BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P52839 (326 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1Q44-A nrPDB 667 0.0 5MEK-A nrPDB 225 2e-59 2REO-A nrPDB 140 7e-34 3BFX-A nrPDB 121 3e-28 2GWH-A nrPDB 121 4e-28 4JVN-A nrPDB 119 1e-27 2Z5F-A nrPDB 118 4e-27 3U3O-A nrPDB 117 7e-27 1CJM-A nrPDB 117 1e-26 2ZVQ-X nrPDB 114 5e-26 1AQU-A nrPDB 113 1e-25 1OV4-A nrPDB 111 5e-25 5X2B-D nrPDB 109 1e-24 1Q22-A nrPDB 103 9e-23 1Q1Q-A nrPDB 103 1e-22 1ZD1-A nrPDB 100 1e-21 1X8L-A nrPDB 85 4e-17 4EEC-A nrPDB 54 8e-08 3NIB-A nrPDB 53 2e-07 3MGC-A nrPDB 49 4e-06 5NFR-A nrPDB 35 0.044 3IBD-A nrPDB 31 0.81 5PAL-A nrPDB 31 0.92 3EC6-A nrPDB 30 1.4 5INR-A nrPDB 30 2.0 1Y0Y-A nrPDB 29 2.4 5ZGM-A nrPDB 29 2.5 1XMD-A nrPDB 28 7.0 3TPL-A nrPDB 27 9.4 >1Q44-A nrPDB Length = 326 Score = 667 bits (1721), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKR 60 MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKR Sbjct: 1 MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKR 60 Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY 120 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY Sbjct: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY 120 Query: 121 YESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAP 180 YESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAP Sbjct: 121 YESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAP 180 Query: 181 EETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMK 240 EETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMK Sbjct: 181 EETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMK 240 Query: 241 RIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDT 300 RIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDT Sbjct: 241 RIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDT 300 Query: 301 LSESLAEEIDRTIEEKFKGSGLKFSS 326 LSESLAEEIDRTIEEKFKGSGLKFSS Sbjct: 301 LSESLAEEIDRTIEEKFKGSGLKFSS 326 >5MEK-A nrPDB Length = 322 Score = 225 bits (574), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 128/309 (41%), Positives = 183/309 (59%), Gaps = 12/309 (3%) Query: 23 LISSLPKEKGWLVSE-IYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWL 81 LIS+ P EKGW E + E+ G W ++L+G + Q+ F+A+ SD ++ + PK+GTTWL Sbjct: 15 LISTFPHEKGWRPKEPLIEYGGYWWLPSLLEGCIHAQEFFQARPSDFLVCSYPKTGTTWL 74 Query: 82 KALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHI 141 KAL FA+ NR +F SS+ PLL NPH VP++E + P+ D L +THI Sbjct: 75 KALTFAIANRSRFDDSSN---PLLKRNPHEFVPYIEIDFPFFPEVDVLKDKGNTLFSTHI 131 Query: 142 SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFI 201 + LP+SV S CK+VY R PKD F+S+W F K E +E++ + FC G Sbjct: 132 PYELLPDSVVKSGCKMVYIWREPKDTFISMWTFLHKERTELGPVSNLEESFDMFCRGLSG 191 Query: 202 GGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIE----EEEVR 257 GP+ +HIL YW A +ENP+++LF+ YE ++ +K +AEF+ GF + V Sbjct: 192 YGPYLNHILAYWKAYQENPDRILFLKYETMRADPLPYVKSLAEFMGHGFTAEEEEKGVVE 251 Query: 258 EIVKLCSFESLSNLEVNKEGK----LPNGIETKTFFRKGEIGGWRDTLSESLAEEIDRTI 313 ++V LCSFE+L NLE NK K P +FRKG++G W + L+ +A ID + Sbjct: 252 KVVNLCSFETLKNLEANKGEKDREDRPGVYANSAYFRKGKVGDWSNYLTPEMAARIDGLM 311 Query: 314 EEKFKGSGL 322 EEKFKG+GL Sbjct: 312 EEKFKGTGL 320 >2REO-A nrPDB Length = 305 Score = 140 bits (353), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 90/270 (33%), Positives = 146/270 (54%), Gaps = 13/270 (4%) Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY 120 F+AK D+IL T PKSGTTW+ ++ +LN V L + L + F + Sbjct: 43 FQAKPDDLILATYPKSGTTWMHEILDMILNDGD--VEKCKRAQTLDRHAFLELKF---PH 97 Query: 121 YESPDFDFS-SLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLA 179 E PD +F + SP+L+ TH+ +P S+ +CKIVY RNPKD VS +HF ++A Sbjct: 98 KEKPDLEFVLEMSSPQLIKTHLPSHLIPPSIWKENCKIVYVARNPKDCLVSYYHF-HRMA 156 Query: 180 PEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEM 239 +E+ E F GK +GG ++DH+ +W A ++ +++L++ YE++KK + E+ Sbjct: 157 SFMPDPQNLEEFYEKFMSGKVVGGSWFDHVKGWWAA--KDMHRILYLFYEDIKKDPKREI 214 Query: 240 KRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKT---FFRKGEIGG 296 ++I +FLE I EE + +I+ SF+ + + LP I + F RKG G Sbjct: 215 EKILKFLEKD-ISEEILNKIIYHTSFDVMKQNPMTNYTTLPTSIMDHSISPFMRKGMPGD 273 Query: 297 WRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 W++ + + EE D+ ++K GS L F + Sbjct: 274 WKNYFTVAQNEEFDKDYQKKMAGSTLTFRT 303 >3BFX-A nrPDB Length = 296 Score = 121 bits (304), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 75/272 (27%), Positives = 138/272 (50%), Gaps = 20/272 (7%) Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY 120 FEAK D+++ T PK+GTTW++ +V + ++ + H PF+E Sbjct: 35 FEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRA----IIQHRH---PFIEWAR 87 Query: 121 YESPDF--DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGK-- 176 P ++PSPR++ TH+S LP S ++CK +Y RN KD VS +HF + Sbjct: 88 PPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMN 147 Query: 177 KLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTE 236 + P+ E+ E F GK + G ++DH+ +W ++ +++LF+ YE++K+ + Sbjct: 148 HMLPDPGT---WEEYFETFINGKVVWGSWFDHVKGWW--EMKDRHQILFLFYEDIKRDPK 202 Query: 237 VEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGI---ETKTFFRKGE 293 E++++ +F+ ++E + +IV+ SFE + + + I +F RKG Sbjct: 203 HEIRKVMQFMGKK-VDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGT 261 Query: 294 IGGWRDTLSESLAEEIDRTIEEKFKGSGLKFS 325 +G W++ + + E D K +G+ + FS Sbjct: 262 VGDWKNHFTVAQNERFDEIYRRKMEGTSINFS 293 >2GWH-A nrPDB Length = 298 Score = 121 bits (303), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 89/308 (28%), Positives = 151/308 (49%), Gaps = 34/308 (11%) Query: 36 SEIYEFQG-----LWHTQAILQGILICQK-----RFEAKDSDIILVTNPKSGTTWLKALV 85 SE + F G + + + ILQ C F+AK D+++ T PK+GTTW + +V Sbjct: 2 SEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIV 61 Query: 86 FALLNRHKFPVSSSGNHPLLVTNPHLLVPFLE------GVYYESPDFDFSSLPSPRLMNT 139 + N V S P H PFLE G E ++PSPR++ T Sbjct: 62 ELIQNEGD--VEKSKRAPT-----HQRFPFLEMKIPSLGSGLEQA----HAMPSPRILKT 110 Query: 140 HISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGK 199 H+ LP S+ +CKI+Y RNPKD VS +HF +++ A E+ E F GK Sbjct: 111 HLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHF-QRMNKALPAPGTWEEYFETFLAGK 169 Query: 200 FIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREI 259 G + +H+ +W A ++ +++L++ YE++KK + E++++AEF+ ++++ + +I Sbjct: 170 VCWGSWHEHVKGWWEA--KDKHRILYLFYEDMKKNPKHEIQKLAEFIGKK-LDDKVLDKI 226 Query: 260 VKLCSFESLSNLEVNKEGKLPNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEK 316 V SF+ + + +P I + F RKG +G W+ + + E D ++K Sbjct: 227 VHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKK 286 Query: 317 FKGSGLKF 324 + L F Sbjct: 287 MTDTRLTF 294 >4JVN-A nrPDB Length = 294 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 85/278 (30%), Positives = 136/278 (48%), Gaps = 30/278 (10%) Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLE--- 117 F+A+ D+++ T PKSGTTW+ +V+ + ++ N +PFLE Sbjct: 33 FQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKED----VIFN---RIPFLECRK 85 Query: 118 -----GVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLW 172 GV + SPR++ TH+ LP S CKI+Y CRN KD+ VS + Sbjct: 86 ENLMNGVK------QLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFY 139 Query: 173 HFGKKLAPEET-ADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEEL 231 +F +A +P + VE F +G+ G ++ H+ +W + +VLF+ YE+L Sbjct: 140 YFFLMVAGHPNPGSFP--EFVEKFMQGQVPYGSWYKHVKSWWEKGKS--PRVLFLFYEDL 195 Query: 232 KKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKT---F 288 K+ E+ ++ FLE EE V I+ SF+ + N LP+ I + F Sbjct: 196 KEDIRKEVIKLIHFLERK-PSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPF 254 Query: 289 FRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 RKG G W++ +E+L E+ D+ E++ K S LKF + Sbjct: 255 MRKGITGDWKNHFTEALNEKFDKHYEQQMKESTLKFRT 292 >2Z5F-A nrPDB Length = 298 Score = 118 bits (295), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 80/274 (29%), Positives = 135/274 (49%), Gaps = 19/274 (6%) Query: 60 RFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGV 119 +F ++ DI++ T PKSGTTW+ ++ +LN G V + +P L Sbjct: 35 QFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTS 94 Query: 120 YYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFG--KK 177 E PSPR++ TH+ LP+S ++CK++Y RN KD+ VS +HF Sbjct: 95 GIEQ----LEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNN 150 Query: 178 LAPEETADYP--IEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQT 235 L P +P E+ +E F GK G ++ H+ +W E+P +LF+ YE++K+ Sbjct: 151 LQP-----FPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKRKEEHP--ILFLYYEDMKENP 203 Query: 236 EVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKT---FFRKG 292 + E+K+I FLE + +E + I+ SFE + + + LP + + F RKG Sbjct: 204 KEEIKKIIRFLEKN-LNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKG 262 Query: 293 EIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 G W++ + + E+ D E + + L+F + Sbjct: 263 TAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRT 296 >3U3O-A nrPDB Length = 315 Score = 117 bits (293), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 82/284 (28%), Positives = 137/284 (48%), Gaps = 38/284 (13%) Query: 59 KRFEAKDSDIILVTNPKSGTTWLKALVFALLNR------HKFPVSSSGNHPLLVTNPHLL 112 + F+A+ D+++ T PKSGTTW+ ++ + H+ P+ + Sbjct: 52 QSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPI-------------FMR 98 Query: 113 VPFLEGVYYESPDF-----DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDM 167 VPFLE +++P P+PRL+ TH+ LP+++ K+VY RN KD+ Sbjct: 99 VPFLE---FKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDV 155 Query: 168 FVSLWHF--GKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLF 225 VS +HF K+ PE + +E F G+ G ++ H+ E+W SR +P VL+ Sbjct: 156 AVSYYHFYHMAKVHPEPGT---WDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHP--VLY 210 Query: 226 VTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIET 285 + YE++K+ + E+++I EF+ + EE V +V+ SF+ + + +P Sbjct: 211 LFYEDMKENPKREIQKILEFVGHS-LPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMD 269 Query: 286 KT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 + F RKG G W+ T + + E D EK G L F S Sbjct: 270 HSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRS 313 >1CJM-A nrPDB Length = 295 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 134/275 (48%), Gaps = 20/275 (7%) Query: 59 KRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEG 118 + F+A+ D+++ T PKSGTTW+ ++ + + P+ V VPFLE Sbjct: 32 QSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGD--LEKCNRAPIYVR-----VPFLEV 84 Query: 119 VYYESPDF--DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGK 176 P P PRL+ +H+ LP+++ K+VY RNPKD+ VS +HF + Sbjct: 85 NDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHR 144 Query: 177 --KLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQ 234 K PE + +E F G+ G ++ H+ E+W SR +P VL++ YE++K+ Sbjct: 145 MEKAHPEPGT---WDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHP--VLYLFYEDMKEN 199 Query: 235 TEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKT---FFRK 291 + E+++I EF+ + EE + +V+ SF+ + + +P + + F RK Sbjct: 200 PKREIQKILEFVGRS-LPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRK 258 Query: 292 GEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 G G W+ T + + E D EK G L F S Sbjct: 259 GMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRS 293 >2ZVQ-X nrPDB Length = 295 Score = 114 bits (285), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 82/272 (30%), Positives = 139/272 (51%), Gaps = 18/272 (6%) Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVP-FLEGV 119 FEA+ DI++ T PKSGTTW+ ++ + N V L++P GV Sbjct: 34 FEARPDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYKRVPFMELIIPGITNGV 93 Query: 120 YYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGK--K 177 +++PSPR++ TH+ LP S + CKI+Y RN KD+ VS ++F + K Sbjct: 94 EM------LNNMPSPRIVKTHLPVQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAK 147 Query: 178 LAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEV 237 + PE E+ +E F G+ GP++DH+ +W +E ++L++ YE++K+ + Sbjct: 148 IHPEPGT---WEEFLEKFMAGQVSFGPWYDHVKSWWEKRKE--YRILYLFYEDMKENPKC 202 Query: 238 EMKRIAEFLECGFIEEEEVREIVKLCSFESLS-NLEVNKEGKLPNGIE--TKTFFRKGEI 294 E+++I +FLE I EE + +I+ SF + N N + ++ F RKG Sbjct: 203 EIQKILKFLEKD-IPEEILNKILYHSSFSVMKENPSANYTTMMKEEMDHSVSPFMRKGIS 261 Query: 295 GGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 G W++ + + E+ + +K + S LKF S Sbjct: 262 GDWKNQFTVAQYEKFEEDYVKKMEDSTLKFRS 293 >1AQU-A nrPDB Length = 297 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 79/274 (28%), Positives = 132/274 (48%), Gaps = 26/274 (9%) Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLV---PFLE 117 F A+ D+++ T PKSGTTW+ +V+ + V + P+L + Sbjct: 36 FLARPDDLVIATYPKSGTTWISEVVYMIYKEGD--VEKCKEDAIFNRIPYLECRNEDLIN 93 Query: 118 GVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKK 177 G+ SPR++ TH+ LP S +CK++Y CRN KD+ VS ++F Sbjct: 94 GIK------QLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLM 147 Query: 178 LAPEETADYPIEKA----VEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKK 233 + YP K+ VE F +G+ G ++DH+ +W S+ ++VLF+ YE++K+ Sbjct: 148 I-----TSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKN--SRVLFMFYEDMKE 200 Query: 234 QTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKT---FFR 290 E+ ++ EFLE E V I++ SF+ + N +P + + F R Sbjct: 201 DIRREVVKLIEFLERK-PSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMR 259 Query: 291 KGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKF 324 KG IG W++ E+L E D +++ K +KF Sbjct: 260 KGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKF 293 >1OV4-A nrPDB Length = 293 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 85/275 (30%), Positives = 139/275 (50%), Gaps = 42/275 (15%) Query: 57 CQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFL 116 + F +D D+I++T PKSGT WL A + L++ S G+ + + VP Sbjct: 34 VRDEFVIRDEDVIILTYPKSGTNWL-AEILCLMH-------SKGDAKWIQS-----VPIW 80 Query: 117 EGVYYESPDFDFSSLP---SPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWH 173 E + + +++L SPRL ++H+ P+S SS K++Y RNP+D+ VS + Sbjct: 81 ERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYF 140 Query: 174 FGKKL----APEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYE 229 F K + P+ +Y E FC+G + G ++DHI W RE N L ++YE Sbjct: 141 FWKNMKFIKKPKSWEEY-----FEWFCQGTVLYGSWFDHI-HGWMPMREEKN-FLLLSYE 193 Query: 230 ELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNG------- 282 ELK+ T +++I +FL +E EE+ I+K SF+S+ KE K+ N Sbjct: 194 ELKQDTGRTIEKICQFL-GKTLEPEELNLILKNSSFQSM------KENKMSNYSLLSVDY 246 Query: 283 -IETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEK 316 ++ RKG G W++ + + AE+ D+ +EK Sbjct: 247 VVDKTQLLRKGVSGDWKNHFTVAQAEDFDKLFQEK 281 >5X2B-D nrPDB Length = 281 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 140/291 (48%), Gaps = 29/291 (9%) Query: 38 IYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVS 97 ++++ G++ + + +L F+A++ DI LV+ PKSGT WL ++ + P + Sbjct: 3 LHKYMGIFFSTMSSEELLGSLDSFDAREDDIFLVSYPKSGTHWLAEVI------ERIPDA 56 Query: 98 SSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKI 157 + +T+P + + +E + +P R + TH+++ LP +VK CKI Sbjct: 57 G-----ITLTSP---IELGDISKFE----ELKRIPKRRAIPTHLNYEMLPVTVKQKQCKI 104 Query: 158 VYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASR 217 +Y RNPKD VS++H+ + P + +E F +G + G ++DH+L + Sbjct: 105 IYIVRNPKDTAVSMFHYYRD-NPNLPSTETWAAFLELFLKGDVVYGSWFDHVLS--WEEH 161 Query: 218 ENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEG 277 +N VLF+ YEE+KK +K+I FL + + E+ +I + SF + + KE Sbjct: 162 KNDKNVLFIFYEEMKKDFVKSLKKITAFLGID-VNDSEMAKIARSTSFSEMKS-NAAKEN 219 Query: 278 KLPNGI------ETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGL 322 PN + + FRKG +G W + + D EK + S + Sbjct: 220 CDPNHVICALTSDRNLVFRKGVVGDWINYFTPKQNRGFDELFTEKMRNSDV 270 >1Q22-A nrPDB Length = 299 Score = 103 bits (257), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 143/298 (47%), Gaps = 33/298 (11%) Query: 34 LVSEIYEFQGLWHTQAI--LQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNR 91 L E + ++G+ + L+ I + + + +D DI ++T PKSGTTW+ ++ +L Sbjct: 14 LPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKE 73 Query: 92 HKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLP---SPRLMNTHISHLSLPE 148 P + + VP E + SLP SPRLM++H+ + Sbjct: 74 ---------GDPSWIRS----VPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTK 120 Query: 149 SVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDH 208 + SS K++Y RNP+D+ VSL+H+ K + P ++ + F +G+ G ++DH Sbjct: 121 AFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTP-DQFLRDFLKGEVQFGSWFDH 179 Query: 209 ILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGF----IEEEEVREIVKLCS 264 I + W + N LF+TYEEL++ + ++RI CGF + +E + +V + Sbjct: 180 I-KGWLRMKGKDN-FLFITYEELQQDLQGSVERI-----CGFLGRPLGKEALGSVVAHST 232 Query: 265 FESLSNLEVNKEGKLPNGI---ETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKG 319 F ++ ++ LP + F RKG G W++ + + +E DR ++ +G Sbjct: 233 FSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRG 290 >1Q1Q-A nrPDB Length = 350 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 143/298 (47%), Gaps = 33/298 (11%) Query: 34 LVSEIYEFQGLWHTQAI--LQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNR 91 L E + ++G+ + L+ I + + + +D DI ++T PKSGTTW+ ++ +L Sbjct: 12 LPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKE 71 Query: 92 HKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLP---SPRLMNTHISHLSLPE 148 P + + VP E + SLP SPRLM++H+ + Sbjct: 72 ---------GDPSWIRS----VPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTK 118 Query: 149 SVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDH 208 + SS K++Y RNP+D+ VSL+H+ K + P ++ + F +G+ G ++DH Sbjct: 119 AFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTP-DQFLRDFLKGEVQFGSWFDH 177 Query: 209 ILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGF----IEEEEVREIVKLCS 264 I + W + N LF+TYEEL++ + ++RI CGF + +E + +V + Sbjct: 178 I-KGWLRMKGKDN-FLFITYEELQQDLQGSVERI-----CGFLGRPLGKEALGSVVAHST 230 Query: 265 FESLSNLEVNKEGKLPNGI---ETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKG 319 F ++ ++ LP + F RKG G W++ + + +E DR ++ +G Sbjct: 231 FSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRG 288 >1ZD1-A nrPDB Length = 284 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 83/303 (27%), Positives = 141/303 (46%), Gaps = 35/303 (11%) Query: 28 PKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFA 87 P G S+ +EF G+ +G + F + SD+ +VT PKSGT+ L+ +V+ Sbjct: 9 PSTPGEFESKYFEFHGV-RLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSLLQEVVYL 67 Query: 88 LLNRHKFPVSSSGNHP--LLVTNPHLLVPFLEGVYYESPDFDF-SSLPSPRLMNTHISHL 144 + S G P + + N +P LE Y P D L SPRL+ +H+ + Sbjct: 68 V---------SQGADPDEIGLMNIDEQLPVLE---YPQPGLDIIKELTSPRLIKSHLPYR 115 Query: 145 SLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADY--PIEKAVEAFCEGKFIG 202 LP + + K++Y RNPKD+ VS + F + L T Y ++ F K Sbjct: 116 FLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSL---RTMSYRGTFQEFCRRFMNDKLGY 172 Query: 203 GPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKL 262 G +++H+ E+W R + N VLF+ YE++ + ++++A FL ++ ++ + + Sbjct: 173 GSWFEHVQEFW-EHRMDSN-VLFLKYEDMHRDLVTMVEQLARFLGVS-CDKAQLEALTEH 229 Query: 263 CSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGL 322 C L + N E LP G +G +G W+D + S+ E+ D ++K L Sbjct: 230 C--HQLVDQCCNAEA-LPVG--------RGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDL 278 Query: 323 KFS 325 F Sbjct: 279 TFD 281 >1X8L-A nrPDB Length = 351 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 104/201 (51%), Gaps = 20/201 (9%) Query: 135 RLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAV-- 192 R + TH+ LSL + K+VY R+P+D+ VS +H + L Y + K Sbjct: 159 RFVKTHLP-LSLMPPNMLDTVKMVYLARDPRDVAVSSFHHARLL-------YLLNKQSNF 210 Query: 193 ----EAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLEC 248 E F G + P+++H+ E W A R +PN +LF+ YE+ K + RIA+FL Sbjct: 211 KDFWEMFHRGLYTLTPYFEHVKEAW-AKRHDPN-MLFLFYEDYLKDLPGSIARIADFLGK 268 Query: 249 GFIEEEEVREIVKLCSFESL-SNLEVNKEGKLPNGI--ETKTFFRKGEIGGWRDTLSESL 305 + EE+++ + + +FE +N VN E GI + + F RKG+ G WRD E + Sbjct: 269 K-LSEEQIQRLSEHLNFEKFKNNGAVNMEDYREIGILADGEHFIRKGKAGCWRDYFDEEM 327 Query: 306 AEEIDRTIEEKFKGSGLKFSS 326 ++ ++ I++ K + L++ + Sbjct: 328 TKQAEKWIKDNLKDTDLRYPN 348 >4EEC-A nrPDB Length = 286 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 104/240 (43%), Gaps = 41/240 (17%) Query: 70 LVTNPKSGTTWLKALVFALLNRH---KFPVSSSGNHPLLVTNPHLLVPFLEGVYY--ESP 124 + + PK+G WL+ ++ + + +P +G VP LEG+ E+P Sbjct: 23 IASYPKAGGHWLRCMLTSYVTGEPVETWPGIQAG------------VPHLEGLLRDGEAP 70 Query: 125 DFDFSSLPSPR-LMNTHI-SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEE 182 D P + L+ TH + + + S+ K+V RNP+D +SL K + PE+ Sbjct: 71 SAD----PDEQVLLATHFTADRPVLRFYRESTAKVVCLIRNPRDAMLSLMRM-KGIPPED 125 Query: 183 TADYPIEKAVEAFCEGK-------FIGGPFWDHILEYWYASREN--PNK-VLFVTYEELK 232 K E F + + G W + W S PN VL V YE+L+ Sbjct: 126 VE--ACRKIAETFIADEGFSSVRIWAGEGSWPENIRSWTDSVHESFPNAAVLAVRYEDLR 183 Query: 233 KQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKG 292 K E E+ ++ +FLE G + V + V C+ E + +E + KL G+ET +G Sbjct: 184 KDPEGELWKVVDFLELG--GRDGVADAVANCTLERMREME--ERSKL-LGLETTGLMTRG 238 >3NIB-A nrPDB Length = 309 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 113/267 (42%), Gaps = 30/267 (11%) Query: 70 LVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFS 129 + + PK+G TWL+ ++ A + +G P + + LEG+ + D + Sbjct: 41 IASYPKAGNTWLRCMLAAYI---------TGKAPQTWKDMETVSLELEGMLHLG-DMPPT 90 Query: 130 SLPSPRLMNTHI-SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEE------ 182 P L+ TH+ + + + ++ K++Y RNP+D+ +S ++ ++ Sbjct: 91 EPTKPVLVKTHLKADVPVLGLYSEATAKVLYLVRNPRDILLSAMRM-TAISRDDMESSRT 149 Query: 183 -TADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASREN--PN-KVLFVTYEELKKQTEVE 238 D+ + + G G W + W S + PN VL + YE+LK Sbjct: 150 FARDFIANEGLRMRGRGGGAGLGSWPENVRIWTESSRDRFPNADVLTMRYEDLKGDPVAR 209 Query: 239 MKRIAEFLECGF-IEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGE---- 293 I EFL+ G ++ E++R V C+ E + LE K + + T R GE Sbjct: 210 FSEIVEFLDLGDPVDIEDIRRAVAACTLERMRELE--KRSQQQGQWASMTGGRGGEKHPF 267 Query: 294 IGGWRDTLSES-LAEEIDRTIEEKFKG 319 +G R S S L E+I+ +E G Sbjct: 268 VGEGRYDQSLSFLGEDIESAYQELLHG 294 >3MGC-A nrPDB Length = 319 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 52/230 (22%), Positives = 92/230 (40%), Gaps = 43/230 (18%) Query: 70 LVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFS 129 + + PK+G TW++ ++ A + +G P + + LE + F Sbjct: 41 IASYPKAGNTWVRCMLAAYI---------TGKAPQVWNDIDAESLTLEAM------LRFG 85 Query: 130 SLP-----SPRLMNTHI-SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFG--KKLAPE 181 LP P L+ TH+ + + + ++ K++Y RNP+DM +S + E Sbjct: 86 DLPPAEPMEPVLVKTHLKADVPVLGLYGEATAKVLYLVRNPRDMLLSSMRMASISRDDVE 145 Query: 182 ETADYPIEKAVEAFCEGKFIG-----------GPFWDHILEYWYASREN--PN-KVLFVT 227 ++ D+ F + +G W + W S + PN VL + Sbjct: 146 KSRDF-----ARKFIANEGLGWNALGAGGGVGLGSWPENVRSWTESSSDRFPNADVLTMR 200 Query: 228 YEELKKQTEVEMKRIAEFLECGF-IEEEEVREIVKLCSFESLSNLEVNKE 276 YE+LK I EFL+ G ++ E++R V + E + LE E Sbjct: 201 YEDLKGDPVARFSEIVEFLDLGGPVDIEDIRRAVAASTLERMRELEKRSE 250 >5NFR-A nrPDB Length = 320 Score = 35.0 bits (79), Expect = 0.044, Method: Compositional matrix adjust. Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 15/122 (12%) Query: 145 SLPESVKSSSCK-IVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGG 203 S+ ESVK K V C NP D+ V+++H + ++ P EK G Sbjct: 100 SVAESVKLHCSKAFVICVSNPLDIMVNVFH--------KFSNLPHEKICGM--AGILDTS 149 Query: 204 PFWDHILEYWYASRENPNKVLFVTYEEL----KKQTEVEMKRIAEFLECGFIEEEEVREI 259 + I + S E+ N V+ + +L ++ T V ++EF++ I + E++EI Sbjct: 150 RYCSLIADKLKVSAEDVNAVILGGHGDLMVPLQRYTSVNGVPLSEFVKKNMISQNEIQEI 209 Query: 260 VK 261 ++ Sbjct: 210 IQ 211 >3IBD-A nrPDB Length = 476 Score = 30.8 bits (68), Expect = 0.81, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 38/77 (49%), Gaps = 3/77 (3%) Query: 13 DEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVT 72 +E + +E + LI L K KG L+ + FQ + T I+ I + KRF +D + + + Sbjct: 124 EERIQEEAQCLIEELRKSKGALMDPTFLFQSI--TANIICSI-VFGKRFHYQDQEFLKML 180 Query: 73 NPKSGTTWLKALVFALL 89 N T L + VF L Sbjct: 181 NLFYQTFSLISSVFGQL 197 >5PAL-A nrPDB Length = 109 Score = 30.8 bits (68), Expect = 0.92, Method: Compositional matrix adjust. Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 13/66 (19%) Query: 231 LKKQTEVEMKRIAEFLE---CGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKT 287 LK +T+ ++K + E L+ GFIEEEE++ ++K S G+ N ETK Sbjct: 35 LKGKTDAQVKEVFEILDKDQSGFIEEEELKGVLKGFS----------AHGRDLNDTETKA 84 Query: 288 FFRKGE 293 G+ Sbjct: 85 LLAAGD 90 >3EC6-A nrPDB Length = 139 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 5/77 (6%) Query: 149 SVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDH 208 + S KI NP ++ V L GKKL DY + + + E + FW++ Sbjct: 45 ATDRQSKKITDIENNP-NVHVLLGREGKKL----DEDYIEVEGLASIEEDSTLKNKFWNN 99 Query: 209 ILEYWYASRENPNKVLF 225 L+ W E+PN VL Sbjct: 100 SLKRWLLRPEDPNYVLI 116 >5INR-A nrPDB Length = 469 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 44/102 (43%), Gaps = 20/102 (19%) Query: 133 SPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAV 192 +P N ++ H+ S+K + VY NP+ W+ K +P++TAD P+E+ + Sbjct: 221 NPDFENYNLRHIFGSASIKDT----VY--NNPR-----TWYGQKFFSPDDTADDPMEQDL 269 Query: 193 EAFCEG---------KFIGGPFWDHILEYWYASRENPNKVLF 225 C KF+ +++ Y S +K LF Sbjct: 270 PFICHANRKISVEDVKFVLSSHFENTKYDVYGSGSQSDKTLF 311 >1Y0Y-A nrPDB Length = 353 Score = 29.3 bits (64), Expect = 2.4, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 15/87 (17%) Query: 225 FVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLP---- 280 V YE LKK E EFL + EE+++ V + L N+ +K+G+ P Sbjct: 6 MVDYELLKKVVEAPGVSGYEFLGIRDVVIEEIKDYVDEVKVDKLGNVIAHKKGEGPKVMI 65 Query: 281 -----------NGIETKTFFRKGEIGG 296 IE F R IGG Sbjct: 66 AAHMDQIGLMVTHIEKNGFLRVAPIGG 92 >5ZGM-A nrPDB Length = 110 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 24/34 (70%), Gaps = 3/34 (8%) Query: 231 LKKQTEVEMKRIAEFLE---CGFIEEEEVREIVK 261 LK ++E ++K + E L+ GFIEEEE++ ++K Sbjct: 36 LKGKSEAQVKEVFEILDKDQSGFIEEEELKSVLK 69 >1XMD-A nrPDB Length = 612 Score = 27.7 bits (60), Expect = 7.0, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 36/103 (34%), Gaps = 16/103 (15%) Query: 80 WLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNT 139 W + LL R K PV SGN PL + +L FS+ P + Sbjct: 130 WHNLNYWQLLRREKLPVHKSGNTPLDMNQFRML---------------FSTCKVPGITRD 174 Query: 140 HISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEE 182 I + ES I CR +F L H G + P E Sbjct: 175 SIMNYFKTESEGHCPTHIAVLCRGRAFVFDVL-HEGCLITPPE 216 >3TPL-A nrPDB Length = 433 Score = 27.3 bits (59), Expect = 9.4, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 19/38 (50%) Query: 200 FIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEV 237 FI G W+ IL YA P+ L ++ L KQT V Sbjct: 149 FINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV 186 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1Q44-A nrPDB 446 e-126 2GWH-A nrPDB 345 2e-95 1CJM-A nrPDB 342 1e-94 2REO-A nrPDB 341 2e-94 2Z5F-A nrPDB 340 4e-94 3U3O-A nrPDB 339 8e-94 5MEK-A nrPDB 339 2e-93 3BFX-A nrPDB 338 2e-93 2ZVQ-X nrPDB 328 2e-90 4JVN-A nrPDB 323 5e-89 1AQU-A nrPDB 318 3e-87 1Q22-A nrPDB 314 3e-86 1Q1Q-A nrPDB 310 5e-85 1ZD1-A nrPDB 297 3e-81 5X2B-D nrPDB 287 7e-78 1OV4-A nrPDB 276 1e-74 1X8L-A nrPDB 214 4e-56 3NIB-A nrPDB 204 5e-53 3MGC-A nrPDB 194 6e-50 4EEC-A nrPDB 179 1e-45 Sequences not found previously or not previously below threshold: 4GBM-A nrPDB 44 6e-05 4GOX-A nrPDB 41 6e-04 1T8T-A nrPDB 40 0.001 3RNL-A nrPDB 36 0.019 3AP1-A nrPDB 35 0.034 1NST-A nrPDB 35 0.039 3F5F-A nrPDB 32 0.32 4B2N-A nrPDB 32 0.44 5WRJ-A nrPDB 32 0.47 1WZ2-A nrPDB 30 1.0 4F5M-A nrPDB 30 1.4 4I6V-A nrPDB 30 2.0 2GLJ-A nrPDB 29 2.1 1X3Z-A nrPDB 29 2.3 2ZB3-A nrPDB 29 2.4 3ZXU-B nrPDB 29 2.5 2VNA-A nrPDB 29 3.2 5F13-A nrPDB 29 3.3 5GUP-L nrPDB 29 3.4 4FWE-A nrPDB 28 4.6 >1Q44-A nrPDB Length = 326 Score = 446 bits (1146), Expect = e-126, Method: Composition-based stats. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKR 60 MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKR Sbjct: 1 MSSSSSVPAYLGDEDLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKR 60 Query: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY 120 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY Sbjct: 61 FEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVY 120 Query: 121 YESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAP 180 YESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAP Sbjct: 121 YESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAP 180 Query: 181 EETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMK 240 EETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMK Sbjct: 181 EETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMK 240 Query: 241 RIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDT 300 RIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDT Sbjct: 241 RIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDT 300 Query: 301 LSESLAEEIDRTIEEKFKGSGLKFSS 326 LSESLAEEIDRTIEEKFKGSGLKFSS Sbjct: 301 LSESLAEEIDRTIEEKFKGSGLKFSS 326 >2GWH-A nrPDB Length = 298 Score = 345 bits (884), Expect = 2e-95, Method: Composition-based stats. Identities = 84/302 (27%), Positives = 147/302 (48%), Gaps = 22/302 (7%) Query: 36 SEIYEFQG-----LWHTQAILQGILICQK-----RFEAKDSDIILVTNPKSGTTWLKALV 85 SE + F G + + + ILQ C F+AK D+++ T PK+GTTW + +V Sbjct: 2 SEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIV 61 Query: 86 FALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHISHLS 145 + N S + +P L G E ++PSPR++ TH+ Sbjct: 62 ELIQNEGDVEKSKRAPTHQRFPFLEMKIPSL-GSGLEQ----AHAMPSPRILKTHLPFHL 116 Query: 146 LPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPF 205 LP S+ +CKI+Y RNPKD VS +HF + + A E+ E F GK G + Sbjct: 117 LPPSLLEKNCKIIYVARNPKDNMVSYYHFQR-MNKALPAPGTWEEYFETFLAGKVCWGSW 175 Query: 206 WDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSF 265 +H+ +W A ++ +++L++ YE++KK + E++++AEF+ ++++ + +IV SF Sbjct: 176 HEHVKGWWEA--KDKHRILYLFYEDMKKNPKHEIQKLAEFIGKK-LDDKVLDKIVHYTSF 232 Query: 266 ESLSNLEVNKEGKLPNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGL 322 + + + +P I + F RKG +G W+ + + E D ++K + L Sbjct: 233 DVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRL 292 Query: 323 KF 324 F Sbjct: 293 TF 294 >1CJM-A nrPDB Length = 295 Score = 342 bits (877), Expect = 1e-94, Method: Composition-based stats. Identities = 80/290 (27%), Positives = 136/290 (46%), Gaps = 17/290 (5%) Query: 42 QGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGN 101 +G+ + + L + F+A+ D+++ T PKSGTTW+ ++ + Sbjct: 16 KGVPLIKYFAEA-LGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLE--KCNR 72 Query: 102 HPLLVTNPHLLVPFLEGVYYESPDF--DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVY 159 P+ V VPFLE P P PRL+ +H+ LP+++ K+VY Sbjct: 73 APIYVR-----VPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVY 127 Query: 160 CCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASREN 219 RNPKD+ VS +HF + + +E F G+ G ++ H+ E+W SR + Sbjct: 128 VARNPKDVAVSYYHFHRMEKAHP-EPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTH 186 Query: 220 PNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKL 279 P VL++ YE++K+ + E+++I EF+ + EE + +V+ SF+ + + + Sbjct: 187 P--VLYLFYEDMKENPKREIQKILEFVGRS-LPEETMDFMVQHTSFKEMKKNPMTNYTTV 243 Query: 280 PNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 P + + F RKG G W+ T + + E D EK G L F S Sbjct: 244 PQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRS 293 >2REO-A nrPDB Length = 305 Score = 341 bits (875), Expect = 2e-94, Method: Composition-based stats. Identities = 92/293 (31%), Positives = 151/293 (51%), Gaps = 14/293 (4%) Query: 38 IYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVS 97 I E G+ + + F+AK D+IL T PKSGTTW+ ++ +LN Sbjct: 21 IMEVDGVPTLI-LSKEWWEKVANFQAKPDDLILATYPKSGTTWMHEILDMILNDGDVEKC 79 Query: 98 SSGNHPLLVTNPHLLVPFLEGVYYESPDFDF-SSLPSPRLMNTHISHLSLPESVKSSSCK 156 L + L + F + E PD +F + SP+L+ TH+ +P S+ +CK Sbjct: 80 KR--AQTLDRHAFLELKF---PHKEKPDLEFVLEMSSPQLIKTHLPSHLIPPSIWKENCK 134 Query: 157 IVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYAS 216 IVY RNPKD VS +HF + +A +E+ E F GK +GG ++DH+ +W A Sbjct: 135 IVYVARNPKDCLVSYYHFHR-MASFMPDPQNLEEFYEKFMSGKVVGGSWFDHVKGWWAA- 192 Query: 217 RENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKE 276 ++ +++L++ YE++KK + E+++I +FLE I EE + +I+ SF+ + + Sbjct: 193 -KDMHRILYLFYEDIKKDPKREIEKILKFLEKD-ISEEILNKIIYHTSFDVMKQNPMTNY 250 Query: 277 GKLPNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 LP I + F RKG G W++ + + EE D+ ++K GS L F + Sbjct: 251 TTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTFRT 303 >2Z5F-A nrPDB Length = 298 Score = 340 bits (873), Expect = 4e-94, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 143/304 (47%), Gaps = 12/304 (3%) Query: 26 SLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALV 85 S+ K L ++ G T A ++F ++ DI++ T PKSGTTW+ ++ Sbjct: 2 SMLSPKDILRKDLKLVHGYPMTCAFA-SNWEKIEQFHSRPDDIVIATYPKSGTTWVSEII 60 Query: 86 FALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHISHLS 145 +LN G V + +P L E PSPR++ TH+ Sbjct: 61 DMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQ----LEKNPSPRIVKTHLPTDL 116 Query: 146 LPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPF 205 LP+S ++CK++Y RN KD+ VS +HF + + E+ +E F GK G + Sbjct: 117 LPKSFWENNCKMIYLARNAKDVSVSYYHFD-LMNNLQPFPGTWEEYLEKFLTGKVAYGSW 175 Query: 206 WDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSF 265 + H+ +W E+P +LF+ YE++K+ + E+K+I FLE + +E + I+ SF Sbjct: 176 FTHVKNWWKRKEEHP--ILFLYYEDMKENPKEEIKKIIRFLEKN-LNDEILDRIIHHTSF 232 Query: 266 ESLSNLEVNKEGKLPNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGL 322 E + + + LP + + F RKG G W++ + + E+ D E + + L Sbjct: 233 EVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTAL 292 Query: 323 KFSS 326 +F + Sbjct: 293 QFRT 296 >3U3O-A nrPDB Length = 315 Score = 339 bits (870), Expect = 8e-94, Method: Composition-based stats. Identities = 79/290 (27%), Positives = 132/290 (45%), Gaps = 17/290 (5%) Query: 42 QGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGN 101 +G+ + + L + F+A+ D+++ T PKSGTTW+ ++ + Sbjct: 36 KGVPLIKYFAEA-LGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAP 94 Query: 102 HPLLVTNPHLLVPFLEGVYYESPDF--DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVY 159 + VPFLE P P+PRL+ TH+ LP+++ K+VY Sbjct: 95 -------IFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVY 147 Query: 160 CCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASREN 219 RN KD+ VS +HF + +E F G+ G ++ H+ E+W SR + Sbjct: 148 VARNAKDVAVSYYHFYHMAKVHP-EPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTH 206 Query: 220 PNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKL 279 P VL++ YE++K+ + E+++I EF+ + EE V +V+ SF+ + + + Sbjct: 207 P--VLYLFYEDMKENPKREIQKILEFVGHS-LPEETVDFMVQHTSFKEMKKNPMTNYTTV 263 Query: 280 PNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 P + F RKG G W+ T + + E D EK G L F S Sbjct: 264 PQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRS 313 >5MEK-A nrPDB Length = 322 Score = 339 bits (868), Expect = 2e-93, Method: Composition-based stats. Identities = 128/309 (41%), Positives = 183/309 (59%), Gaps = 12/309 (3%) Query: 23 LISSLPKEKGWLVSE-IYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWL 81 LIS+ P EKGW E + E+ G W ++L+G + Q+ F+A+ SD ++ + PK+GTTWL Sbjct: 15 LISTFPHEKGWRPKEPLIEYGGYWWLPSLLEGCIHAQEFFQARPSDFLVCSYPKTGTTWL 74 Query: 82 KALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHI 141 KAL FA+ NR +F SS+ PLL NPH VP++E + P+ D L +THI Sbjct: 75 KALTFAIANRSRFDDSSN---PLLKRNPHEFVPYIEIDFPFFPEVDVLKDKGNTLFSTHI 131 Query: 142 SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFI 201 + LP+SV S CK+VY R PKD F+S+W F K E +E++ + FC G Sbjct: 132 PYELLPDSVVKSGCKMVYIWREPKDTFISMWTFLHKERTELGPVSNLEESFDMFCRGLSG 191 Query: 202 GGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIE----EEEVR 257 GP+ +HIL YW A +ENP+++LF+ YE ++ +K +AEF+ GF + V Sbjct: 192 YGPYLNHILAYWKAYQENPDRILFLKYETMRADPLPYVKSLAEFMGHGFTAEEEEKGVVE 251 Query: 258 EIVKLCSFESLSNLEVNKEGK----LPNGIETKTFFRKGEIGGWRDTLSESLAEEIDRTI 313 ++V LCSFE+L NLE NK K P +FRKG++G W + L+ +A ID + Sbjct: 252 KVVNLCSFETLKNLEANKGEKDREDRPGVYANSAYFRKGKVGDWSNYLTPEMAARIDGLM 311 Query: 314 EEKFKGSGL 322 EEKFKG+GL Sbjct: 312 EEKFKGTGL 320 >3BFX-A nrPDB Length = 296 Score = 338 bits (866), Expect = 2e-93, Method: Composition-based stats. Identities = 74/273 (27%), Positives = 137/273 (50%), Gaps = 16/273 (5%) Query: 58 QKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLE 117 + FEAK D+++ T PK+GTTW++ +V + ++ + H PF+E Sbjct: 32 IQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRA----IIQHRH---PFIE 84 Query: 118 GVYYESPDF--DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFG 175 P ++PSPR++ TH+S LP S ++CK +Y RN KD VS +HF Sbjct: 85 WARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQ 144 Query: 176 KKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQT 235 + + E+ E F GK + G ++DH+ +W ++ +++LF+ YE++K+ Sbjct: 145 R-MNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MKDRHQILFLFYEDIKRDP 201 Query: 236 EVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIET---KTFFRKG 292 + E++++ +F+ ++E + +IV+ SFE + + + I +F RKG Sbjct: 202 KHEIRKVMQFMGKK-VDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKG 260 Query: 293 EIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFS 325 +G W++ + + E D K +G+ + FS Sbjct: 261 TVGDWKNHFTVAQNERFDEIYRRKMEGTSINFS 293 >2ZVQ-X nrPDB Length = 295 Score = 328 bits (841), Expect = 2e-90, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 142/297 (47%), Gaps = 15/297 (5%) Query: 34 LVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHK 93 E+ + +G+ +I + + FEA+ DI++ T PKSGTTW+ ++ + N Sbjct: 8 FRRELVDVEGIPLFWSIAEHWSQV-ESFEARPDDILISTYPKSGTTWVSEILDLIYNNGD 66 Query: 94 FPVSSSGNHPLLVTNPHLLVP-FLEGVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKS 152 V L++P GV +++PSPR++ TH+ LP S Sbjct: 67 AEKCKRDAIYKRVPFMELIIPGITNGVEM------LNNMPSPRIVKTHLPVQLLPSSFWK 120 Query: 153 SSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEY 212 + CKI+Y RN KD+ VS ++F + E+ +E F G+ GP++DH+ + Sbjct: 121 NDCKIIYVARNAKDVVVSYYYFYQMAKIHP-EPGTWEEFLEKFMAGQVSFGPWYDHVKSW 179 Query: 213 WYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLE 272 W +E ++L++ YE++K+ + E+++I +FLE I EE + +I+ SF + Sbjct: 180 WEKRKE--YRILYLFYEDMKENPKCEIQKILKFLEKD-IPEEILNKILYHSSFSVMKENP 236 Query: 273 VNKEGKLPNGIETKT---FFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 + + F RKG G W++ + + E+ + +K + S LKF S Sbjct: 237 SANYTTMMKEEMDHSVSPFMRKGISGDWKNQFTVAQYEKFEEDYVKKMEDSTLKFRS 293 >4JVN-A nrPDB Length = 294 Score = 323 bits (829), Expect = 5e-89, Method: Composition-based stats. Identities = 81/273 (29%), Positives = 130/273 (47%), Gaps = 16/273 (5%) Query: 59 KRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEG 118 + F+A+ D+++ T PKSGTTW+ +V+ + +PFLE Sbjct: 31 EAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDV-------IFNRIPFLEC 83 Query: 119 VYYESPDF--DFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGK 176 + + SPR++ TH+ LP S CKI+Y CRN KD+ VS ++F Sbjct: 84 RKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFL 143 Query: 177 KLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTE 236 +A + VE F +G+ G ++ H+ +W + +VLF+ YE+LK+ Sbjct: 144 MVAGHPNPGS-FPEFVEKFMQGQVPYGSWYKHVKSWWEKGKS--PRVLFLFYEDLKEDIR 200 Query: 237 VEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIET---KTFFRKGE 293 E+ ++ FLE EE V I+ SF+ + N LP+ I F RKG Sbjct: 201 KEVIKLIHFLERK-PSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGI 259 Query: 294 IGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 G W++ +E+L E+ D+ E++ K S LKF + Sbjct: 260 TGDWKNHFTEALNEKFDKHYEQQMKESTLKFRT 292 >1AQU-A nrPDB Length = 297 Score = 318 bits (814), Expect = 3e-87, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 127/272 (46%), Gaps = 16/272 (5%) Query: 59 KRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLE- 117 + F A+ D+++ T PKSGTTW+ +V+ + +P+LE Sbjct: 34 EMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDVEKCKEDA-------IFNRIPYLEC 86 Query: 118 -GVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGK 176 + SPR++ TH+ LP S +CK++Y CRN KD+ VS ++F Sbjct: 87 RNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLL 146 Query: 177 KLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTE 236 + + VE F +G+ G ++DH+ +W S+ ++VLF+ YE++K+ Sbjct: 147 MITSYPNPKS-FSEFVEKFMQGQVPYGSWYDHVKAWWEKSKN--SRVLFMFYEDMKEDIR 203 Query: 237 VEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIET---KTFFRKGE 293 E+ ++ EFLE E V I++ SF+ + N +P + F RKG Sbjct: 204 REVVKLIEFLERK-PSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGI 262 Query: 294 IGGWRDTLSESLAEEIDRTIEEKFKGSGLKFS 325 IG W++ E+L E D +++ K +KF Sbjct: 263 IGDWKNHFPEALRERFDEHYKQQMKDCTVKFR 294 >1Q22-A nrPDB Length = 299 Score = 314 bits (804), Expect = 3e-86, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 141/294 (47%), Gaps = 25/294 (8%) Query: 34 LVSEIYEFQGLWHTQAI--LQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNR 91 L E + ++G+ + L+ I + + + +D DI ++T PKSGTTW+ ++ +L Sbjct: 14 LPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKE 73 Query: 92 HKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLP---SPRLMNTHISHLSLPE 148 P + + VP E + SLP SPRLM++H+ + Sbjct: 74 GD---------PSWIRS----VPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTK 120 Query: 149 SVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDH 208 + SS K++Y RNP+D+ VSL+H+ K + P ++ + F +G+ G ++DH Sbjct: 121 AFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTP-DQFLRDFLKGEVQFGSWFDH 179 Query: 209 ILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESL 268 I W + N LF+TYEEL++ + ++RI FL + +E + +V +F ++ Sbjct: 180 IK-GWLRMKGKDN-FLFITYEELQQDLQGSVERICGFLGR-PLGKEALGSVVAHSTFSAM 236 Query: 269 SNLEVNKEGKLPNGIETK---TFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKG 319 ++ LP + F RKG G W++ + + +E DR ++ +G Sbjct: 237 KANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRG 290 >1Q1Q-A nrPDB Length = 350 Score = 310 bits (794), Expect = 5e-85, Method: Composition-based stats. Identities = 80/305 (26%), Positives = 144/305 (47%), Gaps = 25/305 (8%) Query: 23 LISSLPKEKGWLVSEIYEFQGLWHTQAI--LQGILICQKRFEAKDSDIILVTNPKSGTTW 80 + S P L E + ++G+ + L+ I + + + +D DI ++T PKSGTTW Sbjct: 1 MASPPPFHSQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTW 60 Query: 81 LKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLP---SPRLM 137 + ++ +L P + + VP E + SLP SPRLM Sbjct: 61 MIEIICLILKEGD---------PSWIRS----VPIWERAPWCETIVGAFSLPDQYSPRLM 107 Query: 138 NTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCE 197 ++H+ ++ SS K++Y RNP+D+ VSL+H+ K + P ++ + F + Sbjct: 108 SSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTP-DQFLRDFLK 166 Query: 198 GKFIGGPFWDHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVR 257 G+ G ++DHI W + N LF+TYEEL++ + ++RI FL + +E + Sbjct: 167 GEVQFGSWFDHIK-GWLRMKGKDN-FLFITYEELQQDLQGSVERICGFLGR-PLGKEALG 223 Query: 258 EIVKLCSFESLSNLEVNKEGKLPNGIETK---TFFRKGEIGGWRDTLSESLAEEIDRTIE 314 +V +F ++ ++ LP + F RKG G W++ + + +E DR Sbjct: 224 SVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYR 283 Query: 315 EKFKG 319 ++ +G Sbjct: 284 KQMRG 288 >1ZD1-A nrPDB Length = 284 Score = 297 bits (761), Expect = 3e-81, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 136/299 (45%), Gaps = 27/299 (9%) Query: 28 PKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFA 87 P G S+ +EF G+ +G + F + SD+ +VT PKSGT+ L+ +V+ Sbjct: 9 PSTPGEFESKYFEFHGV-RLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSLLQEVVYL 67 Query: 88 LLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDF-SSLPSPRLMNTHISHLSL 146 + + + N +P LE Y P D L SPRL+ +H+ + L Sbjct: 68 VSQGADP-------DEIGLMNIDEQLPVLE---YPQPGLDIIKELTSPRLIKSHLPYRFL 117 Query: 147 PESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFW 206 P + + K++Y RNPKD+ VS + F + L ++ F K G ++ Sbjct: 118 PSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRG-TFQEFCRRFMNDKLGYGSWF 176 Query: 207 DHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFE 266 +H+ E+W R + N VLF+ YE++ + ++++A FL ++ ++ + + C Sbjct: 177 EHVQEFW-EHRMDSN-VLFLKYEDMHRDLVTMVEQLARFLGVS-CDKAQLEALTEHC--H 231 Query: 267 SLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFS 325 L + N E LP G +G +G W+D + S+ E+ D ++K L F Sbjct: 232 QLVDQCCNAEA-LPVG--------RGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFD 281 >5X2B-D nrPDB Length = 281 Score = 287 bits (733), Expect = 7e-78, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 138/291 (47%), Gaps = 29/291 (9%) Query: 38 IYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVS 97 ++++ G++ + + +L F+A++ DI LV+ PKSGT WL ++ + + Sbjct: 3 LHKYMGIFFSTMSSEELLGSLDSFDAREDDIFLVSYPKSGTHWLAEVIERIPDAG----- 57 Query: 98 SSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKI 157 + +T+P + + +E +P R + TH+++ LP +VK CKI Sbjct: 58 ------ITLTSP---IELGDISKFEE----LKRIPKRRAIPTHLNYEMLPVTVKQKQCKI 104 Query: 158 VYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASR 217 +Y RNPKD VS++H+ + P + +E F +G + G ++DH+L + Sbjct: 105 IYIVRNPKDTAVSMFHYYRD-NPNLPSTETWAAFLELFLKGDVVYGSWFDHVLSW--EEH 161 Query: 218 ENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEG 277 +N VLF+ YEE+KK +K+I FL + + E+ +I + SF + + KE Sbjct: 162 KNDKNVLFIFYEEMKKDFVKSLKKITAFLGID-VNDSEMAKIARSTSFSEMKSN-AAKEN 219 Query: 278 KLPNGI------ETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGL 322 PN + + FRKG +G W + + D EK + S + Sbjct: 220 CDPNHVICALTSDRNLVFRKGVVGDWINYFTPKQNRGFDELFTEKMRNSDV 270 >1OV4-A nrPDB Length = 293 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 80/286 (27%), Positives = 139/286 (48%), Gaps = 24/286 (8%) Query: 41 FQGLWHTQA--ILQGILICQKRFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSS 98 F+G+ + + + F +D D+I++T PKSGT WL ++ + ++ Sbjct: 16 FEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQ 75 Query: 99 SGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLP---SPRLMNTHISHLSLPESVKSSSC 155 S VP E + + +++L SPRL ++H+ P+S SS Sbjct: 76 S-------------VPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKA 122 Query: 156 KIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYA 215 K++Y RNP+D+ VS + F K + + E+ E FC+G + G ++DHI W Sbjct: 123 KVIYLMRNPRDVLVSGYFFWKNMKFIKKPKS-WEEYFEWFCQGTVLYGSWFDHI-HGWMP 180 Query: 216 SRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNK 275 RE N L ++YEELK+ T +++I +FL +E EE+ I+K SF+S+ +++ Sbjct: 181 MREEKN-FLLLSYEELKQDTGRTIEKICQFLG-KTLEPEELNLILKNSSFQSMKENKMSN 238 Query: 276 EGKLPNG--IETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKG 319 L ++ RKG G W++ + + AE+ D+ +EK Sbjct: 239 YSLLSVDYVVDKTQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMAD 284 >1X8L-A nrPDB Length = 351 Score = 214 bits (544), Expect = 4e-56, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 34/296 (11%) Query: 60 RFEAKDSDIILVTNPKSGTTWLKALVFALLNRHKFPVSSSG-------------NHPLLV 106 + +D+ + + +SGTT + LV+ + N F + + P Sbjct: 58 NMPLRPTDVFVASYQRSGTTMTQELVWLIENDLNFEAAKTYMSLRYIYLDGFMIYDPEKQ 117 Query: 107 TNPHLLVP------------FLEGVYYESPDFDFSSLPSP-RLMNTHISHLSLPESVKSS 153 + ++P LE + P+ R + TH+ +P Sbjct: 118 EEYNDILPNPENLDMERYLGLLEYSSRPGSSLLAAVPPTEKRFVKTHLPLSLMPP-NMLD 176 Query: 154 SCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHILEYW 213 + K+VY R+P+D+ VS +H + L + E F G + P+++H+ E W Sbjct: 177 TVKMVYLARDPRDVAVSSFHHARLLY-LLNKQSNFKDFWEMFHRGLYTLTPYFEHVKEAW 235 Query: 214 YASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNL-E 272 A R +PN +LF+ YE+ K + RIA+FL + EE+++ + + +FE N Sbjct: 236 -AKRHDPN-MLFLFYEDYLKDLPGSIARIADFLGKK-LSEEQIQRLSEHLNFEKFKNNGA 292 Query: 273 VNKEGKLPNGI--ETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEKFKGSGLKFSS 326 VN E GI + + F RKG+ G WRD E + ++ ++ I++ K + L++ + Sbjct: 293 VNMEDYREIGILADGEHFIRKGKAGCWRDYFDEEMTKQAEKWIKDNLKDTDLRYPN 348 >3NIB-A nrPDB Length = 309 Score = 204 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 108/270 (40%), Gaps = 34/270 (12%) Query: 69 ILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDF 128 + + PK+G TWL+ ++ A + +G P + + LEG+ + D Sbjct: 40 WIASYPKAGNTWLRCMLAAYI---------TGKAPQTWKDMETVSLELEGMLHLG-DMPP 89 Query: 129 SSLPSPRLMNTHI-SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYP 187 + P L+ TH+ + + + ++ K++Y RNP+D+ +S + + Sbjct: 90 TEPTKPVLVKTHLKADVPVLGLYSEATAKVLYLVRNPRDILLSAMRMTAISRDDMESSRT 149 Query: 188 IEKAVEAFCEGK---------FIGGPFWDHILEYWYASREN--PN-KVLFVTYEELKKQT 235 F + G W + W S + PN VL + YE+LK Sbjct: 150 ---FARDFIANEGLRMRGRGGGAGLGSWPENVRIWTESSRDRFPNADVLTMRYEDLKGDP 206 Query: 236 EVEMKRIAEFLECGF-IEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGE- 293 I EFL+ G ++ E++R V C+ E + LE K + + T R GE Sbjct: 207 VARFSEIVEFLDLGDPVDIEDIRRAVAACTLERMRELE--KRSQQQGQWASMTGGRGGEK 264 Query: 294 ---IGGWRDTLSES-LAEEIDRTIEEKFKG 319 +G R S S L E+I+ +E G Sbjct: 265 HPFVGEGRYDQSLSFLGEDIESAYQELLHG 294 >3MGC-A nrPDB Length = 319 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 102/278 (36%), Gaps = 40/278 (14%) Query: 69 ILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDF 128 + + PK+G TW++ ++ A + +G P + + LE + D Sbjct: 40 WIASYPKAGNTWVRCMLAAYI---------TGKAPQVWNDIDAESLTLEAMLRFG-DLPP 89 Query: 129 SSLPSPRLMNTHI-SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYP 187 + P L+ TH+ + + + ++ K++Y RNP+DM +S Sbjct: 90 AEPMEPVLVKTHLKADVPVLGLYGEATAKVLYLVRNPRDMLLSSMRMASI---SRDDVEK 146 Query: 188 IEKAVEAFCEGKFIG-----------GPFWDHILEYWYASREN--PN-KVLFVTYEELKK 233 F + +G W + W S + PN VL + YE+LK Sbjct: 147 SRDFARKFIANEGLGWNALGAGGGVGLGSWPENVRSWTESSSDRFPNADVLTMRYEDLKG 206 Query: 234 QTEVEMKRIAEFLECGF-IEEEEVREIVKLCSFESLSNLEVNKEGK---LPNGIETKTFF 289 I EFL+ G ++ E++R V + E + LE E + P Sbjct: 207 DPVARFSEIVEFLDLGGPVDIEDIRRAVAASTLERMRELEKRSEQQGGGSPIRHGDARMM 266 Query: 290 RKG-------EIGGWRDTLSES-LAEEIDRTIEEKFKG 319 + G +G R S S L E+I+ +E G Sbjct: 267 KGGPGGARPQFVGEGRYDQSLSFLGEDIESDYQELLHG 304 >4EEC-A nrPDB Length = 286 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 109/272 (40%), Gaps = 39/272 (14%) Query: 69 ILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYY--ESPDF 126 + + PK+G WL+ ++ + + VP LEG+ E+P Sbjct: 22 WIASYPKAGGHWLRCMLTSYVTGEPVE---------TWPGIQAGVPHLEGLLRDGEAPSA 72 Query: 127 DFSSLPSPRLMNTHI-SHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETAD 185 D L+ TH + + + S+ K+V RNP+D +SL K + PE+ Sbjct: 73 DPDEQ---VLLATHFTADRPVLRFYRESTAKVVCLIRNPRDAMLSLMRM-KGIPPEDVE- 127 Query: 186 YPIEKAVEAFCEGK-------FIGGPFWDHILEYWYASREN--PN-KVLFVTYEELKKQT 235 K E F + + G W + W S PN VL V YE+L+K Sbjct: 128 -ACRKIAETFIADEGFSSVRIWAGEGSWPENIRSWTDSVHESFPNAAVLAVRYEDLRKDP 186 Query: 236 EVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKG--- 292 E E+ ++ +FLE G + V + V C+ E + +E + KL G+ET +G Sbjct: 187 EGELWKVVDFLELG--GRDGVADAVANCTLERMREME--ERSKL-LGLETTGLMTRGGKQ 241 Query: 293 --EIGGWRDTLSES-LAEEIDRTIEEKFKGSG 321 +G S + ++I++ + G Sbjct: 242 LPFVGKGGQRKSLKFMGDDIEKAYADLLHGET 273 >4GBM-A nrPDB Length = 323 Score = 44.3 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 34/226 (15%), Positives = 78/226 (34%), Gaps = 48/226 (21%) Query: 65 DSDIILVTNPKSGTTWLKALVFALLN---------------RHKFPVSSSGNHPLLVTNP 109 I ++++P+SG+T L+ ++ + + + + + Sbjct: 32 PGIIFILSSPRSGSTLLRVMLAGHSSLFSPPELHLLPFNTMKERQEQLNLSYLGEGLQKT 91 Query: 110 HLLVPFLEGVYYESPDFDFSSLP--------------SPRLMNTHISHLSLPESVKS--- 152 + V L+ ++ D S +PRL+ ++ ++ Sbjct: 92 FMEVKNLDATASQALIKDLESQNLSIQQVYGMLQENIAPRLLVDKSPTYAMEPTILERGE 151 Query: 153 ---SSCKIVYCCRNPKDMFVSL--WHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWD 207 ++ K +Y R+P + S K + E Y + + V Sbjct: 152 ALFANSKYIYLVRHPYSVIESFVRMRMQKLVGLGEENPYRVAEQV---------WAKSNQ 202 Query: 208 HILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEE 253 +IL + S+ P + + YE+L K+ + + ++ +FL F E Sbjct: 203 NILNF--LSQLEPERQHQIRYEDLVKKPQQVLSQLCDFLNVPFEPE 246 >4GOX-A nrPDB Length = 313 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 37/108 (34%), Gaps = 16/108 (14%) Query: 153 SSCKIVYCCRNPKDMFVSL--WHFGKKLAPEETADYPIEKAVEAFCEGKFIGGPFWDHIL 210 K ++ R+P + S K L E+ Y + +++ + Sbjct: 147 DQAKYIHLVRHPYAVIESFTRLRMDKLLGAEQQNPYALAESI------------WRTSNR 194 Query: 211 EYWYASRE-NPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIEEEEVR 257 R ++ L V YE+L + + I +FL F +E + Sbjct: 195 NILDLGRTVGADRYLQVIYEDLVRDPRKVLTNICDFLGVDF-DEALLN 241 >1T8T-A nrPDB Length = 271 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 34/192 (17%), Positives = 60/192 (31%), Gaps = 21/192 (10%) Query: 69 ILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESP-DFD 127 I++ K GT L + R V + G P + D Sbjct: 21 IIIGVKKGGTRALLEFL-----RVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQ 75 Query: 128 FSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYP 187 + +P T + + S S K++ R+P +S + P+ Sbjct: 76 ITMEKTPSYFVTREAPARI--SAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFES 133 Query: 188 IEKAVEAFCEGKF-------IGGPFWDHILEYWYASRENP-NKVLFVTYEELKKQTEVEM 239 + + G G + H+ + R P ++LFV+ E L E+ Sbjct: 134 LT--FKNRTAGLIDTSWSAIQIGIYAKHLEHW---LRHFPIRQMLFVSGERLISDPAGEL 188 Query: 240 KRIAEFLECGFI 251 R+ +FL I Sbjct: 189 GRVQDFLGLKRI 200 >3RNL-A nrPDB Length = 311 Score = 36.3 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 38/114 (33%), Gaps = 13/114 (11%) Query: 154 SCKIVYCCRNPKDMFVS-LWHFGKKLAPEETADYPI---EKAVEAFCEGKFIG---GPFW 206 KI+ RNP D S H + + + E+ + E + G + Sbjct: 109 DAKILIMLRNPVDRAFSAYMHLVRDERETLSFRESLAKEEERIRQHYEPLWYYRAVGLYA 168 Query: 207 DHILEYWYA-SRENPNKVLFVTYEELKKQTEVEMKRIAEFLEC--GFIEEEEVR 257 + Y RE +LF EE + ++ FL F+ + +R Sbjct: 169 AQVKRYLDVFGREQVKVILF---EEFARDPVQVVRDCCAFLGVSTDFVPDTSIR 219 >3AP1-A nrPDB Length = 337 Score = 35.5 bits (80), Expect = 0.034, Method: Composition-based stats. Identities = 38/214 (17%), Positives = 67/214 (31%), Gaps = 51/214 (23%) Query: 68 IILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFD 127 I + P+SGTT ++A++ A P G ++ + E D Sbjct: 49 IFVGGVPRSGTTLMRAMLDA------HPEVRCGEETRIIPRVLAMRQAWSKSGREKLRLD 102 Query: 128 FSSLPSPRL-----------MNTH-ISHLSL----PESVKSS--------SCKIVYCCRN 163 + + L + H L P ++KSS + K + R+ Sbjct: 103 EAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLLMVRD 162 Query: 164 PKDMFVSLWHFGKKLAPEETADY-----PIEKAVEAFCEGKFIGGPFWDHILEYWYASRE 218 + S+ +A + + Y KA+E + Y Sbjct: 163 GRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIE----------------VMYAQCMEV 206 Query: 219 NPNKVLFVTYEELKKQTEVEMKRIAEFLECGFIE 252 K L V YE+L +K I +FL + + Sbjct: 207 GKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSD 240 >1NST-A nrPDB Length = 325 Score = 35.1 bits (79), Expect = 0.039, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 77/244 (31%), Gaps = 39/244 (15%) Query: 24 ISSLPKEKGWL-VSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTWLK 82 I S K+ W E + +W + RF ++++ K+GTT L Sbjct: 16 IFSEEKDPLWQDPCEDKRHKDIWSKEKTC-------DRFP----KLLIIGPQKTGTTALY 64 Query: 83 ALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESP-----DFDFSSLPSPRLM 137 + + SS + N H ++ P DF S Sbjct: 65 LFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYF 124 Query: 138 NTHISHL----SLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVE 193 ++ ++ LP K++ NP D S + + Y + + Sbjct: 125 DSEVAPRRAAALLP------KAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVIT 178 Query: 194 ---------AFCEGKFIGGPFW-DHILEYWYASRENPNKVLFVTYEELKKQTEVEMKRIA 243 + + + ++ HI + A + N++L + + L+ + M + Sbjct: 179 AGSDASSKLRALQNRCLVPGWYATHIERWLSAY--HANQILVLDGKLLRTEPAKVMDMVQ 236 Query: 244 EFLE 247 +FL Sbjct: 237 KFLG 240 >3F5F-A nrPDB Length = 658 Score = 32.0 bits (71), Expect = 0.32, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 49/114 (42%), Gaps = 8/114 (7%) Query: 65 DSDIILVTN--PKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYE 122 + D++++ N PK+ +T + + L ++++ V + NP + + + V + Sbjct: 373 EDDVVIIYNRVPKTASTSFTNIAYDLCAKNRYHVL---HINTTKNNPVMSLQ--DQVRFV 427 Query: 123 SPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGK 176 + + P + H+S+L + + R+P + VS ++F + Sbjct: 428 KNVTSWKEM-KPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLR 480 >4B2N-A nrPDB Length = 662 Score = 31.6 bits (70), Expect = 0.44, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 22/66 (33%), Gaps = 1/66 (1%) Query: 71 VTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSS 130 T PK+ T L + + S + + + GVY D + Sbjct: 349 ATYPKTINTALAEQGAVIYHERDLWASGANGA-IPKPAGNGSCASCHGVYSPRHAADPNY 407 Query: 131 LPSPRL 136 LP PRL Sbjct: 408 LPDPRL 413 >5WRJ-A nrPDB Length = 303 Score = 31.6 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 34/195 (17%), Positives = 60/195 (30%), Gaps = 25/195 (12%) Query: 68 IILVTNPKSGTTWLKALVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFD 127 I + P+SGTT ++A++ A P G ++ L E D Sbjct: 34 IFIGGVPRSGTTLMRAMLDA------HPDIRCGEETRVIPRILALKQMWSRSSKEKIRLD 87 Query: 128 FSSLPSPRLMNTHISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPE------ 181 + + L + + L E + Y C N + + +L P Sbjct: 88 EAGVTDEVLDSAMQA--FLLEIIVKHGEPAPYLC-NKDPFALKSLTYLSRLFPNAKFLLM 144 Query: 182 --ETADYPIEKAVEAFCEGKFIGGPFWDHILEYWYASRENPN--------KVLFVTYEEL 231 + F + D + ++ A N K + V YE+L Sbjct: 145 VRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQL 204 Query: 232 KKQTEVEMKRIAEFL 246 E M+ + +FL Sbjct: 205 VLHPERWMRTLLKFL 219 >1WZ2-A nrPDB Length = 967 Score = 30.5 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 33/85 (38%), Gaps = 11/85 (12%) Query: 159 YCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFC-EGKFIGGPFWDHILEYWYASR 217 Y R D++V L + E+ E EG + + + E+W + Sbjct: 781 YVLRTLADVWVRLM--------APFTPHICEELWEKLGGEGFVSLAKWPEPVEEWWNETI 832 Query: 218 ENPNKVLFVTYEELKKQTEVEMKRI 242 E + + E++K+ +E+ +I Sbjct: 833 EAEEEFIRSVMEDIKE--IIEVAKI 855 >4F5M-A nrPDB Length = 406 Score = 30.1 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 26/62 (41%), Gaps = 4/62 (6%) Query: 15 DLTQETRALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILV-TN 73 D T E ++ L EKGWL + +QG L+ + F A ++I+ + Sbjct: 198 DPTLEQWQTLAQLSVEKGWLPLFDFAYQGFARG---LEEDAEGLRAFAAMHKELIVASSY 254 Query: 74 PK 75 K Sbjct: 255 SK 256 >4I6V-A nrPDB Length = 434 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 26/78 (33%), Gaps = 3/78 (3%) Query: 140 HISHLSLPESVKSSSCKIVYCCRNPKDMFVSLWHFGKKLAPEETADYPIEKAVEAFCEGK 199 H+ + + VY ++ D VSL+ + + +PI A Sbjct: 271 HLPFDLMIGVNRRVYESGVYQGQDLFDQRVSLYQYRRLFNAFPRVKFPISVLAHASNMEL 330 Query: 200 FIGGPFWDHIL---EYWY 214 + +++ +WY Sbjct: 331 VSYAWIFPNVIANGHWWY 348 >2GLJ-A nrPDB Length = 461 Score = 29.3 bits (64), Expect = 2.1, Method: Composition-based stats. Identities = 9/65 (13%), Positives = 23/65 (35%), Gaps = 8/65 (12%) Query: 257 REIVKLCSFESLSNLEVNKEGKLPNGIETKTFFRKGEIGGWRDTLSESLAEEIDRTIEEK 316 I SFE++ ++ K+ + ++ + G G ++ + T+ + Sbjct: 262 DRICAYTSFEAMLEMKNAKKTCITILVDKEEVGSIGATG--------MQSKFFENTVADI 313 Query: 317 FKGSG 321 G Sbjct: 314 MSLCG 318 >1X3Z-A nrPDB Length = 335 Score = 29.3 bits (64), Expect = 2.3, Method: Composition-based stats. Identities = 7/42 (16%), Positives = 12/42 (28%), Gaps = 2/42 (4%) Query: 264 SFESLSNLEVNKEGKLPNGIETKTFF--RKGEIGGWRDTLSE 303 + E + P + RKG G W + + Sbjct: 152 TVEIYKCNRCGNITRFPRYNDPIKLLETRKGRCGEWCNLFTL 193 >2ZB3-A nrPDB Length = 353 Score = 29.3 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 21/126 (16%), Positives = 48/126 (38%), Gaps = 1/126 (0%) Query: 21 RALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTW 80 R +++S P + G V+E + + A+ +G + + + + D + N +GT + Sbjct: 7 RVVLNSRPGKNGNTVAENFRVEEFSLPDALNEGQVQVRTLYLSVDPYMRCKMNEDTGTDY 66 Query: 81 LKA-LVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNT 139 L + + + V H L + + D + P+L++ Sbjct: 67 LAPWQLAQVADGGGIGVVEESKHQKLTKGDFVTSFYWPWQTKAILDGNGLEKVDPQLVDG 126 Query: 140 HISHLS 145 H+S+ Sbjct: 127 HLSYFL 132 >3ZXU-B nrPDB Length = 270 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 22/49 (44%) Query: 226 VTYEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCSFESLSNLEVN 274 + Y E + V M + +FL + E+ + +IV+ F SN + Sbjct: 169 IQYAEDTQNVNVAMMAVVQFLRIKELHEQMISKIVEASKFIRASNNTIT 217 >2VNA-A nrPDB Length = 357 Score = 28.9 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 50/126 (39%), Gaps = 1/126 (0%) Query: 21 RALISSLPKEKGWLVSEIYEFQGLWHTQAILQGILICQKRFEAKDSDIILVTNPKSGTTW 80 R +++S P + G V+E + + ++ I +G + + + + D + N +GT + Sbjct: 6 RVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDY 65 Query: 81 LKA-LVFALLNRHKFPVSSSGNHPLLVTNPHLLVPFLEGVYYESPDFDFSSLPSPRLMNT 139 + + +++ + H L + + D + P+L++ Sbjct: 66 ITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDG 125 Query: 140 HISHLS 145 H+S+ Sbjct: 126 HLSYFL 131 >5F13-A nrPDB Length = 471 Score = 28.9 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 25/195 (12%), Positives = 53/195 (27%), Gaps = 43/195 (22%) Query: 108 NPHLLVPFLEGVYYESPDFDFSSLPSPRLMNTHISHLSLPESVKSSSCKIV--------Y 159 + H G +E + L I KI Y Sbjct: 37 SKHQETEKSNGTKFEQGEVIKKELKE---FRQEIIDRVPLRPFTEEEIKIANVPLSFNEY 93 Query: 160 CCRNPK------DMFVSLWHFGKKLAPEETADYPIEKAVEAFCE-GKFIGGPFWDHILEY 212 ++P+ + S + +++ K + F + + ++E Sbjct: 94 LKKHPEVNWGAVEWLFSEVYLYRRVNVLFQRQCEWAKF-DIFNRLKQSTFESSFYGVVE- 151 Query: 213 WYASRENPNKVLFVTYE-------ELKKQTEVEMKRIA-----EFLECGFIEEEEVREIV 260 L + YE E+K+ E+ I EF+E ++ Sbjct: 152 -----------LALRYENLLPQLREMKQNPGNEIDDILKVLFKEFIEISLWGNATDLSLL 200 Query: 261 KLCSFESLSNLEVNK 275 + E + +++ K Sbjct: 201 TNATLEDIKSIQGAK 215 >5GUP-L nrPDB Length = 377 Score = 28.9 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 228 YEELKKQTEVEMKRIAEFLECGFIEEEEVREIVKLCS 264 Y+ + + ++ +I F+E +++ +R++V+ + Sbjct: 89 YDTMHLRPMGDLGQII-FMEWNGKDKDSIRKVVEHSN 124 >4FWE-A nrPDB Length = 796 Score = 28.2 bits (61), Expect = 4.6, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 17/37 (45%), Gaps = 4/37 (10%) Query: 293 EIGGWRDTLS----ESLAEEIDRTIEEKFKGSGLKFS 325 + WR + L E+I+ + K SG++FS Sbjct: 467 VVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFS 503 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.129 0.363 Lambda K H 0.267 0.0397 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,612,918 Number of Sequences: 36641 Number of extensions: 484631 Number of successful extensions: 1664 Number of sequences better than 10.0: 42 Number of HSP's better than 10.0 without gapping: 50 Number of HSP's successfully gapped in prelim test: 29 Number of HSP's that attempted gapping in prelim test: 1439 Number of HSP's gapped (non-prelim): 84 length of query: 326 length of database: 10,336,785 effective HSP length: 97 effective length of query: 229 effective length of database: 6,782,608 effective search space: 1553217232 effective search space used: 1553217232 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.4 bits)