BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P52789 (917 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5HFU-A nrPDB 1856 0.0 4FOI-A nrPDB 1437 0.0 1BG3-A nrPDB 1410 0.0 3HM8-A nrPDB 611 e-175 3W0L-A nrPDB 529 e-150 4DCH-A nrPDB 518 e-147 1BDG-A nrPDB 386 e-107 5ZQT-A nrPDB 272 4e-73 3O1W-A nrPDB 272 4e-73 3B8A-X nrPDB 249 4e-66 1IG8-A nrPDB 244 1e-64 4QS9-A nrPDB 244 1e-64 2YHX-A nrPDB 42 0.002 1HKG-A nrPDB 40 0.003 4LS7-A nrPDB 30 5.3 4N2M-A nrPDB 30 5.7 1WDI-A nrPDB 30 6.5 5CY4-A nrPDB 29 8.2 >5HFU-A nrPDB Length = 923 Score = 1856 bits (4807), Expect = 0.0, Method: Compositional matrix adjust. Identities = 901/901 (100%), Positives = 901/901 (100%) Query: 17 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE Sbjct: 23 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 77 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR Sbjct: 143 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 202 Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC Sbjct: 203 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 262 Query: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE Sbjct: 263 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 322 Query: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ Sbjct: 323 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 382 Query: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP Sbjct: 383 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 442 Query: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 496 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 502 Query: 497 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 556 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH Sbjct: 503 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 562 Query: 557 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 616 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL Sbjct: 563 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 622 Query: 617 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 676 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL Sbjct: 623 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 682 Query: 677 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 736 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP Sbjct: 683 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 737 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 796 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 797 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 856 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV Sbjct: 803 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 862 Query: 857 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ 916 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ Sbjct: 863 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ 922 Query: 917 R 917 R Sbjct: 923 R 923 Score = 569 bits (1466), Expect = e-162, Method: Compositional matrix adjust. Identities = 266/451 (58%), Positives = 351/451 (77%) Query: 461 YRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATP 520 ++ +DQ + + L H++LS + LLE+ +R + EME+GL TH +A VKMLPT+V +TP Sbjct: 19 FQGSDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTP 78 Query: 521 DGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQ 580 DGTE G+FLALDLGGTNFRVL V+V + VEM N+IYAIP+++M G+G +LFDHI + Sbjct: 79 DGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAE 138 Query: 581 CIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEA 640 C+A+F++ + +K LPLGFTFSFPC Q LDES L+ WTKGFK+SG EG DVV L+++A Sbjct: 139 CLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKA 198 Query: 641 IHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEE 700 I RR +FD+D+VAVVNDTVGTMMTCG++D +CE+GLIVGTGSNACYMEEMR++++VEG+E Sbjct: 199 IQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDE 258 Query: 701 GRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILID 760 GRMC+NMEWGAFGD+G L+D RTEFD +D SLNPGKQ FEKMISGMY+GE+VR IL+ Sbjct: 259 GRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVK 318 Query: 761 FTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVK 820 K LLF G++S L G FETK +S IE + + + R +L LGL+ T +D + Sbjct: 319 MAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATH 378 Query: 821 EVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVK 880 +C +V+ R+A LC A +AAV+ RI+EN+G + L+ T+GVDG++YK HPHFAK +H+TV+ Sbjct: 379 RICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVR 438 Query: 881 DLAPKCDVSFLQSEDGSGKGAALITAVACRI 911 L P CDV FL+SEDGSGKGAA++TAVA R+ Sbjct: 439 RLVPGCDVRFLRSEDGSGKGAAMVTAVAYRL 469 >4FOI-A nrPDB Length = 917 Score = 1437 bits (3721), Expect = 0.0, Method: Compositional matrix adjust. Identities = 672/912 (73%), Positives = 793/912 (86%) Query: 1 MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60 MIA+ LLAY+FTEL DQV+K+D+YLY MRLSDETL++I RFRKEM+ GL +PTA Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120 VKMLPTFVRS PDG+E G+F+ALDLGG++FR+L V+V Q V ME+++Y PE+I+ Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180 GSG+QLFDH+AECL +FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGV Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240 EG DVV L+ KAI++RGD+D +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300 E+RHID+VEGDEGRMCIN EWGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360 Y+GELVRLILVKMAKE LLF G+++PELL G+F T D+S IE K+G+ A+E+L RLG Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420 ++P+ +DCV+ +C IVS RSA+L AATL A+L R+++NKG RLR+T+GV+GS+YK H Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTH 420 Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480 P +++R HKT+RRLVP DVRFL SE GSGKGAAMVTAVAYRLA+QHR ++TL H L+ Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540 D LLEVK+RM+ EME GL K+TH +A VKMLP++V TPDGTE GDFLALDLGGTNFRV Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600 LLV++R+GK VEMHNKIYAIP E+M GTG+ELFDHIV CI+DFL+YMG+KG +PLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660 TFSFPCQQ SLD IL+ WTKGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720 TMMTC +E+P CEVGLIVGTGSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780 RT +D VDE SLN GKQR+EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRG Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840 IFETKFLSQIESD LALLQVRAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900 VVD+IRENRGLD L VTVGVDGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKG Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 Query: 901 AALITAVACRIR 912 AALITAV R+R Sbjct: 901 AALITAVGVRLR 912 Score = 532 bits (1371), Expect = e-151, Method: Compositional matrix adjust. Identities = 247/449 (55%), Positives = 339/449 (75%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 DQ + K L ++LS + L+++ R + EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 Query: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584 KGDF+ALDLGG++FR+L V+V + K V M +++Y P+ ++HG+G +LFDH+ +C+ D Sbjct: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136 Query: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644 F+E +K LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R Sbjct: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196 Query: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 704 ++D ++VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 Query: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMYLGE+VR IL+ K Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316 Query: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 824 GLLF GRI+ L TRG F T +S IE + L + IL LG+E + DD + V+ VCT Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376 Query: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 884 +V+ R+A L A + A+++R+R+N+G L+ TVGV+G+LYK HP +++ H+T++ L P Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLVP 436 Query: 885 KCDVSFLQSEDGSGKGAALITAVACRIRE 913 DV FL SE GSGKGAA++TAVA R+ E Sbjct: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAE 465 >1BG3-A nrPDB Length = 918 Score = 1410 bits (3649), Expect = 0.0, Method: Compositional matrix adjust. Identities = 664/912 (72%), Positives = 791/912 (86%) Query: 1 MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60 MIA+ LLAY+FTEL DQV+K+D+YLY MRLSDE L++I RF+KEM+ GL +PTA+ Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120 VKMLPTFVRS PDG+E G+F+ALDLGG++FR+L V+V Q V ME++IY PE+I+ Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180 GSGTQLFDH+A+CL +FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGV Sbjct: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240 EG DVV L+ KAI++RGD+D +IVAVVNDTVGTMMTCGYDD CE+GLI+GTG+NACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300 E+RHID+VEGDEGRMCIN EWGAFGDDGSL DIRTEFD+E+D GSLNPGKQLFEKM+SGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360 YMGELVRLILVKMAKE LLF G+++PELL G+F T D+S IE +K+GI+ A+E+L RLG Sbjct: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420 ++P+ DCV+ IC IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK H Sbjct: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480 P +++R HKT+RRLVP DVRFL SE G+GKGAAMVTAVAYRLA+QHR ++TL H +LS Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540 L+EVK+R++ EME GL KET++ A VKMLP++V + PDGTE GDFLALDLGGTNFRV Sbjct: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600 LLV++R+GK VEMHNKIY+IP E+M GTGDELFDHIV CI+DFL+YMG+KG +PLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660 TFSFPC Q +LD IL+ WTKGFKA+ CEG DV +LL++A+ RREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720 TMMTC +E+P CE+GLIVGTG+NACYMEEM+NVE+VEG +G+MC+NMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780 RT+FD VDE SLN GKQRFEKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRG Sbjct: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840 IFETKFLSQIESD LALLQVRAILQ LGL STCDDSI+VK VC VV++RAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900 VV++IRENRGLD L VTVGVDGTLYKLHPHF+++MH+TVK+L+PKC VSFL SEDGSGKG Sbjct: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 Query: 901 AALITAVACRIR 912 AALITAV R+R Sbjct: 901 AALITAVGVRLR 912 Score = 522 bits (1344), Expect = e-148, Method: Compositional matrix adjust. Identities = 243/449 (54%), Positives = 337/449 (75%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 DQ + K L ++LS + L+++ R K EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 Query: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584 KGDF+ALDLGG++FR+L V+V + K V M ++IY P+ ++HG+G +LFDH+ C+ D Sbjct: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGD 136 Query: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644 F+E +K LP+GFTFSFPC+Q+ +DE++L+ WTK FKASG EG DVV LL +AI +R Sbjct: 137 FMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 Query: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 704 ++D ++VAVVNDTVGTMMTCG++D CEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 Query: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMY+GE+VR IL+ K Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316 Query: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 824 GLLF GRI+ L TRG F T +S IE D + + IL LG+E + D + V+ +CT Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICT 376 Query: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 884 +V+ R+A L A + A+++R+R+N+G L+ TVGVDG+LYK+HP +++ H+T++ L P Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVP 436 Query: 885 KCDVSFLQSEDGSGKGAALITAVACRIRE 913 DV FL SE G+GKGAA++TAVA R+ E Sbjct: 437 DSDVRFLLSESGTGKGAAMVTAVAYRLAE 465 >3HM8-A nrPDB Length = 445 Score = 611 bits (1575), Expect = e-175, Method: Compositional matrix adjust. Identities = 291/447 (65%), Positives = 365/447 (81%), Gaps = 7/447 (1%) Query: 467 HRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKG 526 R ++TL +L+HDQL V+ +M+ M +GL E ++ ++MLPT+V ATPDG+E+G Sbjct: 3 RRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERG 59 Query: 527 DFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL 586 DFLALDLGGTNFRVLLVRV G V++ ++IY+IP+ V G+G +LFDHIV CI DF Sbjct: 60 DFLALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 115 Query: 587 EYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREE 646 + G+ G SLPLGFTFSFPC+Q LD+ ILL WTKGFKAS CEG+DVV+LL+EAI RR+ Sbjct: 116 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 175 Query: 647 FDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVN 706 +L+VVA+VNDTVGTMM+CG+EDP CE+GLIVGTG+NACYMEE+RNV V G+ GRMC+N Sbjct: 176 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 235 Query: 707 MEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGL 766 MEWGAFGD+G L T FD +VD+ S+NPGKQRFEKMISGMYLGEIVR+IL+ T G+ Sbjct: 236 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 295 Query: 767 LFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVV 826 LFRG+ +RL+TR IF+TKFLS+IESD LAL QVRAIL+ LGL T DD+++V EVC V Sbjct: 296 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 355 Query: 827 ARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKC 886 ++RAAQLCGAG+AAVV++IRENRGL+ L V+VGVDGTLYKLHP F+ ++ TV++LAP+C Sbjct: 356 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 415 Query: 887 DVSFLQSEDGSGKGAALITAVACRIRE 913 V+FLQSEDGSGKGAAL+TAVACR+ + Sbjct: 416 VVTFLQSEDGSGKGAALVTAVACRLAQ 442 Score = 503 bits (1294), Expect = e-142, Method: Compositional matrix adjust. Identities = 243/447 (54%), Positives = 323/447 (72%), Gaps = 7/447 (1%) Query: 22 VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81 +++ L RL+ + L + + RK M KGL ++++MLPTFVR+TPDG+E G+FL Sbjct: 6 LEETLAPFRLNHDQLAAVQAQMRKAMAKGL---RGEASSLRMLPTFVRATPDGSERGDFL 62 Query: 82 ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141 ALDLGGTNFRVL V+VT V++ ++IY+IPE + +GSG QLFDHI +C+ +F K Sbjct: 63 ALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 118 Query: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201 + + LPLGFTFSFPC Q LD+ L++WTKGFK+S EG+DVV+L+R+AI RR ++ Sbjct: 119 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 178 Query: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261 ++VA+VNDTVGTMM+CGY+D CEIGLIVGTG+NACYMEE+R++ V GD GRMCINMEW Sbjct: 179 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 238 Query: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321 GAFGDDGSL + T FD +D S+NPGKQ FEKMISGMY+GE+VR IL+ + +LF Sbjct: 239 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 298 Query: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381 G+ L F+TK +S+IE + +R+ R +L LGL T +D + +CQ VS R Sbjct: 299 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 358 Query: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441 +A LC A +AAV+++I+EN+G E L ++GVDG++YK HP F+ + TVR L P C V Sbjct: 359 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 418 Query: 442 FLRSEDGSGKGAAMVTAVAYRLADQHR 468 FL+SEDGSGKGAA+VTAVA RLA R Sbjct: 419 FLQSEDGSGKGAALVTAVACRLAQLTR 445 >3W0L-A nrPDB Length = 458 Score = 529 bits (1363), Expect = e-150, Method: Compositional matrix adjust. Identities = 247/447 (55%), Positives = 337/447 (75%), Gaps = 2/447 (0%) Query: 20 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79 +VDQ L L +E L + R + EME+GL T+ A+VKMLPT+VRSTPDG+E G+ Sbjct: 7 NEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGD 66 Query: 80 FLALDLGGTNFRVLWVKVTDN--GLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 137 FLALDLGGTNFRV+ VKV ++ G KVE ++++Y+IP D M G+ LFD+IAEC++++ Sbjct: 67 FLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDY 126 Query: 138 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197 +D+ +K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRG Sbjct: 127 LDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 186 Query: 198 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 257 DF++D+VA+VNDTV TM++C Y+DH+CE+GLIVGTG NACYMEEM ++++VEG+EGRMC+ Sbjct: 187 DFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCV 246 Query: 258 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 317 N EWGAFGD G L D R E+D+ +D SLNPG+QL+EKMI G YMGELVRL+L+KM E Sbjct: 247 NTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNEN 306 Query: 318 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 377 LLFGG+ S +L G FET+ +S IE + ++ +L LG+ T DC A C+ Sbjct: 307 LLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACES 366 Query: 378 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 437 VSTR+A +C+A LA +L R+++++ EE LR T+GVDGSVYK HP F + H TV +L G Sbjct: 367 VSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTSG 426 Query: 438 CDVRFLRSEDGSGKGAAMVTAVAYRLA 464 C++ F++SE+GSG+GAA+++AVAY++A Sbjct: 427 CEITFIQSEEGSGRGAALISAVAYKMA 453 Score = 522 bits (1345), Expect = e-148, Method: Compositional matrix adjust. Identities = 259/450 (57%), Positives = 331/450 (73%), Gaps = 5/450 (1%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 DQ+ Q L L + L + RM+ EMERGL ET+ A VKMLPTYV +TPDG+E Sbjct: 5 DQNEVDQ-ILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSE 63 Query: 525 KGDFLALDLGGTNFRVLLVRV---RNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQC 581 GDFLALDLGGTNFRV+LV+V G+W VE +K+Y+IP + M GT + LFD+I +C Sbjct: 64 VGDFLALDLGGTNFRVMLVKVGEDLEGQWK-VETKHKMYSIPVDAMTGTAEMLFDYIAEC 122 Query: 582 IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAI 641 I+D+L+ MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI Sbjct: 123 ISDYLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 182 Query: 642 HRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEG 701 RR +F++DVVA+VNDTV TM++C +ED HCEVGLIVGTG NACYMEEM NVELVEGEEG Sbjct: 183 KRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEG 242 Query: 702 RMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDF 761 RMCVN EWGAFGD G L+DFR E+D VDE SLNPG+Q +EKMI G Y+GE+VR +LI Sbjct: 243 RMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKM 302 Query: 762 TKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKE 821 LLF G SE+LKTRG FET+F+SQIE+D Q IL+ LG+++T D V+ Sbjct: 303 VNENLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRL 362 Query: 822 VCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKD 881 C V+ RAA +C AG+A +++R+R++R + L++TVGVDG++YKLHP F H TV Sbjct: 363 ACESVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLK 422 Query: 882 LAPKCDVSFLQSEDGSGKGAALITAVACRI 911 L C+++F+QSE+GSG+GAALI+AVA ++ Sbjct: 423 LTSGCEITFIQSEEGSGRGAALISAVAYKM 452 >4DCH-A nrPDB Length = 473 Score = 518 bits (1335), Expect = e-147, Method: Compositional matrix adjust. Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%) Query: 471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 530 ++ L QL + L +V RRM+ EM+RGL ETH A VKMLPTYV +TP+G+E GDFL+ Sbjct: 17 EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 76 Query: 531 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 588 LDLGGTNFRV+LV+V G+ G V+ +++Y+IP++ M GT + LFD+I +CI+DFL+ Sbjct: 77 LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 136 Query: 589 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 648 MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+ Sbjct: 137 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 196 Query: 649 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 708 +DVVA+VNDTV TM++C +ED CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E Sbjct: 197 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 256 Query: 709 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 768 WGAFGD+G LD+F E+D VDE S NPG+Q +EK+I G Y+GE+VR +L+ LLF Sbjct: 257 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 316 Query: 769 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 828 G SE+L+TRG FET+F+SQ+ESD Q+ IL LGL + D IV+ C V+ Sbjct: 317 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 376 Query: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888 RAA +C AG+A V++R+RE+R D +++TVGVDG++YKLHP F + H +V+ L P C++ Sbjct: 377 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 436 Query: 889 SFLQSEDGSGKGAALITAVACR 910 +F++SE+GSG+GAAL++AVAC+ Sbjct: 437 TFIESEEGSGRGAALVSAVACK 458 Score = 513 bits (1320), Expect = e-145, Method: Compositional matrix adjust. Identities = 242/447 (54%), Positives = 340/447 (76%), Gaps = 2/447 (0%) Query: 20 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79 +KV+Q L +L +E L ++ +R +KEM++GL TH A+VKMLPT+VRSTP+G+E G+ Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 80 FLALDLGGTNFRVLWVKVTD--NGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 137 FL+LDLGGTNFRV+ VKV + G V+ ++Q+Y+IPED M G+ LFD+I+EC+++F Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 Query: 138 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197 +DK Q+K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRG Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 Query: 198 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 257 DF++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+ Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 Query: 258 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 317 N EWGAFGD G L++ E+D+ +D S NPG+QL+EK+I G YMGELVRL+L+++ E Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 Query: 318 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 377 LLF G+ S +L G FET+ +S +E + ++ +L LGL P+ DC R C+ Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 Query: 378 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 437 VSTR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 Query: 438 CDVRFLRSEDGSGKGAAMVTAVAYRLA 464 C++ F+ SE+GSG+GAA+V+AVA + A Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKA 460 >1BDG-A nrPDB Length = 451 Score = 386 bits (991), Expect = e-107, Method: Compositional matrix adjust. Identities = 213/443 (48%), Positives = 283/443 (63%), Gaps = 15/443 (3%) Query: 474 LEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDL 533 L+ LS E+ RM M GL K T+ + +KM P+YV TP+GTE G+FLALDL Sbjct: 16 LKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLALDL 75 Query: 534 GGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKG 593 GGTN+RVL V + GK + + Y IP E M G+G ELF +I + +ADFLE GMK Sbjct: 76 GGTNYRVLSVTLE-GKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLENNGMKD 134 Query: 594 VSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVA 653 LGFTFSFPC Q L + L++WTKGF A G EG +V LL+ + +RE ++ VA Sbjct: 135 KKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKRE-LNVKCVA 193 Query: 654 VVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG-EEGRMCVNMEWGAF 712 VVNDTVGT+ +C EDP C VGLIVGTG+N Y+E+ VEL++G +E + +N EWGAF Sbjct: 194 VVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVVINTEWGAF 253 Query: 713 GDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRI 772 G+ G LD +RT+FD ++D SL+PGKQ +EKM+SGMYLGE+VR+I++ ++ +LFRG + Sbjct: 254 GEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKILFRGDL 313 Query: 773 SERLKTRGIFETKFLSQIESDCLALLQVRAIL----QHLGLESTCDDSIIVKEVCTVVAR 828 ERLK R T++L+ +E D LL + H+ + D+ IV+ C +V + Sbjct: 314 PERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNR-IVRYACEMVVK 372 Query: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888 RAA L GAG+A ++ RI NR +VTVGVDG+LYK HP F + M + V L PK Sbjct: 373 RAAYLAGAGIACILRRI--NRS----EVTVGVDGSLYKFHPKFCERMTDMVDKLKPKNTR 426 Query: 889 SFLQ-SEDGSGKGAALITAVACR 910 L+ SEDGSGKGAA I A R Sbjct: 427 FCLRLSEDGSGKGAAAIAASCTR 449 Score = 352 bits (902), Expect = 6e-97, Method: Compositional matrix adjust. Identities = 197/449 (43%), Positives = 281/449 (62%), Gaps = 15/449 (3%) Query: 20 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79 +KV + L LS EI R + M GL +T+ +++KM P++V TP+GTE G Sbjct: 10 EKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGN 69 Query: 80 FLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMD 139 FLALDLGGTN+RVL V + G + ++ + Y IP + M GSGT+LF +IAE LA+F++ Sbjct: 70 FLALDLGGTNYRVLSVTLEGKG-KSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLE 128 Query: 140 KLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDF 199 +KDKK LGFTFSFPC Q L + LV WTKGF + GVEG +V L++ + +R + Sbjct: 129 NNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR-EL 187 Query: 200 DIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG-DEGRMCIN 258 ++ VAVVNDTVGT+ +C +D C +GLIVGTG+N Y+E+ +++++G E + IN Sbjct: 188 NVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVVIN 247 Query: 259 MEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEEL 318 EWGAFG+ G L+ RT+FD+ +D+ SL+PGKQL+EKM+SGMY+GELVR I+V + ++++ Sbjct: 248 TEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKI 307 Query: 319 LFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLD-PTQE--DCVATHRIC 375 LF G L L T+ ++D+E + + ++ L P E D C Sbjct: 308 LFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVRYAC 367 Query: 376 QIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV 435 ++V R+A L A +A +L+RI R T+GVDGS+YK HP F +R+ V +L Sbjct: 368 EMVVKRAAYLAGAGIACILRRIN------RSEVTVGVDGSLYKFHPKFCERMTDMVDKLK 421 Query: 436 PGCDVRF-LR-SEDGSGKGAAMVTAVAYR 462 P + RF LR SEDGSGKGAA + A R Sbjct: 422 PK-NTRFCLRLSEDGSGKGAAAIAASCTR 449 >5ZQT-A nrPDB Length = 473 Score = 272 bits (696), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 175/461 (37%), Positives = 261/461 (56%), Gaps = 33/461 (7%) Query: 19 VQKVDQYLYHMRLSDETLL--EISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76 +++V+Q R S T L I+ +EME+GL A H A +KML ++V + P G E Sbjct: 16 IEEVEQ-----RFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDE 68 Query: 77 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136 HG F ALDLGGTNFRV+ V++ + V + + AIP +M G+ +LFD IA L + Sbjct: 69 HGLFYALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELES 128 Query: 137 FMDKLQIKDKKLP------LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIR 190 F+ K + +D LP LGFTFSFP HQT + L+ WTKGF +G G DVVA + Sbjct: 129 FV-KTEGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELS 187 Query: 191 KAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG 250 +A++R+G D+ + A+VNDTVGT+ Y D++ +I+GTG+NA Y+E I G Sbjct: 188 RAMERQG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTG 246 Query: 251 ---DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVR 307 G M INMEWG F + R+++D +D SLNPG+Q++EKMISGMY+GE+VR Sbjct: 247 LLPRSGNMVINMEWGNFKSE---RLPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVR 303 Query: 308 LILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGL-DPT 364 IL+K+A + LFG + +L T D+S + + K ++ LG+ D + Sbjct: 304 RILLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTS 363 Query: 365 QEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENK----GEERLRSTIGVDGSVYKKH 420 E T +C +V+ R A L AA + +L+++ ++ G ++ R+ I +DG +Y+ + Sbjct: 364 LEARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHY 423 Query: 421 PHFAKRLHKTVRRLV---PGCDVRFLRSEDGSGKGAAMVTA 458 F L T+ L+ V + DGSG GAA++ A Sbjct: 424 KKFRTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 464 Score = 260 bits (665), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 169/440 (38%), Positives = 231/440 (52%), Gaps = 36/440 (8%) Query: 491 MKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKW 550 M EMERGL + HA P+KML +YV P G E G F ALDLGGTNFRV+ V++ + Sbjct: 37 MVEEMERGLRADPHA--PLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREK 94 Query: 551 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMG-----MKGVSLPLGFTFSFP 605 V + AIP +M GT ELFD I + F++ G +G LGFTFSFP Sbjct: 95 RVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTEGEDFHLPEGRQRELGFTFSFP 154 Query: 606 CQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTC 665 Q S+ L+KWTKGF +G GEDVV L A+ R+ D+ V A+VNDTVGT+ Sbjct: 155 VHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAM-ERQGLDMKVTALVNDTVGTLAGG 213 Query: 666 GFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGDNGCLDDFR 722 + D +I+GTG+NA Y+E + G G M +NMEWG F R Sbjct: 214 RYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSERLP---R 270 Query: 723 TEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIF 782 +++D A+D SLNPG+Q +EKMISGMYLGEIVR IL+ LF + +L+ R I Sbjct: 271 SDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFIL 330 Query: 783 ETKFLSQIESDCLALLQVRAILQHLG---------LESTCDDSIIVKEVCTVVARRAAQL 833 T +S + D L+HLG +++ + I VC +VA R A+L Sbjct: 331 RTPDMSAMHHDT------SHDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARL 384 Query: 834 CGAGMAAVVDRIRENR----GLDALKVTVGVDGTLYKLHPHFAKVMHETVKDL---APKC 886 AG+ ++ ++ +R G + + +DG LY+ + F + T+ DL Sbjct: 385 AAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAAS 444 Query: 887 DVSFLQSEDGSGKGAALITA 906 V + DGSG GAAL+ A Sbjct: 445 SVVVKLANDGSGIGAALLAA 464 >3O1W-A nrPDB Length = 485 Score = 272 bits (696), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 161/457 (35%), Positives = 261/457 (57%), Gaps = 33/457 (7%) Query: 479 LSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNF 538 +S +++ + + E+++GLSK+ + M+P +V P G E GDFLALDLGGTN Sbjct: 36 VSSEKMRSIVKHFISELDKGLSKK---GGNIPMIPGWVVEYPTGKETGDFLALDLGGTNL 92 Query: 539 RVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVS--L 596 RV+LV++ G NK Y +P + GT ++L+ I +C+ +F++ GVS L Sbjct: 93 RVVLVKL-GGNHDFDTTQNK-YRLPDHLRTGTSEQLWSFIAKCLKEFVDEWYPDGVSEPL 150 Query: 597 PLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVN 656 PLGFTFS+P Q ++ +L +WTKGF G EG DVV +L+E I + ++VVA++N Sbjct: 151 PLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKLN-IPINVVALIN 209 Query: 657 DTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG-------EEGRMCVNMEW 709 DT GT++ + DP ++G+I+GTG N Y + + +E +EG + M +N E+ Sbjct: 210 DTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPDSPMAINCEY 269 Query: 710 GAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFR 769 G+F DN L RT++DV +DE S PG+Q FEKM SG YLGEI+R +L+D G +F+ Sbjct: 270 GSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFK 328 Query: 770 GRISERLKTRGIFETKFLSQIESDCLALLQVRAIL--QHLGLESTCDDSIIVKEVCTVVA 827 + +LK + +T + S+IE D L+ L +L +E+T + +++++ +V Sbjct: 329 DQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVERKLIRKLAELVG 388 Query: 828 RRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCD 887 RAA+L G++A+ D+ RG + DG+++ +P + + + +KD+ D Sbjct: 389 TRAARLTVCGVSAICDK----RGYKT--AHIAADGSVFNRYPGYKEKAAQALKDIY-NWD 441 Query: 888 V--------SFLQSEDGSGKGAALITAVACRIREAGQ 916 V + +EDGSG GAA+I + + AG+ Sbjct: 442 VEKMEDHPIQLVAAEDGSGVGAAIIACLTQKRLAAGK 478 Score = 233 bits (593), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 145/450 (32%), Positives = 246/450 (54%), Gaps = 31/450 (6%) Query: 31 LSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNF 90 +S E + I K F E++KGL + + M+P +V P G E G+FLALDLGGTN Sbjct: 36 VSSEKMRSIVKHFISELDKGL---SKKGGNIPMIPGWVVEYPTGKETGDFLALDLGGTNL 92 Query: 91 RVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIK--DKKL 148 RV+ VK+ N + Y +P+ + G+ QL+ IA+CL F+D+ + L Sbjct: 93 RVVLVKLGGN--HDFDTTQNKYRLPDHLRTGTSEQLWSFIAKCLKEFVDEWYPDGVSEPL 150 Query: 149 PLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVN 208 PLGFTFS+P Q K++ L WTKGF GVEG DVV ++++ I++ + I++VA++N Sbjct: 151 PLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL-NIPINVVALIN 209 Query: 209 DTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVE-------GDEGRMCINMEW 261 DT GT++ Y D ++G+I+GTG N Y + + I+ +E G + M IN E+ Sbjct: 210 DTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPDSPMAINCEY 269 Query: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321 G+F D+ L RT++D ID S PG+Q FEKM SG Y+GE++RL+L+ + +F Sbjct: 270 GSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFK 328 Query: 322 GKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVL-MRLGLDPTQEDCVATHRICQIVS 379 + +L +T S IE + + + ++ L ++ T + ++ ++V Sbjct: 329 DQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVERKLIRKLAELVG 388 Query: 380 TRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRL----- 434 TR+A L ++A+ + +G + + I DGSV+ ++P + ++ + ++ + Sbjct: 389 TRAARLTVCGVSAICDK----RGYK--TAHIAADGSVFNRYPGYKEKAAQALKDIYNWDV 442 Query: 435 --VPGCDVRFLRSEDGSGKGAAMVTAVAYR 462 + ++ + +EDGSG GAA++ + + Sbjct: 443 EKMEDHPIQLVAAEDGSGVGAAIIACLTQK 472 >3B8A-X nrPDB Length = 485 Score = 249 bits (636), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 157/450 (34%), Positives = 259/450 (57%), Gaps = 35/450 (7%) Query: 479 LSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNF 538 + + L +V + E+ +GL+K+ + M+P +V P G E G++LA+DLGGTN Sbjct: 36 VDSETLRKVVKHFIDELNKGLTKK---GGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNL 92 Query: 539 RVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTG--DELFDHIVQCIADFL---EYMGMKG 593 RV+LV++ + Y +P + M T +EL+ I + DF+ E + K Sbjct: 93 RVVLVKLSGNH--TFDTTQSKYKLPHD-MRTTKHQEELWSFIADSLKDFMVEQELLNTKD 149 Query: 594 VSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVA 653 +LPLGFTFS+P QN ++E IL +WTKGF EG DVV LL+ I +RE +++VA Sbjct: 150 -TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRE-LPIEIVA 207 Query: 654 VVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGE-------EGRMCVN 706 ++NDTVGT++ + DP ++G+I GTG N + + + ++E +EG+ M +N Sbjct: 208 LINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAIN 267 Query: 707 MEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGL 766 E+G+F DN L RT++DVAVDE S PG+Q FEKM SG YLGE++R +L++ ++GL Sbjct: 268 CEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGL 326 Query: 767 LFRGRISERLKTRGIFETKFLSQIESDCLALLQ-VRAILQH-LGLESTCDDSIIVKEVCT 824 + + + +LK I +T + ++IE D L+ I Q G+++T + +++ +C Sbjct: 327 MLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCE 386 Query: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDL-- 882 ++ RAA+L G+AA+ + G + DG++Y +P F + + ++D+ Sbjct: 387 LIGTRAARLAVCGIAAICQKRGYKTG------HIAADGSVYNKYPGFKEAAAKGLRDIYG 440 Query: 883 ----APKCDVSFLQSEDGSGKGAALITAVA 908 A K ++ + +EDGSG GAA+I A++ Sbjct: 441 WTGDASKDPITIVPAEDGSGAGAAVIAALS 470 Score = 230 bits (586), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 162/452 (35%), Positives = 246/452 (54%), Gaps = 45/452 (9%) Query: 34 ETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVL 93 ETL ++ K F E+ KGL T + M+P +V P G E G +LA+DLGGTN RV+ Sbjct: 39 ETLRKVVKHFIDELNKGL---TKKGGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVV 95 Query: 94 WVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQ--LFDHIAECLANFMDKLQIKDKK--LP 149 VK++ N + Y +P D MR + Q L+ IA+ L +FM + ++ + K LP Sbjct: 96 LVKLSGN--HTFDTTQSKYKLPHD-MRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLP 152 Query: 150 LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVND 209 LGFTFS+P Q K++E L WTKGF VEG DVV L++ I +R + I+IVA++ND Sbjct: 153 LGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR-ELPIEIVALIND 211 Query: 210 TVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG-------DEGRMCINMEWG 262 TVGT++ Y D ++G+I GTG N + + + I+ +EG M IN E+G Sbjct: 212 TVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYG 271 Query: 263 AFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG- 321 +F D+ L RT++D +D S PG+Q FEKM SG Y+GEL+RL+L+++ ++ L+ Sbjct: 272 SF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKD 330 Query: 322 ---GKL-SPELLNT---GRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRI 374 KL P +++T R E ++E D +K G+ T + R+ Sbjct: 331 QDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQK------DFGVKTTLPERKLIRRL 384 Query: 375 CQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRL 434 C+++ TR+A L +AA+ Q+ G I DGSVY K+P F + K +R + Sbjct: 385 CELIGTRAARLAVCGIAAICQKRGYKTGH------IAADGSVYNKYPGFKEAAAKGLRDI 438 Query: 435 VPGC------DVRFLRSEDGSGKGAAMVTAVA 460 + + +EDGSG GAA++ A++ Sbjct: 439 YGWTGDASKDPITIVPAEDGSGAGAAVIAALS 470 >1IG8-A nrPDB Length = 486 Score = 244 bits (624), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 144/437 (32%), Positives = 242/437 (55%), Gaps = 31/437 (7%) Query: 463 LADQHRARQKTLEHLQ----LSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCA 518 +AD + + +E+ + + + L V + E+E+GLSK+ + M+P +V Sbjct: 16 MADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMD 72 Query: 519 TPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGT--GDELFD 576 P G E GDFLA+DLGGTN RV+LV++ + + Y +P + M T DEL++ Sbjct: 73 FPTGKESGDFLAIDLGGTNLRVVLVKLGGDR--TFDTTQSKYRLP-DAMRTTQNPDELWE 129 Query: 577 HIVQCIADFLEYMGMKGVS--LPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVV 634 I + F++ +G+S +PLGFTFSFP QN ++E IL +WTKGF E DVV Sbjct: 130 FIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVV 189 Query: 635 TLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVE 694 +L++ I +R ++VVA++NDT GT++ + DP ++G+I GTG N Y + ++E Sbjct: 190 PMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIE 248 Query: 695 LVEGE-------EGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISG 747 ++G+ M +N E+G+F DN + RT++D+ +DE S PG+Q FEKM SG Sbjct: 249 KLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSG 307 Query: 748 MYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQ-VRAILQH 806 YLGEI+R L+D K+G +F+ + + + +T + ++IE D L+ + Q+ Sbjct: 308 YYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN 367 Query: 807 -LGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLY 865 G+ +T + +++ + ++ RAA+L G+AA+ + G + DG++Y Sbjct: 368 EFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVY 421 Query: 866 KLHPHFAKVMHETVKDL 882 +P F + +KD+ Sbjct: 422 NRYPGFKEKAANALKDI 438 Score = 227 bits (578), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 145/435 (33%), Positives = 234/435 (53%), Gaps = 39/435 (8%) Query: 19 VQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHG 78 +Q+++ + + ETL ++K F E+EKGL + + M+P +V P G E G Sbjct: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESG 80 Query: 79 EFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGT--QLFDHIAECLAN 136 +FLA+DLGGTN RV+ VK+ G + + Y +P D MR + +L++ IA+ L Sbjct: 81 DFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSLKA 137 Query: 137 FMDK--LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQ 194 F+D+ Q + +PLGFTFSFP Q K++E L WTKGF +E DVV +++K I Sbjct: 138 FIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 Query: 195 RRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---- 250 +R + I++VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 198 KR-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSD 256 Query: 251 ---DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVR 307 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG Y+GE++R Sbjct: 257 DIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILR 315 Query: 308 LILVKMAKEELLFGGK-LS----PELLNT---GRFETKDISDIEGEKDGIRKAREVLMRL 359 L L+ M K+ +F + LS P +++T R E ++E D + Sbjct: 316 LALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN------EF 369 Query: 360 GLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKK 419 G++ T ++ R+ +++ R+A L +AA+ Q+ G I DGSVY + Sbjct: 370 GINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNR 423 Query: 420 HPHFAKRLHKTVRRL 434 +P F ++ ++ + Sbjct: 424 YPGFKEKAANALKDI 438 >4QS9-A nrPDB Length = 474 Score = 244 bits (622), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 157/440 (35%), Positives = 237/440 (53%), Gaps = 22/440 (5%) Query: 483 QLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLL 542 +L +V M VEM GL+ + + +KML +YV P G EKG F ALDLGGTNFRV+ Sbjct: 32 KLRQVADAMTVEMHAGLASD--GGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMR 89 Query: 543 VRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL-----EYMGMKGVSLP 597 V + + V+ + +IP +M G DELF+ I + +A F+ ++ +G Sbjct: 90 VLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRE 149 Query: 598 LGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVND 657 LGFTF+FP +Q SL L+KWTKGF G+DVV L +A+ R D+ + A+VND Sbjct: 150 LGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAALVND 208 Query: 658 TVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGAFGD 714 TVGT+ + +P +I+GTG+NA Y+E + G + G M +NMEWG F Sbjct: 209 TVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRS 268 Query: 715 NGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISE 774 + TEFD +D SLNPG+Q EK+ISGMYLGEI+R +L+ + F + Sbjct: 269 SHLP---LTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPS 325 Query: 775 RLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGLESTC-DDSIIVKEVCTVVARRAA 831 +L+ I T +S + +D L++ I L + +T +V +C ++A R A Sbjct: 326 KLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGA 385 Query: 832 QLCGAGMAAVVDRIRENRGLD--ALKVTVGVDGTLYKLHPHFAKVMHETVKDL---APKC 886 +L AG+ ++ ++ + D K + +DG L++ + F++ M ++K+L Sbjct: 386 RLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASG 445 Query: 887 DVSFLQSEDGSGKGAALITA 906 V S DGSG GAAL+ A Sbjct: 446 SVEVTHSNDGSGIGAALLAA 465 Score = 244 bits (622), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 160/442 (36%), Positives = 241/442 (54%), Gaps = 28/442 (6%) Query: 36 LLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWV 95 L +++ EM GL + + +KML ++V + P G E G F ALDLGGTNFRV+ V Sbjct: 33 LRQVADAMTVEMHAGLASDG--GSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRV 90 Query: 96 KVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLP------ 149 + + V+ E + +IP +M G +LF+ IAE LA F+ + +D LP Sbjct: 91 LLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-ATECEDFHLPEGRQRE 149 Query: 150 LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVND 209 LGFTF+FP QT L L+ WTKGF G+DVV + KA++R G D+ I A+VND Sbjct: 150 LGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVND 208 Query: 210 TVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DEGRMCINMEWGAFGD 266 TVGT+ Y + + +I+GTG+NA Y+E I G G M INMEWG F Sbjct: 209 TVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF-- 266 Query: 267 DGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSP 326 S + TEFD +D SLNPG+Q+ EK+ISGMY+GE++R +L+KMA++ FG + Sbjct: 267 -RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPS 325 Query: 327 ELLNTGRFETKDISDIEGE-----KDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381 +L T +S + + K K +++L V + +C I++TR Sbjct: 326 KLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVIS--LCNIIATR 383 Query: 382 SASLCAATLAAVLQRIKEN--KGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV---P 436 A L AA + +L+++ + K EE +S I +DG +++ + F++ + +++ L+ Sbjct: 384 GARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEA 443 Query: 437 GCDVRFLRSEDGSGKGAAMVTA 458 V S DGSG GAA++ A Sbjct: 444 SGSVEVTHSNDGSGIGAALLAA 465 >2YHX-A nrPDB Length = 457 Score = 41.6 bits (96), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/184 (21%), Positives = 72/184 (39%), Gaps = 16/184 (8%) Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIY------AI 114 + M+P +V G + G FLA+ +GG + V+ + + + + AI Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAI 103 Query: 115 PEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKG 174 P D+ + A + +PLGFTF + + + + Sbjct: 104 PSDLWG-------NXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 175 FKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGS 234 F + + +++ + A GD VA + D+ G + Y D ++G+I G+G Sbjct: 157 FSLAXLX--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 235 NACY 238 NA Y Sbjct: 214 NAAY 217 Score = 37.4 bits (85), Expect = 0.029, Method: Compositional matrix adjust. Identities = 37/184 (20%), Positives = 73/184 (39%), Gaps = 16/184 (8%) Query: 509 VKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIY------AI 562 + M+P +V G + G FLA+ +GG + V+L+ + + + + AI Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAI 103 Query: 563 PQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKG 622 P ++ G+ + S+PLGFTF + + + + Sbjct: 104 PSDLW---GNXAXSNAAFS----SXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 623 FKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGS 682 F + +++ + A + VA + D+ G + + D ++G+I G+G Sbjct: 157 FSLAXL--XKLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 683 NACY 686 NA Y Sbjct: 214 NAAY 217 >1HKG-A nrPDB Length = 457 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/184 (21%), Positives = 73/184 (39%), Gaps = 16/184 (8%) Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYA------I 114 + M+P +V G++ G FLA+ +GG + V+ + + + + A I Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 115 PEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKG 174 P D+ + A + +PLGFTF + + + + Sbjct: 104 PSDLWG-------NXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 175 FKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGS 234 F + + +++ + A GD VA + D+ G + Y D ++G+I G+G Sbjct: 157 FSLAXLX--KLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 235 NACY 238 NA Y Sbjct: 214 NAAY 217 Score = 37.0 bits (84), Expect = 0.039, Method: Compositional matrix adjust. Identities = 37/184 (20%), Positives = 74/184 (40%), Gaps = 16/184 (8%) Query: 509 VKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIY------AI 562 + M+P +V G++ G FLA+ +GG + V+L+ + + + + AI Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 563 PQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKG 622 P ++ G+ + S+PLGFTF + + + + Sbjct: 104 PSDLW---GNXAXSNAAFS----SXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 623 FKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGS 682 F + +++ + A + VA + D+ G + + D ++G+I G+G Sbjct: 157 FSLAXL--XKLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 683 NACY 686 NA Y Sbjct: 214 NAAY 217 >4LS7-A nrPDB Length = 426 Score = 30.0 bits (66), Expect = 5.3, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 12/115 (10%) Query: 285 SLNP----GKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFE----- 335 S NP + F+K G MGE +I+++ + L G K+ E++ G Sbjct: 223 STNPDPKTASRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHI 282 Query: 336 TKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATL 390 T D EG G R +E + G+ P + D + H + + ++ T+ Sbjct: 283 TAPAQDGEG---GARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTV 334 >4N2M-A nrPDB Length = 690 Score = 29.6 bits (65), Expect = 5.7, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 19/32 (59%) Query: 786 FLSQIESDCLALLQVRAILQHLGLESTCDDSI 817 F Q+E +C + VR +L+ LGLE T D I Sbjct: 625 FGPQVEEECCLEMHVRGLLEPLGLECTFIDDI 656 >1WDI-A nrPDB Length = 345 Score = 29.6 bits (65), Expect = 6.5, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 34/78 (43%), Gaps = 5/78 (6%) Query: 41 KRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDN 100 +R++ + G+ PTA + P + + FL L +G FR + Sbjct: 167 ERYQTVYARRPGSVAAPTAGLHFTPELLERLREMGVELRFLTLHVGPGTFRPV-----KG 221 Query: 101 GLQKVEMENQIYAIPEDI 118 +K EM + YAIPE++ Sbjct: 222 DPEKHEMHAEPYAIPEEV 239 >5CY4-A nrPDB Length = 196 Score = 29.3 bits (64), Expect = 8.2, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%) Query: 16 HDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGL 51 H + +++QY ++ L T+ E+SKR+R E+ GL Sbjct: 126 HRLMPELEQYFHYRNLDVSTVKELSKRWRPEIMSGL 161 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4FOI-A nrPDB 1402 0.0 5HFU-A nrPDB 1393 0.0 1BG3-A nrPDB 1391 0.0 3W0L-A nrPDB 651 0.0 3HM8-A nrPDB 639 0.0 4DCH-A nrPDB 637 0.0 3O1W-A nrPDB 578 e-165 1BDG-A nrPDB 574 e-164 1IG8-A nrPDB 554 e-158 3B8A-X nrPDB 542 e-154 5ZQT-A nrPDB 536 e-152 4QS9-A nrPDB 526 e-149 2YHX-A nrPDB 196 4e-50 Sequences not found previously or not previously below threshold: 1HKG-A nrPDB 190 2e-48 1R6M-A nrPDB 34 0.32 3ZYM-A nrPDB 33 0.55 3ZYK-A nrPDB 32 1.4 2BWY-A nrPDB 31 2.1 5ZI1-A nrPDB 31 3.2 3BPV-A nrPDB 30 4.3 5X0B-A nrPDB 30 4.9 5SVC-B nrPDB 30 5.5 6G5O-A nrPDB 30 6.3 1WZC-A nrPDB 30 6.8 4JOD-A nrPDB 29 9.4 >4FOI-A nrPDB Length = 917 Score = 1402 bits (3628), Expect = 0.0, Method: Composition-based stats. Identities = 672/912 (73%), Positives = 793/912 (86%) Query: 1 MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60 MIA+ LLAY+FTEL DQV+K+D+YLY MRLSDETL++I RFRKEM+ GL +PTA Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120 VKMLPTFVRS PDG+E G+F+ALDLGG++FR+L V+V Q V ME+++Y PE+I+ Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180 GSG+QLFDH+AECL +FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGV Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240 EG DVV L+ KAI++RGD+D +IVAVVNDTVGTMMTCGYDD +CE+GLI+GTG+NACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300 E+RHID+VEGDEGRMCIN EWGAFGDDGSL DIRTEFD+EID GSLNPGKQLFEKM+SGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360 Y+GELVRLILVKMAKE LLF G+++PELL G+F T D+S IE K+G+ A+E+L RLG Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420 ++P+ +DCV+ +C IVS RSA+L AATL A+L R+++NKG RLR+T+GV+GS+YK H Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTH 420 Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480 P +++R HKT+RRLVP DVRFL SE GSGKGAAMVTAVAYRLA+QHR ++TL H L+ Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540 D LLEVK+RM+ EME GL K+TH +A VKMLP++V TPDGTE GDFLALDLGGTNFRV Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600 LLV++R+GK VEMHNKIYAIP E+M GTG+ELFDHIV CI+DFL+YMG+KG +PLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660 TFSFPCQQ SLD IL+ WTKGFKA+ C G DVVTLL++AI RREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720 TMMTC +E+P CEVGLIVGTGSNACYMEEM+NVE+VEG++G+MC+NMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780 RT +D VDE SLN GKQR+EKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRG Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840 IFETKFLSQIESD LALLQVRAILQ LGL STCDDSI+VK VC VV+RRAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900 VVD+IRENRGLD L VTVGVDGTLYKLHPHF+++MH+TVK+L+PKC+VSFL SEDGSGKG Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 Query: 901 AALITAVACRIR 912 AALITAV R+R Sbjct: 901 AALITAVGVRLR 912 Score = 544 bits (1401), Expect = e-155, Method: Composition-based stats. Identities = 247/449 (55%), Positives = 339/449 (75%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 DQ + K L ++LS + L+++ R + EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 Query: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584 KGDF+ALDLGG++FR+L V+V + K V M +++Y P+ ++HG+G +LFDH+ +C+ D Sbjct: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGD 136 Query: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644 F+E +K LP+GFTFSFPCQQ+ +DE+IL+ WTK FKASG EG DVV LL +AI +R Sbjct: 137 FMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKR 196 Query: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 704 ++D ++VAVVNDTVGTMMTCG++D HCEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 Query: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMYLGE+VR IL+ K Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKE 316 Query: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 824 GLLF GRI+ L TRG F T +S IE + L + IL LG+E + DD + V+ VCT Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCT 376 Query: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 884 +V+ R+A L A + A+++R+R+N+G L+ TVGV+G+LYK HP +++ H+T++ L P Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTHPQYSRRFHKTLRRLVP 436 Query: 885 KCDVSFLQSEDGSGKGAALITAVACRIRE 913 DV FL SE GSGKGAA++TAVA R+ E Sbjct: 437 DSDVRFLLSESGSGKGAAMVTAVAYRLAE 465 >5HFU-A nrPDB Length = 923 Score = 1393 bits (3606), Expect = 0.0, Method: Composition-based stats. Identities = 901/901 (100%), Positives = 901/901 (100%) Query: 17 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 76 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE Sbjct: 23 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 77 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 136 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 137 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR Sbjct: 143 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 202 Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 256 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC Sbjct: 203 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 262 Query: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE Sbjct: 263 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 322 Query: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 376 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ Sbjct: 323 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 382 Query: 377 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 436 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP Sbjct: 383 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 442 Query: 437 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 496 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 502 Query: 497 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 556 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH Sbjct: 503 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 562 Query: 557 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 616 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL Sbjct: 563 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 622 Query: 617 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 676 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL Sbjct: 623 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 682 Query: 677 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 736 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP Sbjct: 683 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 737 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 796 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 797 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 856 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV Sbjct: 803 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 862 Query: 857 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ 916 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ Sbjct: 863 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIREAGQ 922 Query: 917 R 917 R Sbjct: 923 R 923 Score = 588 bits (1516), Expect = e-168, Method: Composition-based stats. Identities = 266/450 (59%), Positives = 350/450 (77%) Query: 464 ADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGT 523 +DQ + + L H++LS + LLE+ +R + EME+GL TH +A VKMLPT+V +TPDGT Sbjct: 22 SDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGT 81 Query: 524 EKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIA 583 E G+FLALDLGGTNFRVL V+V + VEM N+IYAIP+++M G+G +LFDHI +C+A Sbjct: 82 EHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLA 141 Query: 584 DFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHR 643 +F++ + +K LPLGFTFSFPC Q LDES L+ WTKGFK+SG EG DVV L+++AI R Sbjct: 142 NFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 201 Query: 644 REEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRM 703 R +FD+D+VAVVNDTVGTMMTCG++D +CE+GLIVGTGSNACYMEEMR++++VEG+EGRM Sbjct: 202 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM 261 Query: 704 CVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTK 763 C+NMEWGAFGD+G L+D RTEFD +D SLNPGKQ FEKMISGMY+GE+VR IL+ K Sbjct: 262 CINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAK 321 Query: 764 RGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVC 823 LLF G++S L G FETK +S IE + + + R +L LGL+ T +D + +C Sbjct: 322 EELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRIC 381 Query: 824 TVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLA 883 +V+ R+A LC A +AAV+ RI+EN+G + L+ T+GVDG++YK HPHFAK +H+TV+ L Sbjct: 382 QIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV 441 Query: 884 PKCDVSFLQSEDGSGKGAALITAVACRIRE 913 P CDV FL+SEDGSGKGAA++TAVA R+ + Sbjct: 442 PGCDVRFLRSEDGSGKGAAMVTAVAYRLAD 471 >1BG3-A nrPDB Length = 918 Score = 1391 bits (3601), Expect = 0.0, Method: Composition-based stats. Identities = 664/912 (72%), Positives = 791/912 (86%) Query: 1 MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAA 60 MIA+ LLAY+FTEL DQV+K+D+YLY MRLSDE L++I RF+KEM+ GL +PTA+ Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMR 120 VKMLPTFVRS PDG+E G+F+ALDLGG++FR+L V+V Q V ME++IY PE+I+ Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 Query: 121 GSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGV 180 GSGTQLFDH+A+CL +FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGV Sbjct: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 Query: 181 EGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYME 240 EG DVV L+ KAI++RGD+D +IVAVVNDTVGTMMTCGYDD CE+GLI+GTG+NACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 Query: 241 EMRHIDMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGM 300 E+RHID+VEGDEGRMCIN EWGAFGDDGSL DIRTEFD+E+D GSLNPGKQLFEKM+SGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLG 360 YMGELVRLILVKMAKE LLF G+++PELL G+F T D+S IE +K+GI+ A+E+L RLG Sbjct: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Query: 361 LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKH 420 ++P+ DCV+ IC IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK H Sbjct: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 Query: 421 PHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLS 480 P +++R HKT+RRLVP DVRFL SE G+GKGAAMVTAVAYRLA+QHR ++TL H +LS Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 Query: 481 HDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRV 540 L+EVK+R++ EME GL KET++ A VKMLP++V + PDGTE GDFLALDLGGTNFRV Sbjct: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 Query: 541 LLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGF 600 LLV++R+GK VEMHNKIY+IP E+M GTGDELFDHIV CI+DFL+YMG+KG +PLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVG 660 TFSFPC Q +LD IL+ WTKGFKA+ CEG DV +LL++A+ RREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDD 720 TMMTC +E+P CE+GLIVGTG+NACYMEEM+NVE+VEG +G+MC+NMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 Query: 721 FRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRG 780 RT+FD VDE SLN GKQRFEKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRG Sbjct: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 Query: 781 IFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAA 840 IFETKFLSQIESD LALLQVRAILQ LGL STCDDSI+VK VC VV++RAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 Query: 841 VVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKG 900 VV++IRENRGLD L VTVGVDGTLYKLHPHF+++MH+TVK+L+PKC VSFL SEDGSGKG Sbjct: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 Query: 901 AALITAVACRIR 912 AALITAV R+R Sbjct: 901 AALITAVGVRLR 912 Score = 535 bits (1379), Expect = e-152, Method: Composition-based stats. Identities = 243/449 (54%), Positives = 337/449 (75%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 DQ + K L ++LS + L+++ R K EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 Query: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584 KGDF+ALDLGG++FR+L V+V + K V M ++IY P+ ++HG+G +LFDH+ C+ D Sbjct: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGD 136 Query: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644 F+E +K LP+GFTFSFPC+Q+ +DE++L+ WTK FKASG EG DVV LL +AI +R Sbjct: 137 FMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 Query: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 704 ++D ++VAVVNDTVGTMMTCG++D CEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 Query: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMY+GE+VR IL+ K Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316 Query: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 824 GLLF GRI+ L TRG F T +S IE D + + IL LG+E + D + V+ +CT Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICT 376 Query: 825 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 884 +V+ R+A L A + A+++R+R+N+G L+ TVGVDG+LYK+HP +++ H+T++ L P Sbjct: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVP 436 Query: 885 KCDVSFLQSEDGSGKGAALITAVACRIRE 913 DV FL SE G+GKGAA++TAVA R+ E Sbjct: 437 DSDVRFLLSESGTGKGAAMVTAVAYRLAE 465 >3W0L-A nrPDB Length = 458 Score = 651 bits (1680), Expect = 0.0, Method: Composition-based stats. Identities = 258/451 (57%), Positives = 331/451 (73%), Gaps = 5/451 (1%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 DQ+ + L L + L + RM+ EMERGL ET+ A VKMLPTYV +TPDG+E Sbjct: 5 DQNEVD-QILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSE 63 Query: 525 KGDFLALDLGGTNFRVLLVRVRN---GKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQC 581 GDFLALDLGGTNFRV+LV+V G+W VE +K+Y+IP + M GT + LFD+I +C Sbjct: 64 VGDFLALDLGGTNFRVMLVKVGEDLEGQWK-VETKHKMYSIPVDAMTGTAEMLFDYIAEC 122 Query: 582 IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAI 641 I+D+L+ MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI Sbjct: 123 ISDYLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 182 Query: 642 HRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEG 701 RR +F++DVVA+VNDTV TM++C +ED HCEVGLIVGTG NACYMEEM NVELVEGEEG Sbjct: 183 KRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEG 242 Query: 702 RMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDF 761 RMCVN EWGAFGD G L+DFR E+D VDE SLNPG+Q +EKMI G Y+GE+VR +LI Sbjct: 243 RMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKM 302 Query: 762 TKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKE 821 LLF G SE+LKTRG FET+F+SQIE+D Q IL+ LG+++T D V+ Sbjct: 303 VNENLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRL 362 Query: 822 VCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKD 881 C V+ RAA +C AG+A +++R+R++R + L++TVGVDG++YKLHP F H TV Sbjct: 363 ACESVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLK 422 Query: 882 LAPKCDVSFLQSEDGSGKGAALITAVACRIR 912 L C+++F+QSE+GSG+GAALI+AVA ++ Sbjct: 423 LTSGCEITFIQSEEGSGRGAALISAVAYKMA 453 Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats. Identities = 247/447 (55%), Positives = 336/447 (75%), Gaps = 2/447 (0%) Query: 20 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79 +VDQ L L +E L + R + EME+GL T+ A+VKMLPT+VRSTPDG+E G+ Sbjct: 7 NEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGD 66 Query: 80 FLALDLGGTNFRVLWVKVTD--NGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 137 FLALDLGGTNFRV+ VKV + G KVE ++++Y+IP D M G+ LFD+IAEC++++ Sbjct: 67 FLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDY 126 Query: 138 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197 +D+ +K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRG Sbjct: 127 LDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 186 Query: 198 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 257 DF++D+VA+VNDTV TM++C Y+DH+CE+GLIVGTG NACYMEEM ++++VEG+EGRMC+ Sbjct: 187 DFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCV 246 Query: 258 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 317 N EWGAFGD G L D R E+D+ +D SLNPG+QL+EKMI G YMGELVRL+L+KM E Sbjct: 247 NTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNEN 306 Query: 318 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 377 LLFGG+ S +L G FET+ +S IE + ++ +L LG+ T DC A C+ Sbjct: 307 LLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACES 366 Query: 378 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 437 VSTR+A +C+A LA +L R+++++ EE LR T+GVDGSVYK HP F + H TV +L G Sbjct: 367 VSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTSG 426 Query: 438 CDVRFLRSEDGSGKGAAMVTAVAYRLA 464 C++ F++SE+GSG+GAA+++AVAY++A Sbjct: 427 CEITFIQSEEGSGRGAALISAVAYKMA 453 >3HM8-A nrPDB Length = 445 Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats. Identities = 291/447 (65%), Positives = 365/447 (81%), Gaps = 7/447 (1%) Query: 467 HRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKG 526 R ++TL +L+HDQL V+ +M+ M +GL E ++ ++MLPT+V ATPDG+E+G Sbjct: 3 RRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERG 59 Query: 527 DFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL 586 DFLALDLGGTNFRVLLVRV G V++ ++IY+IP+ V G+G +LFDHIV CI DF Sbjct: 60 DFLALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 115 Query: 587 EYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREE 646 + G+ G SLPLGFTFSFPC+Q LD+ ILL WTKGFKAS CEG+DVV+LL+EAI RR+ Sbjct: 116 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 175 Query: 647 FDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVN 706 +L+VVA+VNDTVGTMM+CG+EDP CE+GLIVGTG+NACYMEE+RNV V G+ GRMC+N Sbjct: 176 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 235 Query: 707 MEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGL 766 MEWGAFGD+G L T FD +VD+ S+NPGKQRFEKMISGMYLGEIVR+IL+ T G+ Sbjct: 236 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 295 Query: 767 LFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVV 826 LFRG+ +RL+TR IF+TKFLS+IESD LAL QVRAIL+ LGL T DD+++V EVC V Sbjct: 296 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 355 Query: 827 ARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKC 886 ++RAAQLCGAG+AAVV++IRENRGL+ L V+VGVDGTLYKLHP F+ ++ TV++LAP+C Sbjct: 356 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 415 Query: 887 DVSFLQSEDGSGKGAALITAVACRIRE 913 V+FLQSEDGSGKGAAL+TAVACR+ + Sbjct: 416 VVTFLQSEDGSGKGAALVTAVACRLAQ 442 Score = 597 bits (1539), Expect = e-171, Method: Composition-based stats. Identities = 243/447 (54%), Positives = 323/447 (72%), Gaps = 7/447 (1%) Query: 22 VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81 +++ L RL+ + L + + RK M KGL ++++MLPTFVR+TPDG+E G+FL Sbjct: 6 LEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGDFL 62 Query: 82 ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141 ALDLGGTNFRVL V+VT V++ ++IY+IPE + +GSG QLFDHI +C+ +F K Sbjct: 63 ALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 118 Query: 142 QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDI 201 + + LPLGFTFSFPC Q LD+ L++WTKGFK+S EG+DVV+L+R+AI RR ++ Sbjct: 119 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 178 Query: 202 DIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEW 261 ++VA+VNDTVGTMM+CGY+D CEIGLIVGTG+NACYMEE+R++ V GD GRMCINMEW Sbjct: 179 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEW 238 Query: 262 GAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFG 321 GAFGDDGSL + T FD +D S+NPGKQ FEKMISGMY+GE+VR IL+ + +LF Sbjct: 239 GAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFR 298 Query: 322 GKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTR 381 G+ L F+TK +S+IE + +R+ R +L LGL T +D + +CQ VS R Sbjct: 299 GQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQR 358 Query: 382 SASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVR 441 +A LC A +AAV+++I+EN+G E L ++GVDG++YK HP F+ + TVR L P C V Sbjct: 359 AAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVT 418 Query: 442 FLRSEDGSGKGAAMVTAVAYRLADQHR 468 FL+SEDGSGKGAA+VTAVA RLA R Sbjct: 419 FLQSEDGSGKGAALVTAVACRLAQLTR 445 >4DCH-A nrPDB Length = 473 Score = 637 bits (1642), Expect = 0.0, Method: Composition-based stats. Identities = 251/451 (55%), Positives = 336/451 (74%), Gaps = 2/451 (0%) Query: 464 ADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGT 523 A + ++ L QL + L +V RRM+ EM+RGL ETH A VKMLPTYV +TP+G+ Sbjct: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 Query: 524 EKGDFLALDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQC 581 E GDFL+LDLGGTNFRV+LV+V G+ G V+ +++Y+IP++ M GT + LFD+I +C Sbjct: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 Query: 582 IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAI 641 I+DFL+ MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 Query: 642 HRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEG 701 RR +F++DVVA+VNDTV TM++C +ED CEVG+IVGTG NACYMEEM+NVELVEG+EG Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 Query: 702 RMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDF 761 RMCVN EWGAFGD+G LD+F E+D VDE S NPG+Q +EK+I G Y+GE+VR +L+ Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 Query: 762 TKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKE 821 LLF G SE+L+TRG FET+F+SQ+ESD Q+ IL LGL + D IV+ Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 Query: 822 VCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKD 881 C V+ RAA +C AG+A V++R+RE+R D +++TVGVDG++YKLHP F + H +V+ Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 Query: 882 LAPKCDVSFLQSEDGSGKGAALITAVACRIR 912 L P C+++F++SE+GSG+GAAL++AVAC+ Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACKKA 460 Score = 619 bits (1597), Expect = e-177, Method: Composition-based stats. Identities = 242/454 (53%), Positives = 341/454 (75%), Gaps = 2/454 (0%) Query: 20 QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGE 79 +KV+Q L +L +E L ++ +R +KEM++GL TH A+VKMLPT+VRSTP+G+E G+ Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 80 FLALDLGGTNFRVLWVKVTD--NGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANF 137 FL+LDLGGTNFRV+ VKV + G V+ ++Q+Y+IPED M G+ LFD+I+EC+++F Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 Query: 138 MDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRG 197 +DK Q+K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRG Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 Query: 198 DFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCI 257 DF++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+ Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 Query: 258 NMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEE 317 N EWGAFGD G L++ E+D+ +D S NPG+QL+EK+I G YMGELVRL+L+++ E Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 Query: 318 LLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQI 377 LLF G+ S +L G FET+ +S +E + ++ +L LGL P+ DC R C+ Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 Query: 378 VSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPG 437 VSTR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 Query: 438 CDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQ 471 C++ F+ SE+GSG+GAA+V+AVA + A + Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKACMLGQLE 467 >3O1W-A nrPDB Length = 485 Score = 578 bits (1490), Expect = e-165, Method: Composition-based stats. Identities = 156/476 (32%), Positives = 261/476 (54%), Gaps = 35/476 (7%) Query: 463 LADQHRARQKTLEH----LQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCA 518 +AD + + +S +++ + + E+++GLSK+ + M+P +V Sbjct: 16 MADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKK---GGNIPMIPGWVVE 72 Query: 519 TPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHI 578 P G E GDFLALDLGGTN RV+LV++ + Y +P + GT ++L+ I Sbjct: 73 YPTGKETGDFLALDLGGTNLRVVLVKLGGNHD--FDTTQNKYRLPDHLRTGTSEQLWSFI 130 Query: 579 VQCIADFLEYMGMKGVS--LPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTL 636 +C+ +F++ GVS LPLGFTFS+P Q ++ +L +WTKGF G EG DVV + Sbjct: 131 AKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPM 190 Query: 637 LKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELV 696 L+E I + ++VVA++NDT GT++ + DP ++G+I+GTG N Y + + +E + Sbjct: 191 LQEQIEKLN-IPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKL 249 Query: 697 EG-------EEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMY 749 EG + M +N E+G+F DN L RT++DV +DE S PG+Q FEKM SG Y Sbjct: 250 EGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYY 308 Query: 750 LGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAIL--QHL 807 LGEI+R +L+D G +F+ + +LK + +T + S+IE D L+ L +L Sbjct: 309 LGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNL 368 Query: 808 GLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKL 867 +E+T + +++++ +V RAA+L G++A+ D+ + DG+++ Sbjct: 369 NIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDKRGYKT------AHIAADGSVFNR 422 Query: 868 HPHFAKVMHETVKDLAPKC-------DVSFLQSEDGSGKGAALITAVACRIREAGQ 916 +P + + + +KD+ + + +EDGSG GAA+I + + AG+ Sbjct: 423 YPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQKRLAAGK 478 Score = 540 bits (1392), Expect = e-154, Method: Composition-based stats. Identities = 144/462 (31%), Positives = 246/462 (53%), Gaps = 31/462 (6%) Query: 19 VQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHG 78 ++++ +S E + I K F E++KGL + + M+P +V P G E G Sbjct: 24 MEQIHGLETLFTVSSEKMRSIVKHFISELDKGL---SKKGGNIPMIPGWVVEYPTGKETG 80 Query: 79 EFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFM 138 +FLALDLGGTN RV+ VK+ N + Y +P+ + G+ QL+ IA+CL F+ Sbjct: 81 DFLALDLGGTNLRVVLVKLGGN--HDFDTTQNKYRLPDHLRTGTSEQLWSFIAKCLKEFV 138 Query: 139 DKLQIK--DKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 196 D+ + LPLGFTFS+P Q K++ L WTKGF GVEG DVV ++++ I++ Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198 Query: 197 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG------ 250 + I++VA++NDT GT++ Y D ++G+I+GTG N Y + + I+ +EG Sbjct: 199 -NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDI 257 Query: 251 -DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLI 309 + M IN E+G+F D+ L RT++D ID S PG+Q FEKM SG Y+GE++RL+ Sbjct: 258 GPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLV 316 Query: 310 LVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVL-MRLGLDPTQED 367 L+ + +F + +L +T S IE + + + ++ L ++ T + Sbjct: 317 LLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVE 376 Query: 368 CVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRL 427 ++ ++V TR+A L ++A+ + I DGSV+ ++P + ++ Sbjct: 377 RKLIRKLAELVGTRAARLTVCGVSAICDKRGYKTAH------IAADGSVFNRYPGYKEKA 430 Query: 428 HKTVRRL-------VPGCDVRFLRSEDGSGKGAAMVTAVAYR 462 + ++ + + ++ + +EDGSG GAA++ + + Sbjct: 431 AQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQK 472 >1BDG-A nrPDB Length = 451 Score = 574 bits (1479), Expect = e-164, Method: Composition-based stats. Identities = 211/452 (46%), Positives = 283/452 (62%), Gaps = 15/452 (3%) Query: 465 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 524 + L+ LS E+ RM M GL K T+ + +KM P+YV TP+GTE Sbjct: 7 QLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTE 66 Query: 525 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 584 G+FLALDLGGTN+RVL V + GK + + Y IP E M G+G ELF +I + +AD Sbjct: 67 TGNFLALDLGGTNYRVLSVTL-EGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 585 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 644 FLE GMK LGFTFSFPC Q L + L++WTKGF A G EG +V LL+ + +R Sbjct: 126 FLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG-EEGRM 703 E ++ VAVVNDTVGT+ +C EDP C VGLIVGTG+N Y+E+ VEL++G +E + Sbjct: 186 E-LNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEV 244 Query: 704 CVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTK 763 +N EWGAFG+ G LD +RT+FD ++D SL+PGKQ +EKM+SGMYLGE+VR+I++ + Sbjct: 245 VINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVE 304 Query: 764 RGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAIL----QHLGLESTCDDSIIV 819 + +LFRG + ERLK R T++L+ +E D LL + H+ + D+ IV Sbjct: 305 QKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNR-IV 363 Query: 820 KEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETV 879 + C +V +RAA L GAG+A ++ RI + +VTVGVDG+LYK HP F + M + V Sbjct: 364 RYACEMVVKRAAYLAGAGIACILRRINRS------EVTVGVDGSLYKFHPKFCERMTDMV 417 Query: 880 KDLAPKCDVSFLQ-SEDGSGKGAALITAVACR 910 L PK L+ SEDGSGKGAA I A R Sbjct: 418 DKLKPKNTRFCLRLSEDGSGKGAAAIAASCTR 449 Score = 546 bits (1407), Expect = e-155, Method: Composition-based stats. Identities = 193/456 (42%), Positives = 280/456 (61%), Gaps = 16/456 (3%) Query: 14 LNHDQV-QKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTP 72 + Q+ +KV + L LS EI R + M GL +T+ +++KM P++V TP Sbjct: 3 FSDQQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTP 62 Query: 73 DGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAE 132 +GTE G FLALDLGGTN+RVL V + G + ++ + Y IP + M GSGT+LF +IAE Sbjct: 63 NGTETGNFLALDLGGTNYRVLSVTLEGKG-KSPRIQERTYCIPAEKMSGSGTELFKYIAE 121 Query: 133 CLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKA 192 LA+F++ +KDKK LGFTFSFPC Q L + LV WTKGF + GVEG +V L++ Sbjct: 122 TLADFLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTE 181 Query: 193 IQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG-D 251 + +R + ++ VAVVNDTVGT+ +C +D C +GLIVGTG+N Y+E+ +++++G Sbjct: 182 LDKR-ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVK 240 Query: 252 EGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILV 311 E + IN EWGAFG+ G L+ RT+FD+ +D+ SL+PGKQL+EKM+SGMY+GELVR I+V Sbjct: 241 EPEVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIV 300 Query: 312 KMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQE---DC 368 + ++++LF G L L T+ ++D+E + + ++ L D Sbjct: 301 YLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDN 360 Query: 369 VATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLH 428 C++V R+A L A +A +L+RI + T+GVDGS+YK HP F +R+ Sbjct: 361 RIVRYACEMVVKRAAYLAGAGIACILRRINRS------EVTVGVDGSLYKFHPKFCERMT 414 Query: 429 KTVRRLVPGCDVRFL--RSEDGSGKGAAMVTAVAYR 462 V +L P + RF SEDGSGKGAA + A R Sbjct: 415 DMVDKLKPK-NTRFCLRLSEDGSGKGAAAIAASCTR 449 >1IG8-A nrPDB Length = 486 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 156/478 (32%), Positives = 258/478 (53%), Gaps = 38/478 (7%) Query: 463 LADQHRARQKTLEHLQ----LSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCA 518 +AD + + +E+ + + + L V + E+E+GLSK+ + M+P +V Sbjct: 16 MADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMD 72 Query: 519 TPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGT--GDELFD 576 P G E GDFLA+DLGGTN RV+LV++ + Y +P + M T DEL++ Sbjct: 73 FPTGKESGDFLAIDLGGTNLRVVLVKLGGD--RTFDTTQSKYRLP-DAMRTTQNPDELWE 129 Query: 577 HIVQCIADFLEYMGMKGVS--LPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVV 634 I + F++ +G+S +PLGFTFSFP QN ++E IL +WTKGF E DVV Sbjct: 130 FIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVV 189 Query: 635 TLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVE 694 +L++ I +R ++VVA++NDT GT++ + DP ++G+I GTG N Y + ++E Sbjct: 190 PMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIE 248 Query: 695 LVEGE-------EGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISG 747 ++G+ M +N E+G+F DN + RT++D+ +DE S PG+Q FEKM SG Sbjct: 249 KLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSG 307 Query: 748 MYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAIL--Q 805 YLGEI+R L+D K+G +F+ + + + +T + ++IE D L+ L Sbjct: 308 YYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN 367 Query: 806 HLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLY 865 G+ +T + +++ + ++ RAA+L G+AA+ + G + DG++Y Sbjct: 368 EFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVY 421 Query: 866 KLHPHFAKVMHETVKDLAP-------KCDVSFLQSEDGSGKGAALITAVACRIREAGQ 916 +P F + +KD+ + + +EDGSG GAA+I A+A + G+ Sbjct: 422 NRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGK 479 Score = 516 bits (1330), Expect = e-146, Method: Composition-based stats. Identities = 141/449 (31%), Positives = 236/449 (52%), Gaps = 34/449 (7%) Query: 19 VQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHG 78 +Q+++ + + ETL ++K F E+EKGL + + M+P +V P G E G Sbjct: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESG 80 Query: 79 EFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSG--TQLFDHIAECLAN 136 +FLA+DLGGTN RV+ VK+ + + Y +P D MR + +L++ IA+ L Sbjct: 81 DFLAIDLGGTNLRVVLVKLGG--DRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSLKA 137 Query: 137 FMDKL--QIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQ 194 F+D+ Q + +PLGFTFSFP Q K++E L WTKGF +E DVV +++K I Sbjct: 138 FIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 Query: 195 RRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---- 250 +R + I++VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 198 KR-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSD 256 Query: 251 ---DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVR 307 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG Y+GE++R Sbjct: 257 DIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILR 315 Query: 308 LILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLMR-LGLDPTQ 365 L L+ M K+ +F + + +T + IE + + + ++ G++ T Sbjct: 316 LALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTV 375 Query: 366 EDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAK 425 ++ R+ +++ R+A L +AA+ Q+ G I DGSVY ++P F + Sbjct: 376 QERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNRYPGFKE 429 Query: 426 RLHKTVRRLVPGC-------DVRFLRSED 447 + ++ + ++ + +ED Sbjct: 430 KAANALKDIYGWTQTSLDDYPIKIVPAED 458 >3B8A-X nrPDB Length = 485 Score = 542 bits (1397), Expect = e-154, Method: Composition-based stats. Identities = 156/477 (32%), Positives = 266/477 (55%), Gaps = 37/477 (7%) Query: 463 LADQHRARQKTLEH----LQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCA 518 +AD + + + + L +V + E+ +GL+K+ + M+P +V Sbjct: 16 MADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKK---GGNIPMIPGWVME 72 Query: 519 TPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGT-GDELFDH 577 P G E G++LA+DLGGTN RV+LV++ + Y +P ++ +EL+ Sbjct: 73 FPTGKESGNYLAIDLGGTNLRVVLVKLSGNH--TFDTTQSKYKLPHDMRTTKHQEELWSF 130 Query: 578 IVQCIADFL---EYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVV 634 I + DF+ E + K +LPLGFTFS+P QN ++E IL +WTKGF EG DVV Sbjct: 131 IADSLKDFMVEQELLNTKD-TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVV 189 Query: 635 TLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVE 694 LL+ I +RE +++VA++NDTVGT++ + DP ++G+I GTG N + + + ++E Sbjct: 190 PLLQNEISKRE-LPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIE 248 Query: 695 LVEGE-------EGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISG 747 +EG+ M +N E+G+F DN L RT++DVAVDE S PG+Q FEKM SG Sbjct: 249 KLEGKLADDIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSG 307 Query: 748 MYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAIL--Q 805 YLGE++R +L++ ++GL+ + + +LK I +T + ++IE D L+ + + Sbjct: 308 YYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQK 367 Query: 806 HLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLY 865 G+++T + +++ +C ++ RAA+L G+AA+ + G + DG++Y Sbjct: 368 DFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTG------HIAADGSVY 421 Query: 866 KLHPHFAKVMHETVKDL------APKCDVSFLQSEDGSGKGAALITAVACRIREAGQ 916 +P F + + ++D+ A K ++ + +EDGSG GAA+I A++ + G+ Sbjct: 422 NKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKRIAEGK 478 Score = 512 bits (1319), Expect = e-145, Method: Composition-based stats. Identities = 155/470 (32%), Positives = 251/470 (53%), Gaps = 31/470 (6%) Query: 19 VQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHG 78 + ++ Q + ETL ++ K F E+ KGL T + M+P +V P G E G Sbjct: 24 MDEIHQLEDMFTVDSETLRKVVKHFIDELNKGL---TKKGGNIPMIPGWVMEFPTGKESG 80 Query: 79 EFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGS-GTQLFDHIAECLANF 137 +LA+DLGGTN RV+ VK++ N + Y +P D+ +L+ IA+ L +F Sbjct: 81 NYLAIDLGGTNLRVVLVKLSGN--HTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDF 138 Query: 138 MDKLQIKDKK--LPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 195 M + ++ + K LPLGFTFS+P Q K++E L WTKGF VEG DVV L++ I + Sbjct: 139 MVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISK 198 Query: 196 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGD---- 251 R + I+IVA++NDTVGT++ Y D ++G+I GTG N + + + I+ +EG Sbjct: 199 R-ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADD 257 Query: 252 ---EGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRL 308 M IN E+G+F D+ L RT++D +D S PG+Q FEKM SG Y+GEL+RL Sbjct: 258 IPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRL 316 Query: 309 ILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEK-DGIRKAREVLM-RLGLDPTQE 366 +L+++ ++ L+ + +L +T + IE + + + ++ G+ T Sbjct: 317 VLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLP 376 Query: 367 DCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKR 426 + R+C+++ TR+A L +AA+ Q+ G I DGSVY K+P F + Sbjct: 377 ERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGH------IAADGSVYNKYPGFKEA 430 Query: 427 LHKTVRRLVPGC------DVRFLRSEDGSGKGAAMVTAVAYRLADQHRAR 470 K +R + + + +EDGSG GAA++ A++ + + ++ Sbjct: 431 AAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKRIAEGKSL 480 >5ZQT-A nrPDB Length = 473 Score = 536 bits (1381), Expect = e-152, Method: Composition-based stats. Identities = 168/457 (36%), Positives = 237/457 (51%), Gaps = 24/457 (5%) Query: 469 ARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDF 528 ++ + L + M EMERGL + H AP+KML +YV P G E G F Sbjct: 15 VIEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLF 72 Query: 529 LALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL-- 586 ALDLGGTNFRV+ V++ + V + AIP +M GT ELFD I + F+ Sbjct: 73 YALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKT 132 Query: 587 ---EYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHR 643 ++ +G LGFTFSFP Q S+ L+KWTKGF +G GEDVV L A+ Sbjct: 133 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME- 191 Query: 644 REEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EE 700 R+ D+ V A+VNDTVGT+ + D +I+GTG+NA Y+E + G Sbjct: 192 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 251 Query: 701 GRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILID 760 G M +NMEWG F R+++D A+D SLNPG+Q +EKMISGMYLGEIVR IL+ Sbjct: 252 GNMVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 308 Query: 761 FTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGL-ESTCDDSI 817 LF + +L+ R I T +S + D L+ + LG+ +++ + Sbjct: 309 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 368 Query: 818 IVKEVCTVVARRAAQLCGAGMAAVVDRIRENR----GLDALKVTVGVDGTLYKLHPHFAK 873 I VC +VA R A+L AG+ ++ ++ +R G + + +DG LY+ + F Sbjct: 369 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 428 Query: 874 VMHETVKDL---APKCDVSFLQSEDGSGKGAALITAV 907 + T+ DL V + DGSG GAAL+ A Sbjct: 429 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAAS 465 Score = 513 bits (1320), Expect = e-145, Method: Composition-based stats. Identities = 171/464 (36%), Positives = 257/464 (55%), Gaps = 26/464 (5%) Query: 22 VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81 +++ L I+ +EME+GL A H A +KML ++V + P G EHG F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLFY 73 Query: 82 ALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKL 141 ALDLGGTNFRV+ V++ + V + + AIP +M G+ +LFD IA L +F+ K Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KT 132 Query: 142 QIKDKKLP------LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 195 + +D LP LGFTFSFP HQT + L+ WTKGF +G G DVVA + +A++R Sbjct: 133 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 192 Query: 196 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DE 252 +G D+ + A+VNDTVGT+ Y D++ +I+GTG+NA Y+E I G Sbjct: 193 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 251 Query: 253 GRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVK 312 G M INMEWG F + R+++D +D SLNPG+Q++EKMISGMY+GE+VR IL+K Sbjct: 252 GNMVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 308 Query: 313 MAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGL-DPTQEDCV 369 +A + LFG + +L T D+S + + K ++ LG+ D + E Sbjct: 309 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARY 368 Query: 370 ATHRICQIVSTRSASLCAATLAAVLQRIKENK----GEERLRSTIGVDGSVYKKHPHFAK 425 T +C +V+ R A L AA + +L+++ ++ G ++ R+ I +DG +Y+ + F Sbjct: 369 ITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRT 428 Query: 426 RLHKTVRRLV---PGCDVRFLRSEDGSGKGAAMVTAVAYRLADQ 466 L T+ L+ V + DGSG GAA++ A + A Sbjct: 429 CLEATLADLLGEEAASSVVVKLANDGSGIGAALLAASHSQYASV 472 >4QS9-A nrPDB Length = 474 Score = 526 bits (1356), Expect = e-149, Method: Composition-based stats. Identities = 157/444 (35%), Positives = 237/444 (53%), Gaps = 22/444 (4%) Query: 480 SHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFR 539 +L +V M VEM GL+ + + +KML +YV P G EKG F ALDLGGTNFR Sbjct: 29 PISKLRQVADAMTVEMHAGLASD--GGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFR 86 Query: 540 VLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFL-----EYMGMKGV 594 V+ V + + V+ + +IP +M G DELF+ I + +A F+ ++ +G Sbjct: 87 VMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGR 146 Query: 595 SLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAV 654 LGFTF+FP +Q SL L+KWTKGF G+DVV L +A+ R D+ + A+ Sbjct: 147 QRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAAL 205 Query: 655 VNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEG---EEGRMCVNMEWGA 711 VNDTVGT+ + +P +I+GTG+NA Y+E + G + G M +NMEWG Sbjct: 206 VNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGN 265 Query: 712 FGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGR 771 F + TEFD +D SLNPG+Q EK+ISGMYLGEI+R +L+ + F Sbjct: 266 FRSSH---LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDT 322 Query: 772 ISERLKTRGIFETKFLSQIESDCLALLQV--RAILQHLGLEST-CDDSIIVKEVCTVVAR 828 + +L+ I T +S + +D L++ I L + +T +V +C ++A Sbjct: 323 VPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIAT 382 Query: 829 RAAQLCGAGMAAVVDRIRENRGLD--ALKVTVGVDGTLYKLHPHFAKVMHETVKDL---A 883 R A+L AG+ ++ ++ + D K + +DG L++ + F++ M ++K+L Sbjct: 383 RGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDE 442 Query: 884 PKCDVSFLQSEDGSGKGAALITAV 907 V S DGSG GAAL+ A Sbjct: 443 ASGSVEVTHSNDGSGIGAALLAAS 466 Score = 489 bits (1259), Expect = e-138, Method: Composition-based stats. Identities = 158/447 (35%), Positives = 238/447 (53%), Gaps = 28/447 (6%) Query: 32 SDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFR 91 L +++ EM GL + + +KML ++V + P G E G F ALDLGGTNFR Sbjct: 29 PISKLRQVADAMTVEMHAGLASDG--GSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFR 86 Query: 92 VLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLP-- 149 V+ V + + V+ E + +IP +M G +LF+ IAE LA F+ + +D LP Sbjct: 87 VMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-ATECEDFHLPEG 145 Query: 150 ----LGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVA 205 LGFTF+FP QT L L+ WTKGF G+DVV + KA++R G D+ I A Sbjct: 146 RQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAA 204 Query: 206 VVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---DEGRMCINMEWG 262 +VNDTVGT+ Y + + +I+GTG+NA Y+E I G G M INMEWG Sbjct: 205 LVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWG 264 Query: 263 AFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGG 322 F S + TEFD +D SLNPG+Q+ EK+ISGMY+GE++R +L+KMA++ FG Sbjct: 265 NF---RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGD 321 Query: 323 KLSPELLNTGRFETKDISDIEGEKD-----GIRKAREVLMRLGLDPTQEDCVATHRICQI 377 + +L T +S + + K +++L +C I Sbjct: 322 TVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKM--RKVVISLCNI 379 Query: 378 VSTRSASLCAATLAAVLQRIKEN--KGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV 435 ++TR A L AA + +L+++ + K EE +S I +DG +++ + F++ + +++ L+ Sbjct: 380 IATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELL 439 Query: 436 PG---CDVRFLRSEDGSGKGAAMVTAV 459 V S DGSG GAA++ A Sbjct: 440 GDEASGSVEVTHSNDGSGIGAALLAAS 466 >2YHX-A nrPDB Length = 457 Score = 196 bits (498), Expect = 4e-50, Method: Composition-based stats. Identities = 69/420 (16%), Positives = 140/420 (33%), Gaps = 40/420 (9%) Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIY------AI 114 + M+P +V G + G FLA+ +GG + V+ + + + + AI Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAI 103 Query: 115 PEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKG 174 P D+ + A + +PLGFTF + + + + Sbjct: 104 PSDLWG-------NXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 175 FKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGS 234 F + + +++ + A GD VA + D+ G + Y D ++G+I G+G Sbjct: 157 FSLAXL--XKLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 235 NACYMEEMRHI-----DMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPG 289 NA Y + I G G M I + +F + + + ++ S Sbjct: 214 NAAYWCDSTXIGDAADGGXXGGAGXMXICCDQSSFR-KAFPSLPQIXYLXTLNXXSPXAX 272 Query: 290 KQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKD-G 348 K F K G+ +R +L+ + T + I+ Sbjct: 273 K-TFXKNSXAKNXGQSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFD 330 Query: 349 IRKAREVLM-RLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLR 407 +R ++ G+ R +++ + L + A+ Q+ + G Sbjct: 331 LRXXXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSGH---- 386 Query: 408 STIGVDGSVYKKHPHFAKRLHKTVRRLVPG-------CDVRFLRSEDGSGKGAAMVTAVA 460 I GS + + F+ + + + DG G + ++ ++A Sbjct: 387 --IAAXGSX-RSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIA 443 Score = 126 bits (316), Expect = 5e-29, Method: Composition-based stats. Identities = 69/417 (16%), Positives = 148/417 (35%), Gaps = 34/417 (8%) Query: 509 VKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMH 568 + M+P +V G + G FLA+ +GG + V+L+ + + + + A M Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAA----AMS 99 Query: 569 GT--GDELFDHIVQC-IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKA 625 T +L+ + A S+PLGFTF + + + + F Sbjct: 100 TTAIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSL 159 Query: 626 SGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNAC 685 + +++ + A + VA + D+ G + + D ++G+I G+G NA Sbjct: 160 AXLX--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAA 216 Query: 686 YMEEMRNV-----ELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQR 740 Y + + G G M + + +F + + ++ S K Sbjct: 217 YWCDSTXIGDAADGGXXGGAGXMXICCDQSSFR-KAFPSLPQIXYLXTLNXXSPXAXK-T 274 Query: 741 FEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV 800 F K G+ +R++L+ F G + + T + ++I+ L+ Sbjct: 275 FXKNSXAKNXGQSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRX 333 Query: 801 RAIL--QHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTV 858 L G+ +V+ ++A A +L + A+ + + G + Sbjct: 334 XXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HI 387 Query: 859 GVDGTLYKLHPHFAKVMHETVKDLA-------PKCDVSFLQSEDGSGKGAALITAVA 908 G+ + + F+ ++ + + DG G + +I ++A Sbjct: 388 AAXGSX-RSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIA 443 >1HKG-A nrPDB Length = 457 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 69/420 (16%), Positives = 142/420 (33%), Gaps = 40/420 (9%) Query: 61 VKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIY------AI 114 + M+P +V G++ G FLA+ +GG + V+ + + + + AI Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 115 PEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKG 174 P D+ + A + +PLGFTF + + + + Sbjct: 104 PSDLWG-------NXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXA 156 Query: 175 FKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGS 234 F + + +++ + A GD VA + D+ G + Y D ++G+I G+G Sbjct: 157 FSLAXL--XKLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGV 213 Query: 235 NACYMEEMRHI-----DMVEGDEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPG 289 NA Y + I G G M + +F + + + ++ S Sbjct: 214 NAAYWCDSTXIADAADAGXXGGAGXMXVCCXQDSFR-KAFPSLPQIXYXXTLNXXSPXAX 272 Query: 290 KQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKD-G 348 K FEK G+ +R +L+ K + + + + I+ Sbjct: 273 K-TFEKNSXAKNXGQSLRDVLMX-YKXXGQXHXXXAXDFXAANVENSSYPAKIQKLPHFD 330 Query: 349 IRKAREVLM-RLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLR 407 +R ++ G+ R +++ + L + A+ Q+ + G Sbjct: 331 LRXXXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSGH---- 386 Query: 408 STIGVDGSVYKKHPHFAKRLHKTVRRLVPG-------CDVRFLRSEDGSGKGAAMVTAVA 460 I GS + + F+ + + + DG G ++ ++A Sbjct: 387 --IAAXGSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 Score = 120 bits (301), Expect = 3e-27, Method: Composition-based stats. Identities = 69/417 (16%), Positives = 148/417 (35%), Gaps = 34/417 (8%) Query: 509 VKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMH 568 + M+P +V G++ G FLA+ +GG + V+L+ + + + + A M Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAA----SMX 99 Query: 569 GT--GDELFDHIVQC-IADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKA 625 T +L+ + A S+PLGFTF + + + + F Sbjct: 100 TTAIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSL 159 Query: 626 SGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNAC 685 + +++ + A + VA + D+ G + + D ++G+I G+G NA Sbjct: 160 AXLX--KLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAA 216 Query: 686 YMEEMRNV-----ELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQR 740 Y + + G G M V +F + + ++ S K Sbjct: 217 YWCDSTXIADAADAGXXGGAGXMXVCCXQDSFR-KAFPSLPQIXYXXTLNXXSPXAXK-T 274 Query: 741 FEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQV 800 FEK G+ +R++L+ + G + + + + ++I+ L+ Sbjct: 275 FEKNSXAKNXGQSLRDVLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFDLRX 333 Query: 801 RAIL--QHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTV 858 L G+ +V+ ++A A +L + A+ + + G + Sbjct: 334 XXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HI 387 Query: 859 GVDGTLYKLHPHFAKVMHETVKDLA-------PKCDVSFLQSEDGSGKGAALITAVA 908 G+ + + F+ ++ + + DG G +I ++A Sbjct: 388 AAXGSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 >1R6M-A nrPDB Length = 239 Score = 33.8 bits (76), Expect = 0.32, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 51/143 (35%), Gaps = 20/143 (13%) Query: 356 LMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLA-----AVLQRIKENKGEERLRSTI 410 L +LG + DC TR+AS+ AT+A AVL++ KG + Sbjct: 105 LSKLGENTLYIDCDVIQADG---GTRTASITGATVALIDALAVLKKRGALKGNPLKQMVA 161 Query: 411 GVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSE-------DGSGKGAAMVTAVAYRL 463 V +Y+ P + D+ + ++ G+ +GA A + Sbjct: 162 AVSVGIYQGVPVLD---LDYLEDSAAETDLNVVMTDAGGFIEVQGTAEGAPFRPAELNAM 218 Query: 464 ADQHRARQKTLEHLQLSHDQLLE 486 + + + L +L L E Sbjct: 219 LELAQQGMQEL--FELQRAALAE 239 >3ZYM-A nrPDB Length = 310 Score = 33.1 bits (74), Expect = 0.55, Method: Composition-based stats. Identities = 21/159 (13%), Positives = 52/159 (32%), Gaps = 10/159 (6%) Query: 299 GMYMGELVRLILVKMAKEELLFGGKLSPELLNT----GRFETKDISDIEGEKDGIRKARE 354 G M +R + ++ + + G T + + I+ + Sbjct: 124 GYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMD 183 Query: 355 VLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDG 414 L+ ++ + + ++ + L AA ++ +++ ++ + G+D Sbjct: 184 ALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLD- 242 Query: 415 SVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSE-DGSGKG 452 + F R+ + L V R + GSG G Sbjct: 243 ----IYKKFLTRMTRISEFLKVAEQVGIDRGDISGSGSG 277 >3ZYK-A nrPDB Length = 296 Score = 31.9 bits (71), Expect = 1.4, Method: Composition-based stats. Identities = 22/174 (12%), Positives = 58/174 (33%), Gaps = 11/174 (6%) Query: 299 GMYMGELVRLILVKMAKEELLFGGKLSPELLNT----GRFETKDISDIEGEKDGIRKARE 354 G M +R + ++ + + G T + + I+ + Sbjct: 124 GYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMD 183 Query: 355 VLMRLGLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDG 414 L+ ++ + + ++ + L AA ++ +++ ++ + G+D Sbjct: 184 ALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLD- 242 Query: 415 SVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSE--DGSGKGAAMVTAVAYRLADQ 466 + F R+ + L V R + D S ++++ A+ LA Sbjct: 243 ----IYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASL 292 >2BWY-A nrPDB Length = 440 Score = 31.1 bits (69), Expect = 2.1, Method: Composition-based stats. Identities = 25/109 (22%), Positives = 44/109 (40%), Gaps = 21/109 (19%) Query: 229 IVGTGSNACYMEEMRH-IDMVEGDEGRMCINMEWGAFGDDGSLNDI---------RTEFD 278 IVG+G N C + + +M +GD + E+ + D + R +D Sbjct: 232 IVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYD 291 Query: 279 QEID--MGSLN---PGKQLFEKMISGMYMGELVRLILVKMAKEELLFGG 322 ++ SL PG + E GE+VR+++ + K +L G Sbjct: 292 IVLESLETSLRLYRPGTSILE------VTGEVVRIMVSGLVKLGILKGD 334 >5ZI1-A nrPDB Length = 609 Score = 30.7 bits (68), Expect = 3.2, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 21/42 (50%) Query: 399 ENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDV 440 +G +L++ GV G V++ + F + + V L+P + Sbjct: 194 YKEGLNKLKNASGVKGKVWENYNRFRREMTIMVLDLLPLFPI 235 >3BPV-A nrPDB Length = 138 Score = 30.4 bits (67), Expect = 4.3, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 33/83 (39%), Gaps = 3/83 (3%) Query: 751 GEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLE 810 G I R L + G + R + E + R I E + E L L L + Sbjct: 58 GTIAR-TLRRLEESGFIEREQDPEN-RRRYILEVTRRGE-EIIPLILKVEERWEDLLFRD 114 Query: 811 STCDDSIIVKEVCTVVARRAAQL 833 T D+ + +++C +A A ++ Sbjct: 115 FTEDERKLFRKMCRRLAEEAVRM 137 >5X0B-A nrPDB Length = 242 Score = 30.0 bits (66), Expect = 4.9, Method: Composition-based stats. Identities = 28/190 (14%), Positives = 62/190 (32%), Gaps = 32/190 (16%) Query: 394 LQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGC--DVRFLRSEDGSGK 451 LQ++ + + D VY +P F L++ V RL + +E+ + + Sbjct: 77 LQKLGAKRAPSVILDYFSDDVKVYTWYPAFKGDLNEVVERLKKEGLEVIEDPEAEEKAER 136 Query: 452 GAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVE-----MERGLSKETHAS 506 G V + ++ ++ +V M VE + GL ++ Sbjct: 137 GEIAFALVGEKSFAIPGGLEEQ--------KKVSKVLDEMSVEGKIELIYYGLKEDARED 188 Query: 507 -APVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQE 565 A ++ ++ P E ++ V+ G+ + + + Sbjct: 189 MAKGEIDYVFIRKAPTKEE----------------VMELVKRGEVYSPKTTRHVLPFNPD 232 Query: 566 VMHGTGDELF 575 + +ELF Sbjct: 233 KIDVKLEELF 242 >5SVC-B nrPDB Length = 727 Score = 30.0 bits (66), Expect = 5.5, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 94/310 (30%), Gaps = 45/310 (14%) Query: 299 GMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR 358 GM + E + + + + + + L G + + D ++ Sbjct: 72 GMSLHEALAQLQTGVYSGTAMLNRVVQRKGLKCGLIVNRGMEDFHRMGRAVQSHLGYAYE 131 Query: 359 LGLDPTQ---EDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVD-- 413 + + + + + V R+ + + ++E+ + R I D Sbjct: 132 DRIHLNTHRYDPPLVPRHLTRGVVERTDMIGTQVIP-----LREDTARDAARDLIAADAE 186 Query: 414 GSVYKKHPHFAK-RLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYR--LADQHRAR 470 G V + + VR + L + SGK + + Y + HR Sbjct: 187 GIVISLLHSYKNPENERRVRDI-------VLEEVEKSGKKIPVFASADYYPVRKETHRTN 239 Query: 471 QKTLEHL--QLSHDQLLEVKRRMKVEMERGLSKE-----THASA---PVKMLPTYVCATP 520 LE + S L ++ K ERG + TH K L + + P Sbjct: 240 TTILEGYAAEPSRQTLSKISNAFK---ERGTKFDFRVMATHGGTISWKAKELARTIVSGP 296 Query: 521 DGTEKG-----------DFLALDLGGTNFRVLLVRVRNGK-WGGVEMHNKIYAIPQEVMH 568 G G + D+GGT+F V L+ +M + ++P M Sbjct: 297 IGGVIGAKYLGEVLGYKNIACSDIGGTSFDVALITQGEMTIKNDPDMARLVLSLPLVAMD 356 Query: 569 GTGDELFDHI 578 G I Sbjct: 357 SVGAGAGSFI 366 >6G5O-A nrPDB Length = 399 Score = 29.6 bits (65), Expect = 6.3, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 47/121 (38%), Gaps = 13/121 (10%) Query: 278 DQEIDMGSLNPGKQLFEKMISGMYMG-----ELVRLILVKMAKEELLFGGKLSPELLNTG 332 D++ID S NPG ++ +++ + G E V+ ++V + + N+ Sbjct: 177 DEQIDRASENPGDDMYSVLLNSEFEGRKLTKEEVKGVMVLTFAGG---RDTVINAVTNSI 233 Query: 333 RFETKDISDIEG---EKDGIRKAREVLMRLGLDPTQEDCVATH--RICQIVSTRSASLCA 387 + + +E E + +A E ++R TQ V T +C+ + + Sbjct: 234 AYLAEHPEALERLRKEPEITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISL 293 Query: 388 A 388 Sbjct: 294 C 294 >1WZC-A nrPDB Length = 249 Score = 29.6 bits (65), Expect = 6.8, Method: Composition-based stats. Identities = 10/68 (14%), Positives = 29/68 (42%) Query: 19 VQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHG 78 ++++ + + + + +RKE+E + +A+ + + G E G Sbjct: 26 IEELKDMGFEIIFNSSKTRAEQEYYRKELEVETPFISENGSAIFIPKGYFPFDVKGKEVG 85 Query: 79 EFLALDLG 86 ++ ++LG Sbjct: 86 NYIVIELG 93 >4JOD-A nrPDB Length = 396 Score = 29.2 bits (64), Expect = 9.4, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 34/95 (35%), Gaps = 15/95 (15%) Query: 721 FRTEFDVAVDE-------LSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRIS 773 +T+FD V S + + GM+ G++ + + G Sbjct: 53 PQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALG-------- 104 Query: 774 ERLKTRGIFETKFLSQIESDCLALLQVRAILQHLG 808 ERL+ + + FLS + ++ I ++L Sbjct: 105 ERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLE 139 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.315 0.140 0.371 Lambda K H 0.267 0.0427 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 35,190,964 Number of Sequences: 36641 Number of extensions: 1496816 Number of successful extensions: 3996 Number of sequences better than 10.0: 28 Number of HSP's better than 10.0 without gapping: 32 Number of HSP's successfully gapped in prelim test: 15 Number of HSP's that attempted gapping in prelim test: 3718 Number of HSP's gapped (non-prelim): 82 length of query: 917 length of database: 10,336,785 effective HSP length: 106 effective length of query: 811 effective length of database: 6,452,839 effective search space: 5233252429 effective search space used: 5233252429 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 64 (29.2 bits)