BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P51857 (326 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3G1R-A nrPDB 681 0.0 1Q5M-A nrPDB 407 e-114 4JQA-A nrPDB 401 e-112 2FVL-A nrPDB 394 e-110 5JM5-A nrPDB 391 e-109 2HE8-A nrPDB 387 e-108 1AFS-A nrPDB 379 e-106 5UXF-A nrPDB 350 4e-97 1ZUA-X nrPDB 331 2e-91 3RX4-A nrPDB 315 1e-86 1C9W-A nrPDB 306 8e-84 1DLA-A nrPDB 302 1e-82 3O3R-A nrPDB 301 4e-82 1FRB-A nrPDB 296 8e-81 1HQT-A nrPDB 278 2e-75 2ALR-A nrPDB 274 3e-74 4GAC-A nrPDB 273 9e-74 4HBK-A nrPDB 259 1e-69 3WCZ-A nrPDB 237 6e-63 5JH1-A nrPDB 212 2e-55 3H7R-A nrPDB 211 4e-55 1QWK-A nrPDB 211 4e-55 1K8C-A nrPDB 208 2e-54 3H7U-A nrPDB 206 1e-53 4GIE-A nrPDB 204 4e-53 5Z6T-A nrPDB 202 1e-52 5ZCM-A nrPDB 199 1e-51 2BGQ-A nrPDB 193 7e-50 4F40-A nrPDB 190 6e-49 1VBJ-A nrPDB 190 7e-49 3KRB-A nrPDB 187 5e-48 1VP5-A nrPDB 181 3e-46 4IJC-A nrPDB 169 2e-42 1MZR-A nrPDB 165 3e-41 3D3F-A nrPDB 162 3e-40 4MHB-A nrPDB 159 1e-39 1A80-A nrPDB 157 4e-39 3UP8-A nrPDB 156 9e-39 4OTK-A nrPDB 147 7e-36 3WG6-A nrPDB 142 2e-34 4H8N-A nrPDB 137 8e-33 1PYF-A nrPDB 65 4e-11 1PZ1-A nrPDB 57 2e-08 4R9O-A nrPDB 45 4e-05 1LQA-A nrPDB 40 0.001 1OG6-A nrPDB 40 0.002 2C91-A nrPDB 36 0.027 2BP1-A nrPDB 35 0.060 5E5H-A nrPDB 35 0.061 4EHI-A nrPDB 33 0.14 3QUR-A nrPDB 33 0.15 4F5V-A nrPDB 32 0.27 5Y0V-A nrPDB 32 0.29 5GHK-A nrPDB 32 0.46 2AEV-A nrPDB 31 0.65 3EB3-A nrPDB 31 0.71 5YXE-A nrPDB 30 1.7 5ZF1-A nrPDB 29 2.5 3HJE-A nrPDB 28 7.2 >3G1R-A nrPDB Length = 346 Score = 681 bits (1758), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 60 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN Sbjct: 21 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 80 Query: 61 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 120 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE Sbjct: 81 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 140 Query: 121 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 180 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL Sbjct: 141 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 200 Query: 181 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 240 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK Sbjct: 201 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 260 Query: 241 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 300 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE Sbjct: 261 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 320 Query: 301 ALNKNVRFVELLMWRDHPEYPFHDEY 326 ALNKNVRFVELLMWRDHPEYPFHDEY Sbjct: 321 ALNKNVRFVELLMWRDHPEYPFHDEY 346 >1Q5M-A nrPDB Length = 322 Score = 407 bits (1047), Expect = e-114, Method: Compositional matrix adjust. Identities = 191/319 (59%), Positives = 239/319 (74%), Gaps = 1/319 (0%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 R+ LSDG+ IP++G GTY+ P+ PK + K+AID G+RHID AY Y+NE EVG A Sbjct: 5 QRVALSDGHFIPVLGFGTYA-PEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLA 63 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 IR KIA+G V+REDIFY KLW T H PE+VRP+LE +L+ LQLDYVDLYII P A KP Sbjct: 64 IRSKIADGTVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKP 123 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 G EI P DE+GK ++ ++CATWEAME CKDAGL KS+GVSNFNRRQLE+ILNKPGLK+ Sbjct: 124 GVEIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 183 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 KPV NQVECHPY Q KLL+FC+ IV+ AYS LG+ R P WV+ S+P LL+D L+ +L Sbjct: 184 KPVCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGAL 243 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVR 307 K++ +T A I LR+ +QRG+VV+ KSF +RIKEN Q+F+F L E+MK I++LN+N R Sbjct: 244 AKKHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFR 303 Query: 308 FVELLMWRDHPEYPFHDEY 326 +V HP YPF DEY Sbjct: 304 YVTADFAIGHPNYPFSDEY 322 >4JQA-A nrPDB Length = 331 Score = 401 bits (1030), Expect = e-112, Method: Compositional matrix adjust. Identities = 185/317 (58%), Positives = 243/317 (76%), Gaps = 1/317 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P PK +VK+AI+ G+ HID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 KIA+G V+REDIFY KLW+ +H PE+VRP LER+L+ LQLDYVDLY+I P++ KPG+ Sbjct: 67 SKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E+ P+DENGK L+ +LCATWEAME CKDAGL KS+GVSNFN R LE+ILNKPGLK+KP Sbjct: 127 EVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKP 186 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQVECHPYF Q KLL FC+ DIV+ AYS LG+ R WV+ +SP LL+D +L +L K Sbjct: 187 VCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAK 246 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT EEMK I+ LN+NVR++ Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYL 306 Query: 310 ELLMWRDHPEYPFHDEY 326 L ++ P YPF DEY Sbjct: 307 TLDIFAGPPNYPFSDEY 323 >2FVL-A nrPDB Length = 324 Score = 394 bits (1012), Expect = e-110, Method: Compositional matrix adjust. Identities = 181/319 (56%), Positives = 239/319 (74%), Gaps = 1/319 (0%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 R+ L+DG+ +P++G GTY+ P+ P+ K+AI+ G+RHID AY+Y NE +VG A Sbjct: 7 QRVELNDGHFMPVLGFGTYAPPE-VPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLA 65 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 IR KIA+G V+REDIFY KLW T P+MV+P LE +L+ LQLDYVDLY++ PMA KP Sbjct: 66 IRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKP 125 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 G+ P+DENGK ++ +L ATWE ME CKDAGL KS+GVSNFN RQLE+ILNKPGLK+ Sbjct: 126 GETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKY 185 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 KPV NQVECHPY Q KLL FC+ DIV+ A+S LGT R+ +WV+ +SP LL+D +L +L Sbjct: 186 KPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCAL 245 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVR 307 K++ +T A I LR+ +QRGVVV+ KS+N +RI+EN Q+F+F LT E+MK ++ LN+N R Sbjct: 246 AKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYR 305 Query: 308 FVELLMWRDHPEYPFHDEY 326 +V + DHP+YPF DEY Sbjct: 306 YVVMDFLMDHPDYPFSDEY 324 >5JM5-A nrPDB Length = 332 Score = 391 bits (1005), Expect = e-109, Method: Compositional matrix adjust. Identities = 178/317 (56%), Positives = 239/317 (75%), Gaps = 1/317 (0%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L+DG+ +P++G GTY+ P+ P+ K+AI+ G+RHID A++Y NE +VG AIR Sbjct: 8 VKLNDGHFMPVLGFGTYAPPE-VPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 KIA+G V+REDIFY KLW+T H PE+VRP LE +L+ QLDYVDLY+I PM+ KPG+ Sbjct: 67 SKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGE 126 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E+ P DENGK ++ +LC TWEAME CKDAGL KS+GVSNFNRRQLE+ILNKPGLK+KP Sbjct: 127 ELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 186 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQVECHPYF + KLL FC+ DIV+ AYS LG+ R+ WV+ +SP LL+D +L +L K Sbjct: 187 VCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAK 246 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT E+MK I+ L++N+ + Sbjct: 247 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYF 306 Query: 310 ELLMWRDHPEYPFHDEY 326 + HP YP+ DEY Sbjct: 307 NSDSFASHPNYPYSDEY 323 >2HE8-A nrPDB Length = 323 Score = 387 bits (993), Expect = e-108, Method: Compositional matrix adjust. Identities = 180/324 (55%), Positives = 236/324 (72%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +++ H + L+DGN IP++G GT + P PK K+AID G+ H D A +Y E Sbjct: 1 MNSKCHCVILNDGNFIPVLGFGT-ALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTED 59 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 VGEAIR KIA+G VRREDIFY K+W T+ PE+VR +LER+L+ LQ DYVDLY+I P Sbjct: 60 HVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYP 119 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 MA KPG+E +P DE+GK ++ + +LCATWEAME CKDAGL KS+GVSNFN RQLE+ILNK Sbjct: 120 MALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNK 179 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECHPY Q KLL FC+ DIV+ AY LGT R WV+ +SP LL + Sbjct: 180 PGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEP 239 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L S+ K+YN+T A I LR+ +QRG+VV+ S ERIKEN Q+F+F L+ E+MK ++ L Sbjct: 240 VLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 N+N+R++ +++ HP +PF DEY Sbjct: 300 NRNMRYIPAAIFKGHPNWPFLDEY 323 >1AFS-A nrPDB Length = 323 Score = 379 bits (973), Expect = e-106, Method: Compositional matrix adjust. Identities = 175/323 (54%), Positives = 232/323 (71%), Gaps = 1/323 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 + + S R+ L+DGN IP++G GT + P+ K + K+AID G+RH D AY+Y+ E Sbjct: 1 MDSISLRVALNDGNFIPVLGFGT-TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEE 59 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 EVG+AIR KI +G V+REDIFY KLW+T H PE+VR LE+TL+ QLDYVDLYII P Sbjct: 60 EVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFP 119 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 MA +PGD +PRDE+GK L+ ++C TWEAME CKDAGL KS+GVSNFN RQLE ILNK Sbjct: 120 MALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNK 179 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECH Y Q K+L +C+ DI++ +Y LG+SR+ WV+ SP LL D Sbjct: 180 PGLKYKPVCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDP 239 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L ++ K+Y +T A + LR+ +QRGVV + +SFN +RIKE Q+F+F L E+MK ++ L Sbjct: 240 VLCAIAKKYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGL 299 Query: 303 NKNVRFVELLMWRDHPEYPFHDE 325 N+N R+ + DHP +PF DE Sbjct: 300 NRNFRYNNAKYFDDHPNHPFTDE 322 >5UXF-A nrPDB Length = 342 Score = 350 bits (899), Expect = 4e-97, Method: Compositional matrix adjust. Identities = 168/324 (51%), Positives = 221/324 (68%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +S+ H + L+DG+ IP +G GTY +PK PK + +A+D GYRH+D AY YQ E Sbjct: 20 MSSKQHCVKLNDGHLIPALGFGTY-KPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEE 78 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 E+G+AI+ IA G V+RED+F KLW T PE+V+P LE++L+ LQLDYVDLYI+ P Sbjct: 79 EIGQAIQSAIAAGVVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYP 138 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 + K GD +P +E GK L + C TWE +E CKDAGLVKS+GVSNFN RQLE ILNK Sbjct: 139 VPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNK 198 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECH Y Q KLL +C+ DIV+ AY LGT R WV+ +SP LL D Sbjct: 199 PGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDP 258 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L + K+ ++ A I LR+ IQRG+V + +SF ++EN Q+F F L+ E+MK ++ L Sbjct: 259 VLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGL 318 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 NKN R++ DHPEYPF +EY Sbjct: 319 NKNFRYLPAEFLVDHPEYPFVEEY 342 >1ZUA-X nrPDB Length = 317 Score = 331 bits (849), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 161/317 (50%), Positives = 214/317 (67%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ +P G +VKVAID GYRHID AY+YQNEHEVGEAI+ Sbjct: 6 VELSTKAKMPIVGLGTWK----SPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ 61 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E V+RED+F KLW T +VR E+TL+ L+L Y+D+Y+I P FK GD Sbjct: 62 EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 121 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 +++P+D+ G + K+ WEAME D GLVK+LGVSNF+ Q+E +LNKPGLK+KP Sbjct: 122 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 181 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + + Sbjct: 182 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP-WAKPEDPSLLEDPKIKEIAA 240 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KTAAQ+++RF+IQR V+VIPKS RI EN Q+FDF L++EEM I + N+N R Sbjct: 241 KHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRAC 300 Query: 310 ELLMWRDHPEYPFHDEY 326 +L +YPF+ EY Sbjct: 301 NVLQSSHLEDYPFNAEY 317 >3RX4-A nrPDB Length = 336 Score = 315 bits (808), Expect = 1e-86, Method: Compositional matrix adjust. Identities = 160/323 (49%), Positives = 223/323 (69%), Gaps = 5/323 (1%) Query: 4 SAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63 S + R+ L++G +PI+GLGT+ +P G +VKVAID GYRHID A++YQNE+E Sbjct: 19 SHMASRLLLNNGAKMPILGLGTWK----SPPGQVTEAVKVAIDVGYRHIDCAHVYQNENE 74 Query: 64 VGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123 VG AI+EK+ E V+RE++F KLW T H +V+ ++TL L+LDY+DLY+I P Sbjct: 75 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 134 Query: 124 AFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKP 183 FKPG E +P DE+G + +N+ TW AME D GLVK++G+SNFN Q+E+ILNKP Sbjct: 135 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 194 Query: 184 GLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDAL 243 GLK+KP NQ+ECHPY TQ KL+++CQ IV+TAYSPLG+ P W P LL+D Sbjct: 195 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP-WAKPEDPSLLEDPR 253 Query: 244 LNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 + ++ ++NKT AQ+++RF +QR +VVIPKS ERI ENF++FDF L+ ++M + + N Sbjct: 254 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 313 Query: 304 KNVRFVELLMWRDHPEYPFHDEY 326 +N R LL H +YPFH+E+ Sbjct: 314 RNWRVCALLSCTSHKDYPFHEEF 336 >1C9W-A nrPDB Length = 315 Score = 306 bits (784), Expect = 8e-84, Method: Compositional matrix adjust. Identities = 162/317 (51%), Positives = 209/317 (65%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ +P G +VKVAID GYRHID AY Y NEHEVGEAI+ Sbjct: 4 VELSTKAKMPIVGLGTWQ----SPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQ 59 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E VRRED+F KLW T ++++ ++TL L+LDY+DLY+I P +PG Sbjct: 60 EKIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E++P+D+ G L K WE ME D GLVK+LGVSNFN Q+E ILNKPGLKHKP Sbjct: 120 ELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKP 179 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + + Sbjct: 180 VTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRP-WAKPEDPSLLEDPKIKEIAA 238 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT+AQ+++RF+IQR VVVIPKS RI ENFQ+FDF L+++EM I N+N R Sbjct: 239 KHKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRAC 298 Query: 310 ELLMWRDHPEYPFHDEY 326 L + EYP+ EY Sbjct: 299 LLPETVNMEEYPYDAEY 315 >1DLA-A nrPDB Length = 314 Score = 302 bits (774), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 159/320 (49%), Positives = 217/320 (67%), Gaps = 6/320 (1%) Query: 7 SHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGE 66 SH + L G +PI+GLGT+ +P G +VKVAID GYRHID A++YQNE+EVG Sbjct: 1 SHLV-LYTGAKMPILGLGTWK----SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGL 55 Query: 67 AIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK 126 ++EK+ V+RED+F KLW T+H +V+ + TLR L+LDY+DLY+I P FK Sbjct: 56 GLQEKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFK 115 Query: 127 PGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLK 186 PG + +P D +G + +S+ TWEAME D GLVK++GVSNFN Q+E ILNKPGLK Sbjct: 116 PGKDPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLK 175 Query: 187 HKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNS 246 +KP NQ+E HPY TQ KL+++C+ IV+TAYSPLG+ P W P LL+D + + Sbjct: 176 YKPAVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRP-WAKPEDPSLLEDPRIKA 234 Query: 247 LGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNV 306 + +YNKT AQ+++RF +QR ++VIPKS ERI ENFQ+FDF L+ E+M + + N+N Sbjct: 235 IAAKYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNW 294 Query: 307 RFVELLMWRDHPEYPFHDEY 326 R L+ H +YPFH+EY Sbjct: 295 RVCALMSCASHKDYPFHEEY 314 >3O3R-A nrPDB Length = 316 Score = 301 bits (770), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 155/317 (48%), Positives = 206/317 (64%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L +P++GLGT+ +P G +VK AID GYRH D AY+YQNE EVGEAI+ Sbjct: 5 VKLRTKAKMPLVGLGTWK----SPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQ 60 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E VRRED+F KLW+T +++ ++TL L+LDY+DLY+I P + G Sbjct: 61 EKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGK 120 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E P+D GK L KS WE ME D GLVK+LGVSNFN Q+E +LNKPGLKHKP Sbjct: 121 EFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 180 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I + AYSPLG+ P + P +L+ + + Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRP-YAKPEDPVVLEIPKIKEIAA 239 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT AQ+++RF++QR V VIPKS L IKEN Q+FDF L+EE+M I +LN+N R Sbjct: 240 KHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRAC 299 Query: 310 ELLMWRDHPEYPFHDEY 326 L + D ++PFH+EY Sbjct: 300 GLFVTSDEEDFPFHEEY 316 >1FRB-A nrPDB Length = 315 Score = 296 bits (758), Expect = 8e-81, Method: Compositional matrix adjust. Identities = 158/317 (49%), Positives = 210/317 (66%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ P + K A VK AID GYRHID AY Y NE+EVGEAI+ Sbjct: 4 VELSTKAKMPIVGLGTWKSPPNQVKEA----VKAAIDAGYRHIDCAYAYCNENEVGEAIQ 59 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E V+RED+F KLW T ++++ ++TL L+LDY+DLY+I P +PG Sbjct: 60 EKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E++P+D+ G+ L K+ WE ME D GLVK+LGVSNFN Q+E +LNKPGLKHKP Sbjct: 120 ELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 179 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P P LL+D + + Sbjct: 180 VTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPS-AKPEDPSLLEDPKIKEIAA 238 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT+AQ+++RF+IQR VVVIPKS RI+EN Q+FDF L++EEM I + N+N R Sbjct: 239 KHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRAC 298 Query: 310 ELLMWRDHPEYPFHDEY 326 L + EYP+ EY Sbjct: 299 LLPETVNMEEYPYDAEY 315 >1HQT-A nrPDB Length = 326 Score = 278 bits (712), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 144/331 (43%), Positives = 215/331 (64%), Gaps = 17/331 (5%) Query: 6 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65 A+ + L G +P+IGLGT+ KS P G ++K A+ GYRHID A I+ NE E+G Sbjct: 3 AASCVLLHTGQKMPLIGLGTW---KSEP-GQVKAAIKYALTVGYRHIDCAAIFGNELEIG 58 Query: 66 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 59 EALQETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 118 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNF+ RQ++ +L+ Sbjct: 119 FERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVAS 178 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 + +P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + + P LL++ ++ Sbjct: 179 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPNEPVLLEEPVV 235 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 +L ++YN++ AQI+LR+ +QR V+ IPKS RI +N Q+FDF+ + EEMK ++ALNK Sbjct: 236 QALAEKYNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNK 295 Query: 305 NVRFVELLMWRD---------HPEYPFHDEY 326 N+RF+ ++ D HP YPF+D Y Sbjct: 296 NLRFIVPMLTVDGKRVPRDAGHPLYPFNDPY 326 >2ALR-A nrPDB Length = 324 Score = 274 bits (701), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 145/331 (43%), Positives = 211/331 (63%), Gaps = 17/331 (5%) Query: 6 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65 A+ + L G +P+IGLGT+ KS P G +VK A+ GYRHID A IY NE E+G Sbjct: 1 AASCVLLHTGQKMPLIGLGTW---KSEP-GQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 56 Query: 66 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 57 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 116 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNFN RQ++ IL+ Sbjct: 117 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 176 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 + +P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + P LL++ ++ Sbjct: 177 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVV 233 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 +L ++Y ++ AQI+LR+ +QR V+ IPKS RI +N ++FDF+ + EEMK + ALNK Sbjct: 234 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 293 Query: 305 NVRFVELLMWRD---------HPEYPFHDEY 326 N R++ ++ D HP YPF+D Y Sbjct: 294 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 324 >4GAC-A nrPDB Length = 324 Score = 273 bits (697), Expect = 9e-74, Method: Compositional matrix adjust. Identities = 141/325 (43%), Positives = 208/325 (64%), Gaps = 17/325 (5%) Query: 12 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREK 71 L G +P+IGLGT+ KS P G ++K A+ GYRHID A +Y NE E+GEA++E Sbjct: 7 LHTGQKMPLIGLGTW---KSEP-GQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKES 62 Query: 72 IAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDE 130 + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P AF+ GD Sbjct: 63 VGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 122 Query: 131 IYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPV 190 +P++ +G Y ++ TW+A+E GLVK+LG+SNFN RQ++ +L+ + +P Sbjct: 123 PFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV--RPA 180 Query: 191 SNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKR 250 QVECHPY Q +L+ C + +TAYSPLG+S + W + P LL++ ++ +L ++ Sbjct: 181 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVLALAEK 239 Query: 251 YNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVE 310 + ++ AQI+LR+ +QR V+ IPKS N RI +N Q+FDF+ + EEMK ++ALNKN R++ Sbjct: 240 HGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV 299 Query: 311 LLMWRD---------HPEYPFHDEY 326 ++ D HP YPF+D Y Sbjct: 300 PMITVDGKRVPRDAGHPLYPFNDPY 324 >4HBK-A nrPDB Length = 344 Score = 259 bits (661), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 133/318 (41%), Positives = 202/318 (63%), Gaps = 12/318 (3%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + +++G SIP+IGLGT++ +P G +VK A++ GYRH+D AY+Y+NE E+GEA+ Sbjct: 38 LKMNNGRSIPVIGLGTWN----SPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALE 93 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 + +++REDIF KLW T PE VR E TL+ L+L+Y+DLY+I P+ K G Sbjct: 94 NALNSLRLKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGG 153 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 +++P D NG+ TW+ ME D GLVKS+G+SNFN+RQ++ IL + KP Sbjct: 154 DLFPTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEH--CRIKP 211 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGT-SRNPIWVNVSSPPLLKDALLNSLG 248 + Q+E H F KL+++ Q + +TAY+PLG+ + +P VN+ + P + + + Sbjct: 212 ANLQIEIHANFPNIKLVEYAQSVGLTVTAYAPLGSPAHSPGKVNLLTKPCVLE-----IA 266 Query: 249 KRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 R+ KT AQ++LR+ +QR ++V+PKS +RI+ENFQ+FDF L+ EEM ++ + N R Sbjct: 267 HRHKKTPAQVLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQ 326 Query: 309 VELLMWRDHPEYPFHDEY 326 LL H EYPF +EY Sbjct: 327 FTLLQMSGHQEYPFKEEY 344 >3WCZ-A nrPDB Length = 308 Score = 237 bits (604), Expect = 6e-63, Method: Compositional matrix adjust. Identities = 130/316 (41%), Positives = 184/316 (58%), Gaps = 20/316 (6%) Query: 10 IPLSDGNSIPIIGLGTY--SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 I L+DGN+IPI+ LGT + +S +V AI+ GYRHID A +YQ+E +VG+ Sbjct: 8 IQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEEQVGQG 67 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 I E IA G V RE++F KLW H + V P L+ +L+ L LDY+DLY+I P+A KP Sbjct: 68 IAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHFPIATKP 127 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 D +N +L TW+ M+ + GL +S+GVSNFN Q+ +++ + Sbjct: 128 DDS----PDNIDYL-------ETWQGMQDARQLGLARSIGVSNFNATQITRLVSNSYI-- 174 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLG--TSRNPIWVNVSSPPLLKDALLN 245 +PV NQ+E +P TQ L+ CQ I + AYSP G SR + PP D L Sbjct: 175 RPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTG---APPPRSDDPTLT 231 Query: 246 SLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKN 305 +L +Y K+ QI+LR+ I RG++ IPKS N +RI +N +FDF LT EE+ I NKN Sbjct: 232 ALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNKN 291 Query: 306 VRFVELLMWRDHPEYP 321 R +++ W+D+P YP Sbjct: 292 HRVIDISDWKDYPNYP 307 >5JH1-A nrPDB Length = 309 Score = 212 bits (540), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 117/283 (41%), Positives = 171/283 (60%), Gaps = 16/283 (5%) Query: 12 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREK 71 L+ G IP +GLG++ +S P G +V A+ GYRHID A +Y NE E+G A+++ Sbjct: 6 LNTGAKIPSVGLGSW---QSDP-GVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKKL 61 Query: 72 IAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEI 131 EG V+RED+F KLW +H PE V L +L LQL+Y+DLY+I P K G Sbjct: 62 FEEGVVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGTNT 121 Query: 132 YPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVS 191 P + + + ATW AME DAG +++GVSNF+ ++L +L + P Sbjct: 122 SPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVA--RVPPAV 173 Query: 192 NQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRY 251 +QVECHP + Q KL FCQ + +TAYSPLG S W+N + +LK+ ++ S+ ++ Sbjct: 174 DQVECHPGWQQTKLHSFCQSTGVHLTAYSPLG-SPGTTWMNGN---VLKEPIIISIAEKL 229 Query: 252 NKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEE 294 KT+AQ+ LR+NIQ G V+PKS N ERIK+N ++D+S+ ++ Sbjct: 230 GKTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDD 272 >3H7R-A nrPDB Length = 331 Score = 211 bits (536), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 111/284 (39%), Positives = 177/284 (62%), Gaps = 21/284 (7%) Query: 12 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREK 71 L+ G +P +GLGTY+ AT+++ AI GYRHID A IY NE E+G +++ Sbjct: 30 LNTGAKLPCVGLGTYA--------MVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKL 81 Query: 72 IAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEI 131 I +G V+RE++F KLW+ +H+PE V LE+TL+ LQ+DYVDLY+I P + K + + Sbjct: 82 IGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKK-ESL 140 Query: 132 YPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVS 191 P E + K ++ +TW+AMEA D+G +++GVSNF+ ++L +LN + P Sbjct: 141 MPTPE----MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVA--RVTPAV 194 Query: 192 NQVECHPYFTQPKLLKFCQQHDIVITAYSPLGT-SRNPIWVNVSSPPLLKDALLNSLGKR 250 NQVECHP + Q L + C+ + ++ YSPLG+ S+ + + V L++ ++ + ++ Sbjct: 195 NQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKV-----LQNPIVTEVAEK 249 Query: 251 YNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEE 294 KT AQ+ LR+ +Q G V+PKS + R+KEN +FD+S+ E+ Sbjct: 250 LGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPED 293 >1QWK-A nrPDB Length = 317 Score = 211 bits (536), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 127/335 (37%), Positives = 188/335 (56%), Gaps = 32/335 (9%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +S+A+ I LS+G +P+IGLGT+ +S+P T+VK A+ GYR ID A +YQNE Sbjct: 1 MSSATASIKLSNGVEMPVIGLGTW---QSSP-AEVITAVKTAVKAGYRLIDTASVYQNEE 56 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 +G AI+E + EG V+RE++F K W P + L +L+ LQL+YVDLY+ +P Sbjct: 57 AIGTAIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMP 116 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 AF D++ + S + W +A AGL K++GVSN+N Q+ L Sbjct: 117 AAFN--DDMSE--------HIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRAL-- 164 Query: 183 PGLKHKPVSN-QVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVS------- 234 L PV N QVE H YF Q + FC++H+I +T+Y+ LG+ P VN + Sbjct: 165 -ALGLTPVHNSQVELHLYFPQHDHVDFCKKHNISVTSYATLGS---PGRVNFTLPTGQKL 220 Query: 235 ----SPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFS 290 +P L+D + +L ++ +KT AQ++LR+ + RG ++PKS RIKENF++FDFS Sbjct: 221 DWAPAPSDLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFS 280 Query: 291 LTEEEMKDIEALNKNVRFVELLMWRDHPEYPFHDE 325 LTEE++ +E + R HPE F E Sbjct: 281 LTEEDIAKLEESKNSQRLFLQDFMTGHPEDAFAAE 315 >1K8C-A nrPDB Length = 322 Score = 208 bits (530), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 126/328 (38%), Positives = 185/328 (56%), Gaps = 17/328 (5%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +SA+ I LS G+ +P IG G + +T V AI GYR DGA Y NE Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCWKLANAT----AGEQVYQAIKAGYRLFDGAEDYGNEK 56 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 EVG+ ++ I EG V+RE+IF KLW H P+ V L +TL L++DYVDL++I P Sbjct: 57 EVGDGVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFP 116 Query: 123 MAFK--PGDEIYPR----DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQL 176 +AFK P +E YP + ++Y + TW+A+E AG +KS+GVSNF L Sbjct: 117 IAFKFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALL 176 Query: 177 ELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVN---- 232 +L G KP QVE HPY QPKL++F Q+ + ITAYS G ++ + +N Sbjct: 177 LDLLR--GATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFG-PQSFVEMNQGRA 233 Query: 233 VSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLT 292 +++P L + ++ +YNKT A+++LR+ QRG+ VIPKS ER+ +N F LT Sbjct: 234 LNTPTLFAHDTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLT 293 Query: 293 EEEMKDIEALNKNVRFVELLMWRDHPEY 320 +E+ ++I L+ +RF + W + P + Sbjct: 294 KEDFEEIAKLDIGLRFNDPWDWDNIPIF 321 >3H7U-A nrPDB Length = 335 Score = 206 bits (524), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 115/282 (40%), Positives = 172/282 (60%), Gaps = 15/282 (5%) Query: 12 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREK 71 L+ G P +GLGT+ +++P G +V A+ GYRHID A IY NE E+G +++ Sbjct: 30 LNTGAKFPSVGLGTW---QASP-GLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLKKL 85 Query: 72 IAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEI 131 + V+RED+F KLW T+H P+ V L RTL+ LQL+YVDLY+I P K G + Sbjct: 86 FEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKGS-V 144 Query: 132 YPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVS 191 + EN ++ +TW+AMEA D+G +++GVSNF+ ++L +L + P Sbjct: 145 GIKPEN----LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELA--RVPPAV 198 Query: 192 NQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRY 251 NQVECHP + Q KL +FC+ + ++AYSPLG S W+ +LK+ +LN + ++ Sbjct: 199 NQVECHPSWRQTKLQEFCKSKGVHLSAYSPLG-SPGTTWLKSD---VLKNPILNMVAEKL 254 Query: 252 NKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTE 293 K+ AQ+ LR+ +Q G V+PKS N RIKENF +FD+S+ + Sbjct: 255 GKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPD 296 >4GIE-A nrPDB Length = 290 Score = 204 bits (519), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 113/299 (37%), Positives = 168/299 (56%), Gaps = 37/299 (12%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L + +P +GLG + ++ A +V+ AI+ GYRHID AYIY NE VG+ IR Sbjct: 16 VTLHNSVRMPQLGLGVW---RAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIR 72 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 E V RE+++ K+W ++ E ER+ +L L+Y+DLY+I P Sbjct: 73 ES----GVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP------- 121 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 K TW+A+E + V+++GVSNF L + K +P Sbjct: 122 -------------GKKKFVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKS--CKIRP 166 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 + NQVE HP F Q L +FC+QH+I ITA+SPLG+ +LK+ +L + K Sbjct: 167 MVNQVELHPLFQQRTLREFCKQHNIAITAWSPLGSG--------EEAGILKNHVLGEIAK 218 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 ++NK+ AQ+V+R++IQ G+V IPKS N RI+ENF ++DF LTEEEM+ I+ LN++ R Sbjct: 219 KHNKSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELNEDKRI 277 >5Z6T-A nrPDB Length = 343 Score = 202 bits (515), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 119/321 (37%), Positives = 179/321 (55%), Gaps = 17/321 (5%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 I L+ G +P +G G + T C+ + AI TGYR DGA Y NE VG ++ Sbjct: 29 IKLNSGYDMPAVGFGCWKVDVDT----CSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVK 84 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK--P 127 + I EG V+RED+F KLW H P+ V L RTL LQ+DYVDL++I P+ FK P Sbjct: 85 KAIDEGIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVP 144 Query: 128 GDEIYPR----DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKP 183 +E YP + + Y + TW+A+E AG ++S+GVSNF L +L Sbjct: 145 LEEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLR-- 202 Query: 184 GLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVN----VSSPPLL 239 G KP QVE HPY QP+L++F Q I +TAYS G ++ + +N +++ PL Sbjct: 203 GATIKPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFG-PQSFVELNQGRALNTSPLF 261 Query: 240 KDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDI 299 ++ + ++ ++ K+ AQ++LR++ QRG+ +IPKS + R+ EN + F L E++ DI Sbjct: 262 ENETIKAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADI 321 Query: 300 EALNKNVRFVELLMWRDHPEY 320 L+ N+RF + W P + Sbjct: 322 AKLDINLRFNDPWDWDKIPIF 342 >5ZCM-A nrPDB Length = 341 Score = 199 bits (506), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 111/308 (36%), Positives = 174/308 (56%), Gaps = 15/308 (4%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 I L+ G +P++G G + +T CA +V AI GYR D A Y N E+GE I Sbjct: 24 IKLNSGYEMPLVGFGCWKVDNAT----CADTVYNAIKVGYRLFDAAMDYGNCKEIGEGIN 79 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK--P 127 + EG V R+++F KLW + H P+ V L++ L ++LDY+DL++I P+AFK P Sbjct: 80 RALDEGLVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVP 139 Query: 128 GDEIYPR----DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKP 183 +E YP + + Y L TW+AME G KS+G+SNF+ + +L Sbjct: 140 FEEKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLR-- 197 Query: 184 GLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVN---VSSPPLLK 240 G + KP Q+E HPY QP+L+++ Q I ITAYS G + + +P L + Sbjct: 198 GAEIKPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLFE 257 Query: 241 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 300 + S+ +Y KT AQ++LR+ QR + +IPKS N +R+ +N ++ DF+L++E+ +I Sbjct: 258 HKTITSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEIS 317 Query: 301 ALNKNVRF 308 L++++RF Sbjct: 318 KLDQDLRF 325 >2BGQ-A nrPDB Length = 344 Score = 193 bits (491), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 118/313 (37%), Positives = 173/313 (55%), Gaps = 25/313 (7%) Query: 12 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAI-DTGYRHIDGAYIYQNEHEVGEAIRE 70 L G+++P +GLGT+ T A SV+ AI + GYRH+D A Y E EVG+ ++ Sbjct: 42 LKSGHAMPAVGLGTWRAGSDT-----AHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKA 96 Query: 71 KIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDE 130 + G + R+D+F K+W TN PE VRP LE TL+ LQLDY+DLY I P K G Sbjct: 97 AMEAG-IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAH 155 Query: 131 IYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPV 190 + P E G+ L + ++ W+ ME GLVK +GV N+ +L +L K P Sbjct: 156 MPP--EAGEVL--EFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSA--KIPPA 209 Query: 191 SNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKR 250 Q+E HP + K+ + C++H I ITAYSPLG+S L D ++ + + Sbjct: 210 VCQMEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEK---------NLAHDPVVEKVANK 260 Query: 251 YNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV- 309 NKT Q+++++ +QRG VIPKS ERIKEN Q+F + + EE+ K + ++ R + Sbjct: 261 LNKTPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLT 320 Query: 310 --ELLMWRDHPEY 320 EL + + H Y Sbjct: 321 GEELFVNKTHGPY 333 >4F40-A nrPDB Length = 288 Score = 190 bits (483), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 117/299 (39%), Positives = 163/299 (54%), Gaps = 32/299 (10%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS+G +P GLG + P +VK A+ GYRHID A IY+NE VG +R Sbjct: 13 VTLSNGVKMPQFGLGVWQSPAGE---VTENAVKWALCAGYRHIDTAAIYKNEESVGAGLR 69 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 A G V RED+F KLW T E E + + L +DY+DLY+I P G Sbjct: 70 ---ASG-VPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWPR----GK 121 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 +I + E K+L +W A E V+++GVSNF+ LE +L + P Sbjct: 122 DILSK-EGKKYL-------DSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVT--P 171 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 + NQVE HP Q L FC I + A+SPLG + LL + +L+++G Sbjct: 172 MVNQVELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK-----------LLSNPILSAIGA 220 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 +YNKTAAQ++LR+NIQ+ ++ IPKS + ERI+EN IFDF L E++ I+ALN N R+ Sbjct: 221 KYNKTAAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >1VBJ-A nrPDB Length = 281 Score = 190 bits (483), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 111/307 (36%), Positives = 162/307 (52%), Gaps = 40/307 (13%) Query: 2 DLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNE 61 + A + + LS+G +P++G G + K T+ AI +GYRHID A IY+NE Sbjct: 4 EFMALTQSLKLSNGVMMPVLGFGMW---KLQDGNEAETATMWAIKSGYRHIDTAAIYKNE 60 Query: 62 HEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEV 121 G AI A V RE++F KLW ++ E E++++ L L+YVDLY+I Sbjct: 61 ESAGRAI----ASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHW 116 Query: 122 PMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILN 181 P K TW+A E V+++GVSNF+ +E +L Sbjct: 117 P--------------------GKDKFIDTWKAFEKLYADKKVRAIGVSNFHEHHIEELLK 156 Query: 182 KPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKD 241 K P+ NQ+E HP Q L ++C+ +I +TA+SPLG L++D Sbjct: 157 H--CKVAPMVNQIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGH-----------LVED 203 Query: 242 ALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEA 301 A L ++G +Y KTAAQ++LR+ IQ GV+ IPKS N RIKEN IFDF LT E+++ I+ Sbjct: 204 ARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDG 263 Query: 302 LNKNVRF 308 +N R+ Sbjct: 264 MNAGHRY 270 >3KRB-A nrPDB Length = 334 Score = 187 bits (475), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 112/312 (35%), Positives = 174/312 (55%), Gaps = 23/312 (7%) Query: 19 PIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIRE--KIAEGK 76 P +G GT+ P A T+V+ A+ TGYRHID AY+YQNE +G A + K A Sbjct: 26 PRLGFGTWQAPPE----AVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSG 81 Query: 77 VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD--EIYPR 134 ++RED++ KLW NH PE+VR ++T+ LQ+DY+DL+++ P+AF D +++P+ Sbjct: 82 IKREDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPK 141 Query: 135 DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQV 194 D G+ + K L TW AME + GLVK +GVSN+ L +LN K KP+ NQ+ Sbjct: 142 DAEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNY--AKIKPLVNQI 199 Query: 195 ECHPYFTQPKLLKFCQQHDIVITAYSPLGTS----RNPIWVNVSSPPLLKDALLNSLGKR 250 E HP+ +KFC + I +TAYSP+G S R+P +L+ L ++ Sbjct: 200 EIHPWHPNDATVKFCLDNGIGVTAYSPMGGSYADPRDP--SGTQKNVILECKTLKAIADA 257 Query: 251 YNKTAAQIVLRFNIQRGVV----VIPKSFNLERIKENFQIFDFSLTEEEMKDIEA--LNK 304 + + L +++++ VIPKS RI+ NF+ + L++++M I LNK Sbjct: 258 KGTSPHCVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNK 317 Query: 305 NVRFVE-LLMWR 315 +RF + + W+ Sbjct: 318 RIRFCDPAIFWK 329 >1VP5-A nrPDB Length = 298 Score = 181 bits (460), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 102/298 (34%), Positives = 164/298 (55%), Gaps = 38/298 (12%) Query: 9 RIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAI 68 ++ L++G +PI+G G + P + ++KV GYR ID A Y NE VG AI Sbjct: 17 KVTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKV----GYRLIDTAASYMNEEGVGRAI 72 Query: 69 REKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPG 128 + I EG VRRE++F KLW ++ E + E++L+ LQL+Y+DLY+I P Sbjct: 73 KRAIDEGIVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFG---- 128 Query: 129 DEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFN-RRQLELILNKPGLKH 187 ++ W+AME GLV+++GVSNF R ++L+++ + Sbjct: 129 -----------------DVHCAWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIV-- 169 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 P NQ+E HP++ + + ++F + ++I A+ P R I+ N +L S+ Sbjct: 170 -PAVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRKNIFQN---------GVLRSI 219 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKN 305 ++Y KT AQ++LR+ Q+G+V IPK+ ER+KEN IFDF LT+E+M+ I L++ Sbjct: 220 AEKYGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEG 277 >4IJC-A nrPDB Length = 344 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 109/313 (34%), Positives = 177/313 (56%), Gaps = 31/313 (9%) Query: 12 LSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREK 71 L++G IP +GLGT + + + A VK AI GYRHID A+ Y+ E VGEAI+E Sbjct: 27 LNNGVRIPALGLGTANPHEKLAETKQA--VKAAIKAGYRHIDTAWAYETEPFVGEAIKEL 84 Query: 72 IAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK----- 126 + +G ++RED+F K+W + + V +L +L+ L L+YVDL + P+ F+ Sbjct: 85 LEDGSIKREDLFITTKVWPV--LWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDP 142 Query: 127 ---PGDEIYPRDENGKWLYHK-SNLCATWEAMEAC---KDAGLVKSLGVSNFNRRQLELI 179 G P D++GK +Y + T++ +E + V+++GVSNF+ LE + Sbjct: 143 KGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERL 202 Query: 180 LNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLL 239 + + + KP NQVE HP+ Q +L KFC HDI++TAYSPLG+ P L Sbjct: 203 IKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGS---------HGAPNL 251 Query: 240 KDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDI 299 K L+ L ++YN T +++ ++I++G +VIP+S N RI + + SLT++E++++ Sbjct: 252 KIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQEL 309 Query: 300 EALNKN--VRFVE 310 + VRF++ Sbjct: 310 NDFGEKYPVRFID 322 >1MZR-A nrPDB Length = 296 Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 99/299 (33%), Positives = 154/299 (51%), Gaps = 39/299 (13%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 I L DGN +P +GLG + T+++ A++ GYR ID A Y+NE VG+A++ Sbjct: 28 IKLQDGNVMPQLGLGVWQASNEE----VITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 83 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 V RE++F KLW +H + R L +L+ LQLDY+DLY++ P+ P Sbjct: 84 N----ASVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPV---PAI 134 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 + Y W+ M + GL+KS+GV NF L+ ++++ G+ P Sbjct: 135 DHY---------------VEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--P 177 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQ+E HP Q +L + H I ++SPL + ++ L Sbjct: 178 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGV---------FDQKVIRDLAD 228 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 +Y KT AQIV+R+++ G+VVIPKS RI ENF ++DF L ++E+ +I L++ R Sbjct: 229 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 287 >3D3F-A nrPDB Length = 275 Score = 162 bits (409), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 111/298 (37%), Positives = 156/298 (52%), Gaps = 40/298 (13%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L +G +P GLG + K SVK AI GYR ID A IY+NE VG I+ Sbjct: 8 VKLHNGVEMPWFGLGVF---KVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIK 64 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 E V RE++F K+W + E E++L LQLDY+DLY+I P K D Sbjct: 65 E----SGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYKD 120 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 TW A+E G ++++GVSNF LE +L +K P Sbjct: 121 --------------------TWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIK--P 158 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 + NQVE HP TQ +L +C+ I + A+SPL + LL + +L + + Sbjct: 159 MVNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ-----------LLDNEVLTQIAE 207 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVR 307 ++NK+ AQ++LR+++Q GVV IPKS RI EN IFDF L++E+M I+ALNK+ R Sbjct: 208 KHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDER 265 >4MHB-A nrPDB Length = 297 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 96/294 (32%), Positives = 152/294 (51%), Gaps = 39/294 (13%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L++G ++P++G G + + T C +V AI+TGYR ID A YQNE +VG A++ Sbjct: 18 VKLNNGIAMPLLGFGVF---QMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALK 74 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 + R+++F KLW + E + ER+L LQLDYVDLY+I P Sbjct: 75 LS----GIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYG----- 125 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 ++ W AME AG ++++GVSNF+ +L ++ K P Sbjct: 126 ----------------DVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFN--KIIP 167 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 NQ+E +P+ Q + + Q I A++P RN L ++ +L ++G+ Sbjct: 168 AVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNG---------LFQNPVLTAIGE 218 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 +Y K+ Q+VLR+ QRG+V + KS R++EN I DF L+ E+M I AL+ Sbjct: 219 KYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALD 272 >1A80-A nrPDB Length = 277 Score = 157 bits (398), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 100/294 (34%), Positives = 149/294 (50%), Gaps = 37/294 (12%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 I L+DGNSIP +G G + P + + A V+ A++ GYRHID A IY NE E + Sbjct: 5 IVLNDGNSIPQLGYGVFKVPPADTQRA----VEEALEVGYRHIDTAAIYGNE----EGVG 56 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 IA + R+D+F KLW H + + +L L LD VDLY++ P Sbjct: 57 AAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTPAA--- 113 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 N WE M + AGL +S+GVSN LE I+ G+ P Sbjct: 114 ---------------DNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVV--P 156 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 NQ+E HP + Q ++ + HD+ I ++ PLG + ++ + P+ + Sbjct: 157 AVNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYDLF---GAEPV------TAAAA 207 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 + KT AQ VLR+++Q+G VV PKS ER++EN +FDF LT+ E+ I+A++ Sbjct: 208 AHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >3UP8-A nrPDB Length = 298 Score = 156 bits (395), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 102/308 (33%), Positives = 162/308 (52%), Gaps = 60/308 (19%) Query: 13 SDGNSIPIIGLGTYSEPKSTPKGACATSVKV---AIDTGYRHIDGAYIYQNEHEVGEAIR 69 S+G +IP +G GT+ + + A +++ A+ G+RH+D A IY NE EVGEAI+ Sbjct: 29 SNGANIPALGFGTF-------RMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQ 81 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYII-----EVPMA 124 + + R D+F K+W N+ + +++ +LR L+ D+VDL ++ +VPMA Sbjct: 82 KS----GIPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPGSDVPMA 137 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 + G A+ ++AG V+ +G+SNFN Q+E Sbjct: 138 ERIG------------------------ALNEVRNAGKVRHIGISNFNTTQME---EAAR 170 Query: 185 LKHKPV-SNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDAL 243 L P+ +NQVE HPY Q K+L+ ++ + +T+Y + + P D L Sbjct: 171 LSDAPIATNQVEYHPYLDQTKVLQTARRLGMSLTSYYAMANGKVP-----------ADPL 219 Query: 244 LNSLGKRYNKTAAQIVLRFNIQR-GVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 L +G R+ KTAAQ+ LR+ +Q+ V+V+ K+ R+KENF IFDF+LT EEM + L Sbjct: 220 LTEIGGRHGKTAAQVALRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVREL 279 Query: 303 NK-NVRFV 309 + N R V Sbjct: 280 ARPNGRIV 287 >4OTK-A nrPDB Length = 318 Score = 147 bits (370), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 104/311 (33%), Positives = 147/311 (47%), Gaps = 47/311 (15%) Query: 4 SAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63 +AA+ I L+D +++P++GLG + A V A++ G R ID AY Y NE Sbjct: 43 AAAAPSITLNDEHTMPVLGLGVAELSDDETERA----VSAALEIGCRLIDTAYAYGNEAA 98 Query: 64 VGEAIREKIAEGKVRREDIFYCGKLWATNH----VPEMVRPTLERTLRVLQLDYVDLYII 119 VG AI A V RE++F KL + E R +L+R L LDYVDLY+I Sbjct: 99 VGRAI----AASGVAREELFVTTKLATPDQGFTRSQEACRASLDR----LGLDYVDLYLI 150 Query: 120 EVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI 179 +P GK++ W M + G +S+GVSNF +E + Sbjct: 151 H-----------WPAPPVGKYV-------DAWGGMIQSRGEGHARSIGVSNFTAENIENL 192 Query: 180 LNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLL 239 ++ + P NQ+E HP Q +L K QH +V +Y PL R LL Sbjct: 193 IDLTFVT--PAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR-----------LL 239 Query: 240 KDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDI 299 + + S+ Y KT AQ++LR+N+Q G V+ +S ERI NF +FDF L E M + Sbjct: 240 DNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDAL 299 Query: 300 EALNKNVRFVE 310 LN R E Sbjct: 300 GGLNDGTRVRE 310 >3WG6-A nrPDB Length = 307 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 97/315 (30%), Positives = 151/315 (47%), Gaps = 39/315 (12%) Query: 3 LSAASHRIPLSDGNSIPIIGLGT----YSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY 58 +S A LS+GN IP + GT + + ++++A+ +G+RHIDGA IY Sbjct: 4 MSLAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIY 63 Query: 59 QNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRP-------TLERTLRVLQL 111 E+G A++ + R+D+F K + NH + L+ L L L Sbjct: 64 GTNKEIGIALKNV----GLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGL 119 Query: 112 DYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNF 171 +YVDLY+I P + H +L W +E K+ GL +++GVSNF Sbjct: 120 EYVDLYLIHFPYISEKS--------------HGFDLVEAWRYLERAKNEGLARNIGVSNF 165 Query: 172 NRRQLELILNKPGLKHKPVSNQVECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTSRNPI 229 L+ IL+ PV NQ+E Y P ++++ QQ I+I AY PLG PI Sbjct: 166 TIENLKSILD-ANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLG----PI 220 Query: 230 WVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDF 289 P D +L+ L ++Y + QI+LR+ +QRG++ I + ERI + +IFDF Sbjct: 221 TQGRPGPL---DKVLSKLSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDF 277 Query: 290 SLTEEEMKDIEALNK 304 L +E+ I + K Sbjct: 278 ELDKEDEDQITKVGK 292 >4H8N-A nrPDB Length = 310 Score = 137 bits (344), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 143/267 (53%), Gaps = 31/267 (11%) Query: 40 SVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVRREDIFYCGKL---WAT-NHVP 95 ++ + + G+RHID A Y + EVGEA++ V REDI+ K W + Sbjct: 48 NILLGLKLGFRHIDTAEAYNTQKEVGEALKRT----DVPREDIWVTTKYSPGWGSIKAYS 103 Query: 96 EMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAME 155 + ++++ L L +DYVDL++I P + ++ H L WEA+ Sbjct: 104 KSPSDSIDKALAQLGVDYVDLFLIHSPF--------FTTEQT-----HGYTLEQAWEALV 150 Query: 156 ACKDAGLVKSLGVSNFNRRQLE-LILNKPGLKHKPVSNQVECHPYF-TQPK-LLKFCQQH 212 K AG V+ +G+SN LE L P ++ PV NQ+E HP+ Q K +++FCQ+H Sbjct: 151 EAKKAGKVREIGISNAAIPHLEKLFAASPSPEYYPVVNQIEFHPFLQNQSKNIVRFCQEH 210 Query: 213 DIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIP 272 I++ A+SPL P+ V + L + L L ++Y KT AQ++LR+ +QRG++ + Sbjct: 211 GILVEAFSPLA----PL-ARVETNALAET--LKRLAEKYKKTEAQVLLRYTLQRGILPVT 263 Query: 273 KSFNLERIKENFQIFDFSLTEEEMKDI 299 S R+KE+ +FDF LT+EE+ +I Sbjct: 264 TSSKESRLKESLNLFDFELTDEEVNEI 290 >1PYF-A nrPDB Length = 312 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 70/295 (23%), Positives = 127/295 (43%), Gaps = 60/295 (20%) Query: 41 VKVAIDTGYRHIDGAYIY---QNEHEVGEAIREKIAEGKVRREDIFYC--------GKLW 89 V+ AI G +D AYIY ++E +GE +RE RED+ G + Sbjct: 41 VREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE------FNREDVVIATKAAHRKQGNDF 94 Query: 90 ATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCA 149 ++ P+ ++ +++ +L+ L DY+DL+ I P DE P+DE Sbjct: 95 VFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP------DEHTPKDE------------- 135 Query: 150 TWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFC 209 A+ K AG ++S+GVSNF+ QL+ NK GL + + + + Sbjct: 136 AVNALNEMKKAGKIRSIGVSNFSLEQLKEA-NKDGLV-DVLQGEYNLLNREAEKTFFPYT 193 Query: 210 QQHDIVITAYSPL--GTSRNPIWVNVSSPP------------------LLKDALLNSLGK 249 ++H+I Y PL G + + P + K L + + Sbjct: 194 KEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAE 253 Query: 250 RYNKTAAQIVLRFNIQRGV--VVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 ++N IVL + + R ++IP + +++ +N + D +L++E++ I+ L Sbjct: 254 KHNVDIPHIVLAWYLARPEIDILIPGAKRADQLIDNIKTADVTLSQEDISFIDKL 308 >1PZ1-A nrPDB Length = 333 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/172 (28%), Positives = 81/172 (47%), Gaps = 39/172 (22%) Query: 21 IGLGTYSEPKS----TPKGACATSVKVAIDTGYRHIDGAYIY---QNEHEVGEAIREKIA 73 IGLGT++ + T + +++ A+D G ID A Y Q+E VG+AI+E + Sbjct: 16 IGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGKAIKEYM- 74 Query: 74 EGKVRREDIFYCGKL---WATNHV-----PEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125 +R+ + K W N + + +E +L+ LQ DY+DLY + P Sbjct: 75 ----KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQVHWP--- 127 Query: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLE 177 D + P +E T E M+ DAG ++++GVSNF+ Q++ Sbjct: 128 ---DPLVPIEE-------------TAEVMKELYDAGKIRAIGVSNFSIEQMD 163 >4R9O-A nrPDB Length = 301 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 70/276 (25%), Positives = 115/276 (41%), Gaps = 58/276 (21%) Query: 45 IDTGYRHIDGAYIY---QNEHEVGEAI------REKIAEGKVRREDIFYCG---KLWATN 92 +D G +D A IY Q E GEA+ REK+ + + CG A N Sbjct: 45 LDLGVTTVDHADIYGGYQCEAAFGEALTLAPHLREKL-------QIVTKCGIATTARAEN 97 Query: 93 HVPEMVRP------TLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSN 146 + + + E++L+ L DY+D+ +I P D++ Sbjct: 98 KLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDADDVA-------------- 143 Query: 147 LCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLL 206 EA + +G V+ GVSNF Q L+ ++ L +NQVE P QP LL Sbjct: 144 -----EAFQHLHQSGKVRHFGVSNFTPAQFTLLQSR--LPFTLATNQVEISPVH-QPLLL 195 Query: 207 KFC----QQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRF 262 QQ I A+S LG R ++ + + PL ++ L+ + + N ++ + V+ Sbjct: 196 DGTLDQLQQLRIRPMAWSCLGGGR--LFNDEAYQPLRQE--LSVIAQELNASSIEQVVYA 251 Query: 263 NIQR---GVVVIPKSFNLERIKENFQIFDFSLTEEE 295 I R + I S +ER++ + SLT ++ Sbjct: 252 WILRLPSQPLPIIGSGKIERVRAALEAETLSLTRQQ 287 >1LQA-A nrPDB Length = 346 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 78/350 (22%), Positives = 134/350 (38%), Gaps = 67/350 (19%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQ-------- 59 HRIP S + +GLGT + + + + A+ G ID A +Y Sbjct: 4 HRIPHSS-LEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQ 62 Query: 60 --NEHEVG-----EAIREKI-----AEGKVRRED--IFYCGKLWATNHVPEMVRPTLERT 105 E VG REK+ G R D I L N +R L + Sbjct: 63 GLTETYVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKN-----IREALHDS 117 Query: 106 LRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSN------LCATWEAMEACKD 159 L+ LQ DY+DLY + P P + GK Y ++ L T +A+ + Sbjct: 118 LKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQR 169 Query: 160 AGLVKSLGVSNFNR----RQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIV 215 AG ++ +GVSN R L L + + N + L + Q + Sbjct: 170 AGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVE 229 Query: 216 ITAYSPLG-TSRNPIWVNVSSPPLLKDALLN------------------SLGKRYNKTAA 256 + AYS LG + ++N + P ++ L + + +R+ A Sbjct: 230 LLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPA 289 Query: 257 QIVLRFNIQRGVV--VIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 Q+ L F ++ V + + ++++K N + L+E+ + +IEA+++ Sbjct: 290 QMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQ 339 >1OG6-A nrPDB Length = 298 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 81/201 (40%), Gaps = 45/201 (22%) Query: 45 IDTGYRHIDGAYIY---QNEHEVGEAIREKIA-EGKVRREDIFYCGKLWATNHVPEMVR- 99 +D G +D A IY Q E GEA+ K+A + R E + CG AT E V Sbjct: 42 LDLGVTTVDHADIYGGYQCEAAFGEAL--KLAPHLRERMEIVSKCGI--ATTAREENVIG 97 Query: 100 ----------PTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCA 149 + E++L L D++DL +I P DE+ Sbjct: 98 HYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDADEVA----------------- 140 Query: 150 TWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFC 209 +A + +G V+ GVSNF Q L+ ++ L +NQVE P QP LL Sbjct: 141 --DAFKHLHQSGKVRHFGVSNFTPAQFALLQSR--LPFTLATNQVEISPVH-QPLLLDGT 195 Query: 210 ----QQHDIVITAYSPLGTSR 226 QQ + A+S LG R Sbjct: 196 LDQLQQLRVRPMAWSCLGGGR 216 >2C91-A nrPDB Length = 338 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 49/187 (26%), Positives = 75/187 (40%), Gaps = 25/187 (13%) Query: 19 PIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIREKIAEGKVR 78 P LGT + A A SV+ ++ G+ +D A++Y + E I G Sbjct: 17 PATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQS------ENILGGLGL 70 Query: 79 REDIFYCGKLWATNH--------VPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDE 130 C AT P+ +R LE +L+ LQ VDL+ + P P +E Sbjct: 71 GLGSGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPDHSTPVEE 130 Query: 131 I----YPRDENGKWLYHKSNLCATWEAME---ACKDAGLVKSL---GVSNFNRRQLELIL 180 + + GK++ + A+WE E CK G + G+ N RQ+E L Sbjct: 131 TLCACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAEL 190 Query: 181 NKPGLKH 187 P L+H Sbjct: 191 -LPCLRH 196 >2BP1-A nrPDB Length = 360 Score = 34.7 bits (78), Expect = 0.060, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 65/155 (41%), Gaps = 13/155 (8%) Query: 45 IDTGYRHIDGAYIYQN-EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHV-PEMVRPTL 102 ++ G+ +D A++Y + + E G R I W + P+ VR L Sbjct: 65 LERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQL 124 Query: 103 ERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPR----DENGKWLYHKSNLCATWEAMEA-- 156 E +L+ LQ VDL+ + P P +E + GK++ + A+WE E Sbjct: 125 ETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICT 184 Query: 157 -CKDAGLVKSL---GVSNFNRRQLELILNKPGLKH 187 CK G + G+ N RQ+E L P L+H Sbjct: 185 LCKSNGWILPTVYQGMYNATTRQVETELF-PCLRH 218 >5E5H-A nrPDB Length = 514 Score = 34.7 bits (78), Expect = 0.061, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 53/105 (50%), Gaps = 10/105 (9%) Query: 229 IWVNVSSPPLLKDALLNSLGKRYN---KTAAQIVLRFNIQRG---VVVIPKSFNLERIKE 282 I+ NV+S ++ ++N +G + + I L + +G ++P + +++ I + Sbjct: 368 IYGNVNSTRVMGSKMMNGIGGSGDFARSSYLSIFLSPSTAKGGKISAIVPMAAHVDHIMQ 427 Query: 283 NFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEY-PFHDEY 326 + QIF +TE+ + D+ L+ R E++ HP+Y P +Y Sbjct: 428 DAQIF---VTEQGLADLRGLSPVQRAREIISKCAHPDYRPMLQDY 469 >4EHI-A nrPDB Length = 534 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 11/18 (61%), Positives = 15/18 (83%) Query: 49 YRHIDGAYIYQNEHEVGE 66 ++HIDG ++YQN EVGE Sbjct: 383 FKHIDGGFVYQNSDEVGE 400 >3QUR-A nrPDB Length = 286 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 6/50 (12%) Query: 86 GKLWA--TNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYP 133 GKLWA ++ VPE++ P +E LRV+ L VD + + GD I P Sbjct: 162 GKLWAFSSDRVPEVLLPMVEGRLRVVTLTDVDGIVTD----GAGGDTILP 207 >4F5V-A nrPDB Length = 584 Score = 32.3 bits (72), Expect = 0.27, Method: Compositional matrix adjust. Identities = 29/121 (23%), Positives = 54/121 (44%), Gaps = 12/121 (9%) Query: 197 HPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAA 256 HPYF P+LL + Q++ ++T + L++L ++ +AA Sbjct: 146 HPYFYAPELLYYAQKYKAILTECCEAADKGACLTPK-----------LDALKEKALISAA 194 Query: 257 QIVLRF-NIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWR 315 Q LR +IQ+ K++ L R+ + F DF+ + + D+ ++K +LL Sbjct: 195 QERLRCASIQKFGDRAYKAWALVRLSQRFPKADFTDISKIVTDLTKVHKECCHGDLLECA 254 Query: 316 D 316 D Sbjct: 255 D 255 >5Y0V-A nrPDB Length = 578 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 1/61 (1%) Query: 231 VNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFS 290 V P L K L S K Y K A + V+RF ++RGV V+P+ + E +Q D + Sbjct: 234 VTTKRPNLYKFGAL-SPQKVYTKAAIREVVRFGLERGVRVLPEFDAPAHVGEGWQDTDLT 292 Query: 291 L 291 + Sbjct: 293 V 293 >5GHK-A nrPDB Length = 584 Score = 31.6 bits (70), Expect = 0.46, Method: Compositional matrix adjust. Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 10/120 (8%) Query: 197 HPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAA 256 HPYF P+LL + QQ+ V + + + L + LL+S +R+ + Sbjct: 146 HPYFYAPELLYYAQQYKGVFAECCQAADKAACLGPKIEA--LREKVLLSSAKERFKCASL 203 Query: 257 QIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRD 316 Q +F R K++++ R+ + F DF+ + + D+ ++K +LL D Sbjct: 204 Q---KFG-DRAF----KAWSVARLSQRFPKADFAEISKVVTDLTKVHKECCHGDLLECAD 255 >2AEV-A nrPDB Length = 374 Score = 31.2 bits (69), Expect = 0.65, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 29/46 (63%), Gaps = 3/46 (6%) Query: 267 GVVVIPKSFNLERIKENFQI---FDFSLTEEEMKDIEALNKNVRFV 309 G+ K+FNLERI++ F+ FD S E+ K+++A++ N+ V Sbjct: 246 GIYRALKNFNLERIRKAFERAKNFDLSKIEKLNKELKAIDDNINIV 291 >3EB3-A nrPDB Length = 327 Score = 31.2 bits (69), Expect = 0.71, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 101/269 (37%), Gaps = 61/269 (22%) Query: 14 DGNSIPIIGLGTYSEPKSTPKGACATSV-KVAIDTGYRHIDGAYIY---QNEHEVGEAIR 69 G + +GLGT+ A + +A D G D A +Y + E +G I+ Sbjct: 11 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 70 Query: 70 EKIAEGKVRREDIFYCGKLWATN-----------HVPEMVRPTLERTLRVLQLDYVDLYI 118 +K RR + K++A H+ E ++ +LER LQL+YVD+ Sbjct: 71 KK----GWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLER----LQLEYVDVVF 122 Query: 119 IEVPMAFKPGDEIYPRDEN----GKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRR 174 P P +E + G +Y ++ ++ E MEA A R Sbjct: 123 ANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVA-------------R 169 Query: 175 QLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQ-HDIVITA--YSPLGTSRNPIWV 231 Q LI P+ Q E H + + ++ + H I + A +SPL Sbjct: 170 QFNLI--------PPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY 221 Query: 232 NVSSPPL----------LKDALLNSLGKR 250 + PP LKD +L+ G+R Sbjct: 222 DSGIPPYSRASLKGYQWLKDKILSEEGRR 250 >5YXE-A nrPDB Length = 584 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 26/120 (21%), Positives = 53/120 (44%), Gaps = 10/120 (8%) Query: 197 HPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAA 256 HPYF P+LL + +++ V T + V + L++ +L S K K A Sbjct: 146 HPYFYAPELLYYAEEYKGVFTECCEAADKAACLTPKVDA---LREKVLASSAKERLKCA- 201 Query: 257 QIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRD 316 ++Q+ K++++ R+ + F +F+ + + D+ ++K +LL D Sbjct: 202 ------SLQKFGERAFKAWSVARLSQKFPKAEFAEISKLVTDLAKIHKECCHGDLLECAD 255 >5ZF1-A nrPDB Length = 301 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 11/23 (47%), Positives = 15/23 (65%) Query: 196 CHPYFTQPKLLKFCQQHDIVITA 218 CH Y + KL +C+ DI+ITA Sbjct: 197 CHRYTPKDKLEAYCRNADIIITA 219 >3HJE-A nrPDB Length = 704 Score = 27.7 bits (60), Expect = 7.2, Method: Compositional matrix adjust. Identities = 13/25 (52%), Positives = 18/25 (72%), Gaps = 1/25 (4%) Query: 296 MKDIEALNKNVRFVELLMWRDHPEY 320 + DIE L K V++ EL+ WRD+P Y Sbjct: 161 LNDIEKLLK-VQYYELVDWRDYPSY 184 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3G1R-A nrPDB 506 e-144 4JQA-A nrPDB 492 e-139 1Q5M-A nrPDB 489 e-139 5JM5-A nrPDB 487 e-138 2FVL-A nrPDB 485 e-137 2HE8-A nrPDB 477 e-135 5UXF-A nrPDB 471 e-133 1ZUA-X nrPDB 469 e-133 1AFS-A nrPDB 467 e-132 3RX4-A nrPDB 450 e-127 2ALR-A nrPDB 445 e-125 1HQT-A nrPDB 442 e-124 4GAC-A nrPDB 441 e-124 1DLA-A nrPDB 439 e-124 1C9W-A nrPDB 434 e-122 1FRB-A nrPDB 429 e-121 3O3R-A nrPDB 425 e-119 4HBK-A nrPDB 410 e-115 1K8C-A nrPDB 388 e-108 3WCZ-A nrPDB 385 e-107 5Z6T-A nrPDB 384 e-107 5ZCM-A nrPDB 381 e-106 5JH1-A nrPDB 374 e-104 3H7U-A nrPDB 374 e-104 1VBJ-A nrPDB 365 e-101 3H7R-A nrPDB 361 e-100 4GIE-A nrPDB 361 e-100 1QWK-A nrPDB 355 2e-98 4F40-A nrPDB 354 3e-98 2BGQ-A nrPDB 348 2e-96 3KRB-A nrPDB 348 2e-96 1VP5-A nrPDB 342 2e-94 1MZR-A nrPDB 326 6e-90 3D3F-A nrPDB 323 6e-89 4MHB-A nrPDB 321 2e-88 4OTK-A nrPDB 315 1e-86 4IJC-A nrPDB 312 2e-85 1A80-A nrPDB 299 1e-81 3UP8-A nrPDB 283 6e-77 3WG6-A nrPDB 281 3e-76 4H8N-A nrPDB 259 2e-69 1LQA-A nrPDB 209 1e-54 1PYF-A nrPDB 195 3e-50 1PZ1-A nrPDB 172 3e-43 4R9O-A nrPDB 169 1e-42 1OG6-A nrPDB 158 2e-39 Sequences not found previously or not previously below threshold: 3N6Q-A nrPDB 121 5e-28 3EB3-A nrPDB 115 4e-26 2BP1-A nrPDB 78 4e-15 2CLP-A nrPDB 77 1e-14 1GVE-A nrPDB 76 2e-14 2C91-A nrPDB 75 4e-14 4EXA-A nrPDB 70 2e-12 1T6J-A nrPDB 36 0.018 4EHI-A nrPDB 30 1.1 4FO0-A nrPDB 30 1.2 4DBL-A nrPDB 30 1.8 4L1C-A nrPDB 30 1.9 3Q3N-A nrPDB 29 2.5 2WUA-A nrPDB 29 3.4 3MMA-A nrPDB 28 5.1 >3G1R-A nrPDB Length = 346 Score = 506 bits (1302), Expect = e-144, Method: Composition-based stats. Identities = 326/326 (100%), Positives = 326/326 (100%) Query: 1 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 60 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN Sbjct: 21 MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 80 Query: 61 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 120 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE Sbjct: 81 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 140 Query: 121 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 180 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL Sbjct: 141 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 200 Query: 181 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 240 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK Sbjct: 201 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 260 Query: 241 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 300 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE Sbjct: 261 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 320 Query: 301 ALNKNVRFVELLMWRDHPEYPFHDEY 326 ALNKNVRFVELLMWRDHPEYPFHDEY Sbjct: 321 ALNKNVRFVELLMWRDHPEYPFHDEY 346 >4JQA-A nrPDB Length = 331 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 185/324 (57%), Positives = 245/324 (75%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 + + + L+DG+ +P++G GTY+ P PK +VK+AI+ G+ HID A++Y NE Sbjct: 1 MDSKYQCVKLNDGHFMPVLGFGTYA-PAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEE 59 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 +VG AIR KIA+G V+REDIFY KLW+ +H PE+VRP LER+L+ LQLDYVDLY+I P Sbjct: 60 QVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFP 119 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 ++ KPG+E+ P+DENGK L+ +LCATWEAME CKDAGL KS+GVSNFN R LE+ILNK Sbjct: 120 VSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNK 179 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECHPYF Q KLL FC+ DIV+ AYS LG+ R WV+ +SP LL+D Sbjct: 180 PGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDP 239 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L +L K++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT EEMK I+ L Sbjct: 240 VLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGL 299 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 N+NVR++ L ++ P YPF DEY Sbjct: 300 NRNVRYLTLDIFAGPPNYPFSDEY 323 >1Q5M-A nrPDB Length = 322 Score = 489 bits (1259), Expect = e-139, Method: Composition-based stats. Identities = 191/319 (59%), Positives = 239/319 (74%), Gaps = 1/319 (0%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 R+ LSDG+ IP++G GTY+ P+ PK + K+AID G+RHID AY Y+NE EVG A Sbjct: 5 QRVALSDGHFIPVLGFGTYA-PEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLA 63 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 IR KIA+G V+REDIFY KLW T H PE+VRP+LE +L+ LQLDYVDLYII P A KP Sbjct: 64 IRSKIADGTVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKP 123 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 G EI P DE+GK ++ ++CATWEAME CKDAGL KS+GVSNFNRRQLE+ILNKPGLK+ Sbjct: 124 GVEIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKY 183 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 KPV NQVECHPY Q KLL+FC+ IV+ AYS LG+ R P WV+ S+P LL+D L+ +L Sbjct: 184 KPVCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGAL 243 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVR 307 K++ +T A I LR+ +QRG+VV+ KSF +RIKEN Q+F+F L E+MK I++LN+N R Sbjct: 244 AKKHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFR 303 Query: 308 FVELLMWRDHPEYPFHDEY 326 +V HP YPF DEY Sbjct: 304 YVTADFAIGHPNYPFSDEY 322 >5JM5-A nrPDB Length = 332 Score = 487 bits (1255), Expect = e-138, Method: Composition-based stats. Identities = 178/324 (54%), Positives = 240/324 (74%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 + + + L+DG+ +P++G GTY+ P P+ K+AI+ G+RHID A++Y NE Sbjct: 1 MDSKQQCVKLNDGHFMPVLGFGTYA-PPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEE 59 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 +VG AIR KIA+G V+REDIFY KLW+T H PE+VRP LE +L+ QLDYVDLY+I P Sbjct: 60 QVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSP 119 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 M+ KPG+E+ P DENGK ++ +LC TWEAME CKDAGL KS+GVSNFNRRQLE+ILNK Sbjct: 120 MSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNK 179 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECHPYF + KLL FC+ DIV+ AYS LG+ R+ WV+ +SP LL+D Sbjct: 180 PGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDP 239 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L +L K++ +T A I LR+ +QRGVVV+ KS+N +RI++N Q+F+F LT E+MK I+ L Sbjct: 240 VLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGL 299 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 ++N+ + + HP YP+ DEY Sbjct: 300 DRNLHYFNSDSFASHPNYPYSDEY 323 >2FVL-A nrPDB Length = 324 Score = 485 bits (1248), Expect = e-137, Method: Composition-based stats. Identities = 181/324 (55%), Positives = 239/324 (73%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 + R+ L+DG+ +P++G GTY+ P P+ K+AI+ G+RHID AY+Y NE Sbjct: 2 MDPKYQRVELNDGHFMPVLGFGTYA-PPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEE 60 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 +VG AIR KIA+G V+REDIFY KLW T P+MV+P LE +L+ LQLDYVDLY++ P Sbjct: 61 QVGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFP 120 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 MA KPG+ P+DENGK ++ +L ATWE ME CKDAGL KS+GVSNFN RQLE+ILNK Sbjct: 121 MALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNK 180 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECHPY Q KLL FC+ DIV+ A+S LGT R+ +WV+ +SP LL+D Sbjct: 181 PGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDP 240 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L +L K++ +T A I LR+ +QRGVVV+ KS+N +RI+EN Q+F+F LT E+MK ++ L Sbjct: 241 VLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGL 300 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 N+N R+V + DHP+YPF DEY Sbjct: 301 NRNYRYVVMDFLMDHPDYPFSDEY 324 >2HE8-A nrPDB Length = 323 Score = 477 bits (1228), Expect = e-135, Method: Composition-based stats. Identities = 180/324 (55%), Positives = 236/324 (72%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +++ H + L+DGN IP++G GT + P PK K+AID G+ H D A +Y E Sbjct: 1 MNSKCHCVILNDGNFIPVLGFGT-ALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTED 59 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 VGEAIR KIA+G VRREDIFY K+W T+ PE+VR +LER+L+ LQ DYVDLY+I P Sbjct: 60 HVGEAIRSKIADGTVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYP 119 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 MA KPG+E +P DE+GK ++ + +LCATWEAME CKDAGL KS+GVSNFN RQLE+ILNK Sbjct: 120 MALKPGEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNK 179 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECHPY Q KLL FC+ DIV+ AY LGT R WV+ +SP LL + Sbjct: 180 PGLKYKPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEP 239 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L S+ K+YN+T A I LR+ +QRG+VV+ S ERIKEN Q+F+F L+ E+MK ++ L Sbjct: 240 VLGSMAKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGL 299 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 N+N+R++ +++ HP +PF DEY Sbjct: 300 NRNMRYIPAAIFKGHPNWPFLDEY 323 >5UXF-A nrPDB Length = 342 Score = 471 bits (1213), Expect = e-133, Method: Composition-based stats. Identities = 168/324 (51%), Positives = 220/324 (67%), Gaps = 1/324 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +S+ H + L+DG+ IP +G GTY PK PK + +A+D GYRH+D AY YQ E Sbjct: 20 MSSKQHCVKLNDGHLIPALGFGTYK-PKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEE 78 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 E+G+AI+ IA G V+RED+F KLW T PE+V+P LE++L+ LQLDYVDLYI+ P Sbjct: 79 EIGQAIQSAIAAGVVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYP 138 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 + K GD +P +E GK L + C TWE +E CKDAGLVKS+GVSNFN RQLE ILNK Sbjct: 139 VPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNK 198 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECH Y Q KLL +C+ DIV+ AY LGT R WV+ +SP LL D Sbjct: 199 PGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDP 258 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L + K+ ++ A I LR+ IQRG+V + +SF ++EN Q+F F L+ E+MK ++ L Sbjct: 259 VLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGL 318 Query: 303 NKNVRFVELLMWRDHPEYPFHDEY 326 NKN R++ DHPEYPF +EY Sbjct: 319 NKNFRYLPAEFLVDHPEYPFVEEY 342 >1ZUA-X nrPDB Length = 317 Score = 469 bits (1207), Expect = e-133, Method: Composition-based stats. Identities = 161/322 (50%), Positives = 215/322 (66%), Gaps = 5/322 (1%) Query: 5 AASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEV 64 + + LS +PI+GLGT+ +P G +VKVAID GYRHID AY+YQNEHEV Sbjct: 1 HMATFVELSTKAKMPIVGLGTWK----SPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEV 56 Query: 65 GEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 GEAI+EKI E V+RED+F KLW T +VR E+TL+ L+L Y+D+Y+I P Sbjct: 57 GEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQG 116 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 FK GD+++P+D+ G + K+ WEAME D GLVK+LGVSNF+ Q+E +LNKPG Sbjct: 117 FKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPG 176 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 LK+KPV+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + Sbjct: 177 LKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRP-WAKPEDPSLLEDPKI 235 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 + ++ KTAAQ+++RF+IQR V+VIPKS RI EN Q+FDF L++EEM I + N+ Sbjct: 236 KEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNR 295 Query: 305 NVRFVELLMWRDHPEYPFHDEY 326 N R +L +YPF+ EY Sbjct: 296 NWRACNVLQSSHLEDYPFNAEY 317 >1AFS-A nrPDB Length = 323 Score = 467 bits (1202), Expect = e-132, Method: Composition-based stats. Identities = 175/323 (54%), Positives = 232/323 (71%), Gaps = 1/323 (0%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 + + S R+ L+DGN IP++G GT + P+ K + K+AID G+RH D AY+Y+ E Sbjct: 1 MDSISLRVALNDGNFIPVLGFGT-TVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEE 59 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 EVG+AIR KI +G V+REDIFY KLW+T H PE+VR LE+TL+ QLDYVDLYII P Sbjct: 60 EVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFP 119 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 MA +PGD +PRDE+GK L+ ++C TWEAME CKDAGL KS+GVSNFN RQLE ILNK Sbjct: 120 MALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNK 179 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 PGLK+KPV NQVECH Y Q K+L +C+ DI++ +Y LG+SR+ WV+ SP LL D Sbjct: 180 PGLKYKPVCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDP 239 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L ++ K+Y +T A + LR+ +QRGVV + +SFN +RIKE Q+F+F L E+MK ++ L Sbjct: 240 VLCAIAKKYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGL 299 Query: 303 NKNVRFVELLMWRDHPEYPFHDE 325 N+N R+ + DHP +PF DE Sbjct: 300 NRNFRYNNAKYFDDHPNHPFTDE 322 >3RX4-A nrPDB Length = 336 Score = 450 bits (1157), Expect = e-127, Method: Composition-based stats. Identities = 160/323 (49%), Positives = 223/323 (69%), Gaps = 5/323 (1%) Query: 4 SAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63 S + R+ L++G +PI+GLGT+ +P G +VKVAID GYRHID A++YQNE+E Sbjct: 19 SHMASRLLLNNGAKMPILGLGTWK----SPPGQVTEAVKVAIDVGYRHIDCAHVYQNENE 74 Query: 64 VGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123 VG AI+EK+ E V+RE++F KLW T H +V+ ++TL L+LDY+DLY+I P Sbjct: 75 VGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPT 134 Query: 124 AFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKP 183 FKPG E +P DE+G + +N+ TW AME D GLVK++G+SNFN Q+E+ILNKP Sbjct: 135 GFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKP 194 Query: 184 GLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDAL 243 GLK+KP NQ+ECHPY TQ KL+++CQ IV+TAYSPLG+ P W P LL+D Sbjct: 195 GLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRP-WAKPEDPSLLEDPR 253 Query: 244 LNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 + ++ ++NKT AQ+++RF +QR +VVIPKS ERI ENF++FDF L+ ++M + + N Sbjct: 254 IKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYN 313 Query: 304 KNVRFVELLMWRDHPEYPFHDEY 326 +N R LL H +YPFH+E+ Sbjct: 314 RNWRVCALLSCTSHKDYPFHEEF 336 >2ALR-A nrPDB Length = 324 Score = 445 bits (1145), Expect = e-125, Method: Composition-based stats. Identities = 141/331 (42%), Positives = 208/331 (62%), Gaps = 17/331 (5%) Query: 6 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65 A+ + L G +P+IGLGT+ + G +VK A+ GYRHID A IY NE E+G Sbjct: 1 AASCVLLHTGQKMPLIGLGTWK----SEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 56 Query: 66 EAIREKIAEG-KVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 EA++E + G V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 57 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 116 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNFN RQ++ IL+ Sbjct: 117 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 176 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 ++ P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + P LL++ ++ Sbjct: 177 VR--PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVV 233 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 +L ++Y ++ AQI+LR+ +QR V+ IPKS RI +N ++FDF+ + EEMK + ALNK Sbjct: 234 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 293 Query: 305 NVRFVELLMWRD---------HPEYPFHDEY 326 N R++ ++ D HP YPF+D Y Sbjct: 294 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 324 >1HQT-A nrPDB Length = 326 Score = 442 bits (1137), Expect = e-124, Method: Composition-based stats. Identities = 140/331 (42%), Positives = 212/331 (64%), Gaps = 17/331 (5%) Query: 6 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 65 A+ + L G +P+IGLGT+ + G ++K A+ GYRHID A I+ NE E+G Sbjct: 3 AASCVLLHTGQKMPLIGLGTWK----SEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIG 58 Query: 66 EAIREKIAEG-KVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 EA++E + G V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 59 EALQETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 118 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNF+ RQ++ +L+ Sbjct: 119 FERGDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVAS 178 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 244 ++ P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + + P LL++ ++ Sbjct: 179 VR--PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPNEPVLLEEPVV 235 Query: 245 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 +L ++YN++ AQI+LR+ +QR V+ IPKS RI +N Q+FDF+ + EEMK ++ALNK Sbjct: 236 QALAEKYNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNK 295 Query: 305 NVRFVELLMWRD---------HPEYPFHDEY 326 N+RF+ ++ D HP YPF+D Y Sbjct: 296 NLRFIVPMLTVDGKRVPRDAGHPLYPFNDPY 326 >4GAC-A nrPDB Length = 324 Score = 441 bits (1134), Expect = e-124, Method: Composition-based stats. Identities = 137/330 (41%), Positives = 207/330 (62%), Gaps = 17/330 (5%) Query: 7 SHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGE 66 + + L G +P+IGLGT+ + G ++K A+ GYRHID A +Y NE E+GE Sbjct: 2 ASSVLLHTGQKMPLIGLGTWK----SEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGE 57 Query: 67 AIREKIAEG-KVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125 A++E + G V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P AF Sbjct: 58 ALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 117 Query: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGL 185 + GD +P++ +G Y ++ TW+A+E GLVK+LG+SNFN RQ++ +L+ + Sbjct: 118 ERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASV 177 Query: 186 KHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLN 245 + P QVECHPY Q +L+ C + +TAYSPLG+S + W + P LL++ ++ Sbjct: 178 R--PAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSS-DRAWRHPDEPVLLEEPVVL 234 Query: 246 SLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKN 305 +L +++ ++ AQI+LR+ +QR V+ IPKS N RI +N Q+FDF+ + EEMK ++ALNKN Sbjct: 235 ALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKN 294 Query: 306 VRFVELLMWRD---------HPEYPFHDEY 326 R++ ++ D HP YPF+D Y Sbjct: 295 WRYIVPMITVDGKRVPRDAGHPLYPFNDPY 324 >1DLA-A nrPDB Length = 314 Score = 439 bits (1130), Expect = e-124, Method: Composition-based stats. Identities = 157/317 (49%), Positives = 215/317 (67%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L G +PI+GLGT+ +P G +VKVAID GYRHID A++YQNE+EVG ++ Sbjct: 3 LVLYTGAKMPILGLGTWK----SPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQ 58 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EK+ V+RED+F KLW T+H +V+ + TLR L+LDY+DLY+I P FKPG Sbjct: 59 EKLQGQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGK 118 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 + +P D +G + +S+ TWEAME D GLVK++GVSNFN Q+E ILNKPGLK+KP Sbjct: 119 DPFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKP 178 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 NQ+E HPY TQ KL+++C+ IV+TAYSPLG+ P W P LL+D + ++ Sbjct: 179 AVNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRP-WAKPEDPSLLEDPRIKAIAA 237 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 +YNKT AQ+++RF +QR ++VIPKS ERI ENFQ+FDF L+ E+M + + N+N R Sbjct: 238 KYNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVC 297 Query: 310 ELLMWRDHPEYPFHDEY 326 L+ H +YPFH+EY Sbjct: 298 ALMSCASHKDYPFHEEY 314 >1C9W-A nrPDB Length = 315 Score = 434 bits (1115), Expect = e-122, Method: Composition-based stats. Identities = 162/317 (51%), Positives = 209/317 (65%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ +P G +VKVAID GYRHID AY Y NEHEVGEAI+ Sbjct: 4 VELSTKAKMPIVGLGTWQ----SPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQ 59 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E VRRED+F KLW T ++++ ++TL L+LDY+DLY+I P +PG Sbjct: 60 EKIKEKAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E++P+D+ G L K WE ME D GLVK+LGVSNFN Q+E ILNKPGLKHKP Sbjct: 120 ELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKP 179 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P W P LL+D + + Sbjct: 180 VTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRP-WAKPEDPSLLEDPKIKEIAA 238 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT+AQ+++RF+IQR VVVIPKS RI ENFQ+FDF L+++EM I N+N R Sbjct: 239 KHKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRAC 298 Query: 310 ELLMWRDHPEYPFHDEY 326 L + EYP+ EY Sbjct: 299 LLPETVNMEEYPYDAEY 315 >1FRB-A nrPDB Length = 315 Score = 429 bits (1103), Expect = e-121, Method: Composition-based stats. Identities = 156/317 (49%), Positives = 209/317 (65%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS +PI+GLGT+ +P +VK AID GYRHID AY Y NE+EVGEAI+ Sbjct: 4 VELSTKAKMPIVGLGTWK----SPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQ 59 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E V+RED+F KLW T ++++ ++TL L+LDY+DLY+I P +PG Sbjct: 60 EKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E++P+D+ G+ L K+ WE ME D GLVK+LGVSNFN Q+E +LNKPGLKHKP Sbjct: 120 ELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 179 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I +TAYSPLG+ P P LL+D + + Sbjct: 180 VTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPS-AKPEDPSLLEDPKIKEIAA 238 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT+AQ+++RF+IQR VVVIPKS RI+EN Q+FDF L++EEM I + N+N R Sbjct: 239 KHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRAC 298 Query: 310 ELLMWRDHPEYPFHDEY 326 L + EYP+ EY Sbjct: 299 LLPETVNMEEYPYDAEY 315 >3O3R-A nrPDB Length = 316 Score = 425 bits (1092), Expect = e-119, Method: Composition-based stats. Identities = 155/317 (48%), Positives = 206/317 (64%), Gaps = 5/317 (1%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + L +P++GLGT+ +P G +VK AID GYRH D AY+YQNE EVGEAI+ Sbjct: 5 VKLRTKAKMPLVGLGTWK----SPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQ 60 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 EKI E VRRED+F KLW+T +++ ++TL L+LDY+DLY+I P + G Sbjct: 61 EKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGK 120 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 E P+D GK L KS WE ME D GLVK+LGVSNFN Q+E +LNKPGLKHKP Sbjct: 121 EFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 180 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V+NQVECHPY TQ KL+++C I + AYSPLG+ P + P +L+ + + Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRP-YAKPEDPVVLEIPKIKEIAA 239 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 ++ KT AQ+++RF++QR V VIPKS L IKEN Q+FDF L+EE+M I +LN+N R Sbjct: 240 KHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRAC 299 Query: 310 ELLMWRDHPEYPFHDEY 326 L + D ++PFH+EY Sbjct: 300 GLFVTSDEEDFPFHEEY 316 >4HBK-A nrPDB Length = 344 Score = 410 bits (1053), Expect = e-115, Method: Composition-based stats. Identities = 131/317 (41%), Positives = 197/317 (62%), Gaps = 10/317 (3%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + +++G SIP+IGLGT++ +P G +VK A++ GYRH+D AY+Y+NE E+GEA+ Sbjct: 38 LKMNNGRSIPVIGLGTWN----SPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALE 93 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 + +++REDIF KLW T PE VR E TL+ L+L+Y+DLY+I P+ K G Sbjct: 94 NALNSLRLKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGG 153 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 +++P D NG+ TW+ ME D GLVKS+G+SNFN+RQ++ IL + KP Sbjct: 154 DLFPTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEH--CRIKP 211 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 + Q+E H F KL+++ Q + +TAY+PLG+ + + LL + + Sbjct: 212 ANLQIEIHANFPNIKLVEYAQSVGLTVTAYAPLGSPAH----SPGKVNLLTKPCVLEIAH 267 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 R+ KT AQ++LR+ +QR ++V+PKS +RI+ENFQ+FDF L+ EEM ++ + N R Sbjct: 268 RHKKTPAQVLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQF 327 Query: 310 ELLMWRDHPEYPFHDEY 326 LL H EYPF +EY Sbjct: 328 TLLQMSGHQEYPFKEEY 344 >1K8C-A nrPDB Length = 322 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 125/327 (38%), Positives = 179/327 (54%), Gaps = 15/327 (4%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +SA+ I LS G+ +P IG G + +T V AI GYR DGA Y NE Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCWKLANAT----AGEQVYQAIKAGYRLFDGAEDYGNEK 56 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 EVG+ ++ I EG V+RE+IF KLW H P+ V L +TL L++DYVDL++I P Sbjct: 57 EVGDGVKRAIDEGLVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFP 116 Query: 123 MAFK--PGDEIYPR----DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQL 176 +AFK P +E YP + ++Y + TW+A+E AG +KS+GVSNF L Sbjct: 117 IAFKFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALL 176 Query: 177 ELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNV--- 233 +L G KP QVE HPY QPKL++F Q+ + ITAYS G Sbjct: 177 LDLLR--GATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRAL 234 Query: 234 SSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTE 293 ++P L + ++ +YNKT A+++LR+ QRG+ VIPKS ER+ +N F LT+ Sbjct: 235 NTPTLFAHDTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTK 294 Query: 294 EEMKDIEALNKNVRFVELLMWRDHPEY 320 E+ ++I L+ +RF + W + P + Sbjct: 295 EDFEEIAKLDIGLRFNDPWDWDNIPIF 321 >3WCZ-A nrPDB Length = 308 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 126/321 (39%), Positives = 182/321 (56%), Gaps = 16/321 (4%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTY--SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN 60 ++ + I L+DGN+IPI+ LGT + +S +V AI+ GYRHID A +YQ+ Sbjct: 1 MAVQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQD 60 Query: 61 EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE 120 E +VG+ I E IA G V RE++F KLW H + V P L+ +L+ L LDY+DLY+I Sbjct: 61 EEQVGQGIAEAIANGLVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIH 120 Query: 121 VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL 180 P+A KP D + TW+ M+ + GL +S+GVSNFN Q+ ++ Sbjct: 121 FPIATKPDDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLV 169 Query: 181 NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK 240 + +PV NQ+E +P TQ L+ CQ I + AYSP G + + PP Sbjct: 170 SNSY--IRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRG-QTGAPPPRSD 226 Query: 241 DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE 300 D L +L +Y K+ QI+LR+ I RG++ IPKS N +RI +N +FDF LT EE+ I Sbjct: 227 DPTLTALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAIN 286 Query: 301 ALNKNVRFVELLMWRDHPEYP 321 NKN R +++ W+D+P YP Sbjct: 287 QFNKNHRVIDISDWKDYPNYP 307 >5Z6T-A nrPDB Length = 343 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 118/322 (36%), Positives = 173/322 (53%), Gaps = 15/322 (4%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 I L+ G +P +G G + T C+ + AI TGYR DGA Y NE VG Sbjct: 27 PSIKLNSGYDMPAVGFGCWKVDVDT----CSEQIYRAIKTGYRLFDGAEDYANEKLVGAG 82 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK- 126 +++ I EG V+RED+F KLW H P+ V L RTL LQ+DYVDL++I P+ FK Sbjct: 83 VKKAIDEGIVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKF 142 Query: 127 -PGDEIYPR----DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILN 181 P +E YP + + Y + TW+A+E AG ++S+GVSNF L +L Sbjct: 143 VPLEEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLR 202 Query: 182 KPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNV---SSPPL 238 G KP QVE HPY QP+L++F Q I +TAYS G ++ PL Sbjct: 203 --GATIKPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPL 260 Query: 239 LKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKD 298 ++ + ++ ++ K+ AQ++LR++ QRG+ +IPKS + R+ EN + F L E++ D Sbjct: 261 FENETIKAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFAD 320 Query: 299 IEALNKNVRFVELLMWRDHPEY 320 I L+ N+RF + W P + Sbjct: 321 IAKLDINLRFNDPWDWDKIPIF 342 >5ZCM-A nrPDB Length = 341 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 113/322 (35%), Positives = 176/322 (54%), Gaps = 15/322 (4%) Query: 9 RIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAI 68 I L+ G +P++G G + +T CA +V AI GYR D A Y N E+GE I Sbjct: 23 SIKLNSGYEMPLVGFGCWKVDNAT----CADTVYNAIKVGYRLFDAAMDYGNCKEIGEGI 78 Query: 69 REKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK-- 126 + EG V R+++F KLW + H P+ V L++ L ++LDY+DL++I P+AFK Sbjct: 79 NRALDEGLVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFV 138 Query: 127 PGDEIYPR----DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 P +E YP + + Y L TW+AME G KS+G+SNF+ + +L Sbjct: 139 PFEEKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLR- 197 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVN---VSSPPLL 239 G + KP Q+E HPY QP+L+++ Q I ITAYS G + + +P L Sbjct: 198 -GAEIKPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLF 256 Query: 240 KDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDI 299 + + S+ +Y KT AQ++LR+ QR + +IPKS N +R+ +N ++ DF+L++E+ +I Sbjct: 257 EHKTITSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEI 316 Query: 300 EALNKNVRFVELLMWRDHPEYP 321 L++++RF W P Sbjct: 317 SKLDQDLRFNNPWDWDTKNRIP 338 >5JH1-A nrPDB Length = 309 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 120/319 (37%), Positives = 180/319 (56%), Gaps = 22/319 (6%) Query: 7 SHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGE 66 + L+ G IP +GLG++ + G +V A+ GYRHID A +Y NE E+G Sbjct: 1 ARHFVLNTGAKIPSVGLGSWQ----SDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGL 56 Query: 67 AIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFK 126 A+++ EG V+RED+F KLW +H PE V L +L LQL+Y+DLY+I P K Sbjct: 57 ALKKLFEEGVVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVK 116 Query: 127 PGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLK 186 G P + + + ATW AME DAG +++GVSNF+ ++L +L + Sbjct: 117 KGTNTSPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVA--R 168 Query: 187 HKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNS 246 P +QVECHP + Q KL FCQ + +TAYSPLG+ W+N + +LK+ ++ S Sbjct: 169 VPPAVDQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSP-GTTWMNGN---VLKEPIIIS 224 Query: 247 LGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEE------EMKDIE 300 + ++ KT+AQ+ LR+NIQ G V+PKS N ERIK+N ++D+S+ ++ E+K Sbjct: 225 IAEKLGKTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQAR 284 Query: 301 ALNKNVRFVELLMWRDHPE 319 L N +++ H E Sbjct: 285 LLRGNFIVNPESVYKTHEE 303 >3H7U-A nrPDB Length = 335 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 115/321 (35%), Positives = 174/321 (54%), Gaps = 16/321 (4%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 ++ A L+ G P +GLGT+ G +V A+ GYRHID A IY NE Sbjct: 21 MANAITFFKLNTGAKFPSVGLGTWQA----SPGLVGDAVAAAVKIGYRHIDCAQIYGNEK 76 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 E+G +++ + V+RED+F KLW T+H P+ V L RTL+ LQL+YVDLY+I P Sbjct: 77 EIGAVLKKLFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWP 136 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 K G + ++ +TW+AMEA D+G +++GVSNF+ ++L +L Sbjct: 137 ARIKKGSVGIKPEN-----LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLEL 191 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 + P NQVECHP + Q KL +FC+ + ++AYSPLG+ W+ +LK+ Sbjct: 192 A--RVPPAVNQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSP-GTTWLKSD---VLKNP 245 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +LN + ++ K+ AQ+ LR+ +Q G V+PKS N RIKENF +FD+S+ + + Sbjct: 246 ILNMVAEKLGKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEI 305 Query: 303 NKNVRFVELLMWRDHPEYPFH 323 + R V P+ Sbjct: 306 EQ-ARLVTGSFLVHETLSPYK 325 >1VBJ-A nrPDB Length = 281 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 110/307 (35%), Positives = 161/307 (52%), Gaps = 40/307 (13%) Query: 2 DLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNE 61 + A + + LS+G +P++G G + T+ AI +GYRHID A IY+NE Sbjct: 4 EFMALTQSLKLSNGVMMPVLGFGMWKL---QDGNEAETATMWAIKSGYRHIDTAAIYKNE 60 Query: 62 HEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEV 121 G AI A V RE++F KLW ++ E E++++ L L+YVDLY+I Sbjct: 61 ESAGRAI----ASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHW 116 Query: 122 PMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILN 181 P K TW+A E V+++GVSNF+ +E +L Sbjct: 117 P--------------------GKDKFIDTWKAFEKLYADKKVRAIGVSNFHEHHIEELLK 156 Query: 182 KPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKD 241 K P+ NQ+E HP Q L ++C+ +I +TA+SPLG L++D Sbjct: 157 H--CKVAPMVNQIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGH-----------LVED 203 Query: 242 ALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEA 301 A L ++G +Y KTAAQ++LR+ IQ GV+ IPKS N RIKEN IFDF LT E+++ I+ Sbjct: 204 ARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDG 263 Query: 302 LNKNVRF 308 +N R+ Sbjct: 264 MNAGHRY 270 >3H7R-A nrPDB Length = 331 Score = 361 bits (928), Expect = e-100, Method: Composition-based stats. Identities = 113/320 (35%), Positives = 184/320 (57%), Gaps = 21/320 (6%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 ++A L+ G +P +GLGTY+ AT+++ AI GYRHID A IY NE Sbjct: 21 MAAPIRFFELNTGAKLPCVGLGTYAM--------VATAIEQAIKIGYRHIDCASIYGNEK 72 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 E+G +++ I +G V+RE++F KLW+ +H+PE V LE+TL+ LQ+DYVDLY+I P Sbjct: 73 EIGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWP 132 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 + K + + P E + K ++ +TW+AMEA D+G +++GVSNF+ ++L +LN Sbjct: 133 ASLKK-ESLMPTPE----MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNV 187 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 + P NQVECHP + Q L + C+ + ++ YSPLG+ +L++ Sbjct: 188 A--RVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLK----VLQNP 241 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 ++ + ++ KT AQ+ LR+ +Q G V+PKS + R+KEN +FD+S+ E+ + Sbjct: 242 IVTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNI 301 Query: 303 NKNVRFVELLMWRDHPEYPF 322 + +F + H + F Sbjct: 302 PQE-KFCRATEFA-HETHGF 319 >4GIE-A nrPDB Length = 290 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 113/306 (36%), Positives = 170/306 (55%), Gaps = 37/306 (12%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 ++ + + L + +P +GLG + + A +V+ AI+ GYRHID AYIY NE Sbjct: 9 MNCNYNCVTLHNSVRMPQLGLGVWR---AQDGAETANAVRWAIEAGYRHIDTAYIYSNER 65 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 VG+ IRE V RE+++ K+W ++ E ER+ +L L+Y+DLY+I P Sbjct: 66 GVGQGIRE----SGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP 121 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 K TW+A+E + V+++GVSNF L + Sbjct: 122 --------------------GKKKFVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFK- 160 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 K +P+ NQVE HP F Q L +FC+QH+I ITA+SPLG+ +LK+ Sbjct: 161 -SCKIRPMVNQVELHPLFQQRTLREFCKQHNIAITAWSPLGSG--------EEAGILKNH 211 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 +L + K++NK+ AQ+V+R++IQ G+V IPKS N RI+ENF ++DF LTEEEM+ I+ L Sbjct: 212 VLGEIAKKHNKSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDEL 271 Query: 303 NKNVRF 308 N++ R Sbjct: 272 NEDKRI 277 >1QWK-A nrPDB Length = 317 Score = 355 bits (910), Expect = 2e-98, Method: Composition-based stats. Identities = 121/332 (36%), Positives = 179/332 (53%), Gaps = 26/332 (7%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 +S+A+ I LS+G +P+IGLGT+ + T+VK A+ GYR ID A +YQNE Sbjct: 1 MSSATASIKLSNGVEMPVIGLGTWQ----SSPAEVITAVKTAVKAGYRLIDTASVYQNEE 56 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 +G AI+E + EG V+RE++F K W P + L +L+ LQL+YVDLY+ +P Sbjct: 57 AIGTAIKELLEEGVVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMP 116 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 AF + S + W +A AGL K++GVSN+N Q+ L Sbjct: 117 AAFND----------DMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALA- 165 Query: 183 PGLKHKPVSN-QVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSS------ 235 L PV N QVE H YF Q + FC++H+I +T+Y+ LG+ + + Sbjct: 166 --LGLTPVHNSQVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWA 223 Query: 236 --PPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTE 293 P L+D + +L ++ +KT AQ++LR+ + RG ++PKS RIKENF++FDFSLTE Sbjct: 224 PAPSDLQDQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTE 283 Query: 294 EEMKDIEALNKNVRFVELLMWRDHPEYPFHDE 325 E++ +E + R HPE F E Sbjct: 284 EDIAKLEESKNSQRLFLQDFMTGHPEDAFAAE 315 >4F40-A nrPDB Length = 288 Score = 354 bits (909), Expect = 3e-98, Method: Composition-based stats. Identities = 112/299 (37%), Positives = 156/299 (52%), Gaps = 32/299 (10%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 + LS+G +P GLG + P +VK A+ GYRHID A IY+NE VG +R Sbjct: 13 VTLSNGVKMPQFGLGVWQSPAGE---VTENAVKWALCAGYRHIDTAAIYKNEESVGAGLR 69 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 V RED+F KLW T E E + + L +DY+DLY+I P G Sbjct: 70 ----ASGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWP----RGK 121 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 +I + +W A E V+++GVSNF+ LE +L P Sbjct: 122 DILSK--------EGKKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVL--AMCTVTP 171 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 + NQVE HP Q L FC I + A+SPLG + LL + +L+++G Sbjct: 172 MVNQVELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK-----------LLSNPILSAIGA 220 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 +YNKTAAQ++LR+NIQ+ ++ IPKS + ERI+EN IFDF L E++ I+ALN N R+ Sbjct: 221 KYNKTAAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >2BGQ-A nrPDB Length = 344 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 118/315 (37%), Positives = 173/315 (54%), Gaps = 25/315 (7%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAI-DTGYRHIDGAYIYQNEHEVGEAI 68 L G+++P +GLGT+ T A SV+ AI + GYRH+D A Y E EVG+ + Sbjct: 40 FVLKSGHAMPAVGLGTWRAGSDT-----AHSVRTAITEAGYRHVDTAAEYGVEKEVGKGL 94 Query: 69 REKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPG 128 + + G + R+D+F K+W TN PE VRP LE TL+ LQLDY+DLY I P K G Sbjct: 95 KAAMEAG-IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDG 153 Query: 129 DEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHK 188 + P E G+ L + ++ W+ ME GLVK +GV N+ +L +L K Sbjct: 154 AHMPP--EAGEVL--EFDMEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSA--KIP 207 Query: 189 PVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLG 248 P Q+E HP + K+ + C++H I ITAYSPLG+S L D ++ + Sbjct: 208 PAVCQMEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEKN---------LAHDPVVEKVA 258 Query: 249 KRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 + NKT Q+++++ +QRG VIPKS ERIKEN Q+F + + EE+ K + ++ R Sbjct: 259 NKLNKTPGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRV 318 Query: 309 V---ELLMWRDHPEY 320 + EL + + H Y Sbjct: 319 LTGEELFVNKTHGPY 333 >3KRB-A nrPDB Length = 334 Score = 348 bits (892), Expect = 2e-96, Method: Composition-based stats. Identities = 110/314 (35%), Positives = 172/314 (54%), Gaps = 18/314 (5%) Query: 19 PIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIRE--KIAEGK 76 P +G GT+ P A T+V+ A+ TGYRHID AY+YQNE +G A + K A Sbjct: 26 PRLGFGTWQAPPE----AVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSG 81 Query: 77 VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD--EIYPR 134 ++RED++ KLW NH PE+VR ++T+ LQ+DY+DL+++ P+AF D +++P+ Sbjct: 82 IKREDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPK 141 Query: 135 DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQV 194 D G+ + K L TW AME + GLVK +GVSN+ L +LN K KP+ NQ+ Sbjct: 142 DAEGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYA--KIKPLVNQI 199 Query: 195 ECHPYFTQPKLLKFCQQHDIVITAYSPLGTS--RNPIWVNVSSPPLLKDALLNSLGKRYN 252 E HP+ +KFC + I +TAYSP+G S +L+ L ++ Sbjct: 200 EIHPWHPNDATVKFCLDNGIGVTAYSPMGGSYADPRDPSGTQKNVILECKTLKAIADAKG 259 Query: 253 KTAAQIVLRFNIQRGV----VVIPKSFNLERIKENFQIFDFSLTEEEMKDIEA--LNKNV 306 + + L +++++ VIPKS RI+ NF+ + L++++M I LNK + Sbjct: 260 TSPHCVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRI 319 Query: 307 RFVELLMWRDHPEY 320 RF + ++ P + Sbjct: 320 RFCDPAIFWKVPLF 333 >1VP5-A nrPDB Length = 298 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 100/299 (33%), Positives = 160/299 (53%), Gaps = 36/299 (12%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 ++ L++G +PI+G G + P + V AI GYR ID A Y NE VG A Sbjct: 16 PKVTLNNGVEMPILGYGVFQIPPEKTE----ECVYEAIKVGYRLIDTAASYMNEEGVGRA 71 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 I+ I EG VRRE++F KLW ++ E + E++L+ LQL+Y+DLY+I P Sbjct: 72 IKRAIDEGIVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFG--- 128 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 ++ W+AME GLV+++GVSNF +L ++ + Sbjct: 129 ------------------DVHCAWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHH--EI 168 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 P NQ+E HP++ + + ++F + ++I A+ P R + ++ +L S+ Sbjct: 169 VPAVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRKN---------IFQNGVLRSI 219 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNV 306 ++Y KT AQ++LR+ Q+G+V IPK+ ER+KEN IFDF LT+E+M+ I L++ Sbjct: 220 AEKYGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEGQ 278 >1MZR-A nrPDB Length = 296 Score = 326 bits (837), Expect = 6e-90, Method: Composition-based stats. Identities = 97/299 (32%), Positives = 152/299 (50%), Gaps = 39/299 (13%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 I L DGN +P +GLG + T+++ A++ GYR ID A Y+NE VG+A++ Sbjct: 28 IKLQDGNVMPQLGLGVWQASNE----EVITAIQKALEVGYRSIDTAAAYKNEEGVGKALK 83 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 V RE++F KLW +H + R L +L+ LQLDY+DLY++ P+ Sbjct: 84 NA----SVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVPAID-- 135 Query: 130 EIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKP 189 + W+ M + GL+KS+GV NF L+ ++++ G+ P Sbjct: 136 ----------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGV--TP 177 Query: 190 VSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGK 249 V NQ+E HP Q +L + H I ++SPL + ++ L Sbjct: 178 VINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG---------VFDQKVIRDLAD 228 Query: 250 RYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRF 308 +Y KT AQIV+R+++ G+VVIPKS RI ENF ++DF L ++E+ +I L++ R Sbjct: 229 KYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRL 287 >3D3F-A nrPDB Length = 275 Score = 323 bits (829), Expect = 6e-89, Method: Composition-based stats. Identities = 109/305 (35%), Positives = 156/305 (51%), Gaps = 40/305 (13%) Query: 4 SAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63 ++ + L +G +P GLG + SVK AI GYR ID A IY+NE Sbjct: 2 TSLKDTVKLHNGVEMPWFGLGVFKV---ENGNEATESVKAAIKNGYRSIDTAAIYKNEEG 58 Query: 64 VGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123 VG I+E V RE++F K+W + E E++L LQLDY+DLY+I P Sbjct: 59 VGIGIKE----SGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWP- 113 Query: 124 AFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKP 183 K TW A+E G ++++GVSNF LE +L Sbjct: 114 -------------------GKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDA 154 Query: 184 GLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDAL 243 + KP+ NQVE HP TQ +L +C+ I + A+SPL + LL + + Sbjct: 155 --EIKPMVNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ-----------LLDNEV 201 Query: 244 LNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 L + +++NK+ AQ++LR+++Q GVV IPKS RI EN IFDF L++E+M I+ALN Sbjct: 202 LTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALN 261 Query: 304 KNVRF 308 K+ R Sbjct: 262 KDERV 266 >4MHB-A nrPDB Length = 297 Score = 321 bits (824), Expect = 2e-88, Method: Composition-based stats. Identities = 96/296 (32%), Positives = 151/296 (51%), Gaps = 39/296 (13%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 + L++G ++P++G G + T C +V AI+TGYR ID A YQNE +VG A Sbjct: 16 QTVKLNNGIAMPLLGFGVFQM---TNTAECERAVIDAIETGYRLIDTAASYQNETQVGNA 72 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 ++ + R+++F KLW + E + ER+L LQLDYVDLY+I P Sbjct: 73 LK----LSGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYG--- 125 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 ++ W AME AG ++++GVSNF+ +L ++ K Sbjct: 126 ------------------DVHGAWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFN--KI 165 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 P NQ+E +P+ Q + + Q I A++P RN L ++ +L ++ Sbjct: 166 IPAVNQIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNG---------LFQNPVLTAI 216 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 G++Y K+ Q+VLR+ QRG+V + KS R++EN I DF L+ E+M I AL+ Sbjct: 217 GEKYGKSVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALD 272 >4OTK-A nrPDB Length = 318 Score = 315 bits (808), Expect = 1e-86, Method: Composition-based stats. Identities = 98/307 (31%), Positives = 139/307 (45%), Gaps = 39/307 (12%) Query: 4 SAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHE 63 +AA+ I L+D +++P++GLG + +V A++ G R ID AY Y NE Sbjct: 43 AAAAPSITLNDEHTMPVLGLGVAELSDDETER----AVSAALEIGCRLIDTAYAYGNEAA 98 Query: 64 VGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123 VG AI A V RE++F KL + + +L L LDYVDLY+I P Sbjct: 99 VGRAI----AASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPA 154 Query: 124 AFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKP 183 W M + G +S+GVSNF +E +++ Sbjct: 155 P------------------PVGKYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLT 196 Query: 184 GLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDAL 243 + P NQ+E HP Q +L K QH +V +Y PL R LL + Sbjct: 197 FV--TPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR-----------LLDNPT 243 Query: 244 LNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 + S+ Y KT AQ++LR+N+Q G V+ +S ERI NF +FDF L E M + LN Sbjct: 244 VTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLN 303 Query: 304 KNVRFVE 310 R E Sbjct: 304 DGTRVRE 310 >4IJC-A nrPDB Length = 344 Score = 312 bits (799), Expect = 2e-85, Method: Composition-based stats. Identities = 108/325 (33%), Positives = 178/325 (54%), Gaps = 31/325 (9%) Query: 10 IPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 L++G IP +GLGT + + +VK AI GYRHID A+ Y+ E VGEAI+ Sbjct: 25 FSLNNGVRIPALGLGTANPHEKL--AETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIK 82 Query: 70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGD 129 E + +G ++RED+F K+W + + V +L +L+ L L+YVDL + P+ F+ Sbjct: 83 ELLEDGSIKREDLFITTKVWPV--LWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIK 140 Query: 130 EI--------YPRDENGKWLY-HKSNLCATWEAMEACK---DAGLVKSLGVSNFNRRQLE 177 + P D++GK +Y + T++ +E + V+++GVSNF+ LE Sbjct: 141 DPKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLE 200 Query: 178 LILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPP 237 ++ + + KP NQVE HP+ Q +L KFC HDI++TAYSPLG+ P Sbjct: 201 RLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGS---------HGAP 249 Query: 238 LLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMK 297 LK L+ L ++YN T +++ ++I++G +VIP+S N RI + + SLT++E++ Sbjct: 250 NLKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQ 307 Query: 298 DIEALNKNV--RFVELLMWRDHPEY 320 ++ + RF++ PE+ Sbjct: 308 ELNDFGEKYPVRFIDEPFAAILPEF 332 >1A80-A nrPDB Length = 277 Score = 299 bits (765), Expect = 1e-81, Method: Composition-based stats. Identities = 98/296 (33%), Positives = 147/296 (49%), Gaps = 37/296 (12%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEA 67 I L+DGNSIP +G G + P + + +V+ A++ GYRHID A IY NE E Sbjct: 3 PSIVLNDGNSIPQLGYGVFKVPPADTQR----AVEEALEVGYRHIDTAAIYGNE----EG 54 Query: 68 IREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKP 127 + IA + R+D+F KLW H + + +L L LD VDLY++ P Sbjct: 55 VGAAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTP--- 111 Query: 128 GDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 N WE M + AGL +S+GVSN LE I+ G+ Sbjct: 112 ---------------AADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGV-- 154 Query: 188 KPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSL 247 P NQ+E HP + Q ++ + HD+ I ++ PLG + ++ + + Sbjct: 155 VPAVNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYDLFGAEP---------VTAA 205 Query: 248 GKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALN 303 + KT AQ VLR+++Q+G VV PKS ER++EN +FDF LT+ E+ I+A++ Sbjct: 206 AAAHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >3UP8-A nrPDB Length = 298 Score = 283 bits (725), Expect = 6e-77, Method: Composition-based stats. Identities = 96/311 (30%), Positives = 152/311 (48%), Gaps = 43/311 (13%) Query: 3 LSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEH 62 + H + S+G +IP +G GT+ + A+ G+RH+D A IY NE Sbjct: 20 FQSMMHAVS-SNGANIPALGFGTFRM----SGAEVLRILPQALKLGFRHVDTAQIYGNEA 74 Query: 63 EVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVP 122 EVGEAI++ + R D+F K+W N+ + +++ +LR L+ D+VDL ++ P Sbjct: 75 EVGEAIQK----SGIPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWP 130 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNK 182 + A+ ++AG V+ +G+SNFN Q+E Sbjct: 131 -------------------GSDVPMAERIGALNEVRNAGKVRHIGISNFNTTQMEEAARL 171 Query: 183 PGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 +NQVE HPY Q K+L+ ++ + +T+Y + + P D Sbjct: 172 SDAPI--ATNQVEYHPYLDQTKVLQTARRLGMSLTSYYAMANGKVPA-----------DP 218 Query: 243 LLNSLGKRYNKTAAQIVLRFNI-QRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEA 301 LL +G R+ KTAAQ+ LR+ + Q+ V+V+ K+ R+KENF IFDF+LT EEM + Sbjct: 219 LLTEIGGRHGKTAAQVALRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRE 278 Query: 302 LNK-NVRFVEL 311 L + N R V Sbjct: 279 LARPNGRIVNP 289 >3WG6-A nrPDB Length = 307 Score = 281 bits (718), Expect = 3e-76, Method: Composition-based stats. Identities = 97/317 (30%), Positives = 151/317 (47%), Gaps = 39/317 (12%) Query: 3 LSAASHRIPLSDGNSIPIIGLGT----YSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY 58 +S A LS+GN IP + GT + + ++++A+ +G+RHIDGA IY Sbjct: 4 MSLAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIY 63 Query: 59 QNEHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPE-------MVRPTLERTLRVLQL 111 E+G A++ + R+D+F K + NH + L+ L L L Sbjct: 64 GTNKEIGIALKNV----GLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGL 119 Query: 112 DYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNF 171 +YVDLY+I P + H +L W +E K+ GL +++GVSNF Sbjct: 120 EYVDLYLIHFPYISEKS--------------HGFDLVEAWRYLERAKNEGLARNIGVSNF 165 Query: 172 NRRQLELILNKPGLKHKPVSNQVECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTSRNPI 229 L+ IL+ PV NQ+E Y P ++++ QQ I+I AY PLG PI Sbjct: 166 TIENLKSILD-ANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLG----PI 220 Query: 230 WVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDF 289 P D +L+ L ++Y + QI+LR+ +QRG++ I + ERI + +IFDF Sbjct: 221 TQGRPGPL---DKVLSKLSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDF 277 Query: 290 SLTEEEMKDIEALNKNV 306 L +E+ I + K Sbjct: 278 ELDKEDEDQITKVGKEK 294 >4H8N-A nrPDB Length = 310 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 91/302 (30%), Positives = 148/302 (49%), Gaps = 35/302 (11%) Query: 14 DGNSIPI-IGLGT-YSEPK--STPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69 G I I +G GT + + + + ++ + + G+RHID A Y + EVGEA++ Sbjct: 18 SGKEISIALGTGTKWKQAQTINDVSTELVDNILLGLKLGFRHIDTAEAYNTQKEVGEALK 77 Query: 70 EKIAEGKVRREDIFYCGKL---WAT-NHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAF 125 V REDI+ K W + + ++++ L L +DYVDL++I P Sbjct: 78 RT----DVPREDIWVTTKYSPGWGSIKAYSKSPSDSIDKALAQLGVDYVDLFLIHSPF-- 131 Query: 126 KPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILN-KPG 184 H L WEA+ K AG V+ +G+SN LE + P Sbjct: 132 -----------FTTEQTHGYTLEQAWEALVEAKKAGKVREIGISNAAIPHLEKLFAASPS 180 Query: 185 LKHKPVSNQVECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDA 242 ++ PV NQ+E HP+ +++FCQ+H I++ A+SPL V + L + Sbjct: 181 PEYYPVVNQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLAP-----LARVETNALAE-- 233 Query: 243 LLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEAL 302 L L ++Y KT AQ++LR+ +QRG++ + S R+KE+ +FDF LT+EE+ +I + Sbjct: 234 TLKRLAEKYKKTEAQVLLRYTLQRGILPVTTSSKESRLKESLNLFDFELTDEEVNEINKI 293 Query: 303 NK 304 Sbjct: 294 GD 295 >1LQA-A nrPDB Length = 346 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 72/350 (20%), Positives = 134/350 (38%), Gaps = 67/350 (19%) Query: 8 HRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQ-------- 59 HRIP S + +GLGT + + + + A+ G ID A +Y Sbjct: 4 HRIPHSS-LEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQ 62 Query: 60 --NEHEVGEAIREKIAEGKVRREDIFYCGKL----WATNH--------VPEMVRPTLERT 105 E VG + + + RE + K+ + + +R L + Sbjct: 63 GLTETYVGNWLAKHGS-----REKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDS 117 Query: 106 LRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSN------LCATWEAMEACKD 159 L+ LQ DY+DLY + P P + GK Y ++ L T +A+ + Sbjct: 118 LKRLQTDYLDLYQVHWPQR--------PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQR 169 Query: 160 AGLVKSLGVSNFNR----RQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIV 215 AG ++ +GVSN R L L + + N + L + Q + Sbjct: 170 AGKIRYIGVSNETAFGVMRYLHLADKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVE 229 Query: 216 ITAYSPLG-TSRNPIWVNVSSPPLLKDALLN------------------SLGKRYNKTAA 256 + AYS LG + ++N + P ++ L + + +R+ A Sbjct: 230 LLAYSCLGFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPA 289 Query: 257 QIVLRFNIQRGVV--VIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 304 Q+ L F ++ V + + ++++K N + L+E+ + +IEA+++ Sbjct: 290 QMALAFVRRQPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQ 339 >1PYF-A nrPDB Length = 312 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 75/320 (23%), Positives = 134/320 (41%), Gaps = 65/320 (20%) Query: 21 IGLGTYSEP-----KSTPKGACATSVKVAIDTGYRHIDGAYIYQ---NEHEVGEAIREKI 72 IGLGT + + + V+ AI G +D AYIY +E +GE +RE Sbjct: 16 IGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE-- 73 Query: 73 AEGKVRREDIFYCGKL--------WATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 124 RED+ K + ++ P+ ++ +++ +L+ L DY+DL+ I P Sbjct: 74 ----FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP-- 127 Query: 125 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 184 DE P+DE A+ K AG ++S+GVSNF+ QL+ NK G Sbjct: 128 ----DEHTPKDE-------------AVNALNEMKKAGKIRSIGVSNFSLEQLKEA-NKDG 169 Query: 185 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPL--GTSRNPIWVNVSSPP----- 237 L + + + + ++H+I Y PL G + + P Sbjct: 170 L-VDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLRN 228 Query: 238 -------------LLKDALLNSLGKRYNKTAAQIVLRFNIQRGV--VVIPKSFNLERIKE 282 + K L + +++N IVL + + R ++IP + +++ + Sbjct: 229 EQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQLID 288 Query: 283 NFQIFDFSLTEEEMKDIEAL 302 N + D +L++E++ I+ L Sbjct: 289 NIKTADVTLSQEDISFIDKL 308 >1PZ1-A nrPDB Length = 333 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 72/331 (21%), Positives = 128/331 (38%), Gaps = 66/331 (19%) Query: 14 DGNSIPIIGLGTYSEPKS----TPKGACATSVKVAIDTGYRHIDGAYIY---QNEHEVGE 66 G IGLGT++ + T + +++ A+D G ID A Y Q+E VG+ Sbjct: 9 TGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGK 68 Query: 67 AIREKIAEGKVRREDIFYCGKL---WATNHV-----PEMVRPTLERTLRVLQLDYVDLYI 118 AI+E + +R+ + K W N + + +E +L+ LQ DY+DLY Sbjct: 69 AIKEYM-----KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLYQ 123 Query: 119 IEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLEL 178 + P + T E M+ DAG ++++GVSNF+ Q++ Sbjct: 124 VHWPDPL-------------------VPIEETAEVMKELYDAGKIRAIGVSNFSIEQMDT 164 Query: 179 ILNKPGL-KHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTS------------ 225 L +P N E + +L + + + I Y L Sbjct: 165 FRAVAPLHTIQPPYNLFE---REMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEEYTF 221 Query: 226 -------RNPIWVNVSSPP-LLKDALLNSLGK-RYNKTAAQIVLRFNIQRGVVVIP--KS 274 +P + L L+ L K RY K+ + +R+ + + I + Sbjct: 222 EGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADIALWGA 281 Query: 275 FNLERIKENFQIFDFSLTEEEMKDIEALNKN 305 +++ +I ++L E+ KDI + +N Sbjct: 282 RKPGQLEALSEITGWTLNSEDQKDINTILEN 312 >4R9O-A nrPDB Length = 301 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 72/322 (22%), Positives = 127/322 (39%), Gaps = 54/322 (16%) Query: 4 SAASHRIPLS-DGNSIPIIGLGTYSEPK-STPKGACATSVKVAIDTGYRHIDGAYIY--- 58 +A R+ ++ G +G + + + ++ +D G +D A IY Sbjct: 2 NAMVQRVTIAPQGPEFSRFVMGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGY 61 Query: 59 QNEHEVGEAIREKIAEGKVRREDIFYCGK------LWATNHVPEMVRP------TLERTL 106 Q E GEA+ RE + K A N + + + E++L Sbjct: 62 QCEAAFGEALTLAPHL----REKLQIVTKCGIATTARAENKLGHYITDRRHIILSAEQSL 117 Query: 107 RVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSL 166 + L DY+D+ +I P D++ EA + +G V+ Sbjct: 118 KNLATDYLDMLLIHRPDPLMDADDVA-------------------EAFQHLHQSGKVRHF 158 Query: 167 GVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFC----QQHDIVITAYSPL 222 GVSNF Q L+ ++ L +NQVE P QP LL QQ I A+S L Sbjct: 159 GVSNFTPAQFTLLQSR--LPFTLATNQVEISPVH-QPLLLDGTLDQLQQLRIRPMAWSCL 215 Query: 223 GTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAA-QIVLRFNIQRG--VVVIPKSFNLER 279 G R ++ + + PL ++ L+ + + N ++ Q+V + ++ + I S +ER Sbjct: 216 GGGR--LFNDEAYQPLRQE--LSVIAQELNASSIEQVVYAWILRLPSQPLPIIGSGKIER 271 Query: 280 IKENFQIFDFSLTEEEMKDIEA 301 ++ + SLT ++ I Sbjct: 272 VRAALEAETLSLTRQQWFRIRK 293 >1OG6-A nrPDB Length = 298 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 116/307 (37%), Gaps = 47/307 (15%) Query: 15 GNSIPIIGLGTYSEPK-STPKGACATSVKVAIDTGYRHIDGAYIY---QNEHEVGEAIRE 70 G +G + + + ++ +D G +D A IY Q E GEA++ Sbjct: 11 GPEFSRFVMGYWRLMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKL 70 Query: 71 KIAEGKVRREDIFYCGKLWATNH---------VPEMVRPTLERTLRVLQLDYVDLYIIEV 121 + R E + CG + + + E++L L D++DL +I Sbjct: 71 A-PHLRERMEIVSKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHR 129 Query: 122 PMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILN 181 P DE+ +A + +G V+ GVSNF Q L+ + Sbjct: 130 PDPLMDADEVA-------------------DAFKHLHQSGKVRHFGVSNFTPAQFALLQS 170 Query: 182 KPGLKHKPVSNQVECHPYFTQPKLLKFC----QQHDIVITAYSPLGTSRNPIWVNVSSPP 237 + L +NQVE P QP LL QQ + A+S LG R ++ + P Sbjct: 171 R--LPFTLATNQVEISPVH-QPLLLDGTLDQLQQLRVRPMAWSCLGGGR--LFNDDYFQP 225 Query: 238 LLKDALLNSLGKRYNK-TAAQIVLRFNIQRG--VVVIPKSFNLERIKENFQIFDFSLTEE 294 L + L + + N + Q+V + ++ + I S +ER++ + +T + Sbjct: 226 LRDE--LAVVAEELNAGSIEQVVNAWVLRLPSQPLPIIGSGKIERVRAAVEAETLKMTRQ 283 Query: 295 EMKDIEA 301 + I Sbjct: 284 QWFRIRK 290 >3N6Q-A nrPDB Length = 346 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 57/332 (17%), Positives = 126/332 (37%), Gaps = 66/332 (19%) Query: 14 DGNSIPIIGLGTY-SEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQ-----NEHEVGEA 67 G +P + LG + + + ++ A D G H D A Y E G Sbjct: 21 SGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGRL 80 Query: 68 IREKIAEGKVRREDIFYCGK----LWATNHV----PEMVRPTLERTLRVLQLDYVDLYII 119 +RE A R+++ K +W + + + +L+++L+ + L+YVD++ Sbjct: 81 LREDFAAY---RDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYS 137 Query: 120 EVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI 179 + + + T A+ +G +G+S+++ + + + Sbjct: 138 HR-------------------VDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKM 178 Query: 180 LN-KPGLKHKPVSNQ--VECHPYF-TQPKLLKFCQQHDIVITAYSPLGTS---------- 225 + K + +Q + + LL Q + + A++PL Sbjct: 179 VELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNGI 238 Query: 226 -------RNPIWVNVSSPPLLKDA------LLNSLGKRYNKTAAQIVLRFNI--QRGVVV 270 R V +P +L +A LLN + ++ ++ AQ+ L + + R V Sbjct: 239 PQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVTSV 298 Query: 271 IPKSFNLERIKENFQ-IFDFSLTEEEMKDIEA 301 + + E+++EN Q + + + + +E+ I+ Sbjct: 299 LIGASRAEQLEENVQALNNLTFSTKELAQIDQ 330 >3EB3-A nrPDB Length = 327 Score = 115 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 60/339 (17%), Positives = 120/339 (35%), Gaps = 67/339 (19%) Query: 14 DGNSIPIIGLGTY-SEPKSTPKGACATSVKVAIDTGYRHIDGAYIY---QNEHEVGEAIR 69 G + +GLGT+ + + +A D G D A +Y + E +G I+ Sbjct: 11 SGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 70 Query: 70 EKIAEGKVRREDIFYCGKLWATNHV-------PEMVRPTLERTLRVLQLDYVDLYIIEVP 122 +K RR + K++A + + L+ +L LQL+YVD+ P Sbjct: 71 KK----GWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP 126 Query: 123 MAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI--L 180 + + T AM + G+ G S ++ ++ + Sbjct: 127 DP-------------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSV 167 Query: 181 NKPGLKHKPVSNQVECHPYFTQP---KLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPP 237 + P+ Q E H + + +L + + + +SPL + PP Sbjct: 168 ARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPP 227 Query: 238 L----------LKDALLN--------------SLGKRYNKTAAQIVLRFNIQRGVV--VI 271 LKD +L+ ++ +R T Q+ + + ++ V V+ Sbjct: 228 YSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVL 287 Query: 272 PKSFNLERIKENFQIFDF--SLTEEEMKDIEALNKNVRF 308 + N E++ EN L+ + +I+++ N + Sbjct: 288 LGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPY 326 >2BP1-A nrPDB Length = 360 Score = 78.5 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 113/338 (33%), Gaps = 80/338 (23%) Query: 23 LGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY---QNEH-EVGEAIREKIAEGKVR 78 LGT + A A +V+ ++ G+ +D A++Y Q+E G + + +V+ Sbjct: 43 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVK 102 Query: 79 REDIFYCGKLWATN---HVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRD 135 K + P+ VR LE +L+ LQ VDL+ + P Sbjct: 103 -----IATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPD------------ 145 Query: 136 ENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI--LNKPGLKHKPVSNQ 193 H + + T A + G LG+SN+ ++ I L K P Q Sbjct: 146 -------HGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQ 198 Query: 194 VECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTSR--------------------NPIWV 231 + Q +L + + AY+PL W Sbjct: 199 GMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWA 258 Query: 232 NVSSPPLLKDALLNSLG-------KRYNKTAAQI---VLRF-----NIQ--RGVVVIPKS 274 K+ ++ Y +A + LR+ +Q G VI Sbjct: 259 ETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGM 318 Query: 275 FNLERIKENFQIFDFSLTEE---EMKDIEALNKNVRFV 309 +LE++++N TEE E ++A N+ V Sbjct: 319 SSLEQLEQNLAA-----TEEGPLEPAVVDAFNQAWHLV 351 >2CLP-A nrPDB Length = 347 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 62/339 (18%), Positives = 111/339 (32%), Gaps = 74/339 (21%) Query: 19 PIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY---QNEH-EVGEAIREKIAE 74 P LG + A + ++ G+ ID A++Y Q+E G +R ++ Sbjct: 26 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSD 85 Query: 75 GKVRREDIFYCGK---LWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEI 131 +V+ K L+ + P+ +R LE +L+ LQ VDL+ + +P Sbjct: 86 CRVK-----IDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPD-------- 132 Query: 132 YPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI--LNKPGLKHKP 189 H + + T A G LG+SN+ ++ I L K P Sbjct: 133 -----------HSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILP 181 Query: 190 VSNQVECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTSR--------------------N 227 Q + Q +L + + A++PL Sbjct: 182 TVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFG 241 Query: 228 PIWVNVSSPPLLKDALLNSLG-------KRYNKTAAQI---VLRF-----NIQ--RGVVV 270 W + K+ + Y +A + LR+ +Q G V Sbjct: 242 NTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAV 301 Query: 271 IPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 I +LE++++N E ++A N+ V Sbjct: 302 ILGMSSLEQLEQNLAAA--EEGPLEPAVVDAFNQAWHLV 338 >1GVE-A nrPDB Length = 327 Score = 75.8 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 58/334 (17%), Positives = 108/334 (32%), Gaps = 64/334 (19%) Query: 19 PIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN--EHEVGEAIREKIAEGK 76 P LG + + + SV+ + G+ ID A++Y N + + + Sbjct: 6 PATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQSETILGDLGLGLGRSG 65 Query: 77 VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDE 136 + + ++ P VR LE +L+ LQ VDL+ + P Sbjct: 66 CKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFPD------------- 112 Query: 137 NGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI--LNKPGLKHKPVSNQV 194 H + + T +A G LG+SN+ ++ I L K P Q Sbjct: 113 ------HGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQG 166 Query: 195 ECHPYFTQ--PKLLKFCQQHDIVITAYSPLGT----SRNPIWVNVSSPP---LLKDA--- 242 + Q +L + + A++PL R P + Sbjct: 167 MYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESRFFGNPFSQ 226 Query: 243 -----------------LLNSLGKRYNKTAAQI---VLRF---NIQ----RGVVVIPKSF 275 + +L Y TA + +R+ + Q +G VI Sbjct: 227 LYMDRYWKEEHFNGIALVEKALKTTYGPTAPSMISAAVRWMYHHSQLKGTQGDAVILGMS 286 Query: 276 NLERIKENFQIFDFSLTEEEMKDIEALNKNVRFV 309 +LE++++N + E ++A ++ V Sbjct: 287 SLEQLEQNLAL--VEEGPLEPAVVDAFDQAWNLV 318 >2C91-A nrPDB Length = 338 Score = 75.0 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 69/339 (20%), Positives = 117/339 (34%), Gaps = 80/339 (23%) Query: 19 PIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIY---QNEH-EVGEAIREKIAE 74 P LGT + A A SV+ ++ G+ +D A++Y Q+E+ G + + Sbjct: 17 PATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLGSGD 76 Query: 75 GKVRREDIFYCGKL--W-ATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEI 131 V+ K W + P+ +R LE +L+ LQ VDL+ + P Sbjct: 77 CTVK-----IATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPD-------- 123 Query: 132 YPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELI--LNKPGLKHKP 189 H + + T A G LG+SN+ ++ I L K P Sbjct: 124 -----------HSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILP 172 Query: 190 VSNQVECHPYFTQ--PKLLKFCQQHDIVITAYSPLGTSR--------------------N 227 Q + Q +LL + + AY+PL Sbjct: 173 TVYQGMYNATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFG 232 Query: 228 PIWVNVSSPPLLKDALLNSLG--KR-----YNKTAAQI---VLRF-----NIQ--RGVVV 270 W K+ ++ ++ Y A ++ LR+ +Q RG V Sbjct: 233 NNWAETYRNRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAV 292 Query: 271 IPKSFNLERIKENFQIFDFSLTEE---EMKDIEALNKNV 306 I +LE++++N TEE E +EA ++ Sbjct: 293 ILGMSSLEQLEQNLAA-----TEEGPLEPAVVEAFDQAW 326 >4EXA-A nrPDB Length = 292 Score = 69.6 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 89/260 (34%), Gaps = 57/260 (21%) Query: 14 DGNSIPIIGLGTYSEPKST-----------PKGACATSVKVAIDTGYRHIDGAYIYQ-NE 61 G ++ +GLGT + A + +A D G ID A Y +E Sbjct: 38 TGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYGRSE 97 Query: 62 HEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMV--------RPTLERTLRVLQLDY 113 +G +R +RE K+ + V R ++ER+L+ L+ D Sbjct: 98 ERLGPLLRG-------QREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKRLETDR 150 Query: 114 VDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNR 173 ++L ++ D N + S + T + A K GL+ + G+S Sbjct: 151 IELVLVH-------------SDGNDLDILENSEVYPT---LAALKREGLIGAYGLSGKTV 194 Query: 174 RQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQH--DIVI-----TAYSPLGTSR 226 L + + + ++++ H I++ + ++ LG + Sbjct: 195 EGGLRALREGDCAMVT----YNLNER-AERPVIEYAAAHAKGILVKKALASGHACLGAGQ 249 Query: 227 NPIWVNVSSPPLLKDALLNS 246 +P+ + + + + Sbjct: 250 DPVRASFE--LVFDQPGVAA 267 >1T6J-A nrPDB Length = 716 Score = 36.5 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 39/140 (27%), Positives = 54/140 (38%), Gaps = 17/140 (12%) Query: 115 DLYIIEVPMAFKPGD---EIYPRDENGKWLYHKSNLCATWEA--MEACKDAGLVKSLGVS 169 DL + + G + D K +H N A A ME + GL + +G Sbjct: 378 DLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTR-LGLAQ-IGKL 435 Query: 170 NFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAY-SPLGTSRNP 228 NF QL +LN + P E P L C+ DI AY S LG NP Sbjct: 436 NFT--QLTEMLNAGMNRGLPSCLAAE------DPSLSYHCKGLDIAAAAYTSELGHLANP 487 Query: 229 IWVNVSSPPLLKDALLNSLG 248 + +V P + + +NSL Sbjct: 488 VTTHVQ-PAEMANQAVNSLA 506 >4EHI-A nrPDB Length = 534 Score = 30.3 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 11/18 (61%), Positives = 15/18 (83%) Query: 49 YRHIDGAYIYQNEHEVGE 66 ++HIDG ++YQN EVGE Sbjct: 383 FKHIDGGFVYQNSDEVGE 400 >4FO0-A nrPDB Length = 593 Score = 30.3 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 22/65 (33%), Gaps = 7/65 (10%) Query: 87 KLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSN 146 K T+H PE + L ++ +D Y I P+ G G ++ Sbjct: 124 KWTNTSHHPEYLVGE-----EALYVNPLDCYNIHWPIR--RGQLNIHPGPGGSLTAVLAD 176 Query: 147 LCATW 151 + W Sbjct: 177 IEVIW 181 >4DBL-A nrPDB Length = 349 Score = 29.6 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 30/94 (31%), Gaps = 12/94 (12%) Query: 173 RRQLELILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVN 232 R L ++L L Q +P LL + + A LG + P W Sbjct: 81 PRTLAVLLVGAALAISGAVMQALFENPLAEPGLLGVSNGAGVGLIAAVLLGQGQLPNWAL 140 Query: 233 VSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQR 266 L+++ T I+LRF + Sbjct: 141 G----------LSAIAGALIIT--LILLRFARRH 162 >4L1C-A nrPDB Length = 103 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 31/95 (32%), Gaps = 16/95 (16%) Query: 93 HVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWE 152 H+ E + + L ++ ++ P+ P + W Sbjct: 21 HLHEAEPKVIHQALED-KIAQAPAFLKHAPVVLNVSALEDPVN---------------WS 64 Query: 153 AMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKH 187 AM A ++ +GVS QL+ + K GL Sbjct: 65 AMHKAVSATGLRVIGVSGCKDAQLKAEIEKMGLPI 99 >3Q3N-A nrPDB Length = 500 Score = 29.2 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 15/30 (50%), Gaps = 3/30 (10%) Query: 92 NHVPEMVRPTLERTLRVLQLD---YVDLYI 118 + E + ER+L L LD Y DL++ Sbjct: 292 EFMYEWIIGQFERSLIDLGLDKPWYWDLFL 321 >2WUA-A nrPDB Length = 440 Score = 28.8 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 23/46 (50%), Gaps = 2/46 (4%) Query: 214 IVITAY-SPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQI 258 +++ AY SPL ++ + +L +L +L ++ N A++ Sbjct: 36 VIVAAYRSPLCKAKRGGLKDTYPDDILA-PVLKALIEKTNINPAEV 80 >3MMA-A nrPDB Length = 418 Score = 28.0 bits (61), Expect = 5.1, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 19/63 (30%), Gaps = 4/63 (6%) Query: 94 VPEMVRPTLERTLR---VLQLDYVD-LYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCA 149 P + TL L + Y D L+ P FK P D + Sbjct: 178 GPALCEFACYDTLELCYDLTMTYQDELHRPMWPYKFKIKCAGCPNDCVASKARSDFAIIG 237 Query: 150 TWE 152 TW+ Sbjct: 238 TWK 240 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.142 0.431 Lambda K H 0.267 0.0435 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,615,309 Number of Sequences: 36641 Number of extensions: 634153 Number of successful extensions: 2148 Number of sequences better than 10.0: 61 Number of HSP's better than 10.0 without gapping: 102 Number of HSP's successfully gapped in prelim test: 20 Number of HSP's that attempted gapping in prelim test: 1706 Number of HSP's gapped (non-prelim): 124 length of query: 326 length of database: 10,336,785 effective HSP length: 97 effective length of query: 229 effective length of database: 6,782,608 effective search space: 1553217232 effective search space used: 1553217232 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.3 bits)