ +++++W+P ++ATG Sbjct: 154 --NVADNKLASGGNDNVVHVYEGTSKSPIL--TFDEHKAAVKAMAWSP---HKRGVLATG 206 Query: 235 CK--DGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL 292 D R++I+ + + + NM + + S ++ L Sbjct: 207 GGTADRRLKIWNVNTSIKMSDIDSGSQICNMV---WSKNTNELVTSHGYSKYNLTLWDCN 263 Query: 293 QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 ++ ++ H+ V ++ + GT + S D +R WK Sbjct: 264 SMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 303 Score = 38.8 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 24/127 (18%), Positives = 48/127 (37%), Gaps = 9/127 (7%) Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS 267 L ++ S+SW IG +A G +G + I+ + ++ + + Sbjct: 58 LCDTENEYTSLSW---IGAGSH-LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN 113 Query: 268 ADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGK 327 + G D + + E + + H EV + WN+ L+S G+D Sbjct: 114 N--HVLTSGSRDHRILHRDVRMPDPFFETI---ESHTQEVCGLKWNVADNKLASGGNDNV 168 Query: 328 VRLWKAT 334 V +++ T Sbjct: 169 VHVYEGT 175 Score = 31.5 bits (69), Expect = 0.60, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 17/40 (42%), Gaps = 2/40 (5%) Query: 1 MQPFD--SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKL 38 M P GH V + G V + + D+ ++ +KL Sbjct: 265 MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >5OQL-X nrPDB Length = 630 Score = 63.1 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 36/212 (16%), Positives = 65/212 (30%), Gaps = 18/212 (8%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 + H D V + + + +CS D+ +KV+ LD+ ++ H I+ ID A Sbjct: 285 TQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDE----LAYVETLFGHQDEILDID-AL 339 Query: 66 PEYGRIIASASYDKTVKLWEE-DPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL- 123 + + A D+T + W+ + Q G K + AH G Sbjct: 340 GQERCVSVGA-RDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSM 398 Query: 124 ---------KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 ++G L L+ L ++ S Sbjct: 399 DRVAMIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSII 458 Query: 175 PSRFSPEKLAVSA-LEQAIIYQRGKDGKLHVA 205 P+ A+ +I+ DG + V Sbjct: 459 PAPQPRGITALRTLPYSDLIFSGSWDGCIRVW 490 Score = 58.9 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 41/270 (15%), Positives = 82/270 (30%), Gaps = 44/270 (16%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V G+ V T +D+ + V+ + + ++ H ++ + + Sbjct: 244 GHLKAPLVVKASQDGKFVVTGGADKRLVVYNAA----DLKPIKAFTQHRDAVTGLAFR-- 297 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + S S D+TVK+W D + TL + + + ++ Sbjct: 298 RGTNQLYSCSKDRTVKVWSLDE---------LAYVETLFGHQDEILDIDALGQER--CVS 346 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP------SRFSP 180 D R + E S L + D + + Sbjct: 347 VGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDD 406 Query: 181 EKLAVSAL-EQAIIYQRGKDGKLHVAAKLPGHK----------SLIRSISWAPS------ 223 + + ++ + LHV A+ G + I S P+ Sbjct: 407 DMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGI 466 Query: 224 ----IGRWYQLIATGCKDGRIRIFKITEKL 249 + LI +G DG IR+++++E Sbjct: 467 TALRTLPYSDLIFSGSWDGCIRVWRLSEDK 496 Score = 48.1 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 38/302 (12%), Positives = 81/302 (26%), Gaps = 57/302 (18%) Query: 78 DKTVKLWEEDPDQEECSGRRWNKLCTLNDS-----------KGSLYSVKFAPAHLGLKLA 126 D+ + D E G+ + +L + G++ SV P Sbjct: 129 DRDLLAERLKEDVAEAKGKVYRRLASELAFDKATYTQFRWNSGTVTSVAVCP----PYAY 184 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 DG L + + + T + P C + +R + +K Sbjct: 185 TTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPERICFAKADARKANDKTYQG 244 Query: 187 ALEQAIIYQRGKDGK------------------LHVAAKLPGHKSLIRSISWAPSIGRWY 228 L+ ++ + +DGK L H+ + +++ R Sbjct: 245 HLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFR----RGT 300 Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK--- 285 + + KD ++++ + E D + G D Sbjct: 301 NQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVP 360 Query: 286 ----------------AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVR 329 + L + H G + V+ + + + D+G + Sbjct: 361 EESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA-MIDDDMFVTGSDNGDLA 419 Query: 330 LW 331 LW Sbjct: 420 LW 421 Score = 41.9 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 16/115 (13%), Positives = 39/115 (33%), Gaps = 24/115 (20%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 M P + H+ + V T S + + ++ + + ++ + + I Sbjct: 387 MDPASAAHEGSMDRVAM-IDDDMFVTGSDNGDLALWSIQRKKPLHVIARAH-GLEPPIKL 444 Query: 61 IDWASPE----------------------YGRIIASASYDKTVKLWEEDPDQEEC 93 D+++ E Y +I S S+D +++W D+ + Sbjct: 445 EDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKL 499 >3ACP-A nrPDB Length = 417 Score = 63.1 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 36/86 (41%), Gaps = 6/86 (6%) Query: 4 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 63 D H + + + G + + S D +K++ + + + H +++ I Sbjct: 131 IDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVK----DGSNPRTLIGHRATVTDIAI 186 Query: 64 ASPEYGRIIASASYDKTVKLWEEDPD 89 + GR + SAS D T++LWE Sbjct: 187 I--DRGRNVLSASLDGTIRLWECGTG 210 Score = 60.8 bits (145), Expect = 7e-10, Method: Composition-based stats. Identities = 43/289 (14%), Positives = 89/289 (30%), Gaps = 25/289 (8%) Query: 22 RHVATCSSDQHIKVFKLDKDTSNWELSDSW-RAHDSSIVAIDWASPEYGRIIASASYDKT 80 R +++ IKV SN+ L +AH S I + + G + S+S D Sbjct: 107 RRFILGTTEGDIKVLD-----SNFNLQREIDQAHVSEITKLKFFPS--GEALISSSQDMQ 159 Query: 81 VKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDAL 140 +K+W TL + ++ + G + DG +RL++ Sbjct: 160 LKIWSVKDGSNP---------RTLIGHRATVTDIAI--IDRGRNVLSASLDGTIRLWECG 208 Query: 141 EPSDLRSWTLTSEMKVLSIPPANHLQSDFCL-SWCPSRFSPEKLAVSALEQAIIYQRGKD 199 + + ++ A + +D L S+ + + + G Sbjct: 209 TGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVI 268 Query: 200 GKLHVAAKLPGHKSLIRSISWAPSI---GRWYQLIATGCKDGRIRIFKITEKLSPLASE- 255 +V +K + + S+ G I G ++G + + + P+ Sbjct: 269 TVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFL 328 Query: 256 -ESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDH 303 T N +A + G S + + + + E Sbjct: 329 INEGTPINNVYFAAGALFVSSGFDTSIKLDIISDPESERPAIEFETPTF 377 Score = 48.5 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 32/206 (15%), Positives = 58/206 (28%), Gaps = 28/206 (13%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH V D+ GR+V + S D I++++ T+ + HD + Sbjct: 176 GHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGT 235 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVK--FA------- 117 + S S + + K + + +V F+ Sbjct: 236 DRQLHEISTS------------KKNNLEFGTYGKY-VIAGHVSGVITVHNVFSKEQTIQL 282 Query: 118 PAHLGLKLACLGNDGILR--LYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 175 P+ L DG +Y E L W L S + N + + Sbjct: 283 PSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFA- 341 Query: 176 SRFSPEKLAVSALEQAIIYQRGKDGK 201 + S + +I D + Sbjct: 342 ---AGALFVSSGFDTSIKLDIISDPE 364 Score = 41.9 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 11/103 (10%), Positives = 31/103 (30%), Gaps = 5/103 (4%) Query: 209 PGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSA 268 H S I + + PS + + + +D +++I+ + + +P Sbjct: 133 QAHVSEITKLKFFPS----GEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIID 188 Query: 269 DVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVS 311 D + + ++ + V S++ Sbjct: 189 RGRNVLSASLDGTIRLWECGTGT-TIHTFNRKENPHDGVNSIA 230 Score = 31.9 bits (70), Expect = 0.41, Method: Composition-based stats. Identities = 16/104 (15%), Positives = 33/104 (31%), Gaps = 4/104 (3%) Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 + G +G I++ L + ++ + D + + Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVK 166 Query: 289 QSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 + L+ H V ++ G + SA DG +RLW+ Sbjct: 167 DGSNPRTLI----GHRATVTDIAIIDRGRNVLSASLDGTIRLWE 206 >4G56-B nrPDB Length = 357 Score = 62.3 bits (149), Expect = 3e-10, Method: Composition-based stats. Identities = 40/234 (17%), Positives = 72/234 (30%), Gaps = 34/234 (14%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 HDD+V + G + D +KV+ L + + S+ AH S + + A P Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKA----VLKSYNAHSSEVNCVA-ACPG 192 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 I S D + LW+ + S SV + P AC Sbjct: 193 KDTIFLSCGEDGRILLWDTRKPKP-------ATRIDFCASDTIPTSVTWHP-EKDDTFAC 244 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 G + L + P ++ A H Q+ L++ Sbjct: 245 GDETGNVSLVNIKNPDSAQT-------------SAVHSQNITGLAYSYHSSPFLASISED 291 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIR 241 A++ D + H+ + ++W+P + T D ++ Sbjct: 292 CTVAVL-----DADFSEVFRDLSHRDFVTGVAWSPL---DHSKFTTVGWDHKVL 337 Score = 45.8 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 33/234 (14%), Positives = 74/234 (31%), Gaps = 22/234 (9%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 + + V + + + G + L++ LE L V H Sbjct: 94 EAGVTDVAWVSEKG---ILVASDSGAVELWEILEKESL---------LVNKFAKYEHDDI 141 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW 227 LS FS AVS + + + V H S + ++ P Sbjct: 142 VKTLS----VFSDGTQAVSGGKDFSVKVWDLS-QKAVLKSYNAHSSEVNCVAACPG---K 193 Query: 228 YQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE 287 + + +DGRI ++ + + +++ + + D T + Sbjct: 194 DTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSL 253 Query: 288 LQSNLQVELLSEHDDHNGEVWSVSWNL-TGTILSSAGDDGKVRLWKATYSNEFK 340 + + H+ + ++++ + L+S +D V + A +S F+ Sbjct: 254 VNIK-NPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFR 306 >5K19-A nrPDB Length = 569 Score = 62.0 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 23/158 (14%), Positives = 50/158 (31%), Gaps = 20/158 (12%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 + +++ + G+ +A S D ++VF D EL + +++ ++ + W+ Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDS----VELHGTMKSYFGGLLCVCWSPD-- 273 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP-----AHLGL 123 G+ I + D V +W + G K + V F P Sbjct: 274 GKYIVTGGEDDLVTVWSFVDCRVIARGH---------GHKSWVSVVAFDPYTTSVEEGDP 324 Query: 124 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPP 161 ++ L + + S+ P Sbjct: 325 MEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRP 362 Score = 50.8 bits (119), Expect = 8e-07, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 42/136 (30%), Gaps = 19/136 (13%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS-----P 66 + V + G+++ T D + V+ + + H S + + + Sbjct: 265 LLCVCWSPDGKYIVTGGEDDLVTVWSFV----DCRVIARGHGHKSWVSVVAFDPYTTSVE 320 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 E + S S +ED GR SK S P + + Sbjct: 321 EGDPMEFSGS--------DEDFQDLLHFGRDRANSTQSRLSKR--NSTDSRPVSVTYRFG 370 Query: 127 CLGNDGILRLYDALEP 142 +G D L L+D E Sbjct: 371 SVGQDTQLCLWDLTED 386 Score = 42.7 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 20/115 (17%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 +G+L F+P G LAC+ DG LR++ + S L MK ++ Sbjct: 220 EGALNEFAFSPD--GKFLACVSQDGFLRVF------NFDSVELHGTMK-------SYFGG 264 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAP 222 C+ W P + + + + D + V A+ GHKS + +++ P Sbjct: 265 LLCVCWSP---DGKYIVTGGEDDLVTVWSFVDCR--VIARGHGHKSWVSVVAFDP 314 Score = 36.5 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 32/207 (15%), Positives = 60/207 (28%), Gaps = 35/207 (16%) Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 L + G ++L D ++ + + + C+ W P S +A Sbjct: 118 LLVGFSAGQVQLIDPIKKETSKLFNEERLID---------KSRVTCVKWVPGSESLFLVA 168 Query: 185 VSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 244 S+ + + P ++ L + S+A + + + Sbjct: 169 HSSGNM-----YLYNVEHTCGTTAPHYQLLKQGESFA------VHTCKSKSTRNPLLKWT 217 Query: 245 ITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHN 304 + E N F S D A D VEL + Sbjct: 218 VGEGA-----------LNEFAFSPDGKFLACVSQDGFLRVFNF----DSVELHGTMKSYF 262 Query: 305 GEVWSVSWNLTGTILSSAGDDGKVRLW 331 G + V W+ G + + G+D V +W Sbjct: 263 GGLLCVCWSPDGKYIVTGGEDDLVTVW 289 Score = 36.1 bits (81), Expect = 0.022, Method: Composition-based stats. Identities = 26/180 (14%), Positives = 60/180 (33%), Gaps = 17/180 (9%) Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALE--PSDLRSWTLTSEMKVLSIPPANHL 165 K + VK+ P L L + G + LY+ + + L + + ++ Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSS-GNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSK 207 Query: 166 QS-DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVA--------AKLPGHKSLIR 216 + + L W + + A S + + +DG L V + + + Sbjct: 208 STRNPLLKWTVGEGALNEFAFSPDGKFLAC-VSQDGFLRVFNFDSVELHGTMKSYFGGLL 266 Query: 217 SISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQG 276 + W+P G++ I TG +D + ++ + + ++ +G Sbjct: 267 CVCWSPD-GKY---IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322 >6E29-D nrPDB Length = 345 Score = 61.6 bits (147), Expect = 5e-10, Method: Composition-based stats. Identities = 59/344 (17%), Positives = 117/344 (34%), Gaps = 36/344 (10%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 SGH V ++ G +A+ D + ++ L+ ++ R H +I ++ Sbjct: 21 NTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMG----VARKLRGHSKNITSL 73 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 W GR + SA V LW+ G+R+ ++ + +Y + P + Sbjct: 74 SW--SRCGRYLLSACQGWKVILWDLQD------GKRYREVR----FRAPVYGAELHPWNH 121 Query: 122 GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPE 181 A L D + L D EP ++R + L S K S L+ + Sbjct: 122 HQFAAALFEDQPM-LVDITEPVEVR-YVLPSVPKRTSTETDPALREKQAKEDAKHMTTAI 179 Query: 182 KLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRS-ISWAPSIGRWYQLIATGCKDGRI 240 S +G+ + + + I S I + + + +D I Sbjct: 180 VYTASGDHLLAGTTKGRLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRII 239 Query: 241 RIFKITE----KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQV-- 294 R F + L P + L + D + + S + A +N ++ Sbjct: 240 RTFIVPNLSAADLDPDTIQLPLEHKFQ-DVVNRLSWNHVAFSATGEYVAASTYNNHELYI 298 Query: 295 ------ELLSEHDDHNGEVWSVSWNLTGTILSSAG-DDGKVRLW 331 L+ + E + W+ +L++ G + G++ +W Sbjct: 299 WERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIW 342 Score = 50.8 bits (119), Expect = 8e-07, Method: Composition-based stats. Identities = 42/295 (14%), Positives = 85/295 (28%), Gaps = 33/295 (11%) Query: 52 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 111 H + + G +AS D TV +W+ + L ++ Sbjct: 25 SGHS---TCVRF--NRKGDFLASGRVDGTVVIWDLET---------MGVARKLRGHSKNI 70 Query: 112 YSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCL 171 S+ ++ G L + L+D + R + + + P NH Q L Sbjct: 71 TSLSWS--RCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAAL 128 Query: 172 SWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLI 231 V + + A + K + ++ A + Sbjct: 129 FEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHL 188 Query: 232 ATGCKDGRIRIFKITEKLSPLASEES--------LTNSNMFDNSADVDMDAQGRSDSNTE 283 G GR+ I + + + + LT S D + N Sbjct: 189 LAGTTKGRLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLS 248 Query: 284 EKAELQSNLQVELLSEHDDHNGEVWSVSWN-----LTGTILSSAGDDG-KVRLWK 332 +Q+ L + V +SWN TG ++++ + ++ +W+ Sbjct: 249 AADLDPDTIQLPLEHKFQ---DVVNRLSWNHVAFSATGEYVAASTYNNHELYIWE 300 >4PSX-B nrPDB Length = 401 Score = 60.4 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 39/244 (15%), Positives = 84/244 (34%), Gaps = 18/244 (7%) Query: 8 HDDLVHDVVYDFYGR-HVATCSSDQHIKVFKLDKDTSNWELSDSWRA-HDSSIVAIDWAS 65 H D + + + + + + S D + ++++ + +W H I W + Sbjct: 159 HKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHN 218 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 + + S D +K+ + + + + ++ F+ H L Sbjct: 219 FNK-DLFGTVSEDSLLKINDVRANNTTIDTVKCPQ---------PFNTLAFS-HHSSNLL 267 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 A G D + LYD + E V ++ + H+ S +R L Sbjct: 268 AAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQ 327 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 EQ +DG + GH+S + P I L+A+ ++ ++++K Sbjct: 328 IGAEQ--TPDDAEDGVPELIMVHAGHRSSVNDFDLNPQI---PWLVASAEEENILQVWKC 382 Query: 246 TEKL 249 + L Sbjct: 383 SHSL 386 Score = 51.6 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 51/332 (15%), Positives = 110/332 (33%), Gaps = 66/332 (19%) Query: 8 HDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H++ + Y VAT + ++ + L + + H + A+ +++ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG-----LQSTLKFHKDNGYALSFSTL 171 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSG-RRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 GR++ S S D TV LWE + R WN L + K+ Sbjct: 172 VKGRLL-SGSDDHTVALWEVGSGGDPTKPVRTWNDL-----HSDIINDNKWH-NFNKDLF 224 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 + D +L++ D T+ V P N L S S LA Sbjct: 225 GTVSEDSLLKINDVRA-------NNTTIDTVKCPQPFNTL--------AFSHHSSNLLAA 269 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + ++ +Y + GH+ + ++ ++ + ++ + D R+ ++ + Sbjct: 270 AGMDSY-VYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHV---DGVVVSSGSDNRLMMWDL 325 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNG 305 + + +++ EL+ H H Sbjct: 326 KQIGAEQTPDDAEDGV--------------------------------PELIMVHAGHRS 353 Query: 306 EVWSVSWNLTGT-ILSSAGDDGKVRLWKATYS 336 V N +++SA ++ +++WK ++S Sbjct: 354 SVNDFDLNPQIPWLVASAEEENILQVWKCSHS 385 Score = 40.8 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 40/252 (15%), Positives = 84/252 (33%), Gaps = 30/252 (11%) Query: 86 EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDL 145 E+ + R ++ + + + ++ P +A + G LY E Sbjct: 96 EEYQSSLPAPRSNIRITAKYEHEEEITRARYMPQDPN-IVATINGQGTTFLYSRSEG--- 151 Query: 146 RSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRGK--DGKL 202 L S +K H + + LS+ S +L + + + +++ G D Sbjct: 152 ----LQSTLKF-------HKDNGYALSF--STLVKGRLLSGSDDHTVALWEVGSGGDPTK 198 Query: 203 HVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSN 262 V H +I W L T +D ++I + + + + + N Sbjct: 199 PVRTWNDLHSDIINDNKWHNFN---KDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFN 255 Query: 263 MFDNSA-DVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWN--LTGTIL 319 S ++ A DS E L H V ++ ++ + G ++ Sbjct: 256 TLAFSHHSSNLLAAAGMDSYVYLYDLRNMK---EPLHHMSGHEDAVNNLEFSTHVDG-VV 311 Query: 320 SSAGDDGKVRLW 331 S+G D ++ +W Sbjct: 312 VSSGSDNRLMMW 323 >5A9Q-2 nrPDB Length = 326 Score = 60.0 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 49/267 (18%), Positives = 81/267 (30%), Gaps = 46/267 (17%) Query: 8 HDDLVHDVVYDFYGR--------HVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIV 59 H V + + R T ++D I++F D N H I Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEY--KVLEGHTDFIN 128 Query: 60 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 119 + + P+ G+ IAS S D T ++W + + + SV + P Sbjct: 129 GLVFD-PKEGQEIASVSDDHTCRIWNLE----------GVQTAHFVLHSPGM-SVCWHPE 176 Query: 120 HLGLKLACLGNDGILRLYDALEPSDLRS------------WTLTSEMKVLSIPPANHLQS 167 KL +G +R YD L + S W L + KV ++ + L Sbjct: 177 ET-FKLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIW 235 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLP--------GHKSLIRSIS 219 D S P P + + L + K+ GH I S Sbjct: 236 DITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGS 295 Query: 220 WAPSIGRWYQL---IATGCKDGRIRIF 243 A G + + D ++ + Sbjct: 296 VAVGSGLSWHRTLPLCVIGGDHKLLFW 322 Score = 48.1 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 56/134 (41%), Gaps = 19/134 (14%) Query: 7 GHDDLVHDVVYDF-YGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 GH D ++ +V+D G+ +A+ S D +++ L+ + + S +++ W Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVL------HSPGMSVCWHP 175 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 E +++ A + T++ ++ Q + +L + L S + + Sbjct: 176 EETFKLMV-AEKNGTIRFYDLLAQQA---------ILSLESEQVPLMSAHWCLKNTFKVG 225 Query: 126 ACLGNDGILRLYDA 139 A GND + ++D Sbjct: 226 AVAGNDWL--IWDI 237 >5BJS-A nrPDB Length = 605 Score = 60.0 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 52/140 (37%), Gaps = 12/140 (8%) Query: 7 GHDDLVHDVVYDFYGRHV-ATCSSDQHIKVFKLDKDTSNWELSDSW--RAHDSSIVAIDW 63 GH ++D+ ++ A+ S D I+++ L + H ++++ + Sbjct: 176 GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAF 235 Query: 64 ASPEYGRIIASASYDKTVKLWEE----DPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 119 + GR + SA +D+ + LW + E + + + V F Sbjct: 236 H--DNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--- 290 Query: 120 HLGLKLACLGNDGILRLYDA 139 + L L+ ++ + L+ Sbjct: 291 YGDLILSRACHEDTIVLWRI 310 Score = 47.3 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 87/284 (30%), Gaps = 67/284 (23%) Query: 62 DWASPEY--------GRIIASASYD------KTVKLWEEDPDQEECSGRRWNKLCTLNDS 107 W+ P++ G + AS S + +T ++++D G L D Sbjct: 24 AWSHPQFEKLEVLFQGPMPASDSAEWELPRLRTSFIFQDDYKYLGDDGSVSQDLAEFFDV 83 Query: 108 KGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 K YS AP A ++ D + ++ N Sbjct: 84 KFYPYSPPGAPPVFA---ATSKKHAVICRLTQTTDKDANPCEIIQLIR----DDGNEANC 136 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRW 227 C S P P +Y +GKL+ L GH I ++ +P+ Sbjct: 137 ASCWSKDPITDQPLLCIAGNEGNVKVY-NVTEGKLY--RTLVGHGGGINDLATSPAN--- 190 Query: 228 YQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE 287 +IA+ D IRI+ + + EK Sbjct: 191 PYIIASASDDTTIRIWSLAPE----------------------------------HEKQP 216 Query: 288 LQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + + H+ ++ SV+++ G + SAG D + LW Sbjct: 217 CVC------ILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 >5OV3-A nrPDB Length = 381 Score = 59.6 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 45/334 (13%), Positives = 92/334 (27%), Gaps = 43/334 (12%) Query: 15 VVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIAS 74 ++ +G +A +D I ++ ++ AH + ++ W G + S Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRG----IAKIISAHIHPVCSLCW--SRDGHKLVS 84 Query: 75 ASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGIL 134 AS D V W+ + R + + + V P + L + + Sbjct: 85 ASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHV 144 Query: 135 RLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIY 194 + + SDL E + + I+ Sbjct: 145 -VLPVDDDSDLNVV-------------------------ASFDRRGEYIYTGNAKGKILV 178 Query: 195 QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLAS 254 + L + ++ S +I + R D IR++ E L+ Sbjct: 179 LKTDSQDLVASFRVTTGTSNTTAIK-SIEFARKGSCFLINTADRIIRVYDGREILTCGRD 237 Query: 255 EESLTNSNMFDNSADVDMDAQGRS-------DSNTEEKAELQSNLQVELLSE--HDDHNG 305 E + D S + + A + L + H Sbjct: 238 GEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGE 297 Query: 306 EVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEF 339 + V+W+ I++S G V +W + Sbjct: 298 LLLDVAWHPVRPIIASISS-GVVSIWAQNQVENW 330 Score = 36.5 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 35/111 (31%), Gaps = 6/111 (5%) Query: 205 AAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMF 264 + G I S++ + RW L+A GC DGRI I+ + + Sbjct: 15 PEEADGTLDCI-SMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSL 73 Query: 265 DNSADVDMDAQGRSDSNTEEKAELQSNL-----QVELLSEHDDHNGEVWSV 310 S D +D+ + L + + + H + V Sbjct: 74 CWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKV 124 Score = 28.4 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 17/132 (12%), Positives = 41/132 (31%), Gaps = 26/132 (19%) Query: 19 FYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYD 78 + GR + TC D + + G I + S Sbjct: 226 YDGREILTCGRD---------GEPEPMQKLQDLVNRTPWKKCC---FSGDGEYIVAGSAR 273 Query: 79 KTVK-LWEEDPDQEECSGRRWNKLCTLNDSKGS-LYSVKFAPAHLGLKLACLGNDGILRL 136 + +WE+ + L+ ++G L V + P +A + + G++ + Sbjct: 274 QHALYIWEKSIGNL---------VKILHGTRGELLLDVAWHPVR--PIIASISS-GVVSI 321 Query: 137 YDALEPSDLRSW 148 + + + ++ Sbjct: 322 WAQNQVENWSAF 333 >5MWJ-A nrPDB Length = 337 Score = 59.6 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 84/271 (30%), Gaps = 40/271 (14%) Query: 9 DDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY 68 D+ + G + + ++ L T + + S+ A Sbjct: 97 DNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELT----SSAPACYALAISPD 152 Query: 69 GRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL 128 ++ S D + +W+ + + + + G KL Sbjct: 153 SKVCFSCCSDGNIAVWDLHNQTL---------VRQFQGHTDGASCIDIS--NDGTKLWTG 201 Query: 129 GNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSAL 188 G D +R +D E L+ TS++ L P + S + E L V+ Sbjct: 202 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES-----SNVEVLHVNKP 256 Query: 189 EQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEK 248 + +L H+S + S+ +A G+W + KD + ++ Sbjct: 257 D---------------KYQLHLHESCVLSLKFA-YCGKW---FVSTGKDNLLNAWRTPYG 297 Query: 249 LSPLASEESLTNSNMFDNSADVDMDAQGRSD 279 S S+ES ++ D S D G D Sbjct: 298 ASIFQSKES-SSVLSCDISVDDKYIVTGSGD 327 Score = 55.0 bits (130), Expect = 4e-08, Method: Composition-based stats. Identities = 45/283 (15%), Positives = 81/283 (28%), Gaps = 37/283 (13%) Query: 54 HDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS 113 H + A+ ++P + + VK+W+ + + + S Sbjct: 50 HGEVVCAVTISNPTR--HVYTGGK-GCVKVWDISHPG----NKSPVSQLDCLNRDNYIRS 102 Query: 114 VKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 173 K P G L G L ++D P+ LTS + L+ Sbjct: 103 CKLLPD--GCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPA-----------CYALAI 149 Query: 174 CPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIAT 233 P S + + ++ + + GH + I + T Sbjct: 150 SP--DSKVCFSCCSDGNIAVWDLHNQTLVR---QFQGHTDG----ASCIDISNDGTKLWT 200 Query: 234 GCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE-LQSNL 292 G D +R + + E + + + + A G SN E Sbjct: 201 GGLDNTVRSWDLREGRQLQQHDFT-SQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKY 259 Query: 293 QVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATY 335 Q+ L H V S+ + G S G D + W+ Y Sbjct: 260 QLHL------HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPY 296 Score = 51.2 bits (120), Expect = 6e-07, Method: Composition-based stats. Identities = 27/234 (11%), Positives = 73/234 (31%), Gaps = 14/234 (5%) Query: 107 SKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 + ++ H + A ++ +Y ++ W ++ + + L Sbjct: 41 HARQINTL----NHGEVVCAVTISNPTRHVY-TGGKGCVKVWDISHPGNKSPVSQLDCLN 95 Query: 167 SDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGR 226 D + C L V + + A+L +++ +P Sbjct: 96 RDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPD--- 152 Query: 227 WYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA 286 ++ + C DG I ++ + + + ++ D S D G D+ Sbjct: 153 -SKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 211 Query: 287 ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFK 340 + + D +++S+ + TG L+ + V + ++++ Sbjct: 212 LREGRQ-----LQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ 260 Score = 38.8 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 23/156 (14%), Positives = 44/156 (28%), Gaps = 19/156 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + G + T D ++ + L + + HD + Sbjct: 181 GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE-------GRQLQQHDFTSQIFSLGYC 233 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 G +A + E L+ + + S+KFA + G Sbjct: 234 PTGEWLAVG----------MESSNVEVLHVNKPDKYQLHLHESCVLSLKFA--YCGKWFV 281 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPA 162 G D +L + + + +S + I Sbjct: 282 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVD 317 Score = 27.7 bits (59), Expect = 9.1, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 14/36 (38%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKL 38 F S V +++ T S D+ V+++ Sbjct: 300 IFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 >3DWL-C nrPDB Length = 377 Score = 59.6 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 39/246 (15%), Positives = 85/246 (34%), Gaps = 23/246 (9%) Query: 13 HDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRII 72 ++ ++ T ++ +++++ D + W+ + ++ HD + +DWA I Sbjct: 15 YEHAFNSQRTEFVTTTATNQVELYEQDGN--GWKHARTFSDHDKIVTCVDWAP--KSNRI 70 Query: 73 ASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDG 132 + S D+ ++E+ PD W + L + V+++P A Sbjct: 71 VTCSQDRNAYVYEKRPD------GTWKQTLVLLRLNRAATFVRWSPNEDKF--AVGSGAR 122 Query: 133 ILRLYDALEPSDLRSWT-----LTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 ++ + + +D L S + L P N L + C S V A Sbjct: 123 VISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDA 182 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE 247 +A ++ A G + ++ ++PS +A D + I + Sbjct: 183 KPEASVWGSRLPFNTVCAEYPSGG--WVHAVGFSPS----GNALAYAGHDSSVTIAYPSA 236 Query: 248 KLSPLA 253 P Sbjct: 237 PEQPPR 242 Score = 54.3 bits (128), Expect = 7e-08, Method: Composition-based stats. Identities = 52/341 (15%), Positives = 112/341 (32%), Gaps = 32/341 (9%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 S HD +V V + + TCS D++ V++ D W+ + + + + W+ Sbjct: 52 SDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPD-GTWKQTLVLLRLNRAATFVRWSP 110 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 125 E + S + +V +E++ W + ++ S+ + P ++ L Sbjct: 111 NEDKFAVGSGARVISVCYFEQE-------NDWWVSKHLKRPLRSTILSLDWHPNNV--LL 161 Query: 126 ACLGNDGILRLY-----DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 A D + D + W + + + + P S Sbjct: 162 AAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSG-GWVHAVGFSP---SG 217 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAA--KLPGHKSLIRSISWAPSIG------RWYQLIA 232 LA + + ++ + A + + +RS+ WA + ++ Sbjct: 218 NALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVAAGYNYSPILL 277 Query: 233 TGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNL 292 G + G + S + + + V A + N + K QS Sbjct: 278 QGNESGWAHTRDLDAGTSKTSFTHTGNTGEGREEEGPVSFTALRSTFRNMDLKGSSQSIS 337 Query: 293 QVELLSEHDDHNGEVWSVSWNLTGTILS--SAGDDGKVRLW 331 + + ++ ++ G I + S+G DG+V LW Sbjct: 338 SLPTVHQNMIATLRPYA---GTPGNITAFTSSGTDGRVVLW 375 Score = 31.5 bits (69), Expect = 0.57, Method: Composition-based stats. Identities = 8/46 (17%), Positives = 16/46 (34%) Query: 300 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVI 345 DH+ V V W + + D +++ +K V+ Sbjct: 51 FSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVL 96 >5WBU-D nrPDB Length = 328 Score = 59.3 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 42/120 (35%), Gaps = 15/120 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSD----SWRAHDSSIVAID 62 H + +ATCS+DQ K+++ + ELS + + Sbjct: 220 AHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 279 Query: 63 WASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 ++ + I +AS D +LW + + + + ++ + F + LG Sbjct: 280 FSGD--SQYIVTASSDNLARLWCVETGEIK---------REYGGHQKAVVCLAFNDSVLG 328 Score = 56.6 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 46/327 (14%), Positives = 112/327 (34%), Gaps = 57/327 (17%) Query: 24 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 83 +AT D ++ + + + + + DS + A++ +IA+A Y + +++ Sbjct: 17 LATAGYDHTVRFW----QAHSGICTRTVQHQDSQVNALEVTPDR--SMIAAAGY-QHIRM 69 Query: 84 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEP- 142 ++ + + + + + ++ SV F G + G D R++D Sbjct: 70 YDLNSNNPN-------PIISYDGVNKNIASVGF--HEDGRWMYTGGEDCTARIWDLRSRN 120 Query: 143 -SDLRSWTLTSEMKVLSIPPAN-----------------------HLQSDFCLSWCPSRF 178 R + + + + + + P L + +S + Sbjct: 121 LQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 180 Query: 179 SPE---KLAVSALEQAIIYQ-----RGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQL 230 P+ AV++ ++ + +L K+P H ++P L Sbjct: 181 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPD----STL 236 Query: 231 IATGCKDGRIRIFKITE----KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKA 286 +AT D +I++ + + S +S + D+Q ++++ A Sbjct: 237 LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLA 296 Query: 287 ELQSNLQVELLSEHDDHNGEVWSVSWN 313 L E+ E+ H V +++N Sbjct: 297 RLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 50.4 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 39/267 (14%), Positives = 84/267 (31%), Gaps = 28/267 (10%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 G + + V + GR + T D +++ L + N + ++ ++ I + Sbjct: 85 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDL--RSRNLQCQRIFQV-NAPINCVCLHPN 141 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 + I+ S + +W+ D E + + + S+ S P +A Sbjct: 142 QAELIVGDQS--GAIHIWDLKTDHNE---------QLIPEPEVSITSAHIDPD--ASYMA 188 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 + + G +++ L + K+ + H + + P S S Sbjct: 189 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA-----HTRYALQCRFSP--DSTLLATCS 241 Query: 187 ALEQAIIYQRGK---DGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 A + I++ +L + + PG S R W + Q I T D R++ Sbjct: 242 ADQTCKIWRTSNFSLMTELSIKSGNPGESS--RGWMWGCAFSGDSQYIVTASSDNLARLW 299 Query: 244 KITEKLSPLASEESLTNSNMFDNSADV 270 + + V Sbjct: 300 CVETGEIKREYGGHQKAVVCLAFNDSV 326 Score = 42.3 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 18/109 (16%), Positives = 43/109 (39%), Gaps = 3/109 (2%) Query: 223 SIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT 282 ++G ++AT D +R ++ + + + N + + D M A + Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIA---AAGYQ 65 Query: 283 EEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 + ++ + +D N + SV ++ G + + G+D R+W Sbjct: 66 HIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIW 114 >3I2N-A nrPDB Length = 357 Score = 58.5 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 93/281 (33%), Gaps = 33/281 (11%) Query: 16 VYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEY----GRI 71 R++AT ++ ++ L+ S + H I AID Sbjct: 75 ATSLQQRYLATGDFGGNLHIWNLEAPEMP---VYSVKGHKEIINAIDGIGGLGIGEGAPE 131 Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA-HLGLKLACLGN 130 I + S D TVK+W+ + + + ++K ++V F A + ++ C G Sbjct: 132 IVTGSRDGTVKVWDPRQKDDPVANMEPVQ----GENKRDCWTVAFGNAYNQEERVVCAGY 187 Query: 131 D-GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE 189 D G ++L+D + W N L + S KL ++LE Sbjct: 188 DNGDIKLFDLRNMA--LRWET------------NIKNGVCSLEFDRKDISMNKLVATSLE 233 Query: 190 -QAIIYQRGKDGKLHVAAKL--PGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT 246 + ++ A + HKS + + P + +L T G + ++K Sbjct: 234 GKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLP---QNRELFLTAGGAGGLHLWKYE 290 Query: 247 EKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAE 287 + + + + + + ++ + + Sbjct: 291 YPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSP 331 Score = 46.5 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 41/131 (31%), Gaps = 13/131 (9%) Query: 18 DFYGRHVATCSSDQHIKVFKLDKDTSNWELSD-SWRAHDSSIVAIDWASPEYGRIIASAS 76 D + S + VF + + S +AH S++ + P+ + +A Sbjct: 221 DISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVR-HLPQNRELFLTAG 279 Query: 77 YDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKG----------SLYSVKFAPAHLGLKLA 126 + LW+ + + + S + S+ ++P G Sbjct: 280 GAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRG-LCV 338 Query: 127 CLGNDGILRLY 137 C D +R+ Sbjct: 339 CSSFDQTVRVL 349 Score = 38.1 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 57/165 (34%), Gaps = 19/165 (11%) Query: 106 DSKGSLYSVKFAPAHLGLKLAC--LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPAN 163 +++ K+ P G+++LY+ + Sbjct: 16 GFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK----------- 64 Query: 164 HLQSDFCLSWCPSRFSPEKLAVSALE-QAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAP 222 + C ++ + LA I+ + ++ V + GHK +I +I Sbjct: 65 -AKPIKCGTFGATSLQQRYLATGDFGGNLHIW-NLEAPEMPV-YSVKGHKEIINAIDGIG 121 Query: 223 SIGRWYQL--IATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 265 +G I TG +DG ++++ +K P+A+ E + N D Sbjct: 122 GLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRD 166 >2P9P-C nrPDB Length = 372 Score = 56.6 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 46/324 (14%), Positives = 93/324 (28%), Gaps = 17/324 (5%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H+ V V + + TC +D++ V+ L T L + + + WA E Sbjct: 51 HNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRI--NRAARCVRWAPNE 108 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 + S S ++ +E++ D C + + ++ S+ + P + LA Sbjct: 109 KKFAVGSGSRVISICYFEQENDWWVCKHIKKPI-------RSTVLSLDWHPNSV--LLAA 159 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 187 D R++ A T + S C FS V+ Sbjct: 160 GSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAW 219 Query: 188 LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITE 247 + K A L + ++++ + D +F Sbjct: 220 VSHDSTVCLADADKKMAVATLASETLPLLAVTFI-----TESSLVAAGHDCFPVLFTYDS 274 Query: 248 KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEV 307 L+ L + D + + ++ L ++ V Sbjct: 275 AAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISV 334 Query: 308 WSVSWNLTGTILSSAGDDGKVRLW 331 S + + G DG + +W Sbjct: 335 LSGG-KAKCSQFCTTGMDGGMSIW 357 Score = 53.5 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 32/287 (11%), Positives = 82/287 (28%), Gaps = 40/287 (13%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRI 71 + ++ +A C ++ + +++ + W + H+ + +DWA Sbjct: 11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGN--KWVQVHELKEHNGQVTGVDWAPD--SNR 66 Query: 72 IASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGND 131 I + D+ +W GR W + + V++AP A Sbjct: 67 IVTCGTDRNAYVW-------TLKGRTWKPTLVILRINRAARCVRWAPNEKKF--AVGSGS 117 Query: 132 GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP------SRFSPEKLAV 185 ++ + + +D W K + + L W P + K + Sbjct: 118 RVISICYFEQENDW--WVCKHIKKPI-------RSTVLSLDWHPNSVLLAAGSCDFKCRI 168 Query: 186 SALEQAIIYQRGKDGKLHVAAKL-------PGHKSLIRSISWAPSIGR-----WYQLIAT 233 + + +R + + ++ + R + Sbjct: 169 FSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCL 228 Query: 234 GCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 D ++ + + + PL + +T S++ D + Sbjct: 229 ADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDSA 275 Score = 36.9 bits (83), Expect = 0.013, Method: Composition-based stats. Identities = 17/137 (12%), Positives = 39/137 (28%), Gaps = 6/137 (4%) Query: 208 LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASE--ESLTNSNMFD 265 + H L+ IS + + IA + + I++ + E E D Sbjct: 1 MAYHSFLVEPIS-CHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVD 59 Query: 266 NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDD 325 + D + +D N + L+ + V W + Sbjct: 60 WAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARC--VRWAPNEKKFAVGSGS 117 Query: 326 GKVRL-WKATYSNEFKC 341 + + + ++ + C Sbjct: 118 RVISICYFEQENDWWVC 134 Score = 31.9 bits (70), Expect = 0.39, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 30/89 (33%), Gaps = 5/89 (5%) Query: 258 LTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT 317 + + + D A ++ + + + E +HNG+V V W Sbjct: 8 VEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQ--VHELKEHNGQVTGVDWAPDSN 65 Query: 318 ILSSAGDDGKVRLWKATYSNE-FKCMSVI 345 + + G D +W T +K VI Sbjct: 66 RIVTCGTDRNAYVW--TLKGRTWKPTLVI 92 >3JZG-A nrPDB Length = 402 Score = 56.2 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 42/322 (13%), Positives = 101/322 (31%), Gaps = 57/322 (17%) Query: 4 FDSGHDDLVHDVVYDFYGR----HVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIV 59 D+ D+ + + + +A S I++ + + H ++I Sbjct: 100 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT----MQCIKHYVGHGNAIN 155 Query: 60 AIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPA 119 + + P ++ S S D ++LW D + + + S + Sbjct: 156 ELKF-HPRDPNLLLSVSKDHALRLWNIQTDTLVAI------FGGVEGHRDEVLSADY--D 206 Query: 120 HLGLKLACLGNDGILRLYDA--------------LEPSDLRSWTLTSEMKVLSIP-PANH 164 LG K+ G D L+L+ P+ ++ ++ H Sbjct: 207 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIH 266 Query: 165 LQSDFCLSWCPSRFSPEKLAVSALEQAI-IYQRG-----------KDGKLHVAAKLPGHK 212 C+ W + + + E AI ++ G + + + + + Sbjct: 267 RNYVDCVRWL-----GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 321 Query: 213 SLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSN------MFDN 266 I + ++ W +++A G + G++ ++ + + A +LT+ Sbjct: 322 CDIWYMRFSMDF--WQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF 379 Query: 267 SADVDMDAQGRSDSNTEEKAEL 288 S D + D++ L Sbjct: 380 SRDSSILIAVCDDASIWRWDRL 401 Score = 55.4 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 56/190 (29%), Gaps = 6/190 (3%) Query: 150 LTSEMKVLSIPPANHLQSDFCLS--WCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAK 207 K ++ +H Q F + W P A + +Y+ G++ + Sbjct: 39 CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQS 98 Query: 208 L--PGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFD 265 + +W + L+A G IRI N Sbjct: 99 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELK 158 Query: 266 NSA-DVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGD 324 D ++ D L V + + H EV S ++L G + S G Sbjct: 159 FHPRDPNLLLSVSKDHALRLWNIQTDTL-VAIFGGVEGHRDEVLSADYDLLGEKIMSCGM 217 Query: 325 DGKVRLWKAT 334 D ++LW+ Sbjct: 218 DHSLKLWRIN 227 >5CXB-B nrPDB Length = 369 Score = 54.6 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 45/132 (34%), Gaps = 10/132 (7%) Query: 10 DLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG 69 + G ++ S D+ + LD ++ + R H +I A+ + Sbjct: 243 KWISSFDVHPGGDNLVVGSYDKRLLWHDLDLSNRPYK---TMRFHTEAIRAVRFHKGGL- 298 Query: 70 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKG----SLYSVKFAPAHLGLKL 125 + A AS D +++++ ++ + L K + + + P Sbjct: 299 PLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPRE--PWC 356 Query: 126 ACLGNDGILRLY 137 G DG RL+ Sbjct: 357 VSAGADGTARLW 368 Score = 53.1 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 60/365 (16%), Positives = 101/365 (27%), Gaps = 45/365 (12%) Query: 2 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 Q GH+ V V D G +AT D ++V++L W S D ++ + Sbjct: 14 QTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVW--SVKLNG-DEAVNTV 70 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFA---- 117 W + I+A+A+ + + P + + + + A Sbjct: 71 RWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILN-AGFGHATNGKQQANLPP 129 Query: 118 ----PAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSD--FCL 171 P L ++G+L SW + ++ P+ S L Sbjct: 130 GKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGD-HFATVSPSGQRSSVAIHTL 188 Query: 172 SWC--------------PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRS 217 S + F P + Q I KL + + I S Sbjct: 189 SKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQ-KLELVKIVQPGAKWISS 247 Query: 218 ISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPL-ASEESLTNSNMFDN-SADVDMDAQ 275 P + G D R+ + P + + A Sbjct: 248 FDVHP----GGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFAD 303 Query: 276 GRSDSNTEEKAELQSNLQVE-----LLSEHDDHNGE----VWSVSWNLTGTILSSAGDDG 326 D + + N Q+E + H V + W+ SAG DG Sbjct: 304 ASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADG 363 Query: 327 KVRLW 331 RLW Sbjct: 364 TARLW 368 Score = 47.7 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 41/106 (38%), Gaps = 14/106 (13%) Query: 88 PDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRS 147 P +E + +G + SV P G+ LA G+DG +R+++ L + S Sbjct: 1 PSPDELKPFPTVQQTIFRGHEGRVRSVAIDPT--GVALATGGDDGTVRVWELLTGRQVWS 58 Query: 148 WTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAII 193 L + ++ + W P++ + A + + ++ Sbjct: 59 VKLNGD------------EAVNTVRWRPTKDTFILAAAAGEDIFLM 92 Score = 36.9 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 16/49 (32%), Positives = 24/49 (48%), Gaps = 3/49 (6%) Query: 287 ELQSNLQVELLSE---HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 L+ + H G V SV+ + TG L++ GDDG VR+W+ Sbjct: 1 PSPDELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWE 49 >5A9Q-0 nrPDB Length = 380 Score = 54.3 bits (128), Expect = 7e-08, Method: Composition-based stats. Identities = 22/139 (15%), Positives = 49/139 (35%), Gaps = 11/139 (7%) Query: 1 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 60 ++ D+ +H V + + T +S +K++ + + S + Sbjct: 164 VRTIDNADSSTLHAVTF-LRTPEILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHC 222 Query: 61 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 120 +D P ++A+ D + +W+ + L + ++ V F P++ Sbjct: 223 VD-RHPNQQHVVATGGQDGMLSIWDVRQGT--------MPVSLLKAHEAEMWEVHFHPSN 273 Query: 121 LGLKLACLGNDGILRLYDA 139 L DG L +DA Sbjct: 274 P-EHLFTCSEDGSLWHWDA 291 Score = 53.9 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 48/317 (15%), Positives = 107/317 (33%), Gaps = 48/317 (15%) Query: 24 VATCSSDQH---IKVFKLDKDTSNWELSDSWRA---------HDSSIVAIDWASPEYGRI 71 AT S D I ++ + D N + + H ++ + + E Sbjct: 32 FATGSWDNEENYISLWSI-GDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQER--- 87 Query: 72 IASASYDKTVKLWEEDPDQEECS-GRRWNKLCTLNDSKGSLYSVKFAPAHL----GLKLA 126 I +AS V ++ P+ + S ++W YS AP ++ Sbjct: 88 IVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSS--APCTGVVCNNPEIV 145 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVS 186 +G DG + L+ A +R+ + ++ +PE L V+ Sbjct: 146 TVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLR---------------TPEILTVN 190 Query: 187 ALEQAIIY---QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIF 243 ++ Q I+ Q+G + + L G + + + P+ ++ATG +DG + I+ Sbjct: 191 SIGQLKIWDFRQQGNEPSQIL--SLTGDRVPLHCVDRHPN---QQHVVATGGQDGMLSIW 245 Query: 244 KITEKLSPLASEESLTNS--NMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHD 301 + + P++ ++ + + ++ + D + + L Sbjct: 246 DVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQG 305 Query: 302 DHNGEVWSVSWNLTGTI 318 + S S + + Sbjct: 306 GRSSTFLSHSISNQANV 322 Score = 38.5 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 29/236 (12%), Positives = 65/236 (27%), Gaps = 12/236 (5%) Query: 108 KGSLYSVKFAPAHLGLK-----LACLGNDGI---LRLYDALEPSDLRS---WTLTSEMKV 156 + ++ P G A D + L+ + +L S + ++ Sbjct: 10 SQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLC 69 Query: 157 LSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIR 216 + + F S L + + A G S Sbjct: 70 DIRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSY 129 Query: 217 SISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQG 276 S + + I T +DGRI +F+ K + + + +++ Sbjct: 130 SSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTV 189 Query: 277 RSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLW 331 S + Q + + + V + ++++ G DG + +W Sbjct: 190 NSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIW 245 Score = 32.7 bits (72), Expect = 0.23, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 15/39 (38%), Gaps = 1/39 (2%) Query: 7 GHDDLVHDVVYDFYG-RHVATCSSDQHIKVFKLDKDTSN 44 H+ + +V + H+ TCS D + + D Sbjct: 259 AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPE 297 >5YZG-2 nrPDB Length = 646 Score = 53.5 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 44/279 (15%), Positives = 91/279 (32%), Gaps = 59/279 (21%) Query: 54 HDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS 113 H I + I +AS+D VK W++ + E + G + S Sbjct: 89 HRDVITHVV---CTKTDFIITASHDGHVKFWKKIEEGIEF-------VKHFRSHLGVIES 138 Query: 114 VKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 173 + + G +G+D ++++D + + L + +C Sbjct: 139 IAVS--SEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYF--------PGQCEWIYCPGD 188 Query: 174 CPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIAT 233 S + + + + I RG + LH+ KL H S + I P Y+ + + Sbjct: 189 AISSVAASEKSTGKI--FIYDGRGDNQPLHIFDKL--HTSPLTQIRLNPV----YKAVVS 240 Query: 234 GCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQ 293 K G I + P + + + D+ A+ ++ + Sbjct: 241 SDKSGMIEYWTG----PPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTS----------- 285 Query: 294 VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWK 332 V ++ G +++ G D KVR+++ Sbjct: 286 ----------------VCFSPDGKKIATIGSDRKVRIFR 308 Score = 53.1 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 46/254 (18%), Positives = 86/254 (33%), Gaps = 21/254 (8%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D++ VV + T S D H+K +K ++ E +R+H I +I A Sbjct: 89 HRDVITHVVCTKTD-FIITASHDGHVKFWKKIEE--GIEFVKHFRSHLGVIESI--AVSS 143 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 G + S DK +K+++ KL +Y + A Sbjct: 144 EGALFCSVGDDKAMKVFDVVNFDMI----NMLKLGYFPGQCEWIYCPG---DAISSVAAS 196 Query: 128 LGNDGILRLYDAL-EPSDLRSWTLTSEMKVLSI-PPANHLQSDFCLSWCPSRFSPEKLAV 185 + G + +YD + L + + I + + Sbjct: 197 EKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHE 256 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 + + ++ D L+ AK + S+ ++P + IAT D ++RIF+ Sbjct: 257 YKFPKNVNWEYKTDTDLYEFAKCKAYP---TSVCFSPD----GKKIATIGSDRKVRIFRF 309 Query: 246 TEKLSPLASEESLT 259 +ESL+ Sbjct: 310 VTGKLMRVFDESLS 323 >5WYJ-BE nrPDB Length = 939 Score = 51.9 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 51/365 (13%), Positives = 105/365 (28%), Gaps = 62/365 (16%) Query: 7 GHDDLVHDVVYDFYGRH-VATCSSDQHIKVFKLDKDTSNWELS--------------DSW 51 GH + + H + + S D+ + F L KD + E+S + Sbjct: 348 GHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTI 407 Query: 52 RAHDSSIVAIDWASPEYGRI--IASASYDKT-VKLWEEDPDQEECSGRRWNKLCTLNDSK 108 ++ IVA+ + G I +A D+ + W+ RW T + Sbjct: 408 KSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMR----NKRVGRWTFDTTDDGFV 463 Query: 109 GSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSD 168 S+ A + G ++G + +Y+ + + L H ++ Sbjct: 464 KSV-----AMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKL-------------HKRAV 505 Query: 169 FCLSWCPSRFSPEKLAVSALEQAIIYQRGKD---GKLHVAAKLPGHKSLIRSISWAPSIG 225 +S + + ++ Y K GKL + A + ++ Sbjct: 506 TGISLD--GMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITA---MVYH-------- 552 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEK 285 R L A D I + + FD S + DS Sbjct: 553 RSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTW 612 Query: 286 AELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG-DDGKVRLWKATYSNEFKCMSV 344 ++ + +V ++ G +L++ + +W + Sbjct: 613 DLPTGGCIDGIIV-----DNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRT 667 Query: 345 ITAQQ 349 I + Sbjct: 668 IDESE 672 Score = 49.6 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 64/203 (31%), Gaps = 53/203 (26%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWEL-------------------- 47 H V + D R + +C D + + +K T +L Sbjct: 501 HKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFAL 560 Query: 48 -----------------SDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQ 90 H + I A D++ GR I SAS D T++ W+ P Sbjct: 561 ALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSP--EGRWIVSASLDSTIRTWDL-PTG 617 Query: 91 EECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACL--GNDGILRLYDALEPSDLRSW 148 G + + T +VKF+P G LA +GI + + + + Sbjct: 618 GCIDGIIVDNVAT---------NVKFSPN--GDLLATTHVTGNGICIWTNRAQFKTVSTR 666 Query: 149 TLTSEMKVLSIPPANHLQSDFCL 171 T+ P+ ++ + + Sbjct: 667 TIDESEFARMALPSTSVRGNDSM 689 >4E5Z-B nrPDB Length = 436 Score = 51.9 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 28/162 (17%), Positives = 54/162 (33%), Gaps = 21/162 (12%) Query: 14 DVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIA 73 + R V T + ++ + +D + R H + + +P +A Sbjct: 214 SLDVSASSRMVVTGDNVGNVILLNMDGKE-----LWNLRMHKKKVTHVAL-NPCCDWFLA 267 Query: 74 SASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGI 133 +AS D+TVK+W+ + + S + + + F+P G +L Sbjct: 268 TASVDQTVKIWDLRQVRGKAS------FLYSLPHRHPVNAACFSPD--GARLLTTDQKSE 319 Query: 134 LRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCP 175 +R+Y A W + HL +W P Sbjct: 320 IRVYSA------SQWDCPLGLIPHPHRHFQHLTPIKA-AWHP 354 Score = 45.0 bits (104), Expect = 4e-05, Method: Composition-based stats. Identities = 40/273 (14%), Positives = 76/273 (27%), Gaps = 34/273 (12%) Query: 55 DSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSV 114 D ++ W P + +A S + LW + + GS+ + Sbjct: 119 DRRATSLAW-HPTHPSTVAVGSKGGDIMLWNFGIKDK-------PTFIKGIGAGGSITGL 170 Query: 115 KFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWC 174 KF P + A +G RL D + + L Sbjct: 171 KFNPLNTNQFYAS-SMEGTTRLQDF-----------KGNILRVFASSDTINIWFCSLDVS 218 Query: 175 PSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATG 234 S ++ V+ + DG L HK + ++ P +AT Sbjct: 219 ASS----RMVVTGDNVGNVILLNMDG--KELWNLRMHKKKVTHVALNPCC---DWFLATA 269 Query: 235 CKDGRIRIFKITEKLSPLASEESL---TNSNMFDNSADVDMDAQGRSDSNTEEKAELQSN 291 D ++I+ + + + SL N S D S + Q + Sbjct: 270 SVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 329 Query: 292 LQVELLSEHDDHNGEVW--SVSWNLTGTILSSA 322 + L+ H + +W+ ++ Sbjct: 330 CPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVG 362 Score = 29.2 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 37/118 (31%), Gaps = 14/118 (11%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDK-DTSNWELSDSWR--AHDSSIVAIDWA 64 H V+ + G + T I+V+ + D + R H + I A W Sbjct: 295 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWH 353 Query: 65 SPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG 122 +I Y DP+ + C+ + + + G + + P G Sbjct: 354 P--RYNLIVVGRY--------PDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSG 401 >6CHG-D nrPDB Length = 439 Score = 51.9 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 58/360 (16%), Positives = 113/360 (31%), Gaps = 61/360 (16%) Query: 14 DVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIA 73 V + G ++A S+ I ++ +D L AH S+ ++ W++ GR + Sbjct: 32 CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSND--GRYLW 89 Query: 74 SASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS---VKFAPAHLGLKLACLGN 130 S+ D KLW+ + K G L+S V++ Sbjct: 90 SSGRDWYAKLWDM---------TQPTKCFQQYKFDGPLWSCHVVRW-------------- 126 Query: 131 DGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSD-----FCLSWCPSRFSPEKLAV 185 + + +E TLT P D + L CP + Sbjct: 127 --NVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIIT 184 Query: 186 SALE-----QAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 + + + G + K+ + + I+ I +PS R IA D I Sbjct: 185 GTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTR----IAINGSDRTI 240 Query: 241 RIFKITEKLSPLASEESLTNS----------------NMFDNSADVDMDAQGRSDSNTEE 284 R +++ + + S + S N S + ++ Sbjct: 241 RQYQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAH 300 Query: 285 KAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAG-DDGKVRLWKATYSNEFKCMS 343 L L+ + + E+ + WN ++S G + G V +W ++ ++ Sbjct: 301 DLYLWETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSIVIPPKWSALA 360 Score = 38.5 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 36/332 (10%), Positives = 95/332 (28%), Gaps = 28/332 (8%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 H V V + GR++ + D + K++ + + T ++ D + + Sbjct: 71 AHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKF----DGPLWSC--HVV 124 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEEC-SGRRWNKLCTLNDSKGSLYSVKFAPA-HLGLK 124 + I + + T + Q + ++ Y++ P + Sbjct: 125 RWNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHG---YTLVACPHPTIESI 181 Query: 125 LACLGNDGILRLYDA-LEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKL 183 + + G + + LE E K+ + + S + Sbjct: 182 IITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIR 241 Query: 184 AVSALEQAIIYQRGKDG--KLHVAAKLPG-HKSLIRSISW-----APSIGRWYQLIATGC 235 Q I+ +G V+ +L ++ +I + W + G + A G Sbjct: 242 Q----YQLIVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGS 297 Query: 236 KDGRIRIFKITEKLSPLASEESLTNSNMFDNS-ADVDMDAQGRSDSNTEEKAELQSNLQV 294 + +++ + E + D + + + + G + + + Sbjct: 298 SAHDLYLWETSSGSLVRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSIV---IPP 354 Query: 295 ELLSEHDDHNGEVWSVSWNLTGTILSSAGDDG 326 + + D ++ + DD Sbjct: 355 KWSALAPDFEEVEENIDYQEKENEFDIMDDDN 386 >3DW8-B nrPDB Length = 447 Score = 50.8 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 47/368 (12%), Positives = 114/368 (30%), Gaps = 53/368 (14%) Query: 5 DSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDT-------SNWELSDSWRAHDSS 57 D D++ V ++ G +AT + +F+ +++ + + ++++H+ Sbjct: 24 DVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPE 83 Query: 58 ------------IVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLN 105 I I W + ++ DKT+KLW+ + G + Sbjct: 84 FDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRY 143 Query: 106 DSKGSLYSVK---FAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPA 162 ++ +++ F P L +E S R + + SI Sbjct: 144 RDPTTVTTLRVPVFRPMDL-----------------MVEASPRRIFANAHTYHINSISIN 186 Query: 163 NHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAP 222 + ++ ++ + I + V H + + ++ Sbjct: 187 SDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSS 246 Query: 223 SIG--RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDS 280 S G R + A+ D ++F+ E S + + +S + R Sbjct: 247 SKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYL 306 Query: 281 NTEEKAELQSNLQVELLSEHDDHNGEVWSV------------SWNLTGTILSSAGDDGKV 328 + + N VE H+ ++ S+ WN + +++ + + Sbjct: 307 SVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFF 366 Query: 329 RLWKATYS 336 R++ Sbjct: 367 RMFDRNTK 374 >4J0X-A nrPDB Length = 451 Score = 50.4 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 47/349 (13%), Positives = 105/349 (30%), Gaps = 42/349 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + V G++V T D+ + V+ + + + ++++ + Sbjct: 112 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVK--VIPTKDRRGEVLSLAFRKN 169 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 ++ AS + D ++ + + ++++L L + + + Sbjct: 170 SD-QLYASCA-DFKIRTYSIN---------QFSQLEILYGHHDIVEDISALAMER--CVT 216 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLS--IPPANHLQSDFCLSWCPSRFSPEKLA 184 D L+ + + L K+L + D + + +P Sbjct: 217 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFC 276 Query: 185 VSALEQAIIY---------QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGC 235 +++ + G +A K P I P +G Sbjct: 277 EGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAH-GILP---EPSFNDISGE 332 Query: 236 KDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 295 D +R ++ K +T+ S ++ G + + + E Sbjct: 333 TDEELRKRQLQGKKLLQPFW--ITSLYAIPYS---NVFISGSWSGSLKVWKISDNLRSFE 387 Query: 296 LLSEHDDHNGEVWSVSWNLTGT-------ILSSAGDDGKVRLWKATYSN 337 LL E G V + +G IL+S + ++ W A S Sbjct: 388 LLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIANVSG 436 Score = 35.4 bits (79), Expect = 0.042, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 42/128 (32%), Gaps = 6/128 (4%) Query: 205 AAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMF 264 GH I +++ +P G++ + TG +D ++ ++ + Sbjct: 107 ENTTEGHYDEILTVAASPD-GKY---VVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVL 162 Query: 265 DNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGD 324 + + D S ++ + + + + H+ V +S ++ Sbjct: 163 SLAFRKNSDQLYASCADFKIRTYSINQFSQLEILY--GHHDIVEDISALAMERCVTVGAR 220 Query: 325 DGKVRLWK 332 D LWK Sbjct: 221 DRTAMLWK 228 Score = 33.1 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 14/112 (12%), Positives = 38/112 (33%), Gaps = 11/112 (9%) Query: 220 WAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSD 279 + P + ++ ++ + R+F T ++ +T+ + Sbjct: 41 FQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIP 100 Query: 280 SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++ E + H E+ +V+ + G + + G D K+ +W Sbjct: 101 TSKHEYENTT-----------EGHYDEILTVAASPDGKYVVTGGRDRKLIVW 141 >5WLC-SG nrPDB Length = 573 Score = 50.4 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 47/349 (13%), Positives = 105/349 (30%), Gaps = 42/349 (12%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 66 GH D + V G++V T D+ + V+ + + + ++++ + Sbjct: 234 GHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVK--VIPTKDRRGEVLSLAFRKN 291 Query: 67 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLA 126 ++ AS + D ++ + + ++++L L + + + Sbjct: 292 SD-QLYASCA-DFKIRTYSIN---------QFSQLEILYGHHDIVEDISALAMER--CVT 338 Query: 127 CLGNDGILRLYDALEPSDLRSWTLTSEMKVLS--IPPANHLQSDFCLSWCPSRFSPEKLA 184 D L+ + + L K+L + D + + +P Sbjct: 339 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFC 398 Query: 185 VSALEQAIIY---------QRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGC 235 +++ + G +A K P I P +G Sbjct: 399 EGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAH-GILP---EPSFNDISGE 454 Query: 236 KDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVE 295 D +R ++ K +T+ S ++ G + + + E Sbjct: 455 TDEELRKRQLQGKKLLQPFW--ITSLYAIPYS---NVFISGSWSGSLKVWKISDNLRSFE 509 Query: 296 LLSEHDDHNGEVWSVSWNLTGT-------ILSSAGDDGKVRLWKATYSN 337 LL E G V + +G IL+S + ++ W A S Sbjct: 510 LLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIANVSG 558 Score = 35.0 bits (78), Expect = 0.045, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 42/128 (32%), Gaps = 6/128 (4%) Query: 205 AAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMF 264 GH I +++ +P G++ + TG +D ++ ++ + Sbjct: 229 ENTTEGHYDEILTVAASPD-GKY---VVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVL 284 Query: 265 DNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGD 324 + + D S ++ + + + + H+ V +S ++ Sbjct: 285 SLAFRKNSDQLYASCADFKIRTYSINQFSQLEILY--GHHDIVEDISALAMERCVTVGAR 342 Query: 325 DGKVRLWK 332 D LWK Sbjct: 343 DRTAMLWK 350 Score = 33.1 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 14/112 (12%), Positives = 38/112 (33%), Gaps = 11/112 (9%) Query: 220 WAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSD 279 + P + ++ ++ + R+F T ++ +T+ + Sbjct: 163 FQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIP 222 Query: 280 SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 ++ E + H E+ +V+ + G + + G D K+ +W Sbjct: 223 TSKHEYENTT-----------EGHYDEILTVAASPDGKYVVTGGRDRKLIVW 263 >5TF2-A nrPDB Length = 407 Score = 48.9 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 83/238 (34%), Gaps = 52/238 (21%) Query: 15 VVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIAS 74 V ++ +AT +D +++V+K+ + E ++AH+ I + + + Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKV----PSLEKVLEFKAHEGEIEDLALGPDGK---LVT 230 Query: 75 ASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGIL 134 D +W++D + + W + F+ + G Sbjct: 231 VGRDLKASVWQKD---QLVTQLHWQE-----------NGPTFSSTPYRYQACRFG----- 271 Query: 135 RLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIY 194 ++ D +P+ LR +T+ K L PP + +W S F P + E Sbjct: 272 QVPD--QPAGLRLFTVQIPHKRLRQPPP-----CYLTAWDGSNFLPLRTKSCGHEVVSCL 324 Query: 195 QRGKDG------------KLHVAAKL-------PGHKSLIRSISWAPSIGRWYQLIAT 233 + G +++A L H ++ +++ P GR +L+ + Sbjct: 325 DVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGS 382 Score = 31.5 bits (69), Expect = 0.51, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 26/81 (32%), Gaps = 1/81 (1%) Query: 229 QLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 288 L+ATG DG +R++K+ L + D + GR + + Sbjct: 185 TLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKAS-VWQKD 243 Query: 289 QSNLQVELLSEHDDHNGEVWS 309 Q Q+ + + Sbjct: 244 QLVTQLHWQENGPTFSSTPYR 264 Score = 30.0 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 11/23 (47%), Positives = 16/23 (69%) Query: 310 VSWNLTGTILSSAGDDGKVRLWK 332 V +N T+L++ G DG VR+WK Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWK 200 >1PI6-A nrPDB Length = 615 Score = 48.5 bits (113), Expect = 4e-06, Method: Composition-based stats. Identities = 45/283 (15%), Positives = 100/283 (35%), Gaps = 42/283 (14%) Query: 6 SGHDDLVHDVVYDFYGR-HVATCSSDQHIKVFKLDKDTSNWELSDSWRAHD---SSIVAI 61 SGH ++ T D + + ++ S S R H S + + Sbjct: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSV----VFYQGPPFKFSASDRTHHKQGSFVRDV 212 Query: 62 DWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 +++ P+ G + + D+ + ++ G+ L + D + + FA + L Sbjct: 213 EFS-PDSGEFVITVGSDRKISCFD---------GKSGEFLKYIEDDQEPVQGGIFALSWL 262 Query: 122 GLK-LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 180 + A +G D +R++D ++ WTL + Q + + + Sbjct: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ--------QLGNQQVGVV----ATGNG 310 Query: 181 EKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 240 +++S Y+ G D L + GH I +++ P I +G DGRI Sbjct: 311 RIISLSLDGTLNFYELGHDEVLK---TISGHNKGITALTVNPLI--------SGSYDGRI 359 Query: 241 RIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTE 283 + + ++ +++ + + D + + T+ Sbjct: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITK 402 Score = 42.7 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 95/308 (30%), Gaps = 35/308 (11%) Query: 51 WRAHDSSI-VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKG 109 + H SS+ + ++ + + + S V +W D+E S K G Sbjct: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVK-SEFQVLAG 117 Query: 110 SLYSVKFAPAHLGLKLACLGND--GILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQS 167 + + + L + G D G+ +D + S +V + H Q Sbjct: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWD----------SGNSLGEV-----SGHSQR 162 Query: 168 DFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHK--SLIRSISWAPSIG 225 SR + V + YQ A+ HK S +R + ++P G Sbjct: 163 INACHLKQSR-PMRSMTVGDDGSVVFYQ--GPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 Query: 226 RWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNS---ADVDMDAQGRSDSNT 282 + + T D +I F E+ + D A +D+ Sbjct: 220 EF---VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 Query: 283 EEKAELQSNL-QVELLSEHDDHNGEVWSVSWNLTGT-ILSSAGDDGKVRLWKATYSNEFK 340 S Q L + N +V V+ TG + S DG + ++ + K Sbjct: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVA---TGNGRIISLSLDGTLNFYELGHDEVLK 333 Query: 341 CMSVITAQ 348 +S Sbjct: 334 TISGHNKG 341 >5WLC-LN nrPDB Length = 776 Score = 47.3 bits (110), Expect = 9e-06, Method: Composition-based stats. Identities = 44/297 (14%), Positives = 96/297 (32%), Gaps = 25/297 (8%) Query: 11 LVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGR 70 LV V+Y +A+ S IK + L+ S++AHD+ ++ + + Sbjct: 240 LVWSVIYLPRTDQIASGDSTGSIKFWDF----QFATLNQSFKAHDADVLCLT--TDTDNN 293 Query: 71 IIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGN 130 + SA D+ + + ++ ++ + RW + ++ + L G Sbjct: 294 YVFSAGVDRKIFQFSQNTNKSQ-KNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGV 352 Query: 131 DGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQ 190 + L + S+ + ++ S + + +SW S Sbjct: 353 EKTLVINSLTSFSNGN-YRKMPTVEPYSKNVLVNKEQRLVVSWSESTVK----------- 400 Query: 191 AIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLS 250 I+ G D KL +L + + + + ++F L Sbjct: 401 --IWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFH----LQ 454 Query: 251 PLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEV 307 P+ ++ +T + + +S + V+L SE D+ EV Sbjct: 455 PVGNKLKVTKLDNDLLLRTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEKPQEV 511 Score = 33.1 bits (73), Expect = 0.17, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 68/233 (29%), Gaps = 21/233 (9%) Query: 109 GSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSD 168 ++ S+ F+ + + LRL ++ W + + +S Sbjct: 44 ATITSLAFS-HKSNINKLTPSD---LRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSI 99 Query: 169 FCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRS-ISWAPSIGRW 227 L W +L + + +A LP S + W+ SI Sbjct: 100 EGLCWSNVNGESLRLFSIGGSTVV-------TEWDLATGLPLRNYDCNSGVIWSISINDS 152 Query: 228 YQLIATGCKDGRIRIFKITEKLSPLASEESL----TNSNMFDNSADVDMDAQGRSD---- 279 ++ GC +G + + I+ L + L D + Sbjct: 153 QDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRI 212 Query: 280 -SNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 331 S + + L + + + VWSV + ++S G ++ W Sbjct: 213 WSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFW 265 >5MC6-j nrPDB Length = 397 Score = 45.8 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 58/319 (18%), Positives = 100/319 (31%), Gaps = 52/319 (16%) Query: 52 RAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSL 111 +AHD+ I ++ S S D +K+W+ E +K + K L Sbjct: 13 KAHDADIFSV----SACNSFTVSCSGDGYLKVWDNKLLDNE---NPKDKSYSHFVHKSGL 65 Query: 112 YSVKFAPAHLG-----LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQ 166 + V A +A G L Y + + + S + Sbjct: 66 HHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKH--- 122 Query: 167 SDFCLSWCPSR---FSPEKLAVSALEQAIIYQR------------GKDGKLHVAAKLPGH 211 S + L W S S +A I++ L + + Sbjct: 123 SFWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVE-- 180 Query: 212 KSLIRSISWAPSIGRWYQ-LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADV 270 S + +A S+ + LIATG +G ++I +++ E + N ++ V Sbjct: 181 -SPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSV 239 Query: 271 DMDAQGRSDSNTEEKAELQS------------------NLQVELLSEHDDHNGEVWSVSW 312 QG + + + H+ V S+S+ Sbjct: 240 KFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSF 299 Query: 313 NLTGTILSSAGDDGKVRLW 331 N +G L SAG DGK+R W Sbjct: 300 NDSGETLCSAGWDGKLRFW 318 Score = 36.5 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 38/261 (14%), Positives = 82/261 (31%), Gaps = 37/261 (14%) Query: 23 HVATCSSDQHIKVFKLDKDTSNWE--------LSDSWRAHDSSIVAIDWASPE---YGRI 71 VAT S + +++ ++ + L + H A+ W + Sbjct: 83 LVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHS--FWALKWGASNDRLLSHR 140 Query: 72 IASASYDKTVKLWEEDP--DQEECSGRRWNKLCTLNDS-KGSLYSVKFAPA----HLGLK 124 + + T +W+ P D+ W+ L + + + +FA + G Sbjct: 141 LVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERG-L 199 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLA 184 +A N+G +++ + L ++ M I +N ++S Sbjct: 200 IATGFNNGTVQISELSTLRPLYNFESQHSM----INNSNSIRSVKFSPQGSLLAIAHDSN 255 Query: 185 VSALEQAIIYQRGKD-GKLHVAAKLP-------GHKSLIRSISWAPSIGRWYQLIATGCK 236 + G+ G L V H S + S+S+ S + + + Sbjct: 256 SFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDS----GETLCSAGW 311 Query: 237 DGRIRIFKITEKLSPLASEES 257 DG++R + + K Sbjct: 312 DGKLRFWDVKTKERITTLNMH 332 Score = 33.1 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 6/52 (11%), Positives = 16/52 (30%), Gaps = 4/52 (7%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI 58 H V + ++ G + + D ++ + + + H I Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKER----ITTLNMHCDDI 336 >5AMS-A nrPDB Length = 431 Score = 45.4 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 40/326 (12%), Positives = 97/326 (29%), Gaps = 53/326 (16%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H D V + + V T D ++ + + + + S+++ + S Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPP--KFAGTLTGYGESVISCSFTS-- 119 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH--LGLKL 125 G + +A V + + G +W L + + + H + Sbjct: 120 EGGFLVTADMSGKVLV-----HMGQKGGAQWK----LASQMQEVEEIVWLKTHPTIARTF 170 Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 A DG + Y E ++ + Sbjct: 171 AFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDC-------------------------- 204 Query: 186 SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKI 245 ++ + I +G++ V L ++W G+ I G + Sbjct: 205 -SMGEFINTDKGENTLELVTCSLDS-----TIVAWNCFTGQQLFKITQAEIKGLEAPWIS 258 Query: 246 TEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNG 305 LA E ++ + + +N L + ++++ E D+ + Sbjct: 259 LS----LAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKP--EQDELDA 312 Query: 306 EVWSVSWNLTGTILSSAGDDGKVRLW 331 + S+SW+ ++++ G++ L+ Sbjct: 313 SIESISWSSKFSLMAIGLVCGEILLY 338 Score = 39.2 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 31/195 (15%), Positives = 56/195 (28%), Gaps = 23/195 (11%) Query: 6 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 +G+ + V + G + T + V K + W+L+ + + + Sbjct: 106 TGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKT--H 163 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG--- 122 P R A + D +V W Q +L + + +F G Sbjct: 164 PTIARTFAFGATDGSV--W---CYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 Query: 123 LKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEK 182 L+L D + ++ L T +E+K L P W +PE Sbjct: 219 LELVTCSLDSTIVAWNCFTGQQLFKIT-QAEIKGLEAP------------WISLSLAPET 265 Query: 183 LAVSALEQAIIYQRG 197 L Sbjct: 266 LTKGNSGVVACGSNN 280 Score = 30.8 bits (67), Expect = 0.88, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 35/86 (40%), Gaps = 4/86 (4%) Query: 250 SPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVEL----LSEHDDHNG 305 E + DV +D +G +D + E + + L+V++ L+ D H Sbjct: 7 FITTEEVEQEIVPTVEVEQDVPVDIEGENDDDDEMMNDDEEALEVDMSNNSLTYFDKHTD 66 Query: 306 EVWSVSWNLTGTILSSAGDDGKVRLW 331 V+++ + ++ + G D LW Sbjct: 67 SVFAIGHHPNLPLVCTGGGDNLAHLW 92 >5WLC-LH nrPDB Length = 896 Score = 43.1 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 37/351 (10%), Positives = 109/351 (31%), Gaps = 49/351 (13%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNW----------ELSDSWRAHDSS 57 H D V + + G ++ + ++ + +++L+ ++ + + + S Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYS 355 Query: 58 I---VAIDWASPEYGRIIASASYDKTVKLWEEDP---DQEECSGRRWNKLCTLNDSKGSL 111 + + + ++ +Y ++ +AS D T KL P + + S+ Sbjct: 356 LILQMTENNSNSDYQFLLLNAS-DLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSI 414 Query: 112 YSVKFAPAHLGLKLA-CLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFC 170 S+ + KL D + +L + S +++ + + Sbjct: 415 TSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLY-FPHISAVQIFDFYKNEQVNYQYL 473 Query: 171 LSWCPSRFSPEKLAVSALEQAII-YQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQ 229 S + + ++ + I + KDG+ + ++ + P+ + Sbjct: 474 TSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIE----------YPPNDLLSSK 523 Query: 230 LIATGCKDGRIRIFKITE-----KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNT-- 282 + ++ + + L + + + Sbjct: 524 DLT-----HILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADN 578 Query: 283 ------EEKAELQSNLQVELLSEHD-DHNGEVWSVSWNLTGTILSSAGDDG 326 +SN ++ +S + +H S++W+ G+++ DD Sbjct: 579 NGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK 629 >4FHN-A nrPDB Length = 394 Score = 41.2 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 29/193 (15%), Positives = 63/193 (32%), Gaps = 20/193 (10%) Query: 24 VATCSSDQHIKVFKLDKDTS-NWELSDSWRAHDSSIVAIDWA------SPEYGRIIASAS 76 +A D +++ +T + H + + ID A + ++IAS Sbjct: 105 LACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASVG 164 Query: 77 YDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRL 136 D T+ +W + +G SV+F P++ +L +G +R+ Sbjct: 165 DDCTLIIWRLTDEGPILAGYPL---------SSPGISVQFRPSNPN-QLIVGERNGNIRI 214 Query: 137 YDALEPSDLRSWTLTSEMKVLSIPPANHL---QSDFCLSWCPSRFSPEKLAVSALEQAII 193 +D + T +K + N L + S + + + Sbjct: 215 FDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRWIGSDGSGILAM 274 Query: 194 YQRGKDGKLHVAA 206 + G + ++ A Sbjct: 275 CKSGAWLRWNLFA 287 >3EI3-B nrPDB Length = 383 Score = 41.2 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 47/122 (38%), Gaps = 15/122 (12%) Query: 54 HDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS 113 H + + ++ +P ++A++S D TVKLW+ +++ N + + + Sbjct: 203 HKAKVTHAEF-NPRCDWLMATSSVDATVKLWDLRNIKDK------NSYIAEMPHEKPVNA 255 Query: 114 VKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 173 F P KL +R+Y + + W+ ++ + HL +W Sbjct: 256 AYFNPTD-STKLLTTDQRNEIRVYSSYD------WSKPDQIIIHPHRQFQHLTPIKA-TW 307 Query: 174 CP 175 P Sbjct: 308 HP 309 Score = 32.3 bits (71), Expect = 0.31, Method: Composition-based stats. Identities = 42/324 (12%), Positives = 92/324 (28%), Gaps = 45/324 (13%) Query: 45 WELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQ-----------EEC 93 ++L + D + +++W P + +A S + LW+ D + Sbjct: 63 YKLHRTASPFDRRVTSLEW-HPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAI 121 Query: 94 SGRRWNKL-------------CTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDAL 140 +G ++N+ TL D GS+ V FA C + + R A Sbjct: 122 TGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQV-FAKTDSWDYWYCCVDVSVSRQMLAT 180 Query: 141 EPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDG 200 S R L + + H + P R S ++ Sbjct: 181 GDSTGRLLLLGLDGHEI-FKEKLHKAKVTHAEFNP-RCDWLMATSSVDATVKLWDLRNIK 238 Query: 201 KLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTN 260 + H+ + + + P+ + T + IR++ + P Sbjct: 239 DKNSYIAEMPHEKPVNAAYFNPT---DSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHR 295 Query: 261 SNMFDNSADVDMDAQGR---SDSNTEEKAELQSNLQVELL----------SEHDDHNGEV 307 + +++ L +++ + G + Sbjct: 296 QFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGII 355 Query: 308 WSVSWNLTGTILSSAGDDGKVRLW 331 ++ TG +L+S + +W Sbjct: 356 SLNKFSPTGDVLASGMGFN-ILIW 378 >4AV8-A nrPDB Length = 339 Score = 40.4 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 58/158 (36%), Gaps = 8/158 (5%) Query: 3 PFDSGHDDLVHDVVYDFYGRHVATCSSDQH-IKVFKLDKDTSNWELSDSWRAHDSSIVAI 61 H + V V + G VATCS D I+VF+ D E +SI+ + Sbjct: 173 VLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLD--RTSIIDM 230 Query: 62 DWASPEYGRIIASASYDKTVKLWEE--DPDQEECSGRRWNKLCTLNDSKGSLY-SVKFAP 118 W+ G +A S T+ ++E D + + + W + +K + Sbjct: 231 RWSPD--GSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSK 288 Query: 119 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKV 156 K+A + + G++ ++ +D + V Sbjct: 289 GSNDCKIAWISDTGLVIVWPNRRLADTFKLNYNDDEHV 326 >6IYY-A nrPDB Length = 317 Score = 37.3 bits (84), Expect = 0.010, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 37/87 (42%), Gaps = 5/87 (5%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQH-IKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 H+ ++ + + G +AT S I++F EL +A ++I I++ Sbjct: 174 AHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQA--ANIYCINF-- 229 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEE 92 + +I +S TV ++ + + + Sbjct: 230 NQDASLICVSSDHGTVHIFAAEDPKSK 256 >5M89-A nrPDB Length = 329 Score = 37.3 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 42/218 (19%), Positives = 69/218 (31%), Gaps = 21/218 (9%) Query: 126 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 185 A G DG L +Y + R+ + + + W + + A Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIG-TAKGWVKVYDAGRESAT 125 Query: 186 SA------------LEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQ---- 229 I+ G D K V L + + R + A + Sbjct: 126 FQTHAGPVTGLAVHPGGRILASVGVD-KSFVFYDLETGERVARGYADAALTTCAFHPDGN 184 Query: 230 LIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQ 289 L A G + G I +F T L S T S + A +++ +L+ Sbjct: 185 LFAAGTQTGHILVF-HTTTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLR 243 Query: 290 SNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGK 327 + + E GEV S+SW+ TG L++ G G Sbjct: 244 KSGAAAAVKEL--QTGEVLSISWDYTGQYLATGGGTGV 279 Score = 29.2 bits (63), Expect = 2.4, Method: Composition-based stats. Identities = 21/153 (13%), Positives = 48/153 (31%), Gaps = 18/153 (11%) Query: 8 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 67 H V + GR +A+ D+ + L+ D+++ + Sbjct: 129 HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA-----DAALTTCAFHPD- 182 Query: 68 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 127 G + A+ + + ++ ++ S + L S+ + FA A Sbjct: 183 -GNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFW---FA--------AT 230 Query: 128 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP 160 + ++D + + +VLSI Sbjct: 231 GKGTSSVTIFDLRKSGAAAAVKELQTGEVLSIS 263 >2VDU-B nrPDB Length = 450 Score = 36.1 bits (81), Expect = 0.022, Method: Composition-based stats. Identities = 39/306 (12%), Positives = 90/306 (29%), Gaps = 46/306 (15%) Query: 16 VYDFYGRHVATCSSDQHIKVFKLDKDTSNWEL---------SDSWRAHDSSIVAIDWASP 66 + ++ D + + D + ++ + H S + + Sbjct: 147 CFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKD 206 Query: 67 EYG-RIIASASYDKTVKLWEEDPDQEEC-SGRRWNKLCTLNDSKGSLYSVKFAPAHLGLK 124 G + I ++ D+ +K+ +C +W L K + S+ Sbjct: 207 SDGHQFIITSDRDEHIKI----SHYPQCFIVDKW-----LFGHKHFVSSICCGKD---YL 254 Query: 125 LACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF--SPEK 182 L G D + +D +L ++ S +K HL P RF Sbjct: 255 LLSAGGDDKIFAWDWKTGKNLSTFDYNSLIK--PYLNDQHL--------APPRFQNENND 304 Query: 183 LAVSALEQAIIYQRGKDGKLHVAAK-----LPGHKSLIRSISWAPSIGRWYQLIATGCKD 237 + A+ + I + V A L + ++ I Y +I+ + Sbjct: 305 IIEFAVSKIIKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISLSAHN 364 Query: 238 GRIRIFKITEKLSPLAS------EESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSN 291 ++ ++ S + E +L ++ N+ + S + + Sbjct: 365 DEFQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNLVTKK 424 Query: 292 LQVELL 297 ++ L Sbjct: 425 EEIYPL 430 >5WLC-LW nrPDB Length = 554 Score = 35.4 bits (79), Expect = 0.034, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 17/29 (58%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDK 40 V+ + D G ++AT +D+ +K++ + Sbjct: 277 VNSIAIDRSGYYMATTGADRSMKIWDIRN 305 Score = 35.4 bits (79), Expect = 0.039, Method: Composition-based stats. Identities = 19/133 (14%), Positives = 47/133 (35%), Gaps = 9/133 (6%) Query: 199 DGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESL 258 D + +L H R + + P ++ L+ T + G ++ ++ Sbjct: 178 DHEGTELHRLKQHIE-ARHLDFLP----YHYLLVTAGETGWLKYHDVSTGQLVSELRTKA 232 Query: 259 TNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTI 318 + + + G S+ + E L + G V S++ + +G Sbjct: 233 GPTMAMAQNPWNAVMHLGHSNGTVSLWSPSM----PEPLVKLLSARGPVNSIAIDRSGYY 288 Query: 319 LSSAGDDGKVRLW 331 +++ G D +++W Sbjct: 289 MATTGADRSMKIW 301 >6CVZ-A nrPDB Length = 351 Score = 35.4 bits (79), Expect = 0.038, Method: Composition-based stats. Identities = 22/146 (15%), Positives = 48/146 (32%), Gaps = 18/146 (12%) Query: 54 HDSSIVAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYS 113 H I + ++S G ++ SAS D T+KL + + + ++S Sbjct: 73 HGKQIRGLAFSSYLRG-LLLSASLDNTIKLTSLETNTVVQTYNAG----------RPVWS 121 Query: 114 VKFAPAHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSW 173 + A +G + +YD S + + + + + + Sbjct: 122 CCWCLDEANYIYA-GLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS------YMPRA 174 Query: 174 CPSRFSPEKLAVSALEQAIIYQRGKD 199 + F + LE A +++ D Sbjct: 175 ASAAFPYGGVLAGTLEDASFWEQKMD 200 >5LTD-A nrPDB Length = 525 Score = 35.0 bits (78), Expect = 0.053, Method: Composition-based stats. Identities = 16/116 (13%), Positives = 44/116 (37%), Gaps = 6/116 (5%) Query: 7 GHDDLVHDVVYDFYGRHVATCSSDQH-IKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 65 H + + G +AT S I+VF + ++ + + I ++ ++ Sbjct: 220 AHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRG--TYPTKIYSLAFSP 277 Query: 66 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL 121 + ++S +TV ++ ++ + + NK L ++ ++ +P Sbjct: 278 DNR--FVIASSATETVHIFRLGEEEAANTIKSANKKARLTKAQVP-NPLETSPDIY 330 >5CWW-B nrPDB Length = 595 Score = 33.4 bits (74), Expect = 0.13, Method: Composition-based stats. Identities = 26/155 (16%), Positives = 50/155 (32%), Gaps = 22/155 (14%) Query: 102 CTLNDSKGSLYSVKFAPAHL-GLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIP 160 T S+ ++ S + P + G L + D I+R+++ S WT + + + Sbjct: 166 TTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWEL---STADRWTFDAPTLAIDLK 222 Query: 161 P---ANHLQSDFCLS-------WCPSRFSPEKLA-------VSALEQAIIYQRGKDGKLH 203 A +L DF +S + P F E A ++ G ++ Sbjct: 223 KLADATYLDQDFGVSTSATNKGFSPDAFDMEVAAACFPTRDSGGWAPMTLWLAMTSGDVY 282 Query: 204 VAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 238 L + + PS+ +D Sbjct: 283 ALCPLLP-QRWTPPPTLIPSLSASIVAKVAAAEDN 316 >2I3T-A nrPDB Length = 341 Score = 33.4 bits (74), Expect = 0.15, Method: Composition-based stats. Identities = 26/208 (12%), Positives = 59/208 (28%), Gaps = 13/208 (6%) Query: 19 FYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYD 78 + + S D I+V + ++++ + + + + Sbjct: 110 YGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNN 169 Query: 79 KTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRL-- 136 V+ W P E+ +G + K + V P AC DG + + Sbjct: 170 SQVQ-WFRLPLCEDDNGTIEE-----SGLKYQIRDVALLPKEQ-EGYACSSIDGRVAVEF 222 Query: 137 YDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQR 196 +D S L++ N + + P + + Sbjct: 223 FDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSP--RHKFLYTAGSDGIISCWNL 280 Query: 197 GKDGKLHVAAKLPGHKSLIRSISWAPSI 224 K+ AK ++ + I+ + +I Sbjct: 281 QTRKKIKNFAKF--NEDSVVKIACSDNI 306 Score = 30.0 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 30/71 (42%), Gaps = 7/71 (9%) Query: 12 VHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRI 71 V+ + + + + T SD I + L ++ + + ++ S+V I + I Sbjct: 254 VNSIEFSPRHKFLYTAGSDGIISCWNLQTRK---KIKNFAKFNEDSVVKIACS----DNI 306 Query: 72 IASASYDKTVK 82 + A+ D T K Sbjct: 307 LCLATSDDTFK 317 >1XFK-A nrPDB Length = 336 Score = 30.8 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 26/96 (27%), Gaps = 1/96 (1%) Query: 216 RSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQ 275 I+WA G +ATG K RI I E L + + Sbjct: 127 HEIAWATFQGLAQHFLATGVKQPRIGIINFDAHFDLRTFESELAPVRPSSGTPFNQIHHF 186 Query: 276 GRSDSNTEEKAELQSNLQVELLSEHD-DHNGEVWSV 310 + A L + + + VW V Sbjct: 187 CQQQGWDFHYACLGVSRASNTPALFERADKLGVWYV 222 >6N8P-A nrPDB Length = 979 Score = 30.4 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 43/300 (14%), Positives = 84/300 (28%), Gaps = 49/300 (16%) Query: 17 YDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHD----SSIVAIDWASPEYGRII 72 + GR + +C SD + + + E S + +I I W + G Sbjct: 227 WQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPF 286 Query: 73 ASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDG 132 T+ ++ C G + F +G + + Sbjct: 287 -------TI------FQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEAD-- 331 Query: 133 ILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI 192 A D + + +E +++ I W P + LA Sbjct: 332 -----PAATFDDPYALVVLAEEELVVIDLQ-------TAGWPPVQL--PYLASLHCSAIT 377 Query: 193 IYQRGKDGKLHVAAKLPGHKSLIR----SISWAPSIGRWYQ-------LIATGCKDGRIR 241 + L + ++ S ++ W G L+ TG +DG +R Sbjct: 378 CSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVR 437 Query: 242 IFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHD 301 + + L + S + D + + AQG E L+ + S+ Sbjct: 438 FWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGED-----EWPPLRKVGSFDPYSDDP 492 >3ZYZ-A nrPDB Length = 713 Score = 27.7 bits (59), Expect = 7.1, Method: Composition-based stats. Identities = 17/114 (14%), Positives = 32/114 (28%), Gaps = 3/114 (2%) Query: 80 TVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILR--LY 137 +W P QE + ++ S +Y++ +P ++ G+D Sbjct: 498 KAVVWAGLPSQESGNALVDVLWGDVSPSGKLVYTIAKSPNDYNTRIVSGGSDSFSEGLFI 557 Query: 138 DALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQA 191 D D LS N+ + LS S + + Sbjct: 558 DYKHFDDANITPRYEFGYGLSYTKFNYSR-LSVLSTAKSGPATGAVVPGGPSDL 610 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.106 0.276 Lambda K H 0.267 0.0325 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,649,047 Number of Sequences: 36641 Number of extensions: 413162 Number of successful extensions: 3976 Number of sequences better than 10.0: 141 Number of HSP's better than 10.0 without gapping: 199 Number of HSP's successfully gapped in prelim test: 61 Number of HSP's that attempted gapping in prelim test: 1225 Number of HSP's gapped (non-prelim): 1040 length of query: 349 length of database: 10,336,785 effective HSP length: 98 effective length of query: 251 effective length of database: 6,745,967 effective search space: 1693237717 effective search space used: 1693237717 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.7 bits)