BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P51649 (535 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2W8P-A nrPDB 994 0.0 3JZ4-A nrPDB 555 e-158 4V6H-A nrPDB 548 e-156 3EK1-A nrPDB 520 e-148 5X5U-A nrPDB 343 8e-95 5VBF-A nrPDB 329 2e-90 3RH9-A nrPDB 320 8e-88 3TY7-A nrPDB 312 2e-85 3K2W-A nrPDB 308 5e-84 5GT6-A nrPDB 301 6e-82 2HG2-A nrPDB 301 7e-82 4PZ2-A nrPDB 299 2e-81 4MPY-A nrPDB 298 6e-81 4PXL-B nrPDB 297 9e-81 5EUY-A nrPDB 290 9e-79 4V3F-A nrPDB 288 3e-78 2D4E-A nrPDB 285 3e-77 3U4J-A nrPDB 282 3e-76 5J77-A nrPDB 281 7e-76 4I8P-A nrPDB 280 1e-75 3RHO-A nrPDB 280 1e-75 1BPW-A nrPDB 276 1e-74 6B4R-B nrPDB 276 1e-74 4X2Q-A nrPDB 276 2e-74 5KLK-A nrPDB 274 8e-74 6QAO-A nrPDB 271 4e-73 5IUV-A nrPDB 271 4e-73 4U3W-A nrPDB 271 7e-73 4O6R-A nrPDB 270 8e-73 3IWJ-A nrPDB 270 8e-73 3I44-A nrPDB 270 9e-73 4GO4-A nrPDB 270 1e-72 4CAZ-A nrPDB 270 2e-72 5AC0-A nrPDB 267 1e-71 1O9J-A nrPDB 266 1e-71 5AC2-A nrPDB 266 1e-71 3IWK-A nrPDB 265 4e-71 5FHZ-A nrPDB 264 7e-71 4O5H-A nrPDB 263 2e-70 5L13-A nrPDB 260 1e-69 3R31-A nrPDB 259 3e-69 1WNB-A nrPDB 257 8e-69 4QYJ-A nrPDB 254 6e-68 3VZ0-A nrPDB 254 6e-68 1AG8-A nrPDB 252 3e-67 6C43-A nrPDB 248 3e-66 3RHD-A nrPDB 248 6e-66 4I8Q-A nrPDB 247 1e-65 4YWE-A nrPDB 243 2e-64 4JZ6-A nrPDB 241 8e-64 4LIH-A nrPDB 240 1e-63 2QE0-A nrPDB 239 1e-63 5N5S-A nrPDB 238 4e-63 3EFV-A nrPDB 236 2e-62 4F3X-A nrPDB 235 4e-62 3R64-A nrPDB 234 7e-62 3B4W-A nrPDB 234 7e-62 4DNG-A nrPDB 223 2e-58 3VZ3-A nrPDB 216 3e-56 5JRY-A nrPDB 215 4e-56 6MVR-A nrPDB 213 1e-55 3PRL-A nrPDB 213 2e-55 1T90-A nrPDB 213 2e-55 3QAN-A nrPDB 212 3e-55 5KF0-A nrPDB 211 8e-55 4OGD-A nrPDB 210 1e-54 5UR2-A nrPDB 207 1e-53 3ROS-A nrPDB 206 2e-53 6FK3-A nrPDB 206 3e-53 1UXV-A nrPDB 197 1e-50 5J6B-A nrPDB 196 2e-50 2JG7-A nrPDB 190 2e-48 4PXN-A nrPDB 189 2e-48 5U0M-A nrPDB 186 2e-47 5TJR-A nrPDB 186 3e-47 3RJL-A nrPDB 182 3e-46 4ZZ7-A nrPDB 182 3e-46 6DBB-A nrPDB 176 3e-44 2J5N-A nrPDB 174 8e-44 4KNA-A nrPDB 174 9e-44 4X0T-A nrPDB 172 2e-43 3JU8-A nrPDB 170 2e-42 4I3V-A nrPDB 165 6e-41 4H7N-A nrPDB 164 1e-40 4E4G-A nrPDB 160 1e-39 5UCD-A nrPDB 135 6e-32 1AD3-A nrPDB 134 1e-31 3SZA-A nrPDB 134 1e-31 4QGK-A nrPDB 134 1e-31 5NNO-A nrPDB 120 2e-27 4LGZ-A nrPDB 100 2e-21 4OE4-A nrPDB 96 4e-20 3V9H-A nrPDB 95 8e-20 3V4C-A nrPDB 91 9e-19 2Y53-A nrPDB 78 9e-15 4IDS-A nrPDB 72 9e-13 1EZ0-A nrPDB 69 5e-12 6D97-A nrPDB 60 2e-09 5J7I-A nrPDB 46 5e-05 5DBV-A nrPDB 44 2e-04 3K9D-A nrPDB 44 3e-04 5UJU-A nrPDB 43 3e-04 3MY7-A nrPDB 37 0.022 5JFN-A nrPDB 37 0.027 5HCE-A nrPDB 35 0.069 1FUP-A nrPDB 32 0.65 5YDP-A nrPDB 31 1.1 3SLK-A nrPDB 30 2.5 2PZM-A nrPDB 29 5.0 4APM-A nrPDB 28 8.2 >2W8P-A nrPDB Length = 487 Score = 994 bits (2571), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/487 (99%), Positives = 486/487 (99%) Query: 49 GRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 108 GRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA Sbjct: 1 GRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 60 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 168 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS Sbjct: 61 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 120 Query: 169 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK Sbjct: 121 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 180 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT Sbjct: 181 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 240 Query: 289 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT VCSNQFLV Sbjct: 241 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLV 300 Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT Sbjct: 301 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 360 Query: 409 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG Sbjct: 361 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 420 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK Sbjct: 421 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 480 Query: 529 YVCYGGL 535 YVCYGGL Sbjct: 481 YVCYGGL 487 >3JZ4-A nrPDB Length = 481 Score = 555 bits (1430), Expect = e-158, Method: Compositional matrix adjust. Identities = 267/478 (55%), Positives = 351/478 (73%), Gaps = 6/478 (1%) Query: 58 LLRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 L R + + G WL A V +PA+G LG V G E RAA+ AA A WR + Sbjct: 7 LFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRALPAWRAL 66 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVY 175 +AKER+++LR W+NLM++++DDLAR++T E GKPL EA GEI Y+A F+EWF+EE +R+Y Sbjct: 67 TAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAEEGKRIY 126 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 GD I D+R +V+KQPIGV A ITPWNFP+AMITRK G ALAAGCT+V+KPA TPF Sbjct: 127 GDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPF 186 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 SALALAELA +AG+P+GV+NV+ S A VG + ++PLV K+SFTGST G+ L+ Sbjct: 187 SALALAELAIRAGVPAGVFNVVTGS---AGAVGNELTSNPLVRKLSFTGSTEIGRQLMEQ 243 Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 A +K+VS+ELGG APFIVFD A++D+AV GA+ASKFRN GQTCVC+N+ VQ G++D Sbjct: 244 CAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDR 303 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415 F + +AM K L +G+G + G T GPLI+EKAV KVE+ + DA+ KGA VV GGK H+ Sbjct: 304 FAEKLQQAMSK-LHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAHER 362 Query: 416 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 475 G NFF+PT+L +V + + EETFGPLAP+ +F E + IA AN + GLA YFY++D Sbjct: 363 GGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDL 422 Query: 476 AQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 ++++RV E LE G+VG+N G+IS+ PFGG+K SGLGREGSKYGI++YLE+KY+C G Sbjct: 423 SRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIG 480 >4V6H-A nrPDB Length = 484 Score = 548 bits (1413), Expect = e-156, Method: Compositional matrix adjust. Identities = 271/477 (56%), Positives = 353/477 (74%), Gaps = 6/477 (1%) Query: 57 ALLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWRE 114 +LLR +++GG W A ATF V DPA+G +LG V G E A+ AA A+ WR Sbjct: 9 SLLRHQAYIGGEWQAADSDATFEVFDPATGESLGTVPKMGAAETARAIEAAQAAWAGWRM 68 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRV 174 +AKER+++LR+W++L+I N DDLA I+T E GKPL EA GEI Y+A F+EWF+EE +RV Sbjct: 69 KTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEAKGEIAYAASFIEWFAEEGKRV 128 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 GD + TP ++R +V+K+PIGV A ITPWNFP+AMI RKVG ALAAGC +VVKPAE TP Sbjct: 129 AGDTLPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVVKPAESTP 188 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 FSALA+A LA +AG+P GV +V+ + K +G I ++P+V K+SFTGST G++L+ Sbjct: 189 FSALAMAFLAERAGVPKGVLSVV---IGDPKAIGTEITSNPIVRKLSFTGSTAVGRLLMA 245 Query: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 +A +VK++++ELGG APFIVFD A++D AV GA+ASK+RN GQTCVC+N+F V ++D Sbjct: 246 QSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHERVYD 305 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 AF A A+ K L+VG G E G T GPLINE AV+KVE + DA++KGA+++TGGKRH Sbjct: 306 AFADKLAAAVSK-LKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGKRHA 364 Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 LG FFEPT+L V DM EETFGPLAP+ +F +EEE + +AN + GLA Y YS+D Sbjct: 365 LGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLYSRD 424 Query: 475 PAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 ++WRVAE LE GMVG+N GLIS+ PFGGVKQSGLGREGS YGID+Y+ +KY+C Sbjct: 425 IGRVWRVAEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYVVIKYLC 481 >3EK1-A nrPDB Length = 504 Score = 520 bits (1340), Expect = e-148, Method: Compositional matrix adjust. Identities = 268/492 (54%), Positives = 348/492 (70%), Gaps = 8/492 (1%) Query: 42 AQLRCYAGRLAGLSAALLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREAR 99 AQ + LA +LL++ V GRW+ AA T V +PA G+ +G V V + Sbjct: 14 AQTQGPGSMLALKDPSLLKSQCLVNGRWIDAADGTTIKVTNPADGSVIGTVPSLSVATIK 73 Query: 100 AAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILY 159 A+ A+ +A W +AKER+ +LRKW++L+I N DD+A I+T+E GKPL EA GE+LY Sbjct: 74 EAIDASAKALSGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEARGEVLY 133 Query: 160 SAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAAL 219 +A F+EWF+EEA+RVYGD I P +R V++QP+GV A ITPWNFP+AMITRK AL Sbjct: 134 AASFIEWFAEEAKRVYGDTIPAPQNGQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPAL 193 Query: 220 AAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSK 279 AAGCT++V+PA+ TP +ALAL LA +AGIP+GV ++ A+E+G + ++ V K Sbjct: 194 AAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIV---TGKAREIGAELTSNDTVRK 250 Query: 280 ISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 339 +SFTGST G++L+ A ++KR+S+ELGG APFIVFD A++D AV GAM SK+RN GQT Sbjct: 251 LSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKYRNAGQT 310 Query: 340 CVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDA 399 CVC+N+ VQRG++D F + A A K L+VGNG E G GP+I EKA+ KV+ + DA Sbjct: 311 CVCANRIYVQRGVYDKFAEKLA-AKVKELKVGNGTEPGVVIGPMIEEKAITKVKAHIEDA 369 Query: 400 VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 459 VSKGA ++TGGK +LG FFEP +L VT DML EETFGPLAP+ FDTEEE IA A Sbjct: 370 VSKGAKLITGGK--ELGGLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQA 427 Query: 460 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 519 N GLA YFY+++ ++ RV+E LE GMVG N GLIS+ PFGGVKQSGLGREGSKY Sbjct: 428 NDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEVAPFGGVKQSGLGREGSKY 487 Query: 520 GIDEYLELKYVC 531 GI+EYLE KY+C Sbjct: 488 GIEEYLETKYIC 499 >5X5U-A nrPDB Length = 505 Score = 343 bits (881), Expect = 8e-95, Method: Compositional matrix adjust. Identities = 194/473 (41%), Positives = 276/473 (58%), Gaps = 6/473 (1%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAK 118 T + G W+ AA+ T V +PA+G +G VA G+ + A+ AA F WR+V A Sbjct: 33 TQLLIDGEWVDAASGKTIDVVNPATGKPIGRVAHAGIADLDRALAAAQSGFEAWRKVPAH 92 Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI 178 ER++ +RK L+ + D +A+++T E GKPL EA E+L +A +EWF++E RRVYG I Sbjct: 93 ERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARVEVLSAADIIEWFADEGRRVYGRI 152 Query: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238 + + V+K+P+G A TPWNFP + RK+ AALA GC+ +VK E+TP S Sbjct: 153 VPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVKAPEETPASPA 212 Query: 239 ALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298 AL AG+P+GV ++ + E+ + P++ K++FTGST GK L A Sbjct: 213 ALLRAFVDAGVPAGVIGLV---YGDPAEISSYLIPHPVIRKVTFTGSTPVGKQLASLAGL 269 Query: 299 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVK 358 +KR +MELGG AP IV + A+V AV A +KFRN GQ C+ +FLV I D F + Sbjct: 270 HMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHNSIRDEFTR 329 Query: 359 AFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN 418 A + + L+VGNG EEGTT G L N + + + +++A GA++ TGG+R N Sbjct: 330 ALVK-HAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGASIETGGERIGSEGN 388 Query: 419 FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI 478 FF PT++ NV D + E FGP+A + FD EEAIA AN GLAGY +++ A + Sbjct: 389 FFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGYAFTRSFANV 448 Query: 479 WRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + ++LEVGM+ +N+ E PFGGVK SG G EG ++ YL K V Sbjct: 449 HLLTQRLEVGMLWINQPATPWPEMPFGGVKDSGYGSEGGPEALEPYLVTKSVT 501 >5VBF-A nrPDB Length = 478 Score = 329 bits (844), Expect = 2e-90, Method: Compositional matrix adjust. Identities = 190/469 (40%), Positives = 272/469 (57%), Gaps = 6/469 (1%) Query: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERS 121 ++ GR+ A T PV DP + LG + + AAV+AA+ AF WR S RS Sbjct: 10 YIDGRFHDADGRRTQPVVDPGTTRVLGELPHATAHDIDAAVQAAHRAFVTWRHESPLVRS 69 Query: 122 SLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHT 181 LLR+ L + + + R IT + GKPL+EA E++ +A LEW +EE RR YG ++ Sbjct: 70 DLLRRAAALARERAETIGRHITMDQGKPLREAIAEVVSAAEQLEWHAEEGRRTYGRVVPA 129 Query: 182 PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALA 241 + D VL++PIGV A +PWNFP + K+ AALA+GCT+V+K E++P + +ALA Sbjct: 130 RSPDVMQTVLREPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPSAIVALA 189 Query: 242 ELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVK 301 +L AG+P G N++ +V + + P V KISFTGS GK L AA+ +K Sbjct: 190 QLFHDAGLPPGCLNIV---WGVPGDVSKQLIEAPQVRKISFTGSVPVGKQLAALAASLMK 246 Query: 302 RVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFA 361 R++MELGG AP +V A+V++A A A KFRN GQ CV +F VQR D FV A+ Sbjct: 247 RMTMELGGHAPVLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFVCAYL 306 Query: 362 EAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFE 421 +A+ +RVG G + G T GPL + + V++++ V DA +KGA + TGG R ++F Sbjct: 307 DAV-GTIRVGYGLDAGVTMGPLAHARRVDEIDAFVADATAKGAQIATGGMRLPGPGHYFA 365 Query: 422 PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRV 481 PT++ T+D ++E FGP+ ++ FD ++A+A AN GLA Y ++ R+ Sbjct: 366 PTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSARNAHRI 425 Query: 482 AEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + LE GMV +N + E PFGGVK SG G EG D YL K+V Sbjct: 426 SRALEAGMVNINHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGYLVTKFV 474 >3RH9-A nrPDB Length = 506 Score = 320 bits (821), Expect = 8e-88, Method: Compositional matrix adjust. Identities = 189/482 (39%), Positives = 278/482 (57%), Gaps = 7/482 (1%) Query: 55 SAALLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRW 112 S L ++GGRW +A ATF V +PA+G+ + V + AAV A A Sbjct: 6 SPLLENLTGYIGGRWKDSAGGATFDVYNPATGSVIAKVPSMPEEDVVAAVEAGQSALRLT 65 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR 172 + R L + + +N++++ RI+ E GKP KEA GE+ Y+A F ++ ++ Sbjct: 66 NPWPIETRRKWLEDIRDGLKENREEIGRILCMEHGKPWKEAQGEVDYAAGFFDYCAKHIS 125 Query: 173 RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + I KD V +P+GV +I PWNFP MI +K+ AALAAGC V+KPA + Sbjct: 126 ALDSHTIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPASE 185 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 TP + +A + + +P G+ N++ A +G+ +C V +SFTGST G+ L Sbjct: 186 TPLTMIAFFSVMDKLDLPDGMVNLV---MGKASVIGKVLCEHKDVPMLSFTGSTEVGRKL 242 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + A VK++++ELGG APFIVFD A+++ A +A+KFR GQTCVC+N+ V + Sbjct: 243 IVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKV 302 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 DAF + AE + K + VG+G +G GPLIN++ +KV++ + DA+ KGA++V G + Sbjct: 303 ADAFGQKLAERVNK-MTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAGKQP 361 Query: 413 HQLGKN-FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 +LG FF PT++ V ++M C EETFGPL P+ F TEEE I N + GLA Y + Sbjct: 362 AELGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVF 421 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + D + RVA L G VG N G + E PFGG+K SG+GREG G+ E++E + V Sbjct: 422 TADAERAQRVAAGLRFGHVGWNTGTGPTPEAPFGGMKASGIGREGGLEGLFEFVEAQTVP 481 Query: 532 YG 533 G Sbjct: 482 RG 483 >3TY7-A nrPDB Length = 478 Score = 312 bits (800), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 183/484 (37%), Positives = 265/484 (54%), Gaps = 30/484 (6%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAK 118 T ++ G W+ + + T V +PA+ +G VA + AV AA + + +R S K Sbjct: 8 TKQYINGEWVESNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYLEFRHTSVK 67 Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPL---KEAHGEILYSAFF-----LEWFSEE 170 ER +LL K KDD+ + IT E G PL + H ++ + F L+ + E Sbjct: 68 ERQALLDKIVKEYENRKDDIVQAITDELGAPLSLSERVHYQMGLNHFVAARDALDNYEFE 127 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 RR GD LV+K+ IGV+ +ITPWNFP+ + K+ AA AAG VV+KP+ Sbjct: 128 ERR--GD----------DLVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPS 175 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E+TPF+A+ LAE+ + G+P GV+N++ + VG + P V +SFTGS TG Sbjct: 176 EETPFAAVILAEIFDKVGVPKGVFNLV---NGDGAGVGNPLSEHPKVRMMSFTGSGPTGS 232 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 ++ AA K+VS+ELGG +P+IV D ++ +A NTGQ C + LV Sbjct: 233 KIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPN 292 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG- 409 I DAF+ E + +RVGN E+GT GP+I++K ++V+ +N + +GA + G Sbjct: 293 KIKDAFLAELKEQFSQ-VRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGG 351 Query: 410 -GKRHQLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467 GK L K +F PT+ NV M EE FGP+ VI ++ +EAI IAN GLA Sbjct: 352 PGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLA 411 Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 GY +D + +VA +E G V +NE + PFGG KQSGLGRE YGI+E+LE+ Sbjct: 412 GYVIGKDKETLHKVARSIEAGTVEINEAG-RKPDLPFGGYKQSGLGREWGDYGIEEFLEV 470 Query: 528 KYVC 531 K + Sbjct: 471 KSIA 474 >3K2W-A nrPDB Length = 497 Score = 308 bits (788), Expect = 5e-84, Method: Compositional matrix adjust. Identities = 169/474 (35%), Positives = 272/474 (57%), Gaps = 10/474 (2%) Query: 63 SFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120 +F+GG+++P+ + T + P++G +G + +A A+ A A W +++A+ R Sbjct: 15 NFIGGQYVPSNESDTIDILSPSTGKVIGEIPAGCKADAENALEVAQAAQKAWAKLTARTR 74 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180 ++LR + N + +NK LA ++ AE GK L A E+ +A F+++ + A + GDI+ Sbjct: 75 QNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEMEVDVTATFIDYGCDNALTIEGDILP 134 Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240 + +D + + K P GV IT WNFP A+ RK+G AL G T+V+KP ++TP + L Sbjct: 135 SDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQETPLATTEL 194 Query: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300 +A +AG+P GV NVI VG+ +C P+ I+ TGST GK + +A + Sbjct: 195 GRIAKEAGLPDGVLNVI---NGTGSVVGQTLCESPITKMITMTGSTVAGKQIYKTSAEYM 251 Query: 301 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF 360 V +ELGG AP +V D A++D+A A+ +F N GQ C C + V ++D F+ F Sbjct: 252 TPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYDEFMAKF 311 Query: 361 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL----G 416 + K L+VG+ + + GP N++ ++ ++ V++A+ +GATV TGGK + G Sbjct: 312 L-PLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATVEGFEG 370 Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476 ++EPT+L +V QD + HEETFGP+ P++K + E+AI N + GL+ Y ++Q A Sbjct: 371 GCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVHTQSFA 430 Query: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 I + LEVG V +N G+ + G KQSG G E K+G+++YLE K V Sbjct: 431 NINQAISDLEVGEVYINRGMGEQHQGFHNGWKQSGFGGEDGKFGLEQYLEKKTV 484 >5GT6-A nrPDB Length = 508 Score = 301 bits (770), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 171/472 (36%), Positives = 267/472 (56%), Gaps = 10/472 (2%) Query: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAKE 119 F+ G ++ A TF +PA+ L +V + + AAV+AA AF W E++ E Sbjct: 37 FINGEFVSAIGGKTFETYNPATEDVLAVVCEAQEEDIDAAVKAARSAFESGPWAEMTTAE 96 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178 R+ L+ K +L+ +++++LA++ ++GKP + A +I + +++ ++ G Sbjct: 97 RAHLIYKLADLIEEHREELAQLEALDNGKPYQVALDDDISATVENYRYYAGWTTKIIGQT 156 Query: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238 I +KD +P+GV I PWNFP M + K+GAALA GCT+V+KPAE TP S L Sbjct: 157 IPI-SKDYLNYTRHEPVGVVGQIIPWNFPLVMSSWKMGAALATGCTIVLKPAEQTPLSLL 215 Query: 239 ALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298 A+L +AG P+GV N +P E G AI + K++FTGST TGK ++ +A Sbjct: 216 YAAKLFKEAGFPNGVVNFVPGF---GPEAGAAIVNHHDIDKVAFTGSTVTGKYIMRQSAE 272 Query: 299 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVK 358 +K V++ELGG +P I+ + A++++A+ GA N GQ C ++ V R ++ V Sbjct: 273 MIKHVTLELGGKSPNIILEDADLEEAINGAFQGIMYNHGQNCSAGSRVFVHRKHYETVVD 332 Query: 359 AFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN 418 A + M N+++G G E+ T GPL+++K E+V + +GATV GG+R Sbjct: 333 ALVK-MANNVKLGAGMEKETEMGPLVSKKQQERVLNYIEQGKKEGATVAAGGERALEKGY 391 Query: 419 FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI 478 F +PT+ +VT DM EE FGP+ V+ FD+ EE I AN + GLA ++Q+ Sbjct: 392 FVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEEVIERANNSSYGLAAGVWTQNIKTG 451 Query: 479 WRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +VA +L+ G V +N+ + + PFGG KQSG+GRE Y +D Y E+K V Sbjct: 452 HQVANKLKAGTVWINDYNLENAAAPFGGYKQSGIGRELGSYALDNYTEVKSV 503 >2HG2-A nrPDB Length = 479 Score = 301 bits (770), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 168/458 (36%), Positives = 269/458 (58%), Gaps = 5/458 (1%) Query: 74 ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQ 133 A V +PA+ A + + D +AR A+ AA A W + A ER+S LRK + + Sbjct: 22 AWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRE 81 Query: 134 NKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQ 193 +++ +I E GK + A E+ ++A ++++ +E ARR G+II + L+ K+ Sbjct: 82 RASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKR 141 Query: 194 PIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGV 253 +GV I PWNFP +I RK+ AL G T+V+KP+E TP +A+A A++ + G+P GV Sbjct: 142 ALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGV 201 Query: 254 YNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPF 313 +N++ + VG+ + +P V+ +S TGS + G+ ++ AA ++ +V +ELGG AP Sbjct: 202 FNLV---LGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPA 258 Query: 314 IVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNG 373 IV D A+++ AV + S+ N+GQ C C+ + VQ+GI+D FV EAM+ ++ GN Sbjct: 259 IVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQA-VQFGNP 317 Query: 374 FEEG-TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDM 432 E GPLIN A+E+VE++V AV +GA V GGK + ++ PTLL +V Q+M Sbjct: 318 AERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEM 377 Query: 433 LCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGV 492 HEETFGP+ PV+ FDT E+AI++AN +D GL Y+Q+ + + L+ G + Sbjct: 378 SIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYI 437 Query: 493 NEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 N +++ G ++SG+G K+G+ EYL+ + V Sbjct: 438 NRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVV 475 >4PZ2-A nrPDB Length = 534 Score = 299 bits (766), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 182/480 (37%), Positives = 278/480 (57%), Gaps = 14/480 (2%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVS 116 T F+ G ++ A + TF +DP +G + VA+ + AVRAA AF W +S Sbjct: 51 TKLFINGSFVDAVSGRTFDTRDPRTGGVIASVAEADKEDVDLAVRAARAAFDHGEWPRMS 110 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGK-PLKEAHGEILYSAFFLEWFSEEARRVY 175 ER ++ + +L+ ++ +LA + + ++GK P ++ +A L +F+ A +++ Sbjct: 111 GSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDVGNAAGSLRYFAGAADKIH 170 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G+ + P + + L++P+GVA VI PWNFPS M KV ALAAGC +VVKPAE TP Sbjct: 171 GETLKMPGQ-FQGHTLREPLGVAGVIIPWNFPSTMFAVKVAPALAAGCALVVKPAEQTPL 229 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 SAL LA+LA QAG+P GV NV+P A G A+ + V +SFTGST G++++ Sbjct: 230 SALYLAQLAKQAGVPDGVINVVPGFGPTA---GAALASHMDVDMVSFTGSTEVGRLIMKA 286 Query: 296 AANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 +A S +K V +ELGG +P IVFD A++D AV A+ + F N G+ CV +++ VQ ++D Sbjct: 287 SAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNKGEACVAASRVYVQERVYD 346 Query: 355 AFVKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR- 412 F + AE M+ + VG+ F + QGP +++ E+V ++ +GAT++TGG+ Sbjct: 347 RFEERLAERMRSWV-VGDPFSDPRADQGPQVDKAQYERVLSYIDHGKREGATLLTGGRPC 405 Query: 413 HQLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 GK ++ EPT+ NV +DM+ EE FGP+ ++KF T EEAIA AN GL Sbjct: 406 APEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVEEAIARANDTRYGLGAGVV 465 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 ++D RV + G+V VN +CPFGG K SG G++ + +D+YL +K V Sbjct: 466 TRDLDVANRVVRSVRAGVVWVNCYFAMGSDCPFGGRKMSGFGKDEGMHALDKYLAVKSVV 525 >4MPY-A nrPDB Length = 520 Score = 298 bits (762), Expect = 6e-81, Method: Compositional matrix adjust. Identities = 168/483 (34%), Positives = 281/483 (58%), Gaps = 16/483 (3%) Query: 59 LRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWRE 114 L ++ G W+ +A T + +P + + V++ +A A+ AA AF W + Sbjct: 31 LSQRQYIDGEWVESANKNTRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGEWSQ 90 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEI--LYSAFFLEWFSEEAR 172 +A+ R +R + + ++++ LAR+ T ++GK L+E++ ++ +++ F +F+ A Sbjct: 91 ETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHNVFM--YFAGLAD 148 Query: 173 RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + G++I +P D + ++K+P+GV ITPWN+P + K+ ALA GC++V+KP+E Sbjct: 149 KDGGEMIDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEI 208 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 TP + + + EL + G P G N+I + EVG+ + V +SFTG TGK + Sbjct: 209 TPLTTIRVFELMEEVGFPKGTINLILGA---GSEVGDVMSGHKEVDLVSFTGGIETGKHI 265 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + +AAN+V +++ELGG P I+FD A+ + AV A+ + + GQ C ++ LVQ I Sbjct: 266 MKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSI 325 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 D F +A + +KK +++GNGF+ T GP+I+ + K+E ++ A ++GAT+ GGKR Sbjct: 326 KDKFEQALIDRVKK-IKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKR 384 Query: 413 HQLGKN----FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 FFEPT++ N M EE FGP+ V F+TE+EAI +AN + GLAG Sbjct: 385 PDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAG 444 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 +S+D + RVA +L++G V +N+ + P+GG KQSG+GRE K G++EYL K Sbjct: 445 AVFSKDIGKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEYLVSK 504 Query: 529 YVC 531 ++ Sbjct: 505 HIL 507 >4PXL-B nrPDB Length = 517 Score = 297 bits (760), Expect = 9e-81, Method: Compositional matrix adjust. Identities = 177/477 (37%), Positives = 268/477 (56%), Gaps = 11/477 (2%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVS 116 T F+ G+++ A + TF +DP +G + +A+ + AV+AA EAF W ++ Sbjct: 37 TKLFIDGKFVDAVSGKTFETRDPRTGEVIASIAEGDKADVDLAVKAAREAFDNGPWPRMT 96 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175 ER +L ++ +L+ ++ ++LA + T ++GK +I +A L +++ A +V+ Sbjct: 97 GYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVGKARDIPGAAHLLRYYAGAADKVH 156 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G + A+ LK+P+GV I PWN+P+ M KVG ALAAGC VVVKPAE TP Sbjct: 157 GATLKM-AQRMHGYTLKEPVGVVGHIVPWNYPTTMFFFKVGPALAAGCAVVVKPAEQTPL 215 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 SAL A LA +AG+P+GV NV+P A G A+ V K+SFTGST G++++ Sbjct: 216 SALFYAHLAREAGVPAGVLNVVPGFGPTA---GAAVAAHMDVDKVSFTGSTEVGRLVMRA 272 Query: 296 AANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 AA S +K VS+ELGG +P IVFD A++D AV + + N G+ CV + VQ GI+D Sbjct: 273 AAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFATYTNKGEICVAGTRIYVQEGIYD 332 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 FVK AE K++ VG+ F +QGP +++ EKV + ++ +GAT+VTGGK Sbjct: 333 EFVKKAAELASKSV-VGDPFNPSVSQGPQVDKDQYEKVLRYIDIGKREGATLVTGGKPCG 391 Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 + EPT+ +V DM +E FGP+ ++KF T EE I AN GLA +++ Sbjct: 392 DKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTVEEVIQKANNTRYGLAAGIVTKN 451 Query: 475 PAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 V+ + G + +N + PFGG K SG G++ +D+YL+ K V Sbjct: 452 IDVANTVSRSIRAGAIWINCYFAFDPDAPFGGYKMSGFGKDMGMDALDKYLQTKTVV 508 >5EUY-A nrPDB Length = 491 Score = 290 bits (743), Expect = 9e-79, Method: Compositional matrix adjust. Identities = 153/478 (32%), Positives = 272/478 (56%), Gaps = 11/478 (2%) Query: 58 LLRTDSFVGGRWL-PAAATFPVQ-DPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 +++ +++ G + P+ F V+ P G+ + V G +AR A+ +A+EA W + Sbjct: 6 IMKVANYINGEFKEPSTGAFQVKTSPVDGSKIAEVPRSGREDAREAIDSAFEALKAWANI 65 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVY 175 A R+ L K + Q K+D +I+T E G ++ GE++++ ++ +E AR Sbjct: 66 PAIRRAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVWGEVVFTERLIQNAAELARHYQ 125 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G ++ + ++ ++V K+ GV VITPWN+P ++ +K+ LA G TVV KPA DTP Sbjct: 126 GRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVVYKPASDTPV 185 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 + +A++ ++AG+P GV+N++ VGE I T V+ ++FTG ++TG+ + Sbjct: 186 TGWLIAQMVAKAGLPKGVFNLVIGP---GPVVGEEIVTHKRVAHVTFTGESSTGREIAAK 242 Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 AA ++K V++ELGG P I+ D +VD A A+ + + GQ C + + +V + + D Sbjct: 243 AAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIVHKAVADK 302 Query: 356 FVKAFAEAMKKNLRVGN-GFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 F++ + +K LR+ + +E GPLINE+ V +++ V+DAVS+G ++ GG+ Sbjct: 303 FIERYVHYVKM-LRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLIGGRSW- 360 Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 NFFEP + +V ++ EE FGP+ P++ + +++A+ +AN D GL+G + + Sbjct: 361 --GNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSGAVLTNN 418 Query: 475 PAQIWRVAEQLEVGMVGVNE-GLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + +R+AE +E GM +N+ + PFGG+K SG+GREG ++ E ++V Sbjct: 419 VNRAFRIAEAVESGMFHINDVTFLEESHVPFGGIKASGVGREGGEWSFHETTYDRWVT 476 >4V3F-A nrPDB Length = 497 Score = 288 bits (738), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 170/476 (35%), Positives = 265/476 (55%), Gaps = 13/476 (2%) Query: 64 FVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAKE 119 F+ G W PV +P++ +G + + AV AA AF R W S Sbjct: 11 FIDGEWREPIKKNRIPVINPSTEEIIGDIPAATAEDVEVAVVAARRAFRRNNWSATSGAH 70 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI- 178 R++ LR + + KD ++ T +SGKP EA +I A E+F+ +A + G Sbjct: 71 RATYLRAIAAKITEKKDHFVKLETIDSGKPFDEAVLDIDDVASCFEYFAGQAEALDGKQK 130 Query: 179 --IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 + P + ++ VL+QP+GV +I+PWN+P M T K+ ALAAGCT V+KP+E + Sbjct: 131 APVTLPMERFKSHVLRQPLGVVGLISPWNYPLLMATWKIAPALAAGCTAVLKPSELASVT 190 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 L E+ ++ G+P GV N++ +A G + + P V KI+FTGS+ TG ++ A Sbjct: 191 CLEFGEVCNEVGLPPGVLNILTGLGPDA---GAPLVSHPDVDKIAFTGSSATGSKVMASA 247 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A VK V++ELGG +P +VF+ ++D+ V + F GQ C +++ LV I F Sbjct: 248 AQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCFWTNGQICSATSRLLVHESIAAEF 307 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR-HQL 415 V + KN+++ + FEEG GP+I++ +K+ K ++ A S+GAT++ GG R L Sbjct: 308 VDKLVK-WTKNIKISDPFEEGCRLGPVISKGQYDKIMKFISTAKSEGATILYGGSRPEHL 366 Query: 416 GKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 K ++ EPT++ +++ M EE FGP+ V F +E+EAIA+AN + GLA +S D Sbjct: 367 KKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSEDEAIALANDTEYGLAAAVFSND 426 Query: 475 PAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + R+ + LEVG V VN V+ P+GG+K+SG GRE ++GI YL +K V Sbjct: 427 LERCERITKALEVGAVWVNCSQPCFVQAPWGGIKRSGFGRELGEWGIQNYLNIKQV 482 >2D4E-A nrPDB Length = 515 Score = 285 bits (730), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 175/505 (34%), Positives = 273/505 (54%), Gaps = 25/505 (4%) Query: 47 YAGRLAGLSAALLR----------TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCG 94 YA R+AG+S + F+ G ++P+ + TFP DPA+ LG+ A G Sbjct: 3 YADRVAGISWETIEEVRRRLKERPALHFIAGEFVPSESGETFPSLDPATNEVLGVAARGG 62 Query: 95 VREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH 154 RE A +AA+EAF RW AKER L + L+ ++ D+LA + ++G+ L+ Sbjct: 63 EREVDRAAKAAHEAFQRWSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVR 122 Query: 155 GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRK 214 ++ +A +++E A D +D ++ P G +ITPWN P + T + Sbjct: 123 AQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWR 182 Query: 215 VGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTD 274 + ALA G TVV+KPAE +PF+A LAE+ +A +P GV+N++ + +E G A+ Sbjct: 183 IAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLV---QGFGEEAGAALVAH 239 Query: 275 PLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFR 334 PLV ++ TG T TGKI++ +AA+ +KR+S ELGG +P +VF A++++A+ + F Sbjct: 240 PLVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFS 299 Query: 335 NTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEK 394 G+ C S++ LV+ I + FV E + +RVG+ + T GPLI+ + +++V Sbjct: 300 FNGERCTASSRLLVEEKIFEDFVGKVVE-RARAIRVGHPLDPETEVGPLIHPEHLQRVLG 358 Query: 395 QVNDAVSKGATVVTGGKR-------HQLGK-NFFEPTLLCNVTQDMLCTHEETFGPLAPV 446 V +GA ++ GG+R L + N+ PT+ M EE FGP+ Sbjct: 359 YVEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVA 417 Query: 447 IKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGG 506 I F EEEA+ AN GLA Y +++D + R+A +LE GMV +N + + PFGG Sbjct: 418 IPFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGG 477 Query: 507 VKQSGLGREGSKYGIDEYLELKYVC 531 VK SG REG Y +D Y +LK + Sbjct: 478 VKGSGDRREGGTYALDFYTDLKTIA 502 >3U4J-A nrPDB Length = 528 Score = 282 bits (721), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 161/422 (38%), Positives = 243/422 (57%), Gaps = 9/422 (2%) Query: 112 WREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEA 171 W +S ERS L+ K +L++ +++LA I + E GKP+ +A GEI + A + + +A Sbjct: 79 WPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQARGEIGFCADLWSYAAGQA 138 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 R + G + DR LVL++P+GV +ITPWNFP + + +V A+ +GCTVV+KP+E Sbjct: 139 RALEGQTHNNIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSE 198 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 T +++ LAELA +AGIP GV+NV+ A G+ + DP V ++FTGS G Sbjct: 199 FTSGTSIRLAELAREAGIPDGVFNVVTGYGDPA---GQVLAEDPNVDMVAFTGSVRVGTK 255 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 L AA +VKRV +ELGG P IVF A++D A G + N GQ C+ ++ LVQ G Sbjct: 256 LGEIAARTVKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQEG 315 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 I DA ++ + +K + G+ E T G +I+E EKV V ++ GA ++ GG+ Sbjct: 316 IRDALMERLLDISRK-VAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGE 374 Query: 412 RHQLGKN---FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 R +G+ ++ PT+ VT DM EE FGP+ + F T +EA+A+ANA + GL+ Sbjct: 375 R--IGREAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSA 432 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 +S + + ++ G +N + + E P GG K+SGLGRE +YG DEY + K Sbjct: 433 SVWSTNLETALQTIRRIRAGRCWINSVIDGTPELPIGGYKKSGLGRELGRYGFDEYSQFK 492 Query: 529 YV 530 V Sbjct: 493 GV 494 >5J77-A nrPDB Length = 508 Score = 281 bits (718), Expect = 7e-76, Method: Compositional matrix adjust. Identities = 161/485 (33%), Positives = 268/485 (55%), Gaps = 15/485 (3%) Query: 59 LRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 + T ++ G+W+ +++ T P +G +G + + A+ AA +AF W ++ Sbjct: 1 MDTKLYIDGQWVNSSSGKTVDKYSPVTGQVIGRMEAATRDDVDRAIDAAEDAFWAWNDLG 60 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 + ERS ++ + L+ +N+ +L II E+GKP+KEA E+ +++++E AR++ G Sbjct: 61 SVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAKEEVDGVIDQIQYYAEWARKLNG 120 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 +++ + R+ K P G+ +TPWNFP+ M+ RK+ AL G TVV+KP+ DTP S Sbjct: 121 EVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNTVVLKPSSDTPGS 180 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A + +AG+P GV N I E+G+ I V+ I+ TGST TG+ ++ A Sbjct: 181 AEWIVRKFVEAGVPKGVLNFITG---RGSEIGDYIVEHKKVNLITMTGSTATGQRIMQKA 237 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 + ++ ++ +ELGG APF+V+ A++D A+ + +K+ N GQ+C+ + + V I+D F Sbjct: 238 SANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLYVHEDIYDTF 297 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 + F E +K L +G+ + GPLIN+ A++ + V +A GA ++ GG + L Sbjct: 298 MSRFVELSRK-LALGD--PKNADMGPLINKGALQATSEIVEEAKESGAKILFGGSQPSLS 354 Query: 417 ---KN--FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 +N FF PT++ N Q EE F P+ K + EE +AN GLA Y + Sbjct: 355 GPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDNKYGLASYLF 414 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK--Y 529 ++DP I+ +E++ G + VN + + G + +G EGSKYGI EYL+LK Y Sbjct: 415 TKDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGISEYLKLKNIY 474 Query: 530 VCYGG 534 V Y G Sbjct: 475 VDYSG 479 >4I8P-A nrPDB Length = 520 Score = 280 bits (716), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 179/482 (37%), Positives = 267/482 (55%), Gaps = 22/482 (4%) Query: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR-----WREVS 116 FV G W P A PV +P + A +G + + AAV AA A R W Sbjct: 28 FVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGRDWARAP 87 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR---R 173 R+ LR +I+ K +LA++ + GKP EA ++ A E+F+++A + Sbjct: 88 GAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQAEALDK 147 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + P + + + ++PIGV +ITPWN+P M T K+ ALAAGCT V+KP+E Sbjct: 148 RQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLKPSELA 207 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 + L LA++ + G+PSGV N++ +A G + P V K++FTGS TGK ++ Sbjct: 208 SVTCLELADICKEVGLPSGVLNIVTGLGPDA---GAPLSAHPDVDKVAFTGSFETGKKIM 264 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 AA VK V++ELGG +P +VFD ++D+AV + F GQ C +++ L IH Sbjct: 265 ASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLL----IH 320 Query: 354 DAFVKAFAEAM---KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 K F E M KN++V + EEG GP+++E EK++K +++A S+GAT++TGG Sbjct: 321 TKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGG 380 Query: 411 KRH-QLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 R L K FF EPT++ ++T M EE FGP+ V +F TE+EAI +AN GLAG Sbjct: 381 VRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAG 440 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 S D + R++E+++ G + VN + P+GG K+SG GRE + GID YL +K Sbjct: 441 AVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVK 500 Query: 529 YV 530 V Sbjct: 501 QV 502 >3RHO-A nrPDB Length = 517 Score = 280 bits (716), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 168/480 (35%), Positives = 275/480 (57%), Gaps = 15/480 (3%) Query: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAKE 119 F+GG ++ A + T+ +P G+ + V+ V + AV AA EAF W +++A++ Sbjct: 40 FIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINARD 99 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178 R LL + ++M Q++++LA I ++G A + S +F+ ++ G Sbjct: 100 RGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGAT 159 Query: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 I A+ R L L K+P+GV ++ PWN+P M++ K A LAAG TVV+KPA+ TP Sbjct: 160 IPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 219 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 +AL AEL +AGIP GV N++P S VG+ + P V KI FTGST GK ++ Sbjct: 220 TALKFAELTLKAGIPKGVVNILPGS---GSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 276 Query: 296 AA-NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 A ++VK+VS++LGG +P I+F ++++AV M+S F N G+ C+ + + V+ IH+ Sbjct: 277 CALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHN 336 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 FV+ E ++K +++GN E T GP +E + K+ + V +GAT+V GG + Sbjct: 337 QFVQKVVEEVEK-MKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVP 395 Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAI-AIANAADVGLAGYFYS 472 FF+PT+ +V M EE+FGP+ + +F D + +A+ + ANA + GLA ++ Sbjct: 396 RPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFT 455 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 +D + V+++L+ G V +N + V PFGG KQSG G++ + ++EYL +K V + Sbjct: 456 RDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTVTF 515 >1BPW-A nrPDB Length = 503 Score = 276 bits (706), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 170/487 (34%), Positives = 266/487 (54%), Gaps = 17/487 (3%) Query: 55 SAALLRTD--SFVGGRWLPA---AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF 109 + +++ TD ++ GGR + + A T PV +PA+G L + CG E AV++A A+ Sbjct: 12 TGSVVVTDDLNYWGGRRIKSKDGATTEPVFEPATGRVLCQMVPCGAEEVDQAVQSAQAAY 71 Query: 110 CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE 169 +W +++ ERS ++ + ++ + +D++A++ +GK + EA +I + +E+++ Sbjct: 72 LKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEYDIDAAWQCIEYYAG 131 Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 A + G I P A ++P+GV A I WN+P + K ALA G VV KP Sbjct: 132 LAPTLSGQHIQLPG-GAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKP 190 Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289 + TP + + LAE+ +AG+P G+ NV+ + E G +C P V+K+SFTGS TG Sbjct: 191 SPMTPVTGVILAEIFHEAGVPVGLVNVV----QGGAETGSLLCHHPNVAKVSFTGSVPTG 246 Query: 290 KILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 K ++ +A +VK V++ELGG +P ++F ++ AV GA+ + F GQ C + VQ Sbjct: 247 KKVMEMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQ 306 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 R I F++ + K + VG+ T G LI++ ++KV V A +GA V+ G Sbjct: 307 REIMPQFLEEVVKRTKA-IVVGDPLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCG 365 Query: 410 GK-----RHQLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 G+ +L +F P +L N DM C EE FGP+ V+ FDTEEE + AN Sbjct: 366 GEPLTPSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTT 425 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 523 GLA +++D ++ RVA LE G +N IS VE PFGG K SG GRE + +D Sbjct: 426 FGLASGVFTRDISRAHRVAANLEAGTCYINTYSISPVEVPFGGYKMSGFGRENGQATVDY 485 Query: 524 YLELKYV 530 Y +LK V Sbjct: 486 YSQLKTV 492 >6B4R-B nrPDB Length = 497 Score = 276 bits (706), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 171/475 (36%), Positives = 264/475 (55%), Gaps = 14/475 (2%) Query: 63 SFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAK 118 +FV G + AA+ TF P G L VA C + +A AV+ A AF W ++ Sbjct: 22 AFVNGEYSNAASGETFDCLSPVDGRFLAKVASCDLADAEQAVKVARNAFDSGAWSRLAPA 81 Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGD 177 +R + ++ +L+++N ++LA + T + GKP+ ++ H ++ +A L W +E ++Y + Sbjct: 82 KRKQTMIRFADLLLENAEELALLETLDMGKPISDSLHIDVASAANSLRWSAEAIDKIYDE 141 Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 + TP + LV ++P+GV A I PWNFP M K+G ALA G +V++KP+E +P +A Sbjct: 142 VAATPHAEL-GLVTREPVGVVAAIVPWNFPLLMSCWKLGPALATGNSVILKPSEKSPLTA 200 Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 + +A+LA +AGIP GV+NV+P VG+A+ V + FTGST K L+ +A Sbjct: 201 IRIAQLAVEAGIPKGVFNVLPGY---GHTVGKALALHMDVDTLVFTGSTKIAKQLMVYAG 257 Query: 298 NS-VKRVSMELGGLAPFIVF-DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 S +KRV +E GG +P IVF D+ ++ A A + N G+ C ++ LV+R I D Sbjct: 258 ESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIAFNQGEVCTAGSRLLVERSIKDK 317 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR--H 413 F+ EA+K + GN + T G L++ + + V + + GA +V GGKR Sbjct: 318 FLPLVIEALK-GWKPGNPLDPETNVGALVDTQQMNTVLSYIEAGHNDGAKLVAGGKRTLE 376 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + G + EPT+ VT M EE FGP+ VI+F+ EEA+ IAN GLA ++ Sbjct: 377 ETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDAEEAVRIANDTPYGLAAAVWTS 436 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 + ++ A+ L G V VN+ + PFGG KQSG GR+ S + D+Y ELK Sbjct: 437 NLSKAHLTAKALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELK 491 >4X2Q-A nrPDB Length = 504 Score = 276 bits (706), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 174/481 (36%), Positives = 254/481 (52%), Gaps = 20/481 (4%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115 T F+ W + + FPV +PA+G + V + + AV+AA AF WR + Sbjct: 24 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 83 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170 A ER LL K +L+ +++ LA + + GKP +A G I ++ W Sbjct: 84 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 139 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA Sbjct: 140 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 198 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E TP SAL + L +AG P GV N++P A G AI + + KI+FTGST GK Sbjct: 199 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTA---GAAIASHIGIDKIAFTGSTEVGK 255 Query: 291 ILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 ++ A S +KRV++ELGG +P I+F A++D AV A F N GQ C ++ V+ Sbjct: 256 LIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVE 315 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + + V++GA + G Sbjct: 316 ESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECG 374 Query: 410 GKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 GK F EPT+ NVT DM EE FGP+ +++F T +E I AN +D GL Sbjct: 375 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAA 434 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 ++ D + V+ ++ G V +N + + PFGG K SG GRE ++G+ EY E+K Sbjct: 435 VFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 494 Query: 530 V 530 V Sbjct: 495 V 495 >5KLK-A nrPDB Length = 520 Score = 274 bits (700), Expect = 8e-74, Method: Compositional matrix adjust. Identities = 159/479 (33%), Positives = 262/479 (54%), Gaps = 13/479 (2%) Query: 63 SFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF-CRWREVSAKERS 121 +++ G ++ +A++F +P +G + V + ++ AV AA A W ++S ++R+ Sbjct: 42 NYIDGNFVTSASSFANINPVNGKLISDVFEADAKQVNEAVVAAQNALKGPWGKLSVQDRA 101 Query: 122 SLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYGDIIH 180 +L+ K + + ++ A++G+P+ +A +I + F++ A+ + D+ Sbjct: 102 ALIHKIADGIQARFEEFVAAEVADTGRPVHQARTLDIPRAIANFRTFADLAKTSHTDLFE 161 Query: 181 TPAKDRRA---LVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 D +++P+GV VI+PW+ P + T KV ALA G TVV KP+E++P SA Sbjct: 162 MSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPSEESPSSA 221 Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 LAE+ AG+P GV+N+I K++ GE + P +S ++FTG + TG ++ A Sbjct: 222 TLLAEVMHDAGVPPGVFNLIHGFGKDS--AGEFLTQHPGISALTFTGESKTGSTIMKAVA 279 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 + VK VS ELGG +VF A++D A+ G + S F N+GQ C+CS + V R I D FV Sbjct: 280 DGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSIFDEFV 339 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 + + L VG ++G GPLI+ +KV AV +GATVVTGG + Sbjct: 340 SGL-KVEAERLVVGYPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGVPKFND 398 Query: 418 N-----FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 + +PT+ ++ C EE FGP+ + FD E+E I N ++ GLA ++ Sbjct: 399 ERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSNYGLACAIWT 458 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + ++ RV+ Q+ VG+V VN + + PFGGVK SGLGREG ++ +D Y ++ +C Sbjct: 459 TNLSRAHRVSRQIHVGLVWVNTWYLRDLRTPFGGVKLSGLGREGGRFSMDFYSDIANIC 517 >6QAO-A nrPDB Length = 508 Score = 271 bits (694), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 164/474 (34%), Positives = 254/474 (53%), Gaps = 14/474 (2%) Query: 66 GGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 G R PA A T +PA+G + G +E AV+ A AF W + S ER + Sbjct: 31 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 90 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPA 183 L + ++ + +D++A + +GK + EA +I S LE+++ A + G+ I P Sbjct: 91 LLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPG 150 Query: 184 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL 243 ++P+GV I WN+P + + K ALA G +V KP+ TP SAL LAE+ Sbjct: 151 GSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 209 Query: 244 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRV 303 S+AG+P G++NV+ + G+ +C P V+K+SFTGS TG ++ +A +K V Sbjct: 210 YSEAGVPPGLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 265 Query: 304 SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEA 363 ++ELGG +P I+F +++ AV GA+ + F GQ C + VQ+ I D F + + Sbjct: 266 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 325 Query: 364 MKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH-----QLGKN 418 ++ +++G+ E T GPLIN +E+V V A +GA V+ GG + +L Sbjct: 326 TQR-IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 384 Query: 419 FF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 ++ P +L N DM C EE FGP+ ++ FDTE E + AN GLA +++D + Sbjct: 385 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 444 Query: 478 IWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 RV +L+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC Sbjct: 445 AHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 498 >5IUV-A nrPDB Length = 497 Score = 271 bits (694), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 172/475 (36%), Positives = 260/475 (54%), Gaps = 14/475 (2%) Query: 63 SFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAK 118 +F+ G + AA+ TF P G L VA C +A+ AV +A AF W ++ Sbjct: 22 AFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDSGAWSRLAPA 81 Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYGD 177 +R + + ++ L+ QN ++LA + T + GKP+ ++ G +I A L W E ++Y + Sbjct: 82 KRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSGEAIDKLYDE 141 Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 + TP D+ LV ++P+GV A I PWNFP M K+G AL+ G +VV+KP+E +P +A Sbjct: 142 VAATP-HDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKPSEKSPLTA 200 Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 + +A+LA +AGIP+GV NV+P VG+A+ V + FTGST K L+ +A Sbjct: 201 IRIAQLAIEAGIPAGVLNVLPGY---GHTVGKALALHMDVDTVVFTGSTKIAKQLMIYAG 257 Query: 298 NS-VKRVSMELGGLAPFIVF-DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 S +KRV +E GG +P IVF D+ ++ A A ++ N G+ C ++ LV+R I D Sbjct: 258 ESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVERSIKDR 317 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR--H 413 F+ EA+ + GN + T G L++ + + V + + GA +V GGK+ Sbjct: 318 FLPMVIEAL-GTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGKQILQ 376 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + G + EPT+ V M EE FGP+ V+ FDT EEAI IAN GLA ++ Sbjct: 377 ETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAAVWTA 436 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 + ++ A L G V VN+ + PFGG KQSG GR+ S + D+Y ELK Sbjct: 437 NLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELK 491 >4U3W-A nrPDB Length = 505 Score = 271 bits (692), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 180/484 (37%), Positives = 255/484 (52%), Gaps = 15/484 (3%) Query: 58 LLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA-FCRWREVS 116 LLR ++ G ++ + TFP P G L V + +AV+AA+ A WR+ + Sbjct: 23 LLR--HYINGEFVASGTTFPNLSPVDGRKLADVCEADAALVDSAVQAAHAAQKAGWRDTT 80 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175 +R++ L K + + D+ A++G+P+ +A +I F++ R Sbjct: 81 PAQRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTLDIARGIANFRTFADLVRTAS 140 Query: 176 GDIIHTPAKDRRAL---VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 G+ T A D L V ++P+GV +I+PWN P + T KV ALA G VV KP+E+ Sbjct: 141 GEYFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKPSEE 200 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 TP SA LAE+ G+P GV+N+I +NA GE + P +S I+FTG + TG + Sbjct: 201 TPSSATLLAEVMHDVGLPPGVFNLIHGHGQNA--AGEFLTRHPDISAITFTGESRTGSTI 258 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + A+ VK VS ELGG +VF A+ D AVAG + S F N GQ C+CS + V+R I Sbjct: 259 MKAVADGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVERPI 318 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 + FV A E + LRVG + TT GPLI+ +KV AV +GATVVTGG Sbjct: 319 FERFVAALKE-QAQALRVGAPEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGGA 377 Query: 413 HQLGKN-----FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467 G F PT+ + C EE FGP+ + FD E E + N + GLA Sbjct: 378 PSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGLA 437 Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 ++ A+ RVA+Q+E G+V VN + + PFGG K SGLGREG ++ +D Y EL Sbjct: 438 ASIWTTQLARGHRVAKQIETGIVWVNAWFVRDLRTPFGGTKLSGLGREGGRHSLDFYSEL 497 Query: 528 KYVC 531 VC Sbjct: 498 TNVC 501 >4O6R-A nrPDB Length = 496 Score = 270 bits (691), Expect = 8e-73, Method: Compositional matrix adjust. Identities = 164/487 (33%), Positives = 266/487 (54%), Gaps = 12/487 (2%) Query: 51 LAGLSAALLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 108 +A ++T F+ GR++ A T V +P G+ + +A + AV AA A Sbjct: 1 MAHHHHHHMQTQLFIDGRFVDAVDRGTIDVLNPHDGSVITKIAAATAADVDLAVDAATRA 60 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWF 167 F W + A ER LL + + + N + LA++ + ++G P++++ ++ +A +F Sbjct: 61 FPAWSAMPAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRALDVPRTAACFRYF 120 Query: 168 SEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVV 227 A ++ G +I V + PIGV I PWNFP + K+G ALAAG TVV+ Sbjct: 121 GGMADKLQGSVIPVDTGFLN-YVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVL 179 Query: 228 KPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287 KP+E TP S L + EL ++ G P+GV N++P A G+ + P V KI+FTGST Sbjct: 180 KPSEITPLSTLRIVELMAEVGFPAGVVNIVPGYGHTA---GQRLAEHPGVGKIAFTGSTA 236 Query: 288 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347 TG+ ++ + ++KRV +ELGG IVFD AN+D A+ GA + F N GQ C+ ++ + Sbjct: 237 TGRRIVEASQGNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLV 296 Query: 348 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 407 + I DAF++ F A+ ++R+GN + T GPL +++ +++V V+ A +G V+ Sbjct: 297 LHERIADAFLERFV-ALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVL 355 Query: 408 TGGKRHQ---LGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 TGG Q L ++ PT++ EE FGP V++F +++EA+AIANA + Sbjct: 356 TGGSAPQDPALANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATE 415 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 523 GL ++ D ++ R+A +++ GM +N + PFGGV +SG GRE + + Sbjct: 416 YGLGSGLWTNDLSRAHRMAARIDAGMCWINCYKRVNPGSPFGGVGKSGYGREMGFEAMHD 475 Query: 524 YLELKYV 530 Y E + V Sbjct: 476 YTEARSV 482 >3IWJ-A nrPDB Length = 503 Score = 270 bits (691), Expect = 8e-73, Method: Compositional matrix adjust. Identities = 172/479 (35%), Positives = 261/479 (54%), Gaps = 16/479 (3%) Query: 64 FVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR-----WREVS 116 F+ G W PV +PA+ +G + + AV AA A R W S Sbjct: 11 FINGDWKAPVLNKRIPVINPATQNIIGDIPAATKEDVDVAVAAAKTALTRNKGADWATAS 70 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 R+ LR + + K +LA++ + + GKPL EA +I A E++++ A ++ Sbjct: 71 GAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAWDIDDVAGCFEYYADLAEKLDA 130 Query: 177 D---IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + P ++ VL++PIGV +ITPWN+P M T KV ALAAGC ++KP+E Sbjct: 131 RQKAPVSLPMDTFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAILKPSELA 190 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 + L L E+ + G+P GV N++ E G + T P V K++FTGS+ TG ++ Sbjct: 191 SLTCLELGEICKEVGLPPGVLNIL---TGLGPEAGAPLATHPDVDKVAFTGSSATGSKIM 247 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 AA VK VS+ELGG +P +VF+ ++D+A A+ F GQ C +++ ++ I Sbjct: 248 TAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHESIA 307 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR- 412 F+ + +K N+++ + EEG GP+++E EK+ K V++A S+GAT++TGG R Sbjct: 308 TEFLNRIVKWIK-NIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGGSRP 366 Query: 413 HQLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 L K FF EPT++ +VT +M EE FGP+ V F TEEEAI +AN GL Sbjct: 367 EHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGAAVI 426 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 S D + RV + + G+V VN + P+GGVK+SG GRE ++G+D YL +K V Sbjct: 427 SNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSVKQV 485 >3I44-A nrPDB Length = 497 Score = 270 bits (691), Expect = 9e-73, Method: Compositional matrix adjust. Identities = 168/497 (33%), Positives = 266/497 (53%), Gaps = 35/497 (7%) Query: 53 GLSAALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC 110 G + L + ++ G W + V DP++ A +++ R+A A+ AA +AF Sbjct: 18 GPGSMLNKRKFYINGLWDDPSTPHDLYVIDPSTEEACAVISLGSTRDADKAINAAKKAFQ 77 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPL------KEAHGEILYSAFFL 164 W+ S ER + K + + D+A+ I+ E G P+ + A G F Sbjct: 78 TWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTATGSSHIRNFIK 137 Query: 165 EW--FSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAG 222 + FS + + G+ +A++ IGV +ITPWN+P +T KV AL AG Sbjct: 138 AYKEFSFQEALIEGN--------EQAILHYDAIGVVGLITPWNWPMNQVTLKVIPALLAG 189 Query: 223 CTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 282 CT+V+KP+E P SA+ AE+ +A +PSGV+N+I N VG + P + ISF Sbjct: 190 CTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGAN---VGSYLSAHPDLEMISF 246 Query: 283 TGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC 342 TGST GK + +A+N++KRV +ELGG I+F A++D A+ + F N+GQ+C Sbjct: 247 TGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYNSGQSCNA 305 Query: 343 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK 402 + LV++ I+D +K A+ + + +VG G + G GP+++++ +K++ + + + Sbjct: 306 PTRMLVEQAIYDKAIKT-AKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSGIDE 364 Query: 403 GATVVTGGKRHQLGKN---FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 459 GAT+VTGG +G + PT+ +V M EE FGP+ ++ F+TE+EA+ +A Sbjct: 365 GATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAVTLA 424 Query: 460 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECP----FGGVKQSGLGRE 515 N + GL Y SQD ++ R+A Q+ GMV VN E P FGGVK SG RE Sbjct: 425 NDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVEVN-----GHELPGGSYFGGVKFSGRARE 479 Query: 516 GSKYGIDEYLELKYVCY 532 G +GI E+L+ K + Y Sbjct: 480 GGLWGIKEFLDTKAISY 496 >4GO4-A nrPDB Length = 495 Score = 270 bits (689), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 168/479 (35%), Positives = 268/479 (55%), Gaps = 13/479 (2%) Query: 59 LRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 ++ ++ GR++ A A T V P G+ + +A + AV AA AF W + Sbjct: 1 MQNQLYIDGRFVDAVAGGTIDVVSPHDGSLITRIAAAEAADVDLAVAAAKRAFPAWSALG 60 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175 A ER LL K + + + ++LA++ + +G P++++ G ++ +A +F A ++ Sbjct: 61 AAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACFRYFGGMADKIE 120 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G +I A V ++PIGV A I PWNFP + K+G ALAAG T+V+KP+E TP Sbjct: 121 GSVIPVDAGFLN-YVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPL 179 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 S L + EL ++ G P GV NV+P A G+A+ V KI+FTGST TG+ ++ Sbjct: 180 STLRIVELMTEVGFPKGVVNVVPGYGHTA---GQALAEHLDVGKIAFTGSTATGRRIVEA 236 Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 + +++KR+ +ELGG IVF+ AN++ AV GA + F N GQ C+ ++ ++ + I D Sbjct: 237 SKSNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQ 296 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK---R 412 F++ F A+ K++R+G+ + T GPL + ++V ++ A+ +G V+ GGK Sbjct: 297 FLERFI-ALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDD 355 Query: 413 HQLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 L F+ EPT++ QD +C EE FGP V++F ++EEA+AIAN + GL + Sbjct: 356 KALANGFYVEPTVVEAKPQDRVC-QEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLW 414 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +Q+ A+ ++A + GM +N S PFGGV QSG GRE I +Y E + V Sbjct: 415 TQNLARAHKMAHAIHAGMCWINCYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEARSV 473 >4CAZ-A nrPDB Length = 490 Score = 270 bits (689), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 164/476 (34%), Positives = 267/476 (56%), Gaps = 15/476 (3%) Query: 64 FVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERS 121 ++GGR++ A+ ATF +PA+G L V + AV++A E W ++A +RS Sbjct: 10 YIGGRYVEASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKVWAAMTAMQRS 69 Query: 122 SLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYGDIIH 180 +LR+ +++ + D+LA + T ++GKPL E +I+ A LE+++ + G+ I Sbjct: 70 RILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEGEQI- 128 Query: 181 TPAKDRR-ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 P ++ ++P+GV A I WN+P + K ALAAG ++ KP+E TP +AL Sbjct: 129 -PLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLTALK 187 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK-ILLHHAAN 298 LAE+ ++AG+P GV+NV+ S +EVG+ + PL+ KISFTG T+TGK ++ +++ Sbjct: 188 LAEIYTEAGVPDGVFNVLTGS---GREVGQWLTEHPLIEKISFTGGTSTGKKVMASASSS 244 Query: 299 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVK 358 S+K V+MELGG +P I+F A++D+A A+ + F ++GQ C + + R F Sbjct: 245 SLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQARFEA 304 Query: 359 AFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR---HQL 415 E +++ +R+G+ +E T GPL++ +E V + ++ A ++ GG+R Sbjct: 305 KVLERVQR-IRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTDGAF 363 Query: 416 GKN-FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 GK + PT+ + DM EE FGP+ ++ +D E+EAI AN + GLA +QD Sbjct: 364 GKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVVTQD 423 Query: 475 PAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 A+ R +LE G+ +N S E P GG KQSG+GRE + Y +K V Sbjct: 424 LARAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSV 479 >5AC0-A nrPDB Length = 501 Score = 267 bits (682), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 172/477 (36%), Positives = 250/477 (52%), Gaps = 12/477 (2%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 115 T F+ W + + FPV +PA+ L V + + AV+AA +AF WR + Sbjct: 21 TKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174 A ER LL K +L+ +++ LA + GK A+ L L + + A ++ Sbjct: 81 DASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKI 140 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 G I + +P+GV I PWNFP M K+G AL+ G TVVVKPAE TP Sbjct: 141 QGRTIPMDG-NFFTYTRSEPVGVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTP 199 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 +AL + L +AG P GV N++P A G AI + V K++FTGST GK++ Sbjct: 200 LTALHMGSLIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDVDKVAFTGSTEVGKLIKE 256 Query: 295 HAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 A S +KRVS+ELGG +P IVF A++D AV A F + GQ C+ +++ V+ I+ Sbjct: 257 AAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIY 316 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D FV+ E KK + +GN G +QGP I+++ EK+ + +GA + GG Sbjct: 317 DEFVRRSVERAKKYV-LGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAKLECGGGPW 375 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 F +PT+ +VT DM EE FGP+ ++KF + ++ I AN GL+ ++ Sbjct: 376 GNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTN 435 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 D + V+ L+ G V VN + S +CPFGG K SG GRE +YG EY E+K V Sbjct: 436 DIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 >1O9J-A nrPDB Length = 501 Score = 266 bits (681), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 172/480 (35%), Positives = 254/480 (52%), Gaps = 12/480 (2%) Query: 58 LLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRW 112 + T F+ W + + TFPV +PA+ + V + + AV+AA EAF W Sbjct: 18 IQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDVDKAVKAAREAFQMGSPW 77 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEA 171 R + A ER L+ K +L+ +++ LA + + +GK A+ ++ Y L + + A Sbjct: 78 RTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYLMDLDYCIKALRYCAGWA 137 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 ++ G I + + +PIGV +I PWN P ++ K+G AL G TV+VKPAE Sbjct: 138 DKIQGRTIPVDG-EFFSYTRHEPIGVCGLIFPWNAPMILLACKIGPALCCGNTVIVKPAE 196 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 TP +AL +A L +AG P GV N++P A G AI + V K++FTGST GK+ Sbjct: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDVDKVAFTGSTEVGKM 253 Query: 292 LLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 + AA S +KRV++ELG P IVF A++D AV A F N GQ+C+ +++ V+ Sbjct: 254 IQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQGQSCIAASKLFVEE 313 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I+D FV+ E KK + GN G GP IN+ K+ + + +GA + GG Sbjct: 314 AIYDEFVQRSVERAKKYV-FGNPLTPGVNHGPQINKAQHNKIMELIESGKKEGAKLECGG 372 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 F +PT+ NVT DM EE FGP+ ++KF + +E I AN GL Sbjct: 373 GPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYGLVAGV 432 Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +++D + V+ L+ G V VN L +S + P GG K SG GRE +YGI EY E+K V Sbjct: 433 FTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGEYGIHEYTEVKTV 492 >5AC2-A nrPDB Length = 501 Score = 266 bits (681), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 170/477 (35%), Positives = 253/477 (53%), Gaps = 12/477 (2%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 115 T F+ W + + FPV +PA+ L V + + AV+AA +AF WR + Sbjct: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174 A ER LL K +L+ +++ LA + + GK A+ L L + + A ++ Sbjct: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 G I + +PIGV I PWNFP M+ K+G AL+ G TVVVKPAE TP Sbjct: 141 QGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 +AL +A L +AG P GV N++P A G AI + + K++FTGST GK++ Sbjct: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDIDKVAFTGSTEVGKLIKE 256 Query: 295 HAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 A S +KRV++ELGG +P IV A++D AV A F + GQ C+ +++ V+ I+ Sbjct: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D FV+ E KK + +GN G TQGP I+++ +K+ + +GA + GG Sbjct: 317 DEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 F +PT+ NVT +M EE FGP+ ++KF + ++ I AN GL+ +++ Sbjct: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 D + ++ L+ G V VN + S +CPFGG K SG GRE +YG EY E+K V Sbjct: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 >3IWK-A nrPDB Length = 503 Score = 265 bits (677), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 166/479 (34%), Positives = 261/479 (54%), Gaps = 16/479 (3%) Query: 64 FVGGRW-LPAAAT-FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR-----WREVS 116 F+ G W +P P +P++ +G + + AV AA A R W S Sbjct: 11 FIDGEWRVPILNKRIPNINPSTENIIGDIPAATKEDVDLAVDAAKRAISRKNGRDWSAAS 70 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS---EEARR 173 R+ LR + + KD+L ++ + + GKPL+EA ++ E+++ EE Sbjct: 71 GSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEALADLDDVVACFEYYAGLAEELDS 130 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 I P ++ +LK+PIGV A+ITPWN+P M T K+ ALAAGC ++KP+E Sbjct: 131 KQKAPISLPMDTFKSYILKEPIGVVALITPWNYPFLMATWKIAPALAAGCAAILKPSELA 190 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 + L L E+ + G+P GV N++ E G ++ + P V KISFTGS+ TG ++ Sbjct: 191 SVTCLELGEICKEVGLPRGVLNIV---TGLGHEAGASLASHPDVDKISFTGSSATGSKIM 247 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 AA VK VS+ELGG +P +VF+ ++D+ + F GQ C +++ +V I Sbjct: 248 TTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEWTVFGCFFTNGQICSATSRLIVHESIA 307 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR- 412 FV + +N+++ + EEG GP+++E +KV ++ A S+GAT++TGG+R Sbjct: 308 VEFVDKLVK-WAENIKISDPLEEGCRLGPIVSEAQYKKVLNCISSAKSEGATILTGGRRP 366 Query: 413 HQLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 L K +F EPT++ +VT M EE FGP+ V F TEEEAI +AN GL Sbjct: 367 EHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFSTEEEAINLANDTHYGLGSAVM 426 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 S D + R+++ L+ G+V +N S ++ P+GG+K+SG GRE ++G++ YL +K V Sbjct: 427 SNDLERCERLSKALQAGIVWINCAQPSFIQAPWGGIKRSGFGRELGEWGLENYLSVKQV 485 >5FHZ-A nrPDB Length = 529 Score = 264 bits (675), Expect = 7e-71, Method: Compositional matrix adjust. Identities = 170/478 (35%), Positives = 253/478 (52%), Gaps = 14/478 (2%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115 T F+ W + + F +P++ + V + + AV AA AF R WR + Sbjct: 49 TKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRL 108 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174 A R LL + +L+ +++ LA + T ++GKP A L L +F+ A ++ Sbjct: 109 DALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKI 168 Query: 175 YGDIIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 G I P D + +PIGV ITPWNFP M+ K+ AL G T+V+KPAE T Sbjct: 169 QGKTI--PTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQT 226 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P +AL L L +AG P GV N++P VG AI + P ++KI+FTGST GK++ Sbjct: 227 PLTALYLGSLIKEAGFPPGVVNIVPGF---GPTVGAAISSHPQINKIAFTGSTEVGKLVK 283 Query: 294 HHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 A+ S +KRV++ELGG P IV A++D AV A F N GQ C +++ V+ + Sbjct: 284 EAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQV 343 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 + FV+ E KK VG+ F+ T QGP I++K +K+ + + +GA + GG Sbjct: 344 YSEFVRRSVEYAKKR-PVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSA 402 Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 + F +PT+ VT +M EE FGP+ P++KF + EE I AN+ D GL ++ Sbjct: 403 MEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFT 462 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 ++ + ++A LE G V +N + PFGG K SG GRE +Y + EY E+K V Sbjct: 463 KNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTV 520 >4O5H-A nrPDB Length = 511 Score = 263 bits (671), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 170/478 (35%), Positives = 250/478 (52%), Gaps = 16/478 (3%) Query: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAKE 119 +G W AA+ V +PA G + V + R+ + AV AA AF WR + Sbjct: 34 LIGAEWSDAASGRQLDVVNPADGTVIARVPEADERDVQQAVAAARRAFDAGPWRTAKTTD 93 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYGDI 178 R L+ +L+ N +LA I + ++GKP+ A G ++ +A + + A ++ G + Sbjct: 94 RERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGWATKIEGSV 153 Query: 179 I-----HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 I + P + A K+P+GV I PWNFP M K+ ALA GCTVV+KPAEDT Sbjct: 154 IDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPAEDT 213 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P SAL L EL AG P GV N++ A G A+ DP + KI+FTGST TGK + Sbjct: 214 PLSALRLGELIQAAGFPDGVVNIVTGYGHTA---GAALSRDPRIDKIAFTGSTQTGKTIG 270 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 H A +++ R+S+ELGG +P IV ++D+A G + F N GQ C ++ + + Sbjct: 271 HAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSKVF 330 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D ++ A+ + +L++G G + T GPL++ K E+V + D+ G R Sbjct: 331 DGVIERVAK-IAASLKIGPGMDPATQIGPLVSAKQRERVCGYI-DSGFGEGARAAAGGRA 388 Query: 414 QLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 G FF EPT+L + TQ M EE FGP+ + FD + A+ +AN GL +S Sbjct: 389 IDGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIWS 448 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 D + I ++ ++ G V VN + PFGG+KQSG GRE + ID+Y E K V Sbjct: 449 NDLSAIHKLVPRIAAGTVWVNCHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSV 506 >5L13-A nrPDB Length = 517 Score = 260 bits (664), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 167/474 (35%), Positives = 254/474 (53%), Gaps = 12/474 (2%) Query: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118 F+ W A + TFP +P++G + VA+ + AV+AA AF WR + A Sbjct: 40 FINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDAS 99 Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRVYGD 177 R LL + +L+ +++ LA + T ++GKP ++ L L +++ A + +G Sbjct: 100 HRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK 159 Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 I D + +P+GV I PWNFP M K+G ALA G VV+K AE TP +A Sbjct: 160 TIPIDG-DFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 218 Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 L +A L +AG P GV N++P A G AI + V K++FTGST G+++ A Sbjct: 219 LYVANLIKEAGFPPGVVNIVPGFGPTA---GAAIASHEDVDKVAFTGSTEIGRVIQVAAG 275 Query: 298 NS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 +S +KRV++ELGG +P I+ A++D AV A + F N GQ C ++ VQ I+D F Sbjct: 276 SSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEF 335 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V+ + A K+ VGN F+ T QGP ++E +K+ +N +GA ++ GG Sbjct: 336 VER-SVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR 394 Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476 F +PT+ +V M EE FGP+ ++KF T EE + AN + GLA +++D Sbjct: 395 GYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLD 454 Query: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + +++ L+ G V VN + + PFGG K SG GRE +YG+ Y E+K V Sbjct: 455 KANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTV 508 >3R31-A nrPDB Length = 517 Score = 259 bits (661), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 165/483 (34%), Positives = 255/483 (52%), Gaps = 16/483 (3%) Query: 60 RTDSFVGGRWLPAAATFPVQD--PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSA 117 + F+ G ++ P + PA+G + + A+ +A A W +S Sbjct: 14 KASHFIDGDYVEDNTGTPFESIFPATGEMIAKLHAATPAIVERAIASAKRAQKEWAAMSP 73 Query: 118 KERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEA-RRVY 175 R +L++ ++M + D L+ + T ++GKP++E + A E+F A + Sbjct: 74 MARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVADPTSGADAFEFFGGIAPSALN 133 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 GD I P A + P+GV I WN+P + K AL AG +V KP+E+TP Sbjct: 134 GDYI--PLGGDFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNAMVFKPSENTPL 191 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 AL +AE+ +AG+P G++NVI R + G + P V+K+S TGS TG+ + Sbjct: 192 GALKIAEILIEAGLPKGLFNVIQGDR----DTGPLLVNHPDVAKVSLTGSVPTGRKVAAA 247 Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 AA +K V+MELGG +P IVFD A+++ AV GAM F ++GQ C + VQ+ Sbjct: 248 AAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRVFVQKKAKAR 307 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG--KRH 413 F++ + + +G+ + T GPL+++ EKV + ++GAT++TGG + Sbjct: 308 FLENLKRRTEAMI-LGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLITGGGIPNN 366 Query: 414 QLGKN-FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 G+ + +PT+ +VT DM EE FGP+ V+ FD E+E +A ANA + GLAG ++ Sbjct: 367 VAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATEFGLAGGVFT 426 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK--YV 530 D A+ RV + LE G + +N + VE PFGG KQSG GRE S ++ Y ELK YV Sbjct: 427 ADLARAHRVVDGLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAALEHYSELKTVYV 486 Query: 531 CYG 533 G Sbjct: 487 STG 489 >1WNB-A nrPDB Length = 495 Score = 257 bits (657), Expect = 8e-69, Method: Compositional matrix adjust. Identities = 164/456 (35%), Positives = 248/456 (54%), Gaps = 7/456 (1%) Query: 77 PVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKD 136 PV +PA+G L +A+ + AAVRAA AF W + + K R+ L K +++ +N Sbjct: 41 PVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQ 100 Query: 137 DLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPI 195 A + + GKPL A + EI +F+ AR + G + +++ + P+ Sbjct: 101 VFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPL 160 Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 GV A I PWN+P M K+ ALAAG VV+KP+E TP +AL LAELA P+GV N Sbjct: 161 GVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDI-FPAGVVN 219 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIV 315 ++ K VG+ + P V +S TGS TG+ ++ H A+S+KR MELGG AP IV Sbjct: 220 IL---FGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIV 276 Query: 316 FDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFE 375 FD A+++ V G + N GQ C + + Q+GI+D V+ A+ L+ G + Sbjct: 277 FDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVA-TLKSGAPDD 335 Query: 376 EGTTQGPLINEKAVEKVEKQVNDAVSKGAT-VVTGGKRHQLGKNFFEPTLLCNVTQDMLC 434 E T GPL + +E+V K V +A + G V+TGG++ + ++ PTLL QD Sbjct: 336 ESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAI 395 Query: 435 THEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNE 494 +E FGP+ V FD EE+ + AN + GLA +++D + RV+ +L+ G VN Sbjct: 396 VQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNT 455 Query: 495 GLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + E P GG K SG G++ S YG+++Y +++V Sbjct: 456 HFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHV 491 >4QYJ-A nrPDB Length = 516 Score = 254 bits (649), Expect = 6e-68, Method: Compositional matrix adjust. Identities = 165/486 (33%), Positives = 256/486 (52%), Gaps = 16/486 (3%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEA 108 L+ + L +GG+W+ A + T V +PA+G L V D V + AAV +A Sbjct: 25 LSAIDGLRLPHQMLIGGQWVSAQSGKTLNVYNPATGDILTEVPDGDVEDVNAAVESAAAT 84 Query: 109 F--CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLE 165 WR + R +L + +L+ + D+LAR+ T +GK L + E+ SA +L Sbjct: 85 LRSDTWRRMPPSARERILLRLADLLEVHGDELARLETLNNGKLLIYSKLMEVGASAQWLR 144 Query: 166 WFSEEARRVYGDIIHT-----PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220 + + A ++ G + P RA + P+GV A I PWNFP M K+ ALA Sbjct: 145 YMAGWATKLTGSTLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNFPLLMAVWKIAPALA 204 Query: 221 AGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 280 G TVV+KPAE+TP +AL LAELA +AG+P+G NV+ + A G+A+ P V+K+ Sbjct: 205 CGNTVVLKPAEETPLTALRLAELAMEAGLPAGALNVVTGRGETA---GDALVRHPKVAKV 261 Query: 281 SFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTC 340 +FTGST G+I+ S+K VS+ELGG +P IV + +A GA A+ F N GQ C Sbjct: 262 AFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVLADCDPQEAAEGAAAAIFFNHGQVC 321 Query: 341 VCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAV 400 ++ V I++ ++ A + +++ VG+G E+G GP++++K E V + + + + Sbjct: 322 TAGSRLYVHESIYEDVIQRLA-VIGESIVVGSGLEQGVHMGPMVSKKHHENVLRHIRNGI 380 Query: 401 SKGATVVTGGKRHQLGKNFF-EPTLLCN-VTQDMLCTHEETFGPLAPVIKFDTEEEAIAI 458 GA ++ GG + FF +PT+ N +D+ +E FGP+ F E + Sbjct: 381 EDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLLSQEVFGPVLVATPFSDIAEVVNE 440 Query: 459 ANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSK 518 AN + GL ++ D + R+ ++LE G V VN + PFGG K SG+GRE Sbjct: 441 ANRSVYGLGASIWTNDLSAALRINDELEAGTVWVNTHNMVDPNLPFGGFKDSGVGREHGA 500 Query: 519 YGIDEY 524 I+ Y Sbjct: 501 AAIEHY 506 >3VZ0-A nrPDB Length = 459 Score = 254 bits (649), Expect = 6e-68, Method: Compositional matrix adjust. Identities = 154/433 (35%), Positives = 236/433 (54%), Gaps = 10/433 (2%) Query: 103 RAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF 162 RA + W+ S +R ++ + +L+ +++ A +I E GK L +A EI +A Sbjct: 35 RAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDRQHHASLIATEMGKALPDALEEIDVTAD 94 Query: 163 FLEWFSEEARRVYGDIIHTPAKDR--RALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220 L +++ A + TP K + +A ++ QP+G+ I PWNFP + R G L Sbjct: 95 ILSFYANGAEEF---LAPTPLKVKTGQAKIINQPLGIIYCIEPWNFPYYQLARVAGPNLM 151 Query: 221 AGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 280 AG V+ K A + P ALA +L AG P G Y I + E + D + + Sbjct: 152 AGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYANIFLDNDQSAE----LIKDERIRGV 207 Query: 281 SFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTC 340 + TGS G+ + A ++K+ +MELGG FIV D A++D AV A+ +F N GQ C Sbjct: 208 ALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWAVWGRFANNGQVC 267 Query: 341 VCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAV 400 + + +V ++DAF+ A+ + R+GN + TT GP+ + +A+E Q +AV Sbjct: 268 TAAKRMIVHEKVYDAFLDGLKTAITR-FRIGNPLDRDTTHGPMSSLRAMELALDQTAEAV 326 Query: 401 SKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIAN 460 GAT+V GGKR F EPT+L +V++D ++E FGP+A V K +E+ AI +AN Sbjct: 327 KGGATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKVASEQAAIDLAN 386 Query: 461 AADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYG 520 + GL G +S+D A+ +VAEQ+E GMV +N ++ E PFGG+K SG GRE S G Sbjct: 387 DSPYGLGGAVFSRDIARAEKVAEQVETGMVFINTATAAAPELPFGGIKNSGFGRELSFLG 446 Query: 521 IDEYLELKYVCYG 533 I+E++ K V G Sbjct: 447 IEEFINRKLVRIG 459 >1AG8-A nrPDB Length = 499 Score = 252 bits (643), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 166/480 (34%), Positives = 252/480 (52%), Gaps = 12/480 (2%) Query: 58 LLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVAD---CGVREARAAVRAAYEAFCRW 112 +L F+ W A + TFP +P++G + VA+ V A A RAA++ W Sbjct: 16 VLYNQIFINNEWHDAVSKKTFPTVNPSTGDVICHVAEGDKADVDRAVKAARAAFQLGSPW 75 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEA 171 R + A ER LL + +L+ +++ LA + T ++GKP ++ L L +++ A Sbjct: 76 RRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYIISYLVDLDMVLKCLRYYAGWA 135 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 + +G I D + +P+GV I PWNFP M K+G ALA G VV+K AE Sbjct: 136 DKYHGKTIPIDG-DYFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAE 194 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 TP +AL +A L +AG P GV NVIP A G AI + V K++FTGST G + Sbjct: 195 QTPLTALYVANLIKEAGFPPGVVNVIPGFGPTA---GAAIASHEDVDKVAFTGSTEVGHL 251 Query: 292 LLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 + A S +KRV++E+GG +P I+ A++D AV A + F N GQ C ++ VQ Sbjct: 252 IQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQE 311 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I+ FV+ + A K+ VGN F+ T QGP ++E +KV + +G ++ GG Sbjct: 312 DIYAEFVER-SVARAKSRVVGNPFDSRTEQGPQVDETQFKKVLGYIKSGKEEGLKLLCGG 370 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 F +PT+ ++ M EE FGP+ ++KF + EE + AN + GLA Sbjct: 371 GAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKSMEEVVGRANNSKYGLAAAV 430 Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +++D + +++ L+ G V VN + + PFGG K SG GRE +YG+ Y E+K V Sbjct: 431 FTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKLSGSGRELGEYGLQAYTEVKTV 490 >6C43-A nrPDB Length = 477 Score = 248 bits (634), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 158/455 (34%), Positives = 243/455 (53%), Gaps = 7/455 (1%) Query: 78 VQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDD 137 V +PA+G + +A+ + AAV+AA AF W + + K R+ L K + + QN + Sbjct: 24 VYNPATGEVILEIAEASPAQVDAAVQAADNAFAEWGQTTPKARAECLLKLADSIEQNALE 83 Query: 138 LARIITAESGKPLK-EAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIG 196 AR+ + GKPL + EI +F+ AR + G + +++ + PIG Sbjct: 84 FARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLSGLAAGEYLEGHTSMIRRDPIG 143 Query: 197 VAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNV 256 V A I PWN+P M K+ ALAAG VV+KP+E TP +AL LA LA P GV NV Sbjct: 144 VVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAVLAKDI-FPPGVLNV 202 Query: 257 IPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVF 316 + + VG+ + V +S TGS TG+ +L H A ++KR MELGG AP IVF Sbjct: 203 L---FGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPVIVF 259 Query: 317 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 376 D A++D G F N GQ C + + QRGI+DA V+ A+ +L++G +E Sbjct: 260 DDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVS-SLKMGAPEDE 318 Query: 377 GTTQGPLINEKAVEKVEKQVNDAVS-KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCT 435 T GPL + +++V V +A + V+TGG + + +F PTLL + Q+ Sbjct: 319 STELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADAKQEDAIV 378 Query: 436 HEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEG 495 E FGP+ + FD E++ + AN + GLA ++QD + R++ +L+ G +N Sbjct: 379 QREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYGCTWINTH 438 Query: 496 LISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + E P GG KQSG G++ S YG+++Y ++++ Sbjct: 439 FMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHI 473 >3RHD-A nrPDB Length = 486 Score = 248 bits (632), Expect = 6e-66, Method: Compositional matrix adjust. Identities = 157/475 (33%), Positives = 251/475 (52%), Gaps = 23/475 (4%) Query: 64 FVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 F+ G+W+ V +P S + + EA+ A+ A + + + +R ++ Sbjct: 3 FIDGKWI-NREDMDVINPYSLEVIKKIPALSREEAKEAIDTAEKYKEVMKNLPITKRYNI 61 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS--AFFLEWFSEEARRVYGDIIHT 181 L + + K++LA+I+ ++GKP+K+A E+ S F L F + R ++I Sbjct: 62 LMNIAKQIKEKKEELAKILAIDAGKPIKQARVEVERSIGTFKLAAFYVKEHR--DEVI-- 117 Query: 182 PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALA 241 P+ DR ++P+G+ ITP+NFP + K+ A+A G +V P+ P + LA Sbjct: 118 PSDDRLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIELA 177 Query: 242 ELASQA----GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 ++ A +P GVYN++ + + VG+ I + V+ ISFTGS+ G+++ A Sbjct: 178 KIIENALKKYNVPLGVYNLLTGA---GEVVGDEIVVNEKVNMISFTGSSKVGELITKKAG 234 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 K++++ELGG+ P IV A++++AV + F GQ C+ LV I D F+ Sbjct: 235 --FKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFI 292 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 + F K L VGN +E T GPLI+ + E VEK V A+ +G ++ GGKR K Sbjct: 293 EMFVNKAKV-LNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGKRD---K 348 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F PT+L V +D + ETF P+ P+I+ + EEE I IAN+ + GL ++ D + Sbjct: 349 ALFYPTIL-EVDRDNILCKTETFAPVIPIIRTN-EEEMIDIANSTEYGLHSAIFTNDINK 406 Query: 478 IWRVAEQLEVGMVGVNE-GLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + AE LE G V +N+ L PFGGVK+SGLGREG KY ++E +K + Sbjct: 407 SLKFAENLEFGGVVINDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTII 461 >4I8Q-A nrPDB Length = 514 Score = 247 bits (630), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 161/483 (33%), Positives = 261/483 (54%), Gaps = 18/483 (3%) Query: 60 RTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREV 115 R ++GG W P+ +PA+ +G + + AV AA +A R W Sbjct: 23 RRQLYIGGEWREPVKKNRIPIINPATEEIIGDIPAATAEDVDIAVEAARKAIARDDWGST 82 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE-----E 170 + +R+ LR +++ K LA + + +SGK L E+ ++ A E+++ + Sbjct: 83 TGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESAADMDDVAGCFEYYAGLAEALD 142 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 +RR+ ++ + ++ VL++P+GV +ITPWN+P M KV ALAAGC ++KP+ Sbjct: 143 SRRMTP--VNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPS 200 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E + L L E+ + G+PSG N++ E G + + P V KISFTGS TG Sbjct: 201 ELASITCLELGEICREIGLPSGALNIL---TGLGPEAGGPLASHPHVDKISFTGSGPTGS 257 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSA-NVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 ++ AA VK VS+ LGG +P +VFD N+D A + F NTGQ C +++ +VQ Sbjct: 258 KIMTAAAQLVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQ 317 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 I AF+ + KN+++ + EE GP+++ EKV K +++A S+GAT++ G Sbjct: 318 ENIASAFMDRLLK-WTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGATILCG 376 Query: 410 GKRHQ-LGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467 G+R Q L K ++ +PT++ +V M EE FGP+ V F TEE+AI +AN GL Sbjct: 377 GERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLG 436 Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 S+D + R + + G++ +N + E P+GG K+SG GR+ K+G++ +L + Sbjct: 437 AAVMSKDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWGLENFLNI 496 Query: 528 KYV 530 K V Sbjct: 497 KQV 499 >4YWE-A nrPDB Length = 487 Score = 243 bits (620), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 166/475 (34%), Positives = 250/475 (52%), Gaps = 13/475 (2%) Query: 64 FVGGRW-LPAA-ATFPVQDPASGAALGMVADCGVRE-ARAAVRAAYEAFCRWREVSAKER 120 F+ G W LPA T PV DP+ G +A + RA A W SA ER Sbjct: 15 FIAGEWTLPAQLETIPVVDPSDGQPFATIARGTAPDIERAVAAARDAFAGPWGAASAAER 74 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180 +L + + + ++LA I ++GKPLK+A + A + E+++ A +++G+ + Sbjct: 75 GRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAALARYFEFYAGAADKLHGETLP 134 Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240 A L +++P GV I PWN+P + R VGAALAAG VVKPAED S L + Sbjct: 135 YQAG-YTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAEDACLSVLRV 193 Query: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300 AELA++AG+P+G N++ E G A+ P + ISFTGS TGK++ AA + Sbjct: 194 AELAAEAGLPAGALNIV---TGYGHEAGAALARHPGIDHISFTGSPATGKLVTQMAAENH 250 Query: 301 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF 360 V++ELGG +P IVF A++D A+ +++ +N GQTC ++ L++R +++ V+ Sbjct: 251 VPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYEPLVERL 310 Query: 361 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK--RHQLGKN 418 A A LRVG + GPLIN K ++V ++DA G + G+ Sbjct: 311 ATAF-NGLRVGPSRAD-LDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVADAPESG 368 Query: 419 FFE-PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F++ P LL +V EE FGP+ ++F E+EA+A+AN GL +++D A+ Sbjct: 369 FYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWTRDGAR 428 Query: 478 IWRVAEQLEVGMVGVNE-GLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 R+A +L G V +N G VE PFGGV SG GRE + + LK + Sbjct: 429 QMRLARRLRAGQVFINNYGAGGGVELPFGGVGHSGHGREKGFEALYGFTALKTIA 483 >4JZ6-A nrPDB Length = 500 Score = 241 bits (614), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 153/477 (32%), Positives = 244/477 (51%), Gaps = 10/477 (2%) Query: 59 LRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 ++T F+ W+ ++ TF + P S + A+ V +A A +AA EAF W++V Sbjct: 18 MKTKLFINNAWIDSSDQQTFERKHPVSSEVMTESANATVTDAIKAAQAAEEAFKTWKDVG 77 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 ER LL K ++M ++ E G A + SA + A ++ G Sbjct: 78 PSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWAGFNVHASANVFREAASLATQIQG 137 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 + I T + ++ L+QP+G I PWN + + R + L G TVV K +E +P + Sbjct: 138 ETIPTDKAETLSMTLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPAT 197 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 + + +AG+P+GV N + S + E+ +A+ + + +I+FTGST G I+ A Sbjct: 198 HALITQCVQEAGLPAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQKA 257 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A +KR +ELGG +P IV D A+++ AV A+ F GQ C+ + + +V I D F Sbjct: 258 AQHLKRCLLELGGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADEF 317 Query: 357 VKAFAEAMKKNLRVGNGFEEGT-TQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415 V F E ++ L VG+ G GP+++ + E++ DA+ KGA VV GG + Sbjct: 318 VARFVEKTER-LSVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGG----M 372 Query: 416 GKNFFEP-TLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 + P T+L +V DM EETFGP+ VI+ E EAI IAN + GL+ + +D Sbjct: 373 AQGAVMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRD 432 Query: 475 PAQIWRVAEQLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + RV +E G V +N + + + P+GG K +G GR + IDE+ ELK++ Sbjct: 433 INRALRVGMSIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELKWL 489 >4LIH-A nrPDB Length = 504 Score = 240 bits (612), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 173/465 (37%), Positives = 263/465 (56%), Gaps = 22/465 (4%) Query: 75 TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAKERSSLLRKWYNLMI 132 TF P G L VADCG + AAV AA AF W ++ + R ++L +W LM Sbjct: 44 TFDCVSPIDGRVLAKVADCGEADVNAAVAAARRAFDAGVWAGLNPRARKAVLLRWAALMR 103 Query: 133 QNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYGDIIHTPAKDRR-ALV 190 ++ D+L+ + T ++GKP+ + ++ +A+ +EWF+E +V G++ PA LV Sbjct: 104 EHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAEAIDKVGGEV--APADHHLVGLV 161 Query: 191 LKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIP 250 ++P+GV A + PWNFP M K G ALAAG +VV+KP+E +P +A+ +A+LA +AGIP Sbjct: 162 TREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVVLKPSEKSPLTAIRVAQLAFEAGIP 221 Query: 251 SGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS-VKRVSMELGG 309 +GV+NV+P A E G+ + V I+FTGST GK+++ +AA S +KR +ELGG Sbjct: 222 AGVFNVVP----GAGEPGKLLALHRDVDCIAFTGSTAVGKLIMQYAAQSNLKRAWLELGG 277 Query: 310 LAPFIVF-DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL 368 +P IV D ++D+A A + F N G+ C ++ LV R I DAF++ A + + Sbjct: 278 KSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFIEKLVAAARAYV 337 Query: 369 RVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR--HQLGKNFFEPTLLC 426 GN + + G +++ +E+V + +G +VTGG R + G + EPT+ Sbjct: 338 P-GNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEG-RLVTGGARVNAETGGFYVEPTVF- 394 Query: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLE 486 V D EE FGP+ VI FD +EA+ IAN + GLA ++ + V+ +L Sbjct: 395 EVKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAAAVWTSNLTTAHDVSRRLR 454 Query: 487 VGMVGVN---EGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 G V VN EG + PFGG KQSG GR+ S + +++Y ELK Sbjct: 455 AGTVWVNCYDEG--GDMNFPFGGYKQSGNGRDKSLHALEKYTELK 497 >2QE0-A nrPDB Length = 475 Score = 239 bits (611), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 154/476 (32%), Positives = 248/476 (52%), Gaps = 16/476 (3%) Query: 63 SFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSS 122 ++V G W + + +PASGA LG V E +A +A WR +S ER++ Sbjct: 7 NYVNGEWKLSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKKAQPAWRALSYIERAA 66 Query: 123 LLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII--- 179 L K ++++++K+ + I++ E K K A E++ +A + + +EE R+ G+++ Sbjct: 67 YLHKVADILMRDKEKIGAILSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEGEVLEGG 126 Query: 180 --HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 +K + A+V ++P+G+ I+P+N+P + K+ AL AG + KP S Sbjct: 127 SFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISG 186 Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 L LAE ++AG+P+GV+N I E+G+ I V+ I+FTGST G+ + A Sbjct: 187 LLLAEAFAEAGLPAGVFNTITG---RGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAG 243 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 ++ + + LGG IV + A+++ +A F +GQ C + LV + D V Sbjct: 244 --MRPIMLALGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELV 301 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 + E + L +GN E+ PLI+ K+ + VE +NDA KGAT +T KR Sbjct: 302 EKIREKVLA-LTIGNP-EDDADITPLIDTKSADYVEGLINDANDKGATALTEIKREG--- 356 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 N P L VT DM EE FGP+ P+I+ + EEAI I+N ++ GL ++ D + Sbjct: 357 NLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFPR 416 Query: 478 IWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 + +AEQLEVG V +N + PF G K+SG G +G KY I+ +K V + Sbjct: 417 AFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVVF 472 >5N5S-A nrPDB Length = 515 Score = 238 bits (608), Expect = 4e-63, Method: Compositional matrix adjust. Identities = 147/422 (34%), Positives = 233/422 (55%), Gaps = 21/422 (4%) Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI 178 ER ++L K + +++A+ +T ESGKP+K+A GE+ + + +EE+ R+YG+ Sbjct: 99 ERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDARGEVTRTIDTFQVAAEESVRIYGE- 157 Query: 179 IHTP------AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 H P K + +V K PIG ++++PWNFP ++ KV A+A GC V+KPA Sbjct: 158 -HIPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASR 216 Query: 233 TPFSALALAELASQ-AGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 TP SAL L E+ + +P G ++++P SR++A + D ++FTGS G Sbjct: 217 TPLSALILGEILHKIEELPLGAFSILPVSREDA----DMFTVDERFKLLTFTGSGPIGWD 272 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSA-NVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 + A K+V MELGG AP IV D ++D + + F GQ+C+ + V Sbjct: 273 MKARAGK--KKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHE 330 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 ++D + F A+KK L++GN FEE T GP+I+E A + +E V +AV+KG ++TGG Sbjct: 331 RLYDEVKEGFVAAVKK-LKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGG 389 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 R F EPT++ +V + EE FGP+ + K+ +EA+ N GL Sbjct: 390 NRKGA---FIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGI 446 Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVEC-PFGGVKQSGLGREGSKYGIDEYLELKY 529 +++D + + E +EVG V +N+ V+ P+GG+K SG+ REG KY +D+ LE K Sbjct: 447 FTKDLNKAFYAFEHMEVGGVILNDSPALRVDSQPYGGLKDSGIQREGVKYAMDDMLETKV 506 Query: 530 VC 531 + Sbjct: 507 LV 508 >3EFV-A nrPDB Length = 462 Score = 236 bits (602), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 139/455 (30%), Positives = 244/455 (53%), Gaps = 14/455 (3%) Query: 80 DPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLA 139 +PA+G L + +E A+ A F +W+ S +R+ LR + + +++A Sbjct: 13 NPATGQTLAAMPWANAQEIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMA 72 Query: 140 RIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTP----AKDRRALVLKQPI 195 + IT E GKP+K+A E+ SA +W++E +G + P ++++A++ +P+ Sbjct: 73 QCITREMGKPIKQARAEVTKSAALCDWYAE-----HGPAMLNPEPTLVENQQAVIEYRPL 127 Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 GV I PWNFP + R L AG + ++K A + A +A + ++AG P+GVY Sbjct: 128 GVILAIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYG 187 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIV 315 + + + + + DP ++ ++ TGS G + A ++K+ +ELGG PFIV Sbjct: 188 WVNANNEGVSQ----MINDPRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIV 243 Query: 316 FDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFE 375 + A+++ AV A+A +++NTGQ C + +F+V+ GI AF F A L++G+ Sbjct: 244 LNDADLELAVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDRFVAAAAA-LKMGDPLV 302 Query: 376 EGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCT 435 E GP+ +++ +QV +V++GA ++ GG++ N++ T+L +VT DM Sbjct: 303 EENDLGPMARFDLRDELHQQVQASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAF 362 Query: 436 HEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEG 495 +E FGP+A + A+A+AN ++ GL+ ++ D +A +LE G V +N Sbjct: 363 RQELFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFINGY 422 Query: 496 LISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 S FGGVK+SG GRE S +G+ E+ ++ V Sbjct: 423 SASDARVAFGGVKKSGFGRELSHFGLHEFCNVQTV 457 >4F3X-A nrPDB Length = 498 Score = 235 bits (599), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 150/481 (31%), Positives = 243/481 (50%), Gaps = 16/481 (3%) Query: 57 ALLRTDSFVGGRWLPAA-ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 +++ T +G R+ A + +P +GA + +A+ + AAV AA AF W + Sbjct: 22 SMMDTQLLIGSRFEAGTEAEEHILNPRTGAGIIDLAEASHAQIDAAVDAAERAFVGWSQT 81 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVY 175 + ERS+ L K + + + D+ A + GKP+ + L + F A R Sbjct: 82 TPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKNDELPAIIDCWRFFAGAVRN- 140 Query: 176 GDIIHTPAKD-----RRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 +H PA +++ + PIG+ I PWN+P M+ K+ A+ G TVV KP+ Sbjct: 141 ---LHAPAAGEYLPGHTSMIRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPS 197 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E TP +AL LA L + +P GV NVI + VG A+ P V +S TG TGK Sbjct: 198 EQTPLTALKLARLIADI-LPEGVVNVIT---GRGETVGNALINHPKVGMVSITGDIATGK 253 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 +L AA +VKR +ELGG AP IV+ A+++ V G + N GQ C + + + Sbjct: 254 KVLAAAAKTVKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEA 313 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS-KGATVVTG 409 GI++ V A+ +R + GPLI+ + ++V V A K + TG Sbjct: 314 GIYEKLVADLTSAVS-TIRYNLDDDTENEIGPLISRRQRDRVASFVERAADQKHIEITTG 372 Query: 410 GKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 G+ FF+PT++ TQ+ E FGP+ V +F +++A+A AN +D GLA Sbjct: 373 GRTGSDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASS 432 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 +++D ++ R A +L+ G +N + + E P GG+KQSG G++ S Y +++Y +++ Sbjct: 433 VWTKDISKAMRAASRLQYGCTWINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRH 492 Query: 530 V 530 + Sbjct: 493 I 493 >3R64-A nrPDB Length = 508 Score = 234 bits (597), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 159/488 (32%), Positives = 256/488 (52%), Gaps = 21/488 (4%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAATFPVQD--PASGAALGMVADCGVREARAAVRAAYEA 108 AG+ A T +GG+W+ + + P + + + + AA AA +A Sbjct: 7 FAGIDA----TKHLIGGQWVEGNSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKA 62 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 168 W A ERS+++ + L+ ++++++ + ESG +A+ EI + + + Sbjct: 63 QAEWAATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLEITLAGNITKESA 122 Query: 169 EEARRVYGDII--HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVV 226 RV+G I +TP K+ R V + GV VI+PWNFP + R V ALA G VV Sbjct: 123 SFPGRVHGRISPSNTPGKENR--VYRVAKGVVGVISPWNFPLNLSIRSVAPALAVGNAVV 180 Query: 227 VKPAEDTPFSALAL-AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGS 285 +KPA DTP + + A + +AG+P+GV + + + E+G+ T + ISFTGS Sbjct: 181 IKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGA---GSEIGDHFVTHAVPKLISFTGS 237 Query: 286 TTTGKILLHHAANS--VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCS 343 T G+ + A N +K V++ELGG APF+V A++D A A F + GQ C+ Sbjct: 238 TPVGRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAVGAFLHQGQICMSI 297 Query: 344 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 403 N+ +V +HD F++ F EA+ KN+ G+ EGT GP+IN+ + +++++ A +G Sbjct: 298 NRVIVDAAVHDEFLEKFVEAV-KNIPTGDPSAEGTLVGPVINDSQLSGLKEKIELAKKEG 356 Query: 404 ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 ATV G + P + +VT DM EE FGPL V+K D E A +ANA+D Sbjct: 357 ATVQVEGP---IEGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHAAELANASD 413 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSV-ECPFGGVKQSGLGREGSKYGID 522 GL+ +S+D + + A Q++ GMV +N+ ++ FGG K SGLGR + I+ Sbjct: 414 FGLSAAVWSKDIDRAAQFALQIDSGMVHINDLTVNDEPHVMFGGSKNSGLGRFNGDWAIE 473 Query: 523 EYLELKYV 530 E+ +++ Sbjct: 474 EFTTDRWI 481 >3B4W-A nrPDB Length = 495 Score = 234 bits (597), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 155/476 (32%), Positives = 252/476 (52%), Gaps = 18/476 (3%) Query: 64 FVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSAKE 119 F+GG+W + + V+ PA+G +G V + AAV AA AF W E Sbjct: 12 FIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPHE 71 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKP---LKEAHGEILYSAFFLEWFSEEARRVYG 176 R++++ ++ + KD +++ AE+G+P ++ H + S + +F+ A +V Sbjct: 72 RAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMH--WMGSMGAMNYFAGAADKVTW 129 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 T +++V ++P+GV I WN P + K+ AL AGCT+V+KPA +TP + Sbjct: 130 TETRT-GSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLT 188 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A ALAE+ ++ G+P GV +V+P E G+A+ ++P + +FTGS+ G+ + A Sbjct: 189 ANALAEVFAEVGLPEGVLSVVP----GGIETGQALTSNPDIDMFTFTGSSAVGREVGRRA 244 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A +K ++ELGG + I+ + ++ A+ + S N GQ CV + L R +D Sbjct: 245 AEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEI 304 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ-L 415 V A + L VG + GPLI+EK +VE + + +GA +V GG R + L Sbjct: 305 VAAVTNFVTA-LPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGRPEGL 363 Query: 416 GKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 FF +PT+ +V M EE FGP+ +I +DTEE+AIAIAN + GLAG ++ D Sbjct: 364 DNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTD 423 Query: 475 PAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + ++++Q+ G G+N PFGG K SG+GRE G++ + + K V Sbjct: 424 VPKGIKISQQIRTGTYGINWYAFDP-GSPFGGYKNSGIGRENGPEGVEHFTQQKSV 478 >4DNG-A nrPDB Length = 485 Score = 223 bits (567), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 146/481 (30%), Positives = 252/481 (52%), Gaps = 26/481 (5%) Query: 63 SFVGGRWL--PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120 SF+ G+W + T + +P + + + ++ A A +A W + + ++R Sbjct: 9 SFINGKWTGGESGRTEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQKEWAKSTTEDR 68 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEW---FSEEARRVYGD 177 ++L+K + +N+DD+ +I E+G G I+ S LE +EA G+ Sbjct: 69 KAVLQKARGYLHENRDDIIMMIARETG-------GTIIKSTIELEQTIAILDEAMTYTGE 121 Query: 178 I-----IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + + + + + + + P+GV + I+P+NFP + R + A+A G +VV KP Sbjct: 122 LGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQ 181 Query: 233 TPFSA-LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 T S +A+ AG+P+GV NV+ + KE+G+ + T+P+ ISFTGST G+ Sbjct: 182 TAISGGTIIAKAFEHAGLPAGVLNVMLT---DVKEIGDGMLTNPIPRLISFTGSTAVGRH 238 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 + A + KR+++ELGG PF V A+VD+AV A+ KF + GQ C+ N+ +V + Sbjct: 239 IGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQD 298 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 ++D FV+ F A K L G+ + T GPLINE+ +EK + + A + G + GK Sbjct: 299 VYDEFVEKFT-ARVKQLPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGK 357 Query: 412 RHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 R +G N P + + E F P+A +IK +++EAI +AN + GL+ + Sbjct: 358 R--VG-NVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVF 414 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLIS-SVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + D + + A Q++ GM VN+ ++ S FGG K SG+GR G+ + ++E+ K++ Sbjct: 415 TSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGGNKASGVGRFGNPWVVEEFTVTKWI 474 Query: 531 C 531 Sbjct: 475 S 475 >3VZ3-A nrPDB Length = 457 Score = 216 bits (549), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 137/437 (31%), Positives = 214/437 (48%), Gaps = 12/437 (2%) Query: 97 EARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGE 156 E A + A EAF +R S +R L ++ ++ A I+T E GK + A E Sbjct: 27 EIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAEIMTTEMGKTHQSAIAE 86 Query: 157 ILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVG 216 SA +++E + + +T + + V QP+G+ + PWNFP + R Sbjct: 87 AEKSALVCRYYAEHGEQFLANE-YTETQATESYVCYQPLGILLAVMPWNFPFWQVFRFAA 145 Query: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 276 AL AG V+K A + P ALA+ + AG P GV+ + A +V E + DP Sbjct: 146 PALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLI---GASQV-EQVIKDPR 201 Query: 277 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 336 V + TGS G L A +K +ELGG PF+VF SA++D+AV ++ N Sbjct: 202 VKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAVEVGTVARTMNN 261 Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMK---KNLRVGNGFEEGTTQGPLINEKAVEKVE 393 GQ+ + + +F+ +H+A F E + +L++G+ T GPL E ++ + Sbjct: 262 GQSAIAAKRFI----LHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPLATEGILQDIS 317 Query: 394 KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEE 453 +QV+ AV+ GA ++ GG+ F+ PT+L + EE F P+A V + Sbjct: 318 RQVDQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEELFAPVAMVFTVKDLD 377 Query: 454 EAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLG 513 +AIA+AN GL ++ DPA+ R ++L+ G V +N + S PFGG K+SG G Sbjct: 378 QAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVKSDPRLPFGGTKRSGYG 437 Query: 514 REGSKYGIDEYLELKYV 530 RE GI ++ K V Sbjct: 438 RELGLAGIRTFVNAKTV 454 >5JRY-A nrPDB Length = 485 Score = 215 bits (548), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 148/431 (34%), Positives = 227/431 (52%), Gaps = 19/431 (4%) Query: 104 AAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFF 163 AA +A RE+ A +R ++L + D+LA + E+GKP+ +A GE+ Sbjct: 57 AAVDATKPMRELPAYKRQAVLDHCVARFRERFDELAEALCIEAGKPINDAKGEVTRLIDT 116 Query: 164 LEWFSEEARRVYGDIIHTPAKDR----RALVLKQPIGVAAVITPWNFPSAMITRKVGAAL 219 SEEA R+ G++++ R + PIG + I+P+NFP + KV AL Sbjct: 117 FRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPAL 176 Query: 220 AAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSK 279 AAGC V+KPA TP AL + E+ ++ +P G ++V+P R A + TD Sbjct: 177 AAGCPFVLKPASRTPVGALIIGEVLAETDLPKGAFSVLPAHRDGA----DLFTTDDRFRL 232 Query: 280 ISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQA--VAGAMA-SKFRNT 336 +SFTGS G L A K+V +ELGG A IV D+ +D+ V +A F + Sbjct: 233 LSFTGSPAVGWALKEKAGK--KKVVLELGGNAAAIV-DADQLDRLDYVVDRLAFGAFYQS 289 Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQV 396 GQ+C+ + L I+DA A ++L++G+ + T GP+I+E ++ + Sbjct: 290 GQSCIGVQRILAHADIYDALRDKLI-AKTRSLKMGDPKDPSTFVGPMISESESRRLSGWM 348 Query: 397 NDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAI 456 + AV+ GA +V GGK + FE TLL NV +D +E FGP+A + KFD ++A+ Sbjct: 349 DAAVAAGAKIVAGGK---VDGAMFEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDAL 405 Query: 457 AIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGRE 515 A N +D GL ++ A + ++LEVG V +N+ V+ P+GGVK SGLGRE Sbjct: 406 ARVNDSDFGLQAGVFTDSLAHTQQAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGRE 465 Query: 516 GSKYGIDEYLE 526 G +Y I++ E Sbjct: 466 GIRYAIEDMTE 476 >6MVR-A nrPDB Length = 767 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 153/464 (32%), Positives = 232/464 (50%), Gaps = 28/464 (6%) Query: 64 FVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 F+GG W F +PA+G L V+ + AAV+AA +A W + A R+ + Sbjct: 36 FIGGAWTAPGDLFATVNPATGQTLAQVSQATQADVDAAVKAARKAQPAWAKDGAA-RARV 94 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPA 183 L L+ ++ A + T ++GKP++EA + F A Y ++ T Sbjct: 95 LYALARLLQKHARLFAVLETLDNGKPIREARD--IDVPLAQRHFYHHAG--YAQLMGTEM 150 Query: 184 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL 243 DR P+GV + PWNFP M+ K+ ALA G TVV+KPAE TP +AL A++ Sbjct: 151 PDR------APLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTALLFADI 204 Query: 244 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRV 303 QAG+P+GV N++ VGE I T V K++FTGST G+ + A + K + Sbjct: 205 CGQAGVPAGVVNIV----TGDGAVGEMIVT-AQVDKVAFTGSTAVGRRIREATAGTGKAL 259 Query: 304 SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEA 363 S+ELGG P++V D A++D AV G + + + N GQ C ++ LVQ GI D F A A Sbjct: 260 SLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVF-HAKLRA 318 Query: 364 MKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN---FF 420 +LR+G+ ++ G +++ + +V V T G+ +Q ++ Sbjct: 319 RMDSLRIGDPLDKCIDIGAMVHPDQLARVRDMV--------AANTDGEVYQTAVPAGCYY 370 Query: 421 EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR 480 PTL+ + +E FGP+ F T EA+ IAN GLA +S++ Sbjct: 371 PPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAASVWSENVNLALD 430 Query: 481 VAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEY 524 +A +L G+V +N + PFGGV++SG GREG G+ Y Sbjct: 431 LAPKLVAGIVWINGTNMMDAAAPFGGVRESGFGREGGWEGLAGY 474 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 76/183 (41%), Gaps = 5/183 (2%) Query: 84 GAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIIT 143 G LG + ++ R AV A A W + R+ +L + D+ A I Sbjct: 527 GKLLGHASLSNRKDLRNAVEA-MNAASGWSRTTGHLRAQILYFIGENLSARADEFANRIK 585 Query: 144 AESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITP 203 +GK + E+ S L + A + G + P + AL +K+P+G ++ P Sbjct: 586 DMTGK---DGKAEVAASIDRLFSAAAWADKYDGQVKGVPLRGV-ALAMKEPVGKIGILCP 641 Query: 204 WNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKN 263 P + + A+A G V + +E P +A ++ + +P+GV N++ + + Sbjct: 642 DAAPLLGLVSLMAPAIAMGNRVTLAASEAFPLAATDFYQVLDTSDVPAGVVNILTGAHAD 701 Query: 264 AKE 266 E Sbjct: 702 LAE 704 >3PRL-A nrPDB Length = 505 Score = 213 bits (542), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 151/471 (32%), Positives = 241/471 (51%), Gaps = 19/471 (4%) Query: 54 LSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 +A +LR +V R + PASG ALG + E A++ A +A W+ Sbjct: 10 FNANILRNGEWVESR---TGERISISAPASGVALGSIPALSQEEVNDAIQGAKDAQKIWK 66 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 ER LL W +L+ + K+ + +I E KP K A GE+ +A + ++EA R Sbjct: 67 IRPIHERVDLLYAWADLLEERKEIIGELIMHEVAKPKKSAIGEVSRTADIIRHTADEALR 126 Query: 174 VYGDIIHTP-----AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 + G+ + + + ALV ++P+GV I+P+N+P + K+ AL G TVV K Sbjct: 127 LNGETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVNLAAAKIAPALVTGNTVVFK 186 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 PA S + + E + AG P G+ V+ R + +G+ + P + I+FTG TTT Sbjct: 187 PATQGSLSGIKMVEALADAGAPEGIIQVV-TGRGSV--IGDHLVEHPGIDMITFTGGTTT 243 Query: 289 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348 G+ + A + V +ELGG P IV D A++ + ++ F +GQ C + V Sbjct: 244 GERISEKA--KMIPVVLELGGKDPAIVLDDADLKLTASQIVSGAFSYSGQRCTAIKRVFV 301 Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 Q + D V E +++ L VG+ E+ P+I+EK+ ++ ++DA+ GAT+++ Sbjct: 302 QDSVADQLVANIKELVEQ-LTVGSP-EDDADITPVIDEKSAAFIQGLIDDALENGATLLS 359 Query: 409 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 G KR N PTLL +VT M EE FGP+ P+I+ EAI+++N +D GL Sbjct: 360 GNKRQ---GNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAISLSNQSDYGLQA 416 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSK 518 +++D + + + LEVG V +N + PF GVK+SGLG +G K Sbjct: 417 SIFTKDTDRAINIGKHLEVGTVHINAKTERGPDHFPFLGVKKSGLGVQGIK 467 >1T90-A nrPDB Length = 486 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 142/482 (29%), Positives = 235/482 (48%), Gaps = 11/482 (2%) Query: 56 AALLRTDSFVGGRWLPAAATF--PVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 A + + +++ G W+ + V +PA+ L V + A + A EAF W Sbjct: 1 AEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKTWS 60 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 +V+ R+ +L + L+ Q+K++LA +IT E+GK KEA GE+ +E+ + Sbjct: 61 KVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSL 120 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + GD + + A D A + PIGV I P+NFP + A+A G T ++KP+E T Sbjct: 121 MMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERT 180 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P L EL +AG+P GV+NV+ A +V I P + ISF GS G+ + Sbjct: 181 PLLTEKLVELFEKAGLPKGVFNVV----YGAHDVVNGILEHPEIKAISFVGSKPVGEYVY 236 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 + ++KRV G IV + AN++ V + + F + G+ C+ V+ GI Sbjct: 237 KKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIA 296 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D F+ E + ++++GNG ++G GP+I E ++ + + +GA +V G+ + Sbjct: 297 DEFMAKLQEKV-ADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGREN 355 Query: 414 QLGKNFFE-PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 +F PT+ NVT +M +E F P+ VI+ +EAI IAN ++ ++ Sbjct: 356 VSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFT 415 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLG--REGSKYGIDEYLELKY 529 + I E ++ GM+G+N G+ + + PF G K S G K +D Y K Sbjct: 416 SNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKV 475 Query: 530 VC 531 V Sbjct: 476 VT 477 >3QAN-A nrPDB Length = 538 Score = 212 bits (540), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 141/451 (31%), Positives = 228/451 (50%), Gaps = 20/451 (4%) Query: 87 LGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAES 146 +G V+ A A+++A EAF WR V+ +ER+++L K ++ + K + + + E+ Sbjct: 65 VGSVSKANQDLAEKAIQSADEAFQTWRNVNPEERANILVKAAAIIRRRKHEFSAWLVHEA 124 Query: 147 GKPLKEAHGEILYSAFFLEWFSEEARRVY--GDIIHTPAKDRRALVLKQPIGVAAVITPW 204 GKP KEA + + FLE+++ + + +I+ P + R P+GV I+PW Sbjct: 125 GKPWKEADADTAEAIDFLEYYARQMIELNRGKEILSRPGEQNRYFY--TPMGVTVTISPW 182 Query: 205 NFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNA 264 NF A++ A + G TVV+KPA TP A E+ AG+P GV N +P S Sbjct: 183 NFALAIMVGTAVAPIVTGNTVVLKPASTTPVVAAKFVEVLEDAGLPKGVINYVPGS---G 239 Query: 265 KEVGEAICTDPLVSKISFTGSTTTGKILLHHAA------NSVKRVSMELGGLAPFIVFDS 318 EVG+ + P S I+FTGS G L AA N +KRV +E+GG +V Sbjct: 240 AEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGGKDTVVVDRD 299 Query: 319 ANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGT 378 A++D A + S F +GQ C ++ ++ + ++D ++ A+ KNL VG+ Sbjct: 300 ADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDVYDEVLEKTV-ALAKNLTVGDPTNRDN 358 Query: 379 TQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEE 438 GP+I+EKA EK+ + +G ++TGG+ F +PT++ ++ + + EE Sbjct: 359 YMGPVIDEKAFEKIMSYIEIGKKEG-RLMTGGEGDSSTGFFIQPTIIADLDPEAVIMQEE 417 Query: 439 TFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLIS 498 FGP+ K + + A+ IAN + GL G +++ A I + + VG + N Sbjct: 418 IFGPVVAFSKANDFDHALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGNLYFNRNCTG 477 Query: 499 SV--ECPFGGVKQSGLGREGSKYGIDEYLEL 527 ++ PFGG K SG SK G +YL L Sbjct: 478 AIVGYHPFGGFKMSGT---DSKAGGPDYLAL 505 >5KF0-A nrPDB Length = 485 Score = 211 bits (536), Expect = 8e-55, Method: Compositional matrix adjust. Identities = 145/434 (33%), Positives = 226/434 (52%), Gaps = 25/434 (5%) Query: 104 AAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFF 163 AA +A RE+ A R ++L + D+LA + E+GKP+ ++ GE+ Sbjct: 57 AAVDAVKPMRELPAYRRQAVLDHCVARFRERFDELAEALCIEAGKPINDSRGEVTRLIDT 116 Query: 164 LEWFSEEARRVYGDI----IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAAL 219 SEEA R+ G++ I A+ + PIG + I+P+NFP + KV AL Sbjct: 117 FRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPAL 176 Query: 220 AAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSK 279 AAGC V+KPA TP AL +AE+ ++ +P G ++V+P R A + TD Sbjct: 177 AAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGA----DLFTTDERFRL 232 Query: 280 ISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIV----FDSAN--VDQAVAGAMASKF 333 +SFTGS G L A K+V +ELGG A IV F+ + VD+ GA + Sbjct: 233 LSFTGSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQFEQLDYVVDRLAFGA----Y 286 Query: 334 RNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVE 393 +GQ+C+ + LV ++D A ++L++G+ + T GP+I+E ++ Sbjct: 287 YQSGQSCIGVQRILVHASLYDTLRDKLV-AKTRSLKMGDPKDPSTFVGPMISESESRRLS 345 Query: 394 KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEE 453 ++ AV+ GA ++ GGK + FE TLL +V ++ +E FGP+A + KFD + Sbjct: 346 GWMDAAVAAGAKIIAGGK---VDGAMFEATLLEDVGREQDLYRKEAFGPVAILEKFDRFD 402 Query: 454 EAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGL 512 +A+A N +D GL ++ R ++LEVG V +N+ V+ P+GGVK SGL Sbjct: 403 DALARVNDSDFGLQAGVFTDSLTHAQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGL 462 Query: 513 GREGSKYGIDEYLE 526 GREG +Y I++ E Sbjct: 463 GREGIRYAIEDMTE 476 >4OGD-A nrPDB Length = 465 Score = 210 bits (535), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 135/424 (31%), Positives = 212/424 (50%), Gaps = 11/424 (2%) Query: 105 AYEAFCRWR-EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFF 163 A+ + +WR E +ER + L + N++ +++D A I+T + GK EA GE+ A Sbjct: 32 AHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGKLFTEAQGEVDLCADI 91 Query: 164 LEWFSEEARRVYGDIIHTPAKDR--RALVLKQPIGVAAVITPWNFPSAMITRKVGAALAA 221 ++++++A ++ TP + +A LKQ GV + PWNFP I R Sbjct: 92 ADYYADKADEF---LMSTPLETDSGQAYYLKQSTGVILAVEPWNFPYYQIMRVFAPNFIV 148 Query: 222 GCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKIS 281 G +V+K A P SA + EL +AG +G + S +V D V + Sbjct: 149 GNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFISYDQVSQV----IADKRVVGVC 204 Query: 282 FTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCV 341 TGS G + A ++K+ ++ELGG FI+ D A+ DQ S+ N GQ C Sbjct: 205 LTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNAGQVCT 264 Query: 342 CSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS 401 S +F+V +D F K + K + G+ + TT PL + +A V Q+ A+ Sbjct: 265 SSKRFIVLDKDYDRF-KELLTKVFKTAKWGDPMDPETTLAPLSSAQAKADVLDQIKLALD 323 Query: 402 KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANA 461 GA +V GG+ +F PT++ +T+D ++E FGP+ + K +EEEAI +AN Sbjct: 324 HGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIEVAND 383 Query: 462 ADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGI 521 ++ GL G +S + VA ++E GM +N G S E PFGG+K SG GRE S+ G Sbjct: 384 SNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWTSLPELPFGGIKHSGYGRELSELGF 443 Query: 522 DEYL 525 ++ Sbjct: 444 TSFV 447 >5UR2-A nrPDB Length = 984 Score = 207 bits (526), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 143/444 (32%), Positives = 224/444 (50%), Gaps = 51/444 (11%) Query: 108 AFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWF 167 A+ W+ V ++R++L+ K ++M +++ L E GKP EA G+I + F ++ Sbjct: 545 AYKTWKNVPCEQRAALVDKLADIMTRDRFKLIATQVLEVGKPWAEADGDIGEAIDFCRYY 604 Query: 168 SEEARRVY---------GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAA 218 + R + G++ H K R GV AVI PWNFP A++ V AA Sbjct: 605 ARHMRELQKPLRVGGLPGELSHYIYKSR---------GVTAVIAPWNFPLAILAGMVTAA 655 Query: 219 LAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVS 278 AG TVV+KPAE + A L ++ +AG P GV N +P +EVGE I + Sbjct: 656 AVAGNTVVMKPAEQSTVVAWGLMKMIQEAGFPQGVINFLPGY---GEEVGEYIVNHKYTT 712 Query: 279 KISFTGSTTTGKILLHHAA------NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASK 332 I+FTGS G +++ AA VKR +E+GG I+ + A++D+AV G + S Sbjct: 713 TIAFTGSKAVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSA 772 Query: 333 FRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKV 392 F +GQ C +++ +V ++D FV E K++ + GP+++++A +++ Sbjct: 773 FGFSGQKCSAASRVIVLDEVYDRFVDRLVET-AKSIEIHPAENPKAYMGPVVDKEAYDRI 831 Query: 393 EKQVNDAVSKGATVVTGGKRHQL-------GKNFF-EPTLLCNVTQDMLCTHEETFGPLA 444 T+ K H+L G FF PT+ +V D E FGP+ Sbjct: 832 L----------GTIAEAEKNHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLAQAEIFGPVV 881 Query: 445 PVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSV--EC 502 VI+ ++A+ IAN+ + L G +S+ PA I RV E+LEVG + VN G+ ++ Sbjct: 882 AVIRAKNLDQALDIANSTEYALTGGVFSRSPANINRVKEELEVGNLYVNRGITGAMVDRH 941 Query: 503 PFGGVKQSGLGREGSKYGIDEYLE 526 PFGG K SG+ GSK G +YL+ Sbjct: 942 PFGGFKMSGI---GSKTGGPDYLK 962 >3ROS-A nrPDB Length = 484 Score = 206 bits (524), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 133/447 (29%), Positives = 214/447 (47%), Gaps = 16/447 (3%) Query: 80 DPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLA 139 +P + A + ++ A+ A+ + +WR R+ +L N + +++D+LA Sbjct: 10 NPYTNEAFASYDNPTSKQIDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHEDELA 69 Query: 140 RIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDR----RALVLKQPI 195 +++T E GK L E+ E+ ++++ +G + P K A LKQ Sbjct: 70 KMMTLEMGKLLSESKEEVELCVSICNYYAD-----HGPEMLKPTKLNSDLGNAYYLKQST 124 Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSG-VY 254 GV PWNFP + R G +++K A + P SA A++ +AG P G + Sbjct: 125 GVIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLI 184 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFI 314 N+ P + A I DP + ++ TGS G + A ++K+ +MELGG FI Sbjct: 185 NLYPSYDQLAD-----IIADPRIQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFI 239 Query: 315 VFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGF 374 V D A+ ++ N GQ C S + +V++ +D + NL+ G+ Sbjct: 240 VLDDADPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFS-NLKAGDPL 298 Query: 375 EEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 434 E TT P+ +EKA EK+E QV +A+ GA V FF PT+L ++ +D Sbjct: 299 EADTTLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNPV 358 Query: 435 THEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNE 494 +E FGP+A V + + AI +AN + GL D + +V+ Q+E GM +N Sbjct: 359 FDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVING 418 Query: 495 GLISSVECPFGGVKQSGLGREGSKYGI 521 I+S E PFGG+K+SG GRE S G+ Sbjct: 419 RWITSGELPFGGIKKSGYGRELSGLGL 445 >6FK3-A nrPDB Length = 536 Score = 206 bits (523), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 140/443 (31%), Positives = 216/443 (48%), Gaps = 20/443 (4%) Query: 99 RAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEIL 158 R A A EAF W A R +L ++ + K L R++ E GK KEA G++ Sbjct: 59 RKAALKAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEAAGDVQ 118 Query: 159 YSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAA 218 + +F+ E RR+YG + + +D+ ++P+GV +IT NFP A+ + K+ A Sbjct: 119 EAIDTALFFASEGRRLYGQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPSWKLIPA 178 Query: 219 LAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAK-EVGEAICTDPLV 277 + G TVV KP+ED P + A+L +AG+P GV NV+ K + + + + L Sbjct: 179 VLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELMDEGLF 238 Query: 278 SKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTG 337 K +FTGST G+ + A ++ R ++ELGG P +V A++D AV GA S F G Sbjct: 239 QKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSAFATGG 298 Query: 338 QTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNG-FEEGTTQGPLINEKAVEKVEKQV 396 Q C + LV I++ F + F E ++ L VGN T GP INE+ + ++ Sbjct: 299 QRCTSAGNILVDAPIYEEFKRRFLERVEATL-VGNPLLHPEVTYGPFINERFFARWQEHY 357 Query: 397 NDAVSKGATVVTGGKRHQLGKNFFEPTLLCN-------------VTQDMLCTHEETFGPL 443 ++GA ++ G R ++ + P L + V EE FGP Sbjct: 358 RVGEAEGARLLFG--RGRITRENPYPRFLGDPEAGLYGWPTVWEVRPGTRLFTEEVFGPT 415 Query: 444 APVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLI-SSVEC 502 ++K D EEAIA+AN+ GL+ Y+ + + GM +N + + Sbjct: 416 INLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGAEAHL 475 Query: 503 PFGGVKQSGL-GREGSKYGIDEY 524 PFGGVK SG GRE + ++EY Sbjct: 476 PFGGVKASGNGGRESGIWVLEEY 498 >1UXV-A nrPDB Length = 501 Score = 197 bits (500), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 141/480 (29%), Positives = 229/480 (47%), Gaps = 20/480 (4%) Query: 63 SFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRW--REVSAKER 120 S++ G W + V+ P A + V E + ++ RW R++ ER Sbjct: 21 SYLAGEWGGSGQEIEVKSPIDLATIAKVISPSREEVERTLDVLFKR-GRWSARDMPGTER 79 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII- 179 ++LRK +++ +N D A ++ +GKP A GE+ + L + +++ GD I Sbjct: 80 LAVLRKAADIIERNLDVFAEVLVMNAGKPKSAAVGEVKAAVDRLRLAELDLKKIGGDYIP 139 Query: 180 ---HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 + LV ++P+GV A ITP+N+P K+ + G VVVKP+ P Sbjct: 140 GDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSISDPLP 199 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A + AG P ++ K A E I D V+ +SFTGST G+ ++ Sbjct: 200 AAMAVKALLDAGFPPDAIALLNLPGKEA----EKIVADDRVAAVSFTGSTEVGERVVK-- 253 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 VK+ MELGG P IV + A++D A + GQ C L +R ++ Sbjct: 254 VGGVKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKL 313 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V+ A+ + +LRVG+ + GPLI+ AV+++ + DAV KG V+ GG+R LG Sbjct: 314 VEEVAKRL-SSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRR--LG 370 Query: 417 KNFFEPTLL---CNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + +PTL+ + +DM+ E F P+A ++ ++AI +AN GL + + Sbjct: 371 PTYVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVFGR 430 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSV-ECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 D +I R LEVG + +N+ + PFGG K+SG+ REG Y ++ K + + Sbjct: 431 DVVKIRRAVRLLEVGAIYINDMPRHGIGYYPFGGRKKSGVFREGIGYAVEAVTAYKTIVF 490 >5J6B-A nrPDB Length = 485 Score = 196 bits (499), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 135/426 (31%), Positives = 219/426 (51%), Gaps = 17/426 (3%) Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR 172 R + A R ++L + D+LA+ + E+GKP+ ++ GE+ +EE+ Sbjct: 66 RALPAFRRQAILEHCVARFRERFDELAQALCIEAGKPINDSKGEVTRLIDTFRVAAEESV 125 Query: 173 RVYGDIIHTPAKDR----RALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 R+ G +++ R + PIG + I+P+NFP + KV ALAAGC V+K Sbjct: 126 RIEGGLVNLEISPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLK 185 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 PA TP AL + E+ ++ +P G ++++P R A + TD +SFTGS T Sbjct: 186 PASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGA----DLFTTDERFKLLSFTGSPTV 241 Query: 289 GKILLHHAANSVKRVSMELGGLAPFIV-FDSANVDQAVAGAMA-SKFRNTGQTCVCSNQF 346 G L K+V +ELGG A IV D V V +A + +GQ+C+ + Sbjct: 242 GWEL--KKKAGKKKVVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRI 299 Query: 347 LVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATV 406 + ++DA + A ++L++G+ + T GP+I+E ++ + AV+ GA + Sbjct: 300 IAHADVYDALREKLI-AKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKI 358 Query: 407 VTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGL 466 V GGK + FE TLL V +D +E FGP+A + +F ++A+A N +D GL Sbjct: 359 VAGGK---VDGAMFEATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGL 415 Query: 467 AGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYL 525 ++ + R ++LEVG V +N+ V+ P+GGVK SGLGREG +Y I++ Sbjct: 416 QAGVFTDSLSHAQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMT 475 Query: 526 ELKYVC 531 EL+ + Sbjct: 476 ELRLMV 481 >2JG7-A nrPDB Length = 510 Score = 190 bits (482), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 129/467 (27%), Positives = 222/467 (47%), Gaps = 14/467 (2%) Query: 67 GRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRK 126 G W + PA+ + V + E V+ EA+ W ++ A +R ++R+ Sbjct: 28 GSWGGSGEVITSYCPANNEPIARVTQATLAEYEETVQKTREAWKMWADIPAPKRGEIVRQ 87 Query: 127 WYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDR 186 + + + L +++ E GK E GE+ ++ +R + G ++ + Sbjct: 88 IGDALRKKIKVLGSLVSLEMGKIYVEGVGEVQEYVDVCDYAVGLSRMIGGPVLPSERPGH 147 Query: 187 RALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL----AE 242 + P+G+ +IT +NFP A+ AL G + K A TP +++A+ AE Sbjct: 148 ALIEQWNPVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAE 207 Query: 243 LASQAGIPSGVYNVIPCSRK-NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVK 301 + Q +P + CS ++G A+ D V +SFTGST GK++ Sbjct: 208 VLEQNNLPGAI-----CSMTCGGADIGTAMAKDERVDLLSFTGSTHVGKMVAMMVQERFG 262 Query: 302 RVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFA 361 R +ELGG IVF+ A+++ V A+ + GQ C + + ++ +HDA V+ A Sbjct: 263 RKLLELGGNNAIIVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVVERIA 322 Query: 362 EAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFE 421 +A K+ +R+G+ ++ T GPL ++AV++ + A +G T+V GGK N+ E Sbjct: 323 KAYKQ-VRIGDPWDPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMDRPGNYVE 381 Query: 422 PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI--W 479 PT++ + D H ETF P+ V+KF TEEEA A N GL+ +++D ++ W Sbjct: 382 PTIITGLAHDAPIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRVFRW 441 Query: 480 RVAEQLEVGMVGVNEGLI-SSVECPFGGVKQSGLGREGSKYGIDEYL 525 + + G+V VN + + FGG K +G GRE +Y+ Sbjct: 442 LGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYM 488 >4PXN-A nrPDB Length = 525 Score = 189 bits (480), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 133/480 (27%), Positives = 221/480 (46%), Gaps = 9/480 (1%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC 110 LA L A +F G W + T P + + V + V + +RA ++A Sbjct: 28 LAELGLAQRNPGAFACGAWGGSGPTVTSTSPTNNQVIAEVVEASVHDYEEGMRACFDAAK 87 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEE 170 W + A +R ++R+ + + L R+++ E GK L E GE+ ++ Sbjct: 88 TWMAIPAPKRGEIVRQIGDALRAKLHHLGRLVSLEMGKILPEGIGEVQEIIDMCDYAVGL 147 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 +R++ G II + + + + P+GV VIT +NFP A++ AL G VV K A Sbjct: 148 SRQLNGSIIPSERPNHMMMEVWNPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGA 207 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 TP +A+ ++ + + + I S E+G+AI D + +SFTGST G Sbjct: 208 PTTPLITIAMTKIVASVLEKNNLPGAIFTSFCGGTEIGQAIALDIRIPLVSFTGSTRAGL 267 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 ++ + + +EL G IV D A++ AV + + GQ C + ++ Sbjct: 268 MVQQQVSARFGKCLLELSGNNAIIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHE 327 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I+ F+ E K+ +R+G+ E+GT GPL + E K + S+G ++ GG Sbjct: 328 NIYQTFLDQLVEVYKQ-VRIGDPLEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGG 386 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 + NF +PT++ +T EE FGP+ V+KF T +EAI I N+ GL+ Sbjct: 387 SAIESEGNFVQPTIV-EITPSAPVVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSI 445 Query: 471 YSQDPAQI--WRVAEQLEVGMVGVN---EGLISSVECPFGGVKQSGLGREGSKYGIDEYL 525 +++ P I W + G+V VN G + + FGG K +G GRE +Y+ Sbjct: 446 FTKRPDIIFKWLGPHGSDCGIVNVNIPTNG--AEIGGAFGGEKATGGGREAGSDSWKQYM 503 >5U0M-A nrPDB Length = 497 Score = 186 bits (473), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 139/474 (29%), Positives = 225/474 (47%), Gaps = 19/474 (4%) Query: 57 ALLRTDSFVGGRWLPA-AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 A L + ++ G WLP A F P +G + + + AAVR A +AF WR Sbjct: 8 ANLTGNVYIDGLWLPGHGAPFESVQPVTGETVWDGNAASLEDVDAAVREARKAFLAWRRK 67 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSA----FFLEWFSEEA 171 S ER +++ + L+ NK++LA I E+GKPL E+ E+ ++ ++E Sbjct: 68 SLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESRTEVAAMMGKIPISVKAYNERT 127 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 D+ A++ +P GV AV P+NFP + + AL AG TVV KP+E Sbjct: 128 GHTESDV-----AGGHAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSE 182 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 TP A L +AG+P GV N++ + + G+ + L+ + FTGS+T G + Sbjct: 183 LTPGVAELTVRLWEKAGLPDGVINLV----QGGSDTGKCLARHSLIDGLFFTGSSTVGHL 238 Query: 292 LLHHAANSVKRV-SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 L +++ ++E+GG P IV + +++D AV A+ S F + GQ C C+ + LV + Sbjct: 239 LHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAFLSAGQRCTCARRLLVPK 298 Query: 351 GIH-DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 G D F+ E + + G +I+ +A ++ K + KGAT + Sbjct: 299 GKKGDEFLARLVEVAARITVAEFDADPQPFMGSVISAEAANQLLKAQAAMLEKGATSLLE 358 Query: 410 GKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 K+ + P ++ ++ +E FGPL V ++ +EA+ +AN GL+ Sbjct: 359 MKQLKPDTGLLSPGIVDATGIEL--EDQEFFGPLLTVYRYKGFDEALELANNTRYGLSAG 416 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLI-SSVECPFGGVKQSGLGREGSKYGID 522 S D R+ E++ G+V N L +S PFGGV SG R + Y D Sbjct: 417 ILSDDRKLYNRLVEEVRAGIVNWNRPLTGASSAAPFGGVGASGNHRPSAYYAAD 470 >5TJR-A nrPDB Length = 531 Score = 186 bits (471), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 136/454 (29%), Positives = 225/454 (49%), Gaps = 12/454 (2%) Query: 75 TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQN 134 T V +P++G A+ V + A+ AA AF WR +R+ +L ++ L+ N Sbjct: 52 TADVFNPSTGEAVRKVPLADRETMQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEAN 111 Query: 135 KDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194 ++ + ++I+ E GK +++A GE+ +E+ + + G+ + A QP Sbjct: 112 EERIVKLISEEHGKTIEDAAGELKRGIENVEYATAAPEILKGEYSRNVGPNIDAWSDFQP 171 Query: 195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVY 254 IGV A ITP+NFP+ + A+A G T ++KP+E P S L +AEL +AG+P GV Sbjct: 172 IGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVL 231 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFI 314 NV+ K +A+ P V +SF GST + + KRV G + Sbjct: 232 NVV----HGDKGAVDALIEAPEVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAV 287 Query: 315 VFDSANVDQAVAGAMASKFRNTGQTCVC-SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNG 373 + A++D AV+ M + + + G+ C+ S V I DA V+ + K L++G G Sbjct: 288 LMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQIADALVQKLVPQI-KGLKIGAG 346 Query: 374 FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN----FFEPTLLCNVT 429 G GPL+ A +KV ++ V++GA +V G+ +++ + F TL VT Sbjct: 347 TSCGLDMGPLVTGAARDKVTGYIDTGVAQGAELVVDGRGYKVAGHENGFFLGGTLFDRVT 406 Query: 430 QDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGM 489 +M EE FGP+ +++ ++ EEA+ + N + G +++D +++EVGM Sbjct: 407 PEMTIYKEEIFGPVLCIVRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGM 466 Query: 490 VGVNEGL-ISSVECPFGGVKQSGLGREGSKYGID 522 VGVN L + FGG K+S G + YG D Sbjct: 467 VGVNVPLPVPVAYHSFGGWKRSLFG-DLHAYGPD 499 >3RJL-A nrPDB Length = 538 Score = 182 bits (462), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 128/450 (28%), Positives = 215/450 (47%), Gaps = 18/450 (4%) Query: 87 LGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAES 146 +G V+ A A++AA +AF WR +ER+++L + + + K + + ++ E+ Sbjct: 65 VGTVSKATQDHAEKAIQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEA 124 Query: 147 GKPLKEAHGEILYSAFFLEWFSEEARRV-YGDIIHTPAKDRRALVLKQPIGVAAVITPWN 205 GKP EA + + F+E+++ + + G +++ +R V P GV VI PWN Sbjct: 125 GKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSREGERNQYVY-TPTGVTVVIPPWN 183 Query: 206 FPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAK 265 F A++ A + G TVV+KPA P A E+ ++G+P GV N +P S Sbjct: 184 FLFAIMAGTTVAPIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGS---GA 240 Query: 266 EVGEAICTDPLVSKISFTGSTTTGKILLHHAA------NSVKRVSMELGGLAPFIVFDSA 319 EVG+ + P S I+FTGS G + AA +K+V E+GG +V + Sbjct: 241 EVGDYLVDHPKTSIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDC 300 Query: 320 NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTT 379 +++ A S F GQ C ++ +V ++D +K E + ++ +VG Sbjct: 301 DIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYDEVLKRVIE-ITESKKVGEPDSADVY 359 Query: 380 QGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEET 439 GP+I++ + K+ + +G +V+GGK F EPT+ ++ EE Sbjct: 360 MGPVIDQASFNKIMDYIEIGKEEG-RLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEI 418 Query: 440 FGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISS 499 FGP+ K + +EA+ +AN + GL G +++ I R ++ VG + N + Sbjct: 419 FGPVVAFSKVSSFDEALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGA 478 Query: 500 V--ECPFGGVKQSGLGREGSKYGIDEYLEL 527 + PFGG K SG SK G +YL L Sbjct: 479 IVGYHPFGGFKMSGT---DSKAGGPDYLAL 505 >4ZZ7-A nrPDB Length = 501 Score = 182 bits (462), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 135/451 (29%), Positives = 221/451 (49%), Gaps = 12/451 (2%) Query: 78 VQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDD 137 V +PA+G + + A+ AA AF WR +R+ ++ ++ L+ Q+ D+ Sbjct: 25 VFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADE 84 Query: 138 LARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGV 197 + R+I E GK +A GE+ +E+ + G+ + QP+GV Sbjct: 85 ICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQPMGV 144 Query: 198 AAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVI 257 A ITP+NFP + A+ G V+KP+E P S L +A+L +AG+P GV NV+ Sbjct: 145 VAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVV 204 Query: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 317 KE +A+ D V +SF GST + + A+ + KR G IV Sbjct: 205 ----NGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMP 260 Query: 318 SANVDQAVAGAMASKFRNTGQTCVC-SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 376 A++D AV + + F ++G+ C+ S V DA V +AM+K L+VG + Sbjct: 261 DADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQK-LKVGPSTDS 319 Query: 377 GTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN----FFEPTLLCNVTQDM 432 G GP+I + EKV +N A +GAT+V G++ ++ + F TL+ +VT +M Sbjct: 320 GNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEM 379 Query: 433 LCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGV 492 EE FGP+ V++ T ++A+ + +A + G +++D ++ ++VGMVG+ Sbjct: 380 TSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGI 439 Query: 493 NEGL-ISSVECPFGGVKQSGLGREGSKYGID 522 N L + FGG K+S G + YG D Sbjct: 440 NIPLPVPVAYHSFGGWKRSLFG-DLHAYGPD 469 >6DBB-A nrPDB Length = 511 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 135/466 (28%), Positives = 224/466 (48%), Gaps = 29/466 (6%) Query: 79 QDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDL 138 + P GA L +A +A + AA++AF +WR V A R L+R + N++ ++K +L Sbjct: 33 RSPLDGATLATLAVDTPADAERKIDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAEL 92 Query: 139 ARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVA 198 R++T E+GK E GE+ ++ +R++YG I + R + PIGV Sbjct: 93 GRLVTLEAGKITSEGLGEVQEMIDICDFAVGLSRQLYGLTIASERPGHRMMETWHPIGVC 152 Query: 199 AVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA---------GI 249 VI+ +NFP A+ A G +VV KP+E TP +A+A L +A G+ Sbjct: 153 GVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHPGV 212 Query: 250 -PSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG 308 P+ + ++ R +VGE + V +S TGS G+ + + + R +ELG Sbjct: 213 APAELGQLVLGMR----DVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELG 268 Query: 309 GLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL 368 G IV SA++D V + GQ C + +V R + + + +A ++ Sbjct: 269 GNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAY-ASV 327 Query: 369 RVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK--NFFEPTLLC 426 +VGN EEGT GPL++ + + ++K + DA +G V GG+R +G ++ + Sbjct: 328 KVGNPLEEGTLVGPLVDRASFDAMQKALADAREQGGE-VKGGERVDVGHADAYYVRPAIV 386 Query: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL- 485 + + ETF P+ V+ +D ++AI + NA GL+ ++ D R AEQ Sbjct: 387 RMPKQSAVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTND----MREAEQFM 442 Query: 486 -----EVGMVGVNEGLI-SSVECPFGGVKQSGLGREGSKYGIDEYL 525 + G+V VN G + + FGG K++G GRE Y+ Sbjct: 443 SAAGSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYM 488 >2J5N-A nrPDB Length = 516 Score = 174 bits (441), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 143/478 (29%), Positives = 230/478 (48%), Gaps = 27/478 (5%) Query: 64 FVGGRWLPAAATFPVQDP-ASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSS 122 ++GG W+ +P A +G A G EA AA+ AA++AF W++ ++RS Sbjct: 41 YIGGEWVDTKERMVSLNPSAPSEVVGTTAKAGKAEAEAALEAAWKAFKTWKDWPQEDRSR 100 Query: 123 LLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG---DII 179 LL K LM + K +L + E GK EA ++ + F+E+++ A R +++ Sbjct: 101 LLLKAAALMRRRKRELEATLVYEVGKNWVEASADVAEAIDFIEYYARAALRYRYPAVEVV 160 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 P +D + + P+G VI PWNFP A+ T + +A G TV+ KPAED Sbjct: 161 PYPGEDNESFYV--PLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVIAKPAEDAVVVGAK 218 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 + E+ +AG P GV N +P +EVG + P + I+FTGS G + ++ AA Sbjct: 219 VFEIFHEAGFPPGVVNFLPGV---GEEVGAYLVEHPRIRFINFTGSLEVG-LKIYEAAGR 274 Query: 300 V-------KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + KR +E GG IV ++A+ D A G + S + GQ C +++ ++ +G Sbjct: 275 LAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAASRLILTQGA 334 Query: 353 HDAFVKAFAEAMKKNLRVGNG-FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 ++ ++ +K+ R+ G EE GP+++ + KV + ++G +V GGK Sbjct: 335 YEPVLE---RVLKRAERLSVGPAEENPDLGPVVSAEQERKVLSYIEIGKNEG-QLVLGGK 390 Query: 412 RHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 R + F PT+ V EE FGP+ VI+ EA+ +AN GL G Y Sbjct: 391 RLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPYGLTGGVY 450 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEYLEL 527 S+ + + VG + N + ++ PFGG K SG +K G +YL L Sbjct: 451 SRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGT---NAKTGALDYLRL 505 >4KNA-A nrPDB Length = 495 Score = 174 bits (441), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 136/459 (29%), Positives = 218/459 (47%), Gaps = 12/459 (2%) Query: 61 TDSFVGGRWLPAAA-TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKE 119 T+ F+ G W+ A F ++P + + A + AV +A AF W + Sbjct: 10 TELFIDGAWVDGAGPVFASRNPGTNERVWEGASASADDVERAVASARRAFAAWSALDLDA 69 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII 179 R ++++++ L+++ K+ LA +I E+GKPL EA E+ A ++ G+ Sbjct: 70 RCTIVKRFAALLVERKEALATMIGRETGKPLWEARTEVASMAAKVDISITAYHERTGEK- 128 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 P D A++ +P GV AV P+NFP + + AL AG TVV KP+E P A A Sbjct: 129 RAPMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARA 188 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 E+ AG+P+GV N++ + K+ G A+ + + FTGS+ TG +L Sbjct: 189 TVEIWRDAGLPAGVLNLV----QGEKDTGVALANHRQIDGLFFTGSSDTGTLLHKQFGGR 244 Query: 300 VKRV-SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG-IHDAFV 357 + V ++E+GG P +V + ++D AV A+ S F + GQ C C+ + LV RG D FV Sbjct: 245 PEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDRFV 304 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 A+ K + G +I+ +A ++ V GA+ + K+ Sbjct: 305 ARLADVASKITASVFDADPQPFMGAVISARAASRLVAAQARLVGLGASPIIEMKQRDPAL 364 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F +L +VT EE FGPLA ++++ ++AIA AN GL+ + D Q Sbjct: 365 GFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLLADD-EQ 422 Query: 478 IWRVAEQ-LEVGMVGVNEGLI-SSVECPFGGVKQSGLGR 514 W + + G+V N +S PFGG +SG R Sbjct: 423 AWHTFRRAIRAGIVNWNRPTNGASSAAPFGGAGRSGNHR 461 >4X0T-A nrPDB Length = 513 Score = 172 bits (437), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 124/462 (26%), Positives = 207/462 (44%), Gaps = 4/462 (0%) Query: 67 GRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRK 126 G W PA+ + V V + V+ A EA+ W ++ A +R ++R+ Sbjct: 31 GSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQ 90 Query: 127 WYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDR 186 + + + L +++ E GK L E GE+ ++ +R + G I+ + Sbjct: 91 IGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGH 150 Query: 187 RALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQ 246 + P+G+ +IT +NFP A+ A+ G + K A T ++A+ ++ ++ Sbjct: 151 ALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAK 210 Query: 247 AGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSME 306 + + I ++G A+ D V+ +SFTGST GK + R +E Sbjct: 211 VLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLE 270 Query: 307 LGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366 LGG I F+ A++ V A+ + GQ C + + + IHD V +A + Sbjct: 271 LGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQ 330 Query: 367 NLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLC 426 +RVGN ++ GPL ++AV V +A +G TVV GGK N+ EPT++ Sbjct: 331 -IRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVT 389 Query: 427 NVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI--WRVAEQ 484 + D H ETF P+ V KF EEE A N GL+ +++D +I W + Sbjct: 390 GLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKG 449 Query: 485 LEVGMVGVNEGLI-SSVECPFGGVKQSGLGREGSKYGIDEYL 525 + G+V VN + + FGG K +G GRE +Y+ Sbjct: 450 SDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYM 491 >3JU8-A nrPDB Length = 490 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 144/469 (30%), Positives = 219/469 (46%), Gaps = 21/469 (4%) Query: 55 SAALLRTDSFVGGRWLPAAA-TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 S A++ T ++ G+WL T DP + + AAV AA EAF W Sbjct: 1 SNAMMSTH-YIAGQWLAGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWA 59 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS----AFFLEWFSE 169 ++R LL ++ + D+LAR+I E+GKPL E+ E+ A ++ F E Sbjct: 60 RRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRE 119 Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 G P D A++ +P GV AV P+NFP + + AL AG VV KP Sbjct: 120 RTGEKSG-----PLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKP 174 Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289 +E TP A + QAG+P+GV N++ + +E G A+ + + FTGS+ TG Sbjct: 175 SELTPKVAELTLKAWIQAGLPAGVLNLV----QGGRETGVALAAHRGLDGLFFTGSSRTG 230 Query: 290 KILLHHAANSVKRV-SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348 +L +++ ++E+GG P +V + A++D AV + S F + GQ C C+ + LV Sbjct: 231 NLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLV 290 Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTT--QGPLINEKAVEKVEKQVNDAVSKGATV 406 +G + A A+ LRVG F+E G +I+ A E + K + KGA Sbjct: 291 PQGAWGDALLARLVAVSATLRVGR-FDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQP 349 Query: 407 VTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGL 466 + + G P +L +V+ EE FGPL VI++ AI ANA GL Sbjct: 350 LLAMTQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGL 408 Query: 467 AGYFYSQDPAQIWRVAEQLEVGMVGVNEGLI-SSVECPFGGVKQSGLGR 514 A S + + + G+V N+ L ++ PFGG+ SG R Sbjct: 409 AAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHR 457 >4I3V-A nrPDB Length = 488 Score = 165 bits (417), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 126/426 (29%), Positives = 212/426 (49%), Gaps = 21/426 (4%) Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 +++ ER +L + K++++ +IT E G ++ E+ + + R Sbjct: 66 KLTRYERQKILLATAEALAARKEEISDVITLELGISKADSLYEVGRAFDVFTLAGQMCIR 125 Query: 174 VYGDIIH---TP-AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 G+I TP K R+ +++P+ + ITP+N P M+ KV A+A VVVKP Sbjct: 126 DDGEIFSCDLTPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKP 185 Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289 E TP +AL LA++ +AG+P + +V+ ++G + T+P V ++FTGS G Sbjct: 186 TELTPMTALLLADILYEAGLPPEMLSVVTGW---PADIGMEMITNPHVDLVTFTGSVPVG 242 Query: 290 KILLHHAANS-VKRVSMELGGLAPFIVFDSANVD---QAVAGAMASKFRNTGQTCVCSNQ 345 K++ AAN+ KR +ELGG P I+ + + D +A A+A +N+GQ C + Sbjct: 243 KLI---AANAHYKRQVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKR 299 Query: 346 FLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGAT 405 L Q + D FV E K+ LR G+ + T G +I+EKA E++V A +GA Sbjct: 300 ILCQESVADRFVPLVLERAKR-LRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGAD 358 Query: 406 VVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAIAIANAADV 464 ++ R P ++ V EETFGP+ P+++ D ++ I ++N+ Sbjct: 359 ILYHPGR---SGALLPPIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAF 415 Query: 465 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLG-REGSKYGID 522 GL+ + D ++ + L+VG V + E +E PFGG+K SG G +EG + Sbjct: 416 GLSSGVCTNDYRRMQKYIAGLKVGTVNIWEVPGYRIEMSPFGGIKDSGNGYKEGVIEAMK 475 Query: 523 EYLELK 528 + +K Sbjct: 476 SFTNVK 481 >4H7N-A nrPDB Length = 474 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 133/464 (28%), Positives = 210/464 (45%), Gaps = 42/464 (9%) Query: 75 TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQN 134 T V++P +G ++ R A A RW+E+ + R + L++W ++ Sbjct: 7 TIEVRNPRTGKFDYVIIPPPPRLLAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSR 66 Query: 135 KDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG---DIIHTPAKDRRA--L 189 ++ L + ++G+ + + ++ F R G +++ T AK+ + Sbjct: 67 REQLTEALVNDTGR--------LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFI 118 Query: 190 VLKQ---PIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP-FSALALAELAS 245 L+Q P + VI+PWNFP + AL AGC VVVKP+E P F A L L Sbjct: 119 ALQQSLVPYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMAL-- 176 Query: 246 QAGIPSGVYNVIPCSR------KNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 N +P R + E G + V + FTGS TG+ + AA Sbjct: 177 ---------NTVPELRDVLIFVEGGGETGANLIN--YVDFVCFTGSVATGREVAETAARR 225 Query: 300 VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKA 359 +ELGG P IV +SAN++ A + + NTGQ+C+ + V + F Sbjct: 226 FIPAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQ 285 Query: 360 FAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNF 419 A L++ E GP+I EK + + DAV KGA + GGK +LG + Sbjct: 286 LI-AKAHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKVEELGGGW 344 Query: 420 F-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI 478 + PT++ NV M EETFGP+ PV+ F EEA+ +AN GL+ ++ + Sbjct: 345 WCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEA 404 Query: 479 WRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYG 520 +VA QL G + +N+ ++++ E SGLG GS+ G Sbjct: 405 LKVARQLNAGAISINDAALTAMMHEGEKNAFNFSGLG--GSRVG 446 >4E4G-A nrPDB Length = 521 Score = 160 bits (405), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 121/449 (26%), Positives = 215/449 (47%), Gaps = 12/449 (2%) Query: 80 DPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLA 139 +PA+G G VA + AAV +A A +W + + R+ + K+ L+ N ++LA Sbjct: 48 NPATGEVQGTVALASDADLAAAVESAKAAQPKWAATNPQRRARVFMKFVQLLNDNMNELA 107 Query: 140 RIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199 +++ E GK + +A G+I+ E+ + ++QP+G+ A Sbjct: 108 EMLSREHGKTIDDAKGDIVRGLEVCEFVIGIPHLQKSEFTEGAGPGIDMYSIRQPVGIGA 167 Query: 200 VITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPC 259 ITP+NFP + A+A G ++KP+E P + LAEL +AG+P+G+ NV+ Sbjct: 168 GITPFNFPGMIPMWMFAPAIACGNAFILKPSERDPSVPIRLAELMIEAGLPAGILNVV-- 225 Query: 260 SRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSA 319 K +AI T P ++ +SF GST + + AA + KR G I+ A Sbjct: 226 --NGDKGAVDAILTHPDIAAVSFVGSTPIARYVYGTAAMNGKRAQCFGGAKNHMIIMPDA 283 Query: 320 NVDQAVAGAMASKFRNTGQTCVC-SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGT 378 ++DQA + + + + G+ C+ S V + + M ++LR+G +E Sbjct: 284 DLDQAANALIGAGYGSAGERCMAISVAVPVGEETANRLIDKLV-PMVESLRIGPYTDEKA 342 Query: 379 TQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL----GKNFFEPTLLCNVTQDMLC 434 GP++ ++A +++ ++ + +GA +V G+ +L +F L +VT DM Sbjct: 343 DMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKLQGYENGHFIGGCLFDDVTPDMDI 402 Query: 435 THEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNE 494 E FGP+ V++ EEA+++ + G Y++D A ++ +GMVGVN Sbjct: 403 YKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAIYTRDGDAARDFASRINIGMVGVNV 462 Query: 495 GL-ISSVECPFGGVKQSGLGREGSKYGID 522 + + FGG K S G + +++G D Sbjct: 463 PIPVPLAYHSFGGWKSSSFG-DLNQHGTD 490 >5UCD-A nrPDB Length = 457 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 112/412 (27%), Positives = 189/412 (45%), Gaps = 43/412 (10%) Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKP-----LKEAHGEILYS-----AFFLEWFSE 169 R L + +I NK+ L + + GKP L E G +L+ A EW + Sbjct: 52 RKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEI-GAVLHEIDFALAHLDEWVAP 110 Query: 170 EARRVYGDIIHTPAKDRRA----LVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTV 225 + P+ D A V+++P GV +I P+N+P + + A+ G T Sbjct: 111 ---------VSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTPLIGAIIGGNTC 161 Query: 226 VVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGS 285 ++KP+E TP ++ + ++ ++A P V + + ++ + + P I FTGS Sbjct: 162 IIKPSETTPETSAVIEKIIAEAFAPEYVAVI-----QGGRDENSHLLSLPF-DFIFFTGS 215 Query: 286 TTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQ 345 GK+++ AA + V +ELGG P IV A++DQ V M KF N+GQT + + Sbjct: 216 PNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQTXIAPDY 275 Query: 346 FLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGAT 405 V + DA ++ E +K L E + G L+ E+ V+++ + ++G Sbjct: 276 LYVHYSVKDALLERLVERVKTEL------PEINSTGKLVTERQVQRLVSLLE--ATQGQV 327 Query: 406 VVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVG 465 +V G + + K T++ V + EE FGP+ PV++FD+ AI N Sbjct: 328 LV--GSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPK 385 Query: 466 -LAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLIS--SVECPFGGVKQSGLGR 514 LA Y + +D + Q++ G VN ++ S PFGG+ SG+G Sbjct: 386 PLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGE 437 >1AD3-A nrPDB Length = 452 Score = 134 bits (337), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 127/436 (29%), Positives = 196/436 (44%), Gaps = 54/436 (12%) Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160 V+ A EAF S K RS R IQ + L R+I LK G + Sbjct: 6 TVKRAREAFN-----SGKTRSLQFR------IQQLEALQRMINEN----LKSISGALASD 50 Query: 161 AFFLEW--FSEEARRVYGDIIHT------------PAKDRRA-----LVLKQPIGVAAVI 201 EW + EE V ++ T AK R+ + +P+GV VI Sbjct: 51 LGKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVI 110 Query: 202 TPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSR 261 WN+P + + + A+AAG V++KP+E + A LA L Q + +Y V+ + Sbjct: 111 GAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVV---K 166 Query: 262 KNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANV 321 E E + I +TGST GKI++ AA + V++ELGG +P V ++ Sbjct: 167 GGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDL 224 Query: 322 DQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTT 379 D A KF N+GQTCV + L I + V E +KK+L+ G ++ Sbjct: 225 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKDFYGEDAKQSRD 280 Query: 380 QGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEET 439 G +IN++ ++V+ +++ V GG Q + + PT+L +V EE Sbjct: 281 YGRIINDRHFQRVKGLIDN-----QKVAHGGTWDQSSR-YIAPTILVDVDPQSPVMQEEI 334 Query: 440 FGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--I 497 FGP+ P++ + EEAI N + LA Y +S + I ++ + G V N+ + I Sbjct: 335 FGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHI 394 Query: 498 SSVECPFGGVKQSGLG 513 + PFGGV SG+G Sbjct: 395 TVPTLPFGGVGNSGMG 410 >3SZA-A nrPDB Length = 469 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 122/436 (27%), Positives = 200/436 (45%), Gaps = 32/436 (7%) Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159 AV+ A AF R + R L L+ + + +L + A+ K A+ E++Y Sbjct: 23 AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 82 Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVG 216 +E+ ++ D + TP + L + +P+GV VI WN+P + + + Sbjct: 83 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 142 Query: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVI----PCSRKNAKEVGEAIC 272 A+AAG VV+KP+E + A LA + Q + +Y VI P + + KE + I Sbjct: 143 GAIAAGNAVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFDHIL 201 Query: 273 TDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASK 332 +TGST GKI++ AA + V++ELGG +P V + ++D A K Sbjct: 202 ---------YTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 252 Query: 333 FRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVE 390 F N+GQTCV + L I + V E +KK+L+ G ++ G +I+ + + Sbjct: 253 FMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQ 308 Query: 391 KVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFD 450 +V + +G V GG + PT+L +V EE FGP+ P++ Sbjct: 309 RVM-----GLIEGQKVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 362 Query: 451 TEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVK 508 + EEAI N + LA Y +S + I ++ + G V N+ + I+ PFGGV Sbjct: 363 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 422 Query: 509 QSGLGREGSKYGIDEY 524 SG+G K + + Sbjct: 423 NSGMGSYHGKKSFETF 438 >4QGK-A nrPDB Length = 461 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 92/339 (27%), Positives = 161/339 (47%), Gaps = 16/339 (4%) Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247 A + QP+GV +I WN+P + + + A+AAG V++KP+E + +A LA+L Q Sbjct: 96 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 155 Query: 248 GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMEL 307 + +Y VI + E+ + I +TG+T GKI++ AA + V++EL Sbjct: 156 -LDQDLYIVINGGVEETTELLKQ-----RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 209 Query: 308 GGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKN 367 GG +P + ++D K+ N GQTC+ + L + + + V E +K+ Sbjct: 210 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE- 268 Query: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 427 G +E +IN + +++ ++ +G + GG+ + + PT+L + Sbjct: 269 -FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE-ATRYIAPTVLTD 321 Query: 428 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 487 V EE FGP+ P++ +EAI N + LA Y +S + I R+ ++ Sbjct: 322 VDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 381 Query: 488 GMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 524 G V N+ ++ PFGGV SG+G K+ D + Sbjct: 382 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 420 >5NNO-A nrPDB Length = 546 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 126/479 (26%), Positives = 208/479 (43%), Gaps = 42/479 (8%) Query: 83 SGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARII 142 S A G+ + + V EAF K+R +LR NL+ +N D+ + I Sbjct: 2 SMAPAGVPENTSLENIPVIVSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAI 61 Query: 143 TAESGKPLKEA--------HGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194 + + E E+ + +E E + V + A D L +P Sbjct: 62 HRDRRRHRDETVVMEILPLRNEVWH---LIEHMDEYVKPVKPTMEGAAALDDCELQY-EP 117 Query: 195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVY 254 +GV VI WN+P +I + + ALAAG T V+KP+E P +A L +L + + S V Sbjct: 118 LGVVLVIGTWNYPLLLILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKY-VSSDVV 176 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFI 314 ++ N I +TGS +I++ AA + V++ELGG +P + Sbjct: 177 GIV-----NGGVSETTAVLKERFDHILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVV 231 Query: 315 VFDSA--NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMK-----KN 367 V D+ N+ M K N GQT + + +V++ + V A AEA K K Sbjct: 232 VDDTCADNMKVVAERIMWGKIINAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKF 291 Query: 368 LRVGNG---------FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN 418 L+V G F E + ++N +++ + + KG V GG+ + Sbjct: 292 LKVLKGELLVKQKQQFLEESDYPRIVNASHFQRLMEFM-----KGGKVAVGGEADEATLT 346 Query: 419 FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI 478 PT+L N+ EE FGP+ PV+ ++ E++ + I N+ + LA Y +S + I Sbjct: 347 -IAPTILTNIDPTHPVMQEEIFGPILPVLTYENEKDILKIINSREKPLALYVFSNNKRFI 405 Query: 479 WRVAEQLEVGMVGVNEGLISSVE--CPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL 535 V + G V VN+ ++ + PFGGV +SG+G +Y + + + V G Sbjct: 406 RGVESRTSSGAVVVNDVVVHAGADGLPFGGVGRSGMGAYHGRYSFETFSHRRPVMRRGF 464 >4LGZ-A nrPDB Length = 563 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 86/331 (25%), Positives = 153/331 (46%), Gaps = 20/331 (6%) Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 G A I+P+NF +A+ GA G V+ KP++ ++ A+ + +AG+P + Sbjct: 202 GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ 260 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGG 309 +P + G+ + + + I+FTGS T K L A ++ R ++ E GG Sbjct: 261 FVPA---DGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGG 317 Query: 310 LAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR 369 V SA+VD V+G + S F GQ C ++ V + + E + ++ Sbjct: 318 KNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSR-IK 376 Query: 370 VGNGFEE-GTTQGPLINEKAVEKVEKQVNDAVSKGA-TVVTGGKRHQLGKNFFEPTLLCN 427 VG+ E+ GT +I+ KA +++K + A S + +++ GG+ ++ + EP ++ + Sbjct: 377 VGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIES 436 Query: 428 VTQDMLCTHEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQ 484 EE FGP+ V + D E + + ++ GL G ++QD A + Sbjct: 437 KDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRM 496 Query: 485 LE--VGMVGVNEGLISSV--ECPFGGVKQSG 511 L G +N+ SV + PFGG + SG Sbjct: 497 LRNAAGNFYINDKSTGSVVGQQPFGGARASG 527 >4OE4-A nrPDB Length = 580 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 117/466 (25%), Positives = 199/466 (42%), Gaps = 32/466 (6%) Query: 74 ATFPVQDPASGA-ALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM- 131 A FP +PA+ L V ++ AV+AA +A W + +RS++ K +L+ Sbjct: 76 ALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAADLIS 135 Query: 132 IQNKDDLARIITAESGKPLKEAHGE-ILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALV 190 + + D+ GK + +A + I + F ++ + A +Y A Sbjct: 136 TKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKA 195 Query: 191 LKQPI-GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGI 249 +P+ G ++P+NF +A+ +GA G TVV KP++ S L + +AG+ Sbjct: 196 EYRPLEGFVYAVSPFNF-TAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGL 254 Query: 250 PSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV--------K 301 P GV N IP + +V + + D + FTGST K L + V Sbjct: 255 PKGVINFIPG---DPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYP 311 Query: 302 RVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV-KAF 360 R+ E GG +V SAN+ AV + F GQ C +++ + + F+ F Sbjct: 312 RIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMF 371 Query: 361 AEAMKKNLRVGNGFEEGTT-------QGPLINEKAVEKVEKQVNDAVSKGA-TVVTGGKR 412 +N+ N + GP+I+E++ +K+ K + DA ++ GG+ Sbjct: 372 GILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQY 431 Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAI--AIANAADVGLAGY 469 + F PT++ D E FGP+ V ++ DTE I I N + L G Sbjct: 432 DKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGA 491 Query: 470 FYSQDPAQIWRVAEQLEV--GMVGVNEGLISSV--ECPFGGVKQSG 511 +++D I E+L+ G +N+ +V + FGG + SG Sbjct: 492 IFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSG 537 >3V9H-A nrPDB Length = 566 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 86/331 (25%), Positives = 148/331 (44%), Gaps = 20/331 (6%) Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 G A I+P+NF +A+ GA G V+ KP++ ++ A+ + +AG+P + Sbjct: 205 GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ 263 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSM------ELGG 309 +P + G+ + + + I+FTGS T K L A ++ R E GG Sbjct: 264 FVPA---DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGG 320 Query: 310 LAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR 369 V SA+V+ V+G + S F GQ C + V + E + ++ Sbjct: 321 KNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSR-IK 379 Query: 370 VGNGFEE-GTTQGPLINEKAVEKVEKQVNDAVSKGA-TVVTGGKRHQLGKNFFEPTLLCN 427 VG+ E+ GT +I+ K+ +++K + A S + T++ GGK F EP ++ + Sbjct: 380 VGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVES 439 Query: 428 VTQDMLCTHEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQ 484 EE FGP+ V + D +E + + ++ GL G +SQD + + Sbjct: 440 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 499 Query: 485 LE--VGMVGVNEGLISSV--ECPFGGVKQSG 511 L G +N+ S+ + PFGG + SG Sbjct: 500 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 530 >3V4C-A nrPDB Length = 528 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 114/425 (26%), Positives = 169/425 (39%), Gaps = 63/425 (14%) Query: 64 FVGGRWLPAAATF---PVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120 V G WL A TF P PA A+G V A AA EAF + S KER Sbjct: 33 LVAGEWLDGAGTFASAPAHGPAHDFAVGTV-----ELVNRACEAAEEAFWTYGYSSRKER 87 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII- 179 ++ LR + + + + I + E+G P +GE + L F++ + GD + Sbjct: 88 AAFLRAIADEIEARAEAITEIGSQETGLPEARLNGERGRTTGQLRLFADHIEK--GDYLD 145 Query: 180 ---------HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITR--KVGAALAAGCTVVVK 228 PA + ++++P+G AV NFP A T AALAAGC VVVK Sbjct: 146 RRVDAAMPERQPAPRQEIRLVQRPVGPVAVFGASNFPLAFSTAGGDTAAALAAGCPVVVK 205 Query: 229 PAEDTPFSALALAELASQA----GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 284 P + +AE A G+ GV+++I + +++VG A+ P + + FTG Sbjct: 206 GHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLI---QGGSRDVGHALVQHPHIKAVGFTG 262 Query: 285 STTTGKILLHHAANSVKRVSM--ELGGLAPFIVFDSA------NVDQAVAGAMASKFRNT 336 S G+ L A + + ELG + P + A + Q AG++ Sbjct: 263 SLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEALKARAETLGQGWAGSLT---MGA 319 Query: 337 GQTCVCSNQFLVQRGIH-DAFVKAFAEAMKK---NLRVGNGFEEGTTQGPLINEKAVEKV 392 GQ C +V G D F A EA+ K + +G + G + Sbjct: 320 GQFCTNPGIAVVIEGADADRFTTAAVEALAKVAPQTMLTDGIAKAYRDG---------QA 370 Query: 393 EKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTH---EETFGPLAPVIKF 449 +AV + G+ N FE T L H EE FGPL V++ Sbjct: 371 RFATRNAVKPLLATESSGR--DASPNLFETT-----GAQFLADHALGEEVFGPLGLVVRV 423 Query: 450 DTEEE 454 + E Sbjct: 424 GSPAE 428 >2Y53-A nrPDB Length = 534 Score = 78.2 bits (191), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 114/460 (24%), Positives = 183/460 (39%), Gaps = 48/460 (10%) Query: 63 SFVGGRWLPAA-ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERS 121 + V G+W+ A + DP +G AL V+ G+ ARA A + R ++ +R+ Sbjct: 10 NHVAGQWIAGTGAGITLTDPVTGVALVRVSSEGLDLARAFSFAREDGGAALRALTYAQRA 69 Query: 122 SLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE------EARRVY 175 + L L+ + D I TA SG ++ +I F L ++++ E + Sbjct: 70 ARLADIVKLLQAKRGDYYAIATANSGTTRNDSAVDIDGGIFTLSYYAKLGASLGEVHALR 129 Query: 176 GDIIHTPAKDRR---ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + +KDR VL GVA I +NFPS + K AL +G V+VKPA Sbjct: 130 DGSAESLSKDRSFSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALLSGVPVIVKPATA 189 Query: 233 TPFSALALAELASQAGI-PSGVYNVIPCSRKNAKEVGEAICTDPLVS--KISFTGSTTTG 289 T + + AGI P G ++I S A D + S +SFTGS T Sbjct: 190 TAWLTQRMVADVVDAGILPPGALSIICGS--------SAGLLDQIRSFDVVSFTGSADTA 241 Query: 290 KILLHHAANSVK--RVSMELGGLAPFIVF-----DSANVDQAVAGAMASKFRNTGQTCVC 342 L H A + R++++ L I+ D+ D + + +GQ C Sbjct: 242 ATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKSGQKCTA 301 Query: 343 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKV--------EK 394 + V + ++A + K + VGN + G L++ + E V E+ Sbjct: 302 IRRAFVPEAALEPVLEALKAKLAK-ITVGNPRNDAVRMGSLVSREQYENVLAGIAALREE 360 Query: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE-ETFGPLAPVIKF---- 449 V S ++ + + N + H+ E FGP+A V + Sbjct: 361 AVLAYDSSAVPLIDADA--NIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPYRVTT 418 Query: 450 DT----EEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485 DT E A+A+A L YS D A + R+A +L Sbjct: 419 DTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALEL 458 >4IDS-A nrPDB Length = 563 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 91/334 (27%), Positives = 132/334 (39%), Gaps = 29/334 (8%) Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 G ITP+NF S AL G TV+ KP+ +A +L AG+P GV N Sbjct: 201 GFVYAITPFNFTSIAGNLPTAPALM-GNTVIWKPSITQTLAAYLTMQLLEAAGLPPGVIN 259 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA------NSVKRVSMELGG 309 ++ + V + DP ++ I FTGST T L +S R+ E GG Sbjct: 260 LV---TGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGTNIGRYHSYPRLVGETGG 316 Query: 310 LAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKK--N 367 + SA D + F GQ C ++ + H + + E + K Sbjct: 317 KDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIA---HSVWQRMGDELLAKAAE 373 Query: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA---TVVTGGKRHQLGKNFFEPTL 424 LR G+ + G LI+++A K + A KGA TV GG+ F PT+ Sbjct: 374 LRYGDITDLSNYGGALIDQRAFVKNVDAIERA--KGAAAVTVAVGGEYDDSEGYFVRPTV 431 Query: 425 LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVG----LAGYFYSQDPAQIWR 480 L + E FGPL V + +E I + D G L G + D + Sbjct: 432 LLSDDPTDESFVIEYFGPLLSVHVY-PDERYEQILDVIDTGSRYALTGAVIADDRQAVLT 490 Query: 481 VAEQLEV--GMVGVNEGLISSV--ECPFGGVKQS 510 ++L G VN+ +V PFGG + S Sbjct: 491 ALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 >1EZ0-A nrPDB Length = 510 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 104/224 (46%), Gaps = 19/224 (8%) Query: 112 WREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE-- 169 +R ++ +R+SLLR + + DD+ E+ P GEI +A L F++ Sbjct: 46 FRRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVRLTGEIARTANQLRLFADVV 105 Query: 170 EARRVYGDIIHTPAKDRRAL----VLKQPI--GVAAVITPWNFPSAMITR--KVGAALAA 221 + + I+ TP R L + +Q I G AV NFP A +ALAA Sbjct: 106 NSGSYHQAILDTPNPTRAPLPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAA 165 Query: 222 GCTVVVKPAEDTPFSALALAELASQA----GIPSGVYNVIPCSRKNAKEVGEAICTDPLV 277 GC V+VK P ++ +AE QA +P ++ ++ + N + +G+A+ + P + Sbjct: 166 GCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLL---QGNQRALGQALVSHPEI 222 Query: 278 SKISFTGSTTTGKILLHHAANSVKRVSM--ELGGLAPFIVFDSA 319 + FTGS G+ L + A + + ELG + P +F SA Sbjct: 223 KAVGFTGSVGGGRALFNLAHERPEPIPFYGELGAINPTFIFPSA 266 >6D97-A nrPDB Length = 547 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 100/443 (22%), Positives = 167/443 (37%), Gaps = 48/443 (10%) Query: 63 SFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRA--------------AYEA 108 +FV G W +A + DP +G VA+ E ++ + + A E Sbjct: 47 NFVQGSWTASANWNWIVDPLNGDKFIKVAEVQGTEIKSFMESLSKCPKHGLHNPLKAPER 106 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 168 + + ++SAK L + D A++I S K ++A E+ S FLE F Sbjct: 107 YLMYGDISAKAAHMLGQP------TVLDFFAKLIQRVSPKSYQQALAEVQVSQKFLENFC 160 Query: 169 EEARRVYGDIIHTPAKD--RRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVV 226 + R P +R+ + P G A+ITP+NFP + ++ AL G V Sbjct: 161 GDQVRFLARSFAVPGNHLGQRSNGYRWPYGPVAIITPFNFPLEIPLLQLMGALYMGNKPV 220 Query: 227 VKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGST 286 +K + L G+P+ + I + V + + FTGS+ Sbjct: 221 LKVDSKVSIVMEQMIRLLHDCGLPAEDMDFI----NSDGAVMNKLLLEANPKMTLFTGSS 276 Query: 287 TTGKILLHHAANSVKRVSMELGGLAPFIV-FDSANVDQAVAGAMASKFRNTGQTCVCSNQ 345 + L AA+ RV +E G I+ D VD + +GQ C + Sbjct: 277 RVAEKL---AADLKGRVKLEDAGFDWKILGPDVQEVDYVAWVCDQDAYACSGQKCSAQSV 333 Query: 346 FLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGAT 405 + + + E MKK L E+ T GP++ +E N +G+ Sbjct: 334 LFMHKNWSSS---GLLEKMKK-LSERRKLEDLTI-GPVLTVTTEAMIEHMNNLLKIRGSK 388 Query: 406 VVTGGK---RHQLGKNF--FEPTLLCNVTQDML------CTHEETFGPLAPVIKF--DTE 452 V+ GG+ H + K + +PT + +++L +E FGP V ++ D Sbjct: 389 VLFGGEPLANHSIPKIYGAMKPTAVFVPLEEILKSGNFELVTKEIFGPFQVVTEYSEDQL 448 Query: 453 EEAIAIANAADVGLAGYFYSQDP 475 E + + L S DP Sbjct: 449 ELVLEACERMNAHLTAAIVSNDP 471 >5J7I-A nrPDB Length = 488 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 48/179 (26%), Positives = 75/179 (41%), Gaps = 13/179 (7%) Query: 184 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP----AEDTPFSALA 239 ++ R + QP+G+ A I P P++ + K A+ A +V P A+ T +A Sbjct: 120 EENRVWEIAQPVGIVAGIIPSTNPTSTVIFKALIAVKARNAIVFSPHPSAAKCTAEAARI 179 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 + E A +AG P G +I C + + L I TG L AA S Sbjct: 180 MQEAAERAGAPKG---LISCITQPTMAATNELMKHKLTDVILATGGPG-----LVKAAYS 231 Query: 300 VKRVSMELG-GLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 + + +G G P + +SAN+ +AV + SK + G C LV I + V Sbjct: 232 SGKPAYGVGPGNVPVYIHESANIAKAVQLIIQSKTFDYGTICASEQALLVDESIKEKVV 290 >5DBV-A nrPDB Length = 445 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 97/231 (41%), Gaps = 14/231 (6%) Query: 97 EARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGE 156 + A+ AA EA +++S +R ++ I++ + LAR+ E+G G Sbjct: 17 DMNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETGM------GN 70 Query: 157 ILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQ--PIGVAAVITPWNFPSAMITRK 214 + + + +E+ DI T R L L + P GV ITP PS I Sbjct: 71 VGHKILKHQLVAEKTPGTE-DITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETIICN 129 Query: 215 VGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCS-RKNAKEVGEAICT 273 LA G TVV P ++ +L ++A + +G I CS RK + + + + Sbjct: 130 TIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKIMMS 189 Query: 274 DPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQA 324 + I+ TG G ++ S KR G P +V ++A++ +A Sbjct: 190 HQDIPLIAATG----GPGVVTAVLQSGKRGIGAGAGNPPVLVDETADIRKA 236 >3K9D-A nrPDB Length = 464 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 13/181 (7%) Query: 185 DRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA----L 240 +++ + + P+GV A + P P++ + K ++ AG ++V P + + L + Sbjct: 99 EKKVMEVAVPLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPHPNALKAILETVRII 158 Query: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300 +E A +AG P G I C V TD L+ TG + AA S Sbjct: 159 SEAAEKAGCPKGA---ISCMT-----VPTIQGTDQLMKHKDTAVILATGGSAMVKAAYSS 210 Query: 301 KRVSMELG-GLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKA 359 ++ +G G P + SAN+ +AV + SK + G C +V+R +A + Sbjct: 211 GTPAIGVGPGNGPAFIERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAE 270 Query: 360 F 360 F Sbjct: 271 F 271 >5UJU-A nrPDB Length = 576 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 74/286 (25%), Positives = 115/286 (40%), Gaps = 33/286 (11%) Query: 194 PIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALA-------ELASQ 246 P G V+ FP+ + A LA G TV+VKP P + L LA ++ + Sbjct: 204 PRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKP---HPGAILPLAITVRIARDVLRE 260 Query: 247 AGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSME 306 AG V ++ + N + + + P + I FTGST G L HA + +V E Sbjct: 261 AGFDPNVVTLL-ATEPNDGALVQDLALRPEIKLIDFTGSTQNGTWLERHAHQA--QVYTE 317 Query: 307 LGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQR-GIHDAFVKAFAEAM 364 G+ IV DS + +A A +A S +GQ C V R GI A A + + Sbjct: 318 KAGVNQ-IVIDSTDDLKAAAKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDEV 376 Query: 365 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFE--- 421 + + G + T P ++VE + ND V+ R L + Sbjct: 377 AQAI---AGAVQKLTGDP---ARSVELIGAIQNDGVTARIDAARAVGRVLLDSQTLQHPA 430 Query: 422 --------PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 459 P +L D +E FGP++ VI D+ +++ +A Sbjct: 431 FPDARVRTPLVLQLDVADREKFTQEWFGPISFVIATDSTAQSLDLA 476 >3MY7-A nrPDB Length = 452 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 55/264 (20%), Positives = 109/264 (41%), Gaps = 12/264 (4%) Query: 100 AAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILY 159 A V+ A E F + S ++ + R Q + LA+ ESG + E +++ Sbjct: 14 ARVKKAQEEFATY---SQEQVDKIFRAASLAANQARIPLAQQAVEESGMGIVE--DKVIK 68 Query: 160 SAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAAL 219 + F E+ + + I + + + +P+G+ I P P++ K +L Sbjct: 69 NHFASEFIYNKYKDEQTCGILEEDDNLGTMTIAEPVGIICGIVPTTNPTSTAIFKSLISL 128 Query: 220 AAGCTVVVKPAEDTPFSALALAELASQAGIPSGV-YNVIPCSRKNAKEVGEAICTDPLVS 278 ++ P S A+L A + +G ++I + + E+ A+ ++ Sbjct: 129 KTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSVELSNALMKHDDIA 188 Query: 279 KISFTGSTTTGKILLHHAANSVKRVSMELG-GLAPFIVFDSANVDQAVAGAMASKFRNTG 337 I TG K AA S + ++ +G G P ++ ++A++ +AVA + SK + G Sbjct: 189 LILATGGPGMVK-----AAYSSGKPAIGVGAGNVPVVIDETADIKRAVASVLMSKTFDNG 243 Query: 338 QTCVCSNQFLVQRGIHDAFVKAFA 361 C +V ++D + FA Sbjct: 244 VVCASEQAVIVVDEVYDEVKERFA 267 >5JFN-A nrPDB Length = 524 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 69/311 (22%), Positives = 120/311 (38%), Gaps = 36/311 (11%) Query: 189 LVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA- 247 LV P GV ITP P+ I LAAG +VV P +L L L +Q Sbjct: 182 LVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPRARQVSLLLVRLINQKL 241 Query: 248 ---GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVS 304 G P N++ K + E A+ P V + TG K +L ++ K+ Sbjct: 242 AALGAPE---NLVVTVEKPSIENTNAMMAHPKVRMLVATGGPAIVKAVL----STGKKAI 294 Query: 305 MELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM 364 G P +V ++AN+++A + + V + + V A+ + Sbjct: 295 GAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIA--------VAQIADYL 346 Query: 365 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR-----HQLGKNF 419 NL+ +E I + AV + + + G GK Q+G + Sbjct: 347 IFNLKKNGAYE--------IKDPAVLQQLQDLVLTAKGGPQTKCVGKSAVWLLSQIGISV 398 Query: 420 FEP--TLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAI--AIANAADVGLAGYFYSQDP 475 +L V ++ EE P+ P+++ +T ++AI AI D +S D Sbjct: 399 DASIKIILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIEVEHDNRHTAIMHSTDV 458 Query: 476 AQIWRVAEQLE 486 ++ ++A+ ++ Sbjct: 459 RKLTKMAKLIQ 469 >5HCE-A nrPDB Length = 998 Score = 35.4 bits (80), Expect = 0.069, Method: Compositional matrix adjust. Identities = 33/129 (25%), Positives = 55/129 (42%), Gaps = 17/129 (13%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC 110 L + AL++ D+F+ LPA +TF + A +LG R +A++ Sbjct: 483 LVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALK------- 535 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDD------LARIITAESGKPLKEAH-GEILYSAFF 163 RE K + R W + +Q+KD AR++ + L + +I Y Sbjct: 536 --REALVKGNPPIYRFWKD-NLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPV 592 Query: 164 LEWFSEEAR 172 ++W SEE R Sbjct: 593 IKWLSEEQR 601 >1FUP-A nrPDB Length = 472 Score = 32.0 bits (71), Expect = 0.65, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 451 TEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVK 508 +EE+A AI AAD LAG + P IW+ + M +NE L + GGV+ Sbjct: 66 SEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNM-NMNEVLANRASELLGGVR 122 >5YDP-A nrPDB Length = 235 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 21/95 (22%) Query: 135 KDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194 K DL R+IT E+G PL E E+L A W EA ++ R A + Sbjct: 150 KPDLLRLITTEAG-PLIERATEVLMPALSESWMRIEA-----------SQARLAASIIAR 197 Query: 195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 IG++ + P P LA+G T V+ P Sbjct: 198 IGISFISLPPEDPD---------QLASGLTEVIAP 223 >3SLK-A nrPDB Length = 795 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 62/149 (41%), Gaps = 10/149 (6%) Query: 280 ISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 339 + G +L+H AA V +++L V+ +A+ D+ A ++ + + +T Sbjct: 338 VDLAGLRPGESLLVHSAAGGVGMAAIQLARHLGAEVYATASEDKWQAVELSREHLASSRT 397 Query: 340 CVCSNQFLVQRG------IHDAFVKAFAEAMKKNL-RVGNGFEEGTT--QGPLINEKAVE 390 C QFL G + ++ FA+A + L R G E G T + P+ A Sbjct: 398 CDFEQQFLGATGGRGVDVVLNSLAGEFADASLRMLPRGGRFLELGKTDVRDPVEVADAHP 457 Query: 391 KVEKQVNDAVSKGATVVTGGKRHQLGKNF 419 V Q D V G + G H+L + F Sbjct: 458 GVSYQAFDTVEAGPQRI-GEMLHELVELF 485 >2PZM-A nrPDB Length = 330 Score = 29.3 bits (64), Expect = 5.0, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 22/34 (64%) Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAI 271 LA+A+L+ Q G P+GV+NV + KEV + + Sbjct: 225 LAIADLSLQEGRPTGVFNVSTGEGHSIKEVFDVV 258 >4APM-A nrPDB Length = 437 Score = 28.5 bits (62), Expect = 8.2, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 36/85 (42%), Gaps = 12/85 (14%) Query: 40 GPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREAR 99 G + L C +G+ A L S V +W +PV+D G G + Sbjct: 184 GTSSLLCMEPMKSGIDAHLYYGSSRVDKKWEENCPMYPVKDAIFGR--------GANGSC 235 Query: 100 AAVRAAYEAFCRWREVSAKERSSLL 124 A+ +A+E F R A+E S+L+ Sbjct: 236 VAIESAFEEFTR----DAEECSALM 256 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2W8P-A nrPDB 647 0.0 5AC2-A nrPDB 637 0.0 5AC0-A nrPDB 634 0.0 4X2Q-A nrPDB 623 e-179 5FHZ-A nrPDB 615 e-176 5L13-A nrPDB 614 e-176 1O9J-A nrPDB 613 e-176 1AG8-A nrPDB 609 e-174 3JZ4-A nrPDB 604 e-173 5GT6-A nrPDB 603 e-173 4V3F-A nrPDB 601 e-172 4MPY-A nrPDB 591 e-169 4O6R-A nrPDB 580 e-166 4PXL-B nrPDB 579 e-165 4CAZ-A nrPDB 575 e-164 4PZ2-A nrPDB 574 e-164 3IWK-A nrPDB 572 e-163 1BPW-A nrPDB 570 e-163 4V6H-A nrPDB 569 e-162 6QAO-A nrPDB 568 e-162 3IWJ-A nrPDB 565 e-161 3EK1-A nrPDB 564 e-161 3RHO-A nrPDB 562 e-160 2D4E-A nrPDB 555 e-158 4GO4-A nrPDB 554 e-158 4I8Q-A nrPDB 552 e-157 4I8P-A nrPDB 547 e-156 3R31-A nrPDB 546 e-156 4QYJ-A nrPDB 544 e-155 5J77-A nrPDB 541 e-154 6B4R-B nrPDB 540 e-154 5KLK-A nrPDB 537 e-153 2HG2-A nrPDB 536 e-152 5IUV-A nrPDB 533 e-152 1WNB-A nrPDB 530 e-151 3TY7-A nrPDB 528 e-150 4O5H-A nrPDB 528 e-150 4U3W-A nrPDB 523 e-148 6C43-A nrPDB 522 e-148 3K2W-A nrPDB 521 e-148 5EUY-A nrPDB 521 e-148 4F3X-A nrPDB 515 e-146 1T90-A nrPDB 510 e-145 4JZ6-A nrPDB 509 e-144 5X5U-A nrPDB 506 e-143 3I44-A nrPDB 506 e-143 3RHD-A nrPDB 505 e-143 2JG7-A nrPDB 505 e-143 3QAN-A nrPDB 500 e-142 3U4J-A nrPDB 500 e-142 5VBF-A nrPDB 498 e-141 4X0T-A nrPDB 496 e-141 3RJL-A nrPDB 495 e-140 3RH9-A nrPDB 494 e-140 4PXN-A nrPDB 490 e-139 2QE0-A nrPDB 487 e-138 4LIH-A nrPDB 484 e-137 4DNG-A nrPDB 483 e-136 6FK3-A nrPDB 477 e-135 4ZZ7-A nrPDB 474 e-134 3B4W-A nrPDB 473 e-134 3R64-A nrPDB 471 e-133 5TJR-A nrPDB 471 e-133 3VZ0-A nrPDB 466 e-131 4YWE-A nrPDB 465 e-131 3EFV-A nrPDB 465 e-131 5KF0-A nrPDB 465 e-131 3PRL-A nrPDB 463 e-131 5UR2-A nrPDB 463 e-131 3ROS-A nrPDB 462 e-130 5N5S-A nrPDB 458 e-129 3VZ3-A nrPDB 458 e-129 5JRY-A nrPDB 458 e-129 4OGD-A nrPDB 453 e-128 6MVR-A nrPDB 453 e-127 2J5N-A nrPDB 448 e-126 5J6B-A nrPDB 446 e-126 5U0M-A nrPDB 441 e-124 4E4G-A nrPDB 433 e-122 1UXV-A nrPDB 432 e-121 6DBB-A nrPDB 426 e-119 4KNA-A nrPDB 419 e-117 4I3V-A nrPDB 413 e-116 3JU8-A nrPDB 411 e-115 3SZA-A nrPDB 405 e-113 1AD3-A nrPDB 385 e-107 4H7N-A nrPDB 372 e-103 4QGK-A nrPDB 368 e-102 3V9H-A nrPDB 365 e-101 4LGZ-A nrPDB 363 e-100 5UCD-A nrPDB 360 e-100 4OE4-A nrPDB 349 2e-96 5NNO-A nrPDB 323 1e-88 4IDS-A nrPDB 307 8e-84 6D97-A nrPDB 257 8e-69 2Y53-A nrPDB 255 3e-68 3V4C-A nrPDB 244 8e-65 5DBV-A nrPDB 209 3e-54 1EZ0-A nrPDB 189 2e-48 5UJU-A nrPDB 175 4e-44 5J7I-A nrPDB 171 9e-43 3K9D-A nrPDB 166 3e-41 Sequences not found previously or not previously below threshold: 3MY7-A nrPDB 149 3e-36 5JFN-A nrPDB 146 3e-35 1O20-A nrPDB 119 3e-27 4GHK-A nrPDB 95 6e-20 4JBE-A nrPDB 77 2e-14 1VLU-A nrPDB 76 4e-14 2H5G-A nrPDB 73 3e-13 4YIF-A nrPDB 33 0.28 6MFV-A nrPDB 32 0.63 2WVR-A nrPDB 32 0.63 5A0V-A nrPDB 32 0.86 4X6G-A nrPDB 31 0.98 3OD1-A nrPDB 31 0.98 3WHK-A nrPDB 31 1.0 6AHD-9 nrPDB 31 1.1 3BA0-A nrPDB 31 1.2 1JIZ-A nrPDB 31 1.4 3TFC-A nrPDB 31 1.5 4DYO-A nrPDB 31 1.8 5EQT-A nrPDB 31 1.8 2CUN-A nrPDB 30 2.0 3LOO-A nrPDB 30 3.0 1FBL-A nrPDB 30 3.1 5J6F-A nrPDB 30 3.2 3DOD-A nrPDB 30 3.2 2R6F-A nrPDB 30 3.3 4N4Q-A nrPDB 29 4.4 5C8D-A nrPDB 29 4.6 3UX8-A nrPDB 29 5.0 5C8A-A nrPDB 29 5.6 5XM3-A nrPDB 29 5.8 2ZDS-A nrPDB 29 6.1 3TW5-A nrPDB 29 6.2 1J3N-A nrPDB 28 8.0 3UWD-A nrPDB 28 9.2 6EVG-A nrPDB 28 9.6 >2W8P-A nrPDB Length = 487 Score = 647 bits (1670), Expect = 0.0, Method: Composition-based stats. Identities = 486/487 (99%), Positives = 486/487 (99%) Query: 49 GRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 108 GRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA Sbjct: 1 GRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 60 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 168 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS Sbjct: 61 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 120 Query: 169 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK Sbjct: 121 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 180 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT Sbjct: 181 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 240 Query: 289 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT VCSNQFLV Sbjct: 241 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLV 300 Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT Sbjct: 301 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 360 Query: 409 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG Sbjct: 361 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 420 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK Sbjct: 421 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 480 Query: 529 YVCYGGL 535 YVCYGGL Sbjct: 481 YVCYGGL 487 >5AC2-A nrPDB Length = 501 Score = 637 bits (1644), Expect = 0.0, Method: Composition-based stats. Identities = 167/484 (34%), Positives = 254/484 (52%), Gaps = 12/484 (2%) Query: 55 SAALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC-- 110 + T F+ W + + FPV +PA+ L V + + AV+AA +AF Sbjct: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIG 74 Query: 111 -RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFS 168 WR + A ER LL K +L+ +++ LA + + GK A+ ++ L + + Sbjct: 75 SPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCA 134 Query: 169 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 A ++ G I + +PIGV I PWNFP M+ K+G AL+ G TVVVK Sbjct: 135 GWADKIQGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 PAE TP +AL +A L +AG P GV N++P G AI + + K++FTGST Sbjct: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGY---GPTAGAAISSHMDIDKVAFTGSTEV 250 Query: 289 GKILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347 GK++ A ++KRV++ELGG +P IV A++D AV A F + GQ C+ +++ Sbjct: 251 GKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIF 310 Query: 348 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 407 V+ I+D FV+ E KK + +GN G TQGP I+++ +K+ + +GA + Sbjct: 311 VEESIYDEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 Query: 408 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467 GG F +PT+ NVT +M EE FGP+ ++KF + ++ I AN GL+ Sbjct: 370 CGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 +++D + ++ L+ G V VN + S +CPFGG K SG GRE +YG EY E+ Sbjct: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 Query: 528 KYVC 531 K V Sbjct: 490 KTVT 493 >5AC0-A nrPDB Length = 501 Score = 634 bits (1636), Expect = 0.0, Method: Composition-based stats. Identities = 169/479 (35%), Positives = 250/479 (52%), Gaps = 12/479 (2%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC---RWREV 115 T F+ W + + FPV +PA+ L V + + AV+AA +AF WR + Sbjct: 21 TKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEARRV 174 A ER LL K +L+ +++ LA + GK A+ ++ L + + A ++ Sbjct: 81 DASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKI 140 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 G I + +P+GV I PWNFP M K+G AL+ G TVVVKPAE TP Sbjct: 141 QGRTIPMDG-NFFTYTRSEPVGVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTP 199 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 +AL + L +AG P GV N++P G AI + V K++FTGST GK++ Sbjct: 200 LTALHMGSLIKEAGFPPGVVNIVPGY---GPTAGAAISSHMDVDKVAFTGSTEVGKLIKE 256 Query: 295 HAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 A ++KRVS+ELGG +P IVF A++D AV A F + GQ C+ +++ V+ I+ Sbjct: 257 AAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIY 316 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D FV+ E KK + +GN G +QGP I+++ EK+ + +GA + GG Sbjct: 317 DEFVRRSVERAKKYV-LGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAKLECGGGPW 375 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 F +PT+ +VT DM EE FGP+ ++KF + ++ I AN GL+ ++ Sbjct: 376 GNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTN 435 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 D + V+ L+ G V VN + S +CPFGG K SG GRE +YG EY E+K V Sbjct: 436 DIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTI 494 >4X2Q-A nrPDB Length = 504 Score = 623 bits (1608), Expect = e-179, Method: Composition-based stats. Identities = 169/485 (34%), Positives = 255/485 (52%), Gaps = 12/485 (2%) Query: 54 LSAALLRTDSFVGGRWL--PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC- 110 + + T F+ W + FPV +PA+G + V + + AV+AA AF Sbjct: 17 PNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSL 76 Query: 111 --RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWF 167 WR + A ER LL K +L+ +++ LA + + GKP +A + ++ ++ Sbjct: 77 GSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYY 136 Query: 168 SEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVV 227 + A +++G I D +PIGV I PWNFP M K+ AL G TVV+ Sbjct: 137 AGWADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVI 195 Query: 228 KPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287 KPAE TP SAL + L +AG P GV N++P G AI + + KI+FTGST Sbjct: 196 KPAEQTPLSALYMGALIKEAGFPPGVINILPGY---GPTAGAAIASHIGIDKIAFTGSTE 252 Query: 288 TGKILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQF 346 GK++ A ++KRV++ELGG +P I+F A++D AV A F N GQ C ++ Sbjct: 253 VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRI 312 Query: 347 LVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATV 406 V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + + V++GA + Sbjct: 313 FVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 371 Query: 407 VTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGL 466 GGK F EPT+ NVT DM EE FGP+ +++F T +E I AN +D GL Sbjct: 372 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 431 Query: 467 AGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLE 526 ++ D + V+ ++ G V +N + + PFGG K SG GRE ++G+ EY E Sbjct: 432 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 491 Query: 527 LKYVC 531 +K V Sbjct: 492 VKTVT 496 >5FHZ-A nrPDB Length = 529 Score = 615 bits (1587), Expect = e-176, Method: Composition-based stats. Identities = 167/479 (34%), Positives = 252/479 (52%), Gaps = 12/479 (2%) Query: 61 TDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115 T F+ W + F +P++ + V + + AV AA AF R WR + Sbjct: 49 TKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRL 108 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEARRV 174 A R LL + +L+ +++ LA + T ++GKP A ++ L +F+ A ++ Sbjct: 109 DALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKI 168 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 G I T + +PIGV ITPWNFP M+ K+ AL G T+V+KPAE TP Sbjct: 169 QGKTIPTD-DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTP 227 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 +AL L L +AG P GV N++P VG AI + P ++KI+FTGST GK++ Sbjct: 228 LTALYLGSLIKEAGFPPGVVNIVPGF---GPTVGAAISSHPQINKIAFTGSTEVGKLVKE 284 Query: 295 HAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 A+ ++KRV++ELGG P IV A++D AV A F N GQ C +++ V+ ++ Sbjct: 285 AASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVY 344 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 FV+ E KK VG+ F+ T QGP I++K +K+ + + +GA + GG Sbjct: 345 SEFVRRSVEYAKKR-PVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAM 403 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + F +PT+ VT +M EE FGP+ P++KF + EE I AN+ D GL +++ Sbjct: 404 EDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTK 463 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 + + ++A LE G V +N + PFGG K SG GRE +Y + EY E+K V Sbjct: 464 NLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTI 522 >5L13-A nrPDB Length = 517 Score = 614 bits (1583), Expect = e-176, Method: Composition-based stats. Identities = 172/517 (33%), Positives = 265/517 (51%), Gaps = 22/517 (4%) Query: 23 RLRPRAGG-LVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQ 79 R PR G L+ A+ PA + + F+ W A + TFP Sbjct: 7 RFGPRLGRRLLSAAATQAVPAPNQQP---------EVFCNQIFINNEWHDAVSRKTFPTV 57 Query: 80 DPASGAALGMVADCGVREARAAVRAAYEAFC---RWREVSAKERSSLLRKWYNLMIQNKD 136 +P++G + VA+ + AV+AA AF WR + A R LL + +L+ +++ Sbjct: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117 Query: 137 DLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPI 195 LA + T ++GKP ++ ++ L +++ A + +G I D + +P+ Sbjct: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDG-DFFSYTRHEPV 176 Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 GV I PWNFP M K+G ALA G VV+K AE TP +AL +A L +AG P GV N Sbjct: 177 GVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVN 236 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN-SVKRVSMELGGLAPFI 314 ++P G AI + V K++FTGST G+++ A + ++KRV++ELGG +P I Sbjct: 237 IVPGF---GPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNI 293 Query: 315 VFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGF 374 + A++D AV A + F N GQ C ++ VQ I+D FV+ A K+ VGN F Sbjct: 294 IMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSV-ARAKSRVVGNPF 352 Query: 375 EEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 434 + T QGP ++E +K+ +N +GA ++ GG F +PT+ +V M Sbjct: 353 DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTI 412 Query: 435 THEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNE 494 EE FGP+ ++KF T EE + AN + GLA +++D + +++ L+ G V VN Sbjct: 413 AKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNC 472 Query: 495 GLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + + PFGG K SG GRE +YG+ Y E+K V Sbjct: 473 YDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVT 509 >1O9J-A nrPDB Length = 501 Score = 613 bits (1582), Expect = e-176, Method: Composition-based stats. Identities = 170/481 (35%), Positives = 253/481 (52%), Gaps = 12/481 (2%) Query: 58 LLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC---RW 112 + T F+ W + + TFPV +PA+ + V + + AV+AA EAF W Sbjct: 18 IQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDVDKAVKAAREAFQMGSPW 77 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEA 171 R + A ER L+ K +L+ +++ LA + + +GK A+ ++ Y L + + A Sbjct: 78 RTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYLMDLDYCIKALRYCAGWA 137 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 ++ G I + + +PIGV +I PWN P ++ K+G AL G TV+VKPAE Sbjct: 138 DKIQGRTIPVDG-EFFSYTRHEPIGVCGLIFPWNAPMILLACKIGPALCCGNTVIVKPAE 196 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 TP +AL +A L +AG P GV N++P G AI + V K++FTGST GK+ Sbjct: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGY---GPTAGAAISSHMDVDKVAFTGSTEVGKM 253 Query: 292 LLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 + AA ++KRV++ELG P IVF A++D AV A F N GQ+C+ +++ V+ Sbjct: 254 IQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQGQSCIAASKLFVEE 313 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I+D FV+ E KK + GN G GP IN+ K+ + + +GA + GG Sbjct: 314 AIYDEFVQRSVERAKKYV-FGNPLTPGVNHGPQINKAQHNKIMELIESGKKEGAKLECGG 372 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 F +PT+ NVT DM EE FGP+ ++KF + +E I AN GL Sbjct: 373 GPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYGLVAGV 432 Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +++D + V+ L+ G V VN L +S + P GG K SG GRE +YGI EY E+K V Sbjct: 433 FTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGEYGIHEYTEVKTV 492 Query: 531 C 531 Sbjct: 493 T 493 >1AG8-A nrPDB Length = 499 Score = 609 bits (1570), Expect = e-174, Method: Composition-based stats. Identities = 163/485 (33%), Positives = 251/485 (51%), Gaps = 12/485 (2%) Query: 56 AALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC--- 110 +L F+ W A + TFP +P++G + VA+ + AV+AA AF Sbjct: 14 PEVLYNQIFINNEWHDAVSKKTFPTVNPSTGDVICHVAEGDKADVDRAVKAARAAFQLGS 73 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSE 169 WR + A ER LL + +L+ +++ LA + T ++GKP ++ ++ L +++ Sbjct: 74 PWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYIISYLVDLDMVLKCLRYYAG 133 Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 A + +G I D + +P+GV I PWNFP M K+G ALA G VV+K Sbjct: 134 WADKYHGKTIPIDG-DYFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKV 192 Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289 AE TP +AL +A L +AG P GV NVIP G AI + V K++FTGST G Sbjct: 193 AEQTPLTALYVANLIKEAGFPPGVVNVIPGF---GPTAGAAIASHEDVDKVAFTGSTEVG 249 Query: 290 KILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348 ++ A ++KRV++E+GG +P I+ A++D AV A + F N GQ C ++ V Sbjct: 250 HLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFV 309 Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 Q I+ FV+ A K+ VGN F+ T QGP ++E +KV + +G ++ Sbjct: 310 QEDIYAEFVERSV-ARAKSRVVGNPFDSRTEQGPQVDETQFKKVLGYIKSGKEEGLKLLC 368 Query: 409 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 GG F +PT+ ++ M EE FGP+ ++KF + EE + AN + GLA Sbjct: 369 GGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKSMEEVVGRANNSKYGLAA 428 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 +++D + +++ L+ G V VN + + PFGG K SG GRE +YG+ Y E+K Sbjct: 429 AVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKLSGSGRELGEYGLQAYTEVK 488 Query: 529 YVCYG 533 V Sbjct: 489 TVTVR 493 >3JZ4-A nrPDB Length = 481 Score = 604 bits (1558), Expect = e-173, Method: Composition-based stats. Identities = 267/481 (55%), Positives = 352/481 (73%), Gaps = 6/481 (1%) Query: 55 SAALLRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRW 112 + L R + + G WL A V +PA+G LG V G E RAA+ AA A W Sbjct: 4 DSNLFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRALPAW 63 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR 172 R ++AKER+++LR W+NLM++++DDLAR++T E GKPL EA GEI Y+A F+EWF+EE + Sbjct: 64 RALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAEEGK 123 Query: 173 RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 R+YGD I D+R +V+KQPIGV A ITPWNFP+AMITRK G ALAAGCT+V+KPA Sbjct: 124 RIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQ 183 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 TPFSALALAELA +AG+P+GV+NV+ S A VG + ++PLV K+SFTGST G+ L Sbjct: 184 TPFSALALAELAIRAGVPAGVFNVVTGS---AGAVGNELTSNPLVRKLSFTGSTEIGRQL 240 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + A +K+VS+ELGG APFIVFD A++D+AV GA+ASKFRN GQTCVC+N+ VQ G+ Sbjct: 241 MEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGV 300 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 +D F + +AM K L +G+G + G T GPLI+EKAV KVE+ + DA+ KGA VV GGK Sbjct: 301 YDRFAEKLQQAMSK-LHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKA 359 Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 H+ G NFF+PT+L +V + + EETFGPLAP+ +F E + IA AN + GLA YFY+ Sbjct: 360 HERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYA 419 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 +D ++++RV E LE G+VG+N G+IS+ PFGG+K SGLGREGSKYGI++YLE+KY+C Sbjct: 420 RDLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCI 479 Query: 533 G 533 G Sbjct: 480 G 480 >5GT6-A nrPDB Length = 508 Score = 603 bits (1556), Expect = e-173, Method: Composition-based stats. Identities = 171/474 (36%), Positives = 267/474 (56%), Gaps = 10/474 (2%) Query: 62 DSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC--RWREVSA 117 F+ G ++ A TF +PA+ L +V + + AAV+AA AF W E++ Sbjct: 35 KMFINGEFVSAIGGKTFETYNPATEDVLAVVCEAQEEDIDAAVKAARSAFESGPWAEMTT 94 Query: 118 KERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGE-ILYSAFFLEWFSEEARRVYG 176 ER+ L+ K +L+ +++++LA++ ++GKP + A + I + +++ ++ G Sbjct: 95 AERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALDDDISATVENYRYYAGWTTKIIG 154 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 I +KD +P+GV I PWNFP M + K+GAALA GCT+V+KPAE TP S Sbjct: 155 QTIPI-SKDYLNYTRHEPVGVVGQIIPWNFPLVMSSWKMGAALATGCTIVLKPAEQTPLS 213 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 L A+L +AG P+GV N +P E G AI + K++FTGST TGK ++ + Sbjct: 214 LLYAAKLFKEAGFPNGVVNFVPGF---GPEAGAAIVNHHDIDKVAFTGSTVTGKYIMRQS 270 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A +K V++ELGG +P I+ + A++++A+ GA N GQ C ++ V R ++ Sbjct: 271 AEMIKHVTLELGGKSPNIILEDADLEEAINGAFQGIMYNHGQNCSAGSRVFVHRKHYETV 330 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V A + M N+++G G E+ T GPL+++K E+V + +GATV GG+R Sbjct: 331 VDALVK-MANNVKLGAGMEKETEMGPLVSKKQQERVLNYIEQGKKEGATVAAGGERALEK 389 Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476 F +PT+ +VT DM EE FGP+ V+ FD+ EE I AN + GLA ++Q+ Sbjct: 390 GYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEEVIERANNSSYGLAAGVWTQNIK 449 Query: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +VA +L+ G V +N+ + + PFGG KQSG+GRE Y +D Y E+K V Sbjct: 450 TGHQVANKLKAGTVWINDYNLENAAAPFGGYKQSGIGRELGSYALDNYTEVKSV 503 >4V3F-A nrPDB Length = 497 Score = 601 bits (1550), Expect = e-172, Method: Composition-based stats. Identities = 167/480 (34%), Positives = 262/480 (54%), Gaps = 13/480 (2%) Query: 61 TDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVS 116 F+ G W PV +P++ +G + + AV AA AF R W S Sbjct: 8 RQLFIDGEWREPIKKNRIPVINPSTEEIIGDIPAATAEDVEVAVVAARRAFRRNNWSATS 67 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 R++ LR + + KD ++ T +SGKP EA +I A E+F+ +A + G Sbjct: 68 GAHRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEAVLDIDDVASCFEYFAGQAEALDG 127 Query: 177 DI---IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + P + ++ VL+QP+GV +I+PWN+P M T K+ ALAAGCT V+KP+E Sbjct: 128 KQKAPVTLPMERFKSHVLRQPLGVVGLISPWNYPLLMATWKIAPALAAGCTAVLKPSELA 187 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 + L E+ ++ G+P GV N++ + G + + P V KI+FTGS+ TG ++ Sbjct: 188 SVTCLEFGEVCNEVGLPPGVLNILTGL---GPDAGAPLVSHPDVDKIAFTGSSATGSKVM 244 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 AA VK V++ELGG +P +VF+ ++D+ V + F GQ C +++ LV I Sbjct: 245 ASAAQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCFWTNGQICSATSRLLVHESIA 304 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 FV + KN+++ + FEEG GP+I++ +K+ K ++ A S+GAT++ GG R Sbjct: 305 AEFVDKLVK-WTKNIKISDPFEEGCRLGPVISKGQYDKIMKFISTAKSEGATILYGGSRP 363 Query: 414 QL--GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 + + EPT++ +++ M EE FGP+ V F +E+EAIA+AN + GLA + Sbjct: 364 EHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSEDEAIALANDTEYGLAAAVF 423 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 S D + R+ + LEVG V VN V+ P+GG+K+SG GRE ++GI YL +K V Sbjct: 424 SNDLERCERITKALEVGAVWVNCSQPCFVQAPWGGIKRSGFGRELGEWGIQNYLNIKQVT 483 >4MPY-A nrPDB Length = 520 Score = 591 bits (1525), Expect = e-169, Method: Composition-based stats. Identities = 167/481 (34%), Positives = 277/481 (57%), Gaps = 12/481 (2%) Query: 58 LLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC--RWR 113 L ++ G W+ +A T + +P + + V++ +A A+ AA AF W Sbjct: 30 HLSQRQYIDGEWVESANKNTRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGEWS 89 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 + +A+ R +R + + ++++ LAR+ T ++GK L+E++ ++ +F+ A + Sbjct: 90 QETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHNVFMYFAGLADK 149 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 G++I +P D + ++K+P+GV ITPWN+P + K+ ALA GC++V+KP+E T Sbjct: 150 DGGEMIDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEIT 209 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P + + + EL + G P G N+I + EVG+ + V +SFTG TGK ++ Sbjct: 210 PLTTIRVFELMEEVGFPKGTINLILGA---GSEVGDVMSGHKEVDLVSFTGGIETGKHIM 266 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 +AAN+V +++ELGG P I+FD A+ + AV A+ + + GQ C ++ LVQ I Sbjct: 267 KNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSIK 326 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D F +A + +KK +++GNGF+ T GP+I+ + K+E ++ A ++GAT+ GGKR Sbjct: 327 DKFEQALIDRVKK-IKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKRP 385 Query: 414 QL----GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 FFEPT++ N M EE FGP+ V F+TE+EAI +AN + GLAG Sbjct: 386 DRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAGA 445 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 +S+D + RVA +L++G V +N+ + P+GG KQSG+GRE K G++EYL K+ Sbjct: 446 VFSKDIGKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEYLVSKH 505 Query: 530 V 530 + Sbjct: 506 I 506 >4O6R-A nrPDB Length = 496 Score = 580 bits (1496), Expect = e-166, Method: Composition-based stats. Identities = 162/487 (33%), Positives = 263/487 (54%), Gaps = 12/487 (2%) Query: 51 LAGLSAALLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 108 +A ++T F+ GR++ A T V +P G+ + +A + AV AA A Sbjct: 1 MAHHHHHHMQTQLFIDGRFVDAVDRGTIDVLNPHDGSVITKIAAATAADVDLAVDAATRA 60 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWF 167 F W + A ER LL + + + N + LA++ + ++G P++++ ++ +A +F Sbjct: 61 FPAWSAMPAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRALDVPRTAACFRYF 120 Query: 168 SEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVV 227 A ++ G +I V + PIGV I PWNFP + K+G ALAAG TVV+ Sbjct: 121 GGMADKLQGSVIPVDT-GFLNYVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVL 179 Query: 228 KPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287 KP+E TP S L + EL ++ G P+GV N++P G+ + P V KI+FTGST Sbjct: 180 KPSEITPLSTLRIVELMAEVGFPAGVVNIVPGY---GHTAGQRLAEHPGVGKIAFTGSTA 236 Query: 288 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347 TG+ ++ + ++KRV +ELGG IVFD AN+D A+ GA + F N GQ C+ ++ + Sbjct: 237 TGRRIVEASQGNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLV 296 Query: 348 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 407 + I DAF++ F A+ ++R+GN + T GPL +++ +++V V+ A +G V+ Sbjct: 297 LHERIADAFLERFV-ALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVL 355 Query: 408 TGGKRHQLG----KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 TGG Q + PT++ EE FGP V++F +++EA+AIANA + Sbjct: 356 TGGSAPQDPALANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATE 415 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 523 GL ++ D ++ R+A +++ GM +N + PFGGV +SG GRE + + Sbjct: 416 YGLGSGLWTNDLSRAHRMAARIDAGMCWINCYKRVNPGSPFGGVGKSGYGREMGFEAMHD 475 Query: 524 YLELKYV 530 Y E + V Sbjct: 476 YTEARSV 482 >4PXL-B nrPDB Length = 517 Score = 579 bits (1493), Expect = e-165, Method: Composition-based stats. Identities = 179/505 (35%), Positives = 274/505 (54%), Gaps = 16/505 (3%) Query: 33 PASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLP--AAATFPVQDPASGAALGMV 90 P S A G ++ G + T F+ G+++ + TF +DP +G + + Sbjct: 14 PNSATANGSSK-----GSFEVPKVEVRFTKLFIDGKFVDAVSGKTFETRDPRTGEVIASI 68 Query: 91 ADCGVREARAAVRAAYEAFC--RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGK 148 A+ + AV+AA EAF W ++ ER +L ++ +L+ ++ ++LA + T ++GK Sbjct: 69 AEGDKADVDLAVKAAREAFDNGPWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGK 128 Query: 149 PLKEAHG-EILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFP 207 +I +A L +++ A +V+G + A+ LK+P+GV I PWN+P Sbjct: 129 LFAVGKARDIPGAAHLLRYYAGAADKVHGATLKM-AQRMHGYTLKEPVGVVGHIVPWNYP 187 Query: 208 SAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEV 267 + M KVG ALAAGC VVVKPAE TP SAL A LA +AG+P+GV NV+P Sbjct: 188 TTMFFFKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGF---GPTA 244 Query: 268 GEAICTDPLVSKISFTGSTTTGKILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVA 326 G A+ V K+SFTGST G++++ AA ++K VS+ELGG +P IVFD A++D AV Sbjct: 245 GAAVAAHMDVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVN 304 Query: 327 GAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINE 386 + + N G+ CV + VQ GI+D FVK AE K++ VG+ F +QGP +++ Sbjct: 305 LVNFATYTNKGEICVAGTRIYVQEGIYDEFVKKAAELASKSV-VGDPFNPSVSQGPQVDK 363 Query: 387 KAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPV 446 EKV + ++ +GAT+VTGGK + EPT+ +V DM +E FGP+ + Sbjct: 364 DQYEKVLRYIDIGKREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMAL 423 Query: 447 IKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGG 506 +KF T EE I AN GLA +++ V+ + G + +N + PFGG Sbjct: 424 MKFKTVEEVIQKANNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWINCYFAFDPDAPFGG 483 Query: 507 VKQSGLGREGSKYGIDEYLELKYVC 531 K SG G++ +D+YL+ K V Sbjct: 484 YKMSGFGKDMGMDALDKYLQTKTVV 508 >4CAZ-A nrPDB Length = 490 Score = 575 bits (1483), Expect = e-164, Method: Composition-based stats. Identities = 162/479 (33%), Positives = 263/479 (54%), Gaps = 13/479 (2%) Query: 60 RTDSFVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSA 117 ++GGR++ + ATF +PA+G L V + AV++A E W ++A Sbjct: 6 EQKLYIGGRYVEASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKVWAAMTA 65 Query: 118 KERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYG 176 +RS +LR+ +++ + D+LA + T ++GKPL E +I+ A LE+++ + G Sbjct: 66 MQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEG 125 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 + I + ++P+GV A I WN+P + K ALAAG ++ KP+E TP + Sbjct: 126 EQIPL-RETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLT 184 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 AL LAE+ ++AG+P GV+NV+ S +EVG+ + PL+ KISFTG T+TGK ++ A Sbjct: 185 ALKLAEIYTEAGVPDGVFNVLTGS---GREVGQWLTEHPLIEKISFTGGTSTGKKVMASA 241 Query: 297 ANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 ++S +K V+MELGG +P I+F A++D+A A+ + F ++GQ C + + R Sbjct: 242 SSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQAR 301 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415 F E +++ +R+G+ +E T GPL++ +E V + ++ A ++ GG+R Sbjct: 302 FEAKVLERVQR-IRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTD 360 Query: 416 G----KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 G + PT+ + DM EE FGP+ ++ +D E+EAI AN + GLA Sbjct: 361 GAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVV 420 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +QD A+ R +LE G+ +N S E P GG KQSG+GRE + Y +K V Sbjct: 421 TQDLARAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSV 479 >4PZ2-A nrPDB Length = 534 Score = 574 bits (1480), Expect = e-164, Method: Composition-based stats. Identities = 178/485 (36%), Positives = 276/485 (56%), Gaps = 14/485 (2%) Query: 56 AALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC--R 111 + T F+ G ++ A + TF +DP +G + VA+ + AVRAA AF Sbjct: 46 PEIRFTKLFINGSFVDAVSGRTFDTRDPRTGGVIASVAEADKEDVDLAVRAARAAFDHGE 105 Query: 112 WREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGK-PLKEAHGEILYSAFFLEWFSEE 170 W +S ER ++ + +L+ ++ +LA + + ++GK P ++ +A L +F+ Sbjct: 106 WPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDVGNAAGSLRYFAGA 165 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 A +++G+ + P + + L++P+GVA VI PWNFPS M KV ALAAGC +VVKPA Sbjct: 166 ADKIHGETLKMPGQ-FQGHTLREPLGVAGVIIPWNFPSTMFAVKVAPALAAGCALVVKPA 224 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E TP SAL LA+LA QAG+P GV NV+P G A+ + V +SFTGST G+ Sbjct: 225 EQTPLSALYLAQLAKQAGVPDGVINVVPGF---GPTAGAALASHMDVDMVSFTGSTEVGR 281 Query: 291 ILLHHAAN-SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 +++ +A ++K V +ELGG +P IVFD A++D AV A+ + F N G+ CV +++ VQ Sbjct: 282 LIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNKGEACVAASRVYVQ 341 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGF-EEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 ++D F + AE M ++ VG+ F + QGP +++ E+V ++ +GAT++T Sbjct: 342 ERVYDRFEERLAERM-RSWVVGDPFSDPRADQGPQVDKAQYERVLSYIDHGKREGATLLT 400 Query: 409 GGKR--HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGL 466 GG+ + + EPT+ NV +DM+ EE FGP+ ++KF T EEAIA AN GL Sbjct: 401 GGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVEEAIARANDTRYGL 460 Query: 467 AGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLE 526 ++D RV + G+V VN +CPFGG K SG G++ + +D+YL Sbjct: 461 GAGVVTRDLDVANRVVRSVRAGVVWVNCYFAMGSDCPFGGRKMSGFGKDEGMHALDKYLA 520 Query: 527 LKYVC 531 +K V Sbjct: 521 VKSVV 525 >3IWK-A nrPDB Length = 503 Score = 572 bits (1475), Expect = e-163, Method: Composition-based stats. Identities = 162/485 (33%), Positives = 257/485 (52%), Gaps = 16/485 (3%) Query: 60 RTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR-----W 112 F+ G W P +P++ +G + + AV AA A R W Sbjct: 7 SRQLFIDGEWRVPILNKRIPNINPSTENIIGDIPAATKEDVDLAVDAAKRAISRKNGRDW 66 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR 172 S R+ LR + + KD+L ++ + + GKPL+EA ++ E+++ A Sbjct: 67 SAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEALADLDDVVACFEYYAGLAE 126 Query: 173 RVYGDI---IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 + I P ++ +LK+PIGV A+ITPWN+P M T K+ ALAAGC ++KP Sbjct: 127 ELDSKQKAPISLPMDTFKSYILKEPIGVVALITPWNYPFLMATWKIAPALAAGCAAILKP 186 Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289 +E + L L E+ + G+P GV N++ E G ++ + P V KISFTGS+ TG Sbjct: 187 SELASVTCLELGEICKEVGLPRGVLNIVTGL---GHEAGASLASHPDVDKISFTGSSATG 243 Query: 290 KILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 ++ AA VK VS+ELGG +P +VF+ ++D+ + F GQ C +++ +V Sbjct: 244 SKIMTTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEWTVFGCFFTNGQICSATSRLIVH 303 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 I FV + +N+++ + EEG GP+++E +KV ++ A S+GAT++TG Sbjct: 304 ESIAVEFVDKLVK-WAENIKISDPLEEGCRLGPIVSEAQYKKVLNCISSAKSEGATILTG 362 Query: 410 GKRHQL--GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467 G+R + F EPT++ +VT M EE FGP+ V F TEEEAI +AN GL Sbjct: 363 GRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFSTEEEAINLANDTHYGLG 422 Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 S D + R+++ L+ G+V +N S ++ P+GG+K+SG GRE ++G++ YL + Sbjct: 423 SAVMSNDLERCERLSKALQAGIVWINCAQPSFIQAPWGGIKRSGFGRELGEWGLENYLSV 482 Query: 528 KYVCY 532 K V Sbjct: 483 KQVTR 487 >1BPW-A nrPDB Length = 503 Score = 570 bits (1469), Expect = e-163, Method: Composition-based stats. Identities = 167/478 (34%), Positives = 256/478 (53%), Gaps = 15/478 (3%) Query: 63 SFVGGRWL---PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKE 119 ++ GGR + A T PV +PA+G L + CG E AV++A A+ +W +++ E Sbjct: 22 NYWGGRRIKSKDGATTEPVFEPATGRVLCQMVPCGAEEVDQAVQSAQAAYLKWSKMAGIE 81 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII 179 RS ++ + ++ + +D++A++ +GK + EA +I + +E+++ A + G I Sbjct: 82 RSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEYDIDAAWQCIEYYAGLAPTLSGQHI 141 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 P A ++P+GV A I WN+P + K ALA G VV KP+ TP + + Sbjct: 142 QLPG-GAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVTGVI 200 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 LAE+ +AG+P G+ NV+ + E G +C P V+K+SFTGS TGK ++ +A + Sbjct: 201 LAEIFHEAGVPVGLVNVV----QGGAETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKT 256 Query: 300 VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKA 359 VK V++ELGG +P ++F ++ AV GA+ + F GQ C + VQR I F++ Sbjct: 257 VKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEE 316 Query: 360 FAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG--- 416 + K + VG+ T G LI++ ++KV V A +GA V+ GG+ Sbjct: 317 VVKR-TKAIVVGDPLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPK 375 Query: 417 ---KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 F P +L N DM C EE FGP+ V+ FDTEEE + AN GLA +++ Sbjct: 376 LKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTR 435 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 D ++ RVA LE G +N IS VE PFGG K SG GRE + +D Y +LK V Sbjct: 436 DISRAHRVAANLEAGTCYINTYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVI 493 >4V6H-A nrPDB Length = 484 Score = 569 bits (1466), Expect = e-162, Method: Composition-based stats. Identities = 270/488 (55%), Positives = 353/488 (72%), Gaps = 9/488 (1%) Query: 46 CYAGRLAGLSAALLRTDSFVGGRWL--PAAATFPVQDPASGAALGMVADCGVREARAAVR 103 +LLR +++GG W + ATF V DPA+G +LG V G E A+ Sbjct: 1 GPGSM---KDPSLLRHQAYIGGEWQAADSDATFEVFDPATGESLGTVPKMGAAETARAIE 57 Query: 104 AAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFF 163 AA A+ WR +AKER+++LR+W++L+I N DDLA I+T E GKPL EA GEI Y+A F Sbjct: 58 AAQAAWAGWRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEAKGEIAYAASF 117 Query: 164 LEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGC 223 +EWF+EE +RV GD + TP ++R +V+K+PIGV A ITPWNFP+AMI RKVG ALAAGC Sbjct: 118 IEWFAEEGKRVAGDTLPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGC 177 Query: 224 TVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFT 283 +VVKPAE TPFSALA+A LA +AG+P GV +V+ + K +G I ++P+V K+SFT Sbjct: 178 PIVVKPAESTPFSALAMAFLAERAGVPKGVLSVVIG---DPKAIGTEITSNPIVRKLSFT 234 Query: 284 GSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCS 343 GST G++L+ +A +VK++++ELGG APFIVFD A++D AV GA+ASK+RN GQTCVC+ Sbjct: 235 GSTAVGRLLMAQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCT 294 Query: 344 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 403 N+F V ++DAF A A+ K L+VG G E G T GPLINE AV+KVE + DA++KG Sbjct: 295 NRFFVHERVYDAFADKLAAAVSK-LKVGRGTESGATLGPLINEAAVKKVESHIADALAKG 353 Query: 404 ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 A+++TGGKRH LG FFEPT+L V DM EETFGPLAP+ +F +EEE + +AN + Sbjct: 354 ASLMTGGKRHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTE 413 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 523 GLA Y YS+D ++WRVAE LE GMVG+N GLIS+ PFGGVKQSGLGREGS YGID+ Sbjct: 414 FGLAAYLYSRDIGRVWRVAEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDD 473 Query: 524 YLELKYVC 531 Y+ +KY+C Sbjct: 474 YVVIKYLC 481 >6QAO-A nrPDB Length = 508 Score = 568 bits (1464), Expect = e-162, Method: Composition-based stats. Identities = 161/478 (33%), Positives = 251/478 (52%), Gaps = 15/478 (3%) Query: 63 SFVGGRWL---PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKE 119 ++ GG + A+ T +PA+G + G +E AV+ A AF W + S E Sbjct: 27 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 86 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII 179 R +L + ++ + +D++A + +GK + EA +I S LE+++ A + G+ I Sbjct: 87 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 146 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 P ++P+GV I WN+P + + K ALA G +V KP+ TP SAL Sbjct: 147 QLPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 205 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 LAE+ S+AG+P G++NV+ + G+ +C P V+K+SFTGS TG ++ +A Sbjct: 206 LAEIYSEAGVPPGLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 261 Query: 300 VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKA 359 +K V++ELGG +P I+F +++ AV GA+ + F GQ C + VQ+ I D F + Sbjct: 262 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 321 Query: 360 FAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK------RH 413 + + +++G+ E T GPLIN +E+V V A +GA V+ GG Sbjct: 322 VVKQ-TQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 380 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + P +L N DM C EE FGP+ ++ FDTE E + AN GLA +++ Sbjct: 381 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 440 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 D + RV +L+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC Sbjct: 441 DIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 498 >3IWJ-A nrPDB Length = 503 Score = 565 bits (1457), Expect = e-161, Method: Composition-based stats. Identities = 168/483 (34%), Positives = 258/483 (53%), Gaps = 16/483 (3%) Query: 61 TDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF-----CRWR 113 F+ G W PV +PA+ +G + + AV AA A W Sbjct: 8 RQLFINGDWKAPVLNKRIPVINPATQNIIGDIPAATKEDVDVAVAAAKTALTRNKGADWA 67 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 S R+ LR + + K +LA++ + + GKPL EA +I A E++++ A + Sbjct: 68 TASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAWDIDDVAGCFEYYADLAEK 127 Query: 174 VYGDI---IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 + + P ++ VL++PIGV +ITPWN+P M T KV ALAAGC ++KP+ Sbjct: 128 LDARQKAPVSLPMDTFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAILKPS 187 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E + L L E+ + G+P GV N++ E G + T P V K++FTGS+ TG Sbjct: 188 ELASLTCLELGEICKEVGLPPGVLNILTGL---GPEAGAPLATHPDVDKVAFTGSSATGS 244 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 ++ AA VK VS+ELGG +P +VF+ ++D+A A+ F GQ C +++ ++ Sbjct: 245 KIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHE 304 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I F+ + + KN+++ + EEG GP+++E EK+ K V++A S+GAT++TGG Sbjct: 305 SIATEFLNRIVKWI-KNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGG 363 Query: 411 KRHQL--GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 R + F EPT++ +VT +M EE FGP+ V F TEEEAI +AN GL Sbjct: 364 SRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGA 423 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 S D + RV + + G+V VN + P+GGVK+SG GRE ++G+D YL +K Sbjct: 424 AVISNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSVK 483 Query: 529 YVC 531 V Sbjct: 484 QVT 486 >3EK1-A nrPDB Length = 504 Score = 564 bits (1454), Expect = e-161, Method: Composition-based stats. Identities = 266/492 (54%), Positives = 347/492 (70%), Gaps = 8/492 (1%) Query: 42 AQLRCYAGRLAGLSAALLRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREAR 99 AQ + LA +LL++ V GRW+ A T V +PA G+ +G V V + Sbjct: 14 AQTQGPGSMLALKDPSLLKSQCLVNGRWIDAADGTTIKVTNPADGSVIGTVPSLSVATIK 73 Query: 100 AAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILY 159 A+ A+ +A W +AKER+ +LRKW++L+I N DD+A I+T+E GKPL EA GE+LY Sbjct: 74 EAIDASAKALSGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEARGEVLY 133 Query: 160 SAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAAL 219 +A F+EWF+EEA+RVYGD I P +R V++QP+GV A ITPWNFP+AMITRK AL Sbjct: 134 AASFIEWFAEEAKRVYGDTIPAPQNGQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPAL 193 Query: 220 AAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSK 279 AAGCT++V+PA+ TP +ALAL LA +AGIP+GV ++ A+E+G + ++ V K Sbjct: 194 AAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTG---KAREIGAELTSNDTVRK 250 Query: 280 ISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 339 +SFTGST G++L+ A ++KR+S+ELGG APFIVFD A++D AV GAM SK+RN GQT Sbjct: 251 LSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKYRNAGQT 310 Query: 340 CVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDA 399 CVC+N+ VQRG++D F + A + K L+VGNG E G GP+I EKA+ KV+ + DA Sbjct: 311 CVCANRIYVQRGVYDKFAEKLAAKV-KELKVGNGTEPGVVIGPMIEEKAITKVKAHIEDA 369 Query: 400 VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 459 VSKGA ++TGGK +LG FFEP +L VT DML EETFGPLAP+ FDTEEE IA A Sbjct: 370 VSKGAKLITGGK--ELGGLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQA 427 Query: 460 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 519 N GLA YFY+++ ++ RV+E LE GMVG N GLIS+ PFGGVKQSGLGREGSKY Sbjct: 428 NDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEVAPFGGVKQSGLGREGSKY 487 Query: 520 GIDEYLELKYVC 531 GI+EYLE KY+C Sbjct: 488 GIEEYLETKYIC 499 >3RHO-A nrPDB Length = 517 Score = 562 bits (1449), Expect = e-160, Method: Composition-based stats. Identities = 163/487 (33%), Positives = 269/487 (55%), Gaps = 15/487 (3%) Query: 57 ALLRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--W 112 + F+GG ++ A + T+ +P G+ + V+ V + AV AA EAF W Sbjct: 33 LQMPYQLFIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLW 92 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEA 171 +++A++R LL + ++M Q++++LA I ++G A + S +F+ Sbjct: 93 GKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWC 152 Query: 172 RRVYGDIIH---TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 ++ G I L K+P+GV ++ PWN+P M++ K A LAAG TVV+K Sbjct: 153 DKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIK 212 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 PA+ TP +AL AEL +AGIP GV N++P S VG+ + P V KI FTGST Sbjct: 213 PAQVTPLTALKFAELTLKAGIPKGVVNILPGS---GSLVGQRLSDHPDVRKIGFTGSTEV 269 Query: 289 GKILLHHAA-NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347 GK ++ A ++VK+VS++LGG +P I+F ++++AV M+S F N G+ C+ + + Sbjct: 270 GKHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLF 329 Query: 348 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 407 V+ IH+ FV+ E ++K +++GN E T GP +E + K+ + V +GAT+V Sbjct: 330 VEESIHNQFVQKVVEEVEK-MKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLV 388 Query: 408 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF--DTEEEAIAIANAADVG 465 GG + FF+PT+ +V M EE+FGP+ + +F + ++ ANA + G Sbjct: 389 CGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFG 448 Query: 466 LAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYL 525 LA +++D + V+++L+ G V +N + V PFGG KQSG G++ + ++EYL Sbjct: 449 LASGVFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYL 508 Query: 526 ELKYVCY 532 +K V + Sbjct: 509 RIKTVTF 515 >2D4E-A nrPDB Length = 515 Score = 555 bits (1430), Expect = e-158, Method: Composition-based stats. Identities = 174/505 (34%), Positives = 270/505 (53%), Gaps = 25/505 (4%) Query: 47 YAGRLAGLSAALLR----------TDSFVGGRWLPA--AATFPVQDPASGAALGMVADCG 94 YA R+AG+S + F+ G ++P+ TFP DPA+ LG+ A G Sbjct: 3 YADRVAGISWETIEEVRRRLKERPALHFIAGEFVPSESGETFPSLDPATNEVLGVAARGG 62 Query: 95 VREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH 154 RE A +AA+EAF RW AKER L + L+ ++ D+LA + ++G+ L+ Sbjct: 63 EREVDRAAKAAHEAFQRWSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVR 122 Query: 155 GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRK 214 ++ +A +++E A D +D ++ P G +ITPWN P + T + Sbjct: 123 AQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWR 182 Query: 215 VGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTD 274 + ALA G TVV+KPAE +PF+A LAE+ +A +P GV+N++ +E G A+ Sbjct: 183 IAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGF---GEEAGAALVAH 239 Query: 275 PLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFR 334 PLV ++ TG T TGKI++ +AA+ +KR+S ELGG +P +VF A++++A+ + F Sbjct: 240 PLVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFS 299 Query: 335 NTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEK 394 G+ C S++ LV+ I + FV E + +RVG+ + T GPLI+ + +++V Sbjct: 300 FNGERCTASSRLLVEEKIFEDFVGKVVER-ARAIRVGHPLDPETEVGPLIHPEHLQRVLG 358 Query: 395 QVNDAVSKGATVVTGGKRHQLG--------KNFFEPTLLCNVTQDMLCTHEETFGPLAPV 446 V +GA ++ GG+R + N+ PT+ M EE FGP+ Sbjct: 359 YVEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVA 417 Query: 447 IKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGG 506 I F EEEA+ AN GLA Y +++D + R+A +LE GMV +N + + PFGG Sbjct: 418 IPFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGG 477 Query: 507 VKQSGLGREGSKYGIDEYLELKYVC 531 VK SG REG Y +D Y +LK + Sbjct: 478 VKGSGDRREGGTYALDFYTDLKTIA 502 >4GO4-A nrPDB Length = 495 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 163/479 (34%), Positives = 262/479 (54%), Gaps = 13/479 (2%) Query: 59 LRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 ++ ++ GR++ A T V P G+ + +A + AV AA AF W + Sbjct: 1 MQNQLYIDGRFVDAVAGGTIDVVSPHDGSLITRIAAAEAADVDLAVAAAKRAFPAWSALG 60 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175 A ER LL K + + + ++LA++ + +G P++++ G ++ +A +F A ++ Sbjct: 61 AAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACFRYFGGMADKIE 120 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G +I A V ++PIGV A I PWNFP + K+G ALAAG T+V+KP+E TP Sbjct: 121 GSVIPVDA-GFLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPL 179 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 S L + EL ++ G P GV NV+P G+A+ V KI+FTGST TG+ ++ Sbjct: 180 STLRIVELMTEVGFPKGVVNVVPGY---GHTAGQALAEHLDVGKIAFTGSTATGRRIVEA 236 Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 + +++KR+ +ELGG IVF+ AN++ AV GA + F N GQ C+ ++ ++ + I D Sbjct: 237 SKSNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQ 296 Query: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415 F++ F A+ K++R+G+ + T GPL + ++V ++ A+ +G V+ GGK Sbjct: 297 FLERFI-ALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDD 355 Query: 416 G----KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 + EPT++ QD EE FGP V++F ++EEA+AIAN + GL + Sbjct: 356 KALANGFYVEPTVVEAKPQD-RVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLW 414 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 +Q+ A+ ++A + GM +N S PFGGV QSG GRE I +Y E + V Sbjct: 415 TQNLARAHKMAHAIHAGMCWINCYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEARSV 473 >4I8Q-A nrPDB Length = 514 Score = 552 bits (1422), Expect = e-157, Method: Composition-based stats. Identities = 157/482 (32%), Positives = 255/482 (52%), Gaps = 14/482 (2%) Query: 60 RTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREV 115 R ++GG W P+ +PA+ +G + + AV AA +A R W Sbjct: 23 RRQLYIGGEWREPVKKNRIPIINPATEEIIGDIPAATAEDVDIAVEAARKAIARDDWGST 82 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVY 175 + +R+ LR +++ K LA + + +SGK L E+ ++ A E+++ A + Sbjct: 83 TGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESAADMDDVAGCFEYYAGLAEALD 142 Query: 176 GD---IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 ++ + ++ VL++P+GV +ITPWN+P M KV ALAAGC ++KP+E Sbjct: 143 SRRMTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPSEL 202 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 + L L E+ + G+PSG N++ E G + + P V KISFTGS TG + Sbjct: 203 ASITCLELGEICREIGLPSGALNILTGL---GPEAGGPLASHPHVDKISFTGSGPTGSKI 259 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSAN-VDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 + AA VK VS+ LGG +P +VFD + +D A + F NTGQ C +++ +VQ Sbjct: 260 MTAAAQLVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQEN 319 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 I AF+ + KN+++ + EE GP+++ EKV K +++A S+GAT++ GG+ Sbjct: 320 IASAFMDRLLK-WTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGATILCGGE 378 Query: 412 RHQL--GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 R Q + +PT++ +V M EE FGP+ V F TEE+AI +AN GL Sbjct: 379 RPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLGAA 438 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 S+D + R + + G++ +N + E P+GG K+SG GR+ K+G++ +L +K Sbjct: 439 VMSKDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWGLENFLNIKQ 498 Query: 530 VC 531 V Sbjct: 499 VT 500 >4I8P-A nrPDB Length = 520 Score = 547 bits (1411), Expect = e-156, Method: Composition-based stats. Identities = 170/483 (35%), Positives = 260/483 (53%), Gaps = 16/483 (3%) Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAA-----YEAFCRWR 113 FV G W P A PV +P + A +G + + AAV AA W Sbjct: 25 RQLFVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGRDWA 84 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEA-- 171 R+ LR +I+ K +LA++ + GKP EA ++ A E+F+++A Sbjct: 85 RAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQAEA 144 Query: 172 -RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 + + P + + + ++PIGV +ITPWN+P M T K+ ALAAGCT V+KP+ Sbjct: 145 LDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLKPS 204 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E + L LA++ + G+PSGV N++ + G + P V K++FTGS TGK Sbjct: 205 ELASVTCLELADICKEVGLPSGVLNIVTGL---GPDAGAPLSAHPDVDKVAFTGSFETGK 261 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 ++ AA VK V++ELGG +P +VFD ++D+AV + F GQ C +++ L+ Sbjct: 262 KIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHT 321 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I F + A KN++V + EEG GP+++E EK++K +++A S+GAT++TGG Sbjct: 322 KIAKKFNERMV-AWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGG 380 Query: 411 KRHQL--GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 R F EPT++ ++T M EE FGP+ V +F TE+EAI +AN GLAG Sbjct: 381 VRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAG 440 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 S D + R++E+++ G + VN + P+GG K+SG GRE + GID YL +K Sbjct: 441 AVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVK 500 Query: 529 YVC 531 V Sbjct: 501 QVT 503 >3R31-A nrPDB Length = 517 Score = 546 bits (1407), Expect = e-156, Method: Composition-based stats. Identities = 163/487 (33%), Positives = 253/487 (51%), Gaps = 14/487 (2%) Query: 51 LAGLSAALLRTDSFVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEA 108 +A A + F+ G ++ F PA+G + + A+ +A A Sbjct: 5 IATPLKAQPKASHFIDGDYVEDNTGTPFESIFPATGEMIAKLHAATPAIVERAIASAKRA 64 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWF 167 W +S R +L++ ++M + D L+ + T ++GKP++E + A E+F Sbjct: 65 QKEWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVADPTSGADAFEFF 124 Query: 168 SEEAR-RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVV 226 A + GD I P A + P+GV I WN+P + K AL AG +V Sbjct: 125 GGIAPSALNGDYI--PLGGDFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNAMV 182 Query: 227 VKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGST 286 KP+E+TP AL +AE+ +AG+P G++NVI + ++ G + P V+K+S TGS Sbjct: 183 FKPSENTPLGALKIAEILIEAGLPKGLFNVI----QGDRDTGPLLVNHPDVAKVSLTGSV 238 Query: 287 TTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQF 346 TG+ + AA +K V+MELGG +P IVFD A+++ AV GAM F ++GQ C + Sbjct: 239 PTGRKVAAAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRV 298 Query: 347 LVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATV 406 VQ+ F++ + + +G+ + T GPL+++ EKV + ++GAT+ Sbjct: 299 FVQKKAKARFLENLKRRTEAMI-LGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATL 357 Query: 407 VTGGKRHQ---LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 +TGG + +PT+ +VT DM EE FGP+ V+ FD E+E +A ANA + Sbjct: 358 ITGGGIPNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATE 417 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 523 GLAG ++ D A+ RV + LE G + +N + VE PFGG KQSG GRE S ++ Sbjct: 418 FGLAGGVFTADLARAHRVVDGLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAALEH 477 Query: 524 YLELKYV 530 Y ELK V Sbjct: 478 YSELKTV 484 >4QYJ-A nrPDB Length = 516 Score = 544 bits (1402), Expect = e-155, Method: Composition-based stats. Identities = 162/496 (32%), Positives = 255/496 (51%), Gaps = 16/496 (3%) Query: 49 GRLAGLSAALLRTDSFVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARAAVRAAY 106 L+ + L +GG+W+ + T V +PA+G L V D V + AAV +A Sbjct: 23 SSLSAIDGLRLPHQMLIGGQWVSAQSGKTLNVYNPATGDILTEVPDGDVEDVNAAVESAA 82 Query: 107 EAF--CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFF 163 WR + R +L + +L+ + D+LAR+ T +GK L + E+ SA + Sbjct: 83 ATLRSDTWRRMPPSARERILLRLADLLEVHGDELARLETLNNGKLLIYSKLMEVGASAQW 142 Query: 164 LEWFSEEARRVYGDIIHT-----PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAA 218 L + + A ++ G + P RA + P+GV A I PWNFP M K+ A Sbjct: 143 LRYMAGWATKLTGSTLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNFPLLMAVWKIAPA 202 Query: 219 LAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVS 278 LA G TVV+KPAE+TP +AL LAELA +AG+P+G NV+ + G+A+ P V+ Sbjct: 203 LACGNTVVLKPAEETPLTALRLAELAMEAGLPAGALNVVTG---RGETAGDALVRHPKVA 259 Query: 279 KISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQ 338 K++FTGST G+I+ S+K VS+ELGG +P IV + +A GA A+ F N GQ Sbjct: 260 KVAFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVLADCDPQEAAEGAAAAIFFNHGQ 319 Query: 339 TCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVND 398 C ++ V I++ ++ A + +++ VG+G E+G GP++++K E V + + + Sbjct: 320 VCTAGSRLYVHESIYEDVIQRLA-VIGESIVVGSGLEQGVHMGPMVSKKHHENVLRHIRN 378 Query: 399 AVSKGATVVTGG-KRHQLGKNFFEPTLLCNV-TQDMLCTHEETFGPLAPVIKFDTEEEAI 456 + GA ++ GG + F +PT+ N +D+ +E FGP+ F E + Sbjct: 379 GIEDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLLSQEVFGPVLVATPFSDIAEVV 438 Query: 457 AIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREG 516 AN + GL ++ D + R+ ++LE G V VN + PFGG K SG+GRE Sbjct: 439 NEANRSVYGLGASIWTNDLSAALRINDELEAGTVWVNTHNMVDPNLPFGGFKDSGVGREH 498 Query: 517 SKYGIDEYLELKYVCY 532 I+ Y + + Sbjct: 499 GAAAIEHYTTTRSLVI 514 >5J77-A nrPDB Length = 508 Score = 541 bits (1395), Expect = e-154, Method: Composition-based stats. Identities = 159/485 (32%), Positives = 266/485 (54%), Gaps = 15/485 (3%) Query: 59 LRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 + T ++ G+W+ +++ T P +G +G + + A+ AA +AF W ++ Sbjct: 1 MDTKLYIDGQWVNSSSGKTVDKYSPVTGQVIGRMEAATRDDVDRAIDAAEDAFWAWNDLG 60 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 + ERS ++ + L+ +N+ +L II E+GKP+KEA E+ +++++E AR++ G Sbjct: 61 SVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAKEEVDGVIDQIQYYAEWARKLNG 120 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 +++ + R+ K P G+ +TPWNFP+ M+ RK+ AL G TVV+KP+ DTP S Sbjct: 121 EVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNTVVLKPSSDTPGS 180 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A + +AG+P GV N I E+G+ I V+ I+ TGST TG+ ++ A Sbjct: 181 AEWIVRKFVEAGVPKGVLNFITG---RGSEIGDYIVEHKKVNLITMTGSTATGQRIMQKA 237 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 + ++ ++ +ELGG APF+V+ A++D A+ + +K+ N GQ+C+ + + V I+D F Sbjct: 238 SANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLYVHEDIYDTF 297 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 + F E + + L +G+ + GPLIN+ A++ + V +A GA ++ GG + L Sbjct: 298 MSRFVE-LSRKLALGDP--KNADMGPLINKGALQATSEIVEEAKESGAKILFGGSQPSLS 354 Query: 417 -----KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 FF PT++ N Q EE F P+ K + EE +AN GLA Y + Sbjct: 355 GPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDNKYGLASYLF 414 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK--Y 529 ++DP I+ +E++ G + VN + + G + +G EGSKYGI EYL+LK Y Sbjct: 415 TKDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGISEYLKLKNIY 474 Query: 530 VCYGG 534 V Y G Sbjct: 475 VDYSG 479 >6B4R-B nrPDB Length = 497 Score = 540 bits (1391), Expect = e-154, Method: Composition-based stats. Identities = 168/479 (35%), Positives = 262/479 (54%), Gaps = 14/479 (2%) Query: 59 LRTDSFVGGRWL--PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC--RWRE 114 + +FV G + + TF P G L VA C + +A AV+ A AF W Sbjct: 18 IEGRAFVNGEYSNAASGETFDCLSPVDGRFLAKVASCDLADAEQAVKVARNAFDSGAWSR 77 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARR 173 ++ +R + ++ +L+++N ++LA + T + GKP+ ++ H ++ +A L W +E + Sbjct: 78 LAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISDSLHIDVASAANSLRWSAEAIDK 137 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 +Y ++ TP + LV ++P+GV A I PWNFP M K+G ALA G +V++KP+E + Sbjct: 138 IYDEVAATPHAE-LGLVTREPVGVVAAIVPWNFPLLMSCWKLGPALATGNSVILKPSEKS 196 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P +A+ +A+LA +AGIP GV+NV+P VG+A+ V + FTGST K L+ Sbjct: 197 PLTAIRIAQLAVEAGIPKGVFNVLPGY---GHTVGKALALHMDVDTLVFTGSTKIAKQLM 253 Query: 294 HHAAN-SVKRVSMELGGLAPFIVFDSA-NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 +A ++KRV +E GG +P IVF A ++ A A + N G+ C ++ LV+R Sbjct: 254 VYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIAFNQGEVCTAGSRLLVERS 313 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 I D F+ EA+ K + GN + T G L++ + + V + + GA +V GGK Sbjct: 314 IKDKFLPLVIEAL-KGWKPGNPLDPETNVGALVDTQQMNTVLSYIEAGHNDGAKLVAGGK 372 Query: 412 R--HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 R + G + EPT+ VT M EE FGP+ VI+F+ EEA+ IAN GLA Sbjct: 373 RTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDAEEAVRIANDTPYGLAAA 432 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 ++ + ++ A+ L G V VN+ + PFGG KQSG GR+ S + D+Y ELK Sbjct: 433 VWTSNLSKAHLTAKALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELK 491 >5KLK-A nrPDB Length = 520 Score = 537 bits (1385), Expect = e-153, Method: Composition-based stats. Identities = 159/489 (32%), Positives = 266/489 (54%), Gaps = 13/489 (2%) Query: 54 LSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC-RW 112 + +A + +++ G ++ +A++F +P +G + V + ++ AV AA A W Sbjct: 33 IGSAPSQLLNYIDGNFVTSASSFANINPVNGKLISDVFEADAKQVNEAVVAAQNALKGPW 92 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEA 171 ++S ++R++L+ K + + ++ A++G+P+ +A +I + F++ A Sbjct: 93 GKLSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQARTLDIPRAIANFRTFADLA 152 Query: 172 RRVYGDIIH---TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 + + D+ + +++P+GV VI+PW+ P + T KV ALA G TVV K Sbjct: 153 KTSHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAK 212 Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTT 288 P+E++P SA LAE+ AG+P GV+N+I K++ GE + P +S ++FTG + T Sbjct: 213 PSEESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSA--GEFLTQHPGISALTFTGESKT 270 Query: 289 GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348 G ++ A+ VK VS ELGG +VF A++D A+ G + S F N+GQ C+CS + V Sbjct: 271 GSTIMKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYV 330 Query: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 R I D FV + + L VG ++G GPLI+ +KV AV +GATVVT Sbjct: 331 HRSIFDEFVSGL-KVEAERLVVGYPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVT 389 Query: 409 GGKRHQ-----LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 463 GG + + +PT+ ++ C EE FGP+ + FD E+E I N ++ Sbjct: 390 GGGVPKFNDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSN 449 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 523 GLA ++ + ++ RV+ Q+ VG+V VN + + PFGGVK SGLGREG ++ +D Sbjct: 450 YGLACAIWTTNLSRAHRVSRQIHVGLVWVNTWYLRDLRTPFGGVKLSGLGREGGRFSMDF 509 Query: 524 YLELKYVCY 532 Y ++ +C Sbjct: 510 YSDIANICI 518 >2HG2-A nrPDB Length = 479 Score = 536 bits (1381), Expect = e-152, Method: Composition-based stats. Identities = 169/475 (35%), Positives = 277/475 (58%), Gaps = 7/475 (1%) Query: 59 LRTDSFVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 ++ ++ G+++ A V +PA+ A + + D +AR A+ AA A W + Sbjct: 5 VQHPMYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQPEWEALP 64 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 A ER+S LRK + + +++ +I E GK + A E+ ++A ++++ +E ARR G Sbjct: 65 AIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWARRYEG 124 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 +II + L+ K+ +GV I PWNFP +I RK+ AL G T+V+KP+E TP + Sbjct: 125 EIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNN 184 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A+A A++ + G+P GV+N++ + VG+ + +P V+ +S TGS + G+ ++ A Sbjct: 185 AIAFAKIVDEIGLPRGVFNLVLG---RGETVGQELAGNPKVAMVSMTGSVSAGEKIMATA 241 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A ++ +V +ELGG AP IV D A+++ AV + S+ N+GQ C C+ + VQ+GI+D F Sbjct: 242 AKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQF 301 Query: 357 VKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 415 V EAM + ++ GN E GPLIN A+E+VE++V AV +GA V GGK + Sbjct: 302 VNRLGEAM-QAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEG 360 Query: 416 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 475 ++ PTLL +V Q+M HEETFGP+ PV+ FDT E+AI++AN +D GL Y+Q+ Sbjct: 361 KGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNL 420 Query: 476 AQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + + L+ G +N +++ G ++SG+G K+G+ EYL+ + V Sbjct: 421 NVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVV 475 >5IUV-A nrPDB Length = 497 Score = 533 bits (1374), Expect = e-152, Method: Composition-based stats. Identities = 169/480 (35%), Positives = 258/480 (53%), Gaps = 14/480 (2%) Query: 59 LRTDSFVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC--RWRE 114 + +F+ G + + TF P G L VA C +A+ AV +A AF W Sbjct: 18 IEGRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDSGAWSR 77 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARR 173 ++ +R + + ++ L+ QN ++LA + T + GKP+ ++ G +I A L W E + Sbjct: 78 LAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSGEAIDK 137 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 +Y ++ TP D+ LV ++P+GV A I PWNFP M K+G AL+ G +VV+KP+E + Sbjct: 138 LYDEVAATP-HDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKPSEKS 196 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P +A+ +A+LA +AGIP+GV NV+P VG+A+ V + FTGST K L+ Sbjct: 197 PLTAIRIAQLAIEAGIPAGVLNVLPGY---GHTVGKALALHMDVDTVVFTGSTKIAKQLM 253 Query: 294 HHAAN-SVKRVSMELGGLAPFIVFDSA-NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 +A ++KRV +E GG +P IVF A ++ A A ++ N G+ C ++ LV+R Sbjct: 254 IYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVERS 313 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 I D F+ EA+ + GN + T G L++ + + V + + GA +V GGK Sbjct: 314 IKDRFLPMVIEALG-TWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGK 372 Query: 412 RH--QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 + + G + EPT+ V M EE FGP+ V+ FDT EEAI IAN GLA Sbjct: 373 QILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAA 432 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 ++ + ++ A L G V VN+ + PFGG KQSG GR+ S + D+Y ELK Sbjct: 433 VWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKS 492 >1WNB-A nrPDB Length = 495 Score = 530 bits (1365), Expect = e-151, Method: Composition-based stats. Identities = 167/479 (34%), Positives = 255/479 (53%), Gaps = 8/479 (1%) Query: 56 AALLRTDSFVGGRWLPA-AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWRE 114 A L++ + G + PV +PA+G L +A+ + AAVRAA AF W + Sbjct: 19 AGLMQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQ 78 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARR 173 + K R+ L K +++ +N A + + GKPL A + EI +F+ AR Sbjct: 79 TTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARC 138 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + G + +++ + P+GV A I PWN+P M K+ ALAAG VV+KP+E T Sbjct: 139 LNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEIT 198 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P +AL LAELA P+GV N++ K VG+ + P V +S TGS TG+ ++ Sbjct: 199 PLTALKLAELAKDI-FPAGVVNILFG---RGKTVGDPLTGHPKVRMVSLTGSIATGEHII 254 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 H A+S+KR MELGG AP IVFD A+++ V G + N GQ C + + Q+GI+ Sbjct: 255 SHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIY 314 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG-ATVVTGGKR 412 D V+ A+ L+ G +E T GPL + +E+V K V +A + G V+TGG++ Sbjct: 315 DTLVEKLGAAVA-TLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEK 373 Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 + ++ PTLL QD +E FGP+ V FD EE+ + AN + GLA ++ Sbjct: 374 RKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWT 433 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 +D + RV+ +L+ G VN + E P GG K SG G++ S YG+++Y +++V Sbjct: 434 KDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVM 492 >3TY7-A nrPDB Length = 478 Score = 528 bits (1361), Expect = e-150, Method: Composition-based stats. Identities = 178/482 (36%), Positives = 258/482 (53%), Gaps = 14/482 (2%) Query: 55 SAALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRW 112 +A T ++ G W+ + + T V +PA+ +G VA + AV AA + + + Sbjct: 2 NAMRDYTKQYINGEWVESNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYLEF 61 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR 172 R S KER +LL K KDD+ + IT E G PL + E ++ L F Sbjct: 62 RHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAPL--SLSERVHYQMGLNHFVAARD 119 Query: 173 RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + D LV+K+ IGV+ +ITPWNFP+ + K+ AA AAG VV+KP+E+ Sbjct: 120 ALDNYEFEERRGDD--LVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEE 177 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 TPF+A+ LAE+ + G+P GV+N++ + VG + P V +SFTGS TG + Sbjct: 178 TPFAAVILAEIFDKVGVPKGVFNLVNG---DGAGVGNPLSEHPKVRMMSFTGSGPTGSKI 234 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + AA K+VS+ELGG +P+IV D ++ +A NTGQ C + LV I Sbjct: 235 MEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKI 294 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 DAF+ E + +RVGN E+GT GP+I++K ++V+ +N + +GA + GG Sbjct: 295 KDAFLAELKEQFSQ-VRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGGPG 353 Query: 413 HQLG---KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 G F PT+ NV M EE FGP+ VI ++ +EAI IAN GLAGY Sbjct: 354 KPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGY 413 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 +D + +VA +E G V +NE + PFGG KQSGLGRE YGI+E+LE+K Sbjct: 414 VIGKDKETLHKVARSIEAGTVEINEA-GRKPDLPFGGYKQSGLGREWGDYGIEEFLEVKS 472 Query: 530 VC 531 + Sbjct: 473 IA 474 >4O5H-A nrPDB Length = 511 Score = 528 bits (1360), Expect = e-150, Method: Composition-based stats. Identities = 167/480 (34%), Positives = 247/480 (51%), Gaps = 14/480 (2%) Query: 62 DSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WREVSA 117 +G W AA+ V +PA G + V + R+ + AV AA AF WR Sbjct: 32 QMLIGAEWSDAASGRQLDVVNPADGTVIARVPEADERDVQQAVAAARRAFDAGPWRTAKT 91 Query: 118 KERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYG 176 +R L+ +L+ N +LA I + ++GKP+ A G ++ +A + + A ++ G Sbjct: 92 TDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGWATKIEG 151 Query: 177 DIIHT-----PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 +I P + A K+P+GV I PWNFP M K+ ALA GCTVV+KPAE Sbjct: 152 SVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPAE 211 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 DTP SAL L EL AG P GV N++ G A+ DP + KI+FTGST TGK Sbjct: 212 DTPLSALRLGELIQAAGFPDGVVNIVTGY---GHTAGAALSRDPRIDKIAFTGSTQTGKT 268 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 + H A +++ R+S+ELGG +P IV ++D+A G + F N GQ C ++ + Sbjct: 269 IGHAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSK 328 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 + D ++ + +L++G G + T GPL++ K E+V ++ +GA GG+ Sbjct: 329 VFDGVIER-VAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGGR 387 Query: 412 RHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 F EPT+L + TQ M EE FGP+ + FD + A+ +AN GL + Sbjct: 388 AIDGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIW 447 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 S D + I ++ ++ G V VN + PFGG+KQSG GRE + ID+Y E K V Sbjct: 448 SNDLSAIHKLVPRIAAGTVWVNCHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSVM 507 >4U3W-A nrPDB Length = 505 Score = 523 bits (1347), Expect = e-148, Method: Composition-based stats. Identities = 174/482 (36%), Positives = 250/482 (51%), Gaps = 13/482 (2%) Query: 62 DSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR-WREVSAKER 120 ++ G ++ + TFP P G L V + +AV+AA+ A WR+ + +R Sbjct: 25 RHYINGEFVASGTTFPNLSPVDGRKLADVCEADAALVDSAVQAAHAAQKAGWRDTTPAQR 84 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVYGDII 179 ++ L K + + D+ A++G+P+ +A +I F++ R G+ Sbjct: 85 AAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTLDIARGIANFRTFADLVRTASGEYF 144 Query: 180 HT---PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 T + V ++P+GV +I+PWN P + T KV ALA G VV KP+E+TP S Sbjct: 145 ETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKPSEETPSS 204 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A LAE+ G+P GV+N+I +NA GE + P +S I+FTG + TG ++ Sbjct: 205 ATLLAEVMHDVGLPPGVFNLIHGHGQNA--AGEFLTRHPDISAITFTGESRTGSTIMKAV 262 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A+ VK VS ELGG +VF A+ D AVAG + S F N GQ C+CS + V+R I + F Sbjct: 263 ADGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVERPIFERF 322 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V A E + LRVG + TT GPLI+ +KV AV +GATVVTGG G Sbjct: 323 VAALKEQ-AQALRVGAPEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGGAPSFG 381 Query: 417 -----KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 F PT+ + C EE FGP+ + FD E E + N + GLA + Sbjct: 382 DARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGLAASIW 441 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + A+ RVA+Q+E G+V VN + + PFGG K SGLGREG ++ +D Y EL VC Sbjct: 442 TTQLARGHRVAKQIETGIVWVNAWFVRDLRTPFGGTKLSGLGREGGRHSLDFYSELTNVC 501 Query: 532 YG 533 Sbjct: 502 VR 503 >6C43-A nrPDB Length = 477 Score = 522 bits (1346), Expect = e-148, Method: Composition-based stats. Identities = 159/476 (33%), Positives = 248/476 (52%), Gaps = 8/476 (1%) Query: 59 LRTDSFVGGRWLPA-AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSA 117 ++ + G + V +PA+G + +A+ + AAV+AA AF W + + Sbjct: 4 MQYQLLINGVLVDGEGERQSVYNPATGEVILEIAEASPAQVDAAVQAADNAFAEWGQTTP 63 Query: 118 KERSSLLRKWYNLMIQNKDDLARIITAESGKPLK-EAHGEILYSAFFLEWFSEEARRVYG 176 K R+ L K + + QN + AR+ + GKPL + EI +F+ AR + G Sbjct: 64 KARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLSG 123 Query: 177 DIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 + +++ + PIGV A I PWN+P M K+ ALAAG VV+KP+E TP + Sbjct: 124 LAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLT 183 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 AL LA LA P GV NV+ + VG+ + V +S TGS TG+ +L H Sbjct: 184 ALKLAVLAKDI-FPPGVLNVLFG---RGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHT 239 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 A ++KR MELGG AP IVFD A++D G F N GQ C + + QRGI+DA Sbjct: 240 APAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDAL 299 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS-KGATVVTGGKRHQL 415 V+ A+ +L++G +E T GPL + +++V V +A + V+TGG + + Sbjct: 300 VEKLGNAVS-SLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEG 358 Query: 416 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 475 +F PTLL + Q+ E FGP+ + FD E++ + AN + GLA ++QD Sbjct: 359 KGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDV 418 Query: 476 AQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + R++ +L+ G +N + E P GG KQSG G++ S YG+++Y ++++ Sbjct: 419 GRAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIM 474 >3K2W-A nrPDB Length = 497 Score = 521 bits (1343), Expect = e-148, Method: Composition-based stats. Identities = 169/474 (35%), Positives = 272/474 (57%), Gaps = 10/474 (2%) Query: 63 SFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120 +F+GG+++P+ T + P++G +G + +A A+ A A W +++A+ R Sbjct: 15 NFIGGQYVPSNESDTIDILSPSTGKVIGEIPAGCKADAENALEVAQAAQKAWAKLTARTR 74 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180 ++LR + N + +NK LA ++ AE GK L A E+ +A F+++ + A + GDI+ Sbjct: 75 QNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEMEVDVTATFIDYGCDNALTIEGDILP 134 Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240 + +D + + K P GV IT WNFP A+ RK+G AL G T+V+KP ++TP + L Sbjct: 135 SDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQETPLATTEL 194 Query: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300 +A +AG+P GV NVI + VG+ +C P+ I+ TGST GK + +A + Sbjct: 195 GRIAKEAGLPDGVLNVINGT---GSVVGQTLCESPITKMITMTGSTVAGKQIYKTSAEYM 251 Query: 301 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAF 360 V +ELGG AP +V D A++D+A A+ +F N GQ C C + V ++D F+ F Sbjct: 252 TPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYDEFMAKF 311 Query: 361 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL----G 416 + K L+VG+ + + GP N++ ++ ++ V++A+ +GATV TGGK + G Sbjct: 312 LPLV-KGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATVEGFEG 370 Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476 ++EPT+L +V QD + HEETFGP+ P++K + E+AI N + GL+ Y ++Q A Sbjct: 371 GCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVHTQSFA 430 Query: 477 QIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 I + LEVG V +N G+ + G KQSG G E K+G+++YLE K V Sbjct: 431 NINQAISDLEVGEVYINRGMGEQHQGFHNGWKQSGFGGEDGKFGLEQYLEKKTV 484 >5EUY-A nrPDB Length = 491 Score = 521 bits (1342), Expect = e-148, Method: Composition-based stats. Identities = 153/482 (31%), Positives = 272/482 (56%), Gaps = 11/482 (2%) Query: 54 LSAALLRTDSFVGGRWL-PAAATFPV-QDPASGAALGMVADCGVREARAAVRAAYEAFCR 111 + +++ +++ G + P+ F V P G+ + V G +AR A+ +A+EA Sbjct: 2 IDLNIMKVANYINGEFKEPSTGAFQVKTSPVDGSKIAEVPRSGREDAREAIDSAFEALKA 61 Query: 112 WREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEA 171 W + A R+ L K + Q K+D +I+T E G ++ GE++++ ++ +E A Sbjct: 62 WANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVWGEVVFTERLIQNAAELA 121 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 R G ++ + ++ ++V K+ GV VITPWN+P ++ +K+ LA G TVV KPA Sbjct: 122 RHYQGRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVVYKPAS 181 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 DTP + +A++ ++AG+P GV+N++ VGE I T V+ ++FTG ++TG+ Sbjct: 182 DTPVTGWLIAQMVAKAGLPKGVFNLVIG---PGPVVGEEIVTHKRVAHVTFTGESSTGRE 238 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 + AA ++K V++ELGG P I+ D +VD A A+ + + GQ C + + +V + Sbjct: 239 IAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIVHKA 298 Query: 352 IHDAFVKAFAEAMKKNLRVGNGF-EEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 + D F++ + + K LR+ + +E GPLINE+ V +++ V+DAVS+G ++ GG Sbjct: 299 VADKFIERYVHYV-KMLRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLIGG 357 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 + NFFEP + +V ++ EE FGP+ P++ + +++A+ +AN D GL+G Sbjct: 358 RSW---GNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSGAV 414 Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529 + + + +R+AE +E GM +N+ + PFGG+K SG+GREG ++ E ++ Sbjct: 415 LTNNVNRAFRIAEAVESGMFHINDVTFLEESHVPFGGIKASGVGREGGEWSFHETTYDRW 474 Query: 530 VC 531 V Sbjct: 475 VT 476 >4F3X-A nrPDB Length = 498 Score = 515 bits (1326), Expect = e-146, Method: Composition-based stats. Identities = 144/479 (30%), Positives = 240/479 (50%), Gaps = 8/479 (1%) Query: 57 ALLRTDSFVGGRWLPAAATFP-VQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 +++ T +G R+ + +P +GA + +A+ + AAV AA AF W + Sbjct: 22 SMMDTQLLIGSRFEAGTEAEEHILNPRTGAGIIDLAEASHAQIDAAVDAAERAFVGWSQT 81 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRV 174 + ERS+ L K + + + D+ A + GKP+ E+ +F+ R + Sbjct: 82 TPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKNDELPAIIDCWRFFAGAVRNL 141 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 + +++ + PIG+ I PWN+P M+ K+ A+ G TVV KP+E TP Sbjct: 142 HAPAAGEYLPGHTSMIRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSEQTP 201 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 +AL LA L + +P GV NVI + VG A+ P V +S TG TGK +L Sbjct: 202 LTALKLARLIADI-LPEGVVNVITG---RGETVGNALINHPKVGMVSITGDIATGKKVLA 257 Query: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 AA +VKR +ELGG AP IV+ A+++ V G + N GQ C + + + GI++ Sbjct: 258 AAAKTVKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIYE 317 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK-GATVVTGGKRH 413 V A+ +R + GPLI+ + ++V V A + + TGG+ Sbjct: 318 KLVADLTSAVS-TIRYNLDDDTENEIGPLISRRQRDRVASFVERAADQKHIEITTGGRTG 376 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 FF+PT++ TQ+ E FGP+ V +F +++A+A AN +D GLA +++ Sbjct: 377 SDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVWTK 436 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 D ++ R A +L+ G +N + + E P GG+KQSG G++ S Y +++Y ++++ Sbjct: 437 DISKAMRAASRLQYGCTWINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIMI 495 >1T90-A nrPDB Length = 486 Score = 510 bits (1314), Expect = e-145, Method: Composition-based stats. Identities = 142/482 (29%), Positives = 233/482 (48%), Gaps = 11/482 (2%) Query: 56 AALLRTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 A + + +++ G W+ + V +PA+ L V + A + A EAF W Sbjct: 1 AEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKTWS 60 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 +V+ R+ +L + L+ Q+K++LA +IT E+GK KEA GE+ +E+ + Sbjct: 61 KVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSL 120 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + GD + + A D A + PIGV I P+NFP + A+A G T ++KP+E T Sbjct: 121 MMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERT 180 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P L EL +AG+P GV+NV+ A +V I P + ISF GS G+ + Sbjct: 181 PLLTEKLVELFEKAGLPKGVFNVVYG----AHDVVNGILEHPEIKAISFVGSKPVGEYVY 236 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353 + ++KRV G IV + AN++ V + + F + G+ C+ V+ GI Sbjct: 237 KKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIA 296 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG-KR 412 D F+ E + ++++GNG ++G GP+I E ++ + + +GA +V G + Sbjct: 297 DEFMAKLQEKVA-DIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGREN 355 Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 F PT+ NVT +M +E F P+ VI+ +EAI IAN ++ ++ Sbjct: 356 VSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFT 415 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLG--REGSKYGIDEYLELKY 529 + I E ++ GM+G+N G+ + + PF G K S G K +D Y K Sbjct: 416 SNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKV 475 Query: 530 VC 531 V Sbjct: 476 VT 477 >4JZ6-A nrPDB Length = 500 Score = 509 bits (1310), Expect = e-144, Method: Composition-based stats. Identities = 151/482 (31%), Positives = 240/482 (49%), Gaps = 8/482 (1%) Query: 58 LLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 ++T F+ W+ ++ TF + P S + A+ V +A A +AA EAF W++V Sbjct: 17 HMKTKLFINNAWIDSSDQQTFERKHPVSSEVMTESANATVTDAIKAAQAAEEAFKTWKDV 76 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVY 175 ER LL K ++M ++ E G A + SA + A ++ Sbjct: 77 GPSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWAGFNVHASANVFREAASLATQIQ 136 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G+ I T + ++ L+QP+G I PWN + + R + L G TVV K +E +P Sbjct: 137 GETIPTDKAETLSMTLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPA 196 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 + + + +AG+P+GV N + S + E+ +A+ + + +I+FTGST G I+ Sbjct: 197 THALITQCVQEAGLPAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQK 256 Query: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355 AA +KR +ELGG +P IV D A+++ AV A+ F GQ C+ + + +V I D Sbjct: 257 AAQHLKRCLLELGGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADE 316 Query: 356 FVKAFAEAMKKNLRVGNG-FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 FV F E ++ L VG+ GP+++ + E++ DA+ KGA VV GG Sbjct: 317 FVARFVEKTER-LSVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGGMAQ- 374 Query: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 T+L +V DM EETFGP+ VI+ E EAI IAN + GL+ + +D Sbjct: 375 --GAVMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRD 432 Query: 475 PAQIWRVAEQLEVGMVGVNEGLI-SSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 + RV +E G V +N + + + P+GG K +G GR + IDE+ ELK++ Sbjct: 433 INRALRVGMSIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELKWLTIE 492 Query: 534 GL 535 Sbjct: 493 PF 494 >5X5U-A nrPDB Length = 505 Score = 506 bits (1303), Expect = e-143, Method: Composition-based stats. Identities = 194/474 (40%), Positives = 276/474 (58%), Gaps = 6/474 (1%) Query: 60 RTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSA 117 T + G W+ AA+ T V +PA+G +G VA G+ + A+ AA F WR+V A Sbjct: 32 DTQLLIDGEWVDAASGKTIDVVNPATGKPIGRVAHAGIADLDRALAAAQSGFEAWRKVPA 91 Query: 118 KERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGD 177 ER++ +RK L+ + D +A+++T E GKPL EA E+L +A +EWF++E RRVYG Sbjct: 92 HERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARVEVLSAADIIEWFADEGRRVYGR 151 Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 I+ + V+K+P+G A TPWNFP + RK+ AALA GC+ +VK E+TP S Sbjct: 152 IVPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVKAPEETPASP 211 Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 AL AG+P+GV ++ + E+ + P++ K++FTGST GK L A Sbjct: 212 AALLRAFVDAGVPAGVIGLVYG---DPAEISSYLIPHPVIRKVTFTGSTPVGKQLASLAG 268 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 +KR +MELGG AP IV + A+V AV A +KFRN GQ C+ +FLV I D F Sbjct: 269 LHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHNSIRDEFT 328 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 +A + + L+VGNG EEGTT G L N + + + +++A GA++ TGG+R Sbjct: 329 RALVK-HAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGASIETGGERIGSEG 387 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 NFF PT++ NV D + E FGP+A + FD EEAIA AN GLAGY +++ A Sbjct: 388 NFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGYAFTRSFAN 447 Query: 478 IWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + + ++LEVGM+ +N+ E PFGGVK SG G EG ++ YL K V Sbjct: 448 VHLLTQRLEVGMLWINQPATPWPEMPFGGVKDSGYGSEGGPEALEPYLVTKSVT 501 >3I44-A nrPDB Length = 497 Score = 506 bits (1303), Expect = e-143, Method: Composition-based stats. Identities = 161/497 (32%), Positives = 262/497 (52%), Gaps = 20/497 (4%) Query: 42 AQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREAR 99 AQ + L + ++ G W + V DP++ A +++ R+A Sbjct: 14 AQTQGPGSML-------NKRKFYINGLWDDPSTPHDLYVIDPSTEEACAVISLGSTRDAD 66 Query: 100 AAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEIL 158 A+ AA +AF W+ S ER + K + + D+A+ I+ E G P+ A + Sbjct: 67 KAINAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTA 126 Query: 159 YSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAA 218 + + F + + + +A++ IGV +ITPWN+P +T KV A Sbjct: 127 TGSSHIRNFIKAYKEFSFQEALIEGNE-QAILHYDAIGVVGLITPWNWPMNQVTLKVIPA 185 Query: 219 LAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVS 278 L AGCT+V+KP+E P SA+ AE+ +A +PSGV+N+I + VG + P + Sbjct: 186 LLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLING---DGANVGSYLSAHPDLE 242 Query: 279 KISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQ 338 ISFTGST GK + +A+N++KRV +ELGG I+F A++D A+ + F N+GQ Sbjct: 243 MISFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYNSGQ 301 Query: 339 TCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVND 398 +C + LV++ I+D + A+ + + +VG G + G GP+++++ +K++ + Sbjct: 302 SCNAPTRMLVEQAIYDKAI-KTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQS 360 Query: 399 AVSKGATVVTGGKRHQLG---KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEA 455 + +GAT+VTGG +G + PT+ +V M EE FGP+ ++ F+TE+EA Sbjct: 361 GIDEGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEA 420 Query: 456 IAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGRE 515 + +AN + GL Y SQD ++ R+A Q+ GMV VN + FGGVK SG RE Sbjct: 421 VTLANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVEVNGHELPG-GSYFGGVKFSGRARE 479 Query: 516 GSKYGIDEYLELKYVCY 532 G +GI E+L+ K + Y Sbjct: 480 GGLWGIKEFLDTKAISY 496 >3RHD-A nrPDB Length = 486 Score = 505 bits (1301), Expect = e-143, Method: Composition-based stats. Identities = 151/476 (31%), Positives = 248/476 (52%), Gaps = 19/476 (3%) Query: 63 SFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSS 122 F+ G+W+ V +P S + + EA+ A+ A + + + +R + Sbjct: 2 MFIDGKWIN-REDMDVINPYSLEVIKKIPALSREEAKEAIDTAEKYKEVMKNLPITKRYN 60 Query: 123 LLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTP 182 +L + + K++LA+I+ ++GKP+K+A E+ S + + + ++I + Sbjct: 61 ILMNIAKQIKEKKEELAKILAIDAGKPIKQARVEVERSIGTFKLAAFYVKEHRDEVIPSD 120 Query: 183 AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAE 242 DR ++P+G+ ITP+NFP + K+ A+A G +V P+ P + LA+ Sbjct: 121 --DRLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIELAK 178 Query: 243 LASQA----GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298 + A +P GVYN++ + + VG+ I + V+ ISFTGS+ G+++ A Sbjct: 179 IIENALKKYNVPLGVYNLLTGA---GEVVGDEIVVNEKVNMISFTGSSKVGELITKKAG- 234 Query: 299 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVK 358 K++++ELGG+ P IV A++++AV + F GQ C+ LV I D F++ Sbjct: 235 -FKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFIE 293 Query: 359 AFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN 418 F K L VGN +E T GPLI+ + E VEK V A+ +G ++ GGKR K Sbjct: 294 MFVNK-AKVLNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGKRD---KA 349 Query: 419 FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI 478 F PT+L V +D + ETF P+ P+I+ EEE I IAN+ + GL ++ D + Sbjct: 350 LFYPTILE-VDRDNILCKTETFAPVIPIIR-TNEEEMIDIANSTEYGLHSAIFTNDINKS 407 Query: 479 WRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 + AE LE G V +N+ + + PFGGVK+SGLGREG KY ++E +K + Sbjct: 408 LKFAENLEFGGVVINDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIIIS 463 >2JG7-A nrPDB Length = 510 Score = 505 bits (1300), Expect = e-143, Method: Composition-based stats. Identities = 126/485 (25%), Positives = 225/485 (46%), Gaps = 5/485 (1%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC 110 L L + + G W + PA+ + V + E V+ EA+ Sbjct: 13 LKELGLSEDNPGVY-NGSWGGSGEVITSYCPANNEPIARVTQATLAEYEETVQKTREAWK 71 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEE 170 W ++ A +R ++R+ + + + L +++ E GK E GE+ ++ Sbjct: 72 MWADIPAPKRGEIVRQIGDALRKKIKVLGSLVSLEMGKIYVEGVGEVQEYVDVCDYAVGL 131 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 +R + G ++ + + P+G+ +IT +NFP A+ AL G + K A Sbjct: 132 SRMIGGPVLPSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGA 191 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 TP +++A+ ++ ++ + + I ++G A+ D V +SFTGST GK Sbjct: 192 PTTPLTSVAVTKIVAEVLEQNNLPGAICSMTCGGADIGTAMAKDERVDLLSFTGSTHVGK 251 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 ++ R +ELGG IVF+ A+++ V A+ + GQ C + + ++ Sbjct: 252 MVAMMVQERFGRKLLELGGNNAIIVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHE 311 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 +HDA V+ A+A K+ +R+G+ ++ T GPL ++AV++ + A +G T+V GG Sbjct: 312 SVHDAVVERIAKAYKQ-VRIGDPWDPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGG 370 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 K N+ EPT++ + D H ETF P+ V+KF TEEEA A N GL+ Sbjct: 371 KVMDRPGNYVEPTIITGLAHDAPIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSI 430 Query: 471 YSQDPAQIWR--VAEQLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGIDEYLEL 527 +++D +++R + + G+V VN + + FGG K +G GRE +Y+ Sbjct: 431 FTKDLGRVFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRR 490 Query: 528 KYVCY 532 Sbjct: 491 STCTI 495 >3QAN-A nrPDB Length = 538 Score = 500 bits (1288), Expect = e-142, Method: Composition-based stats. Identities = 143/480 (29%), Positives = 231/480 (48%), Gaps = 21/480 (4%) Query: 65 VGGRWLPAAATFPVQDPA-SGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 + G + +PA +G V+ A A+++A EAF WR V+ +ER+++ Sbjct: 42 INGERVTTEDKIQSWNPARKDQLVGSVSKANQDLAEKAIQSADEAFQTWRNVNPEERANI 101 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPA 183 L K ++ + K + + + E+GKP KEA + + FLE+++ + + Sbjct: 102 LVKAAAIIRRRKHEFSAWLVHEAGKPWKEADADTAEAIDFLEYYARQMIELNRGKEILSR 161 Query: 184 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL 243 + P+GV I+PWNF A++ A + G TVV+KPA TP A E+ Sbjct: 162 PGEQNRYFYTPMGVTVTISPWNFALAIMVGTAVAPIVTGNTVVLKPASTTPVVAAKFVEV 221 Query: 244 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA------ 297 AG+P GV N +P S EVG+ + P S I+FTGS G L AA Sbjct: 222 LEDAGLPKGVINYVPGS---GAEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAVVRPGQ 278 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 N +KRV +E+GG +V A++D A + S F +GQ C ++ ++ + ++D + Sbjct: 279 NHLKRVIVEMGGKDTVVVDRDADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDVYDEVL 338 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 + A+ KNL VG+ GP+I+EKA EK+ + +G ++TGG+ Sbjct: 339 EKTV-ALAKNLTVGDPTNRDNYMGPVIDEKAFEKIMSYIEIGKKEG-RLMTGGEGDSSTG 396 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F +PT++ ++ + + EE FGP+ K + + A+ IAN + GL G +++ A Sbjct: 397 FFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFDHALEIANNTEYGLTGAVITRNRAH 456 Query: 478 IWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEYLEL----KYVC 531 I + + VG + N ++ PFGG K SG SK G +YL L K V Sbjct: 457 IEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSGT---DSKAGGPDYLALHMQAKTVS 513 >3U4J-A nrPDB Length = 528 Score = 500 bits (1287), Expect = e-142, Method: Composition-based stats. Identities = 173/477 (36%), Positives = 262/477 (54%), Gaps = 10/477 (2%) Query: 60 RTDSFVGGRWLP--AAATFPVQDPAS-GAALGMVADCGVREARAAVRAAYEAFCR--WRE 114 R V G+ + + +T P G +G + + R AV AA +AF W Sbjct: 22 RYQMLVDGKSVDAASGSTIDRVSPGHAGEVVGTWPEASADDVRKAVAAARKAFDAGPWPR 81 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRV 174 +S ERS L+ K +L++ +++LA I + E GKP+ +A GEI + A + + +AR + Sbjct: 82 MSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQARGEIGFCADLWSYAAGQARAL 141 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 G + DR LVL++P+GV +ITPWNFP + + +V A+ +GCTVV+KP+E T Sbjct: 142 EGQTHNNIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEFTS 201 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 +++ LAELA +AGIP GV+NV+ A G+ + DP V ++FTGS G L Sbjct: 202 GTSIRLAELAREAGIPDGVFNVVTGYGDPA---GQVLAEDPNVDMVAFTGSVRVGTKLGE 258 Query: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 AA +VKRV +ELGG P IVF A++D A G + N GQ C+ ++ LVQ GI D Sbjct: 259 IAARTVKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQEGIRD 318 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 A ++ + + + + G+ E T G +I+E EKV V ++ GA ++ GG+R Sbjct: 319 ALMERLLD-ISRKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGERIG 377 Query: 415 LG-KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 ++ PT+ VT DM EE FGP+ + F T +EA+A+ANA + GL+ +S Sbjct: 378 REAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSASVWST 437 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + + ++ G +N + + E P GG K+SGLGRE +YG DEY + K V Sbjct: 438 NLETALQTIRRIRAGRCWINSVIDGTPELPIGGYKKSGLGRELGRYGFDEYSQFKGV 494 >5VBF-A nrPDB Length = 478 Score = 498 bits (1282), Expect = e-141, Method: Composition-based stats. Identities = 190/472 (40%), Positives = 272/472 (57%), Gaps = 6/472 (1%) Query: 62 DSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKE 119 ++ GR+ A T PV DP + LG + + AAV+AA+ AF WR S Sbjct: 8 RLYIDGRFHDADGRRTQPVVDPGTTRVLGELPHATAHDIDAAVQAAHRAFVTWRHESPLV 67 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII 179 RS LLR+ L + + + R IT + GKPL+EA E++ +A LEW +EE RR YG ++ Sbjct: 68 RSDLLRRAAALARERAETIGRHITMDQGKPLREAIAEVVSAAEQLEWHAEEGRRTYGRVV 127 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 + D VL++PIGV A +PWNFP + K+ AALA+GCT+V+K E++P + +A Sbjct: 128 PARSPDVMQTVLREPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPSAIVA 187 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 LA+L AG+P G N++ +V + + P V KISFTGS GK L AA+ Sbjct: 188 LAQLFHDAGLPPGCLNIVWGVPG---DVSKQLIEAPQVRKISFTGSVPVGKQLAALAASL 244 Query: 300 VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKA 359 +KR++MELGG AP +V A+V++A A A KFRN GQ CV +F VQR D FV A Sbjct: 245 MKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFVCA 304 Query: 360 FAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNF 419 + +A+ +RVG G + G T GPL + + V++++ V DA +KGA + TGG R ++ Sbjct: 305 YLDAVG-TIRVGYGLDAGVTMGPLAHARRVDEIDAFVADATAKGAQIATGGMRLPGPGHY 363 Query: 420 FEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIW 479 F PT++ T+D ++E FGP+ ++ FD ++A+A AN GLA Y ++ Sbjct: 364 FAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSARNAH 423 Query: 480 RVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 R++ LE GMV +N + E PFGGVK SG G EG D YL K+V Sbjct: 424 RISRALEAGMVNINHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGYLVTKFVT 475 >4X0T-A nrPDB Length = 513 Score = 496 bits (1278), Expect = e-141, Method: Composition-based stats. Identities = 124/470 (26%), Positives = 208/470 (44%), Gaps = 4/470 (0%) Query: 66 GGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLR 125 G W PA+ + V V + V+ A EA+ W ++ A +R ++R Sbjct: 30 NGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVR 89 Query: 126 KWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKD 185 + + + + L +++ E GK L E GE+ ++ +R + G I+ + Sbjct: 90 QIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSG 149 Query: 186 RRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELAS 245 + P+G+ +IT +NFP A+ A+ G + K A T ++A+ ++ + Sbjct: 150 HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIA 209 Query: 246 QAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSM 305 + + + I ++G A+ D V+ +SFTGST GK + R + Sbjct: 210 KVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLL 269 Query: 306 ELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMK 365 ELGG I F+ A++ V A+ + GQ C + + + IHD V +A Sbjct: 270 ELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYA 329 Query: 366 KNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLL 425 + +RVGN ++ GPL ++AV V +A +G TVV GGK N+ EPT++ Sbjct: 330 Q-IRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIV 388 Query: 426 CNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWR--VAE 483 + D H ETF P+ V KF EEE A N GL+ +++D +I+R + Sbjct: 389 TGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPK 448 Query: 484 QLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 + G+V VN + + FGG K +G GRE +Y+ Sbjct: 449 GSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 498 >3RJL-A nrPDB Length = 538 Score = 495 bits (1274), Expect = e-140, Method: Composition-based stats. Identities = 129/472 (27%), Positives = 217/472 (45%), Gaps = 17/472 (3%) Query: 65 VGGRWLPAAATFPVQDPAS-GAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 + G +PA+ +G V+ A A++AA +AF WR +ER+++ Sbjct: 42 IDGERYETENKIVSINPANKEEVVGTVSKATQDHAEKAIQAAAKAFETWRYTDPEERAAV 101 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPA 183 L + + + K + + ++ E+GKP EA + + F+E+++ + + Sbjct: 102 LFRAVAKVRRKKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR 161 Query: 184 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL 243 + R + P GV VI PWNF A++ A + G TVV+KPA P A E+ Sbjct: 162 EGERNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASAAPVIAAKFVEV 221 Query: 244 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN----- 298 ++G+P GV N +P S EVG+ + P S I+FTGS G + AA Sbjct: 222 LEESGLPKGVVNFVPGS---GAEVGDYLVDHPKTSIITFTGSREVGTRIFERAAKVQPGQ 278 Query: 299 -SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 +K+V E+GG +V + +++ A S F GQ C ++ +V ++D + Sbjct: 279 THLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYDEVL 338 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 K E + ++ +VG GP+I++ + K+ + +G +V+GGK Sbjct: 339 KRVIE-ITESKKVGEPDSADVYMGPVIDQASFNKIMDYIEIGKEEG-RLVSGGKGDDSKG 396 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F EPT+ ++ EE FGP+ K + +EA+ +AN + GL G +++ Sbjct: 397 YFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFDEALEVANNTEYGLTGAVITKNRDH 456 Query: 478 IWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEYLEL 527 I R ++ VG + N ++ PFGG K SG SK G +YL L Sbjct: 457 INRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGT---DSKAGGPDYLAL 505 >3RH9-A nrPDB Length = 506 Score = 494 bits (1273), Expect = e-140, Method: Composition-based stats. Identities = 189/482 (39%), Positives = 278/482 (57%), Gaps = 7/482 (1%) Query: 55 SAALLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRW 112 S L ++GGRW +A ATF V +PA+G+ + V + AAV A A Sbjct: 6 SPLLENLTGYIGGRWKDSAGGATFDVYNPATGSVIAKVPSMPEEDVVAAVEAGQSALRLT 65 Query: 113 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEAR 172 + R L + + +N++++ RI+ E GKP KEA GE+ Y+A F ++ ++ Sbjct: 66 NPWPIETRRKWLEDIRDGLKENREEIGRILCMEHGKPWKEAQGEVDYAAGFFDYCAKHIS 125 Query: 173 RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + I KD V +P+GV +I PWNFP MI +K+ AALAAGC V+KPA + Sbjct: 126 ALDSHTIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPASE 185 Query: 233 TPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL 292 TP + +A + + +P G+ N++ A +G+ +C V +SFTGST G+ L Sbjct: 186 TPLTMIAFFSVMDKLDLPDGMVNLVMG---KASVIGKVLCEHKDVPMLSFTGSTEVGRKL 242 Query: 293 LHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 + A VK++++ELGG APFIVFD A+++ A +A+KFR GQTCVC+N+ V + Sbjct: 243 IVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKV 302 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 DAF + AE + K + VG+G +G GPLIN++ +KV++ + DA+ KGA++V G + Sbjct: 303 ADAFGQKLAERVNK-MTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAGKQP 361 Query: 413 HQLGKN-FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 +LG FF PT++ V ++M C EETFGPL P+ F TEEE I N + GLA Y + Sbjct: 362 AELGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVF 421 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531 + D + RVA L G VG N G + E PFGG+K SG+GREG G+ E++E + V Sbjct: 422 TADAERAQRVAAGLRFGHVGWNTGTGPTPEAPFGGMKASGIGREGGLEGLFEFVEAQTVP 481 Query: 532 YG 533 G Sbjct: 482 RG 483 >4PXN-A nrPDB Length = 525 Score = 490 bits (1262), Expect = e-139, Method: Composition-based stats. Identities = 132/485 (27%), Positives = 220/485 (45%), Gaps = 5/485 (1%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC 110 LA L A +F G W + T P + + V + V + +RA ++A Sbjct: 28 LAELGLAQRNPGAFACGAWGGSGPTVTSTSPTNNQVIAEVVEASVHDYEEGMRACFDAAK 87 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEE 170 W + A +R ++R+ + + L R+++ E GK L E GE+ ++ Sbjct: 88 TWMAIPAPKRGEIVRQIGDALRAKLHHLGRLVSLEMGKILPEGIGEVQEIIDMCDYAVGL 147 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 +R++ G II + + + + P+GV VIT +NFP A++ AL G VV K A Sbjct: 148 SRQLNGSIIPSERPNHMMMEVWNPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGA 207 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 TP +A+ ++ + + + I S E+G+AI D + +SFTGST G Sbjct: 208 PTTPLITIAMTKIVASVLEKNNLPGAIFTSFCGGTEIGQAIALDIRIPLVSFTGSTRAGL 267 Query: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350 ++ + + +EL G IV D A++ AV + + GQ C + ++ Sbjct: 268 MVQQQVSARFGKCLLELSGNNAIIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHE 327 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 I+ F+ E K+ +R+G+ E+GT GPL + E K + S+G ++ GG Sbjct: 328 NIYQTFLDQLVEVYKQ-VRIGDPLEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGG 386 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 + NF +PT++ +T EE FGP+ V+KF T +EAI I N+ GL+ Sbjct: 387 SAIESEGNFVQPTIVE-ITPSAPVVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSI 445 Query: 471 YSQDPAQI--WRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 +++ P I W + G+V VN + + FGG K +G GRE +Y+ Sbjct: 446 FTKRPDIIFKWLGPHGSDCGIVNVNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRR 505 Query: 528 KYVCY 532 Sbjct: 506 ATCTI 510 >2QE0-A nrPDB Length = 475 Score = 487 bits (1253), Expect = e-138, Method: Composition-based stats. Identities = 154/477 (32%), Positives = 248/477 (51%), Gaps = 16/477 (3%) Query: 62 DSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERS 121 ++V G W + + +PASGA LG V E +A +A WR +S ER+ Sbjct: 6 KNYVNGEWKLSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKKAQPAWRALSYIERA 65 Query: 122 SLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII-- 179 + L K ++++++K+ + I++ E K K A E++ +A + + +EE R+ G+++ Sbjct: 66 AYLHKVADILMRDKEKIGAILSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEGEVLEG 125 Query: 180 ---HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 +K + A+V ++P+G+ I+P+N+P + K+ AL AG + KP S Sbjct: 126 GSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSIS 185 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 L LAE ++AG+P+GV+N I E+G+ I V+ I+FTGST G+ + A Sbjct: 186 GLLLAEAFAEAGLPAGVFNTITG---RGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMA 242 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 ++ + + LGG IV + A+++ +A F +GQ C + LV + D Sbjct: 243 G--MRPIMLALGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADEL 300 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V+ E + L +GN E+ PLI+ K+ + VE +NDA KGAT +T KR Sbjct: 301 VEKIREKVLA-LTIGNP-EDDADITPLIDTKSADYVEGLINDANDKGATALTEIKR---E 355 Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476 N P L VT DM EE FGP+ P+I+ + EEAI I+N ++ GL ++ D Sbjct: 356 GNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFP 415 Query: 477 QIWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 + + +AEQLEVG V +N + PF G K+SG G +G KY I+ +K V + Sbjct: 416 RAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVVF 472 >4LIH-A nrPDB Length = 504 Score = 484 bits (1247), Expect = e-137, Method: Composition-based stats. Identities = 170/485 (35%), Positives = 264/485 (54%), Gaps = 18/485 (3%) Query: 59 LRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR--WRE 114 + +F+ G A TF P G L VADCG + AAV AA AF W Sbjct: 26 IEGRAFIDGASRDAHGGRTFDCVSPIDGRVLAKVADCGEADVNAAVAAARRAFDAGVWAG 85 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARR 173 ++ + R ++L +W LM ++ D+L+ + T ++GKP+ + ++ +A+ +EWF+E + Sbjct: 86 LNPRARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAEAIDK 145 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 V G++ LV ++P+GV A + PWNFP M K G ALAAG +VV+KP+E + Sbjct: 146 VGGEVAPAD-HHLVGLVTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVVLKPSEKS 204 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P +A+ +A+LA +AGIP+GV+NV+P A E G+ + V I+FTGST GK+++ Sbjct: 205 PLTAIRVAQLAFEAGIPAGVFNVVPG----AGEPGKLLALHRDVDCIAFTGSTAVGKLIM 260 Query: 294 HHAAN-SVKRVSMELGGLAPFIVFDSA-NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 +AA ++KR +ELGG +P IV ++D+A A + F N G+ C ++ LV R Sbjct: 261 QYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLVHRD 320 Query: 352 IHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK 411 I DAF++ A + + GN + + G +++ +E+V + +G +VTGG Sbjct: 321 IKDAFIEKLVAAARAYVP-GNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEG-RLVTGGA 378 Query: 412 R--HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469 R + G + EPT+ V D EE FGP+ VI FD +EA+ IAN + GLA Sbjct: 379 RVNAETGGFYVEPTVFE-VKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAAA 437 Query: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528 ++ + V+ +L G V VN + PFGG KQSG GR+ S + +++Y ELK Sbjct: 438 VWTSNLTTAHDVSRRLRAGTVWVNCYDEGGDMNFPFGGYKQSGNGRDKSLHALEKYTELK 497 Query: 529 YVCYG 533 Sbjct: 498 STLIR 502 >4DNG-A nrPDB Length = 485 Score = 483 bits (1243), Expect = e-136, Method: Composition-based stats. Identities = 138/477 (28%), Positives = 248/477 (51%), Gaps = 12/477 (2%) Query: 61 TDSFVGGRWL--PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAK 118 SF+ G+W + T + +P + + + ++ A A +A W + + + Sbjct: 7 NKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQKEWAKSTTE 66 Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG-D 177 +R ++L+K + +N+DD+ +I E+G + ++ E+ + L+ + G Sbjct: 67 DRKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTIELEQTIAILDEAMTYTGELGGVK 126 Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237 + + + + + + P+GV + I+P+NFP + R + A+A G +VV KP T S Sbjct: 127 EVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQTAISG 186 Query: 238 -LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 +A+ AG+P+GV NV+ + KE+G+ + T+P+ ISFTGST G+ + A Sbjct: 187 GTIIAKAFEHAGLPAGVLNVMLT---DVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIA 243 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 + KR+++ELGG PF V A+VD+AV A+ KF + GQ C+ N+ +V + ++D F Sbjct: 244 GRAFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYDEF 303 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V+ F +K+ L G+ + T GPLINE+ +EK + + A + G + GKR Sbjct: 304 VEKFTARVKQ-LPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGKRV--- 359 Query: 417 KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPA 476 N P + + E F P+A +IK +++EAI +AN + GL+ ++ D Sbjct: 360 GNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTSDLE 419 Query: 477 QIWRVAEQLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 + + A Q++ GM VN+ ++ FGG K SG+GR G+ + ++E+ K++ Sbjct: 420 KGEKFALQIDSGMTHVNDQSVNDSPNIAFGGNKASGVGRFGNPWVVEEFTVTKWISI 476 >6FK3-A nrPDB Length = 536 Score = 477 bits (1227), Expect = e-135, Method: Composition-based stats. Identities = 147/491 (29%), Positives = 226/491 (46%), Gaps = 19/491 (3%) Query: 52 AGLSAALLRTDSFVGGRWLPAAATFPVQDPAS-GAALGMVADCGVREARAAVRAAYEAFC 110 AG L VGG + ++P+ + + R A A EAF Sbjct: 11 AGKYGNTLEFGHLVGGEEVLEGPLLERRNPSDREDVVARFPEADKDLVRKAALKAREAFA 70 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEE 170 W A R +L ++ + K L R++ E GK KEA G++ + +F+ E Sbjct: 71 EWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEAAGDVQEAIDTALFFASE 130 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 RR+YG + + +D+ ++P+GV +IT NFP A+ + K+ A+ G TVV KP+ Sbjct: 131 GRRLYGQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPSWKLIPAVLTGNTVVWKPS 190 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKN-AKEVGEAICTDPLVSKISFTGSTTTG 289 ED P + A+L +AG+P GV NV+ K + + + L K +FTGST G Sbjct: 191 EDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELMDEGLFQKFAFTGSTQVG 250 Query: 290 KILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 + + A ++ R ++ELGG P +V A++D AV GA S F GQ C + LV Sbjct: 251 RWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSAFATGGQRCTSAGNILVD 310 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNG-FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408 I++ F + F E ++ L VGN T GP INE+ + ++ ++GA ++ Sbjct: 311 APIYEEFKRRFLERVEATL-VGNPLLHPEVTYGPFINERFFARWQEHYRVGEAEGARLLF 369 Query: 409 GGKRHQLGKNFFE------------PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAI 456 G R + PT+ V EE FGP ++K D EEAI Sbjct: 370 GRGRITRENPYPRFLGDPEAGLYGWPTVWE-VRPGTRLFTEEVFGPTINLVKVDGIEEAI 428 Query: 457 AIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISS-VECPFGGVKQSGL-GR 514 A+AN+ GL+ Y+ + + GM +N + + PFGGVK SG GR Sbjct: 429 AVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGAEAHLPFGGVKASGNGGR 488 Query: 515 EGSKYGIDEYL 525 E + ++EY Sbjct: 489 ESGIWVLEEYT 499 >4ZZ7-A nrPDB Length = 501 Score = 474 bits (1220), Expect = e-134, Method: Composition-based stats. Identities = 134/488 (27%), Positives = 228/488 (46%), Gaps = 14/488 (2%) Query: 55 SAALLRTDSFVGGRWL-PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 + + + G+ + + V +PA+G + + A+ AA AF WR Sbjct: 1 GSHMTTIGHLINGQLVTENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWR 60 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 +R+ ++ ++ L+ Q+ D++ R+I E GK +A GE+ +E+ Sbjct: 61 NTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPEL 120 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 + G+ + QP+GV A ITP+NFP + A+ G V+KP+E Sbjct: 121 LKGEHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERD 180 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P S L +A+L +AG+P GV NV+ KE +A+ D V +SF GST + + Sbjct: 181 PSSTLYIAQLLQEAGLPDGVMNVVNG----DKEAVDALLHDDRVKAVSFVGSTPIAEYIY 236 Query: 294 HHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL-VQRGI 352 A+ + KR G IV A++D AV + + F ++G+ C+ + + V Sbjct: 237 RTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAA 296 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 DA V +AM+K L+VG + G GP+I + EKV +N A +GAT+V G++ Sbjct: 297 GDALVSKMTQAMQK-LKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQ 355 Query: 413 HQLG----KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468 ++ F TL+ +VT +M EE FGP+ V++ T ++A+ + +A + G Sbjct: 356 PKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGT 415 Query: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEG-LISSVECPFGGVKQSGLG--REGSKYGIDEYL 525 +++D ++ ++VGMVG+N + FGG K+S G + Y Sbjct: 416 CIFTRDGEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYT 475 Query: 526 ELKYVCYG 533 + K V Sbjct: 476 KRKTVTQR 483 >3B4W-A nrPDB Length = 495 Score = 473 bits (1218), Expect = e-134, Method: Composition-based stats. Identities = 153/483 (31%), Positives = 249/483 (51%), Gaps = 14/483 (2%) Query: 55 SAALLRTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAFC-- 110 +A F+GG+W + + V+ PA+G +G V + AAV AA AF Sbjct: 3 DSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNG 62 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSE 169 W ER++++ ++ + KD +++ AE+G+P + S + +F+ Sbjct: 63 PWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAG 122 Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229 A +V T +++V ++P+GV I WN P + K+ AL AGCT+V+KP Sbjct: 123 AADKVTWTETRT-GSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKP 181 Query: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289 A +TP +A ALAE+ ++ G+P GV +V+P E G+A+ ++P + +FTGS+ G Sbjct: 182 AAETPLTANALAEVFAEVGLPEGVLSVVPG----GIETGQALTSNPDIDMFTFTGSSAVG 237 Query: 290 KILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349 + + AA +K ++ELGG + I+ + ++ A+ + S N GQ CV + L Sbjct: 238 REVGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAP 297 Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 R +D V A + L VG + GPLI+EK +VE + + +GA +V G Sbjct: 298 RSRYDEIVAAVTNFVTA-LPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCG 356 Query: 410 GKRHQ--LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467 G R + F +PT+ +V M EE FGP+ +I +DTEE+AIAIAN + GLA Sbjct: 357 GGRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLA 416 Query: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527 G ++ D + ++++Q+ G G+N PFGG K SG+GRE G++ + + Sbjct: 417 GSVWTTDVPKGIKISQQIRTGTYGINWY-AFDPGSPFGGYKNSGIGRENGPEGVEHFTQQ 475 Query: 528 KYV 530 K V Sbjct: 476 KSV 478 >3R64-A nrPDB Length = 508 Score = 471 bits (1213), Expect = e-133, Method: Composition-based stats. Identities = 154/486 (31%), Positives = 251/486 (51%), Gaps = 17/486 (3%) Query: 51 LAGLSAALLRTDSFVGGRWLPAAATF--PVQDPASGAALGMVADCGVREARAAVRAAYEA 108 AG+ A T +GG+W+ + +P + + + + AA AA +A Sbjct: 7 FAGIDA----TKHLIGGQWVEGNSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKA 62 Query: 109 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFS 168 W A ERS+++ + L+ ++++++ + ESG +A+ EI + + + Sbjct: 63 QAEWAATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLEITLAGNITKESA 122 Query: 169 EEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVK 228 RV+G I + + V + GV VI+PWNFP + R V ALA G VV+K Sbjct: 123 SFPGRVHGRISPSNTPGKENRVYRVAKGVVGVISPWNFPLNLSIRSVAPALAVGNAVVIK 182 Query: 229 PAEDTPFSALAL-AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287 PA DTP + + A + +AG+P+GV + + + E+G+ T + ISFTGST Sbjct: 183 PASDTPVTGGVIPARIFEEAGVPAGVISTVAGA---GSEIGDHFVTHAVPKLISFTGSTP 239 Query: 288 TGKILLHHA--ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQ 345 G+ + A +K V++ELGG APF+V A++D A A F + GQ C+ N+ Sbjct: 240 VGRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAVGAFLHQGQICMSINR 299 Query: 346 FLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGAT 405 +V +HD F++ F EA+ KN+ G+ EGT GP+IN+ + +++++ A +GAT Sbjct: 300 VIVDAAVHDEFLEKFVEAV-KNIPTGDPSAEGTLVGPVINDSQLSGLKEKIELAKKEGAT 358 Query: 406 VVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVG 465 V G + P + +VT DM EE FGPL V+K D E A +ANA+D G Sbjct: 359 VQVEG---PIEGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHAAELANASDFG 415 Query: 466 LAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGIDEY 524 L+ +S+D + + A Q++ GMV +N+ ++ FGG K SGLGR + I+E+ Sbjct: 416 LSAAVWSKDIDRAAQFALQIDSGMVHINDLTVNDEPHVMFGGSKNSGLGRFNGDWAIEEF 475 Query: 525 LELKYV 530 +++ Sbjct: 476 TTDRWI 481 >5TJR-A nrPDB Length = 531 Score = 471 bits (1212), Expect = e-133, Method: Composition-based stats. Identities = 135/481 (28%), Positives = 230/481 (47%), Gaps = 14/481 (2%) Query: 62 DSFVGGRWL-PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120 +GG + T V +P++G A+ V + A+ AA AF WR +R Sbjct: 38 KHLIGGELIADTGRTADVFNPSTGEAVRKVPLADRETMQQAIDAAKAAFPAWRNTPPAKR 97 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180 + +L ++ L+ N++ + ++I+ E GK +++A GE+ +E+ + + G+ Sbjct: 98 AQVLFRFKQLLEANEERIVKLISEEHGKTIEDAAGELKRGIENVEYATAAPEILKGEYSR 157 Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240 + A QPIGV A ITP+NFP+ + A+A G T ++KP+E P S L + Sbjct: 158 NVGPNIDAWSDFQPIGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTLLI 217 Query: 241 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 300 AEL +AG+P GV NV+ + +A+ P V +SF GST + + Sbjct: 218 AELFHEAGLPKGVLNVVHGDKG----AVDALIEAPEVKALSFVGSTPIAEYIYSEGTKRG 273 Query: 301 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSN-QFLVQRGIHDAFVKA 359 KRV G ++ A++D AV+ M + + + G+ C+ + V I DA V+ Sbjct: 274 KRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQIADALVQK 333 Query: 360 FAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN- 418 + K L++G G G GPL+ A +KV ++ V++GA +V G+ +++ + Sbjct: 334 LVPQI-KGLKIGAGTSCGLDMGPLVTGAARDKVTGYIDTGVAQGAELVVDGRGYKVAGHE 392 Query: 419 ---FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 475 F TL VT +M EE FGP+ +++ ++ EEA+ + N + G +++D Sbjct: 393 NGFFLGGTLFDRVTPEMTIYKEEIFGPVLCIVRVNSLEEAMQLINDHEYGNGTCIFTRDG 452 Query: 476 AQIWRVAEQLEVGMVGVNEG-LISSVECPFGGVKQSGLG--REGSKYGIDEYLELKYVCY 532 +++EVGMVGVN + FGG K+S G G+ Y + K + Sbjct: 453 EAARLFCDEIEVGMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTKRKAITQ 512 Query: 533 G 533 Sbjct: 513 R 513 >3VZ0-A nrPDB Length = 459 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 152/457 (33%), Positives = 236/457 (51%), Gaps = 7/457 (1%) Query: 78 VQDPASGAALGMVADCGVREARAAVRAAYEAFCR-WREVSAKERSSLLRKWYNLMIQNKD 136 +P + + + A + W+ S +R ++ + +L+ +++ Sbjct: 9 TLNPTTETVERSFDLHTPAQMKDITDRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDRQ 68 Query: 137 DLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIG 196 A +I E GK L +A EI +A L +++ A K +A ++ QP+G Sbjct: 69 HHASLIATEMGKALPDALEEIDVTADILSFYANGAEEFLAPT-PLKVKTGQAKIINQPLG 127 Query: 197 VAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNV 256 + I PWNFP + R G L AG V+ K A + P ALA +L AG P G Y Sbjct: 128 IIYCIEPWNFPYYQLARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYAN 187 Query: 257 IPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVF 316 I + E + D + ++ TGS G+ + A ++K+ +MELGG FIV Sbjct: 188 IFLDNDQSAE----LIKDERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVL 243 Query: 317 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 376 D A++D AV A+ +F N GQ C + + +V ++DAF+ A+ + R+GN + Sbjct: 244 DDADLDLAVKWAVWGRFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRF-RIGNPLDR 302 Query: 377 GTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTH 436 TT GP+ + +A+E Q +AV GAT+V GGKR F EPT+L +V++D + Sbjct: 303 DTTHGPMSSLRAMELALDQTAEAVKGGATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFY 362 Query: 437 EETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL 496 +E FGP+A V K +E+ AI +AN + GL G +S+D A+ +VAEQ+E GMV +N Sbjct: 363 QEIFGPVAVVHKVASEQAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINTAT 422 Query: 497 ISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 ++ E PFGG+K SG GRE S GI+E++ K V G Sbjct: 423 AAAPELPFGGIKNSGFGRELSFLGIEEFINRKLVRIG 459 >4YWE-A nrPDB Length = 487 Score = 465 bits (1198), Expect = e-131, Method: Composition-based stats. Identities = 165/483 (34%), Positives = 249/483 (51%), Gaps = 13/483 (2%) Query: 58 LLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC-RWRE 114 + F+ G W A T PV DP+ G +A + AV AA +AF W Sbjct: 9 MEEAKHFIAGEWTLPAQLETIPVVDPSDGQPFATIARGTAPDIERAVAAARDAFAGPWGA 68 Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRV 174 SA ER +L + + + ++LA I ++GKPLK+A + A + E+++ A ++ Sbjct: 69 ASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAALARYFEFYAGAADKL 128 Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234 +G+ + A L +++P GV I PWN+P + R VGAALAAG VVKPAED Sbjct: 129 HGETLPYQA-GYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAEDAC 187 Query: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294 S L +AELA++AG+P+G N++ E G A+ P + ISFTGS TGK++ Sbjct: 188 LSVLRVAELAAEAGLPAGALNIVTGY---GHEAGAALARHPGIDHISFTGSPATGKLVTQ 244 Query: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 AA + V++ELGG +P IVF A++D A+ +++ +N GQTC ++ L++R +++ Sbjct: 245 MAAENHVPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYE 304 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 V+ A A LRVG GPLIN K ++V ++DA G + G+ Sbjct: 305 PLVERLATAF-NGLRVG-PSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVA 362 Query: 415 LG---KNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFY 471 + P LL +V EE FGP+ ++F E+EA+A+AN GL + Sbjct: 363 DAPESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIW 422 Query: 472 SQDPAQIWRVAEQLEVGMVGVNEG-LISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 ++D A+ R+A +L G V +N VE PFGGV SG GRE + + LK + Sbjct: 423 TRDGARQMRLARRLRAGQVFINNYGAGGGVELPFGGVGHSGHGREKGFEALYGFTALKTI 482 Query: 531 CYG 533 Sbjct: 483 AIR 485 >3EFV-A nrPDB Length = 462 Score = 465 bits (1197), Expect = e-131, Method: Composition-based stats. Identities = 138/453 (30%), Positives = 242/453 (53%), Gaps = 6/453 (1%) Query: 78 VQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDD 137 +PA+G L + +E A+ A F +W+ S +R+ LR + + ++ Sbjct: 11 SVNPATGQTLAAMPWANAQEIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEE 70 Query: 138 LARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGV 197 +A+ IT E GKP+K+A E+ SA +W++E + T ++++A++ +P+GV Sbjct: 71 MAQCITREMGKPIKQARAEVTKSAALCDWYAEHGPAMLNPE-PTLVENQQAVIEYRPLGV 129 Query: 198 AAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVI 257 I PWNFP + R L AG + ++K A + A +A + ++AG P+GVY + Sbjct: 130 ILAIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWV 189 Query: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 317 + + + + DP ++ ++ TGS G + A ++K+ +ELGG PFIV + Sbjct: 190 NANNEGVSQ----MINDPRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLN 245 Query: 318 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEG 377 A+++ AV A+A +++NTGQ C + +F+V+ GI AF F A L++G+ E Sbjct: 246 DADLELAVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDRFV-AAAAALKMGDPLVEE 304 Query: 378 TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 437 GP+ +++ +QV +V++GA ++ GG++ N++ T+L +VT DM + Sbjct: 305 NDLGPMARFDLRDELHQQVQASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFRQ 364 Query: 438 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLI 497 E FGP+A + A+A+AN ++ GL+ ++ D +A +LE G V +N Sbjct: 365 ELFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFINGYSA 424 Query: 498 SSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 S FGGVK+SG GRE S +G+ E+ ++ V Sbjct: 425 SDARVAFGGVKKSGFGRELSHFGLHEFCNVQTV 457 >5KF0-A nrPDB Length = 485 Score = 465 bits (1196), Expect = e-131, Method: Composition-based stats. Identities = 151/477 (31%), Positives = 237/477 (49%), Gaps = 17/477 (3%) Query: 64 FVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 ++ + A V D SG VA + AA+ AA +A RE+ A R ++ Sbjct: 17 YLANEAVYANTDLEVTDKFSGKVATRVALADAQAIDAAIGAAVDAVKPMRELPAYRRQAV 76 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI----I 179 L + D+LA + E+GKP+ ++ GE+ SEEA R+ G++ I Sbjct: 77 LDHCVARFRERFDELAEALCIEAGKPINDSRGEVTRLIDTFRVASEEAVRIDGEVLNLEI 136 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 A+ + PIG + I+P+NFP + KV ALAAGC V+KPA TP AL Sbjct: 137 SARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALI 196 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 +AE+ ++ +P G ++V+P R A + TD +SFTGS G L A Sbjct: 197 IAEVLAETNLPKGAFSVLPAHRDGA----DLFTTDERFRLLSFTGSPAVGWALKEKAGK- 251 Query: 300 VKRVSMELGGLAPFIVFDSA--NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 K+V +ELGG A IV +D V + +GQ+C+ + LV ++D Sbjct: 252 -KKVVLELGGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSCIGVQRILVHASLYDTLR 310 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 A ++L++G+ + T GP+I+E ++ ++ AV+ GA ++ GGK + Sbjct: 311 DKLV-AKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIIAGGK---VDG 366 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 FE TLL +V ++ +E FGP+A + KFD ++A+A N +D GL ++ Sbjct: 367 AMFEATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDSDFGLQAGVFTDSLTH 426 Query: 478 IWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 R ++LEVG V +N+ V+ P+GGVK SGLGREG +Y I++ E + + Sbjct: 427 AQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLMVVR 483 >3PRL-A nrPDB Length = 505 Score = 463 bits (1193), Expect = e-131, Method: Composition-based stats. Identities = 148/487 (30%), Positives = 240/487 (49%), Gaps = 18/487 (3%) Query: 50 RLAGLSAALLRTDSFVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYE 107 + L + G W+ + + PASG ALG + E A++ A + Sbjct: 1 MVMALQTEQFNANILRNGEWVESRTGERISISAPASGVALGSIPALSQEEVNDAIQGAKD 60 Query: 108 AFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWF 167 A W+ ER LL W +L+ + K+ + +I E KP K A GE+ +A + Sbjct: 61 AQKIWKIRPIHERVDLLYAWADLLEERKEIIGELIMHEVAKPKKSAIGEVSRTADIIRHT 120 Query: 168 SEEARRVYGDIIHTP-----AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAG 222 ++EA R+ G+ + + + ALV ++P+GV I+P+N+P + K+ AL G Sbjct: 121 ADEALRLNGETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVNLAAAKIAPALVTG 180 Query: 223 CTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 282 TVV KPA S + + E + AG P G+ V+ +G+ + P + I+F Sbjct: 181 NTVVFKPATQGSLSGIKMVEALADAGAPEGIIQVVTG---RGSVIGDHLVEHPGIDMITF 237 Query: 283 TGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC 342 TG TTTG+ + A + V +ELGG P IV D A++ + ++ F +GQ C Sbjct: 238 TGGTTTGERISEKA--KMIPVVLELGGKDPAIVLDDADLKLTASQIVSGAFSYSGQRCTA 295 Query: 343 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK 402 + VQ + D V E +++ L VG+ E+ P+I+EK+ ++ ++DA+ Sbjct: 296 IKRVFVQDSVADQLVANIKELVEQ-LTVGSP-EDDADITPVIDEKSAAFIQGLIDDALEN 353 Query: 403 GATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAA 462 GAT+++G KR N PTLL +VT M EE FGP+ P+I+ EAI+++N + Sbjct: 354 GATLLSGNKRQ---GNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAISLSNQS 410 Query: 463 DVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVEC-PFGGVKQSGLGREGSKYGI 521 D GL +++D + + + LEVG V +N + PF GVK+SGLG +G K + Sbjct: 411 DYGLQASIFTKDTDRAINIGKHLEVGTVHINAKTERGPDHFPFLGVKKSGLGVQGIKPSL 470 Query: 522 DEYLELK 528 + Sbjct: 471 LSMTRER 477 >5UR2-A nrPDB Length = 984 Score = 463 bits (1192), Expect = e-131, Method: Composition-based stats. Identities = 144/472 (30%), Positives = 241/472 (51%), Gaps = 16/472 (3%) Query: 65 VGGRWLPAAATFPVQDPA-SGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 + + L + F +P+ S +G + +A A++AA A+ W+ V ++R++L Sbjct: 501 INNKELQSGKIFDRVNPSQSDQIVGKIQMATTEQAEQAMQAAQTAYKTWKNVPCEQRAAL 560 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPA 183 + K ++M +++ L E GKP EA G+I + F +++ R + + Sbjct: 561 VDKLADIMTRDRFKLIATQVLEVGKPWAEADGDIGEAIDFCRYYARHMRELQKPLRVGGL 620 Query: 184 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL 243 + + + GV AVI PWNFP A++ V AA AG TVV+KPAE + A L ++ Sbjct: 621 PGELSHYIYKSRGVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQSTVVAWGLMKM 680 Query: 244 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA------ 297 +AG P GV N +P +EVGE I + I+FTGS G +++ AA Sbjct: 681 IQEAGFPQGVINFLPGY---GEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAAVVQPGQ 737 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 VKR +E+GG I+ + A++D+AV G + S F +GQ C +++ +V ++D FV Sbjct: 738 QHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDEVYDRFV 797 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 E K++ + GP+++++A +++ + +A K ++ G G Sbjct: 798 DRLVE-TAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEA-EKNHKLLFKGSVPG-GG 854 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F PT+ +V D E FGP+ VI+ ++A+ IAN+ + L G +S+ PA Sbjct: 855 FFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFSRSPAN 914 Query: 478 IWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLG-REGSKYGIDEYLE 526 I RV E+LEVG + VN G+ ++ PFGG K SG+G + G + +Y+E Sbjct: 915 INRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDYLKQYME 966 >3ROS-A nrPDB Length = 484 Score = 462 bits (1189), Expect = e-130, Method: Composition-based stats. Identities = 130/454 (28%), Positives = 214/454 (47%), Gaps = 8/454 (1%) Query: 74 ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQ 133 + + +P + A + ++ A+ A+ + +WR R+ +L N + + Sbjct: 4 SKYQSVNPYTNEAFASYDNPTSKQIDEAINLAHALYKKWRHEEPASRAEILHDIANALKE 63 Query: 134 NKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQ 193 ++D+LA+++T E GK L E+ E+ ++++ + A LKQ Sbjct: 64 HEDELAKMMTLEMGKLLSESKEEVELCVSICNYYADHGPEMLKPTKLNSDLGN-AYYLKQ 122 Query: 194 PIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSG- 252 GV PWNFP + R G +++K A + P SA A++ +AG P G Sbjct: 123 STGVIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGS 182 Query: 253 VYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAP 312 + N+ P + A I DP + ++ TGS G + A ++K+ +MELGG Sbjct: 183 LINLYPSYDQLAD-----IIADPRIQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDA 237 Query: 313 FIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGN 372 FIV D A+ ++ N GQ C S + +V++ +D + NL+ G+ Sbjct: 238 FIVLDDADPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFS-NLKAGD 296 Query: 373 GFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDM 432 E TT P+ +EKA EK+E QV +A+ GA V FF PT+L ++ +D Sbjct: 297 PLEADTTLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDN 356 Query: 433 LCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGV 492 +E FGP+A V + + AI +AN + GL D + +V+ Q+E GM + Sbjct: 357 PVFDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVI 416 Query: 493 NEGLISSVECPFGGVKQSGLGREGSKYGIDEYLE 526 N I+S E PFGG+K+SG GRE S G+ ++ Sbjct: 417 NGRWITSGELPFGGIKKSGYGRELSGLGLMAFVN 450 >5N5S-A nrPDB Length = 515 Score = 458 bits (1180), Expect = e-129, Method: Composition-based stats. Identities = 153/467 (32%), Positives = 245/467 (52%), Gaps = 17/467 (3%) Query: 74 ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQ 133 V + + V ++ A+ AA A + A ER ++L K + Sbjct: 54 KWLDVTNKYTNDVAAKVPQATHKDIDDAIDAAVAAAPAMAAMGAYERKAVLEKVVAELKN 113 Query: 134 NKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTP----AKDRRAL 189 +++A+ +T ESGKP+K+A GE+ + + +EE+ R+YG+ I K + + Sbjct: 114 RFEEIAQTLTMESGKPIKDARGEVTRTIDTFQVAAEESVRIYGEHIPLDISARNKGLQGI 173 Query: 190 VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA-G 248 V K PIG ++++PWNFP ++ KV A+A GC V+KPA TP SAL L E+ + Sbjct: 174 VKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKIEE 233 Query: 249 IPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG 308 +P G ++++P SR++A + D ++FTGS G + A K+V MELG Sbjct: 234 LPLGAFSILPVSREDA----DMFTVDERFKLLTFTGSGPIGWDMKARAGK--KKVVMELG 287 Query: 309 GLAPFIVFD-SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKN 367 G AP IV D ++D + + F GQ+C+ + V ++D + F A+KK Sbjct: 288 GNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDEVKEGFVAAVKK- 346 Query: 368 LRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 427 L++GN FEE T GP+I+E A + +E V +AV+KG ++TGG R F EPT++ + Sbjct: 347 LKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGGNR---KGAFIEPTVIED 403 Query: 428 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 487 V + EE FGP+ + K+ +EA+ N GL +++D + + E +EV Sbjct: 404 VPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNKAFYAFEHMEV 463 Query: 488 GMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 G V +N+ V+ P+GG+K SG+ REG KY +D+ LE K + Sbjct: 464 GGVILNDSPALRVDSQPYGGLKDSGIQREGVKYAMDDMLETKVLVMR 510 >3VZ3-A nrPDB Length = 457 Score = 458 bits (1180), Expect = e-129, Method: Composition-based stats. Identities = 135/455 (29%), Positives = 213/455 (46%), Gaps = 6/455 (1%) Query: 76 FPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNK 135 +P +G E A + A EAF +R S +R L ++ ++ Sbjct: 6 IATINPTTGEICQRFKALTPAEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDT 65 Query: 136 DDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPI 195 A I+T E GK + A E SA +++E + + +T + + V QP+ Sbjct: 66 SKFAEIMTTEMGKTHQSAIAEAEKSALVCRYYAEHGEQFLANE-YTETQATESYVCYQPL 124 Query: 196 GVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYN 255 G+ + PWNFP + R AL AG V+K A + P ALA+ + AG P GV+ Sbjct: 125 GILLAVMPWNFPFWQVFRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQ 184 Query: 256 VIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIV 315 + E + DP V + TGS G L A +K +ELGG PF+V Sbjct: 185 TLLI----GASQVEQVIKDPRVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVV 240 Query: 316 FDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFE 375 F SA++D+AV ++ N GQ+ + + +F++ I F++ +L++G+ Sbjct: 241 FPSADLDEAVEVGTVARTMNNGQSAIAAKRFILHEAIAAEFLEKLHLKFA-SLKIGDPMA 299 Query: 376 EGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCT 435 T GPL E ++ + +QV+ AV+ GA ++ GG+ F+ PT+L + Sbjct: 300 PETDIGPLATEGILQDISRQVDQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKIL 359 Query: 436 HEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEG 495 EE F P+A V ++AIA+AN GL ++ DPA+ R ++L+ G V +N Sbjct: 360 QEELFAPVAMVFTVKDLDQAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGM 419 Query: 496 LISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530 + S PFGG K+SG GRE GI ++ K V Sbjct: 420 VKSDPRLPFGGTKRSGYGRELGLAGIRTFVNAKTV 454 >5JRY-A nrPDB Length = 485 Score = 458 bits (1179), Expect = e-129, Method: Composition-based stats. Identities = 156/477 (32%), Positives = 238/477 (49%), Gaps = 17/477 (3%) Query: 64 FVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 ++ + A V D SG VA + AA+ AA +A RE+ A +R ++ Sbjct: 17 YLANAAVYANTDLEVTDKYSGKVATRVALADAKAIDAAIGAAVDATKPMRELPAYKRQAV 76 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI----I 179 L + D+LA + E+GKP+ +A GE+ SEEA R+ G++ I Sbjct: 77 LDHCVARFRERFDELAEALCIEAGKPINDAKGEVTRLIDTFRVASEEAVRIDGEVLNLEI 136 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 A+ + PIG + I+P+NFP + KV ALAAGC V+KPA TP AL Sbjct: 137 SARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALI 196 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 + E+ ++ +P G ++V+P R A + TD +SFTGS G L A Sbjct: 197 IGEVLAETDLPKGAFSVLPAHRDGA----DLFTTDDRFRLLSFTGSPAVGWALKEKAGK- 251 Query: 300 VKRVSMELGGLAPFIVFDSA--NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 K+V +ELGG A IV +D V F +GQ+C+ + L I+DA Sbjct: 252 -KKVVLELGGNAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIGVQRILAHADIYDALR 310 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 A ++L++G+ + T GP+I+E ++ ++ AV+ GA +V GGK + Sbjct: 311 DKLI-AKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIVAGGK---VDG 366 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 FE TLL NV +D +E FGP+A + KFD ++A+A N +D GL ++ A Sbjct: 367 AMFEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSDFGLQAGVFTDSLAH 426 Query: 478 IWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 + ++LEVG V +N+ V+ P+GGVK SGLGREG +Y I++ E + + Sbjct: 427 TQQAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLLVVR 483 >4OGD-A nrPDB Length = 465 Score = 453 bits (1166), Expect = e-128, Method: Composition-based stats. Identities = 133/447 (29%), Positives = 213/447 (47%), Gaps = 7/447 (1%) Query: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVS-AKERSSLLRKWYNLMIQNKDDLA 139 P + L + + + A+ + +WR+ +ER + L + N++ +++D A Sbjct: 8 PYTNEVLHTFDNMTDQGLADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYA 67 Query: 140 RIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199 I+T + GK EA GE+ A ++++++A +A LKQ GV Sbjct: 68 EIMTKDMGKLFTEAQGEVDLCADIADYYADKADEFL-MSTPLETDSGQAYYLKQSTGVIL 126 Query: 200 VITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPC 259 + PWNFP I R G +V+K A P SA + EL +AG +G + Sbjct: 127 AVEPWNFPYYQIMRVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFI 186 Query: 260 SRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSA 319 S +V D V + TGS G + A ++K+ ++ELGG FI+ D A Sbjct: 187 SYDQVSQV----IADKRVVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDA 242 Query: 320 NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTT 379 + DQ S+ N GQ C S +F+V +D F + + K + G+ + TT Sbjct: 243 DWDQLEKVLYFSRLYNAGQVCTSSKRFIVLDKDYDRFKE-LLTKVFKTAKWGDPMDPETT 301 Query: 380 QGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEET 439 PL + +A V Q+ A+ GA +V GG+ +F PT++ +T+D ++E Sbjct: 302 LAPLSSAQAKADVLDQIKLALDHGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEI 361 Query: 440 FGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISS 499 FGP+ + K +EEEAI +AN ++ GL G +S + VA ++E GM +N G S Sbjct: 362 FGPVGEIYKVSSEEEAIEVANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWTSL 421 Query: 500 VECPFGGVKQSGLGREGSKYGIDEYLE 526 E PFGG+K SG GRE S+ G ++ Sbjct: 422 PELPFGGIKHSGYGRELSELGFTSFVN 448 >6MVR-A nrPDB Length = 767 Score = 453 bits (1165), Expect = e-127, Method: Composition-based stats. Identities = 156/492 (31%), Positives = 240/492 (48%), Gaps = 30/492 (6%) Query: 36 GPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGV 95 GPAP A+ YA LA F+GG W F +PA+G L V+ Sbjct: 14 GPAPESAK-EAYA-WLAEKG----DFGHFIGGAWTAPGDLFATVNPATGQTLAQVSQATQ 67 Query: 96 REARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG 155 + AAV+AA +A W + R+ +L L+ ++ A + T ++GKP++EA Sbjct: 68 ADVDAAVKAARKAQPAWAK-DGAARARVLYALARLLQKHARLFAVLETLDNGKPIREARD 126 Query: 156 -EILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRK 214 ++ + + A ++ T D + P+GV + PWNFP M+ K Sbjct: 127 IDVPLAQRHFYHHAGYA-----QLMGTEMPD------RAPLGVCGQVIPWNFPLLMLAWK 175 Query: 215 VGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTD 274 + ALA G TVV+KPAE TP +AL A++ QAG+P+GV N++ VGE I T Sbjct: 176 IAPALAMGNTVVLKPAEWTPLTALLFADICGQAGVPAGVVNIVTG----DGAVGEMIVTA 231 Query: 275 PLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFR 334 V K++FTGST G+ + A + K +S+ELGG P++V D A++D AV G + + + Sbjct: 232 Q-VDKVAFTGSTAVGRRIREATAGTGKALSLELGGKGPYVVCDDADIDSAVEGLVDAIWF 290 Query: 335 NTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEK 394 N GQ C ++ LVQ GI D F M +LR+G+ ++ G +++ + +V Sbjct: 291 NQGQVCCAGSRLLVQEGIADVFHAKLRARM-DSLRIGDPLDKCIDIGAMVHPDQLARVRD 349 Query: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454 V A + G + ++ PTL+ + +E FGP+ F T E Sbjct: 350 MV-AANTDGEV----YQTAVPAGCYYPPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAE 404 Query: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGR 514 A+ IAN GLA +S++ +A +L G+V +N + PFGGV++SG GR Sbjct: 405 AVEIANNTAYGLAASVWSENVNLALDLAPKLVAGIVWINGTNMMDAAAPFGGVRESGFGR 464 Query: 515 EGSKYGIDEYLE 526 EG G+ Y Sbjct: 465 EGGWEGLAGYTR 476 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 121/312 (38%), Gaps = 22/312 (7%) Query: 1 MATCIWLRSCGARRLGSTFPGCRLRP--RAGGLVPASG---PA---PGPAQLRCYAGRLA 52 +A +W+ + F G R R GG +G PA PA + Y G A Sbjct: 436 VAGIVWINGTNMMDAAAPFGGVRESGFGREGGWEGLAGYTRPAIATKSPAAVAAYTGDGA 495 Query: 53 GLSAALLRTDSFVGGRWL--PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFC 110 ++GG+ + V P G LG + ++ R AV A A Sbjct: 496 A-DGLDRTAKLYIGGKQTRPDGGYSRAVYGPK-GKLLGHASLSNRKDLRNAVEAMNAA-S 552 Query: 111 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEE 170 W + R+ +L + D+ A I +GK + E+ S L + Sbjct: 553 GWSRTTGHLRAQILYFIGENLSARADEFANRIKDMTGK---DGKAEVAASIDRLFSAAAW 609 Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230 A + G + P + AL +K+P+G ++ P P + + A+A G V + + Sbjct: 610 ADKYDGQVKGVPLRG-VALAMKEPVGKIGILCPDAAPLLGLVSLMAPAIAMGNRVTLAAS 668 Query: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290 E P +A ++ + +P+GV N++ + ++ E + + + G + + Sbjct: 669 EAFPLAATDFYQVLDTSDVPAGVVNILTGAH---ADLAEPMARHLDLDAVW--GLSGHAQ 723 Query: 291 ILLHHAANSVKR 302 ++ +A ++KR Sbjct: 724 VIEAASAGNLKR 735 >2J5N-A nrPDB Length = 516 Score = 448 bits (1152), Expect = e-126, Method: Composition-based stats. Identities = 142/482 (29%), Positives = 228/482 (47%), Gaps = 21/482 (4%) Query: 63 SFVGGRWLPAAATFPVQDP-ASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERS 121 ++GG W+ +P A +G A G EA AA+ AA++AF W++ ++RS Sbjct: 40 LYIGGEWVDTKERMVSLNPSAPSEVVGTTAKAGKAEAEAALEAAWKAFKTWKDWPQEDRS 99 Query: 122 SLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG---DI 178 LL K LM + K +L + E GK EA ++ + F+E+++ A R ++ Sbjct: 100 RLLLKAAALMRRRKRELEATLVYEVGKNWVEASADVAEAIDFIEYYARAALRYRYPAVEV 159 Query: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238 + P +D + + P+G VI PWNFP A+ T + +A G TV+ KPAED Sbjct: 160 VPYPGEDNESFYV--PLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVIAKPAEDAVVVGA 217 Query: 239 ALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298 + E+ +AG P GV N +P +EVG + P + I+FTGS G + A Sbjct: 218 KVFEIFHEAGFPPGVVNFLPGV---GEEVGAYLVEHPRIRFINFTGSLEVGLKIYEAAGR 274 Query: 299 S------VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 KR +E GG IV ++A+ D A G + S + GQ C +++ ++ +G Sbjct: 275 LAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAASRLILTQGA 334 Query: 353 HDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKR 412 ++ ++ + + L VG EE GP+++ + KV + ++G +V GGKR Sbjct: 335 YEPVLERVLKR-AERLSVG-PAEENPDLGPVVSAEQERKVLSYIEIGKNEGQ-LVLGGKR 391 Query: 413 HQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 + F PT+ V EE FGP+ VI+ EA+ +AN GL G YS Sbjct: 392 LEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPYGLTGGVYS 451 Query: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVEC--PFGGVKQSG-LGREGSKYGIDEYLELKY 529 + + + VG + N + ++ PFGG K SG + G+ + +LE+K Sbjct: 452 RKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYLRLFLEMKA 511 Query: 530 VC 531 V Sbjct: 512 VA 513 >5J6B-A nrPDB Length = 485 Score = 446 bits (1148), Expect = e-126, Method: Composition-based stats. Identities = 145/477 (30%), Positives = 234/477 (49%), Gaps = 17/477 (3%) Query: 64 FVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 123 ++ + A A V D +G VA AA+ AA A R + A R ++ Sbjct: 17 YLANEAVYANAELEVTDKYTGKVATRVALADASAIDAAIAAAVGAQKPLRALPAFRRQAI 76 Query: 124 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTP- 182 L + D+LA+ + E+GKP+ ++ GE+ +EE+ R+ G +++ Sbjct: 77 LEHCVARFRERFDELAQALCIEAGKPINDSKGEVTRLIDTFRVAAEESVRIEGGLVNLEI 136 Query: 183 ---AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 A+ + PIG + I+P+NFP + KV ALAAGC V+KPA TP AL Sbjct: 137 SPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIGALI 196 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 + E+ ++ +P G ++++P R A + TD +SFTGS T G L A Sbjct: 197 IGEVLAETDLPKGAFSILPAHRDGA----DLFTTDERFKLLSFTGSPTVGWELKKKAGKK 252 Query: 300 VKRVSMELGGLAPFIVFDSAN--VDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 V +ELGG A IV +D V + +GQ+C+ + + ++DA Sbjct: 253 K--VVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRIIAHADVYDALR 310 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 + A ++L++G+ + T GP+I+E ++ + AV+ GA +V GGK + Sbjct: 311 EKLI-AKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKIVAGGK---VDG 366 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 FE TLL V +D +E FGP+A + +F ++A+A N +D GL ++ + Sbjct: 367 AMFEATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGLQAGVFTDSLSH 426 Query: 478 IWRVAEQLEVGMVGVNEGLISSVE-CPFGGVKQSGLGREGSKYGIDEYLELKYVCYG 533 R ++LEVG V +N+ V+ P+GGVK SGLGREG +Y I++ EL+ + Sbjct: 427 AQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELRLMVVR 483 >5U0M-A nrPDB Length = 497 Score = 441 bits (1136), Expect = e-124, Method: Composition-based stats. Identities = 137/470 (29%), Positives = 220/470 (46%), Gaps = 11/470 (2%) Query: 57 ALLRTDSFVGGRWLPA-AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREV 115 A L + ++ G WLP A F P +G + + + AAVR A +AF WR Sbjct: 8 ANLTGNVYIDGLWLPGHGAPFESVQPVTGETVWDGNAASLEDVDAAVREARKAFLAWRRK 67 Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVY 175 S ER +++ + L+ NK++LA I E+GKPL E+ E+ + + Sbjct: 68 SLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESRTEVAAMMGKIPISVKAYNERT 127 Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235 G + A++ +P GV AV P+NFP + + AL AG TVV KP+E TP Sbjct: 128 GHT-ESDVAGGHAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPG 186 Query: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295 A L +AG+P GV N++ + + G+ + L+ + FTGS+T G +L Sbjct: 187 VAELTVRLWEKAGLPDGVINLV----QGGSDTGKCLARHSLIDGLFFTGSSTVGHLLHEQ 242 Query: 296 AANSVKRV-SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH- 353 +++ ++E+GG P IV + +++D AV A+ S F + GQ C C+ + LV +G Sbjct: 243 FGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAFLSAGQRCTCARRLLVPKGKKG 302 Query: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413 D F+ E + + G +I+ +A ++ K + KGAT + K+ Sbjct: 303 DEFLARLVEVAARITVAEFDADPQPFMGSVISAEAANQLLKAQAAMLEKGATSLLEMKQL 362 Query: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + P ++ + +E FGPL V ++ +EA+ +AN GL+ S Sbjct: 363 KPDTGLLSPGIVD--ATGIELEDQEFFGPLLTVYRYKGFDEALELANNTRYGLSAGILSD 420 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGID 522 D R+ E++ G+V N L + PFGGV SG R + Y D Sbjct: 421 DRKLYNRLVEEVRAGIVNWNRPLTGASSAAPFGGVGASGNHRPSAYYAAD 470 >4E4G-A nrPDB Length = 521 Score = 433 bits (1114), Expect = e-122, Method: Composition-based stats. Identities = 121/488 (24%), Positives = 222/488 (45%), Gaps = 15/488 (3%) Query: 54 LSAALLRTDSFVGGRWLPAAATF--PVQDPASGAALGMVADCGVREARAAVRAAYEAFCR 111 + + F+ G+ + + + +PA+G G VA + AAV +A A + Sbjct: 20 FQSMMYELGHFIDGKRVAGTSGRVSNIFNPATGEVQGTVALASDADLAAAVESAKAAQPK 79 Query: 112 WREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEA 171 W + + R+ + K+ L+ N ++LA +++ E GK + +A G+I+ E+ Sbjct: 80 WAATNPQRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDAKGDIVRGLEVCEFVIGIP 139 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 + ++QP+G+ A ITP+NFP + A+A G ++KP+E Sbjct: 140 HLQKSEFTEGAGPGIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSE 199 Query: 232 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 P + LAEL +AG+P+G+ NV+ + +AI T P ++ +SF GST + Sbjct: 200 RDPSVPIRLAELMIEAGLPAGILNVVNGDKG----AVDAILTHPDIAAVSFVGSTPIARY 255 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL-VQR 350 + AA + KR G I+ A++DQA + + + + G+ C+ + + V Sbjct: 256 VYGTAAMNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGE 315 Query: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 + + M ++LR+G +E GP++ ++A +++ ++ + +GA +V G Sbjct: 316 ETANRLIDKLV-PMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDG 374 Query: 411 KRHQLGKN----FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGL 466 + +L F L +VT DM E FGP+ V++ EEA+++ + G Sbjct: 375 RDFKLQGYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGN 434 Query: 467 AGYFYSQDPAQIWRVAEQLEVGMVGVNEG-LISSVECPFGGVKQSGLG--REGSKYGIDE 523 Y++D A ++ +GMVGVN + FGG K S G + I Sbjct: 435 GVAIYTRDGDAARDFASRINIGMVGVNVPIPVPLAYHSFGGWKSSSFGDLNQHGTDSIKF 494 Query: 524 YLELKYVC 531 + K + Sbjct: 495 WTRTKTIT 502 >1UXV-A nrPDB Length = 501 Score = 432 bits (1111), Expect = e-121, Method: Composition-based stats. Identities = 141/480 (29%), Positives = 229/480 (47%), Gaps = 20/480 (4%) Query: 63 SFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRW--REVSAKER 120 S++ G W + V+ P A + V E + ++ RW R++ ER Sbjct: 21 SYLAGEWGGSGQEIEVKSPIDLATIAKVISPSREEVERTLDVLFKR-GRWSARDMPGTER 79 Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180 ++LRK +++ +N D A ++ +GKP A GE+ + L + +++ GD I Sbjct: 80 LAVLRKAADIIERNLDVFAEVLVMNAGKPKSAAVGEVKAAVDRLRLAELDLKKIGGDYIP 139 Query: 181 TPAK----DRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFS 236 + LV ++P+GV A ITP+N+P K+ + G VVVKP+ P Sbjct: 140 GDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSISDPLP 199 Query: 237 ALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 296 A + AG P ++ K A E I D V+ +SFTGST G+ ++ Sbjct: 200 AAMAVKALLDAGFPPDAIALLNLPGKEA----EKIVADDRVAAVSFTGSTEVGERVVKVG 255 Query: 297 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAF 356 VK+ MELGG P IV + A++D A + GQ C L +R ++ Sbjct: 256 G--VKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKL 313 Query: 357 VKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLG 416 V+ A+ + +LRVG+ + GPLI+ AV+++ + DAV KG V+ GG+R LG Sbjct: 314 VEEVAKRLS-SLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRR--LG 370 Query: 417 KNFFEPTLL---CNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473 + +PTL+ + +DM+ E F P+A ++ ++AI +AN GL + + Sbjct: 371 PTYVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVFGR 430 Query: 474 DPAQIWRVAEQLEVGMVGVNEGLISSV-ECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532 D +I R LEVG + +N+ + PFGG K+SG+ REG Y ++ K + + Sbjct: 431 DVVKIRRAVRLLEVGAIYINDMPRHGIGYYPFGGRKKSGVFREGIGYAVEAVTAYKTIVF 490 >6DBB-A nrPDB Length = 511 Score = 426 bits (1096), Expect = e-119, Method: Composition-based stats. Identities = 135/478 (28%), Positives = 226/478 (47%), Gaps = 25/478 (5%) Query: 68 RWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKW 127 +W A T + P GA L +A +A + AA++AF +WR V A R L+R + Sbjct: 24 QWKGNALT--ARSPLDGATLATLAVDTPADAERKIDAAHDAFLKWRTVPAPVRGELVRVF 81 Query: 128 YNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRR 187 N++ ++K +L R++T E+GK E GE+ ++ +R++YG I + R Sbjct: 82 GNVLREHKAELGRLVTLEAGKITSEGLGEVQEMIDICDFAVGLSRQLYGLTIASERPGHR 141 Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA 247 + PIGV VI+ +NFP A+ A G +VV KP+E TP +A+A L +A Sbjct: 142 MMETWHPIGVCGVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKA 201 Query: 248 G----------IPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAA 297 P+ + ++ R +VGE + V +S TGS G+ + + Sbjct: 202 LREFEKTHPGVAPAELGQLVLGMR----DVGEVLTASKKVPVVSATGSVRMGQEVAKVLS 257 Query: 298 NSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV 357 + R +ELGG IV SA++D V + GQ C + +V R + + + Sbjct: 258 QRLARGILELGGNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLL 317 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 +A +++VGN EEGT GPL++ + + ++K + DA +G V GG+R +G Sbjct: 318 PRIEKAYA-SVKVGNPLEEGTLVGPLVDRASFDAMQKALADAREQGGE-VKGGERVDVGH 375 Query: 418 ---NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 474 + P ++ + + ETF P+ V+ +D ++AI + NA GL+ ++ D Sbjct: 376 ADAYYVRPAIV-RMPKQSAVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTND 434 Query: 475 PAQIWRV--AEQLEVGMVGVNEGLISS-VECPFGGVKQSGLGREGSKYGIDEYLELKY 529 + + A + G+V VN G + + FGG K++G GRE Y+ Sbjct: 435 MREAEQFMSAAGSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRRAT 492 >4KNA-A nrPDB Length = 495 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 134/458 (29%), Positives = 215/458 (46%), Gaps = 10/458 (2%) Query: 61 TDSFVGGRWLPAAA-TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKE 119 T+ F+ G W+ A F ++P + + A + AV +A AF W + Sbjct: 10 TELFIDGAWVDGAGPVFASRNPGTNERVWEGASASADDVERAVASARRAFAAWSALDLDA 69 Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDII 179 R ++++++ L+++ K+ LA +I E+GKPL EA E+ A ++ G+ Sbjct: 70 RCTIVKRFAALLVERKEALATMIGRETGKPLWEARTEVASMAAKVDISITAYHERTGEK- 128 Query: 180 HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALA 239 P D A++ +P GV AV P+NFP + + AL AG TVV KP+E P A A Sbjct: 129 RAPMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARA 188 Query: 240 LAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANS 299 E+ AG+P+GV N++ + K+ G A+ + + FTGS+ TG +L Sbjct: 189 TVEIWRDAGLPAGVLNLV----QGEKDTGVALANHRQIDGLFFTGSSDTGTLLHKQFGGR 244 Query: 300 VKRV-SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH-DAFV 357 + V ++E+GG P +V + ++D AV A+ S F + GQ C C+ + LV RG D FV Sbjct: 245 PEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDRFV 304 Query: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417 A+ K + G +I+ +A ++ V GA+ + K+ Sbjct: 305 ARLADVASKITASVFDADPQPFMGAVISARAASRLVAAQARLVGLGASPIIEMKQRDPAL 364 Query: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477 F +L +VT EE FGPLA ++++ ++AIA AN GL+ + D Sbjct: 365 GFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLLADDEQA 423 Query: 478 IWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQSGLGR 514 + G+V N +S PFGG +SG R Sbjct: 424 WHTFRRAIRAGIVNWNRPTNGASSAAPFGGAGRSGNHR 461 >4I3V-A nrPDB Length = 488 Score = 413 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 133/488 (27%), Positives = 228/488 (46%), Gaps = 22/488 (4%) Query: 52 AGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR 111 A ++ A+ + GR + V+ P + +G V AR A A Sbjct: 7 AEVTIAVRHEPMRIAGRLVDTDDRVEVRYPWNDTVVGTVPAGRAEHAREAFAIAAAYQP- 65 Query: 112 WREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEA 171 +++ ER +L + K++++ +IT E G ++ E+ + + Sbjct: 66 --KLTRYERQKILLATAEALAARKEEISDVITLELGISKADSLYEVGRAFDVFTLAGQMC 123 Query: 172 RRVYGDIIHTP----AKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVV 227 R G+I K R+ +++P+ + ITP+N P M+ KV A+A VVV Sbjct: 124 IRDDGEIFSCDLTPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVV 183 Query: 228 KPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287 KP E TP +AL LA++ +AG+P + +V+ ++G + T+P V ++FTGS Sbjct: 184 KPTELTPMTALLLADILYEAGLPPEMLSVVTGW---PADIGMEMITNPHVDLVTFTGSVP 240 Query: 288 TGKILLHHAANSVKRVSMELGGLAPFIVFDSA---NVDQAVAGAMASKFRNTGQTCVCSN 344 GK++ +A KR +ELGG P I+ + ++ +A A+A +N+GQ C Sbjct: 241 VGKLIAANA--HYKRQVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVK 298 Query: 345 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 404 + L Q + D FV E K LR G+ + T G +I+EKA E++V A +GA Sbjct: 299 RILCQESVADRFVPLVLER-AKRLRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGA 357 Query: 405 TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEA-IAIANAAD 463 ++ R P ++ V EETFGP+ P+++ +++A I ++N+ Sbjct: 358 DILYHPGR---SGALLPPIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTA 414 Query: 464 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVEC-PFGGVKQSGLG-REGSKYGI 521 GL+ + D ++ + L+VG V + E +E PFGG+K SG G +EG + Sbjct: 415 FGLSSGVCTNDYRRMQKYIAGLKVGTVNIWEVPGYRIEMSPFGGIKDSGNGYKEGVIEAM 474 Query: 522 DEYLELKY 529 + +K Sbjct: 475 KSFTNVKT 482 >3JU8-A nrPDB Length = 490 Score = 411 bits (1058), Expect = e-115, Method: Composition-based stats. Identities = 141/465 (30%), Positives = 216/465 (46%), Gaps = 13/465 (2%) Query: 55 SAALLRTDSFVGGRWLPA-AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 S A++ T ++ G+WL T DP + + AAV AA EAF W Sbjct: 1 SNAMMST-HYIAGQWLAGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWA 59 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 ++R LL ++ + D+LAR+I E+GKPL E+ E+ + + R Sbjct: 60 RRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRE 119 Query: 174 VYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233 G+ P D A++ +P GV AV P+NFP + + AL AG VV KP+E T Sbjct: 120 RTGEK-SGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELT 178 Query: 234 PFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILL 293 P A + QAG+P+GV N++ + +E G A+ + + FTGS+ TG +L Sbjct: 179 PKVAELTLKAWIQAGLPAGVLNLV----QGGRETGVALAAHRGLDGLFFTGSSRTGNLLH 234 Query: 294 HHAANSVKRV-SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGI 352 +++ ++E+GG P +V + A++D AV + S F + GQ C C+ + LV +G Sbjct: 235 SQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGA 294 Query: 353 H-DAFVKAFAEAMKKNLRVGN-GFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410 DA + A+ LRVG + G +I+ A E + K + KGA + Sbjct: 295 WGDALLARLV-AVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAM 353 Query: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470 + G P +L +V+ EE FGPL VI++ AI ANA GLA Sbjct: 354 TQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGL 412 Query: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSV-ECPFGGVKQSGLGR 514 S + + + G+V N+ L + PFGG+ SG R Sbjct: 413 LSDSRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHR 457 >3SZA-A nrPDB Length = 469 Score = 405 bits (1040), Expect = e-113, Method: Composition-based stats. Identities = 113/438 (25%), Positives = 190/438 (43%), Gaps = 20/438 (4%) Query: 98 ARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGE- 156 AV+ A AF R + R L L+ + + +L + A+ K A+ E Sbjct: 20 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 79 Query: 157 ILYSAFFLEWFSEEARRVYGDIIHTPAKDRRA---LVLKQPIGVAAVITPWNFPSAMITR 213 ++Y +E+ ++ D + + +P+GV VI WN+P + + Sbjct: 80 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 139 Query: 214 KVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICT 273 + A+AAG VV+KP+E + A LA + Q + +Y VI E Sbjct: 140 PMVGAIAAGNAVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTE-----LL 193 Query: 274 DPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKF 333 I +TGST GKI++ AA + V++ELGG +P V + ++D A KF Sbjct: 194 KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKF 253 Query: 334 RNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVE 393 N+GQTCV + L I + V+ +++K+ G ++ G +I+ + ++V Sbjct: 254 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF--YGEDAKKSRDYGRIISARHFQRVM 311 Query: 394 KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEE 453 + +G V GG + PT+L +V EE FGP+ P++ + E Sbjct: 312 GLI-----EGQKVAYGGT-GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 365 Query: 454 EAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLIS--SVECPFGGVKQSG 511 EAI N + LA Y +S + I ++ + G V N+ ++ PFGGV SG Sbjct: 366 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 425 Query: 512 LGREGSKYGIDEYLELKY 529 +G K + + + Sbjct: 426 MGSYHGKKSFETFSHRRS 443 >1AD3-A nrPDB Length = 452 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 109/438 (24%), Positives = 190/438 (43%), Gaps = 20/438 (4%) Query: 98 ARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGE- 156 V+ A EAF + S + R L ++ +N ++ + ++ GK ++ E Sbjct: 3 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 62 Query: 157 ILYSAFFLEWFSEEARRVYGDIIHTPAKDRRA---LVLKQPIGVAAVITPWNFPSAMITR 213 + + L+ +E D + + + +P+GV VI WN+P + + Sbjct: 63 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 122 Query: 214 KVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICT 273 + A+AAG V++KP+E + A LA L Q + +Y V+ E Sbjct: 123 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTE-----LL 176 Query: 274 DPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKF 333 I +TGST GKI++ AA + V++ELGG +P V ++D A KF Sbjct: 177 KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 236 Query: 334 RNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVE 393 N+GQTCV + L I + V+ +++K G ++ G +IN++ ++V+ Sbjct: 237 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF--YGEDAKQSRDYGRIINDRHFQRVK 294 Query: 394 KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEE 453 +++ V G + PT+L +V EE FGP+ P++ + E Sbjct: 295 GLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 348 Query: 454 EAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLIS--SVECPFGGVKQSG 511 EAI N + LA Y +S + I ++ + G V N+ ++ PFGGV SG Sbjct: 349 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 408 Query: 512 LGREGSKYGIDEYLELKY 529 +G K + + + Sbjct: 409 MGAYHGKKSFETFSHRRS 426 >4H7N-A nrPDB Length = 474 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 129/468 (27%), Positives = 202/468 (43%), Gaps = 27/468 (5%) Query: 73 AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMI 132 T V++P +G ++ R A A RW+E+ + R + L++W ++ Sbjct: 5 TKTIEVRNPRTGKFDYVIIPPPPRLLAQQCNRARRAQSRWQELGVEGRITTLQQWKQAIL 64 Query: 133 QNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLK 192 ++ L + ++G+ L EI ++ + A + + AL Sbjct: 65 SRREQLTEALVNDTGR-LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQS 123 Query: 193 -QPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP-FSALALAELASQAGIP 250 P + VI+PWNFP + AL AGC VVVKP+E P F A L Sbjct: 124 LVPYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLM--------- 174 Query: 251 SGVYNVIPCSRK------NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVS 304 N +P R E G + V + FTGS TG+ + AA Sbjct: 175 --ALNTVPELRDVLIFVEGGGETGANLIN--YVDFVCFTGSVATGREVAETAARRFIPAY 230 Query: 305 MELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM 364 +ELGG P IV +SAN++ A + + NTGQ+C+ + V + F A Sbjct: 231 LELGGKDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLI-AK 289 Query: 365 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFF-EPT 423 L++ E GP+I EK + + DAV KGA + GGK +LG ++ PT Sbjct: 290 AHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKVEELGGGWWCRPT 349 Query: 424 LLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAE 483 ++ NV M EETFGP+ PV+ F EEA+ +AN GL+ ++ + +VA Sbjct: 350 VMTNVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVAR 409 Query: 484 QLEVGMVGVNEGLISSV--ECPFGGVKQSGL-GREGSKYGIDEYLELK 528 QL G + +N+ ++++ E SGL G G+ +L + Sbjct: 410 QLNAGAISINDAALTAMMHEGEKNAFNFSGLGGSRVGAAGLKRFLRKQ 457 >4QGK-A nrPDB Length = 461 Score = 368 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 107/436 (24%), Positives = 189/436 (43%), Gaps = 26/436 (5%) Query: 102 VRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYS 160 VR +AF R + R L ++ + + D+ I A+ K + E++ Sbjct: 6 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 65 Query: 161 AFFLEWFSEEARRVYGDIIHTPAKDR------RALVLKQPIGVAAVITPWNFPSAMITRK 214 +++ E + P K A + QP+GV +I WN+P + + Sbjct: 66 LGEIDFMLENLPEW---VTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 122 Query: 215 VGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTD 274 + A+AAG V++KP+E + +A LA+L Q + +Y VI + E Sbjct: 123 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTE-----LLK 176 Query: 275 PLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFR 334 I +TG+T GKI++ AA + V++ELGG +P + ++D K+ Sbjct: 177 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 236 Query: 335 NTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEK 394 N GQTC+ + L + + + V E +K+ G +E +IN + +++ Sbjct: 237 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF--YGENIKESPDYERIINLRHFKRILS 294 Query: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454 + +G + GG+ + + PT+L +V EE FGP+ P++ +E Sbjct: 295 LL-----EGQKIAFGGETDE-ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDE 348 Query: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGL 512 AI N + LA Y +S + I R+ ++ G V N+ ++ PFGGV SG+ Sbjct: 349 AINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGM 408 Query: 513 GREGSKYGIDEYLELK 528 G K+ D + + Sbjct: 409 GAYHGKHSFDTFSHQR 424 >3V9H-A nrPDB Length = 566 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 104/452 (23%), Positives = 191/452 (42%), Gaps = 25/452 (5%) Query: 79 QDPAS-GAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNK 135 P + G + A+ AA A W +R+ + K +++ + Sbjct: 85 VSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRA 144 Query: 136 DDLARIITAESGKPLKEAHGEIL-YSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194 + LA+ + GK + +A + F + ++ A + G + + V + Sbjct: 145 EILAKTMV-GQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGL 203 Query: 195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVY 254 G A I+P+NF +A+ GA G V+ KP++ ++ A+ + +AG+P + Sbjct: 204 EGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNII 262 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV------KRVSMELG 308 +P + G+ + + + I+FTGS T K L A ++ R++ E G Sbjct: 263 QFVPA---DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECG 319 Query: 309 GLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL 368 G V SA+V+ V+G + S F GQ C + V + E + + Sbjct: 320 GKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSR-I 378 Query: 369 RVGNGFEE-GTTQGPLINEKAVEKVEKQVNDAVSKGA-TVVTGGKRHQLGKNFFEPTLLC 426 +VG+ E+ GT +I+ K+ +++K + A S + T++ GGK F EP ++ Sbjct: 379 KVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVE 438 Query: 427 NVTQDMLCTHEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAE 483 + EE FGP+ V + D +E + + ++ GL G +SQD + + Sbjct: 439 SKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATK 498 Query: 484 QLE--VGMVGVNEGLISSV--ECPFGGVKQSG 511 L G +N+ S+ + PFGG + SG Sbjct: 499 VLRNAAGNFYINDKSTGSIVGQQPFGGARASG 530 >4LGZ-A nrPDB Length = 563 Score = 363 bits (933), Expect = e-100, Method: Composition-based stats. Identities = 103/452 (22%), Positives = 195/452 (43%), Gaps = 25/452 (5%) Query: 79 QDPASGA-ALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNK 135 P + A + A+ AA A W +R+ + K +++ + Sbjct: 82 LSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRA 141 Query: 136 DDLARIITAESGKPLKEAHGEIL-YSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194 + LA+ + GK + +A + F + ++ A + G+ + V + Sbjct: 142 EVLAKTMV-GQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGL 200 Query: 195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVY 254 G A I+P+NF +A+ GA G V+ KP++ ++ A+ + +AG+P + Sbjct: 201 EGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNII 259 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV------KRVSMELG 308 +P + G+ + + + I+FTGS T K L A ++ R++ E G Sbjct: 260 QFVPA---DGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECG 316 Query: 309 GLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNL 368 G V SA+VD V+G + S F GQ C ++ V + + E + + Sbjct: 317 GKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSR-I 375 Query: 369 RVGNGFEE-GTTQGPLINEKAVEKVEKQVNDAVSKGA-TVVTGGKRHQLGKNFFEPTLLC 426 +VG+ E+ GT +I+ KA +++K + A S + +++ GG+ ++ + EP ++ Sbjct: 376 KVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIE 435 Query: 427 NVTQDMLCTHEETFGPLAPVIKFDTEE--EAIAIANA-ADVGLAGYFYSQDPAQIWRVAE 483 + EE FGP+ V + ++ E + + ++ GL G ++QD A + Sbjct: 436 SKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATR 495 Query: 484 QLE--VGMVGVNEGLISSV--ECPFGGVKQSG 511 L G +N+ SV + PFGG + SG Sbjct: 496 MLRNAAGNFYINDKSTGSVVGQQPFGGARASG 527 >5UCD-A nrPDB Length = 457 Score = 360 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 110/447 (24%), Positives = 192/447 (42%), Gaps = 25/447 (5%) Query: 94 GVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA 153 + + A F R L + +I NK+ L + + GKP Sbjct: 26 SPAKIDSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVV 85 Query: 154 -HGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRA----LVLKQPIGVAAVITPWNFPS 208 EI +++ + P+ D A V+++P GV +I P+N+P Sbjct: 86 DLAEIGAVLHEIDFALAHLDEWVAPV-SVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPV 144 Query: 209 AMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVG 268 + + A+ G T ++KP+E TP ++ + ++ ++A P V + + ++ Sbjct: 145 NLTLTPLIGAIIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVI-----QGGRDEN 199 Query: 269 EAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGA 328 + + P I FTGS GK+++ AA + V +ELGG P IV A++DQ V Sbjct: 200 SHLLSLP-FDFIFFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQL 258 Query: 329 MASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKA 388 M KF N+GQT + + V + DA ++ E +K L E + G L+ E+ Sbjct: 259 MFGKFINSGQTXIAPDYLYVHYSVKDALLERLVERVKTELP------EINSTGKLVTERQ 312 Query: 389 VEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIK 448 V+++ + ++G +V G + + K T++ V + EE FGP+ PV++ Sbjct: 313 VQRLVSLLEA--TQGQVLV--GSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLE 368 Query: 449 FDTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISS--VECPFG 505 FD+ AI N LA Y + +D + Q++ G VN ++ + PFG Sbjct: 369 FDSVRTAIDQVNKHHPKPLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFG 428 Query: 506 GVKQSGLGREGSKYGIDEYLELKYVCY 532 G+ SG+G + + K V Sbjct: 429 GIGASGMGEYHGHFSYLTFTHKKSVRI 455 >4OE4-A nrPDB Length = 580 Score = 349 bits (895), Expect = 2e-96, Method: Composition-based stats. Identities = 119/492 (24%), Positives = 204/492 (41%), Gaps = 35/492 (7%) Query: 51 LAGLSAALLRTDSFVGGRWL---PAAATFPVQDPAS-GAALGMVADCGVREARAAVRAAY 106 L ++ L + G + A FP +PA+ L V ++ AV+AA Sbjct: 50 LMKFKSSSLEVPLVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAK 109 Query: 107 EAFCRWREVSAKERSSLLRKWYNLM-IQNKDDLARIITAESGKPLKEAHGE-ILYSAFFL 164 +A W + +RS++ K +L+ + + D+ GK + +A + I + F Sbjct: 110 DAKKDWYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFF 169 Query: 165 EWFSEEARRVYGDIIHTPAKDRRALVLKQPI-GVAAVITPWNFPSAMITRKVGAALAAGC 223 ++ + A +Y A +P+ G ++P+NF +A+ +GA G Sbjct: 170 RYYVKYASDLYAQQPVESADGTWNKAEYRPLEGFVYAVSPFNF-TAIAANLIGAPALMGN 228 Query: 224 TVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFT 283 TVV KP++ S L + +AG+P GV N IP + +V + + D + FT Sbjct: 229 TVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPG---DPVQVTDQVLADKDFGALHFT 285 Query: 284 GSTTTGKILLHHAANSV--------KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRN 335 GST K L + V R+ E GG +V SAN+ AV + F Sbjct: 286 GSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEF 345 Query: 336 TGQTCVCSNQFLVQRGIHDAFV-KAFAEAMKKNLRVGN----GFEEGT---TQGPLINEK 387 GQ C +++ + + F+ F +N+ N G GP+I+E+ Sbjct: 346 QGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQ 405 Query: 388 AVEKVEKQVNDAVSKG-ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPV 446 + +K+ K + DA ++ GG+ + F PT++ D E FGP+ V Sbjct: 406 SFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTV 465 Query: 447 IKFDTEE--EAIAIA-NAADVGLAGYFYSQDPAQIWRVAEQLE--VGMVGVNEGLISSV- 500 ++ E E I N + L G +++D I E+L+ G +N+ +V Sbjct: 466 YEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVV 525 Query: 501 -ECPFGGVKQSG 511 + FGG + SG Sbjct: 526 SQQWFGGARMSG 537 >5NNO-A nrPDB Length = 546 Score = 323 bits (829), Expect = 1e-88, Method: Composition-based stats. Identities = 121/479 (25%), Positives = 207/479 (43%), Gaps = 42/479 (8%) Query: 83 SGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARII 142 S A G+ + + V EAF K+R +LR NL+ +N D+ + I Sbjct: 2 SMAPAGVPENTSLENIPVIVSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAI 61 Query: 143 TAESGKPLKEA--------HGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194 + + E E+ + ++ + + + + A + +P Sbjct: 62 HRDRRRHRDETVVMEILPLRNEVWHLIEHMDEYVKPVK----PTMEGAAALDDCELQYEP 117 Query: 195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVY 254 +GV VI WN+P +I + + ALAAG T V+KP+E P +A L +L + + S V Sbjct: 118 LGVVLVIGTWNYPLLLILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKY-VSSDVV 176 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFI 314 ++ V I +TGS +I++ AA + V++ELGG +P + Sbjct: 177 GIVNGGVSETTAV-----LKERFDHILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVV 231 Query: 315 VFDSA--NVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMK-----KN 367 V D+ N+ M K N GQT + + +V++ + V A AEA K K Sbjct: 232 VDDTCADNMKVVAERIMWGKIINAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKF 291 Query: 368 LRVGNG---------FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKN 418 L+V G F E + ++N +++ + + KG V GG+ + Sbjct: 292 LKVLKGELLVKQKQQFLEESDYPRIVNASHFQRLMEFM-----KGGKVAVGGEADE-ATL 345 Query: 419 FFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI 478 PT+L N+ EE FGP+ PV+ ++ E++ + I N+ + LA Y +S + I Sbjct: 346 TIAPTILTNIDPTHPVMQEEIFGPILPVLTYENEKDILKIINSREKPLALYVFSNNKRFI 405 Query: 479 WRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL 535 V + G V VN+ ++ + PFGGV +SG+G +Y + + + V G Sbjct: 406 RGVESRTSSGAVVVNDVVVHAGADGLPFGGVGRSGMGAYHGRYSFETFSHRRPVMRRGF 464 >4IDS-A nrPDB Length = 563 Score = 307 bits (787), Expect = 8e-84, Method: Composition-based stats. Identities = 120/502 (23%), Positives = 193/502 (38%), Gaps = 29/502 (5%) Query: 32 VPASGP----APGPAQLRCYAGRLAGLSAALLRTDSFVGGR-WLPAAATFPVQDPASGAA 86 VPA+ P AP + LA L+ + +GGR + V P AA Sbjct: 29 VPANEPVHDYAPKSPERTRLRTELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAA 88 Query: 87 -LGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQN-KDDLARIITA 144 LG + + +A AAV AA A W + ER+++ + +L+ ++ +A Sbjct: 89 RLGTLTNATHADAAAAVEAAMSAKSDWAALPFDERAAVFLRAADLLAGPWREKIAAATML 148 Query: 145 ESGKPLKEAHGE-ILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPI-GVAAVIT 202 K + +A + + F + AR++ + + +P+ G IT Sbjct: 149 GQSKSVYQAEIDAVCELIDFWRFNVAFARQIL-EQQPISGPGEWNRIDYRPLDGFVYAIT 207 Query: 203 PWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRK 262 P+NF S AL G TV+ KP+ +A +L AG+P GV N++ Sbjct: 208 PFNFTSIAGNLPTAPAL-MGNTVIWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTG--- 263 Query: 263 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVF 316 + V + DP ++ I FTGST T L ++ R + E GG + Sbjct: 264 DGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAH 323 Query: 317 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 376 SA D + F GQ C ++ + + A LR G+ + Sbjct: 324 ASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSVWQRMGDELL-AKAAELRYGDITDL 382 Query: 377 GTTQGPLINEKAVEKVEKQVNDAVSKGA-TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCT 435 G LI+++A K + A A TV GG+ F PT+L + Sbjct: 383 SNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEYDDSEGYFVRPTVLLSDDPTDESF 442 Query: 436 HEETFGPLAPVIKFDTE--EEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGMV 490 E FGPL V + E E+ + + + + L G + D + ++L G Sbjct: 443 VIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNF 502 Query: 491 GVNEGLISSV--ECPFGGVKQS 510 VN+ +V PFGG + S Sbjct: 503 YVNDKPTGAVVGRQPFGGARGS 524 >6D97-A nrPDB Length = 547 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 97/477 (20%), Positives = 172/477 (36%), Gaps = 51/477 (10%) Query: 62 DSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRA--------------AYE 107 +FV G W +A + DP +G VA+ E ++ + + A E Sbjct: 46 QNFVQGSWTASANWNWIVDPLNGDKFIKVAEVQGTEIKSFMESLSKCPKHGLHNPLKAPE 105 Query: 108 AFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWF 167 + + ++SAK L + D A++I S K ++A E+ S FLE F Sbjct: 106 RYLMYGDISAKAAHMLGQPTV------LDFFAKLIQRVSPKSYQQALAEVQVSQKFLENF 159 Query: 168 SEEARRVYGDIIHTPAK--DRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTV 225 + R P +R+ + P G A+ITP+NFP + ++ AL G Sbjct: 160 CGDQVRFLARSFAVPGNHLGQRSNGYRWPYGPVAIITPFNFPLEIPLLQLMGALYMGNKP 219 Query: 226 VVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGS 285 V+K + L G+P+ + I V + + FTGS Sbjct: 220 VLKVDSKVSIVMEQMIRLLHDCGLPAEDMDFINS----DGAVMNKLLLEANPKMTLFTGS 275 Query: 286 TTTGKILLHHAANSVKRVSMELGGLAPFIVFDSA-NVDQAVAGAMASKFRNTGQTCVCSN 344 + + L AA+ RV +E G I+ VD + +GQ C + Sbjct: 276 SRVAEKL---AADLKGRVKLEDAGFDWKILGPDVQEVDYVAWVCDQDAYACSGQKCSAQS 332 Query: 345 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 404 + + + + + + + ++ E T GP++ +E N +G+ Sbjct: 333 VLFMHKNWSSSGLLEKMKKLSERRKL-----EDLTIGPVLTVTTEAMIEHMNNLLKIRGS 387 Query: 405 TVVTGGKR---HQLGKNF--FEPTLLCNVTQD------MLCTHEETFGPLAPVIKF--DT 451 V+ GG+ H + K + +PT + ++ +E FGP V ++ D Sbjct: 388 KVLFGGEPLANHSIPKIYGAMKPTAVFVPLEEILKSGNFELVTKEIFGPFQVVTEYSEDQ 447 Query: 452 EEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVG--VNEGLISSVE-CPFG 505 E + + L S DP + V + G + + + FG Sbjct: 448 LELVLEACERMNAHLTAAIVSNDPLFLQDVLGRSVNGTTYAGIRARTTGAPQNHWFG 504 >2Y53-A nrPDB Length = 534 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 104/465 (22%), Positives = 171/465 (36%), Gaps = 42/465 (9%) Query: 55 SAALLRTDSFVGGRWLPA-AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWR 113 S + V G+W+ A + DP +G AL V+ G+ ARA A + R Sbjct: 2 SHMTELLKNHVAGQWIAGTGAGITLTDPVTGVALVRVSSEGLDLARAFSFAREDGGAALR 61 Query: 114 EVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 ++ +R++ L L+ + D I TA SG ++ +I F L ++++ Sbjct: 62 ALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTTRNDSAVDIDGGIFTLSYYAKLGAS 121 Query: 174 VY---------GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCT 224 + + + VL GVA I +NFPS + K AL +G Sbjct: 122 LGEVHALRDGSAESLSKDRSFSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALLSGVP 181 Query: 225 VVVKPAEDTPFSALALAELASQAG-IPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFT 283 V+VKPA T + + AG +P G ++I S + +SFT Sbjct: 182 VIVKPATATAWLTQRMVADVVDAGILPPGALSIICGSSAG------LLDQIRSFDVVSFT 235 Query: 284 GSTTTGKILLHHAA--NSVKRVSMELGGLAPFIVFDSAN-----VDQAVAGAMASKFRNT 336 GS T L H A R++++ L I+ A D + + + Sbjct: 236 GSADTAATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKS 295 Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQV 396 GQ C + V + ++A + K + VGN + G L++ + E V + Sbjct: 296 GQKCTAIRRAFVPEAALEPVLEALKAKLAK-ITVGNPRNDAVRMGSLVSREQYENVLAGI 354 Query: 397 NDAVSKGATVVTGGKRHQL-------GKNFFEPTLLCNVTQDMLCTHE-ETFGPLAPVIK 448 + A + L + N + H+ E FGP+A V Sbjct: 355 AALREE-AVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAP 413 Query: 449 FD--------TEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485 + E A+A+A L YS D A + R+A +L Sbjct: 414 YRVTTDTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALEL 458 >3V4C-A nrPDB Length = 528 Score = 244 bits (623), Expect = 8e-65, Method: Composition-based stats. Identities = 121/471 (25%), Positives = 179/471 (38%), Gaps = 55/471 (11%) Query: 60 RTDSFVGGRWLPAAATF---PVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116 + V G WL A TF P PA A+G V A AA EAF + S Sbjct: 29 KGKHLVAGEWLDGAGTFASAPAHGPAHDFAVGTV-----ELVNRACEAAEEAFWTYGYSS 83 Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYG 176 KER++ LR + + + + I + E+G P +GE + L F++ + G Sbjct: 84 RKERAAFLRAIADEIEARAEAITEIGSQETGLPEARLNGERGRTTGQLRLFADHIEK--G 141 Query: 177 DII----------HTPAKDRRALVLKQPIGVAAVITPWNFPSA--MITRKVGAALAAGCT 224 D + PA + ++++P+G AV NFP A AALAAGC Sbjct: 142 DYLDRRVDAAMPERQPAPRQEIRLVQRPVGPVAVFGASNFPLAFSTAGGDTAAALAAGCP 201 Query: 225 VVVKPAEDTPFSALALAELASQA----GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 280 VVVK P + +AE A G+ GV+++I +++VG A+ P + + Sbjct: 202 VVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQG---GSRDVGHALVQHPHIKAV 258 Query: 281 SFTGSTTTGKILLHHAANSVKRVSM--ELGGLAPFIVFDSANVDQAV---AGAMASKFRN 335 FTGS G+ L A + + ELG + P + A +A G S Sbjct: 259 GFTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEALKARAETLGQGWAGSLTMG 318 Query: 336 TGQTCVCSNQFLVQRGI-HDAFVKAFAEAMKK---NLRVGNGFEEGTTQGPLINEKAVEK 391 GQ C +V G D F A EA+ K + +G + G + Sbjct: 319 AGQFCTNPGIAVVIEGADADRFTTAAVEALAKVAPQTMLTDGIAKAYRDG---------Q 369 Query: 392 VEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDT 451 +AV + G+ N FE T + EE FGPL V++ + Sbjct: 370 ARFATRNAVKPLLATESSGR--DASPNLFETTGAQFLADHA--LGEEVFGPLGLVVRVGS 425 Query: 452 EEEAIAIANAADVGLAGYFY--SQDPAQIWRVAEQLE--VGMVGVNEGLIS 498 E +A L + + D R+ LE G V VN Sbjct: 426 PAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVLVNGFPTG 476 >5DBV-A nrPDB Length = 445 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 80/425 (18%), Positives = 163/425 (38%), Gaps = 42/425 (9%) Query: 96 REARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG 155 + A+ AA EA +++S +R ++ I++ + LAR+ E+G G Sbjct: 16 DDMNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETGM------G 69 Query: 156 EILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQ--PIGVAAVITPWNFPSAMITR 213 + + + +E+ DI T R L L + P GV ITP PS I Sbjct: 70 NVGHKILKHQLVAEKTPGTE-DITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETIIC 128 Query: 214 KVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGV-YNVIPCSRKNAKEVGEAIC 272 LA G TVV P ++ +L ++A + +G N+ RK + + + Sbjct: 129 NTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKIMM 188 Query: 273 TDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASK 332 + + I+ TG G ++ S KR G P +V ++A++ +A + Sbjct: 189 SHQDIPLIAATG----GPGVVTAVLQSGKRGIGAGAGNPPVLVDETADIRKAAEDIINGC 244 Query: 333 FRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKV 392 + + + + I + + + E+G I ++ EK+ Sbjct: 245 TFDNNLPAIAEKEVVAIDAIANELMNYMVK------------EQGCYA---ITKEQQEKL 289 Query: 393 EKQV-------NDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAP 445 V + V K A + G + N ++ ++ EE P+ Sbjct: 290 TNLVITPKGLNRNCVGKDARTLLGMIGIDVPSNI--RCIIFEGEKEHPLISEELMMPILG 347 Query: 446 VIKFDTEEEAIAIANAADVGL--AGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECP 503 +++ + ++A+ A + G + + +S++ +I A+ ++ ++ N +++ Sbjct: 348 IVRAKSFDDAVEKAVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVKNAPSYAAIG-- 405 Query: 504 FGGVK 508 FGG Sbjct: 406 FGGEG 410 >1EZ0-A nrPDB Length = 510 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 98/450 (21%), Positives = 172/450 (38%), Gaps = 40/450 (8%) Query: 74 ATFPVQDPASGAAL-GMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMI 132 F + +G AL E A AA + +R ++ +R+SLLR + + Sbjct: 7 NVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVARDFRRLNNSKRASLLRTIASELE 66 Query: 133 QNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE--EARRVYGDIIHTPAKDRRAL- 189 DD+ E+ P GEI +A L F++ + + I+ TP R L Sbjct: 67 ARSDDIIARAHLETALPEVRLTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRAPLP 126 Query: 190 ---VLKQ--PIGVAAVITPWNFPSAMIT--RKVGAALAAGCTVVVKPAEDTPFSALALAE 242 + +Q +G AV NFP A +ALAAGC V+VK P ++ +AE Sbjct: 127 KPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAAGCPVIVKGHTAHPGTSQIVAE 186 Query: 243 LASQA----GIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298 QA +P ++ ++ ++ + +G+A+ + P + + FTGS G+ L + A Sbjct: 187 CIEQALKQEQLPQAIFTLLQGNQ---RALGQALVSHPEIKAVGFTGSVGGGRALFNLAHE 243 Query: 299 SVKRV--SMELGGLAPFIVFDSANVDQA--VAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354 + + ELG + P +F SA +A +AS GQ C ++ Sbjct: 244 RPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCGQFCTKPGVVF---ALNT 300 Query: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414 +AF E + +R T P I + +V V+ G V Sbjct: 301 PETQAFIETAQSLIR---QQSPSTLLTPGIRDSYQSQV---VSRGSDDGIDVTF---SQA 351 Query: 415 LGKNFFEPTLLCNVTQ--DMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 472 + + EE FGP + ++ + + ++++ L ++ Sbjct: 352 ESPCVASALFVTSSENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGSLTATIHA 411 Query: 473 Q--DPAQIWRVAEQLE--VGMVGVNEGLIS 498 D Q+ ++ +LE G + N Sbjct: 412 TEEDYPQVSQLIPRLEEIAGRLVFNGWPTG 441 >5UJU-A nrPDB Length = 576 Score = 175 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 97/477 (20%), Positives = 162/477 (33%), Gaps = 60/477 (12%) Query: 73 AATFPVQDPASGAALG--MVADCGVREA-------RAAVRAAYEAFCRWREVSAKERSSL 123 TF + PASG +G + A + AA A WRE + Sbjct: 63 GKTFELDQPASGETVGAERSPYGVALDIRYPKSTPDALIAAAAAAQRTWREAGPSAWIGV 122 Query: 124 LRKWYNLMIQNKDDLAR----------IITAESGKPLKE--AHGEILYSAFFLEWFSEEA 171 + + + ++A ++ ++G P + A + Y+ L +A Sbjct: 123 SLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWDQLRRIPADA 182 Query: 172 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 231 + P ++ + P G V+ FP+ + A LA G TV+VKP Sbjct: 183 HWEKPQGKNPPLAMQKRYTI-VPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHP 241 Query: 232 DTPFSALALAEL----ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287 + +AG V ++ + N + + + P + I FTGST Sbjct: 242 GAILPLAITVRIARDVLREAGFDPNVVTLL-ATEPNDGALVQDLALRPEIKLIDFTGSTQ 300 Query: 288 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347 G L HA + +V E G+ ++ + ++ A S +GQ C Sbjct: 301 NGTWLERHAHQA--QVYTEKAGVNQIVIDSTDDLKAAAKNIAFSLALYSGQMCTAPQNIY 358 Query: 348 VQR-GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATV 406 V R GI A A + + + + G + T P ++VE + ND V+ Sbjct: 359 VPRDGIRTADGHASFDEVAQAI---AGAVQKLTGDP---ARSVELIGAIQNDGVTARIDA 412 Query: 407 VTGGKRHQLGKNFFE-----------PTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEA 455 R L + P +L D +E FGP++ VI D+ ++ Sbjct: 413 ARAVGRVLLDSQTLQHPAFPDARVRTPLVLQLDVADREKFTQEWFGPISFVIATDSTAQS 472 Query: 456 IAIANAA---DVGLAGYFYS--QD-PAQIWRVAEQLEV-------GMVGVNEGLISS 499 + +A L YS D A + V G V VN+ S Sbjct: 473 LDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGVALSINLTGGVFVNQSAAFS 529 >5J7I-A nrPDB Length = 488 Score = 171 bits (433), Expect = 9e-43, Method: Composition-based stats. Identities = 90/448 (20%), Positives = 152/448 (33%), Gaps = 60/448 (13%) Query: 85 AALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITA 144 + L + ++E R + A A +++ E ++ N + LA + Sbjct: 23 SMLRDIDLQSIQEVRNYLEEAKAAQKILEKMTQSEIDKIVESMANAAREEAGRLAAMAVE 82 Query: 145 ESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDI----IHTPAKDRRALVLKQPIGVAAV 200 E+G G + + + + D+ I ++ R + QP+G+ A Sbjct: 83 ETG------FGNVEDKTLKNLFAANDVYNSIKDVKTVGIIRRDEENRVWEIAQPVGIVAG 136 Query: 201 ITPWNFPSAMITRKVGAALAAGCTVVVKPAE----DTPFSALALAELASQAGIPSGVYNV 256 I P P++ + K A+ A +V P T +A + E A +AG P G + Sbjct: 137 IIPSTNPTSTVIFKALIAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKG---L 193 Query: 257 IPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG-GLAPFIV 315 I C + + L I TG L AA S + + +G G P + Sbjct: 194 ISCITQPTMAATNELMKHKLTDVILATGGPG-----LVKAAYSSGKPAYGVGPGNVPVYI 248 Query: 316 FDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFE 375 +SAN+ +AV + SK + G C LV I + V + L Sbjct: 249 HESANIAKAVQLIIQSKTFDYGTICASEQALLVDESIKEKVVAELKQQGAYFL------- 301 Query: 376 EGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH----QLGKNFFEPTLLCNVTQD 431 NE+ +KV + S A +V GK ++ + V ++ Sbjct: 302 ---------NEEEKQKVASIIMVNGSLNAKIV--GKAPQVIAEMAGIEIPSDVKLLVAEE 350 Query: 432 MLCTHEETF-----GPLAPVIKFDTEEEAIAIANAA--DVGL--AGYFYSQDPAQIWRVA 482 E F P+ EEA +A GL +++D I Sbjct: 351 TEVGKEYPFSIEKLSPILAFYIVKGMEEASELAQKLLEVGGLGHTVGIHAEDEKVIEAYT 410 Query: 483 EQLEVGMVGVNEGLISSVECPFGGVKQS 510 G + VN G FGG+ + Sbjct: 411 IDKPAGRIVVNAGTT------FGGIGAT 432 >3K9D-A nrPDB Length = 464 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 75/433 (17%), Positives = 162/433 (37%), Gaps = 47/433 (10%) Query: 94 GVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA 153 ++E R + +A +A +S ++ ++++ + ++ LA++ E+G + + Sbjct: 10 SIQEVRNLIESANKAQKELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGIWQD 69 Query: 154 HGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITR 213 ++ + F + + + + +++ + + P+GV A + P P++ + Sbjct: 70 K--VIKNVFASKHVYNYIKDMKTIGMLKEDNEKKVMEVAVPLGVVAGLIPSTNPTSTVIY 127 Query: 214 KVGAALAAGCTVVVKPAEDTPFSAL----ALAELASQAGIPSGVYNVIPCSRKNAKEVGE 269 K ++ AG ++V P + + L ++E A +AG P G I C + + Sbjct: 128 KTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGA---ISCMTVPTIQGTD 184 Query: 270 AICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG-GLAPFIVFDSANVDQAVAGA 328 + + I TG + + AA S ++ +G G P + SAN+ +AV Sbjct: 185 QLMKHKDTAVILATGGSA-----MVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHI 239 Query: 329 MASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM------KKNLRVGN-GFEEGTTQG 381 + SK + G C +V+R +A + F + + +++G + Sbjct: 240 LDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMN 299 Query: 382 PLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFG 441 P I K+V+ + V A V+ + V + E Sbjct: 300 PAIVGKSVQHIANLAGLTVPADARVLIAEE--------------TKVGAKIP-YSREKLA 344 Query: 442 PLAPVIKFDTEEEAIAIANAADVGLAGY----FYSQDPAQIWRVAEQLEVGMVGVNEGLI 497 P+ +T +EA ++ +S+D I A + V + VN Sbjct: 345 PILAFYTAETWQEACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNTPGA 404 Query: 498 SSVECPFGGVKQS 510 GG+ + Sbjct: 405 L------GGIGAT 411 >3MY7-A nrPDB Length = 452 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 78/431 (18%), Positives = 158/431 (36%), Gaps = 34/431 (7%) Query: 90 VADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKP 149 + + E A + +A + S ++ + R Q + LA+ ESG Sbjct: 1 MPVTNMAELDAMIARVKKAQEEFATYSQEQVDKIFRAASLAANQARIPLAQQAVEESGMG 60 Query: 150 LKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSA 209 + E + A + + + G I + + + +P+G+ I P P++ Sbjct: 61 IVEDKVIKNHFASEFIYNKYKDEQTCG--ILEEDDNLGTMTIAEPVGIICGIVPTTNPTS 118 Query: 210 MITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVY-NVIPCSRKNAKEVG 268 K +L ++ P S A+L A + +G ++I + + E+ Sbjct: 119 TAIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSVELS 178 Query: 269 EAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG-GLAPFIVFDSANVDQAVAG 327 A+ ++ I TG + AA S + ++ +G G P ++ ++A++ +AVA Sbjct: 179 NALMKHDDIALILATGGPG-----MVKAAYSSGKPAIGVGAGNVPVVIDETADIKRAVAS 233 Query: 328 AMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEK 387 + SK + G C +V ++D + FA L + + + LI+ Sbjct: 234 VLMSKTFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVLSKTD--ADKVRKVLLIDGA 291 Query: 388 AVEKVEKQVNDAVSK--GATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAP 445 K+ Q A+++ G V K L V+ D HE+ P Sbjct: 292 LNAKIVGQPATAIAEMAGVKVPADTKVLIGEG-------LGKVSYDDAFAHEKL-SPTLG 343 Query: 446 VIKFDTEEEAIAIANAAD----VGLAGYFYSQ---DPAQIWRVAEQLEVGMVGVNEGLIS 498 + + D E+A+A A +G Y+ + +I ++++ + +N Sbjct: 344 MFRADNFEDAVAQAVTMVEIGGIGHTSGLYTNQDVNADRIRYFGDKMKTARILINIPTT- 402 Query: 499 SVECPFGGVKQ 509 GG+ Sbjct: 403 -----HGGIGD 408 >5JFN-A nrPDB Length = 524 Score = 146 bits (368), Expect = 3e-35, Method: Composition-based stats. Identities = 71/415 (17%), Positives = 144/415 (34%), Gaps = 55/415 (13%) Query: 116 SAKERSSLLRKWYNLMIQN--KDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARR 173 S +R+ ++ ++++ + ++R+ E+G G + E+ Sbjct: 112 SMSDRARFVQGIRDVILNQDTLEKMSRMAVEETGM------GNYEHKLIKNRLAGEKTPG 165 Query: 174 VYGDIIHT-PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAED 232 + + LV P GV ITP P+ I LAAG +VV P Sbjct: 166 IEDLTTDAFSGDNGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPR 225 Query: 233 TPFSALALAELASQAGIPSGVY-NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 291 +L L L +Q G N++ K + E A+ P V + TG G Sbjct: 226 ARQVSLLLVRLINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATG----GPA 281 Query: 292 LLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG 351 ++ ++ K+ G P +V ++AN+++A + + V + + Sbjct: 282 IVKAVLSTGKKAIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIAVAQ 341 Query: 352 IHDAFVKAFAEAMKKNLRVGNG--------FEEGTTQGPLIN--EKAVEKVEKQVNDAVS 401 I D + + ++ + GP K+ + Q+ +V Sbjct: 342 IADYLIFNLKKNGAYEIK--DPAVLQQLQDLVLTAKGGPQTKCVGKSAVWLLSQIGISVD 399 Query: 402 KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA-- 459 + +L V ++ EE P+ P+++ +T ++AI +A Sbjct: 400 ASIKI-----------------ILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIE 442 Query: 460 ----NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQS 510 N +S D ++ ++A+ ++ + N + + GG S Sbjct: 443 VEHDNRH----TAIMHSTDVRKLTKMAKLIQTTIFVKNGPSYAGLGA--GGEGYS 491 >1O20-A nrPDB Length = 427 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 75/470 (15%), Positives = 144/470 (30%), Gaps = 95/470 (20%) Query: 96 REARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG 155 A + EA+ R + +E++ ++K + + + ++ + K + Sbjct: 15 ELLEKA-KKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGVK 73 Query: 156 E------------ILYSAFFLEWFSEEARRVYGDIIHT--PAKDRRALVLKQPIGVAAVI 201 E I E V G++I + R ++ PIG +I Sbjct: 74 ESLVDRLALNDKRIDEMIKACETVIGLKDPV-GEVIDSWVREDGLRIARVRVPIGPIGII 132 Query: 202 ---TPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQA----GIPSGVY 254 P + AL +G T++++ D S A+ +A IP Sbjct: 133 YESRP-----NVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSV 187 Query: 255 NVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELG-GLAPF 313 I + V E I +S + G L+ ++ +E G G Sbjct: 188 EFI--ENTDRSLVLEMIRLREYLSLV----IPRGGYGLISFVRDNATVPVLETGVGNCHI 241 Query: 314 IVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNG 373 V +SA++ +AV + +K + G TC + + LV I F+ E ++K+ G Sbjct: 242 FVDESADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELRKHGVEVRG 300 Query: 374 FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDML 433 E+ P + + PT ++ Sbjct: 301 CEKTREIVPDVVPATEDDW-----------------------------PTEYLDL----- 326 Query: 434 CTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVN 493 + + +EAI G + +++ + + +++ V VN Sbjct: 327 ---------IIAIKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVN 377 Query: 494 EGLISSVECPFGGVKQSGLGREG----------SKYGIDEYLELKYVCYG 533 + F G G E G+ E K+V G Sbjct: 378 ASTRFTDGGQF------GFGAEIGISTQRFHARGPVGLRELTTYKFVVLG 421 >4GHK-A nrPDB Length = 444 Score = 95.3 bits (236), Expect = 6e-20, Method: Composition-based stats. Identities = 85/446 (19%), Positives = 139/446 (31%), Gaps = 93/446 (20%) Query: 122 SLLRKWYNLMIQNKDDLARIITAESG----KPLKEAHGE--------ILYSAFFLEWFSE 169 + L + ++ L + K L A + + L + Sbjct: 52 AALEAVARAIERDAGALKAANARDVARAKDKGLDAAFVDRLTLSDKALKTMVEGLRQVAT 111 Query: 170 EARRVYGDI--IHTPAKDRRALVLKQPIGVAAVI---TPWNFPSAMITRKVGAALAAGCT 224 + G++ + + ++ P+GV +I P + L +G Sbjct: 112 LPDPI-GEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRP-----NVTIDAAALCLKSGNA 165 Query: 225 VVVKPAEDTPFSALALAEL----ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 280 +++ + S ALA+L ++AG+P V+ + VG I V I Sbjct: 166 TILRGGSEALESNTALAKLIGEGLAEAGLPQDTVQVV--ETADRAAVGRLITMTEYVDVI 223 Query: 281 SFTGSTTTGKILLHHAANSVK-RVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 339 GK L+ N + + L G+ V D A+V +A+ +K G T Sbjct: 224 V----PRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASVTKALTVCDNAKTHRYG-T 278 Query: 340 CVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDA 399 C LV RGI A + G L EK VE A Sbjct: 279 CNTMETLLVARGIAPAVLSPL--------------------GRLYREKGVELRVDADARA 318 Query: 400 VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 459 V + A V P L + T + E P+ + D + AI Sbjct: 319 VLEAAGV--------------GP--LVDATDED--WRTEYLAPVLAIKIVDGIDAAIEHI 360 Query: 460 NAADVGL--AGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREG- 516 N + G ++D + R +++ V VN + F GLG E Sbjct: 361 N--EYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEF------GLGAEIG 412 Query: 517 ---------SKYGIDEYLELKYVCYG 533 G++ LKYV G Sbjct: 413 ISNDKLHARGPVGLEGLTSLKYVVLG 438 >4JBE-A nrPDB Length = 445 Score = 77.2 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 67/447 (14%), Positives = 128/447 (28%), Gaps = 85/447 (19%) Query: 91 ADCGVREARAAVR----AAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAES 146 ++ E AV AA A + L + ++ ++D + + Sbjct: 30 SNAMTNEVAKAVEECARAAKSAAPSLSGAPDTAIDAALESMADRLLAHRDAVLAANAEDI 89 Query: 147 GK--------------PLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLK 192 K + E+ + A L + + T R + + Sbjct: 90 AKAEAGGMSAGLLDRLTITESR--LTDMADQLRLLAGAPHPQRTVELSTLDGGLRLVERR 147 Query: 193 QPIGVAAVITPWNFPS--AMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL-----AS 245 +P+GV N+ + + + + V++ SA L E+ + Sbjct: 148 RPVGVIGA----NYEARPNVTVDVASQLVKSRNAGVLRTGSAALKSAQRLLEVVIRPALT 203 Query: 246 QAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSM 305 +GI + V ++P R + G + LV + GS + + L AA R Sbjct: 204 DSGIDANVVQLVP--RPEREAAGALVRLPDLVPLVILRGSGESTRALALEAAQHGVRTLA 261 Query: 306 ELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMK 365 G V + A+ D V + + G C N L+ +++ F +EA+ Sbjct: 262 HADGGGVLYVDEKADRD-TVRSLVVNSLDRLG-VCNRLNLLLIHDAVYEEFWPVVSEALA 319 Query: 366 KNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLL 425 + + P + E +A A V Sbjct: 320 ERGV-------SPSLPPYDHPIGYEWALDSEREATVTVARV------------------- 353 Query: 426 CNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485 V + + +EET GLA ++D + Sbjct: 354 DGVAEAVRIANEET------------------------SGLAAGIATEDARAAEEFFDGY 389 Query: 486 EVGMVGVNEGLISSVECPFGGVKQSGL 512 + V N GV ++G+ Sbjct: 390 QGTGVFWNAPTRLLDGFKLLGVPETGI 416 >1VLU-A nrPDB Length = 468 Score = 76.0 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 57/444 (12%), Positives = 139/444 (31%), Gaps = 72/444 (16%) Query: 99 RAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR------IITAESG----- 147 + + A +A + +S + RS +L K ++ + N + + E+G Sbjct: 17 QQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSL 76 Query: 148 -KPLKEAHGE-ILYSAFFLEWFSEEARRVYGDIIHTPAKDR-RALVLKQPIGVAAVITPW 204 K L G+ ++ +E V + D + P+GV VI + Sbjct: 77 LKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVI--F 134 Query: 205 NFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELAS--------QAGIPSGVYNV 256 +I ++ +G ++K +++ + +A++ + + G+P G + Sbjct: 135 ESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQL 194 Query: 257 IPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVF 316 I + ++V + + D + + GS + + + V G+ + Sbjct: 195 I----ETRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDT---TKIPVLGHADGICSIYLD 247 Query: 317 DSANVDQAVAGAMASKFRN-TGQTCVCSNQFLVQR--GIHDAFVKAFAEAMKKNLRVGNG 373 + A++ +A ++ +K G C L+ ++ ++ + + Sbjct: 248 EDADLIKAKRISLDAKTNYPAG--CNAMETLLINPKFSKWWEVLENLT--LEGGVTIHAT 303 Query: 374 FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDML 433 + T +K+ + + V + K F ++ Sbjct: 304 KDLKTAY--------FDKLNELGKLTEAIQCKTVDADEEQDFDKEFLS----LDLAAKF- 350 Query: 434 CTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVN 493 + E AI N +++ A + + ++ V N Sbjct: 351 ---------------VTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWN 395 Query: 494 EGLISSVECPFGGVKQSGLGREGS 517 + G + G G E Sbjct: 396 ASTRFAD-----GFRY-GFGAEVG 413 >2H5G-A nrPDB Length = 463 Score = 73.0 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 75/469 (15%), Positives = 142/469 (30%), Gaps = 98/469 (20%) Query: 98 ARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEI 157 A + ++R+ ++ +L+ +D++ + K L+EA G + Sbjct: 31 VEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLA----NKKDLEEAEGRL 86 Query: 158 L---------------YSAFFLEWFSEEARRVYGDIIH--TPAKDRRALVLKQPIGVAAV 200 A L + ++ G ++ AK+ + PIGV V Sbjct: 87 AAPLLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLV 146 Query: 201 ITPWNF---PSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVI 257 I F P + + A+A+G +++K ++ S L L +A GV + Sbjct: 147 I----FESRPDCLP-QVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAV 201 Query: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 317 +EV + D ++ I GS+ + + AA + V G+ V Sbjct: 202 QLVNTR-EEVEDLCRLDKMIDLIIPRGSSQLVRDI-QKAAKGI-PVMGHSEGICHMYVDS 258 Query: 318 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRG-----IHDAFVKAF-AEAMKKNLRVG 371 A+VD+ SK C L+ R + D + E +K + G Sbjct: 259 EASVDKVTRLVRDSKCEYPA-ACNALETLLIHRDLLRTPLFDQIIDMLRVEQVK--IHAG 315 Query: 372 NGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQD 431 F T P +V ++ + Sbjct: 316 PKFASYLTFSP-----------SEVKSLRTEYGDLE------------------------ 340 Query: 432 MLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY--FYSQDPAQIWRVAEQLEVGM 489 + D ++AI G + ++D + ++ Sbjct: 341 ------------LCIEVVDNVQDAIDHI--HKYGSSHTDVIVTEDENTAEFFLQHVDSAC 386 Query: 490 VGVNEGLISSVECPFG-----GVKQSGLGREGSKYGIDEYLELKYVCYG 533 V N S FG G+ S + G++ L K++ G Sbjct: 387 VFWNASTRFSDGYRFGLGAEVGISTSRIHAR-GPVGLEGLLTTKWLLRG 434 >4YIF-A nrPDB Length = 164 Score = 33.3 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 17/63 (26%), Positives = 26/63 (41%), Gaps = 11/63 (17%) Query: 81 PASG-AALGMVADCGVREARAAVRAAYEAFCRW-----REVSAKERSSLLRKWYNLMIQN 134 P G L V++ G V+AA A W ++ ER +LR +LM+ Sbjct: 105 PIDGRQVLVSVSESGAEL----VKAARRARQEWLAERLATLNRSER-DILRSAADLMLAL 159 Query: 135 KDD 137 D+ Sbjct: 160 VDE 162 >6MFV-A nrPDB Length = 653 Score = 32.1 bits (72), Expect = 0.63, Method: Composition-based stats. Identities = 21/156 (13%), Positives = 56/156 (35%), Gaps = 29/156 (18%) Query: 347 LVQRGIHDAFVKAFAEAMKKNLR-------VGNGFEEGT----------TQGPLINEKAV 389 ++ ++ + + EA+K L+ +G+ +EG G EK + Sbjct: 445 YAEKTKYEYYKENSREALKSALKELEIIRKIGDPEKEGLVLLHVGDIYLHMG--NYEKGI 502 Query: 390 EKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF 449 ++ + A + G + +L K +++ L ++ F + + Sbjct: 503 SYYQEALKMAKAYGIKFLEHISYMELAKGYYQLKLYEKASEYSEKAAN-YF---LMIRNY 558 Query: 450 DTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485 +A+A G Y +++ + + A+++ Sbjct: 559 RRATDAMA------YGSVSYIATKNLEKAEKFAKEM 588 >2WVR-A nrPDB Length = 209 Score = 32.1 bits (72), Expect = 0.63, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 30/76 (39%), Gaps = 15/76 (19%) Query: 112 WREVSAKERSSLLRKWYN------LMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLE 165 W+EV+ K R +L + Q +++AR+ E+ A ++ Sbjct: 99 WKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENK---------ELAEVAEHVQ 149 Query: 166 WFSEEARRVYGDIIHT 181 + +E R+ G+ + Sbjct: 150 YMAELIERLNGEPLDN 165 >5A0V-A nrPDB Length = 561 Score = 31.8 bits (71), Expect = 0.86, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 37/116 (31%), Gaps = 16/116 (13%) Query: 386 EKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNF--------FEPTLLCNVTQDMLCTHE 437 V ++++ ++ A G V G+ P L+ +V Sbjct: 242 ASHVHRIQQILDAAHEYGRRVAFVGRSMVRNMGIARDLGYLKVPPGLVVDVKTLDDLPDS 301 Query: 438 ETF-------G-PLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485 E G P+A + + + I I N V LA + ++RV L Sbjct: 302 EVVLVCTGSQGEPMAALSRMANRDHQIRIVNGDTVILASSLIPGNENAVYRVINGL 357 >4X6G-A nrPDB Length = 316 Score = 31.4 bits (70), Expect = 0.98, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 30/93 (32%), Gaps = 3/93 (3%) Query: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409 + + D E K +R+ EG + + + + ++ A + Sbjct: 43 KKLEDELGVLIFERSKSAVRLT-PVGEGIVAQAQKVLEQAQGIRELAQAGKNQLAAPLKV 101 Query: 410 GKRHQLGKNFFEPTL--LCNVTQDMLCTHEETF 440 G + +G F + L V M EE F Sbjct: 102 GAIYTIGPYLFPHLIPQLHRVAPQMPLYIEENF 134 >3OD1-A nrPDB Length = 400 Score = 31.4 bits (70), Expect = 0.98, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 32/86 (37%), Gaps = 13/86 (15%) Query: 162 FFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAA 221 + +EE D+I TP L + +GV + I K+ Sbjct: 29 NICDQMTEEINLWGYDMIETPT-----LEYYETVGVVSAI------LDQQLFKLLD--QQ 75 Query: 222 GCTVVVKPAEDTPFSALALAELASQA 247 G T+V++P P + L + L +A Sbjct: 76 GNTLVLRPDMTAPIARLVASSLKDRA 101 >3WHK-A nrPDB Length = 270 Score = 31.4 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 27/81 (33%), Gaps = 8/81 (9%) Query: 242 ELASQAGI--PSGVYNVIPCSRKNAKEVGEAICTDP-LVSKISFTGSTTTGKILLHHAAN 298 EL + GI P GV ++ K + + I GS K + A Sbjct: 41 ELFEEVGIDPPKGV--LLYGPPGCGKTLMAKAIAHEVNATFIRVVGSELVRKYIGEGA-- 96 Query: 299 SVKRVSMELGG-LAPFIVFDS 318 + EL AP I+F Sbjct: 97 RLVHELFELAKEKAPTIIFID 117 >6AHD-9 nrPDB Length = 800 Score = 31.4 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 26/78 (33%), Gaps = 17/78 (21%) Query: 81 PASGAALGMVADCGVREARAAVRAAYEAF---------------CRWREVSAK--ERSSL 123 P + + +A E R + AA E W + +A ERS Sbjct: 150 PVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQ 209 Query: 124 LRKWYNLMIQNKDDLARI 141 L+K +L + L + Sbjct: 210 LQKEKDLAEKRAKLLEEM 227 >3BA0-A nrPDB Length = 365 Score = 31.4 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 16/41 (39%), Gaps = 3/41 (7%) Query: 91 ADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131 D + A+ +AF W V+ + S + +++ Sbjct: 18 PDMNREDVDYAI---RKAFQVWSNVTPLKFSKINTGMADIL 55 >1JIZ-A nrPDB Length = 166 Score = 31.0 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 16/41 (39%), Gaps = 3/41 (7%) Query: 91 ADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131 D + A+ +AF W V+ + S + +++ Sbjct: 25 PDMNREDVDYAI---RKAFQVWSNVTPLKFSKINTGMADIL 62 >3TFC-A nrPDB Length = 385 Score = 31.0 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 40/101 (39%), Gaps = 3/101 (2%) Query: 366 KNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNF-FEPTL 424 K L +GNG E GP + ++ E+V +KG ++ GG + F+ Sbjct: 134 KGLPIGNG-EPVFVFGP-CSVESYEQVAAVAESIKAKGLKLIRGGAFKPRTSPYDFQGLG 191 Query: 425 LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVG 465 L + + E G ++ ++ E A+ + +G Sbjct: 192 LEGLKILKRVSDEYGLGVISEIVTPADIEVALDYVDVIQIG 232 >4DYO-A nrPDB Length = 485 Score = 30.6 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 50/150 (33%), Gaps = 28/150 (18%) Query: 271 ICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSM--------------ELGGLAPFIVF 316 + T+P V ++ + G A + + + + E + I Sbjct: 296 LATEPHVRMVTLYDNEEVGSESAQGAQSLLTELVLRRISASCQHPTAFEEAIPKSFMI-- 353 Query: 317 DSANVDQAV--------AGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMK--- 365 SA++ AV F V S Q + +A ++ A +K Sbjct: 354 -SADMAHAVHPNYLDKHEENHRPLFHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPL 412 Query: 366 KNLRVGNGFEEGTTQGPLINEKAVEKVEKQ 395 ++L V N GTT GP++ + +V Sbjct: 413 QDLMVRNDTPCGTTIGPILASRLGLRVLDL 442 >5EQT-A nrPDB Length = 257 Score = 30.6 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 27/81 (33%), Gaps = 8/81 (9%) Query: 242 ELASQAGI--PSGVYNVIPCSRKNAKEVGEAICTDP-LVSKISFTGSTTTGKILLHHAAN 298 EL + GI P GV ++ K + + I GS K + A Sbjct: 29 ELFEEVGIDPPKGV--LLYGPPGCGKTLMAKALAHEVNATFIRVVGSELVRKYIGEGA-- 84 Query: 299 SVKRVSMELGG-LAPFIVFDS 318 + EL AP I+F Sbjct: 85 RLVHELFELAKEKAPTIIFID 105 >2CUN-A nrPDB Length = 410 Score = 30.2 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 26/66 (39%), Gaps = 5/66 (7%) Query: 381 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPT-----LLCNVTQDMLCT 435 G +I++ + V + + GA VV G + + + T +L + + Sbjct: 27 GKIISDARFKAVLPTIRYLIESGAKVVIGTHQGKPYSEDYTTTEEHARVLSELLDQHVEY 86 Query: 436 HEETFG 441 E+ FG Sbjct: 87 IEDIFG 92 >3LOO-A nrPDB Length = 365 Score = 29.8 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 8/49 (16%) Query: 437 EETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485 EE F P V+ F E EAIA+A + G ++D +I + L Sbjct: 226 EEIF-PYVDVL-FGNETEAIALAKEFNYG------TEDLREIGKRIAAL 266 >1FBL-A nrPDB Length = 370 Score = 29.8 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 10/27 (37%), Gaps = 3/27 (11%) Query: 91 ADCGVREARAAVRAAYEAFCRWREVSA 117 D + A+ +AF W VS Sbjct: 24 PDLSREDVDRAIE---KAFQLWSNVSP 47 >5J6F-A nrPDB Length = 368 Score = 29.8 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 31/95 (32%), Gaps = 7/95 (7%) Query: 344 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 403 LV R H E K R+G+G + GP ++ E+V +G Sbjct: 92 KALLVSRKKHPE--NTIVEV--KGERIGDG-NQYFVMGP-CAVESYEQVAAVAEAVKKQG 145 Query: 404 ATVVTGGKRHQLGKNF-FEPTLLCNVTQDMLCTHE 437 ++ GG + F+ + + E Sbjct: 146 IKLLRGGAYKPRTSPYDFQGLGVEGLKILKRIADE 180 >3DOD-A nrPDB Length = 448 Score = 29.8 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 6/30 (20%), Positives = 15/30 (50%), Gaps = 2/30 (6%) Query: 120 RSSLLRKWYNLMIQNKDDLARI--ITAESG 147 R LR+ L+ ++ +++A + + G Sbjct: 193 RDQCLRELAQLLEEHHEEIAALSIESMVQG 222 >2R6F-A nrPDB Length = 972 Score = 29.8 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 50/149 (33%), Gaps = 23/149 (15%) Query: 222 GCT-VVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 280 G T +VV+ EDT +A L ++ AG I A E + DP Sbjct: 556 GNTLIVVEHDEDTMLAADYLIDIGPGAG--------IHGGEVVAAGTPEEVMNDPN---- 603 Query: 281 SFTGSTTTGKILLHHAANSVKRV--SME-LGGLAPFIVFDSANVDQAVAGAMASKFRNTG 337 S TG +GK + A + +E +G + S + A+ +G Sbjct: 604 SLTGQYLSGKKFIPIPAERRRPDGRWLEVVGAREHNLKNVSVKIPLGTFVAVTGV---SG 660 Query: 338 QTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366 LV ++ A + A K Sbjct: 661 ----SGKSTLVNEVLYKALAQKLHRAKAK 685 >4N4Q-A nrPDB Length = 296 Score = 29.4 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 19/52 (36%), Gaps = 9/52 (17%) Query: 263 NAKEVGEAICTDPLVSKISFTGSTTTG--------KILLHHAAN-SVKRVSM 305 KEV + V I TGST K ++ A + RV++ Sbjct: 28 GVKEVVNFLVEKQKVDGIYITGSTGEFLLLSFEDKKEVMKLVAEANAGRVTL 79 >5C8D-A nrPDB Length = 305 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 14/44 (31%), Gaps = 1/44 (2%) Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICT-DPLVSKI 280 L EL AG P G ++ E+G + + Sbjct: 170 ARLQELLDLAGFPPGPPVLVTTPPGERHEIGAMLAAYHLRRKGV 213 >3UX8-A nrPDB Length = 670 Score = 29.1 bits (64), Expect = 5.0, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 50/149 (33%), Gaps = 23/149 (15%) Query: 222 GCT-VVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 280 G T +VV+ EDT +A L ++ AG I A E + DP Sbjct: 254 GNTLIVVEHDEDTMLAADYLIDIGPGAG--------IHGGEVVAAGTPEEVMNDPN---- 301 Query: 281 SFTGSTTTGKILLHHAANSVKRV--SME-LGGLAPFIVFDSANVDQAVAGAMASKFRNTG 337 S TG +GK + A + +E +G + S + A+ +G Sbjct: 302 SLTGQYLSGKKFIPIPAERRRPDGRWLEVVGAREHNLKNVSVKIPLGTFVAVTGV---SG 358 Query: 338 QTCVCSNQFLVQRGIHDAFVKAFAEAMKK 366 LV ++ A + A K Sbjct: 359 ----SGKSTLVNEVLYKALAQKLHRAKAK 383 >5C8A-A nrPDB Length = 206 Score = 29.1 bits (64), Expect = 5.6, Method: Composition-based stats. Identities = 9/44 (20%), Positives = 14/44 (31%), Gaps = 1/44 (2%) Query: 238 LALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICT-DPLVSKI 280 L EL AG P G ++ E+G + + Sbjct: 71 ARLQELLDLAGFPPGPPVLVTTPPGERHEIGAMLAAYHLRRKGV 114 >5XM3-A nrPDB Length = 627 Score = 29.1 bits (64), Expect = 5.8, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 4/62 (6%) Query: 251 SGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKIL----LHHAANSVKRVSME 306 +GV ++ +K+ + T P + I +T TG ++ + AN VK+V +E Sbjct: 336 AGVNVMMLSEQKDKNGKMRKLLTHPDRNGIIYTLDRETGDLVSANKMDDTANWVKKVDLE 395 Query: 307 LG 308 G Sbjct: 396 TG 397 >2ZDS-A nrPDB Length = 340 Score = 28.7 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 28/73 (38%), Gaps = 6/73 (8%) Query: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQV 396 G C + LV + + DA + EA+ G+G EG ++A +++ Sbjct: 64 GLKCWAISNHLVGQAVCDAIIDERHEAILPARIWGDGDAEGVR------QRAAAEIKDTA 117 Query: 397 NDAVSKGATVVTG 409 A G V G Sbjct: 118 RAAARLGVDTVIG 130 >3TW5-A nrPDB Length = 367 Score = 28.7 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 22/63 (34%), Gaps = 4/63 (6%) Query: 423 TLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVA 482 T + +VT ++ P+ ++ E + GL Y ++ + V Sbjct: 219 TFVADVTAGAEVWNQ----PVRGFKVYEQTEMTLEEGAQTFYGLEAYPWNAAAKSLVYVK 274 Query: 483 EQL 485 +L Sbjct: 275 SRL 277 >1J3N-A nrPDB Length = 408 Score = 28.3 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 30/105 (28%), Gaps = 11/105 (10%) Query: 229 PAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAK--------EVGEAICTDPLVSKI 280 P + +ALA+A AGI I + + + Sbjct: 270 PHPEGKGAALAMARALKDAGIAPEQVGYINAHGTSTPVGDRAEVLAIKRVFGDHAKRLMV 329 Query: 281 SFTGSTTTGKILLHHAANSVKRVSMEL--GGLAPFIVFDSANVDQ 323 S T S G +L A L G + P I + + + Sbjct: 330 SSTKSM-IGHLLGAAGAVEAIATVQALYHGVIPPTINLEDPDPEL 373 >3UWD-A nrPDB Length = 394 Score = 28.3 bits (62), Expect = 9.2, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 42/131 (32%), Gaps = 16/131 (12%) Query: 381 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNV--------TQDM 432 G + +E + + V +GA V+ + E L V +D+ Sbjct: 29 GKITDETRIRAALPTIQYLVEQGAKVILASHLGRPKGQAVEELRLTPVAARLGELLGKDV 88 Query: 433 LCTHEETFGPLAP-VIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVG 491 +E FGP+A ++ E + + + N D A + + Sbjct: 89 KKA-DEAFGPVAQEMVAAMNEGDVLVLENVRFY---AGEEKNDAELAKEFAALAD---IF 141 Query: 492 VNEGLISSVEC 502 VN+ ++ Sbjct: 142 VNDAFGAAHRA 152 >6EVG-A nrPDB Length = 507 Score = 28.3 bits (62), Expect = 9.6, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 25/61 (40%), Gaps = 8/61 (13%) Query: 377 GTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTH 436 G GPL+ K E V V + + +G T+ G F P++L +++ Sbjct: 61 GAYLGPLVRLKNGETVTLSVENGMDEGTTLHWHG--------LFVPSILDGGPHNVIAAG 112 Query: 437 E 437 E Sbjct: 113 E 113 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.155 0.459 Lambda K H 0.267 0.0475 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,637,069 Number of Sequences: 36641 Number of extensions: 1075882 Number of successful extensions: 4639 Number of sequences better than 10.0: 148 Number of HSP's better than 10.0 without gapping: 215 Number of HSP's successfully gapped in prelim test: 50 Number of HSP's that attempted gapping in prelim test: 3384 Number of HSP's gapped (non-prelim): 286 length of query: 535 length of database: 10,336,785 effective HSP length: 102 effective length of query: 433 effective length of database: 6,599,403 effective search space: 2857541499 effective search space used: 2857541499 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.3 bits)