BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P52564 (334 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3VN9-A nrPDB 692 0.0 3FME-A nrPDB 594 e-170 3ALO-A nrPDB 364 e-101 5B2L-A nrPDB 277 4e-75 4AN9-A nrPDB 233 8e-62 5KKR-C nrPDB 223 9e-59 3EQC-A nrPDB 221 3e-58 1S9I-A nrPDB 216 1e-56 3COM-A nrPDB 159 2e-39 6AO5-A nrPDB 157 7e-39 4LG4-A nrPDB 157 8e-39 5D7A-A nrPDB 144 5e-35 6HXF-B nrPDB 141 5e-34 5J5T-A nrPDB 132 3e-31 3DAK-A nrPDB 130 1e-30 4QMW-A nrPDB 128 3e-30 2UV2-A nrPDB 127 6e-30 2XIK-A nrPDB 127 7e-30 2WQN-A nrPDB 126 1e-29 4U41-A nrPDB 125 2e-29 6FD3-A nrPDB 122 2e-28 4FZF-B nrPDB 120 7e-28 3Q53-A nrPDB 120 9e-28 4KS7-A nrPDB 119 3e-27 5DBX-A nrPDB 117 5e-27 6CQF-A nrPDB 115 2e-26 6DTL-A nrPDB 109 1e-24 1U5R-A nrPDB 108 3e-24 2GCD-A nrPDB 108 4e-24 2XNP-A nrPDB 105 2e-23 4XBR-A nrPDB 103 1e-22 4FIE-A nrPDB 103 1e-22 4JDH-A nrPDB 103 2e-22 2Q0N-A nrPDB 102 2e-22 4FR4-A nrPDB 102 3e-22 2F57-A nrPDB 101 5e-22 5D9K-A nrPDB 100 1e-21 2Z7Q-A nrPDB 100 1e-21 4UZD-A nrPDB 95 5e-20 2BPM-A nrPDB 94 9e-20 5VD3-A nrPDB 93 2e-19 2PMN-X nrPDB 93 2e-19 5YKS-A nrPDB 93 2e-19 2F9G-A nrPDB 92 2e-19 4I6B-A nrPDB 92 3e-19 4QTB-A nrPDB 91 6e-19 3OHT-A nrPDB 91 9e-19 3IS5-A nrPDB 90 1e-18 3D2K-A nrPDB 90 1e-18 4NEU-A nrPDB 90 2e-18 4APC-A nrPDB 89 2e-18 6GU6-A nrPDB 89 2e-18 6E2O-A nrPDB 89 2e-18 1G3N-A nrPDB 89 3e-18 4MVF-A nrPDB 89 4e-18 4Y93-A nrPDB 88 4e-18 1FOT-A nrPDB 87 7e-18 5O2C-A nrPDB 87 1e-17 4ZSG-A nrPDB 86 2e-17 5O2B-A nrPDB 86 2e-17 4IC8-A nrPDB 86 2e-17 5DYK-A nrPDB 86 2e-17 4AU8-A nrPDB 86 2e-17 3ZDU-A nrPDB 86 2e-17 5X5O-A nrPDB 86 3e-17 4QNY-A nrPDB 86 3e-17 3C51-A nrPDB 86 3e-17 6E4F-A nrPDB 86 3e-17 5WAX-A nrPDB 86 3e-17 5VO2-A nrPDB 86 3e-17 5NGU-A nrPDB 85 4e-17 4XI2-A nrPDB 85 5e-17 5KZ7-A nrPDB 85 5e-17 4L42-A nrPDB 84 7e-17 1VZO-A nrPDB 84 8e-17 3NIZ-A nrPDB 84 9e-17 4RLP-A nrPDB 84 1e-16 2J0K-A nrPDB 84 1e-16 1PHK-A nrPDB 84 1e-16 6ED6-A nrPDB 84 1e-16 4CSV-A nrPDB 84 1e-16 4WNO-A nrPDB 83 2e-16 5ES1-A nrPDB 83 2e-16 4EBW-A nrPDB 82 3e-16 3HDN-A nrPDB 82 3e-16 3A8W-A nrPDB 82 4e-16 4BGQ-A nrPDB 82 4e-16 4M7I-A nrPDB 82 4e-16 3H4J-B nrPDB 81 6e-16 6C9D-A nrPDB 81 7e-16 5KCV-A nrPDB 81 7e-16 6E9W-A nrPDB 81 7e-16 2QNJ-A nrPDB 81 8e-16 4AGU-A nrPDB 81 8e-16 4D28-A nrPDB 81 8e-16 2HAK-A nrPDB 80 9e-16 3MN3-A nrPDB 80 1e-15 5IG1-A nrPDB 80 1e-15 4BBM-A nrPDB 80 1e-15 4XEY-B nrPDB 80 1e-15 4CZT-A nrPDB 80 1e-15 2WTK-B nrPDB 80 1e-15 5FET-A nrPDB 79 2e-15 5AWM-A nrPDB 79 2e-15 5Z33-A nrPDB 79 2e-15 3MV5-A nrPDB 79 2e-15 4E7W-A nrPDB 79 2e-15 6QAU-A nrPDB 79 3e-15 4GS6-A nrPDB 79 3e-15 5UUU-A nrPDB 79 3e-15 4O2Z-A nrPDB 79 3e-15 2JDO-A nrPDB 79 3e-15 2Y7J-A nrPDB 79 3e-15 1UA2-A nrPDB 79 3e-15 2OU7-A nrPDB 79 4e-15 3PVW-A nrPDB 79 4e-15 2FO0-A nrPDB 79 4e-15 4J52-A nrPDB 78 4e-15 3OZ6-A nrPDB 78 6e-15 4KRC-A nrPDB 78 7e-15 5GNK-A nrPDB 78 7e-15 6FDY-U nrPDB 77 7e-15 6NPU-A nrPDB 77 7e-15 3TKU-A nrPDB 77 8e-15 4EWQ-A nrPDB 77 8e-15 3PP0-A nrPDB 77 8e-15 2VN9-A nrPDB 77 9e-15 3BBT-B nrPDB 77 1e-14 5LOH-A nrPDB 77 1e-14 2W96-B nrPDB 77 1e-14 3UC3-A nrPDB 76 2e-14 5MJB-A nrPDB 76 2e-14 1JNK-A nrPDB 76 3e-14 4TNB-A nrPDB 75 3e-14 3LZB-A nrPDB 75 3e-14 3FI2-A nrPDB 75 3e-14 5X3F-B nrPDB 75 4e-14 5N23-A nrPDB 75 4e-14 3GC9-A nrPDB 75 4e-14 6CMJ-A nrPDB 75 4e-14 4WB7-A nrPDB 75 4e-14 4E93-A nrPDB 75 4e-14 4PWN-A nrPDB 75 5e-14 5U6Y-A nrPDB 75 5e-14 3EB0-A nrPDB 75 5e-14 2VZ6-A nrPDB 75 6e-14 3E7O-A nrPDB 75 6e-14 3A4O-X nrPDB 74 6e-14 5AMN-A nrPDB 74 7e-14 2X4F-A nrPDB 74 7e-14 2XS0-A nrPDB 74 7e-14 1CM8-A nrPDB 74 1e-13 3NYO-A nrPDB 73 1e-13 3LIJ-A nrPDB 73 1e-13 2HK5-A nrPDB 73 2e-13 4CFF-A nrPDB 73 2e-13 5YV8-A nrPDB 73 2e-13 5EZV-A nrPDB 73 2e-13 4AW2-A nrPDB 73 2e-13 6BDL-A nrPDB 73 2e-13 4REW-A nrPDB 73 2e-13 4YNZ-A nrPDB 73 2e-13 3PPZ-A nrPDB 73 2e-13 6CCF-A nrPDB 72 2e-13 4RED-A nrPDB 72 3e-13 4CFH-A nrPDB 72 3e-13 5AIR-A nrPDB 72 3e-13 4IDT-A nrPDB 72 3e-13 4JXF-A nrPDB 72 3e-13 2A1A-B nrPDB 72 3e-13 5WNL-A nrPDB 72 4e-13 2VD5-A nrPDB 72 4e-13 3LM0-A nrPDB 72 4e-13 3DB8-A nrPDB 72 4e-13 3SXS-A nrPDB 72 4e-13 4TPT-A nrPDB 72 4e-13 5F9E-A nrPDB 72 4e-13 2PL0-A nrPDB 72 5e-13 2R2P-A nrPDB 71 5e-13 4FG9-A nrPDB 71 5e-13 2YAB-A nrPDB 71 6e-13 5G6V-A nrPDB 71 8e-13 4LRM-A nrPDB 71 8e-13 4B6L-A nrPDB 71 8e-13 3DXN-A nrPDB 71 8e-13 3TXO-A nrPDB 70 9e-13 2YZA-A nrPDB 70 1e-12 1FVR-A nrPDB 70 1e-12 1JPA-A nrPDB 70 1e-12 6GQK-A nrPDB 70 1e-12 3SOA-A nrPDB 70 1e-12 3DKO-A nrPDB 70 1e-12 3UTO-A nrPDB 70 1e-12 4JG6-A nrPDB 70 1e-12 2VWV-A nrPDB 70 2e-12 3BHH-A nrPDB 70 2e-12 4G3E-A nrPDB 70 2e-12 1KOA-A nrPDB 70 2e-12 1AD5-A nrPDB 70 2e-12 3UIU-A nrPDB 70 2e-12 1ZXE-A nrPDB 70 2e-12 1NY3-A nrPDB 70 2e-12 3KN6-A nrPDB 70 2e-12 5J0A-A nrPDB 70 2e-12 5HI2-A nrPDB 69 2e-12 2OZA-A nrPDB 69 2e-12 1K9A-A nrPDB 69 2e-12 3CJF-A nrPDB 69 2e-12 3ZUT-A nrPDB 69 2e-12 3HZT-A nrPDB 69 2e-12 4MYG-A nrPDB 69 2e-12 2Y6O-A nrPDB 69 3e-12 2XYN-A nrPDB 69 3e-12 3KUL-B nrPDB 69 3e-12 2A27-A nrPDB 69 3e-12 5U6B-A nrPDB 69 4e-12 4RA4-A nrPDB 69 4e-12 1V0B-A nrPDB 69 4e-12 3N9X-A nrPDB 69 4e-12 3QGY-A nrPDB 69 4e-12 4XLV-A nrPDB 69 4e-12 4AF3-A nrPDB 68 4e-12 3E3P-A nrPDB 68 4e-12 2BRG-A nrPDB 68 5e-12 4B8L-A nrPDB 68 5e-12 3KA0-A nrPDB 68 5e-12 2V7O-A nrPDB 68 5e-12 3DTC-A nrPDB 68 6e-12 4Y83-A nrPDB 68 6e-12 4UY9-A nrPDB 68 6e-12 5HVK-A nrPDB 68 6e-12 2BDW-A nrPDB 68 6e-12 1ZWS-A nrPDB 68 6e-12 5FG8-A nrPDB 68 6e-12 3ORZ-A nrPDB 68 7e-12 4XUF-A nrPDB 68 7e-12 4F0G-A nrPDB 68 7e-12 3IO7-A nrPDB 67 8e-12 5X02-A nrPDB 67 8e-12 3KK8-A nrPDB 67 8e-12 6BXI-A nrPDB 67 9e-12 2W1I-A nrPDB 67 9e-12 2JC6-A nrPDB 67 9e-12 2W4O-A nrPDB 67 9e-12 4P5Q-A nrPDB 67 1e-11 4LQP-A nrPDB 67 1e-11 5L6P-A nrPDB 67 1e-11 4NIF-A nrPDB 67 1e-11 1U59-A nrPDB 67 1e-11 3UDB-A nrPDB 67 1e-11 5Y86-A nrPDB 67 1e-11 6DBN-A nrPDB 67 2e-11 5XZW-A nrPDB 66 2e-11 2DQ7-X nrPDB 66 2e-11 4RC3-A nrPDB 66 2e-11 5FM2-A nrPDB 66 2e-11 4C59-A nrPDB 66 2e-11 5TUR-A nrPDB 66 2e-11 3BGP-A nrPDB 66 2e-11 3OMV-A nrPDB 66 3e-11 5HIE-A nrPDB 65 3e-11 1BYG-A nrPDB 65 3e-11 6DBM-A nrPDB 65 3e-11 3NCG-A nrPDB 65 3e-11 2OZO-A nrPDB 65 3e-11 4C0T-A nrPDB 65 3e-11 4HVI-A nrPDB 65 4e-11 3HKO-A nrPDB 65 4e-11 5JZN-A nrPDB 65 4e-11 2H8H-A nrPDB 65 4e-11 4UYA-A nrPDB 65 5e-11 3ORP-A nrPDB 65 5e-11 3Q5I-A nrPDB 65 5e-11 5ZTN-A nrPDB 65 5e-11 2ZMD-A nrPDB 65 5e-11 6CTH-A nrPDB 65 6e-11 2BUJ-A nrPDB 65 6e-11 3HMP-A nrPDB 64 7e-11 2Y4I-B nrPDB 64 7e-11 6J5U-C nrPDB 64 7e-11 3HNG-A nrPDB 64 7e-11 4OLI-A nrPDB 64 7e-11 5GRN-A nrPDB 64 7e-11 3NIE-A nrPDB 64 8e-11 3DFA-A nrPDB 64 8e-11 5JN2-A nrPDB 64 8e-11 3MA6-A nrPDB 64 9e-11 5SYS-A nrPDB 64 1e-10 4XCU-A nrPDB 64 1e-10 6F3F-A nrPDB 64 1e-10 4H1J-A nrPDB 64 1e-10 3GUB-A nrPDB 64 1e-10 5AP3-A nrPDB 64 1e-10 2OGV-A nrPDB 64 1e-10 4X7Q-B nrPDB 63 1e-10 4NST-A nrPDB 63 1e-10 5XD6-A nrPDB 63 2e-10 2JAM-A nrPDB 63 2e-10 3TT0-A nrPDB 63 2e-10 6GVJ-A nrPDB 63 2e-10 3GQL-A nrPDB 63 2e-10 5A46-A nrPDB 63 2e-10 4PDS-A nrPDB 63 2e-10 3I6U-A nrPDB 62 2e-10 2YCR-A nrPDB 62 3e-10 4RT7-A nrPDB 62 3e-10 3I81-A nrPDB 62 4e-10 1U54-B nrPDB 62 4e-10 3VHK-A nrPDB 62 4e-10 4HZS-A nrPDB 62 5e-10 5EFQ-A nrPDB 62 5e-10 2PVN-A nrPDB 61 5e-10 3DLS-A nrPDB 61 6e-10 4YFF-A nrPDB 61 6e-10 3QA8-A nrPDB 61 6e-10 3BEA-A nrPDB 61 6e-10 1KOB-A nrPDB 61 7e-10 2HW6-A nrPDB 61 7e-10 6O6Q-A nrPDB 61 8e-10 4RGJ-A nrPDB 61 9e-10 3KRL-A nrPDB 60 1e-09 5E8V-A nrPDB 60 1e-09 4R7H-A nrPDB 60 1e-09 6CKI-A nrPDB 60 1e-09 3QD2-B nrPDB 60 1e-09 3G0E-A nrPDB 60 1e-09 3PFQ-A nrPDB 60 1e-09 3F3Z-A nrPDB 60 1e-09 2I0E-A nrPDB 60 2e-09 2PSQ-A nrPDB 60 2e-09 5AR8-A nrPDB 59 2e-09 3PG1-A nrPDB 59 2e-09 4X3F-A nrPDB 59 2e-09 4KIK-B nrPDB 59 2e-09 6B2Q-A nrPDB 59 4e-09 1PY5-A nrPDB 59 4e-09 4D2V-A nrPDB 59 4e-09 3FXW-A nrPDB 59 4e-09 5EG3-A nrPDB 59 4e-09 4OW8-A nrPDB 59 4e-09 4CQG-A nrPDB 59 4e-09 3TAC-A nrPDB 59 4e-09 2WTK-C nrPDB 58 5e-09 5O0Y-A nrPDB 58 5e-09 5TOS-A nrPDB 58 5e-09 2QKW-B nrPDB 58 5e-09 4PDO-A nrPDB 58 5e-09 1TKI-A nrPDB 58 5e-09 4YHJ-A nrPDB 58 5e-09 6EII-A nrPDB 58 6e-09 4LFI-A nrPDB 57 8e-09 5TE0-A nrPDB 57 1e-08 4K33-A nrPDB 57 1e-08 5X8I-B nrPDB 57 1e-08 4E20-A nrPDB 57 1e-08 4MD7-E nrPDB 57 1e-08 4BTF-A nrPDB 56 3e-08 3MDY-A nrPDB 55 3e-08 6HMD-A nrPDB 55 3e-08 4M69-B nrPDB 55 3e-08 5UIU-A nrPDB 55 4e-08 2I6L-A nrPDB 55 4e-08 4YZB-A nrPDB 55 4e-08 5IKW-A nrPDB 55 5e-08 3MY0-A nrPDB 55 5e-08 3M42-A nrPDB 55 5e-08 5LPZ-A nrPDB 55 5e-08 4EQM-A nrPDB 55 6e-08 4CRL-A nrPDB 55 6e-08 3RP9-A nrPDB 55 6e-08 5CLR-A nrPDB 54 7e-08 3LLT-A nrPDB 54 8e-08 4OAU-C nrPDB 54 8e-08 2RIO-A nrPDB 54 1e-07 3Q4U-A nrPDB 54 1e-07 3LMG-A nrPDB 54 1e-07 3MIA-A nrPDB 53 2e-07 4FL3-A nrPDB 53 2e-07 5LPV-A nrPDB 53 2e-07 5H2U-A nrPDB 53 2e-07 4CRS-A nrPDB 53 2e-07 6BSD-A nrPDB 52 3e-07 6FEX-A nrPDB 52 3e-07 4JLC-A nrPDB 52 3e-07 5C26-A nrPDB 52 3e-07 4OTD-A nrPDB 52 3e-07 5XVU-A nrPDB 52 4e-07 6HV0-A nrPDB 52 4e-07 2H34-A nrPDB 52 5e-07 3RAW-A nrPDB 52 5e-07 6FER-A nrPDB 52 5e-07 6FYV-A nrPDB 51 7e-07 3QUP-A nrPDB 51 7e-07 4EUT-A nrPDB 51 7e-07 6NT9-A nrPDB 51 8e-07 3PLS-A nrPDB 51 8e-07 4MWI-A nrPDB 51 8e-07 2JD5-A nrPDB 51 8e-07 2WO6-A nrPDB 51 9e-07 4EUU-A nrPDB 50 9e-07 6O8B-A nrPDB 50 1e-06 3AOX-A nrPDB 50 1e-06 2CMW-A nrPDB 49 2e-06 3SOC-A nrPDB 49 3e-06 5HLW-A nrPDB 49 3e-06 4L00-A nrPDB 49 3e-06 3UIM-A nrPDB 49 3e-06 4IAN-A nrPDB 49 3e-06 3GC0-A nrPDB 49 3e-06 3ZBF-A nrPDB 49 4e-06 4PL5-B nrPDB 49 4e-06 3C1X-A nrPDB 49 4e-06 4NFN-A nrPDB 48 5e-06 5M07-A nrPDB 48 5e-06 4M66-A nrPDB 48 6e-06 4BTK-A nrPDB 48 7e-06 4CI6-B nrPDB 47 8e-06 2QLU-A nrPDB 47 1e-05 5WNO-A nrPDB 47 2e-05 5UNP-A nrPDB 46 2e-05 3G2F-A nrPDB 46 2e-05 4TN6-A nrPDB 46 3e-05 5U6C-A nrPDB 46 3e-05 4F9B-A nrPDB 45 3e-05 2C47-A nrPDB 45 3e-05 5KMM-A nrPDB 45 4e-05 6DC0-A nrPDB 45 4e-05 5L2Q-C nrPDB 45 4e-05 5CEK-A nrPDB 45 4e-05 2PZI-A nrPDB 45 4e-05 5UV4-A nrPDB 45 5e-05 4Y12-A nrPDB 45 5e-05 4WOV-A nrPDB 44 7e-05 5C01-A nrPDB 44 7e-05 5TQX-A nrPDB 44 9e-05 1LUF-A nrPDB 44 1e-04 3V5Q-A nrPDB 44 1e-04 5FQD-C nrPDB 43 2e-04 4JRN-A nrPDB 42 3e-04 3ZZW-A nrPDB 42 4e-04 4AT3-A nrPDB 42 4e-04 5VC6-A nrPDB 42 5e-04 4XHH-A nrPDB 41 8e-04 5X18-A nrPDB 41 8e-04 6BFN-A nrPDB 40 0.001 4L68-A nrPDB 40 0.001 2CHL-A nrPDB 40 0.001 3SV0-A nrPDB 40 0.001 4WUA-A nrPDB 40 0.002 4NT4-A nrPDB 39 0.003 5VDK-A nrPDB 39 0.003 4O1O-A nrPDB 39 0.005 4I94-A nrPDB 38 0.005 2X7G-A nrPDB 38 0.005 4XHL-A nrPDB 38 0.006 6M7Z-A nrPDB 37 0.014 6EQI-C nrPDB 36 0.023 6J6I-B nrPDB 35 0.035 4AZV-A nrPDB 35 0.037 4AZW-A nrPDB 35 0.043 5DJ3-A nrPDB 33 0.18 2LAV-A nrPDB 33 0.24 2RSV-A nrPDB 33 0.24 3C1D-A nrPDB 31 0.67 1CSN-A nrPDB 31 0.69 1ZD8-A nrPDB 30 1.0 4IX6-A nrPDB 30 1.1 1L1L-A nrPDB 30 1.2 5X1R-A nrPDB 30 1.8 5DMZ-A nrPDB 29 2.6 4J4X-A nrPDB 29 3.5 2WCI-A nrPDB 29 3.5 4EAC-A nrPDB 28 3.9 1YKA-A nrPDB 28 4.5 2AK3-A nrPDB 28 4.6 3BI4-A nrPDB 28 7.6 4FWE-A nrPDB 28 7.9 5YK0-A nrPDB 27 8.4 >3VN9-A nrPDB Length = 340 Score = 692 bits (1787), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/334 (100%), Positives = 334/334 (100%) Query: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG Sbjct: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60 Query: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF Sbjct: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV Sbjct: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 Query: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI Sbjct: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 Query: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK Sbjct: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD Sbjct: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 >3FME-A nrPDB Length = 290 Score = 594 bits (1532), Expect = e-170, Method: Compositional matrix adjust. Identities = 286/290 (98%), Positives = 287/290 (98%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 + EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 60 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD VAK IDAGCKPYMAPER Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPER 180 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS Sbjct: 181 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 240 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD Sbjct: 241 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 290 >3ALO-A nrPDB Length = 327 Score = 364 bits (935), Expect = e-101, Method: Compositional matrix adjust. Identities = 171/293 (58%), Positives = 219/293 (74%), Gaps = 4/293 (1%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 Q+++ A+DL+ + E+GRGAYG V KM H PSGQIMAVKRIR+TV+ +EQK+LLMDLD+ Sbjct: 15 QHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVV 74 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK-GQTIPEDILGKIAVSI 162 MR+ DCP+ V FYGALFREGD WICMELM TS DKFYK V IPE+ILGKI ++ Sbjct: 75 MRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLAT 134 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 VKAL HL L +IHRD+KPSN+L++ G +K+CDFGISG LVDS+AKT DAGC+PYMAP Sbjct: 135 VKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAP 194 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD- 281 ERI+P +++GY V+SD+WSLGIT+ ELA RFPY W + F QL QVV+ PQL Sbjct: 195 ERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSE 254 Query: 282 --KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLIL 332 +FS F++F + CL K+ +RP Y EL++HPF ++E + +VA +V IL Sbjct: 255 EREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKIL 307 >5B2L-A nrPDB Length = 324 Score = 277 bits (709), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 138/297 (46%), Positives = 200/297 (67%), Gaps = 5/297 (1%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98 ++IG Q ++ + +DLE + E+G G G V KMR +G ++AVK++R + N +E KR+LM Sbjct: 5 LTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILM 64 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 DLD+ +++ DCP+ V +G DV+I MELM TS +K K++ IPE ILGK+ Sbjct: 65 DLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRM---QGPIPERILGKM 121 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 V+IVKAL +L K VIHRDVKPSN+L++ GQ+K+CDFGISG LVDS AKT AGC Sbjct: 122 TVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAA 181 Query: 219 YMAPERIN-PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 YMAPERI+ P+ + Y +++D+WSLGI+++ELA +FPY + T F+ L +V++E P Sbjct: 182 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPL 241 Query: 278 LPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG 333 LP FS +F F CL K+ ++RP Y +L++H F +E+ DVAS+ K ++ Sbjct: 242 LPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMA 298 >4AN9-A nrPDB Length = 301 Score = 233 bits (594), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 121/288 (42%), Positives = 181/288 (62%), Gaps = 12/288 (4%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 63 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K Sbjct: 64 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 119 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+D +A G + YM+PER Sbjct: 120 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEF-VGTRSYMSPER- 177 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 L YSV+SDIWS+G++++E+A+ R+P F+ L +V EP P+LP+ FS Sbjct: 178 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAI-FELLDYIVNEPPPKLPSAVFSL 233 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG 333 EF DF ++CL KN ER +LM H F +++ D A ++ +G Sbjct: 234 EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 281 >5KKR-C nrPDB Length = 395 Score = 223 bits (568), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 124/329 (37%), Positives = 186/329 (56%), Gaps = 52/329 (15%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 64 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 122 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K Sbjct: 123 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 178 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER Sbjct: 179 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER- 236 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFP----------------------------- 256 L YSV+SDIWS+G++++E+A+ R+P Sbjct: 237 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 293 Query: 257 -----YDSWGTP-------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 S+G F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 294 TPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERAD 353 Query: 305 YPELMQHPFFTLHESKGTDVASFVKLILG 333 +LM H F +++ D A ++ +G Sbjct: 354 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 382 >3EQC-A nrPDB Length = 360 Score = 221 bits (563), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 123/329 (37%), Positives = 186/329 (56%), Gaps = 52/329 (15%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 87 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P+ V FYGA + +G++ ICME MD SLD QV+ K IPE ILGK++++++K Sbjct: 88 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKKAGRIPEQILGKVSIAVIKG 143 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER Sbjct: 144 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER- 201 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFP----------------------------- 256 L YSV+SDIWS+G++++E+A+ R+P Sbjct: 202 ---LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPR 258 Query: 257 -----YDSWGTP-------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 + +G F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 259 TPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD 318 Query: 305 YPELMQHPFFTLHESKGTDVASFVKLILG 333 +LM H F +++ D A ++ +G Sbjct: 319 LKQLMVHAFIKRSDAEEVDFAGWLCSTIG 347 >1S9I-A nrPDB Length = 354 Score = 216 bits (549), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 121/328 (36%), Positives = 183/328 (55%), Gaps = 56/328 (17%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K++H PSG IMA K I + + +++ +L + + Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHE 70 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P+ V FYGA + +G++ ICME MD SLD QV+ + + IPE+ILGK+++++++ Sbjct: 71 CNSPYIVGFYGAFYSDGEISICMEHMDGGSLD----QVLKEAKRIPEEILGKVSIAVLRG 126 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 L +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YMAPER Sbjct: 127 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER- 184 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDS---------WGTP------------- 263 L YSV+SDIWS+G++++ELA+ R+P +G P Sbjct: 185 ---LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSIS 241 Query: 264 -----------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 F+ L +V EP P+LP F+ +F +F ++CL KN Sbjct: 242 PRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPA 301 Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFV 328 ER L H F E + D A ++ Sbjct: 302 ERADLKMLTNHTFIKRSEVEEVDFAGWL 329 >3COM-A nrPDB Length = 314 Score = 159 bits (402), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 110/309 (35%), Positives = 166/309 (53%), Gaps = 22/309 (7%) Query: 19 AFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI 78 + E Q + P R L S+ Q EV D LE +LG G+YG V K H +GQI Sbjct: 1 SLETVQLRNPPRRQLKKLDEDSLTKQPEEV-FDVLE---KLGEGSYGSVYKAIHKETGQI 56 Query: 79 MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLD 137 +A+K++ + QE ++ ++ I M+ D P V +YG+ F+ D+WI ME S+ Sbjct: 57 VAIKQVPVESDLQE---IIKEISI-MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS 112 Query: 138 KFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 + + +T+ ED + I S +K LE+LH + IHRD+K N+L+N G K+ D Sbjct: 113 DIIRL---RNKTLTEDEIATILQSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLAD 168 Query: 198 FGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP 256 FG++G L D++AK P+ MAPE I + GY+ +DIWSLGIT IE+A + P Sbjct: 169 FGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITAIEMAEGKPP 224 Query: 257 YDSWGTPFQQLKQVVEEPSPQL-PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 Y P + + + P P + +S F DF QCL K+ ++R T +L+QHPF Sbjct: 225 YADIH-PMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPF-- 281 Query: 316 LHESKGTDV 324 + +KG + Sbjct: 282 VRSAKGVSI 290 >6AO5-A nrPDB Length = 362 Score = 157 bits (396), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 95/260 (36%), Positives = 148/260 (56%), Gaps = 16/260 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +LG G+YG V K H SGQ++A+K++ + QE ++ ++ I M+ D P+ V +YG Sbjct: 17 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE---IIKEISI-MQQCDSPYVVKYYG 72 Query: 118 ALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + F+ D+WI ME S+ + + +T+ ED + I S +K LE+LH + I Sbjct: 73 SYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLIEDEIATILKSTLKGLEYLHF-MRKI 128 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYS 235 HR++K N+L+N G K+ DFG++G L D++AK P+ MAPE I + GY+ Sbjct: 129 HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYN 184 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL-PADKFSAEFVDFTSQC 294 +DIWSLGIT IE+A + PY P + + + P P + +S +F DF +C Sbjct: 185 CVADIWSLGITSIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC 243 Query: 295 LKKNSKERPTYPELMQHPFF 314 L KN ++R T +L+QHPF Sbjct: 244 LVKNPEQRATATQLLQHPFI 263 >4LG4-A nrPDB Length = 299 Score = 157 bits (396), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 95/260 (36%), Positives = 148/260 (56%), Gaps = 16/260 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +LG G+YG V K H SGQ++A+K++ + QE ++ ++ I M+ D P+ V +YG Sbjct: 18 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE---IIKEISI-MQQCDSPYVVKYYG 73 Query: 118 ALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + F+ D+WI ME S+ + + +T+ ED + I S +K LE+LH + I Sbjct: 74 SYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLIEDEIATILKSTLKGLEYLHF-MRKI 129 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYS 235 HR++K N+L+N G K+ DFG++G L D++AK P+ MAPE I + GY+ Sbjct: 130 HRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYN 185 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL-PADKFSAEFVDFTSQC 294 +DIWSLGIT IE+A + PY P + + + P P + +S +F DF +C Sbjct: 186 CVADIWSLGITSIEMAEGKPPYADI-HPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC 244 Query: 295 LKKNSKERPTYPELMQHPFF 314 L KN ++R T +L+QHPF Sbjct: 245 LVKNPEQRATATQLLQHPFI 264 >5D7A-A nrPDB Length = 308 Score = 144 bits (363), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 94/271 (34%), Positives = 140/271 (51%), Gaps = 15/271 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 E + +G G YG V K RHV +GQ+ A+K + T + +E+ + ++++ + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNI 76 Query: 113 VTFYGALFREG------DVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 T+YGA ++ +W+ ME S+ K KG T+ E+ + I I++ Sbjct: 77 ATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KGNTLKEEWIAYICREILRG 134 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPER 224 L HLH VIHRD+K NVL+ +VK+ DFG+S L +V + PY MAPE Sbjct: 135 LSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV 193 Query: 225 INPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF 283 I + N Y KSD+WSLGIT IE+A P P + L + P+P+L + K+ Sbjct: 194 IACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKW 252 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S +F F CL KN +RP +LM+HPF Sbjct: 253 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 283 >6HXF-B nrPDB Length = 302 Score = 141 bits (355), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 93/281 (33%), Positives = 150/281 (53%), Gaps = 13/281 (4%) Query: 43 NQNFEVKADDLEP------IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 ++ +E DL+P + ELG GA+G V K ++ +G + A K I T + +E + Sbjct: 5 SREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDY 63 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 +++++I + T D P+ V GA + +G +WI +E +D+G T P+ + Sbjct: 64 IVEIEI-LATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ--IQ 120 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216 + +++AL LHSK +IHRD+K NVL+ G +++ DFG+S + ++ K Sbjct: 121 VVCRQMLEALNFLHSK-RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIG 179 Query: 217 KPY-MAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 PY MAPE + E + Y K+DIWSLGIT+IE+A + P+ LK +P Sbjct: 180 TPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDP 239 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 L K+S EF DF L KN + RP+ +L++HPF + Sbjct: 240 PTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVS 280 >5J5T-A nrPDB Length = 370 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 93/276 (33%), Positives = 143/276 (51%), Gaps = 16/276 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 +D E I +G G YG V K R+V +G++ A+K I+ + E ++ I M+ P Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK--LEPGEDFAVVQQEIIMMKDCKHP 61 Query: 111 FTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V ++G+ R +WICME SL Y + E + ++ ++ L +L Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT----GPLSELQIAYVSRETLQGLYYL 117 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPE 228 HSK +HRD+K +N+L+ G VK+ DFG+S + ++AK PY MAPE E Sbjct: 118 HSK-GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE 176 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFP-YDSWGTPFQQLKQVVE---EPSPQLPADKFS 284 + GY+ D+W++GIT IELA L+ P +D P + L + + +P K+S Sbjct: 177 -RKGGYNQLCDLWAVGITAIELAELQPPMFDL--HPMRALFLMTKSNFQPPKLKDKMKWS 233 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 F F L KN K+RPT +L+QHPF T H ++ Sbjct: 234 NSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR 269 >3DAK-A nrPDB Length = 290 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 90/289 (31%), Positives = 141/289 (48%), Gaps = 27/289 (9%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 + + DD E +G GA VV+ P + +A+KRI LL ++ +M Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQ-AMS 63 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQ----TIPEDILGKIAV 160 P V++Y + + ++W+ M+L+ S+ K ++ KG+ + E + I Sbjct: 64 QCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-------DSVAKTID 213 +++ LE+LH K IHRDVK N+L+ G V++ DFG+S +L + V KT Sbjct: 124 EVLEGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF- 181 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G +MAPE + +GY K+DIWS GIT IELA PY + P + L ++ Sbjct: 182 VGTPCWMAPEVME---QVRGYDFKADIWSFGITAIELATGAAPYHKY-PPMKVLMLTLQN 237 Query: 274 PSPQLPA--------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 P L K+ F S CL+K+ ++RPT EL++H FF Sbjct: 238 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF 286 >4QMW-A nrPDB Length = 310 Score = 128 bits (322), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 89/291 (30%), Positives = 150/291 (51%), Gaps = 18/291 (6%) Query: 42 GNQNFEVKADDLEPIME-LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 G QN + ++L +E +G+G++G V K + +++A+K I E + + ++ Sbjct: 19 GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 78 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMD--TSLDKFYKQVIDKGQTIPEDILGKI 158 + + D P+ +YG+ ++ +WI ME + ++LD +D+ Q + I Sbjct: 79 TV-LSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IATI 131 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-VAKTIDAGCK 217 I+K L++LHS+ IHRD+K +NVL++ G+VK+ DFG++G L D+ + + G Sbjct: 132 LREILKGLDYLHSE-KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTP 190 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 +MAPE I Q Y K+DIWSLGIT IELA P+ P + L + + P Sbjct: 191 FWMAPEVI----KQSAYDSKADIWSLGITAIELARGEPPHSEL-HPMKVLFLIPKNNPPT 245 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 L + +S +F CL K RPT EL++H F + K + + + Sbjct: 246 LEGN-YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI 295 >2UV2-A nrPDB Length = 325 Score = 127 bits (319), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 84/274 (30%), Positives = 148/274 (54%), Gaps = 11/274 (4%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D E I ELG GA+G V K ++ + ++A ++ T + +E + ++++DI + + D P Sbjct: 37 DFWEIIGELGDGAFGKVYKAQNKETS-VLAAAKVIDTKSEEELEDYMVEIDI-LASCDHP 94 Query: 111 FTVTFYGALFREGDVWICMEL-MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V A + E ++WI +E ++D +++ + + E + + + AL +L Sbjct: 95 NIVKLLDAFYYENNLWILIEFCAGGAVDAV---MLELERPLTESQIQVVCKQTLDALNYL 151 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPE 228 H +IHRD+K N+L G +K+ DFG+S ++ + PY MAPE + E Sbjct: 152 HDN-KIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCE 210 Query: 229 LNQ-KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAE 286 ++ + Y K+D+WSLGIT+IE+A + P+ P + L ++ + P L ++S+ Sbjct: 211 TSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN-PMRVLLKIAKSEPPTLAQPSRWSSN 269 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 F DF +CL+KN R T +L+QHPF T+ +K Sbjct: 270 FKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNK 303 >2XIK-A nrPDB Length = 294 Score = 127 bits (319), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 90/292 (30%), Positives = 152/292 (52%), Gaps = 18/292 (6%) Query: 41 IGNQNFEVKADDLEPIME-LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 NQ+ V ++L ++ +G+G++G V K + +++A+K I E + + + Sbjct: 8 FANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQE 67 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMD--TSLDKFYKQVIDKGQTIPEDILGK 157 + + + D P+ ++G+ + +WI ME + ++LD + K + E + Sbjct: 68 ITV-LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALD------LLKPGPLEETYIAT 120 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-VAKTIDAGC 216 I I+K L++LHS+ IHRD+K +NVL++ G VK+ DFG++G L D+ + + G Sbjct: 121 ILREILKGLDYLHSERK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGT 179 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP 276 +MAPE I Q Y K+DIWSLGIT IELA P +S P + L + + P Sbjct: 180 PFWMAPEVI----KQSAYDFKADIWSLGITAIELAKGE-PPNSDLHPMRVLFLIPKNSPP 234 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 L + S F +F CL K+ + RPT EL++H F T + K + + + Sbjct: 235 TLEG-QHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELI 285 >2WQN-A nrPDB Length = 310 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 84/297 (28%), Positives = 153/297 (51%), Gaps = 25/297 (8%) Query: 12 GLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR 71 G++ P QPQ + P ++ A NF ++ ++GRG + V + Sbjct: 7 GMQGPPVPQFQPQKALRPDMGYNTLA-------NFRIEK-------KIGRGQFSEVYRAA 52 Query: 72 HVPSGQIMAVKRIRA--TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICM 129 + G +A+K+++ ++++ + + ++D+ ++ ++ P + +Y + + ++ I + Sbjct: 53 CLLDGVPVALKKVQIFDLMDAKARADCIKEIDL-LKQLNHPNVIKYYASFIEDNELNIVL 111 Query: 130 ELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN 188 EL D L + K + + IPE + K V + ALEH+HS+ V+HRD+KP+NV I Sbjct: 112 ELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSR-RVMHRDIKPANVFIT 170 Query: 189 ALGQVKMCDFGISGYLVD-SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 A G VK+ D G+ + + A G YM+PERI ++ GY+ KSDIWSLG + Sbjct: 171 ATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI----HENGYNFKSDIWSLGCLL 226 Query: 248 IELAILRFP-YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 E+A L+ P Y + K++ + P LP+D +S E + C+ + ++RP Sbjct: 227 YEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRP 283 >4U41-A nrPDB Length = 332 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 97/292 (33%), Positives = 149/292 (51%), Gaps = 15/292 (5%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91 D +K+ + I + A E + +G G YG V K RHV +GQ+ A+K + T + + Sbjct: 5 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 64 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDT-SLDKFYKQVI 144 E+ +L ++++ + T+YGA ++ +W+ ME S+ K Sbjct: 65 EEIKL--EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT- 121 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 KG T+ ED + I+ I++ L HLH VIHRD+K NVL+ +VK+ DFG+S L Sbjct: 122 -KGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQL 179 Query: 205 VDSVAKTIDAGCKPY-MAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGT 262 +V + PY MAPE I + N Y +SD+WS GIT IE+A P Sbjct: 180 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDM-H 238 Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 P + L + P P+L + K+S +F F CL KN +RP+ +L++HPF Sbjct: 239 PMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 290 >6FD3-A nrPDB Length = 300 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 85/263 (32%), Positives = 135/263 (51%), Gaps = 18/263 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ++G+GA G V + +GQ +A+K++ + Q +K L+++ + MR P V + Sbjct: 29 KIGQGASGTVYTALDIATGQEVAIKQM--NLQQQPKKELIINEILVMRENKNPNIVNYLD 86 Query: 118 ALFREGDVWICME-LMDTSL-DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ++W+ ME L SL D + +D+GQ + + ++AL+ LHS V Sbjct: 87 SYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQ------IAAVCRECLQALDFLHSN-QV 139 Query: 176 IHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGY 234 IHRD+K N+L+ G VK+ DFG + +K PY MAPE + +K Y Sbjct: 140 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV----TRKAY 195 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQ 293 K DIWSLGI IE+ PY + P + L + +P+L ++ SA F DF ++ Sbjct: 196 GPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPERLSAVFRDFLNR 254 Query: 294 CLKKNSKERPTYPELMQHPFFTL 316 CL+ + R + EL+QHPF L Sbjct: 255 CLEMDVDRRGSAKELLQHPFLKL 277 >4FZF-B nrPDB Length = 283 Score = 120 bits (302), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 85/273 (31%), Positives = 139/273 (50%), Gaps = 17/273 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G+G++G V K + Q++A+K I E + + ++ + + D + +YG+ Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV-LSQCDSSYVTKYYGS 74 Query: 119 LFREGDVWICMELMD--TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + +WI ME + ++LD D+ Q + + I+K L++LHS+ I Sbjct: 75 YLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ------IATMLKEILKGLDYLHSE-KKI 127 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDS-VAKTIDAGCKPYMAPERINPELNQKGYS 235 HRD+K +NVL++ G VK+ FG++G L D+ + + G +MAPE I Q Y Sbjct: 128 HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI----QQSAYD 183 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 K+DIWSLGIT IELA P +S P + L + + P L D F+ F +F CL Sbjct: 184 SKADIWSLGITAIELAKGE-PPNSDMHPMRVLFLIPKNNPPTLVGD-FTKSFKEFIDACL 241 Query: 296 KKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 K+ RPT EL++H F + K + + + Sbjct: 242 NKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 274 >3Q53-A nrPDB Length = 306 Score = 120 bits (300), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 85/263 (32%), Positives = 136/263 (51%), Gaps = 18/263 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ++G+GA G V V +GQ +A++++ + Q +K L+++ + MR P V + Sbjct: 28 KIGQGASGTVYTAMDVATGQEVAIRQM--NLQQQPKKELIINEILVMRENKNPNIVNYLD 85 Query: 118 ALFREGDVWICME-LMDTSL-DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ++W+ ME L SL D + +D+GQ + + ++ALE LHS V Sbjct: 86 SYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQ------IAAVCRECLQALEFLHSN-QV 138 Query: 176 IHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGY 234 IHRD+K N+L+ G VK+ DFG + +K PY MAPE + +K Y Sbjct: 139 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV----TRKAY 194 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQ 293 K DIWSLGI IE+ PY + P + L + +P+L +K SA F DF ++ Sbjct: 195 GPKVDIWSLGIMAIEMIEGEPPYLN-ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR 253 Query: 294 CLKKNSKERPTYPELMQHPFFTL 316 CL+ + ++R + EL+QH F + Sbjct: 254 CLEMDVEKRGSAKELIQHQFLKI 276 >4KS7-A nrPDB Length = 292 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 84/265 (31%), Positives = 140/265 (52%), Gaps = 16/265 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +++G G+ G+V R SG+ +AVK + + Q+++ LL + + MR Sbjct: 25 LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMRDYQHFNV 82 Query: 113 VTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V Y + ++W+ ME + +L QV + E+ + + ++++AL +LH+ Sbjct: 83 VEMYKSYLVGEELWVLMEFLQGGALTDIVSQV-----RLNEEQIATVCEAVLQALAYLHA 137 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELN 230 + VIHRD+K ++L+ G+VK+ DFG + V K PY MAPE I+ L Sbjct: 138 Q-GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL- 195 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVD 289 Y+ + DIWSLGI +IE+ PY S +P Q +K++ + P P+L + K S D Sbjct: 196 ---YATEVDIWSLGIMVIEMVDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSHKVSPVLRD 251 Query: 290 FTSQCLKKNSKERPTYPELMQHPFF 314 F + L ++ +ER T EL+ HPF Sbjct: 252 FLERMLVRDPQERATAQELLDHPFL 276 >5DBX-A nrPDB Length = 328 Score = 117 bits (294), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 133/275 (48%), Gaps = 25/275 (9%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G GA VV+ P + +A+KRI LL ++ +M P VT+Y + Sbjct: 19 IGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQ-AMSQCSHPNVVTYYTS 77 Query: 119 LFREGDVWICMELMDT-SLDKFYKQVIDKGQ----TIPEDILGKIAVSIVKALEHLHSKL 173 + ++W+ M+L+ S+ K ++++G+ + E I+ I +++ L++LH Sbjct: 78 FVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN- 136 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID------AGCKPYMAPERINP 227 IHRD+K N+L+ G V++ DFG+S +L T + G +MAPE + Sbjct: 137 GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVME- 195 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA------- 280 +GY K+D+WS GIT IELA PY + P + L ++ P L Sbjct: 196 --QVRGYDFKADMWSFGITAIELATGAAPYHKY-PPMKVLMLTLQNDPPTLETGVEDKEM 252 Query: 281 -DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 K+ F S CL+K+ +RPT EL++ FF Sbjct: 253 MKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFF 287 >6CQF-A nrPDB Length = 297 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 88/274 (32%), Positives = 142/274 (51%), Gaps = 22/274 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN---SQEQKRLLMDLDISMRTV 107 D + + LG G YG V K R SG ++A+K ++ + S QK +L+ ++T Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILI-----LKTC 70 Query: 108 DCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V ++G+ +WICME SL Y+ ++ E + + +++ L Sbjct: 71 RHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT----GSLSELQISYVCREVLQGL 126 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERI 225 +LHS+ IHRD+K +N+LIN G+V++ DFGIS + ++A+ + PY MAPE Sbjct: 127 AYLHSQ-KKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVA 185 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFP-YDSWGTPFQQLKQVVE---EPSPQLPAD 281 L + GY+ DIWSLGIT IELA L+ P +D P + L + + +P Sbjct: 186 AVAL-KGGYNELCDIWSLGITAIELAELQPPLFDV--HPLRVLFLMTKSGYQPPRLKEKG 242 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 K+SA F +F L K+ K+RP+ +++ H + Sbjct: 243 KWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVS 276 >6DTL-A nrPDB Length = 364 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/307 (29%), Positives = 147/307 (47%), Gaps = 43/307 (14%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISM 104 FEV A PIM +G+GAYG+V + + + +A+K+I A N + KR L ++ + + Sbjct: 25 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKL-L 83 Query: 105 RTVDCPFTVTFYGAL---FREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 R +D V + R DV+I ELMDT L Q+I Q + E+ Sbjct: 84 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL----HQIIRSNQALSEEHCQYFL 139 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 I++ L+++HS +V+HRD+KPSN+L+NA +K+CDFG++ +S T + Y Sbjct: 140 YQILRGLKYIHSA-NVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 198 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSP- 276 APE + LN Y+ D+WS+G +EL + FP + L +++ PS Sbjct: 199 RAPELL---LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 255 Query: 277 --------------QLP-------ADKFSAEF---VDFTSQCLKKNSKERPTYPELMQHP 312 QLP DKF +D + L + + R T + + HP Sbjct: 256 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 315 Query: 313 FF-TLHE 318 + +LH+ Sbjct: 316 YLNSLHD 322 >1U5R-A nrPDB Length = 348 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 75/259 (28%), Positives = 133/259 (51%), Gaps = 10/259 (3%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVT 114 + E+G G++G V R V + +++A+K++ + +K + ++ ++ + P T+ Sbjct: 59 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 118 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + G RE W+ ME S + + K + + E + + ++ L +LHS + Sbjct: 119 YRGCYLREHTAWLVMEYCLGSASDLLE--VHK-KPLQEVEIAAVTHGALQGLAYLHSH-N 174 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 +IHRDVK N+L++ G VK+ DFG + + + + G +MAPE I +++ Y Sbjct: 175 MIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFV---GTPYWMAPEVI-LAMDEGQY 230 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 K D+WSLGIT IELA + P + L + + SP L + +S F +F C Sbjct: 231 DGKVDVWSLGITCIELAERKPPLFNMNA-MSALYHIAQNESPALQSGHWSEYFRNFVDSC 289 Query: 295 LKKNSKERPTYPELMQHPF 313 L+K ++RPT L++H F Sbjct: 290 LQKIPQDRPTSEVLLKHRF 308 >2GCD-A nrPDB Length = 309 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 75/259 (28%), Positives = 133/259 (51%), Gaps = 10/259 (3%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVT 114 + E+G G++G V R V + +++A+K++ + +K + ++ ++ + P T+ Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQ 79 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + G RE W+ ME S + + K + + E + + ++ L +LHS + Sbjct: 80 YRGCYLREHTAWLVMEYCLGSASDLLE--VHK-KPLQEVEIAAVTHGALQGLAYLHSH-N 135 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 +IHRDVK N+L++ G VK+ DFG + + + + G +MAPE I +++ Y Sbjct: 136 MIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFV---GTPYWMAPEVI-LAMDEGQY 191 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 K D+WSLGIT IELA + P + L + + SP L + +S F +F C Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFNMNA-MSALYHIAQNESPALQSGHWSEYFRNFVDSC 250 Query: 295 LKKNSKERPTYPELMQHPF 313 L+K ++RPT L++H F Sbjct: 251 LQKIPQDRPTSEVLLKHRF 269 >2XNP-A nrPDB Length = 279 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 76/277 (27%), Positives = 140/277 (50%), Gaps = 22/277 (7%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 +A+D E + +G G+YG +K+R G+I+ K + ++ +K++L+ +R + Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 109 CPFTVTFYGALFREGD--VWICMELMDTSLDKFYKQVIDKG----QTIPEDILGKIAVSI 162 P V +Y + + ++I ME + VI KG Q + E+ + ++ + Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGG---DLASVITKGTKERQYLDEEFVLRVMTQL 120 Query: 163 VKALEHLHSK----LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGC 216 AL+ H + +V+HRD+KP+NV ++ VK+ DFG++ L S AKT G Sbjct: 121 TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTF-VGT 179 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP 276 YM+PE ++N+ Y+ KSDIWSLG + EL L P+ ++ ++L + E Sbjct: 180 PYYMSPE----QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQ--KELAGKIREGKF 233 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 + ++S E + ++ L RP+ E++++P Sbjct: 234 RRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270 >4XBR-A nrPDB Length = 366 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 78/281 (27%), Positives = 142/281 (50%), Gaps = 18/281 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +++G G+ G+V SG+++AVK++ + Q+++ LL + + MR Sbjct: 96 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENV 153 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V Y + ++W+ ME ++ ++ + + E+ + + +++++AL LH++ Sbjct: 154 VEMYNSYLVGDELWVVMEFLEGGA---LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 209 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQ 231 VIHRD+K ++L+ G+VK+ DFG + V + PY MAPE I ++ Sbjct: 210 -GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI----SR 264 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDF 290 Y + DIWSLGI +IE+ PY + P + +K + + P+L K S F Sbjct: 265 LPYGPEVDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGF 323 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 + L ++ +R T EL++HPF +K AS V L+ Sbjct: 324 LDRLLVRDPAQRATAAELLKHPFL----AKAGPPASIVPLM 360 >4FIE-A nrPDB Length = 423 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 78/281 (27%), Positives = 142/281 (50%), Gaps = 18/281 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +++G G+ G+V SG+++AVK++ + Q+++ LL + + MR Sbjct: 153 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENV 210 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V Y + ++W+ ME ++ ++ + + E+ + + +++++AL LH++ Sbjct: 211 VEMYNSYLVGDELWVVMEFLEGGA---LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 266 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQ 231 VIHRD+K ++L+ G+VK+ DFG + V + PY MAPE I ++ Sbjct: 267 -GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI----SR 321 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDF 290 Y + DIWSLGI +IE+ PY + P + +K + + P+L K S F Sbjct: 322 LPYGPEVDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGF 380 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 + L ++ +R T EL++HPF +K AS V L+ Sbjct: 381 LDRLLVRDPAQRATAAELLKHPFL----AKAGPPASIVPLM 417 >4JDH-A nrPDB Length = 346 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 79/282 (28%), Positives = 141/282 (50%), Gaps = 20/282 (7%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +++G G+ G+V SG+++AVK++ + Q+++ LL + + MR Sbjct: 76 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENV 133 Query: 113 VTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V Y + ++W+ ME ++ +L + E+ + + +++++AL LH+ Sbjct: 134 VEMYNSYLVGDELWVVMEFLEGGALTDIVTHT-----RMNEEQIAAVCLAVLQALSVLHA 188 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELN 230 + VIHRD+K ++L+ G+VK+ DFG + V + PY MAPE I + Sbjct: 189 Q-GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI----S 243 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVD 289 + Y + DIWSLGI +IE+ PY + P + +K + + P+L K S Sbjct: 244 RLPYGPEVDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKG 302 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 F + L ++ +R T EL++HPF +K AS V L+ Sbjct: 303 FLDRLLVRDPAQRATAAELLKHPFL----AKAGPPASIVPLM 340 >2Q0N-A nrPDB Length = 301 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/281 (27%), Positives = 142/281 (50%), Gaps = 18/281 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +++G G+ G+V SG+++AVK++ + Q+++ LL + + MR Sbjct: 31 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENV 88 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V Y + ++W+ ME ++ ++ + + E+ + + +++++AL LH++ Sbjct: 89 VEMYNSYLVGDELWVVMEFLEGGA---LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ 144 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQ 231 VIHRD+K ++L+ G+VK+ DFG + V + PY MAPE I ++ Sbjct: 145 -GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI----SR 199 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDF 290 Y + DIWSLGI +IE+ PY + P + +K + + P+L K S F Sbjct: 200 LPYGPEVDIWSLGIMVIEMVDGEPPYFN-EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGF 258 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 + L ++ +R T EL++HPF +K AS V L+ Sbjct: 259 LDRLLVRDPAQRATAAELLKHPFL----AKAGPPASIVPLM 295 >4FR4-A nrPDB Length = 384 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 74/265 (27%), Positives = 133/265 (50%), Gaps = 10/265 (3%) Query: 41 IGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLM 98 + ++N +V D E + +G+G++G V ++ + ++ A+K + + V E + + Sbjct: 5 VFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFK 64 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 +L I M+ ++ PF V + + E D+++ ++L+ +++ Q + E+ + Sbjct: 65 ELQI-MQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ---QNVHFKEETVKLF 120 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 +V AL++L ++ +IHRD+KP N+L++ G V + DF I+ L T AG KP Sbjct: 121 ICELVMALDYLQNQ-RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKP 179 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD-SWGTPFQQLKQVVEEPSPQ 277 YMAPE + GYS D WSLG+T EL R PY T +++ E Sbjct: 180 YMAPEMFSSR-KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVT 238 Query: 278 LPADKFSAEFVDFTSQCLKKNSKER 302 P+ +S E V + L+ N +R Sbjct: 239 YPS-AWSQEMVSLLKKLLEPNPDQR 262 >2F57-A nrPDB Length = 317 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 135/266 (50%), Gaps = 14/266 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L +++G G+ G+V +G+ +AVK++ + Q+++ LL + + MR Sbjct: 47 LANFIKIGEGSTGIVCIATEKHTGKQVAVKKM--DLRKQQRRELLFNEVVIMRDYHHDNV 104 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V Y + ++W+ ME ++ ++ + + E+ + + +S+++AL +LH++ Sbjct: 105 VDMYSSYLVGDELWVVMEFLEGGA---LTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQ 160 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQ 231 VIHRD+K ++L+ + G++K+ DFG + V K PY MAPE I ++ Sbjct: 161 -GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI----SR 215 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDF 290 Y + DIWSLGI +IE+ PY + P Q ++++ + P++ K S+ F Sbjct: 216 LPYGTEVDIWSLGIMVIEMIDGEPPYFN-EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGF 274 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTL 316 L + +R T EL+ HPF L Sbjct: 275 LDLMLVREPSQRATAQELLGHPFLKL 300 >5D9K-A nrPDB Length = 330 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 71/243 (29%), Positives = 128/243 (52%), Gaps = 20/243 (8%) Query: 22 QPQTSSTPPRDLDSKACISIGNQNFEVKAD--DLEPIMELGRGAYG---VVEKMRHVPSG 76 PQT +++ + G++ KAD E + LG+G++G +V+K+ + Sbjct: 3 NPQTEEVSIKEIAITHHVKEGHE----KADPSQFELLKVLGQGSFGKVFLVKKISGSDAR 58 Query: 77 QIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS 135 Q+ A+K ++ AT+ +++ R M+ DI + V+ PF V + A EG +++ ++ + Sbjct: 59 QLYAMKVLKKATLKVRDRVRTKMERDI-LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG 117 Query: 136 LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKM 195 D F + + K E+ + + AL+HLHS L +I+RD+KP N+L++ G +K+ Sbjct: 118 -DLFTR--LSKEVMFTEEDVKFYLAELALALDHLHS-LGIIYRDLKPENILLDEEGHIKL 173 Query: 196 CDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 254 DFG+S +D K G YMAPE + N++G++ +D WS G+ M E+ Sbjct: 174 TDFGLSKESIDHEKKAYSFCGTVEYMAPEVV----NRRGHTQSADWWSFGVLMFEMLTGT 229 Query: 255 FPY 257 P+ Sbjct: 230 LPF 232 >2Z7Q-A nrPDB Length = 321 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 116/216 (53%), Gaps = 16/216 (7%) Query: 49 KAD--DLEPIMELGRGAYGVVEKMRHVP---SGQIMAVKRIR-ATVNSQEQKRLLMDLDI 102 KAD E + LG+G++G V +R V SG + A+K ++ AT+ +++ R M+ DI Sbjct: 24 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDI 83 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + V+ PF V + A EG +++ ++ + D F + + K E+ + + Sbjct: 84 -LADVNHPFVVKLHYAFQTEGKLYLILDFLRGG-DLFTR--LSKEVMFTEEDVKFYLAEL 139 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMA 221 L+HLHS L +I+RD+KP N+L++ G +K+ DFG+S +D K G YMA Sbjct: 140 ALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMA 198 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 PE + N++G+S +D WS G+ M E+ P+ Sbjct: 199 PEVV----NRQGHSHSADWWSYGVLMFEMLTGSLPF 230 >4UZD-A nrPDB Length = 287 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 76/277 (27%), Positives = 132/277 (47%), Gaps = 19/277 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNS---QEQKRLLMDLDISMRT 106 +D E LG+G +G V R S I+A+K + +A + + Q R +++ +R Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 P + YG V++ +E L Y++ + K E + AL Sbjct: 68 ---PNILRLYGYFHDATRVYLILEY--APLGTVYRE-LQKLSKFDEQRTATYITELANAL 121 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 + HSK VIHRD+KP N+L+ + G++K+ DFG S + S +T G Y+ PE I Sbjct: 122 SYCHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIE 179 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 ++ + K D+WSLG+ E + + P+++ +Q+ + + P D + Sbjct: 180 GRMHDE----KVDLWSLGVLCYEFLVGKPPFEA--NTYQETYKRISRVEFTFP-DFVTEG 232 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 D S+ LK N +RP E+++HP+ T + SK ++ Sbjct: 233 ARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSN 269 >2BPM-A nrPDB Length = 309 Score = 93.6 bits (231), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 105/215 (48%), Gaps = 9/215 (4%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107 V ++ + + ++G G YGVV K R+ +G+++A+K+IR ++ + ++ + Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 63 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + P V + E +++ E + L KF G IP ++ +++ L Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLA 121 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPERIN 226 HS V+HRD+KP N+LIN G +K+ DFG++ + V T + Y APE + Sbjct: 122 FCHSH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL- 179 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILR--FPYDS 259 L K YS DIWSLG E+ R FP DS Sbjct: 180 --LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDS 212 >5VD3-A nrPDB Length = 311 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 125/259 (48%), Gaps = 16/259 (6%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-QEQKRLLMDLDISMRTVDCPFTVT 114 + LG G+YG V K+R G++ AVKR + +++ R L ++ + P V Sbjct: 62 LSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVR 121 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 A G +++ EL SL + + G ++PE + + AL HLHS+ Sbjct: 122 LEQAWEEGGILYLQTELCGPSLQQHCEAW---GASLPEAQVWGYLRDTLLALAHLHSQ-G 177 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 ++H DVKP+N+ + G+ K+ DFG+ L + A + G YMA PEL Q Y Sbjct: 178 LVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMA-----PELLQGSY 232 Query: 235 SVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQ 293 +D++SLG+T++E+A + P+ G +QQL+Q P+ A S+E Sbjct: 233 GTAADVFSLGLTILEVACNMELPHG--GEGWQQLRQGYL--PPEFTAG-LSSELRSVLVM 287 Query: 294 CLKKNSKERPTYPELMQHP 312 L+ + K R T L+ P Sbjct: 288 MLEPDPKLRATAEALLALP 306 >2PMN-X nrPDB Length = 348 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/242 (30%), Positives = 118/242 (48%), Gaps = 29/242 (11%) Query: 111 FTVTFYGALFREGDVWICMELMDT-SLDKF--YKQVIDKGQT--IPEDILGKIAVSIVKA 165 + +T G + +V+I E M+ S+ KF Y V+DK T IP ++ I S++ + Sbjct: 104 YCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNS 163 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 ++H++ ++ HRDVKPSN+L++ G+VK+ DFG S Y+VD K G +M PE Sbjct: 164 FSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKG-SRGTYEFMPPEFF 222 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK--- 282 + E + G K DIWSLGI + + P+ S +L + + + P D+ Sbjct: 223 SNESSYNG--AKVDIWSLGICLYVMFYNVVPF-SLKISLVELFNNIRTKNIEYPLDRNHF 279 Query: 283 ---------------FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASF 327 S E +DF L+KN ER T + ++H + L ++ D+ F Sbjct: 280 LYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEW--LADTNIEDLREF 337 Query: 328 VK 329 K Sbjct: 338 SK 339 >5YKS-A nrPDB Length = 377 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/258 (28%), Positives = 123/258 (47%), Gaps = 12/258 (4%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LGRG + VV+ RHV +G+ +AVK I T +++ L ++ M+ V P V Y Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVR-CMKLVQHPNIVRLYE 101 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + + +++ +EL D + ++ + + ED+ K IV A+ + H KL V+H Sbjct: 102 VIDTQTKLYLILELGDGG--DMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH-KLHVVH 158 Query: 178 RDVKPSNVL-INALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 RD+KP NV+ G VK+ DFG S T G Y APE + L + + Sbjct: 159 RDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEIL---LGDEYDAP 215 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296 DIWSLG+ + L + P+ + ++ + +P+ S E D ++ L+ Sbjct: 216 AVDIWSLGVILFMLVCGQPPFQEAND--SETLTMIMDCKYTVPS-HVSKECKDLITRMLQ 272 Query: 297 KNSKERPTYPELMQHPFF 314 ++ K R + E+ HP+ Sbjct: 273 RDPKRRASLEEIENHPWL 290 >2F9G-A nrPDB Length = 353 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/305 (27%), Positives = 132/305 (43%), Gaps = 54/305 (17%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI----SMRTVDCPFTVT 114 LG GAYGVV H P+G+I+A+K+I R L ++ I + F + Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQ 78 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + +V+I ELM T L + + Q + +D + ++A++ LH + Sbjct: 79 RPDSFENFNEVYIIQELMQTDLHR-----VISTQMLSDDHIQYFIYQTLRAVKVLHGS-N 132 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-----------AGCKPYMAPE 223 VIHRD+KPSN+LIN+ +K+CDFG++ + +S A + + Y APE Sbjct: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSW-----------GTPFQQLK-Q 269 + L YS D+WS G + EL + R FP + GTP + Sbjct: 193 VM---LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLR 249 Query: 270 VVEEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 314 +E P P PA F +D + L + +R T E ++HP+ Sbjct: 250 CIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 Query: 315 -TLHE 318 T H+ Sbjct: 310 QTYHD 314 >4I6B-A nrPDB Length = 308 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 131/260 (50%), Gaps = 15/260 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM-RTVDCPFTVTFYG 117 LG+G + +M + + ++ A K I + S+ +R +D +I + R + V FY Sbjct: 36 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYH 95 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + +++I +E + ++ + + E + IV L++LH + ++H Sbjct: 96 YFEDKENIYILLEYCSR---RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ-EILH 151 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 RD+K N IN ++K+ DFG++ L ++ +TI G Y++PE LN++G+ Sbjct: 152 RDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTI-CGTPNYLSPE----VLNKQGHG 206 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 +SDIW+LG M + + R P+++ T ++ + + E +P+ A + L Sbjct: 207 AESDIWALGCVMYTMLLGRPPFET--TNLKETYRSIREARYTMPSS-LLAPAKHLIASML 263 Query: 296 KKNSKERPTYPELMQHPFFT 315 KN ++RP+ ++++H FFT Sbjct: 264 SKNPEDRPSLDDIIRHDFFT 283 >4QTB-A nrPDB Length = 380 Score = 90.9 bits (224), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 83/299 (27%), Positives = 134/299 (44%), Gaps = 59/299 (19%) Query: 59 LGRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR----TVDCPFTV 113 +G GAYG+V HV ++ A+K+I + +R L ++ I +R V + Sbjct: 49 IGEGAYGMVSSAYDHVRKTRV-AIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 107 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 L DV+I +LM+T L K K Q + D + I++ L+++HS Sbjct: 108 LRASTLEAMRDVYIVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHSA- 161 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGI----------SGYLVDSVAKTIDAGCKPYMAPE 223 +V+HRD+KPSN+LIN +K+CDFG+ +G+L + VA + Y APE Sbjct: 162 NVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVA------TRWYRAPE 215 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQ---- 277 + LN KGY+ DIWS+G + E+ R FP + + ++ PS + Sbjct: 216 IM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 272 Query: 278 ------------LPAD----------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 LP+ K ++ +D + L N +R T E + HP+ Sbjct: 273 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331 >3OHT-A nrPDB Length = 389 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 132/296 (44%), Gaps = 55/296 (18%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-------QEQKRLLMDLD----ISMRTV 107 +G GAYG V V SG +AVK++ S + RLL + I + V Sbjct: 59 VGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDV 118 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 P T +L DV++ LM L+ I K Q + +D + + I++ L+ Sbjct: 119 FTPAT-----SLEEFNDVYLVTHLMGADLNN-----IVKCQKLTDDHVQFLIYQILRGLK 168 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 ++HS +IHRD+KPSN+ +N ++K+ DFG++ + D + + + Y APE + Sbjct: 169 YIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATRWYRAPEIM-- 223 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPS---------- 275 LN Y++ DIWS+G M EL R FP QQ+ ++ P Sbjct: 224 -LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSH 282 Query: 276 ---------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFFT 315 PQ+P F+ F VD + L ++ +R T E + HP+F+ Sbjct: 283 EARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFS 338 >3IS5-A nrPDB Length = 285 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 139/286 (48%), Gaps = 22/286 (7%) Query: 40 SIGNQN--FEVKADDLEPI-MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 S G +N F+ DDL +LG GA+G V + SG +K I + +++ Sbjct: 8 SSGRENLYFQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQI 67 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID---KGQTIPED 153 ++++ ++++D P + + +++I ME + + ++++ +G+ + E Sbjct: 68 EAEIEV-LKSLDHPNIIKIFEVFEDYHNMYIVMETCEGG--ELLERIVSAQARGKALSEG 124 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAK 210 + ++ ++ AL + HS+ V+H+D+KP N+L +K+ DFG++ Sbjct: 125 YVAELMKQMMNALAYFHSQ-HVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS 183 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ- 269 T AG YMAPE + ++ + K DIWS G+ M L P+ GT ++++Q Sbjct: 184 TNAAGTALYMAPE-----VFKRDVTFKCDIWSAGVVMYFLLTGCLPFT--GTSLEEVQQK 236 Query: 270 -VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 +EP+ + + + VD Q L K+ + RP+ +++ H +F Sbjct: 237 ATYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >3D2K-A nrPDB Length = 272 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 124/266 (46%), Gaps = 19/266 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT----VNSQEQKRLLMDLDISMRTVDCPFTVT 114 LG+G +G V R S I+A+K + T + Q R +++ +R P + Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRH---PNILR 76 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 YG V++ +E L Y++ + K E + AL + HSK Sbjct: 77 LYGYFHDATRVYLILEY--APLGTVYRE-LQKLSRFDEQRTATYITELANALSYCHSK-R 132 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 VIHRD+KP N+L+ + G++K+ DFG S + S +T G Y+ PE I ++ + Sbjct: 133 VIHRDIKPENLLLGSNGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGRMHDE-- 189 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 K D+WSLG+ E + P+++ +Q+ + + P D + D S+ Sbjct: 190 --KVDLWSLGVLCYEFLVGMPPFEA--HTYQETYRRISRVEFTFP-DFVTEGARDLISRL 244 Query: 295 LKKNSKERPTYPELMQHPFFTLHESK 320 LK N+ +R T E+++HP+ + SK Sbjct: 245 LKHNASQRLTLAEVLEHPWIKANSSK 270 >4NEU-A nrPDB Length = 333 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/306 (26%), Positives = 135/306 (44%), Gaps = 31/306 (10%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 ++K+ D EL G +G V H G +M +K + N E L++ M Sbjct: 19 IKMKSSDFLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNCIEHNEALLEEAKMMN 77 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + V G + EG + ME M+ V+ + P + G+I + I++ Sbjct: 78 RLRHSRVVKLLGVIIEEGKYSLVMEYMEKG---NLMHVLKAEMSTPLSVKGRIILEIIEG 134 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL---------------VDSVAK 210 + +LH K VIH+D+KP N+L++ +K+ D G++ + VD AK Sbjct: 135 MCYLHGK-GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 193 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 + G YMAPE +N ++N K + KSD++S + + + + PY++ QQL Sbjct: 194 K-NGGTLYYMAPEHLN-DVNAKP-TEKSDVYSFAVVLWAIFANKEPYEN-AICEQQLIMC 249 Query: 271 VE---EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFF--TLHESKGTD 323 ++ P + E + C + N + RPT+P + + PF+ L ES D Sbjct: 250 IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED 309 Query: 324 VASFVK 329 V S K Sbjct: 310 VKSLKK 315 >4APC-A nrPDB Length = 350 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 135/282 (47%), Gaps = 16/282 (5%) Query: 39 ISIGNQNFEVKA-DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI---RATVNSQEQK 94 + +G +N ++ + + ++G G++G ++ G+ +K I R + +E+ Sbjct: 11 VDLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREES 70 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI 154 R + + +M+ P V + + G ++I M+ + D F + KG ED Sbjct: 71 RREVAVLANMKH---PNIVQYRESFEENGSLYIVMDYCEGG-DLFKRINAQKGVLFQEDQ 126 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA 214 + V I AL+H+H + ++HRD+K N+ + G V++ DFGI+ L +V Sbjct: 127 ILDWFVQICLALKHVHDR-KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARAC 185 Query: 215 GCKPYMAPERINPEL-NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 PY ++PE+ K Y+ KSDIW+LG + EL L+ +++ G+ + +++ Sbjct: 186 IGTPYY----LSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEA-GSMKNLVLKIISG 240 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P + +S + SQ K+N ++RP+ +++ F Sbjct: 241 SFPPVSLH-YSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIA 281 >6GU6-A nrPDB Length = 302 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 107/205 (52%), Gaps = 12/205 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ---KRLLMDLDISMRTV 107 +D I ++G G YGVV K RH +GQ++A+K+IR + S+E+ + ++ + ++ + Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISL-LKEL 63 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 P V+ L ++ +++ E + L K Y I GQ + ++ I++ + Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKK-YLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPERIN 226 HS+ V+HRD+KP N+LI+ G +K+ DFG++ + + T + Y +PE + Sbjct: 123 FCHSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL- 180 Query: 227 PELNQKGYSVKSDIWSLGITMIELA 251 L YS DIWS+G ELA Sbjct: 181 --LGSARYSTPVDIWSIGTIFAELA 203 >6E2O-A nrPDB Length = 295 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/274 (29%), Positives = 132/274 (48%), Gaps = 27/274 (9%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQE-QKRLLMDLDISMRTVDCPFTVTF 115 LG+G YG+V R + + +A+K I R + SQ + + + + + + V + Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNI-----VQY 84 Query: 116 YGALFREGDVWICMEL-----MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 G+ G + I ME + L + + D QTI G I++ L++LH Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI-----GFYTKQILEGLKYLH 139 Query: 171 SKLSVIHRDVKPSNVLINAL-GQVKMCDFGISGYL--VDSVAKTIDAGCKPYMAPERINP 227 ++HRD+K NVLIN G +K+ DFG S L ++ +T G YMAPE I+ Sbjct: 140 DN-QIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETF-TGTLQYMAPEIIDK 197 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-VEEPSPQLPADKFSAE 286 +GY +DIWSLG T+IE+A + P+ G P + +V + + P++P + SAE Sbjct: 198 --GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIP-ESMSAE 254 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 F +C + + +R +L+ F + K Sbjct: 255 AKAFILKCFEPDPDKRACANDLLVDEFLKVSSKK 288 >1G3N-A nrPDB Length = 326 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/296 (27%), Positives = 135/296 (45%), Gaps = 44/296 (14%) Query: 54 EPIMELGRGAYGVVEKMRHVPSG-QIMAVKRIRATVNSQEQKRLLMDLDIS----MRTVD 108 E + E+G GAYG V K R + +G + +A+KR+R +E L +++ + T + Sbjct: 14 ECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQ-TGEEGMPLSTIREVAVLRHLETFE 72 Query: 109 CPFTVTFYGALF-----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 P V + RE + + E +D L + +V + G +P + + + ++ Sbjct: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQLL 130 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 + L+ LHS V+HRD+KP N+L+ + GQ+K+ DFG++ +A T Y APE Sbjct: 131 RGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPE 189 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV-------EEPSP 276 L Q Y+ D+WS+G E+ R P + QL +++ EE P Sbjct: 190 ----VLLQSSYATPVDLWSVGCIFAEM-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244 Query: 277 Q---LPADKFSA-------EFV--------DFTSQCLKKNSKERPTYPELMQHPFF 314 + LP F + +FV D +CL N +R + + HP+F Sbjct: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 >4MVF-A nrPDB Length = 506 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 76/263 (28%), Positives = 124/263 (47%), Gaps = 17/263 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +LG+G YG V K + Q+ A+K + + R +++I M+ +D P V Y Sbjct: 64 KLGQGTYGCVYKGIDKVTNQLYAIKEEKKD-RLKNINRFFQEIEI-MKKLDHPNIVKLYE 121 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + +++ MEL S + + +I+ G + E I I A+ +LHS L+++H Sbjct: 122 TYENDNYIYLIMEL--CSGRELFDSIIENG-SFTEKNAATIMKQIFSAIFYLHS-LNIVH 177 Query: 178 RDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 RD+KP N L N +K+ DFG+S L T AG Y+AP+ ++ + Y Sbjct: 178 RDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDGK-----Y 232 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD--KFSAEFVDFTS 292 K DIWS G+ M L + +P T + LK+V + D S++ + + Sbjct: 233 DKKCDIWSSGVIMYTL-LCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLIT 291 Query: 293 QCLKKNSKERPTYPELMQHPFFT 315 + L N ER T E + HP+ T Sbjct: 292 KLLTYNPNERCTIEEALNHPWIT 314 >4Y93-A nrPDB Length = 446 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 78/283 (27%), Positives = 139/283 (49%), Gaps = 34/283 (12%) Query: 41 IGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQ----EQKR 95 +G ++E+ DL + ELG G +GVV+ + GQ +A+K I+ S+ E+ + Sbjct: 178 LGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW--RGQYDVAIKMIKEGSMSEDEFIEEAK 235 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDI 154 ++M+L V YG ++ ++I E M + L + +++ + QT Sbjct: 236 VMMNLSHEK-------LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT---QQ 285 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA 214 L ++ + +A+E+L SK +HRD+ N L+N G VK+ DFG++ Y++D T Sbjct: 286 LLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDD-EYTSST 343 Query: 215 GCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTP--FQQLK 268 G K + +PE L +S KSDIW+ G+ M E+ L + PY+ + + + Sbjct: 344 GSKFPVKWASPEV----LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 399 Query: 269 QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 Q + P P L +++ A C + + ERPT+ L+ + Sbjct: 400 QGLRLPRPHLASERVYA----IMYSCWHEKADERPTFKILLSN 438 >1FOT-A nrPDB Length = 318 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 108/210 (51%), Gaps = 12/210 (5%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLMDLDISMRTVDCP 110 D + + LG G++G V +R +G+ A+K ++ + + +Q D + + V P Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHP 66 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 F + +G +++ M+ ++ + F ++ K Q P + A + ALE+LH Sbjct: 67 FIIRMWGTFQDAQQIFMIMDYIEGG-ELF--SLLRKSQRFPNPVAKFYAAEVCLALEYLH 123 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 SK +I+RD+KP N+L++ G +K+ DFG + Y+ D V T+ G Y+APE + + Sbjct: 124 SK-DIIYRDLKPENILLDKNGHIKITDFGFAKYVPD-VTYTL-CGTPDYIAPEVV----S 176 Query: 231 QKGYSVKSDIWSLGITMIELAILRFP-YDS 259 K Y+ D WS GI + E+ P YDS Sbjct: 177 TKPYNKSIDWWSFGILIYEMLAGYTPFYDS 206 >5O2C-A nrPDB Length = 380 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 67/265 (25%), Positives = 124/265 (46%), Gaps = 17/265 (6%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +ELGRGA+ V K + +A ++ + EQ+R + ++ ++ + P V F Sbjct: 31 IELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM-LKGLQHPNIVRF 89 Query: 116 YGA----LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 Y + L + + + ELM + K Y + + + + +L I+K L+ LH+ Sbjct: 90 YDSWESILKGKKCIVLVTELMTSGTLKTY---LKRFKVMKPKVLRSWCRQILKGLQFLHT 146 Query: 172 KLS-VIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 + +IHRD+K N+ I G VK+ D G++ + S AK++ PE + PE+ Sbjct: 147 RTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIG------TPEFMAPEM 200 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 ++ Y D+++ G+ M+E+A +PY Q ++V P E + Sbjct: 201 YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKE 260 Query: 290 FTSQCLKKNSKERPTYPELMQHPFF 314 C+++N ER + +L+ H FF Sbjct: 261 IIEGCIRQNKSERLSIRDLLNHAFF 285 >4ZSG-A nrPDB Length = 347 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 76/250 (30%), Positives = 125/250 (50%), Gaps = 32/250 (12%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-QEQKRLLMDLDI- 102 F+V D+ E I +G GAYGVV R +GQ +A+K+I + KR L +L I Sbjct: 2 TFDV-GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 60 Query: 103 ---------SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPED 153 +++ + P TV YG V++ ++LM++ L Q+I Q + + Sbjct: 61 KHFKHDNIIAIKDILRP-TVP-YGEF---KSVYVVLDLMESDL----HQIIHSSQPLTLE 111 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK--- 210 + +++ L+++HS VIHRD+KPSN+L+N ++K+ DFG++ L S A+ Sbjct: 112 HVRYFLYQLLRGLKYMHSA-QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQY 170 Query: 211 --TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQ 266 T + Y APE + L+ Y+ D+WS+G E+ R FP ++ Q Sbjct: 171 FMTEYVATRWYRAPELM---LSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL 227 Query: 267 LKQVVEEPSP 276 + V+ PSP Sbjct: 228 IMMVLGTPSP 237 >5O2B-A nrPDB Length = 285 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/265 (25%), Positives = 124/265 (46%), Gaps = 17/265 (6%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +ELGRGA+ V K + +A ++ + EQ+R + ++ ++ + P V F Sbjct: 22 IELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM-LKGLQHPNIVRF 80 Query: 116 YGA----LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 Y + L + + + ELM + K Y + + + + +L I+K L+ LH+ Sbjct: 81 YDSWESILKGKKCIVLVTELMTSGTLKTY---LKRFKVMKPKVLRSWCRQILKGLQFLHT 137 Query: 172 KLS-VIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 + +IHRD+K N+ I G VK+ D G++ + S AK++ PE + PE+ Sbjct: 138 RTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIG------TPEFMAPEM 191 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 ++ Y D+++ G+ M+E+A +PY Q ++V P E + Sbjct: 192 YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKE 251 Query: 290 FTSQCLKKNSKERPTYPELMQHPFF 314 C+++N ER + +L+ H FF Sbjct: 252 IIEGCIRQNKSERLSIRDLLNHAFF 276 >4IC8-A nrPDB Length = 442 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 76/252 (30%), Positives = 126/252 (50%), Gaps = 32/252 (12%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-QEQKRLLMDLDI- 102 F+V D+ E I +G GAYGVV R +GQ +A+K+I + KR L +L I Sbjct: 50 TFDV-GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 108 Query: 103 ---------SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPED 153 +++ + P TV YG V++ ++LM++ L Q+I Q + + Sbjct: 109 KHFKHDNIIAIKDILRP-TVP-YGEF---KSVYVVLDLMESDL----HQIIHSSQPLTLE 159 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK--- 210 + +++ L+++HS VIHRD+KPSN+L+N ++K+ DFG++ L S A+ Sbjct: 160 HVRYFLYQLLRGLKYMHSA-QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQY 218 Query: 211 --TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQ 266 T + Y APE + L+ Y+ D+WS+G E+ R FP ++ Q Sbjct: 219 FMTEYVATRWYRAPELM---LSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL 275 Query: 267 LKQVVEEPSPQL 278 + V+ PSP + Sbjct: 276 IMMVLGTPSPAV 287 >5DYK-A nrPDB Length = 853 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 66/219 (30%), Positives = 111/219 (50%), Gaps = 19/219 (8%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLD 101 Q+ +V+ D+LE +GRG +G V+ + H P+ A+K + R+ +N +Q + ++ + Sbjct: 532 QDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLERE 591 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG---QTIPEDILGKI 158 I+ D PF + + EL+ + Y + G ++ + LG Sbjct: 592 ITAEN-DHPFIIRLVRTFKDSKYFYFLTELVTGG--ELYDAIRKLGLLSKSQAQFYLG-- 646 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 SI+ A+E+LH + ++++RD+KP N+L++ G VK+ DFG + V A T+ G Sbjct: 647 --SIILAIEYLHER-NIVYRDLKPENILLDKQGYVKLIDFGCAKK-VQGRAYTL-VGTPH 701 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 YMAPE I KGY DIW+LGI + E P+ Sbjct: 702 YMAPEVILG----KGYGCTVDIWALGICLYEFICGPLPF 736 >4AU8-A nrPDB Length = 296 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 127/295 (43%), Gaps = 45/295 (15%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-----ATVNSQEQKRLLMDLDISMRTVD 108 E + ++G G YG V K ++ + +I+A+KR+R V S + + + ++ + + Sbjct: 9 EKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI- 67 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V + L + + + E D L K++ G PE I+ ++K L Sbjct: 68 ----VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPE-IVKSFLFQLLKGLGF 120 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPERINP 227 HS+ +V+HRD+KP N+LIN G++K+ DFG++ + + + + Y P+ + Sbjct: 121 CHSR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL-- 177 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--------------- 272 K YS D+WS G ELA P QLK++ Sbjct: 178 -FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK 236 Query: 273 ----EPSPQLPAD--------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +P P PA K +A D LK N +R + E +QHP+F+ Sbjct: 237 LPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 291 >3ZDU-A nrPDB Length = 325 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 83/311 (26%), Positives = 133/311 (42%), Gaps = 77/311 (24%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVK----RIRATVNSQEQKRLLMDLDISMRTVDC 109 E + ++G G+YG V K +H +GQI+A+K R +VN I+MR + Sbjct: 6 ETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNK-----------IAMREIK- 53 Query: 110 PFTVTFYGA-------LFREGD-VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAV 160 F F+ +FR+ + + E +D T LD+ + L K Sbjct: 54 -FLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYC----HGLESKRLRKYLF 108 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-------DSVAKTID 213 I++A+++LHS ++IHRD+KP N+L++ G K+CDFG + L D VA Sbjct: 109 QILRAIDYLHSN-NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVA---- 163 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 + Y APE + L Y DIW+LG +IE+A PY + L ++V + Sbjct: 164 --TRWYRAPELV---LKDTSYGKPVDIWALGCMIIEMATGN-PYLPSSSDLDLLHKIVLK 217 Query: 274 -----------------------PSPQLPAD------KFSAEFVDFTSQCLKKNSKERPT 304 P Q P + K + D CL+ + +R + Sbjct: 218 VGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRIS 277 Query: 305 YPELMQHPFFT 315 +L+ H +FT Sbjct: 278 SSDLLHHEYFT 288 >5X5O-A nrPDB Length = 310 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 125/272 (45%), Gaps = 23/272 (8%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 G ++K DDL+ G G++G V + + + + +AVK++ E +L + Sbjct: 6 GASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRN 65 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQV-IDKGQTIPEDILGKIAV 160 I + FYG + + I E SL Y + ++ + + D + A Sbjct: 66 I----------IQFYGVILEPPNYGIVTEY--ASLGSLYDYINSNRSEEMDMDHIMTWAT 113 Query: 161 SIVKALEHLH--SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 + K + +LH + + VIHRD+K NV+I A G +K+CDFG S + + ++ G P Sbjct: 114 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFP 172 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 +MAPE I S D +S G+ + E+ P+ G Q+ +V E + +L Sbjct: 173 WMAPEVI----QSLPVSETCDTYSYGVVLWEMLTREVPFK--GLEGLQVAWLVVEKNERL 226 Query: 279 PA-DKFSAEFVDFTSQCLKKNSKERPTYPELM 309 F + QC + ++K+RP++ +++ Sbjct: 227 TIPSSCPRSFAELLHQCWEADAKKRPSFKQII 258 >4QNY-A nrPDB Length = 354 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 83/317 (26%), Positives = 138/317 (43%), Gaps = 68/317 (21%) Query: 59 LGRGAYGVVEKMRHVPS-GQIMAVKRIRATVNSQE--QKRLLMDLD----------ISMR 105 +G G+YGVV + R S +++A+KR+ + + KR+L ++ I +R Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P + + I M++M+T L KQV+ GQ + E + ++A Sbjct: 88 NILTPEDPENFDHFY------IVMDIMETDL----KQVLRSGQELTEAHIQFFIYQALRA 137 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-------YLVDSVAKTIDAGCKP 218 L +HS VIHRD+ P+N+L+N +K+CDFG++ Y+ D V + Sbjct: 138 LHIIHSA-GVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVT------MRW 190 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-------------DSWGTPFQ 265 Y APE + + K YS + D+W +G + EL R + D GTP + Sbjct: 191 YRAPELV---MEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSE 247 Query: 266 Q---------LKQVVEEPSPQLPAD------KFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + ++ +++ S + AD S E +D L N K R T + M+ Sbjct: 248 EDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMR 307 Query: 311 HPFFTLHESKGTDVASF 327 HPF D S+ Sbjct: 308 HPFLEQLHDDADDNLSY 324 >3C51-A nrPDB Length = 543 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 79/275 (28%), Positives = 130/275 (47%), Gaps = 34/275 (12%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATV--------NSQEQKRLLMDLDISMRTVDCP 110 LGRG +G V + +G++ A K++ + +K++L V Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILA-------KVHSR 245 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK---GQTIPEDILGKIAVSIVKALE 167 F V+ A + D+ + M +M+ +++ +D+ G P I IV LE Sbjct: 246 FIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIF--YTAQIVSGLE 303 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERIN 226 HLH + ++I+RD+KP NVL++ G V++ D G++ L KT AG +MAPE + Sbjct: 304 HLHQR-NIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLL 362 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ--QLKQVVEEPSPQLPADKFS 284 E Y D ++LG+T+ E+ R P+ + G + +LKQ V E + P DKFS Sbjct: 363 GE----EYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYP-DKFS 417 Query: 285 AEFVDFTSQCLKKNSKERPTYPE-----LMQHPFF 314 DF L+K+ ++R + + L HP F Sbjct: 418 PASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLF 452 >6E4F-A nrPDB Length = 290 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 80/291 (27%), Positives = 140/291 (48%), Gaps = 32/291 (10%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNS 90 +L + +G ++E+ DL + ELG G +GVV+ + GQ +A+K I+ S Sbjct: 12 NLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW--RGQYDVAIKMIKEGSMS 69 Query: 91 Q----EQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVID 145 + E+ +++M+L V YG ++ ++I E M + L + +++ Sbjct: 70 EDEFIEEAKVMMNLSHEK-------LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH 122 Query: 146 KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV 205 + QT L ++ + +A+E+L SK +HRD+ N L+N G VK+ DFG+S Y++ Sbjct: 123 RFQT---QQLLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVL 178 Query: 206 DSVAKTIDAGCKPYMAPERINPE--LNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGT 262 D T G K P R +P L +S KSDIW+ G+ M E+ L + PY+ + Sbjct: 179 DD-EYTSSVGSK---FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTN 234 Query: 263 P--FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + + Q + P L ++K C + + ERPT+ L+ + Sbjct: 235 SETAEHIAQGLRLYRPHLASEKVYT----IMYSCWHEKADERPTFKILLSN 281 >5WAX-A nrPDB Length = 310 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 73/273 (26%), Positives = 126/273 (46%), Gaps = 21/273 (7%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISMRTV 107 D E + ++G G +GV MR+ GQ++AVK I ++ Q+ + I+ R++ Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREI-----INHRSL 64 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 P + F + + I ME S + ++++ + G+ ED ++ + Sbjct: 65 RHPNIIRFKEVILTPTHLAIVMEY--ASGGELFERICNAGR-FSEDEARFFFQQLISGVS 121 Query: 168 HLHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 + HS + V HRD+K N L++ ++K+CDFG S V G Y+APE Sbjct: 122 YCHS-MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPE-- 178 Query: 226 NPELNQKGYSVK-SDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLP-AD 281 L +K Y K +D+WS G+T+ + + +P++ P F++ Q + +P Sbjct: 179 --VLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYV 236 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E D S+ N R T PE+ HP+F Sbjct: 237 HISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >5VO2-A nrPDB Length = 300 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 81/274 (29%), Positives = 120/274 (43%), Gaps = 36/274 (13%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SM 104 +EV +++ + +G GA G V R G+ +AVK++R L + DI + Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGRF--HGEEVAVKKVRD----------LKETDIKHL 54 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 R + P +TF G + I ME + + Y +V+ G+ + +L ++ I Sbjct: 55 RKLKHPNIITFKGVCTQAPCYCILMEF--CAQGQLY-EVLRAGRPVTPSLLVDWSMGIAG 111 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 + +LH +IHRD+K N+LI VK+ DFG S L D K AG +MAPE Sbjct: 112 GMNYLHLH-KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 170 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPY---DS----WGTPFQQLKQVVEEPSPQ 277 I E S K DIWS G+ + EL PY DS WG L P P Sbjct: 171 IRNE----PVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL----PVPS 222 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 D F QC + RP++ +++ H Sbjct: 223 SCPDGFKI----LLRQCWNSKPRNRPSFRQILLH 252 >5NGU-A nrPDB Length = 381 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 113/233 (48%), Gaps = 31/233 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR----TVDCPFTVT 114 +G GAYG+V + +A+K+I + +R L ++ I +R + + Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDII 109 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + + DV+I +LM+T L K K Q + D + I++ L+++HS + Sbjct: 110 RAPTIEQMKDVYIVQDLMETDLYKLLKT-----QHLSNDHICYFLYQILRGLKYIHSA-N 163 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGI----------SGYLVDSVAKTIDAGCKPYMAPER 224 V+HRD+KPSN+L+N +K+CDFG+ +G+L + VA + Y APE Sbjct: 164 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVA------TRWYRAPEI 217 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPS 275 + LN KGY+ DIWS+G + E+ R FP + + ++ PS Sbjct: 218 M---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 267 >4XI2-A nrPDB Length = 446 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 140/289 (48%), Gaps = 32/289 (11%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQ- 91 ++ + +G ++E+ DL + ELG G +GVV+ + GQ +A+K IR S+ Sbjct: 170 NAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW--RGQYDVAIKMIREGSMSED 227 Query: 92 ---EQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKG 147 E+ +++M+L V YG ++ ++I E M + L + +++ + Sbjct: 228 EFIEEAKVMMNLSHEK-------LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF 280 Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS 207 QT L ++ + +A+E+L SK +HRD+ N L+N G VK+ DFG+S Y++D Sbjct: 281 QT---QQLLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD 336 Query: 208 VAKTIDAGCKPYMAPERINPE--LNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTP- 263 T G K P R +P L +S KSDIW+ G+ M E+ L + PY+ + Sbjct: 337 -EYTSSVGSK---FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSE 392 Query: 264 -FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + + Q + P L +++ C + + ERP++ L+ + Sbjct: 393 TAEHIAQGLRLYRPHLASERVYT----IMYSCWHEKADERPSFKILLSN 437 >5KZ7-A nrPDB Length = 346 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 66/253 (26%), Positives = 124/253 (49%), Gaps = 12/253 (4%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +G+G + V+ RH+ +G+ +AVK I T +NS ++L ++ I M+ ++ P V + Sbjct: 41 IGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI-MKVLNHPNIVKLFE 99 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + E +++ ME S + + ++ G+ ++ K IV A+++ H K ++H Sbjct: 100 VIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFR-QIVSAVQYCHQKF-IVH 155 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVK 237 RD+K N+L++A +K+ DFG S G PY APE +K + Sbjct: 156 RDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQ---GKKYDGPE 212 Query: 238 SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKK 297 D+WSLG+ + L P+D G ++L++ V ++P S + + + L Sbjct: 213 VDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPF-YMSTDCENLLKKFLIL 269 Query: 298 NSKERPTYPELMQ 310 N +R T ++M+ Sbjct: 270 NPSKRGTLEQIMK 282 >4L42-A nrPDB Length = 346 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 77/280 (27%), Positives = 130/280 (46%), Gaps = 24/280 (8%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVP---SGQIMAVKRIRATV---NSQEQKRLLMDL 100 +++ + E + LG+G YG V ++R V +G+I A+K ++ + N+++ + Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 73 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +I + V PF V A G +++ +E + S + + Q+ +G ED Sbjct: 74 NI-LEEVKHPFIVDLIYAFQTGGKLYLILEYL--SGGELFMQLEREG-IFMEDTACFYLA 129 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPY 219 I AL HLH K +I+RD+KP N+++N G VK+ DFG+ + D G Y Sbjct: 130 EISMALGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 MAPE L + G++ D WSLG M ++ P+ G ++ + + LP Sbjct: 189 MAPEI----LMRSGHNRAVDWWSLGALMYDMLTGAPPFT--GENRKKTIDKILKCKLNLP 242 Query: 280 ADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 + E D + LK+N+ R E+ HPFF Sbjct: 243 P-YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 >1VZO-A nrPDB Length = 355 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 79/290 (27%), Positives = 136/290 (46%), Gaps = 31/290 (10%) Query: 41 IGNQNFEVKADDLEPIMELGRGAYG---VVEKMRHVPSGQIMAVKRIRATVNSQEQK--- 94 +G +NFE+ + LG GAYG +V K+ +G++ A+K ++ Q+ K Sbjct: 51 VGIENFEL-------LKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTE 103 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI 154 + + PF VT + A E + + ++ ++ + + + + + ++ Sbjct: 104 HTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG--ELFTHLSQRERFTEHEV 161 Query: 155 LGKIAVS-IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKTI 212 +I V IV ALEHLH KL +I+RD+K N+L+++ G V + DFG+S ++ D + Sbjct: 162 --QIYVGEIVLALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAY 218 Query: 213 D-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ--LKQ 269 D G YMAP+ + G+ D WSLG+ M EL P+ G Q + + Sbjct: 219 DFCGTIEYMAPDIVRG--GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISR 276 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 + + P P + SA D + L K+ K+R E+ +H FF Sbjct: 277 RILKSEPPYPQE-MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF 325 >3NIZ-A nrPDB Length = 311 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 77/301 (25%), Positives = 136/301 (45%), Gaps = 38/301 (12%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 N F+ + + + ++G G YGVV K + G+I+A+KRIR + + Sbjct: 13 NLYFQGLMEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREIS 71 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV-S 161 ++ + P V+ + E C+ L+ ++K K+V+D+ +T +D KI + Sbjct: 72 LLKELHHPNIVSLIDVIHSER----CLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQ 127 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYM 220 +++ + H H ++HRD+KP N+LIN+ G +K+ DFG++ + + + T + Y Sbjct: 128 LLRGVAHCHQH-RILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYR 186 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILR--FP-----------YDSWGTPF--- 264 AP+ + + K YS DIWS+G E+ + FP + GTP Sbjct: 187 APDVL---MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPRE 243 Query: 265 -----------QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 Q+ QV E+ F E +D S L + +R + + M HP+ Sbjct: 244 WPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPY 303 Query: 314 F 314 F Sbjct: 304 F 304 >4RLP-A nrPDB Length = 288 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/280 (27%), Positives = 130/280 (46%), Gaps = 24/280 (8%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVP---SGQIMAVKRIRATV---NSQEQKRLLMDL 100 +++ + E + LG+G YG V ++R V +G+I A+K ++ + N+++ + Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +I + V PF V A G +++ +E + S + + Q+ +G ED Sbjct: 61 NI-LEEVKHPFIVDLIYAFQTGGKLYLILEYL--SGGELFMQLEREG-IFMEDTACFYLA 116 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPY 219 I AL HLH K +I+RD+KP N+++N G VK+ DFG+ + D G Y Sbjct: 117 EISMALGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 MAPE L + G++ D WSLG M ++ P+ G ++ + + LP Sbjct: 176 MAPEI----LMRSGHNRAVDWWSLGALMYDMLTGAPPFT--GENRKKTIDKILKCKLNLP 229 Query: 280 ADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 + E D + LK+N+ R E+ HPFF Sbjct: 230 P-YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 >2J0K-A nrPDB Length = 656 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 129/292 (44%), Gaps = 35/292 (11%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHV-PSGQIMAV--KRIRATVNSQEQKRLLMDL 100 +++E++ + +E +G G +G V + ++ P MAV K + + +++ L + Sbjct: 383 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEA 442 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 ++MR D P V G + E VWI MEL + + QV + IL A Sbjct: 443 -LTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKFSLDLASLIL--YAY 498 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP-- 218 + AL +L SK +HRD+ NVL++A VK+ DFG+S Y+ DS G P Sbjct: 499 QLSTALAYLESK-RFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIK 557 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ-----VVEE 273 +MAPE I N + ++ SD+W G+ M E+ + PFQ +K +E Sbjct: 558 WMAPESI----NFRRFTSASDVWMFGVCMWEILMHGV------KPFQGVKNNDVIGRIEN 607 Query: 274 PS-----PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 P P +S ++C + RP + EL L E K Sbjct: 608 GERLPMPPNCPPTLYS-----LMTKCWAYDPSRRPRFTELKAQLSTILEEEK 654 >1PHK-A nrPDB Length = 298 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 127/277 (45%), Gaps = 19/277 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT----VNSQEQKRL----LMDLDI 102 ++ EP LGRG VV + H P+ + AVK I T +++E + L L ++DI Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + P + ++ +LM + + + +K T+ E KI ++ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKG--ELFDYLTEK-VTLSEKETRKIMRAL 133 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 ++ + LH KL+++HRD+KP N+L++ +K+ DFG S L G Y+AP Sbjct: 134 LEVICALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAP 192 Query: 223 ERINPELNQK--GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 E I +N GY + D+WS G+ M L P+ W + +++ + Q + Sbjct: 193 EIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPF--WHRKQMLMLRMIMSGNYQFGS 250 Query: 281 ---DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 D +S D S+ L ++R T E + HPFF Sbjct: 251 PEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFF 287 >6ED6-A nrPDB Length = 415 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 71/283 (25%), Positives = 128/283 (45%), Gaps = 23/283 (8%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLD 101 + ++KA+D + + +GRGA+G V+ +RH S ++ A+K + + + + D Sbjct: 81 RGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERD 140 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID--KGQTIPEDILGKIA 159 I M + P+ V + A + +++ ME M +++ +PE Sbjct: 141 I-MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG------DLVNLMSNYDVPEKWAKFYT 193 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCK 217 +V AL+ +HS + +IHRDVKP N+L++ G +K+ DFG + ++ D G Sbjct: 194 AEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 252 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 Y++PE + + Y + D WS+G+ + E+ + P+ + K + + S Sbjct: 253 DYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC 312 Query: 278 LPADKFSAEFVDFTSQ--CLKKNSKE----RPTYPELMQHPFF 314 P D AE C +E R E+ QHPFF Sbjct: 313 FPED---AEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFF 352 >4CSV-A nrPDB Length = 275 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/272 (26%), Positives = 128/272 (47%), Gaps = 22/272 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ ++ +LG G +G V + + +AVK ++ S E+ L + I M+ Sbjct: 6 WEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE--FLQEAQI-MK 62 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + P V YG +E ++I E M SL + + +G T+ L +A + Sbjct: 63 KLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDC--EGHTVNAQALLDMAAQVAS 120 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYMA 221 + +L S+ + IHRD+ N L+ VK+ DFG++ L++ T AG K + A Sbjct: 121 GMAYLESQ-NFIHRDLAARNCLVGENNVVKVADFGLA-RLINEDEYTARAGAKFPIKWTA 178 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIEL---AILRFPYDSWGTPFQQLKQVVEEPSPQL 278 PE I + +S+KSD+W+ GI + E+ + +P S +Q+++ P PQ Sbjct: 179 PEAI----SYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQG 234 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + E + QC K+ +ERPT+ E + Sbjct: 235 CPE----EIYELMLQCWNKSPEERPTFAETLH 262 >4WNO-A nrPDB Length = 287 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 82/282 (29%), Positives = 130/282 (46%), Gaps = 30/282 (10%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISM 104 FE DL +G GA+ VV K RH + + +AVK I ++ Q L ++ I + Sbjct: 18 FEFSRKDL-----IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKI-L 71 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + V Y V++ ME + Y + +T+ ED + I Sbjct: 72 KELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM---RTLSEDTIRLFLQQIAG 128 Query: 165 ALEHLHSKLSVIHRDVKPSNVLI-NALGQ--------VKMCDFGISGYLVDSVAKTIDAG 215 A+ LHSK +IHRD+KP N+L+ N G+ VK+ DFG + YL ++ G Sbjct: 129 AMRLLHSK-GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCG 187 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 YMAPE I ++Q Y K+D+WS+G + + + P+ + +P Q L+ E+ Sbjct: 188 SPMYMAPEVI---MSQH-YDGKADLWSIGTIVYQCLTGKAPFQA-SSP-QDLRLFYEKNK 241 Query: 276 ---PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 P +P + SA L++N K+R + E HPF Sbjct: 242 TLVPTIPRET-SAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >5ES1-A nrPDB Length = 328 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 65/259 (25%), Positives = 124/259 (47%), Gaps = 12/259 (4%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +G+G + V+ RH+ +G+ +A+K I T +N ++L ++ I M+ ++ P V + Sbjct: 23 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRI-MKGLNHPNIVKLFE 81 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + E +++ ME S + + ++ G+ ++ K IV A+ + H K +++H Sbjct: 82 VIETEKTLYLVMEY--ASAGEVFDYLVSHGRMKEKEARAKFR-QIVSAVHYCHQK-NIVH 137 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVK 237 RD+K N+L++A +K+ DFG S G PY APE +K + Sbjct: 138 RDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQ---GKKYDGPE 194 Query: 238 SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKK 297 DIWSLG+ + L P+D G ++L++ V ++P S + + L Sbjct: 195 VDIWSLGVILYTLVSGSLPFD--GHNLKELRERVLRGKYRVPF-YMSTDCESILRRFLVL 251 Query: 298 NSKERPTYPELMQHPFFTL 316 N +R T ++M+ + + Sbjct: 252 NPAKRCTLEQIMKDKWINI 270 >4EBW-A nrPDB Length = 304 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 131/300 (43%), Gaps = 25/300 (8%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEK---MRHVPSGQIMAVKRIRATV 88 +L + + +++E++ + +E +G G +G V + M +A+K + Sbjct: 19 NLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT 78 Query: 89 NSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQ 148 + +++ L + ++MR D P V G + E VWI MEL + + QV Sbjct: 79 SDSVREKFLQE-ALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFLQVRKYSL 136 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + IL A + AL +L SK +HRD+ NVL+++ VK+ DFG+S Y+ DS Sbjct: 137 DLASLIL--YAYQLSTALAYLESK-RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST 193 Query: 209 AKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ 266 G P +MAPE I N + ++ SD+W G+ M E+ + PFQ Sbjct: 194 YYKASKGKLPIKWMAPESI----NFRRFTSASDVWMFGVCMWEILMHGV------KPFQG 243 Query: 267 LKQ--VVE--EPSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 +K V+ E +LP ++C + RP + EL L E K Sbjct: 244 VKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKA 303 >3HDN-A nrPDB Length = 373 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 136/286 (47%), Gaps = 19/286 (6%) Query: 39 ISIG-NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKR 95 I++G + N K D + +G+G++G V RH AVK + +A + +E+K Sbjct: 25 INLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKH 84 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 ++ + ++ ++ V PF V + + ++ ++ ++ + FY + + + E Sbjct: 85 IMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG-ELFYH--LQRERCFLEPRA 141 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-A 214 A I AL +LHS L++++RD+KP N+L+++ G + + DFG+ ++ + T Sbjct: 142 RFYAAEIASALGYLHS-LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFC 200 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G Y+APE L+++ Y D W LG + E+ P+ S T + ++ +P Sbjct: 201 GTPEYLAPEV----LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTA-EMYDNILNKP 255 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKER----PTYPELMQHPFFTL 316 P SA + L+K+ +R + E+ H FF+L Sbjct: 256 LQLKPNITNSARHL--LEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 299 >3A8W-A nrPDB Length = 345 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 131/280 (46%), Gaps = 27/280 (9%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQ-KRLLMDLDISMRTVDC 109 D + + +GRG+Y V +R + +I A+K ++ VN E + + + + + Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNH 69 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 PF V + E ++ +E ++ F+ Q + + +PE+ + I AL +L Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ---RQRKLPEEHARFYSAEISLALNYL 126 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSVAKTIDAGCKPYMAPERINP 227 H + +I+RD+K NVL+++ G +K+ D+G+ G T G Y+APE + Sbjct: 127 HER-GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTF-CGTPNYIAPEILRG 184 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT---PFQQ----LKQVVEEPSPQLPA 280 E G+SV D W+LG+ M E+ R P+D G+ P Q L QV+ E ++P Sbjct: 185 E--DYGFSV--DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 240 Query: 281 DKFSAEFVDFTSQCLKKNSKER------PTYPELMQHPFF 314 S + L K+ KER + ++ HPFF Sbjct: 241 -SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF 279 >4BGQ-A nrPDB Length = 304 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 99/195 (50%), Gaps = 10/195 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G GAYGVV K RH + +I+A+K+ + + ++E K + +RT+ V A Sbjct: 20 VGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEA 79 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 R G +++ E ++ ++ + +++ + +P + + ++KA+ H K ++HR Sbjct: 80 FRRRGKLYLVFEYVEKNMLELLEEMPN---GVPPEKVKSYIYQLIKAIHWCH-KNDIVHR 135 Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCKPYMAPERINPELNQKGYSV 236 D+KP N+LI+ +K+CDFG + L + D + Y +PE L Y Sbjct: 136 DIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPEL----LLGAPYGK 191 Query: 237 KSDIWSLGITMIELA 251 D+WS+G + EL+ Sbjct: 192 SVDMWSVGCILGELS 206 >4M7I-A nrPDB Length = 299 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 77/289 (26%), Positives = 133/289 (46%), Gaps = 37/289 (12%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 D EPI LGRG +GVV + ++ A+KRIR +++++ ++ ++ ++ P Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVK-ALAKLEHPG 64 Query: 112 TVTFYGALFREG----------DVWICMELMDTSLDKFYKQVIDKGQTIPE---DILGKI 158 V ++ A + V++ ++ M + K ++ TI E + I Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQ-MQLCRKENLKDWMNGRCTIEERERSVCLHI 123 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG-ISGYLVDSVAKTI----- 212 + I +A+E LHSK ++HRD+KPSN+ VK+ DFG ++ D +T+ Sbjct: 124 FLQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 213 -------DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 G K YM+PE+I + YS K DI+SLG+ + EL +P+ + + Sbjct: 183 AYARHTGQVGTKLYMSPEQI----HGNSYSHKVDIFSLGLILFELL---YPFSTQMERVR 235 Query: 266 QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 L V P L K+ E+V L + ERP ++++ F Sbjct: 236 TLTDVRNLKFPPLFTQKYPCEYV-MVQDMLSPSPMERPEAINIIENAVF 283 >3H4J-B nrPDB Length = 336 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 66/262 (25%), Positives = 125/262 (47%), Gaps = 16/262 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 117 LG G++G V+ H + Q +A+K I + + + ++ +IS ++ + P + Y Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + D+ + +E L + +++K + + ED + I+ A+E+ H + ++H Sbjct: 77 VITTPTDIVMVIEYAGGEL---FDYIVEK-KRMTEDEGRRFFQQIICAIEYCH-RHKIVH 131 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVK 237 RD+KP N+L++ VK+ DFG+S + D G Y APE IN +L G V Sbjct: 132 RDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKL-YAGPEV- 189 Query: 238 SDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 D+WS GI + + + R P+D P F+++ V + D S + + Sbjct: 190 -DVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCV-----YVMPDFLSPGAQSLIRRMI 243 Query: 296 KKNSKERPTYPELMQHPFFTLH 317 + +R T E+ + P+F ++ Sbjct: 244 VADPMQRITIQEIRRDPWFNVN 265 >6C9D-A nrPDB Length = 459 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 113/224 (50%), Gaps = 15/224 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +G+G + V+ RHV +G+ +AVK I T +N ++L ++ I M+ ++ P V + Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRI-MKILNHPNIVKLFE 87 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + E +++ ME S + + ++ G+ ++ K IV A+++ H K ++H Sbjct: 88 VIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFR-QIVSAVQYCHQKY-IVH 143 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--PYMAPERINPELNQKGYS 235 RD+K N+L++ +K+ DFG S +V +D C PY APE +K Sbjct: 144 RDLKAENLLLDGDMNIKIADFGFSNEF--TVGNKLDEFCGSPPYAAPELFQ---GKKYDG 198 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 + D+WSLG+ + L P+D G ++L++ V ++P Sbjct: 199 PEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIP 240 >5KCV-A nrPDB Length = 460 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 71/285 (24%), Positives = 131/285 (45%), Gaps = 19/285 (6%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-NSQEQKRLL 97 +S+ V ++ E + LG+G +G V ++ +G+ A+K ++ V ++++ Sbjct: 150 VSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT 209 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 + + ++ PF + + ME + F+ + + + ED Sbjct: 210 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARF 266 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSVAKTIDAG 215 IV AL++LHS+ +V++RD+K N++++ G +K+ DFG+ G + KT G Sbjct: 267 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-CG 325 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 Y+APE + E N G +V D W LG+ M E+ R P+ + ++L +++ Sbjct: 326 TPEYLAPEVL--EDNDYGRAV--DWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEE 379 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFFT 315 + P E S LKK+ K+R E+MQH FF Sbjct: 380 IRFPR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 423 >6E9W-A nrPDB Length = 443 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 105/220 (47%), Gaps = 14/220 (6%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLD 101 ++ +KA+D E + +GRGA+G V+ +RH + ++ A+K + + + + D Sbjct: 95 RDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERD 154 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID--KGQTIPEDILGKIA 159 I M + P+ V + A + +++ ME M +++ +PE Sbjct: 155 I-MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG------DLVNLMSNYDVPEKWARFYT 207 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCK 217 +V AL+ +HS + IHRDVKP N+L++ G +K+ DFG + D G Sbjct: 208 AEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTP 266 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 Y++PE + + Y + D WS+G+ + E+ + P+ Sbjct: 267 DYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPF 306 >2QNJ-A nrPDB Length = 328 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 66/255 (25%), Positives = 127/255 (49%), Gaps = 16/255 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +G+G + V+ RH+ +G+ +A+K I T +N ++L ++ I M+ ++ P V + Sbjct: 20 IGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI-MKILNHPNIVKLFE 78 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + E +++ ME S + + ++ G+ ++ K IV A+++ H K ++H Sbjct: 79 VIETEKTLYLIMEY--ASGGEVFDYLVAHGRMKEKEARSKFR-QIVSAVQYCHQK-RIVH 134 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--PYMAPERINPELNQKGYS 235 RD+K N+L++A +K+ DFG S +V +D C PY APE +K Sbjct: 135 RDLKAENLLLDADMNIKIADFGFSNEF--TVGGKLDTFCGSPPYAAPELFQ---GKKYDG 189 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 + D+WSLG+ + L P+D G ++L++ V ++P S + + + L Sbjct: 190 PEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPF-YMSTDCENLLKRFL 246 Query: 296 KKNSKERPTYPELMQ 310 N +R T ++M+ Sbjct: 247 VLNPIKRGTLEQIMK 261 >4AGU-A nrPDB Length = 311 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 126/300 (42%), Gaps = 56/300 (18%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 E I ++G G+YGVV K R+ +GQI+A+K+ + + K++ + ++ + P V Sbjct: 6 EKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLV 65 Query: 114 TFYGALFREGDVWICMELMDTS----LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 R+ + + E D + LD++ + V PE ++ I ++A+ Sbjct: 66 NLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGV-------PEHLVKSITWQTLQAVNFC 118 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGI-------SGYLVDSVAKTIDAGCKPYMAP 222 H K + IHRDVKP N+LI +K+CDFG S Y D VA + Y +P Sbjct: 119 H-KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVAT------RWYRSP 171 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI-------------LRFPYDSWGTPFQQLKQ 269 E + + Y D+W++G EL L + G + +Q Sbjct: 172 ELL---VGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQ 228 Query: 270 V---------VEEPSP------QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 V V+ P P +L S + CL + ER T +L+ HP+F Sbjct: 229 VFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >4D28-A nrPDB Length = 446 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 123/261 (47%), Gaps = 18/261 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 117 +G G + V+ R+ +G +A+K + + + + + +IS M+ V P V Y Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 L + ++I +E + + + +++ KG+ + ED K +V A+ H HSK V H Sbjct: 77 VLASKSKIYIVLEFVTGG--ELFDRIVHKGR-LKEDESRKYFQQLVDAVAHCHSK-GVYH 132 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA-GCKPYMAPERINPELNQKGY-S 235 RD+KP N+L++ G +K+ DFG+S + V D G Y+APE L+ +GY Sbjct: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPE----VLSGQGYDG 188 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPADKFSAEFVDFTSQ 293 +DIWS G+ + + P+ P ++++ + P FSAE + Sbjct: 189 SAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPW-----FSAEVKFLIHR 243 Query: 294 CLKKNSKERPTYPELMQHPFF 314 L N K R + + P+F Sbjct: 244 ILDPNPKTRIQIQGIKKDPWF 264 >2HAK-A nrPDB Length = 328 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 113/224 (50%), Gaps = 15/224 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +G+G + V+ RHV +G+ +AVK I T +N ++L ++ I M+ ++ P V + Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRI-MKILNHPNIVKLFE 81 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + E +++ ME S + + ++ G+ ++ K IV A+++ H K ++H Sbjct: 82 VIETEKTLYLVMEY--ASGGEVFDYLVAHGRMKEKEARAKFR-QIVSAVQYCHQKY-IVH 137 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--PYMAPERINPELNQKGYS 235 RD+K N+L++ +K+ DFG S +V +D C PY APE +K Sbjct: 138 RDLKAENLLLDGDMNIKIADFGFSNEF--TVGNKLDTFCGSPPYAAPELFQ---GKKYDG 192 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 + D+WSLG+ + L P+D G ++L++ V ++P Sbjct: 193 PEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIP 234 >3MN3-A nrPDB Length = 271 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/258 (25%), Positives = 119/258 (46%), Gaps = 14/258 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 117 LG G++G V+ H +GQ +A+K I V ++ + ++ +IS +R + P + Y Sbjct: 12 LGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYD 71 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + + ++ + +E L + I + + E + I+ A+E+ H + ++H Sbjct: 72 VIKSKDEIIMVIEYAGNELFDY----IVQRDKMSEQEARRFFQQIISAVEYCH-RHKIVH 126 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVK 237 RD+KP N+L++ VK+ DFG+S + D G Y APE I+ +L + Sbjct: 127 RDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYA---GPE 183 Query: 238 SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-SAEFVDFTSQCLK 296 D+WS G+ + + R P+D P L + + LP KF S + L Sbjct: 184 VDVWSCGVILYVMLCRRLPFDDESIPV--LFKNISNGVYTLP--KFLSPGAAGLIKRMLI 239 Query: 297 KNSKERPTYPELMQHPFF 314 N R + E+MQ +F Sbjct: 240 VNPLNRISIHEIMQDDWF 257 >5IG1-A nrPDB Length = 344 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/273 (25%), Positives = 128/273 (46%), Gaps = 22/273 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +G+GA+ V + + +G++ AVK I ++ S E ++ ++ I ++ V+ Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGIC-SSLQHEHIVSMRR 83 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 A E ++ E + S + + +++ + + E I+ AL+H HSK ++IH Sbjct: 84 AFRDESHFYLVFEYV--SGGELFDEIVTR-KFYNEKDASACMHQILSALQHCHSK-NIIH 139 Query: 178 RDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 RD+KP N+L+ + VK+ DFG++ + AG Y++PE I + Y Sbjct: 140 RDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIR----RVPY 195 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE-----PSPQLPADKFSAEFVD 289 D+W+ G+ + L + P+ W Q+L ++ PSP+ D + + Sbjct: 196 DTAVDVWACGVILYILLVGYPPF--WEEDHQKLYAQIKNCQYDFPSPEW--DSVTTAAKE 251 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 L+ N K RPT EL+QHP+ + G+ Sbjct: 252 LIKAMLEPNPKRRPTVQELLQHPWIARRDVPGS 284 >4BBM-A nrPDB Length = 331 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 72/312 (23%), Positives = 136/312 (43%), Gaps = 45/312 (14%) Query: 39 ISIGNQNFEVKA-DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL 97 + +G +N ++ + E + +G G+YG+V K R+ +G+I+A+K+ + + + K++ Sbjct: 12 VDLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIA 71 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE----D 153 M ++ + V ++ ++ E +D + ++D + P Sbjct: 72 MREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHT-------ILDDLELFPNGLDYQ 124 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID 213 ++ K I+ + HS ++IHRD+KP N+L++ G VK+CDFG + L D Sbjct: 125 VVQKYLFQIINGIGFCHSH-NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDD 183 Query: 214 -AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDS----------- 259 + Y APE + ++ Y D+W++G + E+ + FP DS Sbjct: 184 EVATRWYRAPELLVGDVK---YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMC 240 Query: 260 WGT--PFQQ-------------LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 G P Q L ++ E + K S +D +CL + +RP Sbjct: 241 LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF 300 Query: 305 YPELMQHPFFTL 316 EL+ H FF + Sbjct: 301 CAELLHHDFFQM 312 >4XEY-B nrPDB Length = 408 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 129/292 (44%), Gaps = 26/292 (8%) Query: 28 TPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT 87 P R+ + +S +E++ D+ +LG G YG V + +AVK ++ Sbjct: 102 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE- 160 Query: 88 VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-- 145 ++ E + L + + M+ + P V G RE +I E M Y ++D Sbjct: 161 -DTMEVEEFLKEAAV-MKEIKHPNLVQLLGVCTREPPFYIITEFMT------YGNLLDYL 212 Query: 146 ---KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 Q + +L +A I A+E+L K + IHRD+ N L+ VK+ DFG+S Sbjct: 213 RECNRQEVNAVVLLYMATQISSAMEYLEKK-NFIHRDLAARNCLVGENHLVKVADFGLSR 271 Query: 203 YLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYD 258 L+ T AG K + APE L +S+KSD+W+ G+ + E+A PY Sbjct: 272 -LMTGDTYTAHAGAKFPIKWTAPE----SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP 326 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 G Q+ +++E+ + + + C + N +RP++ E+ Q Sbjct: 327 --GIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 376 >4CZT-A nrPDB Length = 464 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 67/262 (25%), Positives = 125/262 (47%), Gaps = 18/262 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 117 LG G + V+ R+V +G +A+K I + + + +IS M+ + P + + Sbjct: 19 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 78 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + + ++ +E + + + ++ G+ + ED K ++ A+++ HS+ V H Sbjct: 79 VMASKTKIYFVLEFVTGG--ELFDKISSNGR-LKEDEARKYFQQLINAVDYCHSR-GVYH 134 Query: 178 RDVKPSNVLINALGQVKMCDFGISGY----LVDSVAKTIDAGCKPYMAPERINPELNQKG 233 RD+KP N+L++A G +K+ DFG+S D + T G Y+APE I N KG Sbjct: 135 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTT-CGTPNYVAPEVI----NNKG 189 Query: 234 Y-SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTS 292 Y K+D+WS G+ + L P++ + L + + + P FSA Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFED--SNLTSLYKKIFKAEFTCPP-WFSASAKKLIK 246 Query: 293 QCLKKNSKERPTYPELMQHPFF 314 + L N R T+ E++++ +F Sbjct: 247 RILDPNPATRITFAEVIENEWF 268 >2WTK-B nrPDB Length = 373 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 76/304 (25%), Positives = 124/304 (40%), Gaps = 63/304 (20%) Query: 66 VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM-DLDISMRTVDCPFTVTFYGALFREGD 124 V R+ P+G+ + V+RI S E L +L +S + + P V + + + Sbjct: 26 TVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVS-KLFNHPNIVPYRATFIADNE 84 Query: 125 VWICMELM--DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKP 182 +W+ M ++ D +D + E + I ++KAL+++H + +HR VK Sbjct: 85 LWVVTSFMAYGSAKDLICTHFMDG---MNELAIAYILQGVLKALDYIH-HMGYVHRSVKA 140 Query: 183 SNVLINALGQV---------KMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 S++LI+ G+V M G +V K P+++PE + + N +G Sbjct: 141 SHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPK-YSVKVLPWLSPEVL--QQNLQG 197 Query: 234 YSVKSDIWSLGITMIELAILRFPY---------------------DSWGTPFQQLKQ--- 269 Y KSDI+S+GIT ELA P+ D+ P ++L Sbjct: 198 YDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPS 257 Query: 270 ------------VVEEP------SPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P SP P + FS F F QCL++N RP+ L+ Sbjct: 258 RSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLN 317 Query: 311 HPFF 314 H FF Sbjct: 318 HSFF 321 >5FET-A nrPDB Length = 847 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 112/227 (49%), Gaps = 35/227 (15%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLD 101 Q+ +V+ +LE +GRG +G V+ + H P+ A+K + R+ ++ +Q + ++ + Sbjct: 526 QDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLERE 585 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV- 160 I+ D PF + + D++ F +++ G+ D + K+ + Sbjct: 586 ITAEN-DHPFIIR------------LVRTFKDSNCFYFLTELVTGGELY--DAIRKLGLL 630 Query: 161 ----------SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK 210 SI+ A+E+LH + ++++RD+KP N+L++ G VK+ DFG + + A Sbjct: 631 SKPQAQFYLGSIILAIEYLHER-NIVYRDLKPENILLDKQGYVKLIDFGCAKK-IQGRAY 688 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 T+ G YMAPE I KGY DIW+LG+ + E P+ Sbjct: 689 TL-VGTPHYMAPEVILG----KGYGCTVDIWALGVCLYEFICGPLPF 730 >5AWM-A nrPDB Length = 394 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 73/255 (28%), Positives = 118/255 (46%), Gaps = 34/255 (13%) Query: 39 ISIGNQNFEVKAD--DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + +G+ NF + + +L PI G GA G+V + Q +A+K++ R N KR Sbjct: 33 VEVGDTNFTIHSRYINLRPI---GSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 89 Query: 96 LLMDLDISMRTVDCPFTVTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 + + M+ V+ + A L DV++ MELMD +L + + +D Sbjct: 90 AYREFKL-MKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLD---- 144 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 D + + ++ ++HLHS +IHRD+KPSN+++ A +K+ DFG++ + Sbjct: 145 --HDRMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL--AILRFP----YDSWGTP 263 T + Y APE I GY+ DIWS+G M E+ + FP D W Sbjct: 202 MTPYVVTRYYRAPEVI----LGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 257 Query: 264 FQQLKQVVEEPSPQL 278 +QL PSP Sbjct: 258 IEQLGT----PSPSF 268 >5Z33-A nrPDB Length = 425 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 124/259 (47%), Gaps = 36/259 (13%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91 DL + + NQ+F V + ELG+GAYG+V + + + +A+K++ + + Sbjct: 13 DLQGRKIFKVFNQDFIVD-ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKK 71 Query: 92 -EQKRLLMDLDI-----SMRTVDCPFTVTF-YGALFREGDVWICMELMDTSLDKFYKQVI 144 KR L ++ + R + C + + F E ++ ELM+ L +I Sbjct: 72 ILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNE--TYLYEELMECDL----AAII 125 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI---- 200 GQ + + I+ L+++HS +V+HRD+KP N+L+NA ++K+CDFG+ Sbjct: 126 RSGQPLTDAHFQSFIYQILCGLKYIHSA-NVLHRDLKPGNLLVNADCELKICDFGLARGF 184 Query: 201 -------SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL 253 +GY+ + VA + Y APE + L+ + Y+ D+WS+G + EL Sbjct: 185 SVDPEENAGYMTEYVA------TRWYRAPEIM---LSFQSYTKAIDVWSVGCILAELLGG 235 Query: 254 RFPYDSWGTPFQQLKQVVE 272 R P+ QL Q++ Sbjct: 236 R-PFFKGRDYVDQLNQILH 253 >3MV5-A nrPDB Length = 342 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/282 (25%), Positives = 130/282 (46%), Gaps = 19/282 (6%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-NSQEQKRLLMDL 100 G + V ++ E + LG+G +G V ++ +G+ A+K ++ V ++++ + Sbjct: 1 GAMDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 60 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + ++ PF + + ME + F+ + + + ED Sbjct: 61 NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARFYGA 117 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSVAKTIDAGCKP 218 IV AL++LHS+ +V++RD+K N++++ G +K+ DFG+ G + KT G Sbjct: 118 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF-CGTPE 176 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Y+APE + E N G +V D W LG+ M E+ R P+ + ++L +++ + Sbjct: 177 YLAPEVL--EDNDYGRAV--DWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRF 230 Query: 279 PADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFFT 315 P E S LKK+ K+R E+MQH FF Sbjct: 231 PR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 271 >4E7W-A nrPDB Length = 394 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/289 (26%), Positives = 132/289 (45%), Gaps = 44/289 (15%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G G++GVV + + V S ++ A+K++ Q+++ +L I MR V P V Sbjct: 48 IGNGSFGVVFQAKLVESDEV-AIKKVL-----QDKRFKNRELQI-MRIVKHPNVVDLKAF 100 Query: 119 LFREGD------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 + GD + + +E + ++ + + QT+P ++ ++++L ++HS Sbjct: 101 FYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHS- 159 Query: 173 LSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 + + HRD+KP N+L++ G +K+ DFG + L+ + Y APE I Sbjct: 160 IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELI---FGA 216 Query: 232 KGYSVKSDIWSLGITMIELAILR--FPYDS-----------WGTPF-QQLKQV----VEE 273 Y+ DIWS G M EL + FP +S GTP +Q+K + +E Sbjct: 217 TNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEH 276 Query: 274 PSPQLPADKFSAEF--------VDFTSQCLKKNSKERPTYPELMQHPFF 314 PQ+ FS F +D S+ L+ R T E + HPFF Sbjct: 277 KFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >6QAU-A nrPDB Length = 280 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 77/282 (27%), Positives = 127/282 (45%), Gaps = 28/282 (9%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDIS 103 +FE DL +G GA+ VV + RH +A+K I S+ Q L ++ I Sbjct: 10 DFEYSKRDL-----VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKI- 63 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 ++ + V Y V++ ME + Y Q KG T+ ED + I Sbjct: 64 LKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQA--KG-TLSEDTIRVFLHQIA 120 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALG---------QVKMCDFGISGYLVDSVAKTIDA 214 A+ LHSK +IHRD+KP N+L++ ++K+ DFG + YL ++ Sbjct: 121 AAMRILHSK-GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLC 179 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G YMAPE I + Y K+D+WS+G + + + + P+ + +P Q L+ E+ Sbjct: 180 GSPMYMAPEVIMSQ----HYDAKADLWSIGTVIYQCLVGKPPFQA-NSP-QDLRMFYEKN 233 Query: 275 SPQLPA--DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 +P+ + S + L++N K+R + HPF Sbjct: 234 RSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL 275 >4GS6-A nrPDB Length = 315 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 121/258 (46%), Gaps = 23/258 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +GRGA+GVV K + + +A+K+I + E+K +++L + V+ P V YGA Sbjct: 17 VGRGAFGVVCKAKW--RAKDVAIKQIES---ESERKAFIVELR-QLSRVNHPNIVKLYGA 70 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI---AVSIVKALEHLHSKL-- 173 +C+ +M+ + V+ + +P + + + +LHS Sbjct: 71 CLNP----VCL-VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPK 125 Query: 174 SVIHRDVKPSNVLINALGQV-KMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQK 232 ++IHRD+KP N+L+ A G V K+CDFG + + + T + G +MAPE Sbjct: 126 ALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHM--TNNKGSAAWMAPEV----FEGS 179 Query: 233 GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTS 292 YS K D++S GI + E+ R P+D G P ++ V + + Sbjct: 180 NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMT 239 Query: 293 QCLKKNSKERPTYPELMQ 310 +C K+ +RP+ E+++ Sbjct: 240 RCWSKDPSQRPSMEEIVK 257 >5UUU-A nrPDB Length = 547 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 74/284 (26%), Positives = 130/284 (45%), Gaps = 27/284 (9%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 103 N + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 192 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 251 Query: 104 MRTV---DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + V DCPF V A + ++LM+ D Y + + E + A Sbjct: 252 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG-DLHYH--LSQHGVFSEADMRFYAA 308 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCKP 218 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ D K A G Sbjct: 309 EIILGLEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLA---CDFSKKKPHASVGTHG 364 Query: 219 YMAPERINPELNQKG--YSVKSDIWSLGITMIELAILRFPYDSWGTP-FQQLKQVVEEPS 275 YMAPE + QKG Y +D +SLG + +L P+ T ++ ++ + Sbjct: 365 YMAPEVL-----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 419 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 +LP D FS E L+++ R E+ + PFF Sbjct: 420 VELP-DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 462 >4O2Z-A nrPDB Length = 377 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 133/298 (44%), Gaps = 45/298 (15%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ-KRLLMDLDISMRTV---DCPFTVT 114 LG GAYG+ +G+ +++K+ R E KR+L ++D+ MR + V Sbjct: 53 LGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDM-MRFFHHENLLNVVN 111 Query: 115 FYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 L RE DV++ LMD ++ V+ Q + E + I++ L++LH Sbjct: 112 ILPPLKREYHSFEDVYVVTPLMDVDMN----VVLRSRQVLEESHMQYFVYQILRGLKYLH 167 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPEL 229 S +V HRD+KP+N++ N ++K+ DFG+S + ++ D + Y PE + L Sbjct: 168 SA-NVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELL---L 223 Query: 230 NQKGYSVKSDIWSLGITMIELAI-------------LRFPYDSWGTP-------FQQLKQ 269 YS DIWS+G E+ LR G P + L++ Sbjct: 224 ENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEK 283 Query: 270 VVEEPSPQL------PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT-LHESK 320 + E P L P + E +DF S+ + +RPT +++ HP+ LH+ + Sbjct: 284 LNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEE 341 >2JDO-A nrPDB Length = 342 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 73/281 (25%), Positives = 130/281 (46%), Gaps = 20/281 (7%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN-SQEQKRLLMDL 100 G + +V +D + + LG+G +G V +R +G+ A+K +R V ++++ + Sbjct: 1 GAMDPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE 60 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 ++ PF A + ME + F+ + + + E+ Sbjct: 61 SRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH---LSRERVFTEERARFYGA 117 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSVAKTIDAGCKP 218 IV ALE+LHS+ V++RD+K N++++ G +K+ DFG+ G + KT G Sbjct: 118 EIVSALEYLHSR-DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTF-CGTPE 175 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Y+APE + E N G +V D W LG+ M E+ R P+ + ++L +++ + Sbjct: 176 YLAPEVL--EDNDYGRAV--DWWGLGVVMYEMMCGRLPF--YNQDHERLFELILMEEIRF 229 Query: 279 PADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 P S E + LKK+ K+R E+M+H FF Sbjct: 230 PR-TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >2Y7J-A nrPDB Length = 365 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 64/268 (23%), Positives = 122/268 (45%), Gaps = 18/268 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL-------LMDLDISMRTVDCPF 111 +GRG VV + H +G AVK + T ++L + I + P Sbjct: 102 IGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPH 161 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 +T + +++ +LM + + + +K + E I S+++A+ LH+ Sbjct: 162 IITLIDSYESSSFMFLVFDLMRKG--ELFDYLTEK-VALSEKETRSIMRSLLEAVSFLHA 218 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 +++HRD+KP N+L++ Q+++ DFG S +L G Y+APE + +++ Sbjct: 219 N-NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDE 277 Query: 232 K--GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DKFSAE 286 GY + D+W+ G+ + L P+ W + +++ E Q + D S+ Sbjct: 278 THPGYGKEVDLWACGVILFTLLAGSPPF--WHRRQILMLRMIMEGQYQFSSPEWDDRSST 335 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFF 314 D S+ L+ + + R T + +QHPFF Sbjct: 336 VKDLISRLLQVDPEARLTAEQALQHPFF 363 >1UA2-A nrPDB Length = 346 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 57/229 (24%), Positives = 113/229 (49%), Gaps = 14/229 (6%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDISM 104 +A E + LG G + V K R + QI+A+K+I+ S+ + + L ++ + + Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL-L 66 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + P + A + ++ + + M+T L+ K D + + + ++ Sbjct: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMTLQ 123 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPE 223 LE+LH ++HRD+KP+N+L++ G +K+ DFG++ + + A T + Y APE Sbjct: 124 GLEYLHQHW-ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 + + Y V D+W++G + EL +LR P+ + QL ++ E Sbjct: 183 LL---FGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFE 227 >2OU7-A nrPDB Length = 335 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 73/261 (27%), Positives = 129/261 (49%), Gaps = 17/261 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM-RTVDCPFTVTFYG 117 LG+G + ++ + ++ A K + ++ + +R M ++IS+ R++ V F+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 118 ALFREGD-VWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 F + D V++ +EL SL + +K+ K T PE IV ++LH V Sbjct: 109 -FFEDNDFVFVVLELCRRRSLLELHKR--RKALTEPEA--RYYLRQIVLGCQYLHRN-RV 162 Query: 176 IHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPELNQKGY 234 IHRD+K N+ +N +VK+ DFG++ + D K + G Y+APE L++KG+ Sbjct: 163 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPE----VLSKKGH 218 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 S + D+WS+G M L + + P+++ L+ E S + +A + + Sbjct: 219 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLI---QKM 275 Query: 295 LKKNSKERPTYPELMQHPFFT 315 L+ + RPT EL+ FFT Sbjct: 276 LQTDPTARPTINELLNDEFFT 296 >3PVW-A nrPDB Length = 695 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 74/284 (26%), Positives = 130/284 (45%), Gaps = 27/284 (9%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 103 N + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 Query: 104 MRTV---DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + V DCPF V A + ++LM+ D Y + + E + A Sbjct: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGG-DLHYH--LSQHGVFSEADMRFYAA 299 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCKP 218 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ D K A G Sbjct: 300 EIILGLEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLA---CDFSKKKPHASVGTHG 355 Query: 219 YMAPERINPELNQKG--YSVKSDIWSLGITMIELAILRFPYDSWGTP-FQQLKQVVEEPS 275 YMAPE + QKG Y +D +SLG + +L P+ T ++ ++ + Sbjct: 356 YMAPEVL-----QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMA 410 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 +LP D FS E L+++ R E+ + PFF Sbjct: 411 VELP-DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 >2FO0-A nrPDB Length = 495 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 129/292 (44%), Gaps = 26/292 (8%) Query: 28 TPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT 87 P R+ + +S +E++ D+ +LG G YG V + +AVK ++ Sbjct: 194 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE- 252 Query: 88 VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-- 145 ++ E + L + + M+ + P V G RE +I E M Y ++D Sbjct: 253 -DTMEVEEFLKEAAV-MKEIKHPNLVQLLGVCTREPPFYIITEFMT------YGNLLDYL 304 Query: 146 ---KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 Q + +L +A I A+E+L K + IHR++ N L+ VK+ DFG+S Sbjct: 305 RECNRQEVNAVVLLYMATQISSAMEYLEKK-NFIHRNLAARNCLVGENHLVKVADFGLS- 362 Query: 203 YLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYD 258 L+ T AG K + APE L +S+KSD+W+ G+ + E+A PY Sbjct: 363 RLMTGDTYTAHAGAKFPIKWTAPE----SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP 418 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 G Q+ +++E+ + + + C + N +RP++ E+ Q Sbjct: 419 --GIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 468 >4J52-A nrPDB Length = 293 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 73/261 (27%), Positives = 129/261 (49%), Gaps = 17/261 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM-RTVDCPFTVTFYG 117 LG+G + ++ + ++ A K + ++ + +R M ++IS+ R++ V F+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 118 ALFREGD-VWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 F + D V++ +EL SL + +K+ K T PE IV ++LH V Sbjct: 82 -FFEDNDFVFVVLELCRRRSLLELHKR--RKALTEPEA--RYYLRQIVLGCQYLHRN-RV 135 Query: 176 IHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPELNQKGY 234 IHRD+K N+ +N +VK+ DFG++ + D K + G Y+APE L++KG+ Sbjct: 136 IHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPE----VLSKKGH 191 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 S + D+WS+G M L + + P+++ L+ E S + +A + + Sbjct: 192 SFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLI---QKM 248 Query: 295 LKKNSKERPTYPELMQHPFFT 315 L+ + RPT EL+ FFT Sbjct: 249 LQTDPTARPTINELLNDEFFT 269 >3OZ6-A nrPDB Length = 388 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 69/252 (27%), Positives = 119/252 (47%), Gaps = 38/252 (15%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFT 112 E + +LG+GAYG+V K +G+++AVK+I A NS + +R ++ I Sbjct: 12 ELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENI 71 Query: 113 VTFYGALFREGD--VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV-SIVKALEHL 169 V L + D V++ + M+T L + I E + + V ++K +++L Sbjct: 72 VNLLNVLRADNDRDVYLVFDYMETDLHAVIRA------NILEPVHKQYVVYQLIKVIKYL 125 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD----------SVAKTID------ 213 HS ++HRD+KPSN+L+NA VK+ DFG+S V+ S+ + + Sbjct: 126 HSG-GLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQ 184 Query: 214 ------AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQ 265 + Y APE + L Y+ D+WSLG + E+ + FP S + Sbjct: 185 PILTDYVATRWYRAPEIL---LGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 266 QLKQVVEEPSPQ 277 ++ V++ PS + Sbjct: 242 RIIGVIDFPSNE 253 >4KRC-A nrPDB Length = 317 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 131/298 (43%), Gaps = 53/298 (17%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFY 116 +LG G Y V K + +G +A+K ++ ++S+E +IS M+ + V Y Sbjct: 12 KLGNGTYATVYKGLNKTTGVYVALKEVK--LDSEEGTPSTAIREISLMKELKHENIVRLY 69 Query: 117 GALFREGDVWICMELMDTSLDKFY--KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + E + + E MD L K+ + V + + + +++ +++ L H Sbjct: 70 DVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN-K 128 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 ++HRD+KP N+LIN GQ+K+ DFG++ G V++ + + Y AP+ + + Sbjct: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW--YRAPDVL---MGS 183 Query: 232 KGYSVKSDIWSLGITMIELAI-------------LRFPYDSWGTP--------------- 263 + YS DIWS G + E+ L+ +D GTP Sbjct: 184 RTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYN 243 Query: 264 --FQQ-----LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 QQ L+QV+ +P + P D +DF L+ N R + + + HP+F Sbjct: 244 PNIQQRPPRDLRQVL-QPHTKEPLD---GNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 >5GNK-A nrPDB Length = 297 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 75/272 (27%), Positives = 119/272 (43%), Gaps = 23/272 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K + + I LG GA+G V K +P G+ + A+K +R + + K +L D Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL-DEAYV 74 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M +VD P G V + M+LM V + I L V I Sbjct: 75 MASVDNPHVCRLLGICL-TSTVQLIMQLM--PFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYM 220 K + +L + ++HRD+ NVL+ VK+ DFG++ L + G K +M Sbjct: 132 KGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 190 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPSPQ 277 A E I + Y+ +SD+WS G+T+ EL PYD G P ++ ++E E PQ Sbjct: 191 ALESILHRI----YTHQSDVWSYGVTVWELMTFGSKPYD--GIPASEISSILEKGERLPQ 244 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 P + +C ++ RP + EL+ Sbjct: 245 PPICTIDVYMI--MVKCWMIDADSRPKFRELI 274 >6FDY-U nrPDB Length = 276 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 129/269 (47%), Gaps = 27/269 (10%) Query: 59 LGRGAYGVVEK-MRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG G Y V K + +++A+K + + ++N + LL +++I ++ + P V Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI-LKGIRHPHIVQLK 77 Query: 117 GALFREGDVWICMEL-MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ++++ ME L +F I + +PE + + AL+ LH + ++ Sbjct: 78 DFQWDSDNIYLIMEFCAGGDLSRF----IHTRRILPEKVARVFMQQLASALQFLHER-NI 132 Query: 176 IHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 H D+KP N+L+++L + +K+ DFG + ++ K + G YMAPE + Q+ Sbjct: 133 SHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVC----QRQ 188 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ------VVEEPSPQLPADKFSAEF 287 Y + D+WS+G+ + E + P+ S F +L++ V+E P L S + Sbjct: 189 YDARVDLWSMGVILYEALFGQPPFAS--RSFSELEEKIRSNRVIELPLRPL----LSRDC 242 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFTL 316 D + L+++ R ++ + HP+ L Sbjct: 243 RDLLQRLLERDPSRRISFQDFFAHPWVDL 271 >6NPU-A nrPDB Length = 298 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 127/287 (44%), Gaps = 26/287 (9%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E++ D+ +LG G YG V + +AVK ++ ++ E + L + + M+ Sbjct: 21 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE--DTMEVEEFLKEAAV-MK 77 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-----KGQTIPEDILGKIAV 160 + P V G RE +I E M Y ++D Q + +L +A Sbjct: 78 EIKHPNLVQLLGVCTREPPFYIITEFMT------YGNLLDYLRECNRQEVNAVVLLYMAT 131 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--- 217 I A+E+L K + IHRD+ N L+ VK+ DFG+S L+ T AG K Sbjct: 132 QISSAMEYLEKK-NFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPI 189 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVEEPSP 276 + APE L +S+KSD+W+ G+ + E+A PY G Q+ +++E+ Sbjct: 190 KWTAPES----LAYNKFSIKSDVWAFGVLLWEIATYGMSPYP--GIDLSQVYELLEKDYR 243 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 + + + C + N +RP++ E+ Q ES +D Sbjct: 244 MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 290 >3TKU-A nrPDB Length = 433 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 113/230 (49%), Gaps = 31/230 (13%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-------RA-TVNSQEQKR 95 + ++ +D E I +GRGA+G V ++ + +I A+K + RA T +E++ Sbjct: 83 KEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERD 142 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMEL-----MDTSLDKFYKQVIDKGQTI 150 +L++ DC + + A E +++ M+ + T L KF + + Sbjct: 143 VLVN-------GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDK-------L 188 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SV 208 PED+ +V A++ +H +L +HRD+KP NVL++ G +++ DFG + D +V Sbjct: 189 PEDMARFYIGEMVLAIDSIH-QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTV 247 Query: 209 AKTIDAGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPY 257 ++ G Y++PE + + G Y + D WSLG+ M E+ P+ Sbjct: 248 QSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >4EWQ-A nrPDB Length = 383 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 81/306 (26%), Positives = 135/306 (44%), Gaps = 58/306 (18%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI----RATVNSQEQKRLLMDLD--- 101 + +L P+ G GAYG V +G +AVK++ ++ ++++ R L L Sbjct: 46 RYQNLSPV---GSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK 102 Query: 102 ----ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 I + V P +L DV++ LM L+ I K Q + +D + Sbjct: 103 HENVIGLLDVFTPAR-----SLEEFNDVYLVTHLMGADLNN-----IVKCQKLTDDHVQF 152 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217 + I++ L+++HS +IHRD+KPSN+ +N ++K+ DFG++ + D + + + Sbjct: 153 LIYQILRGLKYIHSA-DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYV--ATR 209 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSW-----------GTPF 264 Y APE + LN Y+ DIWS+G M EL R FP GTP Sbjct: 210 WYRAPEIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 266 Query: 265 QQLKQVVEEPSP--------QLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELM 309 +L + + S Q+P F+ F VD + L +S +R T + + Sbjct: 267 AELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQAL 326 Query: 310 QHPFFT 315 H +F Sbjct: 327 AHAYFA 332 >3PP0-A nrPDB Length = 338 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 76/274 (27%), Positives = 130/274 (47%), Gaps = 27/274 (9%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K +L + LG GA+G V K +P G+ + A+K +R + + K +L D Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEIL-DEAYV 72 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTS--LDKFYKQVIDKGQTIPEDILGKIAVS 161 M V P+ G V + +LM LD + ++G+ +D+L + Sbjct: 73 MAGVGSPYVSRLLGICL-TSTVQLVTQLMPYGCLLDHVRE---NRGRLGSQDLL-NWCMQ 127 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKP-- 218 I K + +L + ++HRD+ NVL+ + VK+ DFG++ L +D D G P Sbjct: 128 IAKGMSYLED-VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIK 186 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVE--EPS 275 +MA E I ++ ++ +SD+WS G+T+ EL PYD G P +++ ++E E Sbjct: 187 WMALESI----LRRRFTHQSDVWSYGVTVWELMTFGAKPYD--GIPAREIPDLLEKGERL 240 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 PQ P + +C +S+ RP + EL+ Sbjct: 241 PQPPICTIDVYMI--MVKCWMIDSECRPRFRELV 272 >2VN9-A nrPDB Length = 301 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 132/271 (48%), Gaps = 19/271 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA-TVNSQEQKRLLMDLDISMRTVDC 109 D+ + ELG+GA+ VV + +P+GQ A K I +++++ ++L + I R + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC-RLLKH 62 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V + ++ EG ++ +L+ + ++ ++ + + E I++++ H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILESVNHC 119 Query: 170 HSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERI 225 H ++HRD+KP N+L+ + + VK+ DFG++ + D A AG Y++PE Sbjct: 120 HLN-GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV- 177 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DK 282 L + Y D+W+ G+ + L + P+ W +L Q ++ + P+ D Sbjct: 178 ---LRKDPYGKPVDMWACGVILYILLVGYPPF--WDEDQHRLYQQIKAGAYDFPSPEWDT 232 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 + E D ++ L N +R T E ++HP+ Sbjct: 233 VTPEAKDLINKMLTINPAKRITASEALKHPW 263 >3BBT-B nrPDB Length = 328 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/271 (27%), Positives = 123/271 (45%), Gaps = 23/271 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K +L+ + LG GA+G V K VP G+ + A+K + T + MD + Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEF-MDEALI 70 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M ++D P V G + + +LM + V + I +L V I Sbjct: 71 MASMDHPHLVRLLGVCLSP-TIQLVTQLMPHGC--LLEYVHEHKDNIGSQLLLNWCVQIA 127 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKP--YM 220 K + +L + ++HRD+ NVL+ + VK+ DFG++ L D D G P +M Sbjct: 128 KGMMYLEER-RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWM 186 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVE--EPSPQ 277 A E I + + ++ +SD+WS G+T+ EL PYD G P +++ ++E E PQ Sbjct: 187 ALECI----HYRKFTHQSDVWSYGVTIWELMTFGGKPYD--GIPTREIPDLLEKGERLPQ 240 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 P V +C ++ RP + EL Sbjct: 241 PPICTIDVYMV--MVKCWMIDADSRPKFKEL 269 >5LOH-A nrPDB Length = 341 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 68/268 (25%), Positives = 123/268 (45%), Gaps = 24/268 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 + RGA+G V + G++ AVK ++ +N ++ + D ++ PF V Y Sbjct: 44 ISRGAFGKVYLGQK--GGKLYAVKVVKKADMINKNMTHQVQAERD-ALALSKSPFIVHLY 100 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 +L +V++ ME + + K ++ E++ K + AL++LH + +I Sbjct: 101 YSLQSANNVYLVMEYL---IGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLH-RHGII 156 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-------AGCKPYMAPERINPEL 229 HRD+KP N+LI+ G +K+ DFG+S ++ +D G Y+APE L Sbjct: 157 HRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPEL----L 212 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE--PSPQLPADKFSAEF 287 + + D W+LG+ + E P++ TP Q + +++ P P+ +K S Sbjct: 213 LGRAHGPAVDWWALGVCLFEFLTGIPPFND-ETPQQVFQNILKRDIPWPE-GEEKLSDNA 270 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFT 315 L + +R EL +HP F+ Sbjct: 271 QSAVEILLTIDDTKRAGMKELKRHPLFS 298 >2W96-B nrPDB Length = 306 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 99/210 (47%), Gaps = 25/210 (11%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLLMDLDI---- 102 EP+ E+G GAYG V K R SG +A+K +R +++ + LL L+ Sbjct: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHP 66 Query: 103 -SMRTVD-CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +R +D C + T RE V + E +D L + + G +P + + + Sbjct: 67 NVVRLMDVCATSRTD-----REIKVTLVFEHVDQDLRTYLDKAPPPG--LPAETIKDLMR 119 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 ++ L+ LH+ ++HRD+KP N+L+ + G VK+ DFG++ +A Y Sbjct: 120 QFLRGLDFLHAN-CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYR 178 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIEL 250 APE L Q Y+ D+WS+G E+ Sbjct: 179 APE----VLLQSTYATPVDMWSVGCIFAEM 204 >3UC3-A nrPDB Length = 361 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISMRTV 107 +D + + ++G G +GV MR + +++AVK I A ++ Q+ + I+ R++ Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREI-----INHRSL 73 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 P V F + + I ME S + Y+++ + G+ ED ++ + Sbjct: 74 RHPNIVRFKEVILTPTHLAIIMEY--ASGGELYERICNAGR-FSEDEARFFFQQLLSGVS 130 Query: 168 HLHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 + HS + + HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 131 YCHS-MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 189 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-K 282 L Q+ +D+WS G+T+ + + +P++ P +++ Q + +P D + Sbjct: 190 ---LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E S+ + R + PE+ H +F Sbjct: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >5MJB-A nrPDB Length = 305 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/263 (26%), Positives = 122/263 (46%), Gaps = 22/263 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +G G +G V K R G+ +A+K ++A + ++++ L + I M D + Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASI-MGQFDHRNIIRL 92 Query: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G + + V I E M+ +LD F +Q + GQ ++G + I +++L S+++ Sbjct: 93 EGVVTKSRPVMIITEFMENCALDSFLRQ--NDGQFTVIQLVGMLR-GIAAGMKYL-SEMN 148 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK---TIDAGCK---PYMAPERINPE 228 +HRD+ N+L+N+ K+ DFG+S YL D + T G K + APE I Sbjct: 149 YVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAI--- 205 Query: 229 LNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 + ++ SD+WS GI M E ++ PY W Q + +E+ P A Sbjct: 206 -AYRKFTSASDVWSYGIVMWEVMSFGERPY--WDMSNQDVINAIEQDYRLPPPMDCPAAL 262 Query: 288 VDFTSQCLKKNSKERPTYPELMQ 310 C +K+ RP + E++ Sbjct: 263 HQLMLDCWQKDRNSRPRFAEIVN 285 >1JNK-A nrPDB Length = 423 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/244 (27%), Positives = 114/244 (46%), Gaps = 30/244 (12%) Query: 39 ISIGNQNFEV--KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + +G+ F V + +L+PI G GA G+V + +A+K++ R N KR Sbjct: 51 VEVGDSTFTVLKRYQNLKPI---GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQT 149 +L + M+ V+ ++ + DV++ MELMD +L + + +D + Sbjct: 108 AYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER- 165 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ S Sbjct: 166 -----MSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 219 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI--LRFP----YDSWGTP 263 T + Y APE I GY DIWS+G M E+ + FP D W Sbjct: 220 MTPYVVTRYYRAPEVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 275 Query: 264 FQQL 267 +QL Sbjct: 276 IEQL 279 >4TNB-A nrPDB Length = 590 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 128/266 (48%), Gaps = 19/266 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+G +G V + +G++ A KR+ + + ++ + + ++ + V+ F V Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQ-TIPEDILGKIAVSIVKALEHLHSKLSVI 176 A + + + + +M+ KF+ + + G E+ A I+ LE LH + + + Sbjct: 252 AYETKDALCLVLTIMNGGDLKFH--IYNMGNPGFEEERALFYAAEILCGLEDLHHE-NTV 308 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 +RD+KP N+L++ G +++ D G++ + + G YMAPE +N NQ+ Y + Sbjct: 309 YRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLN---NQR-YGL 364 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQL---KQVVEEPSPQLPADKFSAEFVDFTSQ 293 D W LG + E+ + P+ ++ ++V+E + ++ + KFS E Sbjct: 365 SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLE--TEEVYSHKFSEEAKSICKM 422 Query: 294 CLKKNSKER-----PTYPELMQHPFF 314 L K++K+R E+ +HPFF Sbjct: 423 LLTKDAKQRLGCQEEEAAEVKRHPFF 448 >3LZB-A nrPDB Length = 327 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 75/272 (27%), Positives = 119/272 (43%), Gaps = 23/272 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K + + I LG GA+G V K +P G+ + A+K +R + + K +L D Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL-DEAYV 70 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M +VD P G V + +LM Y V + I L V I Sbjct: 71 MASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDY--VREHKDNIGSQYLLNWCVQIA 127 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYM 220 K + +L + ++HRD+ NVL+ VK+ DFG++ L + G K +M Sbjct: 128 KGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 186 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPSPQ 277 A E I + Y+ +SD+WS G+T+ EL PYD G P ++ ++E E PQ Sbjct: 187 ALESILHRI----YTHQSDVWSYGVTVWELMTFGSKPYD--GIPASEISSILEKGERLPQ 240 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 P + +C ++ RP + EL+ Sbjct: 241 PPICTIDVYMI--MRKCWMIDADSRPKFRELI 270 >3FI2-A nrPDB Length = 353 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 126/285 (44%), Gaps = 43/285 (15%) Query: 39 ISIGNQNFEV--KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + +G+ F V + +L+PI G GA G+V + +A+K++ R N KR Sbjct: 13 VEVGDSTFTVLKRYQNLKPI---GSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQT 149 +L + M+ V+ ++ + DV++ MELMD +L + + +D + Sbjct: 70 AYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHER- 127 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ S Sbjct: 128 -----MSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 181 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI--LRFP----YDSWGTP 263 T + Y APE I GY DIWS+G M E+ + FP D W Sbjct: 182 MTPYVVTRYYRAPEVI----LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKV 237 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +QL P P EF+ ++ + RP Y L Sbjct: 238 IEQLGT----PCP---------EFMKKLQPTVRNYVENRPKYAGL 269 >5X3F-B nrPDB Length = 393 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 34/263 (12%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSG-----------QIMAVKRIRATVNSQEQKRLLMD 99 D + I LG G++G V ++H SG +++ +K+I T+N +KR+L Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLN---EKRIL-- 138 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + V+ PF V + ++++ ME + + + + G+ E A Sbjct: 139 -----QAVNFPFLVKLEFSFKDNSNLYMVMEYVAGG--EMFSHLRRIGR-FSEPHARFYA 190 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 IV E+LHS L +I+RD+KP N+LI+ G +++ DFG + V T+ G Y Sbjct: 191 AQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL-CGTPEY 247 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +APE I KGY+ D W+LG+ + E+A P+ + P Q +++V + P Sbjct: 248 LAPEII----LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIV-SGKVRFP 301 Query: 280 ADKFSAEFVDFTSQCLKKNSKER 302 + FS++ D L+ + +R Sbjct: 302 S-HFSSDLKDLLRNLLQVDLTKR 323 >5N23-A nrPDB Length = 352 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 70/263 (26%), Positives = 124/263 (47%), Gaps = 33/263 (12%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSG-----------QIMAVKRIRATVNSQEQKRLLMD 99 D E I LG G++G V ++H +G +++ +K+I T+N +KR+ Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLN---EKRI--- 95 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + V+ PF V + ++++ +E + + + G+ E A Sbjct: 96 ----QQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGG--EMFSHLRRIGR-FSEPHARFYA 148 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 IV E+LHS L +I+RD+KP N+LI+ G +K+ DFG + + T+ G Y Sbjct: 149 AQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTL-CGTPEY 206 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +APE I KGY+ D W+LG+ + E+A P+ + P Q +++V + P Sbjct: 207 LAPEII----LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIV-SGKVRFP 260 Query: 280 ADKFSAEFVDFTSQCLKKNSKER 302 + FS++ D L+ + +R Sbjct: 261 SH-FSSDLKDLLRNLLQVDLTKR 282 >3GC9-A nrPDB Length = 370 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 75/302 (24%), Positives = 133/302 (44%), Gaps = 55/302 (18%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-------QEQKRLLMDLD---- 101 L+ + +G GAYG V Q +AVK++ S + RLL L Sbjct: 30 LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENV 89 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 I + V P T ++ +V++ LM L+ I K Q + ++ + + Sbjct: 90 IGLLDVFTPAT-----SIEDFSEVYLVTTLMGADLNN-----IVKSQALSDEHVQFLVYQ 139 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 +++ L+++HS +IHRD+KPSNV +N ++++ DFG++ + + + + Y A Sbjct: 140 LLRGLKYIHSA-GIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYV--ATRWYRA 196 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQ-- 277 PE + LN Y+ DIWS+G M EL + FP + +++ +VV PSP+ Sbjct: 197 PEIM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVL 253 Query: 278 -----------------LPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPF 313 +P S+ F +D + L +S +R + E + H + Sbjct: 254 AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAY 313 Query: 314 FT 315 F+ Sbjct: 314 FS 315 >6CMJ-A nrPDB Length = 321 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 49/159 (30%), Positives = 84/159 (52%), Gaps = 8/159 (5%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA-GCKPYM 220 ++K +E+LH + +IHRD+KPSN+L+ G +K+ DFG+S S A + G +M Sbjct: 152 LIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 210 Query: 221 APERINPELNQKGYSVKS-DIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 APE ++ +K +S K+ D+W++G+T+ + P+ L ++ + + P Sbjct: 211 APESLSE--TRKIFSGKALDVWAMGVTLYCFVFGQCPF--MDERIMCLHSKIKSQALEFP 266 Query: 280 ADKFSAE-FVDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 AE D ++ L KN + R PE+ HP+ T H Sbjct: 267 DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRH 305 >4WB7-A nrPDB Length = 405 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 104/212 (49%), Gaps = 31/212 (14%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSG-----------QIMAVKRIRATVNSQEQKRLLMD 99 D E I LG G++G V ++H +G +++ +K+I T+N +KR+L Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLN---EKRIL-- 150 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + V+ PF V + ++++ ME + + + + G+ E A Sbjct: 151 -----QAVNFPFLVKLEFSFKDNSNLYMVMEYVPGG--EMFSHLRRIGR-FSEPHARFYA 202 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 IV E+LHS L +I+RD+KP N+LI+ G +++ DFG + V T+ G Y Sbjct: 203 AQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-RVKGRTWTL-CGTPEY 259 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELA 251 +APE I KGY+ D W+LG+ + E+A Sbjct: 260 LAPEII----LSKGYNKAVDWWALGVLIYEMA 287 >4E93-A nrPDB Length = 377 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 72/269 (26%), Positives = 117/269 (43%), Gaps = 24/269 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 +DL ++GRG +G V R ++AVK R T+ + + L + I ++ P Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI-LKQYSHP 172 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V G ++ ++I MEL+ F + +G + L ++ +E+L Sbjct: 173 NIVRLIGVCTQKQPIYIVMELVQGG--DFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLE 230 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK----PYMAPERIN 226 SK IHRD+ N L+ +K+ DFG+S D V G + + APE Sbjct: 231 SK-CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAA-SGGLRQVPVKWTAPE--- 285 Query: 227 PELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEE----PSPQLPAD 281 LN YS +SD+WS GI + E ++ PY + QQ ++ VE+ P P+L D Sbjct: 286 -ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSN--QQTREFVEKGGRLPCPELCPD 342 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 QC +RP++ + Q Sbjct: 343 A----VFRLMEQCWAYEPGQRPSFSTIYQ 367 >4PWN-A nrPDB Length = 274 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/273 (23%), Positives = 122/273 (44%), Gaps = 32/273 (11%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 +E+GRG++ V K + +A ++ ++ +++ + ++ + P V FY Sbjct: 16 IEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFY 75 Query: 117 GALFREGDVW-----------ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 D W + ELM + K Y + + + + +L I+K Sbjct: 76 -------DSWESTVKGKKCIVLVTELMTSGTLKTY---LKRFKVMKIKVLRSWCRQILKG 125 Query: 166 LEHLHSKLS-VIHRDVKPSNVLINA-LGQVKMCDFGISGY-LVDSVAKTIDAGCKPYMAP 222 L+ LH++ +IHRD+K N+ I G VK+ D G++ S AK++ P Sbjct: 126 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIG------TP 179 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E + PE+ ++ Y D+++ G+ M+E+A +PY Q ++V P DK Sbjct: 180 EFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPA-SFDK 238 Query: 283 FSA-EFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + E + C+++N ER + +L+ H FF Sbjct: 239 VAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFF 271 >5U6Y-A nrPDB Length = 461 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/266 (24%), Positives = 128/266 (48%), Gaps = 19/266 (7%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 ELG+GA+ VV + V +GQ A K I +++++ ++L + I R + P V + Sbjct: 7 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARIC-RLLKHPNIVRLH 65 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 ++ EG ++ +L+ + ++ ++ + + E I++A+ H H ++ V+ Sbjct: 66 DSISEEGHHYLIFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILEAVLHCH-QMGVV 121 Query: 177 HRDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQK 232 HRD+KP N+L+ + VK+ DFG++ + AG Y++PE L + Sbjct: 122 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV----LRKD 177 Query: 233 GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DKFSAEFVD 289 Y D+W+ G+ + L + P+ W +L Q ++ + P+ D + E D Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPF--WDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 235 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFT 315 ++ L N +R T E ++HP+ + Sbjct: 236 LINKMLTINPSKRITAAEALKHPWIS 261 >3EB0-A nrPDB Length = 383 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/253 (25%), Positives = 112/253 (44%), Gaps = 50/253 (19%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG G++G+V ++ + SG+ A+K++ Q+ + +LDI M+ +D + Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKVL-----QDPRYKNRELDI-MKVLDHVNIIKLVDY 68 Query: 119 LFREGD--------------------------------------VWICMELMDTSLDKFY 140 + GD + + ME + +L K Sbjct: 69 FYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVL 128 Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL-GQVKMCDFG 199 K I G++IP +++ + +A+ +HS L + HRD+KP N+L+N+ +K+CDFG Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHS-LGICHRDIKPQNLLVNSKDNTLKLCDFG 187 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 + L+ S + Y APE + L Y+ D+WS+G EL IL P S Sbjct: 188 SAKKLIPSEPSVAYICSRFYRAPELM---LGATEYTPSIDLWSIGCVFGEL-ILGKPLFS 243 Query: 260 WGTPFQQLKQVVE 272 T QL ++++ Sbjct: 244 GETSIDQLVRIIQ 256 >2VZ6-A nrPDB Length = 313 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 67/285 (23%), Positives = 136/285 (47%), Gaps = 20/285 (7%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLL 97 + +G +N ++ + ELG+GA+ VV + V +GQ A K I +++++ ++L Sbjct: 11 VDLGTENLYFQSM-YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE 69 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 + I R + P V + ++ EG ++ +L+ + ++ ++ + + E Sbjct: 70 REARIC-RLLKHPNIVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAR-EYYSEADASH 125 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTID- 213 I++A+ H H ++ V+HRD+KP N+L+ + VK+ DFG++ + Sbjct: 126 CIQQILEAVLHCH-QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGF 184 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 AG Y++PE L + Y D+W+ G+ + L + P+ W +L Q ++ Sbjct: 185 AGTPGYLSPEV----LRKDPYGKPVDLWACGVILYILLVGYPPF--WDEDQHRLYQQIKA 238 Query: 274 PSPQLPA---DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + P+ D + E D ++ L N +R T E ++HP+ + Sbjct: 239 GAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >3E7O-A nrPDB Length = 360 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 75/291 (25%), Positives = 125/291 (42%), Gaps = 43/291 (14%) Query: 39 ISIGNQNFEV--KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + + + F V + L+PI G GA G+V G +AVK++ R N KR Sbjct: 11 VQVADSTFTVLKRYQQLKPI---GSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 67 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDKGQT 149 +L + ++ V+ ++ + DV++ MELMD +L + +D + Sbjct: 68 AYREL-VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHER- 125 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ + Sbjct: 126 -----MSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFM 179 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY------DSWGTP 263 T + Y APE I GY DIWS+G M EL + D W Sbjct: 180 MTPYVVTRYYRAPEVI----LGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKV 235 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 +QL +P SAEF+ ++ + RP YP + F Sbjct: 236 IEQLG------TP-------SAEFMAALQPTVRNYVENRPAYPGIAFEELF 273 >3A4O-X nrPDB Length = 286 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 130/283 (45%), Gaps = 23/283 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + ++ + LG G +G V M + + +AVK ++ S + L + ++ M+ Sbjct: 8 WEIPRESIKLVKRLGAGQFGEV-WMGYYNNSTKVAVKTLKPGTMSVQA--FLEEANL-MK 63 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 T+ V Y + RE ++I E M SL F K D+G + L + I + Sbjct: 64 TLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKS--DEGGKVLLPKLIDFSAQIAE 121 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAP 222 + ++ K + IHRD++ +NVL++ K+ DFG++ + D+ + P + AP Sbjct: 122 GMAYIERK-NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 180 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI---LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 E IN +++KSD+WS GI + E+ + +P + L Q P + Sbjct: 181 EAINFGC----FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENC 236 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHESK 320 D E D C K+ ++ERPT+ L F+T E + Sbjct: 237 PD----ELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQ 275 >5AMN-A nrPDB Length = 299 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 68/267 (25%), Positives = 129/267 (48%), Gaps = 26/267 (9%) Query: 59 LGRGAYGVVEK-----MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V K ++ +AVK ++ + E + LL + ++ ++ V+ P + Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV-LKQVNHPHVI 89 Query: 114 TFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPED---ILGKI---AVSIVKAL 166 YGA ++G + + +E SL F ++ G P++ +G + A I + + Sbjct: 90 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGM 149 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSVAKTIDAGCKP--YMAP 222 ++L +++ ++HRD+ N+L+ ++K+ DFG+S Y DS K G P +MA Sbjct: 150 QYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR-SQGRIPVKWMAI 207 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVEEPSPQLPAD 281 E + + Y+ +SD+WS G+ + E+ L PY G P ++L +++ D Sbjct: 208 ESLFDHI----YTTQSDVWSFGVLLWEIVTLGGNPYP--GIPPERLFNLLKTGHRMERPD 261 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPEL 308 S E QC K+ +RP + ++ Sbjct: 262 NCSEEMYRLMLQCWKQEPDKRPVFADI 288 >2X4F-A nrPDB Length = 373 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 67/286 (23%), Positives = 131/286 (45%), Gaps = 27/286 (9%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG G +G V K +G +A K I+ T ++++ + ++ + M +D + Y A Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIK-TRGMKDKEEVKNEISV-MNQLDHANLIQLYDA 154 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 + D+ + ME +D + + ++ID+ + E I + + H+H ++ ++H Sbjct: 155 FESKNDIVLVMEYVDGG--ELFDRIIDESYNLTELDTILFMKQICEGIRHMH-QMYILHL 211 Query: 179 DVKPSNVL-INA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 D+KP N+L +N Q+K+ DFG++ ++ G ++APE +N + S Sbjct: 212 DLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDF----VSF 267 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF---SAEFVDFTSQ 293 +D+WS+G+ L P+ G + + L ++F S E +F S+ Sbjct: 268 PTDMWSVGVIAYMLLSGLSPF--LGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISK 325 Query: 294 CLKKNSKERPTYPELMQHPFFTLH-----------ESKGTDVASFV 328 L K R + E ++HP+ + H +++G+D FV Sbjct: 326 LLIKEKSWRISASEALKHPWLSDHKLHSRLSAQKKKNRGSDAQDFV 371 >2XS0-A nrPDB Length = 386 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 83/326 (25%), Positives = 139/326 (42%), Gaps = 63/326 (19%) Query: 39 ISIGNQNFEV--KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + IG+ F V + +L+PI G GA G+V + +A+K++ R N KR Sbjct: 15 VEIGDSTFTVLKRYQNLKPI---GSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKR 71 Query: 96 LLMDLDISMRTVDCPFTVTFYG------ALFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 +L + M+ V+ + +L DV+I MELMD +L + + +D Sbjct: 72 AYREL-VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELD---- 126 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ S Sbjct: 127 --HERMSYLLYQMLCGIKHLHSA-GIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM 183 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL--AILRFP----YDSWGTP 263 + Y APE I GY DIWS+G M E+ + FP D W Sbjct: 184 MVPFVVTRYYRAPEVI----LGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKV 239 Query: 264 FQQL---------------KQVVEE-------------PSPQLPADK-----FSAEFVDF 290 +QL + VE P PAD +++ D Sbjct: 240 IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDL 299 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTL 316 S+ L ++ +R + E +QHP+ + Sbjct: 300 LSKMLVIDASKRISVDEALQHPYINV 325 >1CM8-A nrPDB Length = 367 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 85/339 (25%), Positives = 146/339 (43%), Gaps = 67/339 (19%) Query: 27 STPPRDLDSKACISIGNQNFEVKA--DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI 84 S+PP + +EV+A DL+P+ G GAYG V +G +A+K++ Sbjct: 2 SSPPPARSGFYRQEVTKTAWEVRAVYRDLQPV---GSGAYGAVCSAVDGRTGAKVAIKKL 58 Query: 85 RATVNSQE-QKRLLMDLDI--SMRTVDCPFTVTFYG---ALFREGDVWICMELMDTSLDK 138 S+ KR +L + MR + + + L D ++ M M T L K Sbjct: 59 YRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGK 118 Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 K + + ED + + ++K L ++H+ +IHRD+KP N+ +N ++K+ DF Sbjct: 119 LMKH-----EKLGEDRIQFLVYQMLKGLRYIHAA-GIIHRDLKPGNLAVNEDCELKILDF 172 Query: 199 GI--------SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 G+ +GY+V + Y APE I LN Y+ DIWS+G M E+ Sbjct: 173 GLARQADSEMTGYVV----------TRWYRAPEVI---LNWMRYTQTVDIWSVGCIMAEM 219 Query: 251 AI-------------LRFPYDSWGTPFQQLKQVVEEPS--------PQLPADKFSAEF-- 287 L+ GTP + Q ++ P+L F++ Sbjct: 220 ITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTN 279 Query: 288 -----VDFTSQCLKKNSKERPTYPELMQHPFF-TLHESK 320 V+ + L ++++R T E + HP+F +LH+++ Sbjct: 280 ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 >3NYO-A nrPDB Length = 576 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 125/271 (46%), Gaps = 29/271 (10%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ-KRLLMDLDISMRTVDCPFTVTFYG 117 LG+G +G V + +G++ A K++ + + + + ++ + V+ F V+ Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQT-IPEDILGKIAVSIVKALEHLHSKLSVI 176 A + + + + LM+ KF+ + GQ PE A I LE LH + ++ Sbjct: 252 AYETKDALCLVLTLMNGGDLKFH--IYHMGQAGFPEARAVFYAAEICCGLEDLHRE-RIV 308 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 +RD+KP N+L++ G +++ D G++ ++ + G YMAPE + E Y+ Sbjct: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER----YTF 364 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS--------PQLPADKFSAEFV 288 D W+LG + E+ + +PFQQ K+ ++ P+ +++FS + Sbjct: 365 SPDWWALGCLLYEMI-------AGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 Query: 289 DFTSQCLKKNSKER-----PTYPELMQHPFF 314 SQ L K+ ER + E+ +HP F Sbjct: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 >3LIJ-A nrPDB Length = 494 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 69/273 (25%), Positives = 133/273 (48%), Gaps = 31/273 (11%) Query: 54 EPIMELGRGAYGVV----EKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVD 108 + + +LG GAYG V +K+ HV A+K IR T V++ +LL ++ + ++ +D Sbjct: 40 QRVKKLGSGAYGEVLLCRDKVTHVER----AIKIIRKTSVSTSSNSKLLEEVAV-LKLLD 94 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + Y + + ++ ME + + ++I + + D I ++ + + Sbjct: 95 HPNIMKLYDFFEDKRNYYLVMECYKGG--ELFDEIIHRMKFNEVDA-AVIIKQVLSGVTY 151 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 LH K +++HRD+KP N+L+ + + +K+ DFG+S + G Y+APE + Sbjct: 152 LH-KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL 210 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE-----PSPQLPA 280 +K Y K D+WS+G+ + L P+ G Q++ + VE+ SP+ Sbjct: 211 -----RKKYDEKCDVWSIGVILFILLAGYPPFG--GQTDQEILRKVEKGKYTFDSPEWKN 263 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 A+ D Q L+ +S+ R + + ++HP+ Sbjct: 264 VSEGAK--DLIKQMLQFDSQRRISAQQALEHPW 294 >2HK5-A nrPDB Length = 270 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 125/266 (46%), Gaps = 22/266 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + L+ +LG G +G V + ++ AVK ++ S E L + ++ M+ Sbjct: 10 WEIPRESLKLEKKLGAGQFGEVWMATYNKHTKV-AVKTMKPGSMSVEA--FLAEANV-MK 65 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 T+ V + + +E ++I E M SL F K D+G P L + I + Sbjct: 66 TLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKS--DEGSKQPLPKLIDFSAQIAE 122 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAP 222 + + + + IHRD++ +N+L++A K+ DFG++ + D+ + P + AP Sbjct: 123 GMAFIEQR-NYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 181 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTP--FQQLKQVVEEPSPQLP 279 E I N +++KSD+WS GI ++E+ R PY P + L++ P P+ Sbjct: 182 EAI----NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE-- 235 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTY 305 E + +C K +ERPT+ Sbjct: 236 --NCPEELYNIMMRCWKNRPEERPTF 259 >4CFF-A nrPDB Length = 571 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 98/210 (46%), Gaps = 16/210 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V+ H +G +AVK +IR+ + KR + +L + P + Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH----PHII 96 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Y + D ++ ME + S + + + G+ + E ++ I+ A+++ H + Sbjct: 97 KLYQVISTPTDFFMVMEYV--SGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 153 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L G Sbjct: 154 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL-YAG 211 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTP 263 V DIWS G+ + L P+D P Sbjct: 212 PEV--DIWSCGVILYALLCGTLPFDDEHVP 239 >5YV8-A nrPDB Length = 298 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 8/157 (5%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA-GCKPYM 220 ++K +E+LH + +IHRD+KPSN+L+ G +K+ DFG+S S A + G +M Sbjct: 146 LIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFM 204 Query: 221 APERINPELNQKGYSVKS-DIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 APE ++ +K +S K+ D+W++G+T+ + P+ L ++ + + P Sbjct: 205 APESLSE--TRKIFSGKALDVWAMGVTLYCFVFGQCPF--MDERIMCLHSKIKSQALEFP 260 Query: 280 ADKFSAE-FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 AE D ++ L KN + R PE+ HP+ T Sbjct: 261 DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVT 297 >5EZV-A nrPDB Length = 560 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 98/210 (46%), Gaps = 16/210 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V+ H +G +AVK +IR+ + KR + +L + P + Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH----PHII 91 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Y + D ++ ME + S + + + G+ + E ++ I+ A+++ H + Sbjct: 92 KLYQVISTPTDFFMVMEYV--SGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 148 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L G Sbjct: 149 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL-YAG 206 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTP 263 V DIWS G+ + L P+D P Sbjct: 207 PEV--DIWSCGVILYALLCGTLPFDDEHVP 234 >4AW2-A nrPDB Length = 437 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 112/223 (50%), Gaps = 31/223 (13%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-------RA-TVNSQEQKRLLMDLDI 102 +D E + +GRGA+G V ++ + ++ A+K + RA T +E++ +L++ Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVN--- 130 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMEL-----MDTSLDKFYKQVIDKGQTIPEDILGK 157 D + T + A + ++++ M+ + T L KF + +PE++ Sbjct: 131 ----GDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR-------LPEEMARF 179 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAG 215 +V A++ +H +L +HRD+KP N+L++ G +++ DFG L++ +V ++ G Sbjct: 180 YLAEMVIAIDSVH-QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVG 238 Query: 216 CKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPY 257 Y++PE + KG Y + D WSLG+ M E+ P+ Sbjct: 239 TPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >6BDL-A nrPDB Length = 347 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 103/211 (48%), Gaps = 22/211 (10%) Query: 48 VKADDLEPIMELGRGAYGVVE--KMRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISM 104 +K D I LG G +G VE +++ S M + + R V++++Q+ + + I M Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI-M 89 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS-IV 163 + F V Y +++ ME + + + D+G ED + + +V Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGG--ELWTILRDRGSF--EDSTTRFYTACVV 145 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM--- 220 +A +LHSK +I+RD+KP N++++ G K+ DFG AK I G K + Sbjct: 146 EAFAYLHSK-GIIYRDLKPENLILDHRGYAKLVDFGF--------AKKIGFGKKTWTFCG 196 Query: 221 APERINPELN-QKGYSVKSDIWSLGITMIEL 250 PE + PE+ KG+ + +D WSLGI M EL Sbjct: 197 TPEYVAPEIILNKGHDISADYWSLGILMYEL 227 >4REW-A nrPDB Length = 540 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 99/210 (47%), Gaps = 16/210 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V+ +H +G +AVK +IR+ + +R + +L + P + Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH----PHII 69 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Y + D+++ ME + S + + + G+ + E ++ I+ +++ H + Sbjct: 70 KLYQVISTPSDIFMVMEYV--SGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHM 126 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L G Sbjct: 127 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRL-YAG 184 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTP 263 V DIWS G+ + L P+D P Sbjct: 185 PEV--DIWSSGVILYALLCGTLPFDDDHVP 212 >4YNZ-A nrPDB Length = 342 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 111/220 (50%), Gaps = 22/220 (10%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE-QKRLLMDLDIS---MRTVDCPFTVT 114 LG+G G+V+ H + Q +A+K VN ++ + +LM ++ ++ ++ P + Sbjct: 18 LGKGQTGLVKLGIHCVTCQKVAIK----IVNREKLSESVLMKVEREIAILKLIEHPHVLK 73 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + E ++ + L S + + ++ KG+ P++ K I+ AL+ HS S Sbjct: 74 LHDVY--ENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEA-RKFFRQIISALDFCHSH-S 129 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKG 233 + HRD+KP N+L++ +++ DFG++ V DS+ +T G Y PE I E K Sbjct: 130 ICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLET-SCGSPHYACPEVIRGE---KY 185 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 K+D+WS G+ + L + P+D L+Q++E+ Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDD-----DNLRQLLEK 220 >3PPZ-A nrPDB Length = 309 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/216 (27%), Positives = 108/216 (50%), Gaps = 17/216 (7%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVK-RIRATVNSQEQKRLLMDLDISMRTVDCP 110 DL ++G G++G V + G +AVK + +++ L ++ I M+ + P Sbjct: 38 DLNIKEKIGAGSFGTVHRAEW--HGSDVAVKILMEQDFHAERVNEFLREVAI-MKRLRHP 94 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--QTIPEDILGKIAVSIVKALEH 168 V F GA+ + ++ I E + S Y+ + G + + E +A + K + + Sbjct: 95 NIVLFMGAVTQPPNLSIVTEYL--SRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 169 LHSKLS-VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP-YMAPERIN 226 LH++ ++HRD+K N+L++ VK+CDFG+S + + A P +MAPE + Sbjct: 153 LHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLR 212 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262 E + + KSD++S G+ + ELA L+ P WG Sbjct: 213 DEPSNE----KSDVYSFGVILWELATLQQP---WGN 241 >6CCF-A nrPDB Length = 290 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 50/159 (31%), Positives = 87/159 (54%), Gaps = 12/159 (7%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-TIDAGCKPYM 220 ++ LE+LH + ++HRD+KPSN+L+ G VK+ DFG+S + A+ + AG +M Sbjct: 138 VILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFM 196 Query: 221 APERINPELNQKGYSVKS-DIWSLGITMIELAILRFPY-DSWGTPFQQLKQVVEEPS--P 276 APE I+ + + +S K+ D+W+ G+T+ + P+ D + +++ EP P Sbjct: 197 APEAISD--SGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH--RKIKNEPVVFP 252 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + P + S E D + L KN + R P++ HP+ T Sbjct: 253 EEP--EISEELKDLILKMLDKNPETRIGVPDIKLHPWVT 289 >4RED-A nrPDB Length = 351 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 98/210 (46%), Gaps = 16/210 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V+ +H +G +AVK +IR+ + +R + +L + P + Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH----PHII 77 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Y + D+++ ME + S + + + G+ + E ++ I+ +++ H + Sbjct: 78 KLYQVISTPSDIFMVMEYV--SGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHM 134 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L Sbjct: 135 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-- 191 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTP 263 + DIWS G+ + L P+D P Sbjct: 192 -GPEVDIWSSGVILYALLCGTLPFDDDHVP 220 >4CFH-A nrPDB Length = 493 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 119/263 (45%), Gaps = 23/263 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V+ +H +G +AVK +IR+ + +R + +L + P + Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH----PHII 96 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Y + D+++ ME + S + + + G+ + E ++ I+ +++ H + Sbjct: 97 KLYQVISTPSDIFMVMEYV--SGGELFDYICKNGR-LDEKESRRLFQQILSGVDYCHRHM 153 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L Sbjct: 154 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYA-- 210 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE--PSPQLPADKFSAEFVDFT 291 + DIWS G+ + L P+D P K++ + +PQ + + Sbjct: 211 -GPEVDIWSSGVILYALLCGTLPFDDDHVP-TLFKKICDGIFYTPQY----LNPSVISLL 264 Query: 292 SQCLKKNSKERPTYPELMQHPFF 314 L+ + +R T ++ +H +F Sbjct: 265 KHMLQVDPMKRATIKDIREHEWF 287 >5AIR-A nrPDB Length = 430 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/289 (24%), Positives = 133/289 (46%), Gaps = 43/289 (14%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT---- 114 +G G++GVV + + SG+++A+K++ Q+++ +L I MR +D V Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKVL-----QDKRFKNRELQI-MRKLDHCNIVRLRYF 125 Query: 115 FYGALFREGDVW--ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 FY + ++ +V+ + ++ + ++ + + QT+P + + ++L ++HS Sbjct: 126 FYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS- 184 Query: 173 LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 + HRD+KP N+L++ +K+CDFG + LV + Y APE I Sbjct: 185 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI---FGA 241 Query: 232 KGYSVKSDIWSLGITMIELAILR--FPYDS-----------WGTPF-QQLKQV----VEE 273 Y+ D+WS G + EL + + FP DS GTP +Q++++ E Sbjct: 242 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 301 Query: 274 PSPQLPADKFSAEF--------VDFTSQCLKKNSKERPTYPELMQHPFF 314 PQ+ A ++ F + S+ L+ R T E H FF Sbjct: 302 KFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 350 >4IDT-A nrPDB Length = 356 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 69/257 (26%), Positives = 116/257 (45%), Gaps = 28/257 (10%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 + LGRG++G V +M +G AVK++R V E+ ++ + P V Y Sbjct: 80 LRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEEL-------MACAGLTSPRIVPLY 132 Query: 117 GALFREGD-VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 GA+ REG V I MEL++ Q++ + +PED ++ LE+LHS+ + Sbjct: 133 GAV-REGPWVNIFMELLEGG---SLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSR-RI 187 Query: 176 IHRDVKPSNVLINALG-QVKMCDFGIS------GYLVDSVAKTIDAGCKPYMAPERINPE 228 +H DVK NVL+++ G +CDFG + G D + G + +MAPE + Sbjct: 188 LHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVV--- 244 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 + K D+WS M+ + P+ + LK E P P + Sbjct: 245 -LGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPP----PVREIPPSCA 299 Query: 289 DFTSQCLKKNSKERPTY 305 T+Q +++ ++ P + Sbjct: 300 PLTAQAIQEGLRKEPIH 316 >4JXF-A nrPDB Length = 266 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 130/271 (47%), Gaps = 16/271 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRT 106 K +D + LG+G++ V + + +G +A+K I +A + +R+ ++ I + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQ- 63 Query: 107 VDCPFTVTFYGALFREGDVWICMEL-MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P + Y V++ +E+ + ++++ K ++ + E+ I+ Sbjct: 64 LKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLK---NRVKPFSENEARHFMHQIITG 120 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 + +LHS ++HRD+ SN+L+ +K+ DFG++ L K C P I Sbjct: 121 MLYLHSH-GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTL-CG---TPNYI 175 Query: 226 NPEL-NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 +PE+ + + ++SD+WSLG L I R P+D+ T L +VV ++P+ S Sbjct: 176 SPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDT-DTVKNTLNKVV-LADYEMPS-FLS 232 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 E D Q L++N +R + ++ HPF + Sbjct: 233 IEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >2A1A-B nrPDB Length = 284 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/271 (25%), Positives = 128/271 (47%), Gaps = 27/271 (9%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-RLLMDLDIS--MRTVD 108 D + I +G G +G V K +H G+ +KR++ E++ + L LD + Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNG 71 Query: 109 C-------PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK--GQTIPEDILGKIA 159 C P T + + + ++I ME D +Q I+K G+ + + + ++ Sbjct: 72 CWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGT---LEQWIEKRRGEKLDKVLALELF 128 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 I K ++++HSK +I+RD+KPSN+ + QVK+ DFG+ L + +T G Y Sbjct: 129 EQITKGVDYIHSK-KLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRY 187 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 M+PE+I+ + Y + D+++LG+ + EL + T F+ K + + Sbjct: 188 MSPEQISSQ----DYGKEVDLYALGLILAELLHV------CDTAFETSK-FFTDLRDGII 236 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 +D F + + L K ++RP E+++ Sbjct: 237 SDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >5WNL-A nrPDB Length = 342 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/263 (23%), Positives = 124/263 (47%), Gaps = 22/263 (8%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL-LMDLDISMRTVDCPFTVTFY 116 ++G G +G V K+RHV +A+K +++ +++R+ L++ M + + Y Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWLAIK-CSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 117 GALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS-KLS 174 G + V + ME M+T SL+K + +P D+ +I + LH Sbjct: 86 GIC--QEPVGLVMEYMETGSLEKLLAS-----EPLPWDLRFRIVHETAVGMNFLHCMSPP 138 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGIS--GYLVDSVAKTIDA--GCKPYMAPERINPELN 230 ++H ++KP+N+L++A VK+ DFG++ + S ++D G Y+ PERI + Sbjct: 139 LLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREK-- 196 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-----DKFSA 285 + + K D++S I + + + P+ + +VV+ P+LP + A Sbjct: 197 SRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACA 256 Query: 286 EFVDFTSQCLKKNSKERPTYPEL 308 + +C + + RPT+ E+ Sbjct: 257 SLIGLMQRCWHADPQVRPTFQEI 279 >2VD5-A nrPDB Length = 412 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 73/293 (24%), Positives = 133/293 (45%), Gaps = 27/293 (9%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-------RATVNS- 90 I + + ++ DD E + +GRGA+ V ++ +GQ+ A+K + R V+ Sbjct: 49 IVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCF 108 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTI 150 +E++ +L++ D T F L+ + ++ +L+ T L KF G+ I Sbjct: 109 REERDVLVNGDRRWIT-QLHFAFQDENYLYLVMEYYVGGDLL-TLLSKF-------GERI 159 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVA 209 P ++ IV A++ +H +L +HRD+KP N+L++ G +++ DFG L D Sbjct: 160 PAEMARFYLAEIVMAIDSVH-RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTV 218 Query: 210 KTIDA-GCKPYMAPE---RINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTP 263 +++ A G Y++PE + Y + D W+LG+ E+ + P+ DS Sbjct: 219 RSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAET 278 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQ--CLKKNSKERPTYPELMQHPFF 314 + ++ E S L + E DF + C + R + HPFF Sbjct: 279 YGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFF 331 >3LM0-A nrPDB Length = 327 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 60/264 (22%), Positives = 120/264 (45%), Gaps = 15/264 (5%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE-QKRLLMDLDISMRTVDCPFTVTFY 116 ELGRG + VV + +GQ A K ++ Q+ + +L ++ + CP + + Sbjct: 36 ELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLH 95 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 ++ + +E + F + + + + E+ + ++ I++ + +LH +++ Sbjct: 96 EVYENTSEIILILEYAAGG-EIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQN-NIV 153 Query: 177 HRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 H D+KP N+L+++ LG +K+ DFG+S + + G Y+APE LN Sbjct: 154 HLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEI----LNYDP 209 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE---FVDF 290 + +D+W++GI L P+ G Q+ + + + + FS+ DF Sbjct: 210 ITTATDMWNIGIIAYMLLTHTSPF--VGEDNQETYLNISQVNVDYSEETFSSVSQLATDF 267 Query: 291 TSQCLKKNSKERPTYPELMQHPFF 314 L KN ++RPT + H + Sbjct: 268 IQSLLVKNPEKRPTAEICLSHSWL 291 >3DB8-A nrPDB Length = 317 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 65/260 (25%), Positives = 127/260 (48%), Gaps = 15/260 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM-RTVDCPFTVTFYG 117 LG+G + ++ + + ++ A K + ++ + ++ M +I++ +++D P V F+G Sbjct: 50 LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHG 109 Query: 118 ALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + V++ +E+ SL + +K+ K T PE ++ +++LH+ VI Sbjct: 110 FFEDDDFVYVVLEICRRRSLLELHKR--RKAVTEPE--ARYFMRQTIQGVQYLHNN-RVI 164 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 HRD+K N+ +N VK+ DFG++ + D K G Y+APE L +KG+S Sbjct: 165 HRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPE----VLCKKGHS 220 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 + DIWSLG + L + + P+++ ++ E S + ++ + + L Sbjct: 221 FEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALI---RRML 277 Query: 296 KKNSKERPTYPELMQHPFFT 315 + RP+ EL+ FFT Sbjct: 278 HADPTLRPSVAELLTDEFFT 297 >3SXS-A nrPDB Length = 268 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 74/271 (27%), Positives = 123/271 (45%), Gaps = 22/271 (8%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 + E+K +++ + ELG G +GVV K+ +AVK I+ S+++ +M Sbjct: 2 HMELKREEITLLKELGSGQFGVV-KLGKWKGQYDVAVKMIKEGSMSEDE---FFQEAQTM 57 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + P V FYG +E ++I E + Y + KG P +L ++ + + Sbjct: 58 MKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE-PSQLL-EMCYDVCE 115 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYMA 221 + L S IHRD+ N L++ VK+ DFG++ Y++D + G K + A Sbjct: 116 GMAFLESH-QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVS-SVGTKFPVKWSA 173 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLK--QVVEEPSPQL 278 PE + YS KSD+W+ GI M E+ L + PYD + LK Q P L Sbjct: 174 PEV----FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHL 229 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 +D C + ++RPT+ +L+ Sbjct: 230 ASDT----IYQIMYSCWHELPEKRPTFQQLL 256 >4TPT-A nrPDB Length = 303 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 97/213 (45%), Gaps = 31/213 (14%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG+G +G K+ H +G++M +K + + + QK L ++ + MR++D P + F G Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKV-MRSLDHPNVLKFIGV 65 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 L+++ + + E ++ K + + +D P + A I + +LHS + +IHR Sbjct: 66 LYKDKKLNLLTEYIEGGTLKDFLRSMD---PFPWQQKVRFAKGIASGMAYLHS-MCIIHR 121 Query: 179 DVKPSNVLINALGQVKMCDFGISGYLV---------------------DSVAKTIDAGCK 217 D+ N LI V + DFG+S +V D + G Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 +MAPE LN K Y DI+S GI + E+ Sbjct: 182 YWMAPEM----LNGKSYDETVDIFSFGIVLCEI 210 >5F9E-A nrPDB Length = 353 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 70/279 (25%), Positives = 124/279 (44%), Gaps = 29/279 (10%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 ++K +D E LG+G++G V + Q A+K ++ V +LMD D+ Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDV-------VLMDDDVECTM 67 Query: 107 VD---------CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 V+ PF + + +++ ME ++ ++ Q K Sbjct: 68 VEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATF--- 124 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGC 216 A I+ L+ LHSK +++RD+K N+L++ G +K+ DFG+ + AKT + G Sbjct: 125 YAAEIILGLQFLHSK-GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGT 183 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP 276 Y+APE + L QK Y+ D WS G+ + E+ I + P+ G ++L + +P Sbjct: 184 PDYIAPEIL---LGQK-YNHSVDWWSFGVLLYEMLIGQSPFH--GQDEEELFHSIRMDNP 237 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKER-PTYPELMQHPFF 314 P E D + + ++R ++ QHP F Sbjct: 238 FYPR-WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLF 275 >2PL0-A nrPDB Length = 289 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 129/282 (45%), Gaps = 22/282 (7%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +EV + L+ + LG G +G V M + +AVK ++ S L + ++ M+ Sbjct: 18 WEVPRETLKLVERLGAGQFGEV-WMGYYNGHTKVAVKSLKQ--GSMSPDAFLAEANL-MK 73 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + V Y + +E ++I E M+ SL F K G + + L +A I + Sbjct: 74 QLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLK--TPSGIKLTINKLLDMAAQIAE 130 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYMA 221 + + + + IHRD++ +N+L++ K+ DFG++ L++ T G K + A Sbjct: 131 GMAFIEER-NYIHRDLRAANILVSDTLSCKIADFGLAR-LIEDNEYTAREGAKFPIKWTA 188 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPA 280 PE I N +++KSD+WS GI + E+ R PY P ++ Q +E + Sbjct: 189 PEAI----NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNP--EVIQNLERGYRMVRP 242 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPEL--MQHPFFTLHESK 320 D E C K+ ++RPT+ L + FFT E + Sbjct: 243 DNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQ 284 >2R2P-A nrPDB Length = 295 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 28/265 (10%) Query: 59 LGRGAYGVVEKMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +G G +G V R G+ +A+K ++ ++++ L + I M D P + Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASI-MGQFDHPNIIHL 88 Query: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G + + V I E M+ SLD F K+ + GQ ++G + I +++L S + Sbjct: 89 EGVVTKSKPVMIVTEYMENGSLDTFLKK--NDGQFTVIQLVGMLR-GISAGMKYL-SDMG 144 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAPERINPELN 230 +HRD+ N+LIN+ K+ DFG+S L D A T G P + APE I Sbjct: 145 YVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI----A 200 Query: 231 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEE----PSPQLPADKFSA 285 + ++ SD+WS GI M E ++ PY W Q + + VEE PSP A Sbjct: 201 FRKFTSASDVWSYGIVMWEVVSYGERPY--WEMTNQDVIKAVEEGYRLPSPM----DCPA 254 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQ 310 C +K RP + E++ Sbjct: 255 ALYQLMLDCWQKERNSRPKFDEIVN 279 >4FG9-A nrPDB Length = 320 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 132/278 (47%), Gaps = 23/278 (8%) Query: 49 KADDLEPIME----LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS- 103 +A+D+ I + LG GA+ V + +++A+K I + E K M+ +I+ Sbjct: 12 QAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCI--AKEALEGKEGSMENEIAV 69 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + + P V G +++ M+L+ S + + ++++KG D ++ ++ Sbjct: 70 LHKIKHPNIVALDDIYESGGHLYLIMQLV--SGGELFDRIVEKGFYTERDA-SRLIFQVL 126 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 A+++LH L ++HRD+KP N+L +L ++ + DFG+S + G Y+ Sbjct: 127 DAVKYLHD-LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYV 185 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQ-LKQVVEEPSPQ 277 APE L QK YS D WS+G+ L P+ ++ F+Q LK E SP Sbjct: 186 APEV----LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPY 241 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 D S DF ++K+ ++R T + +QHP+ Sbjct: 242 W--DDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >2YAB-A nrPDB Length = 361 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 128/278 (46%), Gaps = 39/278 (14%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK---RLLMDLDIS-MRTVDCPFTV 113 ELG G + +V+K R +G A K I+ + ++ R ++ ++S +R V P + Sbjct: 19 ELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNII 78 Query: 114 TFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 T + DV + +EL+ L F Q +++ E+ I+ + +LH+K Sbjct: 79 TLHDVYENRTDVVLILELVSGGELFDFLAQ----KESLSEEEATSFIKQILDGVNYLHTK 134 Query: 173 LSVIHRDVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 + H D+KP N+++ + +K+ DFG++ + D V G ++APE +N E Sbjct: 135 -KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYE 193 Query: 229 LNQKGYSVKSDIWSLG-ITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK--FSA 285 +++D+WS+G IT I L S +PF L +E + A F Sbjct: 194 ----PLGLEADMWSIGVITYILL--------SGASPF--LGDTKQETLANITAVSYDFDE 239 Query: 286 EFV--------DFTSQCLKKNSKERPTYPELMQHPFFT 315 EF DF + L K +++R T E ++HP+ T Sbjct: 240 EFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5G6V-A nrPDB Length = 324 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 70/293 (23%), Positives = 125/293 (42%), Gaps = 52/293 (17%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIR------ATVNSQEQKRLLMDLDISMRTVDCPF 111 +LG G Y V K + + ++A+K IR A + + LL DL + Sbjct: 9 KLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHAN------- 61 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 VT + + E + + E +D L ++ + D G I + +++ L + H Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLDKDLKQY---LDDCGNIINMHNVKLFLFQLLRGLAYCHR 118 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV-AKTIDAGCKP--YMAPERINPE 228 + V+HRD+KP N+LIN G++K+ DFG++ S+ KT D Y P+ + Sbjct: 119 Q-KVLHRDLKPQNLLINERGELKLADFGLAR--AKSIPTKTYDNEVVTLWYRPPDIL--- 172 Query: 229 LNQKGYSVKSDIWSLGITMIELAI-------------LRFPYDSWGTPFQQL-------K 268 L YS + D+W +G E+A L F + GTP ++ + Sbjct: 173 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232 Query: 269 QVVEEPSPQLPAD-------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + P+ A+ + ++ D ++ L+ + R + + M+HPFF Sbjct: 233 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4LRM-A nrPDB Length = 334 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 74/274 (27%), Positives = 120/274 (43%), Gaps = 24/274 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K + + I LG GA+G V K +P G+ + A+K +R + + K +L D Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL-DEAYV 74 Query: 104 MRTVDCPFT--VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 M +VD P V + V + +LM V + I L V Sbjct: 75 MASVDNPGNPHVCRLLGICLTSTVQLITQLM--PFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKP-- 218 I K + +L + ++HRD+ NVL+ VK+ DFG++ L + + G P Sbjct: 133 IAKGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK 191 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPS 275 +MA E I + Y+ +SD+WS G+T+ EL PYD G P ++ ++E E Sbjct: 192 WMALESI----LHRIYTHQSDVWSYGVTVWELMTFGSKPYD--GIPASEISSILEKGERL 245 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 PQ P + +C ++ RP + EL+ Sbjct: 246 PQPPICTIDVYMI--MVKCWMIDADSRPKFRELI 277 >4B6L-A nrPDB Length = 281 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 62/261 (23%), Positives = 122/261 (46%), Gaps = 17/261 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG+G + + +G AVK I +++++L ++++ R + V F Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH-RDLQHRHIVRFS 75 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 +++I +EL K + T+ E + I+ L++LH + ++ Sbjct: 76 HHFEDADNIYIFLELCSR---KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR-GIL 131 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKPYMAPERINPELNQKGY 234 HRD+K N I ++K+ DFG++ L + KTI G Y+APE L ++G+ Sbjct: 132 HRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTI-CGTPNYVAPE----VLLRQGH 186 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 ++D+WSLG M L P+++ ++ + +++ LPA S + Sbjct: 187 GPEADVWSLGCVMYTLLCGSPPFET--ADLKETYRCIKQVHYTLPAS-LSLPARQLLAAI 243 Query: 295 LKKNSKERPTYPELMQHPFFT 315 L+ + ++RP+ ++++H FFT Sbjct: 244 LRASPRDRPSIDQILRHDFFT 264 >3DXN-A nrPDB Length = 287 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 73/284 (25%), Positives = 129/284 (45%), Gaps = 22/284 (7%) Query: 40 SIGNQN--FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRL 96 S G +N F+ +D + + +LG GAYG V + +G A+K I+ ++V + Sbjct: 8 SSGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGA 67 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 L+D ++ +D P + Y + + ++ ME+ + + ++I + Q E Sbjct: 68 LLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILR-QKFSEVDAA 124 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTID 213 I ++ +LH K +++HRD+KP N+L+ + + +K+ DFG+S + Sbjct: 125 VIMKQVLSGTTYLH-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKER 183 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ--LKQVV 271 G Y+APE + +K Y K D+WS G+ L IL Y +G Q LK+V Sbjct: 184 LGTAYYIAPEVL-----RKKYDEKCDVWSCGVI---LYILLCGYPPFGGQTDQEILKRVE 235 Query: 272 EEPSPQLPAD--KFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 + P D + S E L +R + E + HP+ Sbjct: 236 KGKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPW 279 >3TXO-A nrPDB Length = 353 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 12/229 (5%) Query: 35 SKACISIG-NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ 93 SK IG N + + D+ E I LG+G++G V R +G + AVK ++ V Q+ Sbjct: 6 SKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDD 65 Query: 94 --KRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 + + + I + PF + ++ ME ++ F+ I K + Sbjct: 66 DVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFH---IQKSRRFD 122 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAK 210 E A I+ AL LH K +I+RD+K NVL++ G K+ DFG+ + + V Sbjct: 123 EARARFYAAEIISALMFLHDK-GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTT 181 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 G Y+APE + L Y D W++G+ + E+ P+++ Sbjct: 182 ATFCGTPDYIAPEILQEML----YGPAVDWWAMGVLLYEMLCGHAPFEA 226 >2YZA-A nrPDB Length = 276 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 97/210 (46%), Gaps = 16/210 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V+ H +G +AVK +IR+ + KR + +L + P + Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH----PHII 74 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 Y + D ++ ME + S + + + G+ + E ++ I+ A+++ H + Sbjct: 75 KLYQVISTPTDFFMVMEYV--SGGELFDYICKHGR-VEEMEARRLFQQILSAVDYCHRHM 131 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 V+HRD+KP NVL++A K+ DFG+S + D G Y APE I+ L Sbjct: 132 -VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYA-- 188 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWGTP 263 + DIWS G+ + L P+D P Sbjct: 189 -GPEVDIWSCGVILYALLCGTLPFDDEHVP 217 >1FVR-A nrPDB Length = 327 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 69/285 (24%), Positives = 118/285 (41%), Gaps = 37/285 (12%) Query: 59 LGRGAYGVVEKMRHVPSGQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 +G G +G V K R G M A+KR++ + + + +L++ + P + Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 117 GALFREGDVWICME------LMD-------TSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 GA G +++ +E L+D D + T+ L A + Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 + +++L K IHRD+ N+L+ K+ DFG+S V KT+ +MA E Sbjct: 153 RGMDYLSQK-QFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIE 211 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-VEEPSPQ----- 277 +N + Y+ SD+WS G+ + E+ L GTP+ + + E PQ Sbjct: 212 SLNYSV----YTTNSDVWSYGVLLWEIVSLG------GTPYCGMTCAELYEKLPQGYRLE 261 Query: 278 --LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 L D E D QC ++ ERP++ +++ L E K Sbjct: 262 KPLNCDD---EVYDLMRQCWREKPYERPSFAQILVSLNRMLEERK 303 >1JPA-A nrPDB Length = 312 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 120/263 (45%), Gaps = 22/263 (8%) Query: 59 LGRGAYG-VVEKMRHVPSGQ--IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +G G +G V +P + +A+K +++ ++++ L + I M D P + Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASI-MGQFDHPNVIHL 99 Query: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G + + V I E M+ SLD F +Q + GQ ++G + I +++L + ++ Sbjct: 100 EGVVTKSTPVMIITEFMENGSLDSFLRQ--NDGQFTVIQLVGMLR-GIAAGMKYL-ADMN 155 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK---TIDAGCK---PYMAPERINPE 228 +HRD+ N+L+N+ K+ DFG+S +L D + T G K + APE I Sbjct: 156 YVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI--- 212 Query: 229 LNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 + ++ SD+WS GI M E ++ PY W Q + +E+ P + Sbjct: 213 -QYRKFTSASDVWSYGIVMWEVMSYGERPY--WDMTNQDVINAIEQDYRLPPPMDCPSAL 269 Query: 288 VDFTSQCLKKNSKERPTYPELMQ 310 C +K+ RP + +++ Sbjct: 270 HQLMLDCWQKDRNHRPKFGQIVN 292 >6GQK-A nrPDB Length = 328 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 72/280 (25%), Positives = 124/280 (44%), Gaps = 40/280 (14%) Query: 59 LGRGAYGVV-----EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG GA+G V + + + +AVK ++ + +S E++ L+ +L + + V Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIV 108 Query: 114 TFYGALFREGDVWICMELMDTS-LDKFYKQVIDK---GQTIPEDI---------LGKIAV 160 GA G + E L F ++ D+ + PED+ L + Sbjct: 109 NLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSY 168 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--- 217 + K + L SK + IHRD+ N+L+ K+CDFG++ + + + +D G Sbjct: 169 QVAKGMAFLASK-NCIHRDLAARNILLTHGNITKICDFGLARDIKND-SNYVDKGNARLP 226 Query: 218 -PYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTP-----FQQLKQV 270 +MAPE I + Y+ +SD+WS GI + EL L PY G P ++ +K+ Sbjct: 227 VKWMAPESIFNSV----YTFESDVWSYGIFLWELFSLGSSPYP--GMPVDSKFYKMIKEG 280 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 SP+ AE D C + +RPT+ +++Q Sbjct: 281 FRMSSPEYAP----AEMYDIMKTCWDADPDKRPTFKQIVQ 316 >3SOA-A nrPDB Length = 444 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/266 (23%), Positives = 127/266 (47%), Gaps = 19/266 (7%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 ELG+GA+ VV + V +GQ A I +++++ ++L + I R + P V + Sbjct: 18 ELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARIC-RLLKHPNIVRLH 76 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 ++ EG ++ +L+ + ++ ++ + + E I++A+ H H ++ V+ Sbjct: 77 DSISEEGHHYLIFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILEAVLHCH-QMGVV 132 Query: 177 HRDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQK 232 HR++KP N+L+ + VK+ DFG++ + AG Y++PE L + Sbjct: 133 HRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE----VLRKD 188 Query: 233 GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DKFSAEFVD 289 Y D+W+ G+ + L + P+ W +L Q ++ + P+ D + E D Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPF--WDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 246 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFT 315 ++ L N +R T E ++HP+ + Sbjct: 247 LINKMLTINPSKRITAAEALKHPWIS 272 >3DKO-A nrPDB Length = 318 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 82/312 (26%), Positives = 137/312 (43%), Gaps = 40/312 (12%) Query: 11 PGLK--IPKEAFEQPQTSSTP-PRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67 PG K I E +E P + ++LD+ +CI I +G G +G V Sbjct: 15 PGTKTYIDPETYEDPNRAVHQFAKELDA-SCIKIERV--------------IGAGEFGEV 59 Query: 68 EKMRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD 124 R G+ +A+K ++ ++++ L + I M D P V G + R Sbjct: 60 CSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASI-MGQFDHPNVVHLEGVVTRGKP 118 Query: 125 VWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPS 183 V I +E M+ +LD F ++ GQ ++G + I + +L + + +HRD+ Sbjct: 119 VMIVIEFMENGALDAFLRK--HDGQFTVIQLVGMLR-GIAAGMRYL-ADMGYVHRDLAAR 174 Query: 184 NVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSD 239 N+L+N+ K+ DFG+S + D T G P + APE I + ++ SD Sbjct: 175 NILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAI----QYRKFTSASD 230 Query: 240 IWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKK 297 +WS GI M E ++ PY W Q + + +EE +LPA A C +K Sbjct: 231 VWSYGIVMWEVMSYGERPY--WDMSNQDVIKAIEE-GYRLPAPMDCPAGLHQLMLDCWQK 287 Query: 298 NSKERPTYPELM 309 ERP + +++ Sbjct: 288 ERAERPKFEQIV 299 >3UTO-A nrPDB Length = 573 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 123/271 (45%), Gaps = 16/271 (5%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ELG GA+GVV ++ +G A K + T + +++ + ++ +M + P V + Sbjct: 164 ELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQ-TMSVLRHPTLVNLHD 221 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 A + ++ + E M S + +++V D+ + ED + + K L H+H + +H Sbjct: 222 AFEDDNEMVMIYEFM--SGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHEN-NYVH 278 Query: 178 RDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 D+KP N++ ++K+ DFG++ +L + + G + APE E GY Sbjct: 279 LDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVA--EGKPVGYY 336 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA---EFVDFTS 292 +D+WS+G+ L P+ G + + V+ + FS + DF Sbjct: 337 --TDMWSVGVLSYILLSGLSPFG--GENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR 392 Query: 293 QCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 + L + R T + ++HP+ T + G D Sbjct: 393 KLLLADPNTRMTIHQALEHPWLTPGNAPGRD 423 >4JG6-A nrPDB Length = 355 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 76/292 (26%), Positives = 127/292 (43%), Gaps = 57/292 (19%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +EVK D +G G+Y V ++ H + AVK I + ++ +++I +R Sbjct: 37 YEVKED-------IGVGSYSVCKRCIHKATNMEFAVKII-----DKSKRDPTEEIEILLR 84 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTS--LDKFYKQVIDKGQTIPEDILGKIAVSIV 163 P +T V++ ELM LDK +Q + E + +I Sbjct: 85 YGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQ-----KFFSEREASAVLFTIT 139 Query: 164 KALEHLHSKLSVIHRDVKPSNVL-INALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPY 219 K +E+LH++ V+HRD+KPSN+L ++ G +++CDFG AK + A Sbjct: 140 KTVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGF--------AKQLRAENGLL 190 Query: 220 MAP----ERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVE 272 M P + PE L ++GY DIWSLG+ + + P+ + TP E Sbjct: 191 MTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTP--------E 242 Query: 273 EPSPQLPADKFSAE----------FVDFTSQCLKKNSKERPTYPELMQHPFF 314 E ++ + KFS D S+ L + +R T +++HP+ Sbjct: 243 EILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >2VWV-A nrPDB Length = 302 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 120/262 (45%), Gaps = 22/262 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +G G +G V + R G+ +A+K ++ ++++ L + I M + P + Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASI-MGQFEHPNIIRL 82 Query: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G + V I E M+ +LD F + ++ GQ ++G + I + +L +++S Sbjct: 83 EGVVTNSMPVMILTEFMENGALDSFLR--LNDGQFTVIQLVGMLR-GIASGMRYL-AEMS 138 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA---KTIDAGCK---PYMAPERINPE 228 +HRD+ N+L+N+ K+ DFG+S +L ++ + +T G K + APE I Sbjct: 139 YVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAI--- 195 Query: 229 LNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 + ++ SD WS GI M E ++ PY W Q + +E+ P Sbjct: 196 -AFRKFTSASDAWSYGIVMWEVMSFGERPY--WDMSNQDVINAIEQDYRLPPPPDCPTSL 252 Query: 288 VDFTSQCLKKNSKERPTYPELM 309 C +K+ RP +P+++ Sbjct: 253 HQLMLDCWQKDRNARPRFPQVV 274 >3BHH-A nrPDB Length = 295 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 130/271 (47%), Gaps = 19/271 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDC 109 D+ + ++G+GA+ VV + + +G A K I +++++ ++L + I R + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARIC-RLLKH 62 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V + ++ EG ++ +L+ + ++ ++ + + E I++A+ H Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILEAVLHC 119 Query: 170 HSKLSVIHRDVKPSNVLINAL---GQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERI 225 H ++ V+HRD+KP N+L+ + VK+ DFG++ + D A AG Y++PE + Sbjct: 120 H-QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 178 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---DK 282 E Y DIW+ G+ + L + P+ W +L Q ++ + P+ D Sbjct: 179 RKE----AYGKPVDIWACGVILYILLVGYPPF--WDEDQHKLYQQIKAGAYDFPSPEWDT 232 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 + E + +Q L N +R T E ++HP+ Sbjct: 233 VTPEAKNLINQMLTINPAKRITAHEALKHPW 263 >4G3E-A nrPDB Length = 352 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/211 (30%), Positives = 106/211 (50%), Gaps = 26/211 (12%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +GRG++G V +M+ +G AVK++R V E+ ++ + P V YGA Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEEL-------VACAGLSSPRIVPLYGA 134 Query: 119 LFREGD-VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + REG V I MEL++ SL + KQ+ +PED ++ LE+LH++ ++ Sbjct: 135 V-REGPWVNIFMELLEGGSLGQLIKQM----GCLPEDRALYYLGQALEGLEYLHTR-RIL 188 Query: 177 HRDVKPSNVLINALG-QVKMCDFGISGYLV-DSVAKTIDA-----GCKPYMAPERINPEL 229 H DVK NVL+++ G + +CDFG + L D + K++ G + +MAPE + Sbjct: 189 HGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVV---- 244 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSW 260 K K DIWS M+ + P+ + Sbjct: 245 MGKPCDAKVDIWSSCCMMLHMLNGCHPWTQY 275 >1KOA-A nrPDB Length = 491 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 123/271 (45%), Gaps = 16/271 (5%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ELG GA+GVV ++ +G A K + T + +++ + ++ +M + P V + Sbjct: 58 ELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQ-TMSVLRHPTLVNLHD 115 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 A + ++ + E M S + +++V D+ + ED + + K L H+H + +H Sbjct: 116 AFEDDNEMVMIYEFM--SGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHEN-NYVH 172 Query: 178 RDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 D+KP N++ ++K+ DFG++ +L + + G + APE E GY Sbjct: 173 LDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVA--EGKPVGYY 230 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA---EFVDFTS 292 +D+WS+G+ L P+ G + + V+ + FS + DF Sbjct: 231 --TDMWSVGVLSYILLSGLSPFG--GENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR 286 Query: 293 QCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 + L + R T + ++HP+ T + G D Sbjct: 287 KLLLADPNTRMTIHQALEHPWLTPGNAPGRD 317 >1AD5-A nrPDB Length = 438 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 84/323 (26%), Positives = 143/323 (44%), Gaps = 47/323 (14%) Query: 7 KKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGV 66 KK N GL + P SS P + + A +E+ + L+ +LG G +G Sbjct: 149 KKGNDGLC---QKLSVPCMSSKPQKPWEKDA--------WEIPRESLKLEKKLGAGQFGE 197 Query: 67 VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVW 126 V + ++ AVK ++ S E L + ++ M+T+ V + + +E ++ Sbjct: 198 VWMATYNKHTKV-AVKTMKPGSMSVEA--FLAEANV-MKTLQHDKLVKLHAVVTKE-PIY 252 Query: 127 ICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 I E M SL F K D+G P L + I + + + + + IHRD++ +N+ Sbjct: 253 IITEFMAKGSLLDFLKS--DEGSKQPLPKLIDFSAQIAEGMAFIEQR-NYIHRDLRAANI 309 Query: 186 LINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWS 242 L++A K+ DFG++ G K + APE I N +++KSD+WS Sbjct: 310 LVSASLVCKIADFGLA-----------RVGAKFPIKWTAPEAI----NFGSFTIKSDVWS 354 Query: 243 LGITMIELAIL-RFPYDSWGTP--FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNS 299 GI ++E+ R PY P + L++ P P+ E + +C K Sbjct: 355 FGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE----NCPEELYNIMMRCWKNRP 410 Query: 300 KERPT--YPELMQHPFFTLHESK 320 +ERPT Y + + F+T ES+ Sbjct: 411 EERPTFEYIQSVLDDFYTATESQ 433 >3UIU-A nrPDB Length = 306 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/286 (23%), Positives = 130/286 (45%), Gaps = 44/286 (15%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL----------- 100 D + I +G G +G V K +H G+ ++R++ N+++ +R + L Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK--YNNEKAEREVKALAKLDHVNIVHY 70 Query: 101 --------------DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK 146 D S+ + D + + + ++I ME D +Q I+K Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGT---LEQWIEK 127 Query: 147 --GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 G+ + + + ++ I K ++++HSK +IHRD+KPSN+ + QVK+ DFG+ L Sbjct: 128 RRGEKLDKVLALELFEQITKGVDYIHSK-KLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 205 VDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF 264 + +T G YM+PE+I+ + Y + D+++LG+ + EL + T F Sbjct: 187 KNDGKRTRSKGTLRYMSPEQISSQ----DYGKEVDLYALGLILAELLHV------CDTAF 236 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + K + + +D F + + L K ++RP E+++ Sbjct: 237 ETSK-FFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >1ZXE-A nrPDB Length = 303 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 120/272 (44%), Gaps = 51/272 (18%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 A D E I LG+GA+G V K R+ + A+K+IR T +E+ ++ + + +++ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHT---EEKLSTILSEVMLLASLNH 61 Query: 110 PFTVTFYGALF-------------REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 + V +Y A ++ ++I ME + Y + + D Sbjct: 62 QYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENR--TLYDLIHSENLNQQRDEYW 119 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--- 213 ++ I++AL ++HS+ +IHR++KP N+ I+ VK+ DFG L +V +++D Sbjct: 120 RLFRQILEALSYIHSQ-GIIHRNLKPMNIFIDESRNVKIGDFG----LAKNVHRSLDILK 174 Query: 214 ----------------AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 G Y+A E ++ Y+ K D++SLGI E+ +P+ Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLD---GTGHYNEKIDMYSLGIIFFEMI---YPF 228 Query: 258 DSWG---TPFQQLKQVVEEPSPQLPADKFSAE 286 + ++L+ V E P +K E Sbjct: 229 STGMERVNILKKLRSVSIEFPPDFDDNKMKVE 260 >1NY3-A nrPDB Length = 400 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 126/274 (45%), Gaps = 36/274 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 115 LG G G V ++ + + + A+K + Q+ + ++++ R CP V Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 123 Query: 116 YGALFR-EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 173 Y L+ + I ME +D + + ++ D+G Q E +I SI +A+++LHS + Sbjct: 124 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-I 180 Query: 174 SVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 ++ HRDVKP N+L NA+ +K+ DFG + + T Y+APE + PE Sbjct: 181 NIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFP--YDSWG---TPFQQLKQVV---EEPSPQLPA 280 Y D+WSLG+ M L + +P Y + G +P + + + E P+P+ Sbjct: 239 ----KYDKSCDMWSLGVIMYIL-LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW-- 291 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + S E LK +R T E M HP+ Sbjct: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >3KN6-A nrPDB Length = 325 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 20/207 (9%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC-PFTVTFYG 117 LG G++ + K H S Q AVK I + + QK + +++ + P V + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEI-----TALKLCEGHPNIVKLHE 73 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + ++ MEL++ + +++ I K + E I +V A+ H+H + V+H Sbjct: 74 VFHDQLHTFLVMELLNGG--ELFER-IKKKKHFSETEASYIMRKLVSAVSHMHD-VGVVH 129 Query: 178 RDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAPERINPELNQK 232 RD+KP N+L N ++K+ DFG + L + + C Y APE LNQ Sbjct: 130 RDLKPENLLFTDENDNLEIKIIDFGFA-RLKPPDNQPLKTPCFTLHYAAPEL----LNQN 184 Query: 233 GYSVKSDIWSLGITMIELAILRFPYDS 259 GY D+WSLG+ + + + P+ S Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQS 211 >5J0A-A nrPDB Length = 300 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/286 (23%), Positives = 129/286 (45%), Gaps = 32/286 (11%) Query: 55 PIME-LGRGAYGVVEKMRHVPSG---QIMAVKRIRATVN----SQEQKRLLMDLDISMRT 106 P M+ LG G V M+ P G AVK+I N S QKRL+ + I +++ Sbjct: 12 PFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKI-LKS 70 Query: 107 VDCPFTVTFYGALFREGDVWICMELM---DTSLDKFYKQVIDKGQT-IPEDILGKIAVSI 162 + P + Y A D +C+ + + SL+ ++ Q P I+ K+A+++ Sbjct: 71 LHHP-NIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 + L++LH + ++H D+K SNV+I +K+CD G+S L +++ T C Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 222 PERINPELNQKGY-SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE------- 273 P + + + G + K+DI++ G+T+ E+ L P+ + + +E Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEA 249 Query: 274 ---------PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P D+ + ++ S C ++ K+RP+ +++ Sbjct: 250 YYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >5HI2-A nrPDB Length = 283 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 47/158 (29%), Positives = 82/158 (51%), Gaps = 8/158 (5%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDSVAKTIDA 214 IA + +++LH+K S+IHRD+K +N+ ++ VK+ DFG++ S + Sbjct: 116 IARQTARGMDYLHAK-SIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLS 174 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G +MAPE I + + YS +SD+++ GI + EL + PY + Q ++ V Sbjct: 175 GSILWMAPEVIRMQ-DSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGS 233 Query: 275 -SPQLPADKFSA--EFVDFTSQCLKKNSKERPTYPELM 309 SP L + + ++CLKK ERP++P ++ Sbjct: 234 LSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRIL 271 >2OZA-A nrPDB Length = 356 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 126/274 (45%), Gaps = 36/274 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 115 LG G G V ++ + + + A+K + Q+ + ++++ R CP V Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 79 Query: 116 YGALFR-EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 173 Y L+ + I ME +D + + ++ D+G Q E +I SI +A+++LHS + Sbjct: 80 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-I 136 Query: 174 SVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 ++ HRDVKP N+L NA+ +K+ DFG + + T Y+APE + PE Sbjct: 137 NIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 194 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFP--YDSWG---TPFQQLKQVV---EEPSPQLPA 280 Y D+WSLG+ M L + +P Y + G +P + + + E P+P+ Sbjct: 195 ----KYDKSCDMWSLGVIMYIL-LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW-- 247 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + S E LK +R T E M HP+ Sbjct: 248 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >1K9A-A nrPDB Length = 450 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 123/273 (45%), Gaps = 26/273 (9%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 + + +L+ + +G+G +G V M G +AVK I+ +Q L + + M Sbjct: 187 GWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQA---FLAEASV-M 240 Query: 105 RTVDCPFTVTFYGALFRE-GDVWICMELM-DTSLDKFYKQVIDKGQTI-PEDILGKIAVS 161 + V G + E G ++I E M SL + + +G+++ D L K ++ Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS---RGRSVLGGDCLLKFSLD 297 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--Y 219 + +A+E+L + +HRD+ NVL++ K+ DFG L + T D G P + Sbjct: 298 VCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKW 352 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIEL-AILRFPYDSWGTPFQQLKQVVEEPSPQL 278 APE L +K +S KSD+WS GI + E+ + R PY P + + VE+ Sbjct: 353 TAPE----ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKMD 406 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 D D C ++ RPT+ +L + Sbjct: 407 APDGCPPAVYDVMKNCWHLDAATRPTFLQLREQ 439 >3CJF-A nrPDB Length = 309 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 73/287 (25%), Positives = 127/287 (44%), Gaps = 29/287 (10%) Query: 46 FEVKADDLEPIMELGRGAYG-VVEK----MRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 +E D L LGRGA+G V+E + + + +AVK ++ E + L+ +L Sbjct: 22 WEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 81 Query: 101 DISMRTVDCPFTVTFYGALFREGD-VWICMEL---------MDTSLDKF--YKQVIDKGQ 148 I + V GA + G + + +E + + ++F YK + Sbjct: 82 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFL 141 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--- 205 T+ I + + K +E L S+ IHRD+ N+L++ VK+CDFG++ + Sbjct: 142 TLEHLIC--YSFQVAKGMEFLASR-KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 198 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPF 264 D V K +MAPE I + Y+++SD+WS G+ + E+ L PY Sbjct: 199 DYVRKGDARLPLKWMAPETI----FDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDE 254 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + +++ E + P D + E C +RPT+ EL++H Sbjct: 255 EFCRRLKEGTRMRAP-DYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >3ZUT-A nrPDB Length = 362 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/272 (25%), Positives = 122/272 (44%), Gaps = 19/272 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVD 108 +D E + ++G G +GV MR S +++AVK I R + KR + I+ R++ Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI----INHRSLR 73 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V F + + I ME S + ++++ + G+ ED ++ + + Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEY--ASGGELFERICNAGR-FSEDEARFFFQQLISGVSY 130 Query: 169 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 H+ + V HRD+K N L++ ++K+C FG S V G Y+APE Sbjct: 131 CHA-MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEV-- 187 Query: 227 PELNQKGYSVK-SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 283 L +K Y K +D+WS G+T+ + + +P++ P K + + Q + Sbjct: 188 --LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 Query: 284 -SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E S+ + +R + PE+ H +F Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >3HZT-A nrPDB Length = 467 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 73/285 (25%), Positives = 127/285 (44%), Gaps = 21/285 (7%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVD 108 +D + + +LG GAYG V + +G A+K I+ ++V + L+D ++ +D Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + Y + + ++ ME+ + + ++I + Q E I ++ + Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILR-QKFSEVDAAVIMKQVLSGTTY 119 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 LH K +++HRD+KP N+L+ + + +K+ DFG+S + G Y+APE + Sbjct: 120 LH-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 178 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ--LKQVVEEPSPQLPAD-- 281 +K Y K D+WS G+ L IL Y +G Q LK+V + P D Sbjct: 179 -----RKKYDEKCDVWSCGVI---LYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWT 230 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT-LHESKGTDVA 325 + S E L +R + E + HP+ K TDV Sbjct: 231 QVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVG 275 >4MYG-A nrPDB Length = 372 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 123/299 (41%), Gaps = 62/299 (20%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-----EQKRLLMDLDISMRTVDCPFT 112 +G GAYG V SG+ +A+K++ S+ + LL+ + V Sbjct: 50 HVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 113 V-TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V T +L D ++ M M T L K G E+ + + ++K L+++HS Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQTDLQKIM------GMEFSEEKIQYLVYQMLKGLKYIHS 163 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGI--------SGYLVDSVAKTIDAGCKPYMAPE 223 V+HRD+KP N+ +N ++K+ DFG+ +GY+V + Y APE Sbjct: 164 A-GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVV----------TRWYRAPE 212 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGTPFQQLKQV 270 I L+ Y+ DIWS+G M E+ + + G P + Q Sbjct: 213 VI---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQK 269 Query: 271 VEEPS--------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 314 + + + PQ P F+ F D + L+ + +R T + + HPFF Sbjct: 270 LNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 328 >2Y6O-A nrPDB Length = 291 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 120/261 (45%), Gaps = 20/261 (7%) Query: 59 LGRGAYGVVEKMR-HVPSGQ--IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +G G +G V R VP + +A+K ++A ++++ L + I M D P + Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASI-MGQFDHPNIIHL 80 Query: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G + + V I E M+ SLD F ++ + G+ ++G + I +++L S +S Sbjct: 81 EGVVTKCKPVMIITEYMENGSLDAFLRK--NDGRFTVIQLVGMLR-GIGSGMKYL-SDMS 136 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAPERINPELN 230 +HRD+ N+L+N+ K+ DFG+S L D A T G P + APE I Sbjct: 137 YVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI----A 192 Query: 231 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 + ++ SD+WS GI M E ++ PY W Q + + +EE P Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPY--WDMSNQDVIKAIEEGYRLPPPMDCPIALHQ 250 Query: 290 FTSQCLKKNSKERPTYPELMQ 310 C +K +RP + +++ Sbjct: 251 LMLDCWQKERSDRPKFGQIVN 271 >2XYN-A nrPDB Length = 292 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 127/298 (42%), Gaps = 34/298 (11%) Query: 39 ISIGNQN--------FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS 90 + +G +N +E++ D+ +LG G YG V +AVK ++ ++ Sbjct: 12 VDLGTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE--DT 69 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID----- 145 E + L + + M+ + P V G E +I E M Y ++D Sbjct: 70 MEVEEFLKEAAV-MKEIKHPNLVQLLGVCTLEPPFYIVTEYMP------YGNLLDYLREC 122 Query: 146 KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV 205 + + +L +A I A+E+L K + IHRD+ N L+ VK+ DFG+S L+ Sbjct: 123 NREEVTAVVLLYMATQISSAMEYLEKK-NFIHRDLAARNCLVGENHVVKVADFGLSR-LM 180 Query: 206 DSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWG 261 T AG K + APE L +S+KSD+W+ G+ + E+A PY G Sbjct: 181 TGDTYTAHAGAKFPIKWTAPE----SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP--G 234 Query: 262 TPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 Q+ ++E+ + + + C K + +RP++ E Q H+S Sbjct: 235 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 292 >3KUL-B nrPDB Length = 325 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 84/312 (26%), Positives = 134/312 (42%), Gaps = 41/312 (13%) Query: 14 KIPKEAF-EQPQTSSTPPRDLDSKACISIGNQNF--EVKADDLEPIMELGRGAYGVVEKM 70 K+P+ F +P T P R ++F E++A + +G G G V Sbjct: 19 KLPEPQFYAEPHTYEEPGR----------AGRSFTREIEASRIHIEKIIGSGDSGEVCYG 68 Query: 71 RHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWI 127 R GQ +A+K ++A ++++ L + I M D P + G + R I Sbjct: 69 RLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASI-MGQFDHPNIIRLEGVVTRGRLAMI 127 Query: 128 CMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 E M+ SLD F + GQ ++G + + + +L S L +HRD+ NVL Sbjct: 128 VTEYMENGSLDTFLR--THDGQFTIMQLVGMLR-GVGAGMRYL-SDLGYVHRDLAARNVL 183 Query: 187 INALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWS 242 +++ K+ DFG+S L D A T G P + APE I + +S SD+WS Sbjct: 184 VDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAI----AFRTFSSASDVWS 239 Query: 243 LGITMIE-LAILRFPYDSWGTPFQQLKQVVEE----PSPQLPADKFSAEFVDFTSQCLKK 297 G+ M E LA PY W + + VEE P+P +D C K Sbjct: 240 FGVVMWEVLAYGERPY--WNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLD----CWHK 293 Query: 298 NSKERPTYPELM 309 + +RP + +++ Sbjct: 294 DRAQRPRFSQIV 305 >2A27-A nrPDB Length = 321 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 126/279 (45%), Gaps = 41/279 (14%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRI-----RATVNSQEQKRLLMDLDISMRTVDCPFT 112 ELG G + +V+K R +G A K I RA+ ++ + ++ I +R V Sbjct: 19 ELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI-LRQVLHHNV 77 Query: 113 VTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 +T + DV + +EL+ L F Q +++ E+ I+ + +LH+ Sbjct: 78 ITLHDVYENRTDVVLILELVSGGELFDFLAQ----KESLSEEEATSFIKQILDGVNYLHT 133 Query: 172 KLSVIHRDVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 K + H D+KP N+++ + +K+ DFG++ + D V G ++APE +N Sbjct: 134 K-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNY 192 Query: 228 ELNQKGYSVKSDIWSLG-ITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK--FS 284 E +++D+WS+G IT I L S +PF L +E + A F Sbjct: 193 E----PLGLEADMWSIGVITYILL--------SGASPF--LGDTKQETLANITAVSYDFD 238 Query: 285 AEFV--------DFTSQCLKKNSKERPTYPELMQHPFFT 315 EF DF + L K +++R T E ++HP+ T Sbjct: 239 EEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5U6B-A nrPDB Length = 307 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 67/266 (25%), Positives = 120/266 (45%), Gaps = 20/266 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG G +G V + + I+ AVK ++ + ++ + + + M+ D P + Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 117 GALFREGD-------VWICMELMDTSLDKF--YKQVIDKGQTIPEDILGKIAVSIVKALE 167 G F+ + V I + L F Y ++ D+ +P +L K I +E Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 +L +K IHRD+ N ++N V + DFG+S + + G M + I Sbjct: 151 YLSTK-RFIHRDLAARNCMLNENMSVCVADFGLSKKIYN--GDYYRQGRIAKMPVKWIAI 207 Query: 228 E-LNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSP-QLPADKFS 284 E L + Y+ KSD+WS G+TM E+A + PY G ++ + + + + PAD Sbjct: 208 ESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP--GVENSEIYDYLRQGNRLKQPADCLD 265 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQ 310 + S+C + N ++RP++ EL + Sbjct: 266 GLYA-LMSRCWELNPQDRPSFTELRE 290 >4RA4-A nrPDB Length = 355 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 126/281 (44%), Gaps = 31/281 (11%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE--------QKRLLMD 99 VK D +M LG+G++G V + ++ A+K ++ V Q+ +KR+L Sbjct: 17 VKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 LD PF + ++ ME ++ ++ Q + K + P+ + Sbjct: 77 LDKP------PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKE-PQAVFYAAE 129 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKTIDAGCKP 218 +SI L LH K +I+RD+K NV++++ G +K+ DFG+ +++D V G Sbjct: 130 ISI--GLFFLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPD 186 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Y+APE I + Y D W+ G+ + E+ + P+D G +L Q + E + Sbjct: 187 YIAPEII----AYQPYGKSVDWWAYGVLLYEMLAGQPPFD--GEDEDELFQSIMEHNVSY 240 Query: 279 PADKFSAEFVDFTSQCLKKNSKER-PTYPE----LMQHPFF 314 P S E V + K+ +R PE + +H FF Sbjct: 241 PK-SLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFF 280 >1V0B-A nrPDB Length = 288 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 67/285 (23%), Positives = 125/285 (43%), Gaps = 37/285 (12%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ++G G YGVV K ++ G+ A+K+IR + + ++ + V Y Sbjct: 9 KIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYD 67 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK-IAVSIVKALEHLHSKLSVI 176 + + + + E +D L K+++D + E + K + ++ + + H + V+ Sbjct: 68 VIHTKKRLVLVFEHLDQDL----KKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR-RVL 122 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-TIDAGCKPYMAPERINPELNQKGYS 235 HRD+KP N+LIN G++K+ DFG++ V K T + Y AP+ + + K YS Sbjct: 123 HRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVL---MGSKKYS 179 Query: 236 VKSDIWSLGITMIEL--AILRFPYDSWGTPFQQLKQVVEEPSPQ---------------- 277 DIWS+G E+ FP S ++ +++ P+ + Sbjct: 180 TTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFT 239 Query: 278 ----LPADKFSAEF----VDFTSQCLKKNSKERPTYPELMQHPFF 314 LP + F +D S+ LK + +R T + ++H +F Sbjct: 240 VYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYF 284 >3N9X-A nrPDB Length = 432 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 104/221 (47%), Gaps = 38/221 (17%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +GRG+YG V + + +A+K++ R + + KR+L ++ I R + + + Y Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNR-LKSDYIIRLYD 92 Query: 118 A-----LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 L + +++I +E+ D+ L K +K I + E+ + I +++ +H Sbjct: 93 LIIPDDLLKFDELYIVLEIADSDLKKLFKTPI----FLTEEHIKTILYNLLLGENFIHES 148 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGIS--------GYLVDSVAKTIDAG--------- 215 +IHRD+KP+N L+N VK+CDFG++ +V+ + + + G Sbjct: 149 -GIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQ 207 Query: 216 ------CKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 + Y APE I L Q+ Y+ DIWS G EL Sbjct: 208 LTSHVVTRWYRAPELI---LLQENYTKSIDIWSTGCIFAEL 245 >3QGY-A nrPDB Length = 286 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 64/277 (23%), Positives = 128/277 (46%), Gaps = 24/277 (8%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 G+ + + +L + E+G G +G+V + + + +A+K I+ S + + + + Sbjct: 18 GSLHMVIDPSELTFVQEIGSGQFGLVH-LGYWLNKDKVAIKTIKE--GSMSEDDFIEEAE 74 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 + M+ + P V YG + + + E M+ Y + +G E +LG + + Sbjct: 75 VMMK-LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT-QRGLFAAETLLG-MCLD 131 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---P 218 + + + +L + VIHRD+ N L+ +K+ DFG++ +++D T G K Sbjct: 132 VCEGMAYLE-EACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD-QYTSSTGTKFPVK 189 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIEL-AILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + +PE + YS KSD+WS G+ M E+ + + PY++ + +VVE+ S Sbjct: 190 WASPEV----FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN-----RSNSEVVEDISTG 240 Query: 278 LPADK---FSAEFVDFTSQCLKKNSKERPTYPELMQH 311 K S + C K+ ++RP + L++ Sbjct: 241 FRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQ 277 >4XLV-A nrPDB Length = 328 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 71/293 (24%), Positives = 131/293 (44%), Gaps = 34/293 (11%) Query: 46 FEVKADDLEPIMELGRGAYGVVEK--MRHVPSGQI---MAVKRIRATVNSQEQKRLLMDL 100 +EV + + + ELG+G++G+V + R + G+ +AVK + + + +E+ L + Sbjct: 34 WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEA 93 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIP-------E 152 + M+ C V G + + + MELM L + + + + + P + Sbjct: 94 SV-MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ 152 Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSVAK 210 +++ ++A I + +L++K +HRD+ N ++ VK+ DFG++ Y D K Sbjct: 153 EMI-QMAAEIADGMAYLNAK-KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRK 210 Query: 211 TIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQL 267 G P +MAPE L ++ SD+WS G+ + E+ L PY G +Q+ Sbjct: 211 G-GKGLLPVRWMAPE----SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ--GLSNEQV 263 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ------HPFF 314 + V + D D C + N RPT+ E++ HP F Sbjct: 264 LKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >4AF3-A nrPDB Length = 292 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 73/282 (25%), Positives = 132/282 (46%), Gaps = 17/282 (6%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE- 92 +S I ++F + DD E LG+G +G V R S I+A+K + + +E Sbjct: 8 NSSGTPDILTRHFTI--DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG 65 Query: 93 -QKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 + +L +++I + P + Y + +++ +E + YK+ + K T Sbjct: 66 VEHQLRREIEIQAH-LHHPNILRLYNYFYDRRRIYLILEYAPRG--ELYKE-LQKSCTFD 121 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 E I + AL + H K VIHRD+KP N+L+ G++K+ DFG S + KT Sbjct: 122 EQRTATIMEELADALMYCHGK-KVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKT 180 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 + G Y+ PE I ++ + K D+W +G+ EL + P++S + + +++V Sbjct: 181 M-CGTLDYLPPEMIEGRMHNE----KVDLWCIGVLCYELLVGNPPFES-ASHNETYRRIV 234 Query: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 + + PA + D S+ L+ N ER ++ HP+ Sbjct: 235 -KVDLKFPASVPTGA-QDLISKLLRHNPSERLPLAQVSAHPW 274 >3E3P-A nrPDB Length = 360 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 98/200 (49%), Gaps = 11/200 (5%) Query: 60 GRGAYGVVEKMRHVPSGQIMAVKR-IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 G+G +G V+ + +G +A+K+ I+ + +++ DL + FY Sbjct: 32 GQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIVQLQSYFYTL 91 Query: 119 LFREG-DVW--ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV-SIVKALEHLH-SKL 173 R+ D++ + ME + +L + + + Q P IL K+ + +++++ LH + Sbjct: 92 GERDRRDIYLNVVMEYVPDTLHRCCRNYYRR-QVAPPPILIKVFLFQLIRSIGCLHLPSV 150 Query: 174 SVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQK 232 +V HRD+KP NVL+N A G +K+CDFG + L S + Y APE I + Sbjct: 151 NVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRYYRAPELI---FGNQ 207 Query: 233 GYSVKSDIWSLGITMIELAI 252 Y+ DIWS+G E+ + Sbjct: 208 HYTTAVDIWSVGCIFAEMML 227 >2BRG-A nrPDB Length = 297 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 64/279 (22%), Positives = 130/279 (46%), Gaps = 19/279 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQE--QKRLLMDLDISMRT 106 +D + + LG GAYG V+ + + + +AVK + + V+ E +K + ++ ++ Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V V FYG REG++ + + F + D G +PE + ++ + Sbjct: 67 V-----VKFYGHR-REGNIQYLFLEYCSGGELFDRIEPDIG--MPEPDAQRFFHQLMAGV 118 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKTIDAGCK--PYMAPE 223 +LH + + HRD+KP N+L++ +K+ DFG++ + ++ + ++ C PY+APE Sbjct: 119 VYLHG-IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPE 177 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF 283 + ++ ++ D+WS GI + + P+D Q+ E+ + P K Sbjct: 178 LLK---RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKI 234 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + + + L +N R T P++ + ++ KG Sbjct: 235 DSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGA 273 >4B8L-A nrPDB Length = 286 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 116/265 (43%), Gaps = 15/265 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT-VDC 109 DD + LG+G +G V R + IMA+K + + +E + +I +++ + Sbjct: 15 DDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRH 74 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P + Y +++ +E + YK++ G+ E + AL + Sbjct: 75 PNILRMYNYFHDRKRIYLMLEFAPRG--ELYKELQKHGR-FDEQRSATFMEELADALHYC 131 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 H + VIHRD+KP N+L+ G++K+ DFG S + S+ + G Y+ PE I Sbjct: 132 HER-KVIHRDIKPENLLMGYKGELKIADFGWSVH-APSLRRRTMCGTLDYLPPEMI---- 185 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-VEEPSPQLPADKFSAEFV 288 K + K D+W G+ E + P+DS + V V+ P +D Sbjct: 186 EGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSK---- 241 Query: 289 DFTSQCLKKNSKERPTYPELMQHPF 313 D S+ L+ + +R +M+HP+ Sbjct: 242 DLISKLLRYHPPQRLPLKGVMEHPW 266 >3KA0-A nrPDB Length = 320 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 126/274 (45%), Gaps = 36/274 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 115 LG G G V ++ + + + A+K + Q+ + ++++ R CP V Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 77 Query: 116 YGALFR-EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 173 Y L+ + I ME +D + + ++ D+G Q E +I SI +A+++LHS + Sbjct: 78 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-I 134 Query: 174 SVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 ++ HRDVKP N+L NA+ +K+ DFG + + T Y+APE + PE Sbjct: 135 NIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPE 192 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFP--YDSWG---TPFQQLKQVV---EEPSPQLPA 280 Y D+WSLG+ M L + +P Y + G +P + + + E P+P+ Sbjct: 193 ----KYDKSCDMWSLGVIMYIL-LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW-- 245 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + S E LK +R T E M HP+ Sbjct: 246 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >2V7O-A nrPDB Length = 336 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 65/291 (22%), Positives = 133/291 (45%), Gaps = 27/291 (9%) Query: 39 ISIGNQNFEVKA--------DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN 89 + +G +N ++ DD + ELG+GA+ VV + Q A K I ++ Sbjct: 11 VDLGTENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLS 70 Query: 90 SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 +++ ++L + I R + P V + ++ EG ++ +L+ + ++ ++ + + Sbjct: 71 ARDHQKLEREARIC-RLLKHPNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAR-EY 126 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL---GQVKMCDFGISGYLVD 206 E I++++ H+H ++HRD+KP N+L+ + VK+ DFG++ + Sbjct: 127 YSEADASHCIHQILESVNHIHQH-DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG 185 Query: 207 SVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 AG Y++PE L + Y DIW+ G+ + L + P+ W Sbjct: 186 EQQAWFGFAGTPGYLSPE----VLRKDPYGKPVDIWACGVILYILLVGYPPF--WDEDQH 239 Query: 266 QLKQVVEEPSPQLPA---DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 +L Q ++ + P+ D + E + +Q L N +R T + ++HP+ Sbjct: 240 KLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPW 290 >3DTC-A nrPDB Length = 271 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 94/220 (42%), Gaps = 40/220 (18%) Query: 110 PFTVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + G +E ++ + ME L++ + G+ IP DIL AV I + + + Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGPLNR-----VLSGKRIPPDILVNWAVQIARGMNY 120 Query: 169 LHSK--LSVIHRDVKPSNVLI----------NALGQVKMCDFGISGYLVDSVAKTIDAGC 216 LH + + +IHRD+K SN+LI N + +K+ DFG++ K AG Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKI--LKITDFGLAREW-HRTTKMSAAGA 177 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD-------SWGTPFQQLKQ 269 +MAPE I + KG SD+WS G+ + EL P+ ++G +L Sbjct: 178 YAWMAPEVIRASMFSKG----SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL 233 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + P+ F C + RP++ ++ Sbjct: 234 PIPSTCPE--------PFAKLMEDCWNPDPHSRPSFTNIL 265 >4Y83-A nrPDB Length = 332 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 50/159 (31%), Positives = 83/159 (52%), Gaps = 19/159 (11%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYM 220 ++K L+ LHSK VIH D+KPSN++ + V + DFG+S + + V D G + YM Sbjct: 174 VLKGLDFLHSK-KVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYM 231 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELA------ILRFPYDSWGTPFQQLKQVVEEP 274 +PE I +G+S K+DI+SLG T+I + + R+P + + ++ + Sbjct: 232 SPEVIL----CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSA----YPSYLYIIHKQ 283 Query: 275 SPQLP--ADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 +P L AD S + L++N RP +L++H Sbjct: 284 APPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >4UY9-A nrPDB Length = 323 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 69/275 (25%), Positives = 113/275 (41%), Gaps = 55/275 (20%) Query: 66 VVEKMRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD 124 V+ RH P I ++ +R QE K M + P + G +E + Sbjct: 36 AVKAARHDPDEDISQTIENVR-----QEAKLFAM--------LKHPNIIALRGVCLKEPN 82 Query: 125 VWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK--LSVIHRDVK 181 + + ME L++ + G+ IP DIL AV I + + +LH + + +IHRD+K Sbjct: 83 LCLVMEFARGGPLNR-----VLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLK 137 Query: 182 PSNVLI----------NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 SN+LI N + +K+ DFG++ K AG +MAPE I + Sbjct: 138 SSNILILQKVENGDLSNKI--LKITDFGLAREW-HRTTKMSAAGTYAWMAPEVIRASMFS 194 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYD-------SWGTPFQQLKQVVEEPSPQLPADKFS 284 KG SD+WS G+ + EL P+ ++G +L + P+ Sbjct: 195 KG----SDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPE------- 243 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 F C + RP++ ++ T+ ES Sbjct: 244 -PFAKLMEDCWNPDPHSRPSFTNILDQ-LTTIEES 276 >5HVK-A nrPDB Length = 315 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 98/205 (47%), Gaps = 20/205 (9%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG+G +G K+ H +G++M +K + + + Q+ L ++ + MR ++ P + F G Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKV-MRCLEHPNVLKFIGV 79 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 L+++ + E + + + +D + + A I + +LHS +++IHR Sbjct: 80 LYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRV--SFAKDIASGMAYLHS-MNIIHR 136 Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER------------IN 226 ++ N L+ V + DFG++ +VD KT G + P+R + Sbjct: 137 NLNSHNCLVRENKNVVVADFGLARLMVDE--KTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194 Query: 227 PEL-NQKGYSVKSDIWSLGITMIEL 250 PE+ N + Y K D++S GI + E+ Sbjct: 195 PEMINGRSYDEKVDVFSFGIVLCEI 219 >2BDW-A nrPDB Length = 362 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 70/283 (24%), Positives = 132/283 (46%), Gaps = 32/283 (11%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA-TVNSQEQKRLLMDLDISMRTVD 108 +D+ + ELG+GA+ VV + H +G A K I +++++ ++L + I R + Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARIC-RKLQ 86 Query: 109 CPFTVTFYGALFREGDVWICMELM-------DTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 P V + ++ E ++ +L+ D +FY + D I + Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEA-DASHCIQQ--------- 136 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKP 218 I++++ + HS ++HR++KP N+L+ + + VK+ DFG++ + DS A AG Sbjct: 137 ILESIAYCHSN-GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG 195 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQ-VVEEPS 275 Y++PE L + YS DIW+ G+ + L + P+ + + Q+K + PS Sbjct: 196 YLSPE----VLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPS 251 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 P+ D + E L N K+R T + ++ P+ E Sbjct: 252 PEW--DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRE 292 >1ZWS-A nrPDB Length = 288 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 68/271 (25%), Positives = 124/271 (45%), Gaps = 25/271 (9%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRI-----RATVNSQEQKRLLMDLDISMRTVDCPFT 112 ELG G + +V+K R +G A K I RA+ ++ + ++ I +R V Sbjct: 19 ELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI-LRQVLHHNV 77 Query: 113 VTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 +T + DV + +EL+ L F Q +++ E+ I+ + +LH+ Sbjct: 78 ITLHDVYENRTDVVLILELVSGGELFDFLAQ----KESLSEEEATSFIKQILDGVNYLHT 133 Query: 172 KLSVIHRDVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 K + H D+KP N+++ + +K+ DFG++ + D V G ++APE +N Sbjct: 134 K-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNY 192 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS--A 285 E +++D+WS+G+ L P+ G Q+ + S + FS + Sbjct: 193 E----PLGLEADMWSIGVITYILLSGASPF--LGDTKQETLANITSVSYDFDEEFFSHTS 246 Query: 286 EFV-DFTSQCLKKNSKERPTYPELMQHPFFT 315 E DF + L K +++R T E ++HP+ T Sbjct: 247 ELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5FG8-A nrPDB Length = 285 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 70/284 (24%), Positives = 132/284 (46%), Gaps = 33/284 (11%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVD 108 +D+ + ELG+GA+ +V++ +G A K I + +++ ++L + I R + Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARIC-RKLH 71 Query: 109 CPFTVTFYGALFREGDVWICMELM-------DTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 P V + ++ E ++ +L+ D +FY + D I + Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEA-DASHCIQQ--------- 121 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLV-DSVAKTIDAGCK 217 I++++ H H V+HRD+KP N+L+ + + VK+ DFG++ + D A AG Sbjct: 122 ILESVNHCHQN-GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTP 180 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQ-VVEEP 274 Y++PE L ++ Y DIW+ G+ + L + P+ + + Q+K + P Sbjct: 181 GYLSPEV----LKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYP 236 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 SP+ D + E + +Q L N +R T E ++HP+ E Sbjct: 237 SPEW--DTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRE 278 >3ORZ-A nrPDB Length = 316 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 63/266 (23%), Positives = 115/266 (43%), Gaps = 21/266 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG G++ V R + + + A+K + R + + + + D+ M +D PF V Y Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDV-MSRLDHPFFVKLY 103 Query: 117 GALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ++ + + L K+ +++ + E IV ALE+LH K + Sbjct: 104 FCFQDDEKLYFGLSYAKNGELLKYIRKI----GSFDETCTRFYTAEIVSALEYLHGK-GI 158 Query: 176 IHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID---AGCKPYMAPERINPELNQK 232 IHRD+KP N+L+N +++ DFG + L + G Y++PE L +K Sbjct: 159 IHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPEL----LTEK 214 Query: 233 GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV----EEPSPQLPADKFSAEFV 288 SD+W+LG + +L P+ + G + ++++ + P P + E + Sbjct: 215 SACKSSDLWALGCIIYQLVAGLPPFRA-GNEYLIFQKIIKLEYDFPEKFFPKARDLVEKL 273 Query: 289 DFTSQCLKKNSKERPTYPELMQHPFF 314 + +E Y L HPFF Sbjct: 274 LVLDATKRLGCEEMEGYGPLKAHPFF 299 >4XUF-A nrPDB Length = 297 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 127/294 (43%), Gaps = 39/294 (13%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-----MAVKRIRATVNSQEQKRLLMDL 100 +E ++LE LG GA+G V + +AVK ++ +S E++ L+ +L Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 63 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMEL---------MDTSLDKFYKQVI------- 144 + + V GA G +++ E + + +KF + I Sbjct: 64 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 145 -----DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 D ED+L A + K +E L K S +HRD+ NVL+ VK+CDFG Sbjct: 124 LEEEEDLNVLTFEDLLC-FAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFG 181 Query: 200 ISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF- 255 ++ ++ + + +MAPE L + Y++KSD+WS GI + E+ L Sbjct: 182 LARDIMSDSNYVVRGNARLPVKWMAPE----SLFEGIYTIKSDVWSYGILLWEIFSLGVN 237 Query: 256 PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQ-CLKKNSKERPTYPEL 308 PY G P + + ++ ++ E + Q C +S++RP++P L Sbjct: 238 PYP--GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >4F0G-A nrPDB Length = 287 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/269 (21%), Positives = 123/269 (45%), Gaps = 24/269 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD------ISM 104 +++E ++G+G +G+V K R V ++A+K + +S+ + ++ M Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSL-ILGDSEGETEMIEKFQEFQREVFIM 77 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 ++ P V YG + + ME + Y +++DK I + ++ + I Sbjct: 78 SNLNHPNIVKLYGLMHNPPR--MVMEFVPCG--DLYHRLLDKAHPIKWSVKLRLMLDIAL 133 Query: 165 ALEHLHSKL-SVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVDSVAKTIDAGCKP 218 +E++ ++ ++HRD++ N+ + +L + K+ DFG+S V SV+ + G Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSVSGLL--GNFQ 191 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS--P 276 +MAPE I E ++ Y+ K+D +S + + + P+D + + ++ E P Sbjct: 192 WMAPETIGAE--EESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRP 249 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTY 305 +P D + C + K+RP + Sbjct: 250 TIPED-CPPRLRNVIELCWSGDPKKRPHF 277 >3IO7-A nrPDB Length = 313 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 70/284 (24%), Positives = 130/284 (45%), Gaps = 41/284 (14%) Query: 53 LEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ + +LG+G +G VE R+ P +G+++AVK+++ + + + +++I ++++ Sbjct: 30 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIEI-LKSLQ 87 Query: 109 CPFTVTFYGALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V + G + G ++ + ME + + Y Q + I L + I K + Sbjct: 88 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--KHKERIDHIKLLQYTSQICKGM 145 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAP 222 E+L +K IHRD+ N+L+ +VK+ DFG++ L K + G P + AP Sbjct: 146 EYLGTK-RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 204 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSPQ--- 277 E L + +SV SD+WS G+ + EL F Y S P + ++ + + Q Sbjct: 205 E----SLTESKFSVASDVWSFGVVLYEL----FTYIEKSKSPPAEFMRMIGNDKQGQMIV 256 Query: 278 ------------LPA-DKFSAEFVDFTSQCLKKNSKERPTYPEL 308 LP D E ++C N +RP++ +L Sbjct: 257 FHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >5X02-A nrPDB Length = 347 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 73/294 (24%), Positives = 127/294 (43%), Gaps = 39/294 (13%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-----MAVKRIRATVNSQEQKRLLMDL 100 +E ++LE LG GA+G V + +AVK ++ +S E++ L+ +L Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 102 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMEL---------MDTSLDKFYKQVI------- 144 + + V GA G +++ E + + +KF + I Sbjct: 103 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 162 Query: 145 -----DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 D ED+L A + K +E L K S +HRD+ NVL+ VK+CDFG Sbjct: 163 LEEEEDLNVLTFEDLLC-FAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFG 220 Query: 200 ISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF- 255 ++ ++ + + +MAPE L + Y++KSD+WS GI + E+ L Sbjct: 221 LARDIMSDSNYVVRGNARLPVKWMAPE----SLFEGIYTIKSDVWSYGILLWEIFSLGVN 276 Query: 256 PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQ-CLKKNSKERPTYPEL 308 PY G P + + ++ ++ E + Q C +S++RP++P L Sbjct: 277 PYP--GIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >3KK8-A nrPDB Length = 284 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 71/285 (24%), Positives = 132/285 (46%), Gaps = 36/285 (12%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA-TVNSQEQKRLLMDLDISMRTVD 108 +D+ + ELG+GA+ VV + H +G A K I +++++ ++L + I R + Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARIC-RKLQ 63 Query: 109 CPFTVTFYGALFREGDVWICMELM-------DTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 P V + ++ E ++ +L+ D +FY + D I + Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEA-DASHCIQQ--------- 113 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKP 218 I++++ + HS ++HR++KP N+L+ + + VK+ DFG++ + DS A AG Sbjct: 114 ILESIAYCHSN-GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG 172 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP----FQQLKQ-VVEE 273 Y++PE L + YS DIW+ G+ + L + P+ W + Q+K + Sbjct: 173 YLSPEV----LKKDPYSKPVDIWACGVILYILLVGYPPF--WDEDQHRLYAQIKAGAYDY 226 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 PSP+ D + E L N K+R T + ++ P+ E Sbjct: 227 PSPEW--DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRE 269 >6BXI-A nrPDB Length = 333 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 66/255 (25%), Positives = 118/255 (46%), Gaps = 40/255 (15%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQ-KRLLMDLDISMRTVD 108 +D E + +GRGA+G V ++ +G + A+K +R A + +EQ + + DI + D Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDI-LVEAD 64 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + V + + + ++++ ME + ++ K T+ E+ V A++ Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGD---MMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-----------------VDSVAKT 211 +H +L IHRD+KP N+L+++ G VK+ DFG+ L D + Sbjct: 122 IH-QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 212 IDAGCKPYM--------------APERINPEL-NQKGYSVKSDIWSLGITMIELAILRFP 256 +++ K P+ I PE+ Q GY+ D WSLG+ M E+ I P Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPP 240 Query: 257 YDSWGTPFQQLKQVV 271 + S TP + K+V+ Sbjct: 241 FCS-ETPQETYKKVM 254 >2W1I-A nrPDB Length = 326 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 70/284 (24%), Positives = 130/284 (45%), Gaps = 41/284 (14%) Query: 53 LEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ + +LG+G +G VE R+ P +G+++AVK+++ + + + +++I ++++ Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIEI-LKSLQ 100 Query: 109 CPFTVTFYGALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V + G + G ++ + ME + + Y Q + I L + I K + Sbjct: 101 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ--KHKERIDHIKLLQYTSQICKGM 158 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAP 222 E+L +K IHRD+ N+L+ +VK+ DFG++ L K + G P + AP Sbjct: 159 EYLGTK-RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 217 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSPQ--- 277 E L + +SV SD+WS G+ + EL F Y S P + ++ + + Q Sbjct: 218 E----SLTESKFSVASDVWSFGVVLYEL----FTYIEKSKSPPAEFMRMIGNDKQGQMIV 269 Query: 278 ------------LPA-DKFSAEFVDFTSQCLKKNSKERPTYPEL 308 LP D E ++C N +RP++ +L Sbjct: 270 FHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >2JC6-A nrPDB Length = 334 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 137/296 (46%), Gaps = 31/296 (10%) Query: 43 NQNFEVKADDLEPIME----LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98 + +++ +A+D++ I E LG GA+ V +G++ AVK I ++ + Sbjct: 10 SSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIEN 69 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 ++ + +R + V +++ M+L+ S + + ++++KG +D + Sbjct: 70 EIAV-LRKIKHENIVALEDIYESPNHLYLVMQLV--SGGELFDRIVEKGFYTEKDA-STL 125 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAG 215 ++ A+ +LH ++ ++HRD+KP N+L + ++ + DFG+S + G Sbjct: 126 IRQVLDAVYYLH-RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 184 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP--YDSWGTP-FQQ-LKQVV 271 Y+APE L QK YS D WS+G+ L + +P YD + F+Q LK Sbjct: 185 TPGYVAPEV----LAQKPYSKAVDCWSIGVIAYIL-LCGYPPFYDENDSKLFEQILKAEY 239 Query: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF--------TLHES 319 E SP D S DF ++K+ +R T + +HP+ +HES Sbjct: 240 EFDSPYW--DDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHES 293 >2W4O-A nrPDB Length = 349 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 71/280 (25%), Positives = 127/280 (45%), Gaps = 17/280 (6%) Query: 41 IGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 I N + +D E ELGRGA +V + + + + A+K ++ TV+ +K + ++ Sbjct: 43 IDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVD---KKIVRTEI 99 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + +R + P + ++ + +EL+ + + ++++KG D + Sbjct: 100 GVLLR-LSHPNIIKLKEIFETPTEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVK- 155 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTIDAGCK 217 I++A+ +LH ++HRD+KP N+L +K+ DFG+S + V G Sbjct: 156 QILEAVAYLHEN-GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTP 214 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLG-ITMIELAILRFPYDSWGTPFQQLKQVVEEPSP 276 Y APE L Y + D+WS+G IT I L YD G F + + E Sbjct: 215 GYCAPEI----LRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYF 270 Query: 277 QLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P D+ S D + + + K+R T + +QHP+ T Sbjct: 271 ISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >4P5Q-A nrPDB Length = 361 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 70/272 (25%), Positives = 123/272 (45%), Gaps = 20/272 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMR-HVPSGQ--IMAVKRIRATVNSQEQKRLLMDLDIS 103 E+ A ++ +G G +G V R +PS + +A+K ++ ++++ L + I Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASI- 87 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSI 162 M D P + G + + V I E M+ SLD F ++ Q ++G + I Sbjct: 88 MGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRK--HDAQFTVIQLVGMLR-GI 144 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP-- 218 +++L S + +HRD+ N+LIN+ K+ DFG+S L D A T G P Sbjct: 145 ASGMKYL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIR 203 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + +PE I + ++ SD+WS GI + E ++ PY W Q + + V+E Sbjct: 204 WTSPEAI----AYRKFTSASDVWSYGIVLWEVMSYGERPY--WEMSNQDVIKAVDEGYRL 257 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 P A C +K+ RP + +++ Sbjct: 258 PPPMDCPAALYQLMLDCWQKDRNNRPKFEQIV 289 >4LQP-A nrPDB Length = 508 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 78/329 (23%), Positives = 139/329 (42%), Gaps = 71/329 (21%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQ-KRLLMDLDISMRTVD 108 +D + +G+GA+G V ++ +G+I A+K + ++ + ++Q + + D+ + D Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV-LAGSD 160 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P+ V+ Y + +++ ME + ++ + Q ED+ + A+E Sbjct: 161 SPWVVSLYYSFQDAQYLYLIMEFLPGGD---LMTMLIRWQLFTEDVTRFYMAECILAIET 217 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GY------------------------ 203 +H KL IHR +KP N+LI+ G +K+ DFG+S G+ Sbjct: 218 IH-KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISK 276 Query: 204 ------------------LVDSVAKTID--------AGCKPYMA------PERINPELN- 230 +VDS++ T+ + MA P+ I PE+ Sbjct: 277 PGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFL 336 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-EPSPQLPAD-KFSAEFV 288 +GY + D WSLG M E I P+ S TP + ++++ E + Q P D S E Sbjct: 337 YQGYGQECDWWSLGAIMYECLIGWPPFCS-ETPQETYRKIMNFEQTLQFPDDIHISYEAE 395 Query: 289 DFTSQCLKKNSKERPTY---PELMQHPFF 314 D + L + + E+ HPFF Sbjct: 396 DLIRRLLTHADQRLGRHGGADEIKSHPFF 424 >5L6P-A nrPDB Length = 298 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/263 (24%), Positives = 119/263 (45%), Gaps = 22/263 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +G G +G V + R G+ +A+K ++ ++++ L + I M D P + Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASI-MGQFDHPNIIRL 85 Query: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G + + V I E M+ +LD F + ++ GQ ++G + I +++L S+++ Sbjct: 86 EGVVTKSRPVMILTEFMENCALDSFLR--LNDGQFTVIQLVGMLR-GIAAGMKYL-SEMN 141 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK---TIDAGCK---PYMAPERINPE 228 +HRD+ N+L+N+ K+ DFG+S +L D + T G K + APE I Sbjct: 142 YVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAI--- 198 Query: 229 LNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 + ++ SD+WS GI M E ++ PY W Q + VE+ P Sbjct: 199 -AYRKFTSASDVWSYGIVMWEVMSYGERPY--WDMSNQDVINAVEQDYRLPPPMDCPTAL 255 Query: 288 VDFTSQCLKKNSKERPTYPELMQ 310 C ++ RP + +++ Sbjct: 256 HQLMLDCWVRDRNLRPKFSQIVN 278 >4NIF-A nrPDB Length = 333 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 75/280 (26%), Positives = 122/280 (43%), Gaps = 50/280 (17%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G G+Y ++ H + AVK I + + +++I +R P +T Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-----EIEILLRYGQHPNIITLKDV 70 Query: 119 LFREGDVWICMELMDTS--LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 V++ ELM LDK +Q + E + +I K +E+LHS+ V+ Sbjct: 71 YDDGKHVYLVTELMRGGELLDKILRQ-----KFFSEREASFVLHTIGKTVEYLHSQ-GVV 124 Query: 177 HRDVKPSNVL-INALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAP----ERINPE 228 HRD+KPSN+L ++ G +++CDFG AK + A M P + PE Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGF--------AKQLRAENGLLMTPCYTANFVAPE 176 Query: 229 -LNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEEPSPQLPADKF-- 283 L ++GY DIWSLGI + + P+ + TP EE ++ + KF Sbjct: 177 VLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTP--------EEILTRIGSGKFTL 228 Query: 284 --------SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 S D S+ L + +R T +++QHP+ T Sbjct: 229 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVT 268 >1U59-A nrPDB Length = 287 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 74/275 (26%), Positives = 131/275 (47%), Gaps = 31/275 (11%) Query: 57 MELGRGAYGVVEK-MRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 +ELG G +G V + + + QI +A+K ++ + + ++ + I M +D P+ V Sbjct: 16 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVR 74 Query: 115 FYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G E + + ME+ L KF ++ K + IP + ++ + +++L K Sbjct: 75 LIGVCQAEA-LMLVMEMAGGGPLHKF---LVGKREEIPVSNVAELLHQVSMGMKYLEEK- 129 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKP--YMAPERINPEL 229 + +HRD+ NVL+ K+ DFG+S L DS AG P + APE IN Sbjct: 130 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN--- 186 Query: 230 NQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTP----FQQLKQVVEEPSPQLPADKFS 284 + +S +SD+WS G+TM E L+ + PY P F + + +E P P+ P + ++ Sbjct: 187 -FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP-PECPPELYA 244 Query: 285 AEFVDFTSQCLKKNSKERP---TYPELMQHPFFTL 316 S C ++RP T + M+ +++L Sbjct: 245 -----LMSDCWIYKWEDRPDFLTVEQRMRACYYSL 274 >3UDB-A nrPDB Length = 317 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/272 (24%), Positives = 122/272 (44%), Gaps = 19/272 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVD 108 +D E + ++G G +GV MR + +++AVK I R + KR + I+ R++ Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREI----INHRSLR 73 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V F + + I ME S + ++++ + G+ ED ++ + + Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEY--ASGGELFERICNAGR-FSEDEARFFFQQLISGVSY 130 Query: 169 LHSKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 H+ + V HRD+K N L++ ++K+ DFG S V G Y+APE Sbjct: 131 AHA-MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEV-- 187 Query: 227 PELNQKGYSVK-SDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 283 L +K Y K +D+WS G+T+ + + +P++ P K + + Q + Sbjct: 188 --LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 Query: 284 -SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E S+ + +R + PE+ H +F Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >5Y86-A nrPDB Length = 588 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 106/228 (46%), Gaps = 18/228 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRAT----VNSQEQKRLLMDLDISMRTVDCPFTVT 114 +G+G++G V ++ Q +A+K +R + E+ R+L L +T Sbjct: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHM 274 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 FR +CM S+D + +K Q ++ K A SI+++L+ LH K Sbjct: 275 LESFTFRN---HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALH-KNK 330 Query: 175 VIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQK 232 +IH D+KP N+L+ G+ K+ DFG S + + I + + Y APE I L + Sbjct: 331 IIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS--RFYRAPEII---LGSR 385 Query: 233 GYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSPQL 278 YS DIWS G + EL + FP + G + +++ P P+L Sbjct: 386 -YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432 >6DBN-A nrPDB Length = 316 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 104/212 (49%), Gaps = 26/212 (12%) Query: 53 LEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ I +LG G +G VE R+ P +G+ +AVK ++ L +++I +R + Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEI-LRNLY 95 Query: 109 CPFTVTFYGALFREGD--VWICMELMDTSLDKFY----KQVIDKGQTIPEDILGKIAVSI 162 V + G +G + + ME + + K Y K I+ Q + K AV I Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQL------KYAVQI 149 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTI-DAGCKP-- 218 K +++L S+ +HRD+ NVL+ + QVK+ DFG++ + D T+ D P Sbjct: 150 CKGMDYLGSR-QYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVF 208 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 + APE L Q + + SD+WS G+T+ EL Sbjct: 209 WYAPEC----LMQSKFYIASDVWSFGVTLHEL 236 >5XZW-A nrPDB Length = 471 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 117/271 (43%), Gaps = 23/271 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G+GA+ V+K +G+ AVK I + +L++ ++ ++ P V G Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEV-LQKLNHPRIVRLKGF 262 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 ++ ME + S V G + ED +I+ I+ A++++HS + + HR Sbjct: 263 YEDTESYYMVMEFV--SGGDLMDFVAAHG-AVGEDAGREISRQILTAIKYIHS-MGISHR 318 Query: 179 DVKPSNVLINALG--QVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN---------- 226 D+KP N+LI VK+ DFG++ + G Y+APE I Sbjct: 319 DLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 378 Query: 227 -PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 283 E N+ YS D+WS+G + + P+ S T Q KQ+ + P F Sbjct: 379 YEERNE--YSSLVDMWSMGCLVYVILTGHLPF-SGSTQDQLYKQIGRGSYHEGPLKDFRI 435 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E DF L+ + R T + + HP+ Sbjct: 436 SEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >2DQ7-X nrPDB Length = 283 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 74/280 (26%), Positives = 125/280 (44%), Gaps = 22/280 (7%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + L+ I LG G +G V M +A+K ++ S E L + I M+ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEV-WMGTWNGNTKVAIKTLKPGTMSPES--FLEEAQI-MK 59 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + V Y A+ E ++I E M+ SL F K + +P L +A + Sbjct: 60 KLKHDKLVQLY-AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPN--LVDMAAQVAA 116 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 + ++ +++ IHRD++ +N+L+ K+ DFG++ L++ T G K + Sbjct: 117 GMAYIE-RMNYIHRDLRSANILVGNGLICKIADFGLA-RLIEDNEYTARQGAK--FPIKW 172 Query: 225 INPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGTP--FQQLKQVVEEPSPQLPA 280 PE G +++KSD+WS GI + EL R PY +Q+++ P PQ Sbjct: 173 TAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ--- 229 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHE 318 + C KK+ +ERPT+ L +FT E Sbjct: 230 -DCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATE 268 >4RC3-A nrPDB Length = 289 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/262 (23%), Positives = 114/262 (43%), Gaps = 23/262 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFT- 112 LG G +G V V +A+K RI R+ M++ + ++ V F+ Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSG 78 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V F D ++ + + + + ++G + E++ +++A+ H H+ Sbjct: 79 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHN- 136 Query: 173 LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 V+HRD+K N+LI+ G++K+ DFG L D+V D G + Y PE I Sbjct: 137 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIR---YH 192 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 + + + +WSLGI + ++ PF+ ++++ + S+E Sbjct: 193 RYHGRSAAVWSLGILLYDMV-------CGDIPFEHDEEIIR--GQVFFRQRVSSECQHLI 243 Query: 292 SQCLKKNSKERPTYPELMQHPF 313 CL +RPT+ E+ HP+ Sbjct: 244 RWCLALRPSDRPTFEEIQNHPW 265 >5FM2-A nrPDB Length = 355 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 67/281 (23%), Positives = 126/281 (44%), Gaps = 40/281 (14%) Query: 59 LGRGAYGVVEK-----MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG G +G V K ++ +AVK ++ + E + LL + ++ ++ V+ P + Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV-LKQVNHPHVI 130 Query: 114 TFYGALFREGDVWICMELMDT-SLDKFYKQVIDKG--------------------QTIPE 152 YGA ++G + + +E SL F ++ G + + Sbjct: 131 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM 190 Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSVAK 210 L A I + +++L +++ ++HRD+ N+L+ ++K+ DFG+S Y DS K Sbjct: 191 GDLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK 249 Query: 211 TIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQL 267 G P +MA E + + Y+ +SD+WS G+ + E+ L PY G P ++L Sbjct: 250 R-SQGRIPVKWMAIESLFDHI----YTTQSDVWSFGVLLWEIVTLGGNPYP--GIPPERL 302 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +++ D S E QC K+ +RP + ++ Sbjct: 303 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >4C59-A nrPDB Length = 340 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 73/276 (26%), Positives = 120/276 (43%), Gaps = 32/276 (11%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC-PFTVTFYG 117 L G + V + + V SG+ A+KR+ + N +E+ R ++ M+ + P V F Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRLLS--NEEEKNRAIIQEVCFMKKLSGHPNIVQFCS 92 Query: 118 AL--------FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 A + + + EL L +F K++ +G + +L KI +A++H+ Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVL-KIFYQTCRAVQHM 151 Query: 170 H-SKLSVIHRDVKPSNVLINALGQVKMCDFG----ISGYLVDS--------VAKTIDAGC 216 H K +IHRD+K N+L++ G +K+CDFG IS Y S V + I Sbjct: 152 HRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNT 211 Query: 217 KP-YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 P Y PE I+ N K DIW+LG + L + P++ G + + P Sbjct: 212 TPMYRTPEIIDLYSNFP-IGEKQDIWALGCILYLLCFRQHPFED-GAKLRIVNGKYSIP- 268 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 P D F L+ N +ER + E++ Sbjct: 269 ---PHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQ 301 >5TUR-A nrPDB Length = 404 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/263 (23%), Positives = 114/263 (43%), Gaps = 23/263 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFT- 112 LG G +G V V +A+K RI R+ M++ + ++ V F+ Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSG 193 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V F D ++ + + + + ++G + E++ +++A+ H H+ Sbjct: 194 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHN- 251 Query: 173 LSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 V+HRD+K N+LI+ G++K+ DFG L D+V D G + Y PE I Sbjct: 252 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIR---YH 307 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 + + + +WSLGI + ++ PF+ ++++ + S+E Sbjct: 308 RYHGRSAAVWSLGILLYDMVC-------GDIPFEHDEEIIR--GQVFFRQRVSSECQHLI 358 Query: 292 SQCLKKNSKERPTYPELMQHPFF 314 CL +RPT+ E+ HP+ Sbjct: 359 RWCLALRPSDRPTFEEIQNHPWM 381 >3BGP-A nrPDB Length = 333 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/262 (23%), Positives = 114/262 (43%), Gaps = 23/262 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFT- 112 LG G +G V V +A+K RI R+ M++ + ++ V F+ Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSG 122 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V F D ++ + + + + ++G + E++ +++A+ H H+ Sbjct: 123 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHN- 180 Query: 173 LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 V+HRD+K N+LI+ G++K+ DFG L D+V D G + Y PE I Sbjct: 181 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIR---YH 236 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 + + + +WSLGI + ++ PF+ ++++ + S+E Sbjct: 237 RYHGRSAAVWSLGILLYDMV-------CGDIPFEHDEEIIR--GQVFFRQRVSSECQHLI 287 Query: 292 SQCLKKNSKERPTYPELMQHPF 313 CL +RPT+ E+ HP+ Sbjct: 288 RWCLALRPSDRPTFEEIQNHPW 309 >3OMV-A nrPDB Length = 307 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 126/278 (45%), Gaps = 20/278 (7%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E++A ++ +G G++G V K + G + AVK ++ + EQ + + +R Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKW--HGDV-AVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + F G + ++ + +SL K K Q L IA + Sbjct: 88 KTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQ---LIDIARQTAQG 144 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD-SVAKTID--AGCKPYMAP 222 +++LH+K ++IHRD+K +N+ ++ VK+ DFG++ S ++ ++ G +MAP Sbjct: 145 MDYLHAK-NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAP 203 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-EPSPQLPA- 280 E I + N +S +SD++S GI + EL PY Q + V SP L Sbjct: 204 EVIRMQDNNP-FSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKL 262 Query: 281 -DKFSAEFVDFTSQCLKKNSKERPTYP------ELMQH 311 + C+KK +ERP +P EL+QH Sbjct: 263 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQH 300 >5HIE-A nrPDB Length = 302 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 47/158 (29%), Positives = 82/158 (51%), Gaps = 8/158 (5%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDSVAKTIDA 214 IA + +++LH+K S+IHRD+K +N+ ++ VK+ DFG++ S + Sbjct: 132 IARQTAQGMDYLHAK-SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS 190 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G +MAPE I + ++ YS +SD+++ GI + EL + PY + Q + V Sbjct: 191 GSILWMAPEVIRMQ-DKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGY 249 Query: 275 -SPQLPADKFSA--EFVDFTSQCLKKNSKERPTYPELM 309 SP L + + ++CLKK ERP +P+++ Sbjct: 250 LSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQIL 287 >1BYG-A nrPDB Length = 278 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 70/273 (25%), Positives = 123/273 (45%), Gaps = 26/273 (9%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 + + +L+ + +G+G +G V M G +AVK I+ +Q L + + M Sbjct: 15 GWALNMKELKLLQTIGKGEFGDV--MLGDYRGNKVAVKCIKNDATAQA---FLAEASV-M 68 Query: 105 RTVDCPFTVTFYGALFRE-GDVWICMELM-DTSLDKFYKQVIDKGQTI-PEDILGKIAVS 161 + V G + E G ++I E M SL + + +G+++ D L K ++ Sbjct: 69 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS---RGRSVLGGDCLLKFSLD 125 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--Y 219 + +A+E+L + +HRD+ NVL++ K+ DFG L + T D G P + Sbjct: 126 VCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFG----LTKEASSTQDTGKLPVKW 180 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIEL-AILRFPYDSWGTPFQQLKQVVEEPSPQL 278 APE L +K +S KSD+WS GI + E+ + R PY P + + VE+ Sbjct: 181 TAPE----ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKMD 234 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 D + C ++ RP++ +L + Sbjct: 235 APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQ 267 >6DBM-A nrPDB Length = 318 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 124/292 (42%), Gaps = 40/292 (13%) Query: 53 LEPIMELGRGAYGVVEKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ I +LG G +G V + P+ G+++AVK ++A Q + ++DI +RT+ Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDI-LRTLY 91 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + + G G + + + L + + + +L A I + + + Sbjct: 92 HEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLL--FAQQICEGMAY 149 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPE----- 223 LHS+ IHRD+ NVL++ VK+ DFG+ AK + G + Y E Sbjct: 150 LHSQ-HYIHRDLAARNVLLDNDRLVKIGDFGL--------AKAVPEGHEYYRVREDGDSP 200 Query: 224 --RINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------- 272 PE L + + SD+WS G+T+ EL S T F +L + + Sbjct: 201 VFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRL 260 Query: 273 ----EPSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF-TLHE 318 E +LP DK AE C + + RPT+ L+ P T+HE Sbjct: 261 TELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLI--PILKTVHE 310 >3NCG-A nrPDB Length = 486 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/280 (22%), Positives = 123/280 (43%), Gaps = 46/280 (16%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+G++G V K + + Q AVK I +A+ +++ +L ++++ ++ +D P + + Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVEL-LKKLDHPNIMKLFE 88 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 L +I EL + + ++I K + E +I + + ++H K +++H Sbjct: 89 ILEDSSSFYIVGELYTGG--ELFDEII-KRKRFSEHDAARIIKQVFSGITYMH-KHNIVH 144 Query: 178 RDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 RD+KP N+L+ + + +K+ DFG+S + G Y+APE + + Y Sbjct: 145 RDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL-----RGTY 199 Query: 235 SVKSDIWSLGITM---------------------IELAILRFPYDSWGTPFQQLKQVVEE 273 K D+WS G+ + +E F W T K ++ + Sbjct: 200 DEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRK 259 Query: 274 PSPQLPADKFSAEFVDFTSQCL-----KKNSKERPTYPEL 308 P+ + +A +QCL +K S E PT +L Sbjct: 260 MLTFHPSLRITA------TQCLEHPWIQKYSSETPTISDL 293 >2OZO-A nrPDB Length = 613 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 71/274 (25%), Positives = 130/274 (47%), Gaps = 29/274 (10%) Query: 57 MELGRGAYGVVEK-MRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 +ELG G +G V + + + QI +A+K ++ + + ++ + I M +D P+ V Sbjct: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVR 400 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G E + + ME+ +K ++ K + IP + ++ + +++L K + Sbjct: 401 LIGVCQAEA-LMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK-N 456 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKP--YMAPERINPELN 230 +HR++ NVL+ K+ DFG+S L DS AG P + APE IN Sbjct: 457 FVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN---- 512 Query: 231 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTP----FQQLKQVVEEPSPQLPADKFSA 285 + +S +SD+WS G+TM E L+ + PY P F + + +E P P+ P + ++ Sbjct: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP-PECPPELYA- 570 Query: 286 EFVDFTSQCLKKNSKERP---TYPELMQHPFFTL 316 S C ++RP T + M+ +++L Sbjct: 571 ----LMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 >4C0T-A nrPDB Length = 974 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 127/297 (42%), Gaps = 44/297 (14%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQE------QKRLLMDLDISMRTVDC 109 ELG G+Y V +G+ AVK + R + ++ +K L L + + Sbjct: 273 ELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISL 332 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 FT +L+ D EL+ +I + T+ E+ I+ A++++ Sbjct: 333 YFTFQDKDSLYFVLDYASNGELL---------TLIKRYNTLNEECTRHFGAQILDAIKYM 383 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV----DSVAKTIDAGCKPYMA-PER 224 H VIHRD+KP N+L++ ++++ DFG + L +S +D K ++ E Sbjct: 384 HDN-GVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEY 442 Query: 225 INPELNQKGYSVK-SDIWSLGITMIELAILRFPYDSWGT--PFQQLKQVVEEPSPQLPAD 281 ++PEL + Y K D+W+ G + ++ + P+ + FQ++ ++ Q Sbjct: 443 VSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL------QFA-- 494 Query: 282 KFSAEFVDFTSQCLKK----NSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 FSA F +KK R T PE+ +H FF + D F + L D Sbjct: 495 -FSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFF-----QSVDFKDFDSIWLSD 545 >4HVI-A nrPDB Length = 314 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 106/208 (50%), Gaps = 19/208 (9%) Query: 53 LEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ I +LG+G +G VE R+ P +G ++AVK+++ + +Q+ ++ I ++ + Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS-GPDQQRDFQREIQI-LKALH 69 Query: 109 CPFTVTFYGALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 F V + G + G + + ME + + + + Q + L + I K + Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ--RHRARLDASRLLLYSSQICKGM 127 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTI-DAGCKP--YMAP 222 E+L S+ +HRD+ N+L+ + VK+ DFG++ L +D + + G P + AP Sbjct: 128 EYLGSR-RCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAP 186 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIEL 250 E ++ + +S +SD+WS G+ + EL Sbjct: 187 ESLSDNI----FSRQSDVWSFGVVLYEL 210 >3HKO-A nrPDB Length = 345 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 76/310 (24%), Positives = 127/310 (40%), Gaps = 61/310 (19%) Query: 59 LGRGAYGVV-----EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 +G+G+YGVV + R + + +IM +IR +N ++ +R+ ++ + M+ + P Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIR-QINPKDVERIKTEVRL-MKKLHHPNIA 91 Query: 114 TFYGALFREGDVWICMEL-------------MDTSLDKFYKQVIDKGQTIP--------- 151 Y E + + MEL +D S K V+ K Q P Sbjct: 92 RLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVV-KTQICPCPECNEEAI 150 Query: 152 ----------------EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI--NALGQV 193 E ++ I I AL +LH++ + HRD+KP N L N ++ Sbjct: 151 NGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQ-GICHRDIKPENFLFSTNKSFEI 209 Query: 194 KMCDFGISGYLV-----DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 K+ DFG+S + T AG ++APE +N + Y K D WS G+ + Sbjct: 210 KLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNT--TNESYGPKCDAWSAGVLLH 267 Query: 249 ELAILRFPY---DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 L + P+ + T Q L + + +P + S D S L +N ER Sbjct: 268 LLLMGAVPFPGVNDADTISQVLNKKLCFENPNY--NVLSPLARDLLSNLLNRNVDERFDA 325 Query: 306 PELMQHPFFT 315 +QHP+ + Sbjct: 326 MRALQHPWIS 335 >5JZN-A nrPDB Length = 280 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 68/264 (25%), Positives = 126/264 (47%), Gaps = 22/264 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G G + VV++ + + A+K I+ + ++ + ++ I +R V P V Sbjct: 27 IGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSI-LRRVKHPNIVLLIEE 85 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 + ++++ MEL+ + + + D G + ++ A+++LHS L+++HR Sbjct: 86 MDVPTELYLVMELVKGG--DLFDAITSTNKYTERDASGML-YNLASAIKYLHS-LNIVHR 141 Query: 179 DVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 D+KP N+L+ + +K+ DFG++ +VD T+ G Y+APE I + GY Sbjct: 142 DIKPENLLVYEHQDGSKSLKLGDFGLAT-IVDGPLYTV-CGTPTYVAPEII----AETGY 195 Query: 235 SVKSDIWSLG-ITMIELAI---LRFPYDSWGTPFQQ-LKQVVEEPSPQLPADKFSAEFVD 289 +K DIW+ G IT I L R D F Q L V+ PSP D S + Sbjct: 196 GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYW--DNVSDSAKE 253 Query: 290 FTSQCLKKNSKERPTYPELMQHPF 313 + L + +R + ++++HP+ Sbjct: 254 LITMMLLVDVDQRFSAVQVLEHPW 277 >2H8H-A nrPDB Length = 535 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 72/269 (26%), Positives = 126/269 (46%), Gaps = 22/269 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + L ++LG+G +G V M +A+K ++ S E L + + M+ Sbjct: 262 WEIPRESLRLEVKLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEA--FLQEAQV-MK 317 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + V Y A+ E ++I E M SL F K K +P+ L +A I Sbjct: 318 KLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIAS 374 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 + ++ +++ +HRD++ +N+L+ K+ DFG++ L++ T G K + Sbjct: 375 GMAYVE-RMNYVHRDLRAANILVGENLVCKVADFGLA-RLIEDNEYTARQGAK--FPIKW 430 Query: 225 INPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPSPQLPA 280 PE G +++KSD+WS GI + EL R PY P ++V++ E ++P Sbjct: 431 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPC 485 Query: 281 DKFSAEFV-DFTSQCLKKNSKERPTYPEL 308 E + D QC +K +ERPT+ L Sbjct: 486 PPECPESLHDLMCQCWRKEPEERPTFEYL 514 >4UYA-A nrPDB Length = 340 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 48/181 (26%), Positives = 82/181 (45%), Gaps = 30/181 (16%) Query: 147 GQTIPEDILGKIAVSIVKALEHLHSK--LSVIHRDVKPSNVLINALGQ--------VKMC 196 G+ IP +L AV I + + +LH + + ++HRD+K SN+L+ + +K+ Sbjct: 118 GRRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKIT 177 Query: 197 DFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP 256 DFG++ K AG +MAPE I L KG SDIWS G+ + EL P Sbjct: 178 DFGLAREW-HRTTKMATAGAYAWMAPEVIKSSLFSKG----SDIWSYGVLLWELLTGEVP 232 Query: 257 YD-------SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 Y ++G +L + P+ F +C +++ RP++ ++ Sbjct: 233 YRGIDGLAVAYGVAVNKLTLPIPSTCPE--------PFAKLMKECWQQDPHIRPSFALIL 284 Query: 310 Q 310 + Sbjct: 285 E 285 >3ORP-A nrPDB Length = 311 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 92/202 (45%), Gaps = 17/202 (8%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 +I ME +D V +G P+ + IA +AL H +IHRDVKP+N+ Sbjct: 92 YIVMEYVDGV--TLRDIVHTEGPMTPKRAIEVIA-DACQALNFSHQN-GIIHRDVKPANI 147 Query: 186 LINALGQVKMCDFGISGYLVD---SVAKTIDA-GCKPYMAPERINPELNQKGYSV--KSD 239 +I+A VK+ DFGI+ + D SV +T G Y++PE+ +G SV +SD Sbjct: 148 MISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQ------ARGDSVDARSD 201 Query: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP-SPQLPADKFSAEFVDFTSQCLKKN 298 ++SLG + E+ P+ + V E+P P + SA+ + L KN Sbjct: 202 VYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKN 261 Query: 299 SKERPTYPELMQHPFFTLHESK 320 + R M+ +H + Sbjct: 262 PENRYQTAAEMRADLVRVHNGE 283 >3Q5I-A nrPDB Length = 504 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 102/208 (49%), Gaps = 25/208 (12%) Query: 55 PIMELGRGAYGVV----EKMRHVPSGQIMAVKRI-----RATVNSQEQKRLLMDL--DIS 103 + +LG GAYG V EK H I +K+ R + +++ ++ ++ +IS Sbjct: 40 KVRKLGSGAYGEVLLCKEKNGHSEKA-IKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEIS 98 Query: 104 M-RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + +++D P + + + ++ E + + ++Q+I++ E I I Sbjct: 99 LLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG--ELFEQIINR-HKFDECDAANIMKQI 155 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 + + +LH K +++HRD+KP N+L+ N+L +K+ DFG+S + G Y Sbjct: 156 LSGICYLH-KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYY 214 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITM 247 +APE + +K Y+ K D+WS G+ M Sbjct: 215 IAPEVL-----KKKYNEKCDVWSCGVIM 237 >5ZTN-A nrPDB Length = 429 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 75/255 (29%), Positives = 120/255 (47%), Gaps = 33/255 (12%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT----VNSQEQKRLL-----MDL 100 A E + +G+G++G V K Q +A+K +R + E+ R+L D Sbjct: 96 AYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDK 155 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICM--ELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 D +M + TF ICM EL+ +L + K+ +G ++P ++ K Sbjct: 156 DNTMNVIHMLENFTFRNH--------ICMTFELLSMNLYELIKKNKFQGFSLP--LVRKF 205 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGC 216 A SI++ L+ LH K +IH D+KP N+L+ G+ +K+ DFG S Y V I + Sbjct: 206 AHSILQCLDALH-KNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQS-- 262 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIEL--AILRFPYDSWGTPFQQLKQVVEEP 274 + Y APE I L + Y + D+WSLG + EL P + G + +++ P Sbjct: 263 RFYRAPEVI---LGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMP 318 Query: 275 SPQ-LPADKFSAEFV 288 S + L A K + FV Sbjct: 319 SQKLLDASKRAKNFV 333 >2ZMD-A nrPDB Length = 390 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 85/356 (23%), Positives = 151/356 (42%), Gaps = 52/356 (14%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYG 65 G K K ++ + P + D D KA S N+ VK + ++G G Sbjct: 16 GMKETAAAKFERQHMDSPDLGT----DDDDKASSS-ANECISVKGRIYSILKQIGSGGSS 70 Query: 66 VVEKMRHVPSGQIMAVKRIR------ATVNSQEQK-----RLLMDLDISMRTVDCPFTVT 114 V ++ + QI A+K + T++S + +L D +R D T Sbjct: 71 KVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQ 129 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + +++ ME + L+ + K K ++I ++++A+ +H Sbjct: 130 Y---------IYMVMECGNIDLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-G 175 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYL---VDSVAKTIDAGCKPYMAPERINPELNQ 231 ++H D+KP+N LI G +K+ DFGI+ + SV K G YM PE I + Sbjct: 176 IVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSS 234 Query: 232 K-------GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKF 283 + S KSD+WSLG + + + P+ +L +++ P+ ++ D Sbjct: 235 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID-PNHEIEFPDIP 293 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE------SKGTDVASFVKLILG 333 + D CLK++ K+R + PEL+ HP+ + +KGT +K +LG Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT--TEEMKYVLG 347 >6CTH-A nrPDB Length = 309 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 103/201 (51%), Gaps = 18/201 (8%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +LG G +G V + S +AVK++ + + Q K ++ I R + V G Sbjct: 22 KLGEGGFGSVYRGFLRDSDTYIAVKKV-SRASKQGIKEYASEVKIISR-LRHKNLVKLIG 79 Query: 118 ALFREGDVWICMELM-DTSLDKFYKQVIDKGQTI-PEDILGKIAVSIVKALEHLHSK--L 173 G++ + E M + SLD I KG+++ ++ +I + AL +LH + Sbjct: 80 WCHERGELMLVYEFMANGSLDSH----IFKGKSLLTWEVRYRIVKDLASALLYLHEEGDH 135 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVD---SVAKTIDAGCKPYMAPERINPELN 230 V+HRD+K SN+++++ K+ DFG++ LVD + KT+ AG YMAPE L+ Sbjct: 136 CVLHRDIKTSNIMLDSSFNAKLGDFGLA-RLVDHAKGLKKTLLAGTVGYMAPEC----LS 190 Query: 231 QKGYSVKSDIWSLGITMIELA 251 S +SD++S G+ +E+A Sbjct: 191 SGKASKESDVYSFGVVALEIA 211 >2BUJ-A nrPDB Length = 317 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 115/275 (41%), Gaps = 31/275 (11%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 I +LG G + V+ + + G A+KRI Q+++ + D+ R + P + Sbjct: 34 IQKLGEGGFSYVDLVEGLHDGHFYALKRILCH-EQQDREEAQREADMH-RLFNHPNILRL 91 Query: 116 YGALFRE----GDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 RE + W+ + +L +++ DKG + ED + + + I + LE +H Sbjct: 92 VAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIH 151 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN---- 226 +K HRD+KP+N+L+ GQ + D G V + A A +R Sbjct: 152 AK-GYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYR 210 Query: 227 -PELNQKGYSVKS--------DIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 PEL +SV+S D+WSLG + + PYD FQ+ V Q Sbjct: 211 APEL----FSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD---MVFQKGDSVALAVQNQ 263 Query: 278 LP---ADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 L + + S+ + + + +RP P L+ Sbjct: 264 LSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 >3HMP-A nrPDB Length = 342 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 79/333 (23%), Positives = 142/333 (42%), Gaps = 44/333 (13%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYG 65 G K K ++ + P + D D KA S N+ VK + ++G G Sbjct: 16 GMKETAAAKFERQHMDSPDLGT----DDDDKASSS-ANECISVKGRIYSILKQIGSGGSS 70 Query: 66 VVEKMRHVPSGQIMAVKRIR------ATVNSQEQK-----RLLMDLDISMRTVDCPFTVT 114 V ++ + QI A+K + T++S + +L D +R D T Sbjct: 71 KVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQ 129 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 + +++ ME + L+ + K K ++I ++++A+ +H Sbjct: 130 Y---------IYMVMECGNIDLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-G 175 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYL---VDSVAKTIDAGCKPYMAPERINPELNQ 231 ++H D+KP+N LI G +K+ DFGI+ + SV K G YM PE I + Sbjct: 176 IVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 234 Query: 232 K-------GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKF 283 + S KSD+WSLG + + + P+ +L +++ P+ ++ D Sbjct: 235 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID-PNHEIEFPDIP 293 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 + D CLK++ K+R + PEL+ HP+ + Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 326 >2Y4I-B nrPDB Length = 319 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 125/282 (44%), Gaps = 21/282 (7%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 SI Q +++ + LE +G+G +G V R G++ A++ I ++++Q + Sbjct: 22 SIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRW--HGEV-AIRLIDIERDNEDQLKAFKR 78 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 ++ R V F GA + I L Y V D + + +IA Sbjct: 79 EVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGR--TLYSVVRDAKIVLDVNKTRQIA 136 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG---ISGYLVDSVAK---TID 213 IVK + +LH+K ++H+D+K NV + G+V + DFG ISG L + I Sbjct: 137 QEIVKGMGYLHAK-GILHKDLKSKNVFYDN-GKVVITDFGLFSISGVLQAGRREDKLRIQ 194 Query: 214 AGCKPYMAPERI-----NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQL- 267 G ++APE I + E ++ +S SD+++LG EL +P+ + P + + Sbjct: 195 NGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT--QPAEAII 252 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 Q+ P L E D C +ERPT+ +LM Sbjct: 253 WQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM 294 >6J5U-C nrPDB Length = 426 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 71/280 (25%), Positives = 119/280 (42%), Gaps = 37/280 (13%) Query: 59 LGRGAYGVVEK---------MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 LG G +G V K SG ++AVK+++ Q K L +++ + + Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPE-GFQGHKEWLTEVNY-LGQLSH 149 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEH 168 P V G + + E M + +G Q + I K+AV K L Sbjct: 150 PNLVLLVGYCAEGENRLLVYEFMPKG--SLENHLFRRGAQPLTWAIRMKVAVGAAKGLTF 207 Query: 169 LH-SKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSV-AKTIDAGCKPYMAPER 224 LH +K VI+RD K +N+L++A K+ DFG+ +G D+ T G Y APE Sbjct: 208 LHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEY 267 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-----------WGTPF----QQLKQ 269 + + KSD++S G+ ++EL R D+ W TP+ ++L + Sbjct: 268 V----ATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDKRKLFR 323 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 +++ K + + QCL ++K RP E++ Sbjct: 324 IMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >3HNG-A nrPDB Length = 360 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 52/187 (27%), Positives = 89/187 (47%), Gaps = 34/187 (18%) Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMC 196 D FYK+ I ED++ + + + +E L S+ IHRD+ N+L++ VK+C Sbjct: 189 DGFYKEPI-----TMEDLIS-YSFQVARGMEFLSSR-KCIHRDLAARNILLSENNVVKIC 241 Query: 197 DFGISGYLV---DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL 253 DFG++ + D V K +MAPE I ++ YS KSD+WS G+ + E+ L Sbjct: 242 DFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKI----YSTKSDVWSYGVLLWEIFSL 297 Query: 254 RFPYDSWGTPF----------QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 G+P+ +L++ + +P+ + E C ++ KERP Sbjct: 298 G------GSPYPGVQMDEDFCSRLREGMRMRAPEYS----TPEIYQIMLDCWHRDPKERP 347 Query: 304 TYPELMQ 310 + EL++ Sbjct: 348 RFAELVE 354 >4OLI-A nrPDB Length = 645 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 129/292 (44%), Gaps = 40/292 (13%) Query: 53 LEPIMELGRGAYGVVEKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ I +LG G +G V + P+ G+++AVK ++A Q + ++DI +RT+ Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDI-LRTLY 413 Query: 109 CPFTVTFYGALFREGD--VWICMEL--MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + G +G+ + + ME + + D + I Q + A I + Sbjct: 414 HEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLL------LFAQQICE 467 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKP--YM 220 + +LHS+ IHR++ NVL++ VK+ DFG++ + + + + G P + Sbjct: 468 GMAYLHSQ-HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 526 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------- 272 APE L + + SD+WS G+T+ EL S T F +L + + Sbjct: 527 APEC----LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRL 582 Query: 273 ----EPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF-TLHE 318 E +LP DK E C + + RPT+ L+ P T+HE Sbjct: 583 TELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI--PILKTVHE 632 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 76/166 (45%), Gaps = 28/166 (16%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-------VKMCDFGISGYLVDSVAK 210 +A + AL +L +K +++H +V N+L+ LG +K+ D G+ + ++++ Sbjct: 172 VAQQLASALSYLENK-NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVG---LGALSR 227 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL-----AILRFPYDSWGTPFQ 265 P++APE + N S D W G T++E+ A L+ S F Sbjct: 228 EERVERIPWLAPECLPGGANS--LSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFY 285 Query: 266 QLKQVVEEPS-PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 Q + + EPS PQL TSQCL +RP++ +++ Sbjct: 286 QRQHRLPEPSCPQL---------ATLTSQCLTYEPTQRPSFRTILR 322 >5GRN-A nrPDB Length = 356 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 78/308 (25%), Positives = 130/308 (42%), Gaps = 54/308 (17%) Query: 43 NQNFEVKADDLEPIMELGRGAYG-VVEKM-----RHVPSGQIMAVKRIRATVNSQEQKRL 96 + +E D L LG GA+G VVE R P ++ AVK ++ T S E++ L Sbjct: 38 DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKV-AVKMLKPTARSSEKQAL 96 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICME-------------------------L 131 + +L I V GA + G ++I E + Sbjct: 97 MSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSM 156 Query: 132 MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG 191 +D+ + +G T+ + L + + +E L SK + +HRD+ NVL+ Sbjct: 157 LDSEVKNLLSDDNSEGLTLLD--LLSFTYQVARGMEFLASK-NCVHRDLAARNVLLAQGK 213 Query: 192 QVKMCDFGISGYLV---DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 VK+CDFG++ ++ + V+K +MAPE I L Y+ SD+WS GI + Sbjct: 214 IVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNL----YTTLSDVWSYGILLW 269 Query: 249 ELAIL-RFPY-----DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKER 302 E+ L PY DS T + ++K P D ++E + +C ++R Sbjct: 270 EIFSLGGTPYPGMMVDS--TFYNKIKSGYRMAKP----DHATSEVYEIMVKCWNSEPEKR 323 Query: 303 PTYPELMQ 310 P++ L + Sbjct: 324 PSFYHLSE 331 >3NIE-A nrPDB Length = 429 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 107/232 (46%), Gaps = 41/232 (17%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDC 109 D+ E +GRG+YG V + + +A+K++ R + + KR+L ++ I R + Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNR-LKS 86 Query: 110 PFTVTFYGA-----LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + + L + +++I +E+ D+ L K +K I + E + I +++ Sbjct: 87 DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPI----FLTEQHVKTILYNLLL 142 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--------YLVDSVAK------ 210 + +H +IHRD+KP+N L+N VK+CDFG++ ++V+ + + Sbjct: 143 GEKFIHES-GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEE 201 Query: 211 ------------TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 T + Y APE I L Q+ Y+ DIWS G EL Sbjct: 202 PGPHNKNLKKQLTSHVVTRWYRAPELI---LLQENYTNSIDIWSTGCIFAEL 250 >3DFA-A nrPDB Length = 286 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 105/215 (48%), Gaps = 17/215 (7%) Query: 40 SIGNQNFEVK---ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 S G +N + A+ + LG+G++G V K + + Q AVK I +A+ +++ Sbjct: 8 SSGRENLYFQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTST 67 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 +L ++++ ++ +D P + + L +I EL + + ++I K + E Sbjct: 68 ILREVEL-LKKLDHPNIMKLFEILEDSSSFYIVGELYTGG--ELFDEII-KRKRFSEHDA 123 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTI 212 +I + + ++H K +++HRD+KP N+L+ + + +K+ DFG+S + Sbjct: 124 ARIIKQVFSGITYMH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKD 182 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 G Y+APE + + Y K D+WS G+ + Sbjct: 183 RIGTAYYIAPEVL-----RGTYDEKCDVWSAGVIL 212 >5JN2-A nrPDB Length = 525 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 96/200 (48%), Gaps = 27/200 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG+G++G V + +GQ AVK I R +++ LL ++ + ++ +D P + Y Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL-LKQLDHPNIMKLY 133 Query: 117 ------GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 G + G+V+ EL D + + +D + I + ++ + ++H Sbjct: 134 EFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQ---------VLSGITYMH 184 Query: 171 SKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 K ++HRD+KP N+L+ + + +++ DFG+S + S G Y+APE ++ Sbjct: 185 -KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG 243 Query: 228 ELNQKGYSVKSDIWSLGITM 247 Y K D+WS G+ + Sbjct: 244 T-----YDEKCDVWSTGVIL 258 >3MA6-A nrPDB Length = 298 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 96/200 (48%), Gaps = 27/200 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG+G++G V + +GQ AVK I R +++ LL ++ + ++ +D P + Y Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL-LKQLDHPNIMKLY 98 Query: 117 ------GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 G + G+V+ EL D + + +D + I + ++ + ++H Sbjct: 99 EFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQ---------VLSGITYMH 149 Query: 171 SKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 K ++HRD+KP N+L+ + + +++ DFG+S + S G Y+APE ++ Sbjct: 150 -KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG 208 Query: 228 ELNQKGYSVKSDIWSLGITM 247 Y K D+WS G+ + Sbjct: 209 T-----YDEKCDVWSTGVIL 223 >5SYS-A nrPDB Length = 286 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 130/276 (47%), Gaps = 24/276 (8%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQEQKRLLM 98 + +E+ + L ++LG+G +G E +G +A+K ++ S E L Sbjct: 7 GLAKDAWEIPRESLRLEVKLGQGCFG--ECWMGTWNGTTRVAIKTLKPGTMSPEA--FLQ 62 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGK 157 + + M+ + V Y A+ E ++I E M SL F K + K +P+ L Sbjct: 63 EAQV-MKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQ--LVD 118 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217 +A I + ++ +++ +HRD++ +N+L+ K+ DFG++ L++ T G K Sbjct: 119 MAAQIASGMAYVE-RMNYVHRDLRAANILVGENLVCKVADFGLA-RLIEDNEYTARQGAK 176 Query: 218 PYMAPERINPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--E 273 + PE G +++KSD+WS GI + EL R PY P ++V++ E Sbjct: 177 --FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVE 229 Query: 274 PSPQLPADKFSAEFV-DFTSQCLKKNSKERPTYPEL 308 ++P E + D QC +K+ +ERPT+ L Sbjct: 230 RGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYL 265 >4XCU-A nrPDB Length = 300 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/268 (23%), Positives = 121/268 (45%), Gaps = 24/268 (8%) Query: 59 LGRGAYGVV---EKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 LG G +G V E P+ +AVK ++ + ++ L+ ++++ Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 84 Query: 112 TVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQT---IPEDILGKIAVSIVKALE 167 + G +EG +++ +E +L +F + G + + +L A + + ++ Sbjct: 85 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQ 144 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSVAKTIDAGCKP--YMAPE 223 +L S+ IHRD+ NVL+ +K+ DFG++ + +D KT + G P +MAPE Sbjct: 145 YLESR-KCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN-GRLPVKWMAPE 202 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 L + Y+ +SD+WS GI + E+ L PY G P ++L ++ E Sbjct: 203 ----ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP--GIPVEELFSLLREGHRMDRPPH 256 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQ 310 E +C +RPT+ +L++ Sbjct: 257 CPPELYGLMRECWHAAPSQRPTFKQLVE 284 >6F3F-A nrPDB Length = 455 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 71/269 (26%), Positives = 127/269 (47%), Gaps = 22/269 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + L ++LG+G +G V M +A+K ++ S E L + + M+ Sbjct: 182 WEIPRESLRLEVKLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEA--FLQEAQV-MK 237 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + V Y A+ E ++I E M+ SL F K K +P+ L ++ I Sbjct: 238 KLRHEKLVQLY-AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQ--LVDMSAQIAS 294 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 + ++ +++ +HRD++ +N+L+ K+ DFG++ L++ T G K + Sbjct: 295 GMAYVE-RMNYVHRDLRAANILVGENLVCKVADFGLA-RLIEDNEYTARQGAK--FPIKW 350 Query: 225 INPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPSPQLPA 280 PE G +++KSD+WS GI + EL R PY P ++V++ E ++P Sbjct: 351 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPC 405 Query: 281 DKFSAEFV-DFTSQCLKKNSKERPTYPEL 308 E + D QC +K +ERPT+ L Sbjct: 406 PPECPESLHDLMCQCWRKEPEERPTFEYL 434 >4H1J-A nrPDB Length = 293 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/287 (25%), Positives = 124/287 (43%), Gaps = 29/287 (10%) Query: 35 SKACISIGNQNFEVKADDLEPIMELGRGAYGVVEK---MRHVPSGQIMAVKRIR--ATVN 89 S + G+ + + +D+ LG G +G V + H +AVK + T++ Sbjct: 8 SSGLVPRGSPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLD 67 Query: 90 SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 ++E+ M + M+ +D P V G + E WI MEL Y + Sbjct: 68 NKEK---FMSEAVIMKNLDHPHIVKLIG-IIEEEPTWIIMELYPYGELGHYLERNKNSLK 123 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + +L ++ I KA+ +L S ++ +HRD+ N+L+ + VK+ DFG+S Y+ D Sbjct: 124 VLTLVL--YSLQICKAMAYLES-INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDY 180 Query: 210 KTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQL 267 P +M+PE I N + ++ SD+W + M E IL F PF L Sbjct: 181 YKASVTRLPIKWMSPESI----NFRRFTTASDVWMFAVCMWE--ILSFG----KQPFFWL 230 Query: 268 KQV----VEEPSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + V E +LP D ++C + +RP + EL+ Sbjct: 231 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELV 277 >3GUB-A nrPDB Length = 295 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 68/272 (25%), Positives = 127/272 (46%), Gaps = 31/272 (11%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-----MRTVDCPFT 112 ELG G + VV+K R +G A K I+ ++ +R + DI ++ + P Sbjct: 18 ELGSGQFAVVKKCREKSTGLQYAAKFIKKR-RTKSSRRGVSREDIEREVSILKEIQHPNV 76 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 +T + + DV + EL+ + + + +K +++ E+ + I+ + +LHS Sbjct: 77 ITLHEVYENKTDVILIGELVAGG--ELFDFLAEK-ESLTEEEATEFLKQILNGVYYLHS- 132 Query: 173 LSVIHRDVKPSNVLINALG----QVKMCDFGISGYLVDSVAKTIDAGCK---PYMAPERI 225 L + H D+KP N+++ ++K+ DFG+ A ID G + + PE + Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGL--------AHKIDFGNEFKNIFGTPEFV 184 Query: 226 NPEL-NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 PE+ N + +++D+WS+G+ L P+ G Q+ V + + + FS Sbjct: 185 APEIVNYEPLGLEADMWSIGVITYILLSGASPF--LGDTKQETLANVSAVNYEFEDEYFS 242 Query: 285 ---AEFVDFTSQCLKKNSKERPTYPELMQHPF 313 A DF + L K+ K+R T + +QHP+ Sbjct: 243 NTSALAKDFIRRLLVKDPKKRMTIQDSLQHPW 274 >5AP3-A nrPDB Length = 313 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 20/170 (11%) Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL---VDSVAKTIDAGCK 217 ++++A+ +H ++H D+KP+N LI G +K+ DFGI+ + SV K G Sbjct: 135 NMLEAVHTIHQH-GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTV 192 Query: 218 PYMAPERINPELNQK-------GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 YM PE I + + S KSD+WSLG + + + P+ +L + Sbjct: 193 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI 252 Query: 271 V----EEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 + E P +P + D CLK++ K+R + PEL+ HP+ + Sbjct: 253 IDPNHEIEFPDIP----EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 298 >2OGV-A nrPDB Length = 317 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 107/231 (46%), Gaps = 21/231 (9%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ-----IMAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 30 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 89 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDV-----WICMELMDTSLDKFYKQVIDKGQTIPE 152 +L I V GA G V + C + L + + +DK P Sbjct: 90 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPL 149 Query: 153 DI--LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK 210 ++ L + + + + L SK + IHRDV NVL+ K+ DFG++ +++ Sbjct: 150 ELRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 208 Query: 211 TIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PY 257 + + +MAPE I + Y+V+SD+WS GI + E+ L PY Sbjct: 209 IVKGNARLPVKWMAPESIFDCV----YTVQSDVWSYGILLWEIFSLGLNPY 255 >4X7Q-B nrPDB Length = 312 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 15/154 (9%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 +V A++H HS+ V+HRD+K N+LI+ G K+ DFG L D D G + Y Sbjct: 148 VVAAIQHCHSR-GVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFD-GTRVYS 205 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 PE I+ + +++ + +WSLGI + ++ P++ Q + E PA Sbjct: 206 PPEWIS---RHQYHALPATVWSLGILLYDMVCGDIPFER--------DQEILEAELHFPA 254 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S + +CL RP+ E++ P+ Sbjct: 255 -HVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM 287 >4NST-A nrPDB Length = 351 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 104/215 (48%), Gaps = 23/215 (10%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLLMDLDI 102 D + I +G G YG V K + +G+++A+K++R + + + ++L L I Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQL-I 70 Query: 103 SMRTVDCPFTVT-FYGAL-FRE--GDVWICMELMDTSLDKFYKQVIDKGQT-IPEDILGK 157 V+ VT AL F++ G ++ E MD L +++ G ED + Sbjct: 71 HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDL----MGLLESGLVHFSEDHIKS 126 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDAG 215 +++ LE+ H K + +HRD+K SN+L+N GQ+K+ DFG++ +S T Sbjct: 127 FMKQLMEGLEYCHKK-NFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 Y PE + L ++ Y+ D+WS G + EL Sbjct: 186 TLWYRPPELL---LGEERYTPAIDVWSCGCILGEL 217 >5XD6-A nrPDB Length = 305 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/131 (38%), Positives = 65/131 (49%), Gaps = 11/131 (8%) Query: 157 KIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK---T 211 KIAV + LE+LH K + VIHRD+K SNVL+ K+ DF +S D A+ T Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHST 189 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G Y APE S KSD++S G+ ++EL R P D QQ VV Sbjct: 190 RVLGTFGYHAPEYA----MTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQ--SVV 243 Query: 272 EEPSPQLPADK 282 +P+L DK Sbjct: 244 TWATPKLSEDK 254 >2JAM-A nrPDB Length = 304 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/279 (24%), Positives = 131/279 (46%), Gaps = 21/279 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTFYG 117 LG GA+ V ++ +G++ A+K I+ + ++ ++ +I+ ++ + VT Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSS---LENEIAVLKKIKHENIVTLED 73 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 ++ M+L+ S + + +++++G +D + ++ A+++LH ++H Sbjct: 74 IYESTTHYYLVMQLV--SGGELFDRILERGVYTEKDA-SLVIQQVLSAVKYLHEN-GIVH 129 Query: 178 RDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 RD+KP N+L ++ + DFG+S + + T G Y+APE L QK Y Sbjct: 130 RDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTA-CGTPGYVAPEV----LAQKPY 184 Query: 235 SVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQ-VVEEPSPQLPADKFSAEFVDFT 291 S D WS+G+ L P+ ++ F+++K+ E SP D S DF Sbjct: 185 SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFW--DDISESAKDFI 242 Query: 292 SQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKL 330 L+K+ ER T + + HP+ + + D+ V L Sbjct: 243 CHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSL 281 >3TT0-A nrPDB Length = 382 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/293 (23%), Positives = 127/293 (43%), Gaps = 39/293 (13%) Query: 46 FEVKADDLEPIMELGRGAYGVV----------EKMRHVPSGQIMAVKRIRATVNSQEQKR 95 +E+ D L LG GA+G V +K V +AVK +++ ++ Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTK---VAVKMLKSDATEKDLSD 120 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-------------LDKFYKQ 142 L+ ++++ + GA ++G +++ +E L+ Y Sbjct: 121 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNP 180 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + + L A + + +E+L SK IHRD+ NVL+ +K+ DFG++ Sbjct: 181 SHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLAR 239 Query: 203 --YLVDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPY 257 + +D KT + G P +MAPE L + Y+ +SD+WS G+ + E+ L PY Sbjct: 240 DIHHIDYYKKTTN-GRLPVKWMAPE----ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 294 Query: 258 DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 295 P--GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 345 >6GVJ-A nrPDB Length = 429 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 76/317 (23%), Positives = 136/317 (42%), Gaps = 38/317 (11%) Query: 21 EQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMA 80 +Q Q +TP ++L A S N+ VK + ++G G V ++ + QI A Sbjct: 115 QQHQILATPLQNLQVLASSS-ANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYA 172 Query: 81 VKRIR------ATVNSQEQK-----RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICM 129 +K + T++S + +L D +R D T + +++ M Sbjct: 173 IKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQY---------IYMVM 223 Query: 130 ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189 E + L+ + K K ++I ++++A+ +H ++H D+KP+N LI Sbjct: 224 ECGNIDLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-GIVHSDLKPANFLI-V 277 Query: 190 LGQVKMCDFGISGYL---VDSVAKTIDAGCKPYMAPERINPELNQK-------GYSVKSD 239 G +K+ DFGI+ + SV K G YM PE I + + S KSD Sbjct: 278 DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSD 337 Query: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNS 299 +WSLG + + + P+ +L +++ D + D CLK++ Sbjct: 338 VWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDP 397 Query: 300 KERPTYPELMQHPFFTL 316 K+R + PEL+ HP+ + Sbjct: 398 KQRISIPELLAHPYVQI 414 >3GQL-A nrPDB Length = 326 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/293 (23%), Positives = 127/293 (43%), Gaps = 39/293 (13%) Query: 46 FEVKADDLEPIMELGRGAYGVV----------EKMRHVPSGQIMAVKRIRATVNSQEQKR 95 +E+ D L LG GA+G V +K V +AVK +++ ++ Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTK---VAVKMLKSDATEKDLSD 79 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-------------LDKFYKQ 142 L+ ++++ + GA ++G +++ +E L+ Y Sbjct: 80 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 139 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + + L A + + +E+L SK IHRD+ NVL+ +K+ DFG++ Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLAR 198 Query: 203 --YLVDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPY 257 + +D KT + G P +MAPE L + Y+ +SD+WS G+ + E+ L PY Sbjct: 199 DIHHIDYYKKTTN-GRLPVKWMAPE----ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 253 Query: 258 DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 254 P--GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVE 304 >5A46-A nrPDB Length = 386 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/250 (22%), Positives = 112/250 (44%), Gaps = 26/250 (10%) Query: 79 MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS--- 135 +AVK +++ ++ L+ ++++ + GA ++G +++ +E Sbjct: 75 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 134 Query: 136 ----------LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 L+ Y + + + L A + + +E+L SK IHRD+ NV Sbjct: 135 EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNV 193 Query: 186 LINALGQVKMCDFGISG--YLVDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIW 241 L+ +K+ DFG++ + +D KT + G P +MAPE L + Y+ +SD+W Sbjct: 194 LVTEDNVMKIADFGLARDIHHIDYYKKTTN-GRLPVKWMAPE----ALFDRIYTHQSDVW 248 Query: 242 SLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 S G+ + E+ L PY G P ++L ++++E + E C Sbjct: 249 SFGVLLWEIFTLGGSPYP--GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 306 Query: 301 ERPTYPELMQ 310 +RPT+ +L++ Sbjct: 307 QRPTFKQLVE 316 >4PDS-A nrPDB Length = 347 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 68/273 (24%), Positives = 117/273 (42%), Gaps = 23/273 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G+GA+ V+K +G+ +VK I + +L++ ++ ++ P V G Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEV-LQKLNHPRIVRLKGF 97 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 ++ ME + S V G + ED +I+ I+ A++++HS + + HR Sbjct: 98 YEDTESYYMVMEFV--SGGDLMDFVAAHG-AVGEDAGREISRQILTAIKYIHS-MGISHR 153 Query: 179 DVKPSNVLINALG--QVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN---------- 226 D+KP N+LI VK+ FG++ + G Y+APE I Sbjct: 154 DLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 213 Query: 227 -PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 283 E N+ YS D+WS+G + + P+ S T Q KQ+ + P F Sbjct: 214 YEERNE--YSSLVDMWSMGCLVYVILTGHLPF-SGSTQDQLYKQIGRGSYHEGPLKDFRI 270 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 S E DF L+ + R T + + HP+ + Sbjct: 271 SEEARDFIDSLLQVDPNNRSTAAKALNHPWIKM 303 >3I6U-A nrPDB Length = 419 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/289 (23%), Positives = 131/289 (45%), Gaps = 19/289 (6%) Query: 39 ISIGNQNFEVKADDLEPIME--LGRGAYGVVEKMRHVPSGQIMAVKRI---RATVNSQEQ 93 +++ +Q+ KA E IM LG GA G V+ + + +A++ I + + S + Sbjct: 121 LTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSARE 180 Query: 94 KRLLMDLDIS---MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTI 150 ++++ ++ ++ P + F D +I +ELM+ + + +V+ + + Sbjct: 181 ADPALNVETEIEILKKLNHPCIIKIKN-FFDAEDYYIVLELMEGG--ELFDKVVG-NKRL 236 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDS 207 E ++ A+++LH +IHRD+KP NVL+++ + +K+ DFG S L ++ Sbjct: 237 KEATCKLYFYQMLLAVQYLHEN-GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGET 295 Query: 208 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQL 267 G Y+APE + + GY+ D WSLG+ + P+ T Sbjct: 296 SLMRTLCGTPTYLAPE-VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK 354 Query: 268 KQVVEEPSPQLPA--DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 Q+ +P + S + +D + L + K R T E ++HP+ Sbjct: 355 DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 403 >2YCR-A nrPDB Length = 323 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 120/267 (44%), Gaps = 17/267 (6%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI---RATVNSQEQKRLLMDLDIS---MRTVDCPFT 112 LG GA G V+ + + +A+K I + + S + ++++ ++ ++ P Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 + F D +I +ELM+ + + +V+ + + E ++ A+++LH Sbjct: 78 IKIKN-FFDAEDYYIVLELMEGG--ELFDKVVG-NKRLKEATCKLYFYQMLLAVQYLHEN 133 Query: 173 LSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 +IHRD+KP NVL+++ + +K+ DFG S L ++ G Y+APE + + Sbjct: 134 -GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPE-VLVSV 191 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA--DKFSAEF 287 GY+ D WSLG+ + P+ T Q+ +P + S + Sbjct: 192 GTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKA 251 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFF 314 +D + L + K R T E ++HP+ Sbjct: 252 LDLVKKLLVVDPKARFTTEEALRHPWL 278 >4RT7-A nrPDB Length = 415 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 48/162 (29%), Positives = 80/162 (49%), Gaps = 13/162 (8%) Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 ED+L A + K +E L K S +HRD+ NVL+ VK+CDFG++ ++ Sbjct: 243 EDLLC-FAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYV 300 Query: 212 IDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQL 267 + + +MAPE L + Y++KSD+WS GI + E+ L PY G P Sbjct: 301 VRGNARLPVKWMAPE----SLFEGIYTIKSDVWSYGILLWEIFSLGVNPYP--GIPVDAN 354 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQ-CLKKNSKERPTYPEL 308 + + ++ ++ E + Q C +S++RP++P L Sbjct: 355 FYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 >3I81-A nrPDB Length = 315 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 66/281 (23%), Positives = 125/281 (44%), Gaps = 26/281 (9%) Query: 46 FEVKADDLEPIMELGRGAYGVVEK------MRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 +EV + + ELG+G++G+V + ++ P ++ A+K + + +E+ L + Sbjct: 13 WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRV-AIKTVNEAASMRERIEFLNE 71 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFY----KQVIDKGQTIPEDIL 155 + M+ +C V G + + + MELM K Y + ++ + L Sbjct: 72 ASV-MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 130 Query: 156 GKI---AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSVAK 210 K+ A I + +L++ +HRD+ N ++ VK+ DFG++ Y D K Sbjct: 131 SKMIQMAGEIADGMAYLNAN-KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRK 189 Query: 211 TIDAGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLK 268 G K + ++PE + G ++ SD+WS G+ + E+A L PY G +Q+ Sbjct: 190 ----GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQ--GLSNEQVL 243 Query: 269 QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + V E D + C + N K RP++ E++ Sbjct: 244 RFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEII 284 >1U54-B nrPDB Length = 291 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 73/276 (26%), Positives = 125/276 (45%), Gaps = 38/276 (13%) Query: 52 DLEPIMELGRGAYGVVEKMR-HVPSGQIM--AVKRIRATVNSQEQKRLLMDLDI----SM 104 DL + +LG G++GVV + PSG+ + AVK ++ V SQ + MD I +M Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEA---MDDFIREVNAM 75 Query: 105 RTVDCPFTVTFYGALFREGDVWICMEL--MDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 ++D + YG + + + EL + + LD+ K +G + L + AV + Sbjct: 76 HSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKH---QGHFL-LGTLSRYAVQV 130 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--------SGYLVDSVAKTIDA 214 + + +L SK IHRD+ N+L+ VK+ DFG+ Y++ K A Sbjct: 131 AEGMGYLESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFA 189 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW-GTPFQQLKQVVEE 273 C APE L + +S SD W G+T+ E+ + + W G Q+ +++ Sbjct: 190 WC----APE----SLKTRTFSHASDTWMFGVTLWEM--FTYGQEPWIGLNGSQILHKIDK 239 Query: 274 PSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +LP + + + QC ++RPT+ L Sbjct: 240 EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 275 >3VHK-A nrPDB Length = 368 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 45/157 (28%), Positives = 76/157 (48%), Gaps = 10/157 (6%) Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV---DSVAKTIDAG 215 + + K +E L S+ IHRD+ N+L++ VK+CDFG++ + D V K Sbjct: 206 SFQVAKGMEFLASR-KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 264 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEP 274 +MAPE I + Y+++SD+WS G+ + E+ L PY + +++ E Sbjct: 265 PLKWMAPETIFDRV----YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGT 320 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + P D + E C +RPT+ EL++H Sbjct: 321 RMRAP-DYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 >4HZS-A nrPDB Length = 341 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 73/276 (26%), Positives = 125/276 (45%), Gaps = 38/276 (13%) Query: 52 DLEPIMELGRGAYGVVEKMRH-VPSGQIM--AVKRIRATVNSQEQKRLLMDLDI----SM 104 DL + +LG G++GVV + PSG+ + AVK ++ V SQ + MD I +M Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEA---MDDFIREVNAM 69 Query: 105 RTVDCPFTVTFYGALFREGDVWICMEL--MDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 ++D + YG + + + EL + + LD+ K +G + L + AV + Sbjct: 70 HSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKH---QGHFL-LGTLSRYAVQV 124 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--------SGYLVDSVAKTIDA 214 + + +L SK IHRD+ N+L+ VK+ DFG+ Y++ K A Sbjct: 125 AEGMGYLESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFA 183 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW-GTPFQQLKQVVEE 273 C APE L + +S SD W G+T+ E+ + + W G Q+ +++ Sbjct: 184 WC----APE----SLKTRTFSHASDTWMFGVTLWEM--FTYGQEPWIGLNGSQILHKIDK 233 Query: 274 PSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +LP + + + QC ++RPT+ L Sbjct: 234 EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVAL 269 >5EFQ-A nrPDB Length = 347 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 103/217 (47%), Gaps = 27/217 (12%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLLMDLD- 101 D + I +G G YG V K R +G+++A+K++R + + + ++L L Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 102 ---ISMRTV--DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT-IPEDIL 155 I+M+ + D + F +G ++ E MD L +++ G E+ + Sbjct: 70 QSIINMKEIVTDKEDALDFKKD---KGAFYLVFEYMDHDL----MGLLESGLVHFNENHI 122 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK--TID 213 +++ L++ H K + +HRD+K SN+L+N GQ+K+ DFG++ ++ T Sbjct: 123 KSFMRQLMEGLDYCHKK-NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNK 181 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 Y PE + L ++ Y+ D+WS G + EL Sbjct: 182 VITLWYRPPELL---LGEERYTPAIDVWSCGCILGEL 215 >2PVN-A nrPDB Length = 352 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/189 (25%), Positives = 85/189 (44%), Gaps = 40/189 (21%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 ++KAL++ HS+ ++HRDVKP NV+I + L ++++ D+G++ + + + + Sbjct: 155 LLKALDYCHSQ-GIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFK 213 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------- 272 PE + ++ + Y D+WSLG + + P+ QL ++ + Sbjct: 214 GPELL---VDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLN 270 Query: 273 --------EPSPQL----------PADKF---------SAEFVDFTSQCLKKNSKERPTY 305 E PQL P KF S E +DF + L+ + +ER T Sbjct: 271 AYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTA 330 Query: 306 PELMQHPFF 314 E M HP+F Sbjct: 331 LEAMTHPYF 339 >3DLS-A nrPDB Length = 335 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 68/270 (25%), Positives = 112/270 (41%), Gaps = 35/270 (12%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIR-------ATVNSQEQKRLLMDLDISMRTVDCPF 111 LG GA+G V + + VK I+ + + ++ +++ I R V+ Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR-VEHAN 90 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + +G + ME + LD F ID+ + E + I +V A+ +L Sbjct: 91 IIKVLDIFENQGFFQLVMEKHGSGLDLF--AFIDRHPRLDEPLASYIFRQLVSAVGYLRL 148 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI------ 225 K +IHRD+K N++I +K+ DFG + YL G Y APE + Sbjct: 149 K-DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYR 207 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 PEL ++WSLG+T+ L PF +L++ VE + P S Sbjct: 208 GPEL---------EMWSLGVTLYTLVFEE-------NPFCELEETVE--AAIHPPYLVSK 249 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 E + S L+ + R T +L+ P+ T Sbjct: 250 ELMSLVSGLLQPVPERRTTLEKLVTDPWVT 279 >4YFF-A nrPDB Length = 311 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 63/232 (27%), Positives = 101/232 (43%), Gaps = 40/232 (17%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 +F ++ ++E +G G++G V K R +I+A+KR RA + D+D+ Sbjct: 36 HFHLQLSEIEFHEIIGSGSFGKVYKGR--CRNKIVAIKRYRANTYCSKS-----DVDMFC 88 Query: 105 RTV------DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG--------QTI 150 R V + P + F GA L D S Q I G Q Sbjct: 89 REVSILCQLNHPCVIQFVGAC-----------LNDPSQFAIVTQYISGGSLFSLLHEQKR 137 Query: 151 PEDILGK--IAVSIVKALEHLHSKLS-VIHRDVKPSNVLINALGQVKMCDFGISGYL--V 205 D+ K IAV + K +E+LH+ +IHRD+ N+L+ G + DFG S +L + Sbjct: 138 ILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 197 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 D T G +MAPE Y++K+D++S + + E+ P+ Sbjct: 198 DEDNMTKQPGNLRWMAPEVFT---QCTRYTIKADVFSYALCLWEILTGEIPF 246 >3QA8-A nrPDB Length = 676 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 89/200 (44%), Gaps = 15/200 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 115 LG G +G V + H +G+ +A+K+ R ++ + ++R +++ I M+ ++ P V+ Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQI-MKKLNHPNVVSAREV 80 Query: 116 ---YGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 L + ME + + Y + + E + + I AL +LH Sbjct: 81 PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHEN 140 Query: 173 LSVIHRDVKPSNVLINALGQV---KMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 +IHRD+KP N+++ Q K+ D G + L T G Y+APE L Sbjct: 141 -RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPEL----L 195 Query: 230 NQKGYSVKSDIWSLGITMIE 249 QK Y+V D WS G E Sbjct: 196 EQKKYTVTVDYWSFGTLAFE 215 >3BEA-A nrPDB Length = 333 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/237 (26%), Positives = 105/237 (44%), Gaps = 29/237 (12%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ-----IMAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 97 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILG 156 +L I V GA G V + E L F ++ K + + D Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRR---KSRVLETDPAF 154 Query: 157 KIAVSIVKALEHLH------------SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 IA S + + LH + + IHRDV NVL+ K+ DFG++ + Sbjct: 155 AIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 214 Query: 205 VDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PY 257 ++ + + +MAPE I + Y+V+SD+WS GI + E+ L PY Sbjct: 215 MNDSNYIVKGNARLPVKWMAPESIFDCV----YTVQSDVWSYGILLWEIFSLGLNPY 267 >1KOB-A nrPDB Length = 387 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 62/270 (22%), Positives = 123/270 (45%), Gaps = 18/270 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D + + ELG GA+GVV + +G++ K I T ++ + ++ I M + P Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFIN-TPYPLDKYTVKNEISI-MNQLHHP 108 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 + + A + ++ + +E + S + + ++ + + E + + L+H+H Sbjct: 109 KLINLHDAFEDKYEMVLILEFL--SGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMH 166 Query: 171 SKLSVIHRDVKPSNVLINA--LGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINP 227 S++H D+KP N++ VK+ DFG++ L D + K A + + APE ++ Sbjct: 167 EH-SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAE-FAAPEIVDR 224 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA-- 285 E +D+W++G+ L P+ G + Q V+ + D FS+ Sbjct: 225 E----PVGFYTDMWAIGVLGYVLLSGLSPFA--GEDDLETLQNVKRCDWEFDEDAFSSVS 278 Query: 286 -EFVDFTSQCLKKNSKERPTYPELMQHPFF 314 E DF L+K ++R T + ++HP+ Sbjct: 279 PEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308 >2HW6-A nrPDB Length = 307 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 94/205 (45%), Gaps = 43/205 (20%) Query: 144 IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGI 200 I K + E ++ + AL+ LH+K + HRD+KP N+L + + VK+CDF + Sbjct: 102 IQKQKHFNEREASRVVRDVAAALDFLHTK-GIAHRDLKPENILCESPEKVSPVKICDFDL 160 Query: 201 -SGYLVDSVAK-------TIDAGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELA 251 SG +++ T G YMAPE + +Q Y + D+WSLG+ + + Sbjct: 161 GSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY-IM 219 Query: 252 ILRFPYDSWGTPF--------------------QQLKQVVEEPSPQLPADKF---SAEFV 288 + +P PF +L + ++E + P + S+E Sbjct: 220 LSGYP------PFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAK 273 Query: 289 DFTSQCLKKNSKERPTYPELMQHPF 313 D S+ L +++K+R + +++QHP+ Sbjct: 274 DLISKLLVRDAKQRLSAAQVLQHPW 298 >6O6Q-A nrPDB Length = 335 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 44/188 (23%), Positives = 84/188 (44%), Gaps = 39/188 (20%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQ-VKMCDFGISGYLVDSVAKTIDAGCKPYM 220 ++KAL++ HS + ++HRDVKP NV+I+ + +++ D+G++ Y + + + Sbjct: 144 LLKALDYSHS-MGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFK 202 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV--------- 271 PE + ++ + Y D+WS G + + ++ P+ + QL Q+V Sbjct: 203 GPELL---VDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFK 259 Query: 272 ---EEPSPQL----------------------PADKFSAEFVDFTSQCLKKNSKERPTYP 306 E+ + L D S EF+D + L+ + +ER T Sbjct: 260 KYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAK 319 Query: 307 ELMQHPFF 314 E M+H +F Sbjct: 320 EAMKHAYF 327 >4RGJ-A nrPDB Length = 520 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 69/278 (24%), Positives = 126/278 (45%), Gaps = 35/278 (12%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG+G++G V R +G A+K I + +++ LL ++++ ++ +D + Y Sbjct: 68 LGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVEL-LKMLDHINIMKLY 126 Query: 117 ------GALFREGDVWICMELMD--TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + DV+ EL D S +FY+ ID + I + I+ + + Sbjct: 127 EFFEDNNYYYLVSDVYTGGELFDEIISRKRFYE--IDAARIIKQ---------ILSGITY 175 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ----VKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 +H K +V+HRD+KP N+L+ + +K+ DFG+S + S G Y+AP+ Sbjct: 176 MH-KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-VEEPSPQLPA-DK 282 ++ Y K DIWS G+ + L P++ + LK+V + + LP K Sbjct: 235 LHGT-----YDEKCDIWSCGVILYILLSGCPPFNG-SNEYDILKKVEAGKYTFDLPQFKK 288 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 S + D + L S R + + ++H + + SK Sbjct: 289 ISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSK 326 >3KRL-A nrPDB Length = 335 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 106/237 (44%), Gaps = 27/237 (11%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ-----IMAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 97 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICME------LMD-------TSLDKFYKQVI 144 +L I V GA G V + E L++ L+ Y Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSH 157 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 + + + L + + + + L SK + IHRDV NVL+ K+ DFG++ + Sbjct: 158 NPEEQLSSRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGDFGLARDI 216 Query: 205 VDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PY 257 ++ + + +MAPE I + Y+V+SD+WS GI + E+ L PY Sbjct: 217 MNDSNYIVKGNARLPVKWMAPESIFDCV----YTVQSDVWSYGILLWEIFSLGLNPY 269 >5E8V-A nrPDB Length = 316 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 15/118 (12%) Query: 148 QTIPEDILGKIAVSIVKALEHLHS--------KLSVIHRDVKPSNVLINALGQVKMCDFG 199 I + L K+ S+ + + HLHS K+ ++HRD+K SN+L+ +CDFG Sbjct: 107 HVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFG 166 Query: 200 ISGYL-----VDSVAKTIDAGCKPYMAPERINPELNQKGYSV--KSDIWSLGITMIEL 250 +S L VD +A + G YMAPE + +N + ++D++S+ + + E+ Sbjct: 167 LSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEM 224 >4R7H-A nrPDB Length = 343 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 107/244 (43%), Gaps = 34/244 (13%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ-----IMAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 42 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 101 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-LDKFYK--------------- 141 +L I V GA G V + E L F + Sbjct: 102 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQ 161 Query: 142 --QVIDKGQTIPEDI--LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 + +DK P ++ L + + + + L SK + IHRDV NVL+ K+ D Sbjct: 162 DPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGD 220 Query: 198 FGISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 254 FG++ +++ + + +MAPE I + Y+V+SD+WS GI + E+ L Sbjct: 221 FGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSV----YTVQSDVWSYGILLWEIFSLG 276 Query: 255 F-PY 257 PY Sbjct: 277 LNPY 280 >6CKI-A nrPDB Length = 316 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 84/180 (46%), Gaps = 29/180 (16%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLI---NALGQVKMCDFGI-SGYLVDSVAKTID---- 213 + AL+ LH+K + HRD+KP N+L N + VK+CDFG+ SG ++ I Sbjct: 120 VASALDFLHNK-GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPEL 178 Query: 214 ---AGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPY-------DSW-- 260 G YMAPE + + Y + D+WSLG+ + L P+ W Sbjct: 179 LTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDR 238 Query: 261 --GTPFQQ--LKQVVEEPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPF 313 P Q L + ++E + P + S D S+ L +++K+R + +++QHP+ Sbjct: 239 GEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPW 298 >3QD2-B nrPDB Length = 332 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 49/173 (28%), Positives = 84/173 (48%), Gaps = 28/173 (16%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG-ISGYLVDSVAKTI---- 212 I + I +A+E LHSK ++HRD+KPSN+ VK+ DFG ++ D +T+ Sbjct: 169 IFIQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 227 Query: 213 --------DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF 264 G K YM+PE+I + YS K DI+SLG+ + EL S+ T Sbjct: 228 PAYATHTGQVGTKLYMSPEQI----HGNNYSHKVDIFSLGLILFELLY------SFSTQM 277 Query: 265 QQLKQVVEEPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 ++++ + + + + P K+ E + L + ERP +++++ F Sbjct: 278 ERVRIITDVRNLKFPLLFTQKYPQEHM-MVQDMLSPSPTERPEATDIIENAIF 329 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 37/67 (55%), Gaps = 1/67 (1%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 D EPI +GRG +GVV + ++ A+KRIR +++++ ++ ++ ++ P Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVK-ALAKLEHPG 65 Query: 112 TVTFYGA 118 V ++ A Sbjct: 66 IVRYFNA 72 >3G0E-A nrPDB Length = 336 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 68/277 (24%), Positives = 119/277 (42%), Gaps = 32/277 (11%) Query: 59 LGRGAYG-VVEKMRH----VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG GA+G VVE + + +AVK ++ + + E++ L+ +L + + V Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIV 113 Query: 114 TFYGALFREGDVWICMELMDTS-LDKFYKQVIDK---GQTIPEDILG-----------KI 158 GA G + E L F ++ D +T P + Sbjct: 114 NLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSF 173 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK- 217 + + K + L SK + IHRD+ N+L+ K+CDFG++ + + + + Sbjct: 174 SYQVAKGMAFLASK-NCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARL 232 Query: 218 --PYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPF-QQLKQVVEE 273 +MAPE I + Y+ +SD+WS GI + EL L PY G P + ++++E Sbjct: 233 PVKWMAPESIFNCV----YTFESDVWSYGIFLWELFSLGSSPYP--GMPVDSKFYKMIKE 286 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 L + AE D C + +RPT+ +++Q Sbjct: 287 GFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >3PFQ-A nrPDB Length = 674 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 69/288 (23%), Positives = 124/288 (43%), Gaps = 34/288 (11%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 GN++ +K D +M LG+G++G V + ++ AVK ++ V ++ D D Sbjct: 333 GNRD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-------VIQDDD 384 Query: 102 ISMRTVDC---------PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE 152 + V+ PF + ++ ME ++ ++ Q + + + P Sbjct: 385 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PH 443 Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKT 211 + A I L L SK +I+RD+K NV++++ G +K+ DFG+ + D V Sbjct: 444 AVF--YAAEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTK 500 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G Y+APE I + Y D W+ G+ + E+ + P++ G +L Q + Sbjct: 501 TFCGTPDYIAPEII----AYQPYGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQSI 554 Query: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKER-PTYPE----LMQHPFF 314 E + P S E V + K+ +R PE + +H FF Sbjct: 555 MEHNVAYPK-SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 601 >3F3Z-A nrPDB Length = 277 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/262 (23%), Positives = 117/262 (44%), Gaps = 19/262 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +GRG++G V+ + A K+I ++ R +++I M+++D P + Y Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKI-PKYFVEDVDRFKQEIEI-MKSLDHPNIIRLYET 74 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 D+++ MEL + +++V+ K + E +I ++ A+ + H KL+V HR Sbjct: 75 FEDNTDIYLVMELCTGG--ELFERVVHK-RVFRESDAARIMKDVLSAVAYCH-KLNVAHR 130 Query: 179 DVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 D+KP N L + +K+ DFG++ G P ++P++ + Y Sbjct: 131 DLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVG-----TPYYVSPQVLEGLYG 185 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF---SAEFVDFTS 292 + D WS G+ M L P+ + LK + E + P + S + Sbjct: 186 PECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLK--IREGTFTFPEKDWLNVSPQAESLIR 243 Query: 293 QCLKKNSKERPTYPELMQHPFF 314 + L K+ K+R T + ++H +F Sbjct: 244 RLLTKSPKQRITSLQALEHEWF 265 >2I0E-A nrPDB Length = 353 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 126/286 (44%), Gaps = 30/286 (10%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 GN++ +K D +M LG+G++G V + ++ AVK ++ V Q+ D++ Sbjct: 12 GNRD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDD-----DVE 65 Query: 102 ISM---RTVDCP----FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI 154 +M R + P F + ++ ME ++ ++ Q + + + P + Sbjct: 66 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE-PHAV 124 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKTID 213 A I L L SK +I+RD+K NV++++ G +K+ DFG+ + D V Sbjct: 125 F--YAAEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTF 181 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G Y+APE I + Y D W+ G+ + E+ + P++ G +L Q + E Sbjct: 182 CGTPDYIAPEII----AYQPYGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQSIME 235 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKER-PTYPE----LMQHPFF 314 + P S E V + K+ +R PE + +H FF Sbjct: 236 HNVAYPK-SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 280 >2PSQ-A nrPDB Length = 370 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 67/290 (23%), Positives = 123/290 (42%), Gaps = 33/290 (11%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHV-------PSGQIMAVKRIRATVNSQEQKRLLM 98 +E D L LG G +G V V +AVK ++ ++ L+ Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 135 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDI--- 154 ++++ + GA ++G +++ +E +L ++ + G DI Sbjct: 136 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 195 Query: 155 ---------LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL- 204 L + + +E+L S+ IHRD+ NVL+ +K+ DFG++ + Sbjct: 196 PEEQMTFKDLVSCTYQLARGMEYLASQ-KCIHRDLAARNVLVTENNVMKIADFGLARDIN 254 Query: 205 -VDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSW 260 +D KT + G P +MAPE L + Y+ +SD+WS G+ M E+ L PY Sbjct: 255 NIDYYKKTTN-GRLPVKWMAPE----ALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP-- 307 Query: 261 GTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 308 GIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 357 >5AR8-A nrPDB Length = 326 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 66/266 (24%), Positives = 111/266 (41%), Gaps = 25/266 (9%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKR--IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 L RGA G V RH +AVK I + E+K +L + +I + + + Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEI-LHKARFSYILPIL 98 Query: 117 GALFREGDVWICMELM-DTSLDKFYK---QVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 G + I E M + SL++ + D + IL +IA+ + +LH+ Sbjct: 99 GICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV----NYLHNM 154 Query: 173 LS-VIHRDVKPSNVLINALGQVKMCDFGISGYLV------DSVAKTIDAGCKPYMAPERI 225 ++H D+K N+L++ VK+ DFG+S + + S + G YM PE Sbjct: 155 TPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 214 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP-----QLPA 280 P + S+K DI+S + E+ + P++ P Q + V + P LP Sbjct: 215 EPGQKSRA-SIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPY 273 Query: 281 D-KFSAEFVDFTSQCLKKNSKERPTY 305 D A + +N ERP++ Sbjct: 274 DIPHRARMISLIESGWAQNPDERPSF 299 >3PG1-A nrPDB Length = 362 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 48/225 (21%) Query: 125 VWICMELMDTSLDKFYKQVI-DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPS 183 +++ ELM T L QVI D+ I + I+ L LH V+HRD+ P Sbjct: 109 LYLVTELMRTDL----AQVIHDQRIVISPQHIQYFMYHILLGLHVLHEA-GVVHRDLHPG 163 Query: 184 NVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSL 243 N+L+ + +CDF ++ KT + Y APE + + KG++ D+WS Sbjct: 164 NILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPELV---MQFKGFTKLVDMWSA 220 Query: 244 GITMIEL----AILRFPYDSWGTPFQQLKQVVE--------------EPSPQ-------- 277 G M E+ A+ R T + QL ++VE PS + Sbjct: 221 GCVMAEMFNRKALFR-----GSTFYNQLNKIVEVVGTPKIEDVVMFSSPSARDYLRNSLS 275 Query: 278 -LPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFF 314 +PA ++A +D ++ L+ N + R + + ++HP+F Sbjct: 276 NVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 >4X3F-A nrPDB Length = 337 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 41/119 (34%), Positives = 58/119 (48%), Gaps = 23/119 (19%) Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--------- 214 +AL+ H+ ++HRDVKP N+LI GQVK+ DFGI AK +DA Sbjct: 128 RALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGI--------AKAVDAAPVTQTGMV 178 Query: 215 -GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+APE+ L S SD++SLG+ E + P+ G +K + E Sbjct: 179 MGTAQYIAPEQ---ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 233 >4KIK-B nrPDB Length = 677 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 86/200 (43%), Gaps = 15/200 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG G +G V + + +G+ +A+K+ R ++ + ++R +++ I MR + P V Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQI-MRRLTHPNVVAARDV 85 Query: 119 ------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 L + ME + Y + + E + + I AL +LH Sbjct: 86 PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHEN 145 Query: 173 LSVIHRDVKPSNVLINALGQV---KMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 +IHRD+KP N+++ Q K+ D G + L T G Y+APE L Sbjct: 146 -RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL----L 200 Query: 230 NQKGYSVKSDIWSLGITMIE 249 Q+ Y+V D WS G E Sbjct: 201 EQQKYTVTVDYWSFGTLAFE 220 >6B2Q-A nrPDB Length = 317 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 41/119 (34%), Positives = 58/119 (48%), Gaps = 23/119 (19%) Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--------- 214 +AL+ H+ ++HRDVKP N+LI GQVK+ DFGI AK +DA Sbjct: 148 RALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGI--------AKAVDAAPVTQTGMV 198 Query: 215 -GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+APE+ L S SD++SLG+ E + P+ G +K + E Sbjct: 199 MGTAQYIAPEQ---ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 253 >1PY5-A nrPDB Length = 326 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 62/118 (52%), Gaps = 16/118 (13%) Query: 149 TIPEDILGKIAVSIVKALEHLHSKL-------SVIHRDVKPSNVLINALGQVKMCDFGIS 201 T+ + + K+A+S L HLH ++ ++ HRD+K N+L+ G + D G++ Sbjct: 122 TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA 181 Query: 202 GYLVDSVAKTID------AGCKPYMAPERINPELNQKGYSV--KSDIWSLGITMIELA 251 DS TID G K YMAPE ++ +N K + ++DI+++G+ E+A Sbjct: 182 -VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIA 238 >4D2V-A nrPDB Length = 356 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/259 (21%), Positives = 115/259 (44%), Gaps = 15/259 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G G + V+ H+ +G+++A+K + + R+ +++ +++ + Y Sbjct: 37 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIE-ALKNLRHQHICQLYHV 95 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 L +++ +E + + +I + + + E+ + IV A+ ++HS+ HR Sbjct: 96 LETANKIFMVLEYCPGG--ELFDYIISQDR-LSEEETRVVFRQIVSAVAYVHSQ-GYAHR 151 Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--PYMAPERINPELNQKGY-S 235 D+KP N+L + ++K+ DFG+ + + A C Y APE I K Y Sbjct: 152 DLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQG----KSYLG 207 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 ++D+WS+GI + L P+D L + +P S + Q L Sbjct: 208 SEADVWSMGILLYVLMCGFLPFDD--DTAAALVAKIMRGKYDVPK-WLSPSSILLLQQML 264 Query: 296 KKNSKERPTYPELMQHPFF 314 + + K+R + L+ HP+ Sbjct: 265 QVDPKKRISMKNLLNHPWI 283 >3FXW-A nrPDB Length = 336 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 33/273 (12%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG G G V + H +GQ A+K + + ++++ +D + P V Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQE------VDHHWQASGGPHIVCILDV 90 Query: 119 L--FREGD--VWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 173 G + I ME M+ + + ++ ++G Q E +I I A++ LHS Sbjct: 91 YENMHHGKRCLLIIMECMEGG--ELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSH- 147 Query: 174 SVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKP--YMAPERINPE 228 ++ HRDVKP N+L + + +K+ DFG + ++ + C Y+APE + PE Sbjct: 148 NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK---ETTQNALQTPCYTPYYVAPEVLGPE 204 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFP--YDSWGTPFQ-QLKQVVEEPSPQLPADKFSA 285 Y D+WSLG+ M L + FP Y + G +K+ + P ++S Sbjct: 205 ----KYDKSCDMWSLGVIMYIL-LCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSE 259 Query: 286 EFVD---FTSQCLKKNSKERPTYPELMQHPFFT 315 D LK + ER T + M HP+ Sbjct: 260 VSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 292 >5EG3-A nrPDB Length = 334 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 63/277 (22%), Positives = 120/277 (43%), Gaps = 33/277 (11%) Query: 59 LGRGAYGVVEKMRHV-------PSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 LG GA+G V V +AVK ++ ++ L+ ++++ Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 102 Query: 112 TVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDI------------LGKI 158 + GA ++G +++ + +L ++ + G + DI L Sbjct: 103 IINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSC 162 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDAGC 216 + + +E+L S+ IHRD+ NVL+ +K+ DFG++ + +D +T + G Sbjct: 163 TYQLARGMEYLASQ-KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTN-GR 220 Query: 217 KP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEE 273 P +MAPE L + Y+ +SD+WS G+ M E+ L PY G P ++L ++++E Sbjct: 221 LPVKWMAPE----ALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP--GIPVEELFKLLKE 274 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + E C +RPT+ +L++ Sbjct: 275 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVE 311 >4OW8-A nrPDB Length = 283 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 41/119 (34%), Positives = 58/119 (48%), Gaps = 23/119 (19%) Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--------- 214 +AL+ H+ ++HRDVKP N+LI GQVK+ DFGI AK +DA Sbjct: 127 RALQIAHAA-GLVHRDVKPGNILITPTGQVKITDFGI--------AKAVDAAPVTQTGMV 177 Query: 215 -GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+APE+ L S SD++SLG+ E + P+ G +K + E Sbjct: 178 MGTAQYIAPEQ---ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKE 232 >4CQG-A nrPDB Length = 331 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/258 (21%), Positives = 118/258 (45%), Gaps = 15/258 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +G G + V+ HV +G+++A+K + + R+ ++D +++++ Y Sbjct: 17 IGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEID-ALKSLRHQHICQLYHV 75 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 L + +++ +E + + +I + + + E+ + I+ A+ ++HS+ HR Sbjct: 76 LETKNKIFMVLEYCPGG--ELFDYIISQDR-LSEEETRVVFRQILSAVAYVHSQ-GYAHR 131 Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--PYMAPERINPELNQKGY-S 235 D+KP N+L + ++K+ DFG+ + + C Y APE I K Y Sbjct: 132 DLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQG----KSYLG 187 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 ++D+WS+GI + L P+D L + + ++P S + Q L Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDD--DNVMALYKKIMRGKYEVPK-WLSPSSILLLQQML 244 Query: 296 KKNSKERPTYPELMQHPF 313 + + K+R + L+ HP+ Sbjct: 245 QVDPKKRISMRNLLNHPW 262 >3TAC-A nrPDB Length = 361 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 72/285 (25%), Positives = 117/285 (41%), Gaps = 30/285 (10%) Query: 50 ADD---LEPIMEL----GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 ADD E + EL G+G + VV + + +GQ AVK + + L D+ Sbjct: 18 ADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPG--LSTEDL 75 Query: 103 SMRTVDC-----PFTVTFYGALFREGDVWICMELMDTSLDKFYKQV--IDKGQTIPEDIL 155 C P V +G +++ E MD + D ++ V D G E + Sbjct: 76 KREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGA-DLCFEIVKRADAGFVYSEAVA 134 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDS-VAKT 211 I++AL + H ++IHRDVKP VL+ + VK+ FG++ L +S + Sbjct: 135 SHYMRQILEALRYCHDN-NIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAG 193 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G +MAPE + E Y D+W G+ + L P+ +GT + + ++ Sbjct: 194 GRVGTPHFMAPEVVKRE----PYGKPVDVWGCGVILFILLSGCLPF--YGTKERLFEGII 247 Query: 272 EEPSPQLPA--DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + P S D + L + ER T E + HP+ Sbjct: 248 KGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWL 292 >2WTK-C nrPDB Length = 305 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 75/157 (47%), Gaps = 11/157 (7%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL----VDSVAKTIDAGCK 217 ++ LE+LHS+ ++H+D+KP N+L+ G +K+ G++ L D +T G Sbjct: 118 LIDGLEYLHSQ-GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRT-SQGSP 175 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + PE N G+ V DIWS G+T+ + +P++ G +L + + + S Sbjct: 176 AFQPPEIANGLDTFSGFKV--DIWSAGVTLYNITTGLYPFE--GDNIYKLFENIGKGSYA 231 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 +P D D L+ +R + ++ QH +F Sbjct: 232 IPGD-CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF 267 >5O0Y-A nrPDB Length = 579 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 101/238 (42%), Gaps = 19/238 (7%) Query: 105 RTVDCPFTVTFYGALFREGDVW-ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + +D P V Y + D + +E + + FY + + + + E I + IV Sbjct: 343 KELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFY---LKQHKLMSEKEARSIIMQIV 399 Query: 164 KALEHLHS-KLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTID------ 213 AL++L+ K +IH D+KP N+L+ A G++K+ DFG+S + D ++D Sbjct: 400 NALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTS 459 Query: 214 --AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQ 269 AG Y+ PE S K D+WS+G+ + R P+ + Q Sbjct: 460 QGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENT 519 Query: 270 VVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 +++ Q P + E F +CL ++R +L P+ H K +S Sbjct: 520 ILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS 577 >5TOS-A nrPDB Length = 395 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 129/308 (41%), Gaps = 37/308 (12%) Query: 33 LDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV-----EKMRHVPS----GQIMAVKR 83 L S S ++ + P +G G +G V ++ P+ G ++AVK+ Sbjct: 47 LSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 Query: 84 IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQ 142 + Q + L +++ + + P V G + + E M SL+ + Sbjct: 107 LNQE-GFQGHREWLTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR 164 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSK-LSVIHRDVKPSNVLINALGQVKMCDFGIS 201 + +P + +A+ K L LHS + VI+RD+K SN+L++A K+ DFG++ Sbjct: 165 RGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 Query: 202 --GYLVD-SVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIELAILRFPY 257 G + D S T G Y APE ++ LN +SD++S G+ ++E+ + Sbjct: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLN-----ARSDVYSFGVLLLEILSGKRAL 279 Query: 258 D-----------SWGTPFQQLKQ-VVEEPSPQLPADKFSAEFVDFTS---QCLKKNSKER 302 D W P+ K+ V+ +L E V S QCL K R Sbjct: 280 DHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 Query: 303 PTYPELMQ 310 PT ++++ Sbjct: 340 PTMDQVVR 347 >2QKW-B nrPDB Length = 321 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 54/175 (30%), Positives = 87/175 (49%), Gaps = 32/175 (18%) Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS--GYLVDSVA-KTID 213 +I + + L +LH++ ++IHRDVK N+L++ K+ DFGIS G +D T+ Sbjct: 143 EICIGAARGLHYLHTR-AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVV 201 Query: 214 AGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILR------FPYD-----SWG 261 G Y I+PE KG + KSD++S G+ + E+ R P + W Sbjct: 202 KGTLGY-----IDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWA 256 Query: 262 TPFQ---QLKQVVEEPSPQLPADKFSAE----FVDFTSQCLKKNSKERPTYPELM 309 QL+Q+V+ P L ADK E F D +CL +S++RP+ +++ Sbjct: 257 VESHNNGQLEQIVD---PNL-ADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >4PDO-A nrPDB Length = 299 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 66/265 (24%), Positives = 122/265 (46%), Gaps = 29/265 (10%) Query: 59 LGRGAYGVVEK-MRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 +G G +G V K M SG+ +A+K ++A +++ L + I M + Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGI-MGQFSHHNIIR 100 Query: 115 FYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G + + + I E M+ +LDKF ++ G+ ++G + I +++L + + Sbjct: 101 LEGVISKYKPMMIITEYMENGALDKFLRE--KDGEFSVLQLVGMLR-GIAAGMKYL-ANM 156 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKP--YMAPERINPEL 229 + +HRD+ N+L+N+ K+ DFG+S L D T G P + APE I Sbjct: 157 NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI---- 212 Query: 230 NQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEE----PSPQLPADKFS 284 + + ++ SD+WS GI M E+ PY W ++ + + + P+P D S Sbjct: 213 SYRKFTSASDVWSFGIVMWEVMTYGERPY--WELSNHEVMKAINDGFRLPTPM---DCPS 267 Query: 285 AEFVDFTSQCLKKNSKERPTYPELM 309 A + QC ++ RP + +++ Sbjct: 268 AIY-QLMMQCWQQERARRPKFADIV 291 >1TKI-A nrPDB Length = 321 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 64/268 (23%), Positives = 116/268 (43%), Gaps = 29/268 (10%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +LGRG +G+V + S + K ++ Q +L+ +IS+ + + Sbjct: 12 DLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ----VLVKKEISILNIARHRNILHLH 67 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 F + + + + LD F + + +I+ + + +AL+ LHS ++ H Sbjct: 68 ESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVH-QVCEALQFLHSH-NIGH 125 Query: 178 RDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY- 234 D++P N++ +K+ +FG + L K D + APE PE++Q Sbjct: 126 FDIRPENIIYQTRRSSTIKIIEFGQARQL-----KPGDNFRLLFTAPEYYAPEVHQHDVV 180 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPF-----QQLKQVVEEPSPQLPADKF---SAE 286 S +D+WSLG T++ + + S PF QQ+ + + + F S E Sbjct: 181 STATDMWSLG-TLVYVLL------SGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIE 233 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFF 314 +DF + L K K R T E +QHP+ Sbjct: 234 AMDFVDRLLVKERKSRMTASEALQHPWL 261 >4YHJ-A nrPDB Length = 584 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 74/167 (44%), Gaps = 21/167 (12%) Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 A + LE L + +++RD+KP N+L++ G +++ D G++ + + G Sbjct: 293 AAELCCGLEDLQRE-RIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVG 351 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD------SWGTPFQQLKQVVE 272 YMAPE +N N+K Y+ D W LG + E+ P+ W Q++K E Sbjct: 352 YMAPEVVN---NEK-YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTE 407 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 E S +KFS + L KN +R + QHP F Sbjct: 408 EYS-----EKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVF 449 >6EII-A nrPDB Length = 352 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 90/203 (44%), Gaps = 40/203 (19%) Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-VKMCDFGISGYLVD 206 QT+ + + I+KAL++ HS + ++HRDVKP NV+I+ + +++ D+G++ + Sbjct: 149 QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 207 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ 266 + + + PE + ++ + Y D+WSLG + + + P+ + Q Sbjct: 208 GQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 264 Query: 267 LKQVVE----------------EPSPQLP----------ADKF---------SAEFVDFT 291 L ++ + E P+ ++F S E +DF Sbjct: 265 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 324 Query: 292 SQCLKKNSKERPTYPELMQHPFF 314 + L+ + + R T E M+HP+F Sbjct: 325 DKLLRYDHQSRLTAREAMEHPYF 347 >4LFI-A nrPDB Length = 374 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 42/191 (21%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 ++KAL++ HS + ++HRDVKP NV+I+ ++++ D+G++ + ++ + + + Sbjct: 181 LLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK 239 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP----------------- 263 PE + ++ + Y D+WS G + + R P+ GT Sbjct: 240 GPELL---VDYRMYDYSLDLWSFGTMLASMIFKREPFFH-GTSNTDQLVKIVKVLGTSDF 295 Query: 264 --------------FQQLKQVVEEPSPQLPAD-----KFSAEFVDFTSQCLKKNSKERPT 304 F + Q + +P + D + E +D L+ + +ER T Sbjct: 296 EKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT 355 Query: 305 YPELMQHPFFT 315 E M HP+F Sbjct: 356 AKEAMGHPWFA 366 >5TE0-A nrPDB Length = 347 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/149 (30%), Positives = 70/149 (46%), Gaps = 17/149 (11%) Query: 123 GDVWICMELMD----TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH-SKLSVIH 177 GDVW + LMD + Q + G T E+ + +I +A+ LH K +IH Sbjct: 92 GDVWEVLILMDFCRGGQVVNLMNQRLQTGFT--ENEVLQIFCDTCEAVARLHQCKTPIIH 149 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYL--------VDSVAKTIDAGCK-PYMAPERINPE 228 RD+K N+L++ G +CDFG + V++V I Y APE +N Sbjct: 150 RDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNL- 208 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPY 257 + K + K+DIW+LG + +L P+ Sbjct: 209 YSGKIITTKADIWALGCLLYKLCYFTLPF 237 >4K33-A nrPDB Length = 325 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 80/157 (50%), Gaps = 13/157 (8%) Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSVAKTIDAGC 216 A + + +E+L S+ IHRD+ NVL+ +K+ DFG++ + +D +T + G Sbjct: 164 AYQVARGMEYLASQ-KCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTN-GR 221 Query: 217 KP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEE 273 P +MAPE L + Y+ +SD+WS G+ + E+ L PY G P ++L ++++E Sbjct: 222 LPVKWMAPE----ALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYP--GIPVEELFKLLKE 275 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + + +C +RPT+ +L++ Sbjct: 276 GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 312 >5X8I-B nrPDB Length = 346 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 67/240 (27%), Positives = 100/240 (41%), Gaps = 38/240 (15%) Query: 44 QNFEVKADDLEPIMELGRGAYG-VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 Q+ +V + E + LG GA+G VVE + H G+ +AVK ++ E R + + Sbjct: 6 QSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLE 65 Query: 103 SMRTVDCPFT---VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + T D T V G + I EL+ S F K+ + D + K+A Sbjct: 66 HLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE--NGFLPFRLDHIRKMA 123 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVL---------------------INALGQVKMCDF 198 I K++ LHS + H D+KP N+L IN +K+ DF Sbjct: 124 YQICKSVNFLHSN-KLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINP--DIKVVDF 180 Query: 199 GISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE--LAILRFP 256 G + Y D + + Y APE I G+S D+WS+G +IE L FP Sbjct: 181 GSATY--DDEHHSTLVSTRHYRAPEVILA----LGWSQPCDVWSIGCILIEYYLGFTVFP 234 >4E20-A nrPDB Length = 290 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 119/289 (41%), Gaps = 51/289 (17%) Query: 53 LEPIMELGRGAYGVVEKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 L+ I +LG G +G V + P+ G+++AVK ++ Q + +++I +RT+ Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEI-LRTLY 68 Query: 109 CPFTVTFYGALFREGD--VWICMEL--MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 V + G +G+ V + ME + + D + + Q + A I + Sbjct: 69 HEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLL------LFAQQICE 122 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPE- 223 + +LH++ IHR + NVL++ VK+ DFG+ AK + G + Y E Sbjct: 123 GMAYLHAQ-HYIHRALAARNVLLDNDRLVKIGDFGL--------AKAVPEGHEYYRVRED 173 Query: 224 ------RINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP 276 PE L + + SD+WS G+T+ EL DS +P + +++ Sbjct: 174 GDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTY---CDSNQSPHTKFTELIGHTQG 230 Query: 277 QLPA----------------DKFSAEFVDFTSQCLKKNSKERPTYPELM 309 Q+ D+ E C + + RPT+ L+ Sbjct: 231 QMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLV 279 >4MD7-E nrPDB Length = 391 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 90/203 (44%), Gaps = 40/203 (19%) Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-VKMCDFGISGYLVD 206 QT+ + + I+KAL++ HS + ++HRDVKP NV+I+ + +++ D+G++ + Sbjct: 126 QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHP 184 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ 266 + + + PE + ++ + Y D+WSLG + + + P+ + Q Sbjct: 185 GQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQ 241 Query: 267 LKQVVE----------------EPSPQLP----------ADKF---------SAEFVDFT 291 L ++ + E P+ ++F S E +DF Sbjct: 242 LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFL 301 Query: 292 SQCLKKNSKERPTYPELMQHPFF 314 + L+ + + R T E M+HP+F Sbjct: 302 DKLLRYDHQSRLTAREAMEHPYF 324 >4BTF-A nrPDB Length = 469 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 102/219 (46%), Gaps = 20/219 (9%) Query: 103 SMRTVDCPFTVTFYGALFREG----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 +M+ D P + +G + + I ME + ++++D+ + + + + Sbjct: 247 TMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGT---LRELLDREKDLTMSVRSLL 303 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDA-- 214 + + L LH +HR++ S+ L+ QVK+ F +S + AK+ A Sbjct: 304 VLRAARGLYRLHHS-ETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 362 Query: 215 -GCKPYMAPERI-NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 Y++PER+ NP Y +K++I+S GI + E+A + P++ G ++++++V Sbjct: 363 SSSTIYVSPERLKNPFC---LYDIKAEIYSFGIVLWEIATGKIPFE--GCDSKKIRELVA 417 Query: 273 EPSPQLPADKFSAEFV-DFTSQCLKKNSKERPTYPELMQ 310 E Q P + E + + ++C +RP+ +++ Sbjct: 418 EDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >3MDY-A nrPDB Length = 337 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 50/216 (23%), Positives = 98/216 (45%), Gaps = 19/216 (8%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 A ++ + ++G+G YG V + G+ +AVK T + + + + MR + Sbjct: 36 AKQIQMVKQIGKGRYGEVWMGKW--RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN- 92 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 + F A + W + L+ + K T+ + K+A S V L HL Sbjct: 93 --ILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHL 150 Query: 170 HSKL-------SVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDS----VAKTIDAGCK 217 H+++ ++ HRD+K N+L+ G + D G++ ++ D+ + G K Sbjct: 151 HTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 218 PYMAPERINPELNQKGYS--VKSDIWSLGITMIELA 251 YM PE ++ LN+ + + +D++S G+ + E+A Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVA 246 >6HMD-A nrPDB Length = 365 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 84/189 (44%), Gaps = 40/189 (21%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 ++KAL++ HSK ++HRDVKP NV+I + ++++ D+G++ + + + + + Sbjct: 156 LLKALDYCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFK 214 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-----VEEPS 275 PE + ++ + Y D+WSLG + + R P+ + QL ++ EE Sbjct: 215 GPELL---VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 271 Query: 276 PQLPA---------------------DKF---------SAEFVDFTSQCLKKNSKERPTY 305 L + F S E +D + L+ + ++R T Sbjct: 272 GYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTA 331 Query: 306 PELMQHPFF 314 E M+HP+F Sbjct: 332 KEAMEHPYF 340 >4M69-B nrPDB Length = 283 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 47/220 (21%), Positives = 102/220 (46%), Gaps = 20/220 (9%) Query: 103 SMRTVDCPFTVTFYGALFREG----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 +M+ D P + +G + + I ME + ++++D+ + + + + Sbjct: 61 TMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGT---LRELLDREKDLTMSVRSLL 117 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDA-- 214 + + L LH +HR++ S+ L+ QVK+ F +S + AK+ A Sbjct: 118 VLRAARGLYRLHHS-ETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 176 Query: 215 -GCKPYMAPERI-NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 Y++PER+ NP Y +K++I+S GI + E+A + P++ G ++++++V Sbjct: 177 SSSTIYVSPERLKNPFC---LYDIKAEIYSFGIVLWEIATGKIPFE--GCDSKKIRELVA 231 Query: 273 EPSPQLPADKFSAEFV-DFTSQCLKKNSKERPTYPELMQH 311 E Q P + E + + ++C +RP+ +++ Sbjct: 232 EDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILER 271 >5UIU-A nrPDB Length = 323 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 72/285 (25%), Positives = 113/285 (39%), Gaps = 55/285 (19%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN-SQEQKRLLMDLDIS-MRTVDCPFTVTF 115 ++G G +GVV K + +AVK++ A V+ + E+ + D +I M V Sbjct: 54 KMGEGGFGVVYK--GYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 116 YGALFREGDVWICMELM--DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G D+ + M + LD+ +D + + KIA + LH Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRL--SCLDGTPPLSWHMRCKIAQGAANGINFLHENH 169 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGI---SGYLVDSVAKTIDAGCKPYMAPERINPELN 230 IHRD+K +N+L++ K+ DFG+ S +V + G YMAPE + E+ Sbjct: 170 H-IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI- 227 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL------------ 278 + KSDI+S G+ ++E+ G P V E PQL Sbjct: 228 ----TPKSDIYSFGVVLLEIIT--------GLP-----AVDEHREPQLLLDIKEEIEDEE 270 Query: 279 ------------PADKFSAE-FVDFTSQCLKKNSKERPTYPELMQ 310 AD S E SQCL + +RP ++ Q Sbjct: 271 KTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >2I6L-A nrPDB Length = 320 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 74/319 (23%), Positives = 133/319 (41%), Gaps = 74/319 (23%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 DL+P LG G G+V + +A+K+I T + Q K L ++ I +R +D Sbjct: 15 DLKP---LGCGGNGLVFSAVDNDCDKRVAIKKIVLT-DPQSVKHALREIKI-IRRLDHDN 69 Query: 112 TVTFY--------------GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 V + G+L V+I E M+T L V+++G + E Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDL----ANVLEQGPLLEEHA-RL 124 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQV-KMCDFGIS----------GYLVD 206 +++ L+++HS +V+HRD+KP+N+ IN V K+ DFG++ G+L + Sbjct: 125 FMYQLLRGLKYIHSA-NVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSE 183 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ 266 + K Y +P + L+ Y+ D+W+ G E+ + + + +Q Sbjct: 184 GLV------TKWYRSPRLL---LSPNNYTKAIDMWAAGCIFAEMLTGKTLF-AGAHELEQ 233 Query: 267 LKQVVEE------------------------PSPQLPADKF----SAEFVDFTSQCLKKN 298 ++ ++E P P + S E VDF Q L + Sbjct: 234 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFS 293 Query: 299 SKERPTYPELMQHPFFTLH 317 +R T E + HP+ +++ Sbjct: 294 PMDRLTAEEALSHPYMSIY 312 >4YZB-A nrPDB Length = 491 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 95/194 (48%), Gaps = 15/194 (7%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+G++G V + +GQ AVK I + V + K LL+ ++ +D P + Y Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 +G ++ E+ + + ++I + + E +I ++ + ++H K ++H Sbjct: 98 FFEDKGYFYLVTEVYTGG--ELFDEIISR-KRFSEVDAARIIRQVLSGITYMH-KNKIVH 153 Query: 178 RDVKPSNVLINAL---GQVKMCDFGISGYLVDSVAKTIDA-GCKPYMAPERINPELNQKG 233 RD+KP N+L+ +++ DFG+S + +S K D G Y+APE ++ Sbjct: 154 RDLKPENLLLENKRKDANIRIIDFGLSTHF-ESTKKMKDKIGTAYYIAPEVLHGT----- 207 Query: 234 YSVKSDIWSLGITM 247 Y K D+WS G+ + Sbjct: 208 YDEKCDVWSTGVIL 221 >5IKW-A nrPDB Length = 310 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 85/199 (42%), Gaps = 36/199 (18%) Query: 124 DVWICMELMDTS-----LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH-SKLSVIH 177 +VW + LM+ +++ K+ + G T PE + +I +A+ LH K +IH Sbjct: 87 NVWEVLILMEYCRAGQVVNQMNKK-LQTGFTEPEVL--QIFCDTCEAVARLHQCKTPIIH 143 Query: 178 RDVKPSNVLINALGQVKMCDFG--ISGYL------VDSVAKTIDAGCK-PYMAPERINPE 228 RD+K N+L+N G +CDFG + +L V+ V + I Y APE IN Sbjct: 144 RDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINL- 202 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPY-----------------DSWGTPFQQLKQVV 271 K + K+DIW+LG + +L P+ + L + + Sbjct: 203 YGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFM 262 Query: 272 EEPSPQLPADKFSAEFVDF 290 EP P+ D F + F Sbjct: 263 LEPDPEHRPDIFQVSYFAF 281 >3MY0-A nrPDB Length = 305 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 51/192 (26%), Positives = 86/192 (44%), Gaps = 37/192 (19%) Query: 148 QTIPEDILGKIAVSIVKALEHLHSKL-------SVIHRDVKPSNVLINALGQVKMCDFGI 200 QT+ + ++AVS L HLH ++ ++ HRD K NVL+ + Q + D G+ Sbjct: 100 QTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGL 159 Query: 201 -------SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY-SVK-SDIWSLGITMIELA 251 S YL + G K YMAPE ++ ++ + S K +DIW+ G+ + E+A Sbjct: 160 AVMHSQGSDYL--DIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIA 217 Query: 252 ---ILRFPYDSWGTP----------FQQLKQV--VEEPSPQLP----ADKFSAEFVDFTS 292 I+ + + P F+ +K+V V++ +P +P AD + Sbjct: 218 RRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMR 277 Query: 293 QCLKKNSKERPT 304 +C N R T Sbjct: 278 ECWYPNPSARLT 289 >3M42-A nrPDB Length = 299 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 120/274 (43%), Gaps = 57/274 (20%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 115 LG G G V ++ + + + A+K + Q+ + ++++ R CP V Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 79 Query: 116 YGALFR-EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 173 Y L+ + I ME +D + + ++ D+G Q E +I SI +A+++LHS + Sbjct: 80 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-I 136 Query: 174 SVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 ++ HRDVKP N+L NA+ +K+ DFG + ++ + D C Sbjct: 137 NIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAK---ETTGEKYDKSC------------ 179 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFP--YDSWG---TPFQQLKQVV---EEPSPQLPA 280 D+WSLG+ M + + +P Y + G +P + + + E P+P+ Sbjct: 180 ----------DMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW-- 226 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + S E LK +R T E M HP+ Sbjct: 227 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 >5LPZ-A nrPDB Length = 332 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 24/194 (12%) Query: 157 KIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYL--VDS-VAKT 211 KIA+ + L LH S +IHRD+K SNVL++ + ++ DFG++ + +D+ ++ + Sbjct: 121 KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS 180 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 AG Y+ PE S K D++S G+ ++EL + P DS L V Sbjct: 181 TLAGTPGYVPPEY----YQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWV 236 Query: 272 EEPSPQLPADKFSAEF--------------VDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 ++ + +D F E + CL + RPT ++M F + Sbjct: 237 KQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAM-FKEIQ 295 Query: 318 ESKGTDVASFVKLI 331 G D S ++ I Sbjct: 296 AGSGIDSQSTIRSI 309 >4EQM-A nrPDB Length = 294 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 34/122 (27%), Positives = 66/122 (54%), Gaps = 8/122 (6%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD-SVAKTIDA-GCKPY 219 I+ ++H H + ++HRD+KP N+LI++ +K+ DFGI+ L + S+ +T G Y Sbjct: 120 ILDGIKHAHD-MRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQY 178 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +PE+ E + +DI+S+GI + E+ + P++ +K +++ P + Sbjct: 179 FSPEQAKGEATDEC----TDIYSIGIVLYEMLVGEPPFNGETAVSIAIKH-IQDSVPNVT 233 Query: 280 AD 281 D Sbjct: 234 TD 235 >4CRL-A nrPDB Length = 406 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 29/212 (13%) Query: 58 ELGRGAYGVV--EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 ++GRG YG V K + + A+K+I T S R + L R + P ++ Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALL----RELKHPNVISL 84 Query: 116 YGALFREGD--VWICMELMDTSL---DKFYK--QVIDKGQTIPEDILGKIAVSIVKALEH 168 D VW+ + + L KF++ + K +P ++ + I+ + + Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 144 Query: 169 LHSKLSVIHRDVKPSNVLINA----LGQVKMCDFGISGYLVDSVAKTIDAGCKP------ 218 LH+ V+HRD+KP+N+L+ G+VK+ D G + L +S K + A P Sbjct: 145 LHANW-VLHRDLKPANILVMGEGPERGRVKIADMGFAR-LFNSPLKPL-ADLDPVVVTFW 201 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 Y APE + L + Y+ DIW++G EL Sbjct: 202 YRAPELL---LGARHYTKAIDIWAIGCIFAEL 230 >3RP9-A nrPDB Length = 458 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 102/233 (43%), Gaps = 57/233 (24%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMR----TVDCPFTV 113 +G G+YG V + +++A+K+I R + + KR+L ++ I R V + Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 + + ++++ +E+ D+ K ++ + + E + + +++ ++++HS Sbjct: 121 VIPKDVEKFDELYVVLEIADSDFKKLFRTPV----YLTELHIKTLLYNLLVGVKYVHSA- 175 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-------------------- 213 ++HRD+KP+N L+N VK+CDFG+ A+T+D Sbjct: 176 GILHRDLKPANCLVNQDCSVKVCDFGL--------ARTVDYPENGNSQLPISPREDDMNL 227 Query: 214 ----------------AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 + Y APE I L Q+ Y+ D+WS+G EL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELI---LLQENYTEAIDVWSIGCIFAEL 277 >5CLR-A nrPDB Length = 451 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 37/116 (31%), Positives = 63/116 (54%), Gaps = 15/116 (12%) Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212 ++LG I +S+ ++ H +L +IHRD+KP N++++A Q + DFG S D K Sbjct: 177 EVLG-IMISVCHQVKQFH-ELGLIHRDLKPGNIMLDADMQCHLVDFGSSSS--DKEPKPA 232 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLK 268 G Y+APE +N + + +S SD+++L ++ EL PF+Q+K Sbjct: 233 SWGTASYLAPE-LNAQEDFIAFSQVSDLFALAYSLDELF----------NPFRQVK 277 >3LLT-A nrPDB Length = 360 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 97/220 (44%), Gaps = 32/220 (14%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL--DISMRTVDCPFTV 113 I ++G G +G V +H+ + + AVK +R ++ D+ I ++ V Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNNNIV 99 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 ++G + + E + SL + + G I EDI + I+KAL +L K+ Sbjct: 100 KYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHI-EDI-KLYCIEILKALNYL-RKM 156 Query: 174 SVIHRDVKPSNVLIN------ALGQVKMCDFG--ISGYLVDSVA-KTIDAGC-------- 216 S+ H D+KP N+L++ +L V+ G I Y S K ID GC Sbjct: 157 SLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYH 216 Query: 217 ------KPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 + Y APE I LN G+ V SD+WS G + EL Sbjct: 217 GSIINTRQYRAPEVI---LNL-GWDVSSDMWSFGCVLAEL 252 >4OAU-C nrPDB Length = 699 Score = 53.9 bits (128), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 85/211 (40%), Gaps = 39/211 (18%) Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP--EDILGK-IAVSIVKALEHL 169 VTFYG+ G +++C+ L + +L+ + +G+ + ED + + SI KA++ L Sbjct: 398 VTFYGSESHRGHLFVCVTLCEQTLEACLD--VHRGEDVENEEDEFARNVLSSIFKAVQEL 455 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 H H+D++P N+LI++ + DF K+I P Sbjct: 456 HLSCGYTHQDLQPQNILIDSKKAAHLADFD----------KSIKWAGDP----------- 494 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 VK D+ LG ++ + F+ LK E QL D+ E D Sbjct: 495 ----QEVKRDLEDLGRLVL------YVVKKGSISFEDLKAQSNEEVVQLSPDE---ETKD 541 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 + R +L+ HPFF ES+ Sbjct: 542 LIHRLFHPGEHVRDCLSDLLGHPFFWTWESR 572 >2RIO-A nrPDB Length = 434 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/288 (23%), Positives = 126/288 (43%), Gaps = 43/288 (14%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LG G+ G V + G+ +AVKR+ LM++ + + D P + +Y + Sbjct: 23 LGYGSSGTV-VFQGSFQGRPVAVKRMLIDFCDIA----LMEIKLLTESDDHPNVIRYYCS 77 Query: 119 LFREGDVWICMELMDTSLDKFY--KQVIDKGQTI-----PEDILGKIAVSIVKALEHLHS 171 + ++I +EL + +L K V D+ + P +L +IA + HLHS Sbjct: 78 ETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVA----HLHS 133 Query: 172 KLSVIHRDVKPSNVLINALG-------------QVKMCDFGISGYLVDSVAKTID----- 213 L +IHRD+KP N+L++ ++ + DFG+ L DS + Sbjct: 134 -LKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKL-DSGQSSFRTNLNN 191 Query: 214 -AGCKPYMAPERINPELN---QKGYSVKSDIWSLGITMIE-LAILRFPY-DSWGTPFQQL 267 +G + APE + N ++ + DI+S+G L+ + P+ D + + Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNII 251 Query: 268 KQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + + + D+ AE D SQ + + +RPT ++++HP F Sbjct: 252 RGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >3Q4U-A nrPDB Length = 301 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 33/181 (18%) Query: 157 KIAVSIVKALEHLH-------SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-- 207 +I +SI L HLH K ++ HRD+K N+L+ GQ + D G++ S Sbjct: 109 RIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTN 168 Query: 208 ---VAKTIDAGCKPYMAPERINPELNQKGYSV--KSDIWSLGITMIELA---ILRFPYDS 259 V G K YMAPE ++ + + + DIW+ G+ + E+A + + Sbjct: 169 QLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVED 228 Query: 260 WGTP----------FQQLKQV--VEEPSPQLPADKFS----AEFVDFTSQCLKKNSKERP 303 + P F+ +++V V++ P +P FS +C +N R Sbjct: 229 YKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARL 288 Query: 304 T 304 T Sbjct: 289 T 289 >3LMG-A nrPDB Length = 344 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 60/267 (22%), Positives = 116/267 (43%), Gaps = 17/267 (6%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVK---RIRATVNSQEQKRLLMDLDISMR 105 K +L + LG G +G V K +P G+ + + ++ + ++ + + D +++ Sbjct: 29 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIG 88 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 ++D V G + L SL +Q +G P+ +L V I K Sbjct: 89 SLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQ--HRGALGPQLLL-NWGVQIAKG 145 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP---YMAP 222 + +L ++HR++ NVL+ + QV++ DFG++ L + + + K +MA Sbjct: 146 MYYLEEH-GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMAL 204 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVEEPSPQLPAD 281 E I + Y+ +SD+WS G+T+ EL PY G ++ ++E+ Sbjct: 205 ESI----HFGKYTHQSDVWSYGVTVWELMTFGAEPYA--GLRLAEVPDLLEKGERLAQPQ 258 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + +C + RPT+ EL Sbjct: 259 ICTIDVYMVMVKCWMIDENIRPTFKEL 285 >3MIA-A nrPDB Length = 351 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 99/219 (45%), Gaps = 38/219 (17%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLL--------M 98 E + ++G+G +G V K RH +GQ +A+K++ + + + ++L + Sbjct: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 +L RT P+ +G +++ + + L V+ K T+ E + ++ Sbjct: 80 NLIEICRTKASPYNRC-------KGSIYLVFDFCEHDLAGLLSNVLVKF-TLSE--IKRV 129 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-------T 211 ++ L ++H ++HRD+K +NVLI G +K+ DFG++ S+AK T Sbjct: 130 MQMLLNGLYYIHRN-KILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQPNRYT 186 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 Y PE + L ++ Y D+W G M E+ Sbjct: 187 NRVVTLWYRPPELL---LGERDYGPPIDLWGAGCIMAEM 222 >4FL3-A nrPDB Length = 635 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 115/257 (44%), Gaps = 22/257 (8%) Query: 58 ELGRGAYGVVEKMRH--VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 ELG G +G V+K + + +AVK ++ N K L+ M+ +D P+ V Sbjct: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 Query: 116 YGALFREGDVW-ICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G E + W + ME+ + L+K+ +Q + + + + ++ + +++L Sbjct: 436 IGIC--EAESWMLVMEMAELGPLNKYLQQ----NRHVKDKNIIELVHQVSMGMKYLEES- 488 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKP--YMAPERINPEL 229 + +HRD+ NVL+ K+ DFG+S L ++ K G P + APE I Sbjct: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI---- 544 Query: 230 NQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 N +S KSD+WS G+ M E + + PY G ++ ++E+ E Sbjct: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPREMY 602 Query: 289 DFTSQCLKKNSKERPTY 305 D + C + + RP + Sbjct: 603 DLMNLCWTYDVENRPGF 619 >5LPV-A nrPDB Length = 296 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 78/172 (45%), Gaps = 23/172 (13%) Query: 157 KIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYL--VDS-VAKT 211 KIA+ + L LH S +IHRD+K SNVL++ + ++ DFG++ + +D+ ++ + Sbjct: 121 KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS 180 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 AG Y+ PE S K D++S G+ ++EL + P DS L V Sbjct: 181 TLAGTPGYVPPEYY----QSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWV 236 Query: 272 EEPSPQLPADKFSAEF--------------VDFTSQCLKKNSKERPTYPELM 309 ++ + +D F E + CL + RPT ++M Sbjct: 237 KQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVM 288 >5H2U-A nrPDB Length = 267 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/260 (25%), Positives = 118/260 (45%), Gaps = 23/260 (8%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 +LG G +G E + ++ ++ + N Q+ L ++ +M+ + + Y Sbjct: 13 KLGSGYFG--EVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQ-AMKKLRHKHILALYA 69 Query: 118 ALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + V+I ELM SL + + +K +P L IA + + + +L S+ + I Sbjct: 70 VVSVGDPVYIITELMAKGSLLELLRDSDEK--VLPVSELLDIAWQVAEGMCYLESQ-NYI 126 Query: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY--MAPERINPELNQKGY 234 HRD+ N+L+ K+ DFG++ + + V + D PY APE L++ Y Sbjct: 127 HRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNI-PYKWTAPE----ALSRGHY 181 Query: 235 SVKSDIWSLGITMIEL---AILRFPYDSWGTPFQQLKQVVEEPSP-QLPADKFSAEFVDF 290 S KSD+WS GI + E+ + +P S F ++ P P + P S + Sbjct: 182 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPP---SVHKLML 238 Query: 291 TSQCLKKNSKERPTYPELMQ 310 T C ++ ++RPT+ L + Sbjct: 239 TCWC--RDPEQRPTFKALRE 256 >4CRS-A nrPDB Length = 341 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 122/292 (41%), Gaps = 32/292 (10%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA--TVNSQEQKRLL 97 S+ Q F+ D L RG +G V + + ++ A+K ++ V E L+ Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 98 MDLDI--SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 + I ++ +V PF V + + V ME Y D I D+ Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVME---------YAAGGDLMMHIHTDVF 111 Query: 156 GK-----IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK 210 + A +V L++LH +++RD+K N+L++ G VK+ DFG+ + + Sbjct: 112 SEPRAVFYAACVVLGLQYLHEH-KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDR 170 Query: 211 TID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ 269 T G ++APE L + Y+ D W LG+ + E+ + P+ G +++ Sbjct: 171 TSTFCGTPEFLAPEV----LTETSYTRAVDWWGLGVLIYEMLVGESPFP--GDDEEEVFD 224 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPE-----LMQHPFFTL 316 + + P S E + + L++N + R E + +HPFF L Sbjct: 225 SIVNDEVRYPR-FLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRL 275 >6BSD-A nrPDB Length = 876 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/274 (23%), Positives = 113/274 (41%), Gaps = 54/274 (19%) Query: 78 IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-L 136 ++AVK +R + L ++ I R D P + G ++ + + + M+ L Sbjct: 614 LVAVKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLGVCVQDDPLCMITDYMENGDL 672 Query: 137 DKFYK--QVIDK-------------GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181 ++F Q+ DK G TI +L +A I + +L + L+ +HRD+ Sbjct: 673 NQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLA 731 Query: 182 PSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKS 238 N L+ +K+ DFG+S L + P +MA E I L K ++ S Sbjct: 732 TRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECI---LMGK-FTTAS 787 Query: 239 DIWSLGITMIELAILRFPYDSWGTPFQQL--KQVVEEPS---------------PQLPAD 281 D+W+ G+T+ E+ +L PF QL +QV+E P P Sbjct: 788 DVWAFGVTLWEVLML-----CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQG 842 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + +C + S++RP + +L H F Sbjct: 843 LY-----ELMLRCWSRESEQRPPFSQL--HRFLA 869 >6FEX-A nrPDB Length = 321 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 64/268 (23%), Positives = 112/268 (41%), Gaps = 48/268 (17%) Query: 78 IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-L 136 ++AVK +R + L ++ I R D P + G ++ + + + M+ L Sbjct: 59 LVAVKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLGVCVQDDPLCMITDYMENGDL 117 Query: 137 DKFYK--QVIDKGQ-------TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187 ++F Q+ DK TI +L +A I + +L + L+ +HRD+ N L+ Sbjct: 118 NQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRNCLV 176 Query: 188 NALGQVKMCDFGISGYL-VDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLG 244 +K+ DFG+S L + P +MA E I L K ++ SD+W+ G Sbjct: 177 GENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECI---LMGK-FTTASDVWAFG 232 Query: 245 ITMIELAILRFPYDSWGTPFQQL--KQVVEEPS---------------PQLPADKFSAEF 287 +T+ E+ +L PF QL +QV+E P P + Sbjct: 233 VTLWEVLML-----CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLY---- 283 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFT 315 + +C + S++RP + +L H F Sbjct: 284 -ELMLRCWSRESEQRPPFSQL--HRFLA 308 >4JLC-A nrPDB Length = 657 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 88/233 (37%), Gaps = 48/233 (20%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC--------- 109 LG+GA V + RH +G + AVK L +D+ MR + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 68 Query: 110 -------PFTVTFYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 T T + L E G ++ +E + +PE + Sbjct: 69 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------------LPESEFLIV 116 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDA 214 +V + HL ++HRD+KP N++ I GQ K+ DFG + L D Sbjct: 117 LRDVVGGMNHLREN-GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 175 Query: 215 GCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 G + Y+ P+ + +QK Y D+WS+G+T A P+ + P Sbjct: 176 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGP 228 >5C26-A nrPDB Length = 299 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 115/257 (44%), Gaps = 22/257 (8%) Query: 58 ELGRGAYGVVEKMRH--VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 ELG G +G V+K + + +AVK ++ N K L+ M+ +D P+ V Sbjct: 34 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 93 Query: 116 YGALFREGDVW-ICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G E + W + ME+ + L+K+ +Q + + + + ++ + +++L Sbjct: 94 IGIC--EAESWMLVMEMAELGPLNKYLQQ----NRHVKDKNIIELVHQVSMGMKYLEES- 146 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKP--YMAPERINPEL 229 + +HRD+ NVL+ K+ DFG+S L ++ K G P + APE I Sbjct: 147 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI---- 202 Query: 230 NQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 N +S KSD+WS G+ M E + + PY G ++ ++E+ E Sbjct: 203 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPREMY 260 Query: 289 DFTSQCLKKNSKERPTY 305 D + C + + RP + Sbjct: 261 DLMNLCWTYDVENRPGF 277 >4OTD-A nrPDB Length = 341 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 67/279 (24%), Positives = 119/279 (42%), Gaps = 32/279 (11%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA--TVNSQEQKRLLMDLDI--SMRT 106 +D + + LGRG +G V PSG++ A+K ++ V E + L+ + I ++ + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK-----IAVS 161 PF V +G V ME Y D I D+ + + Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVME---------YSAGGDLMLHIHSDVFSEPRAIFYSAC 122 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYM 220 +V L+ LH +++RD+K N+L++ G VK+ DFG+ + +T G ++ Sbjct: 123 VVLGLQFLHEH-KIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFL 181 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 APE L Y+ D W LG+ + E+ + P+ G +++ + + P Sbjct: 182 APE----VLTDTSYTRAVDWWGLGVLLYEMLVGESPFP--GDDEEEVFDSIVNDEVRYPR 235 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPE-----LMQHPFF 314 SAE + + L++N + R E + + PFF Sbjct: 236 -FLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 273 >5XVU-A nrPDB Length = 332 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 29/112 (25%), Positives = 59/112 (52%), Gaps = 5/112 (4%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+KAL++ HS+ ++HRDVKP N++I+ Q+++ +G++ + + + Y Sbjct: 134 ILKALDYCHSQ-GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYK 192 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 PE + ++ + Y DIWSLG + + + P+ + QL ++ + Sbjct: 193 GPELL---IDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAK 241 >6HV0-A nrPDB Length = 416 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 126/274 (45%), Gaps = 36/274 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS--QEQKRLLMDLDISMRTVDCPFTVTFY 116 LG GA G + R + + +AVKRI S + +LL + D + P + ++ Sbjct: 16 LGHGAEGTI-VYRGMFDNRDVAVKRILPECFSFADREVQLLRESD------EHPNVIRYF 68 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 +I +EL +L ++ +Q D E I + L HLHS L+++ Sbjct: 69 CTEKDRQFQYIAIELCAATLQEYVEQK-DFAHLGLEPI--TLLQQTTSGLAHLHS-LNIV 124 Query: 177 HRDVKPSNVLI---NALGQVK--MCDFGISGYLV---DSVAKTIDA-GCKPYMAPERINP 227 HRD+KP N+LI NA G++K + DFG+ L S ++ G + ++APE ++ Sbjct: 125 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 184 Query: 228 ELNQK-GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV------VEEPSPQLPA 280 + + Y+V DI+S G ++ +G Q+ + ++ P+ Sbjct: 185 DCKENPTYTV--DIFSAGCVF--YYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHE 240 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 D + E ++ + + + ++RP+ +++HPFF Sbjct: 241 DVIARELIE---KMIAMDPQKRPSAKHVLKHPFF 271 >2H34-A nrPDB Length = 309 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 107/255 (41%), Gaps = 27/255 (10%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SMRTVDCPFTVTFYG 117 +GRG G V + +I+A+K + T++S R M + + + P V + Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 118 ALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL---EHLHSKL 173 +G +++ M L++ L ++ +G P AV+IV+ + Sbjct: 102 FGEIDGQLYVDMRLINGVDLAAMLRR---QGPLAPPR-----AVAIVRQIGSALDAAHAA 153 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS----VAKTIDAGCKPYMAPERINPEL 229 HRDVKP N+L++A + DFGI+ D + T+ G YMAPER Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTV--GTLYYMAPER----F 207 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 ++ + ++DI++L + E PY D + Q + PS P F Sbjct: 208 SESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPG--IPVAF 265 Query: 288 VDFTSQCLKKNSKER 302 ++ + KN ++R Sbjct: 266 DAVIARGMAKNPEDR 280 >3RAW-A nrPDB Length = 381 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 93/219 (42%), Gaps = 32/219 (14%) Query: 54 EPIMELGRGAYG-VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL--DISMRTVDCP 110 E + LG G +G VVE + H +A+K IR +E RL +++ I + + Sbjct: 54 EIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENK 113 Query: 111 FTVTFYGALFR-EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 F F G + I EL+ + +F K+ + Q P + +A + AL L Sbjct: 114 FLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE--NNFQPYPLPHVRHMAYQLCHALRFL 171 Query: 170 HSKLSVIHRDVKPSNVL-INALGQ------------------VKMCDFGISGYLVDSVAK 210 H + H D+KP N+L +N+ + +++ DFG + + D Sbjct: 172 HEN-QLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF--DHEHH 228 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE 249 T + Y PE I EL G++ D+WS+G + E Sbjct: 229 TTIVATRHYRPPEVI-LEL---GWAQPCDVWSIGCILFE 263 >6FER-A nrPDB Length = 309 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/257 (23%), Positives = 109/257 (42%), Gaps = 41/257 (15%) Query: 78 IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-L 136 ++AVK +RA N + L ++ I R D P + + + + E M+ L Sbjct: 52 LVAVKMLRADANKNARNDFLKEIKIMSRLKD-PNIIHLLAVCITDDPLCMITEYMENGDL 110 Query: 137 DKFYKQ------VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL 190 ++F + +T+ L +A I +++L S L+ +HRD+ N L+ Sbjct: 111 NQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYL-SSLNFVHRDLATRNCLVGKN 169 Query: 191 GQVKMCDFGISGYLVDSVAKTIDA-GCKP--YMAPERINPELNQKGYSVKSDIWSLGITM 247 +K+ DFG+S L I P +M+ E I L K ++ SD+W+ G+T+ Sbjct: 170 YTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESI---LLGK-FTTASDVWAFGVTL 225 Query: 248 IELAILRFPYDSWGTPFQQL--KQVVEE--------------PSPQLPADKFSAEFVDFT 291 E F + P+ QL +QV+E P P + D + Sbjct: 226 WE--TFTFCQEQ---PYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLML--- 277 Query: 292 SQCLKKNSKERPTYPEL 308 C ++++K RP++ E+ Sbjct: 278 -SCWRRDTKNRPSFQEI 293 >6FYV-A nrPDB Length = 337 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 76/330 (23%), Positives = 122/330 (36%), Gaps = 79/330 (23%) Query: 54 EPIMELGRGAYG-VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD---- 108 E + LG GA+G VVE + H G +AVK ++ +E R + + + + D Sbjct: 17 EIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSV 76 Query: 109 --CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 C + ++ G V I EL+ S F K+ + D + ++A I +++ Sbjct: 77 FRCVQMLEWFD---HHGHVCIVFELLGLSTYDFIKE--NSFLPFQIDHIRQMAYQICQSI 131 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQV-------------------KMCDFGISGYLVDS 207 LH + H D+KP N+L V K+ DFG + Y D Sbjct: 132 NFLHHN-KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY--DD 188 Query: 208 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE----------------LA 251 + + Y APE I G+S D+WS+G +IE LA Sbjct: 189 EHHSTLVSTRHYRAPEVILA----LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA 244 Query: 252 ILR-------------------FPYDS--WGTPFQQLKQVVEEPSP----QLPADKFSAE 286 ++ F ++ W + V P L D+ + Sbjct: 245 MMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEK 304 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 D + L+ + +R T E +QHPFF L Sbjct: 305 LFDLVRRMLEYDPTQRITLDEALQHPFFDL 334 >3QUP-A nrPDB Length = 323 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 60/261 (22%), Positives = 106/261 (40%), Gaps = 19/261 (7%) Query: 59 LGRGAYGVV-EKMRHVPSGQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 LG+G +G V E G + AVK ++A + + + M+ D P Sbjct: 31 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKL 90 Query: 116 YGALFR---EGDVWICMELM------DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 G R +G + I M ++ D ++ + +P L + V I + Sbjct: 91 VGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGM 150 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 E+L S+ + IHRD+ N ++ V + DFG+S + GC + + + Sbjct: 151 EYLSSR-NFIHRDLAARNCMLAEDMTVCVADFGLSRKIYS--GDYYRQGCASKLPVKWLA 207 Query: 227 PE-LNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 E L Y+V SD+W+ G+TM E+ + PY G ++ + + + Sbjct: 208 LESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYA--GIENAEIYNYLIGGNRLKQPPECM 265 Query: 285 AEFVDFTSQCLKKNSKERPTY 305 E D QC + K+RP++ Sbjct: 266 EEVYDLMYQCWSADPKQRPSF 286 >4EUT-A nrPDB Length = 396 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 88/233 (37%), Gaps = 48/233 (20%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC--------- 109 LG+GA V + RH +G + A+K L +D+ MR + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 69 Query: 110 -------PFTVTFYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 T T + L E G ++ +E + +PE + Sbjct: 70 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------------LPESEFLIV 117 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDA 214 +V + HL ++HR++KP N++ I GQ K+ DFG + L D Sbjct: 118 LRDVVGGMNHLREN-GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 176 Query: 215 GCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 G + Y+ P+ + +QK Y D+WS+G+T A P+ + P Sbjct: 177 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 229 >6NT9-A nrPDB Length = 742 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 88/233 (37%), Gaps = 48/233 (20%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC--------- 109 LG+GA V + RH +G + A+K L +D+ MR + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 67 Query: 110 -------PFTVTFYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 T T + L E G ++ +E + +PE + Sbjct: 68 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------------LPESEFLIV 115 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDA 214 +V + HL ++HR++KP N++ I GQ K+ DFG + L D Sbjct: 116 LRDVVGGMNHLREN-GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLY 174 Query: 215 GCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 G + Y+ P+ + +QK Y D+WS+G+T A P+ + P Sbjct: 175 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 227 >3PLS-A nrPDB Length = 298 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 67/317 (21%), Positives = 127/317 (40%), Gaps = 38/317 (11%) Query: 31 RDLDSKAC-----ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ--IMAVKR 83 RDLDS + I ++ +D + +G+G +GVV ++ Q I + Sbjct: 1 RDLDSALLAEVKDVLIPHERVVTHSDRV-----IGKGHFGVVYHGEYIDQAQNRIQCAIK 55 Query: 84 IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR-EGDVWICMELM-DTSLDKFYK 141 + + +Q + + MR ++ P + G + EG + + M L +F + Sbjct: 56 SLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIR 115 Query: 142 QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS 201 + T+ + I + + + +E+L ++ +HRD+ N +++ VK+ DFG++ Sbjct: 116 SP-QRNPTVKDLI--SFGLQVARGMEYL-AEQKFVHRDLAARNCMLDESFTVKVADFGLA 171 Query: 202 GYLVDSVAKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSW 260 ++D ++ + + E L ++ KSD+WS G+ + EL P Sbjct: 172 RDILDREYYSVQQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRH 231 Query: 261 GTPF---QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 PF L Q P P+ D QC + + RPT+ L+ Sbjct: 232 IDPFDLTHFLAQGRRLPQPEYCPDS----LYQVMQQCWEADPAVRPTFRVLV-------- 279 Query: 318 ESKGTDVASFVKLILGD 334 +V V +LGD Sbjct: 280 ----GEVEQIVSALLGD 292 >4MWI-A nrPDB Length = 294 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 14/166 (8%) Query: 155 LGKIAVSIVKALEHL----HSKLSVIHRDVKPSNVLINALGQVKMCDFGI-----SGYLV 205 LGK V ++ A L HS+ +H ++ SN L+ QVK+ F + S L Sbjct: 126 LGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLG 185 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 + KT Y++P+ + Q Y VKS+I+S GI + E+A P+ G + Sbjct: 186 TTREKTDRVKSTAYLSPQELEDVFYQ--YDVKSEIYSFGIVLWEIATGDIPFQ--GCNSE 241 Query: 266 QLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 +++++V Q P + +E + +C + RP+ E+++ Sbjct: 242 KIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 >2JD5-A nrPDB Length = 373 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 88/195 (45%), Gaps = 25/195 (12%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + E++ +L K+ +G IP + +I+ ++ L+++H + +IH D+KP NVL Sbjct: 107 MVFEVLGENLLALIKKYEHRG--IPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVL 164 Query: 187 I------NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 + L Q+K+ D G + + + +I + Y +PE L + +DI Sbjct: 165 MEIVDSPENLIQIKIADLGNACWYDEHYTNSIQT--REYRSPEV----LLGAPWGCGADI 218 Query: 241 WSLGITMIELAILRFPYD-----SWGTPFQQLKQVV----EEPSPQLPADKFSAEFVDFT 291 WS + EL F ++ S+ + Q++ E PS L K++ F F Sbjct: 219 WSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTF--FN 276 Query: 292 SQCLKKNSKERPTYP 306 S+ L +N + +P Sbjct: 277 SRGLLRNISKLKFWP 291 >2WO6-A nrPDB Length = 382 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 106/235 (45%), Gaps = 15/235 (6%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR---ATVNSQEQKRLLMDL 100 +N E D E +G+G++G V K + +A+K I+ A +N + + L++L Sbjct: 47 KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLEL 106 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 T + V + + E++ +L + +G ++ ++ K A Sbjct: 107 MNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSL--NLTRKFAQ 164 Query: 161 SIVKALEHLHS-KLSVIHRDVKPSNVLIN--ALGQVKMCDFGISGYLVDSVAKTIDAGCK 217 + AL L + +LS+IH D+KP N+L+ +K+ DFG S L + + I + + Sbjct: 165 QMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQS--R 222 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 Y +PE L Y + D+WSLG ++E+ P S Q+ ++VE Sbjct: 223 FYRSPE----VLLGMPYDLAIDMWSLGCILVEMHTGE-PLFSGANEVDQMNKIVE 272 >4EUU-A nrPDB Length = 319 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 9/122 (7%) Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLV 205 +PE + +V + HL ++HR++KP N++ I GQ K+ DFG + L Sbjct: 109 LPESEFLIVLRDVVGGMNHLREN-GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELE 167 Query: 206 DSVAKTIDAGCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWG 261 D G + Y+ P+ + +QK Y D+WS+G+T A P+ + Sbjct: 168 DDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE 227 Query: 262 TP 263 P Sbjct: 228 GP 229 >6O8B-A nrPDB Length = 665 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 88/233 (37%), Gaps = 48/233 (20%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC--------- 109 LG+GA V + RH +G + A+K L +D+ MR + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNI-------SFLRPVDVQMREFEVLKKLNHKNI 75 Query: 110 -------PFTVTFYGALFRE----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 T T + L E G ++ +E + +PE + Sbjct: 76 VKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYG------------LPESEFLIV 123 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDA 214 +V + HL ++HR++KP N++ I GQ K+ DFG + L D Sbjct: 124 LRDVVGGMNHLREN-GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELY 182 Query: 215 GCKPYMAPERINPEL----NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 G + Y+ P+ + +QK Y D+WS+G+T A P+ + P Sbjct: 183 GTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGP 235 >3AOX-A nrPDB Length = 344 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 65/279 (23%), Positives = 114/279 (40%), Gaps = 20/279 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEK-----MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 EV ++ I LG GA+G V + M + PS +AVK + + Q++ LM+ Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 102 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI----LGK 157 I + + V G + +I +ELM K + + + P + L Sbjct: 103 I-ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 161 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI--DAG 215 +A I ++L IHRD+ N L+ G ++ G G D + G Sbjct: 162 VARDIACGCQYLEEN-HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGG 220 Query: 216 CKPYMAPER-INPELNQKG-YSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVE 272 C M P + + PE +G ++ K+D WS G+ + E+ L + PY S Q++ + V Sbjct: 221 CA--MLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSN--QEVLEFVT 276 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 P +QC + ++RP + +++ Sbjct: 277 SGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER 315 >2CMW-A nrPDB Length = 310 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 95/213 (44%), Gaps = 27/213 (12%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + +EL+ SL+ + + D+ T+ ++ IA+ ++ +E++HSK ++I+RDVKP N L Sbjct: 74 MVLELLGPSLEDLF-DLCDRTFTLKTVLM--IAIQLLSRMEYVHSK-NLIYRDVKPENFL 129 Query: 187 INALGQ-----VKMCDFGISGYLVDSVAKTID--------AGCKPYMAPERINPELNQKG 233 I G + + DFG++ +D K G YM+ IN L ++ Sbjct: 130 IGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS---INTHLGKEQ 186 Query: 234 YSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 S + D+ +LG + P+ D+ +Q++ + + F E Sbjct: 187 -SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMA 245 Query: 289 DFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 + + + E+P Y E ++ F L E KG Sbjct: 246 TYLRYVRRLDFFEKPDY-EYLRTLFTDLFEKKG 277 >3SOC-A nrPDB Length = 322 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/261 (22%), Positives = 114/261 (43%), Gaps = 38/261 (14%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98 + +G +N ++ L+ + RG +G V K + + + + I+ + Q + + Sbjct: 12 VDLGTENLYFQSMPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVY- 70 Query: 99 DLDISMRTVDCPFTVTFYGALFR----EGDVWICMELMDT-SLDKFYKQVIDKGQTIPED 153 S+ + + F GA R + D+W+ + SL F K + + Sbjct: 71 ----SLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLK-----ANVVSWN 121 Query: 154 ILGKIAVSIVKALEHLHSKL---------SVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 L IA ++ + L +LH + ++ HRD+K NVL+ + DFG++ L Sbjct: 122 ELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLA--L 179 Query: 205 VDSVAKTI-----DAGCKPYMAPERINPELN-QKGYSVKSDIWSLGITMIELA----ILR 254 K+ G + YMAPE + +N Q+ ++ D++++G+ + ELA Sbjct: 180 KFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAAD 239 Query: 255 FPYDSWGTPFQQLKQVVEEPS 275 P D + PF++ ++ + PS Sbjct: 240 GPVDEYMLPFEE--EIGQHPS 258 >5HLW-A nrPDB Length = 299 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 94/202 (46%), Gaps = 19/202 (9%) Query: 59 LGRGAYGVVEKMRHVPS-GQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +GRG +G V + + G+ + AVK + + E + L + I M+ P ++ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTE-GIIMKDFSHPNVLSL 86 Query: 116 YGALFR-EGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G R EG + + M L F + + +D++G + + K +++L SK Sbjct: 87 LGICLRSEGSPLVVLPYMKHGDLRNFIRN--ETHNPTVKDLIG-FGLQVAKGMKYLASK- 142 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCK---PYMAPERINPE 228 +HRD+ N +++ VK+ DFG++ + D ++ G K +MA E Sbjct: 143 KFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALE----S 198 Query: 229 LNQKGYSVKSDIWSLGITMIEL 250 L + ++ KSD+WS G+ + EL Sbjct: 199 LQTQKFTTKSDVWSFGVLLWEL 220 >4L00-A nrPDB Length = 304 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 68/277 (24%), Positives = 112/277 (40%), Gaps = 47/277 (16%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF------- 111 LGRG H+ SG +M K T ++ K +L LD S R + F Sbjct: 33 LGRGT------RTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMM 86 Query: 112 -------TVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIV 163 V YG R+ + + E ++ LD F + K + K+A + Sbjct: 87 RQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHR---KSDVLTTPWKFKVAKQLA 143 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQ-------VKMCDFGISGYLVDSVAKTIDAGC 216 AL +L K ++H +V N+L+ G +K+ D GI V S + I+ Sbjct: 144 SALSYLEDK-DLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIP-ITVLSRQECIER-- 199 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE--- 273 P++APE + + K SV +D WS G T+ E+ Y+ P + + +E Sbjct: 200 IPWIAPECVE---DSKNLSVAADKWSFGTTLWEIC-----YNG-EIPLKDKTLIEKERFY 250 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 S P E D ++C+ + +RP + +M+ Sbjct: 251 ESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMR 287 >3UIM-A nrPDB Length = 326 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 54/233 (23%), Positives = 98/233 (42%), Gaps = 37/233 (15%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 + +V +D+ LGRG +G V K R + G ++AVKR++ + + ++++ Sbjct: 23 RELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGELQFQTEVEMI 81 Query: 104 MRTVD-----------CPFTVTFYGALFREGDVWICMELMDTS---LDKFYKQVIDKGQT 149 V P G V C+ S LD +Q Sbjct: 82 SMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQ------- 134 Query: 150 IPEDILGKIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYL--V 205 +IA+ + L +LH +IHRDVK +N+L++ + + DFG++ + Sbjct: 135 -------RIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYK 187 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD 258 D+ T G ++APE L+ S K+D++ G+ ++EL + +D Sbjct: 188 DTHVTTAVRGTIGHIAPEY----LSTGKSSEKTDVFGYGVMLLELITGQRAFD 236 >4IAN-A nrPDB Length = 358 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 94/200 (47%), Gaps = 20/200 (10%) Query: 60 GRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP-----FTV 113 G+G + V + R + + Q +AVK IR N QK L +L+ + D + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRN--NELMQKTGLKELEFLKKLNDADPDDKFHCL 96 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS--IVKALEHLHS 171 + + + + + E + +L + K+ G+ + I + S + AL+ L Sbjct: 97 RLFRHFYHKQHLCLVFEPLSMNLREVLKKY---GKDVGLHIKAVRSYSQQLFLALKLL-K 152 Query: 172 KLSVIHRDVKPSNVLINALGQV-KMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 + +++H D+KP N+L+N + K+CDFG + ++ D+ T + Y APE I Sbjct: 153 RCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDI-TPYLVSRFYRAPEIIIG--- 208 Query: 231 QKGYSVKSDIWSLGITMIEL 250 K Y D+WS+G T+ EL Sbjct: 209 -KSYDYGIDMWSVGCTLYEL 227 >3GC0-A nrPDB Length = 329 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 92/222 (41%), Gaps = 26/222 (11%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-----VNSQEQKRLLMDLDISMR 105 D I +LG G YG V K + + +A+KRIR V + + + ++ R Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + + + + + E + L K+ +DK + ++ ++ Sbjct: 94 NI-----IELKSVIHHNHRLHLIFEYAENDLKKY----MDKNPDVSMRVIKSFLYQLING 144 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQ-----VKMCDFGIS-GYLVDSVAKTIDAGCKPY 219 + HS+ +HRD+KP N+L++ +K+ DFG++ + + T + Y Sbjct: 145 VNFCHSR-RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWY 203 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDS 259 PE + L + YS DIWS+ E+ + FP DS Sbjct: 204 RPPEIL---LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDS 242 >3ZBF-A nrPDB Length = 322 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 117/271 (43%), Gaps = 37/271 (13%) Query: 59 LGRGAYGVVEK-----MRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 LG GA+G V + + V SG+I +AVK ++ QE+ L + + M + P Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHL-MSKFNHPNI 99 Query: 113 VTFYGALFREGDVWICMELMD-----TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + G +I +ELM+ T L K + G + L + V I K Sbjct: 100 LKQLGVCLLNEPQYIILELMEGGDLLTYLRK-ARMATFYGPLLTLVDLVDLCVDISKGCV 158 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLV-DSVAKTIDAGCKP--Y 219 +L ++ IHRD+ N L++ VK+ DFG++ + + + G P + Sbjct: 159 YL-ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW 217 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVE----EP 274 MAPE + + ++ +SD+WS GI + E+ L PY + + L V EP Sbjct: 218 MAPESLMDGI----FTTQSDVWSFGILIWEILTLGHQPYPA-HSNLDVLNYVQTGGRLEP 272 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 P D + + +QC + +RPT+ Sbjct: 273 PRNCPDDLW-----NLMTQCWAQEPDQRPTF 298 >4PL5-B nrPDB Length = 435 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 123/271 (45%), Gaps = 30/271 (11%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS--QEQKRLLMDLDISMRTVDCPFTVTFY 116 LG GA G + + + + +AVKRI S + +LL + D + P + ++ Sbjct: 35 LGHGAEGTI-VYKGMFDNRDVAVKRILPECFSFADREVQLLRESD------EHPNVIRYF 87 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 +I +EL +L ++ +Q D E I + L HLHS L+++ Sbjct: 88 CTEKDRQFQYIAIELCAATLQEYVEQK-DFAHLGLEPI--TLLHQTTSGLAHLHS-LNIV 143 Query: 177 HRDVKPSNVLI---NALGQVK--MCDFGISGYLV---DSVAKTIDA-GCKPYMAPERINP 227 HRD+KP N+L+ NA G++K + DFG+ L S ++ G + ++APE ++ Sbjct: 144 HRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 203 Query: 228 EL-NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ--LPADKFS 284 + + Y+V DI+S G ++ Y +G Q+ ++ +DK Sbjct: 204 DCKDNPTYTV--DIFSAGCVF--YYVISEGYHPFGKSLQRQANILLGACNLDCFHSDKHE 259 Query: 285 AEFV-DFTSQCLKKNSKERPTYPELMQHPFF 314 + + + + ++RP+ +++HPFF Sbjct: 260 DVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >3C1X-A nrPDB Length = 373 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 93/202 (46%), Gaps = 19/202 (9%) Query: 59 LGRGAYGVVEKMRHVPS-GQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 +GRG +G V + + G+ + AVK + + E + L + I M+ P ++ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTE-GIIMKDFSHPNVLSL 155 Query: 116 YGALFR-EGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 G R EG + + M L F + + +D++G + + K ++ L SK Sbjct: 156 LGICLRSEGSPLVVLPYMKHGDLRNFIRN--ETHNPTVKDLIG-FGLQVAKGMKFLASK- 211 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCK---PYMAPERINPE 228 +HRD+ N +++ VK+ DFG++ + D ++ G K +MA E Sbjct: 212 KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALE----S 267 Query: 229 LNQKGYSVKSDIWSLGITMIEL 250 L + ++ KSD+WS G+ + EL Sbjct: 268 LQTQKFTTKSDVWSFGVLLWEL 289 >4NFN-A nrPDB Length = 309 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 54/275 (19%), Positives = 121/275 (44%), Gaps = 21/275 (7%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 N+ VK D + + ++G G +G + + + + + +A+K V S +Q + ++ +++++ Sbjct: 16 NYVVK-DRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAV 69 Query: 105 --RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + F G E ++ M+L +L + T+ + ++ I Sbjct: 70 LKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTL--RLGKQI 127 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINAL----GQVKMCDFGISGYLVDSVAKTID----A 214 ++++E +HS + +HRD+KPSN + L + M DFG++ ++ A Sbjct: 128 LESIEAIHS-VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVA 186 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G + + +N N++ D+WSL ++E A+ + P+ +Q+ + E+ Sbjct: 187 GFRGTVRYASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKEKY 244 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 ++ +EF F + +P Y +M Sbjct: 245 EHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIM 279 >5M07-A nrPDB Length = 276 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 105/252 (41%), Gaps = 41/252 (16%) Query: 59 LGRGAYGVVEKMRH--VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG A G V ++H P Q + V + + ++R + +++ R P + + Sbjct: 38 LGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFH-PHILEVH 96 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 +G +WI M+ +D +D +P + I ++ AL++ H + ++ Sbjct: 97 DRGEFDGQLWIAMDYVD-GIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQR-GLL 154 Query: 177 HRDVKPSNVLINALG----QVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQK 232 HRDV P+NV++ + ++ + DFGI A Y APE ++ + Sbjct: 155 HRDVNPANVVLTSQSAGDQRILLADFGI-------------ASQPSYPAPE-LSAGADVD 200 Query: 233 GYSVKSDIWSLGITMIELAILRFPYDSWGT-PFQ------------QLKQVVEEPSPQLP 279 G ++D ++L +T I L P D T P Q +L V+ P Sbjct: 201 G---RADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLSRALATAP 257 Query: 280 ADKFSA--EFVD 289 AD+F + EF D Sbjct: 258 ADRFGSCREFAD 269 >4M66-A nrPDB Length = 325 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 76/160 (47%), Gaps = 13/160 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107 V ++L+ + +G+G +GVV + H +AVK + + S E K + +++R Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAM-----VNLRNE 71 Query: 108 DCPFTVTFYGAL---FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + L F G + + + SL + + P +L ++ +V Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR----PWPLLCRLLQEVVL 127 Query: 165 ALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISGY 203 + +LHS ++HRD+KPSN+L++ K+ DFG+S + Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTF 167 >4BTK-A nrPDB Length = 337 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 54/275 (19%), Positives = 121/275 (44%), Gaps = 21/275 (7%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 N+ VK D + + ++G G +G + + + + + +A+K V S +Q + ++ +++++ Sbjct: 51 NYVVK-DRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-----VESAQQPKQVLKMEVAV 104 Query: 105 --RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + F G E ++ M+L +L + T+ + ++ I Sbjct: 105 LKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTL--RLGKQI 162 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINAL----GQVKMCDFGISGYLVDSVAKTID----A 214 ++++E +HS + +HRD+KPSN + L + M DFG++ ++ A Sbjct: 163 LESIEAIHS-VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVA 221 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G + + +N N++ D+WSL ++E A+ + P+ +Q+ + E+ Sbjct: 222 GFRGTVRYASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKEKY 279 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 ++ +EF F + +P Y +M Sbjct: 280 EHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIM 314 >4CI6-B nrPDB Length = 643 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 62/237 (26%), Positives = 95/237 (40%), Gaps = 38/237 (16%) Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI---AVSIVKALEHLHS 171 +Y L E D W C + + SL +KQ G+ E G I A ++ HL + Sbjct: 120 YYALLMDEVDGWRCSDTL-RSLADSWKQ----GKINSEAYWGTIKFIAHRLLDVTNHL-A 173 Query: 172 KLSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN-PEL 229 K ++H D+KP NV+ + A G+ + D G+ +G +P E PEL Sbjct: 174 KAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSR----------SGEQPKGFTESFKAPEL 223 Query: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF---- 283 G S KSD++ + T++ I F D P Q L+ + EP+ + + + Sbjct: 224 GVGNLGASEKSDVFLVVSTLLH-GIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHR 282 Query: 284 ------SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 + F + L ++ RP E H F S GT K IL D Sbjct: 283 PGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFL----SDGTIDEESAKQILKD 335 >2QLU-A nrPDB Length = 314 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 71/151 (47%), Gaps = 26/151 (17%) Query: 146 KGQTIPEDILGKIAVSIVKALEHLHS----------KLSVIHRDVKPSNVLINALGQVKM 195 KG I + L +A ++ + L +LH K S+ HRD K NVL+ + + Sbjct: 105 KGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVL 164 Query: 196 CDFGISGYLV------DSVAKTIDAGCKPYMAPERINPELN-QKGYSVKSDIWSLGITMI 248 DFG++ D+ + G + YMAPE + +N Q+ ++ D++++G+ + Sbjct: 165 ADFGLAVRFEPGKPPGDTHGQV---GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLW 221 Query: 249 ELA----ILRFPYDSWGTPFQQLKQVVEEPS 275 EL P D + PF++ ++ + PS Sbjct: 222 ELVSRCKAADGPVDEYMLPFEE--EIGQHPS 250 >5WNO-A nrPDB Length = 330 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 7/104 (6%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYM 220 I +++L K V+HRD+ NVL+ V++ DFG+S L D+ + TI +G + Sbjct: 133 IASGMQYL-EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSG---KV 188 Query: 221 APERINPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGT 262 A + + E+ K Y+ SD+W+ G+T E+ + PY T Sbjct: 189 AIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMST 232 >5UNP-A nrPDB Length = 369 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 96/222 (43%), Gaps = 32/222 (14%) Query: 54 EPIMELGRGAYG-VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL--DISMRTVDCP 110 E + LG G +G VV+ + H G +A+K I+ +E RL +++ I+ + D Sbjct: 37 EIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNK 96 Query: 111 -FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V + G + I EL+ S F K + P + +A + +A++ L Sbjct: 97 NLCVQMFDWFDYHGHMCISFELLGLSTFDFLKD--NNYLPYPIHQVRHMAFQLCQAVKFL 154 Query: 170 HSKLSVIHRDVKPSNVL-INALGQ------------------VKMCDFGISGYLVDSVAK 210 H + H D+KP N+L +N+ + V++ DFG + + D Sbjct: 155 HDN-KLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF--DHEHH 211 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 + + Y APE I EL G+S D+WS+G + E + Sbjct: 212 STIVSTRHYRAPEVI-LEL---GWSQPCDVWSIGCIIFEYYV 249 >3G2F-A nrPDB Length = 336 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/193 (25%), Positives = 82/193 (42%), Gaps = 43/193 (22%) Query: 157 KIAVSIVKALEHLHSKL--------SVIHRDVKPSNVLINALGQVKMCDFGISGYLV--- 205 ++A S+ + L +LH++L ++ HRD+ NVL+ G + DFG+S L Sbjct: 115 RLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNR 174 Query: 206 ------DSVAKTIDAGCKPYMAPERINPELNQKGYSV---KSDIWSLGITMIELAILR-- 254 + A + G YMAPE + +N + + D+++LG+ E+ +R Sbjct: 175 LVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEI-FMRCT 233 Query: 255 --FPYDS---WGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 FP +S + FQ +V P+ F D Q L K+RP +PE Sbjct: 234 DLFPGESVPEYQMAFQ--TEVGNHPT-----------FEDM--QVLVSREKQRPKFPEAW 278 Query: 310 QHPFFTLHESKGT 322 + + K T Sbjct: 279 KENSLAVRSLKET 291 >4TN6-A nrPDB Length = 318 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 124/276 (44%), Gaps = 41/276 (14%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT-VDCPFTVTFY 116 ++G G++G + + +G+ +A+K + Q + + M+ V P T+ + Sbjct: 14 KIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGVGIP-TIRWC 71 Query: 117 GALFREGDVWI-CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 GA EGD + MEL+ SL+ + + ++ +L +A ++ +E++HSK + Sbjct: 72 GA---EGDYNVMVMELLGPSLEDLF-NFCSRKFSLKTVLL--LADQMISRIEYIHSK-NF 124 Query: 176 IHRDVKPSNVLINALGQ----VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 IHRDVKP N L+ LG+ V + DFG++ K DA ++ P R N L Sbjct: 125 IHRDVKPDNFLM-GLGKKGNLVYIIDFGLA-------KKYRDARTHQHI-PYRENKNLTG 175 Query: 232 KGY------------SVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEE--PS 275 S + D+ SLG ++ + P+ T Q+ +++ E+ + Sbjct: 176 TARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMST 235 Query: 276 P-QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P ++ + +EF + + C ++P Y L Q Sbjct: 236 PIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQ 271 >5U6C-A nrPDB Length = 315 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 75/177 (42%), Gaps = 17/177 (9%) Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 Y ++ + IP L K V I +E+L ++ + +HRD+ N ++ V + DF Sbjct: 135 LYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNR-NFLHRDLAARNCMLRDDMTVCVADF 193 Query: 199 GISGYLVDSVAKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPY 257 G+S + G M + I E L + Y+ KSD+W+ G+TM E+A Sbjct: 194 GLSKKIYS--GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGM-- 249 Query: 258 DSWGTPF------QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 TP+ + ++ + P D E + C + + +RPT+ L Sbjct: 250 ----TPYPGVQNHEMYDYLLHGHRLKQPEDCLD-ELYEIMYSCWRTDPLDRPTFSVL 301 >4F9B-A nrPDB Length = 361 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 60/142 (42%), Gaps = 34/142 (23%) Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTID----- 213 +++ KAL+ +H + ++HRDVKPSN L N L + + DFG++ D+ + + Sbjct: 124 LNLFKALKRIH-QFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSE 182 Query: 214 ------------------------AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE 249 AG + APE + NQ + D+WS G+ + Sbjct: 183 AQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQ---TTAIDMWSAGVIFLS 239 Query: 250 LAILRFPYDSWGTPFQQLKQVV 271 L R+P+ L Q++ Sbjct: 240 LLSGRYPFYKASDDLTALAQIM 261 >2C47-A nrPDB Length = 313 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 45/200 (22%), Positives = 89/200 (44%), Gaps = 26/200 (13%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + +EL+ SL+ + + D+ T+ ++ IA+ ++ +E++H+K S+I+RDVKP N L Sbjct: 77 MVLELLGPSLEDLF-DLCDRTFTLKTVLM--IAIQLITRMEYVHTK-SLIYRDVKPENFL 132 Query: 187 INALGQ-----VKMCDFGISGYLVDSVAKTID--------AGCKPYMAPERINPELNQKG 233 + G + + DFG++ +D K G YM+ IN L ++ Sbjct: 133 VGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS---INTHLGKEQ 189 Query: 234 YSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 S + D+ +LG + P+ D+ +Q++ ++ + F E Sbjct: 190 -SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMA 248 Query: 289 DFTSQCLKKNSKERPTYPEL 308 + + + E+P Y L Sbjct: 249 TYLRYVRRLDFFEKPDYDYL 268 >5KMM-A nrPDB Length = 329 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 98/234 (41%), Gaps = 29/234 (12%) Query: 35 SKACISIGNQNFEVKADDLEPIMELGRGAYGVV---EKMRHVPSGQIMAVKRIRATVNSQ 91 S AC+ +K D+ ELG GA+G V E +P M V ++A + Sbjct: 25 SDACVH------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA-VKALKEAS 77 Query: 92 EQKRLLMDLDISMRT-VDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYK------QV 143 E R + + T + V F+G + + E M L++F + ++ Sbjct: 78 ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKL 137 Query: 144 IDKGQTIPEDILG-----KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 + G+ + LG +A + + +L + L +HRD+ N L+ VK+ DF Sbjct: 138 LAGGEDVAPGPLGLGQLLAVASQVAAGMVYL-AGLHFVHRDLATRNCLVGQGLVVKIGDF 196 Query: 199 GISGYLVDSVAKTIDAGCKPYMAPERINP--ELNQKGYSVKSDIWSLGITMIEL 250 G+S + + + M P R P + + ++ +SD+WS G+ + E+ Sbjct: 197 GMSRDIYSTDYYRVGGRT---MLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 247 >6DC0-A nrPDB Length = 292 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/106 (26%), Positives = 50/106 (47%), Gaps = 17/106 (16%) Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQ--- 269 GC Y++PE +N G + +D+WSLG+ + L + R+P+ F ++++ Sbjct: 161 GCPAYVSPEILNTTGTYSGKA--ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQF 218 Query: 270 -VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + E SP+ L++ ER T PE++ HP+F Sbjct: 219 CIPEHISPKARC---------LIRSLLRREPSERLTAPEILLHPWF 255 >5L2Q-C nrPDB Length = 320 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/133 (28%), Positives = 71/133 (53%), Gaps = 12/133 (9%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDA-G 215 I +V+ +E LH K +++HRD+K N+++N ++ + +F + +LV D G Sbjct: 158 IFYDVVRVVEALHQK-NIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRG 216 Query: 216 CKPYMAPERINPELNQKGYSVK-SDIWSLGITMIELAILRFP-YDSWGTPFQQLKQVVEE 273 Y++P+ L+ + Y K SD+W+LG+ + + +FP YDS P Q+L + ++ Sbjct: 217 SPAYISPD----VLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDS--IP-QELFRKIKA 269 Query: 274 PSPQLPADKFSAE 286 +P D +E Sbjct: 270 AEYTIPEDGRVSE 282 >5CEK-A nrPDB Length = 263 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/106 (26%), Positives = 50/106 (47%), Gaps = 17/106 (16%) Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQ--- 269 GC Y++PE +N G + +D+WSLG+ + L + R+P+ F ++++ Sbjct: 164 GCPAYVSPEILNTTGTYSGKA--ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQF 221 Query: 270 -VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + E SP+ L++ ER T PE++ HP+F Sbjct: 222 CIPEHISPKARC---------LIRSLLRREPSERLTAPEILLHPWF 258 >2PZI-A nrPDB Length = 681 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 10/107 (9%) Query: 146 KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV 205 KGQ +P + I+ AL +LHS + +++ D+KP N+++ Q+K+ D G Sbjct: 175 KGQKLPVAEAIAYLLEILPALSYLHS-IGLVYNDLKPENIMLTE-EQLKLIDLG------ 226 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 I++ Y P PE+ + G +V +DI+++G T+ L + Sbjct: 227 --AVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTL 271 >5UV4-A nrPDB Length = 311 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 54/97 (55%), Gaps = 5/97 (5%) Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYL--VDSVAKTID 213 IA+ I + L++LH++ + H ++K SNVLI N+ + D+ + + + + ++ Sbjct: 132 NIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLN 191 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 AG Y PE ++ S+KSD+++ G+ ++EL Sbjct: 192 AGALGYSPPEF--SSTSKPCPSLKSDVYAFGVILLEL 226 >4Y12-A nrPDB Length = 375 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 10/107 (9%) Query: 146 KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV 205 KGQ +P + I+ AL +LHS + +++ D+KP N+++ Q+K+ D G Sbjct: 214 KGQKLPVAEAIAYLLEILPALSYLHS-IGLVYNDLKPENIMLTEE-QLKLIDLG------ 265 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 I++ Y P PE+ + G +V +DI+++G T+ L + Sbjct: 266 --AVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTL 310 >4WOV-A nrPDB Length = 317 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 76/166 (45%), Gaps = 28/166 (16%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-------VKMCDFGISGYLVDSVAK 210 +A + AL +L +K +++H +V N+L+ LG +K+ D G+ + ++++ Sbjct: 162 VAQQLASALSYLENK-NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVG---LGALSR 217 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL-----AILRFPYDSWGTPFQ 265 P++APE + N S D W G T++E+ A L+ S F Sbjct: 218 EERVERIPWLAPECLPGGANS--LSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFY 275 Query: 266 QLKQVVEEPS-PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 Q + + EPS PQL TSQCL +RP++ +++ Sbjct: 276 QRQHRLPEPSCPQL---------ATLTSQCLTYEPTQRPSFRTILR 312 >5C01-A nrPDB Length = 342 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 76/166 (45%), Gaps = 28/166 (16%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-------VKMCDFGISGYLVDSVAK 210 +A + AL +L +K +++H +V N+L+ LG +K+ D G+ + ++++ Sbjct: 185 VAQQLASALSYLENK-NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVG---LGALSR 240 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL-----AILRFPYDSWGTPFQ 265 P++APE + N S D W G T++E+ A L+ S F Sbjct: 241 EERVERIPWLAPECLPGGANS--LSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFY 298 Query: 266 QLKQVVEEPS-PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 Q + + EPS PQL TSQCL +RP++ +++ Sbjct: 299 QRQHRLPEPSCPQL---------ATLTSQCLTYEPTQRPSFRTILR 335 >5TQX-A nrPDB Length = 655 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 57/260 (21%), Positives = 107/260 (41%), Gaps = 36/260 (13%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS--------MRTVDCP 110 LG G +G V +H +A+K R ++++ ++R ++ I ++ D P Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVP 75 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG-------KIAVSIV 163 + L + + + M+ +++++K PE+ G + I Sbjct: 76 EELNI---LIHD----VPLLAMEYCSGGDLRKLLNK----PENCCGLKESQILSLLSDIG 124 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQV---KMCDFGISGYLVDSVAKTIDAGCKPYM 220 + +LH +IHRD+KP N+++ +G K+ D G + + T G Y+ Sbjct: 125 SGIRYLHEN-KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYL 183 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV-VEEPSPQLP 279 APE K Y+ D WS G + E P+ PF +++ ++P Sbjct: 184 APEL----FENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFA 239 Query: 280 ADKFSAEFVDFTSQCLKKNS 299 ++ S E V F+S + NS Sbjct: 240 CEEMSGE-VRFSSHLPQPNS 258 >1LUF-A nrPDB Length = 343 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 67/152 (44%), Gaps = 11/152 (7%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG--YLVDSV-AKTIDA 214 IA + + +L S+ +HRD+ N L+ VK+ DFG+S Y D A DA Sbjct: 179 IARQVAAGMAYL-SERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDA 237 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVEE 273 +M PE I Y+ +SD+W+ G+ + E+ PY +G +++ V + Sbjct: 238 IPIRWMPPESI----FYNRYTTESDVWAYGVVLWEIFSYGLQPY--YGMAHEEVIYYVRD 291 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 + + E + C K +RP++ Sbjct: 292 GNILACPENCPLELYNLMRLCWSKLPADRPSF 323 >3V5Q-A nrPDB Length = 297 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 96/231 (41%), Gaps = 40/231 (17%) Query: 47 EVKADDLEPIMELGRGAYGVV-----EKMRHVPSGQIMAVKRIR-----ATVNSQEQKRL 96 +K D+ ELG GA+G V + ++AVK ++ A + Q + L Sbjct: 11 HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAEL 70 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-LDKFYK------QVIDKGQT 149 L +L V FYG + + E M L+KF + ++ GQ Sbjct: 71 LTNLQHE-------HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQ- 122 Query: 150 IPEDILGKIAVS--------IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS 201 P G++ +S I + +L S+ +HRD+ N L+ A VK+ DFG+S Sbjct: 123 -PRQAKGELGLSQMLHIASQIASGMVYLASQ-HFVHRDLATRNCLVGANLLVKIGDFGMS 180 Query: 202 GYLVDSVAKTIDAGCKPYMAPERINP--ELNQKGYSVKSDIWSLGITMIEL 250 + + + M P R P + + ++ +SD+WS G+ + E+ Sbjct: 181 RDVYSTDYYRVGGHT---MLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 228 >5FQD-C nrPDB Length = 341 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/274 (22%), Positives = 125/274 (45%), Gaps = 33/274 (12%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK--RLLMD---LDISMRTVDCP 110 + ++G G++G + ++ +G+ +AVK + SQ+ + +LL + I V P Sbjct: 24 VRKIGSGSFGDIYLAINITNGEEVAVK-----LESQKARHPQLLYESKLYKILQGGVGIP 78 Query: 111 FTVTFYGALFREGDVWI-CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 + +YG +E D + M+L+ SL+ + + T+ ++ +A ++ +E++ Sbjct: 79 H-IRWYG---QEKDYNVLVMDLLGPSLEDLF-NFCSRRFTMKTVLM--LADQMISRIEYV 131 Query: 170 HSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVDSVAKTI-----DAGCKPYMA 221 H+K + IHRD+KP N L+ ++ + DFG++ D+ + D Sbjct: 132 HTK-NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTAR 190 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEE--PSP- 276 IN L + S + D+ SLG ++ P+ T Q+ +++ E+ +P Sbjct: 191 YASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPV 249 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 ++ F AEF + + C +E P Y L Q Sbjct: 250 EVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQ 283 >4JRN-A nrPDB Length = 372 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/75 (34%), Positives = 41/75 (54%), Gaps = 8/75 (10%) Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG- 233 ++H D+KP+N L+ G++ + DFG + + +SV + I G Y PER G Sbjct: 223 IVHTDIKPANFLLLKDGRLFLGDFG-TYRINNSVGRAI--GTPGYEPPER---PFQATGI 276 Query: 234 -YSVKSDIWSLGITM 247 Y+ +D W LGIT+ Sbjct: 277 TYTFPTDAWQLGITL 291 >3ZZW-A nrPDB Length = 289 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 11/104 (10%) Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--SGYLVDSV 208 P D + +A I +E+L S V+H+D+ NVL+ VK+ D G+ Y D Sbjct: 127 PPDFVHLVA-QIAAGMEYLSSH-HVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 184 Query: 209 AKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 K + P +MAPE I +S+ SDIWS G+ + E+ Sbjct: 185 -KLLGNSLLPIRWMAPEAI----MYGKFSIDSDIWSYGVVLWEV 223 >4AT3-A nrPDB Length = 299 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 104/235 (44%), Gaps = 33/235 (14%) Query: 58 ELGRGAYGVV---EKMRHVPSGQ--IMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPF 111 ELG GA+G V E P ++AVK ++ A+ N+++ +L + + Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAEL---LTNLQHEH 76 Query: 112 TVTFYGALFREGDVWICMELMDTS-LDKFYKQ------VIDKGQ---TIPEDILGKIAVS 161 V FYG + + E M L+KF + ++ +G + + + IA Sbjct: 77 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ 136 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 I + +L S+ +HRD+ N L+ VK+ DFG+S + + + M Sbjct: 137 IAAGMVYLASQ-HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHT---ML 192 Query: 222 PERINP--ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQL--KQVVE 272 P R P + + ++ +SD+WSLG+ + E+ F Y P+ QL +V+E Sbjct: 193 PIRWMPPESIMYRKFTTESDVWSLGVVLWEI----FTYGK--QPWYQLSNNEVIE 241 >5VC6-A nrPDB Length = 289 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 59/280 (21%), Positives = 118/280 (42%), Gaps = 31/280 (11%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-NSQEQKRLLMDLDISMRTVDCP 110 + + ++G G +G V K G I A+KR + + S +++ L ++ Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 111 FTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V ++ A + + I E + SL + E L + + + + L ++ Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 170 HSKLSVIHRDVKPSNVLI------NALGQVK----------MCDFGISGYLVDSVAKTID 213 HS +S++H D+KPSN+ I NA + M G G++ + ++ Sbjct: 132 HS-MSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVE 190 Query: 214 AGCKPYMAPERINPELNQKGYSV--KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G ++A E + Q+ Y+ K+DI++L +T++ A P G + +++Q Sbjct: 191 EGDSRFLANEVL-----QENYTHLPKADIFALALTVV-CAAGAEPLPRNGDQWHEIRQGR 244 Query: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 PQ+ S EF + + + + RP+ L++H Sbjct: 245 LPRIPQV----LSQEFTELLKVMIHPDPERRPSAMALVKH 280 >4XHH-A nrPDB Length = 403 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 64/278 (23%), Positives = 122/278 (43%), Gaps = 45/278 (16%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT-------VDCP 110 ++G G++G + ++ SG+ +A+ R+ + + Q LD R V P Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQ------LDYESRVYKYLSGGVGIP 66 Query: 111 FTVTFYGALFREGDV-WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 F + ++G REG+ + ++L+ SL+ + K + +A+ ++ ++++ Sbjct: 67 F-IRWFG---REGEYNAMVIDLLGPSLEDLFNYCHRK---FSFKTVIMLALQMICRVQYI 119 Query: 170 HSKLSVIHRDVKPSNVLINALGQ----VKMCDFGISGYLVD-SVAKTID-------AGCK 217 H + S IHRD+KP N L+ +G+ V + DFG+S D + + I G Sbjct: 120 HGR-SFIHRDIKPDNFLM-GVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEEP- 274 Y + +N L + S + D+ SLG +I P+ T Q+ +++E+ Sbjct: 178 RYAS---VNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKL 233 Query: 275 --SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 S + EF ++ + C ERP Y L + Sbjct: 234 CISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLAR 271 >5X18-A nrPDB Length = 295 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 49/220 (22%), Positives = 95/220 (43%), Gaps = 26/220 (11%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ++G G++GV+ + ++ +G +A+K + + + I T + P+ F Sbjct: 14 KIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYYF-- 71 Query: 118 ALFREG-DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 +EG + ++L+ SL+ + G+ + ++AV ++ +E LH+ +I Sbjct: 72 --GQEGLHNILVIDLLGPSLEDLFDWC---GRKFSVKTVVQVAVQMITLIEDLHAH-DLI 125 Query: 177 HRDVKPSNVLINALGQ-----VKMCDFGISGYLVDSVAKTID--------AGCKPYMAPE 223 +RD+KP N LI GQ + + DFG++ D K +G YM+ Sbjct: 126 YRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMS-- 183 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 IN L ++ S + D+ +LG P+ P Sbjct: 184 -INTHLGRE-QSRRDDMEALGHVFFYFLRGHLPWQGLKAP 221 >6BFN-A nrPDB Length = 342 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 108/256 (42%), Gaps = 45/256 (17%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN---SQEQKR 95 IS G NF + +++G G +G V R V + AVKR++ + + ++ Sbjct: 17 ISRGTHNFSEE-------LKIGEGGFGCV--YRAVMRNTVYAVKRLKENADLEWTAVKQS 67 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSL-DKFYKQVIDKGQTIPE- 152 L +++ + P V F G + G + + + SL D+ + Q Q P Sbjct: 68 FLTEVE-QLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQT----QACPPL 122 Query: 153 ------DILGKIAVSIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISGY-- 203 DIL + +A++ LH S+IH D+K SNVL++ K+ DFG++ + Sbjct: 123 SWPQRLDIL----LGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSR 178 Query: 204 -------LVDSVAKTIDA-GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 VA+T G Y+ E I +V +D +S G+ ++E + Sbjct: 179 FAGSSPSQSSMVARTQTVRGTLAYLPEEYI----KTGRLAVDTDTFSFGVVVLETLAGQR 234 Query: 256 PYDSWGTPFQQLKQVV 271 + G + LK +V Sbjct: 235 AVKTHGARTKYLKDLV 250 >4L68-A nrPDB Length = 340 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/165 (22%), Positives = 70/165 (42%), Gaps = 23/165 (13%) Query: 157 KIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYLV-----DSVA 209 +I + + L LH ++H+++ S +LI+ ++ D G++ +V +S Sbjct: 140 RIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSF 199 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI---------LRFPYDSW 260 T D G Y+APE L S+K D++ LG+ ++ELA + W Sbjct: 200 MTGDLGEFGYVAPEYSTTMLA----SLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDW 255 Query: 261 GTPFQQLKQVVEEPSPQLPA---DKFSAEFVDFTSQCLKKNSKER 302 + ++ E + D+ ++FV+ C+ KER Sbjct: 256 VKQLESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKER 300 >2CHL-A nrPDB Length = 351 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 9/89 (10%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + +EL+ SL+ + + D+ ++ ++ IA+ ++ +E++HSK ++I+RDVKP N L Sbjct: 103 MVLELLGPSLEDLF-DLCDRTFSLKTVLM--IAIQLISRMEYVHSK-NLIYRDVKPENFL 158 Query: 187 INALGQ-----VKMCDFGISGYLVDSVAK 210 I G + + DF ++ +D K Sbjct: 159 IGRPGNKTQQVIHIIDFALAKEYIDPETK 187 >3SV0-A nrPDB Length = 483 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 89/205 (43%), Gaps = 27/205 (13%) Query: 122 EGDVWI-CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 EGD + M+L+ SL+ + K + + +A ++ +E +HSK S +HRD+ Sbjct: 74 EGDYNVLVMDLLGPSLEDLFNFCSRK---LSLKTVLMLADQMINRVEFVHSK-SFLHRDI 129 Query: 181 KPSNVLINALG----QVKMCDFGIS-GYLVDSVAKTID-------AGCKPYMAPERINPE 228 KP N L+ LG QV + DFG++ Y S + I G Y + +N Sbjct: 130 KPDNFLM-GLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYAS---VNTH 185 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEE---PSPQLPADKF 283 L + S + D+ SLG ++ P+ GT Q+ +++ E+ S + + Sbjct: 186 LGIE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCRGY 244 Query: 284 SAEFVDFTSQCLKKNSKERPTYPEL 308 EF + C ++P Y L Sbjct: 245 PTEFASYFHYCRSLRFDDKPDYSYL 269 >4WUA-A nrPDB Length = 401 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 4/64 (6%) Query: 127 ICM--ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 ICM E++ L K+ + Q +P + KI +++ L++LH+K +IH D+KP N Sbjct: 124 ICMVFEVLGHHLLKWI--IKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPEN 181 Query: 185 VLIN 188 +L++ Sbjct: 182 ILLS 185 >4NT4-A nrPDB Length = 312 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 44/190 (23%), Positives = 81/190 (42%), Gaps = 27/190 (14%) Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVD------ 206 IA ++ +E++HS+ +I+RDVKP N LI + + DFG++ +D Sbjct: 119 IAKQLLHRIEYVHSR-HLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRH 177 Query: 207 ---SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----D 258 K++ G YM+ IN + ++ S + D+ +LG + P+ D Sbjct: 178 IPYREHKSL-TGTARYMS---INTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKAD 232 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 + +Q++ ++ D EF + + + E P Y + ++ F L + Sbjct: 233 TLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY-DFLRRLFQDLFD 291 Query: 319 SKG-TDVASF 327 KG TD F Sbjct: 292 RKGYTDEGEF 301 >5VDK-A nrPDB Length = 297 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 56/277 (20%), Positives = 109/277 (39%), Gaps = 31/277 (11%) Query: 56 IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-QEQKRLLMDLDISMRTVDCPFTVT 114 + ++G G +G V K G + A+KR T + L ++ P V Sbjct: 20 VEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVR 79 Query: 115 FYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 +Y + + + I E + SL + G E L I + I L ++H+ Sbjct: 80 YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNS- 138 Query: 174 SVIHRDVKPSNVLI---------NALGQVK-----------MCDFGISGYLVDSVAKTID 213 S++H D+KPSN+ I + +V+ M G G+ ++ Sbjct: 139 SMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVE 198 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G ++A E + + + K+DI++LG+T I +A + G + +++ Sbjct: 199 EGDSRFLANEILQEDYR---HLPKADIFALGLT-IAVAAGAESLPTNGAAWHHIRKGNFP 254 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 PQ + S F ++ ++++RP+ L + Sbjct: 255 DVPQ----ELSESFSSLLKNMIQPDAEQRPSAAALAR 287 >4O1O-A nrPDB Length = 717 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 59/248 (23%), Positives = 95/248 (38%), Gaps = 47/248 (18%) Query: 77 QIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS 135 Q +AVKR + Q++ L S R D VTFYG+ + +C+ L + + Sbjct: 370 QEVAVKRFSEGSTRGQQEVSCLQ----SSRANDN--VVTFYGSESDGSCLHVCLALCEYT 423 Query: 136 LDKFYKQVIDKGQTIP--EDILGK-IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ 192 L + +G +P ED + I S+ KA+ LH + H+D++P N+LI++ Sbjct: 424 LQEHLAN--HRGDAVPNEEDESARNILSSLFKAIGELH-RSGYSHQDLQPQNILIDSKNG 480 Query: 193 VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 + DF D K P++I K D+ +LG+ ++ Sbjct: 481 TFLADF--------------DKSIKWAEDPQKI-----------KRDLEALGLLVL---- 511 Query: 253 LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHP 312 + F+ LK E Q D+ E D L+ HP Sbjct: 512 --YVVKKGDISFETLKNQSFEEVIQGSPDE---ETRDLIHHLFHPGDNVEDRLSSLLAHP 566 Query: 313 FFTLHESK 320 FF ES+ Sbjct: 567 FFWSWESR 574 >4I94-A nrPDB Length = 300 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 35/159 (22%), Positives = 67/159 (42%), Gaps = 26/159 (16%) Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216 ++A+ I +ALE+ SK ++ D+ VL + ++ FG+ D + + + Sbjct: 131 RVALHIAQALEYCTSKGRALYHDLNAYRVLFDDDANPRLSCFGLMKNSRDGKSYSTNLAF 190 Query: 217 KP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 P Y+ R+ PE S I+S G +++L P ++ + Sbjct: 191 TPPEYLRTGRVTPE---------SVIYSFGTLLLDL------LSGKHIPPSHALDLIRDR 235 Query: 275 SPQLPAD-----KFSA----EFVDFTSQCLKKNSKERPT 304 + Q+ D +FS+ E + S+CL+ +ERP Sbjct: 236 NIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPN 274 >2X7G-A nrPDB Length = 389 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 26/40 (65%) Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187 Q +P + I +++ L++LHSK +IH D+KP N+L+ Sbjct: 135 QGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 174 >4XHL-A nrPDB Length = 394 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 61/273 (22%), Positives = 119/273 (43%), Gaps = 45/273 (16%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT-------VDCP 110 ++G G++G + ++ SG+ +A+ R+ + + Q LD R V P Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQ------LDYESRVYRYLSGGVGIP 66 Query: 111 FTVTFYGALFREGDV-WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 F + ++G REG+ + ++L+ SL+ + + + +A+ + ++++ Sbjct: 67 F-IRWFG---REGEYNAMVIDLLGPSLEDLFNYC---HRRFSFKTVIMLALQMFCRIQYI 119 Query: 170 HSKLSVIHRDVKPSNVLINALGQ----VKMCDFGISGYLVD-SVAKTID-------AGCK 217 H + S IHRD+KP N L+ +G+ V + DFG+S D + + I G Sbjct: 120 HGR-SFIHRDIKPDNFLM-GVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEEP- 274 Y + +N L + S + D+ SLG +I P+ T Q+ +++E+ Sbjct: 178 RYAS---VNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKL 233 Query: 275 --SPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 S + EF ++ + C E+P Y Sbjct: 234 NVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDY 266 >6M7Z-A nrPDB Length = 319 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 42/184 (22%), Positives = 78/184 (42%), Gaps = 35/184 (19%) Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS- 201 +++ G++ P+ + +A ++V AL+ LH+ L ++HR ++ ++ + G V + + Sbjct: 136 MLETGRSHPD--VQVLAANMVAALKSLHN-LGLLHRSIELNSFSVLPDGTVVLGGLDTAA 192 Query: 202 ----------GYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA 251 G+ A ID +A L Q ++VKSD++SLG+ L Sbjct: 193 PIGTETRLWVGFFGQETAPEIDRNFLADLA-------LTQGRHTVKSDVYSLGVAFRNLV 245 Query: 252 ILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQ-CLKKNSKERPTYPELMQ 310 Q L P + + E +D SQ +++ RPT E+M+ Sbjct: 246 -------------QLLGNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMK 292 Query: 311 HPFF 314 P F Sbjct: 293 DPLF 296 >6EQI-C nrPDB Length = 433 Score = 36.2 bits (82), Expect = 0.023, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 74/158 (46%), Gaps = 27/158 (17%) Query: 164 KALEHLHSKLSVIHRDVKPSNVLI-----NALGQVKMCDFGI------SGYLVDSVAKTI 212 +A+ H++ ++ HRD+K N+L+ +A + + DFG +G ++ ++ Sbjct: 178 EAVAHMNIH-NISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQ 236 Query: 213 D-AGCKPYMAPERINPE------LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 D G + MAPE N + LN K KSD+W++G E+ + P+ + + Sbjct: 237 DKGGNRALMAPEIANAKPGTFSWLNYK----KSDLWAVGAIAYEIFNIDNPF--YDKTMK 290 Query: 266 QL-KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKER 302 L K EE P+LP D + S L +++ +R Sbjct: 291 LLSKSYKEEDLPELP-DTIPFIIRNLVSNMLSRSTNKR 327 >6J6I-B nrPDB Length = 351 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 13/106 (12%) Query: 150 IPEDILGKIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYLVDS 207 +P + KI I A+ +LH+ +IHRDVKP +V ++ K+ D S L + Sbjct: 160 LPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEG 219 Query: 208 VAKTIDA----GCKPYMAPERINPELNQKGYSVK-SDIWSLGITMI 248 ++ I+A G Y I+P ++ + + +D++S GI ++ Sbjct: 220 KSR-IEAEWVLGTFGY-----IDPLYHKTCFVTEYTDVYSFGICLL 259 >4AZV-A nrPDB Length = 569 Score = 35.4 bits (80), Expect = 0.037, Method: Compositional matrix adjust. Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 9/75 (12%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIP-EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 W+ ME + L ++ G+ I E ILG + S+ ALE K H DV+P N Sbjct: 318 WLVMEKLPGRL---LSDMLAAGEEIDREKILGSLLRSLA-ALE----KQGFWHDDVRPWN 369 Query: 185 VLINALGQVKMCDFG 199 V+++A ++ DFG Sbjct: 370 VMVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 35.0 bits (79), Expect = 0.043, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 W+ ME + L ++ G+ I + KI S++++L L K H DV+P NV Sbjct: 318 WLVMEKLPGRL---LSDMLAAGEEIDRE---KILGSLLRSLAALEKK-GFWHDDVRPWNV 370 Query: 186 LINALGQVKMCDFG 199 +++A ++ DFG Sbjct: 371 MVDARQHARLIDFG 384 >5DJ3-A nrPDB Length = 376 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 15/57 (26%), Positives = 26/57 (45%) Query: 74 PSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICME 130 P+G+++A +R+R + ++ LD S R D Y L G W+ +E Sbjct: 161 PTGRVLAEERLRRLAEQCAEHGTVLALDTSFRGFDAAAHYDHYAVLQEAGCRWVVIE 217 >2LAV-A nrPDB Length = 361 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 ++ M+ + L K Y+ + + ++++ I+ LE++H +H D+K SN+ Sbjct: 128 FMIMDRFGSDLQKIYEA---NAKRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNL 183 Query: 186 LINALG--QVKMCDFGIS 201 L+N QV + D+G++ Sbjct: 184 LLNYKNPDQVYLVDYGLA 201 >2RSV-A nrPDB Length = 403 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 41/78 (52%), Gaps = 6/78 (7%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 ++ M+ + L K Y+ + + ++++ I+ LE++H +H D+K SN+ Sbjct: 135 FMIMDRFGSDLQKIYEA---NAKRFSRKTVLQLSLRILDILEYIHEH-EYVHGDIKASNL 190 Query: 186 LINALG--QVKMCDFGIS 201 L+N QV + D+G++ Sbjct: 191 LLNYKNPDQVYLVDYGLA 208 >3C1D-A nrPDB Length = 159 Score = 31.2 bits (69), Expect = 0.67, Method: Compositional matrix adjust. Identities = 18/39 (46%), Positives = 23/39 (58%), Gaps = 2/39 (5%) Query: 202 GYLVDS--VAKTIDAGCKPYMAPERINPELNQKGYSVKS 238 GYL DS VA+ I + + P RI ELNQKG S ++ Sbjct: 60 GYLDDSRFVARFIASRSRKGYGPARIRQELNQKGISREA 98 >1CSN-A nrPDB Length = 298 Score = 31.2 bits (69), Expect = 0.69, Method: Compositional matrix adjust. Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 20/112 (17%) Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI------NALGQVKMCDFGI 200 G+ + A ++ ++ +H K S+++RD+KP N LI NA + + DFG+ Sbjct: 100 GRKFSVKTVAMAAKQMLARVQSIHEK-SLVYRDIKPDNFLIGRPNSKNA-NMIYVVDFGM 157 Query: 201 SGYLVDSVAKTID--------AGCKPYMAPERINPELNQKGYSVKSDIWSLG 244 + D V K +G YM+ IN L ++ S + D+ +LG Sbjct: 158 VKFYRDPVTKQHIPYREKKNLSGTARYMS---INTHLGREQ-SRRDDLEALG 205 >1ZD8-A nrPDB Length = 227 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 29/61 (47%) Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 TV T F GD+ L T + K ID+G+ IP+D++ ++A+ +K Sbjct: 22 TVSSRITTHFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDVMTRLALHELKN 81 Query: 166 L 166 L Sbjct: 82 L 82 >4IX6-A nrPDB Length = 350 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 24/120 (20%) Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTI-----DA 214 ++ +L LH + V+HRDVKP+N++ G +K+ D G + L + +T+ D Sbjct: 152 LLGSLARLH-ECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAA-LCLPLPETLNYYPGDG 209 Query: 215 GCKPYMA--------------PERIN-PELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 P A P + N +L + + D WS G M++LA++ D+ Sbjct: 210 PADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVGLRTDA 269 >1L1L-A nrPDB Length = 739 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 39/96 (40%), Gaps = 13/96 (13%) Query: 161 SIVKALEHLHSKL----SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216 ++VKA + L S+ H VKPS + G + F YL+ + Sbjct: 524 AVVKADQDYSKTLGCNESIKHTTVKPSGTVAKLAGASEGMHFHYGAYLIQRIR------- 576 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 + + + P L GY ++DI++ T +E I Sbjct: 577 --FQDSDPLLPALKACGYRTEADIYTENTTCVEFPI 610 >5X1R-A nrPDB Length = 302 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 32/156 (20%), Positives = 63/156 (40%), Gaps = 5/156 (3%) Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS 207 + I E + ++ + A+ +H + +HRD+ N+ I + DFG + + + Sbjct: 135 EKIDEAWIRRLLPPLFSAINTIHQE-GYLHRDISLDNIQIQESQLPVLLDFGSARKEIGN 193 Query: 208 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQL 267 ++ + KP AP E + +DI++LG + L + P S + Sbjct: 194 LSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVSVVRSIEDS 253 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 Q + E P +S E + + L ++RP Sbjct: 254 YQPLTERRPA----GYSPELLRTVDRALALKPEDRP 285 >5DMZ-A nrPDB Length = 365 Score = 29.3 bits (64), Expect = 2.6, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 7/79 (8%) Query: 113 VTFYGA-LFREGDVWIC-MELMDTSLD--KFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + FY A LF+ G V + + T L+ YK +K +P+ ++ A+ ++ +E Sbjct: 130 MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEK--VMPQGLVISFAMRMLYMIEQ 187 Query: 169 LHSKLSVIHRDVKPSNVLI 187 +H +IH D+KP N ++ Sbjct: 188 VHD-CEIIHGDIKPDNFIL 205 >4J4X-A nrPDB Length = 257 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 20/45 (44%), Gaps = 12/45 (26%) Query: 282 KFSAEFVDFTSQCLKKNSKERP------------TYPELMQHPFF 314 + SA FV +T Q LK S+ P TYP M HP F Sbjct: 114 RVSAAFVPWTVQALKTLSESLPVTGTTMDSIAGTTYPRCMMHPSF 158 >2WCI-A nrPDB Length = 135 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 12/70 (17%) Query: 268 KQVVEEP-------SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 +Q+ E P SP+LP+ FSA+ V + C ER Y +++Q+P K Sbjct: 30 RQIAENPILLYMKGSPKLPSCGFSAQAVQALAAC-----GERFAYVDILQNPDIRAELPK 84 Query: 321 GTDVASFVKL 330 + +F +L Sbjct: 85 YANWPTFPQL 94 >4EAC-A nrPDB Length = 414 Score = 28.5 bits (62), Expect = 3.9, Method: Compositional matrix adjust. Identities = 10/23 (43%), Positives = 17/23 (73%) Query: 62 GAYGVVEKMRHVPSGQIMAVKRI 84 GA GVV + H+P+G++ +V+ I Sbjct: 43 GATGVVTALHHIPNGEVWSVEEI 65 >1YKA-A nrPDB Length = 115 Score = 28.5 bits (62), Expect = 4.5, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 12/70 (17%) Query: 268 KQVVEEP-------SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 +Q+ E P SP+LP+ FSA+ V + C ER Y +++Q+P K Sbjct: 10 RQIAENPILLYMKGSPKLPSCGFSAQAVQALAAC-----GERFAYVDILQNPDIRAELPK 64 Query: 321 GTDVASFVKL 330 + +F +L Sbjct: 65 YANWPTFPQL 74 >2AK3-A nrPDB Length = 226 Score = 28.5 bits (62), Expect = 4.6, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 35/84 (41%) Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 TV T F GD+ L T + K ID+G+ IP+D++ ++ + +K Sbjct: 21 TVSSRITKHFELKHLSSGDLLRDNMLRGTEIGVLAKTFIDQGKLIPDDVMTRLVLHELKN 80 Query: 166 LEHLHSKLSVIHRDVKPSNVLINA 189 L + L R + + L A Sbjct: 81 LTQYNWLLDGFPRTLPQAEALDRA 104 >3BI4-A nrPDB Length = 516 Score = 27.7 bits (60), Expect = 7.6, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 25/48 (52%) Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 +AE +D L++ ++ T P F ++ SK T VASF+ L+ Sbjct: 329 NAENLDELDSMLEREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLM 376 >4FWE-A nrPDB Length = 796 Score = 27.7 bits (60), Expect = 7.9, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 22/42 (52%), Gaps = 3/42 (7%) Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 + NP L++K I SLG +IE L+FPY W + Q Sbjct: 612 QFNPPLSEKKMKA---INSLGAGIIEKIALQFPYRFWDSKVQ 650 >5YK0-A nrPDB Length = 452 Score = 27.3 bits (59), Expect = 8.4, Method: Compositional matrix adjust. Identities = 14/58 (24%), Positives = 28/58 (48%), Gaps = 3/58 (5%) Query: 142 QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 ++I G T D++G + + +L ++H D P N ++ G++ + DFG Sbjct: 257 EIIRHGTTEQRDLIGTLLAELTFDAPR---RLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3VN9-A nrPDB 473 e-134 3FME-A nrPDB 405 e-113 3ALO-A nrPDB 335 1e-92 5B2L-A nrPDB 297 4e-81 3COM-A nrPDB 288 2e-78 4AN9-A nrPDB 275 2e-74 3DXN-A nrPDB 269 1e-72 4LG4-A nrPDB 269 1e-72 3HZT-A nrPDB 268 2e-72 4MVF-A nrPDB 267 7e-72 6AO5-A nrPDB 266 7e-72 3LIJ-A nrPDB 266 8e-72 4CSV-A nrPDB 265 2e-71 2VZ6-A nrPDB 264 4e-71 5KCV-A nrPDB 264 5e-71 5IG1-A nrPDB 263 7e-71 4QMW-A nrPDB 263 8e-71 3NCG-A nrPDB 263 9e-71 3MN3-A nrPDB 263 9e-71 2V7O-A nrPDB 263 9e-71 2FO0-A nrPDB 262 1e-70 2XIK-A nrPDB 262 1e-70 5KKR-C nrPDB 262 1e-70 2BDW-A nrPDB 262 1e-70 2VN9-A nrPDB 262 2e-70 5D7A-A nrPDB 262 2e-70 4XEY-B nrPDB 262 2e-70 2UV2-A nrPDB 262 2e-70 3DFA-A nrPDB 261 3e-70 3H4J-B nrPDB 261 4e-70 5FG8-A nrPDB 260 4e-70 3KK8-A nrPDB 260 6e-70 3EQC-A nrPDB 260 7e-70 2WQN-A nrPDB 259 1e-69 5JN2-A nrPDB 259 1e-69 2BPM-A nrPDB 258 3e-69 3MV5-A nrPDB 258 3e-69 3IS5-A nrPDB 257 5e-69 5U6Y-A nrPDB 256 7e-69 6HXF-B nrPDB 256 8e-69 2JC6-A nrPDB 256 8e-69 3DAK-A nrPDB 256 9e-69 4FZF-B nrPDB 255 2e-68 4CFF-A nrPDB 254 3e-68 5ES1-A nrPDB 254 4e-68 4FIE-A nrPDB 254 5e-68 5KZ7-A nrPDB 254 5e-68 4EBW-A nrPDB 254 5e-68 5EZV-A nrPDB 254 6e-68 3BHH-A nrPDB 254 6e-68 6FD3-A nrPDB 253 8e-68 4REW-A nrPDB 253 1e-67 5WAX-A nrPDB 252 1e-67 4UZD-A nrPDB 252 1e-67 4FG9-A nrPDB 252 1e-67 5J5T-A nrPDB 252 1e-67 4JDH-A nrPDB 252 1e-67 2QNJ-A nrPDB 252 2e-67 3MA6-A nrPDB 252 2e-67 3SOA-A nrPDB 251 4e-67 5D9K-A nrPDB 250 5e-67 1S9I-A nrPDB 250 5e-67 3TT0-A nrPDB 250 6e-67 5YKS-A nrPDB 250 6e-67 2JDO-A nrPDB 250 8e-67 6NPU-A nrPDB 250 8e-67 3UC3-A nrPDB 249 1e-66 4CFH-A nrPDB 249 1e-66 5A46-A nrPDB 249 1e-66 4YZB-A nrPDB 249 1e-66 2YZA-A nrPDB 249 2e-66 3GQL-A nrPDB 249 2e-66 3HDN-A nrPDB 248 2e-66 1PHK-A nrPDB 248 3e-66 4RED-A nrPDB 248 3e-66 4XCU-A nrPDB 248 3e-66 3D2K-A nrPDB 248 3e-66 5XZW-A nrPDB 248 3e-66 6GQK-A nrPDB 247 4e-66 2XYN-A nrPDB 247 5e-66 4U41-A nrPDB 247 7e-66 4XBR-A nrPDB 246 8e-66 5DBX-A nrPDB 246 9e-66 2Q0N-A nrPDB 246 1e-65 2JAM-A nrPDB 246 1e-65 2F57-A nrPDB 245 1e-65 3ZUT-A nrPDB 245 3e-65 2J0K-A nrPDB 245 3e-65 2W4O-A nrPDB 245 3e-65 3Q5I-A nrPDB 244 3e-65 2YCR-A nrPDB 244 3e-65 4P5Q-A nrPDB 244 5e-65 4KS7-A nrPDB 244 5e-65 2Z7Q-A nrPDB 244 5e-65 4CZT-A nrPDB 244 5e-65 4D28-A nrPDB 243 6e-65 2Y7J-A nrPDB 243 8e-65 1AD5-A nrPDB 243 8e-65 4BBM-A nrPDB 243 9e-65 3Q53-A nrPDB 243 9e-65 3NIZ-A nrPDB 243 1e-64 2OGV-A nrPDB 243 1e-64 4NIF-A nrPDB 242 1e-64 3UDB-A nrPDB 242 2e-64 3I6U-A nrPDB 242 2e-64 4E93-A nrPDB 241 2e-64 2PSQ-A nrPDB 241 3e-64 5MJB-A nrPDB 241 3e-64 3BEA-A nrPDB 241 4e-64 6E9W-A nrPDB 240 5e-64 4APC-A nrPDB 240 5e-64 5JZN-A nrPDB 240 7e-64 4RGJ-A nrPDB 240 9e-64 6GU6-A nrPDB 239 1e-63 2H8H-A nrPDB 239 1e-63 3KRL-A nrPDB 239 1e-63 1FOT-A nrPDB 239 1e-63 4I6B-A nrPDB 239 1e-63 4K33-A nrPDB 239 1e-63 6F3F-A nrPDB 239 2e-63 3F3Z-A nrPDB 239 2e-63 5EG3-A nrPDB 238 2e-63 4R7H-A nrPDB 238 2e-63 4JXF-A nrPDB 238 3e-63 6FDY-U nrPDB 238 3e-63 4PDS-A nrPDB 238 3e-63 5AMN-A nrPDB 238 3e-63 3CJF-A nrPDB 237 4e-63 4CQG-A nrPDB 237 4e-63 4JG6-A nrPDB 237 5e-63 1U5R-A nrPDB 237 5e-63 5F9E-A nrPDB 237 5e-63 5VO2-A nrPDB 237 6e-63 3DKO-A nrPDB 237 6e-63 3G0E-A nrPDB 237 7e-63 2YAB-A nrPDB 237 7e-63 2PL0-A nrPDB 236 8e-63 4AU8-A nrPDB 236 8e-63 2Y6O-A nrPDB 236 9e-63 5L6P-A nrPDB 236 9e-63 4L42-A nrPDB 236 1e-62 2GCD-A nrPDB 236 1e-62 3PPZ-A nrPDB 235 1e-62 4B6L-A nrPDB 235 2e-62 4RLP-A nrPDB 235 2e-62 6ED6-A nrPDB 235 2e-62 2HAK-A nrPDB 235 2e-62 3A8W-A nrPDB 235 2e-62 2F9G-A nrPDB 235 2e-62 3OHT-A nrPDB 235 2e-62 3TXO-A nrPDB 235 3e-62 1VZO-A nrPDB 235 3e-62 1CM8-A nrPDB 234 3e-62 3TAC-A nrPDB 234 3e-62 3KUL-B nrPDB 234 3e-62 4D2V-A nrPDB 234 3e-62 4RA4-A nrPDB 234 3e-62 4GS6-A nrPDB 234 3e-62 4AGU-A nrPDB 234 4e-62 1FVR-A nrPDB 234 4e-62 4FR4-A nrPDB 234 4e-62 6C9D-A nrPDB 234 4e-62 5SYS-A nrPDB 234 5e-62 2R2P-A nrPDB 234 5e-62 6DTL-A nrPDB 234 5e-62 6CQF-A nrPDB 234 6e-62 5AWM-A nrPDB 233 7e-62 5N23-A nrPDB 233 8e-62 1JPA-A nrPDB 233 9e-62 3GUB-A nrPDB 233 1e-61 4KRC-A nrPDB 232 1e-61 5FM2-A nrPDB 232 1e-61 2DQ7-X nrPDB 232 1e-61 4XLV-A nrPDB 232 1e-61 2A27-A nrPDB 232 2e-61 3PFQ-A nrPDB 232 2e-61 2VWV-A nrPDB 231 3e-61 5DYK-A nrPDB 231 3e-61 3A4O-X nrPDB 231 3e-61 4H1J-A nrPDB 231 3e-61 4EWQ-A nrPDB 231 3e-61 5X3F-B nrPDB 231 4e-61 2XNP-A nrPDB 230 4e-61 1ZWS-A nrPDB 230 5e-61 6E4F-A nrPDB 230 7e-61 6CMJ-A nrPDB 230 7e-61 3UTO-A nrPDB 230 7e-61 1JNK-A nrPDB 230 9e-61 4XUF-A nrPDB 229 1e-60 2X4F-A nrPDB 229 1e-60 2OU7-A nrPDB 229 1e-60 5X5O-A nrPDB 229 1e-60 2HK5-A nrPDB 229 1e-60 5X02-A nrPDB 229 1e-60 6E2O-A nrPDB 229 1e-60 3DTC-A nrPDB 229 2e-60 2I0E-A nrPDB 229 2e-60 3FI2-A nrPDB 229 2e-60 4WB7-A nrPDB 229 2e-60 4UY9-A nrPDB 229 2e-60 3DB8-A nrPDB 229 2e-60 4XI2-A nrPDB 229 2e-60 5GRN-A nrPDB 229 2e-60 3TKU-A nrPDB 228 2e-60 3OZ6-A nrPDB 228 3e-60 4J52-A nrPDB 228 3e-60 4IC8-A nrPDB 228 3e-60 1KOA-A nrPDB 228 3e-60 5Z33-A nrPDB 227 4e-60 2BRG-A nrPDB 227 4e-60 3HMP-A nrPDB 227 5e-60 2ZMD-A nrPDB 227 5e-60 5FET-A nrPDB 227 6e-60 2XS0-A nrPDB 227 6e-60 4UYA-A nrPDB 227 8e-60 3ZDU-A nrPDB 226 9e-60 1UA2-A nrPDB 226 1e-59 1G3N-A nrPDB 226 1e-59 1NY3-A nrPDB 225 1e-59 3SXS-A nrPDB 225 1e-59 3E7O-A nrPDB 225 2e-59 4YNZ-A nrPDB 225 2e-59 3KA0-A nrPDB 225 2e-59 2OZA-A nrPDB 225 3e-59 3NYO-A nrPDB 224 4e-59 4QTB-A nrPDB 224 4e-59 4C0T-A nrPDB 224 5e-59 4MYG-A nrPDB 224 5e-59 4Y93-A nrPDB 223 5e-59 3GC9-A nrPDB 223 6e-59 4PDO-A nrPDB 223 6e-59 3V5Q-A nrPDB 223 6e-59 4ZSG-A nrPDB 223 7e-59 6GVJ-A nrPDB 223 7e-59 3LM0-A nrPDB 223 9e-59 3BBT-B nrPDB 223 1e-58 5H2U-A nrPDB 223 1e-58 4AW2-A nrPDB 222 1e-58 5O2C-A nrPDB 222 1e-58 1V0B-A nrPDB 222 1e-58 5NGU-A nrPDB 222 2e-58 5O2B-A nrPDB 222 2e-58 4WNO-A nrPDB 222 2e-58 5LOH-A nrPDB 222 2e-58 4AF3-A nrPDB 221 3e-58 1KOB-A nrPDB 221 3e-58 3C51-A nrPDB 220 5e-58 3KN6-A nrPDB 220 5e-58 5EFQ-A nrPDB 220 6e-58 4OLI-A nrPDB 220 7e-58 3QGY-A nrPDB 220 7e-58 6BSD-A nrPDB 220 7e-58 6FEX-A nrPDB 220 9e-58 1K9A-A nrPDB 220 9e-58 5YV8-A nrPDB 220 1e-57 4B8L-A nrPDB 220 1e-57 4TNB-A nrPDB 219 1e-57 3ORZ-A nrPDB 219 1e-57 3LZB-A nrPDB 218 2e-57 1LUF-A nrPDB 218 2e-57 5GNK-A nrPDB 218 2e-57 4BGQ-A nrPDB 218 2e-57 4NST-A nrPDB 218 2e-57 3PP0-A nrPDB 218 3e-57 3I81-A nrPDB 218 3e-57 6DBM-A nrPDB 218 4e-57 5UUU-A nrPDB 217 4e-57 4PWN-A nrPDB 217 6e-57 2HW6-A nrPDB 217 6e-57 1BYG-A nrPDB 217 6e-57 2OZO-A nrPDB 217 8e-57 4AT3-A nrPDB 216 8e-57 3PVW-A nrPDB 216 8e-57 2VD5-A nrPDB 216 1e-56 4O2Z-A nrPDB 216 1e-56 3FXW-A nrPDB 216 1e-56 3HKO-A nrPDB 215 2e-56 5G6V-A nrPDB 215 3e-56 4QNY-A nrPDB 214 4e-56 6QAU-A nrPDB 214 5e-56 3AOX-A nrPDB 213 5e-56 6BDL-A nrPDB 213 8e-56 5U6B-A nrPDB 213 9e-56 1U59-A nrPDB 213 9e-56 4LRM-A nrPDB 213 1e-55 3OMV-A nrPDB 213 1e-55 4E7W-A nrPDB 212 1e-55 5KMM-A nrPDB 212 1e-55 5AIR-A nrPDB 212 2e-55 4E20-A nrPDB 212 2e-55 5HI2-A nrPDB 212 3e-55 2W96-B nrPDB 211 4e-55 5O0Y-A nrPDB 211 4e-55 4NEU-A nrPDB 211 4e-55 3ZBF-A nrPDB 211 4e-55 5HIE-A nrPDB 210 9e-55 5AP3-A nrPDB 209 1e-54 2W1I-A nrPDB 209 2e-54 3IO7-A nrPDB 209 2e-54 6FER-A nrPDB 208 3e-54 4HZS-A nrPDB 207 5e-54 4YHJ-A nrPDB 207 7e-54 3MIA-A nrPDB 206 9e-54 3GC0-A nrPDB 206 1e-53 6DBN-A nrPDB 206 1e-53 3E3P-A nrPDB 206 1e-53 3QUP-A nrPDB 205 2e-53 6CCF-A nrPDB 205 2e-53 1U54-B nrPDB 205 2e-53 5VD3-A nrPDB 205 3e-53 6CKI-A nrPDB 204 4e-53 4F0G-A nrPDB 204 5e-53 5HLW-A nrPDB 203 7e-53 4CRS-A nrPDB 203 1e-52 4OTD-A nrPDB 202 1e-52 5U6C-A nrPDB 202 2e-52 3PLS-A nrPDB 202 3e-52 3RP9-A nrPDB 201 3e-52 3C1X-A nrPDB 201 3e-52 5TOS-A nrPDB 201 4e-52 5TUR-A nrPDB 200 5e-52 6BXI-A nrPDB 200 7e-52 4HVI-A nrPDB 200 1e-51 3BGP-A nrPDB 199 1e-51 3N9X-A nrPDB 199 2e-51 5HVK-A nrPDB 199 2e-51 4C59-A nrPDB 198 2e-51 4M7I-A nrPDB 198 2e-51 3EB0-A nrPDB 198 3e-51 1ZXE-A nrPDB 198 3e-51 3DLS-A nrPDB 197 4e-51 5WNL-A nrPDB 197 5e-51 4RC3-A nrPDB 197 7e-51 4YFF-A nrPDB 196 1e-50 3M42-A nrPDB 195 2e-50 2I6L-A nrPDB 195 2e-50 3HNG-A nrPDB 195 3e-50 5LPZ-A nrPDB 195 3e-50 2A1A-B nrPDB 195 3e-50 3NIE-A nrPDB 194 4e-50 2WTK-C nrPDB 194 4e-50 1TKI-A nrPDB 194 6e-50 5UIU-A nrPDB 193 7e-50 5Y86-A nrPDB 193 1e-49 3QA8-A nrPDB 192 1e-49 3PG1-A nrPDB 192 2e-49 3ORP-A nrPDB 190 6e-49 3UIU-A nrPDB 190 8e-49 5LPV-A nrPDB 189 2e-48 3UIM-A nrPDB 188 2e-48 5X8I-B nrPDB 188 2e-48 5ZTN-A nrPDB 188 3e-48 4X7Q-B nrPDB 188 4e-48 2Y4I-B nrPDB 188 4e-48 4KIK-B nrPDB 188 4e-48 2RIO-A nrPDB 187 6e-48 6O6Q-A nrPDB 187 6e-48 2BUJ-A nrPDB 187 7e-48 3LMG-A nrPDB 187 8e-48 4TPT-A nrPDB 186 1e-47 6FYV-A nrPDB 185 2e-47 5TQX-A nrPDB 185 3e-47 4FL3-A nrPDB 184 4e-47 4EQM-A nrPDB 183 8e-47 5AR8-A nrPDB 183 9e-47 2WTK-B nrPDB 183 1e-46 4IDT-A nrPDB 182 1e-46 6J5U-C nrPDB 182 2e-46 6CTH-A nrPDB 182 3e-46 5C26-A nrPDB 181 3e-46 5WNO-A nrPDB 181 4e-46 2PMN-X nrPDB 179 1e-45 4Y83-A nrPDB 178 3e-45 3ZZW-A nrPDB 178 3e-45 3Q4U-A nrPDB 177 9e-45 4G3E-A nrPDB 176 1e-44 6HV0-A nrPDB 175 2e-44 2WO6-A nrPDB 175 2e-44 3RAW-A nrPDB 175 2e-44 3MDY-A nrPDB 175 3e-44 5VC6-A nrPDB 174 6e-44 4PL5-B nrPDB 173 6e-44 5UNP-A nrPDB 173 8e-44 4MD7-E nrPDB 173 1e-43 2PVN-A nrPDB 172 2e-43 6HMD-A nrPDB 170 6e-43 6EII-A nrPDB 169 1e-42 3MY0-A nrPDB 169 1e-42 4JLC-A nrPDB 169 2e-42 3QD2-B nrPDB 168 2e-42 4EUU-A nrPDB 168 3e-42 5TE0-A nrPDB 167 6e-42 4EUT-A nrPDB 167 7e-42 3SOC-A nrPDB 165 2e-41 3LLT-A nrPDB 165 2e-41 2QKW-B nrPDB 165 2e-41 6O8B-A nrPDB 164 4e-41 1PY5-A nrPDB 164 4e-41 6NT9-A nrPDB 164 4e-41 5XD6-A nrPDB 163 7e-41 5IKW-A nrPDB 162 1e-40 5XVU-A nrPDB 162 2e-40 4OW8-A nrPDB 162 2e-40 4X3F-A nrPDB 162 2e-40 6B2Q-A nrPDB 161 3e-40 2JD5-A nrPDB 161 3e-40 5J0A-A nrPDB 161 4e-40 4M66-A nrPDB 161 4e-40 4TN6-A nrPDB 160 1e-39 4CRL-A nrPDB 160 1e-39 3SV0-A nrPDB 160 1e-39 5FQD-C nrPDB 158 2e-39 4MWI-A nrPDB 158 3e-39 5E8V-A nrPDB 158 4e-39 3VHK-A nrPDB 157 5e-39 6BFN-A nrPDB 156 1e-38 4BTK-A nrPDB 155 3e-38 4LFI-A nrPDB 155 3e-38 4NFN-A nrPDB 154 5e-38 2CHL-A nrPDB 151 3e-37 4LQP-A nrPDB 151 5e-37 2H34-A nrPDB 150 1e-36 4IAN-A nrPDB 149 2e-36 2CMW-A nrPDB 146 9e-36 2C47-A nrPDB 146 1e-35 2QLU-A nrPDB 146 1e-35 4M69-B nrPDB 146 2e-35 4BTF-A nrPDB 145 2e-35 4L00-A nrPDB 145 3e-35 4XHH-A nrPDB 144 7e-35 3G2F-A nrPDB 143 9e-35 4RT7-A nrPDB 140 1e-33 4F9B-A nrPDB 138 5e-33 5X18-A nrPDB 137 7e-33 5L2Q-C nrPDB 132 2e-31 6DC0-A nrPDB 130 1e-30 5CEK-A nrPDB 130 1e-30 5C01-A nrPDB 123 9e-29 4WOV-A nrPDB 122 2e-28 2PZI-A nrPDB 121 3e-28 4Y12-A nrPDB 121 4e-28 4L68-A nrPDB 118 4e-27 5UV4-A nrPDB 116 1e-26 5M07-A nrPDB 116 2e-26 4OAU-C nrPDB 104 6e-23 4JRN-A nrPDB 104 7e-23 4CI6-B nrPDB 98 5e-21 5CLR-A nrPDB 93 1e-19 Sequences not found previously or not previously below threshold: 2J90-A nrPDB 242 2e-64 5VDK-A nrPDB 159 2e-39 2X7G-A nrPDB 146 9e-36 4WUA-A nrPDB 145 2e-35 4NT4-A nrPDB 136 1e-32 4XHL-A nrPDB 135 3e-32 1CSN-A nrPDB 134 6e-32 5USZ-A nrPDB 131 4e-31 3REP-A nrPDB 129 2e-30 5X1R-A nrPDB 120 9e-28 5OAT-A nrPDB 111 4e-25 4I94-A nrPDB 106 1e-23 6J6I-B nrPDB 102 3e-22 6EQI-C nrPDB 98 4e-21 4O1O-A nrPDB 93 2e-19 5UU1-A nrPDB 82 3e-16 2RSV-A nrPDB 82 3e-16 2LAV-A nrPDB 80 1e-15 4IX6-A nrPDB 80 2e-15 6EAS-A nrPDB 73 1e-13 6G4J-A nrPDB 71 4e-13 2JII-A nrPDB 68 4e-12 5DMZ-A nrPDB 66 3e-11 6BHC-A nrPDB 65 4e-11 6EWX-A nrPDB 65 6e-11 5GZA-A nrPDB 62 4e-10 5GZ9-A nrPDB 61 9e-10 6M7Z-A nrPDB 61 1e-09 3BYV-A nrPDB 57 1e-08 4CYJ-A nrPDB 57 1e-08 3DZO-A nrPDB 54 1e-07 6G38-A nrPDB 51 5e-07 4AZV-A nrPDB 50 2e-06 4AZW-A nrPDB 50 2e-06 2W1Z-A nrPDB 49 3e-06 4BWP-A nrPDB 48 6e-06 4CZY-B nrPDB 46 2e-05 5VE6-A nrPDB 46 3e-05 3Q60-A nrPDB 41 6e-04 4WWA-A nrPDB 40 0.001 5YK0-A nrPDB 40 0.002 3QRQ-A nrPDB 38 0.006 3ENH-A nrPDB 37 0.013 6G18-v nrPDB 35 0.053 3URH-A nrPDB 34 0.059 1ZP9-A nrPDB 34 0.063 6FDN-A nrPDB 34 0.080 1TQM-A nrPDB 34 0.11 2PZ1-A nrPDB 34 0.11 5ER0-A nrPDB 33 0.15 3E46-A nrPDB 33 0.17 6EF6-A nrPDB 33 0.22 >3VN9-A nrPDB Length = 340 Score = 473 bits (1219), Expect = e-134, Method: Composition-based stats. Identities = 334/334 (100%), Positives = 334/334 (100%) Query: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG Sbjct: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60 Query: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF Sbjct: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV Sbjct: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 Query: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI Sbjct: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 Query: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK Sbjct: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD Sbjct: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 >3FME-A nrPDB Length = 290 Score = 405 bits (1041), Expect = e-113, Method: Composition-based stats. Identities = 286/290 (98%), Positives = 287/290 (98%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 + EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 60 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD VAK IDAGCKPYMAPER Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPER 180 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS Sbjct: 181 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 240 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD Sbjct: 241 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 290 >3ALO-A nrPDB Length = 327 Score = 335 bits (860), Expect = 1e-92, Method: Composition-based stats. Identities = 171/293 (58%), Positives = 219/293 (74%), Gaps = 4/293 (1%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 Q+++ A+DL+ + E+GRGAYG V KM H PSGQIMAVKRIR+TV+ +EQK+LLMDLD+ Sbjct: 15 QHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVV 74 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSI 162 MR+ DCP+ V FYGALFREGD WICMELM TS DKFYK V IPE+ILGKI ++ Sbjct: 75 MRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLAT 134 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 VKAL HL L +IHRD+KPSN+L++ G +K+CDFGISG LVDS+AKT DAGC+PYMAP Sbjct: 135 VKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAP 194 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP--- 279 ERI+P +++GY V+SD+WSLGIT+ ELA RFPY W + F QL QVV+ PQL Sbjct: 195 ERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSE 254 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLIL 332 +FS F++F + CL K+ +RP Y EL++HPF ++E + +VA +V IL Sbjct: 255 EREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKIL 307 >5B2L-A nrPDB Length = 324 Score = 297 bits (761), Expect = 4e-81, Method: Composition-based stats. Identities = 139/300 (46%), Positives = 199/300 (66%), Gaps = 5/300 (1%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKR 95 ++IG Q ++ + +DLE + E+G G G V KMR +G ++AVK++R + N +E KR Sbjct: 2 TGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKR 61 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 +LMDLD+ +++ DCP+ V +G DV+I MELM TS +K K++ IPE IL Sbjct: 62 ILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQG---PIPERIL 118 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAG 215 GK+ V+IVKAL +L K VIHRDVKPSN+L++ GQ+K+CDFGISG LVDS AKT AG Sbjct: 119 GKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAG 178 Query: 216 CKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 C YMAPERI+P K Y +++D+WSLGI+++ELA +FPY + T F+ L +V++E Sbjct: 179 CAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEE 238 Query: 275 SPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG 333 P LP FS +F F CL K+ ++RP Y +L++H F +E+ DVAS+ K ++ Sbjct: 239 PPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMA 298 >3COM-A nrPDB Length = 314 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 106/308 (34%), Positives = 164/308 (53%), Gaps = 20/308 (6%) Query: 19 AFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI 78 + E Q + P R L S+ Q EV + + +LG G+YG V K H +GQI Sbjct: 1 SLETVQLRNPPRRQLKKLDEDSLTKQPEEV----FDVLEKLGEGSYGSVYKAIHKETGQI 56 Query: 79 MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDK 138 +A+K++ + QE ++ ++ I M+ D P V +YG+ F+ D+WI ME Sbjct: 57 VAIKQVPVESDLQE---IIKEISI-MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS 112 Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 ++ + +T+ ED + I S +K LE+LH + IHRD+K N+L+N G K+ DF Sbjct: 113 DIIRL--RNKTLTEDEIATILQSTLKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLADF 169 Query: 199 GISGYLVDSVAKTIDA-GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 G++G L D++AK G +MAPE I + GY+ +DIWSLGIT IE+A + PY Sbjct: 170 GVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITAIEMAEGKPPY 225 Query: 258 DSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 P + + + P P + +S F DF QCL K+ ++R T +L+QHPF + Sbjct: 226 ADIH-PMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPF--V 282 Query: 317 HESKGTDV 324 +KG + Sbjct: 283 RSAKGVSI 290 >4AN9-A nrPDB Length = 301 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 118/287 (41%), Positives = 178/287 (62%), Gaps = 10/287 (3%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 63 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P+ V FYGA + +G++ ICME MD QV+ K IPE ILGK++++++K L Sbjct: 64 CNSPYIVGFYGAFYSDGEISICMEHMDGG---SLDQVLKKAGRIPEQILGKVSIAVIKGL 120 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+D +A G + YM+PER Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-NEFVGTRSYMSPER-- 177 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 L YSV+SDIWS+G++++E+A+ R+P F+ L +V EP P+LP+ FS E Sbjct: 178 --LQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAI-FELLDYIVNEPPPKLPSAVFSLE 234 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG 333 F DF ++CL KN ER +LM H F +++ D A ++ +G Sbjct: 235 FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 281 >3DXN-A nrPDB Length = 287 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 125/284 (44%), Gaps = 20/284 (7%) Query: 40 SIGNQNFEVK--ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRL 96 S G +N + +D + + +LG GAYG V + +G A+K I+ + V + Sbjct: 8 SSGRENLYFQGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGA 67 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 L+D ++ +D P + Y + + ++ ME+ + + ++I + Q E Sbjct: 68 LLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILR-QKFSEVDAA 124 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTID 213 I ++ +LH K +++HRD+KP N+L+ + + +K+ DFG+S + Sbjct: 125 VIMKQVLSGTTYLH-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKER 183 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G Y+APE + +K Y K D+WS G+ + L P+ G Q++ + VE+ Sbjct: 184 LGTAYYIAPEVL-----RKKYDEKCDVWSCGVILYILLCGYPPF--GGQTDQEILKRVEK 236 Query: 274 PSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + S E L +R + E + HP+ Sbjct: 237 GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >4LG4-A nrPDB Length = 299 Score = 269 bits (687), Expect = 1e-72, Method: Composition-based stats. Identities = 94/269 (34%), Positives = 150/269 (55%), Gaps = 14/269 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 + + + +LG G+YG V K H SGQ++A+K++ + QE ++ ++ I M+ D Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE---IIKEISI-MQQCD 64 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P+ V +YG+ F+ D+WI ME ++ + +T+ ED + I S +K LE+ Sbjct: 65 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL--RNKTLIEDEIATILKSTLKGLEY 122 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA-GCKPYMAPERINP 227 LH + IHR++K N+L+N G K+ DFG++G L D++AK G +MAPE I Sbjct: 123 LHF-MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-- 179 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAE 286 + GY+ +DIWSLGIT IE+A + PY P + + + P P + +S + Sbjct: 180 --QEIGYNCVADIWSLGITSIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPELWSDD 236 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 F DF +CL KN ++R T +L+QHPF Sbjct: 237 FTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >3HZT-A nrPDB Length = 467 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 124/283 (43%), Gaps = 19/283 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVD 108 +D + + +LG GAYG V + +G A+K I+ + V + L+D ++ +D Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + Y + + ++ ME+ + + ++I + Q E I ++ + Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILR-QKFSEVDAAVIMKQVLSGTTY 119 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 LH K +++HRD+KP N+L+ + + +K+ DFG+S + G Y+APE + Sbjct: 120 LH-KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL 178 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF-- 283 +K Y K D+WS G+ + L P+ G Q++ + VE+ + Sbjct: 179 -----RKKYDEKCDVWSCGVILYILLCGYPPF--GGQTDQEILKRVEKGKFSFDPPDWTQ 231 Query: 284 -SAEFVDFTSQCLKKNSKERPTYPELMQHPFF-TLHESKGTDV 324 S E L +R + E + HP+ K TDV Sbjct: 232 VSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDV 274 >4MVF-A nrPDB Length = 506 Score = 267 bits (682), Expect = 7e-72, Method: Composition-based stats. Identities = 77/280 (27%), Positives = 123/280 (43%), Gaps = 17/280 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D +LG+G YG V K + Q+ A+K + + R +++I M+ +D P Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKD-RLKNINRFFQEIEI-MKKLDHP 114 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V Y + +++ MEL + + +I+ G + E I I A+ +LH Sbjct: 115 NIVKLYETYENDNYIYLIMELCSG--RELFDSIIENG-SFTEKNAATIMKQIFSAIFYLH 171 Query: 171 SKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 S L+++HRD+KP N L N +K+ DFG+S L T AG Y+AP+ ++ Sbjct: 172 S-LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG 230 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK--FSA 285 Y K DIWS G+ M L P+ T + LK+V + D S+ Sbjct: 231 -----KYDKKCDIWSSGVIMYTLLCGYPPFY-GDTDNEVLKKVKKGEFCFYENDWGSISS 284 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVA 325 + + ++ L N ER T E + HP+ T V Sbjct: 285 DAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVE 324 >6AO5-A nrPDB Length = 362 Score = 266 bits (681), Expect = 7e-72, Method: Composition-based stats. Identities = 94/269 (34%), Positives = 150/269 (55%), Gaps = 14/269 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 + + + +LG G+YG V K H SGQ++A+K++ + QE ++ ++ I M+ D Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE---IIKEISI-MQQCD 63 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P+ V +YG+ F+ D+WI ME ++ + +T+ ED + I S +K LE+ Sbjct: 64 SPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL--RNKTLIEDEIATILKSTLKGLEY 121 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA-GCKPYMAPERINP 227 LH + IHR++K N+L+N G K+ DFG++G L D++AK G +MAPE I Sbjct: 122 LHF-MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-- 178 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAE 286 + GY+ +DIWSLGIT IE+A + PY P + + + P P + +S + Sbjct: 179 --QEIGYNCVADIWSLGITSIEMAEGKPPYADIH-PMRAIFMIPTNPPPTFRKPELWSDD 235 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 F DF +CL KN ++R T +L+QHPF Sbjct: 236 FTDFVKKCLVKNPEQRATATQLLQHPFIK 264 >3LIJ-A nrPDB Length = 494 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 135/295 (45%), Gaps = 18/295 (6%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91 DL + + I ++ + ++ + + +LG GAYG V R + A+K IR T S Sbjct: 19 DLQATPGMFITSKKGHL-SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVST 77 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 L++ ++ +D P + Y + + ++ ME + + ++I + + Sbjct: 78 SSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGG--ELFDEIIHRMK-FN 134 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSV 208 E I ++ + +LH K +++HRD+KP N+L+ + +K+ DFG+S + Sbjct: 135 EVDAAVIIKQVLSGVTYLH-KHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQK 193 Query: 209 AKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLK 268 G Y+APE + +K Y K D+WS+G+ + L P+ G Q++ Sbjct: 194 KMKERLGTAYYIAPEVL-----RKKYDEKCDVWSIGVILFILLAGYPPF--GGQTDQEIL 246 Query: 269 QVVEEPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 + VE+ + ++ S D Q L+ +S+ R + + ++HP+ SK Sbjct: 247 RKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSK 301 >4CSV-A nrPDB Length = 275 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 125/273 (45%), Gaps = 18/273 (6%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 + +E+ ++ +LG G +G V + + +AVK ++ S E+ L + I Sbjct: 3 HDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE--FLQEAQI 60 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVS 161 M+ + P V YG +E ++I E M SL + + +G T+ L +A Sbjct: 61 -MKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDC--EGHTVNAQALLDMAAQ 117 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---P 218 + + +L S+ + IHRD+ N L+ VK+ DFG++ L++ T AG K Sbjct: 118 VASGMAYLESQ-NFIHRDLAARNCLVGENNVVKVADFGLAR-LINEDEYTARAGAKFPIK 175 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQ 277 + APE I+ +S+KSD+W+ GI + E+ + PY G ++ + VE Sbjct: 176 WTAPEAIS----YNRFSIKSDVWAFGILLWEIFTYGQVPYP--GMSGSEVIEQVERGYRM 229 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 E + QC K+ +ERPT+ E + Sbjct: 230 PRPQGCPEEIYELMLQCWNKSPEERPTFAETLH 262 >2VZ6-A nrPDB Length = 313 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 139/295 (47%), Gaps = 20/295 (6%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQK 94 + + +G +N ++ + ELG+GA+ VV + V +GQ A K I +++++ + Sbjct: 8 SSGVDLGTENLYFQSM-YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ 66 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI 154 +L + I R + P V + ++ EG ++ +L+ + ++ ++ + + E Sbjct: 67 KLEREARI-CRLLKHPNIVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAR-EYYSEAD 122 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKT 211 I++A+ H H ++ V+HRD+KP N+L+ + + VK+ DFG++ + Sbjct: 123 ASHCIQQILEAVLHCH-QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 181 Query: 212 I-DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 AG Y++PE + + Y D+W+ G+ + L + P+ W +L Q Sbjct: 182 FGFAGTPGYLSPEVLR----KDPYGKPVDLWACGVILYILLVGYPPF--WDEDQHRLYQQ 235 Query: 271 VEEPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 ++ + P D + E D ++ L N +R T E ++HP+ + + + Sbjct: 236 IKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVAS 290 >5KCV-A nrPDB Length = 460 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 131/313 (41%), Gaps = 19/313 (6%) Query: 11 PGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKM 70 GLK A ++ S + +S+ V ++ E + LG+G +G V + Sbjct: 122 DGLKKQAAAEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILV 181 Query: 71 RHVPSGQIMAVKRIRATVN--SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWIC 128 + +G+ A+K ++ V E L + + ++ PF + + Sbjct: 182 KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV-LQNSRHPFLTALKYSFQTHDRLCFV 240 Query: 129 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN 188 ME + F+ + + + ED IV AL++LHS+ +V++RD+K N++++ Sbjct: 241 MEYANGGELFFH---LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD 297 Query: 189 ALGQVKMCDFGISGY-LVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 G +K+ DFG+ + D G Y+APE L Y D W LG+ M Sbjct: 298 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV----LEDNDYGRAVDWWGLGVVM 353 Query: 248 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP---- 303 E+ R P+ + ++L +++ + P E S LKK+ K+R Sbjct: 354 YEMMCGRLPF--YNQDHEKLFELILMEEIRFPR-TLGPEAKSLLSGLLKKDPKQRLGGGS 410 Query: 304 -TYPELMQHPFFT 315 E+MQH FF Sbjct: 411 EDAKEIMQHRFFA 423 >5IG1-A nrPDB Length = 344 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 127/279 (45%), Gaps = 19/279 (6%) Query: 52 DLEPIM-ELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDC 109 DL+ +G+GA+ V + + +G++ AVK I ++ S E ++ ++ I ++ Sbjct: 17 DLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGI-CSSLQH 75 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V+ A E ++ E + + + +++ + + E I+ AL+H Sbjct: 76 EHIVSMRRAFRDESHFYLVFEYVSGG--ELFDEIVTR-KFYNEKDASACMHQILSALQHC 132 Query: 170 HSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 HSK ++IHRD+KP N+L+ + VK+ DFG++ + AG Y++PE I Sbjct: 133 HSK-NIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIR 191 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADKF 283 + Y D+W+ G+ + L + P+ W Q+L ++ P D Sbjct: 192 ----RVPYDTAVDVWACGVILYILLVGYPPF--WEEDHQKLYAQIKNCQYDFPSPEWDSV 245 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + + L+ N K RPT EL+QHP+ + G+ Sbjct: 246 TTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGS 284 >4QMW-A nrPDB Length = 310 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 84/289 (29%), Positives = 142/289 (49%), Gaps = 14/289 (4%) Query: 42 GNQNFEVKADD-LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 G QN + ++ + ++G+G++G V K + +++A+K I E + + ++ Sbjct: 19 GMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEI 78 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + + D P+ +YG+ ++ +WI ME + + + E + I Sbjct: 79 TV-LSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP----GPLDETQIATILR 133 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT-IDAGCKPY 219 I+K L++LHS+ + HRD+K +NVL++ G+VK+ DFG++G L D+ K G + Sbjct: 134 EILKGLDYLHSEKKI-HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFW 192 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 MAPE I Q Y K+DIWSLGIT IELA P+ P + L + + P L Sbjct: 193 MAPEVIK----QSAYDSKADIWSLGITAIELARGEPPHSELH-PMKVLFLIPKNNPPTL- 246 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 +S +F CL K RPT EL++H F + K + + + Sbjct: 247 EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI 295 >3NCG-A nrPDB Length = 486 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 133/301 (44%), Gaps = 22/301 (7%) Query: 40 SIGNQNFEVK---ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 S G +N + A+ + LG+G++G V K + + Q AVK I +A+ +++ Sbjct: 8 SSGRENLYFQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTST 67 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 +L +++ ++ +D P + + L +I EL + + ++I + + E Sbjct: 68 ILREVE-LLKKLDHPNIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKR-KRFSEHDA 123 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTI 212 +I + + ++H K +++HRD+KP N+L+ + +K+ DFG+S + Sbjct: 124 ARIIKQVFSGITYMH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKD 182 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+APE + Y K D+WS G+ + L P+ +G + + VE Sbjct: 183 RIGTAYYIAPEVLRGT-----YDEKCDVWSAGVILYILLSGTPPF--YGKNEYDILKRVE 235 Query: 273 EPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVK 329 ++ S + D + L + R T + ++HP+ + S+ ++ Sbjct: 236 TGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPS 295 Query: 330 L 330 L Sbjct: 296 L 296 >3MN3-A nrPDB Length = 271 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 123/266 (46%), Gaps = 12/266 (4%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCP 110 + + + LG G++G V+ H +GQ +A+K I V ++ + ++ +IS +R + P Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 + Y + + ++ + +E ++ + ++ + + + E + I+ A+E+ H Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYAG---NELFDYIVQRDK-MSEQEARRFFQQIISAVEYCH 120 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 ++HRD+KP N+L++ VK+ DFG+S + D G Y APE I+ +L Sbjct: 121 RH-KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLY 179 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + D+WS G+ + + R P+D P L + + LP S Sbjct: 180 A---GPEVDVWSCGVILYVMLCRRLPFDDESIPV--LFKNISNGVYTLP-KFLSPGAAGL 233 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTL 316 + L N R + E+MQ +F + Sbjct: 234 IKRMLIVNPLNRISIHEIMQDDWFKV 259 >2V7O-A nrPDB Length = 336 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 136/303 (44%), Gaps = 27/303 (8%) Query: 36 KACISIGNQNFEVKA--------DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-A 86 + + +G +N ++ DD + ELG+GA+ VV + Q A K I Sbjct: 8 SSGVDLGTENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTK 67 Query: 87 TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK 146 +++++ ++L + I R + P V + ++ EG ++ +L+ + ++ ++ + Sbjct: 68 KLSARDHQKLEREARI-CRLLKHPNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAR 124 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGY 203 + E I++++ H+H ++HRD+KP N+L+ + + VK+ DFG++ Sbjct: 125 -EYYSEADASHCIHQILESVNHIHQH-DIVHRDLKPENLLLASKCKGAAVKLADFGLAIE 182 Query: 204 LVDSVAKTI-DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262 + AG Y++PE + + Y DIW+ G+ + L + P+ W Sbjct: 183 VQGEQQAWFGFAGTPGYLSPEVLR----KDPYGKPVDIWACGVILYILLVGYPPF--WDE 236 Query: 263 PFQQLKQVVEEPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 +L Q ++ + P D + E + +Q L N +R T + ++HP+ + Sbjct: 237 DQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRST 296 Query: 320 KGT 322 + Sbjct: 297 VAS 299 >2FO0-A nrPDB Length = 495 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 130/300 (43%), Gaps = 16/300 (5%) Query: 28 TPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT 87 P R+ + +S +E++ D+ +LG G YG V + +AVK ++ Sbjct: 194 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE- 252 Query: 88 VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDK 146 ++ E + L + + M+ + P V G RE +I E M +L + ++ Sbjct: 253 -DTMEVEEFLKEAAV-MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR- 309 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 Q + +L +A I A+E+L K + IHR++ N L+ VK+ DFG+S + Sbjct: 310 -QEVNAVVLLYMATQISSAMEYL-EKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTG 367 Query: 207 SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTP 263 P + APE + +S+KSD+W+ G+ + E+A PY G Sbjct: 368 DTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYP--GID 421 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 Q+ +++E+ + + + C + N +RP++ E+ Q ES +D Sbjct: 422 LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 481 >2XIK-A nrPDB Length = 294 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 87/291 (29%), Positives = 143/291 (49%), Gaps = 14/291 (4%) Query: 40 SIGNQNFEVKADD-LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98 NQ+ V ++ + +G+G++G V K + +++A+K I E + + Sbjct: 7 GFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQ 66 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 ++ + + D P+ ++G+ + +WI ME + K + E + I Sbjct: 67 EITV-LSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL----KPGPLEETYIATI 121 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT-IDAGCK 217 I+K L++LHS+ + HRD+K +NVL++ G VK+ DFG++G L D+ K G Sbjct: 122 LREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTP 180 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 +MAPE I Q Y K+DIWSLGIT IELA P +S P + L + + P Sbjct: 181 FWMAPEVIK----QSAYDFKADIWSLGITAIELAKGEPP-NSDLHPMRVLFLIPKNSPPT 235 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 L S F +F CL K+ + RPT EL++H F T + K + + + Sbjct: 236 LEGQH-SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELI 285 >5KKR-C nrPDB Length = 395 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 119/328 (36%), Positives = 180/328 (54%), Gaps = 50/328 (15%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 64 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 122 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P+ V FYGA + +G++ ICME MD QV+ K IPE ILGK++++++K L Sbjct: 123 CNSPYIVGFYGAFYSDGEISICMEHMDGG---SLDQVLKKAGRIPEQILGKVSIAVIKGL 179 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER Sbjct: 180 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPER-- 236 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP----------------------- 263 L YSV+SDIWS+G++++E+A+ R+P Sbjct: 237 --LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 294 Query: 264 ------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 295 PGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADL 354 Query: 306 PELMQHPFFTLHESKGTDVASFVKLILG 333 +LM H F +++ D A ++ +G Sbjct: 355 KQLMVHAFIKRSDAEEVDFAGWLCSTIG 382 >2BDW-A nrPDB Length = 362 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 130/280 (46%), Gaps = 18/280 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVD 108 +D+ + ELG+GA+ VV + H +G A K I +++++ ++L + I R + Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARI-CRKLQ 86 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V + ++ E ++ +L+ + ++ ++ + + E I++++ + Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAR-EFYSEADASHCIQQILESIAY 143 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 HS ++HR++KP N+L+ + + VK+ DFG++ + DS A AG Y++PE Sbjct: 144 CHSN-GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV- 201 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADK 282 L + YS DIW+ G+ + L + P+ W +L ++ + P D Sbjct: 202 ---LKKDPYSKPVDIWACGVILYILLVGYPPF--WDEDQHRLYAQIKAGAYDYPSPEWDT 256 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + E L N K+R T + ++ P+ E + Sbjct: 257 VTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVAS 296 >2VN9-A nrPDB Length = 301 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 133/280 (47%), Gaps = 19/280 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDC 109 D+ + ELG+GA+ VV + +P+GQ A K I +++++ ++L + I R + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARI-CRLLKH 62 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V + ++ EG ++ +L+ + ++ ++ + + E I++++ H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILESVNHC 119 Query: 170 HSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERI 225 H ++HRD+KP N+L+ + + VK+ DFG++ + D A AG Y++PE + Sbjct: 120 HLN-GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 178 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADK 282 + Y D+W+ G+ + L + P+ W +L Q ++ + P D Sbjct: 179 R----KDPYGKPVDMWACGVILYILLVGYPPF--WDEDQHRLYQQIKAGAYDFPSPEWDT 232 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + E D ++ L N +R T E ++HP+ + + Sbjct: 233 VTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVAS 272 >5D7A-A nrPDB Length = 308 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 95/289 (32%), Positives = 142/289 (49%), Gaps = 15/289 (5%) Query: 35 SKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK 94 I A E + +G G YG V K RHV +GQ+ A+K + T + E++ Sbjct: 1 GSGADEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD--EEE 58 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGD------VWICMELMD-TSLDKFYKQVIDKG 147 + ++++ + T+YGA ++ +W+ ME S+ K KG Sbjct: 59 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT--KG 116 Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS 207 T+ E+ + I I++ L HLH VIHRD+K NVL+ +VK+ DFG+S L + Sbjct: 117 NTLKEEWIAYICREILRGLSHLHQH-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 175 Query: 208 VAKT-IDAGCKPYMAPERINPELN-QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 V + G +MAPE I + N Y KSD+WSLGIT IE+A P P + Sbjct: 176 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMH-PMR 234 Query: 266 QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 L + P+P+L + K+S +F F CL KN +RP +LM+HPF Sbjct: 235 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFI 283 >4XEY-B nrPDB Length = 408 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 130/300 (43%), Gaps = 16/300 (5%) Query: 28 TPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT 87 P R+ + +S +E++ D+ +LG G YG V + +AVK ++ Sbjct: 102 APKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE- 160 Query: 88 VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDK 146 ++ E + L + + M+ + P V G RE +I E M +L + ++ Sbjct: 161 -DTMEVEEFLKEAAV-MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR- 217 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 Q + +L +A I A+E+L K + IHRD+ N L+ VK+ DFG+S + Sbjct: 218 -QEVNAVVLLYMATQISSAMEYL-EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 275 Query: 207 SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTP 263 P + APE + +S+KSD+W+ G+ + E+A PY G Sbjct: 276 DTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYP--GID 329 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 Q+ +++E+ + + + C + N +RP++ E+ Q ES +D Sbjct: 330 LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 389 >2UV2-A nrPDB Length = 325 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 86/302 (28%), Positives = 151/302 (50%), Gaps = 23/302 (7%) Query: 36 KACISIGNQNFEVKA--------------DDLEPIMELGRGAYGVVEKMRHVPSGQIMAV 81 + + +G +N ++ D E I ELG GA+G V K ++ + + A Sbjct: 8 SSGVDLGTENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAA 67 Query: 82 KRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYK 141 K I T + +E + ++++DI + + D P V A + E ++WI +E Sbjct: 68 KVI-DTKSEEELEDYMVEIDI-LASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVM 125 Query: 142 QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS 201 +++ + E + + + AL +LH +IHRD+K N+L G +K+ DFG+S Sbjct: 126 LELER--PLTESQIQVVCKQTLDALNYLHDN-KIIHRDLKAGNILFTLDGDIKLADFGVS 182 Query: 202 GYLVDSVAKTIDA-GCKPYMAPERINPELNQ-KGYSVKSDIWSLGITMIELAILRFPYDS 259 ++ + G +MAPE + E ++ + Y K+D+WSLGIT+IE+A + P+ Sbjct: 183 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHE 242 Query: 260 WGTPFQQLKQVVEEPSPQL-PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 P + L ++ + P L ++S+ F DF +CL+KN R T +L+QHPF T+ Sbjct: 243 L-NPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDS 301 Query: 319 SK 320 +K Sbjct: 302 NK 303 >3DFA-A nrPDB Length = 286 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 130/291 (44%), Gaps = 22/291 (7%) Query: 40 SIGNQNFEVK---ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 S G +N + A+ + LG+G++G V K + + Q AVK I +A+ +++ Sbjct: 8 SSGRENLYFQGTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTST 67 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 +L +++ ++ +D P + + L +I EL + + ++I + + E Sbjct: 68 ILREVE-LLKKLDHPNIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKR-KRFSEHDA 123 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTI 212 +I + + ++H K +++HRD+KP N+L+ + +K+ DFG+S + Sbjct: 124 ARIIKQVFSGITYMH-KHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKD 182 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+APE + Y K D+WS G+ + L P+ +G + + VE Sbjct: 183 RIGTAYYIAPEVLRGT-----YDEKCDVWSAGVILYILLSGTPPF--YGKNEYDILKRVE 235 Query: 273 EPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 ++ S + D + L + R T + ++HP+ + S+ Sbjct: 236 TGKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >3H4J-B nrPDB Length = 336 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 122/262 (46%), Gaps = 12/262 (4%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPFTVTF 115 LG G++G V+ H + Q +A+K I + + + ++ +IS ++ + P + Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 116 YGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 Y + D+ + +E + + +++K + + ED + I+ A+E+ H + Sbjct: 75 YDVITTPTDIVMVIEYAGG---ELFDYIVEK-KRMTEDEGRRFFQQIICAIEYCHRH-KI 129 Query: 176 IHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 +HRD+KP N+L++ VK+ DFG+S + D G Y APE IN +L Sbjct: 130 VHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYA---G 186 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 + D+WS GI + + + R P+D P L + V +P D S + + Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFDDEFIPN--LFKKVNSCVYVMP-DFLSPGAQSLIRRMI 243 Query: 296 KKNSKERPTYPELMQHPFFTLH 317 + +R T E+ + P+F ++ Sbjct: 244 VADPMQRITIQEIRRDPWFNVN 265 >5FG8-A nrPDB Length = 285 Score = 260 bits (666), Expect = 4e-70, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 129/281 (45%), Gaps = 19/281 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVD 108 +D+ + ELG+GA+ +V++ +G A K I + +++ ++L + I R + Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARI-CRKLH 71 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V + ++ E ++ +L+ + ++ ++ + + E I++++ H Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGG--ELFEDIVAR-EFYSEADASHCIQQILESVNH 128 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLV-DSVAKTIDAGCKPYMAPER 224 H V+HRD+KP N+L+ + + VK+ DFG++ + D A AG Y++PE Sbjct: 129 CHQN-GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEV 187 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---AD 281 + E Y DIW+ G+ + L + P+ W +L ++ + P D Sbjct: 188 LKKE----PYGKSVDIWACGVILYILLVGYPPF--WDEDQHRLYSQIKAGAYDYPSPEWD 241 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + E + +Q L N +R T E ++HP+ E + Sbjct: 242 TVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVAS 282 >3KK8-A nrPDB Length = 284 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 130/280 (46%), Gaps = 18/280 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVD 108 +D+ + ELG+GA+ VV + H +G A K I +++++ ++L + I R + Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARI-CRKLQ 63 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V + ++ E ++ +L+ + ++ ++ + + E I++++ + Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAR-EFYSEADASHCIQQILESIAY 120 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 HS ++HR++KP N+L+ + + VK+ DFG++ + DS A AG Y++PE Sbjct: 121 CHSN-GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV- 178 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADK 282 L + YS DIW+ G+ + L + P+ W +L ++ + P D Sbjct: 179 ---LKKDPYSKPVDIWACGVILYILLVGYPPF--WDEDQHRLYAQIKAGAYDYPSPEWDT 233 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + E L N K+R T + ++ P+ E + Sbjct: 234 VTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVAS 273 >3EQC-A nrPDB Length = 360 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 119/328 (36%), Positives = 180/328 (54%), Gaps = 50/328 (15%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K+ H PSG +MA K I + + +++ +L + + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHE 87 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P+ V FYGA + +G++ ICME MD QV+ K IPE ILGK++++++K L Sbjct: 88 CNSPYIVGFYGAFYSDGEISICMEHMDGG---SLDQVLKKAGRIPEQILGKVSIAVIKGL 144 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YM+PER Sbjct: 145 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPER-- 201 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP----------------------- 263 L YSV+SDIWS+G++++E+A+ R+P Sbjct: 202 --LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRT 259 Query: 264 ------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 F+ L +V EP P+LP+ FS EF DF ++CL KN ER Sbjct: 260 PGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADL 319 Query: 306 PELMQHPFFTLHESKGTDVASFVKLILG 333 +LM H F +++ D A ++ +G Sbjct: 320 KQLMVHAFIKRSDAEEVDFAGWLCSTIG 347 >2WQN-A nrPDB Length = 310 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 153/306 (50%), Gaps = 25/306 (8%) Query: 8 KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67 +++ G++ P QPQ + P ++ A + ++GRG + V Sbjct: 3 EQSQGMQGPPVPQFQPQKALRPDMGYNTLA--------------NFRIEKKIGRGQFSEV 48 Query: 68 EKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV 125 + + G +A+K+++ ++++ + + ++D ++ ++ P + +Y + + ++ Sbjct: 49 YRAACLLDGVPVALKKVQIFDLMDAKARADCIKEID-LLKQLNHPNVIKYYASFIEDNEL 107 Query: 126 WICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 I +EL D L + K + + IPE + K V + ALEH+HS+ V+HRD+KP+N Sbjct: 108 NIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSR-RVMHRDIKPAN 166 Query: 185 VLINALGQVKMCDFGISGYLVD-SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSL 243 V I A G VK+ D G+ + + A G YM+PERI ++ GY+ KSDIWSL Sbjct: 167 VFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI----HENGYNFKSDIWSL 222 Query: 244 GITMIELAILRFPYDSWGTPFQQLKQVVEEP-SPQLPADKFSAEFVDFTSQCLKKNSKER 302 G + E+A L+ P+ L + +E+ P LP+D +S E + C+ + ++R Sbjct: 223 GCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKR 282 Query: 303 PTYPEL 308 P + Sbjct: 283 PDVTYV 288 >5JN2-A nrPDB Length = 525 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 124/293 (42%), Gaps = 22/293 (7%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTV 107 +D + LG+G++G V + +GQ AVK I R +++ LL ++ ++ + Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQ-LLKQL 124 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 D P + Y +G ++ E+ + + ++I + + E +I ++ + Sbjct: 125 DHPNIMKLYEFFEDKGYFYLVGEVYTGG--ELFDEIISR-KRFSEVDAARIIRQVLSGIT 181 Query: 168 HLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 ++H K ++HRD+KP N+L+ + +++ DFG+S + S G Y+APE Sbjct: 182 YMH-KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 240 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---AD 281 + Y K D+WS G+ + L P++ G + + VE+ Sbjct: 241 L-----HGTYDEKCDVWSTGVILYILLSGCPPFN--GANEYDILKKVEKGKYTFELPQWK 293 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK--GTDVASFVKLIL 332 K S D + L R + + + H + + + DV S IL Sbjct: 294 KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAIL 346 >2BPM-A nrPDB Length = 309 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 75/295 (25%), Positives = 125/295 (42%), Gaps = 33/295 (11%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107 V ++ + + ++G G YGVV K R+ +G+++A+K+IR ++ + ++ + Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 63 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + P V + E +++ E + L KF G +P ++ +++ L Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP--LIKSYLFQLLQGLA 121 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERIN 226 HS V+HRD+KP N+LIN G +K+ DFG++ V T + Y APE + Sbjct: 122 FCHSH-RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL- 179 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPS--------- 275 L K YS DIWSLG E+ R FP DS ++ + + P Sbjct: 180 --LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 276 --------PQLPADKFSAEF-------VDFTSQCLKKNSKERPTYPELMQHPFFT 315 P+ FS SQ L + +R + + HPFF Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 292 >3MV5-A nrPDB Length = 342 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN--SQEQKRLLMD 99 G + V ++ E + LG+G +G V ++ +G+ A+K ++ V E L + Sbjct: 1 GAMDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE 60 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + ++ PF + + ME + F+ + + + ED Sbjct: 61 NRV-LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH---LSRERVFSEDRARFYG 116 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKP 218 IV AL++LHS+ +V++RD+K N++++ G +K+ DFG+ + D G Sbjct: 117 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 176 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Y+APE L Y D W LG+ M E+ R P+ + ++L +++ + Sbjct: 177 YLAPEV----LEDNDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHEKLFELILMEEIRF 230 Query: 279 PADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFFT 315 P E S LKK+ K+R E+MQH FF Sbjct: 231 PR-TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 271 >3IS5-A nrPDB Length = 285 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 68/285 (23%), Positives = 131/285 (45%), Gaps = 18/285 (6%) Query: 40 SIGNQNFEVK--ADDLEPIM-ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 S G +N + DDL +LG GA+G V + SG +K I + +++ Sbjct: 8 SSGRENLYFQGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQI 67 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID---KGQTIPED 153 ++++ ++++D P + + +++I ME + + ++++ +G+ + E Sbjct: 68 EAEIEV-LKSLDHPNIIKIFEVFEDYHNMYIVMETCEGG--ELLERIVSAQARGKALSEG 124 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAK 210 + ++ ++ AL + HS+ V+H+D+KP N+L +K+ DFG++ Sbjct: 125 YVAELMKQMMNALAYFHSQ-HVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS 183 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 T AG YMAPE + + K DIWS G+ M L P+ Q K Sbjct: 184 TNAAGTALYMAPEVFK-----RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKAT 238 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +EP+ + + + VD Q L K+ + RP+ +++ H +F Sbjct: 239 YKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >5U6Y-A nrPDB Length = 461 Score = 256 bits (655), Expect = 7e-69, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 131/278 (47%), Gaps = 19/278 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDCPF 111 + ELG+GA+ VV + V +GQ A K I +++++ ++L + I R + P Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI-CRLLKHPN 60 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V + ++ EG ++ +L+ + ++ ++ + + E I++A+ H H Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILEAVLHCH- 116 Query: 172 KLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTI-DAGCKPYMAPERINP 227 ++ V+HRD+KP N+L+ + + VK+ DFG++ + AG Y++PE + Sbjct: 117 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR- 175 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADKFS 284 + Y D+W+ G+ + L + P+ W +L Q ++ + P D + Sbjct: 176 ---KDPYGKPVDLWACGVILYILLVGYPPF--WDEDQHRLYQQIKAGAYDFPSPEWDTVT 230 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 E D ++ L N +R T E ++HP+ + + + Sbjct: 231 PEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVAS 268 >6HXF-B nrPDB Length = 302 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 91/282 (32%), Positives = 151/282 (53%), Gaps = 15/282 (5%) Query: 43 NQNFEVKADDL------EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 ++ +E DL E + ELG GA+G V K ++ +G + A K I T + +E + Sbjct: 5 SREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVI-ETKSEEELEDY 63 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 +++++I + T D P+ V GA + +G +WI +E +D+G + E + Sbjct: 64 IVEIEI-LATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRG--LTEPQIQ 120 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA-G 215 + +++AL LHSK +IHRD+K NVL+ G +++ DFG+S + ++ K G Sbjct: 121 VVCRQMLEALNFLHSK-RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIG 179 Query: 216 CKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 +MAPE + E + Y K+DIWSLGIT+IE+A + P+ P + L ++ + Sbjct: 180 TPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL-NPMRVLLKIAKSD 238 Query: 275 SPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P L K+S EF DF L KN + RP+ +L++HPF + Sbjct: 239 PPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVS 280 >2JC6-A nrPDB Length = 334 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 127/298 (42%), Gaps = 21/298 (7%) Query: 43 NQNFEVKADD----LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98 + +++ +A+D E LG GA+ V +G++ AVK I ++ + Sbjct: 10 SSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIEN 69 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 ++ + +R + V +++ M+L+ + + ++++KG E + Sbjct: 70 EIAV-LRKIKHENIVALEDIYESPNHLYLVMQLVSGG--ELFDRIVEKGFY-TEKDASTL 125 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAG 215 ++ A+ +LH ++ ++HRD+KP N+L + ++ + DFG+S + G Sbjct: 126 IRQVLDAVYYLH-RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACG 184 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 Y+APE + QK YS D WS+G+ L P+ + +L + + + Sbjct: 185 TPGYVAPEVLA----QKPYSKAVDCWSIGVIAYILLCGYPPF--YDENDSKLFEQILKAE 238 Query: 276 PQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKL 330 + D S DF ++K+ +R T + +HP+ + ++ V Sbjct: 239 YEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSA 296 >3DAK-A nrPDB Length = 290 Score = 256 bits (654), Expect = 9e-69, Method: Composition-based stats. Identities = 87/289 (30%), Positives = 139/289 (48%), Gaps = 25/289 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 + + DD E +G GA VV+ P + +A+KRI LL ++ +M Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQ-AMS 63 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQT----IPEDILGKIAV 160 P V++Y + + ++W+ M+L+ S+ K ++ KG+ + E + I Sbjct: 64 QCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL------VDSVAKTIDA 214 +++ LE+LH K IHRDVK N+L+ G V++ DFG+S +L + + Sbjct: 124 EVLEGLEYLH-KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G +MAPE + +GY K+DIWS GIT IELA PY + P + L ++ Sbjct: 183 GTPCWMAPEVME---QVRGYDFKADIWSFGITAIELATGAAPYHKY-PPMKVLMLTLQND 238 Query: 275 SPQLPA--------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P L K+ F S CL+K+ ++RPT EL++H FF Sbjct: 239 PPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQ 287 >4FZF-B nrPDB Length = 283 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 82/281 (29%), Positives = 135/281 (48%), Gaps = 13/281 (4%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 + + +G+G++G V K + Q++A+K I E + + ++ + + D Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV-LSQCD 64 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + +YG+ + +WI ME + + E + + I+K L++ Sbjct: 65 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL----RAGPFDEFQIATMLKEILKGLDY 120 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT-IDAGCKPYMAPERINP 227 LHS+ + HRD+K +NVL++ G VK+ FG++G L D+ K G +MAPE I Sbjct: 121 LHSEKKI-HRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-- 177 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 Q Y K+DIWSLGIT IELA P +S P + L + + P L D F+ F Sbjct: 178 --QQSAYDSKADIWSLGITAIELAKGEPP-NSDMHPMRVLFLIPKNNPPTLVGD-FTKSF 233 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 +F CL K+ RPT EL++H F + K + + + Sbjct: 234 KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELI 274 >4CFF-A nrPDB Length = 571 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 116/275 (42%), Gaps = 13/275 (4%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDL 100 + VK LG G +G V+ H +G +AVK + + ++ ++ Sbjct: 25 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 84 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +++ P + Y + D ++ ME + + + + G+ + E ++ Sbjct: 85 Q-NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGR-VEEMEARRLFQ 140 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+ A+++ H + V+HRD+KP NVL++A K+ DFG+S + D G Y Sbjct: 141 QILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 APE I+ L + DIWS G+ + L P+D P L + + +P Sbjct: 200 APEVISGRLYA---GPEVDIWSCGVILYALLCGTLPFDDEHVPT--LFKKIRGGVFYIP- 253 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + L+ + +R T ++ +H +F Sbjct: 254 EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 288 >5ES1-A nrPDB Length = 328 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 124/266 (46%), Gaps = 12/266 (4%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCP 110 + + +G+G + V+ RH+ +G+ +A+K I T +N ++L ++ I M+ ++ P Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRI-MKGLNHP 74 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + + E +++ ME + + ++ G+ + E IV A+ + H Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASAG--EVFDYLVSHGR-MKEKEARAKFRQIVSAVHYCH 131 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 K +++HRD+K N+L++A +K+ DFG S G PY APE Sbjct: 132 QK-NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQ---G 187 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 +K + DIWSLG+ + L P+D G ++L++ V ++P S + Sbjct: 188 KKYDGPEVDIWSLGVILYTLVSGSLPFD--GHNLKELRERVLRGKYRVPF-YMSTDCESI 244 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTL 316 + L N +R T ++M+ + + Sbjct: 245 LRRFLVLNPAKRCTLEQIMKDKWINI 270 >4FIE-A nrPDB Length = 423 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 85/331 (25%), Positives = 155/331 (46%), Gaps = 25/331 (7%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 Q G P P+ +PQ S + + G+ L+ +++G G Sbjct: 110 QENGMPEKP--PGPRSPQREPQRVSHEQFRAALQLVVDPGD-----PRSYLDNFIKIGEG 162 Query: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122 + G+V SG+++AVK++ + Q+++ LL + + MR V Y + Sbjct: 163 STGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVG 220 Query: 123 GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKP 182 ++W+ ME ++ ++ + + E+ + + +++++AL LH++ VIHRD+K Sbjct: 221 DELWVVMEFLEGGA---LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKS 275 Query: 183 SNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIW 241 ++L+ G+VK+ DFG + V + G +MAPE I+ + Y + DIW Sbjct: 276 DSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS----RLPYGPEVDIW 331 Query: 242 SLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQCLKKNSK 300 SLGI +IE+ PY + P + +K + + P+L K S F + L ++ Sbjct: 332 SLGIMVIEMVDGEPPYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 390 Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 +R T EL++HPF +K AS V L+ Sbjct: 391 QRATAAELLKHPFL----AKAGPPASIVPLM 417 >5KZ7-A nrPDB Length = 346 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 126/266 (47%), Gaps = 12/266 (4%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCP 110 + + +G+G + V+ RH+ +G+ +AVK I T +NS ++L ++ I M+ ++ P Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRI-MKVLNHP 92 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + + E +++ ME + + ++ G+ + E IV A+++ H Sbjct: 93 NIVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 149 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 K ++HRD+K N+L++A +K+ DFG S G PY APE Sbjct: 150 QKF-IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQ---G 205 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 +K + D+WSLG+ + L P+D G ++L++ V ++P S + + Sbjct: 206 KKYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPF-YMSTDCENL 262 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTL 316 + L N +R T ++M+ + + Sbjct: 263 LKKFLILNPSKRGTLEQIMKDRWMNV 288 >4EBW-A nrPDB Length = 304 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 128/296 (43%), Gaps = 17/296 (5%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHV---PSGQIMAVKRIRATV 88 +L + + +++E++ + +E +G G +G V + ++ +A+K + Sbjct: 19 NLYFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT 78 Query: 89 NSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQ 148 + +++ L + ++MR D P V G + E VWI MEL + + QV + Sbjct: 79 SDSVREKFLQEA-LTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQV--RKY 134 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 ++ L A + AL +L SK +HRD+ NVL+++ VK+ DFG+S Y+ DS Sbjct: 135 SLDLASLILYAYQLSTALAYLESK-RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST 193 Query: 209 AKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQ 265 G P +MAPE I N + ++ SD+W G+ M E+ + P+ G Sbjct: 194 YYKASKGKLPIKWMAPESI----NFRRFTSASDVWMFGVCMWEILMHGVKPFQ--GVKNN 247 Query: 266 QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 + +E ++C + RP + EL L E K Sbjct: 248 DVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKA 303 >5EZV-A nrPDB Length = 560 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 116/275 (42%), Gaps = 13/275 (4%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDL 100 + VK LG G +G V+ H +G +AVK + + ++ ++ Sbjct: 20 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 79 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +++ P + Y + D ++ ME + + + + G+ + E ++ Sbjct: 80 Q-NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGR-VEEMEARRLFQ 135 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+ A+++ H + V+HRD+KP NVL++A K+ DFG+S + D G Y Sbjct: 136 QILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 194 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 APE I+ L + DIWS G+ + L P+D P L + + +P Sbjct: 195 APEVISGRLYA---GPEVDIWSCGVILYALLCGTLPFDDEHVPT--LFKKIRGGVFYIP- 248 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + L+ + +R T ++ +H +F Sbjct: 249 EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 283 >3BHH-A nrPDB Length = 295 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 132/280 (47%), Gaps = 19/280 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDC 109 D+ + ++G+GA+ VV + + +G A K I +++++ ++L + I R + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARI-CRLLKH 62 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V + ++ EG ++ +L+ + ++ ++ + + E I++A+ H Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILEAVLHC 119 Query: 170 HSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERI 225 H ++ V+HRD+KP N+L+ + + VK+ DFG++ + D A AG Y++PE + Sbjct: 120 H-QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 178 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADK 282 E Y DIW+ G+ + L + P+ W +L Q ++ + P D Sbjct: 179 RKE----AYGKPVDIWACGVILYILLVGYPPF--WDEDQHKLYQQIKAGAYDFPSPEWDT 232 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + E + +Q L N +R T E ++HP+ + + Sbjct: 233 VTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVAS 272 >6FD3-A nrPDB Length = 300 Score = 253 bits (646), Expect = 8e-68, Method: Composition-based stats. Identities = 82/284 (28%), Positives = 138/284 (48%), Gaps = 21/284 (7%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKR 95 ++ +S+G+ ++G+GA G V + +GQ +A+K++ + Q +K Sbjct: 12 RSIVSVGD-----PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN--LQQQPKKE 64 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDI 154 L+++ + MR P V + + ++W+ ME + SL + + E Sbjct: 65 LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-----MDEGQ 119 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID- 213 + + ++AL+ LHS VIHRD+K N+L+ G VK+ DFG + +K Sbjct: 120 IAAVCRECLQALDFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 178 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G +MAPE + +K Y K DIWSLGI IE+ PY + P + L + Sbjct: 179 VGTPYWMAPEVV----TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE-NPLRALYLIATN 233 Query: 274 PSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 +P+L ++ SA F DF ++CL+ + R + EL+QHPF L Sbjct: 234 GTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL 277 >4REW-A nrPDB Length = 540 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 115/270 (42%), Gaps = 13/270 (4%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISMR 105 VK LG G +G V+ +H +G +AVK + + ++ ++ +++ Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQ-NLK 61 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 P + Y + D+++ ME + + + + G+ + E ++ I+ Sbjct: 62 LFRHPHIIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGR-LDEKESRRLFQQILSG 118 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 +++ H + V+HRD+KP NVL++A K+ DFG+S + D G Y APE I Sbjct: 119 VDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 177 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 + L + DIWS G+ + L P+D P L + + + + Sbjct: 178 SGRLYA---GPEVDIWSSGVILYALLCGTLPFDDDHVPT--LFKKICDG-IFYTPQYLNP 231 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + L+ + +R + ++ +H +F Sbjct: 232 SVISLLKHMLQVDPMKRASIKDIREHEWFK 261 >5WAX-A nrPDB Length = 310 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 124/269 (46%), Gaps = 15/269 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D E + ++G G +GV MR+ GQ++AVK I + + + ++ I+ R++ P Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI--ERGEKIDENVQREI-INHRSLRHP 67 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 + F + + I ME + ++++ + G+ ED ++ + + H Sbjct: 68 NIIRFKEVILTPTHLAIVMEYASGG--ELFERICNAGR-FSEDEARFFFQQLISGVSYCH 124 Query: 171 SKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 S + V HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 125 S-MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL--- 180 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-KFSA 285 L ++ +D+WS G+T+ + + +P++ P F++ Q + +P S Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISP 240 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFF 314 E D S+ N R T PE+ HP+F Sbjct: 241 ECQDLISRIFVANPATRITIPEIRNHPWF 269 >4UZD-A nrPDB Length = 287 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 73/277 (26%), Positives = 128/277 (46%), Gaps = 15/277 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE--QKRLLMDLDISMRTVD 108 +D E LG+G +G V R S I+A+K + + + +L +++I + Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSH-LR 66 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + YG V++ +E L Y+++ + E + AL + Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAP--LGTVYRELQKLSK-FDEQRTATYITELANALSY 123 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 HSK VIHRD+KP N+L+ + G++K+ DFG S + S +T G Y+ PE I Sbjct: 124 CHSK-RVIHRDIKPENLLLGSAGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGR 181 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 + + K D+WSLG+ E + + P++ +Q+ + + P D + Sbjct: 182 M----HDEKVDLWSLGVLCYEFLVGKPPFE--ANTYQETYKRISRVEFTFP-DFVTEGAR 234 Query: 289 DFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVA 325 D S+ LK N +RP E+++HP+ T + SK ++ Sbjct: 235 DLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQ 271 >4FG9-A nrPDB Length = 320 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 125/286 (43%), Gaps = 17/286 (5%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 D + LG GA+ V + +++A+K I ++ + ++ + + + Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAV-LHKIKH 75 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V G +++ M+L+ + + ++++KG E ++ ++ A+++L Sbjct: 76 PNIVALDDIYESGGHLYLIMQLVSGG--ELFDRIVEKGFY-TERDASRLIFQVLDAVKYL 132 Query: 170 HSKLSVIHRDVKPSNVL---INALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 H L ++HRD+KP N+L ++ ++ + DFG+S + G Y+APE + Sbjct: 133 HD-LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLA 191 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADKF 283 QK YS D WS+G+ L P+ + +L + + + + D Sbjct: 192 ----QKPYSKAVDCWSIGVIAYILLCGYPPF--YDENDAKLFEQILKAEYEFDSPYWDDI 245 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVK 329 S DF ++K+ ++R T + +QHP+ + ++ V Sbjct: 246 SDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVS 291 >5J5T-A nrPDB Length = 370 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 89/283 (31%), Positives = 142/283 (50%), Gaps = 12/283 (4%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 +D E I +G G YG V K R+V +G++ A+K I+ + E ++ I M+ P Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK--LEPGEDFAVVQQEIIMMKDCKHP 61 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V ++G+ R +WICME + + + E + ++ ++ L +LH Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGG---SLQDIYHVTGPLSELQIAYVSRETLQGLYYLH 118 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT-IDAGCKPYMAPERINPEL 229 SK +HRD+K +N+L+ G VK+ DFG+S + ++AK G +MAPE E Sbjct: 119 SKGK-MHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE- 176 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE---EPSPQLPADKFSAE 286 + GY+ D+W++GIT IELA L+ P P + L + + +P K+S Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLH-PMRALFLMTKSNFQPPKLKDKMKWSNS 235 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVK 329 F F L KN K+RPT +L+QHPF T H ++ + K Sbjct: 236 FHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDK 278 >4JDH-A nrPDB Length = 346 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 85/331 (25%), Positives = 155/331 (46%), Gaps = 25/331 (7%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 Q G P P+ +PQ S + + G+ L+ +++G G Sbjct: 33 QENGMPEKP--PGPRSPQREPQRVSHEQFRAALQLVVDPGD-----PRSYLDNFIKIGEG 85 Query: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE 122 + G+V SG+++AVK++ + Q+++ LL + + MR V Y + Sbjct: 86 STGIVCIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVG 143 Query: 123 GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKP 182 ++W+ ME ++ ++ + + E+ + + +++++AL LH++ VIHRD+K Sbjct: 144 DELWVVMEFLEGGA---LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKS 198 Query: 183 SNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIW 241 ++L+ G+VK+ DFG + V + G +MAPE I+ + Y + DIW Sbjct: 199 DSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS----RLPYGPEVDIW 254 Query: 242 SLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQCLKKNSK 300 SLGI +IE+ PY + P + +K + + P+L K S F + L ++ Sbjct: 255 SLGIMVIEMVDGEPPYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPA 313 Query: 301 ERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 +R T EL++HPF +K AS V L+ Sbjct: 314 QRATAAELLKHPFL----AKAGPPASIVPLM 340 >2QNJ-A nrPDB Length = 328 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 126/272 (46%), Gaps = 13/272 (4%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCP 110 + + +G+G + V+ RH+ +G+ +A+K I T +N ++L ++ I M+ ++ P Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI-MKILNHP 71 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + + E +++ ME + + ++ G+ + E IV A+++ H Sbjct: 72 NIVKLFEVIETEKTLYLIMEYASGG--EVFDYLVAHGR-MKEKEARSKFRQIVSAVQYCH 128 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 K ++HRD+K N+L++A +K+ DFG S G PY APE Sbjct: 129 QK-RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQ---G 184 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 +K + D+WSLG+ + L P+D G ++L++ V ++P S + + Sbjct: 185 KKYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPF-YMSTDCENL 241 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTL-HESKG 321 + L N +R T ++M+ + HE Sbjct: 242 LKRFLVLNPIKRGTLEQIMKDRWINAGHEEDE 273 >3MA6-A nrPDB Length = 298 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 62/302 (20%), Positives = 124/302 (41%), Gaps = 33/302 (10%) Query: 40 SIGNQNFEVK-------------ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-- 84 S G +N + +D + LG+G++G V + +GQ AVK I Sbjct: 8 SSGRENLYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISK 67 Query: 85 RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVI 144 R +++ LL ++ ++ +D P + Y +G ++ E+ + + ++I Sbjct: 68 RQVKQKTDKESLLREVQ-LLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGG--ELFDEII 124 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGIS 201 + + E +I ++ + ++H K ++HRD+KP N+L+ + +++ DFG+S Sbjct: 125 SR-KRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLLLESKSKDANIRIIDFGLS 182 Query: 202 GYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG 261 + S G Y+APE + Y K D+WS G+ + L P++ G Sbjct: 183 THFEASKKMKDKIGTAYYIAPEVL-----HGTYDEKCDVWSTGVILYILLSGCPPFN--G 235 Query: 262 TPFQQLKQVVEEPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 + + VE+ K S D + L R + + + H + + Sbjct: 236 ANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYT 295 Query: 319 SK 320 + Sbjct: 296 KE 297 >3SOA-A nrPDB Length = 444 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 132/280 (47%), Gaps = 19/280 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR-ATVNSQEQKRLLMDLDISMRTVDC 109 ++ + ELG+GA+ VV + V +GQ A I +++++ ++L + I R + Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARI-CRLLKH 69 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V + ++ EG ++ +L+ + ++ ++ + + E I++A+ H Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAR-EYYSEADASHCIQQILEAVLHC 126 Query: 170 HSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTI-DAGCKPYMAPERI 225 H ++ V+HR++KP N+L+ + + VK+ DFG++ + AG Y++PE + Sbjct: 127 H-QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADK 282 + Y D+W+ G+ + L + P+ W +L Q ++ + P D Sbjct: 186 R----KDPYGKPVDLWACGVILYILLVGYPPF--WDEDQHRLYQQIKAGAYDFPSPEWDT 239 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + E D ++ L N +R T E ++HP+ + + + Sbjct: 240 VTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVAS 279 >5D9K-A nrPDB Length = 330 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 144/304 (47%), Gaps = 24/304 (7%) Query: 22 QPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHV---PSGQI 78 PQT +++ + G++ + E + LG+G++G V ++ + + Q+ Sbjct: 3 NPQTEEVSIKEIAITHHVKEGHE--KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQL 60 Query: 79 MAVKRIRA-TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLD 137 A+K ++ T+ +++ R M+ DI + V+ PF V + A EG +++ ++ + Sbjct: 61 YAMKVLKKATLKVRDRVRTKMERDI-LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG-- 117 Query: 138 KFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 + + + K E+ + + AL+HLHS L +I+RD+KP N+L++ G +K+ D Sbjct: 118 DLFTR-LSKEVMFTEEDVKFYLAELALALDHLHS-LGIIYRDLKPENILLDEEGHIKLTD 175 Query: 198 FGISGYLVDSVAK-TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP 256 FG+S +D K G YMAPE + N++G++ +D WS G+ M E+ P Sbjct: 176 FGLSKESIDHEKKAYSFCGTVEYMAPEVV----NRRGHTQSADWWSFGVLMFEMLTGTLP 231 Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY-----PELMQH 311 + G ++ ++ + +P S E K+N R E+ +H Sbjct: 232 FQ--GKDRKETMTMILKAKLGMP-QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRH 288 Query: 312 PFFT 315 FF+ Sbjct: 289 SFFS 292 >1S9I-A nrPDB Length = 354 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 117/331 (35%), Positives = 178/331 (53%), Gaps = 54/331 (16%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 E+K DD E I ELG G GVV K++H PSG IMA K I + + +++ +L + + Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHE 70 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P+ V FYGA + +G++ ICME MD QV+ + + IPE+ILGK+++++++ L Sbjct: 71 CNSPYIVGFYGAFYSDGEISICMEHMDGG---SLDQVLKEAKRIPEEILGKVSIAVLRGL 127 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 +L K ++HRDVKPSN+L+N+ G++K+CDFG+SG L+DS+A + G + YMAPER Sbjct: 128 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMAPER-- 184 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP----------------------- 263 L YSV+SDIWS+G++++ELA+ R+P Sbjct: 185 --LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISP 242 Query: 264 ----------------------FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKE 301 F+ L +V EP P+LP F+ +F +F ++CL KN E Sbjct: 243 RPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAE 302 Query: 302 RPTYPELMQHPFFTLHESKGTDVASFVKLIL 332 R L H F E + D A ++ L Sbjct: 303 RADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 333 >3TT0-A nrPDB Length = 382 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 31/293 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKM------RHVPSG-QIMAVKRIRATVNSQEQKR 95 + +E+ D L LG GA+G V + P+ +AVK +++ ++ Sbjct: 61 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSD 120 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-------------DTSLDKFYKQ 142 L+ ++++ + GA ++G +++ +E L+ Y Sbjct: 121 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNP 180 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + + L A + + +E+L SK IHRD+ NVL+ +K+ DFG++ Sbjct: 181 SHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLAR 239 Query: 203 YLVD-SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 + K G P +MAPE L + Y+ +SD+WS G+ + E+ PY Sbjct: 240 DIHHIDYYKKTTNGRLPVKWMAPE----ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 295 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 296 --GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >5YKS-A nrPDB Length = 377 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 76/279 (27%), Positives = 123/279 (44%), Gaps = 15/279 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 + LGRG + VV+ RHV +G+ +AVK I T L M+ V P Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V Y + + +++ +EL D + ++ + + ED+ K IV A+ + H K Sbjct: 97 VRLYEVIDTQTKLYLILELGDGG--DMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH-K 153 Query: 173 LSVIHRDVKPSN-VLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 L V+HRD+KP N V G VK+ DFG S T G Y APE + L Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEIL---LGD 210 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 + + DIWSLG+ + L + P+ + ++ + +P+ S E D Sbjct: 211 EYDAPAVDIWSLGVILFMLVCGQPPFQEANDS--ETLTMIMDCKYTVPS-HVSKECKDLI 267 Query: 292 SQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKL 330 ++ L+++ K R + E+ HP+ +G D + K Sbjct: 268 TRMLQRDPKRRASLEEIENHPWL-----QGVDPSPATKY 301 >2JDO-A nrPDB Length = 342 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 68/280 (24%), Positives = 124/280 (44%), Gaps = 18/280 (6%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDL 100 G + +V +D + + LG+G +G V +R +G+ A+K +R + ++++ + Sbjct: 1 GAMDPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE 60 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 ++ PF A + ME + F+ + + + E+ Sbjct: 61 SRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH---LSRERVFTEERARFYGA 117 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPY 219 IV ALE+LHS+ V++RD+K N++++ G +K+ DFG+ + D G Y Sbjct: 118 EIVSALEYLHSR-DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEY 176 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +APE L Y D W LG+ M E+ R P+ + ++L +++ + P Sbjct: 177 LAPEV----LEDNDYGRAVDWWGLGVVMYEMMCGRLPF--YNQDHERLFELILMEEIRFP 230 Query: 280 ADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 S E + LKK+ K+R E+M+H FF Sbjct: 231 R-TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >6NPU-A nrPDB Length = 298 Score = 250 bits (638), Expect = 8e-67, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 124/287 (43%), Gaps = 14/287 (4%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 S +E++ D+ +LG G YG V + +AVK ++ ++ E + L + Sbjct: 15 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKE--DTMEVEEFLKE 72 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + M+ + P V G RE +I E M Y + ++ Q + +L +A Sbjct: 73 AAV-MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMA 130 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP- 218 I A+E+L K + IHRD+ N L+ VK+ DFG+S + P Sbjct: 131 TQISSAMEYL-EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPI 189 Query: 219 -YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSP 276 + APE + +S+KSD+W+ G+ + E+A PY G Q+ +++E+ Sbjct: 190 KWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYP--GIDLSQVYELLEKDYR 243 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTD 323 + + + C + N +RP++ E+ Q ES +D Sbjct: 244 MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD 290 >3UC3-A nrPDB Length = 361 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 123/271 (45%), Gaps = 15/271 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 +D + + ++G G +GV MR + +++AVK I E + ++ I+ R++ Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDEN--VQREI-INHRSLR 74 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V F + + I ME + Y+++ + G+ ED ++ + + Sbjct: 75 HPNIVRFKEVILTPTHLAIIMEYASGG--ELYERICNAGR-FSEDEARFFFQQLLSGVSY 131 Query: 169 LHSKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 HS + + HRD+K N L++ ++K+CDFG S V G Y+APE + Sbjct: 132 CHS-MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 189 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-KF 283 L Q+ +D+WS G+T+ + + +P++ P +++ Q + +P D + Sbjct: 190 --LRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRI 247 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E S+ + R + PE+ H +F Sbjct: 248 SPECCHLISRIFVADPATRISIPEIKTHSWF 278 >4CFH-A nrPDB Length = 493 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 116/275 (42%), Gaps = 13/275 (4%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDL 100 + VK LG G +G V+ +H +G +AVK + + ++ ++ Sbjct: 25 KHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREI 84 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +++ P + Y + D+++ ME + + + + G+ + E ++ Sbjct: 85 Q-NLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGR-LDEKESRRLFQ 140 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+ +++ H + V+HRD+KP NVL++A K+ DFG+S + D G Y Sbjct: 141 QILSGVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 199 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 APE I+ L + DIWS G+ + L P+D P L + + + Sbjct: 200 APEVISGRLYA---GPEVDIWSSGVILYALLCGTLPFDDDHVPT--LFKKICDG-IFYTP 253 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + L+ + +R T ++ +H +F Sbjct: 254 QYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK 288 >5A46-A nrPDB Length = 386 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 122/293 (41%), Gaps = 31/293 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKM------RHVPSG-QIMAVKRIRATVNSQEQKR 95 + +E+ D L LG G +G V + P+ +AVK +++ ++ Sbjct: 32 DPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSD 91 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-------------DTSLDKFYKQ 142 L+ ++++ + GA ++G +++ +E L+ Y Sbjct: 92 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 151 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + + L A + + +E+L SK IHRD+ NVL+ +K+ DFG++ Sbjct: 152 SHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLAR 210 Query: 203 YLVD-SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 + K G P +MAPE L + Y+ +SD+WS G+ + E+ PY Sbjct: 211 DIHHIDYYKKTTNGRLPVKWMAPE----ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 266 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 267 --GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >4YZB-A nrPDB Length = 491 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 123/292 (42%), Gaps = 20/292 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVD 108 +D + LG+G++G V + +GQ AVK I + V + K LL+ ++ +D Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + Y +G ++ E+ + + ++I + + E +I ++ + + Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGG--ELFDEIISR-KRFSEVDAARIIRQVLSGITY 145 Query: 169 LHSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 +H K ++HRD+KP N+L+ +++ DFG+S + + G Y+APE + Sbjct: 146 MH-KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVL 204 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADK 282 Y K D+WS G+ + L P++ G + + VE+ K Sbjct: 205 -----HGTYDEKCDVWSTGVILYILLSGCPPFN--GANEFDILKKVEKGKFTFDLPQWKK 257 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES--KGTDVASFVKLIL 332 S D + L R + + ++H + ++ DV S IL Sbjct: 258 VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLESTIL 309 >2YZA-A nrPDB Length = 276 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 116/275 (42%), Gaps = 13/275 (4%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDL 100 + VK LG G +G V+ H +G +AVK + + ++ ++ Sbjct: 3 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 62 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +++ P + Y + D ++ ME + + + + G+ + E ++ Sbjct: 63 Q-NLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGR-VEEMEARRLFQ 118 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+ A+++ H + V+HRD+KP NVL++A K+ DFG+S + D G Y Sbjct: 119 QILSAVDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYA 177 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 APE I+ L + DIWS G+ + L P+D P L + + +P Sbjct: 178 APEVISGRLYA---GPEVDIWSCGVILYALLCGTLPFDDEHVPT--LFKKIRGGVFYIP- 231 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + L+ + +R T ++ +H +F Sbjct: 232 EYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFK 266 >3GQL-A nrPDB Length = 326 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 123/293 (41%), Gaps = 31/293 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKM------RHVPSG-QIMAVKRIRATVNSQEQKR 95 + +E+ D L LG GA+G V + P+ +AVK +++ ++ Sbjct: 20 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSD 79 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-------------DTSLDKFYKQ 142 L+ ++++ + GA ++G +++ +E L+ Y Sbjct: 80 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 139 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + + L A + + +E+L SK IHRD+ NVL+ +K+ DFG++ Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASK-KCIHRDLAARNVLVTEDNVMKIADFGLAR 198 Query: 203 YLVD-SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 + K G P +MAPE L + Y+ +SD+WS G+ + E+ PY Sbjct: 199 DIHHIDYYKKTTNGRLPVKWMAPE----ALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 254 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 255 --GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >3HDN-A nrPDB Length = 373 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 128/281 (45%), Gaps = 18/281 (6%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDL 100 + N K D + +G+G++G V RH AVK + +A + +E+K ++ + Sbjct: 30 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 89 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 ++ ++ V PF V + + ++ ++ ++ ++ Q + + E A Sbjct: 90 NVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQ---RERCFLEPRARFYAA 146 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPY 219 I AL +LHS L++++RD+KP N+L+++ G + + DFG+ + + + G Y Sbjct: 147 EIASALGYLHS-LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY 205 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +APE L+++ Y D W LG + E+ P+ S T + ++ +P P Sbjct: 206 LAPEV----LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNT-AEMYDNILNKPLQLKP 260 Query: 280 ADKFSAEFVDFTSQCLKKNSKERP----TYPELMQHPFFTL 316 + L+K+ +R + E+ H FF+L Sbjct: 261 --NITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSL 299 >1PHK-A nrPDB Length = 298 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 128/294 (43%), Gaps = 19/294 (6%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--------ATVNSQEQ 93 G+ + ++ EP LGRG VV + H P+ + AVK I A + + Sbjct: 8 GSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELR 67 Query: 94 KRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPED 153 + L ++DI + P + ++ +LM + + + +K T+ E Sbjct: 68 EATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKG--ELFDYLTEK-VTLSEK 124 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID 213 KI ++++ + LH KL+++HRD+KP N+L++ +K+ DFG S L Sbjct: 125 ETRKIMRALLEVICALH-KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREV 183 Query: 214 AGCKPYMAPERINPELNQK--GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G Y+APE I +N GY + D+WS G+ M L P+ W + +++ Sbjct: 184 CGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPF--WHRKQMLMLRMI 241 Query: 272 EEPSPQL---PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + Q D +S D S+ L ++R T E + HPFF + + Sbjct: 242 MSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQYVVEEV 295 >4RED-A nrPDB Length = 351 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 115/270 (42%), Gaps = 13/270 (4%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISMR 105 VK LG G +G V+ +H +G +AVK + + ++ ++ +++ Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQ-NLK 69 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 P + Y + D+++ ME + + + + G+ + E ++ I+ Sbjct: 70 LFRHPHIIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGR-LDEKESRRLFQQILSG 126 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 +++ H + V+HRD+KP NVL++A K+ DFG+S + D G Y APE I Sbjct: 127 VDYCHRHM-VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 + L + DIWS G+ + L P+D P L + + + + Sbjct: 186 SGRLYA---GPEVDIWSSGVILYALLCGTLPFDDDHVPT--LFKKICDG-IFYTPQYLNP 239 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + L+ + +R + ++ +H +F Sbjct: 240 SVISLLKHMLQVDPMKRASIKDIREHEWFK 269 >4XCU-A nrPDB Length = 300 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 117/280 (41%), Gaps = 22/280 (7%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMR-------HVPSGQIMAVKRIRATVNSQEQKRLLM 98 +E D L LG G +G V + +AVK ++ + ++ L+ Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 71 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMEL-MDTSLDKFYKQVIDKGQ---TIPEDI 154 ++++ + G +EG +++ +E +L +F + G + + Sbjct: 72 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPV 131 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD-SVAKTID 213 L A + + +++L S+ IHRD+ NVL+ +K+ DFG++ + K Sbjct: 132 LVSCAYQVARGMQYLESR-KCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 190 Query: 214 AGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQV 270 G P +MAPE L + Y+ +SD+WS GI + E+ PY G P ++L + Sbjct: 191 NGRLPVKWMAPE----ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYP--GIPVEELFSL 244 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + E E +C +RPT+ +L++ Sbjct: 245 LREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >3D2K-A nrPDB Length = 272 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 72/274 (26%), Positives = 128/274 (46%), Gaps = 15/274 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE--QKRLLMDLDISMRTVD 108 +D + LG+G +G V R S I+A+K + T + + +L +++I + Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSH-LR 70 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P + YG V++ +E L Y+++ + E + AL + Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAP--LGTVYRELQKLSR-FDEQRTATYITELANALSY 127 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 HSK VIHRD+KP N+L+ + G++K+ DFG S + S +T G Y+ PE I Sbjct: 128 CHSK-RVIHRDIKPENLLLGSNGELKIADFGWSVH-APSSRRTTLCGTLDYLPPEMIEGR 185 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 + + K D+WSLG+ E + P+++ +Q+ + + P D + Sbjct: 186 M----HDEKVDLWSLGVLCYEFLVGMPPFEAHT--YQETYRRISRVEFTFP-DFVTEGAR 238 Query: 289 DFTSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 D S+ LK N+ +R T E+++HP+ + SK + Sbjct: 239 DLISRLLKHNASQRLTLAEVLEHPWIKANSSKPS 272 >5XZW-A nrPDB Length = 471 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 117/279 (41%), Gaps = 20/279 (7%) Query: 50 ADDLEPI-MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 D I +G+GA+ V+K +G+ AVK I + +L++ ++ ++ Sbjct: 194 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEV-LQKLN 252 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V G ++ ME + V G + ED +I+ I+ A+++ Sbjct: 253 HPRIVRLKGFYEDTESYYMVMEFVSGG--DLMDFVAAHG-AVGEDAGREISRQILTAIKY 309 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 +HS + + HRD+KP N+LI VK+ DFG++ + G Y+APE I Sbjct: 310 IHS-MGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIR 368 Query: 227 PE---------LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + + YS D+WS+G + + P+ S T Q KQ+ + Sbjct: 369 GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF-SGSTQDQLYKQIGRGSYHE 427 Query: 278 LPADKF--SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 P F S E DF L+ + R T + + HP+ Sbjct: 428 GPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >6GQK-A nrPDB Length = 328 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 118/291 (40%), Gaps = 28/291 (9%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLL 97 + +E + L LG GA+G V + + +AVK ++ + +S E++ L+ Sbjct: 33 DHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALM 92 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQT------- 149 +L + + V GA G + E L F ++ D+ Sbjct: 93 SELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPED 152 Query: 150 -----IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 + + L + + K + L SK + IHRD+ N+L+ K+CDFG++ + Sbjct: 153 LYKDFLTLEHLLSFSYQVAKGMAFLASK-NCIHRDLAARNILLTHGNITKICDFGLARDI 211 Query: 205 VDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSW 260 + + +MAPE I + Y+ +SD+WS GI + EL PY Sbjct: 212 KNDSNYVDKGNARLPVKWMAPESIFNSV----YTFESDVWSYGIFLWELFSLGSSPYPGM 267 Query: 261 GTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + ++++E + AE D C + +RPT+ +++Q Sbjct: 268 PVD-SKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQD 317 >2XYN-A nrPDB Length = 292 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 121/284 (42%), Gaps = 24/284 (8%) Query: 36 KACISIGNQN--------FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT 87 + + +G +N +E++ D+ +LG G YG V +AVK ++ Sbjct: 9 SSGVDLGTENLYFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKE- 67 Query: 88 VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDK 146 ++ E + L + + M+ + P V G E +I E M +L + ++ Sbjct: 68 -DTMEVEEFLKEAAV-MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNR- 124 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 + + +L +A I A+E+L K + IHRD+ N L+ VK+ DFG+S + Sbjct: 125 -EEVTAVVLLYMATQISSAMEYL-EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 182 Query: 207 SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTP 263 P + APE + +S+KSD+W+ G+ + E+A PY G Sbjct: 183 DTYTAHAGAKFPIKWTAPESLA----YNTFSIKSDVWAFGVLLWEIATYGMSPYP--GID 236 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPE 307 Q+ ++E+ + + + C K + +RP++ E Sbjct: 237 LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 280 >4U41-A nrPDB Length = 332 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 95/292 (32%), Positives = 147/292 (50%), Gaps = 15/292 (5%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91 D +K+ + I + A E + +G G YG V K RHV +GQ+ A+K + V Sbjct: 5 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTED 62 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALF------REGDVWICMELMD-TSLDKFYKQVI 144 E++ + +++++ + T+YGA + +W+ ME S+ K Sbjct: 63 EEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT- 121 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 KG T+ ED + I+ I++ L HLH VIHRD+K NVL+ +VK+ DFG+S L Sbjct: 122 -KGNTLKEDWIAYISREILRGLAHLHIH-HVIHRDIKGQNVLLTENAEVKLVDFGVSAQL 179 Query: 205 VDSVAKT-IDAGCKPYMAPERINPELN-QKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262 +V + G +MAPE I + N Y +SD+WS GIT IE+A P Sbjct: 180 DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH- 238 Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 P + L + P P+L + K+S +F F CL KN +RP+ +L++HPF Sbjct: 239 PMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 290 >4XBR-A nrPDB Length = 366 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 151/317 (47%), Gaps = 23/317 (7%) Query: 17 KEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSG 76 + +PQ S + + G+ L+ +++G G+ G+V SG Sbjct: 65 RSPQREPQRVSHEQFRAALQLVVDPGD-----PRSYLDNFIKIGEGSTGIVCIATVRSSG 119 Query: 77 QIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSL 136 +++AVK++ + Q+++ LL + + MR V Y + ++W+ ME ++ Sbjct: 120 KLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGA 177 Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMC 196 ++ + + E+ + + +++++AL LH++ VIHRD+K ++L+ G+VK+ Sbjct: 178 ---LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLS 232 Query: 197 DFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 DFG + V + G +MAPE I+ + Y + DIWSLGI +IE+ Sbjct: 233 DFGFCAQVSKEVPRRKSLVGTPYWMAPELIS----RLPYGPEVDIWSLGIMVIEMVDGEP 288 Query: 256 PYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 PY + P + +K + + P+L K S F + L ++ +R T EL++HPF Sbjct: 289 PYFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 Query: 315 TLHESKGTDVASFVKLI 331 +K AS V L+ Sbjct: 348 ----AKAGPPASIVPLM 360 >5DBX-A nrPDB Length = 328 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 83/295 (28%), Positives = 140/295 (47%), Gaps = 25/295 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 + + D E +G GA VV+ P + +A+KRI LL ++ +M Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQ-AMS 64 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQT----IPEDILGKIAV 160 P VT+Y + + ++W+ M+L+ S+ K ++++G+ + E I+ I Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID------A 214 +++ L++LH IHRD+K N+L+ G V++ DFG+S +L T + Sbjct: 125 EVLEGLDYLHRN-GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G +MAPE + +GY K+D+WS GIT IELA PY + P + L ++ Sbjct: 184 GTPCWMAPEVME---QVRGYDFKADMWSFGITAIELATGAAPYHKY-PPMKVLMLTLQND 239 Query: 275 SPQLPA--------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 P L K+ F S CL+K+ +RPT EL++ FF +++ Sbjct: 240 PPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNRE 294 >2Q0N-A nrPDB Length = 301 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 150/315 (47%), Gaps = 23/315 (7%) Query: 19 AFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI 78 +PQ S + + G+ L+ +++G G+ G+V SG++ Sbjct: 2 PQREPQRVSHEQFRAALQLVVDPGD-----PRSYLDNFIKIGEGSTGIVCIATVRSSGKL 56 Query: 79 MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDK 138 +AVK++ + Q+++ LL + + MR V Y + ++W+ ME ++ Sbjct: 57 VAVKKM--DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGA-- 112 Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 ++ + + E+ + + +++++AL LH++ VIHRD+K ++L+ G+VK+ DF Sbjct: 113 -LTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQ-GVIHRDIKSDSILLTHDGRVKLSDF 169 Query: 199 GISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY 257 G + V + G +MAPE I+ + Y + DIWSLGI +IE+ PY Sbjct: 170 GFCAQVSKEVPRRKSLVGTPYWMAPELIS----RLPYGPEVDIWSLGIMVIEMVDGEPPY 225 Query: 258 DSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 + P + +K + + P+L K S F + L ++ +R T EL++HPF Sbjct: 226 FNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL-- 282 Query: 317 HESKGTDVASFVKLI 331 +K AS V L+ Sbjct: 283 --AKAGPPASIVPLM 295 >2JAM-A nrPDB Length = 304 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 126/287 (43%), Gaps = 19/287 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + LG GA+ V ++ +G++ A+K I+ + ++ L ++ + ++ + Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDS-SLENEIAV-LKKIKH 65 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 VT ++ M+L+ + + +++++G E + ++ A+++L Sbjct: 66 ENIVTLEDIYESTTHYYLVMQLVSGG--ELFDRILERG-VYTEKDASLVIQQVLSAVKYL 122 Query: 170 HSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 H ++HRD+KP N+L ++ + DFG+S + + + G Y+APE + Sbjct: 123 HEN-GIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLA 180 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---ADKF 283 QK YS D WS+G+ L P+ + +L + ++E + D Sbjct: 181 ----QKPYSKAVDCWSIGVITYILLCGYPPF--YEETESKLFEKIKEGYYEFESPFWDDI 234 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKL 330 S DF L+K+ ER T + + HP+ + + D+ V L Sbjct: 235 SESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSL 281 >2F57-A nrPDB Length = 317 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 72/270 (26%), Positives = 136/270 (50%), Gaps = 14/270 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 + L +++G G+ G+V +G+ +AVK++ + Q+++ LL + + MR Sbjct: 43 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM--DLRKQQRRELLFNEVVIMRDYH 100 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V Y + ++W+ ME ++ ++ + + E+ + + +S+++AL + Sbjct: 101 HDNVVDMYSSYLVGDELWVVMEFLEGGA---LTDIVTHTR-MNEEQIATVCLSVLRALSY 156 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINP 227 LH++ VIHRD+K ++L+ + G++K+ DFG + V K G +MAPE I+ Sbjct: 157 LHNQ-GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS- 214 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAE 286 + Y + DIWSLGI +IE+ PY + P Q ++++ + P++ K S+ Sbjct: 215 ---RLPYGTEVDIWSLGIMVIEMIDGEPPYFNE-PPLQAMRRIRDSLPPRVKDLHKVSSV 270 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 F L + +R T EL+ HPF L Sbjct: 271 LRGFLDLMLVREPSQRATAQELLGHPFLKL 300 >3ZUT-A nrPDB Length = 362 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 121/271 (44%), Gaps = 15/271 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 +D E + ++G G +GV MR S +++AVK I + + + ++ I+ R++ Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI--ERGEKIDENVKREI-INHRSLR 73 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V F + + I ME + ++++ + G+ ED ++ + + Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGR-FSEDEARFFFQQLISGVSY 130 Query: 169 LHSKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 H+ + V HRD+K N L++ ++K+C FG S V G Y+APE + Sbjct: 131 CHA-MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVL- 188 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-KF 283 L ++ +D+WS G+T+ + + +P++ P F++ + +P Sbjct: 189 --LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E S+ + +R + PE+ H +F Sbjct: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2J0K-A nrPDB Length = 656 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 124/284 (43%), Gaps = 17/284 (5%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSG---QIMAVKRIRATVNSQEQKRLLMD 99 +++E++ + +E +G G +G V + ++ +A+K + + +++ L + Sbjct: 382 TRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQE 441 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 ++MR D P V G + E VWI MEL + + QV + ++ L A Sbjct: 442 A-LTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQV--RKFSLDLASLILYA 497 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP- 218 + AL +L SK +HRD+ NVL++A VK+ DFG+S Y+ DS G P Sbjct: 498 YQLSTALAYLESK-RFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPI 556 Query: 219 -YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSP 276 +MAPE I N + ++ SD+W G+ M E+ + P+ G + +E Sbjct: 557 KWMAPESI----NFRRFTSASDVWMFGVCMWEILMHGVKPFQ--GVKNNDVIGRIENGER 610 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 ++C + RP + EL L E K Sbjct: 611 LPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEK 654 >2W4O-A nrPDB Length = 349 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 123/280 (43%), Gaps = 17/280 (6%) Query: 41 IGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 I N + +D E ELGRGA +V + + + + A+K ++ TV ++K + ++ Sbjct: 43 IDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEI 99 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + +R + P + ++ + +EL+ + + ++++KG E Sbjct: 100 GVLLR-LSHPNIIKLKEIFETPTEISLVLELVTGG--ELFDRIVEKG-YYSERDAADAVK 155 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCK 217 I++A+ +LH ++HRD+KP N+L +K+ DFG+S + V G Sbjct: 156 QILEAVAYLHEN-GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTP 214 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 Y APE + Y + D+WS+GI L P+ ++++ Sbjct: 215 GYCAPEILRGC----AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYF 270 Query: 278 LPA--DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + D+ S D + + + K+R T + +QHP+ T Sbjct: 271 ISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >3Q5I-A nrPDB Length = 504 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 119/285 (41%), Gaps = 30/285 (10%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ------------KRLLM 98 + + +LG GAYG V + A+K I+ + + + + + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 ++ ++++D P + + + ++ E + + ++Q+I++ + E I Sbjct: 96 EIS-LLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG--ELFEQIINRHK-FDECDAANI 151 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAG 215 I+ + +LH K +++HRD+KP N+L+ N+L +K+ DFG+S + G Sbjct: 152 MKQILSGICYLH-KHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLG 210 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 Y+APE + K Y+ K D+WS G+ M L P+ G Q + + VE+ Sbjct: 211 TAYYIAPEVLK-----KKYNEKCDVWSCGVIMYILLCGYPPF--GGQNDQDIIKKVEKGK 263 Query: 276 PQL---PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 S E + L + +R T E + + + Sbjct: 264 YYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >2YCR-A nrPDB Length = 323 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 64/283 (22%), Positives = 120/283 (42%), Gaps = 19/283 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-------NSQEQKRLLMDLDI 102 D+ LG GA G V+ + + +A+K I + + +++I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 ++ ++ P + F D +I +ELM+ + + +V+ + + E + Sbjct: 69 -LKKLNHPCIIKIKN-FFDAEDYYIVLELMEGG--ELFDKVV-GNKRLKEATCKLYFYQM 123 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 + A+++LH +IHRD+KP NVL++ +K+ DFG S L ++ G Y Sbjct: 124 LLAVQYLHEN-GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 182 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +APE + + GY+ D WSLG+ + P+ T Q+ +P Sbjct: 183 LAPEVL-VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 241 Query: 280 --ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 + S + +D + L + K R T E ++HP+ + K Sbjct: 242 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMK 284 >4P5Q-A nrPDB Length = 361 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 114/271 (42%), Gaps = 18/271 (6%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDIS 103 E+ A ++ +G G +G V R + +A+K ++ ++++ L + I Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASI- 87 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M D P + G + + V I E M+ + + D L + I Sbjct: 88 MGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDA--QFTVIQLVGMLRGIA 145 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKP--Y 219 +++L S + +HRD+ N+LIN+ K+ DFG+S L D A T G P + Sbjct: 146 SGMKYL-SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 204 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 +PE I + ++ SD+WS GI + E ++ PY W Q + + V+E Sbjct: 205 TSPEAIA----YRKFTSASDVWSYGIVLWEVMSYGERPY--WEMSNQDVIKAVDEGYRLP 258 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 P A C +K+ RP + +++ Sbjct: 259 PPMDCPAALYQLMLDCWQKDRNNRPKFEQIV 289 >4KS7-A nrPDB Length = 292 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 79/259 (30%), Positives = 134/259 (51%), Gaps = 14/259 (5%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 ++G G+ G+V R SG+ +AVK + + Q+++ LL + + MR V Y Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + ++W+ ME + + + E+ + + ++++AL +LH++ VIH Sbjct: 88 SYLVGEELWVLMEFLQGGALTDIVSQVR----LNEEQIATVCEAVLQALAYLHAQ-GVIH 142 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSV 236 RD+K ++L+ G+VK+ DFG + V K G +MAPE I+ L Y+ Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL----YAT 198 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCL 295 + DIWSLGI +IE+ PY S +P Q +K++ + P P+L + K S DF + L Sbjct: 199 EVDIWSLGIMVIEMVDGEPPYFS-DSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERML 257 Query: 296 KKNSKERPTYPELMQHPFF 314 ++ +ER T EL+ HPF Sbjct: 258 VRDPQERATAQELLDHPFL 276 >2Z7Q-A nrPDB Length = 321 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 142/304 (46%), Gaps = 24/304 (7%) Query: 22 QPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHV---PSGQI 78 QP +++ + G++ + E + LG+G++G V +R V SG + Sbjct: 1 QPSKDEGVLKEISITHHVKAGSE--KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHL 58 Query: 79 MAVKRIRA-TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLD 137 A+K ++ T+ +++ R M+ DI + V+ PF V + A EG +++ ++ + Sbjct: 59 YAMKVLKKATLKVRDRVRTKMERDI-LADVNHPFVVKLHYAFQTEGKLYLILDFLRGG-- 115 Query: 138 KFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 + + + K E+ + + L+HLHS L +I+RD+KP N+L++ G +K+ D Sbjct: 116 DLFTR-LSKEVMFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTD 173 Query: 198 FGISGYLVDSVAK-TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP 256 FG+S +D K G YMAPE + N++G+S +D WS G+ M E+ P Sbjct: 174 FGLSKEAIDHEKKAYSFCGTVEYMAPEVV----NRQGHSHSADWWSYGVLMFEMLTGSLP 229 Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQH 311 + G ++ ++ + +P S E K+N R E+ +H Sbjct: 230 FQ--GKDRKETMTLILKAKLGMP-QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRH 286 Query: 312 PFFT 315 F++ Sbjct: 287 VFYS 290 >4CZT-A nrPDB Length = 464 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 66/268 (24%), Positives = 125/268 (46%), Gaps = 16/268 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS-MRTVDCPF 111 E LG G + V+ R+V +G +A+K I + + + +IS M+ + P Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 72 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + + + + ++ +E + + + ++ G+ + ED K ++ A+++ HS Sbjct: 73 VIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGR-LKEDEARKYFQQLINAVDYCHS 129 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDSVAKTIDAGCKPYMAPERINPE 228 + V HRD+KP N+L++A G +K+ DFG+S + + G Y+APE I Sbjct: 130 R-GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI--- 185 Query: 229 LNQKGYS-VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 N KGY K+D+WS G+ + L P++ + L + + + P FSA Sbjct: 186 -NNKGYDGAKADLWSCGVILFVLMAGYLPFED--SNLTSLYKKIFKAEFTCPP-WFSASA 241 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFT 315 + L N R T+ E++++ +F Sbjct: 242 KKLIKRILDPNPATRITFAEVIENEWFK 269 >4D28-A nrPDB Length = 446 Score = 243 bits (621), Expect = 6e-65, Method: Composition-based stats. Identities = 69/265 (26%), Positives = 121/265 (45%), Gaps = 14/265 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVDCP 110 E +G G + V+ R+ +G +A+K + + + + ++ ++ I M+ V P Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI-MKIVRHP 69 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V Y L + ++I +E + + + +++ KG+ + ED K +V A+ H H Sbjct: 70 NIVRLYEVLASKSKIYIVLEFVTGG--ELFDRIVHKGR-LKEDESRKYFQQLVDAVAHCH 126 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPEL 229 SK V HRD+KP N+L++ G +K+ DFG+S + V D G Y+APE ++ Sbjct: 127 SK-GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLS--- 182 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 Q +DIWS G+ + + P+ P L + + P FSAE Sbjct: 183 GQGYDGSAADIWSCGVILFVILAGYLPFSETDLPG--LYRKINAAEFDCPP-WFSAEVKF 239 Query: 290 FTSQCLKKNSKERPTYPELMQHPFF 314 + L N K R + + P+F Sbjct: 240 LIHRILDPNPKTRIQIQGIKKDPWF 264 >2Y7J-A nrPDB Length = 365 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 125/276 (45%), Gaps = 18/276 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN-------SQEQKRLLMDLDIS 103 +P +GRG VV + H +G AVK + T + ++ + I Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + P +T + +++ +LM + + + +K + E I S++ Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKG--ELFDYLTEK-VALSEKETRSIMRSLL 210 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 +A+ LH+ +++HRD+KP N+L++ Q+++ DFG S +L G Y+APE Sbjct: 211 EAVSFLHAN-NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPE 269 Query: 224 RINPELNQK--GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 + +++ GY + D+W+ G+ + L P+ W + +++ E Q + Sbjct: 270 ILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPF--WHRRQILMLRMIMEGQYQFSSP 327 Query: 282 KF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 ++ S+ D S+ L+ + + R T + +QHPFF Sbjct: 328 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFF 363 >1AD5-A nrPDB Length = 438 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 80/318 (25%), Positives = 140/318 (44%), Gaps = 37/318 (11%) Query: 7 KKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGV 66 KK N GL + P SS P + + A +E+ + L+ +LG G +G Sbjct: 149 KKGNDGLC---QKLSVPCMSSKPQKPWEKDA--------WEIPRESLKLEKKLGAGQFGE 197 Query: 67 VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVW 126 V + +AVK ++ S E L + ++ M+T+ V + + +E ++ Sbjct: 198 VWMATYNKH-TKVAVKTMKPGSMSVEA--FLAEANV-MKTLQHDKLVKLHAVVTKE-PIY 252 Query: 127 ICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 I E M SL F K D+G P L + I + + + + + IHRD++ +N+ Sbjct: 253 IITEFMAKGSLLDFLKS--DEGSKQPLPKLIDFSAQIAEGMAFIEQR-NYIHRDLRAANI 309 Query: 186 LINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGI 245 L++A K+ DFG++ K + APE I N +++KSD+WS GI Sbjct: 310 LVSASLVCKIADFGLARVGAKFPIK--------WTAPEAI----NFGSFTIKSDVWSFGI 357 Query: 246 TMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 ++E+ R PY P ++ + +E + E + +C K +ERPT Sbjct: 358 LLMEIVTYGRIPYPGMSNP--EVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPT 415 Query: 305 YPEL--MQHPFFTLHESK 320 + + + F+T ES+ Sbjct: 416 FEYIQSVLDDFYTATESQ 433 >4BBM-A nrPDB Length = 331 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 64/329 (19%), Positives = 133/329 (40%), Gaps = 37/329 (11%) Query: 36 KACISIGNQNFEVK-ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK 94 + + +G +N + + E + +G G+YG+V K R+ +G+I+A+K+ + + + K Sbjct: 9 SSGVDLGTENLYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVK 68 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI 154 ++ M ++ + V ++ ++ E +D ++ + + + + Sbjct: 69 KIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG---LDYQV 125 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTID 213 + K I+ + HS ++IHRD+KP N+L++ G VK+CDFG + L + Sbjct: 126 VQKYLFQIINGIGFCHSH-NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDE 184 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ-------- 265 + Y APE + ++ Y D+W++G + E+ + + Q Sbjct: 185 VATRWYRAPELLVGDV---KYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCL 241 Query: 266 --------------------QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 +L ++ E + K S +D +CL + +RP Sbjct: 242 GNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFC 301 Query: 306 PELMQHPFFTLHESKGTDVASFVKLILGD 334 EL+ H FF + + D Sbjct: 302 AELLHHDFFQMDGFAERFSQELQLKVQKD 330 >3Q53-A nrPDB Length = 306 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 82/284 (28%), Positives = 139/284 (48%), Gaps = 21/284 (7%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKR 95 ++ +S+G+ ++G+GA G V V +GQ +A++++ + Q +K Sbjct: 11 RSIVSVGD-----PKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN--LQQQPKKE 63 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDI 154 L+++ + MR P V + + ++W+ ME + SL + + E Sbjct: 64 LIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-----MDEGQ 118 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID- 213 + + ++ALE LHS VIHRD+K N+L+ G VK+ DFG + +K Sbjct: 119 IAAVCRECLQALEFLHSN-QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTM 177 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G +MAPE + +K Y K DIWSLGI IE+ PY + P + L + Sbjct: 178 VGTPYWMAPEVV----TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNE-NPLRALYLIATN 232 Query: 274 PSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 +P+L +K SA F DF ++CL+ + ++R + EL+QH F + Sbjct: 233 GTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLKI 276 >3NIZ-A nrPDB Length = 311 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 128/306 (41%), Gaps = 38/306 (12%) Query: 40 SIGNQNFEVK--ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL 97 S G +N + + + + ++G G YGVV K + G+I+A+KRIR + Sbjct: 8 SSGRENLYFQGLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTA 66 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 + ++ + P V+ + E + + E M+ L K + + + + Sbjct: 67 IREISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTG---LQDSQIKI 123 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGC 216 +++ + H H ++HRD+KP N+LIN+ G +K+ DFG++ + + T + Sbjct: 124 YLYQLLRGVAHCHQH-RILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVT 182 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ--QLKQVVEEP 274 Y AP+ + + K YS DIWS+G E+ + + Q ++ ++ P Sbjct: 183 LWYRAPDVL---MGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTP 239 Query: 275 SPQ------------------LPADKFSA-------EFVDFTSQCLKKNSKERPTYPELM 309 +P+ +S+ E +D S L + +R + + M Sbjct: 240 NPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAM 299 Query: 310 QHPFFT 315 HP+F Sbjct: 300 NHPYFK 305 >2OGV-A nrPDB Length = 317 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 118/282 (41%), Gaps = 22/282 (7%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-----MAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 30 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 89 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDK------GQTI 150 +L I V GA G V + E L F ++ + G+ + Sbjct: 90 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPL 149 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK 210 L + + + + L SK + IHRDV NVL+ K+ DFG++ +++ Sbjct: 150 ELRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 208 Query: 211 TIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQ 266 + + +MAPE I + Y+V+SD+WS GI + E+ L PY + Sbjct: 209 IVKGNARLPVKWMAPESIFDCV----YTVQSDVWSYGILLWEIFSLGLNPYPGI-LVNSK 263 Query: 267 LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 ++V++ C RPT+ ++ Sbjct: 264 FYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >4NIF-A nrPDB Length = 333 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 122/279 (43%), Gaps = 22/279 (7%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 +D +G G+Y ++ H + AVK I + + +++I +R Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-----EIEILLRYGQH 61 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P +T V++ ELM + +++ + + E + +I K +E+L Sbjct: 62 PNIITLKDVYDDGKHVYLVTELMRGG--ELLDKILRQ-KFFSEREASFVLHTIGKTVEYL 118 Query: 170 HSKLSVIHRDVKPSNVL-INALGQ---VKMCDFGISGYL-VDSVAKTIDAGCKPYMAPER 224 HS+ V+HRD+KPSN+L ++ G +++CDFG + L ++ ++APE Sbjct: 119 HSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEV 177 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW-GTPFQQLKQVVEEPSPQLP---A 280 L ++GY DIWSLGI + + P+ + +++ + L Sbjct: 178 ----LKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW 233 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 + S D S+ L + +R T +++QHP+ T + Sbjct: 234 NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK 272 >3UDB-A nrPDB Length = 317 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 60/271 (22%), Positives = 121/271 (44%), Gaps = 15/271 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 +D E + ++G G +GV MR + +++AVK I + + + ++ I+ R++ Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI--ERGEKIDENVKREI-INHRSLR 73 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V F + + I ME + ++++ + G+ ED ++ + + Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGR-FSEDEARFFFQQLISGVSY 130 Query: 169 LHSKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 H+ + V HRD+K N L++ ++K+ DFG S V G Y+APE + Sbjct: 131 AHA-MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVL- 188 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLPAD-KF 283 L ++ +D+WS G+T+ + + +P++ P F++ + +P Sbjct: 189 --LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHI 246 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E S+ + +R + PE+ H +F Sbjct: 247 SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >3I6U-A nrPDB Length = 419 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 120/283 (42%), Gaps = 19/283 (6%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-------NSQEQKRLLMDLDI 102 D+ LG GA G V+ + + +A++ I + + +++I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 ++ ++ P + F D +I +ELM+ + + +V+ + + E + Sbjct: 194 -LKKLNHPCIIKIKN-FFDAEDYYIVLELMEGG--ELFDKVV-GNKRLKEATCKLYFYQM 248 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 + A+++LH +IHRD+KP NVL++ +K+ DFG S L ++ G Y Sbjct: 249 LLAVQYLHEN-GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 307 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 +APE + + GY+ D WSLG+ + P+ T Q+ +P Sbjct: 308 LAPEVL-VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 366 Query: 280 --ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 + S + +D + L + K R T E ++HP+ + K Sbjct: 367 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMK 409 >2J90-A nrPDB Length = 304 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 132/295 (44%), Gaps = 26/295 (8%) Query: 36 KACISIGNQNFEVKA---DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE 92 + + +G +N ++ D E ELG G + +V K R +G+ A K I+ S Sbjct: 8 SSGVDLGTENLYFQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSS 67 Query: 93 QK-----RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKG 147 ++ + +++I +R + P +T + + DV + +EL+ + + + +K Sbjct: 68 RRGVSREEIEREVNI-LREIRHPNIITLHDIFENKTDVVLILELVSGG--ELFDFLAEK- 123 Query: 148 QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA----LGQVKMCDFGISGY 203 +++ ED + I+ + +LHSK + H D+KP N+++ ++K+ DFGI+ Sbjct: 124 ESLTEDEATQFLKQILDGVHYLHSK-RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK 182 Query: 204 LVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 263 + G ++APE + N + +++D+WS+G+ L P+ G Sbjct: 183 IEAGNEFKNIFGTPEFVAPEIV----NYEPLGLEADMWSIGVITYILLSGASPF--LGET 236 Query: 264 FQQLKQVVEEPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 Q+ + + + F S DF + L K+ K R T + ++H + Sbjct: 237 KQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >4E93-A nrPDB Length = 377 Score = 241 bits (616), Expect = 2e-64, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 19/308 (6%) Query: 9 RNPGLKIPKEAFEQPQTSSTPPRDLDSKACI---SIGNQNFEVKADDLEPIMELGRGAYG 65 R G P ST + ++ + + +DL ++GRG +G Sbjct: 69 RLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFG 128 Query: 66 VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV 125 V R ++AVK R T+ + + L + I ++ P V G ++ + Sbjct: 129 EVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARI-LKQYSHPNIVRLIGVCTQKQPI 187 Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 +I MEL+ F + +G + L ++ +E+L SK IHRD+ N Sbjct: 188 YIVMELVQGG--DFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKC-CIHRDLAARNC 244 Query: 186 LINALGQVKMCDFGISGYLVDSVAKTIDAGCKP----YMAPERINPELNQKGYSVKSDIW 241 L+ +K+ DFG+S D V G + + APE LN YS +SD+W Sbjct: 245 LVTEKNVLKISDFGMSREEADGV-YAASGGLRQVPVKWTAPE----ALNYGRYSSESDVW 299 Query: 242 SLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 S GI + E ++ PY + QQ ++ VE+ + QC Sbjct: 300 SFGILLWETFSLGASPYPNLSN--QQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPG 357 Query: 301 ERPTYPEL 308 +RP++ + Sbjct: 358 QRPSFSTI 365 >2PSQ-A nrPDB Length = 370 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 121/293 (41%), Gaps = 31/293 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKM------RHVP-SGQIMAVKRIRATVNSQEQKR 95 + +E D L LG G +G V + P +AVK ++ ++ Sbjct: 73 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD 132 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDI 154 L+ ++++ + GA ++G +++ +E +L ++ + G DI Sbjct: 133 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI 192 Query: 155 ------------LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 L + + +E+L S+ IHRD+ NVL+ +K+ DFG++ Sbjct: 193 NRVPEEQMTFKDLVSCTYQLARGMEYLASQ-KCIHRDLAARNVLVTENNVMKIADFGLAR 251 Query: 203 YLVD-SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 + + K G P +MAPE L + Y+ +SD+WS G+ M E+ PY Sbjct: 252 DINNIDYYKKTTNGRLPVKWMAPE----ALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 307 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 308 --GIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >5MJB-A nrPDB Length = 305 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 117/274 (42%), Gaps = 20/274 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDIS 103 E+ ++ +G G +G V K R G+ +A+K ++A + ++++ L + I Sbjct: 22 EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASI- 80 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M D + G + + V I E M+ + + D L + I Sbjct: 81 MGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDG--QFTVIQLVGMLRGIA 138 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV---AKTIDAGCK--- 217 +++L S+++ +HRD+ N+L+N+ K+ DFG+S YL D T G K Sbjct: 139 AGMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPV 197 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSP 276 + APE I + ++ SD+WS GI M E ++ PY W Q + +E+ Sbjct: 198 RWTAPEAIA----YRKFTSASDVWSYGIVMWEVMSFGERPY--WDMSNQDVINAIEQDYR 251 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P A C +K+ RP + E++ Sbjct: 252 LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVN 285 >3BEA-A nrPDB Length = 333 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 26/286 (9%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-----MAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 97 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVID----------K 146 +L I V GA G V + E L F ++ Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIA 157 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 T+ L + + + + L SK + IHRDV NVL+ K+ DFG++ +++ Sbjct: 158 NSTLSTRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN 216 Query: 207 SVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGT 262 + + +MAPE I + Y+V+SD+WS GI + E+ L PY Sbjct: 217 DSNYIVKGNARLPVKWMAPESIFDCV----YTVQSDVWSYGILLWEIFSLGLNPYPGI-L 271 Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + ++V++ C RPT+ ++ Sbjct: 272 VNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >6E9W-A nrPDB Length = 443 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 129/302 (42%), Gaps = 17/302 (5%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDI 102 ++ +KA+D E + +GRGA+G V+ +RH + ++ A+K + + + + + Sbjct: 95 RDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERD 154 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 M + P+ V + A + +++ ME M D +PE + Sbjct: 155 IMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD----VPEKWARFYTAEV 210 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCKPYM 220 V AL+ +HS + IHRDVKP N+L++ G +K+ DFG + D G Y+ Sbjct: 211 VLALDAIHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYI 269 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 +PE + + Y + D WS+G+ + E+ + P+ + K + + S P Sbjct: 270 SPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPD 329 Query: 281 DK-FSAEFVDFTSQCLKKNSKERP---TYPELMQHPFF----TLHESKGTDVASFVKLIL 332 D S E + L + + R E+ +H FF E+ VA V + Sbjct: 330 DNDISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS 388 Query: 333 GD 334 D Sbjct: 389 SD 390 >4APC-A nrPDB Length = 350 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 128/287 (44%), Gaps = 10/287 (3%) Query: 36 KACISIGNQNFEVK-ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK 94 + + +G +N + + + ++G G++G ++ G+ +K I + S +++ Sbjct: 8 SSGVDLGTENLYFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKER 67 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI 154 + + P V + + G ++I M+ + D F + KG ED Sbjct: 68 EESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGG-DLFKRINAQKGVLFQEDQ 126 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA 214 + V I AL+H+H + ++HRD+K N+ + G V++ DFGI+ L +V Sbjct: 127 ILDWFVQICLALKHVHDR-KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARAC 185 Query: 215 -GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G Y++PE K Y+ KSDIW+LG + EL L+ +++ LK + Sbjct: 186 IGTPYYLSPEI----CENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS 241 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 P + +S + SQ K+N ++RP+ +++ F K Sbjct: 242 FPPV--SLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEK 286 >5JZN-A nrPDB Length = 280 Score = 240 bits (612), Expect = 7e-64, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 128/286 (44%), Gaps = 21/286 (7%) Query: 40 SIGNQNFEVKA---DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 + + F++ A + + +G G + VV++ + + A+K I+ + ++ + Sbjct: 5 EVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMI 64 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 ++ I +R V P V + ++++ MEL+ + + + E Sbjct: 65 QNEVSI-LRRVKHPNIVLLIEEMDVPTELYLVMELVKGG--DLFDAITSTNKY-TERDAS 120 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTI 212 + ++ A+++LHS L+++HRD+KP N+L+ + +K+ DFG++ +VD T+ Sbjct: 121 GMLYNLASAIKYLHS-LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT-IVDGPLYTV 178 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+APE I + GY +K DIW+ G+ L P+ G + L + Sbjct: 179 -CGTPTYVAPEIIA----ETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQIL 233 Query: 273 EPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P D S + + L + +R + ++++HP+ Sbjct: 234 MGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN 279 >4RGJ-A nrPDB Length = 520 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 120/279 (43%), Gaps = 21/279 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVD 108 + + I LG+G++G V R +G A+K I + +++ LL +++ ++ +D Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVE-LLKMLD 118 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + Y ++ ++ + + ++I + + E +I I+ + + Sbjct: 119 HINIMKLYEFFEDNNYYYLVSDVYTGG--ELFDEIISRKRFY-EIDAARIIKQILSGITY 175 Query: 169 LHSKLSVIHRDVKPSNVLI----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 +H K +V+HRD+KP N+L+ +K+ DFG+S + S G Y+AP+ Sbjct: 176 MH-KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA---D 281 + Y K DIWS G+ + L P++ G+ + + VE Sbjct: 235 L-----HGTYDEKCDIWSCGVILYILLSGCPPFN--GSNEYDILKKVEAGKYTFDLPQFK 287 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 K S + D + L S R + + ++H + + SK Sbjct: 288 KISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSK 326 >6GU6-A nrPDB Length = 302 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 127/299 (42%), Gaps = 34/299 (11%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 +D I ++G G YGVV K RH +GQ++A+K+IR + + ++ + Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V+ L ++ +++ E + L K+ + GQ + ++ I++ + Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIP-PGQYMDSSLVKSYLYQILQGIVFC 124 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPE 228 HS+ V+HRD+KP N+LI+ G +K+ DFG++ + T + Y +PE + Sbjct: 125 HSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL--- 180 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV------------------ 270 L YS DIWS+G ELA + P + QL ++ Sbjct: 181 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 239 Query: 271 --VEEPSPQLPADKFSAEFV-------DFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 + P+ ++ D S+ L + +R + + HP+F +++ Sbjct: 240 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 298 >2H8H-A nrPDB Length = 535 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 130/317 (41%), Gaps = 30/317 (9%) Query: 8 KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67 K GL +S P + +E+ + L ++LG+G +G V Sbjct: 234 KHADGLC---HRLTTVCPTSKPQ-------TQGLAKDAWEIPRESLRLEVKLGQGCFGEV 283 Query: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWI 127 + + +A+K ++ S E L + + M+ + V Y + E ++I Sbjct: 284 WMGTWNGTTR-VAIKTLKPGTMSPEA--FLQEAQV-MKKLRHEKLVQLYAVVSEE-PIYI 338 Query: 128 CMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 E M SL F K + G+ + L +A I + ++ +++ +HRD++ +N+L Sbjct: 339 VTEYMSKGSLLDFLK--GETGKYLRLPQLVDMAAQIASGMAYV-ERMNYVHRDLRAANIL 395 Query: 187 INALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLG 244 + K+ DFG++ + D+ P + APE +++KSD+WS G Sbjct: 396 VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE----AALYGRFTIKSDVWSFG 451 Query: 245 ITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 I + EL R PY G +++ VE + D QC +K +ERP Sbjct: 452 ILLTELTTKGRVPYP--GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 509 Query: 304 TYPELMQ--HPFFTLHE 318 T+ L +FT E Sbjct: 510 TFEYLQAFLEDYFTSTE 526 >3KRL-A nrPDB Length = 335 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 117/288 (40%), Gaps = 28/288 (9%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-----MAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 38 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 97 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKG--------- 147 +L I V GA G V + E L F ++ G Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSH 157 Query: 148 ---QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 + + L + + + + L SK + IHRDV NVL+ K+ DFG++ + Sbjct: 158 NPEEQLSSRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGDFGLARDI 216 Query: 205 VDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSW 260 ++ + + +MAPE I + Y+V+SD+WS GI + E+ L PY Sbjct: 217 MNDSNYIVKGNARLPVKWMAPESIFDCV----YTVQSDVWSYGILLWEIFSLGLNPYPGI 272 Query: 261 GTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + ++V++ C RPT+ ++ Sbjct: 273 -LVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >1FOT-A nrPDB Length = 318 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 126/271 (46%), Gaps = 19/271 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ-EQKRLLMDLDISMRTVDC 109 D + + LG G++G V +R +G+ A+K ++ + + +Q D + + V Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 PF + +G +++ M+ ++ + + ++ K Q P + A + ALE+L Sbjct: 66 PFIIRMWGTFQDAQQIFMIMDYIEGG--ELFS-LLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 HSK +I+RD+KP N+L++ G +K+ DFG + Y+ D G Y+APE ++ Sbjct: 123 HSK-DIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAPEVVST-- 177 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 K Y+ D WS GI + E+ P+ T + + + + P F+ + D Sbjct: 178 --KPYNKSIDWWSFGILIYEMLAGYTPFYDSNT--MKTYEKILNAELRFPP-FFNEDVKD 232 Query: 290 FTSQCLKKNSKERP-----TYPELMQHPFFT 315 S+ + ++ +R ++ HP+F Sbjct: 233 LLSRLITRDLSQRLGNLQNGTEDVKNHPWFK 263 >4I6B-A nrPDB Length = 308 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 127/267 (47%), Gaps = 13/267 (4%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM-RTVDC 109 LG+G + +M + + ++ A K I + S+ +R +D +I + R + Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V FY + +++I +E + ++ + + E + IV L++L Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCS---RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYL 144 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD-SVAKTIDAGCKPYMAPERINPE 228 H + ++HRD+K N IN ++K+ DFG++ L + G Y++PE Sbjct: 145 HEQE-ILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEV---- 199 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 LN++G+ +SDIW+LG M + + R P+++ T ++ + + E +P+ + Sbjct: 200 LNKQGHGAESDIWALGCVMYTMLLGRPPFET--TNLKETYRSIREARYTMPSSLLAP-AK 256 Query: 289 DFTSQCLKKNSKERPTYPELMQHPFFT 315 + L KN ++RP+ ++++H FFT Sbjct: 257 HLIASMLSKNPEDRPSLDDIIRHDFFT 283 >4K33-A nrPDB Length = 325 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 123/307 (40%), Gaps = 31/307 (10%) Query: 29 PPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ-------IMAV 81 PP + + +E+ L LG GA+G V + + +AV Sbjct: 14 PPTLANVSELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAV 73 Query: 82 KRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM--------- 132 K ++ ++ L+ ++++ + GA + G +++ +E Sbjct: 74 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 133 Query: 133 ----DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN 188 LD + + + L A + + +E+L S+ IHRD+ NVL+ Sbjct: 134 RARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQ-KCIHRDLAARNVLVT 192 Query: 189 ALGQVKMCDFGISGYLVD-SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGI 245 +K+ DFG++ + + K G P +MAPE L + Y+ +SD+WS G+ Sbjct: 193 EDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPE----ALFDRVYTHQSDVWSFGV 248 Query: 246 TMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 + E+ PY G P ++L ++++E + + +C +RPT Sbjct: 249 LLWEIFTLGGSPYP--GIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 306 Query: 305 YPELMQH 311 + +L++ Sbjct: 307 FKQLVED 313 >6F3F-A nrPDB Length = 455 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 72/317 (22%), Positives = 131/317 (41%), Gaps = 30/317 (9%) Query: 8 KRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67 K GL +S P + +E+ + L ++LG+G +G V Sbjct: 154 KHADGLC---HRLTTVCPTSKPQ-------TQGLAKDAWEIPRESLRLEVKLGQGCFGEV 203 Query: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWI 127 + + +A+K ++ S E L + + M+ + V Y + E ++I Sbjct: 204 WMGTWNGTTR-VAIKTLKPGTMSPEA--FLQEAQV-MKKLRHEKLVQLYAVVSEE-PIYI 258 Query: 128 CMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 E M+ SL F K + G+ + L ++ I + ++ +++ +HRD++ +N+L Sbjct: 259 VTEYMNKGSLLDFLK--GETGKYLRLPQLVDMSAQIASGMAYV-ERMNYVHRDLRAANIL 315 Query: 187 INALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLG 244 + K+ DFG++ + D+ P + APE +++KSD+WS G Sbjct: 316 VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE----AALYGRFTIKSDVWSFG 371 Query: 245 ITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 I + EL R PY G +++ VE + D QC +K +ERP Sbjct: 372 ILLTELTTKGRVPYP--GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 429 Query: 304 TYPELMQ--HPFFTLHE 318 T+ L +FT E Sbjct: 430 TFEYLQAFLEDYFTSTE 446 >3F3Z-A nrPDB Length = 277 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 117/275 (42%), Gaps = 19/275 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 +GRG++G V+ + A K+I ++ R +++I M+++D P Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKI-PKYFVEDVDRFKQEIEI-MKSLDHPNI 68 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 + Y D+++ MEL + +++V+ K + E +I ++ A+ + H K Sbjct: 69 IRLYETFEDNTDIYLVMELCTGG--ELFERVVHK-RVFRESDAARIMKDVLSAVAYCH-K 124 Query: 173 LSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL 229 L+V HRD+KP N L + +K+ DFG++ G Y++P+ + Sbjct: 125 LNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEGL- 183 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF---SAE 286 Y + D WS G+ M L P+ + ++ + E + P + S + Sbjct: 184 ----YGPECDEWSAGVMMYVLLCGYPPFSAPTDS--EVMLKIREGTFTFPEKDWLNVSPQ 237 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 + L K+ K+R T + ++H +F S Sbjct: 238 AESLIRRLLTKSPKQRITSLQALEHEWFEKQLSSS 272 >5EG3-A nrPDB Length = 334 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 122/293 (41%), Gaps = 31/293 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKM------RHVP-SGQIMAVKRIRATVNSQEQKR 95 + +E D L LG GA+G V + P +AVK ++ ++ Sbjct: 27 DPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD 86 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDI 154 L+ ++++ + GA ++G +++ + +L ++ + G + DI Sbjct: 87 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDI 146 Query: 155 ------------LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 L + + +E+L S+ IHRD+ NVL+ +K+ DFG++ Sbjct: 147 NRVPEEQMTFKDLVSCTYQLARGMEYLASQ-KCIHRDLAARNVLVTENNVMKIADFGLAR 205 Query: 203 YLVD-SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 + + K G P +MAPE L + Y+ +SD+WS G+ M E+ PY Sbjct: 206 DINNIDFFKETTNGRLPVKWMAPE----ALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 261 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 G P ++L ++++E + E C +RPT+ +L++ Sbjct: 262 --GIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4R7H-A nrPDB Length = 343 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 118/295 (40%), Gaps = 35/295 (11%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-----MAVKRIRATVNSQEQKRLL 97 N+ +E ++L+ LG GA+G V + G+ +AVK +++T ++ E++ L+ Sbjct: 42 NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALM 101 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDK---------- 146 +L I V GA G V + E L F ++ + Sbjct: 102 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQ 161 Query: 147 ---------GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 G+ + L + + + + L SK + IHRDV NVL+ K+ D Sbjct: 162 DPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASK-NCIHRDVAARNVLLTNGHVAKIGD 220 Query: 198 FGISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 254 FG++ +++ + + +MAPE I + Y+V+SD+WS GI + E+ L Sbjct: 221 FGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSV----YTVQSDVWSYGILLWEIFSLG 276 Query: 255 F-PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 PY + ++V++ C RPT+ ++ Sbjct: 277 LNPYPGI-LVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >4JXF-A nrPDB Length = 266 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 124/273 (45%), Gaps = 14/273 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE--QKRLLMDLDISMRT 106 K +D + LG+G++ V + + +G +A+K I + +R+ ++ I Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHC-Q 63 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P + Y V++ +E+ + + + ++ + E+ I+ + Sbjct: 64 LKHPSILELYNYFEDSNYVYLVLEMCHNG--EMNRYLKNRVKPFSENEARHFMHQIITGM 121 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERI 225 +LHS ++HRD+ SN+L+ +K+ DFG++ L + G Y++PE Sbjct: 122 LYLHSH-GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEI- 179 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 + + ++SD+WSLG L I R P+D+ T L +VV ++P+ S Sbjct: 180 ---ATRSAHGLESDVWSLGCMFYTLLIGRPPFDT-DTVKNTLNKVVL-ADYEMPS-FLSI 233 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 E D Q L++N +R + ++ HPF + + Sbjct: 234 EAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 266 >6FDY-U nrPDB Length = 276 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 125/276 (45%), Gaps = 17/276 (6%) Query: 49 KADDLEPIMELGRGAYGVVEKMR-HVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRT 106 + D LG G Y V K + +++A+K + + ++N + LL +++I ++ Sbjct: 9 RLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI-LKG 67 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P V + ++++ ME + I + +PE + + AL Sbjct: 68 IRHPHIVQLKDFQWDSDNIYLIMEFCAGGD---LSRFIHTRRILPEKVARVFMQQLASAL 124 Query: 167 EHLHSKLSVIHRDVKPSNVLIN--ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 + LH + ++ H D+KP N+L++ +K+ DFG + ++ K + G YMAPE Sbjct: 125 QFLHER-NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEM 183 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP-QLP-ADK 282 + Q+ Y + D+WS+G+ + E + P+ S F +L++ + +LP Sbjct: 184 VC----QRQYDARVDLWSMGVILYEALFGQPPFASRS--FSELEEKIRSNRVIELPLRPL 237 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 S + D + L+++ R ++ + HP+ L Sbjct: 238 LSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEH 273 >4PDS-A nrPDB Length = 347 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 117/281 (41%), Gaps = 20/281 (7%) Query: 50 ADDLEPI-MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 D I +G+GA+ V+K +G+ +VK I + +L++ ++ ++ Sbjct: 29 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEV-LQKLN 87 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V G ++ ME + V G + ED +I+ I+ A+++ Sbjct: 88 HPRIVRLKGFYEDTESYYMVMEFVSGG--DLMDFVAAHG-AVGEDAGREISRQILTAIKY 144 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 +HS + + HRD+KP N+LI VK+ FG++ + G Y+APE I Sbjct: 145 IHS-MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIR 203 Query: 227 PE---------LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + + YS D+WS+G + + P+ S T Q KQ+ + Sbjct: 204 GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF-SGSTQDQLYKQIGRGSYHE 262 Query: 278 LPADKF--SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 P F S E DF L+ + R T + + HP+ + Sbjct: 263 GPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKM 303 >5AMN-A nrPDB Length = 299 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 132/295 (44%), Gaps = 24/295 (8%) Query: 30 PRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKM-----RHVPSGQIMAVKRI 84 P L A + + +E +L LG G +G V K + +AVK + Sbjct: 2 PLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKML 61 Query: 85 RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQV 143 + + E + LL + ++ ++ V+ P + YGA ++G + + +E SL F ++ Sbjct: 62 KENASPSELRDLLSEFNV-LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES 120 Query: 144 IDKGQTIPEDILG------KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 G P++ A I + +++L +++ ++HRD+ N+L+ ++K+ D Sbjct: 121 RKVGPGYPDERALTMGDLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISD 179 Query: 198 FGISGYLVDSVAK-TIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-L 253 FG+S + + + G P +MA E + + Y+ +SD+WS G+ + E+ Sbjct: 180 FGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHI----YTTQSDVWSFGVLLWEIVTLG 235 Query: 254 RFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 PY G P ++L +++ D S E QC K+ +RP + ++ Sbjct: 236 GNPYP--GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 288 >3CJF-A nrPDB Length = 309 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 64/287 (22%), Positives = 120/287 (41%), Gaps = 25/287 (8%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLLM 98 +E D L LGRGA+G V + + + +AVK ++ E + L+ Sbjct: 20 SKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMS 79 Query: 99 DLDISMRTVDCPFTVTFYGALFREG-DVWICMELMD-TSLDKFYKQVIDKGQT------- 149 +L I + V GA + G + + +E +L + + ++ Sbjct: 80 ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKD 139 Query: 150 -IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + + L + + K +E L S+ IHRD+ N+L++ VK+CDFG++ + Sbjct: 140 FLTLEHLICYSFQVAKGMEFLASR-KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 198 Query: 209 AKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPF 264 + +MAPE I + Y+++SD+WS G+ + E+ PY Sbjct: 199 DYVRKGDARLPLKWMAPETI----FDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID- 253 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 ++ + ++E + D + E C +RPT+ EL++H Sbjct: 254 EEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >4CQG-A nrPDB Length = 331 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 122/281 (43%), Gaps = 13/281 (4%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 E +G G + V+ HV +G+++A+K + + R+ ++D +++++ Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEID-ALKSLRHQHI 69 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 Y L + +++ +E + + +I + + + E+ + I+ A+ ++HS+ Sbjct: 70 CQLYHVLETKNKIFMVLEYCPGG--ELFDYIISQDR-LSEEETRVVFRQILSAVAYVHSQ 126 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCKPYMAPERINPELN 230 HRD+KP N+L + ++K+ DFG+ + + G Y APE I Sbjct: 127 -GYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQ---G 182 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + ++D+WS+GI + L P+D L + + ++P S + Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDD--DNVMALYKKIMRGKYEVP-KWLSPSSILL 239 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 Q L+ + K+R + L+ HP+ S + S L Sbjct: 240 LQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLT 280 >4JG6-A nrPDB Length = 355 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 122/277 (44%), Gaps = 22/277 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D E ++G G+Y V ++ H + AVK I + + +++I +R P Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-----EIEILLRYGQHP 89 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 +T V++ ELM + +++ + + E + +I K +E+LH Sbjct: 90 NIITLKDVYDDGKYVYVVTELMKGG--ELLDKILRQ-KFFSEREASAVLFTITKTVEYLH 146 Query: 171 SKLSVIHRDVKPSNVL-INALGQ---VKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERI 225 ++ V+HRD+KPSN+L ++ G +++CDFG + L ++ ++APE + Sbjct: 147 AQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF-QQLKQVVEEPSPQLP---AD 281 ++GY DIWSLG+ + + P+ + +++ + L + Sbjct: 206 E----RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 261 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 S D S+ L + +R T +++HP+ + Sbjct: 262 SVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWD 298 >1U5R-A nrPDB Length = 348 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 77/278 (27%), Positives = 136/278 (48%), Gaps = 13/278 (4%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK--RLLMDLDISMRTVDCP 110 + E+G G++G V R V + +++A+K++ + +K ++ ++ ++ + P Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVR-FLQKLRHP 114 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 T+ + G RE W+ ME S + + + E + + ++ L +LH Sbjct: 115 NTIQYRGCYLREHTAWLVMEYCLGSASDLLEV---HKKPLQEVEIAAVTHGALQGLAYLH 171 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 S ++IHRDVK N+L++ G VK+ DFG + + + G +MAPE I ++ Sbjct: 172 SH-NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVI-LAMD 226 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + Y K D+WSLGIT IELA + P + L + + SP L + +S F +F Sbjct: 227 EGQYDGKVDVWSLGITCIELAERKPPLFNM-NAMSALYHIAQNESPALQSGHWSEYFRNF 285 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 CL+K ++RPT L++H F L E T + + Sbjct: 286 VDSCLQKIPQDRPTSEVLLKHRFV-LRERPPTVIMDLI 322 >5F9E-A nrPDB Length = 353 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 63/273 (23%), Positives = 121/273 (44%), Gaps = 15/273 (5%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV--NSQEQKRLLMDLDIS 103 ++K +D E LG+G++G V + Q A+K ++ V + + +++ + Sbjct: 14 IKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVL 73 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + PF + + +++ ME ++ ++ Q K A I+ Sbjct: 74 SLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK---FDLSRATFYAAEII 130 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAP 222 L+ LHSK +++RD+K N+L++ G +K+ DFG+ + AKT + G Y+AP Sbjct: 131 LGLQFLHSK-GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAP 189 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E L + Y+ D WS G+ + E+ I + P+ G ++L + +P P Sbjct: 190 EI----LLGQKYNHSVDWWSFGVLLYEMLIGQSPF--HGQDEEELFHSIRMDNPFYPR-W 242 Query: 283 FSAEFVDFTSQCLKKNSKERPTYP-ELMQHPFF 314 E D + + ++R ++ QHP F Sbjct: 243 LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLF 275 >5VO2-A nrPDB Length = 300 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 79/293 (26%), Positives = 125/293 (42%), Gaps = 25/293 (8%) Query: 41 IGNQN-FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 +G+++ +EV +++ + +G GA G V R G+ +AVK++R L + Sbjct: 1 MGSEDLWEVPFEEILDLQWVGSGAQGAVFLGR--FHGEEVAVKKVRD----------LKE 48 Query: 100 LDI-SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 DI +R + P +TF G + I ME +V+ G+ + +L Sbjct: 49 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQ---LYEVLRAGRPVTPSLLVDW 105 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 ++ I + +LH +IHRD+K N+LI VK+ DFG S L D K AG Sbjct: 106 SMGIAGGMNYLHLH-KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVA 164 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 +MAPE I E S K DIWS G+ + EL PY + + V S L Sbjct: 165 WMAPEVIRNE----PVSEKVDIWSFGVVLWELLTGEIPYKDVDSS--AIIWGVGSNSLHL 218 Query: 279 P-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKL 330 P F QC + RP++ +++ H + T ++ K Sbjct: 219 PVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKS 271 >3DKO-A nrPDB Length = 318 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 122/309 (39%), Gaps = 34/309 (11%) Query: 11 PGLK--IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVE 68 PG K I E +E P + E+ A ++ +G G +G V Sbjct: 15 PGTKTYIDPETYEDPNRAVHQFAK--------------ELDASCIKIERVIGAGEFGEVC 60 Query: 69 KMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV 125 R G+ +A+K ++ ++++ L + I M D P V G + R V Sbjct: 61 SGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASI-MGQFDHPNVVHLEGVVTRGKPV 119 Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 I +E M+ + + D L + I + +L + + +HRD+ N+ Sbjct: 120 MIVIEFMENGALDAFLRKHDG--QFTVIQLVGMLRGIAAGMRYL-ADMGYVHRDLAARNI 176 Query: 186 LINALGQVKMCDFGISGYLVDSVA--KTIDAGCKP--YMAPERINPELNQKGYSVKSDIW 241 L+N+ K+ DFG+S + D T G P + APE I + ++ SD+W Sbjct: 177 LVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAI----QYRKFTSASDVW 232 Query: 242 SLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK 300 S GI M E ++ PY W Q + + +EE A C +K Sbjct: 233 SYGIVMWEVMSYGERPY--WDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERA 290 Query: 301 ERPTYPELM 309 ERP + +++ Sbjct: 291 ERPKFEQIV 299 >3G0E-A nrPDB Length = 336 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 118/292 (40%), Gaps = 30/292 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLL 97 + +E + L LG GA+G V + + +AVK ++ + + E++ L+ Sbjct: 38 DHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALM 97 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKG--------- 147 +L + + V GA G + E L F ++ D Sbjct: 98 SELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAI 157 Query: 148 -----QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + L + + K + L SK + IHRD+ N+L+ K+CDFG++ Sbjct: 158 MEDDELALDLEDLLSFSYQVAKGMAFLASK-NCIHRDLAARNILLTHGRITKICDFGLAR 216 Query: 203 YLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 + + + + +MAPE I + Y+ +SD+WS GI + EL PY Sbjct: 217 DIKNDSNYVVKGNARLPVKWMAPESIFNCV----YTFESDVWSYGIFLWELFSLGSSPYP 272 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + ++++E L + AE D C + +RPT+ +++Q Sbjct: 273 GMPVD-SKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >2YAB-A nrPDB Length = 361 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 64/282 (22%), Positives = 127/282 (45%), Gaps = 23/282 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-----RLLMDLDISMR 105 D + ELG G + +V+K R +G A K I+ + ++ + ++ I +R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSI-LR 70 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 V P +T + DV + +EL+ + + + K +++ E+ I+ Sbjct: 71 QVLHPNIITLHDVYENRTDVVLILELVSGG--ELFDFLAQK-ESLSEEEATSFIKQILDG 127 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALG----QVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 + +LH+K + H D+KP N+++ +K+ DFG++ + D V G ++A Sbjct: 128 VNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 PE + N + +++D+WS+G+ L P+ G Q+ + S + Sbjct: 187 PEIV----NYEPLGLEADMWSIGVITYILLSGASPF--LGDTKQETLANITAVSYDFDEE 240 Query: 282 KFSAE---FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 FS DF + L K +++R T E ++HP+ T +++ Sbjct: 241 FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQ 282 >2PL0-A nrPDB Length = 289 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 126/282 (44%), Gaps = 20/282 (7%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 +EV + L+ + LG G +G V + +AVK ++ S + L + + M Sbjct: 17 EWEVPRETLKLVERLGAGQFGEVWMGYYNGH-TKVAVKSLKQGSMSPDA--FLAEAN-LM 72 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + + V Y + +E ++I E M+ SL F K G + + L +A I Sbjct: 73 KQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLK--TPSGIKLTINKLLDMAAQIA 129 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMA 221 + + + + + IHRD++ +N+L++ K+ DFG++ + D+ + P + A Sbjct: 130 EGMAFIEER-NYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTA 188 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 PE I N +++KSD+WS GI + E+ R PY P ++ Q +E + Sbjct: 189 PEAI----NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNP--EVIQNLERGYRMVRP 242 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHESK 320 D E C K+ ++RPT+ L FFT E + Sbjct: 243 DNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQ 284 >4AU8-A nrPDB Length = 296 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 70/294 (23%), Positives = 123/294 (41%), Gaps = 35/294 (11%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + E + ++G G YG V K ++ + +I+A+KR+R + + + ++ + Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 64 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V + L + + + E D L K++ + +I+ ++K L Sbjct: 65 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC---NGDLDPEIVKSFLFQLLKGLGFC 121 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPE 228 HS+ +V+HRD+KP N+LIN G++K+ DFG++ + + + Y P+ + Sbjct: 122 HSR-NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--- 177 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE---------------- 272 K YS D+WS G ELA P QLK++ Sbjct: 178 FGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL 237 Query: 273 ---EPSPQLPA--------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +P P PA K +A D LK N +R + E +QHP+F+ Sbjct: 238 PDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 291 >2Y6O-A nrPDB Length = 291 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 70/273 (25%), Positives = 120/273 (43%), Gaps = 20/273 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDIS 103 E+ A ++ +G G +G V R G+ +A+K ++A ++++ L + I Sbjct: 10 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASI- 68 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 M D P + G + + V I E M+ SLD F ++ + L + I Sbjct: 69 MGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR---FTVIQLVGMLRGI 125 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKP-- 218 +++L S +S +HRD+ N+L+N+ K+ DFG+S L D A T G P Sbjct: 126 GSGMKYL-SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIR 184 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + APE I + ++ SD+WS GI M E ++ PY W Q + + +EE Sbjct: 185 WTAPEAIA----YRKFTSASDVWSYGIVMWEVMSYGERPY--WDMSNQDVIKAIEEGYRL 238 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P C +K +RP + +++ Sbjct: 239 PPPMDCPIALHQLMLDCWQKERSDRPKFGQIVN 271 >5L6P-A nrPDB Length = 298 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 62/274 (22%), Positives = 115/274 (41%), Gaps = 20/274 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDIS 103 E+ ++ +G G +G V + R G+ +A+K ++ ++++ L + I Sbjct: 15 EIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASI- 73 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M D P + G + + V I E M+ + ++ D L + I Sbjct: 74 MGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDG--QFTVIQLVGMLRGIA 131 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD---SVAKTIDAGCK--- 217 +++L S+++ +HRD+ N+L+N+ K+ DFG+S +L D T G K Sbjct: 132 AGMKYL-SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPI 190 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSP 276 + APE I + ++ SD+WS GI M E ++ PY W Q + VE+ Sbjct: 191 RWTAPEAIA----YRKFTSASDVWSYGIVMWEVMSYGERPY--WDMSNQDVINAVEQDYR 244 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P C ++ RP + +++ Sbjct: 245 LPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVN 278 >4L42-A nrPDB Length = 346 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 76/280 (27%), Positives = 129/280 (46%), Gaps = 24/280 (8%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHV---PSGQIMAVKRIRAT---VNSQEQKRLLMDL 100 +++ + E + LG+G YG V ++R V +G+I A+K ++ N+++ + Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 73 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +I + V PF V A G +++ +E + + + Q+ +G + ED Sbjct: 74 NI-LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGG--ELFMQLEREGIFM-EDTACFYLA 129 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPY 219 I AL HLH K +I+RD+KP N+++N G VK+ DFG+ + D G Y Sbjct: 130 EISMALGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 MAPE L + G++ D WSLG M ++ P+ G ++ + + LP Sbjct: 189 MAPEI----LMRSGHNRAVDWWSLGALMYDMLTGAPPF--TGENRKKTIDKILKCKLNLP 242 Query: 280 ADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 + E D + LK+N+ R E+ HPFF Sbjct: 243 P-YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 >2GCD-A nrPDB Length = 309 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 77/278 (27%), Positives = 136/278 (48%), Gaps = 13/278 (4%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK--RLLMDLDISMRTVDCP 110 + E+G G++G V R V + +++A+K++ + +K ++ ++ ++ + P Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVR-FLQKLRHP 75 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 T+ + G RE W+ ME S + + + E + + ++ L +LH Sbjct: 76 NTIQYRGCYLREHTAWLVMEYCLGSASDLLEV---HKKPLQEVEIAAVTHGALQGLAYLH 132 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 S ++IHRDVK N+L++ G VK+ DFG + + + G +MAPE I ++ Sbjct: 133 SH-NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---NSFVGTPYWMAPEVI-LAMD 187 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + Y K D+WSLGIT IELA + P + L + + SP L + +S F +F Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKPPLFNM-NAMSALYHIAQNESPALQSGHWSEYFRNF 246 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFV 328 CL+K ++RPT L++H F L E T + + Sbjct: 247 VDSCLQKIPQDRPTSEVLLKHRFV-LRERPPTVIMDLI 283 >3PPZ-A nrPDB Length = 309 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 130/282 (46%), Gaps = 15/282 (5%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNS 90 +L + + + ++ DL ++G G++G V + G +AVK + ++ Sbjct: 20 NLYFQGAMD--GDDMDIPWCDLNIKEKIGAGSFGTVHRAEW--HGSDVAVKILMEQDFHA 75 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQT 149 + L ++ I M+ + P V F GA+ + ++ I E + SL + + + Q Sbjct: 76 ERVNEFLREVAI-MKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQ- 133 Query: 150 IPEDILGKIAVSIVKALEHLHSK-LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + E +A + K + +LH++ ++HRD+K N+L++ VK+CDFG+S + Sbjct: 134 LDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTF 193 Query: 209 -AKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQL 267 + AG +MAPE + E + + KSD++S G+ + ELA L+ P+ + P Q + Sbjct: 194 LSSKSAAGTPEWMAPEVLRDEPSNE----KSDVYSFGVILWELATLQQPWGNL-NPAQVV 248 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 V + + + C +RP++ +M Sbjct: 249 AAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIM 290 >4B6L-A nrPDB Length = 281 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 121/266 (45%), Gaps = 15/266 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ--EQKRLLMDLDISMRTVDCP 110 LG+G + + +G AVK I + ++ +++++L +++ R + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIE-LHRDLQHR 69 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V F +++I +EL K + T+ E + I+ L++LH Sbjct: 70 HIVRFSHHFEDADNIYIFLELCS---RKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLH 126 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPEL 229 + ++HRD+K N I ++K+ DFG++ L K G Y+APE L Sbjct: 127 QR-GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEV----L 181 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 ++G+ ++D+WSLG M L P+++ ++ + +++ LPA S Sbjct: 182 LRQGHGPEADVWSLGCVMYTLLCGSPPFET--ADLKETYRCIKQVHYTLPA-SLSLPARQ 238 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFT 315 + L+ + ++RP+ ++++H FFT Sbjct: 239 LLAAILRASPRDRPSIDQILRHDFFT 264 >4RLP-A nrPDB Length = 288 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 76/280 (27%), Positives = 129/280 (46%), Gaps = 24/280 (8%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHV---PSGQIMAVKRIRAT---VNSQEQKRLLMDL 100 +++ + E + LG+G YG V ++R V +G+I A+K ++ N+++ + Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +I + V PF V A G +++ +E + + + Q+ +G + ED Sbjct: 61 NI-LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGG--ELFMQLEREGIFM-EDTACFYLA 116 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPY 219 I AL HLH K +I+RD+KP N+++N G VK+ DFG+ + D G Y Sbjct: 117 EISMALGHLHQK-GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 MAPE L + G++ D WSLG M ++ P+ G ++ + + LP Sbjct: 176 MAPEI----LMRSGHNRAVDWWSLGALMYDMLTGAPPF--TGENRKKTIDKILKCKLNLP 229 Query: 280 ADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 + E D + LK+N+ R E+ HPFF Sbjct: 230 P-YLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 >6ED6-A nrPDB Length = 415 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 126/279 (45%), Gaps = 13/279 (4%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDI 102 + ++KA+D + + +GRGA+G V+ +RH S ++ A+K + + + + + Sbjct: 81 RGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERD 140 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 M + P+ V + A + +++ ME M D +PE + Sbjct: 141 IMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD----VPEKWAKFYTAEV 196 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKPYM 220 V AL+ +HS + +IHRDVKP N+L++ G +K+ DFG + ++ V G Y+ Sbjct: 197 VLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYI 255 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 +PE + + Y + D WS+G+ + E+ + P+ + K + + S P Sbjct: 256 SPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPE 315 Query: 281 D-KFSAEFVDFTSQCLKKNSKERP---TYPELMQHPFFT 315 D + S + L + + R E+ QHPFF Sbjct: 316 DAEISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFK 353 >2HAK-A nrPDB Length = 328 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 124/272 (45%), Gaps = 12/272 (4%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCP 110 + +G+G + V+ RHV +G+ +AVK I T +N ++L ++ I M+ ++ P Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRI-MKILNHP 74 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + + E +++ ME + + ++ G+ + E IV A+++ H Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 131 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 K ++HRD+K N+L++ +K+ DFG S G PY APE Sbjct: 132 QKY-IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQ---G 187 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 +K + D+WSLG+ + L P+D G ++L++ V ++P S + + Sbjct: 188 KKYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPF-YMSTDCENL 244 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + L N +R + ++M+ + + + Sbjct: 245 LKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 276 >3A8W-A nrPDB Length = 345 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 70/280 (25%), Positives = 128/280 (45%), Gaps = 25/280 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV--NSQEQKRLLMDLDISMRTVD 108 D + + +GRG+Y V +R + +I A+K ++ + + ++ + + + + + Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 PF V + E ++ +E ++ F+ Q + + +PE+ + I AL + Sbjct: 69 HPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQ---RQRKLPEEHARFYSAEISLALNY 125 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPYMAPERINP 227 LH + +I+RD+K NVL+++ G +K+ D+G+ L + G Y+APE + Sbjct: 126 LHER-GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYD---SWGTPFQ----QLKQVVEEPSPQLPA 280 E Y D W+LG+ M E+ R P+D S P Q L QV+ E ++P Sbjct: 185 E----DYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 240 Query: 281 DKFSAEFVDFTSQCLKKNSKERP------TYPELMQHPFF 314 S + L K+ KER + ++ HPFF Sbjct: 241 -SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFF 279 >2F9G-A nrPDB Length = 353 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 77/322 (23%), Positives = 132/322 (40%), Gaps = 55/322 (17%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + D + LG GAYGVV H P+G+I+A+K+I R L ++ I ++ Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHFKH 68 Query: 110 PFTVTFY-----GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 +T + + +V+I ELM T L + Q + +D + ++ Sbjct: 69 ENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS-----TQMLSDDHIQYFIYQTLR 123 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-----------VAKTID 213 A++ LH +VIHRD+KPSN+LIN+ +K+CDFG++ + +S T Sbjct: 124 AVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEY 182 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVV 271 + Y APE + L YS D+WS G + EL + R P + + ++ Sbjct: 183 VATRWYRAPEVM---LTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Query: 272 EEPS--------------------PQLPA-------DKFSAEFVDFTSQCLKKNSKERPT 304 P P PA + + + +D + L + +R T Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 Query: 305 YPELMQHPFFTLHESKGTDVAS 326 E ++HP+ + + Sbjct: 300 AKEALEHPYLQTYHDPNDEPEG 321 >3OHT-A nrPDB Length = 389 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 80/331 (24%), Positives = 140/331 (42%), Gaps = 48/331 (14%) Query: 31 RDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVN 89 ++ + + +EV + + + +G GAYG V V SG +AVK++ R + Sbjct: 32 KERPTFYRQELNKTIWEVP-ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQS 90 Query: 90 SQEQKRLLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKFYKQV 143 KR +L ++ + + DV++ LM L+ Sbjct: 91 IIHAKRTYRELR-LLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIV--- 146 Query: 144 IDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY 203 K Q + +D + + I++ L+++HS +IHRD+KPSN+ +N ++K+ DFG++ + Sbjct: 147 --KCQKLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVNEDCELKILDFGLARH 203 Query: 204 LVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWG 261 D T + Y APE + LN Y++ DIWS+G M EL R FP Sbjct: 204 TDD--EMTGYVATRWYRAPEIM---LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHI 258 Query: 262 TPFQQLKQVVEEPS-------------------PQLPADKFSAEFV-------DFTSQCL 295 QQ+ ++ P PQ+P F+ F+ D + L Sbjct: 259 NQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKML 318 Query: 296 KKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 ++ +R T E + HP+F+ + + S Sbjct: 319 VLDTDKRITASEALAHPYFSQYHDPDDEPES 349 >3TXO-A nrPDB Length = 353 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 120/292 (41%), Gaps = 21/292 (7%) Query: 34 DSKACISIG-NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV--NS 90 SK IG N + + D+ E I LG+G++G V R +G + AVK ++ V Sbjct: 5 SSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQD 64 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTI 150 + + + + I + PF + ++ ME ++ F+ I K + Sbjct: 65 DDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFH---IQKSRRF 121 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVA 209 E A I+ AL LH K +I+RD+K NVL++ G K+ DFG+ + + V Sbjct: 122 DEARARFYAAEIISALMFLHDK-GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 180 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ 269 G Y+APE + L Y D W++G+ + E+ P+++ L + Sbjct: 181 TATFCGTPDYIAPEILQEML----YGPAVDWWAMGVLLYEMLCGHAPFEAENE--DDLFE 234 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP-TYPE-----LMQHPFFT 315 + P + + KN R + + +++HPFF Sbjct: 235 AILNDEVVYPT-WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFK 285 >1VZO-A nrPDB Length = 355 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 128/284 (45%), Gaps = 22/284 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHV---PSGQIMAVKRIRATVNSQEQK---RLLMDL 100 +V ++ E + LG GAYG V +R + +G++ A+K ++ Q+ K + Sbjct: 50 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 109 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + PF VT + A E + + ++ ++ + + + + + E + Sbjct: 110 QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG--ELFTHLSQRER-FTEHEVQIYVG 166 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT--IDAGCKP 218 IV ALEHLH KL +I+RD+K N+L+++ G V + DFG+S V + G Sbjct: 167 EIVLALEHLH-KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIE 225 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSP 276 YMAP+ + G+ D WSLG+ M EL P+ D ++ + + + P Sbjct: 226 YMAPDIVRG--GDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEP 283 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFFT 315 P + SA D + L K+ K+R E+ +H FF Sbjct: 284 PYPQE-MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 326 >1CM8-A nrPDB Length = 367 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 137/331 (41%), Gaps = 51/331 (15%) Query: 27 STPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-R 85 S+PP + +EV+A + +G GAYG V +G +A+K++ R Sbjct: 2 SSPPPARSGFYRQEVTKTAWEVRA-VYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR 60 Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF------REGDVWICMELMDTSLDKF 139 + KR +L ++ + + D ++ M M T L K Sbjct: 61 PFQSELFAKRAYRELR-LLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKL 119 Query: 140 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 K + + ED + + ++K L ++H+ +IHRD+KP N+ +N ++K+ DFG Sbjct: 120 MKH-----EKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVNEDCELKILDFG 173 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 ++ T + Y APE I LN Y+ DIWS+G M E+ + + Sbjct: 174 LARQA--DSEMTGYVVTRWYRAPEVI---LNWMRYTQTVDIWSVGCIMAEMITGKTLFK- 227 Query: 260 WGTPFQQLKQVVE----------------------EPSPQLPADKF-------SAEFVDF 290 QLK++++ + P+L F S V+ Sbjct: 228 GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNL 287 Query: 291 TSQCLKKNSKERPTYPELMQHPFF-TLHESK 320 + L ++++R T E + HP+F +LH+++ Sbjct: 288 LEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 >3TAC-A nrPDB Length = 361 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 113/280 (40%), Gaps = 19/280 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE----QKRLLMDLDISMRT 106 D E +G+G + VV + + +GQ AVK + + + L + I Sbjct: 26 DVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASI-CHM 84 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKF-YKQVIDKGQTIPEDILGKIAVSIVKA 165 + P V +G +++ E MD + F + D G E + I++A Sbjct: 85 LKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEA 144 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQ---VKMCDFGISGYLVDSVAKTI-DAGCKPYMA 221 L + H ++IHRDVKP VL+ + VK+ FG++ L +S G +MA Sbjct: 145 LRYCHDN-NIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMA 203 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-- 279 PE + ++ Y D+W G+ + L P+ +GT + + +++ P Sbjct: 204 PEVVK----REPYGKPVDVWGCGVILFILLSGCLPF--YGTKERLFEGIIKGKYKMNPRQ 257 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 S D + L + ER T E + HP+ + Sbjct: 258 WSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDR 297 >3KUL-B nrPDB Length = 325 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 118/302 (39%), Gaps = 26/302 (8%) Query: 16 PKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPS 75 + + +P T P R S E++A + +G G G V R Sbjct: 22 EPQFYAEPHTYEEPGRAGRSFTR--------EIEASRIHIEKIIGSGDSGEVCYGRLRVP 73 Query: 76 GQI---MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM 132 GQ +A+K ++A ++++ L + I M D P + G + R I E M Sbjct: 74 GQRDVPVAIKALKAGYTERQRRDFLSEASI-MGQFDHPNIIRLEGVVTRGRLAMIVTEYM 132 Query: 133 DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ 192 + + + D L + + + +L S L +HRD+ NVL+++ Sbjct: 133 ENGSLDTFLRTHDG--QFTIMQLVGMLRGVGAGMRYL-SDLGYVHRDLAARNVLVDSNLV 189 Query: 193 VKMCDFGISGYLVD--SVAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMI 248 K+ DFG+S L D A T G P + APE I + +S SD+WS G+ M Sbjct: 190 CKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIA----FRTFSSASDVWSFGVVMW 245 Query: 249 E-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPE 307 E LA PY W + + VEE C K+ +RP + + Sbjct: 246 EVLAYGERPY--WNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQ 303 Query: 308 LM 309 ++ Sbjct: 304 IV 305 >4D2V-A nrPDB Length = 356 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 114/265 (43%), Gaps = 13/265 (4%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 E +G G + V+ H+ +G+++A+K + + R+ +++ +++ + Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIE-ALKNLRHQHI 89 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 Y L +++ +E + + +I + + + E+ + IV A+ ++HS+ Sbjct: 90 CQLYHVLETANKIFMVLEYCPGG--ELFDYIISQDR-LSEEETRVVFRQIVSAVAYVHSQ 146 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCKPYMAPERINPELN 230 HRD+KP N+L + ++K+ DFG+ + + G Y APE I Sbjct: 147 -GYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQ---G 202 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + ++D+WS+GI + L P+D L + +P S + Sbjct: 203 KSYLGSEADVWSMGILLYVLMCGFLPFDD--DTAAALVAKIMRGKYDVP-KWLSPSSILL 259 Query: 291 TSQCLKKNSKERPTYPELMQHPFFT 315 Q L+ + K+R + L+ HP+ Sbjct: 260 LQQMLQVDPKKRISMKNLLNHPWIM 284 >4RA4-A nrPDB Length = 355 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 121/289 (41%), Gaps = 19/289 (6%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMDLDISM 104 VK D +M LG+G++G V + ++ A+K ++ + + + +++ + Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 PF + ++ ME ++ ++ Q + K E A I Sbjct: 76 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK---FKEPQAVFYAAEISI 132 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKTIDAGCKPYMAPE 223 L LH K +I+RD+K NV++++ G +K+ DFG+ +++D V G Y+APE Sbjct: 133 GLFFLH-KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE 191 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF 283 I + Y D W+ G+ + E+ + P+D G +L Q + E + P Sbjct: 192 IIA----YQPYGKSVDWWAYGVLLYEMLAGQPPFD--GEDEDELFQSIMEHNVSYP-KSL 244 Query: 284 SAEFVDFTSQCLKKNSKERPTY-----PELMQHPFFTLHESKGTDVASF 327 S E V + K+ +R ++ +H FF + + + Sbjct: 245 SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREI 293 >4GS6-A nrPDB Length = 315 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 68/266 (25%), Positives = 117/266 (43%), Gaps = 17/266 (6%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107 + ++E +GRGA+GVV K + + +A+K+I + E+K +++L + V Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE---SESERKAFIVELR-QLSRV 59 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + P V YGA V + ME + + + + + Sbjct: 60 NHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 168 HLHSKLS--VIHRDVKPSNVLINALGQV-KMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 +LHS +IHRD+KP N+L+ A G V K+CDFG + + T + G +MAPE Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ--THMTNNKGSAAWMAPEV 175 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 YS K D++S GI + E+ R P+D G P ++ V + Sbjct: 176 FEGS----NYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP 231 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQ 310 ++C K+ +RP+ E+++ Sbjct: 232 KPIESLMTRCWSKDPSQRPSMEEIVK 257 >4AGU-A nrPDB Length = 311 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 69/294 (23%), Positives = 120/294 (40%), Gaps = 36/294 (12%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + E I ++G G+YGVV K R+ +GQI+A+K+ + + K++ + ++ + Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V R+ + + E D + ++ + +PE ++ I ++A+ Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHT---VLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPE 228 H K + IHRDVKP N+LI +K+CDFG + L S + + Y +PE + Sbjct: 119 H-KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELL--- 174 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ----------------------Q 266 + Y D+W++G EL + Q Q Sbjct: 175 VGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQ 234 Query: 267 LKQVVEEPSP------QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 V+ P P +L S + CL + ER T +L+ HP+F Sbjct: 235 YFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >1FVR-A nrPDB Length = 327 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 116/275 (42%), Gaps = 23/275 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVD 108 +D++ +G G +G V K R G M A+KR++ + + + +L++ + Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 109 CPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVI------------DKGQTIPEDIL 155 P + GA G +++ +E +L F ++ T+ L Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAG 215 A + + +++L S+ IHRD+ N+L+ K+ DFG+S V KT+ Sbjct: 145 LHFAADVARGMDYL-SQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL 203 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEP 274 +MA E +N + Y+ SD+WS G+ + E+ PY G +L + + + Sbjct: 204 PVRWMAIESLNYSV----YTTNSDVWSYGVLLWEIVSLGGTPY--CGMTCAELYEKLPQG 257 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 E D QC ++ ERP++ +++ Sbjct: 258 YRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >4FR4-A nrPDB Length = 384 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 74/267 (27%), Positives = 131/267 (49%), Gaps = 10/267 (3%) Query: 41 IGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLM 98 + ++N +V D E + +G+G++G V ++ + ++ A+K + V E + + Sbjct: 5 VFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFK 64 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 +L I M+ ++ PF V + + E D+++ ++L+ +++ Q + E+ + Sbjct: 65 ELQI-MQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQ---QNVHFKEETVKLF 120 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 +V AL++L +IHRD+KP N+L++ G V + DF I+ L T AG KP Sbjct: 121 ICELVMALDYL-QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKP 179 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD-SWGTPFQQLKQVVEEPSPQ 277 YMAPE + GYS D WSLG+T EL R PY T +++ E Sbjct: 180 YMAPEMFSSR-KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVT 238 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPT 304 P+ +S E V + L+ N +R + Sbjct: 239 YPS-AWSQEMVSLLKKLLEPNPDQRFS 264 >6C9D-A nrPDB Length = 459 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 124/272 (45%), Gaps = 12/272 (4%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VNSQEQKRLLMDLDISMRTVDCP 110 + +G+G + V+ RHV +G+ +AVK I T +N ++L ++ I M+ ++ P Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRI-MKILNHP 80 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + + E +++ ME + + ++ G+ + E IV A+++ H Sbjct: 81 NIVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGR-MKEKEARAKFRQIVSAVQYCH 137 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 K ++HRD+K N+L++ +K+ DFG S G PY APE Sbjct: 138 QKY-IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQ---G 193 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 +K + D+WSLG+ + L P+D G ++L++ V ++P S + + Sbjct: 194 KKYDGPEVDVWSLGVILYTLVSGSLPFD--GQNLKELRERVLRGKYRIPF-YMSTDCENL 250 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGT 322 + L N +R + ++M+ + + + Sbjct: 251 LKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEE 282 >5SYS-A nrPDB Length = 286 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 124/285 (43%), Gaps = 20/285 (7%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 + +E+ + L ++LG+G +G + + +A+K ++ S E L + Sbjct: 7 GLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEA--FLQE 63 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKI 158 + M+ + V Y + E ++I E M SL F K + G+ + L + Sbjct: 64 AQV-MKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGEM--GKYLRLPQLVDM 119 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 A I + ++ +++ +HRD++ +N+L+ K+ DFG++ + D+ P Sbjct: 120 AAQIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 178 Query: 219 --YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPS 275 + APE +++KSD+WS GI + EL R PY G +++ VE Sbjct: 179 IKWTAPE----AALYGRFTIKSDVWSFGILLTELTTKGRVPYP--GMVNREVLDQVERGY 232 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHE 318 + D QC +K+ +ERPT+ L +FT E Sbjct: 233 RMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTE 277 >2R2P-A nrPDB Length = 295 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 118/296 (39%), Gaps = 26/296 (8%) Query: 23 PQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI---M 79 P T P + + A E++A + +G G +G V R G+ + Sbjct: 2 PHTYEDPNQAVHEFAK--------EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPV 53 Query: 80 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKF 139 A+K ++ ++++ L + I M D P + G + + V I E M+ Sbjct: 54 AIKTLKVGYTEKQRRDFLGEASI-MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDT 112 Query: 140 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 + + D L + I +++L S + +HRD+ N+LIN+ K+ DFG Sbjct: 113 FLKKNDG--QFTVIQLVGMLRGISAGMKYL-SDMGYVHRDLAARNILINSNLVCKVSDFG 169 Query: 200 ISGYLVDS--VAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELA-ILR 254 +S L D A T G P + APE I + ++ SD+WS GI M E+ Sbjct: 170 LSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA----FRKFTSASDVWSYGIVMWEVVSYGE 225 Query: 255 FPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 PY W Q + + VEE A C +K RP + E++ Sbjct: 226 RPY--WEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVN 279 >6DTL-A nrPDB Length = 364 Score = 234 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 88/317 (27%), Positives = 142/317 (44%), Gaps = 42/317 (13%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISM 104 FEV A PIM +G+GAYG+V + + + +A+K+I A N + KR L ++ + Sbjct: 25 FEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIK-LL 83 Query: 105 RTVDCPFTVTFYGALFRE-----GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 R +D V + DV+I ELMDT L Q+I Q + E+ Sbjct: 84 RHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDL----HQIIRSNQALSEEHCQYFL 139 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY 219 I++ L+++HS +V+HRD+KPSN+L+NA +K+CDFG++ +S T + Y Sbjct: 140 YQILRGLKYIHS-ANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 198 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVVEEPS-- 275 APE + LN Y+ D+WS+G +EL + P + L +++ PS Sbjct: 199 RAPELL---LNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEE 255 Query: 276 -------------PQLPA-------DKFS---AEFVDFTSQCLKKNSKERPTYPELMQHP 312 QLP DKF +D + L + + R T + + HP Sbjct: 256 ELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHP 315 Query: 313 FFTLHESKGTDVASFVK 329 + + + Sbjct: 316 YLNSLHDISDEPECTIP 332 >6CQF-A nrPDB Length = 297 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 84/276 (30%), Positives = 140/276 (50%), Gaps = 15/276 (5%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 I N++ D + + LG G YG V K R SG ++A+K ++ + + L + Sbjct: 8 DIFNRD---PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDD-DVSTLQKE 63 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + I ++T V ++G+ +WICME + QV ++ E + + Sbjct: 64 ILI-LKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG---SLSELQISYVC 119 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI-DAGCKP 218 +++ L +LHS+ + HRD+K +N+LIN G+V++ DFGIS + ++A+ + G Sbjct: 120 REVLQGLAYLHSQKKI-HRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPY 178 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE---EPS 275 +MAPE L GY+ DIWSLGIT IELA L+ P P + L + + +P Sbjct: 179 WMAPEVAAVALKG-GYNELCDIWSLGITAIELAELQPPLFDVH-PLRVLFLMTKSGYQPP 236 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 K+SA F +F L K+ K+RP+ +++ H Sbjct: 237 RLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >5AWM-A nrPDB Length = 394 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 136/335 (40%), Gaps = 61/335 (18%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + +G+ NF + + + +G GA G+V + Q +A+K++ R N KR Sbjct: 31 YTVEVGDTNFTIHS-RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKR 89 Query: 96 LLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKFYKQVIDKGQT 149 + M+ V+ + A DV++ MELMD +L + + +D Sbjct: 90 AYREFK-LMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQMDLDH--- 145 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 D + + ++ ++HLHS +IHRD+KPSN+++ A +K+ DFG++ + Sbjct: 146 ---DRMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFM 201 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQL 267 T + Y APE I GY+ DIWS+G M E+ FP + ++ Sbjct: 202 MTPYVVTRYYRAPEVILGM----GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKI 257 Query: 268 KQVVEEPSP---------------------------QLPADKFS-----------AEFVD 289 + + PSP P F ++ + Sbjct: 258 IEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARN 317 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFTLH-ESKGTD 323 S+ L + ++R + E ++H + + +++ D Sbjct: 318 LLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVD 352 >5N23-A nrPDB Length = 352 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 71/275 (25%), Positives = 128/275 (46%), Gaps = 20/275 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVD 108 D E I LG G++G V ++H +G A+K + + V ++ + L + I + V+ Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQ-QAVN 100 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 PF V + ++++ +E + + + G+ E A IV E+ Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGG--EMFSHLRRIGR-FSEPHARFYAAQIVLTFEY 157 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 LHS L +I+RD+KP N+LI+ G +K+ DFG + + T+ G Y+APE I Sbjct: 158 LHS-LDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTL-CGTPEYLAPEII--- 212 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 KGY+ D W+LG+ + E+A P+ + P Q +++V + P+ FS++ Sbjct: 213 -LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIVS-GKVRFPS-HFSSDLK 268 Query: 289 DFTSQCLKKNSKERP-----TYPELMQHPFFTLHE 318 D L+ + +R ++ H +F + Sbjct: 269 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 303 >1JPA-A nrPDB Length = 312 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 123/313 (39%), Gaps = 36/313 (11%) Query: 10 NPGLKI--PKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV 67 PG+KI FE P + E+ ++ +G G +G V Sbjct: 4 TPGMKIFIDPFTFEDPNEAVREFAK--------------EIDISCVKIEQVIGAGEFGEV 49 Query: 68 EKMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD 124 G+ +A+K +++ ++++ L + I M D P + G + + Sbjct: 50 CSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASI-MGQFDHPNVIHLEGVVTKSTP 108 Query: 125 VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 V I E M+ + + D L + I +++L + ++ +HRD+ N Sbjct: 109 VMIITEFMENGSLDSFLRQNDG--QFTVIQLVGMLRGIAAGMKYL-ADMNYVHRDLAARN 165 Query: 185 VLINALGQVKMCDFGISGYLVDSV---AKTIDAGCK---PYMAPERINPELNQKGYSVKS 238 +L+N+ K+ DFG+S +L D T G K + APE I + ++ S Sbjct: 166 ILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI----QYRKFTSAS 221 Query: 239 DIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKK 297 D+WS GI M E ++ PY W Q + +E+ P + C +K Sbjct: 222 DVWSYGIVMWEVMSYGERPY--WDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQK 279 Query: 298 NSKERPTYPELMQ 310 + RP + +++ Sbjct: 280 DRNHRPKFGQIVN 292 >3GUB-A nrPDB Length = 295 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 131/289 (45%), Gaps = 23/289 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-----RLLMDLDISMR 105 D + ELG G + VV+K R +G A K I+ ++ + ++ I ++ Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI-LK 69 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + P +T + + DV + EL+ + + + +K +++ E+ + I+ Sbjct: 70 EIQHPNVITLHEVYENKTDVILIGELVAGG--ELFDFLAEK-ESLTEEEATEFLKQILNG 126 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALG----QVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 + +LHS L + H D+KP N+++ ++K+ DFG++ + G ++A Sbjct: 127 VYYLHS-LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVA 185 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 PE + N + +++D+WS+G+ L P+ G Q+ V + + + Sbjct: 186 PEIV----NYEPLGLEADMWSIGVITYILLSGASPF--LGDTKQETLANVSAVNYEFEDE 239 Query: 282 KF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASF 327 F SA DF + L K+ K+R T + +QHP+ +++ +++ Sbjct: 240 YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSSAW 288 >4KRC-A nrPDB Length = 317 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 120/300 (40%), Gaps = 39/300 (13%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + + + +LG G Y V K + +G +A+K ++ + ++ M+ + Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREIS-LMKELKH 62 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFY--KQVIDKGQTIPEDILGKIAVSIVKALE 167 V Y + E + + E MD L K+ + V + + + +++ +++ L Sbjct: 63 ENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERIN 226 H ++HRD+KP N+LIN GQ+K+ DFG++ + + + Y AP+ + Sbjct: 123 FCHEN-KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVL- 180 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRF-------------PYDSWGTPFQQLK----- 268 + + YS DIWS G + E+ + +D GTP + L Sbjct: 181 --MGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTK 238 Query: 269 ------QVVEEPSPQLP-------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + P L + +DF L+ N R + + + HP+F Sbjct: 239 LPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 >5FM2-A nrPDB Length = 355 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 68/339 (20%), Positives = 139/339 (41%), Gaps = 48/339 (14%) Query: 10 NPGLKIPKEAFEQPQTSSTPPRDLDSKACIS----------IGNQNFEVKADDLEPIMEL 59 + + + A P + S+ S + + + +E +L L Sbjct: 13 SAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTL 72 Query: 60 GRGAYGVVEKM-----RHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 G G +G V K + +AVK ++ + E + LL + ++ ++ V+ P + Sbjct: 73 GEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNV-LKQVNHPHVIK 131 Query: 115 FYGALFREGDVWICMELMD-TSLDKFYKQVIDKG--------------------QTIPED 153 YGA ++G + + +E SL F ++ G + + Sbjct: 132 LYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMG 191 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-TI 212 L A I + +++L +++ ++HRD+ N+L+ ++K+ DFG+S + + + Sbjct: 192 DLISFAWQISQGMQYL-AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKR 250 Query: 213 DAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQ 269 G P +MA E + + Y+ +SD+WS G+ + E+ PY G P ++L Sbjct: 251 SQGRIPVKWMAIESLFDHI----YTTQSDVWSFGVLLWEIVTLGGNPYP--GIPPERLFN 304 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +++ D S E QC K+ +RP + ++ Sbjct: 305 LLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >2DQ7-X nrPDB Length = 283 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 69/279 (24%), Positives = 121/279 (43%), Gaps = 20/279 (7%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + L+ I LG G +G V +A+K ++ S E L + I M+ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPE--SFLEEAQI-MK 59 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + V Y + E ++I E M+ SL F K +G+ + L +A + Sbjct: 60 KLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKD--GEGRALKLPNLVDMAAQVAA 116 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAP 222 + ++ +++ IHRD++ +N+L+ K+ DFG++ + D+ P + AP Sbjct: 117 GMAYI-ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAP 175 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 E +++KSD+WS GI + EL R PY G +++ + VE Sbjct: 176 E----AALYGRFTIKSDVWSFGILLTELVTKGRVPYP--GMNNREVLEQVERGYRMPCPQ 229 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHE 318 + C KK+ +ERPT+ L +FT E Sbjct: 230 DCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATE 268 >4XLV-A nrPDB Length = 328 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 130/326 (39%), Gaps = 34/326 (10%) Query: 11 PGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEK- 69 G P A P+ S S +EV + + + ELG+G++G+V + Sbjct: 3 DGPLGPLFASSNPEYLSASDVFPSSVYVPD----EWEVSREKITLLRELGQGSFGMVYEG 58 Query: 70 -MRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV 125 R + G+ +AVK + + + +E+ L + + M+ C V G + + Sbjct: 59 NARDIIKGEAETRVAVKTVNESASLRERIEFLNEASV-MKGFTCHHVVRLLGVVSKGQPT 117 Query: 126 WICMELMDTSLDKFYKQVID-------KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 + MELM K Y + + + ++A I + +L++K +HR Sbjct: 118 LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-KFVHR 176 Query: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYS 235 D+ N ++ VK+ DFG++ + ++ +MAPE + + ++ Sbjct: 177 DLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV----FT 232 Query: 236 VKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 SD+WS G+ + E+ L PY +Q+ + V + D D C Sbjct: 233 TSSDMWSFGVVLWEITSLAEQPYQGLSN--EQVLKFVMDGGYLDQPDNCPERVTDLMRMC 290 Query: 295 LKKNSKERPTYPELMQ------HPFF 314 + N RPT+ E++ HP F Sbjct: 291 WQFNPNMRPTFLEIVNLLKDDLHPSF 316 >2A27-A nrPDB Length = 321 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 23/282 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-----RLLMDLDISMR 105 D + ELG G + +V+K R +G A K I+ + ++ + ++ I +R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI-LR 70 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 V +T + DV + +EL+ + + + K +++ E+ I+ Sbjct: 71 QVLHHNVITLHDVYENRTDVVLILELVSGG--ELFDFLAQK-ESLSEEEATSFIKQILDG 127 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALG----QVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 + +LH+K + H D+KP N+++ +K+ DFG++ + D V G ++A Sbjct: 128 VNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 PE + N + +++D+WS+G+ L P+ G Q+ + S + Sbjct: 187 PEIV----NYEPLGLEADMWSIGVITYILLSGASPF--LGDTKQETLANITAVSYDFDEE 240 Query: 282 KFSAE---FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 FS DF + L K +++R T E ++HP+ T +++ Sbjct: 241 FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQ 282 >3PFQ-A nrPDB Length = 674 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 130/320 (40%), Gaps = 22/320 (6%) Query: 5 KGKKRNPGL--KIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 +G + N L K + Q + + GN++ +K D +M LG+G Sbjct: 294 EGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRD-RMKLTDFNFLMVLGKG 352 Query: 63 AYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 ++G V + ++ AVK ++ + + + +++ + PF + Sbjct: 353 SFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQ 412 Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 ++ ME ++ ++ Q + + E A I L L SK +I+RD+ Sbjct: 413 TMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYAAEIAIGLFFLQSK-GIIYRDL 468 Query: 181 KPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSD 239 K NV++++ G +K+ DFG+ + D V G Y+APE I + Y D Sbjct: 469 KLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA----YQPYGKSVD 524 Query: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNS 299 W+ G+ + E+ + P++ G +L Q + E + P S E V + K+ Sbjct: 525 WWAFGVLLYEMLAGQAPFE--GEDEDELFQSIMEHNVAYP-KSMSKEAVAICKGLMTKHP 581 Query: 300 KERPTY-----PELMQHPFF 314 +R ++ +H FF Sbjct: 582 GKRLGCGPEGERDIKEHAFF 601 >2VWV-A nrPDB Length = 302 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 116/273 (42%), Gaps = 20/273 (7%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQI---MAVKRIRATVNSQEQKRLLMDLDIS 103 E+ ++ +G G +G V + R G+ +A+K ++ ++++ L + I Sbjct: 12 EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASI- 70 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M + P + G + V I E M+ + ++ D L + I Sbjct: 71 MGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDG--QFTVIQLVGMLRGIA 128 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV---AKTIDAGCK--- 217 + +L +++S +HRD+ N+L+N+ K+ DFG+S +L ++ +T G K Sbjct: 129 SGMRYL-AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPI 187 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSP 276 + APE I + ++ SD WS GI M E ++ PY W Q + +E+ Sbjct: 188 RWTAPEAIA----FRKFTSASDAWSYGIVMWEVMSFGERPY--WDMSNQDVINAIEQDYR 241 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 P C +K+ RP +P+++ Sbjct: 242 LPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVV 274 >5DYK-A nrPDB Length = 853 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 127/279 (45%), Gaps = 18/279 (6%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLD 101 Q+ +V+ D+LE +GRG +G V+ + H P+ A+K + R+ +N +Q + ++ + Sbjct: 532 QDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLERE 591 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 I+ D PF + + EL+ + Y + G + + S Sbjct: 592 ITAEN-DHPFIIRLVRTFKDSKYFYFLTELVTGG--ELYDAIRKLG-LLSKSQAQFYLGS 647 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 I+ A+E+LH + ++++RD+KP N+L++ G VK+ DFG + + G YMA Sbjct: 648 IILAIEYLHER-NIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAY--TLVGTPHYMA 704 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 PE I KGY DIW+LGI + E P+ + ++ + + P Sbjct: 705 PEVI----LGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDY 760 Query: 282 KFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFFT 315 + ++ + L + + R + ++ HPFF+ Sbjct: 761 VTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFS 799 >3A4O-X nrPDB Length = 286 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 70/281 (24%), Positives = 127/281 (45%), Gaps = 19/281 (6%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + ++ + LG G +G V + S +AVK ++ S + ++ M+ Sbjct: 8 WEIPRESIKLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMSVQ---AFLEEANLMK 63 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 T+ V Y + RE ++I E M SL F K D+G + L + I + Sbjct: 64 TLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKS--DEGGKVLLPKLIDFSAQIAE 121 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAP 222 + ++ K + IHRD++ +NVL++ K+ DFG++ + D+ + P + AP Sbjct: 122 GMAYIERK-NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 180 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 E I N +++KSD+WS GI + E+ + PY G + + + + Sbjct: 181 EAI----NFGCFTIKSDVWSFGILLYEIVTYGKIPYP--GRTNADVMTALSQGYRMPRVE 234 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPEL--MQHPFFTLHESK 320 E D C K+ ++ERPT+ L + F+T E + Sbjct: 235 NCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQ 275 >4H1J-A nrPDB Length = 293 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 118/281 (41%), Gaps = 17/281 (6%) Query: 35 SKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR---HVPSGQIMAVKRIRATVNSQ 91 S + G+ + + +D+ LG G +G V + H +AVK + Sbjct: 8 SSGLVPRGSPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLD 67 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 +++ + + I M+ +D P V G + E WI MEL + + ++ Sbjct: 68 NKEKFMSEAVI-MKNLDHPHIVKLIGIIEEE-PTWIIMELYPYG--ELGHYLERNKNSLK 123 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 L ++ I KA+ +L S ++ +HRD+ N+L+ + VK+ DFG+S Y+ D Sbjct: 124 VLTLVLYSLQICKAMAYLES-INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYK 182 Query: 212 IDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLK 268 P +M+PE I N + ++ SD+W + M E+ + P+ + Sbjct: 183 ASVTRLPIKWMSPESI----NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENK--DVI 236 Query: 269 QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 V+E+ D ++C + +RP + EL+ Sbjct: 237 GVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELV 277 >4EWQ-A nrPDB Length = 383 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 130/327 (39%), Gaps = 48/327 (14%) Query: 27 STPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-R 85 S ++ + + +EV + + + +G GAYG V +G +AVK++ R Sbjct: 22 SNASQERPTFYRQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR 80 Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKF 139 + KR +L ++ + + DV++ LM L+ Sbjct: 81 PFQSIIHAKRTYRELR-LLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNI 139 Query: 140 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 K Q + +D + + I++ L+++HS +IHRD+KPSN+ +N ++K+ DFG Sbjct: 140 V-----KCQKLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVNEDCELKILDFG 193 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPY 257 ++ + D T + Y APE + LN Y+ DIWS+G M EL R FP Sbjct: 194 LARHTDD--EMTGYVATRWYRAPEIM---LNWMHYNQTVDIWSVGCIMAELLTGRTLFPG 248 Query: 258 DSWGTPFQQLKQVVEEPSPQLPADKFSAEFV--------------------------DFT 291 + + ++V P +L S D Sbjct: 249 TDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLL 308 Query: 292 SQCLKKNSKERPTYPELMQHPFFTLHE 318 + L +S +R T + + H +F + Sbjct: 309 EKMLVLDSDKRITAAQALAHAYFAQYH 335 >5X3F-B nrPDB Length = 393 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 70/277 (25%), Positives = 129/277 (46%), Gaps = 21/277 (7%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRT 106 + D + I LG G++G V ++H SG A+K + + V ++ + L + I ++ Sbjct: 82 QLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRI-LQA 140 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V+ PF V + ++++ ME + + + + G+ E A IV Sbjct: 141 VNFPFLVKLEFSFKDNSNLYMVMEYVAGG--EMFSHLRRIGR-FSEPHARFYAAQIVLTF 197 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 E+LHS L +I+RD+KP N+LI+ G +++ DFG + + G Y+APE I Sbjct: 198 EYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEII- 253 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 KGY+ D W+LG+ + E+A P+ + P Q +++V + P+ FS++ Sbjct: 254 ---LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIVS-GKVRFPS-HFSSD 307 Query: 287 FVDFTSQCLKKNSKERP-----TYPELMQHPFFTLHE 318 D L+ + +R ++ H +F + Sbjct: 308 LKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 344 >2XNP-A nrPDB Length = 279 Score = 230 bits (588), Expect = 4e-61, Method: Composition-based stats. Identities = 70/274 (25%), Positives = 135/274 (49%), Gaps = 14/274 (5%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 +A+D E + +G G+YG +K+R G+I+ K + ++ +K++L+ +R + Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63 Query: 109 CPFTVTFYGALFREGD--VWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 P V +Y + + ++I ME + L + + Q + E+ + ++ + A Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 166 LEHLHSKLS----VIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYM 220 L+ H + V+HRD+KP+NV ++ VK+ DFG++ L D+ G YM Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYM 183 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 +PE ++N+ Y+ KSDIWSLG + EL L P+ ++ +L + E + Sbjct: 184 SPE----QMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQK--ELAGKIREGKFRRIP 237 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 ++S E + ++ L RP+ E++++P Sbjct: 238 YRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >1ZWS-A nrPDB Length = 288 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 23/282 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-----RLLMDLDISMR 105 D + ELG G + +V+K R +G A K I+ + ++ + ++ I +R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSI-LR 70 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 V +T + DV + +EL+ + + + K +++ E+ I+ Sbjct: 71 QVLHHNVITLHDVYENRTDVVLILELVSGG--ELFDFLAQK-ESLSEEEATSFIKQILDG 127 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALG----QVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 + +LH+K + H D+KP N+++ +K+ DFG++ + D V G ++A Sbjct: 128 VNYLHTK-KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVA 186 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 PE + N + +++D+WS+G+ L P+ G Q+ + S + Sbjct: 187 PEIV----NYEPLGLEADMWSIGVITYILLSGASPF--LGDTKQETLANITSVSYDFDEE 240 Query: 282 KF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 F S DF + L K +++R T E ++HP+ T +++ Sbjct: 241 FFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQ 282 >6E4F-A nrPDB Length = 290 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 76/286 (26%), Positives = 134/286 (46%), Gaps = 26/286 (9%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNS 90 +L + +G ++E+ DL + ELG G +GVV+ + GQ +A+K I+ S Sbjct: 12 NLYFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMS 69 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQT 149 +++ ++ M + V YG ++ ++I E M + L + +++ + QT Sbjct: 70 EDE---FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT 126 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 L ++ + +A+E+L SK +HRD+ N L+N G VK+ DFG+S Y++D Sbjct: 127 ---QQLLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD-E 181 Query: 210 KTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTP-- 263 T G K + PE L +S KSDIW+ G+ M E+ + PY+ + Sbjct: 182 YTSSVGSKFPVRWSPPEV----LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSET 237 Query: 264 FQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + Q + P L S + C + + ERPT+ L+ Sbjct: 238 AEHIAQGLRLYRPHLA----SEKVYTIMYSCWHEKADERPTFKILL 279 >6CMJ-A nrPDB Length = 321 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 138/311 (44%), Gaps = 25/311 (8%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--- 93 +SI V+ D E+G+G+YGVV+ + A+K + ++ Sbjct: 20 HHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGC 79 Query: 94 -------KRLLMDLDISMRTVDCPFTVTFYGALFR--EGDVWICMELMDTSLDKFYKQVI 144 +++ ++ I ++ +D P V L E +++ EL++ + Sbjct: 80 IQPRGPIEQVYQEIAI-LKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV----MEV 134 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 + + ED ++K +E+LH + +IHRD+KPSN+L+ G +K+ DFG+S Sbjct: 135 PTLKPLSEDQARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGVSNEF 193 Query: 205 VDSVA-KTIDAGCKPYMAPERINPELNQKGYSVKS-DIWSLGITMIELAILRFPYDSWGT 262 S A + G +MAPE ++ +K +S K+ D+W++G+T+ + P+ Sbjct: 194 KGSDALLSNTVGTPAFMAPESLSE--TRKIFSGKALDVWAMGVTLYCFVFGQCPF--MDE 249 Query: 263 PFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 L ++ + + P + + D ++ L KN + R PE+ HP+ T H ++ Sbjct: 250 RIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEP 309 Query: 322 TDVASFVKLIL 332 ++ Sbjct: 310 LPSEDENCTLV 320 >3UTO-A nrPDB Length = 573 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 122/280 (43%), Gaps = 16/280 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D + ELG GA+GVV ++ +G A K + T + +++ + ++ +M + P Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQ-TMSVLRHP 214 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + A + ++ + E M + +++V D+ + ED + + K L H+H Sbjct: 215 TLVNLHDAFEDDNEMVMIYEFMSGG--ELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 272 Query: 171 SKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 + +H D+KP N++ ++K+ DFG++ +L + + G + APE Sbjct: 273 EN-NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEV---- 327 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS---A 285 K +D+WS+G+ L P+ G + + V+ + FS Sbjct: 328 AEGKPVGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSCDWNMDDSAFSGISE 385 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVA 325 + DF + L + R T + ++HP+ T + G D Sbjct: 386 DGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQ 425 >1JNK-A nrPDB Length = 423 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 72/330 (21%), Positives = 134/330 (40%), Gaps = 59/330 (17%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQE 92 + + +G+ F V + + +G GA G+V + +A+K++ R N Sbjct: 46 NQFYSVEVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 104 Query: 93 QKRLLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKFYKQVIDK 146 KR +L + M+ V+ ++ DV++ MELMD +L + + +D Sbjct: 105 AKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH 163 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 + + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ Sbjct: 164 ER------MSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 216 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPF 264 S T + Y APE I GY DIWS+G M E+ + FP + + Sbjct: 217 SFMMTPYVVTRYYRAPEVILGM----GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQW 272 Query: 265 QQLKQVVEEPSPQ---------------------------LPADKFSAE----------F 287 ++ + + P P+ P F A+ Sbjct: 273 NKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQA 332 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 D S+ L + +R + + +QHP+ + Sbjct: 333 RDLLSKMLVIDPAKRISVDDALQHPYINVW 362 >4XUF-A nrPDB Length = 297 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 66/295 (22%), Positives = 117/295 (39%), Gaps = 39/295 (13%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRH---VPSGQ--IMAVKRIRATVNSQEQKRLLMD 99 +E ++LE LG GA+G V +G +AVK ++ +S E++ L+ + Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSE 62 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK-- 157 L + + V GA G +++ E + K + ED + Sbjct: 63 LKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYG--DLLNYLRSKREKFSEDEIEYEN 120 Query: 158 --------------------IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 A + K +E L K S +HRD+ NVL+ VK+CD Sbjct: 121 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICD 179 Query: 198 FGISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 254 FG++ ++ + + +MAPE + + Y++KSD+WS GI + E+ L Sbjct: 180 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGI----YTIKSDVWSYGILLWEIFSLG 235 Query: 255 F-PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 PY ++++ + E C +S++RP++P L Sbjct: 236 VNPYPGIPVDAN-FYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >2X4F-A nrPDB Length = 373 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 131/288 (45%), Gaps = 27/288 (9%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG G +G V K +G +A K I+ T ++++ + ++ + M +D + Y Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIK-TRGMKDKEEVKNEISV-MNQLDHANLIQLY 152 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 A + D+ + ME +D + + ++ID+ + E I + + H+H ++ ++ Sbjct: 153 DAFESKNDIVLVMEYVDGG--ELFDRIIDESYNLTELDTILFMKQICEGIRHMH-QMYIL 209 Query: 177 HRDVKPSNVL-INAL-GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY 234 H D+KP N+L +N Q+K+ DFG++ ++ G ++APE +N + Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDF----V 265 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF---SAEFVDFT 291 S +D+WS+G+ L P+ G + + L ++F S E +F Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPF--LGDNDAETLNNILACRWDLEDEEFQDISEEAKEFI 323 Query: 292 SQCLKKNSKERPTYPELMQHPFFTLH-----------ESKGTDVASFV 328 S+ L K R + E ++HP+ + H +++G+D FV Sbjct: 324 SKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQKKKNRGSDAQDFV 371 >2OU7-A nrPDB Length = 335 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 62/259 (23%), Positives = 118/259 (45%), Gaps = 13/259 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SMRTVDCPFTVTFYG 117 LG+G + ++ + ++ A K + ++ + +R M ++I R++ V F+G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 V++ +EL + ++ + + + E IV ++LH VIH Sbjct: 109 FFEDNDFVFVVLELCR---RRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN-RVIH 164 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 RD+K N+ +N +VK+ DFG++ + D K + G Y+APE ++ +KG+S Sbjct: 165 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLS----KKGHSF 220 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296 + D+WS+G M L + + P+++ L+ E S + + L+ Sbjct: 221 EVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSI---PKHINPVAASLIQKMLQ 277 Query: 297 KNSKERPTYPELMQHPFFT 315 + RPT EL+ FFT Sbjct: 278 TDPTARPTINELLNDEFFT 296 >5X5O-A nrPDB Length = 310 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 123/275 (44%), Gaps = 21/275 (7%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 + G ++K DDL+ G G++G V + + + + +AVK++ ++ Sbjct: 1 GAMGSGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL---------LKI 51 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVI-DKGQTIPEDIL 155 + +I + + + FYG + + I E SL Y + ++ + + D + Sbjct: 52 EKEAEI-LSVLSHRNIIQFYGVILEPPNYGIVTEY--ASLGSLYDYINSNRSEEMDMDHI 108 Query: 156 GKIAVSIVKALEHLHSK--LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID 213 A + K + +LH + + VIHRD+K NV+I A G +K+CDFG S + + ++ Sbjct: 109 MTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL- 167 Query: 214 AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 G P+MAPE I S D +S G+ + E+ P+ Q VVE+ Sbjct: 168 VGTFPWMAPEVI----QSLPVSETCDTYSYGVVLWEMLTREVPFKGL-EGLQVAWLVVEK 222 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 F + QC + ++K+RP++ ++ Sbjct: 223 NERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQI 257 >2HK5-A nrPDB Length = 270 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 124/267 (46%), Gaps = 18/267 (6%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E+ + L+ +LG G +G V + +AVK ++ S E L + ++ M+ Sbjct: 10 WEIPRESLKLEKKLGAGQFGEVWMATYNKH-TKVAVKTMKPGSMSVEA--FLAEANV-MK 65 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 T+ V + + +E ++I E M SL F K D+G P L + I + Sbjct: 66 TLQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKS--DEGSKQPLPKLIDFSAQIAE 122 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAP 222 + + + + IHRD++ +N+L++A K+ DFG++ + D+ + P + AP Sbjct: 123 GMAFIEQR-NYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 181 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 E I N +++KSD+WS GI ++E+ R PY P ++ + +E + Sbjct: 182 EAI----NFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNP--EVIRALERGYRMPRPE 235 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPEL 308 E + +C K +ERPT+ + Sbjct: 236 NCPEELYNIMMRCWKNRPEERPTFEYI 262 >5X02-A nrPDB Length = 347 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 126/335 (37%), Gaps = 45/335 (13%) Query: 11 PGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQN------FEVKADDLEPIMELGRGAY 64 PG K K+ + Q + + +E ++LE LG GA+ Sbjct: 2 PGHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAF 61 Query: 65 GVVEKMRH---VPSGQ--IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119 G V +G +AVK ++ +S E++ L+ +L + + V GA Sbjct: 62 GKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGAC 121 Query: 120 FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK---------------------- 157 G +++ E + K + ED + Sbjct: 122 TLSGPIYLIFEYCCYG--DLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLC 179 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217 A + K +E L K S +HRD+ NVL+ VK+CDFG++ ++ + + Sbjct: 180 FAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNAR 238 Query: 218 ---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVEE 273 +MAPE + + Y++KSD+WS GI + E+ L PY ++++ Sbjct: 239 LPVKWMAPESLFEGI----YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN-FYKLIQN 293 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + E C +S++RP++P L Sbjct: 294 GFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >6E2O-A nrPDB Length = 295 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 7/265 (2%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+G YG+V R + + +A+K I + Q L + + + V + G Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQP--LHEEIALHKHLKHKNIVQYLG 86 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + G + I ME + + E +G I++ L++LH ++H Sbjct: 87 SFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN-QIVH 145 Query: 178 RDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKT-IDAGCKPYMAPERINPELNQKGYS 235 RD+K NVLIN G +K+ DFG S L T G YMAPE I+ +GY Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDK--GPRGYG 203 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 +DIWSLG T+IE+A + P+ G P + +V + SAE F +C Sbjct: 204 KAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCF 263 Query: 296 KKNSKERPTYPELMQHPFFTLHESK 320 + + +R +L+ F + K Sbjct: 264 EPDPDKRACANDLLVDEFLKVSSKK 288 >3DTC-A nrPDB Length = 271 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 113/277 (40%), Gaps = 26/277 (9%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL--MDLDIS 103 E+ +L +G G +G V + + G +AVK R + + + Sbjct: 2 LEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKL 59 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSI 162 + P + G +E ++ + ME L++ G+ IP DIL AV I Sbjct: 60 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-----GKRIPPDILVNWAVQI 114 Query: 163 VKALEHLHSK--LSVIHRDVKPSNVLI--------NALGQVKMCDFGISGYLVDSVAKTI 212 + + +LH + + +IHRD+K SN+LI + +K+ DFG++ + + Sbjct: 115 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA 174 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 AG +MAPE I + +S SD+WS G+ + EL P+ + Sbjct: 175 -AGAYAWMAPEVIRASM----FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMN 229 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + +P+ F C + RP++ ++ Sbjct: 230 KLALPIPS-TCPEPFAKLMEDCWNPDPHSRPSFTNIL 265 >2I0E-A nrPDB Length = 353 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 120/281 (42%), Gaps = 20/281 (7%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMD 99 GN++ +K D +M LG+G++G V + ++ AVK ++ + + + +++ Sbjct: 12 GNRD-RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVE 70 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + PF + ++ ME ++ ++ Q + + E A Sbjct: 71 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR---FKEPHAVFYA 127 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKP 218 I L L SK +I+RD+K NV++++ G +K+ DFG+ + D V G Sbjct: 128 AEIAIGLFFLQSK-GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 186 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Y+APE I + Y D W+ G+ + E+ + P++ G +L Q + E + Sbjct: 187 YIAPEIIA----YQPYGKSVDWWAFGVLLYEMLAGQAPFE--GEDEDELFQSIMEHNVAY 240 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTY-----PELMQHPFF 314 P S E V + K+ +R ++ +H FF Sbjct: 241 P-KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF 280 >3FI2-A nrPDB Length = 353 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 142/354 (40%), Gaps = 66/354 (18%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQE 92 + + +G+ F V + + +G GA G+V + +A+K++ R N Sbjct: 8 NQFYSVEVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH 66 Query: 93 QKRLLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKFYKQVIDK 146 KR +L + M+ V+ ++ DV++ MELMD +L + + +D Sbjct: 67 AKRAYREL-VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDH 125 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 + + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ Sbjct: 126 ER------MSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT 178 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPF 264 S T + Y APE I GY DIWS+G M E+ + FP + + Sbjct: 179 SFMMTPYVVTRYYRAPEVILGM----GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQW 234 Query: 265 QQLKQVVEEPSPQ---------------------------LPADKFSAE----------F 287 ++ + + P P+ P F A+ Sbjct: 235 NKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQA 294 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFTLH-------ESKGTDVASFVKLILGD 334 D S+ L + +R + + +QHP+ + + + + + +LI + Sbjct: 295 RDLLSKMLVIDPAKRISVDDALQHPYINVWYXXXXXXDEREHTIEEWKELIYKE 348 >4WB7-A nrPDB Length = 405 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 128/275 (46%), Gaps = 21/275 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVD 108 D E I LG G++G V ++H +G A+K + + V ++ + L + I ++ V+ Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRI-LQAVN 154 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 PF V + ++++ ME + + + + G+ E A IV E+ Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGG--EMFSHLRRIGR-FSEPHARFYAAQIVLTFEY 211 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 LHS L +I+RD+KP N+LI+ G +++ DFG + + G Y+APE I Sbjct: 212 LHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEII--- 265 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFV 288 KGY+ D W+LG+ + E+A P+ + P Q +++V + P+ FS++ Sbjct: 266 -LSKGYNKAVDWWALGVLIYEMAAGYPPFFA-DQPIQIYEKIVS-GKVRFPS-HFSSDLK 321 Query: 289 DFTSQCLKKNSKERP-----TYPELMQHPFFTLHE 318 D L+ + +R ++ H +F + Sbjct: 322 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 356 >4UY9-A nrPDB Length = 323 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 113/277 (40%), Gaps = 26/277 (9%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL--MDLDIS 103 E+ +L +G G +G V + + G +AVK R + + + Sbjct: 4 LEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKL 61 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSI 162 + P + G +E ++ + ME L++ G+ IP DIL AV I Sbjct: 62 FAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS-----GKRIPPDILVNWAVQI 116 Query: 163 VKALEHLHSK--LSVIHRDVKPSNVLI--------NALGQVKMCDFGISGYLVDSVAKTI 212 + + +LH + + +IHRD+K SN+LI + +K+ DFG++ + + Sbjct: 117 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA 176 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 AG +MAPE I + +S SD+WS G+ + EL P+ + Sbjct: 177 -AGTYAWMAPEVIRASM----FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMN 231 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + +P+ F C + RP++ ++ Sbjct: 232 KLALPIPS-TCPEPFAKLMEDCWNPDPHSRPSFTNIL 267 >3DB8-A nrPDB Length = 317 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 119/268 (44%), Gaps = 13/268 (4%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SMRTVD 108 LG+G + ++ + + ++ A K + ++ + ++ M +I +++D Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V F+G + V++ +E+ + ++ + + + E ++ +++ Sbjct: 101 NPHVVGFHGFFEDDDFVYVVLEICR---RRSLLELHKRRKAVTEPEARYFMRQTIQGVQY 157 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINP 227 LH+ VIHRD+K N+ +N VK+ DFG++ + D K G Y+APE + Sbjct: 158 LHNN-RVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLC- 215 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 +KG+S + DIWSLG + L + + P+++ ++ E S + Sbjct: 216 ---KKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSV---PRHINPVA 269 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFT 315 + L + RP+ EL+ FFT Sbjct: 270 SALIRRMLHADPTLRPSVAELLTDEFFT 297 >4XI2-A nrPDB Length = 446 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 74/293 (25%), Positives = 137/293 (46%), Gaps = 26/293 (8%) Query: 25 TSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKR 83 ++ ++ + +G ++E+ DL + ELG G +GVV+ + GQ +A+K Sbjct: 161 KYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKM 218 Query: 84 IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQ 142 IR S+++ ++ M + V YG ++ ++I E M + L + ++ Sbjct: 219 IREGSMSEDE---FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLRE 275 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + QT L ++ + +A+E+L SK +HRD+ N L+N G VK+ DFG+S Sbjct: 276 MRHRFQT---QQLLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGLSR 331 Query: 203 YLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYD 258 Y++D T G K + PE L +S KSDIW+ G+ M E+ + PY+ Sbjct: 332 YVLDD-EYTSSVGSKFPVRWSPPEV----LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE 386 Query: 259 SWGTPF--QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + + Q + P L +++ C + + ERP++ L+ Sbjct: 387 RFTNSETAEHIAQGLRLYRPHLASERV----YTIMYSCWHEKADERPSFKILL 435 >5GRN-A nrPDB Length = 356 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 112/298 (37%), Gaps = 38/298 (12%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQ-----IMAVKRIRATVNSQEQKRLL 97 + +E D L LG GA+G V + + +AVK ++ T S E++ L+ Sbjct: 38 DSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALM 97 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVID----------- 145 +L I V GA + G ++I E L + + D Sbjct: 98 SELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSML 157 Query: 146 -----------KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVK 194 + + L + + +E L SK + +HRD+ NVL+ VK Sbjct: 158 DSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK-NCVHRDLAARNVLLAQGKIVK 216 Query: 195 MCDFGISGYLVDSVAKTIDAGC---KPYMAPERINPELNQKGYSVKSDIWSLGITMIELA 251 +CDFG++ ++ +MAPE I L Y+ SD+WS GI + E+ Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNL----YTTLSDVWSYGILLWEIF 272 Query: 252 I-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 PY ++ + D ++E + +C ++RP++ L Sbjct: 273 SLGGTPYPGMMVDSTFYNKI-KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHL 329 >3TKU-A nrPDB Length = 433 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 122/281 (43%), Gaps = 15/281 (5%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL-LMDLDI 102 + ++ +D E I +GRGA+G V ++ + +I A+K + + + + Sbjct: 83 KEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERD 142 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICME-LMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 + DC + + A E +++ M+ + L + DK +PED+ Sbjct: 143 VLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDK---LPEDMARFYIGE 199 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKPY 219 +V A++ +H +L +HRD+KP NVL++ G +++ DFG + D V ++ G Y Sbjct: 200 MVLAIDSIH-QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDY 258 Query: 220 MAPERINP-ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 ++PE + E Y + D WSLG+ M E+ P+ + K + E Q Sbjct: 259 ISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQF 318 Query: 279 PAD--KFSAEFVDFTSQCLKKNSKERP---TYPELMQHPFF 314 P+ S E D + + + R + +H FF Sbjct: 319 PSHVTDVSEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFF 358 >3OZ6-A nrPDB Length = 388 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 76/343 (22%), Positives = 135/343 (39%), Gaps = 78/343 (22%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDC 109 E + +LG+GAYG+V K +G+++AVK+I A NS + +R ++ I Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGH 68 Query: 110 PFTVTFYGALFREGD--VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 V L + D V++ + M+T L + I + + ++K ++ Sbjct: 69 ENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANI-----LEPVHKQYVVYQLIKVIK 123 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV---------------------- 205 +LHS ++HRD+KPSN+L+NA VK+ DFG+S V Sbjct: 124 YLHS-GGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDD 182 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTP 263 D T + Y APE + L Y+ D+WSLG + E+ + P S Sbjct: 183 DQPILTDYVATRWYRAPEIL---LGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQ 239 Query: 264 FQQLKQVVEEPSPQL------------------------------------------PAD 281 +++ V++ PS + P Sbjct: 240 LERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKA 299 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDV 324 + E +D + L+ N +R + + ++HPF ++ + + Sbjct: 300 DCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEP 342 >4J52-A nrPDB Length = 293 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 62/259 (23%), Positives = 118/259 (45%), Gaps = 13/259 (5%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SMRTVDCPFTVTFYG 117 LG+G + ++ + ++ A K + ++ + +R M ++I R++ V F+G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 V++ +EL + ++ + + + E IV ++LH VIH Sbjct: 82 FFEDNDFVFVVLELCR---RRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN-RVIH 137 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 RD+K N+ +N +VK+ DFG++ + D K + G Y+APE ++ +KG+S Sbjct: 138 RDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLS----KKGHSF 193 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296 + D+WS+G M L + + P+++ L+ E S + + L+ Sbjct: 194 EVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSI---PKHINPVAASLIQKMLQ 250 Query: 297 KNSKERPTYPELMQHPFFT 315 + RPT EL+ FFT Sbjct: 251 TDPTARPTINELLNDEFFT 269 >4IC8-A nrPDB Length = 442 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 81/358 (22%), Positives = 147/358 (41%), Gaps = 51/358 (14%) Query: 1 MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG 60 + + G+ + P +A +S ++L S + F+V D+ E I +G Sbjct: 7 LKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARS-FDVTFDV-GDEYEIIETIG 64 Query: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVN-SQEQKRLLMDLDISMRTVDCPFTVTFYGA- 118 GAYGVV R +GQ +A+K+I + KR L +L I ++ + Sbjct: 65 NGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI-LKHFKHDNIIAIKDIL 123 Query: 119 -----LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 V++ ++LM++ L Q+I Q + + + +++ L+++HS Sbjct: 124 RPTVPYGEFKSVYVVLDLMESDL----HQIIHSSQPLTLEHVRYFLYQLLRGLKYMHS-A 178 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYL-----VDSVAKTIDAGCKPYMAPERINPE 228 VIHRD+KPSN+L+N ++K+ DFG++ L T + Y APE + Sbjct: 179 QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELM--- 235 Query: 229 LNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSP---------- 276 L+ Y+ D+WS+G E+ R FP ++ Q + V+ PSP Sbjct: 236 LSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAER 295 Query: 277 ------------QLPADKFSA----EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 +P + + + + L+ R + ++HPF + Sbjct: 296 VRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYH 353 >1KOA-A nrPDB Length = 491 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 122/280 (43%), Gaps = 16/280 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D + ELG GA+GVV ++ +G A K + T + +++ + ++ +M + P Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV-MTPHESDKETVRKEIQ-TMSVLRHP 108 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V + A + ++ + E M + +++V D+ + ED + + K L H+H Sbjct: 109 TLVNLHDAFEDDNEMVMIYEFMSGG--ELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMH 166 Query: 171 SKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 + +H D+KP N++ ++K+ DFG++ +L + + G + APE Sbjct: 167 EN-NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEV---- 221 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS---A 285 K +D+WS+G+ L P+ G + + V+ + FS Sbjct: 222 AEGKPVGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSCDWNMDDSAFSGISE 279 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVA 325 + DF + L + R T + ++HP+ T + G D Sbjct: 280 DGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQ 319 >5Z33-A nrPDB Length = 425 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 134/325 (41%), Gaps = 47/325 (14%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91 DL + + NQ+F V + ELG+GAYG+V + + + +A+K++ + + Sbjct: 13 DLQGRKIFKVFNQDFIVD-ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKK 71 Query: 92 -EQKRLLMDLDISMRTVDCPFTVTFYGALF----REGDVWICMELMDTSLDKFYKQVIDK 146 KR L ++ + Y + ++ ELM+ L + Sbjct: 72 ILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIR----S 127 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-- 204 GQ + + I+ L+++HS +V+HRD+KP N+L+NA ++K+CDFG++ Sbjct: 128 GQPLTDAHFQSFIYQILCGLKYIHS-ANVLHRDLKPGNLLVNADCELKICDFGLARGFSV 186 Query: 205 ---VDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-- 259 ++ T + Y APE + L+ + Y+ D+WS+G + EL R + Sbjct: 187 DPEENAGYMTEYVATRWYRAPEIM---LSFQSYTKAIDVWSVGCILAELLGGRPFFKGRD 243 Query: 260 -----------WGTPFQQLKQVVEEPS--------PQLPADKFS-------AEFVDFTSQ 293 GTP ++ + P P + F + +D + Sbjct: 244 YVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDR 303 Query: 294 CLKKNSKERPTYPELMQHPFFTLHE 318 L + R + + ++HP+ + Sbjct: 304 MLAFDPSSRISVEQALEHPYLHIWH 328 >2BRG-A nrPDB Length = 297 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 120/274 (43%), Gaps = 11/274 (4%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 +D + + LG GAYG V+ + + + +AVK + + + ++ I+ + ++ Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICIN-KMLNHE 65 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V FYG ++ +E + + ++ + +PE + ++ + +LH Sbjct: 66 NVVKFYGHRREGNIQYLFLEYCSGG--ELFDRI-EPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGIS---GYLVDSVAKTIDAGCKPYMAPERINP 227 + + HRD+KP N+L++ +K+ DFG++ Y G PY+APE + Sbjct: 123 G-IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK- 180 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 ++ ++ D+WS GI + + P+D Q+ E+ + P K + Sbjct: 181 --RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAP 238 Query: 288 VDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 + + L +N R T P++ + ++ KG Sbjct: 239 LALLHKILVENPSARITIPDIKKDRWYNKPLKKG 272 >3HMP-A nrPDB Length = 342 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 64/328 (19%), Positives = 125/328 (38%), Gaps = 24/328 (7%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 + G K K ++ + P + D S N+ VK + ++G G Sbjct: 13 RGSGMKETAAAKFERQHMDSPDLGT-----DDDDKASSSANECISVKGRIYSILKQIGSG 67 Query: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM-DLDISMRTVDC-PFTVTFYGALF 120 V ++ + QI A+K + + ++ + + Y Sbjct: 68 GSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEI 126 Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 + +++ ME + L+ + K K ++I ++++A+ +H ++H D+ Sbjct: 127 TDQYIYMVMECGNIDLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-GIVHSDL 181 Query: 181 KPSNVLINALGQVKMCDFGISGYLVDSVA---KTIDAGCKPYMAPERINPELNQKGYSVK 237 KP+N LI G +K+ DFGI+ + K G YM PE I + + Sbjct: 182 KPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKS 240 Query: 238 S-------DIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 D+WSLG + + + P+ +L +++ D + D Sbjct: 241 KSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDV 300 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHE 318 CLK++ K+R + PEL+ HP+ + Sbjct: 301 LKCCLKRDPKQRISIPELLAHPYVQIQT 328 >2ZMD-A nrPDB Length = 390 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 73/349 (20%), Positives = 137/349 (39%), Gaps = 32/349 (9%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 + G K K ++ + P + D S N+ VK + ++G G Sbjct: 13 RGSGMKETAAAKFERQHMDSPDLGT-----DDDDKASSSANECISVKGRIYSILKQIGSG 67 Query: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM-DLDISMRTVDC-PFTVTFYGALF 120 V ++ + QI A+K + + ++ + + Y Sbjct: 68 GSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEI 126 Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 + +++ ME + L+ + K K ++I ++++A+ +H ++H D+ Sbjct: 127 TDQYIYMVMECGNIDLNSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-GIVHSDL 181 Query: 181 KPSNVLINALGQVKMCDFGISGYLVDSVA---KTIDAGCKPYMAPERINPELNQK----- 232 KP+N LI G +K+ DFGI+ + K G YM PE I + + Sbjct: 182 KPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSSSRENGKS 240 Query: 233 --GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 S KSD+WSLG + + + P+ +L +++ D + D Sbjct: 241 KSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDV 300 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHE------SKGTDVASFVKLILG 333 CLK++ K+R + PEL+ HP+ + +KGT +K +LG Sbjct: 301 LKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT--TEEMKYVLG 347 >5FET-A nrPDB Length = 847 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 125/278 (44%), Gaps = 18/278 (6%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLD 101 Q+ +V+ +LE +GRG +G V+ + H P+ A+K + R+ ++ +Q + ++ + Sbjct: 526 QDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLERE 585 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 I+ D PF + + EL+ + Y + G + + S Sbjct: 586 ITAEN-DHPFIIRLVRTFKDSNCFYFLTELVTGG--ELYDAIRKLG-LLSKPQAQFYLGS 641 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 I+ A+E+LH + ++++RD+KP N+L++ G VK+ DFG + + G YMA Sbjct: 642 IILAIEYLHER-NIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAY--TLVGTPHYMA 698 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 PE I KGY DIW+LG+ + E P+ + ++ + + P Sbjct: 699 PEVI----LGKGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDY 754 Query: 282 KFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 + ++ + L + + R + ++ +H FF Sbjct: 755 VSDQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >2XS0-A nrPDB Length = 386 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 135/337 (40%), Gaps = 60/337 (17%) Query: 27 STPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-R 85 S RD ++ + IG+ F V + + +G GA G+V + +A+K++ R Sbjct: 4 SRSKRD-NNFYSVEIGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSR 61 Query: 86 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKF 139 N KR +L + M+ V+ + DV+I MELMD +L + Sbjct: 62 PFQNQTHAKRAYREL-VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQV 120 Query: 140 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 + +D + + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG Sbjct: 121 IQMELDHER------MSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFG 173 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPY 257 ++ S + Y APE I GY DIWS+G M E+ FP Sbjct: 174 LARTAGTSFMMVPFVVTRYYRAPEVILGM----GYKENVDIWSVGCIMGEMIKGGVLFPG 229 Query: 258 DSWGTPFQQLKQVVEEPSPQ---------------------------LPADKFSAE---- 286 + ++ + + P P+ P F A+ Sbjct: 230 TDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHN 289 Query: 287 ------FVDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 D S+ L ++ +R + E +QHP+ + Sbjct: 290 KLKASQARDLLSKMLVIDASKRISVDEALQHPYINVW 326 >4UYA-A nrPDB Length = 340 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 62/276 (22%), Positives = 110/276 (39%), Gaps = 24/276 (8%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR--ATVNSQEQKRLLMDLDISM 104 V + LE +G G +G V + GQ +AVK R ++ + Sbjct: 22 HVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLF 79 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + P + G ++ + + +E G+ IP +L AV I + Sbjct: 80 AMLRHPNIIELRGVCLQQPHLCLVLEFARGGAL----NRALAGRRIPPHVLVNWAVQIAR 135 Query: 165 ALEHLHSK--LSVIHRDVKPSNVLINA--------LGQVKMCDFGISGYLVDSVAKTIDA 214 + +LH + + ++HRD+K SN+L+ +K+ DFG++ K A Sbjct: 136 GMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-HRTTKMATA 194 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G +MAPE I L +S SDIWS G+ + EL PY V + Sbjct: 195 GAYAWMAPEVIKSSL----FSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKL 250 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + +P+ F +C +++ RP++ +++ Sbjct: 251 TLPIPS-TCPEPFAKLMKECWQQDPHIRPSFALILE 285 >3ZDU-A nrPDB Length = 325 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 123/297 (41%), Gaps = 39/297 (13%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + E + ++G G+YG V K +H +GQI+A+K K + ++ ++ Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIK-FLKQFHH 60 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V ++ + + E +D ++ + + L K I++A+++L Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHG---LESKRLRKYLFQILRAIDYL 117 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPE 228 HS ++IHRD+KP N+L++ G K+CDFG + L + + Y APE + Sbjct: 118 HSN-NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELV--- 173 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE--------------- 273 L Y DIW+LG +IE+A PY + L ++V + Sbjct: 174 LKDTSYGKPVDIWALGCMIIEMATGN-PYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKS 232 Query: 274 --------PSPQLPA------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 P Q P K + D CL+ + +R + +L+ H +FT Sbjct: 233 PIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >1UA2-A nrPDB Length = 346 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 127/298 (42%), Gaps = 40/298 (13%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDISM 104 +A E + LG G + V K R + QI+A+K+I+ S+ + + L ++ + Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK-LL 66 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + P + A + ++ + + M+T L+ K D + + + ++ Sbjct: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMTLQ 123 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPE 223 LE+LH ++HRD+KP+N+L++ G +K+ DFG++ + A T + Y APE Sbjct: 124 GLEYLHQHW-ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE---EPSPQLPA 280 + + Y V D+W++G + EL LR P+ + QL ++ E P+ + Sbjct: 183 LL---FGARMYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 Query: 281 DKFS-----------------------AEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 D S + +D N R T + ++ +F+ Sbjct: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 >1G3N-A nrPDB Length = 326 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 76/303 (25%), Positives = 131/303 (43%), Gaps = 42/303 (13%) Query: 51 DDLEPIMELGRGAYGVVEKMRH-VPSGQIMAVKRIRATVNSQEQK-RLLMDLDI--SMRT 106 E + E+G GAYG V K R G+ +A+KR+R + + ++ + + T Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 107 VDCPFTVTFYGALF-----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 + P V + RE + + E +D L + +V + G +P + + + Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQ 128 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 +++ L+ LHS V+HRD+KP N+L+ + GQ+K+ DFG++ +A T Y A Sbjct: 129 LLRGLDFLHSH-RVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV-------EEP 274 PE L Q Y+ D+WS+G E+ + P + QL +++ EE Sbjct: 188 PEV----LLQSSYATPVDLWSVGCIFAEMFRRK-PLFRGSSDVDQLGKILDVIGLPGEED 242 Query: 275 SPQL--------------PADKFSAEF----VDFTSQCLKKNSKERPTYPELMQHPFFTL 316 P+ P +KF + D +CL N +R + + HP+F Sbjct: 243 WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 Query: 317 HES 319 E Sbjct: 303 LER 305 >1NY3-A nrPDB Length = 400 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 117/283 (41%), Gaps = 27/283 (9%) Query: 51 DDLEP-IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 DD + LG G G V ++ + + + A+K + Q+ + ++++ R C Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 114 Query: 110 PFTVTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVK 164 P V + I ME +D + + ++ D+G Q E +I SI + Sbjct: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGE 172 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 A+++LHS +++ HRDVKP N+L + +K+ DFG + + T Y+A Sbjct: 173 AIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLP 279 PE + PE Y D+WSLG+ M L P+ S +K + + P Sbjct: 232 PEVLGPE----KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Query: 280 ADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 ++ S E LK +R T E M HP+ Sbjct: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 >3SXS-A nrPDB Length = 268 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 120/270 (44%), Gaps = 20/270 (7%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDIS 103 + E+K +++ + ELG G +GVV+ + GQ +AVK I+ S+++ + Sbjct: 2 HMELKREEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSEDE--FFQEAQTM 57 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M+ + P V FYG +E ++I E + + G+ + L ++ + Sbjct: 58 MK-LSHPKLVKFYGVCSKEYPIYIVTEYISNGC--LLNYLRSHGKGLEPSQLLEMCYDVC 114 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYM 220 + + L S IHRD+ N L++ VK+ DFG++ Y++D G K + Sbjct: 115 EGMAFLESH-QFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDD-QYVSSVGTKFPVKWS 172 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 APE + YS KSD+W+ GI M E+ + PYD + LK V + Sbjct: 173 APEV----FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLK--VSQGHRLYR 226 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 S C + ++RPT+ +L+ Sbjct: 227 PHLASDTIYQIMYSCWHELPEKRPTFQQLL 256 >3E7O-A nrPDB Length = 360 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 72/327 (22%), Positives = 127/327 (38%), Gaps = 59/327 (18%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKR 95 + + + F V + + +G GA G+V G +AVK++ R N KR Sbjct: 9 YSVQVADSTFTV-LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 67 Query: 96 LLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKFYKQVIDKGQT 149 +L + ++ V+ ++ DV++ MELMD +L + +D + Sbjct: 68 AYREL-VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHER- 125 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + + ++ ++HLHS +IHRD+KPSN+++ + +K+ DFG++ + Sbjct: 126 -----MSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFM 179 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ 269 T + Y APE I GY DIWS+G M EL + Q K Sbjct: 180 MTPYVVTRYYRAPEVILGM----GYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKV 235 Query: 270 VVEEPSP-----------------------------QLPADKFSAE----------FVDF 290 + + +P P F +E D Sbjct: 236 IEQLGTPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDL 295 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLH 317 S+ L + +R + E ++HP+ T+ Sbjct: 296 LSKMLVIDPDKRISVDEALRHPYITVW 322 >4YNZ-A nrPDB Length = 342 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 116/263 (44%), Gaps = 12/263 (4%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-RLLMDLDISMRTVDCPF 111 LG+G G+V+ H + Q +A+K + S+ ++ ++ I ++ ++ P Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAI-LKLIEHPH 70 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + + + +++ +E + + + ++ KG+ + K I+ AL+ HS Sbjct: 71 VLKLHDVYENKKYLYLVLEHVSGG--ELFDYLVKKGR-LTPKEARKFFRQIISALDFCHS 127 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 S+ HRD+KP N+L++ +++ DFG++ V G Y PE I E Sbjct: 128 H-SICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGE--- 183 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 K K+D+WS G+ + L + P+D +QL + V+ +P + Sbjct: 184 KYDGRKADVWSCGVILFALLVGALPFDD--DNLRQLLEKVKRGVFHMP-HFIPPDCQSLL 240 Query: 292 SQCLKKNSKERPTYPELMQHPFF 314 ++ ++ R T + +H ++ Sbjct: 241 RGMIEVDAARRLTLEHIQKHIWY 263 >3KA0-A nrPDB Length = 320 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 117/283 (41%), Gaps = 27/283 (9%) Query: 51 DDLEP-IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 DD + LG G G V ++ + + + A+K + Q+ + ++++ R C Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 68 Query: 110 PFTVTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVK 164 P V + I ME +D + + ++ D+G Q E +I SI + Sbjct: 69 PHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 A+++LHS +++ HRDVKP N+L + +K+ DFG + + T Y+A Sbjct: 127 AIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVA 185 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLP 279 PE + PE Y D+WSLG+ M L P+ S +K + + P Sbjct: 186 PEVLGPE----KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 241 Query: 280 ADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 ++ S E LK +R T E M HP+ Sbjct: 242 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 284 >2OZA-A nrPDB Length = 356 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 117/283 (41%), Gaps = 27/283 (9%) Query: 51 DDLEP-IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 DD + LG G G V ++ + + + A+K + Q+ + ++++ R C Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 70 Query: 110 PFTVTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVK 164 P V + I ME +D + + ++ D+G Q E +I SI + Sbjct: 71 PHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 A+++LHS +++ HRDVKP N+L + +K+ DFG + + T Y+A Sbjct: 129 AIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 187 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLP 279 PE + PE Y D+WSLG+ M L P+ S +K + + P Sbjct: 188 PEVLGPE----KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 243 Query: 280 ADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 ++ S E LK +R T E M HP+ Sbjct: 244 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 286 >3NYO-A nrPDB Length = 576 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 127/276 (46%), Gaps = 15/276 (5%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL-MDLDISMRT 106 V + LG+G +G V + +G++ A K++ + + + ++ + Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V+ F V+ A + + + + LM+ KF+ + + PE A I L Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGL 299 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 E LH + +++RD+KP N+L++ G +++ D G++ ++ + G YMAPE + Sbjct: 300 EDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF--QQLKQVVEEPSPQLPADKFS 284 E Y+ D W+LG + E+ + P+ ++++++V+E P+ +++FS Sbjct: 359 NE----RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV-PEEYSERFS 413 Query: 285 AEFVDFTSQCLKKNSKERP-----TYPELMQHPFFT 315 + SQ L K+ ER + E+ +HP F Sbjct: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 >4QTB-A nrPDB Length = 380 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 76/303 (25%), Positives = 126/303 (41%), Gaps = 47/303 (15%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 + +G GAYG+V +A+K+I + +R L ++ I +R Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR-FRHEN 100 Query: 112 TVTFYGAL-----FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + L DV+I +LM+T L K K Q + D + I++ L Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLL-----KSQQLSNDHICYFLYQILRGL 155 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG----YLVDSVAKTIDAGCKPYMAP 222 +++HS +V+HRD+KPSN+LIN +K+CDFG++ + T + Y AP Sbjct: 156 KYIHS-ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 214 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGTPFQQ--- 266 E + LN KGY+ DIWS+G + E+ R + G+P Q+ Sbjct: 215 EIM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 271 Query: 267 --LKQVVEEPSPQLPAD----------KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + LP+ K ++ +D + L N +R T E + HP+ Sbjct: 272 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331 Query: 315 TLH 317 + Sbjct: 332 EQY 334 >4C0T-A nrPDB Length = 974 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 115/296 (38%), Gaps = 28/296 (9%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI--RATVNSQEQKRLLMDLDISMRTVD 108 D + ELG G+Y V +G+ AVK + R + ++ K + ++ R + Sbjct: 266 TDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSN 325 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 ++ Y + ++ ++ +I + T+ E+ I+ A+++ Sbjct: 326 RLGVISLYFTFQDKDSLYFVLDYASNGE---LLTLIKRYNTLNEECTRHFGAQILDAIKY 382 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD----------SVAKTIDAGCKP 218 +H VIHRD+KP N+L++ ++++ DFG + L V G Sbjct: 383 MHDN-GVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAE 441 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 Y++PE L K D+W+ G + ++ + P+ T Q + + Sbjct: 442 YVSPEL----LENKYCGKPGDVWAFGCIIYQMIAGKPPFK--ATNEYLTFQKITKLQFAF 495 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 A F D + L R T PE+ +H FF + D F + L D Sbjct: 496 SA-GFPTIIRDLIKKILVLQPSRRATIPEIQKHYFF-----QSVDFKDFDSIWLSD 545 >4MYG-A nrPDB Length = 372 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 126/328 (38%), Gaps = 51/328 (15%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQE 92 + +E+ + P G GAYG V SG+ +A+K++ R + Sbjct: 27 KGFYKQDVNKTAWELPKTYVSPTHV-GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF 85 Query: 93 QKRLLMDLDISMRTVDCPFTVTFYGALFREG------DVWICMELMDTSLDKFYKQVIDK 146 KR +L + ++ + + D ++ M M T L K Sbjct: 86 AKRAYREL-LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM------ 138 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 G E+ + + ++K L+++HS V+HRD+KP N+ +N ++K+ DFG++ + Sbjct: 139 GMEFSEEKIQYLVYQMLKGLKYIHS-AGVVHRDLKPGNLAVNEDCELKILDFGLARHA-- 195 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ 266 T + Y APE I L+ Y+ DIWS+G M E+ + + Q Sbjct: 196 DAEMTGYVVTRWYRAPEVI---LSWMHYNQTVDIWSVGCIMAEMLTGKTLFK-GKDYLDQ 251 Query: 267 LKQVVE----------------------EPSPQLPADKF-------SAEFVDFTSQCLKK 297 L Q+++ + PQ P F S + D + L+ Sbjct: 252 LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLEL 311 Query: 298 NSKERPTYPELMQHPFFTLHESKGTDVA 325 + +R T + + HPFF + Sbjct: 312 DVDKRLTAAQALTHPFFEPFRDPEEETE 339 >4Y93-A nrPDB Length = 446 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 74/281 (26%), Positives = 135/281 (48%), Gaps = 26/281 (9%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI-MAVKRIRATVNSQEQKR 95 + +G ++E+ DL + ELG G +GVV+ + GQ +A+K I+ S+++ Sbjct: 174 STAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSEDE-- 229 Query: 96 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDI 154 ++ M + V YG ++ ++I E M + L + +++ + QT Sbjct: 230 -FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT---QQ 285 Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA 214 L ++ + +A+E+L SK +HRD+ N L+N G VK+ DFG++ Y++D T Sbjct: 286 LLEMCKDVCEAMEYLESK-QFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDD-EYTSST 343 Query: 215 GCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPF--QQLK 268 G K + +PE L +S KSDIW+ G+ M E+ + PY+ + + + Sbjct: 344 GSKFPVKWASPEV----LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 399 Query: 269 QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 Q + P P L +++ C + + ERPT+ L+ Sbjct: 400 QGLRLPRPHLASERV----YAIMYSCWHEKADERPTFKILL 436 >3GC9-A nrPDB Length = 370 Score = 223 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 131/329 (39%), Gaps = 48/329 (14%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNS 90 + +EV L+ + +G GAYG V Q +AVK++ R + Sbjct: 10 PRAGFYRQELNKTVWEVP-QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL 68 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGAL------FREGDVWICMELMDTSLDKFYKQVI 144 +R +L ++ + + +V++ LM L+ Sbjct: 69 IHARRTYRELR-LLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIV---- 123 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 K Q + ++ + + +++ L+++HS +IHRD+KPSNV +N ++++ DFG++ Sbjct: 124 -KSQALSDEHVQFLVYQLLRGLKYIHS-AGIIHRDLKPSNVAVNEDSELRILDFGLARQA 181 Query: 205 VDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGT 262 T + Y APE + LN Y+ DIWS+G M EL + FP + Sbjct: 182 --DEEMTGYVATRWYRAPEIM---LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYID 236 Query: 263 PFQQLKQVVEEPSPQ-------------------LPADKFS-------AEFVDFTSQCLK 296 +++ +VV PSP+ +P S +D + L Sbjct: 237 QLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLV 296 Query: 297 KNSKERPTYPELMQHPFFTLHESKGTDVA 325 +S +R + E + H +F+ + + Sbjct: 297 LDSDQRVSAAEALAHAYFSQYHDPEDEPE 325 >4PDO-A nrPDB Length = 299 Score = 223 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 116/298 (38%), Gaps = 27/298 (9%) Query: 21 EQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHV-PSGQI- 78 + P T P + + E+ + +G G +G V K SG+ Sbjct: 12 QDPHTYEDPNQAVLKFTT--------EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKE 63 Query: 79 --MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSL 136 +A+K ++A +++ L + I M + G + + + I E M+ Sbjct: 64 VPVAIKTLKAGYTEKQRVDFLGEAGI-MGQFSHHNIIRLEGVISKYKPMMIITEYMENGA 122 Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMC 196 + + D L + I +++L + ++ +HRD+ N+L+N+ K+ Sbjct: 123 LDKFLREKDGE--FSVLQLVGMLRGIAAGMKYL-ANMNYVHRDLAARNILVNSNLVCKVS 179 Query: 197 DFGISGYLVDS--VAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIE-LA 251 DFG+S L D T G P + APE I+ + ++ SD+WS GI M E + Sbjct: 180 DFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS----YRKFTSASDVWSFGIVMWEVMT 235 Query: 252 ILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 PY W ++ + + + + QC ++ RP + +++ Sbjct: 236 YGERPY--WELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIV 291 >3V5Q-A nrPDB Length = 297 Score = 223 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 107/284 (37%), Gaps = 31/284 (10%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRH-----VPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 +K D+ ELG GA+G V ++AVK ++ + +K + + Sbjct: 11 HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA-RKDFQREAE 69 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYK------------QVIDKGQ 148 + + V FYG + + E M L+KF + Q Sbjct: 70 -LLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 128 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + + IA I + +L S+ +HRD+ N L+ A VK+ DFG+S + + Sbjct: 129 ELGLSQMLHIASQIASGMVYLASQ-HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTD 187 Query: 209 AKTIDAGC---KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPF 264 + +M PE I + ++ +SD+WS G+ + E+ + P+ Sbjct: 188 YYRVGGHTMLPIRWMPPESI----MYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSN-- 241 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 ++ + + + E D C ++ ++R E+ Sbjct: 242 TEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 285 >4ZSG-A nrPDB Length = 347 Score = 223 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 129/308 (41%), Gaps = 49/308 (15%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN-SQEQKRLLMDLDISMRTVDC 109 D+ E I +G GAYGVV R +GQ +A+K+I + KR L +L I ++ Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI-LKHFKH 65 Query: 110 PFTVTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + V++ ++LM++ L Q+I Q + + + ++ Sbjct: 66 DNIIAIKDILRPTVPYGEFKSVYVVLDLMESDL----HQIIHSSQPLTLEHVRYFLYQLL 121 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-----VDSVAKTIDAGCKP 218 + L+++HS VIHRD+KPSN+L+N ++K+ DFG++ L T + Sbjct: 122 RGLKYMHS-AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILR--FPYDSWGTPFQQLKQVVEEPSP 276 Y APE + L+ Y+ D+WS+G E+ R FP ++ Q + V+ PSP Sbjct: 181 YRAPELM---LSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSP 237 Query: 277 ----------------------QLPADKFSA----EFVDFTSQCLKKNSKERPTYPELMQ 310 +P + + + + L+ R + ++ Sbjct: 238 AVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALR 297 Query: 311 HPFFTLHE 318 HPF + Sbjct: 298 HPFLAKYH 305 >6GVJ-A nrPDB Length = 429 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 125/312 (40%), Gaps = 20/312 (6%) Query: 19 AFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI 78 +Q Q +TP ++L A S N+ VK + ++G G V ++ + QI Sbjct: 113 QQQQHQILATPLQNLQVLAS-SSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQI 170 Query: 79 MAVKRIRATVNSQEQKRLLM-DLDISMRTVDC-PFTVTFYGALFREGDVWICMELMDTSL 136 A+K + + ++ + + Y + +++ ME + L Sbjct: 171 YAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDL 230 Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMC 196 + + K K ++I ++++A+ +H ++H D+KP+N LI G +K+ Sbjct: 231 NSWLK----KKKSIDPWERKSYWKNMLEAVHTIHQH-GIVHSDLKPANFLI-VDGMLKLI 284 Query: 197 DFGISGYLVDSVA---KTIDAGCKPYMAPERINPELNQKGYSVKS-------DIWSLGIT 246 DFGI+ + K G YM PE I + + D+WSLG Sbjct: 285 DFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCI 344 Query: 247 MIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYP 306 + + + P+ +L +++ D + D CLK++ K+R + P Sbjct: 345 LYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIP 404 Query: 307 ELMQHPFFTLHE 318 EL+ HP+ + Sbjct: 405 ELLAHPYVQIQT 416 >3LM0-A nrPDB Length = 327 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 62/296 (20%), Positives = 130/296 (43%), Gaps = 21/296 (7%) Query: 36 KACISIGNQNFEVK-ADDLEPI-----MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN 89 + + +G +N + ++ ELGRG + VV + +GQ A K ++ Sbjct: 8 SSGVDLGTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRR 67 Query: 90 SQE-QKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQ 148 Q+ + +L ++ + CP + + ++ + +E + F + + + Sbjct: 68 GQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGG-EIFSLCLPELAE 126 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLV 205 + E+ + ++ I++ + +LH +++H D+KP N+L+++ LG +K+ DFG+S + Sbjct: 127 MVSENDVIRLIKQILEGVYYLHQN-NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIG 185 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 + G Y+APE LN + +D+W++GI L P+ G Q Sbjct: 186 HACELREIMGTPEYLAPEI----LNYDPITTATDMWNIGIIAYMLLTHTSPF--VGEDNQ 239 Query: 266 QLKQVVEEPSPQLPADKFSAE---FVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 + + + + + FS+ DF L KN ++RPT + H + + Sbjct: 240 ETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 295 >3BBT-B nrPDB Length = 328 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 67/269 (24%), Positives = 120/269 (44%), Gaps = 19/269 (7%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K +L+ + LG GA+G V K VP G+ + A+K + T + + + I Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALI- 70 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M ++D P V G + + +LM + V + I +L V I Sbjct: 71 MASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGC--LLEYVHEHKDNIGSQLLLNWCVQIA 127 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYM 220 K + +L + ++HRD+ NVL+ + VK+ DFG++ L + G K +M Sbjct: 128 KGMMYLEER-RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWM 186 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 A E I + + ++ +SD+WS G+T+ EL PYD G P +++ ++E+ Sbjct: 187 ALECI----HYRKFTHQSDVWSYGVTIWELMTFGGKPYD--GIPTREIPDLLEKGERLPQ 240 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + +C ++ RP + EL Sbjct: 241 PPICTIDVYMVMVKCWMIDADSRPKFKEL 269 >5H2U-A nrPDB Length = 267 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 63/268 (23%), Positives = 114/268 (42%), Gaps = 15/268 (5%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 E ++ +LG G +G V + +A+K I N Q+ L ++ +M+ Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDR-VQVAIKVISRD-NLLHQQMLQSEIQ-AMK 57 Query: 106 TVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + + Y + V+I ELM SL + + +K +P L IA + + Sbjct: 58 KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEK--VLPVSELLDIAWQVAE 115 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP-YMAPE 223 + +L S+ + IHRD+ N+L+ K+ DFG++ + + V + D + APE Sbjct: 116 GMCYLESQ-NYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPE 174 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 L++ YS KSD+WS GI + E+ + PY L+ V+ + Sbjct: 175 ----ALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLR--VDAGYRMPCPLE 228 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQ 310 C ++ ++RPT+ L + Sbjct: 229 CPPSVHKLMLTCWCRDPEQRPTFKALRE 256 >4AW2-A nrPDB Length = 437 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 123/280 (43%), Gaps = 15/280 (5%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL-LMDLDISM 104 + +D E + +GRGA+G V ++ + ++ A+K + + + + + Sbjct: 69 MRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVL 128 Query: 105 RTVDCPFTVTFYGALFREGDVWICMEL-MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 D + T + A + ++++ M+ + L + D+ +PE++ +V Sbjct: 129 VNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR---LPEEMARFYLAEMV 185 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKPYMA 221 A++ +H +L +HRD+KP N+L++ G +++ DFG L++ V ++ G Y++ Sbjct: 186 IAIDSVH-QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 244 Query: 222 PERINPELNQKG-YSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 PE + KG Y + D WSLG+ M E+ P+ + K + + Q P Sbjct: 245 PEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPT 304 Query: 281 D--KFSAEFVDFTSQCLKKNSKERP---TYPELMQHPFFT 315 S D + + + R + +HPFF+ Sbjct: 305 QVTDVSENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFS 343 >5O2C-A nrPDB Length = 380 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 126/280 (45%), Gaps = 15/280 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +ELGRGA+ V K + +A ++ ++ +++ + ++ + P Sbjct: 27 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 86 Query: 113 VTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V FY + + + + ELM + K + + + + +L I+K L+ Sbjct: 87 VRFYDSWESILKGKKCIVLVTELMTSGT---LKTYLKRFKVMKPKVLRSWCRQILKGLQF 143 Query: 169 LHSK-LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 LH++ +IHRD+K N+ I G VK+ D G++ + S AK++ G +MAPE Sbjct: 144 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPE--- 199 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 + ++ Y D+++ G+ M+E+A +PY Q ++V P E Sbjct: 200 --MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPE 257 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 + C+++N ER + +L+ H FF ++A Sbjct: 258 VKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAE 297 >1V0B-A nrPDB Length = 288 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 117/293 (39%), Gaps = 35/293 (11%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + + ++G G YGVV K ++ G+ A+K+IR + + ++ + Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V Y + + + + E +D L K + + ++ + + Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGG---LESVTAKSFLLQLLNGIAYC 116 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPE 228 H + V+HRD+KP N+LIN G++K+ DFG++ + T + Y AP+ + Sbjct: 117 HDR-RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVL--- 172 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVVEEPS----------- 275 + K YS DIWS+G E+ P S ++ +++ P+ Sbjct: 173 MGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELP 232 Query: 276 ---------PQLPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 LP + F +D S+ LK + +R T + ++H +F Sbjct: 233 KYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFK 285 >5NGU-A nrPDB Length = 381 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 127/303 (41%), Gaps = 47/303 (15%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 + +G GAYG+V + +A+K+I + +R L ++ I +R Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLR-FRHEN 101 Query: 112 TVTFYGAL-----FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + + + DV+I +LM+T L K K Q + D + I++ L Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLL-----KTQHLSNDHICYFLYQILRGL 156 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID----AGCKPYMAP 222 +++HS +V+HRD+KPSN+L+N +K+CDFG++ T + Y AP Sbjct: 157 KYIHS-ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 215 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVVEEPSPQ--- 277 E + LN KGY+ DIWS+G + E+ R P + + ++ PS + Sbjct: 216 EIM---LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 272 Query: 278 -------------------LPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 +P ++ ++ +D + L N +R + + HP+ Sbjct: 273 CIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 Query: 315 TLH 317 + Sbjct: 333 EQY 335 >5O2B-A nrPDB Length = 285 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 123/269 (45%), Gaps = 15/269 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +ELGRGA+ V K + +A ++ ++ +++ + ++ + P Sbjct: 18 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 77 Query: 113 VTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V FY + + + + ELM + K + + + + +L I+K L+ Sbjct: 78 VRFYDSWESILKGKKCIVLVTELMTSGT---LKTYLKRFKVMKPKVLRSWCRQILKGLQF 134 Query: 169 LHSK-LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 LH++ +IHRD+K N+ I G VK+ D G++ + S AK++ G +MAPE Sbjct: 135 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPE--- 190 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 + ++ Y D+++ G+ M+E+A +PY Q ++V P E Sbjct: 191 --MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPE 248 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + C+++N ER + +L+ H FF Sbjct: 249 VKEIIEGCIRQNKSERLSIRDLLNHAFFA 277 >4WNO-A nrPDB Length = 287 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 117/281 (41%), Gaps = 24/281 (8%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVP-SGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 FE DL +G GA+ VV K RH +AVK I ++ Q L ++ I Sbjct: 17 KFEFSRKDL-----IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKI- 70 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 ++ + V Y V++ ME + + +T+ ED + I Sbjct: 71 LKELKHENIVALYDFQEMANSVYLVMEYCNGGD---LADYLHAMRTLSEDTIRLFLQQIA 127 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALG---------QVKMCDFGISGYLVDSVAKTIDA 214 A+ LHSK +IHRD+KP N+L++ +VK+ DFG + YL ++ Sbjct: 128 GAMRLLHSK-GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLC 186 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G YMAPE I + Y K+D+WS+G + + + P+ + +L + Sbjct: 187 GSPMYMAPEVI----MSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT 242 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + SA L++N K+R + E HPF Sbjct: 243 LVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLD 283 >5LOH-A nrPDB Length = 341 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 120/276 (43%), Gaps = 24/276 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMDLDISMRTVD 108 ++ + + RGA+G V + G++ AVK ++ +N ++ + D ++ Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERD-ALALSK 92 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 PF V Y +L +V++ ME + K + E++ K + AL++ Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYG---YFDEEMAVKYISEVALALDY 149 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-------YLVDSVAKTIDAGCKPYMA 221 LH +IHRD+KP N+LI+ G +K+ DFG+S ++D + G Y+A Sbjct: 150 LHRH-GIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLA 208 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-- 279 PE L + + D W+LG+ + E P++ QQ+ Q + + P Sbjct: 209 PEL----LLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETP--QQVFQNILKRDIPWPEG 262 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +K S L + +R EL +HP F+ Sbjct: 263 EEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFS 298 >4AF3-A nrPDB Length = 292 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 130/289 (44%), Gaps = 17/289 (5%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE- 92 +S I ++F + DD E LG+G +G V R S I+A+K + + +E Sbjct: 8 NSSGTPDILTRHFTI--DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG 65 Query: 93 -QKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 + +L +++I + P + Y + +++ +E + YK+ + K T Sbjct: 66 VEHQLRREIEIQAH-LHHPNILRLYNYFYDRRRIYLILEYAPRG--ELYKE-LQKSCTFD 121 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 E I + AL + H K VIHRD+KP N+L+ G++K+ DFG S + S+ + Sbjct: 122 EQRTATIMEELADALMYCHGK-KVIHRDIKPENLLLGLKGELKIADFGWSVH-APSLRRK 179 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G Y+ PE I + ++ K D+W +G+ EL + P++S + + + Sbjct: 180 TMCGTLDYLPPEMIEGRM----HNEKVDLWCIGVLCYELLVGNPPFESASHN--ETYRRI 233 Query: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 + + PA D S+ L+ N ER ++ HP+ + + Sbjct: 234 VKVDLKFPA-SVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRR 281 >1KOB-A nrPDB Length = 387 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 130/319 (40%), Gaps = 26/319 (8%) Query: 2 SQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGR 61 S+ +GK P + + +E P + + D + + ELG Sbjct: 12 SKVRGKYDGPKINDYDKFYEDIWKKYVPQPVEVKQGSV----------YDYYDILEELGS 61 Query: 62 GAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR 121 GA+GVV + +G++ K I T ++ + ++ I M + P + + A Sbjct: 62 GAFGVVHRCVEKATGRVFVAKFIN-TPYPLDKYTVKNEISI-MNQLHHPKLINLHDAFED 119 Query: 122 EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181 + ++ + +E + + + ++ + + E + + L+H+H S++H D+K Sbjct: 120 KYEMVLILEFLSGG--ELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH-SIVHLDIK 176 Query: 182 PSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSD 239 P N++ VK+ DFG++ L + + APE ++ E +D Sbjct: 177 PENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVDRE----PVGFYTD 232 Query: 240 IWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS---AEFVDFTSQCLK 296 +W++G+ L P+ G + Q V+ + D FS E DF L+ Sbjct: 233 MWAIGVLGYVLLSGLSPFA--GEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQ 290 Query: 297 KNSKERPTYPELMQHPFFT 315 K ++R T + ++HP+ Sbjct: 291 KEPRKRLTVHDALEHPWLK 309 >3C51-A nrPDB Length = 543 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 76/273 (27%), Positives = 130/273 (47%), Gaps = 18/273 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVDCP 110 LGRG +G V + +G++ A K++ + + + +++ I + V Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKI-LAKVHSR 245 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK-GQTIPEDILGKIAVSIVKALEHL 169 F V+ A + D+ + M +M+ +++ +D+ E IV LEHL Sbjct: 246 FIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHL 305 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI-DAGCKPYMAPERINPE 228 H + ++I+RD+KP NVL++ G V++ D G++ L KT AG +MAPE + E Sbjct: 306 HQR-NIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGE 364 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ--QLKQVVEEPSPQLPADKFSAE 286 Y D ++LG+T+ E+ R P+ + G + +LKQ V E + P DKFS Sbjct: 365 E----YDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYP-DKFSPA 419 Query: 287 FVDFTSQCLKKNSKERPTYPE-----LMQHPFF 314 DF L+K+ ++R + + L HP F Sbjct: 420 SKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLF 452 >3KN6-A nrPDB Length = 325 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 118/289 (40%), Gaps = 30/289 (10%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 S Q++++ D LG G++ + K H S Q AVK I + + QK + Sbjct: 4 SPFYQHYDLDLKD----KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEIT-- 57 Query: 100 LDISMRTVD-CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 +++ + P V + + ++ MEL++ + ++++ K + E I Sbjct: 58 ---ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGG--ELFERI-KKKKHFSETEASYI 111 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLI---NALGQVKMCDFGISGYLV-DSVAKTIDA 214 +V A+ H+H + V+HRD+KP N+L N ++K+ DFG + D+ Sbjct: 112 MRKLVSAVSHMHD-VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC 170 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ-----QLKQ 269 Y APE LNQ GY D+WSLG+ + + + P+ S ++ + Sbjct: 171 FTLHYAAPEL----LNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK 226 Query: 270 VVEEPSPQLP---ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +++ S E D L + +R L + + Sbjct: 227 KIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQ 275 >5EFQ-A nrPDB Length = 347 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 121/309 (39%), Gaps = 58/309 (18%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE-QKRLLMDLDISMRTVDC 109 D + I +G G YG V K R +G+++A+K++R + + ++ I +R + Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI-LRQLTH 69 Query: 110 PFTVTFYGALFREGD----------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + + + D ++ E MD L + + E+ + Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGL---VHFNENHIKSFM 126 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDAGCK 217 +++ L++ H K + +HRD+K SN+L+N GQ+K+ DFG++ +S T Sbjct: 127 RQLMEGLDYCH-KKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITL 185 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF---------------------- 255 Y PE + L ++ Y+ D+WS G + EL + Sbjct: 186 WYRPPELL---LGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 242 Query: 256 ----------PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 PY + P +Q ++ + E +P A +D L + +R T Sbjct: 243 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIP-----AAALDLFDYMLALDPSKRCTA 297 Query: 306 PELMQHPFF 314 + +Q F Sbjct: 298 EQALQCEFL 306 >4OLI-A nrPDB Length = 645 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 35/285 (12%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDIS 103 L+ I +LG G +G V + P+ G+++AVK ++A Q + ++DI Sbjct: 350 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDI- 408 Query: 104 MRTVDCPFTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAV 160 +RT+ + + G +G+ + + ME + SL + + +I L A Sbjct: 409 LRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPR-----HSIGLAQLLLFAQ 463 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCKP 218 I + + +LHS+ IHR++ NVL++ VK+ DFG++ + + G P Sbjct: 464 QICEGMAYLHSQ-HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 522 Query: 219 --YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV------ 270 + APE L + + SD+WS G+T+ EL S T F +L + Sbjct: 523 VFWYAPEC----LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 578 Query: 271 -------VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +E DK E C + + RPT+ L Sbjct: 579 VLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 94/250 (37%), Gaps = 22/250 (8%) Query: 70 MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICM 129 R + +K + + + + + M V +G R + + Sbjct: 88 GRDRGQELRVVLKVLDPSHH--DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 145 Query: 130 ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189 E ++ + + + +P +A + AL +L +K +++H +V N+L+ Sbjct: 146 EYVEHGPLDVWLR--RERGHVPMAWKMVVAQQLASALSYLENK-NLVHGNVCGRNILLAR 202 Query: 190 LGQ-------VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWS 242 LG +K+ D G+ + ++++ P++APE + N S D W Sbjct: 203 LGLAEGTSPFIKLSDPGVG---LGALSREERVERIPWLAPECLPGGANS--LSTAMDKWG 257 Query: 243 LGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKE 301 G T++E+ P S ++ + +LP TSQCL + Sbjct: 258 FGATLLEICFDGEAPLQSRSPSEKEHFY---QRQHRLPEPSCPQ-LATLTSQCLTYEPTQ 313 Query: 302 RPTYPELMQH 311 RP++ +++ Sbjct: 314 RPSFRTILRD 323 >3QGY-A nrPDB Length = 286 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 55/278 (19%), Positives = 118/278 (42%), Gaps = 18/278 (6%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL 96 + G+ + + +L + E+G G +G+V + +A+K I+ S++ Sbjct: 13 GLVPRGSLHMVIDPSELTFVQEIGSGQFGLVHLGYW-LNKDKVAIKTIKEGSMSED--DF 69 Query: 97 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 + + ++ M+ + P V YG + + + E M+ + + + L Sbjct: 70 IEEAEVMMK-LSHPKLVQLYGVCLEQAPICLVFEFMEHGCLS--DYLRTQRGLFAAETLL 126 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216 + + + + + +L VIHRD+ N L+ +K+ DFG++ +++D T G Sbjct: 127 GMCLDVCEGMAYLEEAC-VIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD-QYTSSTGT 184 Query: 217 K---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVE 272 K + +PE + YS KSD+WS G+ M E+ + PY++ ++ + + Sbjct: 185 KFPVKWASPEVFS----FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNS--EVVEDIS 238 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 S + C K+ ++RP + L++ Sbjct: 239 TGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLR 276 >6BSD-A nrPDB Length = 876 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 117/326 (35%), Gaps = 60/326 (18%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR--------------HVPSGQ--IMA 80 + G + L +LG G +G V +V G ++A Sbjct: 557 GAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVA 616 Query: 81 VKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKF 139 VK +R + L ++ I R D P + G ++ + + + M+ L++F Sbjct: 617 VKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLGVCVQDDPLCMITDYMENGDLNQF 675 Query: 140 Y--KQVIDK-------------GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 Q+ DK G TI +L +A I + +L + L+ +HRD+ N Sbjct: 676 LSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRN 734 Query: 185 VLINALGQVKMCDFGISGYLVDSVAKTIDAGC---KPYMAPERINPELNQKGYSVKSDIW 241 L+ +K+ DFG+S L + +MA E I ++ SD+W Sbjct: 735 CLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECI----LMGKFTTASDVW 790 Query: 242 SLGITMIE--LAILRFPYDSWGTPFQQLKQVVEEPSPQL----------PADKFSAEFVD 289 + G+T+ E + P+ +QV+E + Sbjct: 791 AFGVTLWEVLMLCRAQPFGQLTD-----EQVIENAGEFFRDQGRQVYLSRPPACPQGLYE 845 Query: 290 FTSQCLKKNSKERPTYPELMQHPFFT 315 +C + S++RP + +L H F Sbjct: 846 LMLRCWSRESEQRPPFSQL--HRFLA 869 >6FEX-A nrPDB Length = 321 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 116/320 (36%), Gaps = 54/320 (16%) Query: 37 ACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMR--------------HVPSGQ--IMA 80 + G + L +LG G +G V +V G ++A Sbjct: 2 GAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVA 61 Query: 81 VKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKF 139 VK +R + L ++ I R D P + G ++ + + + M+ L++F Sbjct: 62 VKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLGVCVQDDPLCMITDYMENGDLNQF 120 Query: 140 Y--KQVIDKG-------QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL 190 Q+ DK TI +L +A I + +L + L+ +HRD+ N L+ Sbjct: 121 LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYL-ATLNFVHRDLATRNCLVGEN 179 Query: 191 GQVKMCDFGISGYLVDSVAKTIDAGC---KPYMAPERINPELNQKGYSVKSDIWSLGITM 247 +K+ DFG+S L + +MA E I ++ SD+W+ G+T+ Sbjct: 180 FTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECI----LMGKFTTASDVWAFGVTL 235 Query: 248 IE--LAILRFPYDSWGTPFQQLKQVVEEPSPQL----------PADKFSAEFVDFTSQCL 295 E + P+ +QV+E + +C Sbjct: 236 WEVLMLCRAQPFGQLTD-----EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCW 290 Query: 296 KKNSKERPTYPELMQHPFFT 315 + S++RP + +L H F Sbjct: 291 SRESEQRPPFSQL--HRFLA 308 >1K9A-A nrPDB Length = 450 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 68/273 (24%), Positives = 119/273 (43%), Gaps = 24/273 (8%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 + + +L+ + +G+G +G V + G +AVK I+ +Q L + + Sbjct: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ---AFLAEASV 239 Query: 103 SMRTVDCPFTVTFYGAL-FREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAV 160 M + V G + +G ++I E M SL + + + D L K ++ Sbjct: 240 -MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS--RGRSVLGGDCLLKFSL 296 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP-- 218 + +A+E+L + +HRD+ NVL++ K+ DFG++ + T D G P Sbjct: 297 DVCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVK 351 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQ 277 + APE L +K +S KSD+WS GI + E+ R PY P + + VE+ Sbjct: 352 WTAPE----ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKM 405 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 D D C ++ RPT+ +L + Sbjct: 406 DAPDGCPPAVYDVMKNCWHLDAATRPTFLQLRE 438 >5YV8-A nrPDB Length = 298 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 130/299 (43%), Gaps = 40/299 (13%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ-------------- 93 V+ + E+G+G+YGVV+ + A+K + ++ Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 94 -----------KRLLMDLDISMRTVDCPFTVTFYGALFR--EGDVWICMELMDTSLDKFY 140 +++ ++ I ++ +D P V L E +++ EL++ Sbjct: 70 PGGCIQPRGPIEQVYQEIAI-LKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV--- 125 Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI 200 + + + ED ++K +E+LH + +IHRD+KPSN+L+ G +K+ DFG+ Sbjct: 126 -MEVPTLKPLSEDQARFYFQDLIKGIEYLHYQ-KIIHRDIKPSNLLVGEDGHIKIADFGV 183 Query: 201 SGYLVDSVA-KTIDAGCKPYMAPERINPELNQKGYSVKS-DIWSLGITMIELAILRFPYD 258 S S A + G +MAPE ++ +K +S K+ D+W++G+T+ + P+ Sbjct: 184 SNEFKGSDALLSNTVGTPAFMAPESLSE--TRKIFSGKALDVWAMGVTLYCFVFGQCPF- 240 Query: 259 SWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 L ++ + + P + + D ++ L KN + R PE+ HP+ T Sbjct: 241 -MDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >4B8L-A nrPDB Length = 286 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 64/276 (23%), Positives = 119/276 (43%), Gaps = 15/276 (5%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE--QKRLLMDLDISM 104 + DD + LG+G +G V R + IMA+K + + +E + +L +++I Sbjct: 11 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQS 70 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + P + Y +++ +E + YK++ G+ E + Sbjct: 71 H-LRHPNILRMYNYFHDRKRIYLMLEFAPRG--ELYKELQKHGR-FDEQRSATFMEELAD 126 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 AL + H + VIHRD+KP N+L+ G++K+ DFG S + S+ + G Y+ PE Sbjct: 127 ALHYCHER-KVIHRDIKPENLLMGYKGELKIADFGWSVH-APSLRRRTMCGTLDYLPPEM 184 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 I K + K D+W G+ E + P+DS + + + + P S Sbjct: 185 IEG----KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSH--TETHRRIVNVDLKFPP-FLS 237 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 D S+ L+ + +R +M+HP+ + + Sbjct: 238 DGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRR 273 >4TNB-A nrPDB Length = 590 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 63/275 (22%), Positives = 124/275 (45%), Gaps = 15/275 (5%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRT 106 V + LG+G +G V + +G++ A KR+ + + ++ + + ++ + Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V+ F V A + + + + +M+ KF+ + E+ A I+ L Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNM-GNPGFEEERALFYAAEILCGL 299 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 E LH + + ++RD+KP N+L++ G +++ D G++ + + G YMAPE Sbjct: 300 EDLHHE-NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEV-- 356 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF--QQLKQVVEEPSPQLPADKFS 284 LN + Y + D W LG + E+ + P+ +++ + V E ++ + KFS Sbjct: 357 --LNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE-EVYSHKFS 413 Query: 285 AEFVDFTSQCLKKNSKERPT-----YPELMQHPFF 314 E L K++K+R E+ +HPFF Sbjct: 414 EEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFF 448 >3ORZ-A nrPDB Length = 316 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 121/301 (40%), Gaps = 23/301 (7%) Query: 25 TSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI 84 T++ P S Q + + +D + LG G++ V R + + + A+K + Sbjct: 11 TAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKIL 70 Query: 85 --RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQ 142 R + + + + D+ M +D PF V Y + ++ + + K Sbjct: 71 EKRHIIKENKVPYVTRERDV-MSRLDHPFFVKLYFCFQDDEKLYFGLSYAKNG--ELLKY 127 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + G + E IV ALE+LH K +IHRD+KP N+L+N +++ DFG + Sbjct: 128 IRKIG-SFDETCTRFYTAEIVSALEYLHGK-GIIHRDLKPENILLNEDMHIQITDFGTAK 185 Query: 203 YLVDSVAK---TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 L + G Y++PE L +K SD+W+LG + +L P+ + Sbjct: 186 VLSPESKQARANSFVGTAQYVSPEL----LTEKSACKSSDLWALGCIIYQLVAGLPPFRA 241 Query: 260 WGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPE------LMQHPF 313 + Q + + P F D + L ++ +R E L HPF Sbjct: 242 GNE--YLIFQKIIKLEYDFPEKFFPK-ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPF 298 Query: 314 F 314 F Sbjct: 299 F 299 >3LZB-A nrPDB Length = 327 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 116/269 (43%), Gaps = 19/269 (7%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K + + I LG GA+G V K +P G+ + A+K +R + + K +L + + Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV- 70 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M +VD P G V + +LM V + I L V I Sbjct: 71 MASVDNPHVCRLLGICLTST-VQLITQLMPFGC--LLDYVREHKDNIGSQYLLNWCVQIA 127 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYM 220 K + +L + ++HRD+ NVL+ VK+ DFG++ L + G K +M Sbjct: 128 KGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 186 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 A E I + Y+ +SD+WS G+T+ EL PYD G P ++ ++E+ Sbjct: 187 ALESI----LHRIYTHQSDVWSYGVTVWELMTFGSKPYD--GIPASEISSILEKGERLPQ 240 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + +C ++ RP + EL Sbjct: 241 PPICTIDVYMIMRKCWMIDADSRPKFREL 269 >1LUF-A nrPDB Length = 343 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 110/291 (37%), Gaps = 42/291 (14%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSG-------QIMAVKRIRATVNSQEQKRLLMD 99 E +++E + ++G GA+G V + R G ++AVK ++ ++ Q + Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFTMVAVKMLKEEASADMQADFQRE 100 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKG----------- 147 M D P V G + + E M L++F + + Sbjct: 101 AA-LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLST 159 Query: 148 ---------QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 + IA + + +L S+ +HRD+ N L+ VK+ DF Sbjct: 160 RARVSSPGPPPLSCAEQLCIARQVAAGMAYL-SERKFVHRDLATRNCLVGENMVVKIADF 218 Query: 199 GISGYLVDSVAKT---IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA-ILR 254 G+S + + DA +M PE I Y+ +SD+W+ G+ + E+ Sbjct: 219 GLSRNIYSADYYKADGNDAIPIRWMPPESI----FYNRYTTESDVWAYGVVLWEIFSYGL 274 Query: 255 FPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 PY +G +++ V + + + E + C K +RP++ Sbjct: 275 QPY--YGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSF 323 >5GNK-A nrPDB Length = 297 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 70/269 (26%), Positives = 117/269 (43%), Gaps = 19/269 (7%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K + + I LG GA+G V K +P G+ + A+K +R + + K +L + + Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV- 74 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M +VD P G V + M+LM V + I L V I Sbjct: 75 MASVDNPHVCRLLGICLTST-VQLIMQLMPFGC--LLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK---PYM 220 K + +L + ++HRD+ NVL+ VK+ DFG++ L + G K +M Sbjct: 132 KGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWM 190 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 A E I + Y+ +SD+WS G+T+ EL PYD G P ++ ++E+ Sbjct: 191 ALESI----LHRIYTHQSDVWSYGVTVWELMTFGSKPYD--GIPASEISSILEKGERLPQ 244 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + +C ++ RP + EL Sbjct: 245 PPICTIDVYMIMVKCWMIDADSRPKFREL 273 >4BGQ-A nrPDB Length = 304 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 126/299 (42%), Gaps = 39/299 (13%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + E + +G GAYGVV K RH + +I+A+K+ + + ++E K + +RT+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 V A R G +++ E ++ ++ + +++ + +P + + ++KA+ Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWC 127 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID--AGCKPYMAPERINP 227 H K ++HRD+KP N+LI+ +K+CDFG + L + D + Y +PE + Sbjct: 128 H-KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT--------------PFQQLKQVVEE 273 Y D+WS+G + EL+ + + P +Q+K Sbjct: 187 A----PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN 242 Query: 274 PSP---QLPADKFS------------AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLH 317 P + PA + +D LK + +R + + HP F Sbjct: 243 PRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 301 >4NST-A nrPDB Length = 351 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 121/310 (39%), Gaps = 58/310 (18%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE-QKRLLMDLDISMRTVDC 109 D + I +G G YG V K + +G+++A+K++R + + ++ I +R + Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI-LRQLIH 71 Query: 110 PFTVTFYGALFREGD----------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 V + + D ++ E MD L + + ED + Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGL---VHFSEDHIKSFM 128 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL--VDSVAKTIDAGCK 217 +++ LE+ H K + +HRD+K SN+L+N GQ+K+ DFG++ +S T Sbjct: 129 KQLMEGLEYCH-KKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITL 187 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF---------------------- 255 Y PE + L ++ Y+ D+WS G + EL + Sbjct: 188 WYRPPELL---LGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 244 Query: 256 ----------PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 PY + P +Q ++ + E +P + +D L + +R T Sbjct: 245 PAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIP-----SAALDLLDHMLTLDPSKRCTA 299 Query: 306 PELMQHPFFT 315 + +Q F Sbjct: 300 EQTLQSDFLK 309 >3PP0-A nrPDB Length = 338 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 68/270 (25%), Positives = 121/270 (44%), Gaps = 19/270 (7%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K +L + LG GA+G V K +P G+ + A+K +R + + K +L + + Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYV- 72 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 M V P+ G V + +LM V + + L + I Sbjct: 73 MAGVGSPYVSRLLGICLTST-VQLVTQLMPYGC--LLDHVRENRGRLGSQDLLNWCMQIA 129 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKP--YM 220 K + +L + ++HRD+ NVL+ + VK+ DFG++ L D D G P +M Sbjct: 130 KGMSYLED-VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWM 188 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 A E I ++ ++ +SD+WS G+T+ EL PYD G P +++ ++E+ Sbjct: 189 ALESI----LRRRFTHQSDVWSYGVTVWELMTFGAKPYD--GIPAREIPDLLEKGERLPQ 242 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + +C +S+ RP + EL+ Sbjct: 243 PPICTIDVYMIMVKCWMIDSECRPRFRELV 272 >3I81-A nrPDB Length = 315 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 115/280 (41%), Gaps = 24/280 (8%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHV-----PSGQIMAVKRIRATVNSQEQKRLLMD 99 +EV + + ELG+G++G+V + +A+K + + +E+ L + Sbjct: 12 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 71 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL---- 155 + M+ +C V G + + + MELM K Y + + + Sbjct: 72 ASV-MKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 130 Query: 156 ---GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212 ++A I + +L++ +HRD+ N ++ VK+ DFG++ + ++ Sbjct: 131 SKMIQMAGEIADGMAYLNAN-KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRK 189 Query: 213 DAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLK 268 +M+PE + + ++ SD+WS G+ + E+A L PY +Q+ Sbjct: 190 GGKGLLPVRWMSPESLKDGV----FTTYSDVWSFGVVLWEIATLAEQPYQGLSN--EQVL 243 Query: 269 QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + V E D + C + N K RP++ E+ Sbjct: 244 RFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >6DBM-A nrPDB Length = 318 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 118/285 (41%), Gaps = 35/285 (12%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDIS 103 L+ I +LG G +G V + P+ G+++AVK ++A Q + ++DI Sbjct: 28 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDI- 86 Query: 104 MRTVDCPFTVTFYGALFREG--DVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAV 160 +RT+ + + G G + + ME + SL + + +I L A Sbjct: 87 LRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPR-----HSIGLAQLLLFAQ 141 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCKP 218 I + + +LHS+ IHRD+ NVL++ VK+ DFG++ + + G P Sbjct: 142 QICEGMAYLHSQ-HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 200 Query: 219 --YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV------ 270 + APE L + + SD+WS G+T+ EL S T F +L + Sbjct: 201 VFWYAPEC----LKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 256 Query: 271 -------VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +E DK AE C + + RPT+ L Sbjct: 257 VLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >5UUU-A nrPDB Length = 547 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 123/280 (43%), Gaps = 19/280 (6%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 103 N + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 192 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 251 Query: 104 MRTV---DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + V DCPF V A + ++LM+ + + E + A Sbjct: 252 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGD---LHYHLSQHGVFSEADMRFYAA 308 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ G YM Sbjct: 309 EIILGLEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYM 366 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF-QQLKQVVEEPSPQLP 279 APE + + Y +D +SLG + +L P+ T ++ ++ + +LP Sbjct: 367 APEVLQKGVA---YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 423 Query: 280 ADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 D FS E L+++ R E+ + PFF Sbjct: 424 -DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 462 >4PWN-A nrPDB Length = 274 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 118/269 (43%), Gaps = 14/269 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 L+ +E+GRG++ V K + +A ++ ++ +++ + ++ + P Sbjct: 12 LKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNI 71 Query: 113 VTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V FY + + + + ELM + K + + + + +L I+K L+ Sbjct: 72 VRFYDSWESTVKGKKCIVLVTELMTSGT---LKTYLKRFKVMKIKVLRSWCRQILKGLQF 128 Query: 169 LHSK-LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 LH++ +IHRD+K N+ I G VK+ D G++ + G +MAPE Sbjct: 129 LHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE--- 185 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 + ++ Y D+++ G+ M+E+A +PY Q ++V P E Sbjct: 186 --MYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPE 243 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + C+++N ER + +L+ H FF Sbjct: 244 VKEIIEGCIRQNKDERYSIKDLLNHAFFQ 272 >2HW6-A nrPDB Length = 307 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 116/287 (40%), Gaps = 33/287 (11%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 LG GAY V+ + +G+ AVK I + R+ +++ + + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAG-HSRSRVFREVETLYQCQGNKNILELI 77 Query: 117 GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVI 176 + ++ E + I K + E ++ + AL+ LH+K + Sbjct: 78 EFFEDDTRFYLVFEKLQGG---SILAHIQKQKHFNEREASRVVRDVAAALDFLHTK-GIA 133 Query: 177 HRDVKPSNVLINAL---GQVKMCDFGI--------SGYLVDSVAKTIDAGCKPYMAPERI 225 HRD+KP N+L + VK+CDF + S + + T G YMAPE + Sbjct: 134 HRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVV 193 Query: 226 NPELNQ-KGYSVKSDIWSLGITMIELAILRFPYDSWGTPF-------------QQLKQVV 271 +Q Y + D+WSLG+ + + P+ +L + + Sbjct: 194 EVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESI 253 Query: 272 EEPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +E + P + S+E D S+ L +++K+R + +++QHP+ Sbjct: 254 QEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >1BYG-A nrPDB Length = 278 Score = 217 bits (552), Expect = 6e-57, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 123/284 (43%), Gaps = 29/284 (10%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 + + +L+ + +G+G +G V + G +AVK I+ +Q L + + Sbjct: 13 RSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQ---AFLAEASV 67 Query: 103 SMRTVDCPFTVTFYGAL-FREGDVWICMELM-DTSLDKFYKQVIDKGQTIPEDILGKIAV 160 M + V G + +G ++I E M SL + + + D L K ++ Sbjct: 68 -MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS--RGRSVLGGDCLLKFSL 124 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP-- 218 + +A+E+L + +HRD+ NVL++ K+ DFG++ + T D G P Sbjct: 125 DVCEAMEYLEGN-NFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVK 179 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQ 277 + APE L +K +S KSD+WS GI + E+ R PY P + + VE+ Sbjct: 180 WTAPE----ALREKKFSTKSDVWSFGILLWEIYSFGRVPYPR--IPLKDVVPRVEKGYKM 233 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPEL---MQHPFFTLHE 318 D + C ++ RP++ +L ++H HE Sbjct: 234 DAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH--IKTHE 275 >2OZO-A nrPDB Length = 613 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 133/326 (40%), Gaps = 27/326 (8%) Query: 10 NPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFE-----VKADDLEPIM-ELGRGA 63 + G P P D + + +K D+L ELG G Sbjct: 289 SDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGN 348 Query: 64 YGVVEKMRHVPSGQI--MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR 121 +G V + + + +A+K ++ + + ++ + I M +D P+ V G Sbjct: 349 FGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVRLIGVCQA 407 Query: 122 EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181 E + + ME+ +K ++ K + IP + ++ + +++L K + +HR++ Sbjct: 408 EA-LMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK-NFVHRNLA 463 Query: 182 PSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKP---YMAPERINPELNQKGYSVK 237 NVL+ K+ DFG+S L D T + K + APE I N + +S + Sbjct: 464 ARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI----NFRKFSSR 519 Query: 238 SDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296 SD+WS G+TM E L+ + PY P ++ +E+ + E S C Sbjct: 520 SDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECPPECPPELYALMSDCWI 577 Query: 297 KNSKERPTY---PELMQHPFFTLHES 319 ++RP + + M+ +++L Sbjct: 578 YKWEDRPDFLTVEQRMRACYYSLASK 603 >4AT3-A nrPDB Length = 299 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 107/275 (38%), Gaps = 28/275 (10%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVP-----SGQIMAVKRIRATVNSQEQKRLLMDLD 101 +K ++ ELG GA+G V ++AVK ++ + +K + + Sbjct: 9 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAE 67 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQ------VIDKGQT---IP 151 + + V FYG + + E M L+KF + ++ +G + Sbjct: 68 -LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 126 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 + + IA I + +L S+ +HRD+ N L+ VK+ DFG+S + + Sbjct: 127 QSQMLHIAQQIAAGMVYLASQ-HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYR 185 Query: 212 IDAGC---KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQL 267 + +M PE I + ++ +SD+WSLG+ + E+ + P+ ++ Sbjct: 186 VGGHTMLPIRWMPPESI----MYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN--EV 239 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKER 302 + + + E + C ++ R Sbjct: 240 IECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 274 >3PVW-A nrPDB Length = 695 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 123/280 (43%), Gaps = 19/280 (6%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDIS 103 N + +D +GRG +G V R +G++ A+K + + + ++ + L ++ I Sbjct: 183 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 242 Query: 104 MRTV---DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + V DCPF V A + ++LM+ + + E + A Sbjct: 243 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGD---LHYHLSQHGVFSEADMRFYAA 299 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYM 220 I+ LEH+H++ V++RD+KP+N+L++ G V++ D G++ G YM Sbjct: 300 EIILGLEHMHNRF-VVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYM 357 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF-QQLKQVVEEPSPQLP 279 APE + + Y +D +SLG + +L P+ T ++ ++ + +LP Sbjct: 358 APEVLQKGVA---YDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELP 414 Query: 280 ADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 D FS E L+++ R E+ + PFF Sbjct: 415 -DSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF 453 >2VD5-A nrPDB Length = 412 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 119/293 (40%), Gaps = 15/293 (5%) Query: 33 LDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE 92 L I + + ++ DD E + +GRGA+ V ++ +GQ+ A+K + + Sbjct: 43 LQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKR 102 Query: 93 -QKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 + + + D + + A E +++ ME + G+ IP Sbjct: 103 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGG--DLLTLLSKFGERIP 160 Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT 211 ++ IV A++ +H +L +HRD+KP N+L++ G +++ DFG L Sbjct: 161 AEMARFYLAEIVMAIDSVH-RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVR 219 Query: 212 --IDAGCKPYMAPERINP---ELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPF 264 + G Y++PE + Y + D W+LG+ E+ + P+ DS + Sbjct: 220 SLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETY 279 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP---TYPELMQHPFF 314 ++ E S L + E DF + L + R + HPFF Sbjct: 280 GKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFF 331 >4O2Z-A nrPDB Length = 377 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 74/343 (21%), Positives = 138/343 (40%), Gaps = 47/343 (13%) Query: 20 FEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM 79 + Q + P+ + ++ FEV + + LG GAYG+ +G+ + Sbjct: 15 YFQGNQELSVPKIVGDFKVYNVSGSPFEVPSK-YTLLKILGMGAYGIACSCLDGDTGEKV 73 Query: 80 AVKRIRATVNS-QEQKRLLMDLDISMRTVDCPFTVT-------FYGALFREGDVWICMEL 131 ++K+ R ++ KR+L ++D+ MR + DV++ L Sbjct: 74 SIKKCRDVFRDVEDGKRVLREIDM-MRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPL 132 Query: 132 MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG 191 MD ++ + Q + E + I++ L++LHS +V HRD+KP+N++ N Sbjct: 133 MDVDMNVVLR----SRQVLEESHMQYFVYQILRGLKYLHS-ANVAHRDLKPANLVTNISC 187 Query: 192 QVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 ++K+ DFG+S + V T + Y PE + L YS DIWS+G E+ Sbjct: 188 ELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELL---LENTNYSTAVDIWSVGCIFAEM 244 Query: 251 AILRFPYDSWGTPFQQLKQVVE----------------EPSPQLPADKFS---------- 284 + + T QL+ + + E +LP + Sbjct: 245 YNRKPVFPGRNT-MDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAG 303 Query: 285 -AEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 E +DF S+ + +RPT +++ HP+ + + Sbjct: 304 NTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTC 346 >3FXW-A nrPDB Length = 336 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 112/279 (40%), Gaps = 28/279 (10%) Query: 51 DDLEPIM-ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 DD + LG G G V + H +GQ A+K + + + ++D + Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL------YDSPKARQEVDHHWQASGG 81 Query: 110 PFTVTFYGALFREGD----VWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVK 164 P V + I ME M+ + + ++ ++G Q E +I I Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGG--ELFSRIQERGDQAFTEREAAEIMRDIGT 139 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 A++ LHS ++ HRDVKP N+L + +K+ DFG + + +T Y+A Sbjct: 140 AIQFLHSH-NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQT-PCYTPYYVA 197 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP--FQQLKQVVEEPSPQLP 279 PE + PE Y D+WSLG+ M L P+ S +K+ + P Sbjct: 198 PEVLGPE----KYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFP 253 Query: 280 ADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 ++ S + LK + ER T + M HP+ Sbjct: 254 NPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 292 >3HKO-A nrPDB Length = 345 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 74/339 (21%), Positives = 122/339 (35%), Gaps = 64/339 (18%) Query: 40 SIGNQNFEVKA-------DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT----V 88 S G +N + +G+G+YGVV + I A+K + + Sbjct: 8 SSGRENLYFQGGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQI 67 Query: 89 NSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS-----LDKFYKQV 143 N ++ +R+ ++ M+ + P Y E + + MEL L+ F Sbjct: 68 NPKDVERIKTEVR-LMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDS 126 Query: 144 IDKG--------------------------------QTIPEDILGKIAVSIVKALEHLHS 171 K E ++ I I AL +LH+ Sbjct: 127 TGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHN 186 Query: 172 KLSVIHRDVKPSNVLI--NALGQVKMCDFGISGYL-----VDSVAKTIDAGCKPYMAPER 224 + + HRD+KP N L N ++K+ DFG+S + T AG ++APE Sbjct: 187 Q-GICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEV 245 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYD---SWGTPFQQLKQVVEEPSPQLPAD 281 +N + Y K D WS G+ + L + P+ T Q L + + +P + Sbjct: 246 LNT--TNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNY--N 301 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESK 320 S D S L +N ER +QHP+ + K Sbjct: 302 VLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDK 340 >5G6V-A nrPDB Length = 324 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 118/293 (40%), Gaps = 36/293 (12%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + + +LG G Y V K + + ++A+K IR + ++ ++ + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS-LLKDLKH 59 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 VT + + E + + E +D L ++ G I + +++ L + Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC---GNIINMHNVKLFLFQLLRGLAYC 116 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMCDFGISG-YLVDSVAKTIDAGCKPYMAPERINPE 228 H + V+HRD+KP N+LIN G++K+ DFG++ + + + Y P+ + Sbjct: 117 HRQ-KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDIL--- 172 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVV--------------- 271 L YS + D+W +G E+A R P + + +++ Sbjct: 173 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 232 Query: 272 EEPSPQLP----------ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 E + P A + ++ D ++ L+ + R + + M+HPFF Sbjct: 233 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4QNY-A nrPDB Length = 354 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 80/316 (25%), Positives = 130/316 (41%), Gaps = 48/316 (15%) Query: 51 DDLEPIMELGRGAYGVVEKMRH-VPSGQIMAVKRIRATVNSQE--QKRLLMDLDISMRTV 107 D +G G+YGVV + R +++A+KR+ + + KR+L ++ + Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIK-LLAHF 78 Query: 108 DCPFTVTFYGALFREG-----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + + L E +I M++M+T L KQV+ GQ + E + Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMETDL----KQVLRSGQELTEAHIQFFIYQA 134 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC-KPYMA 221 ++AL +HS VIHRD+ P+N+L+N +K+CDFG++ D D + Y A Sbjct: 135 LRALHIIHS-AGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRA 193 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV---------- 271 PE + + K YS + D+W +G + EL P QL ++V Sbjct: 194 PELV---MEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGTPSEED 249 Query: 272 -------------EEPSPQLPADK------FSAEFVDFTSQCLKKNSKERPTYPELMQHP 312 ++ S + AD S E +D L N K R T + M+HP Sbjct: 250 INSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHP 309 Query: 313 FFTLHESKGTDVASFV 328 F D S+ Sbjct: 310 FLEQLHDDADDNLSYA 325 >6QAU-A nrPDB Length = 280 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 74/286 (25%), Positives = 124/286 (43%), Gaps = 24/286 (8%) Query: 42 GNQNFEVKAD-DLEPIMELGRGAYGVVEKMRHV-PSGQIMAVKRIRATVNSQEQKRLLMD 99 G + EV D + +G GA+ VV + RH + +A+K I S+ Q L + Sbjct: 1 GGGSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKE 60 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 159 + I ++ + V Y V++ ME + Y Q T+ ED + Sbjct: 61 IKI-LKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQ---AKGTLSEDTIRVFL 116 Query: 160 VSIVKALEHLHSKLSVIHRDVKPSNVLIN---------ALGQVKMCDFGISGYLVDSVAK 210 I A+ LHSK +IHRD+KP N+L++ + ++K+ DFG + YL ++ Sbjct: 117 HQIAAAMRILHSK-GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMA 175 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 G YMAPE I + Y K+D+WS+G + + + + P+ Q L+ Sbjct: 176 ADLCGSPMYMAPEVI----MSQHYDAKADLWSIGTVIYQCLVGKPPFQ--ANSPQDLRMF 229 Query: 271 VEEPSPQLP--ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 E+ +P + S + L++N K+R + HPF Sbjct: 230 YEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL 275 >3AOX-A nrPDB Length = 344 Score = 213 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 112/281 (39%), Gaps = 26/281 (9%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 EV ++ I LG GA+G V + + + PS +AVK + + Q++ LM+ Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEAL 102 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDI----LGK 157 I + + V G + +I +ELM K + + + P + L Sbjct: 103 IISK-FNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLH 161 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG---QVKMCDFGISGYLVDSVAKTIDA 214 +A I ++L IHRD+ N L+ G K+ DFG++ + + Sbjct: 162 VARDIACGCQYLEEN-HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYR-KG 219 Query: 215 GCK----PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQ 269 GC +M PE + ++ K+D WS G+ + E+ PY S Q++ + Sbjct: 220 GCAMLPVKWMPPEAFMEGI----FTSKTDTWSFGVLLWEIFSLGYMPYPSKSN--QEVLE 273 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 V P +QC + ++RP + +++ Sbjct: 274 FVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >6BDL-A nrPDB Length = 347 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 65/275 (23%), Positives = 119/275 (43%), Gaps = 18/275 (6%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHV-PSGQIMAVKRIRA--TVNSQEQKRLLMDLDISM 104 +K D I LG G +G VE ++ + A+K ++ V++++Q+ + + I M Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI-M 89 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + F V Y +++ ME + + + D+G + + +V+ Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGG--ELWTILRDRG-SFEDSTTRFYTACVVE 146 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 A +LHSK +I+RD+KP N++++ G K+ DFG + + G Y+APE Sbjct: 147 AFAYLHSK-GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEI 205 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 I KG+ + +D WSLGI M EL P+ S P + ++ K + Sbjct: 206 I----LNKGHDISADYWSLGILMYELLTGSPPF-SGPDPMKTYNIILRGIDMIEFPKKIA 260 Query: 285 AEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 + + + N ER ++ +H +F Sbjct: 261 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF 295 >5U6B-A nrPDB Length = 307 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 115/281 (40%), Gaps = 18/281 (6%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSG--QIMAVKRIRATVNSQEQKRLLMDLD 101 ++ V + LG G +G V + + +AVK ++ + ++ + + Sbjct: 16 RDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 75 Query: 102 ISMRTVDCPFTVTFYGALFREGDV------WICMELMDTSLD---KFYKQVIDKGQTIPE 152 + M+ D P + G F+ + + + M Y ++ D+ +P Sbjct: 76 VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT 135 Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212 +L K I +E+L S IHRD+ N ++N V + DFG+S + + Sbjct: 136 QMLVKFMADIASGMEYL-STKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY-- 192 Query: 213 DAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQV 270 G M + I E L + Y+ KSD+WS G+TM E+A + PY G ++ Sbjct: 193 RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYP--GVENSEIYDY 250 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + + + S+C + N ++RP++ EL + Sbjct: 251 LRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 291 >1U59-A nrPDB Length = 287 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 119/266 (44%), Gaps = 19/266 (7%) Query: 48 VKADDLEPIM-ELGRGAYGVVEKMRHVPSGQI--MAVKRIRATVNSQEQKRLLMDLDISM 104 +K D+L ELG G +G V + + + +A+K ++ + + ++ + I M Sbjct: 6 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-M 64 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 +D P+ V G E + + ME+ +K ++ K + IP + ++ + Sbjct: 65 HQLDNPYIVRLIGVCQAEA-LMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELLHQVSM 121 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKP---YM 220 +++L K + +HRD+ NVL+ K+ DFG+S L D T + K + Sbjct: 122 GMKYLEEK-NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 APE I N + +S +SD+WS G+TM E L+ + PY P ++ +E+ Sbjct: 181 APECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMEC 234 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTY 305 + E S C ++RP + Sbjct: 235 PPECPPELYALMSDCWIYKWEDRPDF 260 >4LRM-A nrPDB Length = 334 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 116/272 (42%), Gaps = 22/272 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIM----AVKRIRATVNSQEQKRLLMDLDIS 103 +K + + I LG GA+G V K +P G+ + A+K +R + + K +L + + Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV- 74 Query: 104 MRTVDCP---FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 M +VD P G V + +LM V + I L V Sbjct: 75 MASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGC--LLDYVREHKDNIGSQYLLNWCV 131 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK--- 217 I K + +L + ++HRD+ NVL+ VK+ DFG++ L + G K Sbjct: 132 QIAKGMNYLEDR-RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPI 190 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSP 276 +MA E I + Y+ +SD+WS G+T+ EL PYD G P ++ ++E+ Sbjct: 191 KWMALESI----LHRIYTHQSDVWSYGVTVWELMTFGSKPYD--GIPASEISSILEKGER 244 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + +C ++ RP + EL Sbjct: 245 LPQPPICTIDVYMIMVKCWMIDADSRPKFREL 276 >3OMV-A nrPDB Length = 307 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 120/270 (44%), Gaps = 14/270 (5%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 +E++A ++ +G G++G V K + +AVK ++ + EQ + + +R Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + F G + ++ I + + S YK + + L IA + Sbjct: 88 KTRHVNILLFMG-YMTKDNLAIVTQWCEGS--SLYKHLHVQETKFQMFQLIDIARQTAQG 144 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG---YLVDSVAKTIDAGCKPYMAP 222 +++LH+K ++IHRD+K +N+ ++ VK+ DFG++ S G +MAP Sbjct: 145 MDYLHAK-NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAP 203 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP-SPQLPA- 280 E I + + +S +SD++S GI + EL PY Q + V SP L Sbjct: 204 EVIRMQ-DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKL 262 Query: 281 -DKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + C+KK +ERP +P+++ Sbjct: 263 YKNCPKAMKRLVADCVKKVKEERPLFPQIL 292 >4E7W-A nrPDB Length = 394 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 124/296 (41%), Gaps = 44/296 (14%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 +G G++GVV + + V S + +A+K++ + +L I MR V P Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN-----RELQI-MRIVKHPNV 94 Query: 113 VTFYGALFREGD------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V + GD + + +E + ++ + + QT+P ++ ++++L Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 167 EHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 ++HS + + HRD+KP N+L++ G +K+ DFG + L+ + Y APE I Sbjct: 155 AYIHS-IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELI 213 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVV------------ 271 Y+ DIWS G M EL + P +S ++ +V+ Sbjct: 214 ---FGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMN 270 Query: 272 ----EEPSPQLPADKFS--------AEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 E PQ+ FS + +D S+ L+ R T E + HPFF Sbjct: 271 PNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFD 326 >5KMM-A nrPDB Length = 329 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 111/283 (39%), Gaps = 30/283 (10%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVP-----SGQIMAVKRIRATVNSQEQKRLLMDLD 101 +K D+ ELG GA+G V ++AVK ++ + ++ + + Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAE 89 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYK------QVIDKGQ-----T 149 + + V F+G + + E M L++F + +++ G+ Sbjct: 90 -LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP 148 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 + L +A + + +L + L +HRD+ N L+ VK+ DFG+S + + Sbjct: 149 LGLGQLLAVASQVAAGMVYL-AGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 210 KTIDAGC---KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQ 265 + +M PE I + ++ +SD+WS G+ + E+ + P+ + Sbjct: 208 YRVGGRTMLPIRWMPPESI----LYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN-TE 262 Query: 266 QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + + + P E C ++ ++R + ++ Sbjct: 263 AIDCITQGRELERPR-ACPPEVYAIMRGCWQREPQQRHSIKDV 304 >5AIR-A nrPDB Length = 430 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 121/296 (40%), Gaps = 43/296 (14%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 +G G++GVV + + SG+++A+K++ + +L I MR +D Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-----RELQI-MRKLDHCNI 119 Query: 113 VTFYGALFREGD------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V + G+ + + ++ + ++ + + QT+P + + ++L Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQV-KMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 ++HS + HRD+KP N+L++ V K+CDFG + LV + Y APE I Sbjct: 180 AYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELI 238 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGTPFQQLKQVVEEPS-------- 275 Y+ D+WS G + EL + + P DS ++ +V+ P+ Sbjct: 239 ---FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 276 --------PQLPADKF--------SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 PQ+ A + E + S+ L+ R T E H FF Sbjct: 296 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFD 351 >4E20-A nrPDB Length = 290 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 118/286 (41%), Gaps = 35/286 (12%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPS----GQIMAVKRIRATVNSQEQKRLLMDLDIS 103 L+ I +LG G +G V + P+ G+++AVK ++ Q + +++I Sbjct: 5 FHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEI- 63 Query: 104 MRTVDCPFTVTFYGALFREGD--VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAV 160 +RT+ V + G +G+ V + ME + SL + + + L A Sbjct: 64 LRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPR-----HCVGLAQLLLFAQ 118 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA--GCKP 218 I + + +LH++ IHR + NVL++ VK+ DFG++ + + G P Sbjct: 119 QICEGMAYLHAQ-HYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 177 Query: 219 --YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLK-------- 268 + APE L + + SD+WS G+T+ EL S T F +L Sbjct: 178 VFWYAPEC----LKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMT 233 Query: 269 -----QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 +++E D+ E C + + RPT+ L+ Sbjct: 234 VLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLV 279 >5HI2-A nrPDB Length = 283 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 120/274 (43%), Gaps = 19/274 (6%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 + ++E+ + +G G++G V K + +AVK + Q+ + ++ + Sbjct: 12 SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----TPQQLQAFKNEVGV 64 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 +R + F G + + I + + S Y + L IA Sbjct: 65 -LRKTRHVNILLFMG-YSTKPQLAIVTQWCEGS--SLYHHLHASETKFEMKKLIDIARQT 120 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG---YLVDSVAKTIDAGCKPY 219 + +++LH+K S+IHRD+K +N+ ++ VK+ DFG++ S +G + Sbjct: 121 ARGMDYLHAK-SIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILW 179 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP-SPQL 278 MAPE I + + YS +SD+++ GI + EL + PY + Q ++ V SP L Sbjct: 180 MAPEVIRMQ-DSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDL 238 Query: 279 P--ADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 ++CLKK ERP++P ++ Sbjct: 239 SKVRSNCPKRMKRLMAECLKKKRDERPSFPRILA 272 >2W96-B nrPDB Length = 306 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 113/301 (37%), Gaps = 39/301 (12%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ-KRLLMDLDISMRT--V 107 EP+ E+G GAYG V K R SG +A+K +R + + ++ + R Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 108 DCPFTVTFYGALFREG-----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + P V V + E +D L + + G +P + + + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG--LPAETIKDLMRQF 121 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 ++ L+ LH+ ++HRD+KP N+L+ + G VK+ DFG++ +A Y AP Sbjct: 122 LRGLDFLHANC-IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAP 180 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ--QLKQVVEEPS----- 275 E L Q Y+ D+WS+G E+ + + Q ++ ++ P Sbjct: 181 EV----LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 236 Query: 276 --PQLPADKFSA---------------EFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 LP F + L N +R + +QH + E Sbjct: 237 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 296 Query: 319 S 319 Sbjct: 297 G 297 >5O0Y-A nrPDB Length = 579 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 115/285 (40%), Gaps = 26/285 (9%) Query: 64 YGVVEKMRHVPSGQIMAVKR------IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 + V K + + +AVK R K + I + +D P V Y Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRI-HKELDHPRIVKLYD 355 Query: 118 ALFREGD-VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS-KLSV 175 + D +E + + FY + + + + E I + IV AL++L+ K + Sbjct: 356 YFSLDTDSFCTVLEYCEGNDLDFY---LKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI 412 Query: 176 IHRDVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTID--------AGCKPYMAPER 224 IH D+KP N+L+ A G++K+ DFG+S + D ++D AG Y+ PE Sbjct: 413 IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPEC 472 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ--VVEEPSPQLPADK 282 S K D+WS+G+ + R P+ + L++ +++ Q P Sbjct: 473 FVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKP 532 Query: 283 -FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 + E F +CL ++R +L P+ H K +S Sbjct: 533 VVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSS 577 >4NEU-A nrPDB Length = 333 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 126/304 (41%), Gaps = 27/304 (8%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 ++K+ D EL G +G V H G ++ +K + N E L++ M Sbjct: 19 IKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMN 77 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + V G + EG + ME M+ V+ + P + G+I + I++ Sbjct: 78 RLRHSRVVKLLGVIIEEGKYSLVMEYMEKG---NLMHVLKAEMSTPLSVKGRIILEIIEG 134 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY--------------LVDSVAKT 211 + +LH K VIH+D+KP N+L++ +K+ D G++ + Sbjct: 135 MCYLHGK-GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK 193 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 + G YMAPE +N + KSD++S + + + + PY++ Q + + Sbjct: 194 KNGGTLYYMAPEHLNDV--NAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIK 251 Query: 272 EEPSPQLPA--DKFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFF--TLHESKGTDVA 325 P + + E + C + N + RPT+P + + PF+ L ES DV Sbjct: 252 SGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVK 311 Query: 326 SFVK 329 S K Sbjct: 312 SLKK 315 >3ZBF-A nrPDB Length = 322 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 110/280 (39%), Gaps = 27/280 (9%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVP-----SGQI-MAVKRIRATVNSQEQKRLLMDLD 101 + L + LG GA+G V + V SG+I +AVK ++ QE+ L + Sbjct: 30 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 89 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK----GQTIPEDILGK 157 M + P + G +I +ELM+ Y + G + L Sbjct: 90 -LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 148 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDSVAKTI 212 + V I K +L ++ IHRD+ N L+ + VK+ DFG++ + + Sbjct: 149 LCVDISKGCVYL-ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 207 Query: 213 DAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLK 268 +MAPE + + ++ +SD+WS GI + E+ PY + + Sbjct: 208 RGEGLLPVRWMAPESLMDGI----FTTQSDVWSFGILIWEILTLGHQPYPAHSN--LDVL 261 Query: 269 QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 V+ P + + +QC + +RPT+ + Sbjct: 262 NYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 301 >5HIE-A nrPDB Length = 302 Score = 210 bits (534), Expect = 9e-55, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 122/287 (42%), Gaps = 19/287 (6%) Query: 30 PRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN 89 R+ + ++E+ + +G G++G V K + +AVK + Sbjct: 15 DRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML----T 67 Query: 90 SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 Q+ + ++ + +R + F G + + I + + S Y + Sbjct: 68 PQQLQAFKNEVGV-LRKTRHVNILLFMG-YSTKPQLAIVTQWCEGS--SLYHHLHIIETK 123 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG---YLVD 206 L IA + +++LH+K S+IHRD+K +N+ ++ VK+ DFG++ Sbjct: 124 FEMIKLIDIARQTAQGMDYLHAK-SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSG 182 Query: 207 SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQ 266 S +G +MAPE I + ++ YS +SD+++ GI + EL + PY + Q Sbjct: 183 SHQFEQLSGSILWMAPEVIRMQ-DKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 241 Query: 267 LKQVVEEP-SPQLP--ADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + V SP L ++CLKK ERP +P+++ Sbjct: 242 IFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA 288 >5AP3-A nrPDB Length = 313 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 118/300 (39%), Gaps = 24/300 (8%) Query: 36 KACISIGNQNFEVKA-----DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS 90 + + +G +N ++ + ++G G V ++ + QI A+K + Sbjct: 8 SSGVDLGTENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEAD 66 Query: 91 QEQKRLLM-DLDISMRTVDC-PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQ 148 + ++ + + Y + +++ ME + L+ + K K + Sbjct: 67 NQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNGWLK----KKK 122 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 +I ++++A+ +H ++H D+KP+N LI G +K+ DFGI+ + Sbjct: 123 SIDPWERKSYWKNMLEAVHTIHQH-GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDT 180 Query: 209 A---KTIDAGCKPYMAPERINPELNQKGYSVKS-------DIWSLGITMIELAILRFPYD 258 K G YM PE I + + D+WSLG + + + P+ Sbjct: 181 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 240 Query: 259 SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 +L +++ D + D CLK++ K+R + PEL+ HP+ + Sbjct: 241 QIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 300 >2W1I-A nrPDB Length = 326 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 133/304 (43%), Gaps = 36/304 (11%) Query: 32 DLDSKACISIGNQN---FEVKADDLEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRI 84 +L + + ++ + + L+ + +LG+G +G VE R+ P +G+++AVK++ Sbjct: 19 NLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL 78 Query: 85 RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG--DVWICMELMDTSLDKFYKQ 142 + + + + +++I ++++ V + G + G ++ + ME + Sbjct: 79 QHS-TEEHLRDFEREIEI-LKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYG--SLRDY 134 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 + + I L + I K +E+L +K IHRD+ N+L+ +VK+ DFG++ Sbjct: 135 LQKHKERIDHIKLLQYTSQICKGMEYLGTK-RYIHRDLATRNILVENENRVKIGDFGLTK 193 Query: 203 YLVDS--VAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL----- 253 L K + G P + APE L + +SV SD+WS G+ + EL Sbjct: 194 VLPQDKEYYKVKEPGESPIFWYAPE----SLTESKFSVASDVWSFGVVLYELFTYIEKSK 249 Query: 254 RFP--YDSWGTPFQQ-------LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 P + +Q L ++++ D E ++C N +RP+ Sbjct: 250 SPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPS 309 Query: 305 YPEL 308 + +L Sbjct: 310 FRDL 313 >3IO7-A nrPDB Length = 313 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 131/297 (44%), Gaps = 34/297 (11%) Query: 37 ACISIGNQNF-EVKADDLEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRIRATVNSQ 91 + G+ N + + L+ + +LG+G +G VE R+ P +G+++AVK+++ + + Sbjct: 13 GLVPRGSHNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHS-TEE 71 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREG--DVWICMELMDTSLDKFYKQVIDKGQT 149 + +++I ++++ V + G + G ++ + ME + + + Sbjct: 72 HLRDFEREIEI-LKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYG--SLRDYLQKHKER 128 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-- 207 I L + I K +E+L +K IHRD+ N+L+ +VK+ DFG++ L Sbjct: 129 IDHIKLLQYTSQICKGMEYLGTK-RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE 187 Query: 208 VAKTIDAGCKP--YMAPERINPELNQKGYSVKSDIWSLGITMIELAIL-----RFP--YD 258 K + G P + APE L + +SV SD+WS G+ + EL P + Sbjct: 188 YYKVKEPGESPIFWYAPE----SLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 243 Query: 259 SWGTPFQQ-------LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +Q L ++++ D E ++C N +RP++ +L Sbjct: 244 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >6FER-A nrPDB Length = 309 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 43/297 (14%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMR--------------HVPSGQ--IMAVKRIRATVNS 90 E L +LG G +G V V + Q ++AVK +RA N Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 91 QEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKG-- 147 + L ++ I R D P + + + + E M+ L++F + Sbjct: 65 NARNDFLKEIKIMSRLKD-PNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSS 123 Query: 148 ----QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY 203 +T+ L +A I +++L S L+ +HRD+ N L+ +K+ DFG+S Sbjct: 124 SSDVRTVSYTNLKFMATQIASGMKYL-SSLNFVHRDLATRNCLVGKNYTIKIADFGMSRN 182 Query: 204 LVDSVAKTIDAGC---KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL--RFPYD 258 L I +M+ E I ++ SD+W+ G+T+ E PY Sbjct: 183 LYSGDYYRIQGRAVLPIRWMSWESILL----GKFTTASDVWAFGVTLWETFTFCQEQPYS 238 Query: 259 SWGTPFQQLKQVVEE-------PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +Q+ + E + C ++++K RP++ E+ Sbjct: 239 QLSD--EQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >4HZS-A nrPDB Length = 341 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 115/269 (42%), Gaps = 20/269 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHV-PSGQIM--AVKRIRATVNSQEQK--RLLMDLDISMR 105 DL + +LG G++GVV + PSG+ + AVK ++ V SQ + + +++ +M Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN-AMH 70 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 ++D + YG + + + EL L ++ L + AV + + Sbjct: 71 SLDHRNLIRLYGVVLTP-PMKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 127 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL----VDSVAKTIDAGCKPYMA 221 + +L SK IHRD+ N+L+ VK+ DFG+ L V + + A Sbjct: 128 MGYLESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 PE + + +S SD W G+T+ E+ + P+ Q L ++ +E Sbjct: 187 PESLKT----RTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRP 241 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + + QC ++RPT+ L Sbjct: 242 EDCPQDIYNVMVQCWAHKPEDRPTFVALR 270 >4YHJ-A nrPDB Length = 584 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 65/325 (20%), Positives = 131/325 (40%), Gaps = 24/325 (7%) Query: 7 KKRNPGLKIPKEAFEQPQ--TSSTPPRDLDSKACISIGNQNFE------VKADDLEPIME 58 K+ NP K +E P + + S Q ++ V + Sbjct: 134 KEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQ-WKWLERQPVTKNTFRHYRV 192 Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL-MDLDISMRTVDCPFTVTFYG 117 LG+G +G V + +G++ A K+++ + + + ++ + V F V+ Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 A + + + + +M+ KF+ + E A + LE L + +++ Sbjct: 253 AYETKDALCLVLTIMNGGDLKFHIYNL-GNPGFDEQRAVFYAAELCCGLEDL-QRERIVY 310 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVK 237 RD+KP N+L++ G +++ D G++ + + G YMAPE +N E Y+ Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNE----KYTFS 366 Query: 238 SDIWSLGITMIELAILRFPYDSWGT--PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 D W LG + E+ P+ + ++++ Q ++ + + ++KFS + L Sbjct: 367 PDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEY-SEKFSEDAKSICRMLL 425 Query: 296 KKNSKERP-----TYPELMQHPFFT 315 KN +R + QHP F Sbjct: 426 TKNPSKRLGCRGEGAAGVKQHPVFK 450 >3MIA-A nrPDB Length = 351 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 56/308 (18%), Positives = 110/308 (35%), Gaps = 51/308 (16%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE-QKRLLMDLDISMRTVDC 109 E + ++G+G +G V K RH +GQ +A+K++ + L ++ I ++ + Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI-LQLLKH 75 Query: 110 PFTVTFYGALFR--------EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 V +G +++ + + L V+ K + ++ Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQM 132 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-----VDSVAKTIDAGC 216 ++ L ++H ++HRD+K +NVLI G +K+ DFG++ T Sbjct: 133 LLNGLYYIHRN-KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 Query: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ----------- 265 Y PE + L ++ Y D+W G M E+ Q Sbjct: 192 LWYRPPELL---LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 Query: 266 -----------QLKQVVE-------EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPE 307 +L + +E + +L A +D + L + +R + Sbjct: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 Query: 308 LMQHPFFT 315 + H FF Sbjct: 309 ALNHDFFW 316 >3GC0-A nrPDB Length = 329 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 110/301 (36%), Gaps = 41/301 (13%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D I +LG G YG V K + + +A+KRIR + + ++ + Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHR 93 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 + + + + E + L K+ +DK + ++ ++ + H Sbjct: 94 NIIELKSVIHHNHRLHLIFEYAENDLKKY----MDKNPDVSMRVIKSFLYQLINGVNFCH 149 Query: 171 SKLSVIHRDVKPSNVLIN-----ALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPER 224 S+ +HRD+KP N+L++ +K+ DFG++ + T + Y PE Sbjct: 150 SR-RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEI 208 Query: 225 INPELNQKGYSVKSDIWSLGITMIELA--ILRFPYDSWGTPFQQLKQVVEEPS------- 275 + L + YS DIWS+ E+ FP DS ++ +V+ P Sbjct: 209 L---LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGV 265 Query: 276 ------PQLPADKFSAEFVDFT------------SQCLKKNSKERPTYPELMQHPFFTLH 317 Q + L+ + +R + ++HP+F+ + Sbjct: 266 TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHN 325 Query: 318 E 318 + Sbjct: 326 D 326 >6DBN-A nrPDB Length = 316 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 121/314 (38%), Gaps = 31/314 (9%) Query: 20 FEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVP----S 75 D+ S+ + + L+ I +LG G +G VE R+ P + Sbjct: 4 MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT 63 Query: 76 GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD--VWICMELMD 133 G+ +AVK ++ L +++I +R + V + G +G + + ME + Sbjct: 64 GEQVAVKSLKPESGGNHIADLKKEIEI-LRNLYHENIVKYKGICTEDGGNGIKLIMEFLP 122 Query: 134 TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQV 193 + K + + I K AV I K +++L S+ +HRD+ NVL+ + QV Sbjct: 123 SGSLK--EYLPKNKNKINLKQQLKYAVQICKGMDYLGSR-QYVHRDLAARNVLVESEHQV 179 Query: 194 KMCDFGISGYLVDSVAKTIDAGCKP----YMAPERINPELNQKGYSVKSDIWSLGITMIE 249 K+ DFG++ + + + APE L Q + + SD+WS G+T+ E Sbjct: 180 KIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC----LMQSKFYIASDVWSFGVTLHE 235 Query: 250 LAIL----RFP---YDSWGTPFQ------QLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296 L P + P +L ++E E +C + Sbjct: 236 LLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWE 295 Query: 297 KNSKERPTYPELMQ 310 R ++ L++ Sbjct: 296 FQPSNRTSFQNLIE 309 >3E3P-A nrPDB Length = 360 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 64/313 (20%), Positives = 125/313 (39%), Gaps = 46/313 (14%) Query: 42 GNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR-IRATVNSQEQKRLLMDL 100 ++ + D + G+G +G V+ + +G +A+K+ I+ + +++ DL Sbjct: 14 ADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDL 73 Query: 101 DISMRTVDCPFTVTFYGALFREGD-------VWICMELMDTSLDKFYKQVIDKGQTIPED 153 + + P V + G+ + + ME + +L + + + P Sbjct: 74 AV----LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPI 129 Query: 154 ILGKIAVSIVKALEHLH-SKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKT 211 ++ +++++ LH ++V HRD+KP NVL+N G +K+CDFG + L S Sbjct: 130 LIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNV 189 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQ 269 + Y APE I + Y+ DIWS+G E+ + + D+ ++ + Sbjct: 190 AYICSRYYRAPELI---FGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVR 246 Query: 270 VVEEPSPQLPADKFSA---------------------------EFVDFTSQCLKKNSKER 302 V+ PS ++ + E D S L+ +ER Sbjct: 247 VLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEER 306 Query: 303 PTYPELMQHPFFT 315 E + HP+F Sbjct: 307 MKPYEALCHPYFD 319 >3QUP-A nrPDB Length = 323 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 113/305 (37%), Gaps = 33/305 (10%) Query: 33 LDSKACISIGNQNFE---VKADDLEPIMELGRGAYGVVEKMRHVPSG---QIMAVKRIRA 86 LDS + E + LG+G +G V + + +AVK ++A Sbjct: 2 LDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKA 61 Query: 87 TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR---EGDV---WICMELMDTSLDKFY 140 + + + M+ D P G R +G + + + M + Sbjct: 62 DIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAF 121 Query: 141 ---KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCD 197 ++ + +P L + V I +E+L S + IHRD+ N ++ V + D Sbjct: 122 LLASRIGENPFNLPLQTLVRFMVDIACGMEYL-SSRNFIHRDLAARNCMLAEDMTVCVAD 180 Query: 198 FGISGYLVDSVAKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-L 253 FG+S + K ++A E + L Y+V SD+W+ G+TM E+ Sbjct: 181 FGLSRKIYSGDYYRQGCASKLPVKWLALESLADNL----YTVHSDVWAFGVTMWEIMTRG 236 Query: 254 RFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY-------P 306 + PY G ++ + + + E D QC + K+RP++ Sbjct: 237 QTPYA--GIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELE 294 Query: 307 ELMQH 311 ++ H Sbjct: 295 NILGH 299 >6CCF-A nrPDB Length = 290 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 127/298 (42%), Gaps = 40/298 (13%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE--------------- 92 ++ + + E+G+GAYGVV + + A+K + ++ Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 93 ----------QKRLLMDLDISMRTVDCPFTVTFYGALFR--EGDVWICMELMDTSLDKFY 140 +R+ ++ I ++ +D V L E ++++ +L+ Sbjct: 62 QGGPAKQLLPLERVYQEIAI-LKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVM 118 Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI 200 + DK E+ ++ LE+LH + ++HRD+KPSN+L+ G VK+ DFG+ Sbjct: 119 EVPCDK--PFSEEQARLYLRDVILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGV 175 Query: 201 SGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSVKS-DIWSLGITMIELAILRFPYD 258 S + + AG +MAPE I+ + +S K+ D+W+ G+T+ + P+ Sbjct: 176 SNQFEGNDAQLSSTAGTPAFMAPEAISDS--GQSFSGKALDVWATGVTLYCFVYGKCPF- 232 Query: 259 SWGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 L + ++ P + + S E D + L KN + R P++ HP+ T Sbjct: 233 -IDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVT 289 >1U54-B nrPDB Length = 291 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 115/269 (42%), Gaps = 20/269 (7%) Query: 51 DDLEPIMELGRGAYGVVEKMRHV-PSGQIM--AVKRIRATVNSQEQK--RLLMDLDISMR 105 DL + +LG G++GVV + PSG+ + AVK ++ V SQ + + +++ +M Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN-AMH 76 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 ++D + YG + + + EL L ++ L + AV + + Sbjct: 77 SLDHRNLIRLYGVVLTP-PMKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 133 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL----VDSVAKTIDAGCKPYMA 221 + +L SK IHRD+ N+L+ VK+ DFG+ L V + + A Sbjct: 134 MGYLESK-RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 PE + + +S SD W G+T+ E+ + P+ Q L ++ +E Sbjct: 193 PESLKT----RTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRP 247 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + + QC ++RPT+ L Sbjct: 248 EDCPQDIYNVMVQCWAHKPEDRPTFVALR 276 >5VD3-A nrPDB Length = 311 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 130/307 (42%), Gaps = 17/307 (5%) Query: 9 RNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFE-VKADDLEPIMELGRGAYGVV 67 L QP+ S ++ E + + LG G+YG V Sbjct: 14 GTENLYFQSMHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEV 73 Query: 68 EKMRHVPSGQIMAVKR-IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVW 126 K+R G++ AVKR + +++ R L ++ + P V A G ++ Sbjct: 74 FKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILY 133 Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + EL SL + + G ++PE + + AL HLHS+ ++H DVKP+N+ Sbjct: 134 LQTELCGPSLQQHCEAW---GASLPEAQVWGYLRDTLLALAHLHSQ-GLVHLDVKPANIF 189 Query: 187 INALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGIT 246 + G+ K+ DFG+ L + A + G YMAPE + Y +D++SLG+T Sbjct: 190 LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS-----YGTAADVFSLGLT 244 Query: 247 MIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 ++E+A + P G +QQL+Q P S+E L+ + K R T Sbjct: 245 ILEVACNMELP--HGGEGWQQLRQGYLPPEFTA---GLSSELRSVLVMMLEPDPKLRATA 299 Query: 306 PELMQHP 312 L+ P Sbjct: 300 EALLALP 306 >6CKI-A nrPDB Length = 316 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 120/303 (39%), Gaps = 35/303 (11%) Query: 43 NQNFEVKADD-LEPIM-ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 +F + +D + LG GA+ V+ ++ + Q AVK I + R+ ++ Sbjct: 3 TDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI-RSRVFREV 61 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 ++ + + E ++ E M I K + E + Sbjct: 62 EMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGG---SILSHIHKRRHFNELEASVVVQ 118 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQV---KMCDFGISGYL--------VDSVA 209 + AL+ LH+K + HRD+KP N+L QV K+CDFG+ + + + Sbjct: 119 DVASALDFLHNK-GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPE 177 Query: 210 KTIDAGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFPY----------- 257 G YMAPE + + Y + D+WSLG+ + L P+ Sbjct: 178 LLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWD 237 Query: 258 DSWGTPFQQ--LKQVVEEPSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHP 312 P Q L + ++E + P + S D S+ L +++K+R + +++QHP Sbjct: 238 RGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 297 Query: 313 FFT 315 + Sbjct: 298 WVQ 300 >4F0G-A nrPDB Length = 287 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 121/273 (44%), Gaps = 22/273 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK------RLLMDLDISM 104 +++E ++G+G +G+V K R V ++A+K + + E + ++ I M Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFI-M 77 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 ++ P V YG + + ME + Y +++DK I + ++ + I Sbjct: 78 SNLNHPNIVKLYGLMHNPPR--MVMEFVPCG--DLYHRLLDKAHPIKWSVKLRLMLDIAL 133 Query: 165 ALEHLH-SKLSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVDSVAKTIDAGCKP 218 +E++ ++HRD++ N+ + +L + K+ DFG+S V SV + G Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSV--SGLLGNFQ 191 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG-TPFQQLKQVVEEPSPQ 277 +MAPE I E ++ Y+ K+D +S + + + P+D + + + + EE Sbjct: 192 WMAPETIGAE--EESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRP 249 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + + C + K+RP + +++ Sbjct: 250 TIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >5HLW-A nrPDB Length = 299 Score = 203 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 54/259 (20%), Positives = 108/259 (41%), Gaps = 12/259 (4%) Query: 57 MELGRGAYGVVEKMRHVP-SGQIM--AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 +GRG +G V + G+ + AVK + + E + L + I M+ P + Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTE-GIIMKDFSHPNVL 84 Query: 114 TFYGALFR-EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 + G R EG + + M + + + T+ L + + K +++L SK Sbjct: 85 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVK--DLIGFGLQVAKGMKYLASK 142 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE-LNQ 231 +HRD+ N +++ VK+ DFG++ + D ++ + + + E L Sbjct: 143 -KFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQT 201 Query: 232 KGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + ++ KSD+WS G+ + EL PY T + + + L + + Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNT--FDITVYLLQGRRLLQPEYCPDPLYEV 259 Query: 291 TSQCLKKNSKERPTYPELM 309 +C ++ RP++ EL+ Sbjct: 260 MLKCWHPKAEMRPSFSELV 278 >4CRS-A nrPDB Length = 341 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 117/287 (40%), Gaps = 22/287 (7%) Query: 40 SIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA--TVNSQEQKRLL 97 S+ Q F+ D L RG +G V + + ++ A+K ++ V E L+ Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 98 MDLDI--SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 + I ++ +V PF V + + V ME + E Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT----DVFSEPRA 116 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDA 214 A +V L++LH +++RD+K N+L++ G VK+ DFG+ + + Sbjct: 117 VFYAACVVLGLQYLHEH-KIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFC 175 Query: 215 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP 274 G ++APE L + Y+ D W LG+ + E+ + P+ G +++ + Sbjct: 176 GTPEFLAPEV----LTETSYTRAVDWWGLGVLIYEMLVGESPFP--GDDEEEVFDSIVND 229 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFFTL 316 + P S E + + L++N + R ++ +HPFF L Sbjct: 230 EVRYPR-FLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRL 275 >4OTD-A nrPDB Length = 341 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 113/277 (40%), Gaps = 22/277 (7%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA--TVNSQEQKRLLMDLDISMR 105 + +D + + LGRG +G V PSG++ A+K ++ V E + L+ + I Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 68 Query: 106 --TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + PF V +G V ME + E + +V Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH----SDVFSEPRAIFYSACVV 124 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY-LVDSVAKTIDAGCKPYMAP 222 L+ LH +++RD+K N+L++ G VK+ DFG+ + + G ++AP Sbjct: 125 LGLQFLHEH-KIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAP 183 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E L Y+ D W LG+ + E+ + P+ G +++ + + P Sbjct: 184 EV----LTDTSYTRAVDWWGLGVLLYEMLVGESPFP--GDDEEEVFDSIVNDEVRYPR-F 236 Query: 283 FSAEFVDFTSQCLKKNSKERP-----TYPELMQHPFF 314 SAE + + L++N + R ++ + PFF Sbjct: 237 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFF 273 >5U6C-A nrPDB Length = 315 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 109/293 (37%), Gaps = 20/293 (6%) Query: 32 DLDSKACISIGN--QNFEVKADDLEPIMELGRGAYGVVEKMRHVP---SGQIMAVKRIRA 86 +L + + N ++ + + L LG G +G V + + +AVK ++ Sbjct: 15 NLYFQGSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKL 74 Query: 87 TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG-----DVWICMELMDTSLD---K 138 +SQ + + M+ P + G + + M Sbjct: 75 DNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYL 134 Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 Y ++ + IP L K V I +E+L S + +HRD+ N ++ V + DF Sbjct: 135 LYSRLETGPKHIPLQTLLKFMVDIALGMEYL-SNRNFLHRDLAARNCMLRDDMTVCVADF 193 Query: 199 GISGYLVDSVAKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAI-LRFP 256 G+S + G M + I E L + Y+ KSD+W+ G+TM E+A P Sbjct: 194 GLSKKIYSGDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTP 251 Query: 257 YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 Y G ++ + + E + C + + +RPT+ L Sbjct: 252 YP--GVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLR 302 >3PLS-A nrPDB Length = 298 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 54/283 (19%), Positives = 110/283 (38%), Gaps = 22/283 (7%) Query: 57 MELGRGAYGVVEKMRHVPSGQ---IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 +G+G +GVV ++ Q A+K + Q+ + L + + MR ++ P + Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLRE-GLLMRGLNHPNVL 85 Query: 114 TFYGALFREGDV-WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 G + + + + M + + + T+ L + + + +E+L + Sbjct: 86 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVK--DLISFGLQVARGMEYLAEQ 143 Query: 173 LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE-LNQ 231 +HRD+ N +++ VK+ DFG++ ++D ++ + + E L Sbjct: 144 -KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQT 202 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 ++ KSD+WS G+ + EL P PF L + + + Sbjct: 203 YRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFD-LTHFLAQGRRLPQPEYCPDSLYQVM 261 Query: 292 SQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 QC + + RPT+ L+ +V V +LGD Sbjct: 262 QQCWEADPAVRPTFRVLV------------GEVEQIVSALLGD 292 >3RP9-A nrPDB Length = 458 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 74/405 (18%), Positives = 150/405 (37%), Gaps = 103/405 (25%) Query: 4 SKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGA 63 + ++ N G + +Q A + + ++++ D E +G G+ Sbjct: 7 AAAQQHNSGTQHTVSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIP-DRYEIRHLIGTGS 65 Query: 64 YGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA---- 118 YG V + +++A+K+I R + + KR+L ++ I R ++ V Sbjct: 66 YGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNR-LNHDHVVKVLDIVIPK 124 Query: 119 -LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIH 177 + + ++++ +E+ D+ K ++ + + E + + +++ ++++HS ++H Sbjct: 125 DVEKFDELYVVLEIADSDFKKLFRTPV----YLTELHIKTLLYNLLVGVKYVHS-AGILH 179 Query: 178 RDVKPSNVLINALGQVKMCDFGISGYLVDSV----------------------------A 209 RD+KP+N L+N VK+CDFG++ + Sbjct: 180 RDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQ 239 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA------------------ 251 T + Y APE I L Q+ Y+ D+WS+G EL Sbjct: 240 LTGHVVTRWYRAPELI---LLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFP 296 Query: 252 -ILRFP-------------------------YDSWGTPFQQ------------LKQVVEE 273 FP ++ GTP ++ ++ + Sbjct: 297 GSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPK 356 Query: 274 PSPQLPADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 A++F SA+ + + L N +R T E + HPFF Sbjct: 357 REGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFK 401 >3C1X-A nrPDB Length = 373 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 119/292 (40%), Gaps = 17/292 (5%) Query: 24 QTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVP-SGQIM--A 80 S+ P + + + IG + V ++ +GRG +G V + G+ + A Sbjct: 67 DLSALNPELVQAVQHVVIGPSSLIVHFNE-----VIGRGHFGCVYHGTLLDNDGKKIHCA 121 Query: 81 VKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR-EGDVWICMELMDTSLDKF 139 VK + + E + L + I M+ P ++ G R EG + + M + Sbjct: 122 VKSLNRITDIGEVSQFLTE-GIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRN 180 Query: 140 YKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFG 199 + + T+ L + + K ++ L SK +HRD+ N +++ VK+ DFG Sbjct: 181 FIRNETHNPTVK--DLIGFGLQVAKGMKFLASK-KFVHRDLAARNCMLDEKFTVKVADFG 237 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAI-LRFPY 257 ++ + D ++ + + + E L + ++ KSD+WS G+ + EL PY Sbjct: 238 LARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPY 297 Query: 258 DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 T + + + L + + +C ++ RP++ EL+ Sbjct: 298 PDVNT--FDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELV 347 >5TOS-A nrPDB Length = 395 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 122/307 (39%), Gaps = 35/307 (11%) Query: 33 LDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKM---------RHVPSGQIMAVKR 83 L S S ++ + P +G G +G V K +G ++AVK+ Sbjct: 47 LSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 Query: 84 IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFYKQ 142 + Q + L +++ + + P V G + + E M SL+ + Sbjct: 107 LNQEGF-QGHREWLTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR 164 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKL-SVIHRDVKPSNVLINALGQVKMCDFGIS 201 + +P + +A+ K L LHS VI+RD+K SN+L++A K+ DFG++ Sbjct: 165 RGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 Query: 202 GY--LVDSVAKTIDA-GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD 258 + D + G Y APE ++ + +SD++S G+ ++E+ + D Sbjct: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMS----SGHLNARSDVYSFGVLLLEILSGKRALD 280 Query: 259 SWGTPFQQL------------KQVVEEPSPQLPADKFSAEFVDFTS---QCLKKNSKERP 303 ++ ++V+ +L E V S QCL K RP Sbjct: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 Query: 304 TYPELMQ 310 T ++++ Sbjct: 341 TMDQVVR 347 >5TUR-A nrPDB Length = 404 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 121/300 (40%), Gaps = 27/300 (9%) Query: 24 QTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR 83 + P DL + G + E + LG G +G V V +A+K Sbjct: 102 HLRAAPCNDLHATKLAP-GKEK-EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKH 159 Query: 84 IRATVNSQEQK-----RLLMDLDISMRTVDCPF--TVTFYGALFREGDVWICMELMDTSL 136 + S + R+ M++ + ++ V F + R + +E + Sbjct: 160 VEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSGVIRLLDWFERPDSFVLILE-RPEPV 217 Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN-ALGQVKM 195 + + ++G + E++ +++A+ H H V+HRD+K N+LI+ G++K+ Sbjct: 218 QDLFDFITERG-ALQEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKL 275 Query: 196 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 DFG SG L+ T G + Y PE I + + + +WSLGI + ++ Sbjct: 276 IDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYH---RYHGRSAAVWSLGILLYDMVCGDI 331 Query: 256 PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P++ ++++ + S+E CL +RPT+ E+ HP+ Sbjct: 332 PFEHD-------EEIIRGQ--VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 382 >6BXI-A nrPDB Length = 333 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 71/309 (22%), Positives = 129/309 (41%), Gaps = 58/309 (18%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK--RLLMDLDISMRTVD 108 +D E + +GRGA+G V ++ +G + A+K +R ++++ + + DI + D Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDI-LVEAD 64 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + V + + + ++++ ME + ++ K T+ E+ V A++ Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGGD---MMTLLMKKDTLTEEETQFYIAETVLAIDS 121 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKT----------------- 211 +H +L IHRD+KP N+L+++ G VK+ DFG+ L + Sbjct: 122 IH-QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 212 -------------------IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 G Y+APE Q GY+ D WSLG+ M E+ I Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEV----FMQTGYNKLCDWWSLGVIMYEMLI 236 Query: 253 LRFPYDSWGTPFQQLKQVVE-EPSPQLPAD-KFSAEFVDFTSQ--CLKKNSKER---PTY 305 P+ S TP + K+V+ + + P + S + D + C + R P Sbjct: 237 GYPPFCSE-TPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC---EWEHRIGAPGV 292 Query: 306 PELMQHPFF 314 E+ + FF Sbjct: 293 EEIKSNSFF 301 >4HVI-A nrPDB Length = 314 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 125/286 (43%), Gaps = 36/286 (12%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVP----SGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 + L+ I +LG+G +G VE R+ P +G ++AVK+++ + +Q+ ++ I Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHS-GPDQQRDFQREIQI- 64 Query: 104 MRTVDCPFTVTFYGALFREGD--VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 ++ + F V + G + G + + ME + + + + Q + L + Sbjct: 65 LKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ--RHRARLDASRLLLYSSQ 122 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGY--LVDSVAKTIDAGCKP- 218 I K +E+L S+ +HRD+ N+L+ + VK+ DFG++ L + G P Sbjct: 123 ICKGMEYLGSR-RCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPI 181 Query: 219 -YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP- 276 + APE ++ + +S +SD+WS G+ + EL S + L+ + E Sbjct: 182 FWYAPESLSDNI----FSRQSDVWSFGVVLYELFTYCD--KSCSPSAEFLRMMGSERDVP 235 Query: 277 -------------QLP-ADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +LP AE + C + ++RP++ L Sbjct: 236 ALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >3BGP-A nrPDB Length = 333 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 121/300 (40%), Gaps = 27/300 (9%) Query: 24 QTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR 83 + P DL + G + E + LG G +G V V +A+K Sbjct: 31 HLRAAPCNDLHATKLAP-GKEK-EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKH 88 Query: 84 IRATVNSQEQK-----RLLMDLDISMRTVDCPF--TVTFYGALFREGDVWICMELMDTSL 136 + S + R+ M++ + ++ V F + R + +E + Sbjct: 89 VEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSGVIRLLDWFERPDSFVLILE-RPEPV 146 Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN-ALGQVKM 195 + + ++G + E++ +++A+ H H V+HRD+K N+LI+ G++K+ Sbjct: 147 QDLFDFITERG-ALQEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKL 204 Query: 196 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 DFG SG L+ T G + Y PE I + + + +WSLGI + ++ Sbjct: 205 IDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYH---RYHGRSAAVWSLGILLYDMVCGDI 260 Query: 256 PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 P++ ++++ + S+E CL +RPT+ E+ HP+ Sbjct: 261 PFEHD-------EEIIRGQ--VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 311 >3N9X-A nrPDB Length = 432 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 82/385 (21%), Positives = 143/385 (37%), Gaps = 101/385 (26%) Query: 40 SIGNQNFEVK-------ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQ 91 S G +N + D+ +GRG+YG V + + +A+K++ R + Sbjct: 8 SSGRENLYFQGIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLI 67 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFRE-----GDVWICMELMDTSLDKFYKQVIDK 146 + KR+L ++ I R + + + Y + + +++I +E+ D+ L K +K I Sbjct: 68 DCKRILREITILNR-LKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPI-- 124 Query: 147 GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD 206 + E+ + I +++ +H +IHRD+KP+N L+N VK+CDFG++ + Sbjct: 125 --FLTEEHIKTILYNLLLGENFIHES-GIIHRDLKPANCLLNQDCSVKVCDFGLARTINS 181 Query: 207 S-----------------------VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSL 243 T + Y APE I L Q+ Y+ DIWS Sbjct: 182 EKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELI---LLQENYTKSIDIWST 238 Query: 244 GITMIELA----------ILRFP-------------------------------YDSWGT 262 G EL RFP ++ GT Sbjct: 239 GCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGT 298 Query: 263 PFQQLKQVVEEPSP-----QLPADK----------FSAEFVDFTSQCLKKNSKERPTYPE 307 P + + + +P P K S + ++ LK N +R T + Sbjct: 299 PTEDDLKNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQ 358 Query: 308 LMQHPFFTLHESKGTDVASFVKLIL 332 + HP+ K + S K+IL Sbjct: 359 ALDHPYLKDVRKKKLENFSTKKIIL 383 >5HVK-A nrPDB Length = 315 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 115/279 (41%), Gaps = 25/279 (8%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107 + DL LG+G +G K+ H +G++M +K + + + Q+ L ++ + MR + Sbjct: 11 FRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL-IRFDEETQRTFLKEVKV-MRCL 68 Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + P + F G L+++ + E + + + +D P A I + Sbjct: 69 EHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDS--QYPWSQRVSFAKDIASGMA 126 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA---------------KTI 212 +LHS +++IHR++ N L+ V + DFG++ +VD + Sbjct: 127 YLHS-MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT 185 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G +MAPE IN + Y K D++S GI + E+ + V Sbjct: 186 VVGNPYWMAPEMING----RSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVR 241 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + F T +C + ++RP++ + ++H Sbjct: 242 GFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVK-LEH 279 >4C59-A nrPDB Length = 340 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 116/299 (38%), Gaps = 30/299 (10%) Query: 34 DSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ 93 + Q E+ L L G + V + + V SG+ A+KR+ + + + Sbjct: 10 SGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNR 69 Query: 94 KRLLMDLDISMRTVDCPFTVTF--------YGALFREGDVWICMELMDTSLDKFYKQVID 145 ++ ++ + P V F + + + + EL L +F K++ Sbjct: 70 A-IIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMES 128 Query: 146 KGQTIPEDILGKIAVSIVKALEHLH-SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 +G + D + KI +A++H+H K +IHRD+K N+L++ G +K+CDFG + + Sbjct: 129 RG-PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTI 187 Query: 205 VDSVAKT-------------IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA 251 + Y PE I+ N K DIW+LG + L Sbjct: 188 SHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNF-PIGEKQDIWALGCILYLLC 246 Query: 252 ILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + P++ ++V P D F L+ N +ER + E++ Sbjct: 247 FRQHPFEDGAK-----LRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVH 300 >4M7I-A nrPDB Length = 299 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 130/292 (44%), Gaps = 41/292 (14%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D EPI LGRG +GVV + ++ A+KRIR +++++ ++ ++ ++ P Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVK-ALAKLEHP 63 Query: 111 FTVTFYGALFREG------------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILG-- 156 V ++ A + ++I M+L + K ++ TI E Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRK---ENLKDWMNGRCTIEERERSVC 120 Query: 157 -KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK----- 210 I + I +A+E LHSK ++HRD+KPSN+ VK+ DFG+ + + Sbjct: 121 LHIFLQIAEAVEFLHSK-GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 211 --------TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262 T G K YM+PE+I + YS K DI+SLG+ + EL +P+ + Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQI----HGNSYSHKVDIFSLGLILFELL---YPFSTQME 232 Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 + L V P L K+ E+V L + ERP ++++ F Sbjct: 233 RVRTLTDVRNLKFPPLFTQKYPCEYV-MVQDMLSPSPMERPEAINIIENAVF 283 >3EB0-A nrPDB Length = 383 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 129/336 (38%), Gaps = 77/336 (22%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 E + LG G++G+V ++ + SG+ A+K++ + +LDI M+ Sbjct: 2 LETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-----RELDI-MK 55 Query: 106 TVDCPFTVTFYGALFREGD--------------------------------------VWI 127 +D + + GD + + Sbjct: 56 VLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNV 115 Query: 128 CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187 ME + +L K K I G++IP +++ + +A+ +HS L + HRD+KP N+L+ Sbjct: 116 IMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHS-LGICHRDIKPQNLLV 174 Query: 188 NA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGIT 246 N+ +K+CDFG + L+ S + Y APE + L Y+ D+WS+G Sbjct: 175 NSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELM---LGATEYTPSIDLWSIGCV 231 Query: 247 MIELAILRFPYDSWGTPFQQLKQVVE---------------------------EPSPQLP 279 EL + + P S T QL ++++ + ++ Sbjct: 232 FGELILGK-PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKIL 290 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 + + +D Q L+ R E M HPFF Sbjct: 291 PEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFD 326 >1ZXE-A nrPDB Length = 303 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 128/312 (41%), Gaps = 44/312 (14%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 A D E I LG+GA+G V K R+ + A+K+IR T ++ +L ++ + + +++ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHT--EEKLSTILSEV-MLLASLNH 61 Query: 110 PFTVTFYGALFREGD-------------VWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 + V +Y A + ++I ME + Y + + D Sbjct: 62 QYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCEN--RTLYDLIHSENLNQQRDEYW 119 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV----------- 205 ++ I++AL ++HS+ +IHR++KP N+ I+ VK+ DFG++ + Sbjct: 120 RLFRQILEALSYIHSQ-GIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQ 178 Query: 206 ----DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG 261 S T G Y+A E ++ Y+ K D++SLGI E+ +P+ + Sbjct: 179 NLPGSSDNLTSAIGTAMYVATEVLD---GTGHYNEKIDMYSLGIIFFEMI---YPFSTGM 232 Query: 262 TPFQQLKQVVEEPSPQLPADKFSAEF---VDFTSQCLKKNSKERPTYPELMQHPFFTLHE 318 LK+ + S + P D + + + +RP L+ + + Sbjct: 233 ERVNILKK-LRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWLPVKH 291 Query: 319 SKGTDVASFVKL 330 + L Sbjct: 292 QDEVIKEALKSL 303 >3DLS-A nrPDB Length = 335 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 107/273 (39%), Gaps = 23/273 (8%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLLMDLDI 102 + + LG GA+G V + + VK I+ + + ++ +++ I Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 R V+ + +G + ME + LD F ID+ + E + I + Sbjct: 83 LSR-VEHANIIKVLDIFENQGFFQLVMEKHGSGLDLF--AFIDRHPRLDEPLASYIFRQL 139 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 V A+ +L K +IHRD+K N++I +K+ DFG + YL G Y AP Sbjct: 140 VSAVGYLRLK-DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAP 198 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E + + + ++WSLG+T+ L P+ + P Sbjct: 199 EVL---MGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIH---------PPYL 246 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 S E + S L+ + R T +L+ P+ T Sbjct: 247 VSKELMSLVSGLLQPVPERRTTLEKLVTDPWVT 279 >5WNL-A nrPDB Length = 342 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 20/263 (7%) Query: 57 MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFY 116 ++G G +G V K+RHV +A+K + ++ L++ M + + Y Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 117 GALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS-KLS 174 G V + ME M+ SL+K + +P D+ +I + LH Sbjct: 86 GICQE--PVGLVMEYMETGSLEKLL-----ASEPLPWDLRFRIVHETAVGMNFLHCMSPP 138 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISG----YLVDSVAKTIDAGCKPYMAPERINPELN 230 ++H ++KP+N+L++A VK+ DFG++ ++ G Y+ PERI Sbjct: 139 LLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE--K 196 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA-----DKFSA 285 + + K D++S I + + + P+ + +VV+ P+LP + A Sbjct: 197 SRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACA 256 Query: 286 EFVDFTSQCLKKNSKERPTYPEL 308 + +C + + RPT+ E+ Sbjct: 257 SLIGLMQRCWHADPQVRPTFQEI 279 >4RC3-A nrPDB Length = 289 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 113/273 (41%), Gaps = 25/273 (9%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK-----RLLMDLDISMR 105 + LG G +G V V +A+K + S + R+ M++ + ++ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV-VLLK 70 Query: 106 TVDCPF--TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 V F + R + +E + + + ++G + E++ ++ Sbjct: 71 KVSSGFSGVIRLLDWFERPDSFVLILE-RPEPVQDLFDFITERG-ALQEELARSFFWQVL 128 Query: 164 KALEHLHSKLSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 +A+ H H V+HRD+K N+LI+ G++K+ DFG SG L+ T G + Y P Sbjct: 129 EAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPP 186 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E I + + + +WSLGI + ++ P++ ++++ + Sbjct: 187 EWIRYH---RYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQ--VFFRQR 234 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 S+E CL +RPT+ E+ HP+ Sbjct: 235 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 267 >4YFF-A nrPDB Length = 311 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 108/272 (39%), Gaps = 15/272 (5%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT--VNSQEQKRLLMDLD 101 +F ++ ++E +G G++G V K R +I+A+KR RA + + ++ Sbjct: 35 SHFHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVS 92 Query: 102 ISMRTVDCPFTVTFYGALF-REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 I ++ P + F GA I + + + + ++ + + IAV Sbjct: 93 ILC-QLNHPCVIQFVGACLNDPSQFAIVTQYISGG--SLFSLLHEQKRILDLQSKLIIAV 149 Query: 161 SIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCK 217 + K +E+LH+ +IHRD+ N+L+ G + DFG S +L D T G Sbjct: 150 DVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNL 209 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 +MAPE Y++K+D++S + + E+ P+ P Sbjct: 210 RWMAPEVFT---QCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPP 266 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + + RP + E++ Sbjct: 267 I-GYSIPKPISSLLIRGWNACPEGRPEFSEVV 297 >3M42-A nrPDB Length = 299 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 64/283 (22%), Positives = 109/283 (38%), Gaps = 48/283 (16%) Query: 51 DDLEP-IMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 DD + LG G G V ++ + + + A+K + Q+ + ++++ R C Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQC 70 Query: 110 PFTVTFYGALFR----EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVK 164 P V + I ME +D + + ++ D+G Q E +I SI + Sbjct: 71 PHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINA---LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 A+++LHS +++ HRDVKP N+L + +K+ DFG + Sbjct: 129 AIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAK------------------- 168 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLP 279 E + Y D+WSLG+ M L P+ S +K + + P Sbjct: 169 ------ETTGEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 222 Query: 280 ADKF---SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES 319 ++ S E LK +R T E M HP+ Sbjct: 223 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 265 >2I6L-A nrPDB Length = 320 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 122/315 (38%), Gaps = 59/315 (18%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 + LG G G+V + +A+K+I + Q K L ++ I R +D Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI-VLTDPQSVKHALREIKII-RRLDHD 68 Query: 111 FTVTFY--------------GALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 V + G+L V+I E M+T L +Q + E+ Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQ-----GPLLEEHAR 123 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAK----T 211 +++ L+++HS +V+HRD+KP+N+ IN +K+ DFG++ + + + Sbjct: 124 LFMYQLLRGLKYIHS-ANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 182 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 K Y +P + L+ Y+ D+W+ G E+ + + +Q++ ++ Sbjct: 183 EGLVTKWYRSPRLL---LSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHE-LEQMQLIL 238 Query: 272 EEPSPQLPADK----------------------------FSAEFVDFTSQCLKKNSKERP 303 E D+ S E VDF Q L + +R Sbjct: 239 ESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRL 298 Query: 304 TYPELMQHPFFTLHE 318 T E + HP+ +++ Sbjct: 299 TAEEALSHPYMSIYS 313 >3HNG-A nrPDB Length = 360 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 69/341 (20%), Positives = 121/341 (35%), Gaps = 80/341 (23%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKM-----RHVPSGQIMAVKRIRATVNSQEQKRLLM 98 +E + L+ LGRGA+G V + + P+ + +AVK ++ + E K L+ Sbjct: 20 SKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMT 79 Query: 99 DLDISMRTVDCPF-----------------TVTF-------------YGALFREGDVWIC 128 +L I V + F D + Sbjct: 80 ELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALH 139 Query: 129 MEL----MDTSLDKFYKQVIDK-------------------------------GQTIPED 153 ME M+ L++ K +D + I + Sbjct: 140 MEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITME 199 Query: 154 ILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID 213 L + + + +E L S IHRD+ N+L++ VK+CDFG++ + + Sbjct: 200 DLISYSFQVARGMEFL-SSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRK 258 Query: 214 AGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQ 269 + +MAPE I ++ YS KSD+WS G+ + E+ PY + Sbjct: 259 GDTRLPLKWMAPESIFDKI----YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMD-EDFCS 313 Query: 270 VVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + E + + E C ++ KERP + EL++ Sbjct: 314 RLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVE 354 >5LPZ-A nrPDB Length = 332 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 119/299 (39%), Gaps = 28/299 (9%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 +G G +G V K G +A+K++ V+ Q + + +++ ++ + Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIH-VSGQGDREFMAEME-TIGKIKHRNL 75 Query: 113 VTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V G + + E M SL+ G + KIA+ + L LH Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 172 KL--SVIHRDVKPSNVLINALGQVKMCDFGISGY---LVDSVAKTIDAGCKPYMAPERIN 226 +IHRD+K SNVL++ + ++ DFG++ + ++ + AG Y+ PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY- 194 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 S K D++S G+ ++EL + P DS L V++ + +D F E Sbjct: 195 ---QSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPE 251 Query: 287 F--------VDFTSQ------CLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLI 331 ++ CL + RPT ++M F + G D S ++ I Sbjct: 252 LMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAM-FKEIQAGSGIDSQSTIRSI 309 >2A1A-B nrPDB Length = 284 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 123/275 (44%), Gaps = 35/275 (12%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 D + I +G G +G V K +H G+ +KR++ ++ ++ ++ +D Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-----NNEKAEREVK-ALAKLDHVN 65 Query: 112 TVTFYGAL----------------FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL 155 V + G + ++I ME D + + + +G+ + + + Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIE-KRRGEKLDKVLA 124 Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAG 215 ++ I K ++++HSK +I+RD+KPSN+ + QVK+ DFG+ L + +T G Sbjct: 125 LELFEQITKGVDYIHSK-KLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKG 183 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 YM+PE+I+ + Y + D+++LG+ + EL + F L+ + Sbjct: 184 TLRYMSPEQIS----SQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGI---- 235 Query: 276 PQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 +D F + + L K ++RP E+++ Sbjct: 236 ---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >3NIE-A nrPDB Length = 429 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 81/390 (20%), Positives = 145/390 (37%), Gaps = 106/390 (27%) Query: 40 SIGNQNFEVK---------ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVN 89 S G +N + D+ E +GRG+YG V + + +A+K++ R + Sbjct: 8 SSGRENLYFQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFED 67 Query: 90 SQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG-----DVWICMELMDTSLDKFYKQVI 144 + KR+L ++ I R + + + + + E +++I +E+ D+ L K +K I Sbjct: 68 LIDCKRILREITILNR-LKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPI 126 Query: 145 DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL 204 + E + I +++ + +H +IHRD+KP+N L+N VK+CDFG++ + Sbjct: 127 ----FLTEQHVKTILYNLLLGEKFIHES-GIIHRDLKPANCLLNQDCSVKICDFGLARTI 181 Query: 205 VDS--------------------------VAKTIDAGCKPYMAPERINPELNQKGYSVKS 238 T + Y APE I L Q+ Y+ Sbjct: 182 NSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELI---LLQENYTNSI 238 Query: 239 DIWSLGITMIELA----------ILRFP-------------------------------Y 257 DIWS G EL RFP + Sbjct: 239 DIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIF 298 Query: 258 DSWGTPFQQLKQVVEEPSP-----QLPADK----------FSAEFVDFTSQCLKKNSKER 302 + GTP ++ + + + P S E +D L+ N+++R Sbjct: 299 NVIGTPPEEDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKR 358 Query: 303 PTYPELMQHPFFTLHESKGTDVASFVKLIL 332 T + + HP+ + + S K+IL Sbjct: 359 ITIDKALSHPYLKDVRKENLENFSTEKIIL 388 >2WTK-C nrPDB Length = 305 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 110/270 (40%), Gaps = 17/270 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN---SQEQKRLLMDLDISMRTVDC 109 LG G+YG V+++ + AVK ++ + + ++ +R + Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQ-LLRRLRH 65 Query: 110 PFTVTFYGALFREGD--VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + L+ E +++ ME + + V +K P ++ LE Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKR--FPVCQAHGYFCQLIDGLE 123 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD---SVAKTIDAGCKPYMAPER 224 +LHS+ ++H+D+KP N+L+ G +K+ G++ L G + PE Sbjct: 124 YLHSQ-GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEI 182 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS 284 N G+ K DIWS G+T+ + +P++ G +L + + + S +P D Sbjct: 183 ANGLDTFSGF--KVDIWSAGVTLYNITTGLYPFE--GDNIYKLFENIGKGSYAIPGD-CG 237 Query: 285 AEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 D L+ +R + ++ QH +F Sbjct: 238 PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF 267 >1TKI-A nrPDB Length = 321 Score = 194 bits (493), Expect = 6e-50, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 106/270 (39%), Gaps = 17/270 (6%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 + +LGRG +G+V + S + K ++ V +Q + ++ I + Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK--VKGTDQVLVKKEISI-LNIARHR 61 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 + + + ++ + E + ++++ + E + + +AL+ LH Sbjct: 62 NILHLHESFESMEELVMIFEFISG--LDIFERINTSAFELNEREIVSYVHQVCEALQFLH 119 Query: 171 SKLSVIHRDVKPSNVLINAL--GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 S ++ H D++P N++ +K+ +FG + L + Y APE Sbjct: 120 SH-NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEV---- 174 Query: 229 LNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKF---SA 285 S +D+WSLG + L P+ QQ+ + + + F S Sbjct: 175 HQHDVVSTATDMWSLGTLVYVLLSGINPF--LAETNQQIIENIMNAEYTFDEEAFKEISI 232 Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 E +DF + L K K R T E +QHP+ Sbjct: 233 EAMDFVDRLLVKERKSRMTASEALQHPWLK 262 >5UIU-A nrPDB Length = 323 Score = 193 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 106/271 (39%), Gaps = 27/271 (9%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN---SQEQKRLLMDLDISMRTVDCPFTVT 114 ++G G +GVV K + +AVK++ A V+ + +++ ++ + M V Sbjct: 54 KMGEGGFGVVYKGY--VNNTTVAVKKLAAMVDITTEELKQQFDQEIKV-MAKCQHENLVE 110 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G D+ + M +D + + KIA + LH Sbjct: 111 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISG---YLVDSVAKTIDAGCKPYMAPERINPELNQ 231 + HRD+K +N+L++ K+ DFG++ +V + G YMAPE + E+ Sbjct: 171 I-HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-- 227 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE-----------PSPQLPA 280 + KSDI+S G+ ++E+ D P L E A Sbjct: 228 ---TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDA 284 Query: 281 DKFSAE-FVDFTSQCLKKNSKERPTYPELMQ 310 D S E SQCL + +RP ++ Q Sbjct: 285 DSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >5Y86-A nrPDB Length = 588 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 70/336 (20%), Positives = 123/336 (36%), Gaps = 76/336 (22%) Query: 46 FEVKAD----DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVN----SQEQKRLL 97 V D E + +G+G++G V ++ Q +A+K +R + E+ R+L Sbjct: 198 IHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 Query: 98 MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 L +T + + V + EL+ L + K+ +K Q ++ K Sbjct: 258 EHLKKQDKTGSM-NVIHMLESFTFRNHVCMAFELLSIDLYELIKK--NKFQGFSVQLVRK 314 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAG 215 A SI+++L+ LH K +IH D+KP N+L+ G+ K+ DFG S + + I Sbjct: 315 FAQSILQSLDALH-KNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-- 371 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------------WGT 262 + Y APE I YS DIWS G + EL + + G Sbjct: 372 SRFYRAPEIILGS----RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 Query: 263 PFQQLKQVVEEPSPQLPADKFSAE------------------------------------ 286 P +L + + + + Sbjct: 428 PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 Query: 287 -------FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 F++F +CL + R T + ++HP+ + Sbjct: 488 KGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 >3QA8-A nrPDB Length = 676 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 98/230 (42%), Gaps = 15/230 (6%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 E LG G +G V + H +G+ +A+K+ R ++ + ++R +++ I M+ ++ P Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQI-MKKLNHPNV 74 Query: 113 VTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V+ L + ME + + Y + + E + + I AL Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQV---KMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 +LH +IHRD+KP N+++ Q K+ D G + L T G Y+APE Sbjct: 135 RYLHEN-RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE 273 L QK Y+V D WS G E P+ P Q +V E+ Sbjct: 194 L----LEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREK 239 >3PG1-A nrPDB Length = 362 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 111/307 (36%), Gaps = 55/307 (17%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQE----------QKRLLMDLDI 102 + G+YG V G +A+KR+ TV+ KR+L ++ Sbjct: 24 YTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIR- 81 Query: 103 SMRTVDCPFTVTFYGALFREGD-----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 + P + + +++ ELM T L + D+ I + Sbjct: 82 LLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIH---DQRIVISPQHIQY 138 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217 I+ L LH V+HRD+ P N+L+ + +CDF ++ KT + Sbjct: 139 FMYHILLGLHVLHE-AGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHR 197 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 Y APE + + KG++ D+WS G M E+ + + T + QL ++VE Sbjct: 198 WYRAPELV---MQFKGFTKLVDMWSAGCVMAEMFNRKALFR-GSTFYNQLNKIVEVVGTP 253 Query: 278 LPADKF------------------------------SAEFVDFTSQCLKKNSKERPTYPE 307 D +D ++ L+ N + R + + Sbjct: 254 KIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQ 313 Query: 308 LMQHPFF 314 ++HP+F Sbjct: 314 ALRHPYF 320 >3ORP-A nrPDB Length = 311 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 112/283 (39%), Gaps = 22/283 (7%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTV 107 +D E LG G V R + + +AVK +RA + R + + + Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNA-AAL 69 Query: 108 DCPFTVTFYGALFREGDV----WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + P V Y E +I ME +D + ++ + ++ Sbjct: 70 NHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVT---LRDIVHTEGPMTPKRAIEVIADAC 126 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDA----GCKPY 219 +AL H +IHRDVKP+N++I+A VK+ DFGI+ + DS G Y Sbjct: 127 QALNFSHQN-GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQY 185 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEP-SPQL 278 ++PE + +SD++SLG + E+ P+ + V E+P P Sbjct: 186 LSPE----QARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSA 241 Query: 279 PADKFSAEFVDFTSQCLKKNSKERP-TYPELMQHPFFTLHESK 320 + SA+ + L KN + R T E M+ +H + Sbjct: 242 RHEGLSADLDAVVLKALAKNPENRYQTAAE-MRADLVRVHNGE 283 >3UIU-A nrPDB Length = 306 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 123/288 (42%), Gaps = 48/288 (16%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 D + I +G G +G V K +H G+ ++R++ ++ ++ ++ +D Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKY-----NNEKAEREVK-ALAKLDHVN 66 Query: 112 TVTFYGAL-----------------------------FREGDVWICMELMDTSLDKFYKQ 142 V + G + ++I ME D + + + Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG 202 +G+ + + + ++ I K ++++HSK +IHRD+KPSN+ + QVK+ DFG+ Sbjct: 127 -KRRGEKLDKVLALELFEQITKGVDYIHSK-KLIHRDLKPSNIFLVDTKQVKIGDFGLVT 184 Query: 203 YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT 262 L + +T G YM+PE+I+ + Y + D+++LG+ + EL + Sbjct: 185 SLKNDGKRTRSKGTLRYMSPEQIS----SQDYGKEVDLYALGLILAELLHVCDTAFETSK 240 Query: 263 PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 F L+ + +D F + + L K ++RP E+++ Sbjct: 241 FFTDLRDGI-------ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >5LPV-A nrPDB Length = 296 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 111/278 (39%), Gaps = 27/278 (9%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 +G G +G V K G +A+K++ V+ Q + + +++ ++ + Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIH-VSGQGDREFMAEME-TIGKIKHRNL 75 Query: 113 VTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V G + + E M SL+ G + KIA+ + L LH Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 172 KL--SVIHRDVKPSNVLINALGQVKMCDFGISGY---LVDSVAKTIDAGCKPYMAPERIN 226 +IHRD+K SNVL++ + ++ DFG++ + ++ + AG Y+ PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY- 194 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 S K D++S G+ ++EL + P DS L V++ + +D F E Sbjct: 195 ---QSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPE 251 Query: 287 F--------VDFTSQ------CLKKNSKERPTYPELMQ 310 ++ CL + RPT ++M Sbjct: 252 LMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMA 289 >3UIM-A nrPDB Length = 326 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 60/312 (19%), Positives = 122/312 (39%), Gaps = 29/312 (9%) Query: 20 FEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM 79 F P L S+ + +V +D+ LGRG +G V K R + G ++ Sbjct: 1 FFDVPAEEDPEVHLGQLKRFSL--RELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLV 57 Query: 80 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDK 138 AVKR++ + + ++++ V + G + + M + S+ Sbjct: 58 AVKRLKEERTQGGELQFQTEVEMISMAV-HRNLLRLRGFCMTPTERLLVYPYMANGSVAS 116 Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL--SVIHRDVKPSNVLINALGQVKMC 196 ++ + + +IA+ + L +LH +IHRDVK +N+L++ + + Sbjct: 117 CLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVG 176 Query: 197 DFGISGYLV--DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 254 DFG++ + D+ T G ++APE ++ + S K+D++ G+ ++EL + Sbjct: 177 DFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKS----SEKTDVFGYGVMLLELITGQ 232 Query: 255 FPYDSWGTPFQQLKQVVEEPSPQLPADKF-------------SAEFVDFTS---QCLKKN 298 +D +++ L K E C + + Sbjct: 233 RAFDLARLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSS 292 Query: 299 SKERPTYPELMQ 310 ERP E+++ Sbjct: 293 PMERPKMSEVVR 304 >5X8I-B nrPDB Length = 346 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 75/338 (22%), Positives = 124/338 (36%), Gaps = 75/338 (22%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 Q+ +V + E + LG GA+G V + H G+ +AVK ++ E R + + Sbjct: 6 QSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLE 65 Query: 103 SMRTVDCPF----TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 + T D P V G + I EL+ S F K+ + D + K+ Sbjct: 66 HLNTTD-PNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE--NGFLPFRLDHIRKM 122 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINA-------------------LGQVKMCDFG 199 A I K++ LHS + H D+KP N+L +K+ DFG Sbjct: 123 AYQICKSVNFLHSN-KLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG 181 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 + Y D + + Y APE I G+S D+WS+G +IE + + + Sbjct: 182 SATY--DDEHHSTLVSTRHYRAPEVILA----LGWSQPCDVWSIGCILIEYYLGFTVFPT 235 Query: 260 WGTPFQ-QLKQVVEEPSP----------------QLPADKFSAE---------------- 286 + + + + P P +L D+ S+ Sbjct: 236 HDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFML 295 Query: 287 --------FVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 D + L+ + +R T E ++HPFF L Sbjct: 296 SQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 333 >5ZTN-A nrPDB Length = 429 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 72/330 (21%), Positives = 120/330 (36%), Gaps = 70/330 (21%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 E + +G+G++G V K Q +A+K +R Q + + +R D Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN 157 Query: 112 ---TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 + + + EL+ +L + K+ +K Q ++ K A SI++ L+ Sbjct: 158 TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK--NKFQGFSLPLVRKFAHSILQCLDA 215 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 LH K +IH D+KP N+L+ G+ +K+ DFG S Y V I + Y APE I Sbjct: 216 LH-KNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQ--SRFYRAPEVIL 272 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRF--PYDSWGT-----------PFQQLKQVVEE 273 Y + D+WSLG + EL P + G P Q+L + Sbjct: 273 GA----RYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKR 328 Query: 274 PSPQLPADKFS-------------------------------------------AEFVDF 290 + + + F+DF Sbjct: 329 AKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDF 388 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESK 320 QCL+ + R T + ++HP+ K Sbjct: 389 LKQCLEWDPAVRMTPGQALRHPWLRRRLPK 418 >4X7Q-B nrPDB Length = 312 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 107/273 (39%), Gaps = 25/273 (9%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS-----QEQKRLLMDLDISMR- 105 + LG+G +G V + +A+K I + +++ + + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 106 --TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 P + + + +E + + +KG + E +V Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLE-RPLPAQDLFDYITEKG-PLGEGPSRCFFGQVV 149 Query: 164 KALEHLHSKLSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 222 A++H HS+ V+HRD+K N+LI+ G K+ DFG SG L+ T G + Y P Sbjct: 150 AAIQHCHSR-GVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGTRVYSPP 207 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E I+ + +++ + +WSLGI + ++ P++ Q + E PA Sbjct: 208 EWISRH---QYHALPATVWSLGILLYDMVCGDIPFER--------DQEILEAELHFPA-H 255 Query: 283 FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 S + +CL RP+ E++ P+ Sbjct: 256 VSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >2Y4I-B nrPDB Length = 319 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 128/307 (41%), Gaps = 25/307 (8%) Query: 15 IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVP 74 P+ S P + + SI Q +++ + LE +G+G +G V R Sbjct: 1 GPEMNLSLLSARSFPRKASQT----SIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG 56 Query: 75 SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT 134 +A++ I ++++Q + ++ R V F GA + I L Sbjct: 57 ---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKG 113 Query: 135 SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVK 194 Y V D + + +IA IVK + +LH+K ++H+D+K NV + G+V Sbjct: 114 --RTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK-GILHKDLKSKNVFYD-NGKVV 169 Query: 195 MCDFGI---SGYLV---DSVAKTIDAGCKPYMAPERI-----NPELNQKGYSVKSDIWSL 243 + DFG+ SG L I G ++APE I + E ++ +S SD+++L Sbjct: 170 ITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFAL 229 Query: 244 GITMIELAILRFPYDSWGTPFQQLK-QVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKER 302 G EL +P+ + P + + Q+ P L E D C +ER Sbjct: 230 GTIWYELHAREWPFKT--QPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEER 287 Query: 303 PTYPELM 309 PT+ +LM Sbjct: 288 PTFTKLM 294 >4KIK-B nrPDB Length = 677 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 106/282 (37%), Gaps = 36/282 (12%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 E LG G +G V + + +G+ +A+K+ R ++ + ++R +++ I MR + P Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQI-MRRLTHPNV 79 Query: 113 VTFYGALFREGDV------WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V ++ + ME + Y + + E + + I AL Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQV---KMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 +LH +IHRD+KP N+++ Q K+ D G + L T G Y+APE Sbjct: 140 RYLHEN-RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE 198 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE---------- 273 L Q+ Y+V D WS G E P+ P Q +V ++ Sbjct: 199 L----LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSED 254 Query: 274 -----------PSPQLPADKFSAEFVDFTSQCLKKNSKERPT 304 P P + + L + ++R T Sbjct: 255 LNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >2RIO-A nrPDB Length = 434 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 127/304 (41%), Gaps = 34/304 (11%) Query: 45 NFEVKADDLEPIMEL-GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 NFE +L ++ G G+ G V + G+ +AVKR+ LM++ + Sbjct: 8 NFEQSLKNLVVSEKILGYGSSGTVV-FQGSFQGRPVAVKRMLIDFCDI----ALMEIKLL 62 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFY--KQVIDKGQTI-PEDILGKIAV 160 + D P + +Y + + ++I +EL + +L K V D+ + E + Sbjct: 63 TESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLR 122 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLIN-------------ALGQVKMCDFGISGYLVDS 207 I + HLHS L +IHRD+KP N+L++ ++ + DFG+ L Sbjct: 123 QIASGVAHLHS-LKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSG 181 Query: 208 VAK-----TIDAGCKPYMAPERINPELN---QKGYSVKSDIWSLGITMIELAI-LRFPY- 257 + +G + APE + N ++ + DI+S+G + + P+ Sbjct: 182 QSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFG 241 Query: 258 DSWGTPFQQLKQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 D + ++ + + D+ AE D SQ + + +RPT ++++HP F Sbjct: 242 DKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWP 301 Query: 317 HESK 320 K Sbjct: 302 KSKK 305 >6O6Q-A nrPDB Length = 335 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 120/304 (39%), Gaps = 51/304 (16%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 ++ E + +LGRG Y V + + + +K ++ ++K++ ++ I VD Sbjct: 39 PQENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPV----KRKKIKREISILKNLVD 94 Query: 109 CPFTVTFYGALFRE--GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 P + + + E ++ + T + + ++KAL Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL------YPTFTDYDIRFYMYELLKAL 148 Query: 167 EHLHSKLSVIHRDVKPSNVLINALGQV-KMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 ++ HS + ++HRDVKP NV+I+ ++ ++ D+G++ Y + + + PE + Sbjct: 149 DYSHS-MGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELL 207 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE------------- 272 ++ + Y D+WS G + + ++ P+ + QL Q+V Sbjct: 208 ---VDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEK 264 Query: 273 ---------------------EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + D S EF+D + L+ + +ER T E M+H Sbjct: 265 YNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 Query: 312 PFFT 315 +F Sbjct: 325 AYFD 328 >2BUJ-A nrPDB Length = 317 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 112/290 (38%), Gaps = 26/290 (8%) Query: 42 GNQNFEVKA-------DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK 94 G +N + I +LG G + V+ + + G A+KRI Q+++ Sbjct: 13 GRENLYFQGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI-LCHEQQDRE 71 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREG----DVWICMELMDTS-LDKFYKQVIDKGQT 149 + D+ R + P + RE + W+ + L +++ DKG Sbjct: 72 EAQREADM-HRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNF 130 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI--------- 200 + ED + + + I + LE +H+K HRD+KP+N+L+ GQ + D G Sbjct: 131 LTEDQILWLLLGICRGLEAIHAK-GYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVE 189 Query: 201 -SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 S + Y APE + + + ++D+WSLG + + PYD Sbjct: 190 GSRQALTLQDWAAQRCTISYRAPELFSVQ-SHCVIDERTDVWSLGCVLYAMMFGEGPYDM 248 Query: 260 WGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + V+ + + S+ + + + +RP P L+ Sbjct: 249 VFQKGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 >3LMG-A nrPDB Length = 344 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 112/269 (41%), Gaps = 19/269 (7%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQ----IMAVKRIRATVNSQEQKRLLMDLDIS 103 K +L + LG G +G V K +P G+ + +K I + ++ + + D ++ Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVI-EDKSGRQSFQAVTDHMLA 86 Query: 104 MRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 + ++D V G + + + + L V + +L V I Sbjct: 87 IGSLDHAHIVRLLGLC-PGSSLQLVTQYLP--LGSLLDHVRQHRGALGPQLLLNWGVQIA 143 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK--TIDAGCK-PYM 220 K + +L ++HR++ NVL+ + QV++ DFG++ L + +A +M Sbjct: 144 KGMYYLEEH-GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWM 202 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLP 279 A E I + Y+ +SD+WS G+T+ EL PY G ++ ++E+ Sbjct: 203 ALESI----HFGKYTHQSDVWSYGVTVWELMTFGAEPYA--GLRLAEVPDLLEKGERLAQ 256 Query: 280 ADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + +C + RPT+ EL Sbjct: 257 PQICTIDVYMVMVKCWMIDENIRPTFKEL 285 >4TPT-A nrPDB Length = 303 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 113/278 (40%), Gaps = 31/278 (11%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 DL LG+G +G K+ H +G++M +K + + + QK L ++ + MR++D P Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKEL-IRCDEETQKTFLTEVKV-MRSLDHPN 58 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + F G L+++ + + E ++ K + + +D P + A I + +LHS Sbjct: 59 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD---PFPWQQKVRFAKGIASGMAYLHS 115 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV---------------------DSVAK 210 + +IHRD+ N LI V + DFG+S +V D + Sbjct: 116 -MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 G +MAPE LN K Y DI+S GI + E+ + Sbjct: 175 YTVVGNPYWMAPEM----LNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLN 230 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 V+ + F + C + + RP + +L Sbjct: 231 VKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 268 >6FYV-A nrPDB Length = 337 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 73/338 (21%), Positives = 121/338 (35%), Gaps = 75/338 (22%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 Q+ +V E + LG GA+G V + H G +AVK ++ +E R + + Sbjct: 7 QSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLE 66 Query: 103 SMRTVDCPF----TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 + + D P V G V I EL+ S F K+ + D + ++ Sbjct: 67 HLNSTD-PNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE--NSFLPFQIDHIRQM 123 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLIN-------------------ALGQVKMCDFG 199 A I +++ LH + H D+KP N+L +K+ DFG Sbjct: 124 AYQICQSINFLHHN-KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG 182 Query: 200 ISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 + Y D + + Y APE I G+S D+WS+G +IE + + + Sbjct: 183 SATY--DDEHHSTLVSTRHYRAPEVILA----LGWSQPCDVWSIGCILIEYYLGFTVFQT 236 Query: 260 WGTPFQ-QLKQVVEEPSPQ----------------------------------------L 278 + + + + P PQ L Sbjct: 237 HDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFML 296 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 D+ + D + L+ + +R T E +QHPFF L Sbjct: 297 CHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 334 >5TQX-A nrPDB Length = 655 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 103/280 (36%), Gaps = 37/280 (13%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 E LG G +G V +H +A+K R ++++ ++R ++ I M+ ++ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQI-MKKLNHANV 68 Query: 113 VTFYGA------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V L + + + ME + + + E + + I + Sbjct: 69 VKACDVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGI 127 Query: 167 EHLHSKLSVIHRDVKPSNVLI-NALGQV--KMCDFGISGYLVDSVAKTIDAGCKPYMAPE 223 +LH +IHRD+KP N+++ + G++ K+ D G + + T G Y+APE Sbjct: 128 RYLHEN-KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE 186 Query: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEE-PSPQLPADK 282 K Y+ D WS G + E P+ PF +++ ++ P ++ Sbjct: 187 LFE----NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEE 242 Query: 283 FSAEFV------------DFT--------SQCLKKNSKER 302 S E L + ++R Sbjct: 243 MSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >4FL3-A nrPDB Length = 635 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 118/296 (39%), Gaps = 23/296 (7%) Query: 23 PQTSSTPPR----DLDSKACISIGNQNFEVKADDLEPI-MELGRGAYGVVEKMRH--VPS 75 PQ + P + I + + L ELG G +G V+K + Sbjct: 336 PQREALPMDTEVFESPFADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKV 395 Query: 76 GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTS 135 + +AVK ++ N K L+ M+ +D P+ V G E + + ME+ + Sbjct: 396 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELG 454 Query: 136 LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKM 195 + + + + + + + ++ + +++L + + +HRD+ NVL+ K+ Sbjct: 455 ---PLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESNFVHRDLAARNVLLVTQHYAKI 510 Query: 196 CDFGISGYL-VDSVAKTIDAGCKP---YMAPERINPELNQKGYSVKSDIWSLGITMIE-L 250 DFG+S L D K + APE I N +S KSD+WS G+ M E Sbjct: 511 SDFGLSKALRADENYYKAQTHGKWPVKWYAPECI----NYYKFSSKSDVWSFGVLMWEAF 566 Query: 251 AILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYP 306 + + PY G ++ ++E+ E D + C + + RP + Sbjct: 567 SYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFA 620 >4EQM-A nrPDB Length = 294 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 113/288 (39%), Gaps = 17/288 (5%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVD 108 + + + +LG G V +A+K I +E+ KR ++ + + Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVH-NSSQLS 69 Query: 109 CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V+ + ++ ME ++ + I+ + D I+ ++H Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPT---LSEYIESHGPLSVDTAINFTNQILDGIKH 126 Query: 169 LHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKPYMAPERIN 226 H + ++HRD+KP N+LI++ +K+ DFGI+ L ++ G Y +PE+ Sbjct: 127 AHD-MRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAK 185 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSP--QLPADKFS 284 E + +DI+S+GI + E+ + P++ +K + + Sbjct: 186 GEATDEC----TDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIP 241 Query: 285 AEFVDFTSQCLKKNSKERP-TYPELMQHPFFTLHESKG-TDVASFVKL 330 + + +K+ R T E+ LHE++ DV K+ Sbjct: 242 QSLSNVILRATEKDKANRYKTIQEMKDDLSSVLHENRANEDVYELDKM 289 >5AR8-A nrPDB Length = 326 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 105/273 (38%), Gaps = 17/273 (6%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR--IRATVNSQEQKRLLMDLDISMR 105 + L + L RGA G V RH +AVK I + E+K +L + +I + Sbjct: 29 IPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHK 88 Query: 106 TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 + + G + I E M + + + +I I Sbjct: 89 A-RFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALG 147 Query: 166 LEHLHSK-LSVIHRDVKPSNVLINALGQVKMCDFGISGYLV------DSVAKTIDAGCKP 218 + +LH+ ++H D+K N+L++ VK+ DFG+S + + S + G Sbjct: 148 VNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTII 207 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 YM PE P + S+K DI+S + E+ + P++ P Q + V + P + Sbjct: 208 YMPPENYEPGQKSRA-SIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVI 266 Query: 279 PADKFS------AEFVDFTSQCLKKNSKERPTY 305 + A + +N ERP++ Sbjct: 267 NEESLPYDIPHRARMISLIESGWAQNPDERPSF 299 >2WTK-B nrPDB Length = 373 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 125/326 (38%), Gaps = 61/326 (18%) Query: 53 LEPIMELGRGAYG---VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 E + +G+G + V R+ P+G+ + V+RI S E L + + Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNH 69 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P V + + ++W+ M K + E + I ++KAL+++ Sbjct: 70 PNIVPYRATFIADNELWVVTSFMAYGSAKDL-ICTHFMDGMNELAIAYILQGVLKALDYI 128 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKM---------CDFGISGYLVDSVAKTIDAGCKPYM 220 H + +HR VK S++LI+ G+V + G +V K P++ Sbjct: 129 H-HMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPK-YSVKVLPWL 186 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPY---------------------DS 259 +PE + L +GY KSDI+S+GIT ELA P+ D+ Sbjct: 187 SPEVLQQNL--QGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 260 WGTPFQQLKQV---------------------VEEPSPQLPADK-FSAEFVDFTSQCLKK 297 P ++L SP P + FS F F QCL++ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 298 NSKERPTYPELMQHPFFTLHESKGTD 323 N RP+ L+ H FF + + ++ Sbjct: 305 NPDARPSASTLLNHSFFKQIKRRASE 330 >4IDT-A nrPDB Length = 356 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 65/257 (25%), Positives = 108/257 (42%), Gaps = 22/257 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 LGRG++G V +M +G AVK++R V + ++ + P V YGA Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEV-------FRAEELMACAGLTSPRIVPLYGA 134 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 + V I MEL++ Q++ + +PED ++ LE+LHS+ ++H Sbjct: 135 VREGPWVNIFMELLEGG---SLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSR-RILHG 190 Query: 179 DVKPSNVLINALG-QVKMCDFGISGYLVDS------VAKTIDAGCKPYMAPERINPELNQ 231 DVK NVL+++ G +CDFG + L + G + +MAPE + Sbjct: 191 DVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVV----LG 246 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 + K D+WS M+ + P+ + LK E P + + Sbjct: 247 RSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAI 306 Query: 292 SQCLKKNSKERPTYPEL 308 + L+K R + EL Sbjct: 307 QEGLRKEPIHRVSAAEL 323 >6J5U-C nrPDB Length = 426 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 116/287 (40%), Gaps = 35/287 (12%) Query: 51 DDLEPIMELGRGAYGVVEK---------MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 + LG G +G V K SG ++AVK+++ Q K L +++ Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGF-QGHKEWLTEVN 142 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 + + P V G + + E M + + Q + I K+AV Sbjct: 143 Y-LGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHL-FRRGAQPLTWAIRMKVAVG 200 Query: 162 IVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISG---YLVDSVAKTIDAGCK 217 K L LH K VI+RD K +N+L++A K+ DFG++ ++ T G Sbjct: 201 AAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTH 260 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD-----------SWGTPF-- 264 Y APE + + KSD++S G+ ++EL R D W TP+ Sbjct: 261 GYAAPEYVAT----GRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLG 316 Query: 265 --QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 ++L ++++ K + + QCL ++K RP E++ Sbjct: 317 DKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >6CTH-A nrPDB Length = 309 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 113/279 (40%), Gaps = 27/279 (9%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 + +LG G +G V + S +AVK++ + + Q K ++ I R + Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKV-SRASKQGIKEYASEVKIISR-LRHK 72 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 V G G++ + E M + + ++ +I + AL +LH Sbjct: 73 NLVKLIGWCHERGELMLVYEFMANGSLD--SHIFKGKSLLTWEVRYRIVKDLASALLYLH 130 Query: 171 SK--LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD--SVAKTIDAGCKPYMAPERIN 226 + V+HRD+K SN+++++ K+ DFG++ + + KT+ AG YMAPE ++ Sbjct: 131 EEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLS 190 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRF---------------PYDSWGTPFQQLKQVV 271 S +SD++S G+ +E+A R P+ +++ + Sbjct: 191 ----SGKASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIA 246 Query: 272 EEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + K V C + RP+ +++Q Sbjct: 247 DRKLGMAFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQ 285 >5C26-A nrPDB Length = 299 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 59/257 (22%), Positives = 109/257 (42%), Gaps = 18/257 (7%) Query: 57 MELGRGAYGVVEKMRH--VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 ELG G +G V+K + + +AVK ++ N K L+ M+ +D P+ V Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 G E + + ME+ + + + + + + + + ++ + +++L + + Sbjct: 93 MIGICEAESWM-LVMEMAELG---PLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESN 147 Query: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKP---YMAPERINPELN 230 +HRD+ NVL+ K+ DFG+S L D K + APE I N Sbjct: 148 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI----N 203 Query: 231 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 +S KSD+WS G+ M E + + PY G ++ ++E+ E D Sbjct: 204 YYKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPREMYD 261 Query: 290 FTSQCLKKNSKERPTYP 306 + C + + RP + Sbjct: 262 LMNLCWTYDVENRPGFA 278 >5WNO-A nrPDB Length = 330 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 107/272 (39%), Gaps = 23/272 (8%) Query: 48 VKADDLE--PIMELGRGAYGVVEKM-----RHVPSGQIMAVKRIRATVNSQEQKRLLMDL 100 + + +L+ +LG GA+G V R +A+K + + ++ +++ Sbjct: 17 IPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDE---MLEE 73 Query: 101 DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 +M + + G + + I + + ++ + E +L Sbjct: 74 ATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVL--YCY 131 Query: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-VAKTIDAG--CK 217 I +++L K V+HRD+ NVL+ V++ DFG+S L + TI +G Sbjct: 132 QIASGMQYL-EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAI 190 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSP 276 ++A E + Y+ SD+W+ G+T E+ + PY T + +++ + Sbjct: 191 KWLAIEIFSKHC----YTHASDVWAFGVTCWEIITFGQSPYQGMSTDS--IHNFLKDGNR 244 Query: 277 QLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 S + +C + K RP + L Sbjct: 245 LSQPPNCSQDLYQELLRCWMADPKSRPGFEIL 276 >2PMN-X nrPDB Length = 348 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 76/320 (23%), Positives = 137/320 (42%), Gaps = 48/320 (15%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK---------------- 94 +D I L +G + + + A+K+ ++ +++ Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQ---VIDKGQT-- 149 +L I + + +T G + +V+I E M+ + + V+DK T Sbjct: 89 DFKNELQIIT-DIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 IP ++ I S++ + ++H++ ++ HRDVKPSN+L++ G+VK+ DFG S Y+VD Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKI 207 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ 269 K G +M PE + E + G K DIWSLGI + + P+ S +L Sbjct: 208 KGSR-GTYEFMPPEFFSNESSYNG--AKVDIWSLGICLYVMFYNVVPF-SLKISLVELFN 263 Query: 270 VVEEPSPQLPADK------------------FSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + + + P D+ S E +DF L+KN ER T + ++H Sbjct: 264 NIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKH 323 Query: 312 PFFTLHESKGTDVASFVKLI 331 + ++ D+ F K + Sbjct: 324 EWLA--DTNIEDLREFSKEL 341 >4Y83-A nrPDB Length = 332 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 65/257 (25%), Positives = 107/257 (41%), Gaps = 21/257 (8%) Query: 61 RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 RGA+G V + + + + MA K I + YGA+ Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQA-------CFRHENIAELYGAVL 135 Query: 121 REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV 180 V + M+ + ++ + E + + ++K L+ LHSK VIH D+ Sbjct: 136 WGETVHL---FMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSK-KVIHHDI 191 Query: 181 KPSNVLINALGQVKMCDFGISGYLVDSVAKTID-AGCKPYMAPERINPELNQKGYSVKSD 239 KPSN++ + V + DFG+S + + V D G + YM+PE I +G+S K+D Sbjct: 192 KPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC----RGHSTKAD 246 Query: 240 IWSLGITMIELAILRFP----YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 I+SLG T+I + P Y P + P + AD S + L Sbjct: 247 IYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASL 306 Query: 296 KKNSKERPTYPELMQHP 312 ++N RP +L++H Sbjct: 307 ERNPNHRPRAADLLKHE 323 >3ZZW-A nrPDB Length = 289 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 51/284 (17%), Positives = 99/284 (34%), Gaps = 30/284 (10%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHV-----PSGQIMAVKRIRATVNSQEQKRLLMDLD 101 E+ + + ELG +G V K Q +A+K ++ ++ + Sbjct: 5 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 64 Query: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFY------------KQVIDKGQ 148 + R + P V G + ++ + + L +F Sbjct: 65 LRAR-LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 123 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + + I +E+L S V+H+D+ NVL+ VK+ D G+ + + Sbjct: 124 ALEPPDFVHLVAQIAAGMEYL-SSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD 182 Query: 209 AKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELA-ILRFPYDSWGTPF 264 + +MAPE I +S+ SDIWS G+ + E+ PY + Sbjct: 183 YYKLLGNSLLPIRWMAPEAI----MYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSN-- 236 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 Q + +++ D A +C + RP + ++ Sbjct: 237 QDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >3Q4U-A nrPDB Length = 301 Score = 177 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 117/299 (39%), Gaps = 48/299 (16%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR-TVD 108 A D+ + +G+G YG V + G+ +AVK +S+++K + ++ + Sbjct: 7 ARDITLLECVGKGRYGEVWRGSWQ--GENVAVKI----FSSRDEKSWFRETELYNTVMLR 60 Query: 109 CPFTVTFYGALFREGD----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + F + +W+ + Y Q+ T+ +I +SI Sbjct: 61 HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT----TLDTVSCLRIVLSIAS 116 Query: 165 ALEHLH-------SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-----TI 212 L HLH K ++ HRD+K N+L+ GQ + D G++ S + Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 213 DAGCKPYMAPERINPELNQKGYS--VKSDIWSLGITMIELAIL----------RFPYDS- 259 G K YMAPE ++ + + + DIW+ G+ + E+A + P+ Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDV 236 Query: 260 --WGTPFQQLKQV--VEEPSPQLPADKFS----AEFVDFTSQCLKKNSKERPTYPELMQ 310 F+ +++V V++ P +P FS +C +N R T + + Sbjct: 237 VPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >4G3E-A nrPDB Length = 352 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 66/259 (25%), Positives = 112/259 (43%), Gaps = 22/259 (8%) Query: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 118 +GRG++G V +M+ +G AVK++R V ++ ++ + P V YGA Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEV-------FRVEELVACAGLSSPRIVPLYGA 134 Query: 119 LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 + V I MEL++ Q+I + +PED ++ LE+LH++ ++H Sbjct: 135 VREGPWVNIFMELLEGG---SLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTR-RILHG 190 Query: 179 DVKPSNVLINALG-QVKMCDFGISGYLVDS------VAKTIDAGCKPYMAPERINPELNQ 231 DVK NVL+++ G + +CDFG + L + G + +MAPE + Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVV----MG 246 Query: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 K K DIWS M+ + P+ + LK E P + + Sbjct: 247 KPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAI 306 Query: 292 SQCLKKNSKERPTYPELMQ 310 + L+K R + EL + Sbjct: 307 QEGLRKEPVHRASAMELRR 325 >6HV0-A nrPDB Length = 416 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 22/285 (7%) Query: 53 LEPIMELGRGAYGV-VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 P LG GA G V + + + +AVKRI S ++ + + + P Sbjct: 10 FCPKDVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFS----FADREVQLLRESDEHPN 63 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + ++ +I +EL +L ++ +Q + + L HLHS Sbjct: 64 VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP---ITLLQQTTSGLAHLHS 120 Query: 172 KLSVIHRDVKPSNVLI---NALGQVK--MCDFGISGYLVDSVA----KTIDAGCKPYMAP 222 L+++HRD+KP N+LI NA G++K + DFG+ L ++ G + ++AP Sbjct: 121 -LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP 179 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 E ++ + + + DI+S G + P+ + P Sbjct: 180 EMLSEDCKENP-TYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEK 238 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 + + + + ++RP+ +++HPFF E + Sbjct: 239 HEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQD 283 >2WO6-A nrPDB Length = 382 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 57/235 (24%), Positives = 102/235 (43%), Gaps = 15/235 (6%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 +N E D E +G+G++G V K + +A+K I+ Q ++ + L Sbjct: 47 KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLEL 106 Query: 104 MRTVDCP---FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 M D + V + + E++ +L + +G ++ + K A Sbjct: 107 MNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLN--LTRKFAQ 164 Query: 161 SIVKALEHLHS-KLSVIHRDVKPSNVLINALGQ--VKMCDFGISGYLVDSVAKTIDAGCK 217 + AL L + +LS+IH D+KP N+L+ + +K+ DFG S L + + I + Sbjct: 165 QMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQ--SR 222 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 Y +PE L Y + D+WSLG ++E+ P S Q+ ++VE Sbjct: 223 FYRSPEV----LLGMPYDLAIDMWSLGCILVEMHTGE-PLFSGANEVDQMNKIVE 272 Score = 37.6 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 13/30 (43%) Query: 286 EFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 +F D + L + K R +QH FF Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFK 377 >3RAW-A nrPDB Length = 381 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 65/329 (19%), Positives = 118/329 (35%), Gaps = 73/329 (22%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQ-IMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + E + LG G +G V + G+ +A+K IR +E RL +++ ++ D Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDK 110 Query: 110 PF---TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 V G + I EL+ + +F K+ + Q P + +A + AL Sbjct: 111 ENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE--NNFQPYPLPHVRHMAYQLCHAL 168 Query: 167 EHLHSKLSVIHRDVKPSNVL-INALGQ------------------VKMCDFGISGYLVDS 207 LH + H D+KP N+L +N+ + +++ DFG + + D Sbjct: 169 RFLHEN-QLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF--DH 225 Query: 208 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ-Q 266 T + Y PE I + G++ D+WS+G + E + + Sbjct: 226 EHHTTIVATRHYRPPEVI----LELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLV 281 Query: 267 LKQVVEEPSPQ----------------LPADKFSAE------------------------ 286 + + + P P L D+ S++ Sbjct: 282 MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQ 341 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 D + L+ + +R T E + HPFF Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFFA 370 >3MDY-A nrPDB Length = 337 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 118/294 (40%), Gaps = 48/294 (16%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 A ++ + ++G+G YG V + G+ +AVK T + + + + MR Sbjct: 36 AKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLMR---H 90 Query: 110 PFTVTFYGALFREG----DVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 + F A + +++ + + SL + K T+ + K+A S V Sbjct: 91 ENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYL-----KSTTLDAKSMLKLAYSSVS 145 Query: 165 ALEHLHS-------KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV-----AKTI 212 L HLH+ K ++ HRD+K N+L+ G + D G++ + Sbjct: 146 GLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNT 205 Query: 213 DAGCKPYMAPERINPELNQKGY--SVKSDIWSLGITMIELAIL----------RFPYDSW 260 G K YM PE ++ LN+ + + +D++S G+ + E+A + PY Sbjct: 206 RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDL 265 Query: 261 ---GTPFQQLKQV--VEEPSPQLPADKFSAEFVD----FTSQCLKKNSKERPTY 305 ++ ++++ +++ P P S E + ++C N R T Sbjct: 266 VPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >5VC6-A nrPDB Length = 289 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 116/284 (40%), Gaps = 37/284 (13%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV-NSQEQKRLLMDLDISMRTVDC 109 + + ++G G +G V K G I A+KR + + S +++ L ++ Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQH 70 Query: 110 PFTVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V ++ A + + I E + L + E L + + + + L + Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 169 LHSKLSVIHRDVKPSNVLINALGQV-------------------KMCDFGISGYLVDSVA 209 +HS +S++H D+KPSN+ I+ K+ D G ++ + Sbjct: 131 IHS-MSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG---HVTRISS 186 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSV--KSDIWSLGITMIELAILRFPYDSWGTPFQQL 267 ++ G ++A E + Q+ Y+ K+DI++L +T++ A P G + ++ Sbjct: 187 PQVEEGDSRFLANEVL-----QENYTHLPKADIFALALTVV-CAAGAEPLPRNGDQWHEI 240 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 +Q PQ+ S EF + + + + RP+ L++H Sbjct: 241 RQGRLPRIPQV----LSQEFTELLKVMIHPDPERRPSAMALVKH 280 >4PL5-B nrPDB Length = 435 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 110/285 (38%), Gaps = 22/285 (7%) Query: 53 LEPIMELGRGAYGV-VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 P LG GA G V K + + +AVKRI S ++ + + + P Sbjct: 29 FCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRILPECFS----FADREVQLLRESDEHPN 82 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + ++ +I +EL +L ++ +Q + + L HLHS Sbjct: 83 VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP---ITLLHQTTSGLAHLHS 139 Query: 172 KLSVIHRDVKPSNVLI---NALGQVK--MCDFGISGYLVDSVA----KTIDAGCKPYMAP 222 L+++HRD+KP N+L+ NA G++K + DFG+ L ++ G + ++AP Sbjct: 140 -LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP 198 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 E ++ + + DI+S G + P+ + Sbjct: 199 EMLSEDCKDNP-TYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHSDK 257 Query: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 + + + + ++RP+ +++HPFF E + Sbjct: 258 HEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQD 302 >5UNP-A nrPDB Length = 369 Score = 173 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 120/330 (36%), Gaps = 73/330 (22%) Query: 51 DDLEPIMELGRGAYGVVEKMR-HVPSGQIMAVKRIRATVNSQEQKRLLMDL--DISMRTV 107 + E + LG G +G V + H G +A+K I+ +E RL +++ I+ + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDP 93 Query: 108 DCPFT-VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 D V + G + I EL+ S F K + P + +A + +A+ Sbjct: 94 DNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKD--NNYLPYPIHQVRHMAFQLCQAV 151 Query: 167 EHLHSKLSVIHRDVKPSNVL-INALGQ------------------VKMCDFGISGYLVDS 207 + LH + H D+KP N+L +N+ + V++ DFG + + D Sbjct: 152 KFLHDN-KLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF--DH 208 Query: 208 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ-Q 266 + + Y APE I + G+S D+WS+G + E + + + Sbjct: 209 EHHSTIVSTRHYRAPEVI----LELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 264 Query: 267 LKQVVEEPSP----------------QLPADKFSAE------------------------ 286 + + + P P +L D+ ++ Sbjct: 265 MMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQ 324 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFTL 316 D L+ +R T E +QHPFF Sbjct: 325 LFDLIESMLEYEPAKRLTLGEALQHPFFAR 354 >4MD7-E nrPDB Length = 391 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 126/303 (41%), Gaps = 54/303 (17%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC- 109 DD + + +LGRG Y V + ++ + + + + +K+ + + + Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRGG 91 Query: 110 PFTVTFYGALFRE--GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 P +T + + E ++ + +KQ+ QT+ + + I+KAL+ Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLY---QTLTDYDIRFYMYEILKALD 145 Query: 168 HLHSKLSVIHRDVKPSNVLINALGQ-VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 + HS + ++HRDVKP NV+I+ + +++ D+G++ + + + + PE + Sbjct: 146 YCHS-MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELL- 203 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV------------VEEP 274 ++ + Y D+WSLG + + + P+ + QL ++ +++ Sbjct: 204 --VDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 Query: 275 SPQLPA-----------------------DKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 + +L S E +DF + L+ + + R T E M+H Sbjct: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 Query: 312 PFF 314 P+F Sbjct: 322 PYF 324 >2PVN-A nrPDB Length = 352 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 122/303 (40%), Gaps = 52/303 (17%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 DD E + ++GRG Y V + +V + + K I + ++K++ ++ I P Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCGGP 107 Query: 111 FTVTFYGAL--FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 V + + E ++ + K T+ + + ++KAL++ Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL------YPTLTDYDIRYYIYELLKALDY 161 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ-VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227 HS+ ++HRDVKP NV+I+ + +++ D+G++ + + + + PE + Sbjct: 162 CHSQ-GIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELL-- 218 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--------------- 272 ++ + Y D+WSLG + + P+ QL ++ + Sbjct: 219 -VDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYR 277 Query: 273 -EPSPQLPA-------------------DKFSAEFVDFTSQCLKKNSKERPTYPELMQHP 312 E PQL A S E +DF + L+ + +ER T E M HP Sbjct: 278 IELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHP 337 Query: 313 FFT 315 +F Sbjct: 338 YFQ 340 >6HMD-A nrPDB Length = 365 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 121/303 (39%), Gaps = 54/303 (17%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 DD + + +LGRG Y V + ++ + + R+ + +K+ + + + Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 107 Query: 111 -FTVTFYGALFRE--GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 + + + E ++ + K Q+ + + + ++KAL+ Sbjct: 108 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI------LTDFDIRFYMYELLKALD 161 Query: 168 HLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERIN 226 + HSK ++HRDVKP NV+I+ ++++ D+G++ + + + + + PE + Sbjct: 162 YCHSK-GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL- 219 Query: 227 PELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV------------VEEP 274 ++ + Y D+WSLG + + R P+ + QL ++ +++ Sbjct: 220 --VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 277 Query: 275 SPQLPADK-----------------------FSAEFVDFTSQCLKKNSKERPTYPELMQH 311 L S E +D + L+ + ++R T E M+H Sbjct: 278 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 337 Query: 312 PFF 314 P+F Sbjct: 338 PYF 340 >6EII-A nrPDB Length = 352 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 60/334 (17%), Positives = 129/334 (38%), Gaps = 60/334 (17%) Query: 20 FEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM 79 + T + GNQ DD + + +LGRG Y V + ++ + + Sbjct: 35 YTDVNTHRPSEYWDYESHVVEWGNQ------DDYQLVRKLGRGKYSEVFEAINITNNEK- 87 Query: 80 AVKRIRATVNSQEQKRLLMDLDISMRTVDC-PFTVTFYGALFRE--GDVWICMELMDTSL 136 + + +K+ + + + P +T + + E ++ + Sbjct: 88 ----VVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD 143 Query: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-VKM 195 K QT+ + + I+KAL++ HS + ++HRDVKP NV+I+ + +++ Sbjct: 144 FKQL------YQTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKLRL 196 Query: 196 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 D+G++ + + + + PE + ++ + Y D+WSLG + + + Sbjct: 197 IDWGLAEFYHPGQEYNVRVASRYFKGPELL---VDYQMYDYSLDMWSLGCMLASMIFRKE 253 Query: 256 PYDSWGTPFQQLKQV------------VEEPSPQLPA----------------------- 280 P+ + QL ++ +++ + +L Sbjct: 254 PFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ 313 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 S E +DF + L+ + + R T E M+HP+F Sbjct: 314 HLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >3MY0-A nrPDB Length = 305 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 120/295 (40%), Gaps = 50/295 (16%) Query: 55 PIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR-TVDCPFTV 113 + +G+G YG V + G+ +AVK +S++++ + +I + + Sbjct: 12 LVECVGKGRYGEVWRGLW--HGESVAVKI----FSSRDEQSWFRETEIYNTVLLRHDNIL 65 Query: 114 TFYGALFREGD----VWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 F + + +W+ + SL F ++ QT+ + ++AVS L H Sbjct: 66 GFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR-----QTLEPHLALRLAVSAACGLAH 120 Query: 169 LH-------SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-----TIDAGC 216 LH K ++ HRD K NVL+ + Q + D G++ G Sbjct: 121 LHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGT 180 Query: 217 KPYMAPERINPELNQKGY-SVK-SDIWSLGITMIELAIL----------RFPYDS---WG 261 K YMAPE ++ ++ + S K +DIW+ G+ + E+A R P+ Sbjct: 181 KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND 240 Query: 262 TPFQQLKQV--VEEPSPQLP----ADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 F+ +K+V V++ +P +P AD + +C N R T + + Sbjct: 241 PSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 295 >4JLC-A nrPDB Length = 657 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 48/231 (20%), Positives = 90/231 (38%), Gaps = 15/231 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+GA V + RH +G + AVK + + + ++ ++ ++ V + Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEV-LKKLNHKNIVKLFA 73 Query: 118 ALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ME + +PE + +V + HL + Sbjct: 74 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-GI 132 Query: 176 IHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL-- 229 +HRD+KP N++ I GQ K+ DFG + L D G + Y+ P+ + Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQVVEEPS 275 +QK Y D+WS+G+T A P+ + P + + +++ Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 243 >3QD2-B nrPDB Length = 332 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 122/334 (36%), Gaps = 80/334 (23%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D EPI +GRG +GVV + ++ A+KRIR +++++ ++ ++ ++ P Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVK-ALAKLEHP 64 Query: 111 FT---------------------------------------------VTFYGALFREG-- 123 + + Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 124 ----------DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL 173 ++I M+L K + + + I + I +A+E LHSK Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK- 183 Query: 174 SVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-------------TIDAGCKPYM 220 ++HRD+KPSN+ VK+ DFG+ + + T G K YM Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 +PE+I + YS K DI+SLG+ + EL + + + + + V P L Sbjct: 244 SPEQI----HGNNYSHKVDIFSLGLILFELL---YSFSTQMERVRIITDVRNLKFPLLFT 296 Query: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 K+ E L + ERP +++++ F Sbjct: 297 QKYPQE-HMMVQDMLSPSPTERPEATDIIENAIF 329 >4EUU-A nrPDB Length = 319 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 90/231 (38%), Gaps = 15/231 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+GA V + RH +G + A+K + + + ++ ++ ++ V + Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-LKKLNHKNIVKLFA 74 Query: 118 ALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ME + +PE + +V + HL + Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-GI 133 Query: 176 IHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL-- 229 +HR++KP N++ I GQ K+ DFG + L D G + Y+ P+ + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQVVEEPS 275 +QK Y D+WS+G+T A P+ + P + + +++ Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >5TE0-A nrPDB Length = 347 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 111/284 (39%), Gaps = 36/284 (12%) Query: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 F + + L G + +V +R +G A+KR+ N + + ++ I Sbjct: 14 FGIGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVN-NEHDLQVCKREIQIMRD 71 Query: 106 TVDCPFTVTFYGALFRE---GDVW---ICMELMDTS-LDKFYKQVIDKGQTIPEDILGKI 158 V + + GDVW I M+ + Q + G E+ + +I Sbjct: 72 LSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG--FTENEVLQI 129 Query: 159 AVSIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISGY------------LV 205 +A+ LH K +IHRD+K N+L++ G +CDFG + + Sbjct: 130 FCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVE 189 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 D + K Y APE +N + K + K+DIW+LG + +L P+ Sbjct: 190 DEIKKYT---TLSYRAPEMVNL-YSGKIITTKADIWALGCLLYKLCYFTLPFGESQV--- 242 Query: 266 QLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + + +P + ++S + L+ + +RP ++ Sbjct: 243 ----AICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >4EUT-A nrPDB Length = 396 Score = 167 bits (423), Expect = 7e-42, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 90/231 (38%), Gaps = 15/231 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+GA V + RH +G + A+K + + + ++ ++ ++ V + Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-LKKLNHKNIVKLFA 74 Query: 118 ALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ME + +PE + +V + HL + Sbjct: 75 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-GI 133 Query: 176 IHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL-- 229 +HR++KP N++ I GQ K+ DFG + L D G + Y+ P+ + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQVVEEPS 275 +QK Y D+WS+G+T A P+ + P + + +++ Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 244 >3SOC-A nrPDB Length = 322 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 124/309 (40%), Gaps = 50/309 (16%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKR 95 + + +G +N ++ L+ + RG +G V K + + + +AVK Q+++ Sbjct: 9 SSGVDLGTENLYFQSMPLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPI----QDKQS 62 Query: 96 LLMDLDI-SMRTVDCPFTVTFYGALFREG----DVWICMELMD-TSLDKFYKQVIDKGQT 149 + ++ S+ + + F GA R D+W+ + SL F K Sbjct: 63 WQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-----KANV 117 Query: 150 IPEDILGKIAVSIVKALEHLHS---------KLSVIHRDVKPSNVLINALGQVKMCDFGI 200 + + L IA ++ + L +LH K ++ HRD+K NVL+ + DFG+ Sbjct: 118 VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGL 177 Query: 201 SGYLVDSVA---KTIDAGCKPYMAPERINPELNQKGYSV-KSDIWSLGITMIELAILRF- 255 + + G + YMAPE + +N + + + D++++G+ + ELA Sbjct: 178 ALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTA 237 Query: 256 ---PYDSWGTPFQQLKQ-----------VVEEPSPQLPADKFSAEF-----VDFTSQCLK 296 P D + PF++ VV + + D + + +C Sbjct: 238 ADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWD 297 Query: 297 KNSKERPTY 305 +++ R + Sbjct: 298 HDAEARLSA 306 >3LLT-A nrPDB Length = 360 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 71/361 (19%), Positives = 126/361 (34%), Gaps = 95/361 (26%) Query: 40 SIGNQNFEVKADD----------------LEPIMELGRGAYGVVEKMRHVPSGQIMAVKR 83 S G +N + DD I ++G G +G V +H+ + + AVK Sbjct: 8 SSGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKV 67 Query: 84 IRATVNSQEQKRLLMDL--DISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYK 141 +R ++ D+ I ++ V ++G + + E + SL + Sbjct: 68 VRNIKKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIIT 127 Query: 142 QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ--------- 192 + G I + + + I+KAL +L K+S+ H D+KP N+L++ Sbjct: 128 RNNYNGFHI--EDIKLYCIEILKALNYL-RKMSLTHTDLKPENILLDDPYFEKSLITVRR 184 Query: 193 ----------------VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 +K+ DFG + + D I+ + Y APE I G+ V Sbjct: 185 VTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSIIN--TRQYRAPEVI----LNLGWDV 238 Query: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQ-QLKQVVEEPSPQ------------------ 277 SD+WS G + EL + + + + + +P P+ Sbjct: 239 SSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKD 298 Query: 278 -----LPADKFS-------------------AEFVDFTSQCLKKNSKERPTYPELMQHPF 313 P + S F DF L+ + RP+ EL++H F Sbjct: 299 ELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKF 358 Query: 314 F 314 Sbjct: 359 L 359 >2QKW-B nrPDB Length = 321 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 117/283 (41%), Gaps = 26/283 (9%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 104 + E ++ + +G G +G V K G +A+K R T S + ++ Sbjct: 33 DLEEATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALK--RRTPESSQGIEEFETEIETL 89 Query: 105 RTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIV 163 P V+ G ++ + + M+ +L + ++ + +I + Sbjct: 90 SFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAA 149 Query: 164 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISG---YLVDSVAKTIDAGCKPYM 220 + L +LH++ +IHRDVK N+L++ K+ DFGIS L + T+ G Y+ Sbjct: 150 RGLHYLHTRA-IIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYI 208 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILR------FP--------YDSWGTPFQQ 266 PE + + KSD++S G+ + E+ R P + Q Sbjct: 209 DPEYFI----KGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQ 264 Query: 267 LKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 L+Q+V+ + +F D +CL +S++RP+ +++ Sbjct: 265 LEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >6O8B-A nrPDB Length = 665 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 90/231 (38%), Gaps = 15/231 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+GA V + RH +G + A+K + + + ++ ++ ++ V + Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-LKKLNHKNIVKLFA 80 Query: 118 ALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ME + +PE + +V + HL + Sbjct: 81 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-GI 139 Query: 176 IHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL-- 229 +HR++KP N++ I GQ K+ DFG + L D G + Y+ P+ + Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQVVEEPS 275 +QK Y D+WS+G+T A P+ + P + + +++ Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 250 >1PY5-A nrPDB Length = 326 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 122/297 (41%), Gaps = 50/297 (16%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SMRTVDCPF 111 + +G+G +G V + + G+ +AVK +S+E++ + +I + Sbjct: 31 IVLQESIGKGRFGEVWRGKWR--GEEVAVKI----FSSREERSWFREAEIYQTVMLRHEN 84 Query: 112 TVTFYGALFREG----DVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + F A ++ +W+ + + SL + + T+ + + K+A+S L Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY-----TVTVEGMIKLALSTASGL 139 Query: 167 EHLH-------SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD-----SVAKTIDA 214 HLH K ++ HRD+K N+L+ G + D G++ +A Sbjct: 140 AHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRV 199 Query: 215 GCKPYMAPERINPELNQKGYS--VKSDIWSLGITMIELAIL----------RFPYDSW-- 260 G K YMAPE ++ +N K + ++DI+++G+ E+A + PY Sbjct: 200 GTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVP 259 Query: 261 -GTPFQQLKQVV--EEPSPQLPADKFSAE----FVDFTSQCLKKNSKERPTYPELMQ 310 +++++VV ++ P +P S E +C N R T + + Sbjct: 260 SDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 316 >6NT9-A nrPDB Length = 742 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 90/231 (38%), Gaps = 15/231 (6%) Query: 58 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 LG+GA V + RH +G + A+K + + + ++ ++ ++ V + Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV-LKKLNHKNIVKLFA 72 Query: 118 ALFREG--DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 + ME + +PE + +V + HL + Sbjct: 73 IEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLREN-GI 131 Query: 176 IHRDVKPSNVL--INALGQ--VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPEL-- 229 +HR++KP N++ I GQ K+ DFG + L D G + Y+ P+ + Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 230 --NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---FQQLKQVVEEPS 275 +QK Y D+WS+G+T A P+ + P + + +++ Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKP 242 >5XD6-A nrPDB Length = 305 Score = 163 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 69/244 (28%), Positives = 100/244 (40%), Gaps = 21/244 (8%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 D+ +G G+YG V SG+ A+K++ + Q + L + + R + Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKL--DSSKQPDQEFLAQVSMVSR-LRQE 77 Query: 111 FTVTFYGALFREGDVWICMELM-DTSLDKFYK-----QVIDKGQTIPEDILGKIAVSIVK 164 V G + E + SL + G + KIAV + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 165 ALEHLHSKLS--VIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK---TIDAGCKPY 219 LE+LH K + VIHRD+K SNVL+ K+ DF +S D A+ T G Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 APE S KSD++S G+ ++EL R P D QQ VV +P+L Sbjct: 198 HAPEY----AMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQ--SVVTWATPKLS 251 Query: 280 ADKF 283 DK Sbjct: 252 EDKV 255 >5IKW-A nrPDB Length = 310 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 110/290 (37%), Gaps = 33/290 (11%) Query: 38 CISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLL 97 +S+G + F V + L G + V +R G A+KR+ N + Sbjct: 1 SMSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRM-YVNNMPDLNVCK 58 Query: 98 MDLDISMRTVDCPFTVTFYGALFRE--GDVW---ICMELMDTSLDKFYKQVIDKGQT-IP 151 ++ I V + +VW I ME + Q+ K QT Sbjct: 59 REITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAG--QVVNQMNKKLQTGFT 116 Query: 152 EDILGKIAVSIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISG-------- 202 E + +I +A+ LH K +IHRD+K N+L+N G +CDFG + Sbjct: 117 EPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQK 176 Query: 203 ---YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 +V+ K Y APE IN K + K+DIW+LG + +L P+ Sbjct: 177 DGVNVVEEEIKKYT--TLSYRAPEMINL-YGGKPITTKADIWALGCLLYKLCFFTLPFGE 233 Query: 260 WGTPFQQLKQVVEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPEL 308 + + + +P + ++S L+ + + RP ++ Sbjct: 234 SQV-------AICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >5XVU-A nrPDB Length = 332 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 53/305 (17%), Positives = 111/305 (36%), Gaps = 54/305 (17%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD 108 K + E + ++GRG Y V + A V +K+ + ++ ++ Sbjct: 29 KPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKKIKREIKILQNLN 83 Query: 109 C-PFTVTFYGALFRE--GDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 P + + + E ++ K + + I+KA Sbjct: 84 GGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL------YPKFTDKDIRYYIYQILKA 137 Query: 166 LEHLHSKLSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 L++ HS+ ++HRDVKP N++I+ Q+++ +G++ + + + Y PE Sbjct: 138 LDYCHSQ-GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPEL 196 Query: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE------------ 272 + ++ + Y DIWSLG + + + P+ + QL ++ + Sbjct: 197 L---IDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLK 253 Query: 273 ------EPSP-----QLPADKFS------------AEFVDFTSQCLKKNSKERPTYPELM 309 +P + +S E +D + L + +R E M Sbjct: 254 KYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAM 313 Query: 310 QHPFF 314 +HP+F Sbjct: 314 EHPYF 318 >4OW8-A nrPDB Length = 283 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 104/260 (40%), Gaps = 20/260 (7%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVDC 109 + G G V + G+ +AVK +++ +S + +R + + ++ Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEAR-TTAMLNH 70 Query: 110 PFTVTFYGALFREGD-----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 P + + + + ++ MEL++ + V+ + + + + Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNG---EPLNSVLKRTGRLSLRHALDMLEQTGR 127 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKPYMAP 222 AL+ H+ ++HRDVKP N+LI GQVK+ DFGI+ + + G Y+AP Sbjct: 128 ALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 186 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E + S SD++SLG+ E + P+ G +K + E P P P Sbjct: 187 E----QALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLP 242 Query: 283 FSAEFVDFTSQCLKKNSKER 302 + L KN R Sbjct: 243 --PNVRELIEITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 104/260 (40%), Gaps = 20/260 (7%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVDC 109 + G G V + G+ +AVK +++ +S + +R + + ++ Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEAR-TTAMLNH 71 Query: 110 PFTVTFYGALFREGD-----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 P + + + + ++ MEL++ + V+ + + + + Sbjct: 72 PGIASVHDYGESQMNGEGRTAYLVMELVNG---EPLNSVLKRTGRLSLRHALDMLEQTGR 128 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKPYMAP 222 AL+ H+ ++HRDVKP N+LI GQVK+ DFGI+ + + G Y+AP Sbjct: 129 ALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 187 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E + S SD++SLG+ E + P+ G +K + E P P P Sbjct: 188 E----QALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLP 243 Query: 283 FSAEFVDFTSQCLKKNSKER 302 + L KN R Sbjct: 244 --PNVRELIEITLVKNPAMR 261 >6B2Q-A nrPDB Length = 317 Score = 161 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 57/260 (21%), Positives = 104/260 (40%), Gaps = 20/260 (7%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVDC 109 + G G V + G+ +AVK +++ +S + +R + + ++ Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEAR-TTAMLNH 91 Query: 110 PFTVTFYGALFREGD-----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 P + + + + ++ MEL++ + V+ + + + + Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNG---EPLNSVLKRTGRLSLRHALDMLEQTGR 148 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKPYMAP 222 AL+ H+ ++HRDVKP N+LI GQVK+ DFGI+ + + G Y+AP Sbjct: 149 ALQIAHA-AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAP 207 Query: 223 ERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADK 282 E + S SD++SLG+ E + P+ G +K + E P P P Sbjct: 208 E----QALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLP 263 Query: 283 FSAEFVDFTSQCLKKNSKER 302 + L KN R Sbjct: 264 --PNVRELIEITLVKNPAMR 281 >2JD5-A nrPDB Length = 373 Score = 161 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 61/329 (18%), Positives = 119/329 (36%), Gaps = 75/329 (22%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 + +LG G + V + + + +A+K +R E ++ + R D Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAE--DEIKLLQRVNDADN 77 Query: 112 ----------TVTFYGALFREG----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 + +G V + E++ +L K+ +G IP + + Sbjct: 78 TKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRG--IPLIYVKQ 135 Query: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLI------NALGQVKMCDFGISGYLVDSVAKT 211 I+ ++ L+++H + +IH D+KP NVL+ L Q+K+ D G + + + + Sbjct: 136 ISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNS 195 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD-----SWGTPFQQ 266 I + Y +PE + + +DIWS + EL F ++ S+ Sbjct: 196 IQ--TREYRSPEVLLGA----PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDH 249 Query: 267 LKQVV----EEPSPQLPADKFS------------------------------------AE 286 + Q++ E PS L K++ E Sbjct: 250 IAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 287 FVDFTSQCLKKNSKERPTYPELMQHPFFT 315 DF S L+ + ++R L+ HP+ Sbjct: 310 ISDFLSPMLQLDPRKRADAGGLVNHPWLK 338 >5J0A-A nrPDB Length = 300 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 127/287 (44%), Gaps = 35/287 (12%) Query: 55 PIMELGRGAYGVVEKMRHVPSGQ---IMAVKRIRATVN----SQEQKRLLMDLDISMRTV 107 + +LG G V M+ P G AVK+I N S QKRL+ + I ++++ Sbjct: 13 FMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKI-LKSL 71 Query: 108 DCPFTVTFYGALF-REGDVWICMELM-DTSLDKFYKQVIDKGQ-TIPEDILGKIAVSIVK 164 P V + +G + + ME + SL+ ++ Q P I+ K+A+++ + Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 165 ALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSVAKTID----AGCKPY 219 L++LH + ++H D+K SNV+I +K+CD G+S L +++ T G +P+ Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP--------------YDSWGTPFQ 265 E + + K+DI++ G+T+ E+ L P +D + Sbjct: 192 KPKEAVEE---NGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDE 248 Query: 266 QLKQVVEEPSP--QLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + P D+ + ++ S C ++ K+RP+ +++ Sbjct: 249 AYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >4M66-A nrPDB Length = 325 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 106/284 (37%), Gaps = 41/284 (14%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107 V ++L+ + +G+G +GVV + H +AVK + + S E K +M + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVK--------AMVNL 68 Query: 108 DCPFTVTFYGALFREGDVW-------ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAV 160 + G E W + M+ ++ P +L ++ Sbjct: 69 RNENVLLLLGV--TEDLQWDFVSGQALVTRFMENG---SLAGLLQPEAPRPWPLLCRLLQ 123 Query: 161 SIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISGY-------LVDSVAKTI 212 +V + +LHS ++HRD+KPSN+L++ K+ DFG+S + Sbjct: 124 EVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRD 183 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 G Y+ PE + S SD++S GI + + R +++ V Sbjct: 184 SGGTLAYLDPELLFKV--NLKASKASDVYSFGILVWAVLAGRE--AELVDKTSLIRETVC 239 Query: 273 EPSPQLPADKFSA---------EFVDFTSQCLKKNSKERPTYPE 307 + + P + + + C S+ RP++ + Sbjct: 240 DRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >4TN6-A nrPDB Length = 318 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 57/276 (20%), Positives = 111/276 (40%), Gaps = 27/276 (9%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 + ++G G++G + + +G+ +A+K + Q + + M+ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGVGI 65 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 T+ + GA + MEL+ SL+ + K + +A ++ +E++H Sbjct: 66 PTIRWCGA--EGDYNVMVMELLGPSLEDLFNFCSRK---FSLKTVLLLADQMISRIEYIH 120 Query: 171 SKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVD--------SVAKTIDAGCKPY 219 SK + IHRDVKP N L+ V + DFG++ D G Y Sbjct: 121 SK-NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARY 179 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEP--- 274 + IN L + S + D+ SLG ++ + P+ T Q+ +++ E+ Sbjct: 180 AS---INTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMST 235 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 ++ + +EF + + C ++P Y L Q Sbjct: 236 PIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQ 271 >4CRL-A nrPDB Length = 406 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 67/357 (18%), Positives = 120/357 (33%), Gaps = 73/357 (20%) Query: 30 PRDLDSKACISIGNQNFEVKADDLEPIM-ELGRGAYGVVEKMRHVPSGQI--MAVKRIRA 86 D D K +S + E D E ++GRG YG V K + A+K+I Sbjct: 3 KMDYDFKVKLSSERERVE---DLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEG 59 Query: 87 TVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR--EGDVWICMELMDTSLDKFYK--- 141 T S ++ +R + P ++ + VW+ + + L K Sbjct: 60 TGISMS---ACREIA-LLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHR 115 Query: 142 --QVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN----ALGQVKM 195 + K +P ++ + I+ + +LH+ V+HRD+KP+N+L+ G+VK+ Sbjct: 116 ASKANKKPVQLPRGMVKSLLYQILDGIHYLHANW-VLHRDLKPANILVMGEGPERGRVKI 174 Query: 196 CDFGISGYLVDSVAKTID----AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELA 251 D G + + D Y APE + L + Y+ DIW++G EL Sbjct: 175 ADMGFARLFNSPLKPLADLDPVVVTFWYRAPELL---LGARHYTKAIDIWAIGCIFAELL 231 Query: 252 ILRFPYDS-----------WGTPFQQLKQ------------VVEEPSPQLPADKF----- 283 + ++ + + P F Sbjct: 232 TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTY 291 Query: 284 ----------------SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDV 324 ++ + L + +R T + MQ P+F +DV Sbjct: 292 TNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDV 348 >3SV0-A nrPDB Length = 483 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 57/280 (20%), Positives = 113/280 (40%), Gaps = 35/280 (12%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVD-- 108 + ++G G++G + ++ + + +A+K + +LL + I R + Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHPQLLYESKIY-RILQGG 62 Query: 109 --CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 P V ++G + M+L+ SL+ + K + + +A ++ + Sbjct: 63 TGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSRK---LSLKTVLMLADQMINRV 116 Query: 167 EHLHSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVDSV--------AKTIDAG 215 E +HSK S +HRD+KP N L+ QV + DFG++ D+ G Sbjct: 117 EFVHSK-SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTG 175 Query: 216 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW--GTPFQQLKQVVEE 273 Y + +N L + S + D+ SLG ++ P+ GT Q+ +++ E+ Sbjct: 176 TARYAS---VNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEK 231 Query: 274 P---SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 S + + EF + C ++P Y L + Sbjct: 232 KVATSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKR 271 >5VDK-A nrPDB Length = 297 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 53/283 (18%), Positives = 107/283 (37%), Gaps = 37/283 (13%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR-IRATVNSQEQKRLLMDLDISMRTVDC 109 + + ++G G +G V K G + A+KR ++ + L ++ Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 110 PFTVTFYGALFREGDVWICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEH 168 P V +Y + + + I E + L + G E L I + I L + Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 169 LHSKLSVIHRDVKPSNVLINALGQ-----------------------VKMCDFGISGYLV 205 +H S++H D+KPSN+ I Q K+ D G + + Sbjct: 135 IH-NSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 193 Query: 206 DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 ++ G ++A E + + K+DI++LG+T+ +A + G + Sbjct: 194 ---KPKVEEGDSRFLANEILQEDYRHLP---KADIFALGLTIA-VAAGAESLPTNGAAWH 246 Query: 266 QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +++ P +P + S F ++ ++++RP+ L Sbjct: 247 HIRK---GNFPDVPQE-LSESFSSLLKNMIQPDAEQRPSAAAL 285 >5FQD-C nrPDB Length = 341 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 115/277 (41%), Gaps = 33/277 (11%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMD---LDISMRTVDC 109 + + ++G G++G + ++ +G+ +AVK +LL + I V Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQLLYESKLYKILQGGVGI 77 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 P +YG + + M+L+ SL+ + + + +A ++ +E++ Sbjct: 78 PHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSRR---FTMKTVLMLADQMISRIEYV 131 Query: 170 HSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVDSVAK--------TIDAGCKP 218 H+K + IHRD+KP N L+ ++ + DFG++ D+ + G Sbjct: 132 HTK-NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTAR 190 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEP-- 274 Y + IN L + S + D+ SLG ++ P+ T Q+ +++ E+ Sbjct: 191 YAS---INAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMS 246 Query: 275 -SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 ++ F AEF + + C +E P Y L Q Sbjct: 247 TPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQ 283 >4MWI-A nrPDB Length = 294 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 56/306 (18%), Positives = 122/306 (39%), Gaps = 34/306 (11%) Query: 19 AFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQI 78 A P + + + + ++ + L +G Y H Sbjct: 2 AMGSKCMQEIPQEQIKEIKKEQLSGSPWILLREN--EVSTLYKGEY-------HRA---P 49 Query: 79 MAVK---RIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREG----DVWICMEL 131 +A+K +++A + ++ ++ +M+ + P + +G E I ME Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIK-TMKKFESPNILRIFGICIDETVTPPQFSIVMEY 108 Query: 132 MDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH-SKLSVIHRDVKPSNVLINAL 190 + ++++D+ + + + + + L LH S+ +H ++ SN L+ Sbjct: 109 CELGT---LRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQG 165 Query: 191 GQVKMCDFGI-----SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGI 245 QVK+ F + S L + KT Y++P+ + Q Y VKS+I+S GI Sbjct: 166 YQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQ--YDVKSEIYSFGI 223 Query: 246 TMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPT 304 + E+A P+ G ++++++V Q P + +E + +C + RP+ Sbjct: 224 VLWEIATGDIPFQ--GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPS 281 Query: 305 YPELMQ 310 E+++ Sbjct: 282 VDEILK 287 >5E8V-A nrPDB Length = 316 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 118/298 (39%), Gaps = 53/298 (17%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSG----QIMAVKRIRATVNSQEQKRLLMDLDISMR-TV 107 +E +G+G + V K + + + +AVK +E + DI + Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKI----FPYEEYASWKTEKDIFSDINL 66 Query: 108 DCPFTVTFYGALFREGDV----WICMEL-MDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 + F A R+ ++ W+ +L ++ + I + L K+ S+ Sbjct: 67 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTR-----HVISWEDLRKLGSSL 121 Query: 163 VKALEHLHS--------KLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-----VDSVA 209 + + HLHS K+ ++HRD+K SN+L+ +CDFG+S L VD +A Sbjct: 122 ARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA 181 Query: 210 KTIDAGCKPYMAPERINPELNQKGYS--VKSDIWSLGITMIELAIL----------RFPY 257 + G YMAPE + +N + ++D++S+ + + E+ P+ Sbjct: 182 NSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF 241 Query: 258 DSWGTPFQQLKQVVEE-----PSPQLPADKFSAEFVDF----TSQCLKKNSKERPTYP 306 S + + + P++P+ + + + ++C + + R T Sbjct: 242 GSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQ 299 >3VHK-A nrPDB Length = 368 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 41/167 (24%), Positives = 76/167 (45%), Gaps = 10/167 (5%) Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + + L + + K +E L S+ IHRD+ N+L++ VK+CDFG++ + Sbjct: 196 FLTLEHLICYSFQVAKGMEFLASR-KCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 254 Query: 209 AKTIDAGCK---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPF 264 + +MAPE I + Y+++SD+WS G+ + E+ PY Sbjct: 255 DYVRKGDARLPLKWMAPETI----FDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKID- 309 Query: 265 QQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 ++ + ++E + D + E C +RPT+ EL++H Sbjct: 310 EEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 93.4 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 45/121 (37%), Gaps = 7/121 (5%) Query: 44 QNFEVKADDLEPIMELGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLLM 98 +E D L+ LGRGA+G V + + + +AVK ++ E + L+ Sbjct: 22 SKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMS 81 Query: 99 DLDISMRTVDCPFTVTFYGALFRE-GDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILG 156 +L I + V GA + G + + +E +L + + ++ Sbjct: 82 ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGAR 141 Query: 157 K 157 Sbjct: 142 F 142 >6BFN-A nrPDB Length = 342 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 64/338 (18%), Positives = 118/338 (34%), Gaps = 68/338 (20%) Query: 25 TSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI 84 S P IS G NF +++L ++G G +G V + + + AVKR+ Sbjct: 3 MGSRPFPFCWPLCEISRGTHNF---SEEL----KIGEGGFGCVYRAVMRNT--VYAVKRL 53 Query: 85 RATVNSQE---QKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELM-DTSLDKFY 140 + + + ++ L +++ + P V F G + G + + + SL+ Sbjct: 54 KENADLEWTAVKQSFLTEVE-QLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL 112 Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFG 199 + I + +A++ LH S+IH D+K SNVL++ K+ DFG Sbjct: 113 HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG 172 Query: 200 ISGY---------LVDSVAKTIDA-GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE 249 ++ + VA+T G Y+ E I +V +D +S G+ ++E Sbjct: 173 LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKT----GRLAVDTDTFSFGVVVLE 228 Query: 250 LAILRFPYDSWGTPFQQLKQVVE-----------------------------------EP 274 + + G + LK +VE + Sbjct: 229 TLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKK 288 Query: 275 SPQLPADKFSAE----FVDFTSQCLKKNSKERPTYPEL 308 E CL + +K RP ++ Sbjct: 289 HLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQV 326 >4BTK-A nrPDB Length = 337 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 113/271 (41%), Gaps = 16/271 (5%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 V D + + ++G G +G + + + + + +A+K Q ++ L M++ + + Sbjct: 52 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKL 108 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 F G E ++ M+L +L + T+ ++ I++++ Sbjct: 109 QGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLS--TTLRLGKQILESI 166 Query: 167 EHLHSKLSVIHRDVKPSNV----LINALGQVKMCDFGISGYLVDSV----AKTIDAGCKP 218 E +HS + +HRD+KPSN L + + M DFG++ ++ AG + Sbjct: 167 EAIHS-VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRG 225 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 + +N N++ D+WSL ++E A+ + P+ +Q+ + E+ ++ Sbjct: 226 TVRYASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKEKYEHRM 283 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 +EF F + +P Y +M Sbjct: 284 LLKHMPSEFHLFLDHIASLDYFTKPDYQLIM 314 >4LFI-A nrPDB Length = 374 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 54/343 (15%), Positives = 120/343 (34%), Gaps = 82/343 (23%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAV----------------------- 81 ++ D E ++GRG Y V + + S + + Sbjct: 34 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 93 Query: 82 -KRIRATVNSQEQKRLLMDLDISMRTVD----------CPFTVTFYGALFRE--GDVWIC 128 K T+ Q+ + + ++ + + + + + Sbjct: 94 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 153 Query: 129 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN 188 E +D + + + + ++KAL++ HS + ++HRDVKP NV+I+ Sbjct: 154 FEYVDNVDFRIL------YPKLTDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVMID 206 Query: 189 A-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 ++++ D+G++ + ++ + + + PE + ++ + Y D+WS G + Sbjct: 207 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELL---VDYRMYDYSLDLWSFGTML 263 Query: 248 IELAILRFPYDSWGTPFQQLKQVVE------------EPSPQLPADKFS----------- 284 + R P+ + QL ++V+ + LP + + Sbjct: 264 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 323 Query: 285 ------------AEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 E +D L+ + +ER T E M HP+F Sbjct: 324 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >4NFN-A nrPDB Length = 309 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 113/271 (41%), Gaps = 16/271 (5%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 106 V D + + ++G G +G + + + + + +A+K Q ++ L M++ + + Sbjct: 17 YVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV---ESAQQPKQVLKMEVAVLKKL 73 Query: 107 VDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 F G E ++ M+L +L + T+ ++ I++++ Sbjct: 74 QGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLS--TTLRLGKQILESI 131 Query: 167 EHLHSKLSVIHRDVKPSNV----LINALGQVKMCDFGISGYLVDSV----AKTIDAGCKP 218 E +HS + +HRD+KPSN L + + M DFG++ ++ AG + Sbjct: 132 EAIHS-VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRG 190 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 + +N N++ D+WSL ++E A+ + P+ +Q+ + E+ ++ Sbjct: 191 TVRYASVNAHKNRE-MGRHDDLWSLFYMLVEFAVGQLPWRKIKDK-EQVGMIKEKYEHRM 248 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 +EF F + +P Y +M Sbjct: 249 LLKHMPSEFHLFLDHIASLDYFTKPDYQLIM 279 >2CHL-A nrPDB Length = 351 Score = 151 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 127/311 (40%), Gaps = 38/311 (12%) Query: 36 KACISIGNQNFEVKAD-------DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATV 88 + + +G +N ++ + ++G G +G + +++ + + +A+K + Sbjct: 8 SSGVDLGTENLYFQSMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMK 66 Query: 89 NSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQ 148 + Q L + + D V ++G + + +EL+ SL+ + + Sbjct: 67 SRAPQLHLEYRFYKQLGSGDGIPQVYYFGPCGKYNA--MVLELLGPSLEDLFDLCD---R 121 Query: 149 TIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-----VKMCDFGISGY 203 T + IA+ ++ +E++HSK ++I+RDVKP N LI G + + DF ++ Sbjct: 122 TFSLKTVLMIAIQLISRMEYVHSK-NLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKE 180 Query: 204 LVDSVAKTID--------AGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 +D K G YM+ IN L ++ S + D+ +LG + Sbjct: 181 YIDPETKKHIPYREHKSLTGTARYMS---INTHLGKEQ-SRRDDLEALGHMFMYFLRGSL 236 Query: 256 PY-----DSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P+ D+ +Q++ ++ + F E + + + E+P Y L + Sbjct: 237 PWQGLKADTLKERYQKIGDTKRATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRK 295 Query: 311 HPFFTLHESKG 321 F L + KG Sbjct: 296 -LFTDLFDRKG 305 >4LQP-A nrPDB Length = 508 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 45/195 (23%), Positives = 89/195 (45%), Gaps = 13/195 (6%) Query: 17 KEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKA--------DDLEPIMELGRGAYGVVE 68 + E TS + S+ S+G + + +D + +G+GA+G V Sbjct: 60 RVELETELTSHNWSEERKSRQLSSLGKKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVR 119 Query: 69 KMRHVPSGQIMAVKR-IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWI 127 ++ +G+I A+K +++ + ++Q + + D P+ V+ Y + +++ Sbjct: 120 LVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYL 179 Query: 128 CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187 ME + ++ + Q ED+ + A+E +H KL IHR +KP N+LI Sbjct: 180 IMEFLPGGD---LMTMLIRWQLFTEDVTRFYMAECILAIETIH-KLGFIHRAIKPDNILI 235 Query: 188 NALGQVKMCDFGISG 202 + G +K+ DFG+S Sbjct: 236 DIRGHIKLSDFGLST 250 Score = 91.9 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 33/110 (30%), Positives = 47/110 (42%), Gaps = 12/110 (10%) Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 G Y+APE +GY + D WSLG M E I P+ S TP + +++ Sbjct: 321 YSTVGTPDYIAPEI----FLYQGYGQECDWWSLGAIMYECLIGWPPFCSE-TPQETYRKI 375 Query: 271 VE-EPSPQLPAD-KFSAEFVDFTSQCLKKNSKERP----TYPELMQHPFF 314 + E + Q P D S E D + L + +R E+ HPFF Sbjct: 376 MNFEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFF 424 >2H34-A nrPDB Length = 309 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 100/255 (39%), Gaps = 15/255 (5%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI-SMRTVDCPF 111 +GRG G V + +I+A+K + T++S R M + + + P Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V + +G +++ M L++ ++ + + I I AL+ Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVD---LAAMLRRQGPLAPPRAVAIVRQIGSALDAA-H 151 Query: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS--VAKTIDAGCKPYMAPERINPEL 229 HRDVKP N+L++A + DFGI+ D G YMAPER + Sbjct: 152 AAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS--- 208 Query: 230 NQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 + + ++DI++L + E PY D + Q + PS P F Sbjct: 209 -ESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRP--GIPVAF 265 Query: 288 VDFTSQCLKKNSKER 302 ++ + KN ++R Sbjct: 266 DAVIARGMAKNPEDR 280 >4IAN-A nrPDB Length = 358 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 66/348 (18%), Positives = 122/348 (35%), Gaps = 77/348 (22%) Query: 32 DLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPS-GQIMAVKRIRATVNS 90 D + ++IG EV G+G + V + R Q +AVK IR N Sbjct: 15 DAEGYYRVNIG----EVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRN--NE 68 Query: 91 QEQKRLLMDLDISMRTVDCP-----FTVTFYGALFREGDVWICMELMDTSLDKFYKQVID 145 QK L +L+ + D + + + + + + E + +L + K+ Sbjct: 69 LMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKK-YG 127 Query: 146 KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQV-KMCDFGISGYL 204 K + + + + AL+ L + +++H D+KP N+L+N + K+CDFG + ++ Sbjct: 128 KDVGLHIKAVRSYSQQLFLALKLL-KRCNILHADIKPDNILVNESKTILKLCDFGSASHV 186 Query: 205 VDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD------ 258 D+ + Y APE I K Y D+WS+G T+ EL + + Sbjct: 187 ADNDITPYLV-SRFYRAPEIIIG----KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNH 241 Query: 259 --------SWGTPFQQLKQVVEEPSPQ--------LPADKFSAE---------------F 287 P + +++ V + + DK + Sbjct: 242 MLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLL 301 Query: 288 VDFT--------------------SQCLKKNSKERPTYPELMQHPFFT 315 D Q L + +R + + +QH F Sbjct: 302 ADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQ 349 >2X7G-A nrPDB Length = 389 Score = 146 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 63/365 (17%), Positives = 117/365 (32%), Gaps = 109/365 (29%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC-- 109 I +LG G + V + + +A+K +++ + E + L +R D Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSD 91 Query: 110 PF---TVTFYGALFREG----DVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 P V G V + E++ L K+ + Q +P + I + Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWI--IKSNYQGLPVRCVKSIIRQV 149 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLI----------------------------------- 187 ++ L++LHSK +IH D+KP N+L+ Sbjct: 150 LQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPA 209 Query: 188 ------------NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYS 235 +VK+ D G + ++ + I + Y + E + GYS Sbjct: 210 ADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQ--TRQYRSIEVLIGA----GYS 263 Query: 236 VKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEE----PSPQLPADKFSAE 286 +DIWS ELA + + + + + ++E P + K+S E Sbjct: 264 TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSRE 323 Query: 287 FV------------------------------------DFTSQCLKKNSKERPTYPELMQ 310 F DF L+ ++R + E ++ Sbjct: 324 FFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLR 383 Query: 311 HPFFT 315 HP+ Sbjct: 384 HPWLN 388 >2CMW-A nrPDB Length = 310 Score = 146 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 117/287 (40%), Gaps = 31/287 (10%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT-VDCPFT 112 ++G G +G + +++ + + +A+K + + Q L + + + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 V ++G + + +EL+ SL+ + +T + IA+ ++ +E++HSK Sbjct: 62 VYYFGPCGKYNA--MVLELLGPSLEDLFDLCD---RTFTLKTVLMIAIQLLSRMEYVHSK 116 Query: 173 LSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVDSVAKTID--------AGCKPY 219 ++I+RDVKP N LI G + + DFG++ +D K G Y Sbjct: 117 -NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEEP 274 M+ IN L ++ S + D+ +LG + P+ D+ +Q++ Sbjct: 176 MS---INTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNT 231 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 + + F E + + + E+P Y L F L E KG Sbjct: 232 PIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRT-LFTDLFEKKG 277 >2C47-A nrPDB Length = 313 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 118/288 (40%), Gaps = 30/288 (10%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPF 111 + ++G G +G + +++ + + +A+K + + Q L + + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 112 TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 V ++G + + +EL+ SL+ + +T + IA+ ++ +E++H+ Sbjct: 64 QVYYFGPCGKYNA--MVLELLGPSLEDLFDLCD---RTFTLKTVLMIAIQLITRMEYVHT 118 Query: 172 KLSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVDSVAKTID--------AGCKP 218 K S+I+RDVKP N L+ G + + DFG++ +D K G Sbjct: 119 K-SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 177 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQLKQVVEE 273 YM+ IN L ++ S + D+ +LG + P+ D+ +Q++ Sbjct: 178 YMS---INTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRA 233 Query: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG 321 ++ + F E + + + E+P Y L + F L + G Sbjct: 234 TPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRK-LFTDLFDRSG 280 >2QLU-A nrPDB Length = 314 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 112/298 (37%), Gaps = 51/298 (17%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR-T 106 V L+ + RG +G V K + + +AVK Q+++ + +I Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMND--FVAVKIFPL----QDKQSWQSEREIFSTPG 65 Query: 107 VDCPFTVTFYGALFREG----DVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVS 161 + + F A R ++W+ D SL + KG I + L +A + Sbjct: 66 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYL-----KGNIITWNELCHVAET 120 Query: 162 IVKALEHLHS----------KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA-- 209 + + L +LH K S+ HRD K NVL+ + + DFG++ Sbjct: 121 MSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPG 180 Query: 210 -KTIDAGCKPYMAPERINPELNQKGYSV-KSDIWSLGITMIELAILR-----------FP 256 G + YMAPE + +N + + + D++++G+ + EL P Sbjct: 181 DTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLP 240 Query: 257 YDSW---GTPFQQLKQVV--EEPSPQLPADKF-SAEFVDF---TSQCLKKNSKERPTY 305 ++ ++L++VV ++ P + +C +++ R + Sbjct: 241 FEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4M69-B nrPDB Length = 283 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 46/244 (18%), Positives = 102/244 (41%), Gaps = 20/244 (8%) Query: 79 MAVKRIRAT-VNSQEQKRLLMDLDI-SMRTVDCPFTVTFYGALFREG----DVWICMELM 132 + +K S R + +I +M+ D P + +G + + I ME Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 94 Query: 133 DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ 192 + ++++D+ + + + + + + L LH +HR++ S+ L+ Q Sbjct: 95 ELGT---LRELLDREKDLTMSVRSLLVLRAARGLYRLH-HSETLHRNISSSSFLVAGGYQ 150 Query: 193 VKMCDFGISG-----YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 VK+ F +S K + Y++PER+ Y +K++I+S GI + Sbjct: 151 VKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPF--CLYDIKAEIYSFGIVL 208 Query: 248 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYP 306 E+A + P++ G ++++++V E Q P + ++C +RP+ Sbjct: 209 WEIATGKIPFE--GCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVD 266 Query: 307 ELMQ 310 +++ Sbjct: 267 GILE 270 >4WUA-A nrPDB Length = 401 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 59/367 (16%), Positives = 118/367 (32%), Gaps = 111/367 (30%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK--RLLMDLDISMRTVDC 109 I +LG G + V + + +A+K +++ + E + + + + Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPND 101 Query: 110 PF---TVTFYGALF----REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 P V + + E++ L K+ + +G +P + KI + Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLP--CVKKIIQQV 159 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLIN---------------------------------- 188 ++ L++LH+K +IH D+KP N+L++ Sbjct: 160 LQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPA 219 Query: 189 ---------------ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG 233 +VK+ D G + ++ + I + Y + E + G Sbjct: 220 TAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQ--TRQYRSLEVLIGS----G 273 Query: 234 YSVKSDIWSLGITMIELAILRFPYDSWG-----TPFQQLKQVVEE----PSPQLPADKFS 284 Y+ +DIWS ELA + ++ + ++E P + A K+S Sbjct: 274 YNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYS 333 Query: 285 AEFV------------------------------------DFTSQCLKKNSKERPTYPEL 308 EF DF L+ ++R T E Sbjct: 334 KEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAEC 393 Query: 309 MQHPFFT 315 ++HP+ Sbjct: 394 LRHPWLN 400 >4BTF-A nrPDB Length = 469 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 46/244 (18%), Positives = 102/244 (41%), Gaps = 20/244 (8%) Query: 79 MAVKRIRAT-VNSQEQKRLLMDLDI-SMRTVDCPFTVTFYGALFREG----DVWICMELM 132 + +K S R + +I +M+ D P + +G + + I ME Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 280 Query: 133 DTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ 192 + ++++D+ + + + + + + L LH +HR++ S+ L+ Q Sbjct: 281 ELGT---LRELLDREKDLTMSVRSLLVLRAARGLYRLH-HSETLHRNISSSSFLVAGGYQ 336 Query: 193 VKMCDFGISG-----YLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITM 247 VK+ F +S K + Y++PER+ Y +K++I+S GI + Sbjct: 337 VKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPF--CLYDIKAEIYSFGIVL 394 Query: 248 IELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-ADKFSAEFVDFTSQCLKKNSKERPTYP 306 E+A + P++ G ++++++V E Q P + ++C +RP+ Sbjct: 395 WEIATGKIPFE--GCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVD 452 Query: 307 ELMQ 310 +++ Sbjct: 453 GILE 456 >4L00-A nrPDB Length = 304 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 110/299 (36%), Gaps = 31/299 (10%) Query: 47 EVKADDLEPIMELGRGA-----YGVVEKMRHVP-SGQIMAVKRIRATVNSQEQKRLLM-- 98 + DL LGRG G + + + + +K I ++ + L Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF 80 Query: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 + MR V V YG R+ + + E ++ + K + K+ Sbjct: 81 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH--RKSDVLTTPWKFKV 138 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ-------VKMCDFGISGYLVDSVAKT 211 A + AL +L K ++H +V N+L+ G +K+ D GI ++ Sbjct: 139 AKQLASALSYLEDK-DLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECI 197 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQLKQV 270 P++APE + K SV +D WS G T+ E+ P T ++ + Sbjct: 198 ER---IPWIAPECVEDS---KNLSVAADKWSFGTTLWEICYNGEIPLKD-KTLIEKERFY 250 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVK 329 P P+ E D ++C+ + +RP + +M+ E + D+ S K Sbjct: 251 ESRCRPVTPS---CKELADLMTRCMNYDPNQRPFFRAIMRD--INKLEEQNPDIVSEKK 304 >4XHH-A nrPDB Length = 403 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 56/275 (20%), Positives = 108/275 (39%), Gaps = 29/275 (10%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL-DISMRTVDC 109 ++G G++G + ++ SG+ +A+ R+ + + Q + V Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYLSGGVGI 65 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 PF ++G + ++L+ SL+ + K + +A+ ++ ++++ Sbjct: 66 PFI-RWFG--REGEYNAMVIDLLGPSLEDLFNYCHRK---FSFKTVIMLALQMICRVQYI 119 Query: 170 HSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVD--------SVAKTIDAGCKP 218 H + S IHRD+KP N L+ V + DFG+S D G Sbjct: 120 HGR-SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTAR 178 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEP-- 274 Y + +N L + S + D+ SLG +I P+ T Q+ +++E+ Sbjct: 179 YAS---VNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLC 234 Query: 275 -SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 S + EF ++ + C ERP Y L Sbjct: 235 ISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYL 269 >3G2F-A nrPDB Length = 336 Score = 143 bits (361), Expect = 9e-35, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 120/317 (37%), Gaps = 49/317 (15%) Query: 39 ISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLM 98 + + D+L+ + +GRG YG V K + +AVK + ++ + Sbjct: 1 MEAAASEPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKV----FSFANRQNFIN 54 Query: 99 DLDI-SMRTVDCPFTVTFY---GALFREG--DVWICMELM-DTSLDKFYKQVIDKGQTIP 151 + +I + ++ F + +G + + ME + SL K+ T Sbjct: 55 EKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSL-----HTSD 109 Query: 152 EDILGKIAVSIVKALEHLHSKLS--------VIHRDVKPSNVLINALGQVKMCDFGISGY 203 ++A S+ + L +LH++L + HRD+ NVL+ G + DFG+S Sbjct: 110 WVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMR 169 Query: 204 LV---------DSVAKTIDAGCKPYMAPERINPELNQKGYS---VKSDIWSLGITMIELA 251 L + A + G YMAPE + +N + + D+++LG+ E+ Sbjct: 170 LTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 229 Query: 252 ILRF-PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 + + P Q+ E + F D Q L K+RP +PE + Sbjct: 230 MRCTDLFPGESVPEYQMAFQTEVGNH--------PTFEDM--QVLVSREKQRPKFPEAWK 279 Query: 311 HPFFTLHESKGTDVASF 327 + K T + Sbjct: 280 ENSLAVRSLKETIEDCW 296 >4RT7-A nrPDB Length = 415 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 47/216 (21%), Positives = 89/216 (41%), Gaps = 22/216 (10%) Query: 98 MDLDISMRTVDCPFTVTFYG-ALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 ++ I D +G + E ++ E + + + + + + L Sbjct: 198 REVQIH---PDSDQISGLHGNSFHSEDEI----EYENQKRLEEEEDL----NVLTFEDLL 246 Query: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216 A + K +E L K S +HRD+ NVL+ VK+CDFG++ ++ + Sbjct: 247 CFAYQVAKGMEFLEFK-SCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNA 305 Query: 217 K---PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF-PYDSWGTPFQQLKQVVE 272 + +MAPE + + Y++KSD+WS GI + E+ L PY ++++ Sbjct: 306 RLPVKWMAPESLFEGI----YTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN-FYKLIQ 360 Query: 273 EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + E C +S++RP++P L Sbjct: 361 NGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 104 bits (260), Expect = 5e-23, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 45/118 (38%), Gaps = 5/118 (4%) Query: 45 NFEVKADDLEPIMELGRGAYGVVEKMRH---VPSGQ--IMAVKRIRATVNSQEQKRLLMD 99 +E ++LE LG GA+G V +G +AVK ++ +S E++ L+ + Sbjct: 59 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSE 118 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 L + + V GA G +++ E Y + + + K Sbjct: 119 LKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFK 176 >4F9B-A nrPDB Length = 361 Score = 138 bits (347), Expect = 5e-33, Method: Composition-based stats. Identities = 61/348 (17%), Positives = 109/348 (31%), Gaps = 98/348 (28%) Query: 53 LEPIMELGRGAYGVVEKMR---HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 + ++G G + V V + +A+K + T + R+ +L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP---IRIAAELQCLTVAGGQ 79 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 + + V I M ++ ++ +D ++ + + +++ KAL+ + Sbjct: 80 DNVMGVKYCFRKNDHVVIAMPYLE------HESFLDILNSLSFQEVREYMLNLFKALKRI 133 Query: 170 HSKLSVIHRDVKPSNVLINAL-GQVKMCDFGISGYLVDS--------------------- 207 H + ++HRDVKPSN L N + + DFG++ D+ Sbjct: 134 H-QFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNK 192 Query: 208 --------VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 AG + APE + NQ + D+WS G+ + L R+P+ Sbjct: 193 CSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQ---TTAIDMWSAGVIFLSLLSGRYPFYK 249 Query: 260 WGTPFQQLKQV--VEEPSPQLPADK-------FSAE--FVDFTSQC-------------- 294 L Q+ + + A K S E D C Sbjct: 250 ASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLT 309 Query: 295 ------------LKK---------------NSKERPTYPELMQHPFFT 315 + N R T E + HPFF Sbjct: 310 SDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFK 357 >5X18-A nrPDB Length = 295 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 51/257 (19%), Positives = 100/257 (38%), Gaps = 34/257 (13%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 + ++G G++GV+ + ++ +G +A+K + + + I T P Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGT---PNI 65 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 Y + ++L+ SL+ + G+ + ++AV ++ +E LH+ Sbjct: 66 PYAYYFGQEGLHNILVIDLLGPSLEDLFDWC---GRKFSVKTVVQVAVQMITLIEDLHAH 122 Query: 173 LSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVD--------SVAKTIDAGCKPY 219 +I+RD+KP N LI GQ + + DFG++ D K +G Y Sbjct: 123 -DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPF--QQLKQVVEEPSPQ 277 M+ IN L ++ S + D+ +LG P+ P Q+ +++ E+ Sbjct: 182 MS---INTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR-- 235 Query: 278 LPADKFSAEFVDFTSQC 294 S D Sbjct: 236 ------STNVYDLAQGL 246 >4NT4-A nrPDB Length = 312 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 56/301 (18%), Positives = 113/301 (37%), Gaps = 37/301 (12%) Query: 52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC-- 109 + ++G G +G + +++ + + +A+K + +L ++ Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHLEYRFYKLLGSHAD 69 Query: 110 ---PFTVTFYGALFREGDVW-ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 Y G + +EL+ SL+ + K + IA ++ Sbjct: 70 NAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARK---FSLKTVLMIAKQLLHR 126 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVD--------SVAKTI 212 +E++HS+ +I+RDVKP N LI + + DFG++ +D Sbjct: 127 IEYVHSR-HLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKS 185 Query: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY-----DSWGTPFQQL 267 G YM+ IN + ++ S + D+ +LG + P+ D+ +Q++ Sbjct: 186 LTGTARYMS---INTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 241 Query: 268 KQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKG-TDVAS 326 ++ D EF + + + E P Y + ++ F L + KG TD Sbjct: 242 GDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY-DFLRRLFQDLFDRKGYTDEGE 300 Query: 327 F 327 F Sbjct: 301 F 301 >4XHL-A nrPDB Length = 394 Score = 135 bits (339), Expect = 3e-32, Method: Composition-based stats. Identities = 53/272 (19%), Positives = 106/272 (38%), Gaps = 29/272 (10%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDL-DISMRTVDC 109 ++G G++G + ++ SG+ +A+ R+ + + Q + V Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYLSGGVGI 65 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHL 169 PF ++G + ++L+ SL+ + + + +A+ + ++++ Sbjct: 66 PFI-RWFG--REGEYNAMVIDLLGPSLEDLFNYCHRR---FSFKTVIMLALQMFCRIQYI 119 Query: 170 HSKLSVIHRDVKPSNVLIN---ALGQVKMCDFGISGYLVD--------SVAKTIDAGCKP 218 H + S IHRD+KP N L+ V + DFG+S D G Sbjct: 120 HGR-SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTAR 178 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEP-- 274 Y + +N L + S + D+ SLG +I P+ T Q+ +++E+ Sbjct: 179 YAS---VNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLN 234 Query: 275 -SPQLPADKFSAEFVDFTSQCLKKNSKERPTY 305 S + EF ++ + C E+P Y Sbjct: 235 VSVETLCSGLPLEFQEYMAYCKNLKFDEKPDY 266 >1CSN-A nrPDB Length = 298 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 100/274 (36%), Gaps = 29/274 (10%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 + +G G++GV+ + ++ + Q +A+K ++ + + + P Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV 71 Query: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 Y + ++L+ SL+ G+ + A ++ ++ +H K Sbjct: 72 ---YYFGQEGLHNVLVIDLLGPSLEDLLDLC---GRKFSVKTVAMAAKQMLARVQSIHEK 125 Query: 173 LSVIHRDVKPSNVLINALGQ-----VKMCDFGISGYLVDSV--------AKTIDAGCKPY 219 S+++RD+KP N LI + + DFG+ + D V K +G Y Sbjct: 126 -SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARY 184 Query: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW-----GTPFQQLKQVVEEP 274 M+ IN L ++ S + D+ +LG + P+ ++++ + + Sbjct: 185 MS---INTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQST 240 Query: 275 SPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 + F EF + P Y L Sbjct: 241 PLRELCAGFPEEFYKYMHYARNLAFDATPDYDYL 274 >5L2Q-C nrPDB Length = 320 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 45/281 (16%), Positives = 114/281 (40%), Gaps = 44/281 (15%) Query: 68 EKMRHVPSGQIMAVKRI------RATVNSQEQK--RLLMDLDISMRTVDC--PFTVTFYG 117 R + +K + + SQE++ ++L+ + S+ ++ V +G Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 118 ALFR------------------EGDVWICMELM-------DTSLDKFYKQVIDKGQTIPE 152 + + + ++ + T+ + + K + + E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL-GQVKMCDFGISGYLV-DSVAK 210 I +V+ +E LH K +++HRD+K N+++N ++ + +F + +LV + Sbjct: 153 RETVVIFYDVVRVVEALHQK-NIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLL 211 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 G Y++P+ ++ + SD+W+LG+ + + +FP+ Q+L + Sbjct: 212 KDQRGSPAYISPDVLSGRPYR---GKPSDMWALGVVLFTMLYGQFPFYDSIP--QELFRK 266 Query: 271 VEEPSPQLPAD-KFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 ++ +P D + S V + L + ++R ++++ Sbjct: 267 IKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >5USZ-A nrPDB Length = 289 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 106/281 (37%), Gaps = 31/281 (11%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSG-------QIMAVKRIRATVNSQEQKRLLMD 99 +++ +DL LG+G + + K G + +K + + + + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFF--E 61 Query: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKI 158 M + V YG + + E + SLD + K+ + I ++ Sbjct: 62 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN---CINILWKLEV 118 Query: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLI--------NALGQVKMCDFGISGYLVDSVAK 210 A + A+ L +IH +V N+L+ +K+ D GIS ++ K Sbjct: 119 AKQLAAAMHFLEENT-LIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLP---K 174 Query: 211 TIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 I P++ PE I N K ++ +D WS G T+ E+ Q K Sbjct: 175 DILQERIPWVPPECIE---NPKNLNLATDKWSFGTTLWEICSGGD--KPLSALDSQRKLQ 229 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 E QLPA K +AE + + C+ RP++ +++ Sbjct: 230 FYEDRHQLPAPK-AAELANLINNCMDYEPDHRPSFRAIIRD 269 >6DC0-A nrPDB Length = 292 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 44/251 (17%), Positives = 94/251 (37%), Gaps = 20/251 (7%) Query: 67 VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVW 126 V + + +G+ + K K + ++ + E + Sbjct: 22 VSRALCIHTGRELRCKVF-------PIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAY 74 Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + E + V + + + E+ ++ IV A+ H H ++ D+K + Sbjct: 75 VFFE---KDFGDMHSYVRSR-KRLREEEAARLFKQIVSAVAHCHQSA-IVLGDLKLRKFV 129 Query: 187 IN--ALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSL 243 + Q+++ + + + A + GC Y++PE +N G +D+WSL Sbjct: 130 FSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSG--KAADVWSL 187 Query: 244 GITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 G+ + L + R+P+ L + +P + S + L++ ER Sbjct: 188 GVMLYTLLVGRYPFHDSDPS--ALFSKIRRGQFCIP-EHISPKARCLIRSLLRREPSERL 244 Query: 304 TYPELMQHPFF 314 T PE++ HP+F Sbjct: 245 TAPEILLHPWF 255 >5CEK-A nrPDB Length = 263 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 44/251 (17%), Positives = 94/251 (37%), Gaps = 20/251 (7%) Query: 67 VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVW 126 V + + +G+ + K K + ++ + E + Sbjct: 25 VSRALCIHTGRELRCKVF-------PIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAY 77 Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + E + V + + + E+ ++ IV A+ H H ++ D+K + Sbjct: 78 VFFE---KDFGDMHSYVRSR-KRLREEEAARLFKQIVSAVAHCHQSA-IVLGDLKLRKFV 132 Query: 187 IN--ALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSL 243 + Q+++ + + + A + GC Y++PE +N G +D+WSL Sbjct: 133 FSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSG--KAADVWSL 190 Query: 244 GITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERP 303 G+ + L + R+P+ L + +P + S + L++ ER Sbjct: 191 GVMLYTLLVGRYPFHDSDPS--ALFSKIRRGQFCIP-EHISPKARCLIRSLLRREPSERL 247 Query: 304 TYPELMQHPFF 314 T PE++ HP+F Sbjct: 248 TAPEILLHPWF 258 >3REP-A nrPDB Length = 271 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 94/271 (34%), Gaps = 14/271 (5%) Query: 43 NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 102 N++ + L + +L G + K R G + VK ++ S + R + Sbjct: 2 NKHSGIDFKQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECP 59 Query: 103 SMRTVDCPFTVTFYGALFREG--DVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIA 159 +R P + GA + M SL + + + + K A Sbjct: 60 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTN--FVVDQSQAVKFA 117 Query: 160 VSIVKALEHLHSKLSVIHR-DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 + + + + LH+ +I R + +V+I+ ++ + S Sbjct: 118 LDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARIS----MADVKFSFQSPGRMYAPA 173 Query: 219 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 278 ++APE + + +D+WS + + EL P+ +K +E P + Sbjct: 174 WVAPEALQKKPEDTNR-RSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTI 232 Query: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 P S C+ ++ +RP + ++ Sbjct: 233 PP-GISPHVSKLMKICMNEDPAKRPKFDMIV 262 >5C01-A nrPDB Length = 342 Score = 123 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 94/250 (37%), Gaps = 22/250 (8%) Query: 70 MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICM 129 R + +K + + + + + M V +G R + + Sbjct: 101 GRDRGQELRVVLKVLDPSHH--DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 158 Query: 130 ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189 E ++ + + + +P +A + AL +L +K +++H +V N+L+ Sbjct: 159 EYVEHGPLDVWLR--RERGHVPMAWKMVVAQQLASALSYLENK-NLVHGNVCGRNILLAR 215 Query: 190 LGQ-------VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWS 242 LG +K+ D G+ + ++++ P++APE + N S D W Sbjct: 216 LGLAEGTSPFIKLSDPGVG---LGALSREERVERIPWLAPECLPGGANSL--STAMDKWG 270 Query: 243 LGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKE 301 G T++E+ P S ++ + +LP TSQCL + Sbjct: 271 FGATLLEICFDGEAPLQSRSPSEKEHFY---QRQHRLPEPSCPQ-LATLTSQCLTYEPTQ 326 Query: 302 RPTYPELMQH 311 RP++ +++ Sbjct: 327 RPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 94/250 (37%), Gaps = 22/250 (8%) Query: 70 MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICM 129 R + +K + + + + + M V +G R + + Sbjct: 78 GRDRGQELRVVLKVLDPSHH--DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVT 135 Query: 130 ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189 E ++ + + + +P +A + AL +L +K +++H +V N+L+ Sbjct: 136 EYVEHGPLDVWLR--RERGHVPMAWKMVVAQQLASALSYLENK-NLVHGNVCGRNILLAR 192 Query: 190 LGQ-------VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWS 242 LG +K+ D G+ + ++++ P++APE + N S D W Sbjct: 193 LGLAEGTSPFIKLSDPGVG---LGALSREERVERIPWLAPECLPGGANSL--STAMDKWG 247 Query: 243 LGITMIELAI-LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKE 301 G T++E+ P S ++ + +LP TSQCL + Sbjct: 248 FGATLLEICFDGEAPLQSRSPSEKEHFY---QRQHRLPEPSCPQ-LATLTSQCLTYEPTQ 303 Query: 302 RPTYPELMQH 311 RP++ +++ Sbjct: 304 RPSFRTILRD 313 >2PZI-A nrPDB Length = 681 Score = 121 bits (305), Expect = 3e-28, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 104/262 (39%), Gaps = 31/262 (11%) Query: 52 DLEPIMELGRGAYGVVEKMRHVP-SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 E + G G + +G+ + +K + + +++ Q + + + V P Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQ-FLAEVVHP 139 Query: 111 FTVTFYGALFREGDV-----WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 V + + +I ME + K KGQ +P + I+ A Sbjct: 140 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK-----RSKGQKLPVAEAIAYLLEILPA 194 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 L +LHS + +++ D+KP N+++ Q+K+ D G + ++S G + APE + Sbjct: 195 LSYLHS-IGLVYNDLKPENIMLTEE-QLKLIDLG-AVSRINSFGYLY--GTPGFQAPEIV 249 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 + G +V +DI+++G T+ L L P + + V+ P K Sbjct: 250 -----RTGPTVATDIYTVGRTLAAL-TLDLPTRNG--------RYVDGLPEDDPVLKTYD 295 Query: 286 EFVDFTSQCLKKNSKERPTYPE 307 + + + + ++R T E Sbjct: 296 SYGRLLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 104/262 (39%), Gaps = 31/262 (11%) Query: 52 DLEPIMELGRGAYGVVEKMRHVP-SGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 E + G G + +G+ + +K + + +++ Q + + + V P Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQ-FLAEVVHP 178 Query: 111 FTVTFYGALFREGDV-----WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 165 V + + +I ME + K KGQ +P + I+ A Sbjct: 179 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK-----RSKGQKLPVAEAIAYLLEILPA 233 Query: 166 LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 L +LHS + +++ D+KP N+++ Q+K+ D G + ++S G + APE + Sbjct: 234 LSYLHS-IGLVYNDLKPENIMLTEE-QLKLIDLG-AVSRINSFGYLY--GTPGFQAPEIV 288 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSA 285 + G +V +DI+++G T+ L L P + + V+ P K Sbjct: 289 -----RTGPTVATDIYTVGRTLAAL-TLDLPTRNG--------RYVDGLPEDDPVLKTYD 334 Query: 286 EFVDFTSQCLKKNSKERPTYPE 307 + + + + ++R T E Sbjct: 335 SYGRLLRRAIDPDPRQRFTTAE 356 >5X1R-A nrPDB Length = 302 Score = 120 bits (301), Expect = 9e-28, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 98/281 (34%), Gaps = 31/281 (11%) Query: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRL------------ 96 + ++ E +G G +G+V + + +A+K T ++ L Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKT 78 Query: 97 -------LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT 149 + + P + G ++ + + K + + Sbjct: 79 FQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNL--QAQQPEK 136 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVA 209 I E + ++ + A+ +H + +HRD+ N+ I + DFG + + +++ Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQE-GYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLS 195 Query: 210 KTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQ 269 + KP AP E + +DI++LG + L + P P ++ Sbjct: 196 DETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP------PVSVVRS 249 Query: 270 VVEEPSP--QLPADKFSAEFVDFTSQCLKKNSKERP-TYPE 307 + + P + +S E + + L ++RP T E Sbjct: 250 IEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDE 290 >4L68-A nrPDB Length = 340 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 97/263 (36%), Gaps = 29/263 (11%) Query: 65 GVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD 124 G K +P G +AVK + + + R M+ + + G E + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMN---QLWELRHSNLAPLLGFCVVEEE 109 Query: 125 VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS--KLSVIHRDVKP 182 ++ + M + + + +I + + L LH + ++H+++ Sbjct: 110 KFLVYKYMSNGT--LHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICS 167 Query: 183 SNVLINALGQVKMCDFGISGYLV-----DSVAKTIDAGCKPYMAPERINPELNQKGYSVK 237 S +LI+ ++ D G++ +V +S T D G Y+APE L S+K Sbjct: 168 SVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLA----SLK 223 Query: 238 SDIWSLGITMIELAI-----LRFPYD----SWGTPFQQLKQVVEEPSPQLPADKFSAE-- 286 D++ LG+ ++ELA + W + ++ E + E Sbjct: 224 GDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEIS 283 Query: 287 -FVDFTSQCLKKNSKERPTYPEL 308 FV+ C+ KER + + Sbjct: 284 KFVEIALNCVSSRPKERWSMFQA 306 >5UV4-A nrPDB Length = 311 Score = 116 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 123/304 (40%), Gaps = 36/304 (11%) Query: 37 ACISIGNQNFEVKADDLE--PIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK 94 + + + + A++L P +GR +G K + +G ++ VK ++ ++ +K Sbjct: 9 GDLHLFDNSVVFTAEELSCAPAEIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGF-AKSKK 66 Query: 95 RLLMDLDISMRTVDCPFTVTFYGALF--REGDVWICMELMD-TSLDKFYKQVIDKG-QTI 150 ++ + +V P V G + +E + + + D TSL + + ++ + Sbjct: 67 EFSREIK-KLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPL 125 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI-NALGQVKMCDFGISGYLVD--S 207 IA+ I + L++LH++ + H ++K SNVLI N+ + D+ + + Sbjct: 126 SAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGM 185 Query: 208 VAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD--------- 258 + ++AG Y PE ++ S+KSD+++ G+ ++EL + + Sbjct: 186 AEQVLNAGALGYSPPEF--SSTSKPCPSLKSDVYAFGVILLELLTGKIAGEIICMNDGVV 243 Query: 259 ---SWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK----------KNSKERPTY 305 W ++V E + + S L+ + + R + Sbjct: 244 DLTDWVRMLDLEERVSECYDRHITGVESSEGAPQALDGMLRIALRCIRSASERPEVRTVF 303 Query: 306 PELM 309 +L+ Sbjct: 304 EDLL 307 >5M07-A nrPDB Length = 276 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 103/262 (39%), Gaps = 43/262 (16%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ--KRLLMDLDISMRTVDCP 110 + LG A G V ++H A+K + + + ++ +R + +++ R P Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLF-HP 90 Query: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQ-TIPEDILGKIAVSIVKALEHL 169 + + +G +WI M+ +D + + D+ +P + I ++ AL++ Sbjct: 91 HILEVHDRGEFDGQLWIAMDYVDG--IDATQHMADRFPAVLPVGEVLAIVTAVAGALDYA 148 Query: 170 HSKLSVIHRDVKPSNVLINA----LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERI 225 H + ++HRDV P+NV++ + ++ + DFGI+ Y APE Sbjct: 149 HQR-GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPELS 194 Query: 226 NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGT-------------PFQQLKQVVE 272 ++D ++L +T I L P D T +L V+ Sbjct: 195 AGA----DVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLARLDGVLS 250 Query: 273 EPSPQLPADKF--SAEFVDFTS 292 PAD+F EF D + Sbjct: 251 RALATAPADRFGSCREFADAMN 272 >5OAT-A nrPDB Length = 411 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 100/317 (31%), Gaps = 71/317 (22%) Query: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQ-----IMAVKRIRATVNSQEQKRLLM---- 98 + +DL + +G GVV + A+K + + +L Sbjct: 8 ITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYR 67 Query: 99 -----------------DLDISMRTVD---CPFTVTFYGALFR----------------- 121 +++++ R P V + Sbjct: 68 ETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGR 127 Query: 122 EGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181 +++ M+ D +L F ++ + + H+ + + HRD+K Sbjct: 128 NMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLL------EGVAHM-TAHGIAHRDLK 180 Query: 182 PSNVLIN----ALGQVKMCDFGIS-------GYLVDSVAKTIDAGCKPYMAPERI---NP 227 N+L++ + + DFG L + + G MAPE I Sbjct: 181 SDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPG 240 Query: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEF 287 + YS K+D+W++G E+ P+ +G + E P+LP D+ Sbjct: 241 TFSVLNYS-KADLWAVGAIAYEIFNCHNPF--YGPSRLKNFNYKEGDLPKLP-DEVPTVI 296 Query: 288 VDFTSQCLKKNSKERPT 304 + LK+N +R Sbjct: 297 QALVANLLKRNPNKRLD 313 >4I94-A nrPDB Length = 300 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 99/243 (40%), Gaps = 18/243 (7%) Query: 66 VVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV 125 VV K + + + + +AVKR + + ++ L + + + G + + + Sbjct: 44 VVYKGK-LENQRRIAVKRFNRK-SWPDSRQFLEEAKAVGQLRNH-RMANLLGCCYEDEER 100 Query: 126 WICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 + E M +L K + Q + + ++A+ I +ALE+ SK ++ D+ Sbjct: 101 LLIAEFMPNETLAKHLFHW--ESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 185 VLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLG 244 VL + ++ FG+ D + + + + PE + + +S I+S G Sbjct: 159 VLFDDDANPRLSCFGLMKNSRDGKSYSTN---LAFTPPEYLRT----GRVTPESVIYSFG 211 Query: 245 ITMIELAILR--FPYDSWGTPFQQLKQVVEEPSP--QLPADKFSAEFVDFTSQCLKKNSK 300 +++L + P + + Q++ + Q +D E + S+CL+ + Sbjct: 212 TLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDD-GTELIRLASRCLQYEPR 270 Query: 301 ERP 303 ERP Sbjct: 271 ERP 273 >4OAU-C nrPDB Length = 699 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 107/308 (34%), Gaps = 49/308 (15%) Query: 16 PKEAFEQPQTSS--TPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHV 73 P +PQ+S +DL IG F + + + + G + + Sbjct: 311 PPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFID-EKYKIADT----SEGGIYLGFY- 364 Query: 74 PSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD 133 Q +AVK + R ++ + + VTFYG+ G +++C+ L + Sbjct: 365 -EKQEVAVKT-----FCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE 418 Query: 134 TSLDKFYKQVIDKGQTIPEDI-LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQ 192 +L+ + ED + SI KA++ LH H+D++P N+LI++ Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 193 VKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAI 252 + DF S + VK D+ LG ++ + Sbjct: 479 AHLADFDKSIKWAGDPQE-------------------------VKRDLEDLGRLVLYVV- 512 Query: 253 LRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHP 312 F+ LK E QL D E D + R +L+ HP Sbjct: 513 -----KKGSISFEDLKAQSNEEVVQLSPD---EETKDLIHRLFHPGEHVRDCLSDLLGHP 564 Query: 313 FFTLHESK 320 FF ES+ Sbjct: 565 FFWTWESR 572 >4JRN-A nrPDB Length = 372 Score = 104 bits (259), Expect = 7e-23, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 98/290 (33%), Gaps = 46/290 (15%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI---------------------------R 85 L LG G + V + V + + +AVK + Sbjct: 70 LVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAK 129 Query: 86 ATVNSQEQKRLLMDLDISMRTVD--CPFTVTFYGALFREGDVWICMEL---MDTSLDKFY 140 ++QE R ++ D+ M V + + M M + + Sbjct: 130 TAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVF 189 Query: 141 KQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGI 200 + ++ +K + ++ ++ ++H D+KP+N L+ G++ + DFG Sbjct: 190 GDASVNKSEFGLVVRMYLSSQAIKLVANVQAQ-GIVHTDIKPANFLLLKDGRLFLGDFGT 248 Query: 201 SGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSW 260 + +SV + I G Y PER + Y+ +D W LGIT+ + P Sbjct: 249 YR-INNSVGRAI--GTPGYEPPER-PFQATGITYTFPTDAWQLGITLYCIWCKERP---- 300 Query: 261 GTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 TP + + D L ++ ++R + ++ Sbjct: 301 -TPADGIWDYL----HFADCPSTPELVQDLIRSLLNRDPQKRMLPLQALE 345 >6J6I-B nrPDB Length = 351 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 92/260 (35%), Gaps = 33/260 (12%) Query: 77 QIMAVKRIRATV---NSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD 133 + +KR K + D+ +S R + + G + E + Sbjct: 82 RSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAE 141 Query: 134 TSLDKFYKQVIDKGQT--IPEDILGKIAVSIVKALEHLHSKLS--VIHRDVKPSNVLINA 189 VI G+ +P + KI I A+ +LH+ +IHRDVKP +V ++ Sbjct: 142 HGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDK 201 Query: 190 LGQVKMCDFGISGYLVDSVAKTIDA---GCKPYMAPERINPELNQKGY-SVKSDIWSLGI 245 K+ D S L + ++ G Y I+P ++ + + +D++S GI Sbjct: 202 NWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGY-----IDPLYHKTCFVTEYTDVYSFGI 256 Query: 246 TMIELAILRFPYDSWGT-PFQQLKQVVEEPSPQLPADKF--SAEFVD------------- 289 ++ + + + Q + +V E D+ D Sbjct: 257 CLLVIITGKPAIMTISDGDLQGILSLVRELCENGKLDEVIDPRLMKDITSGQRLQVEACV 316 Query: 290 -FTSQCLKKNSKERPTYPEL 308 +C K+ ++RP ++ Sbjct: 317 VLALRCCKERDEDRPKMIQV 336 >6EQI-C nrPDB Length = 433 Score = 98.4 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 48/323 (14%), Positives = 101/323 (31%), Gaps = 77/323 (23%) Query: 51 DDLEPIMELGRGAYGVVEKMRHVPSG-----QIMAVKRIRATVNSQEQKRLL----MDLD 101 D+L+ + +G VV + +AVK + +L + Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 102 ISM-------------------RTVDCPFTVTFYGALFREGD------------------ 124 +M R P V Y Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 125 ---------VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 175 +++ M+ D +L ++ + ++ + ++A+ H++ ++ Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQL-----LEAVAHMNIH-NI 188 Query: 176 IHRDVKPSNVLI-----NALGQVKMCDFGIS-------GYLVDSVAKTIDAGCKPYMAPE 223 HRD+K N+L+ +A + + DFG + G + MAPE Sbjct: 189 SHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPE 248 Query: 224 RINPELNQKGY--SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 N + + KSD+W++G E+ + P+ + + L + +E D Sbjct: 249 IANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPF--YDKTMKLLSKSYKEEDLPELPD 306 Query: 282 KFSAEFVDFTSQCLKKNSKERPT 304 + S L +++ +R Sbjct: 307 TIPFIIRNLVSNMLSRSTNKRLD 329 >4CI6-B nrPDB Length = 643 Score = 98.0 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 100/284 (35%), Gaps = 36/284 (12%) Query: 73 VPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG--ALFREGDVW--IC 128 +++A K R+ L I P +G + + + Sbjct: 66 KDKQRLVA-KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALL 124 Query: 129 MELMDT----SLDKFYKQVIDKGQTIPEDI---LGKIAVSIVKALEHLHSKLSVIHRDVK 181 M+ +D + +G+ E + IA ++ HL +K ++H D+K Sbjct: 125 MDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHL-AKAGIVHNDIK 183 Query: 182 PSNVLIN-ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI 240 P NV+ + A G+ + D G+ + + + APE + G S KSD+ Sbjct: 184 PGNVVFDRASGEPVVIDLGL----HSRSGEQPKGFTESFKAPEL---GVGNLGASEKSDV 236 Query: 241 WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFS----------AEFVDF 290 + + T++ F D P Q L+ + EP+ + + + + F Sbjct: 237 FLVVSTLLHGIEG-FEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRF 295 Query: 291 TSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334 + L ++ RP E H F S GT K IL D Sbjct: 296 ITDILGVSADSRPDSNEARLHEFL----SDGTIDEESAKQILKD 335 >5CLR-A nrPDB Length = 451 Score = 93.4 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 46/229 (20%), Positives = 90/229 (39%), Gaps = 20/229 (8%) Query: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGD--V 125 K+ + G+ +K ++ ++++ + D + G F E Sbjct: 96 FKVYALDDGKTYFLKSVK--IDAESLTEFTNEKDTLSKLG------RLVGTFFNEQTQVH 147 Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPE-DILGKIAVSIVKALEHLHSKLSVIHRDVKPSN 184 +I + YK + + + I +S+ ++ H L +IHRD+KP N Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHE-LGLIHRDLKPGN 206 Query: 185 VLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLG 244 ++++A Q + DFG S D K G Y+APE +N + + +S SD+++L Sbjct: 207 IMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPE-LNAQEDFIAFSQVSDLFALA 263 Query: 245 ITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQ 293 ++ EL P+ F ++ ++ L + A S Sbjct: 264 YSLDELFN---PFRQ--VKFAKVDIGIKNKHLVLLHAEIEACITGLMSN 307 >4O1O-A nrPDB Length = 717 Score = 92.6 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 49/248 (19%), Positives = 89/248 (35%), Gaps = 47/248 (18%) Query: 77 QIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSL 136 Q +AVKR R ++ + VTFYG+ + +C+ L + +L Sbjct: 370 QEVAVKRFSEGST-----RGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTL 424 Query: 137 DKFYKQVIDKGQTIPEDI-LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKM 195 + ED I S+ KA+ LH + H+D++P N+LI++ + Sbjct: 425 QEHLANHRGDAVPNEEDESARNILSSLFKAIGELH-RSGYSHQDLQPQNILIDSKNGTFL 483 Query: 196 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLG-ITMIELAILR 254 DF S + K +K D+ +LG + + + Sbjct: 484 ADFDKSIKWAEDPQK-------------------------IKRDLEALGLLVLYVVKKGD 518 Query: 255 FPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKK--NSKERPTYPELMQHP 312 +++ Q ++V++ E D N ++R + L+ HP Sbjct: 519 ISFETLKN--QSFEEVIQGSP--------DEETRDLIHHLFHPGDNVEDRLSS--LLAHP 566 Query: 313 FFTLHESK 320 FF ES+ Sbjct: 567 FFWSWESR 574 >5UU1-A nrPDB Length = 324 Score = 82.2 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 37/239 (15%), Positives = 84/239 (35%), Gaps = 35/239 (14%) Query: 47 EVKADDLEPIMELGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLLMDLD 101 +++ + ++G G +G++ + ++ V+ E K Sbjct: 12 DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAK 71 Query: 102 -------ISMRTVDCPFTVTFYGA----LFREGDVWICMELMDTSLDKFYKQVIDKGQTI 150 I + +D FYG+ ++ ME + L K + + T Sbjct: 72 KDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK----ISGQNGTF 127 Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN--ALGQVKMCDFGISGYLVD-- 206 + + ++ + ++ LE++H +H D+K +N+L+ QV + D+G+S Sbjct: 128 KKSTVLQLGIRMLDVLEYIHENE-YVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG 186 Query: 207 ------SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDS 259 + G + + S +SD+ LG M+ + P++ Sbjct: 187 NHKQYQENPRKGHNGTIEFTS----LDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 241 >2RSV-A nrPDB Length = 403 Score = 82.2 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 46/323 (14%), Positives = 115/323 (35%), Gaps = 61/323 (18%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYG 65 G + G+ P+ Q S+ R L + + + + + + + +G+G +G Sbjct: 1 GSSGSSGM--PRVKAAQAGRQSSAKRHLAEQFAVGEIITD--MAKKEWKVGLPIGQGGFG 56 Query: 66 VVEKMRHVPSGQIM---A-----------------VKRIRATVNSQEQKRLLMDLDISMR 105 + + S + + A +K + ++ ++ + ++ Sbjct: 57 CIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRK--LK 113 Query: 106 TVDCPFTVTFYGALFREGD----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 161 + P ++G+ + + ++ M+ + L K Y+ + + ++++ Sbjct: 114 YLGVP---KYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR---FSRKTVLQLSLR 167 Query: 162 IVKALEHLHSKLSVIHRDVKPSNVLIN--ALGQVKMCDFGISGYLVD--------SVAKT 211 I+ LE++H +H D+K SN+L+N QV + D+G++ K Sbjct: 168 ILDILEYIHEHE-YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKR 226 Query: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 G + + I+ N S + D+ LG MI+ P++ + Sbjct: 227 CHDGTIEFTS---IDAH-NGVAPSRRGDLEILGYCMIQWLTGHLPWED---------NLK 273 Query: 272 EEPSPQLPADKFSAEFVDFTSQC 294 + + ++ +C Sbjct: 274 DPKYVRDSKIRYRENIASLMDKC 296 >2LAV-A nrPDB Length = 361 Score = 79.9 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 44/314 (14%), Positives = 111/314 (35%), Gaps = 59/314 (18%) Query: 15 IPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVP 74 +P+ Q S+ R L + + G ++ + + + +G+G +G + + Sbjct: 1 MPRVKAAQAGRQSSAKRHLAEQFAV--GEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMN 57 Query: 75 SGQIM---A-----------------VKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 S + + A +K + ++ ++ + ++ + P Sbjct: 58 SSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRK--LKYLGVP---K 112 Query: 115 FYGALFREGD----VWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 ++G+ + + ++ M+ + L K Y+ + + ++++ I+ LE++H Sbjct: 113 YWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR---FSRKTVLQLSLRILDILEYIH 169 Query: 171 SKLSVIHRDVKPSNVLIN--ALGQVKMCDFGISGYLVD--------SVAKTIDAGCKPYM 220 +H D+K SN+L+N QV + D+G++ K G + Sbjct: 170 EHE-YVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFT 228 Query: 221 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 280 + N S + D+ LG MI+ P++ + + + Sbjct: 229 S----IDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED---------NLKDPKYVRDSK 275 Query: 281 DKFSAEFVDFTSQC 294 ++ +C Sbjct: 276 IRYRENIASLMDKC 289 >4IX6-A nrPDB Length = 350 Score = 79.5 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 54/351 (15%), Positives = 112/351 (31%), Gaps = 80/351 (22%) Query: 33 LDSKACISIGNQNFEVKADDLEPI-MELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQ 91 L ++ + V+ D+ + LG G +G V + ++ ++ Sbjct: 1 LKARGGPKTLRRTPGVEPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVV----LKNAKADV 56 Query: 92 EQKRLLMDLDISMRTVDCPF----TVTFYGALF----REGDVWICMELMDTSLDK-FYKQ 142 L++ ++ + F G + G+++ + +L + + Sbjct: 57 MAAEELLECEMDVNYHVHANAKGTCARFMGCIELGAKDGGEIY------NGTLTEGLWLM 110 Query: 143 VIDKGQTIPEDILG----------------------KIAVSIVKALEHLHSKLSVIHRDV 180 ++G+ E ++ K ++ +L LH V+HRDV Sbjct: 111 WANEGENTVEALMRRGTAPLATAMACADATELGVTKKAMRELLGSLARLHE-CGVVHRDV 169 Query: 181 KPSNVLINAL--GQVKMCDFG---ISGYLVDSVAKTIDAG--CKPYM-APERINPELNQK 232 KP+N++ G +K+ D G + L +++ G Y A E Sbjct: 170 KPANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSP 229 Query: 233 GYSV-------------KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP 279 + + D WS G M++LA++ D+ F + V Sbjct: 230 RPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFR 289 Query: 280 ADKFSAEF---------------VDFTSQCLKKNSKERPTYPELMQHPFFT 315 +K S E+ D + ++ R + + H FF Sbjct: 290 GEK-SGEYGTMDFAALDANGGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >6EAS-A nrPDB Length = 308 Score = 73.4 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 44/291 (15%), Positives = 94/291 (32%), Gaps = 39/291 (13%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHV-PSGQIMAVKRIRATVN---SQ 91 S+ E +D I+ G+ + SG +AV T S+ Sbjct: 27 TGVPSLKRSELETACEDFSNII----GSTSTCMLYKGTLSSGVEIAVASSLVTSAKDWSK 82 Query: 92 EQKRLLMDLDISMRTVDCPFTVTFYGALFREGDV--WICMELMDTSLDKFYKQVIDKGQT 149 E + ++ V + G E + E F + + + Sbjct: 83 ENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTL-FEHLHVREAEK 141 Query: 150 IPEDILGKIAVSIVKALEHLHS-KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSV 208 + +I++ I LEH+H + R+ + V + K+ D + D+ Sbjct: 142 LDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDL---EFWNDAK 198 Query: 209 AKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ--- 265 + +P+ E + Y G+ ++E+ R P P + Sbjct: 199 GHNSTTNNELAFSPDM---EDIVRKY---------GMVLLEILTGRVPSSEDDGPLENWV 246 Query: 266 --------QLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL 308 +L+++++ PS + + + C+ ++ K+RP E+ Sbjct: 247 SRYFEGGMRLEELID-PSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >6G4J-A nrPDB Length = 315 Score = 71.5 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 94/234 (40%), Gaps = 35/234 (14%) Query: 53 LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT 112 +LG+GA G+V G +A+K S + + ++++ +++ + Sbjct: 28 YTLRKQLGKGANGIVYLA-ETSDGH-VALKV------SDDSLSITSEVNV-LKSFSKAQS 78 Query: 113 VTFYGALFREGDVWI----------CMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 VT + F D +I ME + L K V DKG + + + + + Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKGA----EWIPVLMIQL 132 Query: 163 VKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSVAKTIDAGCKPYMA 221 + +L LH + I D+KP N+++ +++ D G + ++ + + + Y Sbjct: 133 LSSLSVLHQQ-GWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYW- 190 Query: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 275 + D++++ + MI ++ + + P +QL+ ++E Sbjct: 191 ------GYGTRKAEPSYDLFAVAMIMIN-SVHKKEFKKTNQPKEQLRSLIEGNP 237 >2JII-A nrPDB Length = 352 Score = 68.4 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 38/207 (18%), Positives = 81/207 (39%), Gaps = 21/207 (10%) Query: 120 FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179 ++ ++ + + SL + + E + ++A ++ ALE LH +H + Sbjct: 128 HQDKYRFLVLPSLGRSLQSALD--VSPKHVLSERSVLQVACRLLDALEFLHENE-YVHGN 184 Query: 180 VKPSNVLIN--ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP-----ERINPELNQK 232 V N+ ++ QV + +G + S +P E I+ +L++ Sbjct: 185 VTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGS--RSPHEGDLEFISMDLHKG 242 Query: 233 -GYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLK----QVVEEPSPQL-PADKF--- 283 G S +SD+ SLG M++ P+ + + + + V++P P + P + Sbjct: 243 CGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRP 302 Query: 284 SAEFVDFTSQCLKKNSKERPTYPELMQ 310 S + + +E+P Y L Sbjct: 303 SETLQKYLKVVMALTYEEKPPYAMLRN 329 >5DMZ-A nrPDB Length = 365 Score = 65.7 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 42/273 (15%), Positives = 88/273 (32%), Gaps = 34/273 (12%) Query: 59 LGRGAYGVVEKMR-----HVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 LG GA+ V + + Q +K ++ N E ++ ++ F + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLK-VQKPANPWEFYIGTQLMERLKPSMQHMF-M 130 Query: 114 TFYGALFREGDVWICMELMDTS--LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 FY A + + EL L+ + +P+ ++ A+ ++ +E +H Sbjct: 131 KFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHD 190 Query: 172 KLSVIHRDVKPSNVLINALGQ-----------VKMCDFGIS---GYLVDSVAKTIDAGCK 217 +IH D+KP N ++ + + D G S T Sbjct: 191 -CEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETS 249 Query: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQ 277 + E ++ K ++ + D + + T+ + + + + E + Sbjct: 250 GFQCVEMLS----NKPWNYQIDYFGVAATVYCMLFGTY----MKVKNEGGECKPEGLFRR 301 Query: 278 LPADKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 LP EF + P+ L Q Sbjct: 302 LPHLDMWNEFFHVMLNI--PDCHHLPSLDLLRQ 332 >6BHC-A nrPDB Length = 438 Score = 64.9 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 87/273 (31%), Gaps = 48/273 (17%) Query: 79 MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE---------------- 122 AVK ++ ++E ++ L + G E Sbjct: 86 YAVKICKS--KAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQR 143 Query: 123 GDVWICM-ELMDTSLDKFYKQVID---KGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178 V + E+ ++ F + + K + E + + + + LEHL V H Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHL-KPYHVTHC 202 Query: 179 DVKPSNVLI---NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMA--------PERI-- 225 D++ N+L+ G + FG + S T A PE + Sbjct: 203 DLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRD 260 Query: 226 ----NPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLP-A 280 PE+ K D + GI + E+ L P+D P + ++ P++P Sbjct: 261 QSRLAPEIITATQYKKCDEFQTGILIYEMLHLPNPFDE--NPELKEREYTRADLPRIPFR 318 Query: 281 DKFSAEFVDFTSQCLKKNSKERP---TYPELMQ 310 +S S L N ER ++Q Sbjct: 319 SPYSRGLQQLASCLLNPNPSERILISDAKGILQ 351 >6EWX-A nrPDB Length = 484 Score = 64.5 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 28/200 (14%), Positives = 59/200 (29%), Gaps = 48/200 (24%) Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI------------------------ 187 E + + + + LEHL +IHRD+ N+L+ Sbjct: 209 ERRVCFLLLQLCNGLEHLKEH-GIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRC 267 Query: 188 -----------------NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELN 230 L ++ + +F + + +APE ++ Sbjct: 268 PSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSAS-Q 326 Query: 231 QKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + + D + GI + EL P++ ++ E+ P +S Sbjct: 327 YRKF----DEFQTGILIYELLHQPNPFEVRA-QLRERDYRREDLPPLPTLSLYSPGLQQL 381 Query: 291 TSQCLKKNSKERPTYPELMQ 310 L+ + +R E + Sbjct: 382 AHLLLEADPIKRIRIGEAKR 401 >5GZA-A nrPDB Length = 290 Score = 61.8 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 46/279 (16%), Positives = 87/279 (31%), Gaps = 56/279 (20%) Query: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 + +G+GA V GQ +A+ + + + + L +R + V Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADDFLHGLS----MLRALQSSHVV 81 Query: 114 TFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT---IPEDILGKIAVSIVKALEHLH 170 T G + E + + + ++A+ V L +LH Sbjct: 82 TLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLH 139 Query: 171 SKLSVIHRDVKPSN--------VLINALGQVKMCDFGISGYLVDSVAKTIDAG----CKP 218 S + I R + SN L+ + ++ D + V+ + G Sbjct: 140 SSPAGI-RVMCDSNDLHKTLSQFLLASDMRLLANDL-DALPEVEKGGLGVKCGHHELTGD 197 Query: 219 YMAPERINPELNQ--------KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQV 270 ++APE++ P GY K+DIW + P L V Sbjct: 198 FVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW------------KIP----DVTRFLLGDV 241 Query: 271 VEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + + +E +K + RPT E++ Sbjct: 242 LGGDVIHFHLFQIYSECK-------RKEAHMRPTAREVL 273 >5GZ9-A nrPDB Length = 305 Score = 60.7 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 33/215 (15%), Positives = 68/215 (31%), Gaps = 32/215 (14%) Query: 50 ADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDC 109 ++ + +G GA V +A+ R+ ++ L ++++ Sbjct: 33 RTEVRQLKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHGLQ----MLKSLQS 86 Query: 110 PFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTI---PEDILGKIAVSIVKAL 166 VT G +G I E ++ + + ++A+ V + Sbjct: 87 EHVVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSII 144 Query: 167 EHLHSKLSVIHRDVKPSN--------VLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP 218 +LH + R + SN L+ + + D + I G + Sbjct: 145 NYLH-HSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRE 203 Query: 219 ----YMAPERINPELNQKG--------YSVKSDIW 241 ++APE++ P Y+ K DIW Sbjct: 204 LHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6M7Z-A nrPDB Length = 319 Score = 60.7 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 37/187 (19%), Positives = 73/187 (39%), Gaps = 27/187 (14%) Query: 151 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK 210 + +A ++V AL+ LH L ++HR ++ ++ + G V + + + Sbjct: 142 SHPDVQVLAANMVAALKSLH-NLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRL 200 Query: 211 TIDAGCKPYMAPER-----INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQ 265 + + APE + L Q ++VKSD++SLG+ ++ Q Sbjct: 201 WVGFFGQE-TAPEIDRNFLADLALTQGRHTVKSDVYSLGV-------------AFRNLVQ 246 Query: 266 QLKQVVEEPSPQLPADKFSAEFVD-FTSQCLKKNSKERPTYPELMQHPFF------TLHE 318 L P + + E +D + + +++ RPT E+M+ P F + E Sbjct: 247 LLGNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEE 306 Query: 319 SKGTDVA 325 K Sbjct: 307 GKARPFR 313 >3BYV-A nrPDB Length = 377 Score = 56.8 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 35/258 (13%), Positives = 89/258 (34%), Gaps = 37/258 (14%) Query: 80 AVKRIRATVNSQEQKRLLMD---LDISMRTVDCPFTV-------TFYGALFREGDVWICM 129 A+K+++ V R + + + +R PF + E D+W+ Sbjct: 116 AIKQMKEEVLRLRLLRGIKNQKQAKVHLR-FIFPFDLVKDPQKKKMIRVRLDERDMWVLS 174 Query: 130 EL-----MDTSLDKFYKQVIDKG---QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181 M ++L F + ++ +++ ++ + +++ L LH ++H ++ Sbjct: 175 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLH-HYGLVHTYLR 233 Query: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGY------- 234 P +++++ G V + F +LV A+ + + + + PE + Sbjct: 234 PVDIVLDQRGGVFLTGF---EHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLM 290 Query: 235 SVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 294 + D W+LG+ + + P + + Sbjct: 291 TFSFDAWALGLVIYWIWCADLP-------ITKDAALGGSEWIFRSCKNIPQPVRALLEGF 343 Query: 295 LKKNSKERPTYPELMQHP 312 L+ ++R + M+ P Sbjct: 344 LRYPKEDRLLPLQAMETP 361 >4CYJ-A nrPDB Length = 438 Score = 56.8 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 24/147 (16%), Positives = 63/147 (42%), Gaps = 17/147 (11%) Query: 64 YGV---VEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF 120 +G V K ++ +G+ A++R+ + E + ++++ + + VT + Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNE--KAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 121 RE--GDVWICMEL----MDTSLDKFYKQVIDKGQT-----IPEDILGKIAVSIVKALEHL 169 GD + + +L + + Q I + +PE+ + I AL+ + Sbjct: 123 TREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTI 182 Query: 170 HSKLSVIHRDVKPSNVLINALGQVKMC 196 HS + R ++PS +++ + ++++ Sbjct: 183 HSN-RLAARCLEPSKIILTDINRIRLS 208 >3DZO-A nrPDB Length = 413 Score = 53.7 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 38/257 (14%), Positives = 88/257 (34%), Gaps = 36/257 (14%) Query: 80 AVKRIRATVNSQEQKRLLMD---LDISMRTVDCPFTV-------TFYGALFREGDVWICM 129 A+K+++ V R + + + +R PF + E D+W+ Sbjct: 121 AIKQMKEEVLRLRLLRGIKNQKQAKVHLR-FIFPFDLVKDPQKKKMIRVRLDERDMWVLS 179 Query: 130 EL-----MDTSLDKFYKQVIDKG---QTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVK 181 M ++L F + ++ +++ ++ + +++ L LH ++H ++ Sbjct: 180 RFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLH-HYGLVHTYLR 238 Query: 182 PSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG------YS 235 P +++++ G V + F +LV A + + + PE + G + Sbjct: 239 PVDIVLDQRGGVFLTGF---EHLVRDGASAVSPIGRGFAPPETTAERMLPFGQHHPTLMT 295 Query: 236 VKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCL 295 D W+LG+ + + P T L L Sbjct: 296 FAFDTWTLGLAIYWIWCADLP----NTDDAALGG---SEWIFRSCKNIPQPVRALLEGFL 348 Query: 296 KKNSKERPTYPELMQHP 312 + ++R + M+ P Sbjct: 349 RYPKEDRLLPLQAMETP 365 >6G38-A nrPDB Length = 357 Score = 51.4 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 29/213 (13%), Positives = 66/213 (30%), Gaps = 69/213 (32%) Query: 36 KACISIGNQNFEVKA------------------DDLEPIMELGRGAYGVVEKMRHVPSGQ 77 + + +G +N ++ + L+ ++G G +G V + + Sbjct: 8 SSGVDLGTENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT-- 65 Query: 78 IMAVKRIR-------ATVNSQEQKRLLMDLDISMRT----------------VDCPFTVT 114 +A+K I + + + +L ++ IS ++ V Sbjct: 66 PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQ 125 Query: 115 ------FYGA----------------LFREGDVWICMELMDTSLDKFYKQVIDKGQTIPE 152 A F++ ++I +E +D +Q+ K ++ Sbjct: 126 GSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGID--LEQMRTKLSSL-- 181 Query: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 I + +L + L HRD+ NV Sbjct: 182 ATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4AZV-A nrPDB Length = 569 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 W+ ME + + ++ G+ I + KI S++++L L K H DV+P NV Sbjct: 318 WLVMEKLPG---RLLSDMLAAGEEIDRE---KILGSLLRSLAAL-EKQGFWHDDVRPWNV 370 Query: 186 LINALGQVKMCDFG 199 +++A ++ DFG Sbjct: 371 MVDARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 7/74 (9%) Query: 126 WICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNV 185 W+ ME + + ++ G+ I + KI S++++L L K H DV+P NV Sbjct: 318 WLVMEKLPG---RLLSDMLAAGEEIDRE---KILGSLLRSLAAL-EKKGFWHDDVRPWNV 370 Query: 186 LINALGQVKMCDFG 199 +++A ++ DFG Sbjct: 371 MVDARQHARLIDFG 384 >2W1Z-A nrPDB Length = 368 Score = 49.1 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 22/181 (12%), Positives = 59/181 (32%), Gaps = 17/181 (9%) Query: 136 LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKM 195 L +++ ++ + +++ L ++H D + N+L++ G V + Sbjct: 174 LGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASL-QHYGLVHADFQVRNILLDQRGGVFL 232 Query: 196 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKG------YSVKSDIWSLGITMIE 249 F +LV A + + + PE + + D W+LG+ + Sbjct: 233 TGF---EHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYW 289 Query: 250 LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELM 309 + P ++ ++ + L+ + ++R + M Sbjct: 290 IWCADLP-NTEDAELGGIEWIYRR------CKNIPQPVRALLEGFLRYSKEDRLLPLQAM 342 Query: 310 Q 310 + Sbjct: 343 E 343 >4BWP-A nrPDB Length = 448 Score = 48.0 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 16/136 (11%), Positives = 37/136 (27%), Gaps = 35/136 (25%) Query: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR----EG 123 + H +G ++RI + L++ + + V + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVE---MWKKLQHTNVVQLREVFTTKAFGDN 123 Query: 124 DVWICMELMDTS---LDKFY-------------------------KQVIDKGQTIPEDIL 155 + + + S L K++ Q G +PE + Sbjct: 124 SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATI 183 Query: 156 GKIAVSIVKALEHLHS 171 I + + L+ +H Sbjct: 184 WSIIMQLTAGLKAIHH 199 >4CZY-B nrPDB Length = 429 Score = 46.4 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 43/116 (37%), Gaps = 14/116 (12%) Query: 68 EKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFRE----G 123 K ++ +G+ A++RI + E + ++++ + + VT + A E Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNE--KAILNVTKEWKKIINANIVTVHEAFTTEFFGDS 118 Query: 124 DVWICMELMDTS--LDKFY------KQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 + + S L + + IPE++L I AL +H+ Sbjct: 119 SLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHN 174 >5VE6-A nrPDB Length = 492 Score = 45.7 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 152 EDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLI 187 E + + + + LEHL +IHRD+ N+L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEH-GIIHRDLCLENLLL 241 Score = 44.1 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 40/117 (34%), Gaps = 8/117 (6%) Query: 195 MCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILR 254 + +F + + +APE ++ + + D + GI + EL Sbjct: 300 ISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSAS-QYRKF----DEFQTGILIYELLHQP 354 Query: 255 FPYDSWGTPFQQLKQVVEEPSPQLPA-DKFSAEFVDFTSQCLKKNSKERPTYPELMQ 310 P++ + + +E P LPA +S L+ + +R E + Sbjct: 355 NPFEVRAQLRE--RDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >3Q60-A nrPDB Length = 371 Score = 41.4 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 77/208 (37%), Gaps = 21/208 (10%) Query: 129 MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN 188 +EL+ ++LD Y D+G L + +++ +L SK ++H P N+ I Sbjct: 174 LELLFSTLDFVYVFRGDEGIL----ALHILTAQLIRLAANLQSK-GLVHGHFTPDNLFIM 228 Query: 189 ALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 G++ + D +S + Y E +N ++ + W LG+++ Sbjct: 229 PDGRLMLGD--VSALWKVGTRGPASSVPVTYAPREFLNASTAT--FTHALNAWQLGLSIY 284 Query: 249 ELAILRFPYDSWGTPFQQLKQVVEEPSPQLP---------ADKFSAEFVDFTSQCLKKNS 299 + L P+ G +K + PS ++P + L + Sbjct: 285 RVWCLFLPF---GLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDR 341 Query: 300 KERPTYPELMQHPFFTLHESKGTDVASF 327 + R E M+ P F +++ + S Sbjct: 342 RRRLLPLEAMETPEFLQLQNEISSSLST 369 >4WWA-A nrPDB Length = 261 Score = 39.9 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 33/174 (18%), Positives = 54/174 (31%), Gaps = 36/174 (20%) Query: 56 IMELGRGAYGVV-------EKMRHVPSGQIMAVK-----RIRATVNSQE--QKRLLMDLD 101 I + +GA +V R S Q +K R R Q + R L + Sbjct: 19 IAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESR 78 Query: 102 ISMRTVDCP--FTVTFYGALFREGDVWICMELMDTSL----------DKFYKQVIDKGQT 149 + + P G +W+ E + L + + D Sbjct: 79 LLAKLYLIPGLCVPQLIACDPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 Query: 150 IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG---QVKMCDFGI 200 + L K+ I L LH H D+ SN+++ G + DFG+ Sbjct: 137 LVATTLRKVGRQI--GL--LHWN-DYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >5YK0-A nrPDB Length = 452 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 57/181 (31%), Gaps = 61/181 (33%) Query: 65 GVVEKMRHVPSGQIMAVKR--------IRATVNSQEQ----------------------K 94 G V K G+ +AVK +RA + + ++ + Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 95 RLLMDLDISMR---------------TVDCPFTVTFYGALFREGDVWICMELMDT-SLDK 138 R M+LD + P V + E ++ + + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVV-------ASAPKVVIQEWIEGVPMAE 257 Query: 139 FYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198 + + + + +L ++ + +L ++H D P N ++ G++ + DF Sbjct: 258 IIRHGTTEQRDLIGTLLAELTFDAPR-------RLGLMHGDAHPGNFMLLPDGRMGIIDF 310 Query: 199 G 199 G Sbjct: 311 G 311 >3QRQ-A nrPDB Length = 267 Score = 37.9 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 19/48 (39%), Gaps = 4/48 (8%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKA 50 + G K K ++ + P + D D KA IG++N + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSENLYFQM 57 >3ENH-A nrPDB Length = 540 Score = 36.8 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 3/58 (5%) Query: 156 GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTID 213 IA I + + LH K VIH D+ SN + + + + DFG+ K +D Sbjct: 434 LDIAYKIGEIVGKLH-KNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVD 488 >6G18-v nrPDB Length = 552 Score = 34.9 bits (79), Expect = 0.053, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 26/79 (32%), Gaps = 10/79 (12%) Query: 120 FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179 + MEL++ V D E + + + + +IH D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKL----------ANHGLIHGD 228 Query: 180 VKPSNVLINALGQVKMCDF 198 N++++ + M DF Sbjct: 229 FNEFNLILDESDHITMIDF 247 >3URH-A nrPDB Length = 491 Score = 34.5 bits (78), Expect = 0.059, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 21/46 (45%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAV 81 + + +G +N ++ ++ +G G G V ++ G +AV Sbjct: 8 SSGVDLGTENLYFQSMMAYDLIVIGSGPGGYVCAIKAAQLGMKVAV 53 >1ZP9-A nrPDB Length = 258 Score = 34.5 bits (78), Expect = 0.063, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 48/113 (42%), Gaps = 10/113 (8%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + ME + +++ G+ + E + I +V+ ++ L+ + ++H D+ N++ Sbjct: 145 LLMEFIGEDELPAPT-LVELGRELKELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIM 203 Query: 187 INALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSD 239 +V D G + L +A++ Y+ + N Y VK+D Sbjct: 204 YID--KVYFIDMGQAVTLRHPMAES-------YLERDVRNIIRFFSKYGVKAD 247 >6FDN-A nrPDB Length = 320 Score = 34.1 bits (77), Expect = 0.080, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 26/79 (32%), Gaps = 10/79 (12%) Query: 120 FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179 + MEL++ V D E + + + + +IH D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKL----------ANHGLIHGD 228 Query: 180 VKPSNVLINALGQVKMCDF 198 N++++ + M DF Sbjct: 229 FNEFNLILDESDHITMIDF 247 >1TQM-A nrPDB Length = 282 Score = 33.7 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 36/81 (44%), Gaps = 12/81 (14%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + MEL+D K++ P+++L I + K H ++H D+ NVL Sbjct: 177 VLMELIDA------KELYRVRVENPDEVLDMILEEVAK---FYHR--GIVHGDLSQYNVL 225 Query: 187 INALGQVKMCDFGISGYLVDS 207 ++ G + + DF S + + Sbjct: 226 VSEEG-IWIIDFPQSVEVGEE 245 >2PZ1-A nrPDB Length = 466 Score = 33.7 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 25/75 (33%), Gaps = 7/75 (9%) Query: 108 DCPF-TVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKAL 166 + P V V+ E L K +D P + K + + + L Sbjct: 215 NHPNACVELSRLTKLSKYVYF-FEACRL-LQKMIDISLDGFLLTPVQKICKYPLQLAELL 272 Query: 167 EHLHSKLSVIHRDVK 181 ++ H + HRD K Sbjct: 273 KYTHPQ----HRDFK 283 >5ER0-A nrPDB Length = 518 Score = 33.3 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 29/101 (28%), Gaps = 26/101 (25%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 + G K K ++ + P + D D KA IG+ Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSMKV---------------- 53 Query: 63 AYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDIS 103 V H + A+K+I A E + IS Sbjct: 54 ---TVVGCTHAGT---FAIKQILAEHPDAEVTVYERNDVIS 88 >3E46-A nrPDB Length = 253 Score = 33.3 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 22/61 (36%), Gaps = 8/61 (13%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ----NFEVKADDLEPIME 58 + G K K ++ + P + D D KA IG++ N V+ E Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSEFDMANIAVQRIKREFKEV 69 Query: 59 L 59 L Sbjct: 70 L 70 >6EF6-A nrPDB Length = 354 Score = 32.6 bits (73), Expect = 0.22, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 33/87 (37%), Gaps = 19/87 (21%) Query: 130 ELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKL----------SVIHRD 179 E ++ + +G E L A + LH KL +IH D Sbjct: 178 EHCLGDTPRWGRWQDAEGVGASETALLTRAQDL------LHRKLEEYGSGPDRYGLIHAD 231 Query: 180 VKPSNVLINA---LGQVKMCDFGISGY 203 ++ +N+L+++ + + DF G+ Sbjct: 232 LRLANLLVDSSTPQRTITVIDFDDCGF 258 >4MZD-A nrPDB Length = 488 Score = 32.2 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 17/42 (40%), Gaps = 4/42 (9%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFE 47 G K K ++ + P + D D KA IG+Q + Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSQPLK 40 >6C7N-A nrPDB Length = 613 Score = 32.2 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 16/39 (41%), Gaps = 4/39 (10%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ 44 G K K ++ + P + D D KA IG++ Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSE 37 >3KIA-A nrPDB Length = 387 Score = 32.2 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 17/42 (40%), Gaps = 4/42 (9%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ 44 + G K K ++ + P + D D KA IG++ Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSE 51 >4ESA-B nrPDB Length = 146 Score = 32.2 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 21/69 (30%), Gaps = 9/69 (13%) Query: 62 GAYGVVEKMRHVPSGQIMA---VKRI----RATVNSQEQKRLLMDLDISMRTVDC--PFT 112 G++G + + Q +A +K + RA N K + +L I P Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHSEKLHVDPDN 102 Query: 113 VTFYGALFR 121 Sbjct: 103 FKLLADCLT 111 >6G5I-z nrPDB Length = 568 Score = 32.2 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 29/71 (40%), Gaps = 4/71 (5%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + M + + K + E ++ + +++ + ++ ++H D+ N+L Sbjct: 275 LVMSFIGKDD---MPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNML 331 Query: 187 INALGQVKMCD 197 + G V + D Sbjct: 332 YHGGG-VYIID 341 >4OTP-A nrPDB Length = 352 Score = 31.8 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 29/71 (40%), Gaps = 4/71 (5%) Query: 127 ICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 + M + + K + E ++ + +++ + ++ ++H D+ N+L Sbjct: 133 LVMSFIGKDD---MPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNML 189 Query: 187 INALGQVKMCD 197 + G V + D Sbjct: 190 YHGGG-VYIID 199 >3AIW-A nrPDB Length = 564 Score = 31.8 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 7/60 (11%), Positives = 19/60 (31%), Gaps = 9/60 (15%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS---------TPPRDLDSKACISIGNQNFEVKADDL 53 + G K K ++ + P + TP + + + + +++ D Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTDDDDKAMAGTPSKPSEPIGPVFTKLKPWQIPKRDW 73 >2DGA-A nrPDB Length = 565 Score = 31.4 bits (70), Expect = 0.53, Method: Composition-based stats. Identities = 7/60 (11%), Positives = 19/60 (31%), Gaps = 9/60 (15%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS---------TPPRDLDSKACISIGNQNFEVKADDL 53 + G K K ++ + P + TP + + + + +++ D Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTDDDDKAMAGTPSKPAEPIGPVFTKLKPWQIPKRDW 73 >4B8O-A nrPDB Length = 490 Score = 31.4 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 15/39 (38%), Gaps = 4/39 (10%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ 44 G K K ++ + P + D D KA IG+ Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSS 37 >5XJN-A nrPDB Length = 455 Score = 31.0 bits (69), Expect = 0.72, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 17/45 (37%), Gaps = 4/45 (8%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFE 47 + G K K ++ + P + D D KA IG+ + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGSTSHH 54 >5M85-A nrPDB Length = 215 Score = 30.6 bits (68), Expect = 0.87, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 16/41 (39%), Gaps = 4/41 (9%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGN 43 + G K K ++ + P + D D KA IG+ Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGS 50 >5YPT-A nrPDB Length = 429 Score = 30.6 bits (68), Expect = 0.89, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 15/38 (39%), Gaps = 4/38 (10%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGN 43 G K K ++ + P + D D KA IG+ Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGS 36 >3KCC-A nrPDB Length = 260 Score = 30.2 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 16/41 (39%), Gaps = 4/41 (9%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGN 43 + G K K ++ + P + D D KA IG+ Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGS 50 >3PK1-A nrPDB Length = 189 Score = 30.2 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 15/38 (39%), Gaps = 4/38 (10%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGN 43 G K K ++ + P + D D KA IG+ Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMADIGS 36 >2YAD-A nrPDB Length = 171 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 18/46 (39%), Gaps = 4/46 (8%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKAD 51 G K K ++ + P + D D KA + ++ E+ + Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMAHMSQKHTEMVLE 44 >6B3J-R nrPDB Length = 491 Score = 29.9 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 IA +I+ HLH + IH ++ S +L Sbjct: 167 ALVIASAILLGFRHLHCTRNYIHLNLFASFIL 198 >5VEW-A nrPDB Length = 455 Score = 29.9 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 IA +I+ HLH + IH ++ S +L Sbjct: 32 ALVIASAILLGFRHLHCTRNYIHLNLFASFIL 63 >5VAI-R nrPDB Length = 461 Score = 29.9 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 IA +I+ HLH + IH ++ S +L Sbjct: 197 ALVIASAILLGFRHLHCTRNYIHLNLFASFIL 228 >5NX2-A nrPDB Length = 422 Score = 29.9 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 155 LGKIAVSIVKALEHLHSKLSVIHRDVKPSNVL 186 IA +I+ HLH + IH ++ S +L Sbjct: 139 ALVIASAILLGFRHLHCTRNYIHLNLFASFIL 170 >3F7W-A nrPDB Length = 288 Score = 29.5 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 31/68 (45%), Gaps = 5/68 (7%) Query: 131 LMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH---SKLSVIHRDVKPSNVLI 187 + + + ++ D+G P D+ ++ ++ AL+HL + IH D+ NVL Sbjct: 145 YAEQRILPYLRRAADRGALTPGDV--RLVEKVLDALDHLAGDPEPPARIHGDLWNGNVLW 202 Query: 188 NALGQVKM 195 G V + Sbjct: 203 QDDGAVVI 210 >1T9B-A nrPDB Length = 677 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 9/57 (15%), Positives = 18/57 (31%), Gaps = 1/57 (1%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMEL 59 + G K K ++ + P + D + S E A+ + +L Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTD-DDDKAMGSAPSFNVDPLEQPAEPSKLAKKL 69 >2X8T-A nrPDB Length = 471 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 6/44 (13%), Positives = 14/44 (31%), Gaps = 1/44 (2%) Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIP 151 P V + ++G +W+ + + G +P Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGGIF-ILEMNPKTGFPLP 207 >4H05-A nrPDB Length = 273 Score = 29.1 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 24/66 (36%), Gaps = 7/66 (10%) Query: 175 VIHRDVKPSNVLIN-ALGQVK-MCDFGISGYLVDSVAKTIDAGCK-----PYMAPERINP 227 V H D+ P NVL++ +V + D G G + P+ PE Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFGPECSAA 245 Query: 228 ELNQKG 233 L + G Sbjct: 246 FLREYG 251 >6OGD-C nrPDB Length = 633 Score = 29.1 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 13/115 (11%), Positives = 38/115 (33%), Gaps = 13/115 (11%) Query: 74 PSGQIMA--VKRIRATVNSQEQKRLLMDLDISMR----TVDCPFTVTFYGALFREGDVWI 127 G+ +K +R+ ++S+ ++ I+ + ++++ Sbjct: 364 KDGENYVLLIKELRSALDSRFGYSNRKEISIACSGVKAKLKKSNIDQLVANGLD--NIYL 421 Query: 128 C-MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV----IH 177 + T + + +S A+++LH++L + IH Sbjct: 422 MSYDFFGTIWADYIGHHTNLYSPKDPGEQELFDLSAEAAIDYLHNELGIPMEKIH 476 >4DWS-C nrPDB Length = 546 Score = 29.1 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 13/115 (11%), Positives = 38/115 (33%), Gaps = 13/115 (11%) Query: 74 PSGQIMA--VKRIRATVNSQEQKRLLMDLDISMR----TVDCPFTVTFYGALFREGDVWI 127 G+ +K +R+ ++S+ ++ I+ + ++++ Sbjct: 277 KDGENYVLLIKELRSALDSRFGYSNRKEISIACSGVKAKLKKSNIDQLVANGLD--NIYL 334 Query: 128 C-MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV----IH 177 + T + + +S A+++LH++L + IH Sbjct: 335 MSYDFFGTIWADYIGHHTNLYSPKDPGEQELFDLSAEAAIDYLHNELGIPMEKIH 389 >5TWT-A nrPDB Length = 331 Score = 29.1 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 5/36 (13%), Positives = 11/36 (30%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKAC 38 + G K K ++ + P + +C Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTQLSSTFYDTSC 49 >2JND-A nrPDB Length = 119 Score = 29.1 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 5/23 (21%), Positives = 9/23 (39%) Query: 6 GKKRNPGLKIPKEAFEQPQTSST 28 G K K ++ + P +T Sbjct: 3 GMKETAAAKFERQHMDSPDLGTT 25 >4QRX-A nrPDB Length = 363 Score = 29.1 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 5/34 (14%), Positives = 11/34 (32%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSK 36 + G K K ++ + P + +D Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTDDDDKMDFS 47 >5OVL-A nrPDB Length = 300 Score = 28.7 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 4/26 (15%), Positives = 9/26 (34%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSST 28 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTE 39 >5XTU-A nrPDB Length = 360 Score = 28.7 bits (63), Expect = 3.5, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 16/39 (41%), Gaps = 4/39 (10%) Query: 6 GKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQ 44 G K K ++ + P + D D KA ++ ++ Sbjct: 3 GMKETAAAKFERQHMDSPDLGT----DDDDKAMVAEFDR 37 >6DEO-A nrPDB Length = 682 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >5ZVL-A nrPDB Length = 171 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >5YNL-A nrPDB Length = 362 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >5CFZ-A nrPDB Length = 305 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >4B7O-A nrPDB Length = 745 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >4AIP-A nrPDB Length = 742 Score = 28.7 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >1E1H-A nrPDB Length = 287 Score = 28.7 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >1NL3-A nrPDB Length = 922 Score = 28.3 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 11/56 (19%), Positives = 17/56 (30%), Gaps = 15/56 (26%) Query: 7 KKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRG 62 K K ++ + P + PR AD L ++ LG G Sbjct: 1 MKETAAAKFERQHMDSPDLGTLVPRGSM---------------ADILSKLLRLGEG 41 >5W21-B nrPDB Length = 226 Score = 28.3 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >6MRG-A nrPDB Length = 580 Score = 28.3 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 4/22 (18%), Positives = 8/22 (36%) Query: 6 GKKRNPGLKIPKEAFEQPQTSS 27 G K K ++ + P + Sbjct: 3 GMKETAAAKFERQHMDSPDLGT 24 >3LY9-A nrPDB Length = 372 Score = 28.3 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 4/22 (18%), Positives = 8/22 (36%) Query: 6 GKKRNPGLKIPKEAFEQPQTSS 27 G K K ++ + P + Sbjct: 3 GMKETAAAKFERQHMDSPDLGT 24 >2AKJ-A nrPDB Length = 608 Score = 28.3 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 4/25 (16%), Positives = 9/25 (36%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSS 27 + G K K ++ + P + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGT 38 >3LV4-A nrPDB Length = 456 Score = 27.9 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 16/45 (35%), Gaps = 3/45 (6%) Query: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDK-GQTIP 151 P V + + G +W+ S F ++ K G +P Sbjct: 142 KHPNVVDPHTFFDQNGKLWMV--YGSYSGGIFILEMDKKTGFPLP 184 >6IBP-A nrPDB Length = 420 Score = 27.9 bits (61), Expect = 6.0, Method: Composition-based stats. Identities = 4/37 (10%), Positives = 13/37 (35%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACI 39 + G K K ++ + P + +++ + Sbjct: 14 RGSGMKETAAAKFERQHMDSPDLGTDDDDKMNTAIKV 50 >2X86-A nrPDB Length = 357 Score = 27.9 bits (61), Expect = 6.5, Method: Composition-based stats. Identities = 4/23 (17%), Positives = 8/23 (34%) Query: 3 QSKGKKRNPGLKIPKEAFEQPQT 25 + G K K ++ + P Sbjct: 14 RGSGMKETAAAKFERQHMDSPDL 36 >5XQL-A nrPDB Length = 291 Score = 27.9 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 32/76 (42%), Gaps = 3/76 (3%) Query: 83 RIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWIC-MELMDTSLDKFYK 141 +R +++ ++RLL +LD ++ T+ + + + ME ++ Sbjct: 110 TLREEISA--RQRLLAELDRTLATLAHWRIRNMHARIVERPAFSVVGMEYFGSAPGDTIG 167 Query: 142 QVIDKGQTIPEDILGK 157 Q+ ++ +I GK Sbjct: 168 QLWERFIPREHEIAGK 183 >4D0L-A nrPDB Length = 566 Score = 27.5 bits (60), Expect = 7.3, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 43/108 (39%), Gaps = 12/108 (11%) Query: 184 NVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYSVKSDIWS 242 N+L++A G + DFG +++ S + + + + E ++ G D+++ Sbjct: 443 NILLDAEGHIIHIDFG---FILSSSPRNLGFETSAFKLTTEFVDVMGGLDG-----DMFN 494 Query: 243 LGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + + Q+ +++++ S QLP S+ + Sbjct: 495 YYKML--MLQGLIAARKHMDKVVQIVEIMQQGS-QLPCFHGSSTIRNL 539 >6GL3-A nrPDB Length = 386 Score = 27.5 bits (60), Expect = 7.5, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 43/108 (39%), Gaps = 12/108 (11%) Query: 184 NVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYSVKSDIWS 242 N+L++A G + DFG +++ S + + + + E ++ G D+++ Sbjct: 264 NILLDAEGHIIHIDFG---FILSSSPRNLGFETSAFKLTTEFVDVMGGLDG-----DMFN 315 Query: 243 LGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + + Q+ +++++ S QLP S+ + Sbjct: 316 YYKML--MLQGLIAARKHMDKVVQIVEIMQQGS-QLPCFHGSSTIRNL 360 >5C4G-E nrPDB Length = 529 Score = 27.5 bits (60), Expect = 8.3, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 43/108 (39%), Gaps = 12/108 (11%) Query: 184 NVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPY-MAPERINPELNQKGYSVKSDIWS 242 N+L++A G + DFG +++ S + + + + E ++ G D+++ Sbjct: 406 NILLDAEGHIIHIDFG---FILSSSPRNLGFETSAFKLTTEFVDVMGGLDG-----DMFN 457 Query: 243 LGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDF 290 + + Q+ +++++ S QLP S+ + Sbjct: 458 YYKML--MLQGLIAARKHMDKVVQIVEIMQQGS-QLPCFHGSSTIRNL 502 >3HV0-A nrPDB Length = 393 Score = 27.5 bits (60), Expect = 8.7, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 21/48 (43%) Query: 14 KIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGR 61 KI K AF Q + R L + + + Q +D E + E+G+ Sbjct: 288 KIMKYAFSGGQATEEEQRRLGANLDVDVSWQYLRFLMEDDEKLEEIGK 335 >2FV8-A nrPDB Length = 207 Score = 27.5 bits (60), Expect = 9.1, Method: Composition-based stats. Identities = 6/34 (17%), Positives = 16/34 (47%) Query: 36 KACISIGNQNFEVKADDLEPIMELGRGAYGVVEK 69 + + +G +N ++ + ++ +G GA G Sbjct: 8 SSGVDLGTENLYFQSMIRKKLVVVGDGACGKTCL 41 >5LJ3-H nrPDB Length = 591 Score = 27.2 bits (59), Expect = 9.5, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 14/28 (50%), Gaps = 1/28 (3%) Query: 177 HRDVKPSNVLINALGQVK-MCDFGISGY 203 HRD+ N+LI K + DF ++ Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQ 68 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.151 0.455 Lambda K H 0.267 0.0466 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,156,173 Number of Sequences: 36641 Number of extensions: 589726 Number of successful extensions: 6063 Number of sequences better than 10.0: 557 Number of HSP's better than 10.0 without gapping: 853 Number of HSP's successfully gapped in prelim test: 184 Number of HSP's that attempted gapping in prelim test: 1874 Number of HSP's gapped (non-prelim): 1181 length of query: 334 length of database: 10,336,785 effective HSP length: 98 effective length of query: 236 effective length of database: 6,745,967 effective search space: 1592048212 effective search space used: 1592048212 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.5 bits)