BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P51648 (485 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4QGK-A nrPDB 956 0.0 3SZA-A nrPDB 661 0.0 1AD3-A nrPDB 636 0.0 5NNO-A nrPDB 408 e-114 5UCD-A nrPDB 304 6e-83 4V3F-A nrPDB 155 5e-38 4H7N-A nrPDB 154 6e-38 6QAO-A nrPDB 153 1e-37 4CAZ-A nrPDB 153 2e-37 3U4J-A nrPDB 150 1e-36 2HG2-A nrPDB 149 3e-36 3B4W-A nrPDB 148 5e-36 5FHZ-A nrPDB 148 6e-36 3IWK-A nrPDB 147 7e-36 5EUY-A nrPDB 145 3e-35 4PZ2-A nrPDB 145 6e-35 3K2W-A nrPDB 144 7e-35 2D4E-A nrPDB 144 9e-35 4O5H-A nrPDB 142 3e-34 4LIH-A nrPDB 142 3e-34 1BPW-A nrPDB 142 3e-34 5KLK-A nrPDB 142 4e-34 6C43-A nrPDB 141 7e-34 4MPY-A nrPDB 140 9e-34 5GT6-A nrPDB 140 1e-33 5AC0-A nrPDB 140 1e-33 3TY7-A nrPDB 140 2e-33 4PXL-B nrPDB 139 2e-33 5AC2-A nrPDB 139 3e-33 4I8P-A nrPDB 139 4e-33 4F3X-A nrPDB 138 5e-33 4YWE-A nrPDB 138 5e-33 4I8Q-A nrPDB 138 5e-33 3I44-A nrPDB 138 5e-33 5UR2-A nrPDB 136 2e-32 1O9J-A nrPDB 136 2e-32 6FK3-A nrPDB 135 3e-32 3IWJ-A nrPDB 135 4e-32 4GO4-A nrPDB 135 4e-32 3RJL-A nrPDB 134 1e-31 4X2Q-A nrPDB 134 1e-31 3JZ4-A nrPDB 134 1e-31 4QYJ-A nrPDB 132 3e-31 5J77-A nrPDB 132 4e-31 4V6H-A nrPDB 131 5e-31 3R31-A nrPDB 130 9e-31 1WNB-A nrPDB 130 1e-30 3RHO-A nrPDB 130 2e-30 3PRL-A nrPDB 127 1e-29 4O6R-A nrPDB 127 1e-29 3RHD-A nrPDB 126 2e-29 3QAN-A nrPDB 126 2e-29 2J5N-A nrPDB 125 4e-29 6B4R-B nrPDB 124 7e-29 4U3W-A nrPDB 124 1e-28 5L13-A nrPDB 123 1e-28 5KF0-A nrPDB 123 1e-28 3VZ3-A nrPDB 123 2e-28 5VBF-A nrPDB 122 3e-28 6MVR-A nrPDB 122 3e-28 3EFV-A nrPDB 122 5e-28 2QE0-A nrPDB 121 7e-28 2W8P-A nrPDB 120 2e-27 5U0M-A nrPDB 120 2e-27 4DNG-A nrPDB 119 3e-27 1AG8-A nrPDB 118 6e-27 5IUV-A nrPDB 118 7e-27 5X5U-A nrPDB 115 5e-26 1UXV-A nrPDB 114 1e-25 5JRY-A nrPDB 114 1e-25 4JZ6-A nrPDB 111 6e-25 3VZ0-A nrPDB 111 7e-25 1T90-A nrPDB 111 7e-25 3JU8-A nrPDB 111 7e-25 3EK1-A nrPDB 110 1e-24 4I3V-A nrPDB 110 1e-24 5J6B-A nrPDB 108 7e-24 5TJR-A nrPDB 107 1e-23 3R64-A nrPDB 105 5e-23 4ZZ7-A nrPDB 101 6e-22 3ROS-A nrPDB 101 7e-22 4OGD-A nrPDB 101 7e-22 5N5S-A nrPDB 101 8e-22 2JG7-A nrPDB 99 4e-21 3RH9-A nrPDB 95 8e-20 4KNA-A nrPDB 94 1e-19 4X0T-A nrPDB 94 1e-19 4PXN-A nrPDB 89 3e-18 4E4G-A nrPDB 87 1e-17 6DBB-A nrPDB 80 2e-15 4LGZ-A nrPDB 67 1e-11 3V9H-A nrPDB 66 3e-11 4OE4-A nrPDB 65 5e-11 5JFN-A nrPDB 55 9e-08 4IDS-A nrPDB 54 1e-07 5UJU-A nrPDB 52 8e-07 1EZ0-A nrPDB 48 9e-06 3V4C-A nrPDB 46 3e-05 5J7I-A nrPDB 43 3e-04 1O20-A nrPDB 39 0.004 1VLU-A nrPDB 38 0.011 1O6C-A nrPDB 37 0.020 6D97-A nrPDB 36 0.042 3K9D-A nrPDB 32 0.60 4GHK-A nrPDB 32 0.79 3RLI-A nrPDB 32 0.83 5DBV-A nrPDB 31 0.94 6G4F-A nrPDB 31 1.1 2H5G-A nrPDB 31 1.2 6FYQ-A nrPDB 31 1.5 3JC8-Qa nrPDB 30 2.0 5TY0-A nrPDB 30 2.0 3MCP-A nrPDB 30 2.8 5AGA-A nrPDB 29 5.1 6MFV-A nrPDB 29 5.5 6GB2-BC nrPDB 28 7.3 >4QGK-A nrPDB Length = 461 Score = 956 bits (2471), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/460 (100%), Positives = 460/460 (100%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE Sbjct: 2 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 61 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ Sbjct: 62 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 121 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH Sbjct: 122 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 181 Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT Sbjct: 182 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 241 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI Sbjct: 242 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 301 Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA Sbjct: 302 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 361 Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS Sbjct: 362 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 421 Query: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFN 460 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFN Sbjct: 422 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFN 461 >3SZA-A nrPDB Length = 469 Score = 661 bits (1706), Expect = 0.0, Method: Compositional matrix adjust. Identities = 298/439 (67%), Positives = 377/439 (85%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V Sbjct: 24 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 83 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G Sbjct: 84 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 143 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184 AIAAGNAV++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT Sbjct: 144 AIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 203 Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244 G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP Sbjct: 204 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 263 Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304 DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG Sbjct: 264 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 323 Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F Sbjct: 324 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 383 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424 S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R Sbjct: 384 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 443 Query: 425 CLLKSLKREGANKLRYPPN 443 CL++ L + K+RYPP+ Sbjct: 444 CLVRPLMNDEGLKVRYPPS 462 >1AD3-A nrPDB Length = 452 Score = 636 bits (1640), Expect = 0.0, Method: Compositional matrix adjust. Identities = 290/439 (66%), Positives = 368/439 (83%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 V+R R+AF SG++R L+FR+QQLEAL+RM+ E K I A+A+DL K+E+ Y +EV V Sbjct: 7 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 66 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 L E+D ++ LP+W +PV K T D+ YI +PLGVVL+IGAWNYPF LTIQP++G Sbjct: 67 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 126 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184 A+AAGNAVI+KPSE+S + A +LA L+PQY+DQ+LY+V+ GGV ETTELLK+RFDHI YT Sbjct: 127 AVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIMYT 186 Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244 G+TAVGKIVM AAAKHLTPVTLELGGKSPCY+DKDCDLD+ CRRI WGK+MN GQTC+AP Sbjct: 187 GSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAP 246 Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304 DYILC+ S+QNQIV K+K+++K+FYGE+ K+S DY RIIN RHF+R+ L++ QK+A GG Sbjct: 247 DYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGG 306 Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 D+++RYIAPT+L DVDP++ VMQEEIFGP++PIV V++++EAI FIN+REKPLALYVF Sbjct: 307 TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 366 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424 S+N K+IK+MI ETSSGGVT NDVI+H T+ + PFGGVG+SGMGAYHGK SF+TFSH+R Sbjct: 367 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRS 426 Query: 425 CLLKSLKREGANKLRYPPN 443 CL+KSL E A+K RYPP+ Sbjct: 427 CLVKSLLNEEAHKARYPPS 445 >5NNO-A nrPDB Length = 546 Score = 408 bits (1049), Expect = e-114, Method: Compositional matrix adjust. Identities = 216/463 (46%), Positives = 302/463 (65%), Gaps = 22/463 (4%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 V + R+AF +R L+ R Q L +L +V+E + AI D + E++ + Sbjct: 21 VSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETVVMEILPL 80 Query: 65 LGEIDFMLENLPEWVTAKPVKKNV--LTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPL 122 E+ ++E++ E+V KPVK + LD+ +Q +PLGVVL+IG WNYP +L +QPL Sbjct: 81 RNEVWHLIEHMDEYV--KPVKPTMEGAAALDDCELQYEPLGVVLVIGTWNYPLLLILQPL 138 Query: 123 IGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIF 182 +GA+AAGN +IKPSEL+ TA++L KLLP+Y+ D+ ++NGGV ETT +LK+RFDHI Sbjct: 139 LGALAAGNTAVIKPSELAPATAELLTKLLPKYVSSDVVGIVNGGVSETTAVLKERFDHIL 198 Query: 183 YTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC--DLDIVCRRITWGKYMNCGQT 240 YTG+ V +IVM AAAKHLTPVTLELGGKSP +D C ++ +V RI WGK +N GQT Sbjct: 199 YTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGKIINAGQT 258 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYG----------------ENIKESPDYERIIN 284 IAPDY++ E S+++ +V + E K G + E DY RI+N Sbjct: 259 SIAPDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQKQQFLEESDYPRIVN 318 Query: 285 LRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKN 344 HF+R++ ++G K+A GGE DEAT IAPT+LT++DP VMQEEIFGPILP++ +N Sbjct: 319 ASHFQRLMEFMKGGKVAVGGEADEATLTIAPTILTNIDPTHPVMQEEIFGPILPVLTYEN 378 Query: 345 VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGS 404 + + IN REKPLALYVFS+N + I+ + TSSG V NDV++H + PFGGVG Sbjct: 379 EKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVVHAGADGLPFGGVGR 438 Query: 405 SGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSK 447 SGMGAYHG++SF+TFSH+RP + + + +R+PP + +K Sbjct: 439 SGMGAYHGRYSFETFSHRRPVMRRGFLFSSIDTVRFPPYTTAK 481 >5UCD-A nrPDB Length = 457 Score = 304 bits (778), Expect = 6e-83, Method: Compositional matrix adjust. Identities = 166/419 (39%), Positives = 251/419 (59%), Gaps = 8/419 (1%) Query: 9 RQAFLSGRSRP-LRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGE 67 ++A+ + R+ + FR Q LE L+ V ++ + +A+A DL K + V E+ VL E Sbjct: 37 QKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEIGAVLHE 96 Query: 68 IDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIA 127 IDF L +L EWV V + E Y+ +P GV IIG +NYP LT+ PLIGAI Sbjct: 97 IDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTPLIGAII 156 Query: 128 AGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNT 187 GN IIKPSE + T+ ++ K++ + + VI GG +E + LL FD IF+TG+ Sbjct: 157 GGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSHLLSLPFDFIFFTGSP 216 Query: 188 AVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYI 247 VGK+VM+AAAKHLTPV LELGGK P + D DLD ++ +GK++N GQT IAPDY+ Sbjct: 217 NVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQTXIAPDYL 276 Query: 248 LCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQ--KIAFGGE 305 S+++ ++ ++ E VK + E +++ R +R++SLLE ++ G + Sbjct: 277 YVHYSVKDALLERLVERVK----TELPEINSTGKLVTERQVQRLVSLLEATQGQVLVGSQ 332 Query: 306 TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINERE-KPLALYVF 364 D + R ++ TV+ V+ +M EE+FGPILP++ +V AI+ +N+ KPLA+YVF Sbjct: 333 ADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPKPLAVYVF 392 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 + + K +I++ SG N V++H PFGG+G+SGMG YHG S+ TF+H++ Sbjct: 393 GKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFSYLTFTHKK 451 >4V3F-A nrPDB Length = 497 Score = 155 bits (391), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 108/343 (31%), Positives = 173/343 (50%), Gaps = 24/343 (6%) Query: 94 EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ 153 ++++ QPLGVV +I WNYP ++ + A+AAG ++KPSEL+ T ++ + Sbjct: 141 KSHVLRQPLGVVGLISPWNYPLLMATWKIAPALAAGCTAVLKPSELASVTCLEFGEVCNE 200 Query: 154 Y-LDQDLYIVING-GVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGG 210 L + ++ G G + L+ D I +TG++A G VM +AA+ + PVTLELGG Sbjct: 201 VGLPPGVLNILTGLGPDAGAPLVSHPDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGG 260 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYG 270 KSP + +D D+D V +G + GQ C A +L S+ + V K+ + K Sbjct: 261 KSPIVVFEDVDIDKVVEWTIFGCFWTNGQICSATSRLLVHESIAAEFVDKLVKWTK---- 316 Query: 271 ENIKESPDYER------IINLRHFKRILSLL-----EGQKIAFGGETDEATR---YIAPT 316 NIK S +E +I+ + +I+ + EG I +GG E + YI PT Sbjct: 317 -NIKISDPFEEGCRLGPVISKGQYDKIMKFISTAKSEGATILYGGSRPEHLKKGYYIEPT 375 Query: 317 VLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMID 376 ++TD+ ++ +EE+FGP+L + + DEAI N+ E LA VFS++ + +R+ Sbjct: 376 IVTDISTSMQIWKEEVFGPVLCVKTFSSEDEAIALANDTEYGLAAAVFSNDLERCERITK 435 Query: 377 ETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 G V N F P+GG+ SG G G+ + Sbjct: 436 ALEVGAVWVNCSQPCFV--QAPWGGIKRSGFGRELGEWGIQNY 476 >4H7N-A nrPDB Length = 474 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 121/428 (28%), Positives = 206/428 (48%), Gaps = 35/428 (8%) Query: 4 EVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 + R R+A + + R+ L+ ++ + R + + A+ D + V E+ + Sbjct: 33 QCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGRLSITVL--EIDS 90 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLI 123 L ID PE + ++ + + + P PL V +I WN+P L++ I Sbjct: 91 FLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPL--VGVISPWNFPLTLSMIDTI 148 Query: 124 GAIAAGNAVIIKPSELSEN-TAKILAKL--LPQYLDQDLYIVINGGVEETTELLKQRFDH 180 A+ AG AV++KPSE++ A +L L +P+ +D+ I + GG E L+ D Sbjct: 149 PALLAGCAVVVKPSEIAPRFVAPLLMALNTVPEL--RDVLIFVEGGGETGANLINY-VDF 205 Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240 + +TG+ A G+ V E AA+ P LELGGK P + + +L++ I WG +N GQ+ Sbjct: 206 VCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQS 265 Query: 241 CIAPDYILCEAS----LQNQIVWKIKETVKEF-------YGENIKESPDYERIINLRHFK 289 C++ + I S +Q++ K + G I E IIN Sbjct: 266 CLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEK--QAGIIN----D 319 Query: 290 RILSLLE-GQKIAFGGETDE--ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 IL +E G I GG+ +E + PTV+T+V+ KVM EE FGPI+P++P +V+ Sbjct: 320 HILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVE 379 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTL-----NSFPFGG 401 EA+ N+ L+ VF+ + ++ + ++G ++ ND + + N+F F G Sbjct: 380 EAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEKNAFNFSG 439 Query: 402 VGSSGMGA 409 +G S +GA Sbjct: 440 LGGSRVGA 447 >6QAO-A nrPDB Length = 508 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 122/440 (27%), Positives = 209/440 (47%), Gaps = 30/440 (6%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + L V+ + AF + R + L R+++ERE +I T + KS F Sbjct: 65 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-- 122 Query: 61 VITVLGEIDFMLENLPEW--VTAKPVKKNV-LTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 +ID + L + + A +++ L Y + +PLGV + IGAWNYPF + Sbjct: 123 ------DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 176 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 176 A+A GNA++ KPS + +A +LA++ + + L+ V+ GG T + L Q Sbjct: 177 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFLCQ 235 Query: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 D + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + + Sbjct: 236 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 295 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGENIKESPDYERIINLRHFKRILS 293 + GQ C + + + ++ + +K+T + G+ + E +IN H +R+L Sbjct: 296 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 355 Query: 294 LL-----EGQKIAFGGET----DEATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341 + +G K+ GG+ D + Y+ P VLT+ ++EEIFGP++ I+ Sbjct: 356 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 415 Query: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 401 E + N+ LA VF+ + + R++ E +G N+ + + PFGG Sbjct: 416 FDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGG 473 Query: 402 VGSSGMGAYHGKHSFDTFSH 421 SG G +G+ + + +S Sbjct: 474 YKKSGFGRENGRVTIEYYSQ 493 >4CAZ-A nrPDB Length = 490 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 126/417 (30%), Positives = 197/417 (47%), Gaps = 29/417 (6%) Query: 24 LQQLEALRRMV---QEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVT 80 +Q+ LRR V +ER ++ D K S +++T +++ +P Sbjct: 66 MQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEG 125 Query: 81 AK-PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSEL 139 + P+++ Y + +PLGVV IGAWNYP + + A+AAGNA+I KPSE+ Sbjct: 126 EQIPLRETSFV-----YTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEV 180 Query: 140 SENTAKILAKLLPQYLDQD-LYIVINGGVEETTELLKQR--FDHIFYTGNTAVGKIVM-E 195 + TA LA++ + D ++ V+ G E + L + + I +TG T+ GK VM Sbjct: 181 TPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMAS 240 Query: 196 AAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255 A++ L VT+ELGGKSP I D DLD + + GQ C + S Q Sbjct: 241 ASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQA 300 Query: 256 QIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLEGQK-----IAFGGE--TD 307 + K+ E V+ G+ E+ ++ +++ H + +L +E K + GGE TD Sbjct: 301 RFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTD 360 Query: 308 EA---TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 A Y+APTV TD +++EEIFGP++ I+ + DEAI N+ E LA V Sbjct: 361 GAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVV 420 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSH 421 + + R I +G N + P GG SG+G +G T +H Sbjct: 421 TQDLARAHRAIHRLEAGICWIN--TWGESPAEMPVGGYKQSGVGRENG---LTTLAH 472 >3U4J-A nrPDB Length = 528 Score = 150 bits (380), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 104/333 (31%), Positives = 172/333 (51%), Gaps = 13/333 (3%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 +P+GVV II WN+PF++ + + AI +G V++KPSE + T+ LA+L + + Sbjct: 160 EPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEFTSGTSIRLAELAREAGIPDG 219 Query: 159 LYIVINGGVEETTELLKQ--RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYI 216 ++ V+ G + ++L + D + +TG+ VG + E AA+ + V LELGGK P + Sbjct: 220 VFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGTKLGEIAARTVKRVGLELGGKGPQIV 279 Query: 217 DKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE 275 D DLD I +G Y N GQ CI+ +L + +++ ++ ++ + ++ +G+ + E Sbjct: 280 FADADLDAAADGIAYGVYHNAGQCCISGSRLLVQEGIRDALMERLLDISRKVAFGDPLNE 339 Query: 276 SPDYERIINLRHFKRILS-----LLEGQKIAFGGE--TDEATRYIAPTVLTDVDPKTKVM 328 +I+ H +++ S + G ++ GGE EA Y APTV V P + Sbjct: 340 RTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGERIGREAGLYYAPTVFAGVTPDMSIA 399 Query: 329 QEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDV 388 +EEIFGP+L + K DEA+ N E L+ V+S N + + I +G N V Sbjct: 400 REEIFGPVLSTLTFKTADEAVALANATEFGLSASVWSTNLETALQTIRRIRAGRCWINSV 459 Query: 389 IMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSH 421 I P GG SG+G G++ FD +S Sbjct: 460 IDG--TPELPIGGYKKSGLGRELGRYGFDEYSQ 490 >2HG2-A nrPDB Length = 479 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 98/341 (28%), Positives = 168/341 (49%), Gaps = 13/341 (3%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 + LGV I WN+PF L + + A+ GN ++IKPSE + N A AK++ + L + Sbjct: 141 RALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRG 200 Query: 159 LYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYI 216 ++ ++ G E + L + + TG+ + G+ +M AAK++T V LELGGK+P + Sbjct: 201 VFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIV 260 Query: 217 DKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKES 276 D DL++ + I + +N GQ C + + + + +Q V ++ E ++ N E Sbjct: 261 MDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAER 320 Query: 277 PDYER--IINLRHFKRI-----LSLLEGQKIAFGGETDEATR-YIAPTVLTDVDPKTKVM 328 D +IN +R+ ++ EG ++AFGG+ E Y PT+L DV + +M Sbjct: 321 NDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIM 380 Query: 329 QEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDV 388 EE FGP+LP+V +++AI+ N+ + L +++ N + + I G N Sbjct: 381 HEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINR- 439 Query: 389 IMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKS 429 +F G SG+G GKH + + L+S Sbjct: 440 -ENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQS 479 >3B4W-A nrPDB Length = 495 Score = 148 bits (374), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 121/424 (28%), Positives = 198/424 (46%), Gaps = 22/424 (5%) Query: 17 SRPLRFRLQQLEALRRMVQEREKDILTAI-AADLCKSEFNVYSQEVITVLGEIDFMLENL 75 S P R + A +M+ ER KD+ T + AA+ + + + + +G +++ Sbjct: 66 STPPHERAAVIAAAVKMLAER-KDLFTKLLAAETGQPPTIIETMHWMGSMGAMNY-FAGA 123 Query: 76 PEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIK 135 + VT + ++ + +P+GVV I AWN P L + + A+ AG +++K Sbjct: 124 ADKVTWTETRTG---SYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLK 180 Query: 136 PSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIV 193 P+ + TA LA++ + L + + V+ GG+E L D +TG++AVG+ V Sbjct: 181 PAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGREV 240 Query: 194 MEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASL 253 AA+ L P TLELGGKS I +D DL + + MN GQ C+ IL S Sbjct: 241 GRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSR 300 Query: 254 QNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETD 307 ++IV + V G + +I+ + R+ + EG ++ GG Sbjct: 301 YDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGRP 360 Query: 308 EATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 E +I PTV DVD K + QEEIFGP+L I+P ++AI N+ LA V+ Sbjct: 361 EGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVW 420 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLN-SFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 + + ++ + TG I + + PFGG +SG+G +G + F+ Q+ Sbjct: 421 TTDVPKGIKISQQIR----TGTYGINWYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQK 476 Query: 424 PCLL 427 LL Sbjct: 477 SVLL 480 >5FHZ-A nrPDB Length = 529 Score = 148 bits (373), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 105/357 (29%), Positives = 173/357 (48%), Gaps = 18/357 (5%) Query: 83 PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142 P NV+ + + +P+GV I WN+P ++ + L A+ GN +++KP+E + Sbjct: 174 PTDDNVV-----CFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPL 228 Query: 143 TAKILAKLLPQYLDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK 199 TA L L+ + + I G T + + I +TG+T VGK+V EAA++ Sbjct: 229 TALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASR 288 Query: 200 -HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258 +L VTLELGGK+PC + D DLD+ G + N GQ C A + E + ++ V Sbjct: 289 SNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFV 348 Query: 259 WKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATR 311 + E K+ G+ + I+ + F +IL L+ EG K+ GG ++ Sbjct: 349 RRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGL 408 Query: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371 +I PTV ++V ++ +EEIFGP+ PI+ K+++E I N + L VF+ N Sbjct: 409 FIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKA 468 Query: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 ++ SG V N + PFGG SG G G+++ ++ + +K Sbjct: 469 LKLASALESGTVWIN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 523 >3IWK-A nrPDB Length = 503 Score = 147 bits (372), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 111/346 (32%), Positives = 175/346 (50%), Gaps = 30/346 (8%) Query: 94 EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL--- 150 ++YI +P+GVV +I WNYPF++ + A+AAG A I+KPSEL+ T L ++ Sbjct: 144 KSYILKEPIGVVALITPWNYPFLMATWKIAPALAAGCAAILKPSELASVTCLELGEICKE 203 Query: 151 --LPQYLDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLE 207 LP+ + L IV G E L D I +TG++A G +M AA+ + PV+LE Sbjct: 204 VGLPRGV---LNIVTGLGHEAGASLASHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLE 260 Query: 208 LGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE 267 LGGKSP + +D DLD V +G + GQ C A ++ S+ + V K+ + Sbjct: 261 LGGKSPIVVFEDVDLDKVAEWTVFGCFFTNGQICSATSRLIVHESIAVEFVDKLVK---- 316 Query: 268 FYGENIKESPDYER------IINLRHFKRILSLL-----EGQKIAFGGETDEATR---YI 313 + ENIK S E I++ +K++L+ + EG I GG E + ++ Sbjct: 317 -WAENIKISDPLEEGCRLGPIVSEAQYKKVLNCISSAKSEGATILTGGRRPEHLKKGYFV 375 Query: 314 APTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKR 373 PT++TDV ++ +EE+FGP+L + +EAIN N+ L V S++ + +R Sbjct: 376 EPTIITDVTTSMQIWREEVFGPVLAVKTFSTEEEAINLANDTHYGLGSAVMSNDLERCER 435 Query: 374 MIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 + +G V N F P+GG+ SG G G+ + + Sbjct: 436 LSKALQAGIVWINCAQPSFI--QAPWGGIKRSGFGRELGEWGLENY 479 >5EUY-A nrPDB Length = 491 Score = 145 bits (367), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 110/419 (26%), Positives = 203/419 (48%), Gaps = 27/419 (6%) Query: 18 RPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPE 77 R + + LE R+M ++D + + + + V+ + V T + +++N E Sbjct: 69 RRAEYLYKMLEVFRQM----KEDFMKILTVEGGGTYRKVWGEVVFT-----ERLIQNAAE 119 Query: 78 WVTAKPVKKNVLTMLDEAYIQ---PQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 A+ + VL E+ I + GVV +I WNYP ++++ + +A GN V+ Sbjct: 120 --LARHYQGRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVVY 177 Query: 135 KPSELSENTAKILAKLLPQY-LDQDLY-IVINGGVEETTELL-KQRFDHIFYTGNTAVGK 191 KP+ + T ++A+++ + L + ++ +VI G E++ +R H+ +TG ++ G+ Sbjct: 178 KPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHKRVAHVTFTGESSTGR 237 Query: 192 IVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEA 251 + AA L VTLELGG P I D D+D R + + GQ C + I+ Sbjct: 238 EIAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIVHK 297 Query: 252 SLQNQIVWKIKETVKEFYGENIK--ESPDYERIINLRHFKRILSLLE-----GQKIAFGG 304 ++ ++ + + VK ++ + E D +IN R + ++ G ++ GG Sbjct: 298 AVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLIGG 357 Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 + + P + DVD ++M+EE+FGP+ PIV V+N D+A+ N+ + L+ V Sbjct: 358 RS--WGNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSGAVL 415 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 ++N R+ + SG NDV + PFGG+ +SG+G G+ SF ++ R Sbjct: 416 TNNVNRAFRIAEAVESGMFHINDVTF-LEESHVPFGGIKASGVGREGGEWSFHETTYDR 473 >4PZ2-A nrPDB Length = 534 Score = 145 bits (365), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 120/440 (27%), Positives = 203/440 (46%), Gaps = 32/440 (7%) Query: 1 MELEVRRVRQAFLSGR----SRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNV 56 ++L VR R AF G S R R+ + L +V+E ++ + D K Sbjct: 90 VDLAVRAARAAFDHGEWPRMSGSERGRI--MARLADLVEEHAGELAALESLDAGKHPAVT 147 Query: 57 YSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDE--AYIQPQPLGVVLIIGAWNYP 114 + +V G + + A + L M + + +PLGV +I WN+P Sbjct: 148 RAVDVGNAAGSLRYFAG------AADKIHGETLKMPGQFQGHTLREPLGVAGVIIPWNFP 201 Query: 115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL 174 + + A+AAG A+++KP+E + +A LA+L Q D I + G T Sbjct: 202 STMFAVKVAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAA 261 Query: 175 ---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRIT 230 D + +TG+T VG+++M+A+A+ +L PV LELGGKSP + D DLD+ Sbjct: 262 LASHMDVDMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAV 321 Query: 231 WGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESP--DYERIINLRHF 288 + N G+ C+A + + + ++ ++ E ++ + + P D ++ + Sbjct: 322 GASFFNKGEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQY 381 Query: 289 KRILSLL-----EGQKIAFGGE---TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 +R+LS + EG + GG + YI PTV T+V + +EEIFGP++ ++ Sbjct: 382 ERVLSYIDHGKREGATLLTGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLM 441 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNS-FPF 399 K V+EAI N+ L V + + + R++ +G V N +F + S PF Sbjct: 442 KFKTVEEAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVN---CYFAMGSDCPF 498 Query: 400 GGVGSSGMGAYHGKHSFDTF 419 GG SG G G H+ D + Sbjct: 499 GGRKMSGFGKDEGMHALDKY 518 >3K2W-A nrPDB Length = 497 Score = 144 bits (364), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 119/420 (28%), Positives = 191/420 (45%), Gaps = 26/420 (6%) Query: 21 RFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVT 80 R R L ++E + + + A+ K +V EV ID+ +N Sbjct: 72 RTRQNMLRTFANKIRENKHILAPMLVAEQGKL-LSVAEMEVDVTATFIDYGCDN------ 124 Query: 81 AKPVKKNVL---TMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPS 137 A ++ ++L ++ YI P GVV+ I AWN+P L + + A+ GN +++KP+ Sbjct: 125 ALTIEGDILPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPT 184 Query: 138 ELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR--FDHIFYTGNTAVGKIVM 194 + + L ++ + L + VING + L + I TG+T GK + Sbjct: 185 QETPLATTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIY 244 Query: 195 EAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQ 254 + +A+++TPV LELGGK+P + D DLD WG++ NCGQ C + + AS+ Sbjct: 245 KTSAEYMTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVY 304 Query: 255 NQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETD- 307 ++ + K VK G+ + N R I ++ +G +A GG+T Sbjct: 305 DEFMAKFLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTAT 364 Query: 308 ----EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYV 363 E + PTVL DV V+ EE FGPILPIV V ++++AI F N+ L+ YV Sbjct: 365 VEGFEGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYV 424 Query: 364 FSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 + + I + I + G V N M F G SG G GK + + ++ Sbjct: 425 HTQSFANINQAISDLEVGEVYINRG-MGEQHQGF-HNGWKQSGFGGEDGKFGLEQYLEKK 482 >2D4E-A nrPDB Length = 515 Score = 144 bits (363), Expect = 9e-35, Method: Compositional matrix adjust. Identities = 106/339 (31%), Positives = 164/339 (48%), Gaps = 23/339 (6%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDL 159 P G V II WN P +L+ + A+A GN V++KP+E S TA LA++L + L + Sbjct: 162 PAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGV 221 Query: 160 YIVINGGVEETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYID 217 + ++ G EE L + TG T GKIVM AA HL ++ ELGGKSP + Sbjct: 222 FNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVF 281 Query: 218 KDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKES 276 D DL+ + + + G+ C A +L E + V K+ E + G + Sbjct: 282 ADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFEDFVGKVVERARAIRVGHPLDPE 341 Query: 277 PDYERIINLRHFKRILSLL-----EGQKIAFGGETDEAT---------RYIAPTVLTDVD 322 + +I+ H +R+L + EG ++ GGE + + Y+ PTV + Sbjct: 342 TEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVGEN 401 Query: 323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382 K+ QEEIFGP+L +P K+ +EA+ N+ + LA YVF+ + + R+ E +G Sbjct: 402 -HMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGM 460 Query: 383 VTGNDV-IMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 V N + H PFGGV SG G ++ D ++ Sbjct: 461 VYLNSHNVRHLPT---PFGGVKGSGDRREGGTYALDFYT 496 >4O5H-A nrPDB Length = 511 Score = 142 bits (359), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 92/345 (26%), Positives = 166/345 (48%), Gaps = 14/345 (4%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLL--P 152 AY + +P+GVV I WN+P ++ + A+A G V++KP+E + +A L +L+ Sbjct: 168 AYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPAEDTPLSALRLGELIQAA 227 Query: 153 QYLDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 + D + IV G L + R D I +TG+T GK + AA ++T ++LELGGK Sbjct: 228 GFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQTGKTIGHAALDNMTRMSLELGGK 287 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270 SP + D DLD + + + N GQ C A + + + ++ ++ + G Sbjct: 288 SPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSKVFDGVIERVAKIAASLKIG 347 Query: 271 ENIKESPDYERIINLRHFKRILSLLEGQKIAFGGET------DEATRYIAPTVLTDVDPK 324 + + +++ + +R+ ++ D ++ PTVL D Sbjct: 348 PGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGGRAIDGPGFFVEPTVLVDTTQA 407 Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384 +V++EEIFGP+L +P +VD A+ N+ L ++S++ I +++ ++G V Sbjct: 408 MRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIWSNDLSAIHKLVPRIAAGTVW 467 Query: 385 GNDVIMHFTL-NSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 N H L N+ PFGG+ SG G G+ D ++ + ++ Sbjct: 468 VN---CHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSVMMN 509 >4LIH-A nrPDB Length = 504 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 102/330 (30%), Positives = 166/330 (50%), Gaps = 14/330 (4%) Query: 111 WNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEE 169 WN+P ++ A+AAGN+V++KPSE S TA +A+L + ++ V+ G E Sbjct: 175 WNFPILMAAWKFGPALAAGNSVVLKPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAGEP 234 Query: 170 TTEL-LKQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDC-DLDIVC 226 L L + D I +TG+TAVGK++M+ AA+ +L LELGGKSP + DC DLD Sbjct: 235 GKLLALHRDVDCIAFTGSTAVGKLIMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAA 294 Query: 227 RRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINL 285 + + N G+ C A +L +++ + K+ + + G + S I++ Sbjct: 295 QTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDG 354 Query: 286 RHFKRILSLL-----EGQKIAFGGETDEATR--YIAPTVLTDVDPKTKVMQEEIFGPILP 338 +R+L + EG+ + G + T Y+ PTV +V P K+ +EEIFGP+L Sbjct: 355 IQLERVLGYIEAGRGEGRLVTGGARVNAETGGFYVEPTVF-EVKPDAKIAREEIFGPVLS 413 Query: 339 IVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFP 398 ++ +VDEA+ N+ E LA V++ N + +G V N +N FP Sbjct: 414 VIVFDDVDEAVRIANDTEYGLAAAVWTSNLTTAHDVSRRLRAGTVWVNCYDEGGDMN-FP 472 Query: 399 FGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 FGG SG G H+ + ++ + L++ Sbjct: 473 FGGYKQSGNGRDKSLHALEKYTELKSTLIR 502 >1BPW-A nrPDB Length = 503 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 101/349 (28%), Positives = 166/349 (47%), Gaps = 17/349 (4%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154 AY + +PLGV I AWNYPF++ A+A GNAV+ KPS ++ T ILA++ + Sbjct: 149 AYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEA 208 Query: 155 -LDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKS 212 + L V+ GG E + L + +TG+ GK VME +AK + VTLELGGKS Sbjct: 209 GVPVGLVNVVQGGAETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKS 268 Query: 213 PCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGE 271 P I KDC+L+ R ++ GQ C + + + Q + + +K T G+ Sbjct: 269 PLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGD 328 Query: 272 NIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE----TDEATR---YIAPTVLT 319 + +I+ ++L + EG ++ GGE +D + +++P VL Sbjct: 329 PLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLD 388 Query: 320 DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETS 379 + ++EEIFGP++ ++P +E + N LA VF+ + R+ Sbjct: 389 NCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLE 448 Query: 380 SGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 +G N + PFGG SG G +G+ + D +S + +++ Sbjct: 449 AGTCYIN--TYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVE 495 >5KLK-A nrPDB Length = 520 Score = 142 bits (358), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 100/342 (29%), Positives = 166/342 (48%), Gaps = 20/342 (5%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY- 154 Y +PLGV+ +I W+ P +L + A+A GN V+ KPSE S ++A +LA+++ Sbjct: 173 YTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPSEESPSSATLLAEVMHDAG 232 Query: 155 LDQDLYIVING-GVEETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 + ++ +I+G G + E L Q + +TG + G +M+A A + V+ ELGGK Sbjct: 233 VPPGVFNLIHGFGKDSAGEFLTQHPGISALTFTGESKTGSTIMKAVADGVKEVSFELGGK 292 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIK-ETVKEFYG 270 + + D DLD + + N GQ C+ + + S+ ++ V +K E + G Sbjct: 293 NAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVG 352 Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGG-------ETDEATRYIAPTVL 318 ++ + +I+ H ++LS EG + GG E D+ Y+ PT+ Sbjct: 353 YPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGVPKFNDERDQGA-YVQPTIW 411 Query: 319 TDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDET 378 T + K + + EEIFGP+ I P + DE IN +N+ LA +++ N R+ + Sbjct: 412 TGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSNYGLACAIWTTNLSRAHRVSRQI 471 Query: 379 SSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 G V N + PFGGV SG+G G+ S D +S Sbjct: 472 HVGLVWVNTWYLRDLRT--PFGGVKLSGLGREGGRFSMDFYS 511 >6C43-A nrPDB Length = 477 Score = 141 bits (355), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 99/343 (28%), Positives = 161/343 (46%), Gaps = 14/343 (4%) Query: 97 IQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD 156 I+ P+GVV I WNYP ++ L A+AAGN V+IKPSE++ TA LA L Sbjct: 137 IRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAVLAKDIFP 196 Query: 157 QDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPC 214 + V+ G + ++L ++ + TG+ A G+ ++ A + +ELGGK+P Sbjct: 197 PGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPV 256 Query: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENI 273 + D DLD V + + + N GQ C A I + + + +V K+ V G Sbjct: 257 IVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLKMGAPE 316 Query: 274 KESPDYERIINLRHFKRILSLLEGQK-------IAFGGETDEATRYIAPTVLTDVDPKTK 326 ES + + +L H KR+ + +E K I G +T+ Y APT+L D + Sbjct: 317 DESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADAKQEDA 376 Query: 327 VMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386 ++Q E+FGP++ I + D+ + + N+ LA V++ + R+ G N Sbjct: 377 IVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYGCTWIN 436 Query: 387 DVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 HF L S P GG SG G + + ++ R ++K Sbjct: 437 ---THFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVK 476 >4MPY-A nrPDB Length = 520 Score = 140 bits (354), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 98/340 (28%), Positives = 169/340 (49%), Gaps = 16/340 (4%) Query: 94 EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ 153 E+ I +P+GVV I WNYP + + A+A G ++++KPSE++ T + +L+ + Sbjct: 163 ESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEITPLTTIRVFELMEE 222 Query: 154 Y-LDQDLYIVINGGVEETTELLK--QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGG 210 + +I G E +++ + D + +TG GK +M+ AA ++T + LELGG Sbjct: 223 VGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGGIETGKHIMKNAANNVTNIALELGG 282 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-Y 269 K+P I D D ++ + G Y + GQ C A IL + S++++ + + VK+ Sbjct: 283 KNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKL 342 Query: 270 GENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATR-----YIAPTVLT 319 G + +I+ H +I S + EG IA GG+ + + PTV+T Sbjct: 343 GNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVIT 402 Query: 320 DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETS 379 + D +++QEE+FGP++ + + EAI N+ LA VFS + +R+ ++ Sbjct: 403 NCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLK 462 Query: 380 SGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 G V ND +F P+GG SG+G GK + + Sbjct: 463 LGTVWINDFHPYFA--QAPWGGYKQSGIGRELGKEGLEEY 500 >5GT6-A nrPDB Length = 508 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 119/442 (26%), Positives = 206/442 (46%), Gaps = 38/442 (8%) Query: 1 MELEVRRVRQAFLSGRSRPLRF--RLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 ++ V+ R AF SG + R + L +++E +++ A D K Y Sbjct: 73 IDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKP----YQ 128 Query: 59 QEVITVLGEIDFMLENL---PEWVT-----AKPVKKNVLTMLDEAYIQPQPLGVVLIIGA 110 + + +I +EN W T P+ K+ L Y + +P+GVV I Sbjct: 129 ---VALDDDISATVENYRYYAGWTTKIIGQTIPISKDYLN-----YTRHEPVGVVGQIIP 180 Query: 111 WNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ--YLDQDLYIVINGGVE 168 WN+P V++ + A+A G +++KP+E + + AKL + + + + V G E Sbjct: 181 WNFPLVMSSWKMGAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPE 240 Query: 169 ETTELLKQR-FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCR 227 ++ D + +TG+T GK +M +A+ + VTLELGGKSP I +D DL+ Sbjct: 241 AGAAIVNHHDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNIILEDADLEEAIN 300 Query: 228 RITWGKYMNCGQTCIAPDYILCEASLQNQIV---WKIKETVKEFYGENIKESPDYERIIN 284 G N GQ C A + +V K+ VK G +++ + +++ Sbjct: 301 GAFQGIMYNHGQNCSAGSRVFVHRKHYETVVDALVKMANNVK--LGAGMEKETEMGPLVS 358 Query: 285 LRHFKRILSLL-----EGQKIAFGGETD-EATRYIAPTVLTDVDPKTKVMQEEIFGPILP 338 + +R+L+ + EG +A GGE E ++ PTV TDV +++EEIFGP++ Sbjct: 359 KKQQERVLNYIEQGKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVV 418 Query: 339 IVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFP 398 ++P + +E I N LA V++ N K ++ ++ +G V ND + + P Sbjct: 419 VLPFDSTEEVIERANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWINDYNLENA--AAP 476 Query: 399 FGGVGSSGMGAYHGKHSFDTFS 420 FGG SG+G G ++ D ++ Sbjct: 477 FGGYKQSGIGRELGSYALDNYT 498 >5AC0-A nrPDB Length = 501 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 126/449 (28%), Positives = 210/449 (46%), Gaps = 42/449 (9%) Query: 5 VRRVRQAFLSG---RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 V+ RQAF G R+ R + L L ++ ER++ +L + A + ++S Sbjct: 64 VKAARQAFQIGSPWRTMDASERGRLLNKLADLI-ERDRLLLATMEA---MNGGKLFSNAY 119 Query: 62 ITVLGEIDFMLENLPEWVT-----AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116 + LG L W P+ N T Y + +P+GV I WN+P + Sbjct: 120 LMDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFT-----YTRSEPVGVCGQIIPWNFPLL 174 Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL-- 174 + + + A++ GN V++KP+E + TA + L+ + + I G T Sbjct: 175 MFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAIS 234 Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 D + +TG+T VGK++ EAA K +L V+LELGGKSPC + D DLD G Sbjct: 235 SHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQG 294 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGEN-----IKESPDYERIINLRH 287 + + GQ CIA + E S+ ++ V + E K++ N + + P I+ Sbjct: 295 VFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQ----IDKEQ 350 Query: 288 FKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341 +++IL L+ EG K+ GG +I PTV +DV ++ +EEIFGP+ I+ Sbjct: 351 YEKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMK 410 Query: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNS--FPF 399 K++D+ I N L+ +F+++ I + I SS +G + +++ S PF Sbjct: 411 FKSLDDVIKRANNTFYGLSAGIFTND---IDKAI-TVSSALQSGTVWVNCYSVVSAQCPF 466 Query: 400 GGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 GG SG G G++ F ++ + +K Sbjct: 467 GGFKMSGNGRELGEYGFHEYTEVKTVTIK 495 >3TY7-A nrPDB Length = 478 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 111/430 (25%), Positives = 199/430 (46%), Gaps = 28/430 (6%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 V +L R ++ R L+ + + + R+ DI+ AI +L +++ Sbjct: 51 VEAADDVYLEFRHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAP---------LSL 101 Query: 65 LGEIDFMLENLPEWVTAKPVKKN--VLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPL 122 + + + L +V A+ N + + + +GV +I WN+P T L Sbjct: 102 SERVHYQM-GLNHFVAARDALDNYEFEERRGDDLVVKEAIGVSGLITPWNFPTNQTSLKL 160 Query: 123 IGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ--RFD 179 A AAG+ V++KPSE + A ILA++ + + + ++ ++NG L + + Sbjct: 161 AAAFAAGSPVVLKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVR 220 Query: 180 HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQ 239 + +TG+ G +ME AAK V+LELGGKSP + D D+ + T N GQ Sbjct: 221 MMSFTGSGPTGSKIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQ 280 Query: 240 TCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKE-SPDYERIINLRHFKRILSLL--- 295 C A +L +++ + ++KE + N +E II+ + F ++ + + Sbjct: 281 VCTAGTRVLVPNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKG 340 Query: 296 --EGQKIAFGG----ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAI 349 EG ++ +GG E E + PT+ +VD + + QEEIFGP++ ++ ++DEAI Sbjct: 341 IEEGAELFYGGPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAI 400 Query: 350 NFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 409 N+ + LA YV + + + ++ +G V N+ L PFGG SG+G Sbjct: 401 QIANDTKYGLAGYVIGKDKETLHKVARSIEAGTVEINEAGRKPDL---PFGGYKQSGLGR 457 Query: 410 YHGKHSFDTF 419 G + + F Sbjct: 458 EWGDYGIEEF 467 >4PXL-B nrPDB Length = 517 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 102/341 (29%), Positives = 163/341 (47%), Gaps = 21/341 (6%) Query: 94 EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL--- 150 Y +P+GVV I WNYP + + A+AAG AV++KP+E + +A A L Sbjct: 167 HGYTLKEPVGVVGHIVPWNYPTTMFFFKVGPALAAGCAVVVKPAEQTPLSALFYAHLARE 226 Query: 151 --LPQYLDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAK-HLTPVTL 206 +P + L +V G + D + +TG+T VG++VM AAA+ +L PV+L Sbjct: 227 AGVPAGV---LNVVPGFGPTAGAAVAAHMDVDKVSFTGSTEVGRLVMRAAAESNLKPVSL 283 Query: 207 ELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKE-TV 265 ELGGKSP + D DLD+ + + Y N G+ C+A I + + ++ V K E Sbjct: 284 ELGGKSPVIVFDDADLDMAVNLVNFATYTNKGEICVAGTRIYVQEGIYDEFVKKAAELAS 343 Query: 266 KEFYGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLT 319 K G+ S ++ ++++L + EG + GG+ + YI PT+ T Sbjct: 344 KSVVGDPFNPSVSQGPQVDKDQYEKVLRYIDIGKREGATLVTGGKPCGDKGYYIEPTIFT 403 Query: 320 DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETS 379 DV + Q+EIFGP++ ++ K V+E I N LA + + N + + Sbjct: 404 DVKDDMTIAQDEIFGPVMALMKFKTVEEVIQKANNTRYGLAAGIVTKNIDVANTVSRSIR 463 Query: 380 SGGVTGNDVIMHFTLN-SFPFGGVGSSGMGAYHGKHSFDTF 419 +G + N +F + PFGG SG G G + D + Sbjct: 464 AGAIWIN---CYFAFDPDAPFGGYKMSGFGKDMGMDALDKY 501 >5AC2-A nrPDB Length = 501 Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 126/447 (28%), Positives = 202/447 (45%), Gaps = 38/447 (8%) Query: 5 VRRVRQAFLSG---RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 V+ RQAF G R+ R + L L ++ ER++ +L + + + +YS Sbjct: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLI-ERDRLLLATMES---MNGGKLYSNAY 119 Query: 62 ITVLGEIDFMLENLPEWVT-----AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116 + L L W P+ N T Y + +P+GV I WN+P V Sbjct: 120 LNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFT-----YTRHEPIGVCGQIIPWNFPLV 174 Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL-- 174 + I + A++ GN V++KP+E + TA +A L+ + + I G T Sbjct: 175 MLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAIS 234 Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 D + +TG+T VGK++ EAA K +L VTLELGGKSPC + D DLD G Sbjct: 235 SHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHG 294 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGEN-----IKESPDYERIINLRH 287 + + GQ CIA I E S+ ++ V + E K++ N + + P I+ Sbjct: 295 VFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQ----IDKEQ 350 Query: 288 FKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341 + +IL L+ EG K+ GG ++ PTV ++V + ++ +EEIFGP+ I+ Sbjct: 351 YDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMK 410 Query: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 401 K++D+ I N L+ VF+ + + +G V N PFGG Sbjct: 411 FKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGG 468 Query: 402 VGSSGMGAYHGKHSFDTFSHQRPCLLK 428 SG G G++ F ++ + +K Sbjct: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495 >4I8P-A nrPDB Length = 520 Score = 139 bits (349), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 118/425 (27%), Positives = 196/425 (46%), Gaps = 39/425 (9%) Query: 19 PLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEW 78 P R + L A+ V ER+ ++ A D C ++ + ++ V G ++ + Sbjct: 87 PGAVRAKYLRAIAAKVIERKPELAKLEALD-CGKPYDEAAWDMDDVAGCFEYFADQ---- 141 Query: 79 VTAKPVKKNVLTMLD----EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 A ++N L + +++ +P+GVV +I WNYP ++ + A+AAG ++ Sbjct: 142 AEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVL 201 Query: 135 KPSELSENTAKILAKL-----LPQYLDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTA 188 KPSEL+ T LA + LP + L IV G + L D + +TG+ Sbjct: 202 KPSELASVTCLELADICKEVGLPSGV---LNIVTGLGPDAGAPLSAHPDVDKVAFTGSFE 258 Query: 189 VGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYIL 248 GK +M +AA + PVTLELGGKSP + D D+D +G + GQ C A +L Sbjct: 259 TGKKIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLL 318 Query: 249 CEASLQNQIVWKIKETVKEFYGENIKESPDYER------IINLRHFKRILSLL-----EG 297 + +I K E + + +NIK S E +++ +++I + +G Sbjct: 319 ----IHTKIAKKFNERMVA-WAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQG 373 Query: 298 QKIAFGGETD---EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINE 354 I GG E +I PT++TD+ ++ +EE+FGP+L + DEAI N+ Sbjct: 374 ATILTGGVRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELAND 433 Query: 355 REKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKH 414 + LA V S + + +R+ +E +G + N F P+GG SG G G+ Sbjct: 434 TQYGLAGAVISGDRERCQRLSEEIDAGCIWVNCSQPCFC--QAPWGGNKRSGFGRELGEG 491 Query: 415 SFDTF 419 D + Sbjct: 492 GIDNY 496 >4F3X-A nrPDB Length = 498 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 104/344 (30%), Positives = 160/344 (46%), Gaps = 16/344 (4%) Query: 97 IQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD 156 I+ P+G+V I WNYP ++ L AI GN V+ KPSE + TA LA+L+ L Sbjct: 157 IRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSEQTPLTALKLARLIADILP 216 Query: 157 QDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPC 214 + + VI G E L + + TG+ A GK V+ AAAK + LELGGK+P Sbjct: 217 EGVVNVITGRGETVGNALINHPKVGMVSITGDIATGKKVLAAAAKTVKRTHLELGGKAPV 276 Query: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENI 273 + D DL+ V I Y N GQ C A I EA + ++V + V Y + Sbjct: 277 IVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIYEKLVADLTSAVSTIRYNLDD 336 Query: 274 KESPDYERIINLRHFKRILSLLE---GQK---IAFGGET--DEATRYIAPTVLTDVDPKT 325 + +I+ R R+ S +E QK I GG T DE + PTV+ + Sbjct: 337 DTENEIGPLISRRQRDRVASFVERAADQKHIEITTGGRTGSDEGF-FFQPTVVAGATQED 395 Query: 326 KVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTG 385 ++++ E+FGP++ + D+A+ + N+ + LA V++ + R G Sbjct: 396 EIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVWTKDISKAMRAASRLQYGCTWI 455 Query: 386 NDVIMHFTL-NSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 N HF L N P GG+ SG G ++ + ++ R ++ Sbjct: 456 N---THFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIMIN 496 >4YWE-A nrPDB Length = 487 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 103/336 (30%), Positives = 157/336 (46%), Gaps = 19/336 (5%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ--YLDQ 157 +P GV I WNYP + + + A+AAGNA ++KP+E + + +A+L + Sbjct: 146 EPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAEDACLSVLRVAELAAEAGLPAG 205 Query: 158 DLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYI 216 L IV G E L + DHI +TG+ A GK+V + AA++ PVTLELGGKSP + Sbjct: 206 ALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQMAAENHVPVTLELGGKSPQIV 265 Query: 217 DKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKES 276 D DLD + N GQTC A +L E ++ +V ++ + Sbjct: 266 FADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYEPLVERLATAFNGLRVGPSRAD 325 Query: 277 PDYERIINLRHFKRILSLL------------EGQKIAFGGETDEATRYIAPTVLTDVDPK 324 D +IN + +R+ L GQ +A + E+ Y AP +L DV P Sbjct: 326 LDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVA---DAPESGFYQAPALLRDVPPS 382 Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384 ++ QEE+FGP+L + + DEA+ N L +++ + R+ +G V Sbjct: 383 HRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWTRDGARQMRLARRLRAGQVF 442 Query: 385 GNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 N+ + PFGGVG SG G G + F+ Sbjct: 443 INNYGAGGGVE-LPFGGVGHSGHGREKGFEALYGFT 477 >4I8Q-A nrPDB Length = 514 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 104/343 (30%), Positives = 168/343 (48%), Gaps = 23/343 (6%) Query: 94 EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ 153 ++Y+ +PLGVV +I WNYP ++ I + A+AAG A I+KPSEL+ T L ++ + Sbjct: 157 KSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPSELASITCLELGEICRE 216 Query: 154 --YLDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGG 210 L I+ G E L D I +TG+ G +M AAA+ + PV+L LGG Sbjct: 217 IGLPSGALNILTGLGPEAGGPLASHPHVDKISFTGSGPTGSKIMTAAAQLVKPVSLALGG 276 Query: 211 KSPCYIDKDCD-LDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV-----WKIKET 264 KSP + D D LDI +G + N GQ C A ++ + ++ + + W Sbjct: 277 KSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIK 336 Query: 265 VKEFYGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATR---YIAPT 316 + + E+ K P +++ ++++L + EG I GGE + + Y+ PT Sbjct: 337 ISDPLEEDCKLGP----VVSAGQYEKVLKFISNAKSEGATILCGGERPQHLKKGYYVQPT 392 Query: 317 VLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMID 376 ++TDV+ ++ +EE+FGP+L + K ++AI N+ + L V S + K +R Sbjct: 393 IITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLGAAVMSKDVKRCERFTK 452 Query: 377 ETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 +G + N T N P+GG SG G GK + F Sbjct: 453 AFQTGIIWIN--CSQPTFNELPWGGKKRSGFGRDLGKWGLENF 493 >3I44-A nrPDB Length = 497 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 110/415 (26%), Positives = 194/415 (46%), Gaps = 21/415 (5%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 + ++AF + ++ RL +E + + ++R D+ I+ ++ + + T Sbjct: 69 INAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTATG 128 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 I ++ E+ ++ ++ ++A + +GVV +I WN+P +I Sbjct: 129 SSHIRNFIKAYKEF----SFQEALIEGNEQAILHYDAIGVVGLITPWNWPMNQVTLKVIP 184 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFD--HI 181 A+ AG +++KPSE++ +A + A++L + L ++ +ING L D I Sbjct: 185 ALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHPDLEMI 244 Query: 182 FYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTC 241 +TG+T GK + + A+ L V LELGGK I D D+D + R + Y N GQ+C Sbjct: 245 SFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADIDALQRGVRHCFY-NSGQSC 303 Query: 242 IAPDYILCEASLQNQIVWKIKETV-KEFYGENIKESPDYERIINLRHFKRILSLL----- 295 AP +L E ++ ++ + K+ K G + +++ + +I L+ Sbjct: 304 NAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSGID 363 Query: 296 EGQKIAFGGET----DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINF 351 EG + GG E Y+ PTV DV P ++ +EEIFGP+L ++P DEA+ Sbjct: 364 EGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAVTL 423 Query: 352 INEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 N+ E L Y+ S + +R+ + SG V +V H FGGV SG Sbjct: 424 ANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMV---EVNGHELPGGSYFGGVKFSG 475 >5UR2-A nrPDB Length = 984 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 96/346 (27%), Positives = 162/346 (46%), Gaps = 14/346 (4%) Query: 103 GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYI 161 GV +I WN+P + + A AGN V++KP+E S A L K++ + Q + Sbjct: 633 GVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQSTVVAWGLMKMIQEAGFPQGVIN 692 Query: 162 VINGGVEETTE-LLKQRFDH-IFYTGNTAVGKIVMEAAA------KHLTPVTLELGGKSP 213 + G EE E ++ ++ I +TG+ AVG +M AA +H+ +E+GGK+ Sbjct: 693 FLPGYGEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNA 752 Query: 214 CYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENI 273 ID D DLD + + + GQ C A ++ + ++ V ++ ET K Sbjct: 753 VIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDEVYDRFVDRLVETAKSIEIHPA 812 Query: 274 KESPDY-ERIINLRHFKRILSLL----EGQKIAFGGETDEATRYIAPTVLTDVDPKTKVM 328 + Y +++ + RIL + + K+ F G + PT+ DV K+ Sbjct: 813 ENPKAYMGPVVDKEAYDRILGTIAEAEKNHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLA 872 Query: 329 QEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDV 388 Q EIFGP++ ++ KN+D+A++ N E L VFS + I R+ +E G + N Sbjct: 873 QAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFSRSPANINRVKEELEVGNLYVNRG 932 Query: 389 IMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREG 434 I ++ PFGG SG+G+ G + + C+ ++ R G Sbjct: 933 ITGAMVDRHPFGGFKMSGIGSKTGGPDYLKQYMEPACVTENTLRRG 978 >1O9J-A nrPDB Length = 501 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 103/347 (29%), Positives = 169/347 (48%), Gaps = 17/347 (4%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154 +Y + +P+GV +I WN P +L + A+ GN VI+KP+E + TA +A L+ + Sbjct: 153 SYTRHEPIGVCGLIFPWNAPMILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEA 212 Query: 155 LDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGG 210 + I G T D + +TG+T VGK++ EAAAK +L VTLELG Sbjct: 213 GFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGA 272 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-Y 269 K+PC + D DLD G + N GQ+CIA + E ++ ++ V + E K++ + Sbjct: 273 KNPCIVFADADLDSAVEFAHQGVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVF 332 Query: 270 GENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDP 323 G + ++ IN +I+ L+ EG K+ GG +I PTV ++V Sbjct: 333 GNPLTPGVNHGPQINKAQHNKIMELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTD 392 Query: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS--G 381 ++ +EEIFGP+ I+ K++DE I N L VF+ K + + + +S+ Sbjct: 393 DMRIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYGLVAGVFT---KDLDKAVTVSSALQA 449 Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 G + + + S P GG SG G G++ ++ + +K Sbjct: 450 GTVWVNCYLAASAQS-PAGGFKMSGHGREMGEYGIHEYTEVKTVTMK 495 >6FK3-A nrPDB Length = 536 Score = 135 bits (341), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 106/338 (31%), Positives = 160/338 (47%), Gaps = 31/338 (9%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 +PLGVV II A N+P + LI A+ GN V+ KPSE + + + AKL + L Sbjct: 153 RPLGVVGIITAGNFPIAVPSWKLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPG 212 Query: 159 LYIVINGGVEETT-----ELLKQR-FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKS 212 + V+ GG + +T EL+ + F +TG+T VG+ + E A ++L TLELGGK+ Sbjct: 213 VLNVVFGGGKGSTGQWMVELMDEGLFQKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKN 272 Query: 213 PCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGEN 272 P + +D DLD+ W + GQ C + IL +A + + + E V+ N Sbjct: 273 PLVVMRDADLDLAVEGAWWSAFATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVGN 332 Query: 273 IKESPD--YERIINLRHFKRI-----LSLLEGQKIAFG--------------GETDEATR 311 P+ Y IN R F R + EG ++ FG G+ EA Sbjct: 333 PLLHPEVTYGPFINERFFARWQEHYRVGEAEGARLLFGRGRITRENPYPRFLGD-PEAGL 391 Query: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371 Y PTV +V P T++ EE+FGP + +V V ++EAI N L+ +++ NH+ Sbjct: 392 YGWPTVW-EVRPGTRLFTEEVFGPTINLVKVDGIEEAIAVANSTPYGLSSAIYT-NHRHW 449 Query: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 409 + G+T + PFGGV +SG G Sbjct: 450 AYLFKVGIRAGMTSINNATVGAEAHLPFGGVKASGNGG 487 >3IWJ-A nrPDB Length = 503 Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 115/410 (28%), Positives = 202/410 (49%), Gaps = 17/410 (4%) Query: 23 RLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAK 82 R + L A+ V E++ ++ + D C + + ++ V G ++ +L E + A+ Sbjct: 74 RARYLRAIAAKVTEKKPELAKLESID-CGKPLDEAAWDIDDVAGCFEYY-ADLAEKLDAR 131 Query: 83 PVKKNVLTMLD-EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141 L M ++++ +P+GVV +I WNYP ++ + A+AAG A I+KPSEL+ Sbjct: 132 QKAPVSLPMDTFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAILKPSELAS 191 Query: 142 NTAKILAKLLPQY-LDQDLYIVING-GVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAA 198 T L ++ + L + ++ G G E L D + +TG++A G +M AAA Sbjct: 192 LTCLELGEICKEVGLPPGVLNILTGLGPEAGAPLATHPDVDKVAFTGSSATGSKIMTAAA 251 Query: 199 KHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258 + + PV+LELGGKSP + +D DLD +G + GQ C A ++ S+ + + Sbjct: 252 QLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHESIATEFL 311 Query: 259 WKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATR- 311 +I + +K + ++E +++ +++IL + EG I GG E + Sbjct: 312 NRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGGSRPEHLKK 371 Query: 312 --YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHK 369 +I PT++TDV ++ +EE+FGP+L + +EAI+ N+ L V S++ + Sbjct: 372 GFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGAAVISNDLE 431 Query: 370 LIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 +R+ +G V N FT P+GGV SG G G+ D + Sbjct: 432 RCERVTKAFKAGIVWVNCSQPCFT--QAPWGGVKRSGFGRELGEWGLDNY 479 >4GO4-A nrPDB Length = 495 Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 95/342 (27%), Positives = 165/342 (48%), Gaps = 17/342 (4%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE-NTAKILAKLLPQY 154 Y+Q +P+GVV I WN+P + T + A+AAGN ++IKPSE++ +T +I+ + Sbjct: 133 YVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPLSTLRIVELMTEVG 192 Query: 155 LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKS 212 + + V+ G + L + D I +TG+TA G+ ++EA+ +L + LELGGK Sbjct: 193 FPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVEASKSNLKRIQLELGGKG 252 Query: 213 PCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGE 271 + +D +++ W + N GQ CIA ++ + +Q + + K G+ Sbjct: 253 ANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFLERFIALAKSIRLGD 312 Query: 272 NIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET--DEATR---YIAPTVLTDV 321 + + + + R+LS + +G K+ GG+ D+A Y+ PTV+ + Sbjct: 313 PMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDDKALANGFYVEPTVV-EA 371 Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381 P+ +V QEE+FGP + +V + +EA+ N E L +++ N +M +G Sbjct: 372 KPQDRVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQNLARAHKMAHAIHAG 431 Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 N PFGGVG SG G G + ++ R Sbjct: 432 MCWIN--CYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEAR 471 >3RJL-A nrPDB Length = 538 Score = 134 bits (337), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 102/366 (27%), Positives = 160/366 (43%), Gaps = 27/366 (7%) Query: 68 IDFM---LENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 IDFM + E KPV Y P GV ++I WN+ F + + Sbjct: 139 IDFMEYYARQMIELAKGKPVNSREGERNQYVYT---PTGVTVVIPPWNFLFAIMAGTTVA 195 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFDH--- 180 I GN V++KP+ + A ++L + L + + + G E + L DH Sbjct: 196 PIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYL---VDHPKT 252 Query: 181 --IFYTGNTAVGKIVMEAAAK------HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 I +TG+ VG + E AAK HL V E+GGK +D+DCD+++ + I Sbjct: 253 SIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTS 312 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKE-TVKEFYGENIKESPDYERIINLRHFKRI 291 + GQ C A + + ++++ ++ E T + GE +I+ F +I Sbjct: 313 AFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKI 372 Query: 292 LSLLE-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 + +E G+ ++ G D +I PT+ D+DPK ++MQEEIFGP++ V + D Sbjct: 373 MDYIEIGKEEGRLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFD 432 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 EA+ N E L V + N I R E G + N + PFGG SG Sbjct: 433 EALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 407 MGAYHG 412 + G Sbjct: 493 TDSKAG 498 >4X2Q-A nrPDB Length = 504 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155 + + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ + Sbjct: 157 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 216 Query: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211 I I G T D I +TG+T VGK++ EAA + +L VTLELGGK Sbjct: 217 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 276 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270 SP I D DLD + G + N GQ C A I E S+ + V + E K G Sbjct: 277 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 336 Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPK 324 + + I+ + + +IL L+ EG K+ GG+ +I PTV ++V Sbjct: 337 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 396 Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384 ++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V Sbjct: 397 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 456 Query: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 N + LN+ PFGG SG G G+ +S + +K Sbjct: 457 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 498 >3JZ4-A nrPDB Length = 481 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 90/333 (27%), Positives = 167/333 (50%), Gaps = 18/333 (5%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQD 158 QP+GV I WN+P + + A+AAG +++KP+ + +A LA+L + + Sbjct: 144 QPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAG 203 Query: 159 LYIVING-----GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSP 213 ++ V+ G G E T+ L ++ +TG+T +G+ +ME AK + V+LELGG +P Sbjct: 204 VFNVVTGSAGAVGNELTSNPLVRKLS---FTGSTEIGRQLMEQCAKDIKKVSLELGGNAP 260 Query: 214 CYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GEN 272 + D DLD K+ N GQTC+ + + + + ++ K+++ + + + G+ Sbjct: 261 FIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAMSKLHIGDG 320 Query: 273 IKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE-ATRYIAPTVLTDVDPKTK 326 + +I+ + ++ +L +G ++ GG+ E + PT+L DV K Sbjct: 321 LDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAHERGGNFFQPTILVDVPANAK 380 Query: 327 VMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386 V +EE FGP+ P+ K+ + I N+ E LA Y ++ + + R+ + G V N Sbjct: 381 VSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGIN 440 Query: 387 DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 I+ + PFGG+ +SG+G K+ + + Sbjct: 441 TGIISNEVA--PFGGIKASGLGREGSKYGIEDY 471 >4QYJ-A nrPDB Length = 516 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 92/348 (26%), Positives = 169/348 (48%), Gaps = 20/348 (5%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQ 153 A Q P+GVV I WN+P ++ + + A+A GN V++KP+E + TA LA+L + Sbjct: 172 ASTQRVPVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPAEETPLTALRLAELAMEA 231 Query: 154 YLDQDLYIVINGGVEETTELLKQ--RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 L V+ G E + L + + + +TG+T VG+I+ A + L V+LELGGK Sbjct: 232 GLPAGALNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIGSACGRSLKAVSLELGGK 291 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK---IKETVKEF 268 SP + DCD + N GQ C A + S+ ++ + I E++ Sbjct: 292 SPVIVLADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESIYEDVIQRLAVIGESI--V 349 Query: 269 YGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDEATR--YIAPTVLTDV 321 G +++ +++ +H + +L + +G + GG + ++ PT+ + Sbjct: 350 VGSGLEQGVHMGPMVSKKHHENVLRHIRNGIEDGADLICGGTEAPCAQGFFVKPTIFANR 409 Query: 322 DPK-TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 380 + K +++ +E+FGP+L P ++ E +N N L +++++ R+ DE + Sbjct: 410 EKKDIRLLSQEVFGPVLVATPFSDIAEVVNEANRSVYGLGASIWTNDLSAALRINDELEA 469 Query: 381 GGVTGNDVIMHFTLN-SFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLL 427 G V N H ++ + PFGG SG+G HG + + ++ R ++ Sbjct: 470 GTVWVN---THNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTRSLVI 514 >5J77-A nrPDB Length = 508 Score = 132 bits (331), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 79/285 (27%), Positives = 148/285 (51%), Gaps = 15/285 (5%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAK-ILAKLLPQYLDQDL 159 P G+V+ + WN+P + + L A+ GN V++KPS + +A+ I+ K + + + + Sbjct: 138 PYGIVVALTPWNFPAGMVARKLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGV 197 Query: 160 YIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYID 217 I G E + + ++ + I TG+TA G+ +M+ A+ ++ + LELGGK+P + Sbjct: 198 LNFITGRGSEIGDYIVEHKKVNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVW 257 Query: 218 KDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESP 277 KD D+D + + W KY N GQ+CIA + + + + + + E ++ + K + Sbjct: 258 KDADMDNALKTLLWAKYWNAGQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPKNA- 316 Query: 278 DYERIINLRHFKRILSLLE-----GQKIAFGGETDEAT------RYIAPTVLTDVDPKTK 326 D +IN + ++E G KI FGG + + PT++ + D K+K Sbjct: 317 DMGPLINKGALQATSEIVEEAKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSK 376 Query: 327 VMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371 + QEEIF P++ + +V+E + N+ + LA Y+F+ + +I Sbjct: 377 IFQEEIFAPVIGARKISSVEEMYDLANDNKYGLASYLFTKDPNII 421 >4V6H-A nrPDB Length = 484 Score = 131 bits (330), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 108/407 (26%), Positives = 184/407 (45%), Gaps = 24/407 (5%) Query: 31 RRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVT--AKPVKKNV 88 R + R D++ A + DL + + GEI + + EW K V + Sbjct: 74 RAAILRRWFDLVIANSDDLALILTTEQGKPLAEAKGEIAYAASFI-EWFAEEGKRVAGDT 132 Query: 89 LTMLD---EAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAK 145 L D + +P+GV I WN+P + + + A+AAG +++KP+E + +A Sbjct: 133 LPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVVKPAESTPFSAL 192 Query: 146 ILAKLLPQY-LDQDLYIVING-----GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAK 199 +A L + + + + V+ G G E T+ + ++ +TG+TAVG+++M +A Sbjct: 193 AMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLS---FTGSTAVGRLLMAQSAP 249 Query: 200 HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVW 259 + +TLELGG +P + D DLD KY N GQTC+ + + + Sbjct: 250 TVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHERVYDAFAD 309 Query: 260 KIKETVKEF-YGENIKESPDYERIINLRHFKRILS-----LLEGQKIAFGGETDE-ATRY 312 K+ V + G + +IN K++ S L +G + GG+ + Sbjct: 310 KLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGKRHALGHGF 369 Query: 313 IAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK 372 PTVLT V P V +EE FGP+ P+ + +E + N+ E LA Y++S + + Sbjct: 370 FEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLYSRDIGRVW 429 Query: 373 RMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 R+ + G V N ++ + PFGGV SG+G + D + Sbjct: 430 RVAEALEYGMVGINTGLISNEVA--PFGGVKQSGLGREGSHYGIDDY 474 >3R31-A nrPDB Length = 517 Score = 130 bits (328), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 103/352 (29%), Positives = 163/352 (46%), Gaps = 16/352 (4%) Query: 93 DEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTA-KILAKLL 151 D AY + PLGV + IGAWNYP + A+ AGNA++ KPSE + A KI L+ Sbjct: 142 DFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNAMVFKPSENTPLGALKIAEILI 201 Query: 152 PQYLDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209 L + L+ VI G +T LL D + TG+ G+ V AAA HL VT+ELG Sbjct: 202 EAGLPKGLFNVIQGD-RDTGPLLVNHPDVAKVSLTGSVPTGRKVAAAAAGHLKHVTMELG 260 Query: 210 GKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIK-ETVKEF 268 GKSP + D D++ G + + GQ C + + + + + +K T Sbjct: 261 GKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRVFVQKKAKARFLENLKRRTEAMI 320 Query: 269 YGENIKESPDYERIINLRHFKRILSLLEGQK------IAFGGETDEAT---RYIAPTVLT 319 G+ + + +++ +++LS +E K I GG + Y+ PTV Sbjct: 321 LGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLITGGGIPNNVAGEGAYVQPTVFA 380 Query: 320 DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETS 379 DV + +EEIFGP++ ++ + DE + N E LA VF+ + R++D Sbjct: 381 DVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATEFGLAGGVFTADLARAHRVVDGLE 440 Query: 380 SGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431 +G + N + PFGG SG G + + + +S + + + K Sbjct: 441 AGTLWIN--TYNLCPVEIPFGGSKQSGFGRENSAAALEHYSELKTVYVSTGK 490 >1WNB-A nrPDB Length = 495 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 96/343 (27%), Positives = 160/343 (46%), Gaps = 14/343 (4%) Query: 97 IQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD 156 I+ PLGVV I WNYP ++ L A+AAGN V++KPSE++ TA LA+L Sbjct: 155 IRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFP 214 Query: 157 QDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPC 214 + ++ G + + L + + TG+ A G+ ++ A + +ELGGK+P Sbjct: 215 AGVVNILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPV 274 Query: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENI 273 + D D++ V + Y N GQ C A I + + + +V K+ V G Sbjct: 275 IVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPD 334 Query: 274 KESPDYERIINLRHFKRILSLLEGQ------KIAFGGETDEATR-YIAPTVLTDVDPKTK 326 ES + + +L H +R+ +E K+ GGE + Y APT+L Sbjct: 335 DESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDA 394 Query: 327 VMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386 ++Q+E+FGP++ + P N ++ +N+ N+ + LA V++ + R+ G N Sbjct: 395 IVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVN 454 Query: 387 DVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 HF L S P GG SG G + + ++ R ++K Sbjct: 455 ---THFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVK 494 >3RHO-A nrPDB Length = 517 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 106/356 (29%), Positives = 177/356 (49%), Gaps = 30/356 (8%) Query: 81 AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELS 140 A+P + LT + +P+GV I+ WNYP ++ +AAGN V+IKP++++ Sbjct: 165 ARPNRNLTLT-------KKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVT 217 Query: 141 ENTAKILAKL-LPQYLDQDLYIVINGGVEETTELLKQRF-DH-----IFYTGNTAVGKIV 193 TA A+L L + + + ++ G + L+ QR DH I +TG+T VGK + Sbjct: 218 PLTALKFAELTLKAGIPKGVVNILPG----SGSLVGQRLSDHPDVRKIGFTGSTEVGKHI 273 Query: 194 MEAAA-KHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEAS 252 M++ A ++ V+L+LGGKSP I DCDL+ + + N G+ CIA + E S Sbjct: 274 MKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEES 333 Query: 253 LQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-E 305 + NQ V K+ E V++ G ++ ++ + H ++++ + EG + GG + Sbjct: 334 IHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQ 393 Query: 306 TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVK--NVDEAINFINEREKPLALYV 363 + PTV TDV+ + +EE FGPI+ I +VD ++ N E LA V Sbjct: 394 VPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGV 453 Query: 364 FSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 F+ + + D+ +G V N + T + PFGG SG G G+ + + + Sbjct: 454 FTRDINKALYVSDKLQAGTVFIN--TYNKTDVAAPFGGFKQSGFGKDLGEAALNEY 507 >3PRL-A nrPDB Length = 505 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 102/340 (30%), Positives = 162/340 (47%), Gaps = 11/340 (3%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKP-SELSENTAKILAKLLPQ 153 A ++ +PLGVVL I +NYP L + A+ GN V+ KP ++ S + K++ L Sbjct: 146 ALVEREPLGVVLAISPFNYPVNLAAAKIAPALVTGNTVVFKPATQGSLSGIKMVEALADA 205 Query: 154 YLDQDLYIVINGGVEETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 + + V+ G + L + D I +TG T G+ + E A + PV LELGGK Sbjct: 206 GAPEGIIQVVTGRGSVIGDHLVEHPGIDMITFTGGTTTGERISEKA--KMIPVVLELGGK 263 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271 P + D DL + +I G + GQ C A + + S+ +Q+V IKE V++ Sbjct: 264 DPAIVLDDADLKLTASQIVSGAFSYSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVG 323 Query: 272 NIKESPDYERIINLRHFKRILSL----LEGQKIAFGGETDEATRYIAPTVLTDVDPKTKV 327 + ++ D +I+ + I L LE G + ++PT+L DV P +V Sbjct: 324 SPEDDADITPVIDEKSAAFIQGLIDDALENGATLLSGNKRQGN-LLSPTLLDDVTPAMRV 382 Query: 328 MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387 EE FGP+LPI+ VK+ +EAI+ N+ + L +F+ + + G V N Sbjct: 383 AWEEPFGPVLPIIRVKDANEAISLSNQSDYGLQASIFTKDTDRAINIGKHLEVGTVHIN- 441 Query: 388 VIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLL 427 + FPF GV SG+G K S + + +R +L Sbjct: 442 AKTERGPDHFPFLGVKKSGLGVQGIKPSLLSMTRERVTVL 481 >4O6R-A nrPDB Length = 496 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 91/343 (26%), Positives = 159/343 (46%), Gaps = 18/343 (5%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE-NTAKILAKLLPQY 154 Y+Q P+GVV I WN+P + T + A+AAGN V++KPSE++ +T +I+ + Sbjct: 141 YVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEITPLSTLRIVELMAEVG 200 Query: 155 LDQDLYIVINGGVEETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKS 212 + ++ G + L + I +TG+TA G+ ++EA+ +L V LELGGK Sbjct: 201 FPAGVVNIVPGYGHTAGQRLAEHPGVGKIAFTGSTATGRRIVEASQGNLKRVQLELGGKG 260 Query: 213 PCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGE 271 + D +LD W + N GQ CIA ++ + + + + G Sbjct: 261 ANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLVLHERIADAFLERFVALASSIRIGN 320 Query: 272 NIKESPDYERIINLRHFKRILSLLE-----GQKIAFGGETDEATR-----YIAPTVLTDV 321 + + + + + +H R+LS ++ G ++ GG + Y+ PT++ Sbjct: 321 PLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGSAPQDPALANGYYVRPTIVEAK 380 Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381 +V QEE+FGP + ++ + DEA+ N E L +++++ RM +G Sbjct: 381 HATDRVAQEEVFGPFVTVLRFGSDDEALAIANATEYGLGSGLWTNDLSRAHRMAARIDAG 440 Query: 382 GVTGNDVIMHFTLN-SFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 N + +N PFGGVG SG G G + ++ R Sbjct: 441 MCWIN---CYKRVNPGSPFGGVGKSGYGREMGFEAMHDYTEAR 480 >3RHD-A nrPDB Length = 486 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 93/345 (26%), Positives = 174/345 (50%), Gaps = 20/345 (5%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE----NTAKILAKLL 151 + + +P+G+V I +N+P L+ + AIA GN ++ PS + AKI+ L Sbjct: 125 FTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIELAKIIENAL 184 Query: 152 PQY-LDQDLYIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 208 +Y + +Y ++ G E + ++ ++ + I +TG++ VG+++ + A + LEL Sbjct: 185 KKYNVPLGVYNLLTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKAG--FKKIALEL 242 Query: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF 268 GG +P + KD DL+ + G ++ GQ CI+ IL + S+ ++ + K Sbjct: 243 GGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFIEMFVNKAKVL 302 Query: 269 -YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATRYIAPTVLTDVD 322 G + E D +I++ H + + ++ EG K+ GG+ D+A Y PT+L +VD Sbjct: 303 NVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGKRDKALFY--PTIL-EVD 359 Query: 323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382 + + E F P++PI+ N +E I+ N E L +F+++ + + GG Sbjct: 360 RDNILCKTETFAPVIPIIRT-NEEEMIDIANSTEYGLHSAIFTNDINKSLKFAENLEFGG 418 Query: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLL 427 V ND + F ++ PFGGV SG+G K++ + S+ + ++ Sbjct: 419 VVINDSSL-FRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 462 >3QAN-A nrPDB Length = 538 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 95/330 (28%), Positives = 150/330 (45%), Gaps = 21/330 (6%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL- 159 P+GV + I WN+ + + + I GN V++KP+ T + AK + D L Sbjct: 172 PMGVTVTISPWNFALAIMVGTAVAPIVTGNTVVLKPAS---TTPVVAAKFVEVLEDAGLP 228 Query: 160 YIVINGGVEETTELLKQRFDH-----IFYTGNTAVGKIVMEAAA------KHLTPVTLEL 208 VIN E+ DH I +TG+ VG + E AA HL V +E+ Sbjct: 229 KGVINYVPGSGAEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEM 288 Query: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF 268 GGK +D+D DLD+ I + GQ C A + + ++++ K K Sbjct: 289 GGKDTVVVDRDADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNL 348 Query: 269 YGENIKESPDY-ERIINLRHFKRILSLLE-GQK---IAFGGETDEATRY-IAPTVLTDVD 322 + +Y +I+ + F++I+S +E G+K + GGE D +T + I PT++ D+D Sbjct: 349 TVGDPTNRDNYMGPVIDEKAFEKIMSYIEIGKKEGRLMTGGEGDSSTGFFIQPTIIADLD 408 Query: 323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382 P+ +MQEEIFGP++ + D A+ N E L V + N I++ E G Sbjct: 409 PEAVIMQEEIFGPVVAFSKANDFDHALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGN 468 Query: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 + N + PFGG SG + G Sbjct: 469 LYFNRNCTGAIVGYHPFGGFKMSGTDSKAG 498 >2J5N-A nrPDB Length = 516 Score = 125 bits (314), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 91/327 (27%), Positives = 148/327 (45%), Gaps = 16/327 (4%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENT-AKILAKLLPQYLDQDL 159 PLG ++I WN+P + ++G +A GN VI KP+E + AK+ + Sbjct: 173 PLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVIAKPAEDAVVVGAKVFEIFHEAGFPPGV 232 Query: 160 YIVINGGVEETTELLKQ--RFDHIFYTGNTAVGKIVMEAAAKHLTP-------VTLELGG 210 + G EE L + R I +TG+ VG + EAA + L P +E GG Sbjct: 233 VNFLPGVGEEVGAYLVEHPRIRFINFTGSLEVGLKIYEAAGR-LAPGQTWFKRAYVETGG 291 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYG 270 K +D+ D D+ + Y GQ C A ++ ++ ++ + + Sbjct: 292 KDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAASRLILTQGAYEPVLERVLKRAERLSV 351 Query: 271 ENIKESPDYERIINLRHFKRILSLLE-----GQKIAFGGETDEATRYIAPTVLTDVDPKT 325 +E+PD +++ +++LS +E GQ + G + +IAPTV T+V PK Sbjct: 352 GPAEENPDLGPVVSAEQERKVLSYIEIGKNEGQLVLGGKRLEGEGYFIAPTVFTEVPPKA 411 Query: 326 KVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTG 385 ++ QEEIFGP+L ++ VK+ EA+ N+ L V+S + ++ E G + Sbjct: 412 RIAQEEIFGPVLSVIRVKDFAEALEVANDTPYGLTGGVYSRKREHLEWARREFHVGNLYF 471 Query: 386 NDVIMHFTLNSFPFGGVGSSGMGAYHG 412 N I + PFGG SG A G Sbjct: 472 NRKITGALVGVQPFGGFKLSGTNAKTG 498 >6B4R-B nrPDB Length = 497 Score = 124 bits (312), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 96/348 (27%), Positives = 165/348 (47%), Gaps = 26/348 (7%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 +P+GVV I WN+P +++ L A+A GN+VI+KPSE S TA +A+L + + + Sbjct: 156 EPVGVVAAIVPWNFPLLMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKG 215 Query: 159 LYIVINGGVEETTELLKQRF--DHIFYTGNTAVGKIVM-EAAAKHLTPVTLELGGKSPCY 215 ++ V+ G + L D + +TG+T + K +M A ++ V LE GGKSP Sbjct: 216 VFNVLPGYGHTVGKALALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNI 275 Query: 216 IDKDC-DLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENI 273 + D DL N G+ C A +L E S++++ + + E +K + G + Sbjct: 276 VFADAPDLKAAAEAAAGAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPL 335 Query: 274 KESPDYERIINLRHFKRILSLLE-----GQKIAFGGE---TDEATRYIAPTVLTDVDPKT 325 + +++ + +LS +E G K+ GG+ + Y+ PT+ V Sbjct: 336 DPETNVGALVDTQQMNTVLSYIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAM 395 Query: 326 KVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV-- 383 K+ +EEIFGP+L ++ ++ +EA+ N+ LA V++ N +G V Sbjct: 396 KIAREEIFGPVLSVIEFEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWV 455 Query: 384 ---TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 G D+ + PFGG SG G H+FD ++ + +K Sbjct: 456 NQYDGGDM-------TAPFGGFKQSGNGRDKSLHAFDKYTELKATWIK 496 >4U3W-A nrPDB Length = 505 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 94/341 (27%), Positives = 160/341 (46%), Gaps = 18/341 (5%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY- 154 Y+ +PLGV+ II WN P +L + A+A GN V+ KPSE + ++A +LA+++ Sbjct: 157 YVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKPSEETPSSATLLAEVMHDVG 216 Query: 155 LDQDLYIVING-GVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 L ++ +I+G G E L + D I +TG + G +M+A A + V+ ELGGK Sbjct: 217 LPPGVFNLIHGHGQNAAGEFLTRHPDISAITFTGESRTGSTIMKAVADGVKEVSFELGGK 276 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270 + + D D D + + N GQ C+ + + E + + V +KE + G Sbjct: 277 NAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVERPIFERFVAALKEQAQALRVG 336 Query: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFG------GETDEATRYIAPTVLT 319 + +I+ H ++LS EG + G G+ + ++ PT+ T Sbjct: 337 APEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGGAPSFGDARDDGAFVMPTIWT 396 Query: 320 DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETS 379 + + ++EEIFGP+ I P + E + +N+ LA +++ R+ + Sbjct: 397 GLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGLAASIWTTQLARGHRVAKQIE 456 Query: 380 SGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 +G V N + PFGG SG+G G+HS D +S Sbjct: 457 TGIVWVNAWFVRDLRT--PFGGTKLSGLGREGGRHSLDFYS 495 >5L13-A nrPDB Length = 517 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 97/347 (27%), Positives = 159/347 (45%), Gaps = 17/347 (4%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154 +Y + +P+GV I WN+P ++ L A+A GN V++K +E + TA +A L+ + Sbjct: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228 Query: 155 LDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAA-AKHLTPVTLELGG 210 + I G T + D + +TG+T +G+++ AA + +L VTLELGG Sbjct: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFY 269 KSP I D D+D + + + N GQ C A + + ++ V + + Sbjct: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348 Query: 270 GENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDP 323 G + ++ FK+IL + EG K+ GG + +I PTV DV Sbjct: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408 Query: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV 383 + +EEIFGP++ I+ K ++E + N LA VF+ + + +G V Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468 Query: 384 TGN--DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 N DV F S PFGG SG G G++ ++ + +K Sbjct: 469 WVNCYDV---FGAQS-PFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511 >5KF0-A nrPDB Length = 485 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 107/383 (27%), Positives = 182/383 (47%), Gaps = 34/383 (8%) Query: 54 FNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNY 113 F V S+E + + GE+ LE ++A+ Y + P+G I +N+ Sbjct: 117 FRVASEEAVRIDGEV-LNLE-----ISARAQGYT-------GYTRRVPIGPCSFISPFNF 163 Query: 114 PFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVI----NGGVE 168 P L + A+AAG ++KP+ + A I+A++L + L + + V+ +G Sbjct: 164 PLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGADL 223 Query: 169 ETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC--DLDIVC 226 TT+ +RF + +TG+ AVG + E A K V LELGG + +D D LD V Sbjct: 224 FTTD---ERFRLLSFTGSPAVGWALKEKAGKK--KVVLELGGNAAAIVDADQFEQLDYVV 278 Query: 227 RRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDY-ERIINL 285 R+ +G Y GQ+CI IL ASL + + K+ + + K+ + +I+ Sbjct: 279 DRLAFGAYYQSGQSCIGVQRILVHASLYDTLRDKLVAKTRSLKMGDPKDPSTFVGPMISE 338 Query: 286 RHFKRILSLLE-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 +R+ ++ G KI GG+ D A T+L DV + + ++E FGP+ + Sbjct: 339 SESRRLSGWMDAAVAAGAKIIAGGKVDGAM--FEATLLEDVGREQDLYRKEAFGPVAILE 396 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFG 400 D+A+ +N+ + L VF+ + +R DE GGV NDV F +++ P+G Sbjct: 397 KFDRFDDALARVNDSDFGLQAGVFTDSLTHAQRAWDELEVGGVVINDV-PSFRVDNMPYG 455 Query: 401 GVGSSGMGAYHGKHSFDTFSHQR 423 GV SG+G +++ + + R Sbjct: 456 GVKDSGLGREGIRYAIEDMTEPR 478 >3VZ3-A nrPDB Length = 457 Score = 123 bits (309), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 95/352 (26%), Positives = 158/352 (44%), Gaps = 19/352 (5%) Query: 90 TMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAK 149 T E+Y+ QPLG++L + WN+PF + A+ AGN ++K + A + Sbjct: 112 TQATESYVCYQPLGILLAVMPWNFPFWQVFRFAAPALMAGNVAVLKHASNVPQCALAVEA 171 Query: 150 LL-----PQYLDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTP 203 +L P+ + Q L I G + +++K R TG+ G + A + + P Sbjct: 172 ILEAAGFPEGVFQTLLI----GASQVEQVIKDPRVKAATLTGSEPAGASLASLAGQEIKP 227 Query: 204 VTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKE 263 LELGG P + DLD T + MN GQ+ IA + ++ + + K+ Sbjct: 228 TLLELGGSDPFVVFPSADLDEAVEVGTVARTMNNGQSAIAAKRFILHEAIAAEFLEKLHL 287 Query: 264 TVKEF-YGENIKESPDYERIIN---LRHFKRIL--SLLEGQKIAFGGET-DEATRYIAPT 316 G+ + D + L+ R + ++ G KI GG D A + PT Sbjct: 288 KFASLKIGDPMAPETDIGPLATEGILQDISRQVDQAVAAGAKILLGGRPLDRAGYFYPPT 347 Query: 317 VLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMID 376 +LT++ P K++QEE+F P+ + VK++D+AI N+ L ++++ +R I Sbjct: 348 ILTEIPPGAKILQEELFAPVAMVFTVKDLDQAIALANDIPFGLGASAWTNDPAEQQRFIQ 407 Query: 377 ETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 E +G V N ++ + PFGG SG G G TF + + LK Sbjct: 408 ELDAGAVFINGMVK--SDPRLPFGGTKRSGYGRELGLAGIRTFVNAKTVWLK 457 >5VBF-A nrPDB Length = 478 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 94/339 (27%), Positives = 158/339 (46%), Gaps = 30/339 (8%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-----LPQY 154 +P+GV WN+PF + + A+A+G +++K E S + LA+L LP Sbjct: 141 EPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPSAIVALAQLFHDAGLPPG 200 Query: 155 LDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPC 214 ++ V ++ E + R I +TG+ VGK + AA + +T+ELGG +P Sbjct: 201 CLNIVWGVPGDVSKQLIEAPQVR--KISFTGSVPVGKQLAALAASLMKRMTMELGGHAPV 258 Query: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKE---TVKEFYGE 271 + D D++ + K+ N GQ C++P + + ++ V + T++ YG Sbjct: 259 LVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFVCAYLDAVGTIRVGYGL 318 Query: 272 NIKESPDYERIINLRHFKRILSL--------LEGQKIAFGG-ETDEATRYIAPTVLTDVD 322 + + + L H +R+ + +G +IA GG Y APTV+ Sbjct: 319 DAGVT-----MGPLAHARRVDEIDAFVADATAKGAQIATGGMRLPGPGHYFAPTVVLGPT 373 Query: 323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382 T++M +E FGPI+ IVP ++D+A+ N LA Y F+ + + R+ +G Sbjct: 374 RDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSARNAHRISRALEAGM 433 Query: 383 VTGNDVIMHFTLN--SFPFGGVGSSGMGAYHGKHSFDTF 419 V I HF + PFGGV SG G+ G +FD + Sbjct: 434 VN----INHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGY 468 >6MVR-A nrPDB Length = 767 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 89/332 (26%), Positives = 154/332 (46%), Gaps = 13/332 (3%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDL 159 PLGV + WN+P ++ + A+A GN V++KP+E + TA + A + Q + + Sbjct: 155 PLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTALLFADICGQAGVPAGV 214 Query: 160 YIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKD 219 ++ G ++ + D + +TG+TAVG+ + EA A ++LELGGK P + D Sbjct: 215 VNIVTGDGAVGEMIVTAQVDKVAFTGSTAVGRRIREATAGTGKALSLELGGKGPYVVCDD 274 Query: 220 CDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPD 278 D+D + + N GQ C A +L + + + K++ + G+ + + D Sbjct: 275 ADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHAKLRARMDSLRIGDPLDKCID 334 Query: 279 YERIINLRHFKRILSLLEGQKIAFGGETDE----ATRYIAPTVLTDVDPKTKVMQEEIFG 334 +++ R+ ++ GE + A Y PT+++ + P + +MQ+EIFG Sbjct: 335 IGAMVHPDQLARVRDMVAANT---DGEVYQTAVPAGCYYPPTLISGLAPASPLMQQEIFG 391 Query: 335 PILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTL 394 P+L + EA+ N LA V+S N L + + +G V N M Sbjct: 392 PVLVSTTFRTPAEAVEIANNTAYGLAASVWSENVNLALDLAPKLVAGIVWINGTNMMDA- 450 Query: 395 NSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCL 426 + PFGGV SG G G ++ RP + Sbjct: 451 -AAPFGGVRESGFGREGGWEGLAGYT--RPAI 479 >3EFV-A nrPDB Length = 462 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 103/406 (25%), Positives = 174/406 (42%), Gaps = 19/406 (4%) Query: 23 RLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAK 82 R Q L + + ++ +++ I ++ K EV D+ E+ P + + Sbjct: 53 RAQTLRDIGQALRAHAEEMAQCITREMGKP-IKQARAEVTKSAALCDWYAEHGPAMLNPE 111 Query: 83 PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142 P L +A I+ +PLGV+L I WN+P ++ + + AGN+ ++K + Sbjct: 112 PT----LVENQQAVIEYRPLGVILAIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTG 167 Query: 143 TAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKH 200 A+++A++L + +Y +N E ++++ R + TG+ G + A Sbjct: 168 CAQMIARILAEAGTPAGVYGWVNANNEGVSQMINDPRIAAVTVTGSVRAGAAIGAQAGAA 227 Query: 201 LTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK 260 L LELGG P + D DL++ + G+Y N GQ C A + E + + Sbjct: 228 LKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDR 287 Query: 261 IKETVKEF-YGENIKESPDYERI--INLR---HFKRILSLLEGQKIAFGGETDEAT-RYI 313 G+ + E D + +LR H + S+ EG ++ GGE Y Sbjct: 288 FVAAAAALKMGDPLVEENDLGPMARFDLRDELHQQVQASVAEGARLLLGGEKIAGEGNYY 347 Query: 314 APTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKR 373 A TVL DV P ++E+FGP+ I K+ A+ N+ E L+ +F+ + L Sbjct: 348 AATVLADVTPDMTAFRQELFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAE 407 Query: 374 MIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG---AYHGKHSF 416 M GGV N + FGGV SG G ++ G H F Sbjct: 408 MAARLECGGVFING--YSASDARVAFGGVKKSGFGRELSHFGLHEF 451 >2QE0-A nrPDB Length = 475 Score = 121 bits (304), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 91/339 (26%), Positives = 157/339 (46%), Gaps = 9/339 (2%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154 A ++ +P+G+VL I +NYP L + A+ AGN + KP + +LA+ + Sbjct: 137 AVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEA 196 Query: 155 -LDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 L ++ I G E + + Q + I +TG+T +G+ + + A + P+ L LGGK Sbjct: 197 GLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAG--MRPIMLALGGK 254 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271 + +D DL++ + I G + GQ C A +L S+ +++V KI+E V Sbjct: 255 DSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIG 314 Query: 272 NIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATR---YIAPTVLTDVDPKTKVM 328 N ++ D +I+ + + L+ E R I P + V ++ Sbjct: 315 NPEDDADITPLIDTKSADYVEGLINDANDKGATALTEIKREGNLICPILFDKVTTDMRLA 374 Query: 329 QEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDV 388 EE FGP+LPI+ V +V+EAI N+ E L +F+++ + ++ G V N+ Sbjct: 375 WEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFPRAFGIAEQLEVGTVHINNK 434 Query: 389 IMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLL 427 T N FPF G SG G K+S + + + + Sbjct: 435 TQRGTDN-FPFLGAKKSGAGIQGVKYSIEAMTTVKSVVF 472 >2W8P-A nrPDB Length = 487 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 110/433 (25%), Positives = 190/433 (43%), Gaps = 39/433 (9%) Query: 7 RVRQAFLSGRSRPLR----FRLQQLEALRRMVQEREKDILTAIAADLCKSEFNV--YSQE 60 R R+ RS LR +Q + L R++ L ++ S F + +S+E Sbjct: 63 RWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEE 122 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V G+I P K A + QP+GV +I WN+P + + Sbjct: 123 ARRVYGDI-----------IHTPAKDR------RALVLKQPIGVAAVITPWNFPSAMITR 165 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ--- 176 + A+AAG V++KP+E + +A LA+L Q + +Y VI + E+ + Sbjct: 166 KVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICT 225 Query: 177 --RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 I +TG+T GKI++ AA + V++ELGG +P + ++D K+ Sbjct: 226 DPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKF 285 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKE--FYGENIKESPDYERIINLRHFKRIL 292 N GQT + + L + + + V E +K+ G +E +IN + +++ Sbjct: 286 RNTGQTAVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVE 345 Query: 293 -----SLLEGQKIAFGGETDE-ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 ++ +G + GG+ + + PT+L +V EE FGP+ P++ + Sbjct: 346 KQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEE 405 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 EAI N + LA Y +S + I R+ ++ G V N+ ++ PFGGV SG Sbjct: 406 EAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSG 463 Query: 407 MGAYHGKHSFDTF 419 +G K+ D + Sbjct: 464 LGREGSKYGIDEY 476 >5U0M-A nrPDB Length = 497 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 105/427 (24%), Positives = 197/427 (46%), Gaps = 38/427 (8%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ VR R+AFL+ R + L R +EA +++ ++++ I + K + + E Sbjct: 50 VDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESRT-E 108 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V ++G+I ++ E + +V A ++ +P GVV + G +N+P L Sbjct: 109 VAAMMGKIPISVKAYNE--RTGHTESDVAG--GHAVLRHRPHGVVAVFGPYNFPGHLPNG 164 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQR--F 178 ++ A+ AGN V+ KPSEL+ A++ +L + D I + G +T + L + Sbjct: 165 HIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGLPDGVINLVQGGSDTGKCLARHSLI 224 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPV-TLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 D +F+TG++ VG ++ E + LE+GG +P + DLD +++ Sbjct: 225 DGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAFLSA 284 Query: 238 GQTCIAPDYILC-EASLQNQIVWKIKE-----TVKEFYGENIKESPDYERIINLRHFKRI 291 GQ C +L + ++ + ++ E TV EF + P +I+ ++ Sbjct: 285 GQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAEF---DADPQPFMGSVISAEAANQL 341 Query: 292 L------------SLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPI 339 L SLLE +++ T ++P ++ ++ +E FGP+L + Sbjct: 342 LKAQAAMLEKGATSLLEMKQL------KPDTGLLSPGIVDATG--IELEDQEFFGPLLTV 393 Query: 340 VPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPF 399 K DEA+ N L+ + S + KL R+++E +G V N + + ++ PF Sbjct: 394 YRYKGFDEALELANNTRYGLSAGILSDDRKLYNRLVEEVRAGIVNWNRPLTGAS-SAAPF 452 Query: 400 GGVGSSG 406 GGVG+SG Sbjct: 453 GGVGASG 459 >4DNG-A nrPDB Length = 485 Score = 119 bits (298), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 110/405 (27%), Positives = 186/405 (45%), Gaps = 30/405 (7%) Query: 23 RLQQLEALRRMVQEREKDILTAIAAD----LCKSEFNVYS-----QEVITVLGEIDFMLE 73 R L+ R + E DI+ IA + + KS + E +T GE+ + E Sbjct: 68 RKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTIELEQTIAILDEAMTYTGELGGVKE 127 Query: 74 NLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVI 133 +P + K K I PLGV+ I +N+P L+++ + AIA GN+V+ Sbjct: 128 -VPSDIEGKTNK-----------IYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVV 175 Query: 134 IKPS-ELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTE-LLKQRFDH-IFYTGNTAV 189 KP + + + I+AK L + V+ V+E + +L I +TG+TAV Sbjct: 176 HKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAV 235 Query: 190 GKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILC 249 G+ + E A + + LELGG +P + D D+D +GK+++ GQ C+ + I+ Sbjct: 236 GRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIV 295 Query: 250 EASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLEGQK---IAFGGE 305 + ++ V K VK+ YG+ +IN R ++ L ++E K I E Sbjct: 296 HQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVE 355 Query: 306 TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFS 365 + P V D +K+ Q E+F PI I+ + EAI+ N+ E L+ VF+ Sbjct: 356 GKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFT 415 Query: 366 HNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 + + ++ + SG ND ++ + N FGG +SG+G + Sbjct: 416 SDLEKGEKFALQIDSGMTHVNDQSVNDSPN-IAFGGNKASGVGRF 459 >1AG8-A nrPDB Length = 499 Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 92/347 (26%), Positives = 158/347 (45%), Gaps = 17/347 (4%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154 +Y + +P+GV I WN+P ++ L A+A GN V++K +E + TA +A L+ + Sbjct: 151 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 210 Query: 155 LDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGG 210 + + G T + D + +TG+T VG ++ AA K +L VTLE+GG Sbjct: 211 GFPPGVVNVIPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGG 270 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFY 269 KSP I D D+D + + + N GQ C A + + + V + + Sbjct: 271 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVV 330 Query: 270 GENIKESPDYERIINLRHFKRILSLLEGQK------IAFGGETDEATRYIAPTVLTDVDP 323 G + ++ FK++L ++ K + GG + +I PTV D+ Sbjct: 331 GNPFDSRTEQGPQVDETQFKKVLGYIKSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQD 390 Query: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV 383 + +EEIFGP++ I+ K+++E + N + LA VF+ + + +G V Sbjct: 391 GMTIAKEEIFGPVMQILKFKSMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTV 450 Query: 384 TGN--DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 N DV F S PFGG SG G G++ ++ + ++ Sbjct: 451 WVNCYDV---FGAQS-PFGGYKLSGSGRELGEYGLQAYTEVKTVTVR 493 >5IUV-A nrPDB Length = 497 Score = 118 bits (295), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 92/348 (26%), Positives = 161/348 (46%), Gaps = 26/348 (7%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQD 158 +P+GVV I WN+P ++ L A++ GN+V++KPSE S TA +A+L + + Sbjct: 156 EPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAG 215 Query: 159 LYIVINGGVEETTELLKQRF--DHIFYTGNTAVGKIVM-EAAAKHLTPVTLELGGKSPCY 215 + V+ G + L D + +TG+T + K +M A ++ V LE GGKSP Sbjct: 216 VLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNI 275 Query: 216 IDKDC-DLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENI 273 + D DL N G+ C A +L E S++++ + + E + + G + Sbjct: 276 VFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPL 335 Query: 274 KESPDYERIINLRHFKRILSLL-----EGQKIAFGGE---TDEATRYIAPTVLTDVDPKT 325 + + +++ + +LS + +G ++ GG+ + Y+ PT+ V+ Sbjct: 336 DPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAM 395 Query: 326 KVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGV-- 383 ++ QEEIFGP+L ++ +EAI N+ LA V++ N +G V Sbjct: 396 RIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWV 455 Query: 384 ---TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 G D+ + PFGG SG G H+FD ++ + +K Sbjct: 456 NQYDGGDM-------TAPFGGFKQSGNGRDKSLHAFDKYTELKSTWIK 496 >5X5U-A nrPDB Length = 505 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 99/426 (23%), Positives = 178/426 (41%), Gaps = 26/426 (6%) Query: 9 RQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEI 68 + F + R P R + +V+ER AIA + + + ++ + VL Sbjct: 80 QSGFEAWRKVPAHERAATMRKAAALVRERAD----AIAQLMTQEQGKPLTEARVEVLSAA 135 Query: 69 DFMLENLPEWVT--AKPVKKNVL---TMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLI 123 D + EW + V ++ + + + +P+G V WN+P ++ L Sbjct: 136 DII-----EWFADEGRRVYGRIVPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLS 190 Query: 124 GAIAAGNAVIIK-PSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQR--FDH 180 A+A G + ++K P E + A +L + + + ++ G E + L Sbjct: 191 AALATGCSFLVKAPEETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRK 250 Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240 + +TG+T VGK + A H+ T+ELGG +P + +D D+ + + K+ N GQ Sbjct: 251 VTFTGSTPVGKQLASLAGLHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQV 310 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE--- 296 CI+P L S++++ + + + G ++E + N R + S+++ Sbjct: 311 CISPTRFLVHNSIRDEFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNAR 370 Query: 297 --GQKIAFGGE-TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFIN 353 G I GGE + APTV+ +V V E FGP+ I ++EAI N Sbjct: 371 KVGASIETGGERIGSEGNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEAN 430 Query: 354 EREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGK 413 LA Y F+ + + + G + N + PFGGV SG G+ G Sbjct: 431 RLPFGLAGYAFTRSFANVHLLTQRLEVGMLWINQPATPWP--EMPFGGVKDSGYGSEGGP 488 Query: 414 HSFDTF 419 + + + Sbjct: 489 EALEPY 494 >1UXV-A nrPDB Length = 501 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 91/329 (27%), Positives = 153/329 (46%), Gaps = 15/329 (4%) Query: 90 TMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAK 149 T+ E ++ +PLGVV I +NYP + + + GNAV++KPS A + K Sbjct: 146 TLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSISDPLPAAMAVK 205 Query: 150 -LLPQYLDQDLYIVIN-GGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLE 207 LL D ++N G E + R + +TG+T VG+ V++ + +E Sbjct: 206 ALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTEVGERVVKVGG--VKQYVME 263 Query: 208 LGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE 267 LGG P + +D DLD+ +I G Y GQ C A +L E + ++V ++ + + Sbjct: 264 LGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKLVEEVAKRLSS 323 Query: 268 F-YGENIKESPDYERIINLRHFKRILSLLE-----GQKIAFGGETDEATRYIAPTVLTDV 321 G+ + D +I+ +++ +E G ++ GG T Y+ PT++ Sbjct: 324 LRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRRLGPT-YVQPTLVEAP 382 Query: 322 DPKTKVM---QEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDET 378 + K M + E+F P+ V VK++D+AI N R L VF + I+R + Sbjct: 383 ADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVFGRDVVKIRRAVRLL 442 Query: 379 SSGGVTGNDVIMHFTLNSFPFGGVGSSGM 407 G + ND+ H + +PFGG SG+ Sbjct: 443 EVGAIYINDMPRH-GIGYYPFGGRKKSGV 470 >5JRY-A nrPDB Length = 485 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 102/383 (26%), Positives = 178/383 (46%), Gaps = 34/383 (8%) Query: 54 FNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNY 113 F V S+E + + GE+ LE ++A+ Y + P+G I +N+ Sbjct: 117 FRVASEEAVRIDGEV-LNLE-----ISARAQGYT-------GYTRRVPIGPCSFISPFNF 163 Query: 114 PFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVI----NGGVE 168 P L + A+AAG ++KP+ + A I+ ++L + L + + V+ +G Sbjct: 164 PLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIGEVLAETDLPKGAFSVLPAHRDGADL 223 Query: 169 ETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC--DLDIVC 226 TT+ RF + +TG+ AVG + E A K V LELGG + +D D LD V Sbjct: 224 FTTD---DRFRLLSFTGSPAVGWALKEKAGKK--KVVLELGGNAAAIVDADQLDRLDYVV 278 Query: 227 RRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDY-ERIINL 285 R+ +G + GQ+CI IL A + + + K+ + + K+ + +I+ Sbjct: 279 DRLAFGAFYQSGQSCIGVQRILAHADIYDALRDKLIAKTRSLKMGDPKDPSTFVGPMISE 338 Query: 286 RHFKRILSLLE-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 +R+ ++ G KI GG+ D A T+L +V + ++E FGPI + Sbjct: 339 SESRRLSGWMDAAVAAGAKIVAGGKVDGAM--FEATLLENVGRDQDLYRKEAFGPIAILE 396 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFG 400 D+A+ +N+ + L VF+ + ++ DE GGV NDV F +++ P+G Sbjct: 397 KFDRFDDALARVNDSDFGLQAGVFTDSLAHTQQAWDELEVGGVVINDV-PSFRVDNMPYG 455 Query: 401 GVGSSGMGAYHGKHSFDTFSHQR 423 GV SG+G +++ + + R Sbjct: 456 GVKDSGLGREGIRYAIEDMTEPR 478 >4JZ6-A nrPDB Length = 500 Score = 111 bits (278), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 91/339 (26%), Positives = 154/339 (45%), Gaps = 24/339 (7%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 QP+G +L I WN VL + + + GN V+ K SE S T ++ + + + L Sbjct: 154 QPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAG 213 Query: 159 LYIVINGGVEETTELLK-----QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSP 213 + +N + + E+ + I +TG+T VG I+ + AA+HL LELGGKSP Sbjct: 214 VLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQKAAQHLKRCLLELGGKSP 273 Query: 214 CYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY---- 269 + D D++ + +G ++ GQ C++ + ++ + + ++ V + E + Sbjct: 274 LIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADEFVARFVEKTERLSVGDP 333 Query: 270 ---GENI---KESPDY-ERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVD 322 G+ I SP+ ERI L FK + +G K+ GG A + T+L V Sbjct: 334 CLTGDCIIGPMVSPNSGERINGL--FKDAID--KGAKVVCGGMAQGAV--MPATILDHVK 387 Query: 323 PKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGG 382 ++ EE FGPI ++ K EAI N+ L+ VF + R+ G Sbjct: 388 SDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRDINRALRVGMSIEYGC 447 Query: 383 VTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSH 421 V N + + P+GG ++G G + G+ D F+ Sbjct: 448 VHINGSTVQNEAQA-PYGGTKNTGYGRFDGRAVIDEFTE 485 >3VZ0-A nrPDB Length = 459 Score = 111 bits (277), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 105/413 (25%), Positives = 174/413 (42%), Gaps = 53/413 (12%) Query: 30 LRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLG--------EID-------FMLEN 74 LR + Q +E + + AADL + + ++ + T +G EID F Sbjct: 46 LRSIAQRKE---IVSRAADLLRRDRQHHASLIATEMGKALPDALEEIDVTADILSFYANG 102 Query: 75 LPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 E++ P+K +A I QPLG++ I WN+P+ + + AGN VI Sbjct: 103 AEEFLAPTPLK----VKTGQAKIINQPLGIIYCIEPWNFPYYQLARVAGPNLMAGNVVIA 158 Query: 135 KPSELSENTAKILAKLLPQ-----------YLDQDLYIVINGGVEETTELLK-QRFDHIF 182 K + A KL +LD D ++ EL+K +R + Sbjct: 159 KHAPNVPQCALAFEKLFHDAGAPVGAYANIFLDND----------QSAELIKDERIRGVA 208 Query: 183 YTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCI 242 TG+ G+ V A L T+ELGG + D DLD+ + WG++ N GQ C Sbjct: 209 LTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWAVWGRFANNGQVCT 268 Query: 243 APDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL-----SLLE 296 A ++ + + + +K + F G + + + +LR + L ++ Sbjct: 269 AAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRAMELALDQTAEAVKG 328 Query: 297 GQKIAFGGE-TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINER 355 G + GG+ D ++ PT+LTDV V +EIFGP+ + V + AI+ N+ Sbjct: 329 GATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKVASEQAAIDLANDS 388 Query: 356 EKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 L VFS + +++ ++ +G V N PFGG+ +SG G Sbjct: 389 PYGLGGAVFSRDIARAEKVAEQVETGMVFINTATA--AAPELPFGGIKNSGFG 439 >1T90-A nrPDB Length = 486 Score = 111 bits (277), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 99/381 (25%), Positives = 175/381 (45%), Gaps = 27/381 (7%) Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLD---------EAYIQPQPLGVVLIIGAWNYP 114 LGE+ +EN+ E+ P L M D EA P+GVV I +N+P Sbjct: 100 ALGEVGRGIENV-EFAAGAPS----LMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFP 154 Query: 115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTEL 173 ++ AIA GN I+KPSE + + L +L + L + ++ V+ G + + Sbjct: 155 MMVPCWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGI 214 Query: 174 LKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 L+ I + G+ VG+ V + +++L V G K+ + D +L+ I Sbjct: 215 LEHPEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGA 274 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI 291 + + G+ C+A + E + ++ + K++E V + G + + +I + KR Sbjct: 275 AFGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRT 334 Query: 292 LS-----LLEGQKIAFGGETD--EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKN 344 LS L EG ++ G + + ++ PT+ +V + + ++EIF P+L ++ VKN Sbjct: 335 LSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKN 394 Query: 345 VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGS 404 + EAI N+ E +F+ N I R E G+ G ++ + + FPF G S Sbjct: 395 LKEAIEIANKSEFANGACLFTSNSNAI-RYFRENIDAGMLGINLGVPAPMAFFPFSGWKS 453 Query: 405 SGMGAYH--GKHSFDTFSHQR 423 S G H GK S D ++ ++ Sbjct: 454 SFFGTLHANGKDSVDFYTRKK 474 >3JU8-A nrPDB Length = 490 Score = 111 bits (277), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 101/421 (23%), Positives = 190/421 (45%), Gaps = 25/421 (5%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ V R+AF + RPL R++ LE ++ R ++ I + K + + E Sbjct: 44 VDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWE-SATE 102 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V +++ ++ ++ E + +K+ A ++ +P GVV + G +N+P L Sbjct: 103 VTSMVNKVAISVQAFRE----RTGEKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNG 158 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR-F 178 ++ A+ AGN V+ KPSEL+ A++ K Q L + ++ GG E L R Sbjct: 159 HIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHRGL 218 Query: 179 DHIFYTGNTAVGKIV-MEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 D +F+TG++ G ++ + + + LE+GG +P +++ DLD I +++ Sbjct: 219 DGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISA 278 Query: 238 GQTC------IAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRI 291 GQ C + P +A L + V F + + +P +I+L + + Sbjct: 279 GQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRF---DEQPAPFMGAVISLSAAEHL 335 Query: 292 LSLLE------GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 L E Q + + + + P +L DV + EE FGP+L ++ + Sbjct: 336 LKAQEHLIGKGAQPLLAMTQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDF 394 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 AI N + LA + S + + ++ + E+ +G V N + +S PFGG+G+S Sbjct: 395 AAAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTG-AASSAPFGGIGAS 453 Query: 406 G 406 G Sbjct: 454 G 454 >3EK1-A nrPDB Length = 504 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 89/329 (27%), Positives = 151/329 (45%), Gaps = 12/329 (3%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 QP+GV I WN+P + + A+AAG +I++P++L+ TA L L + + Sbjct: 167 QPVGVTAAITPWNFPAAMITRKAAPALAAGCTMIVRPADLTPLTALALGVLAEKAGIPAG 226 Query: 159 LYIVINGGVEETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYI 216 + ++ G E L + +TG+T VG+++M A + ++LELGG +P + Sbjct: 227 VLQIVTGKAREIGAELTSNDTVRKLSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIV 286 Query: 217 DKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE 275 D DLD KY N GQTC+ + I + + ++ K+ VKE G + Sbjct: 287 FDDADLDAAVDGAMVSKYRNAGQTCVCANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEP 346 Query: 276 SPDYERIINLRHFKRILSLLE-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQE 330 +I + ++ + +E G K+ GG+ + + P +LT V V +E Sbjct: 347 GVVIGPMIEEKAITKVKAHIEDAVSKGAKLITGGK-ELGGLFFEPGILTGVTSDMLVAKE 405 Query: 331 EIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIM 390 E FGP+ P+ +E I N+ LA Y ++ N R+ + G V N ++ Sbjct: 406 ETFGPLAPLFAFDTEEEVIAQANDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLI 465 Query: 391 HFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 + PFGGV SG+G K+ + + Sbjct: 466 SNEVA--PFGGVKQSGLGREGSKYGIEEY 492 >4I3V-A nrPDB Length = 488 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 96/329 (29%), Positives = 156/329 (47%), Gaps = 24/329 (7%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 +PL + I +N+P + + AIA N V++KP+EL+ TA +LA +L + L + Sbjct: 149 EPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTPMTALLLADILYEAGLPPE 208 Query: 159 LYIVING-----GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSP 213 + V+ G G+E T D + +TG+ VGK++ AA H LELGG P Sbjct: 209 MLSVVTGWPADIGMEMIT---NPHVDLVTFTGSVPVGKLI--AANAHYKRQVLELGGNDP 263 Query: 214 CYIDKDCDLDIVCRR---ITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-Y 269 I D D + R G N GQ C A ILC+ S+ ++ V + E K + Sbjct: 264 LIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVADRFVPLVLERAKRLRF 323 Query: 270 GENIKESPD-----YERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPK 324 G+ + S D +E+ L + + + EG I + + + P V+ V + Sbjct: 324 GDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILY--HPGRSGALLPPIVVDRVPHQ 381 Query: 325 TKVMQEEIFGPILPIVPVKNVDEA-INFINEREKPLALYVFSHNHKLIKRMIDETSSGGV 383 + ++ EE FGPI+PIV V + D+A I N L+ V +++++ +++ I G V Sbjct: 382 SDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDYRRMQKYIAGLKVGTV 441 Query: 384 TGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 +V + + PFGG+ SG G G Sbjct: 442 NIWEV-PGYRIEMSPFGGIKDSGNGYKEG 469 >5J6B-A nrPDB Length = 485 Score = 108 bits (269), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 91/342 (26%), Positives = 162/342 (47%), Gaps = 21/342 (6%) Query: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154 Y + P+G I +N+P L + A+AAG ++KP+ + A I+ ++L + Sbjct: 145 GYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIGALIIGEVLAET 204 Query: 155 -LDQDLYIVI----NGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209 L + + ++ +G TT+ +RF + +TG+ VG + + A K V LELG Sbjct: 205 DLPKGAFSILPAHRDGADLFTTD---ERFKLLSFTGSPTVGWELKKKAGKKK--VVLELG 259 Query: 210 GKSPCYIDKDCD--LDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE 267 G + +D D LD V R+ +G Y GQ+CI I+ A + + + K+ + Sbjct: 260 GNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRIIAHADVYDALREKLIAKTRS 319 Query: 268 FYGENIKESPDY-ERIINLRHFKRILSLLE-----GQKIAFGGETDEATRYIAPTVLTDV 321 + K+ + +I+ +R+ +E G KI GG+ D A T+L V Sbjct: 320 LKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKIVAGGKVDGAM--FEATLLEGV 377 Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSG 381 + ++E FGP+ + + D+A+ +N+ + L VF+ + +R DE G Sbjct: 378 GRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGLQAGVFTDSLSHAQRAWDELEVG 437 Query: 382 GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 GV NDV F +++ P+GGV SG+G +++ + + R Sbjct: 438 GVVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELR 478 >5TJR-A nrPDB Length = 531 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 108/469 (23%), Positives = 206/469 (43%), Gaps = 37/469 (7%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 M+ + + AF + R+ P R Q L +++++ E+ I+ I+ + + + Sbjct: 75 MQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEANEERIVKLISEE--------HGKT 126 Query: 61 VITVLGEIDFMLENLPEWVTAKP------VKKNVLTMLDEAYIQPQPLGVVLIIGAWNYP 114 + GE+ +EN+ E+ TA P +NV +D A+ QP+GVV I +N+P Sbjct: 127 IEDAAGELKRGIENV-EYATAAPEILKGEYSRNVGPNID-AWSDFQPIGVVAGITPFNFP 184 Query: 115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTEL 173 ++ + AIA GN I+KPSE ++ ++A+L + L + + V++G L Sbjct: 185 AMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKGAVDAL 244 Query: 174 LKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 ++ + + G+T + + + K V G K+ + D DLD + Sbjct: 245 IEAPEVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGA 304 Query: 233 KYMNCGQTCIAPDYILCEAS-LQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKR 290 Y +CG+ C+A +C + + +V K+ +K G D ++ + Sbjct: 305 AYGSCGERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDK 364 Query: 291 ILSLLEGQKIAFGGE-----------TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPI 339 + ++ +A G E E ++ T+ V P+ + +EEIFGP+L I Sbjct: 365 VTGYID-TGVAQGAELVVDGRGYKVAGHENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCI 423 Query: 340 VPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPF 399 V V +++EA+ IN+ E +F+ + + + DE G+ G +V + + F Sbjct: 424 VRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEV-GMVGVNVPLPVPVAYHSF 482 Query: 400 GGVGSSGMGAYH--GKHSFDTFSHQRPCLLKSLKREG--ANKLRYPPNS 444 GG S G H G ++ ++ + +R+ A + +P NS Sbjct: 483 GGWKRSLFGDLHAYGPDGVRFYTKRKAITQRWPQRKSHEAAQFAFPSNS 531 >3R64-A nrPDB Length = 508 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 94/340 (27%), Positives = 164/340 (48%), Gaps = 29/340 (8%) Query: 103 GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYI- 161 GVV +I WN+P L+I+ + A+A GNAV+IKP+ + + ++P + ++ + Sbjct: 150 GVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPA----SDTPVTGGVIPARIFEEAGVP 205 Query: 162 --VINGGVEETTELLKQRFDH-----IFYTGNTAVGKIVMEAA--AKHLTPVTLELGGKS 212 VI+ +E+ H I +TG+T VG+ V E A + V LELGG + Sbjct: 206 AGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGNA 265 Query: 213 PCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGE 271 P + D D+D + G +++ GQ C++ + ++ +A++ ++ + K E VK G+ Sbjct: 266 PFVVLADADIDAAAQAAAVGAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTGD 325 Query: 272 NIKESPDYERIIN---LRHFKRILSLL--EGQKIAFGGETDEATRYIAPTVLTDVDPKTK 326 E +IN L K + L EG + G + R + P V +DV + Sbjct: 326 PSAEGTLVGPVINDSQLSGLKEKIELAKKEGATVQVEGPIE--GRLVHPHVFSDVTSDME 383 Query: 327 VMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386 + +EEIFGP++ ++ + A N + L+ V+S + + + SG V N Sbjct: 384 IAREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHIN 443 Query: 387 DVIMHFTLNSFP---FGGVGSSGMGAYHGKHSFDTFSHQR 423 D T+N P FGG +SG+G ++G + + F+ R Sbjct: 444 D----LTVNDEPHVMFGGSKNSGLGRFNGDWAIEEFTTDR 479 >4ZZ7-A nrPDB Length = 501 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 96/431 (22%), Positives = 192/431 (44%), Gaps = 31/431 (7%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E + + AF + R+ P L+ R M R K++L A ++C+ + + Sbjct: 45 VEQAISAAQHAFPTWRNTP------PLKRARVMF--RFKELLEQHADEICRLIGEEHGKI 96 Query: 61 VITVLGEIDFMLENLPEWVTAKPV------KKNVLTMLDEAYIQPQPLGVVLIIGAWNYP 114 +GE+ +EN+ E+ P +NV +D ++ + QP+GVV I +N+P Sbjct: 97 AHDAMGELQRGIENV-EYACGAPELLKGEHSRNVGPGID-SWSEFQPMGVVAGITPFNFP 154 Query: 115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTEL 173 ++ + AI GN ++KPSE ++ +A+LL + L + V+NG E L Sbjct: 155 VMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDAL 214 Query: 174 LK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 L R + + G+T + + + A+ + G K+ + D D+D ++ Sbjct: 215 LHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGA 274 Query: 233 KYMNCGQTCIAPDYILCEA-SLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKR 290 + + G+ C+A + + + +V K+ + +++ G + D+ +I +H ++ Sbjct: 275 AFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEK 334 Query: 291 ILSLL-----EGQKIAFGGE-----TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 ++ + +G I G E ++ T++ V P+ QEEIFGP+L +V Sbjct: 335 VIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVV 394 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFG 400 V + +A++ I+ E +F+ + + + D G+ G ++ + + FG Sbjct: 395 RVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQV-GMVGINIPLPVPVAYHSFG 453 Query: 401 GVGSSGMGAYH 411 G S G H Sbjct: 454 GWKRSLFGDLH 464 >3ROS-A nrPDB Length = 484 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 91/395 (23%), Positives = 166/395 (42%), Gaps = 16/395 (4%) Query: 23 RLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAK 82 R + L + ++E E ++ + ++ K + +EV + ++ ++ PE + K Sbjct: 50 RAEILHDIANALKEHEDELAKMMTLEMGKL-LSESKEEVELCVSICNYYADHGPEML--K 106 Query: 83 PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142 P K N + L AY Q GV++ WN+P I+ GN +++K + Sbjct: 107 PTKLN--SDLGNAYYLKQSTGVIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPG 164 Query: 143 TAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKH 200 +A + AK++ + + I + ++ +++ R + TG+ G V EAA K+ Sbjct: 165 SAALTAKIIKRAGAPEGSLINLYPSYDQLADIIADPRIQGVALTGSERGGSAVAEAAGKN 224 Query: 201 LTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWK 260 L T+ELGG + D D ++ + + N GQ C + I+ E S ++++ + Sbjct: 225 LKKSTMELGGNDAFIVLDDADPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHE 284 Query: 261 IKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG-------ETDEATRYI 313 +K + E+ +N K L + I G E D + Sbjct: 285 LKNVFSNLKAGDPLEADTTLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQYPEIDSKGAFF 344 Query: 314 APTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKR 373 PT+LTD+ V +E+FGPI + V++ + AI N+ L V + K+ Sbjct: 345 RPTILTDIAKDNPVFDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKK 404 Query: 374 MIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 + + +G N T PFGG+ SG G Sbjct: 405 VSAQIETGMTVING--RWITSGELPFGGIKKSGYG 437 >4OGD-A nrPDB Length = 465 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 93/417 (22%), Positives = 185/417 (44%), Gaps = 29/417 (6%) Query: 21 RFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVT 80 + +L Q+ + R +++ +I+T L F EV D+ + E++ Sbjct: 49 KAQLHQVANILRRDRDKYAEIMTKDMGKL----FTEAQGEVDLCADIADYYADKADEFLM 104 Query: 81 AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELS 140 + P++ T +AY Q GV+L + WN+P+ ++ GN +++K + + Sbjct: 105 STPLE----TDSGQAYYLKQSTGVILAVEPWNFPYYQIMRVFAPNFIVGNPMVLKHASIC 160 Query: 141 ENTAKILAKLLPQYLDQ-----DLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVME 195 +A+ +L+ + + +L+I + + + + +R + TG+ G + E Sbjct: 161 PRSAQSFEELVLEAGAEAGSITNLFISYD---QVSQVIADKRVVGVCLTGSERGGASIAE 217 Query: 196 AAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPD-YILCEASLQ 254 A K+L TLELGG I D D D + + + + + N GQ C + +I+ + Sbjct: 218 EAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNAGQVCTSSKRFIVLDKDYD 277 Query: 255 --NQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGET- 306 +++ K+ +T K +G+ + + + + +L +L G ++ +GGE Sbjct: 278 RFKELLTKVFKTAK--WGDPMDPETTLAPLSSAQAKADVLDQIKLALDHGAELVYGGEAI 335 Query: 307 DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSH 366 D ++ PT++ + + +EIFGP+ I V + +EAI N+ L +FS Sbjct: 336 DHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIEVANDSNYGLGGTIFSS 395 Query: 367 NHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 N + K + + +G N +L PFGG+ SG G + F +F ++ Sbjct: 396 NQEHAKAVAAKIETGMSFINSGWT--SLPELPFGGIKHSGYGRELSELGFTSFVNEH 450 >5N5S-A nrPDB Length = 515 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 94/387 (24%), Positives = 177/387 (45%), Gaps = 28/387 (7%) Query: 54 FNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNY 113 F V ++E + + GE ++P ++A+ K + + ++ P+G V ++ WN+ Sbjct: 144 FQVAAEESVRIYGE------HIPLDISAR--NKGL-----QGIVKKFPIGPVSMVSPWNF 190 Query: 114 PFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL--YIVINGGVEETT 171 P L + AIA G ++KP+ + +A IL ++L + + L + ++ E+ Sbjct: 191 PLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKIEELPLGAFSILPVSREDAD 250 Query: 172 EL-LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC-DLDIVCRRI 229 + +RF + +TG+ +G + A K V +ELGG +PC +D DLD +R+ Sbjct: 251 MFTVDERFKLLTFTGSGPIGWDMKARAGKK--KVVMELGGNAPCIVDDYVPDLDYTIQRL 308 Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHF 288 G + GQ+CI + L +++ VK+ G +E +I+ Sbjct: 309 INGGFYQGGQSCIHMQRLYVHERLYDEVKEGFVAAVKKLKMGNPFEEDTYLGPMISESAA 368 Query: 289 KRIL-----SLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVK 343 K I ++ +G K+ GG A +I PTV+ DV + +EEIFGP++ + Sbjct: 369 KGIEDWVKEAVAKGGKLLTGGNRKGA--FIEPTVIEDVPIEANARKEEIFGPVVLLYKYS 426 Query: 344 NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVG 403 + EA+ N L +F+ + + GGV ND ++S P+GG+ Sbjct: 427 DFKEAVKECNNTHYGLQSGIFTKDLNKAFYAFEHMEVGGVILNDSPA-LRVDSQPYGGLK 485 Query: 404 SSGMGAYHGKHSFDTFSHQRPCLLKSL 430 SG+ K++ D + +++++ Sbjct: 486 DSGIQREGVKYAMDDMLETKVLVMRNV 512 >2JG7-A nrPDB Length = 510 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 83/348 (23%), Positives = 158/348 (45%), Gaps = 14/348 (4%) Query: 98 QPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQ 157 Q P+G+V II A+N+P + A+ GN + K + + T+ + K++ + L+Q Sbjct: 152 QWNPVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQ 211 Query: 158 D-----LYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 + + + GG + T + K +R D + +TG+T VGK+V + LELGG Sbjct: 212 NNLPGAICSMTCGGADIGTAMAKDERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGN 271 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YG 270 + + +D DL++V + GQ C ++ S+ + +V +I + K+ G Sbjct: 272 NAIIVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIG 331 Query: 271 ENIKESPDYERIINLRHFKRILSLLE-----GQKIAFGGET-DEATRYIAPTVLTDVDPK 324 + S Y + + + L+ +E G + GG+ D Y+ PT++T + Sbjct: 332 DPWDPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMDRPGNYVEPTIITGLAHD 391 Query: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMID-ETSSGGV 383 ++ E F PIL ++ K +EA + NE ++ L+ +F+ + + R + + S G+ Sbjct: 392 APIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRVFRWLGPKGSDCGI 451 Query: 384 TGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431 ++ FGG +G G G S+ + + C + K Sbjct: 452 VNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTINYSK 499 >3RH9-A nrPDB Length = 506 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 101/406 (24%), Positives = 185/406 (45%), Gaps = 19/406 (4%) Query: 19 PLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEW 78 P+ R + LE +R ++E ++I + + K + EV G D+ +++ Sbjct: 69 PIETRRKWLEDIRDGLKENREEIGRILCMEHGKP-WKEAQGEVDYAAGFFDYCAKHISAL 127 Query: 79 VTAK-PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPS 137 + P K T + +P+GV +I WN+P + + L A+AAG +IKP+ Sbjct: 128 DSHTIPEKPKDCTWT----VHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPA 183 Query: 138 ELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVM 194 + T ++ + L + ++ G ++L + D + +TG+T VG+ ++ Sbjct: 184 SETPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHKDVPMLSFTGSTEVGRKLI 243 Query: 195 EAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQ 254 A+ + + LELGG +P + D DL+ + K+ GQTC+ + I + Sbjct: 244 VDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKVA 303 Query: 255 NQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE 308 + K+ E V + G+ + + D +IN + F ++ +L +G + G + E Sbjct: 304 DAFGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAGKQPAE 363 Query: 309 ATR--YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSH 366 + PTV+ VD + QEE FGP++P+ + +E I+ N+ E LA YVF+ Sbjct: 364 LGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVFTA 423 Query: 367 NHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 + + +R+ G V N PFGG+ +SG+G G Sbjct: 424 DAERAQRVAAGLRFGHVGWNTGTG--PTPEAPFGGMKASGIGREGG 467 >4KNA-A nrPDB Length = 495 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 93/421 (22%), Positives = 183/421 (43%), Gaps = 25/421 (5%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E V R+AF + + L R ++ ++ ER++ + T I + K + + E Sbjct: 48 VERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEART-E 106 Query: 61 VITVLGEIDFMLENLPEWVTAK--PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 V ++ ++D + E K P+ V A ++ +P GVV + G +N+P L Sbjct: 107 VASMAAKVDISITAYHERTGEKRAPMADGV------AVLRHRPHGVVAVFGPYNFPGHLP 160 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR 177 ++ A+ AGN V+ KPSEL+ A+ ++ L + ++ G + L R Sbjct: 161 NGHIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEKDTGVALANHR 220 Query: 178 -FDHIFYTGNTAVGKIVMEA-AAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 D +F+TG++ G ++ + + + LE+GG +P + + D+D ++ Sbjct: 221 QIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFL 280 Query: 236 NCGQTCIAPDYILC-EASLQNQIVWKIKETVKEFYGENIKESPD--YERIINLRHFKRIL 292 + GQ C IL + ++ V ++ + + P +I+ R R++ Sbjct: 281 SAGQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADPQPFMGAVISARAASRLV 340 Query: 293 SLLEGQKIAFGG-------ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 + + + + G + D A ++ +L DV ++ EE FGP+ IV ++ Sbjct: 341 A-AQARLVGLGASPIIEMKQRDPALGFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDL 398 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 D+AI N+ L+ + + + + +G V N + ++ PFGG G S Sbjct: 399 DDAIARANDTAFGLSAGLLADDEQAWHTFRRAIRAGIVNWNRPT-NGASSAAPFGGAGRS 457 Query: 406 G 406 G Sbjct: 458 G 458 >4X0T-A nrPDB Length = 513 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 85/351 (24%), Positives = 151/351 (43%), Gaps = 20/351 (5%) Query: 98 QPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIK----PSELSENTAKILAKLLP- 152 Q P+G+V II A+N+P + A+ GN + K S +S KI+AK+L Sbjct: 155 QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED 214 Query: 153 QYLDQDLYIVINGGVEETTELLK-QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 L + + GG + T + K +R + + +TG+T VGK V + LELGG Sbjct: 215 NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN 274 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271 + +D DL +V + GQ C + S+ +++V ++K+ + Sbjct: 275 NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQI--- 331 Query: 272 NIKESPDYERIINLRHFKRILSLL---------EGQKIAFGGET-DEATRYIAPTVLTDV 321 + D + H K+ +S+ EG + +GG+ D Y+ PT++T + Sbjct: 332 RVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGL 391 Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMID-ETSS 380 + E F PIL + KN +E + NE ++ L+ +F+ + I R + + S Sbjct: 392 GHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 451 Query: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK 431 G+ ++ FGG +G G G ++ + + C + K Sbjct: 452 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSK 502 >4PXN-A nrPDB Length = 525 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 77/343 (22%), Positives = 153/343 (44%), Gaps = 15/343 (4%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQD- 158 PLGVV +I A+N+P + A+ GN V+ K + + + K++ L+++ Sbjct: 170 NPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNN 229 Query: 159 ----LYIVINGGVEETTEL-LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSP 213 ++ GG E + L R + +TG+T G +V + + LEL G + Sbjct: 230 LPGAIFTSFCGGTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNA 289 Query: 214 CYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGEN 272 + D D+ + R + + GQ C ++ ++ + ++ E K+ G+ Sbjct: 290 IIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDP 349 Query: 273 IKES----PDYERIINLRHFKRILSL-LEGQKIAFGGETDEA-TRYIAPTVLTDVDPKTK 326 +++ P + K I ++ +G KI FGG E+ ++ PT++ ++ P Sbjct: 350 LEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGGSAIESEGNFVQPTIV-EITPSAP 408 Query: 327 VMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI-KRMIDETSSGGVTG 385 V++EE+FGP+L ++ + + EAI N + L+ +F+ +I K + S G+ Sbjct: 409 VVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDIIFKWLGPHGSDCGIVN 468 Query: 386 NDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 ++ + FGG ++G G G S+ + + C + Sbjct: 469 VNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTIN 511 >4E4G-A nrPDB Length = 521 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 82/333 (24%), Positives = 145/333 (43%), Gaps = 16/333 (4%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 QP+G+ I +N+P ++ + AIA GNA I+KPSE + LA+L+ + L Sbjct: 161 QPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSERDPSVPIRLAELMIEAGLPAG 220 Query: 159 LYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYID 217 + V+NG +L + + G+T + + V AA + G K+ I Sbjct: 221 ILNVVNGDKGAVDAILTHPDIAAVSFVGSTPIARYVYGTAAMNGKRAQCFGGAKNHMIIM 280 Query: 218 KDCDLDIVCRRITWGKYMNCGQTCIAPDY-ILCEASLQNQIVWKIKETVKEF-YGENIKE 275 D DLD + Y + G+ C+A + N+++ K+ V+ G E Sbjct: 281 PDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETANRLIDKLVPMVESLRIGPYTDE 340 Query: 276 SPDYERIINLRHFKRILSLLE-----GQKIAFGG-----ETDEATRYIAPTVLTDVDPKT 325 D ++ +RI SL++ G K+ G + E +I + DV P Sbjct: 341 KADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKLQGYENGHFIGGCLFDDVTPDM 400 Query: 326 KVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTG 385 + + EIFGP+L +V +N +EA++ + E + +++ + + + G+ G Sbjct: 401 DIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAIYTRDGDAARDFASRINI-GMVG 459 Query: 386 NDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDT 418 +V + L FGG SS G + +H D+ Sbjct: 460 VNVPIPVPLAYHSFGGWKSSSFGDLN-QHGTDS 491 >6DBB-A nrPDB Length = 511 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/342 (22%), Positives = 150/342 (43%), Gaps = 23/342 (6%) Query: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQ-- 157 P+GV +I A+N+P + A G++V+ KPSE + TA LL + L + Sbjct: 147 HPIGVCGVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFE 206 Query: 158 ---------DLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTL 206 +L ++ G + + E+L ++ + TG+ +G+ V + ++ L L Sbjct: 207 KTHPGVAPAELGQLVLG-MRDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGIL 265 Query: 207 ELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK 266 ELGG + + DLD+V R +T+ GQ C ++ SL Q++ +I++ Sbjct: 266 ELGGNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYA 325 Query: 267 EF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETD--EATRYIAPTVL 318 G ++E +++ F + L +G ++ G D A Y + Sbjct: 326 SVKVGNPLEEGTLVGPLVDRASFDAMQKALADAREQGGEVKGGERVDVGHADAYYVRPAI 385 Query: 319 TDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDET 378 + ++ V++ E F PIL ++ N D+AI+ N + L+ +F+++ + ++ + Sbjct: 386 VRMPKQSAVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMSAA 445 Query: 379 SSG-GVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 S G+ ++ FGG +G G G ++ + Sbjct: 446 GSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAY 487 >4LGZ-A nrPDB Length = 563 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 81/331 (24%), Positives = 138/331 (41%), Gaps = 32/331 (9%) Query: 103 GVVLIIGAWNYPFVLTIQPLIGAIA-AGNAVIIKPSELSENTAKILAKLL-----PQYLD 156 G V I +N F L GA A GN V+ KPS+ + + + ++L P + Sbjct: 202 GFVAAISPFN--FTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNII 259 Query: 157 QDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGG 210 Q ++ +G T + I +TG+ K + A++L + E GG Sbjct: 260 Q--FVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGG 317 Query: 211 KSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYG 270 K+ ++ D+D V + GQ C A + SL QI ++ E Sbjct: 318 KNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKV 377 Query: 271 ENIKE--SPDYERIINLRHFKRILSLLEGQK------IAFGGETDEAT-RYIAPTVLTDV 321 + E + +I+ + F RI LE + I GG+ +E+ Y+ P ++ Sbjct: 378 GDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESK 437 Query: 322 DPKTKVMQEEIFGPILP--IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIK---RMI 375 DP+ +M+EEIFGP+L + P E + ++ L VF+ + +++ RM+ Sbjct: 438 DPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRML 497 Query: 376 DETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 ++G ND + PFGG +SG Sbjct: 498 -RNAAGNFYINDKSTGSVVGQQPFGGARASG 527 >3V9H-A nrPDB Length = 566 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 79/327 (24%), Positives = 136/327 (41%), Gaps = 37/327 (11%) Query: 115 FVLTIQP---------LIGAIA-AGNAVIIKPSELSENTAKILAKLL-----PQYLDQDL 159 FV I P L GA A GN V+ KPS+ + + + ++L P + Q Sbjct: 206 FVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ-- 263 Query: 160 YIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAK-----HLTP-VTLELGGKSP 213 ++ +G + T + I +TG+ K + + A+ H P + E GGK+ Sbjct: 264 FVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNF 323 Query: 214 CYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENI 273 ++ + D++ V + GQ C A + SL QI ++ E + Sbjct: 324 HFVHRSADVESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDP 383 Query: 274 KE--SPDYERIINLRHFKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPK 324 E + +I+ + F RI LE + I GG+ D++ Y + P ++ DP+ Sbjct: 384 AEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQ 443 Query: 325 TKVMQEEIFGPILP--IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKRMID--ETS 379 +M+EEIFGP+L + P E + ++ L VFS + +++ + Sbjct: 444 EPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNA 503 Query: 380 SGGVTGNDVIMHFTLNSFPFGGVGSSG 406 +G ND + PFGG +SG Sbjct: 504 AGNFYINDKSTGSIVGQQPFGGARASG 530 >4OE4-A nrPDB Length = 580 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 101/405 (24%), Positives = 168/405 (41%), Gaps = 53/405 (13%) Query: 45 IAADLCKSEFNVYSQEVITVLGEIDFM---LENLPEWVTAKPVKKNVLTMLDEAYIQPQP 101 +AA + NVY E+ + DF ++ + +PV+ T Y +P Sbjct: 143 LAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKAEY---RP 199 Query: 102 L-GVVLIIGAWNYPFVLTIQPLIGAIA-AGNAVIIKPSELSENTAKILAKLLPQY-LDQD 158 L G V + +N F LIGA A GN V+ KPS+ + + +L +L + L + Sbjct: 200 LEGFVYAVSPFN--FTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGLPKG 257 Query: 159 LYIVINGGVEETTE--LLKQRFDHIFYTGNTAV-----GKI---VMEAAAKHLTPVTLEL 208 + I G + T+ L + F + +TG+T V GKI V+E + + E Sbjct: 258 VINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGET 317 Query: 209 GGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEAS------------LQNQ 256 GGK+ + ++ G + GQ C A + S LQ+Q Sbjct: 318 GGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQ 377 Query: 257 IVWKIKETVKEFYGENIKE--SPDYERIINLRHFKRILSLLEGQK------IAFGGETDE 308 V + + G N++ P +I+ + F +++ ++E K I +GG+ D+ Sbjct: 378 NVVPMNTSASPISGGNLRGFMGP----VIHEQSFDKLVKVIEDAKKDPELEILYGGQYDK 433 Query: 309 ATR-YIAPTVLTDVDPKTKVMQEEIFGPILPI--VPVKNVDEAINFI-NEREKPLALYVF 364 + ++ PTV+ P M E FGPIL + P +E + I N + L +F Sbjct: 434 SQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIF 493 Query: 365 SHNHKLIKRMIDET---SSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 + + K I+ DE S+G ND ++ FGG SG Sbjct: 494 AKDRKAIE-YADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSG 537 >5JFN-A nrPDB Length = 524 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 76/363 (20%), Positives = 146/363 (40%), Gaps = 60/363 (16%) Query: 97 IQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD 156 ++ P GV+ I P + IG +AAGN+V+ P + + +L +L+ Q L Sbjct: 183 VEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPRARQVSLLLVRLINQKLA 242 Query: 157 -----QDLYIVING-GVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209 ++L + + +E T ++ + + TG A+ K V+ K + Sbjct: 243 ALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATGGPAIVKAVLSTGKKAIG----AGA 298 Query: 210 GKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY 269 G P +D+ +++ I G + +A I+ A + + +++ +K+ Sbjct: 299 GNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIAVAQIADYLIFNLKKN----G 354 Query: 270 GENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVM- 328 IK+ +++ +L +L+ G + G++ ++ + VD K++ Sbjct: 355 AYEIKDPAVLQQLQDL-----VLTAKGGPQTKCVGKS---AVWLLSQIGISVDASIKIIL 406 Query: 329 ----------QEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHN---HKLIK--R 373 QEE+ PILP+V V+ VD+AI+ E E H+ KL K + Sbjct: 407 MEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIEVEHDNRHTAIMHSTDVRKLTKMAK 466 Query: 374 MIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG---------AYHGKHSFDTFSHQRP 424 +I T F N + G+G+ G G G S +F+ +R Sbjct: 467 LIQTTI------------FVKNGPSYAGLGAGGEGYSTFTIAGPTGEGLTSAKSFARRRK 514 Query: 425 CLL 427 C++ Sbjct: 515 CVM 517 >4IDS-A nrPDB Length = 563 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 96/409 (23%), Positives = 163/409 (39%), Gaps = 41/409 (10%) Query: 31 RRMVQEREKDILTA------IAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPV 84 R V R D+L AA + +VY E+ V IDF N+ + + Sbjct: 123 RAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVA--FARQIL 180 Query: 85 KKNVLTMLDE-AYIQPQPL-GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142 ++ ++ E I +PL G V I +N+ + P A+ GN VI KPS +++ Sbjct: 181 EQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPALM-GNTVIWKPS-ITQT 238 Query: 143 TAKIL-------AKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVME 195 A L A L P ++ + +G L R I +TG+TA + + Sbjct: 239 LAAYLTMQLLEAAGLPPGVIN---LVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQ 295 Query: 196 AAAK-----HLTP-VTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILC 249 H P + E GGK D++ + G + GQ C A Sbjct: 296 WVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFI 355 Query: 250 EASLQNQIVWKIKETVKEFYGENIKESPDYE-RIINLRHFKRILSLLEGQK------IAF 302 S+ ++ ++ E +I + +Y +I+ R F + + +E K +A Sbjct: 356 AHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAV 415 Query: 303 GGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP--IVPVKNVDEAINFINEREK-P 358 GGE D++ Y + PTVL DP + E FGP+L + P + ++ ++ I+ + Sbjct: 416 GGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYA 475 Query: 359 LALYVFSHNHKLIKRMIDET--SSGGVTGNDVIMHFTLNSFPFGGVGSS 405 L V + + + + +D ++G ND + PFGG S Sbjct: 476 LTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 >5UJU-A nrPDB Length = 576 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 82/334 (24%), Positives = 126/334 (37%), Gaps = 41/334 (12%) Query: 82 KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELS- 140 KP KN + + Y P G L++G +P L +A GN VI+KP + Sbjct: 186 KPQGKNPPLAMQKRYTI-VPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAI 244 Query: 141 ---ENTAKILAKLLPQY-LDQDLYIVI----NGGVEETTELLKQRFDHIFYTGNTAVGKI 192 T +I +L + D ++ ++ N G L+ I +TG+T G Sbjct: 245 LPLAITVRIARDVLREAGFDPNVVTLLATEPNDGALVQDLALRPEIKLIDFTGSTQNGTW 304 Query: 193 VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILC--- 249 + A H V E G + ID DL + I + + GQ C AP I Sbjct: 305 LERHA--HQAQVYTEKAGVNQIVIDSTDDLKAAAKNIAFSLALYSGQMCTAPQNIYVPRD 362 Query: 250 -------EASLQNQIVWKIKETVKEFYGE---------NIKESPDYERIINLRHFKRILS 293 AS +++ I V++ G+ I+ RI R R+ Sbjct: 363 GIRTADGHASF-DEVAQAIAGAVQKLTGDPARSVELIGAIQNDGVTARIDAARAVGRV-- 419 Query: 294 LLEGQKIAFGGETDEATRYIAPTVLT-DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFI 352 LL+ Q + D R P VL DV + K Q E FGPI ++ + ++++ Sbjct: 420 LLDSQTLQHPAFPDARVR--TPLVLQLDVADREKFTQ-EWFGPISFVIATDSTAQSLDLA 476 Query: 353 NE---REKPLALYVFSHNHKLIKRMIDETSSGGV 383 E L L V+S +I + GGV Sbjct: 477 GEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGV 510 >1EZ0-A nrPDB Length = 510 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 59/270 (21%), Positives = 108/270 (40%), Gaps = 29/270 (10%) Query: 102 LGVVLIIGAWNYPFVLTIQ--PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQD- 158 LG V + GA N+P + A+AAG VI+K T++I+A+ + Q L Q+ Sbjct: 137 LGPVAVFGASNFPLAFSAAGGDTASALAAGCPVIVKGHTAHPGTSQIVAECIEQALKQEQ 196 Query: 159 ----LYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTL--ELGG 210 ++ ++ G + L + +TG+ G+ + A + P+ ELG Sbjct: 197 LPQAIFTLLQGNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHERPEPIPFYGELGA 256 Query: 211 KSPCYI-----DKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETV 265 +P +I DL + M CGQ C P + + + Q + +++ Sbjct: 257 INPTFIFPSAMRAKADL---ADQFVASMTMGCGQFCTKPGVVFALNTPETQAFIETAQSL 313 Query: 266 KEFYGENIKESPDYERIINLR--HFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDP 323 ++SP +R + +++S I E+ + +T + Sbjct: 314 IR------QQSPSTLLTPGIRDSYQSQVVSRGSDDGIDVTFSQAESPCVASALFVTSSEN 367 Query: 324 --KTKVMQEEIFGPILPIVPVKNVDEAINF 351 K +EEIFGP IV +NV + ++ Sbjct: 368 WRKHPAWEEEIFGPQSLIVVCENVADMLSL 397 >3V4C-A nrPDB Length = 528 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/162 (24%), Positives = 70/162 (43%), Gaps = 20/162 (12%) Query: 100 QPLGVVLIIGAWNYPFVLTIQ--PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQ 157 +P+G V + GA N+P + A+AAG V++K T +I+A+ + + + Sbjct: 168 RPVGPVAVFGASNFPLAFSTAGGDTAAALAAGCPVVVKGHSAHPGTGEIVAEAVDAAIRK 227 Query: 158 -----DLYIVINGGVEETTELLKQ--RFDHIFYTGNTAVGKIVMEAAAKHLTPVTL--EL 208 ++ +I GG + L Q + +TG+ A G+ + + A P+ EL Sbjct: 228 TGVHPGVFSLIQGGSRDVGHALVQHPHIKAVGFTGSLAGGRALFDLCAARPEPIPFFGEL 287 Query: 209 GGKSPCYIDKDCDLDIVCRRITWGK------YMNCGQTCIAP 244 G +P ++ + + R T G+ M GQ C P Sbjct: 288 GSVNPMFLLPEA---LKARAETLGQGWAGSLTMGAGQFCTNP 326 >5J7I-A nrPDB Length = 488 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 42/184 (22%), Positives = 81/184 (44%), Gaps = 13/184 (7%) Query: 100 QPLGVVL-IIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQD 158 QP+G+V II + N + + LI A+ A NA++ P + A+++ + ++ Sbjct: 129 QPVGIVAGIIPSTNPTSTVIFKALI-AVKARNAIVFSPHPSAAKCTAEAARIMQEAAERA 187 Query: 159 ------LYIVINGGVEETTELLKQRF-DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGK 211 + + + T EL+K + D I TG G +++AA P G Sbjct: 188 GAPKGLISCITQPTMAATNELMKHKLTDVILATG----GPGLVKAAYSSGKPAYGVGPGN 243 Query: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271 P YI + ++ + I K + G C + +L + S++ ++V ++K+ F E Sbjct: 244 VPVYIHESANIAKAVQLIIQSKTFDYGTICASEQALLVDESIKEKVVAELKQQGAYFLNE 303 Query: 272 NIKE 275 K+ Sbjct: 304 EEKQ 307 >1O20-A nrPDB Length = 427 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 96/444 (21%), Positives = 174/444 (39%), Gaps = 71/444 (15%) Query: 6 RRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVL 65 ++VR+A+ R+ R + + ++ + + ER K+IL A D+ K+ + ++ L Sbjct: 21 KKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGVKESLVDRL 80 Query: 66 G----EIDFMLENLPEWVTAK-PVKKNVLTMLDEAYIQPQ----PLGVVLIIGAWNYPFV 116 ID M++ + K PV + + + + E ++ P+G + II + Sbjct: 81 ALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGII--YESRPN 138 Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL------DQDLYIVINGGVEET 170 +T++ I A+ +GN ++++ + N+ K + + + L + + + N Sbjct: 139 VTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSVEFIENTDRSLV 198 Query: 171 TELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG-GKSPCYIDKDCDLDIVCR 227 E+++ R + G + V + A PV LE G G ++D+ DL Sbjct: 199 LEMIRLREYLSLVIPRGGYGLISFVRDNAT---VPV-LETGVGNCHIFVDESADLKKAVP 254 Query: 228 RITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRH 287 I K G TC A + +L + + + I E +++ +G ++ Sbjct: 255 VIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELRK-HGVEVRGC----------- 301 Query: 288 FKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKV-MQEEIFGPILPIVPVKNVD 346 E TR I P DV P T+ E I+ I VKNVD Sbjct: 302 --------------------EKTREIVP----DVVPATEDDWPTEYLDLIIAIKVVKNVD 337 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 EAI I + + + + N+ K+ + E + V N S F G G Sbjct: 338 EAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVN--------ASTRFTDGGQFG 389 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSL 430 GA G S F + P L+ L Sbjct: 390 FGAEIG-ISTQRFHARGPVGLREL 412 >1VLU-A nrPDB Length = 468 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 46/165 (27%), Positives = 73/165 (44%), Gaps = 20/165 (12%) Query: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENT----AKILAKLL 151 Y P+GV+L+I + I L +I +GNA I+K + S NT AKI+ + Sbjct: 121 YQVTAPVGVLLVIFESRPEVIANITAL--SIKSGNAAILKGGKESVNTFREMAKIVNDTI 178 Query: 152 PQYLDQDLYIVINGGV------EETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTP 203 Q+ Q V G V ++ ++LL Q D + G+ A+ + + + P Sbjct: 179 AQF--QSETGVPVGSVQLIETRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDTTK---IP 233 Query: 204 VTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYIL 248 V G Y+D+D DL I +RI+ N C A + +L Sbjct: 234 VLGHADGICSIYLDEDADL-IKAKRISLDAKTNYPAGCNAMETLL 277 >1O6C-A nrPDB Length = 388 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 38/150 (25%), Positives = 60/150 (40%), Gaps = 19/150 (12%) Query: 69 DFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI-----QPLI 123 DF L + E T + N L LDE + +P +VL+ G F ++ Q + Sbjct: 58 DFDLNIMKERQTLAEITSNALVRLDELFKDIKP-DIVLVHGDTTTTFAGSLAAFYHQIAV 116 Query: 124 GAIAAG----NAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFD 179 G + AG N P EL+ +A DL+ G ++ ++ D Sbjct: 117 GHVEAGLRTGNKYSPFPEELNRQMTGAIA---------DLHFAPTGQAKDNLLKENKKAD 167 Query: 180 HIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209 IF TGNTA+ + + PV ++G Sbjct: 168 SIFVTGNTAIDALNTTVRDGYSHPVLDQVG 197 >6D97-A nrPDB Length = 547 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 56/270 (20%), Positives = 105/270 (38%), Gaps = 54/270 (20%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD---- 156 P G V II +N+P + + L+GA+ GN ++K + + ++ +++ D Sbjct: 188 PYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLK---VDSKVSIVMEQMIRLLHDCGLP 244 Query: 157 -QDLYIVINGGVEETTELLKQRFDHIFYTGNTAV---------GKIVMEAAA---KHLTP 203 +D+ + + G LL+ +TG++ V G++ +E A K L P Sbjct: 245 AEDMDFINSDGAVMNKLLLEANPKMTLFTGSSRVAEKLAADLKGRVKLEDAGFDWKILGP 304 Query: 204 VTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQ-IVWKIK 262 E+ Y+ CD D Y GQ C A + + + ++ K+K Sbjct: 305 DVQEVD-----YVAWVCDQD---------AYACSGQKCSAQSVLFMHKNWSSSGLLEKMK 350 Query: 263 ETVKEFYGENIKESPDYERIIN--LRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTD 320 + + E++ P + H +L + G K+ FGGE + P + Sbjct: 351 KLSERRKLEDLTIGPVLTVTTEAMIEHMNNLLK-IRGSKVLFGGEP--LANHSIPKIYGA 407 Query: 321 VDPKT--------------KVMQEEIFGPI 336 + P +++ +EIFGP Sbjct: 408 MKPTAVFVPLEEILKSGNFELVTKEIFGPF 437 >3K9D-A nrPDB Length = 464 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 33/176 (18%), Positives = 69/176 (39%), Gaps = 7/176 (3%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLY 160 PLGVV + P I + +I AGN+++ P + +++ + ++ Sbjct: 108 PLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEK--A 165 Query: 161 IVINGGVEETTELLKQRFDHIFYTGNTAV-----GKIVMEAAAKHLTPVTLELGGKSPCY 215 G + T Q D + +TAV G +++AA TP G P + Sbjct: 166 GCPKGAISCMTVPTIQGTDQLMKHKDTAVILATGGSAMVKAAYSSGTPAIGVGPGNGPAF 225 Query: 216 IDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGE 271 I++ ++ + I K + G C + ++ E + ++ + ++ F + Sbjct: 226 IERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSD 281 >4GHK-A nrPDB Length = 444 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 34/120 (28%), Positives = 46/120 (38%), Gaps = 14/120 (11%) Query: 321 VDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSS 380 VD + + E P+L I V +D AI INE + + +H R + E S Sbjct: 329 VDATDEDWRTEYLAPVLAIKIVDGIDAAIEHINEYGSHHTDAIVTEDHDRAMRFLREVDS 388 Query: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRY 440 V N F + F F G+GA G S D + P L EG L+Y Sbjct: 389 ASVMVN-ASTRFA-DGFEF------GLGAEIGI-SNDKLHARGPVGL-----EGLTSLKY 434 >3RLI-A nrPDB Length = 270 Score = 31.6 bits (70), Expect = 0.83, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 57/149 (38%), Gaps = 29/149 (19%) Query: 88 VLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKIL 147 VL+ + Y + P+GV+L+ G P +++PL A A + P T Sbjct: 27 VLSGAEPFYAENGPVGVLLVHGFTGTPH--SMRPLAEAYAKAGYTVCLPRLKGHGT---- 80 Query: 148 AKLLPQYLDQDLYIVIN--GGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKH----- 200 Y D + + VEE LKQR IF TG + G + + A H Sbjct: 81 -----HYEDMERTTFHDWVASVEEGYGWLKQRCQTIFVTGLSMGGTLTLYLAEHHPDICG 135 Query: 201 LTPVTLEL-----------GGKSPCYIDK 218 + P+ + GG+ P Y+D Sbjct: 136 IVPINAAVDIPAIAAGMTGGGELPRYLDS 164 >5DBV-A nrPDB Length = 445 Score = 31.2 bits (69), Expect = 0.94, Method: Compositional matrix adjust. Identities = 70/354 (19%), Positives = 134/354 (37%), Gaps = 43/354 (12%) Query: 97 IQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YL 155 ++ P GV+ I P I IG +A GN V+ P + T+ +L+ + L Sbjct: 105 VEMGPFGVIGAITPCTNPSETIICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASL 164 Query: 156 DQDLYIVINGGVEETT------ELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209 + I V + T + Q I TG V V+++ + + Sbjct: 165 SAGGPVNIACSVRKPTLDSSKIMMSHQDIPLIAATGGPGVVTAVLQSGKRGIGAG----A 220 Query: 210 GKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV-WKIKETVKEF 268 G P +D+ D+ I G + IA ++ ++ N+++ + +KE Sbjct: 221 GNPPVLVDETADIRKAAEDIINGCTFDNNLPAIAEKEVVAIDAIANELMNYMVKE----- 275 Query: 269 YGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDV------- 321 G E++ NL + L+ + G + I V +++ Sbjct: 276 QGCYAITKEQQEKLTNLVITPKGLN-----RNCVGKDARTLLGMIGIDVPSNIRCIIFEG 330 Query: 322 DPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLAL-YVFSHNHKLIKRMIDETSS 380 + + ++ EE+ PIL IV K+ D+A+ EK + L + H+ + + +D ++ Sbjct: 331 EKEHPLISEELMMPILGIVRAKSFDDAV------EKAVWLEHGNRHSAHIHSKNVDRITT 384 Query: 381 GGVTGNDVIMHFTLNSFPFGGVGSSGMGAY-------HGKHSFDTFSHQRPCLL 427 + I+ S+ G G G + G S TF+ +R C++ Sbjct: 385 YAKAIDTAILVKNAPSYAAIGFGGEGFCTFTIASRTGEGLTSASTFTKRRRCVM 438 >6G4F-A nrPDB Length = 464 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 30/135 (22%), Positives = 56/135 (41%), Gaps = 18/135 (13%) Query: 84 VKKNVLTMLDEAYIQPQPLGVVLI--------------IGAWNYPFVLTIQPLIGAIAAG 129 ++ +++ + + QP+ +LI +GA + F + P+ A+A Sbjct: 278 IQPDIMVLSKQLSSSYQPIAAILINAPVFEGIADQSQALGALGHGFTGSGHPVATAVALE 337 Query: 130 NAVIIKPSELSENTA---KILAKLLPQYLDQDLYIVING-GVEETTELLKQRFDHIFYTG 185 N II+ L E+ A ++L L ++D L I G G+ EL+ R Y Sbjct: 338 NLKIIEEESLVEHAAQMGQLLRSGLQHFIDHPLVGEIRGCGLIAAVELVGDRVSKAPYQA 397 Query: 186 NTAVGKIVMEAAAKH 200 +G+ + A +H Sbjct: 398 LGTLGRYMAGRAQEH 412 >2H5G-A nrPDB Length = 463 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 23/145 (15%) Query: 101 PLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLY 160 P+GV+L+I + + L AIA+GN +++K + + ++ +IL L + L Sbjct: 140 PIGVLLVIFESRPDCLPQVAAL--AIASGNGLLLKGGKEAAHSNRILHLLTQEALSIH-- 195 Query: 161 IVINGGVEETTELLKQR------------FDHIFYTGNTAVGKIVMEAAAKHLTPVTLEL 208 GV+E +L+ R D I G++ + + + +AA PV Sbjct: 196 -----GVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKG--IPVMGHS 248 Query: 209 GGKSPCYIDKDCDLDIVCRRITWGK 233 G Y+D + +D V R + K Sbjct: 249 EGICHMYVDSEASVDKVTRLVRDSK 273 >6FYQ-A nrPDB Length = 484 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 45/205 (21%), Positives = 79/205 (38%), Gaps = 37/205 (18%) Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLI---------- 107 + EVIT G M + W V +V+T PLG V++ Sbjct: 279 ADEVITGFGRTGKMF-GIENW----DVIPDVMTFAKGVTSGYFPLGGVVVSDPIHEVLKE 333 Query: 108 --IGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVING 165 +G + F + P A+A N IIK L EN+ ++ LL Sbjct: 334 KSVGTLFHGFTYSGHPTAAAVALKNIAIIKEERLVENSKRMGDALLH------------- 380 Query: 166 GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIV 225 G+++ L+ D + + G +++ A L++ +P I+ +L ++ Sbjct: 381 GLKKVKNRLEIVGD-VRFVGLLGAVELMQNPATNKPFSSNLQV---APKVIEALHELGVI 436 Query: 226 CRRITWGKYMNCGQTCIAPDYILCE 250 CR +T Y + C+AP I+ + Sbjct: 437 CRSVT---YDHTNIICLAPPLIINQ 458 >3JC8-Qa nrPDB Length = 901 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 22/36 (61%) Query: 324 KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPL 359 +TK + +E FG I+ I P+K ++E ER+K L Sbjct: 534 RTKALGKEEFGNIIRIAPLKTLEEEARLRQERKKSL 569 >5TY0-A nrPDB Length = 422 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 5/46 (10%) Query: 33 MVQEREKDILTAIAADLC-----KSEFNVYSQEVITVLGEIDFMLE 73 MVQE+E+ I AA C +F + +I G +DFM+E Sbjct: 54 MVQEQERGITITSAATTCYWSGMDKQFESHRINIIDTPGHVDFMIE 99 >3MCP-A nrPDB Length = 366 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 28/192 (14%) Query: 199 KHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258 K+L VTL G + ID + ++ G Y+ C + P+YI+ E S+ + V Sbjct: 148 KNLLGVTLGTGFGAGVVIDGE----LLRGDNAAGGYVWCLRNKKYPEYIV-EESVSIRAV 202 Query: 259 WKI---------KETVKEFY--GENIKESPDYERIINLRHFKRI--------LSLLEGQK 299 ++ T KE + E I+ I + ++L++G Sbjct: 203 MRVYAERSGDAGARTPKEIFEIAEGIRPGNREAAIAAFEELGEMAGDALASAITLIDGL- 261 Query: 300 IAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFIN-EREKP 358 I GG A++YI P +L +++ +T +M FG + V ++DE +F R + Sbjct: 262 IVIGGGLSGASKYILPVLLKEMNAQTGMMDGARFGRLQK--EVYDLDEEKSFAGFARGEA 319 Query: 359 LALYVFSHNHKL 370 + + V N K+ Sbjct: 320 VEVLVPGTNRKV 331 >5AGA-A nrPDB Length = 830 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 30/75 (40%), Gaps = 1/75 (1%) Query: 401 GVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKR-F 459 G+ + + YH F Q CLL EG N + P S K + +LKR Sbjct: 11 GLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVL 70 Query: 460 NKEKLGLLLLTFLGI 474 K L +L F+ + Sbjct: 71 EMRKKALFILPFVSV 85 >6MFV-A nrPDB Length = 653 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 6/55 (10%) Query: 344 NVDEAINFINEREKPLA------LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHF 392 N +EA + E+EK + LY + H L+ +I E+S TG D + +F Sbjct: 165 NPEEAYSLAREKEKSMTPEEFAKLYKLTFGHPLMLNLILESSEILATGKDTVFNF 219 >6GB2-BC nrPDB Length = 657 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 23/118 (19%), Positives = 44/118 (37%), Gaps = 33/118 (27%) Query: 134 IKPSELSENTAKILAKLLPQYLDQDLYIVIN--------------------GGVEETTEL 173 +KP E E + +L+ ++ +D + ++N G V Sbjct: 433 LKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDVSANDVN 492 Query: 174 LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTL-------------ELGGKSPCYIDK 218 L + FD + Y N G ++ ++AAK + L EL + PC +++ Sbjct: 493 LAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYRLVEDLQEELSSRLPCAVEE 550 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4QGK-A nrPDB 599 e-172 3SZA-A nrPDB 535 e-152 1AD3-A nrPDB 521 e-148 5AC2-A nrPDB 519 e-147 5AC0-A nrPDB 518 e-147 4X2Q-A nrPDB 503 e-143 5FHZ-A nrPDB 502 e-142 5L13-A nrPDB 498 e-141 1AG8-A nrPDB 492 e-139 4V3F-A nrPDB 490 e-139 1O9J-A nrPDB 489 e-138 5GT6-A nrPDB 488 e-138 6QAO-A nrPDB 481 e-136 4O6R-A nrPDB 475 e-134 4I8P-A nrPDB 473 e-134 1BPW-A nrPDB 473 e-134 4PZ2-A nrPDB 472 e-133 3IWK-A nrPDB 470 e-133 4CAZ-A nrPDB 466 e-131 4MPY-A nrPDB 465 e-131 3IWJ-A nrPDB 463 e-131 3R31-A nrPDB 462 e-130 4PXL-B nrPDB 460 e-130 4GO4-A nrPDB 460 e-130 3JZ4-A nrPDB 459 e-129 4O5H-A nrPDB 451 e-127 4I8Q-A nrPDB 447 e-126 6C43-A nrPDB 447 e-126 6B4R-B nrPDB 446 e-126 3I44-A nrPDB 446 e-125 2D4E-A nrPDB 445 e-125 3RHO-A nrPDB 445 e-125 3TY7-A nrPDB 439 e-123 5IUV-A nrPDB 437 e-123 4F3X-A nrPDB 437 e-123 1WNB-A nrPDB 434 e-122 5KLK-A nrPDB 432 e-121 3B4W-A nrPDB 430 e-121 4QYJ-A nrPDB 429 e-120 4V6H-A nrPDB 429 e-120 3K2W-A nrPDB 423 e-118 4LIH-A nrPDB 421 e-118 5TJR-A nrPDB 417 e-117 2HG2-A nrPDB 417 e-117 3RHD-A nrPDB 416 e-117 5NNO-A nrPDB 415 e-116 3RJL-A nrPDB 415 e-116 5UR2-A nrPDB 414 e-116 5UCD-A nrPDB 414 e-116 4ZZ7-A nrPDB 413 e-116 5EUY-A nrPDB 413 e-116 3QAN-A nrPDB 413 e-116 3EK1-A nrPDB 405 e-113 3U4J-A nrPDB 404 e-113 4U3W-A nrPDB 402 e-112 5J77-A nrPDB 398 e-111 1T90-A nrPDB 398 e-111 2JG7-A nrPDB 398 e-111 2W8P-A nrPDB 396 e-111 3EFV-A nrPDB 395 e-110 4OGD-A nrPDB 394 e-110 5X5U-A nrPDB 393 e-110 4DNG-A nrPDB 393 e-110 6MVR-A nrPDB 393 e-109 3VZ0-A nrPDB 393 e-109 3VZ3-A nrPDB 393 e-109 3ROS-A nrPDB 392 e-109 3RH9-A nrPDB 389 e-108 2QE0-A nrPDB 389 e-108 5N5S-A nrPDB 388 e-108 4JZ6-A nrPDB 387 e-108 4YWE-A nrPDB 386 e-108 4X0T-A nrPDB 385 e-107 5KF0-A nrPDB 383 e-106 3PRL-A nrPDB 382 e-106 5VBF-A nrPDB 381 e-106 6FK3-A nrPDB 378 e-105 5JRY-A nrPDB 377 e-105 2J5N-A nrPDB 376 e-104 5U0M-A nrPDB 374 e-104 4H7N-A nrPDB 370 e-103 4PXN-A nrPDB 369 e-102 5J6B-A nrPDB 367 e-102 4E4G-A nrPDB 367 e-102 3R64-A nrPDB 366 e-101 3JU8-A nrPDB 364 e-101 4KNA-A nrPDB 363 e-100 6DBB-A nrPDB 347 7e-96 4I3V-A nrPDB 346 9e-96 1UXV-A nrPDB 339 1e-93 4LGZ-A nrPDB 326 2e-89 3V9H-A nrPDB 324 4e-89 4OE4-A nrPDB 312 2e-85 4IDS-A nrPDB 291 4e-79 1EZ0-A nrPDB 192 4e-49 3V4C-A nrPDB 189 2e-48 5JFN-A nrPDB 181 7e-46 5UJU-A nrPDB 176 2e-44 5J7I-A nrPDB 150 9e-37 Sequences not found previously or not previously below threshold: 5DBV-A nrPDB 177 8e-45 2Y53-A nrPDB 148 7e-36 6D97-A nrPDB 128 5e-30 3MY7-A nrPDB 127 9e-30 3K9D-A nrPDB 114 6e-26 1O20-A nrPDB 109 3e-24 4GHK-A nrPDB 85 6e-17 4JBE-A nrPDB 81 1e-15 2H5G-A nrPDB 70 2e-12 1VLU-A nrPDB 64 1e-10 1PDZ-A nrPDB 35 0.072 5MMM-i nrPDB 31 1.0 2XH7-A nrPDB 31 1.3 5X8R-i nrPDB 31 1.3 6C49-A nrPDB 31 1.5 4G1B-A nrPDB 29 3.3 3LOO-A nrPDB 29 3.7 2R70-A nrPDB 29 4.3 1EU1-A nrPDB 29 5.2 2Y5N-A nrPDB 29 5.5 5W7R-A nrPDB 29 6.2 2IPH-A nrPDB 29 6.6 3C3E-A nrPDB 28 6.7 5A0V-A nrPDB 28 6.8 1WQS-A nrPDB 28 7.9 5JN2-A nrPDB 28 10.0 >4QGK-A nrPDB Length = 461 Score = 599 bits (1546), Expect = e-172, Method: Composition-based stats. Identities = 460/460 (100%), Positives = 460/460 (100%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE Sbjct: 2 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 61 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ Sbjct: 62 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 121 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH Sbjct: 122 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 181 Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT Sbjct: 182 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 241 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI Sbjct: 242 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 301 Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA Sbjct: 302 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 361 Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS Sbjct: 362 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 421 Query: 421 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFN 460 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFN Sbjct: 422 HQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFN 461 >3SZA-A nrPDB Length = 469 Score = 535 bits (1378), Expect = e-152, Method: Composition-based stats. Identities = 298/443 (67%), Positives = 378/443 (85%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +E Sbjct: 20 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 79 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V+ VL EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQ Sbjct: 80 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 139 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDH 180 P++GAIAAGNAV++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDH Sbjct: 140 PMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDH 199 Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240 I YTG+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQT Sbjct: 200 ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQT 259 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKI 300 C+APDYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+ Sbjct: 260 CVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKV 319 Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360 A+GG D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLA Sbjct: 320 AYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLA 379 Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFS 420 LY+FS N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFS Sbjct: 380 LYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFS 439 Query: 421 HQRPCLLKSLKREGANKLRYPPN 443 H+R CL++ L + K+RYPP+ Sbjct: 440 HRRSCLVRPLMNDEGLKVRYPPS 462 >1AD3-A nrPDB Length = 452 Score = 521 bits (1342), Expect = e-148, Method: Composition-based stats. Identities = 290/439 (66%), Positives = 368/439 (83%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 V+R R+AF SG++R L+FR+QQLEAL+RM+ E K I A+A+DL K+E+ Y +EV V Sbjct: 7 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 66 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 L E+D ++ LP+W +PV K T D+ YI +PLGVVL+IGAWNYPF LTIQP++G Sbjct: 67 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 126 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184 A+AAGNAVI+KPSE+S + A +LA L+PQY+DQ+LY+V+ GGV ETTELLK+RFDHI YT Sbjct: 127 AVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIMYT 186 Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244 G+TAVGKIVM AAAKHLTPVTLELGGKSPCY+DKDCDLD+ CRRI WGK+MN GQTC+AP Sbjct: 187 GSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAP 246 Query: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304 DYILC+ S+QNQIV K+K+++K+FYGE+ K+S DY RIIN RHF+R+ L++ QK+A GG Sbjct: 247 DYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGG 306 Query: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 D+++RYIAPT+L DVDP++ VMQEEIFGP++PIV V++++EAI FIN+REKPLALYVF Sbjct: 307 TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 366 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424 S+N K+IK+MI ETSSGGVT NDVI+H T+ + PFGGVG+SGMGAYHGK SF+TFSH+R Sbjct: 367 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRS 426 Query: 425 CLLKSLKREGANKLRYPPN 443 CL+KSL E A+K RYPP+ Sbjct: 427 CLVKSLLNEEAHKARYPPS 445 >5AC2-A nrPDB Length = 501 Score = 519 bits (1337), Expect = e-147, Method: Composition-based stats. Identities = 118/448 (26%), Positives = 198/448 (44%), Gaps = 20/448 (4%) Query: 1 MELEVRRVRQAFLS---GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V+ RQAF R+ R + L L +++ + T + + K +Y Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGK----LY 115 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 S + L L W + + Y + +P+GV I WN+P V+ Sbjct: 116 SNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-- 174 I + A++ GN V++KP+E + TA +A L+ + + ++ G + Sbjct: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 D + +TG+T VGK++ EAA K +L VTLELGGKSPC + D DLD G Sbjct: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYGENIKESPDYERIINLRHFKRIL 292 + + GQ CIA I E S+ ++ V + E K+ G + I+ + +IL Sbjct: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355 Query: 293 SLLE-----GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 L+E G K+ GG ++ PTV ++V + ++ +EEIFGP+ I+ K++D Sbjct: 356 DLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD 415 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 + I N L+ VF+ + + +G V N PFGG SG Sbjct: 416 DVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSG 473 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREG 434 G G++ F ++ + +K ++ Sbjct: 474 NGRELGEYGFHEYTEVKTVTVKISQKNS 501 >5AC0-A nrPDB Length = 501 Score = 518 bits (1335), Expect = e-147, Method: Composition-based stats. Identities = 117/448 (26%), Positives = 199/448 (44%), Gaps = 20/448 (4%) Query: 1 MELEVRRVRQAFLS---GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V+ RQAF R+ R + L L +++ + T A + K N Y Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAY 119 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 + LG L W + + Y + +P+GV I WN+P ++ Sbjct: 120 LMD----LGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLM 175 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-- 174 + + A++ GN V++KP+E + TA + L+ + + ++ G + Sbjct: 176 FLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 D + +TG+T VGK++ EAA K +L V+LELGGKSPC + D DLD G Sbjct: 236 HMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGV 295 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRIL 292 + + GQ CIA + E S+ ++ V + E K++ G + I+ +++IL Sbjct: 296 FYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKIL 355 Query: 293 SLLE-----GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 L+E G K+ GG +I PTV +DV ++ +EEIFGP+ I+ K++D Sbjct: 356 DLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLD 415 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 + I N L+ +F+++ + SG V N PFGG SG Sbjct: 416 DVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVN--CYSVVSAQCPFGGFKMSG 473 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREG 434 G G++ F ++ + +K ++ Sbjct: 474 NGRELGEYGFHEYTEVKTVTIKISQKNS 501 >4X2Q-A nrPDB Length = 504 Score = 503 bits (1295), Expect = e-143, Method: Composition-based stats. Identities = 113/448 (25%), Positives = 191/448 (42%), Gaps = 20/448 (4%) Query: 1 MELEVRRVRQAFL---SGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V+ R AF R R + L+ L +V+ + T + + K + Sbjct: 63 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 122 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 ++ V+ + W + + + +P+GV I WN+P ++ Sbjct: 123 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 178 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 176 + A+ GN V+IKP+E + +A + L+ + + ++ G + Sbjct: 179 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIAS 238 Query: 177 RF--DHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 D I +TG+T VGK++ EAA + +L VTLELGGKSP I D DLD + G Sbjct: 239 HIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGV 298 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYGENIKESPDYERIINLRHFKRIL 292 + N GQ C A I E S+ + V + E K G + + I+ + + +IL Sbjct: 299 FFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKIL 358 Query: 293 SLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 L+ EG K+ GG+ +I PTV ++V ++ +EEIFGP+ I+ K +D Sbjct: 359 ELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMD 418 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 E I N + L VF+++ + +G V N + PFGG SG Sbjct: 419 EVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN--CYNALNAQSPFGGFKMSG 476 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREG 434 G G+ +S + +K ++ Sbjct: 477 NGREMGEFGLREYSEVKTVTVKIPQKNS 504 >5FHZ-A nrPDB Length = 529 Score = 502 bits (1294), Expect = e-142, Method: Composition-based stats. Identities = 114/442 (25%), Positives = 194/442 (43%), Gaps = 20/442 (4%) Query: 1 MELEVRRVRQAFLS---GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V + AF R R + L L +V+ + D K + + Sbjct: 88 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 147 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 + L L W K + + +P+GV I WN+P ++ Sbjct: 148 FID----LEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 203 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-- 174 + L A+ GN +++KP+E + TA L L+ + + ++ G + Sbjct: 204 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 263 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 + + I +TG+T VGK+V EAA++ +L VTLELGGK+PC + D DLD+ G Sbjct: 264 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 323 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL 292 + N GQ C A + E + ++ V + E K+ G+ + I+ + F +IL Sbjct: 324 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 383 Query: 293 SLLE-----GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 L+E G K+ GG ++ +I PTV ++V ++ +EEIFGP+ PI+ K+++ Sbjct: 384 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 443 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 E I N + L VF+ N ++ SG V N + PFGG SG Sbjct: 444 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 501 Query: 407 MGAYHGKHSFDTFSHQRPCLLK 428 G G+++ ++ + +K Sbjct: 502 NGRELGEYALAEYTEVKTVTIK 523 >5L13-A nrPDB Length = 517 Score = 498 bits (1283), Expect = e-141, Method: Composition-based stats. Identities = 107/448 (23%), Positives = 186/448 (41%), Gaps = 20/448 (4%) Query: 1 MELEVRRVRQAFLS---GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V+ R AF R R + L L +++ + D K Y Sbjct: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 ++ VL + + W K + +Y + +P+GV I WN+P ++ Sbjct: 136 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-- 174 L A+A GN V++K +E + TA +A L+ + + ++ G + Sbjct: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 + D + +TG+T +G+++ AA +L VTLELGGKSP I D D+D + + Sbjct: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYGENIKESPDYERIINLRHFKRIL 292 + N GQ C A + + ++ V + K G + ++ FK+IL Sbjct: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371 Query: 293 SLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 + EG K+ GG + +I PTV DV + +EEIFGP++ I+ K ++ Sbjct: 372 GYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIE 431 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 E + N LA VF+ + + +G V N + PFGG SG Sbjct: 432 EVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGA--QSPFGGYKMSG 489 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREG 434 G G++ ++ + +K ++ Sbjct: 490 SGRELGEYGLQAYTEVKTVTVKVPQKNS 517 >1AG8-A nrPDB Length = 499 Score = 492 bits (1268), Expect = e-139, Method: Composition-based stats. Identities = 107/448 (23%), Positives = 187/448 (41%), Gaps = 20/448 (4%) Query: 1 MELEVRRVRQAFLS---GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V+ R AF R R + L L +++ + D K Y Sbjct: 58 VDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYIISY 117 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 ++ VL + + W K + +Y + +P+GV I WN+P ++ Sbjct: 118 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFPLLM 173 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-- 174 L A+A GN V++K +E + TA +A L+ + + VI G + Sbjct: 174 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAAIAS 233 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 + D + +TG+T VG ++ AA K +L VTLE+GGKSP I D D+D + + Sbjct: 234 HEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHFAL 293 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYGENIKESPDYERIINLRHFKRIL 292 + N GQ C A + + + V + K G + ++ FK++L Sbjct: 294 FFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKVL 353 Query: 293 SLL-----EGQKIAFGGETD-EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 + EG K+ GG + +I PTV D+ + +EEIFGP++ I+ K+++ Sbjct: 354 GYIKSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKSME 413 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 E + N + LA VF+ + + +G V N + PFGG SG Sbjct: 414 EVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGA--QSPFGGYKLSG 471 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREG 434 G G++ ++ + ++ ++ Sbjct: 472 SGRELGEYGLQAYTEVKTVTVRVPQKNS 499 >4V3F-A nrPDB Length = 497 Score = 490 bits (1263), Expect = e-139, Method: Composition-based stats. Identities = 116/440 (26%), Positives = 199/440 (45%), Gaps = 17/440 (3%) Query: 1 MELEVRRVRQAF--LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 +E+ V R+AF + + R L A+ + E++ + D K F+ Sbjct: 47 VEVAVVAARRAFRRNNWSATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKP-FDEAV 105 Query: 59 QEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 ++ V ++ + + ++++ QPLGVV +I WNYP ++ Sbjct: 106 LDIDDVASCFEYFAGQAEALDGKQKAPVTLPMERFKSHVLRQPLGVVGLISPWNYPLLMA 165 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL--K 175 + A+AAG ++KPSEL+ T ++ + L + ++ G + L Sbjct: 166 TWKIAPALAAGCTAVLKPSELASVTCLEFGEVCNEVGLPPGVLNILTGLGPDAGAPLVSH 225 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 D I +TG++A G VM +AA+ + PVTLELGGKSP + +D D+D V +G + Sbjct: 226 PDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCFW 285 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSL 294 GQ C A +L S+ + V K+ + K + +E +I+ + +I+ Sbjct: 286 TNGQICSATSRLLVHESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIMKF 345 Query: 295 L-----EGQKIAFGGETDE---ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 + EG I +GG E YI PT++TD+ ++ +EE+FGP+L + + D Sbjct: 346 ISTAKSEGATILYGGSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSED 405 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 EAI N+ E LA VFS++ + +R+ G V N F P+GG+ SG Sbjct: 406 EAIALANDTEYGLAAAVFSNDLERCERITKALEVGAVWVNCSQPCFV--QAPWGGIKRSG 463 Query: 407 MGAYHGKHSFDTFSHQRPCL 426 G G+ + + + Sbjct: 464 FGRELGEWGIQNYLNIKQVT 483 >1O9J-A nrPDB Length = 501 Score = 489 bits (1259), Expect = e-138, Method: Composition-based stats. Identities = 112/448 (25%), Positives = 198/448 (44%), Gaps = 20/448 (4%) Query: 1 MELEVRRVRQAFLS---GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 ++ V+ R+AF R+ R Q + L +++ + T + + K + Y Sbjct: 60 VDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAY 119 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117 ++ + + + W + + +Y + +P+GV +I WN P +L Sbjct: 120 LMDLDYCIKALRYCAG----WADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMIL 175 Query: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-- 174 + A+ GN VI+KP+E + TA +A L+ + + ++ G + Sbjct: 176 LACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 D + +TG+T VGK++ EAAAK +L VTLELG K+PC + D DLD G Sbjct: 236 HMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGV 295 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRIL 292 + N GQ+CIA + E ++ ++ V + E K++ G + ++ IN +I+ Sbjct: 296 FTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIM 355 Query: 293 SLLE-----GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 L+E G K+ GG +I PTV ++V ++ +EEIFGP+ I+ K++D Sbjct: 356 ELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLD 415 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 E I N L VF+ + + +G V N + P GG SG Sbjct: 416 EVIKRANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVNCYL--AASAQSPAGGFKMSG 473 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREG 434 G G++ ++ + +K ++ Sbjct: 474 HGREMGEYGIHEYTEVKTVTMKISEKNS 501 >5GT6-A nrPDB Length = 508 Score = 488 bits (1257), Expect = e-138, Method: Composition-based stats. Identities = 107/440 (24%), Positives = 195/440 (44%), Gaps = 18/440 (4%) Query: 1 MELEVRRVRQAFLS--GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 ++ V+ R AF S R + L +++E +++ A D K Sbjct: 73 IDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALD 132 Query: 59 QEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 ++ + + W T + ++ Y + +P+GVV I WN+P V++ Sbjct: 133 DDISATVENYRYYAG----WTTKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLVMS 188 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--K 175 + A+A G +++KP+E + + AKL + + + G E + Sbjct: 189 SWKMGAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAIVNH 248 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 D + +TG+T GK +M +A+ + VTLELGGKSP I +D DL+ G Sbjct: 249 HDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNIILEDADLEEAINGAFQGIMY 308 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSL 294 N GQ C A + +V + + G +++ + +++ + +R+L+ Sbjct: 309 NHGQNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERVLNY 368 Query: 295 L-----EGQKIAFGGETD-EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 + EG +A GGE E ++ PTV TDV +++EEIFGP++ ++P + +E Sbjct: 369 IEQGKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEEV 428 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 I N LA V++ N K ++ ++ +G V ND + + PFGG SG+G Sbjct: 429 IERANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWIND--YNLENAAAPFGGYKQSGIG 486 Query: 409 AYHGKHSFDTFSHQRPCLLK 428 G ++ D ++ + + Sbjct: 487 RELGSYALDNYTEVKSVWVN 506 >6QAO-A nrPDB Length = 508 Score = 481 bits (1238), Expect = e-136, Method: Composition-based stats. Identities = 114/450 (25%), Positives = 201/450 (44%), Gaps = 22/450 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + L V+ + AF + R + L R+++ERE +I T + KS F + Sbjct: 65 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-D 123 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + +++ L Y + +PLGV + IGAWNYPF + Sbjct: 124 IDISWQCLEYYAGLAASMAGEHIQ----LPGGSFGYTRREPLGVCVGIGAWNYPFQIASW 179 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-KQRF 178 A+A GNA++ KPS + +A +LA++ + + L+ V+ GG L Sbjct: 180 KSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDV 239 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + ++ G Sbjct: 240 AKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQG 299 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-- 295 Q C + + + ++ ++ + + G+ + E +IN H +R+L + Sbjct: 300 QVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKV 359 Query: 296 ---EGQKIAFGGETD-------EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 +G K+ GG+ + Y+ P VLT+ ++EEIFGP++ I+ Sbjct: 360 AKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTE 419 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 E + N+ LA VF+ + + R++ E +G N+ + + PFGG S Sbjct: 420 AEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYKKS 477 Query: 406 GMGAYHGKHSFDTFSHQRPCLLKSLKREGA 435 G G +G+ + + +S + ++ E A Sbjct: 478 GFGRENGRVTIEYYSQLKTVCVEMGDVESA 507 >4O6R-A nrPDB Length = 496 Score = 475 bits (1222), Expect = e-134, Method: Composition-based stats. Identities = 102/443 (23%), Positives = 187/443 (42%), Gaps = 22/443 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++L V +AF + + P R + L L ++ + + + D + + + Sbjct: 50 VDLAVDAATRAFPAWSAMPAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRALD 109 Query: 61 VITVLGEIDFMLENLPEWVTA-KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI 119 V + + + PV L Y+Q P+GVV I WN+P + T Sbjct: 110 VPRTAACFRYFGGMADKLQGSVIPVDTGFLN-----YVQRAPIGVVGQIVPWNFPLMFTS 164 Query: 120 QPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELLKQR- 177 + A+AAGN V++KPSE++ + + +L+ + + ++ G + L + Sbjct: 165 WKMGPALAAGNTVVLKPSEITPLSTLRIVELMAEVGFPAGVVNIVPGYGHTAGQRLAEHP 224 Query: 178 -FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 236 I +TG+TA G+ ++EA+ +L V LELGGK + D +LD W + N Sbjct: 225 GVGKIAFTGSTATGRRIVEASQGNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHN 284 Query: 237 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL 295 GQ CIA ++ + + + + G + + + + + +H R+LS + Sbjct: 285 QGQACIAGSRLVLHERIADAFLERFVALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYV 344 Query: 296 E-----GQKIAFGGETDE-----ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 + G ++ GG + Y+ PT++ +V QEE+FGP + ++ + Sbjct: 345 DVAREQGGRVLTGGSAPQDPALANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSD 404 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 DEA+ N E L +++++ RM +G N PFGGVG S Sbjct: 405 DEALAIANATEYGLGSGLWTNDLSRAHRMAARIDAGMCWIN--CYKRVNPGSPFGGVGKS 462 Query: 406 GMGAYHGKHSFDTFSHQRPCLLK 428 G G G + ++ R + Sbjct: 463 GYGREMGFEAMHDYTEARSVWVN 485 >4I8P-A nrPDB Length = 520 Score = 473 bits (1219), Expect = e-134, Method: Composition-based stats. Identities = 105/425 (24%), Positives = 190/425 (44%), Gaps = 15/425 (3%) Query: 14 SGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLE 73 P R + L A+ V ER+ ++ A D K ++ + ++ V G ++ + Sbjct: 82 DWARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKP-YDEAAWDMDDVAGCFEYFAD 140 Query: 74 NLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVI 133 + ++ + +++ +P+GVV +I WNYP ++ + A+AAG + Sbjct: 141 QAEALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAV 200 Query: 134 IKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVG 190 +KPSEL+ T LA + + L + ++ G + L D + +TG+ G Sbjct: 201 LKPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETG 260 Query: 191 KIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCE 250 K +M +AA + PVTLELGGKSP + D D+D +G + GQ C A +L Sbjct: 261 KKIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIH 320 Query: 251 ASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGG 304 + + ++ K + ++E +++ +++I + +G I GG Sbjct: 321 TKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGG 380 Query: 305 ETD---EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLAL 361 E +I PT++TD+ ++ +EE+FGP+L + DEAI N+ + LA Sbjct: 381 VRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAG 440 Query: 362 YVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSH 421 V S + + +R+ +E +G + N F P+GG SG G G+ D + Sbjct: 441 AVISGDRERCQRLSEEIDAGCIWVNCSQPCFC--QAPWGGNKRSGFGRELGEGGIDNYLS 498 Query: 422 QRPCL 426 + Sbjct: 499 VKQVT 503 >1BPW-A nrPDB Length = 503 Score = 473 bits (1217), Expect = e-134, Method: Composition-based stats. Identities = 111/443 (25%), Positives = 196/443 (44%), Gaps = 22/443 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ V+ + A+L R + + R+++ER +I + K + Sbjct: 60 VDQAVQSAQAAYLKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGK-TITEAEYD 118 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + I++ P ++ + ++ L AY + +PLGV I AWNYPF++ Sbjct: 119 IDAAWQCIEYYAGLAPT-LSGQHIQ---LPGGAFAYTRREPLGVCAGILAWNYPFMIAAW 174 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ-RF 178 A+A GNAV+ KPS ++ T ILA++ + + L V+ GG E + L Sbjct: 175 KCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAGVPVGLVNVVQGGAETGSLLCHHPNV 234 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 + +TG+ GK VME +AK + VTLELGGKSP I KDC+L+ R ++ G Sbjct: 235 AKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQG 294 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-- 295 Q C + + + Q + ++ + K G+ + +I+ ++L + Sbjct: 295 QVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGFVAQ 354 Query: 296 ---EGQKIAFGGETDEA-------TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 EG ++ GGE +++P VL + ++EEIFGP++ ++P Sbjct: 355 AKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTE 414 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 +E + N LA VF+ + R+ +G N + PFGG S Sbjct: 415 EEVLQRANNTTFGLASGVFTRDISRAHRVAANLEAGTCYIN--TYSISPVEVPFGGYKMS 472 Query: 406 GMGAYHGKHSFDTFSHQRPCLLK 428 G G +G+ + D +S + +++ Sbjct: 473 GFGRENGQATVDYYSQLKTVIVE 495 >4PZ2-A nrPDB Length = 534 Score = 472 bits (1215), Expect = e-133, Method: Composition-based stats. Identities = 110/442 (24%), Positives = 198/442 (44%), Gaps = 22/442 (4%) Query: 1 MELEVRRVRQAFLS--GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 ++L VR R AF R + + L +V+E ++ + D K + Sbjct: 90 VDLAVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRA 149 Query: 59 QEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 +V G + + + + + + + +PLGV +I WN+P + Sbjct: 150 VDVGNAAGSLRYFAGAADKI----HGETLKMPGQFQGHTLREPLGVAGVIIPWNFPSTMF 205 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--K 175 + A+AAG A+++KP+E + +A LA+L Q + + V+ G L Sbjct: 206 AVKVAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALASH 265 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 D + +TG+T VG+++M+A+A+ +L PV LELGGKSP + D DLD+ + Sbjct: 266 MDVDMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASF 325 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENI--KESPDYERIINLRHFKRIL 292 N G+ C+A + + + ++ ++ E ++ + + D ++ ++R+L Sbjct: 326 FNKGEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYERVL 385 Query: 293 SLL-----EGQKIAFGGET---DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKN 344 S + EG + GG + YI PTV T+V + +EEIFGP++ ++ K Sbjct: 386 SYIDHGKREGATLLTGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKT 445 Query: 345 VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGS 404 V+EAI N+ L V + + + R++ +G V N + PFGG Sbjct: 446 VEEAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVN--CYFAMGSDCPFGGRKM 503 Query: 405 SGMGAYHGKHSFDTFSHQRPCL 426 SG G G H+ D + + + Sbjct: 504 SGFGKDEGMHALDKYLAVKSVV 525 >3IWK-A nrPDB Length = 503 Score = 470 bits (1210), Expect = e-133, Method: Composition-based stats. Identities = 113/443 (25%), Positives = 206/443 (46%), Gaps = 20/443 (4%) Query: 1 MELEVRRVRQAFLS-----GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFN 55 ++L V ++A + R + L A+ ++E++ ++ + D K Sbjct: 47 VDLAVDAAKRAISRKNGRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPL-E 105 Query: 56 VYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPF 115 ++ V+ ++ E + + ++ ++YI +P+GVV +I WNYPF Sbjct: 106 EALADLDDVVACFEYYAGLAEELDSKQKAPISLPMDTFKSYILKEPIGVVALITPWNYPF 165 Query: 116 VLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL 174 ++ + A+AAG A I+KPSEL+ T L ++ + L + + ++ G E L Sbjct: 166 LMATWKIAPALAAGCAAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEAGASL 225 Query: 175 --KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 D I +TG++A G +M AA+ + PV+LELGGKSP + +D DLD V +G Sbjct: 226 ASHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEWTVFG 285 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI 291 + GQ C A ++ S+ + V K+ + + + ++E I++ +K++ Sbjct: 286 CFFTNGQICSATSRLIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQYKKV 345 Query: 292 LSLL-----EGQKIAFGGETDE---ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVK 343 L+ + EG I GG E ++ PT++TDV ++ +EE+FGP+L + Sbjct: 346 LNCISSAKSEGATILTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFS 405 Query: 344 NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVG 403 +EAIN N+ L V S++ + +R+ +G V N F P+GG+ Sbjct: 406 TEEEAINLANDTHYGLGSAVMSNDLERCERLSKALQAGIVWINCAQPSFI--QAPWGGIK 463 Query: 404 SSGMGAYHGKHSFDTFSHQRPCL 426 SG G G+ + + + Sbjct: 464 RSGFGRELGEWGLENYLSVKQVT 486 >4CAZ-A nrPDB Length = 490 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 119/443 (26%), Positives = 200/443 (45%), Gaps = 21/443 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E V+ + + R + L +++ER ++ D K S + Sbjct: 46 VERAVQSAVEGQKVWAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVD 105 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 ++T +++ +P A ++ L Y + +PLGVV IGAWNYP + + Sbjct: 106 IVTGADVLEYYAGLVP----AIEGEQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIALW 161 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR-- 177 A+AAGNA+I KPSE++ TA LA++ + + ++ V+ G E + L + Sbjct: 162 KSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPL 221 Query: 178 FDHIFYTGNTAVGKIVMEAAAKH-LTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 236 + I +TG T+ GK VM +A+ L VT+ELGGKSP I D DLD + + Sbjct: 222 IEKISFTGGTSTGKKVMASASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFS 281 Query: 237 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL 295 GQ C + S Q + K+ E V+ G+ E+ ++ +++ H + +L + Sbjct: 282 SGQVCTNGTRVFIHRSQQARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYI 341 Query: 296 EG-----QKIAFGGETD-----EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 E ++ GGE Y+APTV TD +++EEIFGP++ I+ + Sbjct: 342 ESGKAQKARLLCGGERVTDGAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDE 401 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 DEAI N+ E LA V + + R I +G N + P GG S Sbjct: 402 DEAIRRANDTEYGLAAGVVTQDLARAHRAIHRLEAGICWINTW--GESPAEMPVGGYKQS 459 Query: 406 GMGAYHGKHSFDTFSHQRPCLLK 428 G+G +G + ++ + ++ Sbjct: 460 GVGRENGLTTLAHYTRIKSVQVE 482 >4MPY-A nrPDB Length = 520 Score = 465 bits (1197), Expect = e-131, Method: Composition-based stats. Identities = 110/444 (24%), Positives = 202/444 (45%), Gaps = 22/444 (4%) Query: 2 ELEVRRVRQAFLS--GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQ 59 E + R+AF S R +++ A+ ++E + + D K+ Sbjct: 73 ERAILAARRAFESGEWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTL-EESYA 131 Query: 60 EVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI 119 ++ + + L + + + + E+ I +P+GVV I WNYP + Sbjct: 132 DMDDIHNVFMYFA-GLADKDGGEMIDSPIP--DTESKIVKEPVGVVTQITPWNYPLLQAS 188 Query: 120 QPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL--KQ 176 + A+A G ++++KPSE++ T + +L+ + + +I G E +++ + Sbjct: 189 WKIAPALATGCSLVMKPSEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHK 248 Query: 177 RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 236 D + +TG GK +M+ AA ++T + LELGGK+P I D D ++ + G Y + Sbjct: 249 EVDLVSFTGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFH 308 Query: 237 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL 295 GQ C A IL + S++++ + + VK+ G + +I+ H +I S + Sbjct: 309 AGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIESYM 368 Query: 296 -----EGQKIAFGGETDEA-----TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 EG IA GG+ + + PTV+T+ D +++QEE+FGP++ + + Sbjct: 369 DVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETE 428 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 EAI N+ LA VFS + +R+ ++ G V ND +F P+GG S Sbjct: 429 QEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWINDFHPYFA--QAPWGGYKQS 486 Query: 406 GMGAYHGKHSFDTFSHQRPCLLKS 429 G+G GK + + + L + Sbjct: 487 GIGRELGKEGLEEYLVSKHILTNT 510 >3IWJ-A nrPDB Length = 503 Score = 463 bits (1193), Expect = e-131, Method: Composition-based stats. Identities = 111/443 (25%), Positives = 204/443 (46%), Gaps = 20/443 (4%) Query: 1 MELEVRRVRQAF-----LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFN 55 +++ V + A + R + L A+ V E++ ++ + D K Sbjct: 47 VDVAVAAAKTALTRNKGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDE 106 Query: 56 VYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPF 115 + ++ V G ++ + + + ++ ++++ +P+GVV +I WNYP Sbjct: 107 -AAWDIDDVAGCFEYYADLAEKLDARQKAPVSLPMDTFKSHVLREPIGVVGLITPWNYPM 165 Query: 116 VLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL 174 ++ + A+AAG A I+KPSEL+ T L ++ + L + ++ G E L Sbjct: 166 LMATWKVAPALAAGCAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEAGAPL 225 Query: 175 --KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 D + +TG++A G +M AAA+ + PV+LELGGKSP + +D DLD +G Sbjct: 226 ATHPDVDKVAFTGSSATGSKIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFG 285 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI 291 + GQ C A ++ S+ + + +I + +K + ++E +++ +++I Sbjct: 286 CFWTNGQICSATSRLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKI 345 Query: 292 LSLL-----EGQKIAFGGETDE---ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVK 343 L + EG I GG E +I PT++TDV ++ +EE+FGP+L + Sbjct: 346 LKFVSNAKSEGATILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFS 405 Query: 344 NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVG 403 +EAI+ N+ L V S++ + +R+ +G V N FT P+GGV Sbjct: 406 TEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAGIVWVNCSQPCFT--QAPWGGVK 463 Query: 404 SSGMGAYHGKHSFDTFSHQRPCL 426 SG G G+ D + + Sbjct: 464 RSGFGRELGEWGLDNYLSVKQVT 486 >3R31-A nrPDB Length = 517 Score = 462 bits (1189), Expect = e-130, Method: Composition-based stats. Identities = 108/443 (24%), Positives = 189/443 (42%), Gaps = 18/443 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E + ++A + R + L+ +++ER + T D K + Sbjct: 54 VERAIASAKRAQKEWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVAD 113 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + +F P + + D AY + PLGV + IGAWNYP + Sbjct: 114 PTSGADAFEFFGGIAPSALNG----DYIPLGGDFAYTKRVPLGVCVGIGAWNYPQQIACW 169 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ-RF 178 A+ AGNA++ KPSE + A +A++L + L + L+ VI G + L+ Sbjct: 170 KAAPALVAGNAMVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGDRDTGPLLVNHPDV 229 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 + TG+ G+ V AAA HL VT+ELGGKSP + D D++ G + + G Sbjct: 230 AKVSLTGSVPTGRKVAAAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSG 289 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRILSLL-- 295 Q C + + + + + +K + G+ + + +++ +++LS + Sbjct: 290 QVCSNGTRVFVQKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEK 349 Query: 296 ---EGQKIAFGGETD----EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 EG + GG Y+ PTV DV + +EEIFGP++ ++ + DE Sbjct: 350 GKAEGATLITGGGIPNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEV 409 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 + N E LA VF+ + R++D +G + N + PFGG SG G Sbjct: 410 LARANATEFGLAGGVFTADLARAHRVVDGLEAGTLWIN--TYNLCPVEIPFGGSKQSGFG 467 Query: 409 AYHGKHSFDTFSHQRPCLLKSLK 431 + + + +S + + + K Sbjct: 468 RENSAAALEHYSELKTVYVSTGK 490 >4PXL-B nrPDB Length = 517 Score = 460 bits (1185), Expect = e-130, Method: Composition-based stats. Identities = 110/439 (25%), Positives = 190/439 (43%), Gaps = 19/439 (4%) Query: 1 MELEVRRVRQAFLS--GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 ++L V+ R+AF + R + L ++ E +++ D K + Sbjct: 76 VDLAVKAAREAFDNGPWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVGKA 135 Query: 59 QEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 +++ + + + A + Y +P+GVV I WNYP + Sbjct: 136 RDIPGAAHLLRYYAGAADKVHGAT----LKMAQRMHGYTLKEPVGVVGHIVPWNYPTTMF 191 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTEL--LK 175 + A+AAG AV++KP+E + +A A L + + + V+ G Sbjct: 192 FFKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAAVAAH 251 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 D + +TG+T VG++VM AAA+ +L PV+LELGGKSP + D DLD+ + + Y Sbjct: 252 MDVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFATY 311 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKE-TVKEFYGENIKESPDYERIINLRHFKRILS 293 N G+ C+A I + + ++ V K E K G+ S ++ ++++L Sbjct: 312 TNKGEICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKVLR 371 Query: 294 LL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDE 347 + EG + GG+ + YI PT+ TDV + Q+EIFGP++ ++ K V+E Sbjct: 372 YIDIGKREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTVEE 431 Query: 348 AINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGM 407 I N LA + + N + + +G + N PFGG SG Sbjct: 432 VIQKANNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWIN--CYFAFDPDAPFGGYKMSGF 489 Query: 408 GAYHGKHSFDTFSHQRPCL 426 G G + D + + + Sbjct: 490 GKDMGMDALDKYLQTKTVV 508 >4GO4-A nrPDB Length = 495 Score = 460 bits (1184), Expect = e-130, Method: Composition-based stats. Identities = 99/434 (22%), Positives = 192/434 (44%), Gaps = 21/434 (4%) Query: 9 RQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEI 68 ++AF + + R + L L ++E +++ + + + +V Sbjct: 50 KRAFPAWSALGAAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACF 109 Query: 69 DFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAA 128 + + + + + + + Y+Q +P+GVV I WN+P + T + A+AA Sbjct: 110 RYF-GGMADKIEGSVIPVDAGFLN---YVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAA 165 Query: 129 GNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELLKQRFD--HIFYTG 185 GN ++IKPSE++ + + +L+ + + + V+ G + L + D I +TG Sbjct: 166 GNTIVIKPSEITPLSTLRIVELMTEVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTG 225 Query: 186 NTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPD 245 +TA G+ ++EA+ +L + LELGGK + +D +++ W + N GQ CIA Sbjct: 226 STATGRRIVEASKSNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGS 285 Query: 246 YILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE-----GQK 299 ++ + +Q + + K G+ + + + + R+LS ++ G K Sbjct: 286 RLILHKDIADQFLERFIALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGK 345 Query: 300 IAFGGETDE-----ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINE 354 + GG+ + Y+ PTV+ + P+ +V QEE+FGP + +V + +EA+ N Sbjct: 346 VLAGGKAPDDKALANGFYVEPTVV-EAKPQDRVCQEEVFGPFVTVVRFSSDEEALAIANN 404 Query: 355 REKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKH 414 E L +++ N +M +G N PFGGVG SG G G Sbjct: 405 TEYGLGSGLWTQNLARAHKMAHAIHAGMCWIN--CYKRVSPGSPFGGVGQSGYGREMGFE 462 Query: 415 SFDTFSHQRPCLLK 428 + ++ R + Sbjct: 463 AIHDYTEARSVWVN 476 >3JZ4-A nrPDB Length = 481 Score = 459 bits (1182), Expect = e-129, Method: Composition-based stats. Identities = 96/431 (22%), Positives = 186/431 (43%), Gaps = 16/431 (3%) Query: 3 LEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVI 62 + +A + R+ + R L ++ E + D+ + + K E+ Sbjct: 51 AAIDAANRALPAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAE-AKGEIS 109 Query: 63 TVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPL 122 I++ E + QP+GV I WN+P + + Sbjct: 110 YAASFIEWFAEEGKRIYGDTIPGHQ---ADKRLIVIKQPIGVTAAITPWNFPAAMITRKA 166 Query: 123 IGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTELL--KQRFD 179 A+AAG +++KP+ + +A LA+L + + ++ V+ G L Sbjct: 167 GPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVR 226 Query: 180 HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQ 239 + +TG+T +G+ +ME AK + V+LELGG +P + D DLD K+ N GQ Sbjct: 227 KLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQ 286 Query: 240 TCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL--- 295 TC+ + + + + ++ K+++ + + G+ + +I+ + ++ + Sbjct: 287 TCVCANRLYVQDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADA 346 Query: 296 --EGQKIAFGGETDE-ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFI 352 +G ++ GG+ E + PT+L DV KV +EE FGP+ P+ K+ + I Sbjct: 347 LEKGARVVCGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQA 406 Query: 353 NEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 N+ E LA Y ++ + + R+ + G V N I+ + PFGG+ +SG+G Sbjct: 407 NDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGIISNEV--APFGGIKASGLGREGS 464 Query: 413 KHSFDTFSHQR 423 K+ + + + Sbjct: 465 KYGIEDYLEIK 475 >4O5H-A nrPDB Length = 511 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 95/427 (22%), Positives = 183/427 (42%), Gaps = 14/427 (3%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLEN 74 R+ R + + L +++ +++ + D K +V +M Sbjct: 86 WRTAKTTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGW 145 Query: 75 LPEWVTAKPVKKNVLTMLDE--AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAV 132 + + E AY + +P+GVV I WN+P ++ + A+A G V Sbjct: 146 ATKIEGSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTV 205 Query: 133 IIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTAV 189 ++KP+E + +A L +L+ + ++ G L R D I +TG+T Sbjct: 206 VLKPAEDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQT 265 Query: 190 GKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILC 249 GK + AA ++T ++LELGGKSP + D DLD + + + N GQ C A Sbjct: 266 GKTIGHAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYI 325 Query: 250 EASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGET-- 306 + + + ++ ++ + G + + +++ + +R+ ++ Sbjct: 326 HSKVFDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAG 385 Query: 307 ----DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALY 362 D ++ PTVL D +V++EEIFGP+L +P +VD A+ N+ L Sbjct: 386 GRAIDGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGAS 445 Query: 363 VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQ 422 ++S++ I +++ ++G V N N+ PFGG+ SG G G+ D ++ Sbjct: 446 IWSNDLSAIHKLVPRIAAGTVWVN--CHSLLDNALPFGGMKQSGFGRELGRAVIDQYTES 503 Query: 423 RPCLLKS 429 + ++ Sbjct: 504 KSVMMNY 510 >4I8Q-A nrPDB Length = 514 Score = 447 bits (1150), Expect = e-126, Method: Composition-based stats. Identities = 117/441 (26%), Positives = 206/441 (46%), Gaps = 18/441 (4%) Query: 1 MELEVRRVRQAFLS--GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 +++ V R+A S R + L A+ V E++ + T + D K+ + Sbjct: 63 VDIAVEAARKAIARDDWGSTTGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESA- 121 Query: 59 QEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 ++ V G ++ + + N+ + ++Y+ +PLGVV +I WNYP ++ Sbjct: 122 ADMDDVAGCFEYYAGLAEALDSRRMTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMA 181 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVING-GVEETTELL-K 175 I + A+AAG A I+KPSEL+ T L ++ + L ++ G G E L Sbjct: 182 IWKVAPALAAGCAAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGPLASH 241 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCD-LDIVCRRITWGKY 234 D I +TG+ G +M AAA+ + PV+L LGGKSP + D D LDI +G + Sbjct: 242 PHVDKISFTGSGPTGSKIMTAAAQLVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIF 301 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILS 293 N GQ C A ++ + ++ + + ++ + K + ++E +++ ++++L Sbjct: 302 ANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLK 361 Query: 294 LL-----EGQKIAFGGETDE---ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 + EG I GGE + Y+ PT++TDV+ ++ +EE+FGP+L + K Sbjct: 362 FISNAKSEGATILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTE 421 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 ++AI N+ + L V S + K +R +G + N F N P+GG S Sbjct: 422 EQAIELANDTKYGLGAAVMSKDVKRCERFTKAFQTGIIWINCSQPTF--NELPWGGKKRS 479 Query: 406 GMGAYHGKHSFDTFSHQRPCL 426 G G GK + F + + Sbjct: 480 GFGRDLGKWGLENFLNIKQVT 500 >6C43-A nrPDB Length = 477 Score = 447 bits (1149), Expect = e-126, Method: Composition-based stats. Identities = 106/429 (24%), Positives = 184/429 (42%), Gaps = 17/429 (3%) Query: 11 AFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDF 70 AF + R + L L +++ + + + K V + E+ ++ F Sbjct: 54 AFAEWGQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRF 113 Query: 71 MLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGN 130 + + I+ P+GVV I WNYP ++ L A+AAGN Sbjct: 114 FAGAARCLSG---LAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGN 170 Query: 131 AVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTA 188 V+IKPSE++ TA LA L + V+ G + ++L ++ + TG+ A Sbjct: 171 CVVIKPSEITPLTALKLAVLAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIA 230 Query: 189 VGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYIL 248 G+ ++ A + +ELGGK+P + D DLD V + + + N GQ C A I Sbjct: 231 TGEHILRHTAPAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIY 290 Query: 249 CEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLEGQK-------I 300 + + + +V K+ V G ES + + +L H KR+ + +E K I Sbjct: 291 AQRGIYDALVEKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVI 350 Query: 301 AFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360 G +T+ Y APT+L D + ++Q E+FGP++ I + D+ + + N+ LA Sbjct: 351 TGGSQTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLA 410 Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFT-LNSFPFGGVGSSGMGAYHGKHSFDTF 419 V++ + R+ G N HF ++ P GG SG G + + + Sbjct: 411 SSVWTQDVGRAHRLSARLQYGCTWIN---THFMLVSEMPHGGQKQSGYGKDMSLYGLEDY 467 Query: 420 SHQRPCLLK 428 + R ++K Sbjct: 468 TLVRHIMVK 476 >6B4R-B nrPDB Length = 497 Score = 446 bits (1148), Expect = e-126, Method: Composition-based stats. Identities = 107/443 (24%), Positives = 194/443 (43%), Gaps = 22/443 (4%) Query: 2 ELEVRRVRQAFL--SGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQ 59 E V+ R AF + R Q + ++ E +++ D+ K + Sbjct: 60 EQAVKVARNAFDSGAWSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISDSLHI 119 Query: 60 EVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI 119 +V + + + E + + + + + +P+GVV I WN+P +++ Sbjct: 120 DVASAANSLRWSAEAIDKIYD----EVAATPHAELGLVTREPVGVVAAIVPWNFPLLMSC 175 Query: 120 QPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTELL--KQ 176 L A+A GN+VI+KPSE S TA +A+L + + + ++ V+ G + L Sbjct: 176 WKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKALALHM 235 Query: 177 RFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDC-DLDIVCRRITWGKY 234 D + +TG+T + K +M A + ++ V LE GGKSP + D DL Sbjct: 236 DVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIA 295 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRILS 293 N G+ C A +L E S++++ + + E +K + G + + +++ + +LS Sbjct: 296 FNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQMNTVLS 355 Query: 294 LLE-----GQKIAFGGET---DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 +E G K+ GG+ + Y+ PT+ V K+ +EEIFGP+L ++ ++ Sbjct: 356 YIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDA 415 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 +EA+ N+ LA V++ N +G V N PFGG S Sbjct: 416 EEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQYDGGDMT--APFGGFKQS 473 Query: 406 GMGAYHGKHSFDTFSHQRPCLLK 428 G G H+FD ++ + +K Sbjct: 474 GNGRDKSLHAFDKYTELKATWIK 496 >3I44-A nrPDB Length = 497 Score = 446 bits (1147), Expect = e-125, Method: Composition-based stats. Identities = 111/437 (25%), Positives = 196/437 (44%), Gaps = 21/437 (4%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 + + ++AF + ++ RL +E + + ++R D+ I+ ++ + + Sbjct: 66 DKAINAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQT 125 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 121 T I ++ E+ ++ ++ ++A + +GVV +I WN+P Sbjct: 126 ATGSSHIRNFIKAYKEF----SFQEALIEGNEQAILHYDAIGVVGLITPWNWPMNQVTLK 181 Query: 122 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFD- 179 +I A+ AG +++KPSE++ +A + A++L + L ++ +ING L D Sbjct: 182 VIPALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHPDL 241 Query: 180 -HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 I +TG+T GK + + A+ L V LELGGK I D D+D +R + N G Sbjct: 242 EMISFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYNSG 300 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETV-KEFYGENIKESPDYERIINLRHFKRILSLL-- 295 Q+C AP +L E ++ ++ + K+ K G + +++ + +I L+ Sbjct: 301 QSCNAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQS 360 Query: 296 ---EGQKIAFGGET----DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 EG + GG E Y+ PTV DV P ++ +EEIFGP+L ++P DEA Sbjct: 361 GIDEGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEA 420 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 + N+ E L Y+ S + +R+ + SG V N H FGGV SG Sbjct: 421 VTLANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVEVNG---HELPGGSYFGGVKFSGRA 477 Query: 409 AYHGKHSFDTFSHQRPC 425 G F + Sbjct: 478 REGGLWGIKEFLDTKAI 494 >2D4E-A nrPDB Length = 515 Score = 445 bits (1145), Expect = e-125, Method: Composition-based stats. Identities = 116/445 (26%), Positives = 192/445 (43%), Gaps = 25/445 (5%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ + +AF + R + L + ++++ ++ D + V + Sbjct: 66 VDRAAKAAHEAFQRWSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVR-AQ 124 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V F E + + + Y P G V II WN P +L+ Sbjct: 125 VARAAENFAFYAEYAEHAMEDRTF---PVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTW 181 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR-- 177 + A+A GN V++KP+E S TA LA++L + L ++ ++ G EE L Sbjct: 182 RIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPL 241 Query: 178 FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 + TG T GKIVM AA HL ++ ELGGKSP + D DL+ + + + Sbjct: 242 VPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFN 301 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL- 295 G+ C A +L E + V K+ E + G + + +I+ H +R+L + Sbjct: 302 GERCTASSRLLVEEKIFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVE 361 Query: 296 ----EGQKIAFGGETDE---------ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV 342 EG ++ GGE + Y+ PTV + K+ QEEIFGP+L +P Sbjct: 362 AGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIPF 420 Query: 343 KNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGV 402 K+ +EA+ N+ + LA YVF+ + + R+ E +G V N + PFGGV Sbjct: 421 KDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPT--PFGGV 478 Query: 403 GSSGMGAYHGKHSFDTFSHQRPCLL 427 SG G ++ D ++ + L Sbjct: 479 KGSGDRREGGTYALDFYTDLKTIAL 503 >3RHO-A nrPDB Length = 517 Score = 445 bits (1144), Expect = e-125, Method: Composition-based stats. Identities = 110/444 (24%), Positives = 197/444 (44%), Gaps = 17/444 (3%) Query: 1 MELEVRRVRQAFLS--GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 ++ V ++AF + R R + L L ++++ ++++ T A D Sbjct: 76 VDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALK 135 Query: 59 QEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 V + + + A + + +P+GV I+ WNYP ++ Sbjct: 136 THVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMML 195 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTELL--K 175 +AAGN V+IKP++++ TA A+L L + + + ++ G + L Sbjct: 196 SWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDH 255 Query: 176 QRFDHIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 I +TG+T VGK +M++ A ++ V+L+LGGKSP I DCDL+ + + Sbjct: 256 PDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVF 315 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILS 293 N G+ CIA + E S+ NQ V K+ E V++ G ++ ++ + H ++++ Sbjct: 316 FNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVE 375 Query: 294 L-----LEGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVK--NV 345 EG + GG + + PTV TDV+ + +EE FGPI+ I +V Sbjct: 376 YCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDV 435 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 D ++ N E LA VF+ + + D+ +G V N + T + PFGG S Sbjct: 436 DAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFIN--TYNKTDVAAPFGGFKQS 493 Query: 406 GMGAYHGKHSFDTFSHQRPCLLKS 429 G G G+ + + + + + Sbjct: 494 GFGKDLGEAALNEYLRIKTVTFEY 517 >3TY7-A nrPDB Length = 478 Score = 439 bits (1129), Expect = e-123, Method: Composition-based stats. Identities = 111/440 (25%), Positives = 196/440 (44%), Gaps = 28/440 (6%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ V +L R ++ R L+ + + + R+ DI+ AI +L Sbjct: 47 VDKAVEAADDVYLEFRHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAPL------- 99 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKN--VLTMLDEAYIQPQPLGVVLIIGAWNYPFVLT 118 L E L +V A+ N + + + +GV +I WN+P T Sbjct: 100 ---SLSERVHYQMGLNHFVAARDALDNYEFEERRGDDLVVKEAIGVSGLITPWNFPTNQT 156 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELLKQR 177 L A AAG+ V++KPSE + A ILA++ + + + ++ ++NG L + Sbjct: 157 SLKLAAAFAAGSPVVLKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEH 216 Query: 178 --FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 + +TG+ G +ME AAK V+LELGGKSP + D D+ + T Sbjct: 217 PKVRMMSFTGSGPTGSKIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVN 276 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSL 294 N GQ C A +L +++ + ++KE + G ++ II+ + F ++ + Sbjct: 277 NTGQVCTAGTRVLVPNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNY 336 Query: 295 L-----EGQKIAFGG----ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 + EG ++ +GG E E + PT+ +VD + + QEEIFGP++ ++ ++ Sbjct: 337 INKGIEEGAELFYGGPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDL 396 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 DEAI N+ + LA YV + + + ++ +G V N+ PFGG S Sbjct: 397 DEAIQIANDTKYGLAGYVIGKDKETLHKVARSIEAGTVEINEA---GRKPDLPFGGYKQS 453 Query: 406 GMGAYHGKHSFDTFSHQRPC 425 G+G G + + F + Sbjct: 454 GLGREWGDYGIEEFLEVKSI 473 >5IUV-A nrPDB Length = 497 Score = 437 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 100/443 (22%), Positives = 188/443 (42%), Gaps = 22/443 (4%) Query: 2 ELEVRRVRQAFL--SGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQ 59 + V R AF + R + ++++ +++ D+ K + Sbjct: 60 QRAVESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGV 119 Query: 60 EVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI 119 ++ + + E + + + L + +P+GVV I WN+P ++ Sbjct: 120 DIPGGARALSWSGEAIDKLYDEVAATPHDQLGL----VTREPVGVVAAIVPWNFPLMMAC 175 Query: 120 QPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTELL--KQ 176 L A++ GN+V++KPSE S TA +A+L + + + V+ G + L Sbjct: 176 WKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHM 235 Query: 177 RFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDC-DLDIVCRRITWGKY 234 D + +TG+T + K +M A + ++ V LE GGKSP + D DL Sbjct: 236 DVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIA 295 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRILS 293 N G+ C A +L E S++++ + + E + + G + + + +++ + +LS Sbjct: 296 FNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLS 355 Query: 294 LL-----EGQKIAFGGET---DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 + +G ++ GG+ + Y+ PT+ V+ ++ QEEIFGP+L ++ Sbjct: 356 YIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTA 415 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 +EAI N+ LA V++ N +G V N PFGG S Sbjct: 416 EEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMT--APFGGFKQS 473 Query: 406 GMGAYHGKHSFDTFSHQRPCLLK 428 G G H+FD ++ + +K Sbjct: 474 GNGRDKSLHAFDKYTELKSTWIK 496 >4F3X-A nrPDB Length = 498 Score = 437 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 111/441 (25%), Positives = 185/441 (41%), Gaps = 17/441 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ V +AF+ R L + +++ + A + K V + E Sbjct: 64 IDAAVDAAERAFVGWSQTTPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKNDE 123 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + ++ F + P L + I+ P+G+V I WNYP ++ Sbjct: 124 LPAIIDCWRFFAGAVRNL--HAPAAGEYLPGHT-SMIRRDPIGIVGSIAPWNYPLMMMAW 180 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL--KQRF 178 L AI GN V+ KPSE + TA LA+L+ L + + VI G E L + Sbjct: 181 KLAPAIGGGNTVVFKPSEQTPLTALKLARLIADILPEGVVNVITGRGETVGNALINHPKV 240 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 + TG+ A GK V+ AAAK + LELGGK+P + D DL+ V I Y N G Sbjct: 241 GMVSITGDIATGKKVLAAAAKTVKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAG 300 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEFYGE-NIKESPDYERIINLRHFKRILSLLEG 297 Q C A I EA + ++V + V + + +I+ R R+ S +E Sbjct: 301 QDCTAACRIYAEAGIYEKLVADLTSAVSTIRYNLDDDTENEIGPLISRRQRDRVASFVER 360 Query: 298 Q------KIAFGGETD-EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 +I GG T + + PTV+ + ++++ E+FGP++ + D+A+ Sbjct: 361 AADQKHIEITTGGRTGSDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVA 420 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTL-NSFPFGGVGSSGMGA 409 + N+ + LA V++ + R G N HF L N P GG+ SG G Sbjct: 421 WANDSDYGLASSVWTKDISKAMRAASRLQYGCTWIN---THFMLTNEMPHGGIKQSGYGK 477 Query: 410 YHGKHSFDTFSHQRPCLLKSL 430 ++ + ++ R ++ Sbjct: 478 DMSVYALEDYTAVRHIMINHG 498 >1WNB-A nrPDB Length = 495 Score = 434 bits (1117), Expect = e-122, Method: Composition-based stats. Identities = 101/429 (23%), Positives = 186/429 (43%), Gaps = 23/429 (5%) Query: 14 SGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFML- 72 + R + L L +++E + + + K + ++ E+ ++ F Sbjct: 75 EWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAG 134 Query: 73 --ENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGN 130 L + ++ + + I+ PLGVV I WNYP ++ L A+AAGN Sbjct: 135 AARCLNGLAAGEYLEGHT------SMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGN 188 Query: 131 AVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTA 188 V++KPSE++ TA LA+L + ++ G + + L + + TG+ A Sbjct: 189 CVVLKPSEITPLTALKLAELAKDIFPAGVVNILFGRGKTVGDPLTGHPKVRMVSLTGSIA 248 Query: 189 VGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYIL 248 G+ ++ A + +ELGGK+P + D D++ V + Y N GQ C A I Sbjct: 249 TGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIY 308 Query: 249 CEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRILSLLEGQ------KIA 301 + + + +V K+ V G ES + + +L H +R+ +E K+ Sbjct: 309 AQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVI 368 Query: 302 FGG-ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLA 360 GG + Y APT+L ++Q+E+FGP++ + P N ++ +N+ N+ + LA Sbjct: 369 TGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLA 428 Query: 361 LYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFT-LNSFPFGGVGSSGMGAYHGKHSFDTF 419 V++ + R+ G N HF ++ P GG SG G + + + Sbjct: 429 SSVWTKDVGRAHRVSARLQYGCTWVN---THFMLVSEMPHGGQKLSGYGKDMSLYGLEDY 485 Query: 420 SHQRPCLLK 428 + R ++K Sbjct: 486 TVVRHVMVK 494 >5KLK-A nrPDB Length = 520 Score = 432 bits (1111), Expect = e-121, Method: Composition-based stats. Identities = 107/445 (24%), Positives = 190/445 (42%), Gaps = 19/445 (4%) Query: 1 MELEVRRVRQAFLS-GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQ 59 + V + A ++ R + + +Q R ++ + A AD + + Sbjct: 77 VNEAVVAAQNALKGPWGKLSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQARTL 136 Query: 60 EVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI 119 ++ + + T Y +PLGV+ +I W+ P +L Sbjct: 137 DIPRAIANFRTFADLAKTSHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLFT 196 Query: 120 QPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVING-GVEETTELLKQR 177 + A+A GN V+ KPSE S ++A +LA+++ + ++ +I+G G + E L Q Sbjct: 197 WKVAPALACGNTVVAKPSEESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLTQH 256 Query: 178 --FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 + +TG + G +M+A A + V+ ELGGK+ + D DLD + + Sbjct: 257 PGISALTFTGESKTGSTIMKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSFT 316 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKI-KETVKEFYGENIKESPDYERIINLRHFKRILSL 294 N GQ C+ + + S+ ++ V + E + G ++ + +I+ H ++LS Sbjct: 317 NSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVLSY 376 Query: 295 -----LEGQKIAFGGETD------EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVK 343 EG + GG + Y+ PT+ T + K + + EEIFGP+ I P Sbjct: 377 YRLAVDEGATVVTGGGVPKFNDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPFD 436 Query: 344 NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVG 403 + DE IN +N+ LA +++ N R+ + G V N + PFGGV Sbjct: 437 DEDEVINRVNDSNYGLACAIWTTNLSRAHRVSRQIHVGLVWVNTWYLRDL--RTPFGGVK 494 Query: 404 SSGMGAYHGKHSFDTFSHQRPCLLK 428 SG+G G+ S D +S +K Sbjct: 495 LSGLGREGGRFSMDFYSDIANICIK 519 >3B4W-A nrPDB Length = 495 Score = 430 bits (1105), Expect = e-121, Method: Composition-based stats. Identities = 115/424 (27%), Positives = 193/424 (45%), Gaps = 18/424 (4%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLEN 74 S P R + A +M+ ER+ +AA+ + + + + +G +++ Sbjct: 64 WPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNYFAGA 123 Query: 75 LPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 + + + ++ + +P+GVV I AWN P L + + A+ AG +++ Sbjct: 124 ADKVTWTETRTGSY----GQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVL 179 Query: 135 KPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTEL-LKQRFDHIFYTGNTAVGKI 192 KP+ + TA LA++ + L + + V+ GG+E L D +TG++AVG+ Sbjct: 180 KPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGRE 239 Query: 193 VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEAS 252 V AA+ L P TLELGGKS I +D DL + + MN GQ C+ IL S Sbjct: 240 VGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRS 299 Query: 253 LQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGET 306 ++IV + V G + +I+ + R+ + EG ++ GG Sbjct: 300 RYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR 359 Query: 307 DEA---TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYV 363 E +I PTV DVD K + QEEIFGP+L I+P ++AI N+ LA V Sbjct: 360 PEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSV 419 Query: 364 FSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 ++ + ++ + +G N + PFGG +SG+G +G + F+ Q+ Sbjct: 420 WTTDVPKGIKISQQIRTGTYGIN---WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQK 476 Query: 424 PCLL 427 LL Sbjct: 477 SVLL 480 >4QYJ-A nrPDB Length = 516 Score = 429 bits (1104), Expect = e-120, Method: Composition-based stats. Identities = 99/445 (22%), Positives = 185/445 (41%), Gaps = 18/445 (4%) Query: 1 MELEVRRVRQA--FLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYS 58 + V + R P R + L L +++ ++ + K Sbjct: 74 VNAAVESAAATLRSDTWRRMPPSARERILLRLADLLEVHGDELARLETLNNGKLLIYSKL 133 Query: 59 QEVITVLGEIDFMLENLPEWVTAKP--VKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 116 EV + +M + + + A Q P+GVV I WN+P + Sbjct: 134 MEVGASAQWLRYMAGWATKLTGSTLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNFPLL 193 Query: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTELL- 174 + + + A+A GN V++KP+E + TA LA+L + L V+ G E + L Sbjct: 194 MAVWKIAPALACGNTVVLKPAEETPLTALRLAELAMEAGLPAGALNVVTGRGETAGDALV 253 Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 + + +TG+T VG+I+ A + L V+LELGGKSP + DCD Sbjct: 254 RHPKVAKVAFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVLADCDPQEAAEGAAAAI 313 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL 292 + N GQ C A + S+ ++ ++ + G +++ +++ +H + +L Sbjct: 314 FFNHGQVCTAGSRLYVHESIYEDVIQRLAVIGESIVVGSGLEQGVHMGPMVSKKHHENVL 373 Query: 293 -----SLLEGQKIAFGGETDE--ATRYIAPTVLTDV-DPKTKVMQEEIFGPILPIVPVKN 344 + +G + GG ++ PT+ + +++ +E+FGP+L P + Sbjct: 374 RHIRNGIEDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLLSQEVFGPVLVATPFSD 433 Query: 345 VDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGS 404 + E +N N L +++++ R+ DE +G V N M + PFGG Sbjct: 434 IAEVVNEANRSVYGLGASIWTNDLSAALRINDELEAGTVWVNTHNM--VDPNLPFGGFKD 491 Query: 405 SGMGAYHGKHSFDTFSHQRPCLLKS 429 SG+G HG + + ++ R ++ Sbjct: 492 SGVGREHGAAAIEHYTTTRSLVIAY 516 >4V6H-A nrPDB Length = 484 Score = 429 bits (1103), Expect = e-120, Method: Composition-based stats. Identities = 98/419 (23%), Positives = 175/419 (41%), Gaps = 16/419 (3%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLEN 74 R + + R L +V D+ + + K E+ I++ E Sbjct: 66 WRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAE-AKGEIAYAASFIEWFAEE 124 Query: 75 LPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 + +P+GV I WN+P + + + A+AAG +++ Sbjct: 125 GKRVAGDT---LPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVV 181 Query: 135 KPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGK 191 KP+E + +A +A L + + + + V+ G + + + +TG+TAVG+ Sbjct: 182 KPAESTPFSALAMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGR 241 Query: 192 IVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEA 251 ++M +A + +TLELGG +P + D DLD KY N GQTC+ + Sbjct: 242 LLMAQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHE 301 Query: 252 SLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE 305 + + K+ V + G + +IN K++ S + +G + GG+ Sbjct: 302 RVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGK 361 Query: 306 TDEATR-YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364 + PTVLT V P V +EE FGP+ P+ + +E + N+ E LA Y++ Sbjct: 362 RHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLY 421 Query: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 S + + R+ + G V N ++ + PFGGV SG+G + D + + Sbjct: 422 SRDIGRVWRVAEALEYGMVGINTGLISNEV--APFGGVKQSGLGREGSHYGIDDYVVIK 478 >3K2W-A nrPDB Length = 497 Score = 423 bits (1087), Expect = e-118, Method: Composition-based stats. Identities = 117/426 (27%), Positives = 192/426 (45%), Gaps = 26/426 (6%) Query: 20 LRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWV 79 R R L ++E + + + A+ K +V EV ID+ +N Sbjct: 71 ARTRQNMLRTFANKIRENKHILAPMLVAEQGKLL-SVAEMEVDVTATFIDYGCDN----- 124 Query: 80 TAKPVKKNVLT---MLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKP 136 A ++ ++L ++ YI P GVV+ I AWN+P L + + A+ GN +++KP Sbjct: 125 -ALTIEGDILPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKP 183 Query: 137 SELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRF--DHIFYTGNTAVGKIV 193 ++ + L ++ + L + VING + L + I TG+T GK + Sbjct: 184 TQETPLATTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQI 243 Query: 194 MEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASL 253 + +A+++TPV LELGGK+P + D DLD WG++ NCGQ C + + AS+ Sbjct: 244 YKTSAEYMTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASV 303 Query: 254 QNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI-----LSLLEGQKIAFGGETD 307 ++ + K VK G+ + N R I ++ +G +A GG+T Sbjct: 304 YDEFMAKFLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTA 363 Query: 308 -----EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALY 362 E + PTVL DV V+ EE FGPILPIV V ++++AI F N+ L+ Y Sbjct: 364 TVEGFEGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAY 423 Query: 363 VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQ 422 V + + I + I + G V N + + G SG G GK + + + Sbjct: 424 VHTQSFANINQAISDLEVGEVYINRGM--GEQHQGFHNGWKQSGFGGEDGKFGLEQYLEK 481 Query: 423 RPCLLK 428 + + Sbjct: 482 KTVYIN 487 >4LIH-A nrPDB Length = 504 Score = 421 bits (1082), Expect = e-118, Method: Composition-based stats. Identities = 115/426 (26%), Positives = 197/426 (46%), Gaps = 18/426 (4%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLEN 74 R R L +++E ++ D K + + +V +++ E Sbjct: 83 WAGLNPRARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAEA 142 Query: 75 LPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 + + + L L + +P+GVV + WN+P ++ A+AAGN+V++ Sbjct: 143 IDKVGGEVAPADHHLVGL----VTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVVL 198 Query: 135 KPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTEL-LKQRFDHIFYTGNTAVGKI 192 KPSE S TA +A+L + ++ V+ G E L L + D I +TG+TAVGK+ Sbjct: 199 KPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAGEPGKLLALHRDVDCIAFTGSTAVGKL 258 Query: 193 VMEAAAK-HLTPVTLELGGKSPCYIDKDC-DLDIVCRRITWGKYMNCGQTCIAPDYILCE 250 +M+ AA+ +L LELGGKSP + DC DLD + + N G+ C A +L Sbjct: 259 IMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLVH 318 Query: 251 ASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRILSLLEGQK----IAFGGE 305 +++ + K+ + + G + S I++ +R+L +E + + GG Sbjct: 319 RDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEGRLVTGGA 378 Query: 306 T---DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALY 362 + Y+ PTV +V P K+ +EEIFGP+L ++ +VDEA+ N+ E LA Sbjct: 379 RVNAETGGFYVEPTVF-EVKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAAA 437 Query: 363 VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQ 422 V++ N + +G V N +N FPFGG SG G H+ + ++ Sbjct: 438 VWTSNLTTAHDVSRRLRAGTVWVNCYDEGGDMN-FPFGGYKQSGNGRDKSLHALEKYTEL 496 Query: 423 RPCLLK 428 + L++ Sbjct: 497 KSTLIR 502 >5TJR-A nrPDB Length = 531 Score = 417 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 108/468 (23%), Positives = 203/468 (43%), Gaps = 35/468 (7%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 M+ + + AF + R+ P R Q L +++++ E+ I+ I+ + K+ Sbjct: 75 MQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEANEERIVKLISEEHGKT-------- 126 Query: 61 VITVLGEIDFMLENLPEWVTAKP------VKKNVLTMLDEAYIQPQPLGVVLIIGAWNYP 114 + GE+ +EN+ E+ TA P +NV +D A+ QP+GVV I +N+P Sbjct: 127 IEDAAGELKRGIENV-EYATAAPEILKGEYSRNVGPNID-AWSDFQPIGVVAGITPFNFP 184 Query: 115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTEL 173 ++ + AIA GN I+KPSE ++ ++A+L + L + + V++G L Sbjct: 185 AMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKGAVDAL 244 Query: 174 L-KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 + + + G+T + + + K V G K+ + D DLD + Sbjct: 245 IEAPEVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGA 304 Query: 233 KYMNCGQTCIAPDYIL-CEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKR 290 Y +CG+ C+A + + + +V K+ +K G D ++ + Sbjct: 305 AYGSCGERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDK 364 Query: 291 ILSLLE-----GQKIAFGGET-----DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 + ++ G ++ G E ++ T+ V P+ + +EEIFGP+L IV Sbjct: 365 VTGYIDTGVAQGAELVVDGRGYKVAGHENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCIV 424 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFG 400 V +++EA+ IN+ E +F+ + + + DE G V N V + + FG Sbjct: 425 RVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVN-VPLPVPVAYHSFG 483 Query: 401 GVGSSGMGAYH--GKHSFDTFSHQRPCLLKSLKREG--ANKLRYPPNS 444 G S G H G ++ ++ + +R+ A + +P NS Sbjct: 484 GWKRSLFGDLHAYGPDGVRFYTKRKAITQRWPQRKSHEAAQFAFPSNS 531 >2HG2-A nrPDB Length = 479 Score = 417 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 112/437 (25%), Positives = 197/437 (45%), Gaps = 17/437 (3%) Query: 4 EVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 + +A + P R L + ++ER +I I + K + + EV Sbjct: 49 AIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQ-QLAEVEVAF 107 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLI 123 ID+M E + + + + LGV I WN+PF L + + Sbjct: 108 TADYIDYMAEWARRYEGEIIQSDRPGENI---LLFKRALGVTTGILPWNFPFFLIARKMA 164 Query: 124 GAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL--KQRFDH 180 A+ GN ++IKPSE + N A AK++ + L + ++ ++ G E + L + Sbjct: 165 PALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAM 224 Query: 181 IFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQT 240 + TG+ + G+ +M AAK++T V LELGGK+P + D DL++ + I + +N GQ Sbjct: 225 VSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQV 284 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPD--YERIINLRHFKRIL-----S 293 C + + + + +Q V ++ E ++ N E D +IN +R+ + Sbjct: 285 CNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARA 344 Query: 294 LLEGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFI 352 + EG ++AFGG+ + Y PT+L DV + +M EE FGP+LP+V +++AI+ Sbjct: 345 VEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMA 404 Query: 353 NEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 N+ + L +++ N + + I G N +F G SG+G G Sbjct: 405 NDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRE--NFEAMQGFHAGWRKSGIGGADG 462 Query: 413 KHSFDTFSHQRPCLLKS 429 KH + + L+S Sbjct: 463 KHGLHEYLQTQVVYLQS 479 >3RHD-A nrPDB Length = 486 Score = 416 bits (1070), Expect = e-117, Method: Composition-based stats. Identities = 103/442 (23%), Positives = 204/442 (46%), Gaps = 26/442 (5%) Query: 4 EVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 + + ++ P+ R L + + ++E+++++ +A D K EV Sbjct: 39 AIDTAEKYKEVMKNLPITKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQAR-VEVER 97 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLI 123 +G + E + + + + + +P+G+V I +N+P L+ + Sbjct: 98 SIGTFKLAAFYVKE-----HRDEVIPSDDRLIFTRREPVGIVGAITPFNFPLNLSAHKIA 152 Query: 124 GAIAAGNAVIIKPSELSENTAKILAKLLPQYL-----DQDLYIVINGGVEETTE--LLKQ 176 AIA GN ++ PS + LAK++ L +Y ++ G E + ++ + Sbjct: 153 PAIATGNVIVHHPSSKAPLVCIELAKIIENALKKYNVPLGVYNLLTGAGEVVGDEIVVNE 212 Query: 177 RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 236 + + I +TG++ VG+++ + A + LELGG +P + KD DL+ + G ++ Sbjct: 213 KVNMISFTGSSKVGELITKKAG--FKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIY 270 Query: 237 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL 295 GQ CI+ IL + S+ ++ + K G + E D +I++ H + + ++ Sbjct: 271 AGQVCISVGMILVDESIADKFIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEWVEKVV 330 Query: 296 -----EGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 EG K+ GG+ D+A Y PT+L +VD + + E F P++PI+ N +E I+ Sbjct: 331 EKAIDEGGKLLLGGKRDKALFY--PTIL-EVDRDNILCKTETFAPVIPIIR-TNEEEMID 386 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 N E L +F+++ + + GGV ND + F ++ PFGGV SG+G Sbjct: 387 IANSTEYGLHSAIFTNDINKSLKFAENLEFGGVVINDSSL-FRQDNMPFGGVKKSGLGRE 445 Query: 411 HGKHSFDTFSHQRPCLLKSLKR 432 K++ + S+ + ++ + Sbjct: 446 GVKYAMEEMSNIKTIIISKAEN 467 >5NNO-A nrPDB Length = 546 Score = 415 bits (1068), Expect = e-116, Method: Composition-based stats. Identities = 212/461 (45%), Positives = 297/461 (64%), Gaps = 18/461 (3%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 V + R+AF +R L+ R Q L +L +V+E + AI D + E++ + Sbjct: 21 VSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETVVMEILPL 80 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 E+ ++E++ E+V LD+ +Q +PLGVVL+IG WNYP +L +QPL+G Sbjct: 81 RNEVWHLIEHMDEYVKPVKPTMEGAAALDDCELQYEPLGVVLVIGTWNYPLLLILQPLLG 140 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184 A+AAGN +IKPSEL+ TA++L KLLP+Y+ D+ ++NGGV ETT +LK+RFDHI YT Sbjct: 141 ALAAGNTAVIKPSELAPATAELLTKLLPKYVSSDVVGIVNGGVSETTAVLKERFDHILYT 200 Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC--DLDIVCRRITWGKYMNCGQTCI 242 G+ V +IVM AAAKHLTPVTLELGGKSP +D C ++ +V RI WGK +N GQT I Sbjct: 201 GSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGKIINAGQTSI 260 Query: 243 APDYILCEASLQNQIVWKIKETVKEFYGE----------------NIKESPDYERIINLR 286 APDY++ E S+++ +V + E K G+ E DY RI+N Sbjct: 261 APDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQKQQFLEESDYPRIVNAS 320 Query: 287 HFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 HF+R++ ++G K+A GGE DEAT IAPT+LT++DP VMQEEIFGPILP++ +N Sbjct: 321 HFQRLMEFMKGGKVAVGGEADEATLTIAPTILTNIDPTHPVMQEEIFGPILPVLTYENEK 380 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 + + IN REKPLALYVFS+N + I+ + TSSG V NDV++H + PFGGVG SG Sbjct: 381 DILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVVHAGADGLPFGGVGRSG 440 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSK 447 MGAYHG++SF+TFSH+RP + + + +R+PP + +K Sbjct: 441 MGAYHGRYSFETFSHRRPVMRRGFLFSSIDTVRFPPYTTAK 481 >3RJL-A nrPDB Length = 538 Score = 415 bits (1066), Expect = e-116, Method: Composition-based stats. Identities = 105/440 (23%), Positives = 182/440 (41%), Gaps = 20/440 (4%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 E ++ +AF + R R L V+ ++ + + + K +N + Sbjct: 77 EKAIQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEAGKP-WNEADADT 135 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 121 + +++ + E KPV Y P GV ++I WN+ F + Sbjct: 136 AEAIDFMEYYARQMIELAKGKPVNSREGERNQYVYT---PTGVTVVIPPWNFLFAIMAGT 192 Query: 122 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELLKQRFDH 180 + I GN V++KP+ + A ++L + L + + + G E + L Sbjct: 193 TVAPIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKT 252 Query: 181 --IFYTGNTAVGKIVMEAAAK------HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 I +TG+ VG + E AAK HL V E+GGK +D+DCD+++ + I Sbjct: 253 SIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTS 312 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKE-TVKEFYGENIKESPDYERIINLRHFKRI 291 + GQ C A + + ++++ ++ E T + GE +I+ F +I Sbjct: 313 AFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKI 372 Query: 292 LSLLE----GQKIAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 + +E ++ GG+ D++ +I PT+ D+DPK ++MQEEIFGP++ V + D Sbjct: 373 MDYIEIGKEEGRLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFD 432 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 EA+ N E L V + N I R E G + N + PFGG SG Sbjct: 433 EALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 407 MGAY-HGKHSFDTFSHQRPC 425 + G + Sbjct: 493 TDSKAGGPDYLALHMQAKTI 512 >5UR2-A nrPDB Length = 984 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 106/439 (24%), Positives = 189/439 (43%), Gaps = 20/439 (4%) Query: 11 AFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDF 70 A+ + ++ P R ++ L ++ ++ ++ K + ++ + + Sbjct: 545 AYKTWKNVPCEQRAALVDKLADIMTRDRFKLIATQVLEVGKP-WAEADGDIGEAIDFCRY 603 Query: 71 MLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGN 130 ++ E KP++ L YI + GV +I WN+P + + A AGN Sbjct: 604 YARHMREL--QKPLRVGGLPGELSHYI-YKSRGVTAVIAPWNFPLAILAGMVTAAAVAGN 660 Query: 131 AVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR--FDHIFYTGNT 187 V++KP+E S A L K++ + Q + + G EE E + I +TG+ Sbjct: 661 TVVMKPAEQSTVVAWGLMKMIQEAGFPQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSK 720 Query: 188 AVGKIVMEAAA------KHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTC 241 AVG +M AA +H+ +E+GGK+ ID D DLD + + + GQ C Sbjct: 721 AVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKC 780 Query: 242 IAPDYILCEASLQNQIVWKIKETVKEFYGENIK-ESPDYERIINLRHFKRILSLLEGQ-- 298 A ++ + ++ V ++ ET K + +++ + RIL + Sbjct: 781 SAASRVIVLDEVYDRFVDRLVETAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEAEK 840 Query: 299 --KIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINERE 356 K+ F G + PT+ DV K+ Q EIFGP++ ++ KN+D+A++ N E Sbjct: 841 NHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTE 900 Query: 357 KPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY-HGKHS 415 L VFS + I R+ +E G + N I ++ PFGG SG+G+ G Sbjct: 901 YALTGGVFSRSPANINRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDY 960 Query: 416 FDTFSHQRPCLLKSLKREG 434 + C+ ++ R G Sbjct: 961 LKQYME-PACVTENTLRRG 978 >5UCD-A nrPDB Length = 457 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 166/425 (39%), Positives = 252/425 (59%), Gaps = 8/425 (1%) Query: 7 RVRQAFLSGRSR-PLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVL 65 ++A+ + R+ + FR Q LE L+ V ++ + +A+A DL K + V E+ VL Sbjct: 35 SAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEIGAVL 94 Query: 66 GEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGA 125 EIDF L +L EWV V + E Y+ +P GV IIG +NYP LT+ PLIGA Sbjct: 95 HEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTPLIGA 154 Query: 126 IAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTG 185 I GN IIKPSE + T+ ++ K++ + + VI GG +E + LL FD IF+TG Sbjct: 155 IIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSHLLSLPFDFIFFTG 214 Query: 186 NTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPD 245 + VGK+VM+AAAKHLTPV LELGGK P + D DLD ++ +GK++N GQT IAPD Sbjct: 215 SPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQTXIAPD 274 Query: 246 YILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEG--QKIAFG 303 Y+ S+++ ++ ++ E VK + E +++ R +R++SLLE ++ G Sbjct: 275 YLYVHYSVKDALLERLVERVKT----ELPEINSTGKLVTERQVQRLVSLLEATQGQVLVG 330 Query: 304 GETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINE-REKPLALY 362 + D + R ++ TV+ V+ +M EE+FGPILP++ +V AI+ +N+ KPLA+Y Sbjct: 331 SQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPKPLAVY 390 Query: 363 VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQ 422 VF + + K +I++ SG N V++H PFGG+G+SGMG YHG S+ TF+H+ Sbjct: 391 VFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFSYLTFTHK 450 Query: 423 RPCLL 427 + + Sbjct: 451 KSVRI 455 >4ZZ7-A nrPDB Length = 501 Score = 413 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 94/465 (20%), Positives = 194/465 (41%), Gaps = 35/465 (7%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E + + AF + R+ P R + + + ++++ +I I + K Sbjct: 45 VEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGKI-------- 96 Query: 61 VITVLGEIDFMLENLPEWVTAKPV------KKNVLTMLDEAYIQPQPLGVVLIIGAWNYP 114 +GE+ +EN+ E+ P +NV +D ++ + QP+GVV I +N+P Sbjct: 97 AHDAMGELQRGIENV-EYACGAPELLKGEHSRNVGPGID-SWSEFQPMGVVAGITPFNFP 154 Query: 115 FVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTEL 173 ++ + AI GN ++KPSE ++ +A+LL + L + V+NG E L Sbjct: 155 VMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDAL 214 Query: 174 LKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 L R + + G+T + + + A+ + G K+ + D D+D ++ Sbjct: 215 LHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGA 274 Query: 233 KYMNCGQTCIAPDYILCEASLQ-NQIVWKIKETVKEFYGEN-IKESPDYERIINLRHFKR 290 + + G+ C+A + + +V K+ + +++ D+ +I +H ++ Sbjct: 275 AFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEK 334 Query: 291 ILSLL-----EGQKIAFGGETD-----EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 ++ + +G I G E ++ T++ V P+ QEEIFGP+L +V Sbjct: 335 VIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVV 394 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFG 400 V + +A++ I+ E +F+ + + + D G V N + + + FG Sbjct: 395 RVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGIN-IPLPVPVAYHSFG 453 Query: 401 GVGSSGMGAYH--GKHSFDTFSHQRPCLLKSLKR--EGANKLRYP 441 G S G H G + ++ ++ + + P Sbjct: 454 GWKRSLFGDLHAYGPDAVRFYTKRKTVTQRWPSAGVREGAEFSMP 498 >5EUY-A nrPDB Length = 491 Score = 413 bits (1062), Expect = e-116, Method: Composition-based stats. Identities = 107/443 (24%), Positives = 206/443 (46%), Gaps = 23/443 (5%) Query: 4 EVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 + +A + + P R + L + + ++ ++D + + + + V+ + V T Sbjct: 51 AIDSAFEALKAWANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVWGEVVFT 110 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA---YIQPQPLGVVLIIGAWNYPFVLTIQ 120 + +++N E A+ + VL E+ + + GVV +I WNYP ++++ Sbjct: 111 -----ERLIQNAAEL--ARHYQGRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSISMK 163 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTE--LLKQR 177 + +A GN V+ KP+ + T ++A+++ + L + ++ ++ G E + +R Sbjct: 164 KIAHTLAVGNTVVYKPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHKR 223 Query: 178 FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 H+ +TG ++ G+ + AA L VTLELGG P I D D+D R + + Sbjct: 224 VAHVTFTGESSTGREIAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQ 283 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENI--KESPDYERIINLRHFKRILSLL 295 GQ C + I+ ++ ++ + + VK ++ E D +IN R + + Sbjct: 284 GQICTSAKRIIVHKAVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMKEFV 343 Query: 296 E-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 + G ++ GG + P + DVD ++M+EE+FGP+ PIV V+N D+A+ Sbjct: 344 DDAVSRGGRLLIGGR--SWGNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVE 401 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 N+ + L+ V ++N R+ + SG NDV + PFGG+ +SG+G Sbjct: 402 VANDTDYGLSGAVLTNNVNRAFRIAEAVESGMFHINDV-TFLEESHVPFGGIKASGVGRE 460 Query: 411 HGKHSFDTFSHQRPCLLKSLKRE 433 G+ SF ++ R + R Sbjct: 461 GGEWSFHETTYDRWVTVTLRTRR 483 >3QAN-A nrPDB Length = 538 Score = 413 bits (1062), Expect = e-116, Method: Composition-based stats. Identities = 98/440 (22%), Positives = 177/440 (40%), Gaps = 20/440 (4%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 E ++ +AF + R+ R L +++ R+ + + + K + + Sbjct: 77 EKAIQSADEAFQTWRNVNPEERANILVKAAAIIRRRKHEFSAWLVHEAGKP-WKEADADT 135 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 121 + +++ + E K + Y P+GV + I WN+ + + Sbjct: 136 AEAIDFLEYYARQMIELNRGKEILSRPGEQNRYFYT---PMGVTVTISPWNFALAIMVGT 192 Query: 122 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFD- 179 + I GN V++KP+ + A ++L L + + + G E + L Sbjct: 193 AVAPIVTGNTVVLKPASTTPVVAAKFVEVLEDAGLPKGVINYVPGSGAEVGDYLVDHPKT 252 Query: 180 -HIFYTGNTAVGKIVMEAAA------KHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 I +TG+ VG + E AA HL V +E+GGK +D+D DLD+ I Sbjct: 253 SLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGGKDTVVVDRDADLDLAAESILVS 312 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI 291 + GQ C A + + ++++ K K G+ +I+ + F++I Sbjct: 313 AFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNLTVGDPTNRDNYMGPVIDEKAFEKI 372 Query: 292 LSLLE----GQKIAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 +S +E ++ GGE D + +I PT++ D+DP+ +MQEEIFGP++ + D Sbjct: 373 MSYIEIGKKEGRLMTGGEGDSSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFD 432 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 A+ N E L V + N I++ E G + N + PFGG SG Sbjct: 433 HALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 407 MGAY-HGKHSFDTFSHQRPC 425 + G + Sbjct: 493 TDSKAGGPDYLALHMQAKTV 512 >3EK1-A nrPDB Length = 504 Score = 405 bits (1042), Expect = e-113, Method: Composition-based stats. Identities = 99/432 (22%), Positives = 178/432 (41%), Gaps = 16/432 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ + +A ++ + R L ++ DI + ++ K E Sbjct: 72 IKEAIDASAKALSGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEARG-E 130 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V+ I++ E + QP+GV I WN+P + + Sbjct: 131 VLYAASFIEWFAEEAKRVYGDTI---PAPQNGQRLTVIRQPVGVTAAITPWNFPAAMITR 187 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQR 177 A+AAG +I++P++L+ TA L L + + + ++ G E L Sbjct: 188 KAAPALAAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTGKAREIGAELTSNDT 247 Query: 178 FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 + +TG+T VG+++M A + ++LELGG +P + D DLD KY N Sbjct: 248 VRKLSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKYRNA 307 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE 296 GQTC+ + I + + ++ K+ VKE G + +I + ++ + +E Sbjct: 308 GQTCVCANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEPGVVIGPMIEEKAITKVKAHIE 367 Query: 297 -----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINF 351 G K+ GG+ + + P +LT V V +EE FGP+ P+ +E I Sbjct: 368 DAVSKGAKLITGGK-ELGGLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQ 426 Query: 352 INEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYH 411 N+ LA Y ++ N R+ + G V N ++ + PFGGV SG+G Sbjct: 427 ANDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEV--APFGGVKQSGLGREG 484 Query: 412 GKHSFDTFSHQR 423 K+ + + + Sbjct: 485 SKYGIEEYLETK 496 >3U4J-A nrPDB Length = 528 Score = 404 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 109/422 (25%), Positives = 194/422 (45%), Gaps = 17/422 (4%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLEN 74 R + + + ++ R++++ + ++ K E+ + Sbjct: 79 WPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQARG-EIGFCADLWSYAAGQ 137 Query: 75 LPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 N + + +P+GVV II WN+PF++ + + AI +G V++ Sbjct: 138 ARALEGQTH---NNIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVL 194 Query: 135 KPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR--FDHIFYTGNTAVGK 191 KPSE + T+ LA+L + + ++ V+ G + ++L + D + +TG+ VG Sbjct: 195 KPSEFTSGTSIRLAELAREAGIPDGVFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGT 254 Query: 192 IVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEA 251 + E AA+ + V LELGGK P + D DLD I +G Y N GQ CI+ +L + Sbjct: 255 KLGEIAARTVKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQE 314 Query: 252 SLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE 305 +++ ++ ++ + ++ +G+ + E +I+ H +++ S + G ++ GGE Sbjct: 315 GIRDALMERLLDISRKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGE 374 Query: 306 T--DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYV 363 EA Y APTV V P + +EEIFGP+L + K DEA+ N E L+ V Sbjct: 375 RIGREAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSASV 434 Query: 364 FSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 +S N + + I +G N VI P GG SG+G G++ FD +S + Sbjct: 435 WSTNLETALQTIRRIRAGRCWINSVIDG--TPELPIGGYKKSGLGRELGRYGFDEYSQFK 492 Query: 424 PC 425 Sbjct: 493 GV 494 >4U3W-A nrPDB Length = 505 Score = 402 bits (1033), Expect = e-112, Method: Composition-based stats. Identities = 104/449 (23%), Positives = 188/449 (41%), Gaps = 27/449 (6%) Query: 1 MELEVRRVRQAFLS-GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQ 59 ++ V+ A + R R L + ++ R + + A AD + + Sbjct: 61 VDSAVQAAHAAQKAGWRDTTPAQRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTL 120 Query: 60 EVITVLGEIDFMLENLP----EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPF 115 ++ + + + E+ + L Y+ +PLGV+ II WN P Sbjct: 121 DIARGIANFRTFADLVRTASGEYFETHAADGSELIN----YVTRKPLGVIGIISPWNLPL 176 Query: 116 VLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVING-GVEETTEL 173 +L + A+A GN V+ KPSE + ++A +LA+++ L ++ +I+G G E Sbjct: 177 LLFTWKVAPALAMGNCVVAKPSEETPSSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEF 236 Query: 174 L--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITW 231 L I +TG + G +M+A A + V+ ELGGK+ + D D D + Sbjct: 237 LTRHPDISAITFTGESRTGSTIMKAVADGVKEVSFELGGKNAAVVFADADFDAAVAGVLR 296 Query: 232 GKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKR 290 + N GQ C+ + + E + + V +KE + G + +I+ H + Sbjct: 297 SSFTNAGQVCLCSERVYVERPIFERFVAALKEQAQALRVGAPEDPATTMGPLISRGHRDK 356 Query: 291 ILSLL-----EGQKIAFGGETD------EATRYIAPTVLTDVDPKTKVMQEEIFGPILPI 339 +LS EG + GG + ++ PT+ T + + ++EEIFGP+ I Sbjct: 357 VLSYFRLAVEEGATVVTGGGAPSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHI 416 Query: 340 VPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPF 399 P + E + +N+ LA +++ R+ + +G V N + PF Sbjct: 417 APFDDEAEVVKRVNDSAYGLAASIWTTQLARGHRVAKQIETGIVWVNAWFVRDL--RTPF 474 Query: 400 GGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428 GG SG+G G+HS D +S ++ Sbjct: 475 GGTKLSGLGREGGRHSLDFYSELTNVCVR 503 >5J77-A nrPDB Length = 508 Score = 398 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 96/444 (21%), Positives = 190/444 (42%), Gaps = 21/444 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ + AF + R + + + ++++ ++ I + K +E Sbjct: 42 VDRAIDAAEDAFWAWNDLGSVERSKIIYRAKELIEKNRAELENIIMEENGKPV-KEAKEE 100 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V V+ +I + E + + V+ Y P G+V+ + WN+P + + Sbjct: 101 VDGVIDQIQYYAEWAR-KLNGEVVEGTSSHRKIFQY--KVPYGIVVALTPWNFPAGMVAR 157 Query: 121 PLIGAIAAGNAVIIKPSELSENTA-KILAKLLPQYLDQDLYIVINGGVEETTELLKQR-- 177 L A+ GN V++KPS + +A I+ K + + + + I G E + + + Sbjct: 158 KLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEHKK 217 Query: 178 FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 + I TG+TA G+ +M+ A+ ++ + LELGGK+P + KD D+D + + W KY N Sbjct: 218 VNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNA 277 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLE- 296 GQ+CIA + + + + + + E ++ + K D +IN + ++E Sbjct: 278 GQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPKN-ADMGPLINKGALQATSEIVEE 336 Query: 297 ----GQKIAFGGETD------EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 G KI FGG + PT++ + D K+K+ QEEIF P++ + +V+ Sbjct: 337 AKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVE 396 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 E + N+ + LA Y+F+ + +I + G + N + G +G Sbjct: 397 EMYDLANDNKYGLASYLFTKDPNIIFEASERIRFGELYVNMPGPEASQGYHT--GFRMTG 454 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSL 430 K+ + + + Sbjct: 455 QAGEGSKYGISEYLKLKNIYVDYS 478 >1T90-A nrPDB Length = 486 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 99/447 (22%), Positives = 197/447 (44%), Gaps = 27/447 (6%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ + +AF + + R + L ++++ + ++++ I + K+ Sbjct: 45 IDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKE----- 99 Query: 61 VITVLGEIDFMLENLPEWVTAKPV-----KKNVLTMLDEAYIQPQPLGVVLIIGAWNYPF 115 LGE+ +EN+ E+ P + EA P+GVV I +N+P Sbjct: 100 ---ALGEVGRGIENV-EFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPM 155 Query: 116 VLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL 174 ++ AIA GN I+KPSE + + L +L + L + ++ V+ G + +L Sbjct: 156 MVPCWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGIL 215 Query: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 I + G+ VG+ V + +++L V G K+ + D +L+ I Sbjct: 216 EHPEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA 275 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL 292 + + G+ C+A + E + ++ + K++E V + G + + +I + KR L Sbjct: 276 FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTL 335 Query: 293 SLL-----EGQKIAFGGETD--EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 S + EG ++ G + + ++ PT+ +V + + ++EIF P+L ++ VKN+ Sbjct: 336 SYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNL 395 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 EAI N+ E +F+ N I+ + +G + N + + + FPF G SS Sbjct: 396 KEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGIN-LGVPAPMAFFPFSGWKSS 454 Query: 406 GMGAYH--GKHSFDTFSHQRPCLLKSL 430 G H GK S D ++ ++ + Sbjct: 455 FFGTLHANGKDSVDFYTRKKVVTARYP 481 >2JG7-A nrPDB Length = 510 Score = 398 bits (1022), Expect = e-111, Method: Composition-based stats. Identities = 96/445 (21%), Positives = 192/445 (43%), Gaps = 20/445 (4%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 E V++ R+A+ P R + + + ++++ K + + ++ ++ K + EV Sbjct: 60 EETVQKTREAWKMWADIPAPKRGEIVRQIGDALRKKIKVLGSLVSLEMGK-IYVEGVGEV 118 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYI-QPQPLGVVLIIGAWNYPFVLTIQ 120 + D+ + + PV + A I Q P+G+V II A+N+P + Sbjct: 119 QEYVDVCDYAVGL--SRMIGGPVLPS--ERPGHALIEQWNPVGLVGIITAFNFPVAVYGW 174 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-----DQDLYIVINGGVEETTELL- 174 A+ GN + K + + T+ + K++ + L + + GG + T + Sbjct: 175 NNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQNNLPGAICSMTCGGADIGTAMAK 234 Query: 175 KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 +R D + +TG+T VGK+V + LELGG + + +D DL++V + Sbjct: 235 DERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGNNAIIVFEDADLNLVVPSAVFASV 294 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILS 293 GQ C ++ S+ + +V +I + K+ G+ S Y + + + L+ Sbjct: 295 GTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIGDPWDPSTLYGPLHTKQAVDQYLA 354 Query: 294 LLE-----GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDE 347 +E G + GG+ D Y+ PT++T + ++ E F PIL ++ K +E Sbjct: 355 AIEQAKQQGGTLVCGGKVMDRPGNYVEPTIITGLAHDAPIVHTETFVPILYVLKFKTEEE 414 Query: 348 AINFINEREKPLALYVFSHNHKLIKRMI-DETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 A + NE ++ L+ +F+ + + R + + S G+ ++ FGG +G Sbjct: 415 AFAWNNEVQQGLSSSIFTKDLGRVFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTG 474 Query: 407 MGAYHGKHSFDTFSHQRPCLLKSLK 431 G G S+ + + C + K Sbjct: 475 GGRESGSDSWKQYMRRSTCTINYSK 499 >2W8P-A nrPDB Length = 487 Score = 396 bits (1019), Expect = e-111, Method: Composition-based stats. Identities = 102/428 (23%), Positives = 185/428 (43%), Gaps = 20/428 (4%) Query: 12 FLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFM 71 F R + R L ++ + + D+ I A+ K + E++ +++ Sbjct: 61 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWF 119 Query: 72 LENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNA 131 E + A + QP+GV +I WN+P + + + A+AAG Sbjct: 120 SEEARRVYGDII---HTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCT 176 Query: 132 VIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGG---VEETTELL--KQRFDHIFYTG 185 V++KP+E + +A LA+L Q + +Y VI +E E + I +TG Sbjct: 177 VVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 236 Query: 186 NTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPD 245 +T GKI++ AA + V++ELGG +P + ++D K+ N GQT + + Sbjct: 237 STTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSN 296 Query: 246 YILCEASLQNQIVWKIKETVKE--FYGENIKESPDYERIINLRHFKRIL-----SLLEGQ 298 L + + + V E +K+ G +E +IN + +++ ++ +G Sbjct: 297 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 356 Query: 299 KIAFGGETDEAT-RYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREK 357 + GG+ + + PT+L +V EE FGP+ P++ +EAI N + Sbjct: 357 TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 416 Query: 358 PLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFD 417 LA Y +S + I R+ ++ G V N+ ++ PFGGV SG+G K+ D Sbjct: 417 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGID 474 Query: 418 TFSHQRPC 425 + + Sbjct: 475 EYLELKYV 482 >3EFV-A nrPDB Length = 462 Score = 395 bits (1015), Expect = e-110, Method: Composition-based stats. Identities = 100/437 (22%), Positives = 176/437 (40%), Gaps = 16/437 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E + F + + R Q L + + ++ +++ I ++ K E Sbjct: 31 IEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMAQCITREMGKPIKQAR-AE 89 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V D+ E+ P + +P L +A I+ +PLGV+L I WN+P ++ Sbjct: 90 VTKSAALCDWYAEHGPAMLNPEPT----LVENQQAVIEYRPLGVILAIMPWNFPLWQVLR 145 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-DQDLYIVINGGVEETTELL-KQRF 178 + + AGN+ ++K + A+++A++L + +Y +N E ++++ R Sbjct: 146 GAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVNANNEGVSQMINDPRI 205 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 + TG+ G + A L LELGG P + D DL++ + G+Y N G Sbjct: 206 AAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNTG 265 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERII-----NLRHFKRIL 292 Q C A + E + + G+ + E D + + H + Sbjct: 266 QVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPMARFDLRDELHQQVQA 325 Query: 293 SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINF 351 S+ EG ++ GG + Y A TVL DV P ++E+FGP+ I K+ A+ Sbjct: 326 SVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFRQELFGPVAAITVAKDAAHALAL 385 Query: 352 INEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYH 411 N+ E L+ +F+ + L M GGV N + FGGV SG G Sbjct: 386 ANDSEFGLSATIFTADDTLAAEMAARLECGGVFING--YSASDARVAFGGVKKSGFGREL 443 Query: 412 GKHSFDTFSHQRPCLLK 428 F + + Sbjct: 444 SHFGLHEFCNVQTVWKN 460 >4OGD-A nrPDB Length = 465 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 90/444 (20%), Positives = 180/444 (40%), Gaps = 17/444 (3%) Query: 5 VRRVRQAFLSGRSRP-LRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 + R + R L R QL + +++ + D+ K F EV Sbjct: 29 LERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGK-LFTEAQGEVDL 87 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLI 123 D+ + E++ + P++ T +AY Q GV+L + WN+P+ ++ Sbjct: 88 CADIADYYADKADEFLMSTPLE----TDSGQAYYLKQSTGVILAVEPWNFPYYQIMRVFA 143 Query: 124 GAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQD--LYIVINGGVEETTELLKQRFDHI 181 GN +++K + + +A+ +L+ + + + + + + + +R + Sbjct: 144 PNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFISYDQVSQVIADKRVVGV 203 Query: 182 FYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTC 241 TG+ G + E A K+L TLELGG I D D D + + + + + N GQ C Sbjct: 204 CLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNAGQVC 263 Query: 242 IAPDYILCEASLQNQIVWKIKETVK-EFYGENIKESPDYERIINLRHFKRILSLLE---- 296 + + ++ + + K +G+ + + + + +L ++ Sbjct: 264 TSSKRFIVLDKDYDRFKELLTKVFKTAKWGDPMDPETTLAPLSSAQAKADVLDQIKLALD 323 Query: 297 -GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINE 354 G ++ +GGE D ++ PT++ + + +EIFGP+ I V + +EAI N+ Sbjct: 324 HGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIEVAND 383 Query: 355 REKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKH 414 L +FS N + K + + +G N L PFGG+ SG G + Sbjct: 384 SNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWTS--LPELPFGGIKHSGYGRELSEL 441 Query: 415 SFDTFSHQRPCLLKSLKREGANKL 438 F +F ++ + + K+ Sbjct: 442 GFTSFVNEHLIYIPNKTNNSNTKV 465 >5X5U-A nrPDB Length = 505 Score = 393 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 95/429 (22%), Positives = 176/429 (41%), Gaps = 16/429 (3%) Query: 9 RQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEI 68 + F + R P R + +V+ER I + + K EV++ I Sbjct: 80 QSGFEAWRKVPAHERAATMRKAAALVRERADAIAQLMTQEQGKPL-TEARVEVLSAADII 138 Query: 69 DFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAA 128 ++ + +N+ + + +P+G V WN+P ++ L A+A Sbjct: 139 EWFADEGRRVYGRIVPPRNLG---AQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALAT 195 Query: 129 GNAVIIKPSELSENT-AKILAKLLPQYLDQDLYIVINGGVEETTELLKQR--FDHIFYTG 185 G + ++K E + + A +L + + + ++ G E + L + +TG Sbjct: 196 GCSFLVKAPEETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTG 255 Query: 186 NTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPD 245 +T VGK + A H+ T+ELGG +P + +D D+ + + K+ N GQ CI+P Sbjct: 256 STPVGKQLASLAGLHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPT 315 Query: 246 YILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE-----GQK 299 L S++++ + + + G ++E + N R + S+++ G Sbjct: 316 RFLVHNSIRDEFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGAS 375 Query: 300 IAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKP 358 I GGE + + APTV+ +V V E FGP+ I ++EAI N Sbjct: 376 IETGGERIGSEGNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFG 435 Query: 359 LALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDT 418 LA Y F+ + + + G + N + PFGGV SG G+ G + + Sbjct: 436 LAGYAFTRSFANVHLLTQRLEVGMLWINQPATPW--PEMPFGGVKDSGYGSEGGPEALEP 493 Query: 419 FSHQRPCLL 427 + + + Sbjct: 494 YLVTKSVTV 502 >4DNG-A nrPDB Length = 485 Score = 393 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 109/441 (24%), Positives = 195/441 (44%), Gaps = 12/441 (2%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E ++A R L+ R + E DI+ IA + + + E Sbjct: 46 LEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIK-STIE 104 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + + +D + E K V ++ ++ Y PLGV+ I +N+P L+++ Sbjct: 105 LEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIY--RLPLGVISSISPFNFPMNLSMR 162 Query: 121 PLIGAIAAGNAVIIKPSELSENTA-KILAKLLPQY-LDQDLYIVINGGVEETTE--LLKQ 176 + AIA GN+V+ KP + + I+AK L + V+ V+E + L Sbjct: 163 SIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTNP 222 Query: 177 RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 236 I +TG+TAVG+ + E A + + LELGG +P + D D+D +GK+++ Sbjct: 223 IPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIH 282 Query: 237 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL 295 GQ C+ + I+ + ++ V K VK+ YG+ +IN R ++ L ++ Sbjct: 283 QGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEII 342 Query: 296 EGQK---IAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFI 352 E K I E + P V D +K+ Q E+F PI I+ + EAI+ Sbjct: 343 EQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMA 402 Query: 353 NEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 N+ E L+ VF+ + + ++ + SG ND ++ + N FGG +SG+G + Sbjct: 403 NDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPN-IAFGGNKASGVGRFGN 461 Query: 413 KHSFDTFSHQRPCLLKSLKRE 433 + F+ + ++ R+ Sbjct: 462 PWVVEEFTVTKWISIQKQYRK 482 >6MVR-A nrPDB Length = 767 Score = 393 bits (1010), Expect = e-109, Method: Composition-based stats. Identities = 98/419 (23%), Positives = 173/419 (41%), Gaps = 26/419 (6%) Query: 9 RQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEI 68 R+A + ++ R + L AL R++Q+ + D K +V Sbjct: 78 RKAQPAW-AKDGAARARVLYALARLLQKHARLFAVLETLDNGKPIREARDIDVPLAQRHF 136 Query: 69 DFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAA 128 T P PLGV + WN+P ++ + A+A Sbjct: 137 YHHAGYAQLMGTEMP--------------DRAPLGVCGQVIPWNFPLLMLAWKIAPALAM 182 Query: 129 GNAVIIKPSELSENTAKILAKLL-PQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNT 187 GN V++KP+E + TA + A + + + ++ G ++ + D + +TG+T Sbjct: 183 GNTVVLKPAEWTPLTALLFADICGQAGVPAGVVNIVTGDGAVGEMIVTAQVDKVAFTGST 242 Query: 188 AVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYI 247 AVG+ + EA A ++LELGGK P + D D+D + + N GQ C A + Sbjct: 243 AVGRRIREATAGTGKALSLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRL 302 Query: 248 LCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGET 306 L + + + K++ + G+ + + D +++ R+ ++ GE Sbjct: 303 LVQEGIADVFHAKLRARMDSLRIGDPLDKCIDIGAMVHPDQLARVRDMVAANT---DGEV 359 Query: 307 DE----ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALY 362 + A Y PT+++ + P + +MQ+EIFGP+L + EA+ N LA Sbjct: 360 YQTAVPAGCYYPPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAAS 419 Query: 363 VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSH 421 V+S N L + + +G V N + + PFGGV SG G G ++ Sbjct: 420 VWSENVNLALDLAPKLVAGIVWING--TNMMDAAAPFGGVRESGFGREGGWEGLAGYTR 476 Score = 83.8 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 66/201 (32%), Gaps = 10/201 (4%) Query: 4 EVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 V + A R Q L + + R + I K + + Sbjct: 544 AVEAMNAA-SGWSRTTGHLRAQILYFIGENLSARADEFANRIKDMTGKDGKAEVAASIDR 602 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLI 123 + + V P++ L M +P+G + I+ P + + + Sbjct: 603 LFSAAA-WADKYDGQVKGVPLRGVALAM-------KEPVGKIGILCPDAAPLLGLVSLMA 654 Query: 124 GAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFDHIF 182 AIA GN V + SE A ++L + + ++ G + E + + D Sbjct: 655 PAIAMGNRVTLAASEAFPLAATDFYQVLDTSDVPAGVVNILTGAHADLAEPMARHLDLDA 714 Query: 183 YTGNTAVGKIVMEAAAKHLTP 203 G + +++ A+A +L Sbjct: 715 VWGLSGHAQVIEAASAGNLKR 735 >3VZ0-A nrPDB Length = 459 Score = 393 bits (1010), Expect = e-109, Method: Composition-based stats. Identities = 98/432 (22%), Positives = 180/432 (41%), Gaps = 17/432 (3%) Query: 6 RRVRQAFLS-GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 R + + + R + R + + +++ + + IA ++ K+ + +E+ Sbjct: 34 DRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDRQHHASLIATEMGKALPD-ALEEIDVT 92 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 + F E++ P+K +A I QPLG++ I WN+P+ + Sbjct: 93 ADILSFYANGAEEFLAPTPLK----VKTGQAKIINQPLGIIYCIEPWNFPYYQLARVAGP 148 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYL-DQDLYIVINGGVEETTELL-KQRFDHIF 182 + AGN VI K + A KL Y I +++ EL+ +R + Sbjct: 149 NLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYANIFLDNDQSAELIKDERIRGVA 208 Query: 183 YTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCI 242 TG+ G+ V A L T+ELGG + D DLD+ + WG++ N GQ C Sbjct: 209 LTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWAVWGRFANNGQVCT 268 Query: 243 APDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL-----SLLE 296 A ++ + + + +K + F G + + + +LR + L ++ Sbjct: 269 AAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRAMELALDQTAEAVKG 328 Query: 297 GQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINER 355 G + GG+ D ++ PT+LTDV V +EIFGP+ + V + AI+ N+ Sbjct: 329 GATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKVASEQAAIDLANDS 388 Query: 356 EKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHS 415 L VFS + +++ ++ +G V N PFGG+ +SG G Sbjct: 389 PYGLGGAVFSRDIARAEKVAEQVETGMVFINTAT--AAAPELPFGGIKNSGFGRELSFLG 446 Query: 416 FDTFSHQRPCLL 427 + F +++ + Sbjct: 447 IEEFINRKLVRI 458 >3VZ3-A nrPDB Length = 457 Score = 393 bits (1009), Expect = e-109, Method: Composition-based stats. Identities = 99/437 (22%), Positives = 184/437 (42%), Gaps = 16/437 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ ++ + ++AF + R R Q LE +++ + ++ K+ E Sbjct: 28 IDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAEIMTTEMGKTH-QSAIAE 86 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + E+ +++ + + T E+Y+ QPLG++L + WN+PF + Sbjct: 87 AEKSALVCRYYAEHGEQFLANEYTE----TQATESYVCYQPLGILLAVMPWNFPFWQVFR 142 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-KQRF 178 A+ AGN ++K + A + +L + ++ + G + +++ R Sbjct: 143 FAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLIGASQVEQVIKDPRV 202 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 TG+ G + A + + P LELGG P + DLD T + MN G Sbjct: 203 KAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAVEVGTVARTMNNG 262 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI-----L 292 Q+ IA + ++ + + K+ G+ + D + + I Sbjct: 263 QSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPLATEGILQDISRQVDQ 322 Query: 293 SLLEGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINF 351 ++ G KI GG D A + PT+LT++ P K++QEE+F P+ + VK++D+AI Sbjct: 323 AVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEELFAPVAMVFTVKDLDQAIAL 382 Query: 352 INEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYH 411 N+ L ++++ +R I E +G V N ++ PFGG SG G Sbjct: 383 ANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVKS--DPRLPFGGTKRSGYGREL 440 Query: 412 GKHSFDTFSHQRPCLLK 428 G TF + + LK Sbjct: 441 GLAGIRTFVNAKTVWLK 457 >3ROS-A nrPDB Length = 484 Score = 392 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 87/450 (19%), Positives = 181/450 (40%), Gaps = 19/450 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ + + R R + L + ++E E ++ + ++ K + +E Sbjct: 28 IDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHEDELAKMMTLEMGKLL-SESKEE 86 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V + ++ ++ PE + + ++ AY Q GV++ WN+P I+ Sbjct: 87 VELCVSICNYYADHGPEMLKPTKLNSDL----GNAYYLKQSTGVIMACEPWNFPLYQVIR 142 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-DQDLYIVINGGVEETTEL-LKQRF 178 GN +++K + +A + AK++ + + I + ++ ++ R Sbjct: 143 VFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLINLYPSYDQLADIIADPRI 202 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCG 238 + TG+ G V EAA K+L T+ELGG + D D ++ + + N G Sbjct: 203 QGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFIVLDDADPQVLRNVLNDARTYNDG 262 Query: 239 QTCIAPDYILCEASLQNQIVWKIKETVKEFY-GENIKESPDYERIINLRHFKRILSLLEG 297 Q C + I+ E S ++++ ++K G+ ++ + + + +++ + ++ Sbjct: 263 QVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDPLEADTTLPPMNSEKAKEKLEAQVKE 322 Query: 298 QKIAFGGET-------DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 I G + D + PT+LTD+ V +E+FGPI + V++ + AI Sbjct: 323 A-IDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNPVFDKEVFGPIAEVFVVEDDNAAIQ 381 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 N+ L V + K++ + +G N T PFGG+ SG G Sbjct: 382 LANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVING--RWITSGELPFGGIKKSGYGRE 439 Query: 411 HGKHSFDTFSHQRPCLLKSLKREGANKLRY 440 F ++ ++ K A L + Sbjct: 440 LSGLGLMAFVNE-HLVIDVTKNNQAENLYF 468 >3RH9-A nrPDB Length = 506 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 103/437 (23%), Positives = 190/437 (43%), Gaps = 19/437 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + V + A P+ R + LE +R ++E ++I + + K + E Sbjct: 51 VVAAVEAGQSALRLTNPWPIETRRKWLEDIRDGLKENREEIGRILCMEHGKP-WKEAQGE 109 Query: 61 VITVLGEIDFMLENLPEWVTAK-PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI 119 V G D+ +++ + P K T + +P+GV +I WN+P + Sbjct: 110 VDYAAGFFDYCAKHISALDSHTIPEKPKDCTWT----VHYRPVGVTGLIVPWNFPIGMIA 165 Query: 120 QPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR- 177 + L A+AAG +IKP+ + T ++ + L + ++ G ++L + Sbjct: 166 KKLSAALAAGCPSVIKPASETPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHK 225 Query: 178 -FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 236 + +TG+T VG+ ++ A+ + + LELGG +P + D DL+ + K+ Sbjct: 226 DVPMLSFTGSTEVGRKLIVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRG 285 Query: 237 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRIL--- 292 GQTC+ + I + + K+ E V + G+ + + D +IN + F ++ Sbjct: 286 GGQTCVCANRIFVHEKVADAFGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHL 345 Query: 293 --SLLEGQKIAFGGETDE--ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 +L +G + G + E + PTV+ VD + QEE FGP++P+ + +E Sbjct: 346 QDALDKGASLVAGKQPAELGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEV 405 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 I+ N+ E LA YVF+ + + +R+ G V N PFGG+ +SG+G Sbjct: 406 IDAGNDTEFGLASYVFTADAERAQRVAAGLRFGHVGWNTGT--GPTPEAPFGGMKASGIG 463 Query: 409 AYHGKHSFDTFSHQRPC 425 G F + Sbjct: 464 REGGLEGLFEFVEAQTV 480 >2QE0-A nrPDB Length = 475 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 100/437 (22%), Positives = 189/437 (43%), Gaps = 16/437 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ ++A + R+ R L + ++ ++ I ++ ++ K + E Sbjct: 42 VDYVYASAKKAQPAWRALSYIERAAYLHKVADILMRDKEKIGAILSKEVAK-GYKSAVSE 100 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDE--AYIQPQPLGVVLIIGAWNYPFVLT 118 V+ I++ E + + A ++ +P+G+VL I +NYP L Sbjct: 101 VVRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLA 160 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR 177 + A+ AGN + KP + +LA+ + L ++ I G E + + + Sbjct: 161 GSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIVEH 220 Query: 178 --FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 + I +TG+T +G+ + + A + P+ L LGGK + +D DL++ + I G + Sbjct: 221 QAVNFINFTGSTGIGERIGKMAG--MRPIMLALGGKDSAIVLEDADLELTAKNIIAGAFG 278 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLL 295 GQ C A +L S+ +++V KI+E V N ++ D +I+ + + L+ Sbjct: 279 YSGQRCTAVKRVLVMESVADELVEKIREKVLALTIGNPEDDADITPLIDTKSADYVEGLI 338 Query: 296 -----EGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 +G E I P + V ++ EE FGP+LPI+ V +V+EAI Sbjct: 339 NDANDKGATALT--EIKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIE 396 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 N+ E L +F+++ + ++ G V N+ T N FPF G SG G Sbjct: 397 ISNKSEYGLQASIFTNDFPRAFGIAEQLEVGTVHINNKTQRGTDN-FPFLGAKKSGAGIQ 455 Query: 411 HGKHSFDTFSHQRPCLL 427 K+S + + + + Sbjct: 456 GVKYSIEAMTTVKSVVF 472 >5N5S-A nrPDB Length = 515 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 94/419 (22%), Positives = 181/419 (43%), Gaps = 15/419 (3%) Query: 22 FRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTA 81 R LE + ++ R ++I + + K + + T+ E++ + Sbjct: 99 ERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDARGEVTRTIDTFQVAAEESVRIYGEH 158 Query: 82 KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141 P+ + + ++ P+G V ++ WN+P L + AIA G ++KP+ + Sbjct: 159 IPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTP 218 Query: 142 NTAKILAKLLP--QYLDQDLYIVINGGVEETTEL-LKQRFDHIFYTGNTAVGKIVMEAAA 198 +A IL ++L + L + ++ E+ + +RF + +TG+ +G + A Sbjct: 219 LSALILGEILHKIEELPLGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARAG 278 Query: 199 KHLTPVTLELGGKSPCYIDKDC-DLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQI 257 K V +ELGG +PC +D DLD +R+ G + GQ+CI + L +++ Sbjct: 279 K--KKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDEV 336 Query: 258 VWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGETDEATR 311 VK+ G +E +I+ K I + +G K+ GG + Sbjct: 337 KEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGG--NRKGA 394 Query: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371 +I PTV+ DV + +EEIFGP++ + + EA+ N L +F+ + Sbjct: 395 FIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNKA 454 Query: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSL 430 + GGV ND ++S P+GG+ SG+ K++ D + +++++ Sbjct: 455 FYAFEHMEVGGVILNDSPA-LRVDSQPYGGLKDSGIQREGVKYAMDDMLETKVLVMRNV 512 >4JZ6-A nrPDB Length = 500 Score = 387 bits (994), Expect = e-108, Method: Composition-based stats. Identities = 94/445 (21%), Positives = 185/445 (41%), Gaps = 24/445 (5%) Query: 4 EVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVIT 63 + +AF + + R + L + +++ + + +A ++ S Sbjct: 62 AAQAAEEAFKTWKDVGPSERRRLLLKVADVMESKTPKFIEVMAMEVGAS----ALWAGFN 117 Query: 64 VLGEIDFMLENLPEWVTAKPVKKNVLTMLDE--AYIQPQPLGVVLIIGAWNYPFVLTIQP 121 V + E + + + + T E + QP+G +L I WN VL + Sbjct: 118 VHASANVFREAAS--LATQIQGETIPTDKAETLSMTLRQPVGPILSIVPWNGTAVLAARA 175 Query: 122 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLK----- 175 + + GN V+ K SE S T ++ + + + L + +N + + E+ Sbjct: 176 IAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAGVLNYLNSSPDRSPEIADALISA 235 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 + I +TG+T VG I+ + AA+HL LELGGKSP + D D++ + +G ++ Sbjct: 236 KEIRRINFTGSTRVGSIIAQKAAQHLKRCLLELGGKSPLIVLDDADINAAVKAAVFGSFL 295 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGEN-IKESPDYERIINLRHFKRILS 293 GQ C++ + ++ + + ++ V + E + G+ + +++ +RI Sbjct: 296 FQGQICMSTERLVVDEKIADEFVARFVEKTERLSVGDPCLTGDCIIGPMVSPNSGERING 355 Query: 294 LL-----EGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 L +G K+ GG + T+L V ++ EE FGPI ++ K EA Sbjct: 356 LFKDAIDKGAKVVCGGMAQ--GAVMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEA 413 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 I N+ L+ VF + R+ G V N + P+GG ++G G Sbjct: 414 IRIANDSVYGLSSGVFGRDINRALRVGMSIEYGCVHINGSTVQN-EAQAPYGGTKNTGYG 472 Query: 409 AYHGKHSFDTFSHQRPCLLKSLKRE 433 + G+ D F+ + ++ +++ Sbjct: 473 RFDGRAVIDEFTELKWLTIEPFEQQ 497 >4YWE-A nrPDB Length = 487 Score = 386 bits (993), Expect = e-108, Method: Composition-based stats. Identities = 106/428 (24%), Positives = 173/428 (40%), Gaps = 18/428 (4%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLEN 74 + R + L L V + +++ A D K + E Sbjct: 66 WGAASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAALAR-----YFEF 120 Query: 75 LPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 + +P GV I WNYP + + + A+AAGNA ++ Sbjct: 121 YAGAADKLHGETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVV 180 Query: 135 KPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR--FDHIFYTGNTAVGK 191 KP+E + + +A+L + L ++ G E L + DHI +TG+ A GK Sbjct: 181 KPAEDACLSVLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATGK 240 Query: 192 IVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEA 251 +V + AA++ PVTLELGGKSP + D DLD + N GQTC A +L E Sbjct: 241 LVTQMAAENHVPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIER 300 Query: 252 SLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQK---------IAF 302 ++ +V ++ + D +IN + +R+ L + Sbjct: 301 AVYEPLVERLATAFNGLRVGPSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQV 360 Query: 303 GGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALY 362 + E+ Y AP +L DV P ++ QEE+FGP+L + + DEA+ N L Sbjct: 361 VADAPESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAG 420 Query: 363 VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQ 422 +++ + R+ +G V N+ + PFGGVG SG G G + F+ Sbjct: 421 IWTRDGARQMRLARRLRAGQVFINNYGAGGGV-ELPFGGVGHSGHGREKGFEALYGFTAL 479 Query: 423 RPCLLKSL 430 + ++ Sbjct: 480 KTIAIRHG 487 >4X0T-A nrPDB Length = 513 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 89/447 (19%), Positives = 183/447 (40%), Gaps = 24/447 (5%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 E V++ R+A+ P R + + + ++E+ + + + ++ ++ K EV Sbjct: 63 EETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGK-ILVEGVGEV 121 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYI---QPQPLGVVLIIGAWNYPFVLT 118 + D+ + ++ + +L + Q P+G+V II A+N+P + Sbjct: 122 QEYVDICDYAVGL------SRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVY 175 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-----DQDLYIVINGGVEETTEL 173 A+ GN + K + + + + K++ + L + + GG + T + Sbjct: 176 GWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAM 235 Query: 174 L-KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 232 +R + + +TG+T VGK V + LELGG + +D DL +V + Sbjct: 236 AKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFA 295 Query: 233 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRI 291 GQ C + S+ +++V ++K+ + G + Y + + Sbjct: 296 AVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMF 355 Query: 292 LSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV 345 L + EG + +GG+ D Y+ PT++T + + E F PIL + KN Sbjct: 356 LGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNE 415 Query: 346 DEAINFINEREKPLALYVFSHNHKLIKRMI-DETSSGGVTGNDVIMHFTLNSFPFGGVGS 404 +E + NE ++ L+ +F+ + I R + + S G+ ++ FGG Sbjct: 416 EEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKH 475 Query: 405 SGMGAYHGKHSFDTFSHQRPCLLKSLK 431 +G G G ++ + + C + K Sbjct: 476 TGGGRESGSDAWKQYMRRSTCTINYSK 502 >5KF0-A nrPDB Length = 485 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 105/432 (24%), Positives = 186/432 (43%), Gaps = 15/432 (3%) Query: 7 RVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLG 66 A R P R L+ +ER ++ A+ + K + + + Sbjct: 57 AAVDAVKPMRELPAYRRQAVLDHCVARFRERFDELAEALCIEAGKPINDSRGEVTRLIDT 116 Query: 67 EIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAI 126 E + ++ + Y + P+G I +N+P L + A+ Sbjct: 117 FRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPAL 176 Query: 127 AAGNAVIIKPSELSENTAKILAKLLPQ-YLDQDLYIVINGGVEETTELL-KQRFDHIFYT 184 AAG ++KP+ + A I+A++L + L + + V+ + +RF + +T Sbjct: 177 AAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGADLFTTDERFRLLSFT 236 Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC--DLDIVCRRITWGKYMNCGQTCI 242 G+ AVG + E A K V LELGG + +D D LD V R+ +G Y GQ+CI Sbjct: 237 GSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSCI 294 Query: 243 APDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE----- 296 IL ASL + + K+ + G+ S +I+ +R+ ++ Sbjct: 295 GVQRILVHASLYDTLRDKLVAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAA 354 Query: 297 GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINERE 356 G KI GG+ D T+L DV + + ++E FGP+ + D+A+ +N+ + Sbjct: 355 GAKIIAGGKVD--GAMFEATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDSD 412 Query: 357 KPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSF 416 L VF+ + +R DE GGV NDV F +++ P+GGV SG+G +++ Sbjct: 413 FGLQAGVFTDSLTHAQRAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYAI 471 Query: 417 DTFSHQRPCLLK 428 + + R +++ Sbjct: 472 EDMTEPRLMVVR 483 >3PRL-A nrPDB Length = 505 Score = 382 bits (982), Expect = e-106, Method: Composition-based stats. Identities = 113/438 (25%), Positives = 191/438 (43%), Gaps = 16/438 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + ++ + A + RP+ R+ L A +++ER++ I I ++ K E Sbjct: 51 VNDAIQGAKDAQKIWKIRPIHERVDLLYAWADLLEERKEIIGELIMHEVAKP-KKSAIGE 109 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDE--AYIQPQPLGVVLIIGAWNYPFVLT 118 V I + + A ++ +PLGVVL I +NYP L Sbjct: 110 VSRTADIIRHTADEALRLNGETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVNLA 169 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-DQDLYIVINGGVEETTELLKQR 177 + A+ GN V+ KP+ + + + L + + V+ G + L + Sbjct: 170 AAKIAPALVTGNTVVFKPATQGSLSGIKMVEALADAGAPEGIIQVVTGRGSVIGDHLVEH 229 Query: 178 --FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 D I +TG T G+ + E A + PV LELGGK P + D DL + +I G + Sbjct: 230 PGIDMITFTGGTTTGERISEKA--KMIPVVLELGGKDPAIVLDDADLKLTASQIVSGAFS 287 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLL 295 GQ C A + + S+ +Q+V IKE V++ + ++ D +I+ + I L+ Sbjct: 288 YSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVGSPEDDADITPVIDEKSAAFIQGLI 347 Query: 296 E-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 + G + G + ++PT+L DV P +V EE FGP+LPI+ VK+ +EAI+ Sbjct: 348 DDALENGATLLSGNKRQ--GNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAIS 405 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 N+ + L +F+ + + G V N + FPF GV SG+G Sbjct: 406 LSNQSDYGLQASIFTKDTDRAINIGKHLEVGTVHINAK-TERGPDHFPFLGVKKSGLGVQ 464 Query: 411 HGKHSFDTFSHQRPCLLK 428 K S + + +R +L Sbjct: 465 GIKPSLLSMTRERVTVLN 482 >5VBF-A nrPDB Length = 478 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 105/436 (24%), Positives = 185/436 (42%), Gaps = 16/436 (3%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ V+ +AF++ R R L + +ER + I I D K E Sbjct: 46 IDAAVQAAHRAFVTWRHESPLVRSDLLRRAAALARERAETIGRHITMDQGKPLRE-AIAE 104 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V++ ++++ E ++ M + +P+GV WN+PF + Sbjct: 105 VVSAAEQLEWHAEEGRRTYGRVVPARSPDVMQT---VLREPIGVCAAFSPWNFPFSQAMH 161 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQR 177 + A+A+G +++K E S + LA+L L ++ G + ++ L + Sbjct: 162 KIAAALASGCTLVLKGPEESPSAIVALAQLFHDAGLPPGCLNIVWGVPGDVSKQLIEAPQ 221 Query: 178 FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 I +TG+ VGK + AA + +T+ELGG +P + D D++ + K+ N Sbjct: 222 VRKISFTGSVPVGKQLAALAASLMKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRNA 281 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL- 295 GQ C++P + + ++ V + V G + + + R I + + Sbjct: 282 GQVCVSPTRFFVQRAAFDRFVCAYLDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFVA 341 Query: 296 ----EGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAIN 350 +G +IA GG Y APTV+ T++M +E FGPI+ IVP ++D+A+ Sbjct: 342 DATAKGAQIATGGMRLPGPGHYFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALA 401 Query: 351 FINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAY 410 N LA Y F+ + + R+ +G V N M PFGGV SG G+ Sbjct: 402 EANRLPFGLASYAFTTSARNAHRISRALEAGMVNINHFGMG--PAEIPFGGVKDSGFGSE 459 Query: 411 HGKHSFDTFSHQRPCL 426 G +FD + + Sbjct: 460 GGMEAFDGYLVTKFVT 475 >6FK3-A nrPDB Length = 536 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 115/466 (24%), Positives = 194/466 (41%), Gaps = 34/466 (7%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + + R+AF P R Q L L ++++ + + + ++ K+ Sbjct: 58 VRKAALKAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEAAGDV 117 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + + F E + P + E + +PLGVV II A N+P + Sbjct: 118 QEAIDTALFFASEGRRLYGQTVPSE----MRDKELFTFRRPLGVVGIITAGNFPIAVPSW 173 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGV-EETTELLKQRF 178 LI A+ GN V+ KPSE + + + AKL + L + V+ GG T + + + Sbjct: 174 KLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELM 233 Query: 179 D-----HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 D +TG+T VG+ + E A ++L TLELGGK+P + +D DLD+ W Sbjct: 234 DEGLFQKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSA 293 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKE-FYGENIK-ESPDYERIINLRHFKRI 291 + GQ C + IL +A + + + E V+ G + Y IN R F R Sbjct: 294 FATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVGNPLLHPEVTYGPFINERFFARW 353 Query: 292 -----LSLLEGQKIAFGGET-------------DEATRYIAPTVLTDVDPKTKVMQEEIF 333 + EG ++ FG EA Y PTV +V P T++ EE+F Sbjct: 354 QEHYRVGEAEGARLLFGRGRITRENPYPRFLGDPEAGLYGWPTVW-EVRPGTRLFTEEVF 412 Query: 334 GPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFT 393 GP + +V V ++EAI N L+ +++++ +G + N+ + Sbjct: 413 GPTINLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVG-A 471 Query: 394 LNSFPFGGVGSSGM-GAYHGKHSFDTFSHQRPCLLKSLKREGANKL 438 PFGGV +SG G G + +++ + R ++ Sbjct: 472 EAHLPFGGVKASGNGGRESGIWVLEEYTYWHAVNEEYSGRLQLAQM 517 >5JRY-A nrPDB Length = 485 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 100/432 (23%), Positives = 182/432 (42%), Gaps = 15/432 (3%) Query: 7 RVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLG 66 A R P R L+ +ER ++ A+ + K + + + Sbjct: 57 AAVDATKPMRELPAYKRQAVLDHCVARFRERFDELAEALCIEAGKPINDAKGEVTRLIDT 116 Query: 67 EIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAI 126 E + ++ + Y + P+G I +N+P L + A+ Sbjct: 117 FRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPAL 176 Query: 127 AAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-KQRFDHIFYT 184 AAG ++KP+ + A I+ ++L + L + + V+ + RF + +T Sbjct: 177 AAGCPFVLKPASRTPVGALIIGEVLAETDLPKGAFSVLPAHRDGADLFTTDDRFRLLSFT 236 Query: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC--DLDIVCRRITWGKYMNCGQTCI 242 G+ AVG + E A K V LELGG + +D D LD V R+ +G + GQ+CI Sbjct: 237 GSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCI 294 Query: 243 APDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE----- 296 IL A + + + K+ + G+ S +I+ +R+ ++ Sbjct: 295 GVQRILAHADIYDALRDKLIAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAA 354 Query: 297 GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINERE 356 G KI GG+ D T+L +V + ++E FGPI + D+A+ +N+ + Sbjct: 355 GAKIVAGGKVD--GAMFEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSD 412 Query: 357 KPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSF 416 L VF+ + ++ DE GGV NDV F +++ P+GGV SG+G +++ Sbjct: 413 FGLQAGVFTDSLAHTQQAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYAI 471 Query: 417 DTFSHQRPCLLK 428 + + R +++ Sbjct: 472 EDMTEPRLLVVR 483 >2J5N-A nrPDB Length = 516 Score = 376 bits (966), Expect = e-104, Method: Composition-based stats. Identities = 99/429 (23%), Positives = 182/429 (42%), Gaps = 18/429 (4%) Query: 12 FLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFM 71 F + + P R + L +++ R++++ + ++ K+ + S +V + I++ Sbjct: 87 FKTWKDWPQEDRSRLLLKAAALMRRRKRELEATLVYEVGKN-WVEASADVAEAIDFIEYY 145 Query: 72 LENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNA 131 + P + V ++ PLG ++I WN+P + ++G +A GN Sbjct: 146 ARAALRY--RYPAVEVVPYPGEDNESFYVPLGAGVVIAPWNFPVAIFTGMIVGPVAVGNT 203 Query: 132 VIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTA 188 VI KP+E + + ++ + + + G EE L R I +TG+ Sbjct: 204 VIAKPAEDAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLE 263 Query: 189 VGKIVMEAAAKH------LTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCI 242 VG + EAA + +E GGK +D+ D D+ + Y GQ C Sbjct: 264 VGLKIYEAAGRLAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCS 323 Query: 243 APDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLE-----G 297 A ++ ++ ++ + + +E+PD +++ +++LS +E G Sbjct: 324 AASRLILTQGAYEPVLERVLKRAERLSVGPAEENPDLGPVVSAEQERKVLSYIEIGKNEG 383 Query: 298 QKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREK 357 Q + G + +IAPTV T+V PK ++ QEEIFGP+L ++ VK+ EA+ N+ Sbjct: 384 QLVLGGKRLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPY 443 Query: 358 PLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHG-KHSF 416 L V+S + ++ E G + N I + PFGG SG A G Sbjct: 444 GLTGGVYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYL 503 Query: 417 DTFSHQRPC 425 F + Sbjct: 504 RLFLEMKAV 512 >5U0M-A nrPDB Length = 497 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 98/429 (22%), Positives = 192/429 (44%), Gaps = 20/429 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ VR R+AFL+ R + L R +EA +++ ++++ I + K + + E Sbjct: 50 VDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESRT-E 108 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V ++G+I ++ E A ++ +P GVV + G +N+P L Sbjct: 109 VAAMMGKIPISVKAYNERTGHTESD----VAGGHAVLRHRPHGVVAVFGPYNFPGHLPNG 164 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR-F 178 ++ A+ AGN V+ KPSEL+ A++ +L + L + ++ GG + L + Sbjct: 165 HIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGLPDGVINLVQGGSDTGKCLARHSLI 224 Query: 179 DHIFYTGNTAVGKIVMEA-AAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 D +F+TG++ VG ++ E + + LE+GG +P + DLD +++ Sbjct: 225 DGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAFLSA 284 Query: 238 GQTCIAPDYILCEASLQ-NQIVWKIKETVKEFYGE--NIKESPDYERIINLRHFKRILS- 293 GQ C +L + ++ + ++ E + P +I+ ++L Sbjct: 285 GQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAEFDADPQPFMGSVISAEAANQLLKA 344 Query: 294 ----LLEGQK-IAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 L +G + + T ++P ++ ++ +E FGP+L + K DEA Sbjct: 345 QAAMLEKGATSLLEMKQLKPDTGLLSPGIVD--ATGIELEDQEFFGPLLTVYRYKGFDEA 402 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 + N L+ + S + KL R+++E +G V N + + ++ PFGGVG+SG Sbjct: 403 LELANNTRYGLSAGILSDDRKLYNRLVEEVRAGIVNWNRPLTGAS-SAAPFGGVGASGNH 461 Query: 409 AYHGKHSFD 417 ++ D Sbjct: 462 RPSAYYAAD 470 >4H7N-A nrPDB Length = 474 Score = 370 bits (951), Expect = e-103, Method: Composition-based stats. Identities = 118/441 (26%), Positives = 206/441 (46%), Gaps = 23/441 (5%) Query: 3 LEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVI 62 + R R+A + + R+ L+ ++ + R + + A+ D + V E+ Sbjct: 32 QQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGRLSITVL--EID 89 Query: 63 TVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPL 122 + L ID PE + ++ + + + P PL V +I WN+P L++ Sbjct: 90 SFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPL--VGVISPWNFPLTLSMIDT 147 Query: 123 IGAIAAGNAVIIKPSELSE-NTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHI 181 I A+ AG AV++KPSE++ A +L L +D+ I + GG E L+ D + Sbjct: 148 IPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRDVLIFVEGGGETGANLINY-VDFV 206 Query: 182 FYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTC 241 +TG+ A G+ V E AA+ P LELGGK P + + +L++ I WG +N GQ+C Sbjct: 207 CFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSC 266 Query: 242 IAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHF----KRILSLLE 296 ++ + I S + ++ + E II + IL +E Sbjct: 267 LSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVE 326 Query: 297 -GQKIAFGGETDE--ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFIN 353 G I GG+ +E + PTV+T+V+ KVM EE FGPI+P++P +V+EA+ N Sbjct: 327 KGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLAN 386 Query: 354 EREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTL-----NSFPFGGVGSSGMG 408 + L+ VF+ + ++ + ++G ++ ND + + N+F F G+G S +G Sbjct: 387 DTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEKNAFNFSGLGGSRVG 446 Query: 409 AYHGKHSFDTFSHQRPCLLKS 429 A F ++ L+K+ Sbjct: 447 A----AGLKRFLRKQAFLIKT 463 >4PXN-A nrPDB Length = 525 Score = 369 bits (947), Expect = e-102, Method: Composition-based stats. Identities = 85/443 (19%), Positives = 181/443 (40%), Gaps = 19/443 (4%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 E +R A + + P R + + + ++ + + ++ ++ K EV Sbjct: 76 EEGMRACFDAAKTWMAIPAPKRGEIVRQIGDALRAKLHHLGRLVSLEMGK-ILPEGIGEV 134 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 121 ++ D+ + + + + M+ E PLGVV +I A+N+P + Sbjct: 135 QEIIDMCDYAVGLSRQLNGSIIPSERPNHMMME---VWNPLGVVGVITAFNFPCAVLGWN 191 Query: 122 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-----DQDLYIVINGGVEETTEL-LK 175 A+ GN V+ K + + + K++ L ++ GG E + L Sbjct: 192 ACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNNLPGAIFTSFCGGTEIGQAIALD 251 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 235 R + +TG+T G +V + + LEL G + + D D+ + R + + Sbjct: 252 IRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNAIIVMDDADIQLAVRSVLFAAVG 311 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSL 294 GQ C ++ ++ + ++ E K+ G+ +++ + + L Sbjct: 312 TAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDPLEKGTLLGPLHTPASKENFLKG 371 Query: 295 L-----EGQKIAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 + +G KI FGG E+ ++ PT++ ++ P V++EE+FGP+L ++ + + EA Sbjct: 372 IQTIKSQGGKILFGGSAIESEGNFVQPTIV-EITPSAPVVKEELFGPVLYVMKFQTLKEA 430 Query: 349 INFINEREKPLALYVFSHNHKLIKRMI-DETSSGGVTGNDVIMHFTLNSFPFGGVGSSGM 407 I N + L+ +F+ +I + + S G+ ++ + FGG ++G Sbjct: 431 IEINNSVPQGLSSSIFTKRPDIIFKWLGPHGSDCGIVNVNIPTNGAEIGGAFGGEKATGG 490 Query: 408 GAYHGKHSFDTFSHQRPCLLKSL 430 G G S+ + + C + Sbjct: 491 GREAGSDSWKQYMRRATCTINYG 513 >5J6B-A nrPDB Length = 485 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 101/429 (23%), Positives = 183/429 (42%), Gaps = 17/429 (3%) Query: 11 AFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDF 70 A R+ P R LE +ER ++ A+ + K N EV ++ Sbjct: 61 AQKPLRALPAFRRQAILEHCVARFRERFDELAQALCIEAGKP-INDSKGEVTRLIDTFRV 119 Query: 71 MLENLPEWVTAKPVKKNVLTMLDEA-YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAG 129 E + + Y + P+G I +N+P L + A+AAG Sbjct: 120 AAEESVRIEGGLVNLEISPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAG 179 Query: 130 NAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-KQRFDHIFYTGNT 187 ++KP+ + A I+ ++L + L + + ++ + +RF + +TG+ Sbjct: 180 CPFVLKPASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGADLFTTDERFKLLSFTGSP 239 Query: 188 AVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCD--LDIVCRRITWGKYMNCGQTCIAPD 245 VG + + A K V LELGG + +D D LD V R+ +G Y GQ+CI Sbjct: 240 TVGWELKKKAGKKK--VVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQ 297 Query: 246 YILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE-----GQK 299 I+ A + + + K+ + G+ + +I+ +R+ +E G K Sbjct: 298 RIIAHADVYDALREKLIAKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAK 357 Query: 300 IAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPL 359 I GG+ D T+L V + ++E FGP+ + + D+A+ +N+ + L Sbjct: 358 IVAGGKVD--GAMFEATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGL 415 Query: 360 ALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419 VF+ + +R DE GGV NDV F +++ P+GGV SG+G +++ + Sbjct: 416 QAGVFTDSLSHAQRAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYAIEDM 474 Query: 420 SHQRPCLLK 428 + R +++ Sbjct: 475 TELRLMVVR 483 >4E4G-A nrPDB Length = 521 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 90/447 (20%), Positives = 178/447 (39%), Gaps = 22/447 (4%) Query: 12 FLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFM 71 + + R + +++ + ++ ++ + K+ + +++ L +F+ Sbjct: 77 QPKWAATNPQRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDD-AKGDIVRGLEVCEFV 135 Query: 72 LENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNA 131 + +P ++ + + Y QP+G+ I +N+P ++ + AIA GNA Sbjct: 136 I-GIPHLQKSEFTEGAGPGIDM--YSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNA 192 Query: 132 VIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL-KQRFDHIFYTGNTAV 189 I+KPSE + LA+L+ + L + V+NG +L + + G+T + Sbjct: 193 FILKPSERDPSVPIRLAELMIEAGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPI 252 Query: 190 GKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYIL- 248 + V AA + G K+ I D DLD + Y + G+ C+A + Sbjct: 253 ARYVYGTAAMNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVP 312 Query: 249 CEASLQNQIVWKIKETVKEFYGEN-IKESPDYERIINLRHFKRILSLLE-----GQKIAF 302 N+++ K+ V+ E D ++ +RI SL++ G K+ Sbjct: 313 VGEETANRLIDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVV 372 Query: 303 GGE-----TDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREK 357 G E +I + DV P + + EIFGP+L +V +N +EA++ + E Sbjct: 373 DGRDFKLQGYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEY 432 Query: 358 PLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA--YHGKHS 415 + +++ + + + G V N V + L FGG SS G HG S Sbjct: 433 GNGVAIYTRDGDAARDFASRINIGMVGVN-VPIPVPLAYHSFGGWKSSSFGDLNQHGTDS 491 Query: 416 FDTFSHQRPCLLKSLKR-EGANKLRYP 441 ++ + + + + P Sbjct: 492 IKFWTRTKTITSRWPSGIKDGAEFSIP 518 >3R64-A nrPDB Length = 508 Score = 366 bits (941), Expect = e-101, Method: Composition-based stats. Identities = 101/440 (22%), Positives = 195/440 (44%), Gaps = 19/440 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ ++A + P R + +++E ++I+ + + + + Sbjct: 52 VDAAYEAAKKAQAEWAATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLE- 110 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 IT+ G I + P V + N E + GVV +I WN+P L+I+ Sbjct: 111 -ITLAGNITKESASFPGRVHGRISPSNTP--GKENRVYRVAKGVVGVISPWNFPLNLSIR 167 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKIL-AKLLPQY-LDQDLYIVINGGVEETTELLKQR- 177 + A+A GNAV+IKP+ + T ++ A++ + + + + G E + Sbjct: 168 SVAPALAVGNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGSEIGDHFVTHA 227 Query: 178 -FDHIFYTGNTAVGKIVMEAA--AKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234 I +TG+T VG+ V E A + V LELGG +P + D D+D + G + Sbjct: 228 VPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAVGAF 287 Query: 235 MNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILS 293 ++ GQ C++ + ++ +A++ ++ + K E VK G+ E +IN + Sbjct: 288 LHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTGDPSAEGTLVGPVINDSQLSGLKE 347 Query: 294 LLE-----GQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 +E G + G + R + P V +DV ++ +EEIFGP++ ++ + A Sbjct: 348 KIELAKKEGATVQVEGPIE--GRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHA 405 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 N + L+ V+S + + + SG V ND+ ++ + FGG +SG+G Sbjct: 406 AELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHINDLTVNDEPHVM-FGGSKNSGLG 464 Query: 409 AYHGKHSFDTFSHQRPCLLK 428 ++G + + F+ R +K Sbjct: 465 RFNGDWAIEEFTTDRWIGIK 484 >3JU8-A nrPDB Length = 490 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 96/421 (22%), Positives = 189/421 (44%), Gaps = 19/421 (4%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ V R+AF + RPL R++ LE ++ R ++ I + K + + E Sbjct: 44 VDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESAT-E 102 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V +++ ++ ++ E + +K+ A ++ +P GVV + G +N+P L Sbjct: 103 VTSMVNKVAISVQAFRE----RTGEKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNG 158 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQDLYIVINGGVEETTELLKQR-F 178 ++ A+ AGN V+ KPSEL+ A++ K + L + ++ GG E L R Sbjct: 159 HIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHRGL 218 Query: 179 DHIFYTGNTAVGKIVMEA-AAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 D +F+TG++ G ++ + + LE+GG +P +++ DLD I +++ Sbjct: 219 DGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISA 278 Query: 238 GQTCIAPDYILCEASLQ-NQIVWKIKETVKEFYGE--NIKESPDYERIINLRHFKRILSL 294 GQ C +L + ++ ++ + + +P +I+L + +L Sbjct: 279 GQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKA 338 Query: 295 LE-----GQK-IAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 E G + + + + + P +L DV + EE FGP+L ++ + A Sbjct: 339 QEHLIGKGAQPLLAMTQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFAAA 397 Query: 349 INFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG 408 I N + LA + S + + ++ + E+ +G V N + +S PFGG+G+SG Sbjct: 398 IREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAA-SSAPFGGIGASGNH 456 Query: 409 A 409 Sbjct: 457 R 457 >4KNA-A nrPDB Length = 495 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 92/423 (21%), Positives = 180/423 (42%), Gaps = 23/423 (5%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E V R+AF + + L R ++ ++ ER++ + T I + K + + E Sbjct: 48 VERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEART-E 106 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 V ++ ++D + E + +K A ++ +P GVV + G +N+P L Sbjct: 107 VASMAAKVDISITAYHE----RTGEKRAPMADGVAVLRHRPHGVVAVFGPYNFPGHLPNG 162 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQR-F 178 ++ A+ AGN V+ KPSEL+ A+ ++ L + ++ G + L R Sbjct: 163 HIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEKDTGVALANHRQI 222 Query: 179 DHIFYTGNTAVGKIVMEAAAKHLTPV-TLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 D +F+TG++ G ++ + V LE+GG +P + + D+D +++ Sbjct: 223 DGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSA 282 Query: 238 GQTCIAPDYILCEASLQ-NQIVWKIKETVKEFYGE--NIKESPDYERIINLRHFKRILSL 294 GQ C IL ++ V ++ + + + P +I+ R R+++ Sbjct: 283 GQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADPQPFMGAVISARAASRLVAA 342 Query: 295 LEGQKIAFGG--------ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD 346 ++ G + D A ++ +L DV ++ EE FGP+ IV ++D Sbjct: 343 Q--ARLVGLGASPIIEMKQRDPALGFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLD 399 Query: 347 EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSG 406 +AI N+ L+ + + + + +G V N + ++ PFGG G SG Sbjct: 400 DAIARANDTAFGLSAGLLADDEQAWHTFRRAIRAGIVNWNR-PTNGASSAAPFGGAGRSG 458 Query: 407 MGA 409 Sbjct: 459 NHR 461 >6DBB-A nrPDB Length = 511 Score = 347 bits (890), Expect = 7e-96, Method: Composition-based stats. Identities = 89/453 (19%), Positives = 186/453 (41%), Gaps = 27/453 (5%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 E ++ AFL R+ P R + + +++E + ++ + + K + EV Sbjct: 53 ERKIDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAELGRLVTLEAGK-ITSEGLGEV 111 Query: 62 ITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 121 ++ DF + + + + E + P+GV +I A+N+P + Sbjct: 112 QEMIDICDFAVGLSRQLYGLTIASERPGHRMMETW---HPIGVCGVISAFNFPVAVWAWN 168 Query: 122 LIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-----------DQDLYIVINGGVEET 170 A G++V+ KPSE + TA LL + L +L ++ G + Sbjct: 169 AALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHPGVAPAELGQLVLGMRDVG 228 Query: 171 TEL-LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRI 229 L ++ + TG+ +G+ V + ++ L LELGG + + DLD+V R + Sbjct: 229 EVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELGGNNGMIVAPSADLDLVVRAV 288 Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHF 288 T+ GQ C ++ SL Q++ +I++ G ++E +++ F Sbjct: 289 TFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYASVKVGNPLEEGTLVGPLVDRASF 348 Query: 289 KRILSLL-----EGQKIAFGGETD---EATRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 + L +G ++ G D Y+ P ++ + ++ V++ E F PIL ++ Sbjct: 349 DAMQKALADAREQGGEVKGGERVDVGHADAYYVRPAIV-RMPKQSAVVERETFAPILYVM 407 Query: 341 PVKNVDEAINFINEREKPLALYVFSHNHKLIKRM-IDETSSGGVTGNDVIMHFTLNSFPF 399 N D+AI+ N + L+ +F+++ + ++ S G+ ++ F Sbjct: 408 VYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMSAAGSDCGIVNVNIGTSGAEIGGAF 467 Query: 400 GGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKR 432 GG +G G G ++ + + + ++ Sbjct: 468 GGEKETGGGRESGSDAWKAYMRRATNTINYSRQ 500 >4I3V-A nrPDB Length = 488 Score = 346 bits (889), Expect = 9e-96, Method: Composition-based stats. Identities = 102/423 (24%), Positives = 182/423 (43%), Gaps = 19/423 (4%) Query: 22 FRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTA 81 R + L A + R+++I I +L S+ + + + + Sbjct: 71 ERQKILLATAEALAARKEEISDVITLELGISKADSLYEVGRAFDVFTLAGQMCIRDDGEI 130 Query: 82 KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSE 141 + + +PL + I +N+P + + AIA N V++KP+EL+ Sbjct: 131 FSCDLTPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTP 190 Query: 142 NTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQRFDHIFYTGNTAVGKIVMEAAA 198 TA +LA +L + L ++ V+ G + + D + +TG+ VGK++ AA Sbjct: 191 MTALLLADILYEAGLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLI--AAN 248 Query: 199 KHLTPVTLELGGKSPCYIDK---DCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255 H LELGG P I D DL G N GQ C A ILC+ S+ + Sbjct: 249 AHYKRQVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVAD 308 Query: 256 QIVWKIKETVKEF-YGENIKESPDYERIINLRHF----KRIL-SLLEGQKIAFGGETDEA 309 + V + E K +G+ + S D +I+ + +R++ + EG I + + Sbjct: 309 RFVPLVLERAKRLRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILY--HPGRS 366 Query: 310 TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA-INFINEREKPLALYVFSHNH 368 + P V+ V ++ ++ EE FGPI+PIV V + D+A I N L+ V ++++ Sbjct: 367 GALLPPIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDY 426 Query: 369 KLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG-AYHGKHSFDTFSHQRPCLL 427 + +++ I G V +V + + PFGG+ SG G + +F++ + L Sbjct: 427 RRMQKYIAGLKVGTVNIWEVP-GYRIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKTFSL 485 Query: 428 KSL 430 Sbjct: 486 PWP 488 >1UXV-A nrPDB Length = 501 Score = 339 bits (871), Expect = 1e-93, Method: Composition-based stats. Identities = 99/426 (23%), Positives = 177/426 (41%), Gaps = 17/426 (3%) Query: 16 RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL 75 R P RL L +++ + + K + EV + + +L Sbjct: 72 RDMPGTERLAVLRKAADIIERNLDVFAEVLVMNAGKP-KSAAVGEVKAAVDRLRLAELDL 130 Query: 76 PEWVTA-KPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVII 134 + P T+ E ++ +PLGVV I +NYP + + + GNAV++ Sbjct: 131 KKIGGDYIPGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVV 190 Query: 135 KPSELSENTAKILAK-LLPQYLDQDLYIVIN-GGVEETTELLKQRFDHIFYTGNTAVGKI 192 KPS A + K LL D ++N G E + R + +TG+T VG+ Sbjct: 191 KPSISDPLPAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTEVGER 250 Query: 193 VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEAS 252 V++ + +ELGG P + +D DLD+ +I G Y GQ C A +L E Sbjct: 251 VVKVGG--VKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERP 308 Query: 253 LQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLLE-----GQKIAFGGET 306 + ++V ++ + + G+ + D +I+ +++ +E G ++ GG Sbjct: 309 VYGKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRR 368 Query: 307 DEATRYIAPTVLTDVDP---KTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYV 363 T Y+ PT++ + + E+F P+ V VK++D+AI N R L V Sbjct: 369 LGPT-YVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAV 427 Query: 364 FSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQR 423 F + I+R + G + ND+ H + +PFGG SG+ ++ + + + Sbjct: 428 FGRDVVKIRRAVRLLEVGAIYINDMPRHG-IGYYPFGGRKKSGVFREGIGYAVEAVTAYK 486 Query: 424 PCLLKS 429 + Sbjct: 487 TIVFNY 492 >4LGZ-A nrPDB Length = 563 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 88/437 (20%), Positives = 162/437 (37%), Gaps = 30/437 (6%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + + A +P+ R Q M+ + +A + V E Sbjct: 102 LNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRR--AEVLAKTMVGQGKTVIQAE 159 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL-GVVLIIGAWNYPFVLTI 119 + IDF N + ++ + + + L G V I +N+ Sbjct: 160 IDAAAELIDFFRFNAK-FAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNF--TAIG 216 Query: 120 QPLIGAIA-AGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--K 175 L GA A GN V+ KPS+ + + + ++L + L ++ + + + Sbjct: 217 GNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSS 276 Query: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229 + I +TG+ K + A++L + E GGK+ ++ D+D V Sbjct: 277 EHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGT 336 Query: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKE--SPDYERIINLRH 287 + GQ C A + SL QI ++ E + E + +I+ + Sbjct: 337 LRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKA 396 Query: 288 FKRILSLLEGQK------IAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 F RI LE + I GG+ +E+ Y+ P ++ DP+ +M+EEIFGP+L + Sbjct: 397 FARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVY 456 Query: 341 PVKNVD--EAINFINERE-KPLALYVFSHNHKLIKRMIDETS--SGGVTGNDVIMHFTLN 395 + E + ++ L VF+ + +++ +G ND + Sbjct: 457 VYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVG 516 Query: 396 SFPFGGVGSSGMGAYHG 412 PFGG +SG G Sbjct: 517 QQPFGGARASGTNDKPG 533 >3V9H-A nrPDB Length = 566 Score = 324 bits (832), Expect = 4e-89, Method: Composition-based stats. Identities = 87/436 (19%), Positives = 162/436 (37%), Gaps = 28/436 (6%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + + A +P+ R Q M+ + +A + V E Sbjct: 105 LNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRR--AEILAKTMVGQGKTVIQAE 162 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 + IDF N V + + + + + G V I +N+ Sbjct: 163 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF--TAIGG 220 Query: 121 PLIGAIA-AGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL--KQ 176 L GA A GN V+ KPS+ + + + ++L + L ++ + + + + Sbjct: 221 NLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 280 Query: 177 RFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRIT 230 I +TG+ K + + A++L + E GGK+ ++ + D++ V Sbjct: 281 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 340 Query: 231 WGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKE--SPDYERIINLRHF 288 + GQ C A + SL QI ++ E + E + +I+ + F Sbjct: 341 RSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 400 Query: 289 KRILSLLEGQ------KIAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341 RI LE I GG+ D++ ++ P ++ DP+ +M+EEIFGP+L + Sbjct: 401 ARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 460 Query: 342 VKN--VDEAINFINERE-KPLALYVFSHNHKLIKRMIDETS--SGGVTGNDVIMHFTLNS 396 + E + ++ L VFS + +++ +G ND + Sbjct: 461 YPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ 520 Query: 397 FPFGGVGSSGMGAYHG 412 PFGG +SG G Sbjct: 521 QPFGGARASGTNDKPG 536 >4OE4-A nrPDB Length = 580 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 93/470 (19%), Positives = 178/470 (37%), Gaps = 53/470 (11%) Query: 15 GRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEID---FM 71 + P R ++ + + +AA + NVY E+ + D + Sbjct: 115 WYNLPFYDRSAIFLKAADLISTKYR--YDMLAATMLGQGKNVYQAEIDCITELSDFFRYY 172 Query: 72 LENLPEWVTAKPVKKNVLTMLDEAYIQPQPL-GVVLIIGAWNYPFVLTIQPLIGAIAAGN 130 ++ + +PV+ T Y +PL G V + +N+ + A+ GN Sbjct: 173 VKYASDLYAQQPVESADGTWNKAEY---RPLEGFVYAVSPFNFTAIAANLIGAPAL-MGN 228 Query: 131 AVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTE--LLKQRFDHIFYTGNT 187 V+ KPS+ + + +L +L + L + + I G + T+ L + F + +TG+T Sbjct: 229 TVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGST 288 Query: 188 AVGKIVM--------EAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQ 239 V K + E + + E GGK+ + ++ G + GQ Sbjct: 289 NVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQ 348 Query: 240 TCIAPDYILCEASLQNQI------------VWKIKETVKEFYGENIKESPDYERIINLRH 287 C A + S + V + + G N++ +I+ + Sbjct: 349 KCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLR--GFMGPVIHEQS 406 Query: 288 FKRILSLLEGQK------IAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIV 340 F +++ ++E K I +GG+ D++ ++ PTV+ P M E FGPIL + Sbjct: 407 FDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVY 466 Query: 341 PVKNVD--EAINFI-NEREKPLALYVFSHNHKLIKRMIDET--SSGGVTGNDVIMHFTLN 395 + + E + I N + L +F+ + K I+ ++ S+G ND ++ Sbjct: 467 EYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVS 526 Query: 396 SFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLK--REGANKLRYPPN 443 FGG SG G + + R +++ K +YP N Sbjct: 527 QQWFGGARMSGTDDKAGGPNILS----RFVSIRNTKENFYELTDFKYPSN 572 >4IDS-A nrPDB Length = 563 Score = 291 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 88/417 (21%), Positives = 160/417 (38%), Gaps = 29/417 (6%) Query: 13 LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFML 72 + P R ++ ++ AA + +VY E+ V IDF Sbjct: 113 SDWAALPFDERAAVFLRAADLLAGPWRE--KIAAATMLGQSKSVYQAEIDAVCELIDFWR 170 Query: 73 ENLPEWVTAKPVKKNVLTMLDE-AYIQPQPL-GVVLIIGAWNYPFVLTIQPLIGAIAAGN 130 N+ + +++ ++ E I +PL G V I +N+ + P A+ GN Sbjct: 171 FNVA--FARQILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGN 227 Query: 131 AVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTE--LLKQRFDHIFYTGNT 187 VI KPS A + +LL L + ++ G ++ L R I +TG+T Sbjct: 228 TVIWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGST 287 Query: 188 AVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTC 241 A + + ++ + E GGK D++ + G + GQ C Sbjct: 288 ATFGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKC 347 Query: 242 IAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDY-ERIINLRHFKRILSLLEGQK- 299 A S+ ++ ++ E +I + +Y +I+ R F + + +E K Sbjct: 348 SAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKG 407 Query: 300 -----IAFGGETDEA-TRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV--DEAINF 351 +A GGE D++ ++ PTVL DP + E FGP+L + + ++ ++ Sbjct: 408 AAAVTVAVGGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDV 467 Query: 352 INE-REKPLALYVFSHNHKLIKRMIDETS--SGGVTGNDVIMHFTLNSFPFGGVGSS 405 I+ L V + + + + +D +G ND + PFGG S Sbjct: 468 IDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 >1EZ0-A nrPDB Length = 510 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 74/413 (17%), Positives = 141/413 (34%), Gaps = 30/413 (7%) Query: 14 SGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLE 73 R R L + ++ R DI+ + E + + E+ ++ + Sbjct: 45 DFRRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVRL-TGEIARTANQLRLFAD 103 Query: 74 -----NLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTI--QPLIGAI 126 + + + P + Q LG V + GA N+P + A+ Sbjct: 104 VVNSGSYHQAILDTPNPTRAPLPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASAL 163 Query: 127 AAGNAVIIKPSELSENTAKILAKLLPQY-----LDQDLYIVINGGVEETTELL--KQRFD 179 AAG VI+K T++I+A+ + Q L Q ++ ++ G + L Sbjct: 164 AAGCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHPEIK 223 Query: 180 HIFYTGNTAVGKIVMEAAAKHLTPV--TLELGGKSPCYIDKDCDLDIV--CRRITWGKYM 235 + +TG+ G+ + A + P+ ELG +P +I + M Sbjct: 224 AVGFTGSVGGGRALFNLAHERPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTM 283 Query: 236 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLL 295 CGQ C P + + + Q ET + S I + +++S Sbjct: 284 GCGQFCTKPGVVFALNTPETQ---AFIETAQSLI-RQQSPSTLLTPGIRDSYQSQVVSRG 339 Query: 296 EGQKIAFGGETDEATRYIAPTVLTDVDP--KTKVMQEEIFGPILPIVPVKNVDEAINFIN 353 I E+ + +T + K +EEIFGP IV +NV + ++ Sbjct: 340 SDDGIDVTFSQAESPCVASALFVTSSENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSE 399 Query: 354 EREKPLALYVFSH--NHKLIKRMIDETS--SGGVTGNDVIMHFTLNS-FPFGG 401 L + + ++ + ++I +G + N + GG Sbjct: 400 MLAGSLTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGYAMVHGG 452 >3V4C-A nrPDB Length = 528 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 68/430 (15%), Positives = 143/430 (33%), Gaps = 36/430 (8%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 + +AF + + R L A+ ++ R + I + + E + + E Sbjct: 65 VNRACEAAEEAFWTYGYSSRKERAAFLRAIADEIEARAEAITEIGSQETGLPEARL-NGE 123 Query: 61 VITVLGEIDFMLENLP-----EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPF 115 G++ +++ + + + E + +P+G V + GA N+P Sbjct: 124 RGRTTGQLRLFADHIEKGDYLDRRVDAAMPERQPAPRQEIRLVQRPVGPVAVFGASNFPL 183 Query: 116 VL--TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD-----QDLYIVINGGVE 168 A+AAG V++K T +I+A+ + + ++ +I GG Sbjct: 184 AFSTAGGDTAAALAAGCPVVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGSR 243 Query: 169 ETTELL--KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTL--ELGGKSPCYIDKDCDLDI 224 + L + +TG+ A G+ + + A P+ ELG +P ++ + L Sbjct: 244 DVGHALVQHPHIKAVGFTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEA-LKA 302 Query: 225 VCRRI----TWGKYMNCGQTCIAPDYILCEASL-QNQIVWKIKETVKEFYGENIKESPDY 279 + M GQ C P + ++ E + + Sbjct: 303 RAETLGQGWAGSLTMGAGQFCTNPGIAVVIEGADADRFTTAAVEALAKV-----APQTML 357 Query: 280 ERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPK---TKVMQEEIFGPI 336 I + + T+ + R +P + + + EE+FGP+ Sbjct: 358 TDGIAKAYRDGQARFATRNAVKPLLATESSGRDASPNLFETTGAQFLADHALGEEVFGPL 417 Query: 337 LPIVPVKNVDEAINFINEREKPLALYVFSH--NHKLIKRMIDETS--SGGVTGNDVIMHF 392 +V V + E + L + + + +R+ +G V N Sbjct: 418 GLVVRVGSPAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVLVNGFPTGV 477 Query: 393 -TLNSFPFGG 401 ++S GG Sbjct: 478 EVVDSMVHGG 487 >5JFN-A nrPDB Length = 524 Score = 181 bits (459), Expect = 7e-46, Method: Composition-based stats. Identities = 72/437 (16%), Positives = 159/437 (36%), Gaps = 59/437 (13%) Query: 19 PLRFRLQQLEALRRMVQERE--KDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLP 76 + R + ++ +R ++ ++ + + + + + + GE +E+L Sbjct: 112 SMSDRARFVQGIRDVILNQDTLEKMSRMAVEETGMGNYE-HKLIKNRLAGEKTPGIEDL- 169 Query: 77 EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKP 136 ++ P GV+ I P + IG +AAGN+V+ P Sbjct: 170 -------TTDAFSGDNGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSP 222 Query: 137 SELSENTAKILAKLLPQYL-----DQDLYIVIN-GGVEETTELL-KQRFDHIFYTGNTAV 189 + + +L +L+ Q L ++L + + +E T ++ + + TG Sbjct: 223 HPRARQVSLLLVRLINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATG---- 278 Query: 190 GKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILC 249 G +++A G P +D+ +++ I G + +A I+ Sbjct: 279 GPAIVKAVLSTGKKAIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIA 338 Query: 250 EASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETD-- 307 A + + +++ +K+ + + + +L+ G + G++ Sbjct: 339 VAQIADYLIFNLKKNGAYEIKD---------PAVLQQLQDLVLTAKGGPQTKCVGKSAVW 389 Query: 308 ---EATRYIAP---TVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLAL 361 + + +L +V + +QEE+ PILP+V V+ VD+AI+ E E Sbjct: 390 LLSQIGISVDASIKIILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIEVEHDNRH 449 Query: 362 YVF--SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMG---------AY 410 S + + + +M F N + G+G+ G G Sbjct: 450 TAIMHSTDVRKLTKMAKLIQ---------TTIFVKNGPSYAGLGAGGEGYSTFTIAGPTG 500 Query: 411 HGKHSFDTFSHQRPCLL 427 G S +F+ +R C++ Sbjct: 501 EGLTSAKSFARRRKCVM 517 >5DBV-A nrPDB Length = 445 Score = 177 bits (450), Expect = 8e-45, Method: Composition-based stats. Identities = 73/448 (16%), Positives = 145/448 (32%), Gaps = 40/448 (8%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 M + ++A L + + R + + A+R+ E + + + Sbjct: 18 MNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETG---------- 67 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQ--PLGVVLIIGAWNYPFVLT 118 + +G + + E D + P GV+ I P Sbjct: 68 -MGNVGHKILKHQLVAEKTPGTEDITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETI 126 Query: 119 IQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY--LDQDLYIVINGGVEETTE---- 172 I IG +A GN V+ P + T+ +L+ + + + T + Sbjct: 127 ICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKI 186 Query: 173 -LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITW 231 + Q I TG G V+ A + G P +D+ D+ I Sbjct: 187 MMSHQDIPLIAATG----GPGVVTAVLQSGKRGIGAGAGNPPVLVDETADIRKAAEDIIN 242 Query: 232 GKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRI 291 G + IA ++ ++ N+++ + + + ++ +I + R Sbjct: 243 GCTFDNNLPAIAEKEVVAIDAIANELMNYMVKEQGCYAITKEQQEKLTNLVITPKGLNRN 302 Query: 292 LSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINF 351 + + + G + I + + + ++ EE+ PIL IV K+ D+A+ Sbjct: 303 C-VGKDARTLLGMIGIDVPSNIRCIIFEG-EKEHPLISEELMMPILGIVRAKSFDDAVEK 360 Query: 352 INEREKPL--ALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVG------ 403 E + ++ S N I + + N FGG G Sbjct: 361 AVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVKNAPSYAAIG----FGGEGFCTFTI 416 Query: 404 SSGMGAYHGKHSFDTFSHQRPCLLKSLK 431 +S G G S TF+ +R C++ Sbjct: 417 ASRTG--EGLTSASTFTKRRRCVMSDSL 442 >5UJU-A nrPDB Length = 576 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 84/442 (19%), Positives = 147/442 (33%), Gaps = 41/442 (9%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQ-- 59 + + A + R + + + +I ++ ++ + Sbjct: 98 DALIAAAAAAQRTWREAGPSAWIGVSLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGG 157 Query: 60 --EVITVLGEIDFMLENLPEWVT----AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNY 113 L + + + L KP KN + + Y P G L++G + Sbjct: 158 PHAQDRALEAVAYAWDQLRRIPADAHWEKPQGKNPPLAMQKRYTI-VPRGTGLVLGCCTF 216 Query: 114 PFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVI----N 164 P L +A GN VI+KP + I ++ D ++ ++ N Sbjct: 217 PTWNGYPGLFADLATGNTVIVKPHPGAILPLAITVRIARDVLREAGFDPNVVTLLATEPN 276 Query: 165 GGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDI 224 G L+ I +TG+T G + A H V E G + ID DL Sbjct: 277 DGALVQDLALRPEIKLIDFTGSTQNGTWLERHA--HQAQVYTEKAGVNQIVIDSTDDLKA 334 Query: 225 VCRRITWGKYMNCGQTCIAPDYILCEAS---------LQNQIVWKIKETVKEFYGENIKE 275 + I + + GQ C AP I +++ I V++ G+ + Sbjct: 335 AAKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDEVAQAIAGAVQKLTGDPARS 394 Query: 276 SPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRY-----IAPTVLT-DVDPKTKVMQ 329 I N RI + ++ +T + + P VL DV + K Q Sbjct: 395 VELIGAIQNDGVTARIDAARAVGRVLLDSQTLQHPAFPDARVRTPLVLQLDVADREKFTQ 454 Query: 330 EEIFGPILPIVPVKNVDEAINFINE--REKP-LALYVFSHNHKLIKRMIDETSSGGV--T 384 E FGPI ++ + ++++ E E L L V+S +I + GGV + Sbjct: 455 -EWFGPISFVIATDSTAQSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGVALS 513 Query: 385 GNDVIMHFTLNSFPFGGVGSSG 406 N F S F +G Sbjct: 514 INLTGGVFVNQSAAFSDFHGTG 535 >5J7I-A nrPDB Length = 488 Score = 150 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 71/417 (17%), Positives = 153/417 (36%), Gaps = 40/417 (9%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 + + A + +E++ +E + + + + + Sbjct: 40 LEEAKAAQKILEKMTQSEIDKIVESMANAAREEAGRLAAMAVEETGFGNVEDKTLKNLFA 99 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 ++ ++++ + ++N + QP+G+V I P I + Sbjct: 100 ANDVYNSIKDVKTVGIIRRDEEN------RVWEIAQPVGIVAGIIPSTNPTSTVIFKALI 153 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYL-----DQDLYI-VINGGVEETTELLKQRF 178 A+ A NA++ P + A+++ + + L + + T EL+K + Sbjct: 154 AVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKGLISCITQPTMAATNELMKHKL 213 Query: 179 -DHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 D I TG G +++AA P G P YI + ++ + I K + Sbjct: 214 TDVILATG----GPGLVKAAYSSGKPAYGVGPGNVPVYIHESANIAKAVQLIIQSKTFDY 269 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEG 297 G C + +L + S++ ++V ++K+ F E K+ ++N +I+ + Sbjct: 270 GTICASEQALLVDESIKEKVVAELKQQGAYFLNEEEKQKVASIIMVNGSLNAKIVG--KA 327 Query: 298 QKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIF-----GPILPIVPVKNVDEAINFI 352 ++ + A I V V +T+V +E F PIL VK ++EA Sbjct: 328 PQVIA----EMAGIEIPSDVKLLVAEETEVGKEYPFSIEKLSPILAFYIVKGMEEASELA 383 Query: 353 NE--REKPLAL--YVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSS 405 + L + + + K+I+ + +G + N FGG+G++ Sbjct: 384 QKLLEVGGLGHTVGIHAEDEKVIEAYTIDKPAGRIVVNAGTT--------FGGIGAT 432 >2Y53-A nrPDB Length = 534 Score = 148 bits (373), Expect = 7e-36, Method: Composition-based stats. Identities = 54/400 (13%), Positives = 142/400 (35%), Gaps = 39/400 (9%) Query: 16 RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL 75 R+ R +L + +++Q + D A+ + N + ++ + + + + Sbjct: 61 RALTYAQRAARLADIVKLLQAKRGDYYAIATANSG-TTRNDSAVDIDGGIFTLSYYAKLG 119 Query: 76 PEWVTAKPVKKNVLTMLDE------AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAG 129 ++ L + ++ GV L I A+N+P + A+ +G Sbjct: 120 ASLGEVHALRDGSAESLSKDRSFSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALLSG 179 Query: 130 NAVIIKPSELSE-NTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQRFDHIFYTGNT 187 VI+KP+ + T +++A ++ L +I G + + + FD + +TG+ Sbjct: 180 VPVIVKPATATAWLTQRMVADVVDAGILPPGALSIICGSSAGLLDQI-RSFDVVSFTGSA 238 Query: 188 AVGKIVMEAAA--KHLTPVTLELGGKSPCYIDKDCD-----LDIVCRRITWGKYMNCGQT 240 + A + + ++ + + D D+ + + + GQ Sbjct: 239 DTAATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKSGQK 298 Query: 241 CIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL---- 295 C A + ++ +K + + G ++ +++ ++ +L+ + Sbjct: 299 CTAIRRAFVPEAALEPVLEALKAKLAKITVGNPRNDAVRMGSLVSREQYENVLAGIAALR 358 Query: 296 EGQKIAFGGET-------DEATRYIAPTVL-TDVDPKTKVMQE-EIFGPILPIVPVK--- 343 E +A+ +AP + + ++ + E+FGP+ + P + Sbjct: 359 EEAVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPYRVTT 418 Query: 344 -----NVDEAINFINEREKPLALYVFSHNHKLIKRMIDET 378 A+ + L ++S++ + R+ E Sbjct: 419 DTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALEL 458 >6D97-A nrPDB Length = 547 Score = 128 bits (323), Expect = 5e-30, Method: Composition-based stats. Identities = 72/389 (18%), Positives = 134/389 (34%), Gaps = 40/389 (10%) Query: 40 DILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAK-PVKKNVLTMLDEAYIQ 98 D + + + EV ++ + ++ V N L Y Sbjct: 128 DFFAKLIQRVSPKSYQQALAEVQVSQKFLENFCGDQVRFLARSFAVPGNHLGQRSNGY-- 185 Query: 99 PQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ-YLDQ 157 P G V II +N+P + + L+GA+ GN ++K + + +LL L Sbjct: 186 RWPYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLKVDSKVSIVMEQMIRLLHDCGLPA 245 Query: 158 DLYIVINGGVEETTELLKQ-RFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYI 216 + IN +LL + +TG++ V + + AA V LE G + Sbjct: 246 EDMDFINSDGAVMNKLLLEANPKMTLFTGSSRVAEKL---AADLKGRVKLEDAGFDWKIL 302 Query: 217 DKDC-DLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKE 275 D ++D V Y GQ C A + + + + E +K+ E Sbjct: 303 GPDVQEVDYVAWVCDQDAYACSGQKCSAQSVLFMHKNWSS---SGLLEKMKKLSERRKLE 359 Query: 276 SPDYERIIN------LRHFKRILSLLEGQKIAFGGET------DEATRYIAPT-VLTDVD 322 ++ + H +L + G K+ FGGE + + PT V ++ Sbjct: 360 DLTIGPVLTVTTEAMIEHMNNLLK-IRGSKVLFGGEPLANHSIPKIYGAMKPTAVFVPLE 418 Query: 323 P-----KTKVMQEEIFGPILPIVPVKNVD-----EAINFINEREKPLALYVFSHNHKLIK 372 +++ +EIFGP + EA +N L + S++ ++ Sbjct: 419 EILKSGNFELVTKEIFGPFQVVTEYSEDQLELVLEACERMNAH---LTAAIVSNDPLFLQ 475 Query: 373 RMIDETSSGGVT-GNDVIMHFTLNSFPFG 400 ++ + +G G + FG Sbjct: 476 DVLGRSVNGTTYAGIRARTTGAPQNHWFG 504 >3MY7-A nrPDB Length = 452 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 59/416 (14%), Positives = 135/416 (32%), Gaps = 34/416 (8%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 ++ + RV++A + + ++ ++ + + + L A + Sbjct: 9 LDAMIARVKKAQEEFATYS-QEQVDKIFRAASLAANQARIPLAQQAVEESGMGIVEDKVI 67 Query: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 120 E + + E + + L + A +P+G++ I P I Sbjct: 68 KNHFASEFIYN-KYKDEQTCGILEEDDNLGTMTIA----EPVGIICGIVPTTNPTSTAIF 122 Query: 121 PLIGAIAAGNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVI-NGGVEETTELL 174 + ++ N +I P ++N+ AKL+ +D+ I VE + L+ Sbjct: 123 KSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSVELSNALM 182 Query: 175 KQR-FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233 K I TG G +++AA P G P ID+ D+ + K Sbjct: 183 KHDDIALILATG----GPGMVKAAYSSGKPAIGVGAGNVPVVIDETADIKRAVASVLMSK 238 Query: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILS 293 + G C + ++ + +++ + + + +I+ +I+ Sbjct: 239 TFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVLSKTDADKVRKVLLIDGALNAKIVG 298 Query: 294 -----LLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEA 348 + E G + T+ + L V E++ P L + N ++A Sbjct: 299 QPATAIAEMA----GVKVPADTKVLIGEGLGKVSYDDAFAHEKL-SPTLGMFRADNFEDA 353 Query: 349 INFINERE----KPLALYVFSH---NHKLIKRMIDETSSGGVTGNDVIMHFTLNSF 397 + ++++ N I+ D+ + + N H + Sbjct: 354 VAQAVTMVEIGGIGHTSGLYTNQDVNADRIRYFGDKMKTARILINIPTTHGGIGDL 409 >3K9D-A nrPDB Length = 464 Score = 114 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 50/413 (12%), Positives = 130/413 (31%), Gaps = 41/413 (9%) Query: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64 + +A + + ++A+ + + + + + + Sbjct: 18 IESANKAQKELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGIWQDKVIKNVFA 77 Query: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124 + ++++ K + + + PLGVV + P I + Sbjct: 78 SKHVYNYIKDMKTIGMLKEDNEKKVMEVA------VPLGVVAGLIPSTNPTSTVIYKTLI 131 Query: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQY-----LDQDLYI-VINGGVEETTELLKQR- 177 +I AGN+++ P + +++ + + + ++ T +L+K + Sbjct: 132 SIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTDQLMKHKD 191 Query: 178 FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNC 237 I TG G +++AA TP G P +I++ ++ + I K + Sbjct: 192 TAVILATG----GSAMVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHILDSKTFDN 247 Query: 238 GQTCIAPDYILCEASLQNQIVWKIKETVKEFYGEN---------IKESPDYERIINLRHF 288 G C + ++ E + ++ + ++ F + ++ + I + Sbjct: 248 GTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMNPAIVGKSV 307 Query: 289 KRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKV-MQEEIFGPILPIVPVKNVDE 347 + I +L G + + + K+ E PIL + E Sbjct: 308 QHIANLA-GLTVPADARV---------LIAEETKVGAKIPYSREKLAPILAFYTAETWQE 357 Query: 348 AINFINEREK----PLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNS 396 A + L + S + ++I+ + + N + + Sbjct: 358 ACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNTPGALGGIGA 410 >1O20-A nrPDB Length = 427 Score = 109 bits (273), Expect = 3e-24, Method: Composition-based stats. Identities = 75/453 (16%), Positives = 160/453 (35%), Gaps = 71/453 (15%) Query: 1 MELEVRRVRQAFLSG---RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVY 57 M+ + + ++ + R+ R + + ++ + + ER K+IL A D+ K+ Sbjct: 13 MDELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGV 72 Query: 58 SQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQ---------PQPLGVVLII 108 + ++ L D ++ + + K+ + + +++++ P+G + II Sbjct: 73 KESLVDRLALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGII 132 Query: 109 ---GAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL-----DQDLY 160 +T++ I A+ +GN ++++ + N+ K + + + L + Sbjct: 133 YESRP-----NVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSV 187 Query: 161 IVI-NGGVEETTEL--LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG-GKSPCYI 216 I N E+ L++ + G ++ + T LE G G ++ Sbjct: 188 EFIENTDRSLVLEMIRLREYLSLVI----PRGGYGLISFVRDNATVPVLETGVGNCHIFV 243 Query: 217 DKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKES 276 D+ DL I K G TC A + +L + + + I E ++ Sbjct: 244 DESADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELR---------- 292 Query: 277 PDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPI 336 +H + + ++I P V+ + E I Sbjct: 293 ---------KHGVEVRGCEKTREIV-------------PDVVPATEDD---WPTEYLDLI 327 Query: 337 LPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNS 396 + I VKNVDEAI I + + + + N+ K+ + E + V N Sbjct: 328 IAIKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVNASTRFTDGGQ 387 Query: 397 FPFGGVGSSGMGAYH--GKHSFDTFSHQRPCLL 427 F FG +H G + + +L Sbjct: 388 FGFGAEIGISTQRFHARGPVGLRELTTYKFVVL 420 >4GHK-A nrPDB Length = 444 Score = 85.3 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 75/411 (18%), Positives = 131/411 (31%), Gaps = 73/411 (17%) Query: 25 QQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPV 84 LEA+ R ++ + A A D+ +++ + L D L+ + E + Sbjct: 52 AALEAVARAIERDAGALKAANARDVARAKDKGLDAAFVDRLTLSDKALKTMVEGLRQVAT 111 Query: 85 KKNVLTMLDEAYIQ---------PQPLGVVLII---GAWNYPFVLTIQPLIGAIAAGNAV 132 + + + + PLGV+ II +TI + +GNA Sbjct: 112 LPDPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRP-----NVTIDAAALCLKSGNAT 166 Query: 133 IIKPSELSENTAKILAKLL-----PQYLDQDLYIVI-NGGVEETTEL--LKQRFDHIFYT 184 I++ + + LAKL+ L QD V+ L + + D I Sbjct: 167 ILRGGSEALESNTALAKLIGEGLAEAGLPQDTVQVVETADRAAVGRLITMTEYVDVIV-- 224 Query: 185 GNTAVGKIVMEAA-AKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIA 243 GK ++E + P+ L G Y+D + K G TC Sbjct: 225 --PRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASVTKALTVCDNAKTHRYG-TCNT 281 Query: 244 PDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFG 303 + +L + ++ + R+ + + + + Sbjct: 282 METLLVARGIAPAVLSPL------------------GRLYREKGVELRVDADARAVLEAA 323 Query: 304 GETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLAL-- 361 G + P VD + + E P+L I V +D AI IN E Sbjct: 324 G--------VGPL----VDATDEDWRTEYLAPVLAIKIVDGIDAAIEHIN--EYGSHHTD 369 Query: 362 YVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHG 412 + + +H R + E S V N + F F G+GA G Sbjct: 370 AIVTEDHDRAMRFLREVDSASVMVNASTRFA--DGFEF------GLGAEIG 412 >4JBE-A nrPDB Length = 445 Score = 80.7 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 60/408 (14%), Positives = 127/408 (31%), Gaps = 67/408 (16%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E R + A S P LE++ + +L A A D+ K+E S Sbjct: 41 VEECARAAKSAAPSLSGAPDTAIDAALESMADRLLAHRDAVLAANAEDIAKAEAGGMSAG 100 Query: 61 VITVLGEIDFMLENLPEWVT--------AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWN 112 ++ L + L ++ + + + V+ + L + +P+GV+ N Sbjct: 101 LLDRLTITESRLTDMADQLRLLAGAPHPQRTVELSTLDGGLRLVERRRPVGVIGA----N 156 Query: 113 YPF--VLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLL------PQYLDQDLYIVIN 164 Y +T+ + + NA +++ + +A+ L +++ +D ++ ++ Sbjct: 157 YEARPNVTVDVASQLVKSRNAGVLRTGSAALKSAQRLLEVVIRPALTDSGIDANVVQLVP 216 Query: 165 GGVEETTELLKQRFDHIFYT---GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCD 221 E L + D + G+ + + AA+H G Y+D+ D Sbjct: 217 RPEREAAGALVRLPDLVPLVILRGSGESTRALALEAAQHGVRTLAHADGGGVLYVDEKAD 276 Query: 222 LDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYER 281 D R + G C + +L ++ + + E + E Sbjct: 277 RD-TVRSLVVNSLDRLG-VCNRLNLLLIHDAVYEEFWPVVSEALAERGVSPSLP-----P 329 Query: 282 IINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341 + ++ L + + Sbjct: 330 YDHPIGYEWALDSEREATV-------------------------------------TVAR 352 Query: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVI 389 V V EA+ NE LA + + + + + D GV N Sbjct: 353 VDGVAEAVRIANEETSGLAAGIATEDARAAEEFFDGYQGTGVFWNAPT 400 >2H5G-A nrPDB Length = 463 Score = 69.9 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 78/433 (18%), Positives = 162/433 (37%), Gaps = 76/433 (17%) Query: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60 +E + R + R + + L ++ ++ +IL A DL ++E + + Sbjct: 31 VEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAAPL 90 Query: 61 VITV------LGEIDFMLENLPE---WVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAW 111 + + L + L + + +++ + E P+GV+L+I Sbjct: 91 LKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVI--- 147 Query: 112 NY---PFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLD----QDLYIVIN 164 + P L Q AIA+GN +++K + + ++ +IL L + L ++ ++N Sbjct: 148 -FESRPDCLP-QVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVN 205 Query: 165 GGVEETTEL--LKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDL 222 EE +L L + D I G++ + + + +AA PV G Y+D + + Sbjct: 206 -TREEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAA--KGIPVMGHSEGICHMYVDSEASV 262 Query: 223 DIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI 282 D V R + K C A + +L ++ +P +++I Sbjct: 263 DKVTRLVRDSKCEYPA-ACNALETLLIHR--------------------DLLRTPLFDQI 301 Query: 283 INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPI-LPIVP 341 I++ +++ KI G + + + K ++ E +G + L I Sbjct: 302 IDMLRVEQV-------KIHAGPKFASYLTF--------SPSEVKSLRTE-YGDLELCIEV 345 Query: 342 VKNVDEAINFINEREKPLALY--VFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPF 399 V NV +AI+ I + + + + + + + S V N F+ Sbjct: 346 VDNVQDAIDHI--HKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWN-ASTRFSDGY--- 399 Query: 400 GGVGSSGMGAYHG 412 G+GA G Sbjct: 400 ----RFGLGAEVG 408 >1VLU-A nrPDB Length = 468 Score = 64.1 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 74/442 (16%), Positives = 146/442 (33%), Gaps = 76/442 (17%) Query: 2 ELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 61 + + R+A ++ R L + ++ I A DL ++ + + Sbjct: 17 QQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSL 76 Query: 62 ITVLG-----EIDFMLENLPEWVT-AKPVKK-NVLTMLDEAYIQPQ---PLGVVLIIGAW 111 + L + + ML+ + + PV K + LD+ Q P+GV+L+I + Sbjct: 77 LKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVI--F 134 Query: 112 NYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQ---------YLDQDLYIV 162 + +I +GNA I+K + S NT + +AK++ + + Sbjct: 135 ESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQL 194 Query: 163 INGGVEETTELLKQR--FDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDC 220 I ++ ++LL Q D + G+ A+ + + + PV G Y+D+D Sbjct: 195 IE-TRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDTTK---IPVLGHADGICSIYLDEDA 250 Query: 221 DLDIVCRRITWGKYMN-CGQTCIAPDYILCEASL--QNQIVWKI-------KETVKEFYG 270 DL R K G C A + +L +++ + K+ Sbjct: 251 DLIKAKRISLDAKTNYPAG--CNAMETLLINPKFSKWWEVLENLTLEGGVTIHATKDLKT 308 Query: 271 ENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQE 330 + + ++ ++ + + E D ++ +D K Sbjct: 309 AYFDKLNELG---------KLTEAIQCKTVDADEEQDFDKEFL------SLDLAAKF--- 350 Query: 331 EIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIM 390 V + + AI IN + + N ++ + S GV N Sbjct: 351 -----------VTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWNASTR 399 Query: 391 HFTLNSFPFGGVGSSGMGAYHG 412 G G GA G Sbjct: 400 FAD-------GFRY-GFGAEVG 413 >1PDZ-A nrPDB Length = 434 Score = 34.9 bits (79), Expect = 0.072, Method: Composition-based stats. Identities = 23/144 (15%), Positives = 47/144 (32%), Gaps = 15/144 (10%) Query: 147 LAKLLPQYLDQDLYIVINGGVEETTELLKQRF-----DHIFYTGNTAVGKIVMEAAAKHL 201 LA L + VINGG +L Q F +T +G V + Sbjct: 137 LANYDEVILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMRMGTEVYHHLKAVI 196 Query: 202 T-------PVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCI--APDYILCEAS 252 + GG +P ++ LD++ I Y + + A + + Sbjct: 197 KARFGLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGYTGKIEIGMDVAASEFYKQNN 256 Query: 253 LQN-QIVWKIKETVKEFYGENIKE 275 + + + ++ G+ +++ Sbjct: 257 IYDLDFKTANNDGSQKISGDQLRD 280 >5MMM-i nrPDB Length = 208 Score = 31.4 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 7/67 (10%), Positives = 24/67 (35%), Gaps = 6/67 (8%) Query: 212 SPCYIDKDCDLDIVCRRITWGKY-----MNCGQTCIAPDYILCEASLQNQIVWKIKETVK 266 +P + + DL+ + G + + G+ A ++ + + + ++ + Sbjct: 56 APVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIARVVLQEGTG-KFIINYRDAKE 114 Query: 267 EFYGENI 273 G + Sbjct: 115 YLQGNPL 121 >2XH7-A nrPDB Length = 443 Score = 31.0 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 19/93 (20%), Positives = 25/93 (26%), Gaps = 14/93 (15%) Query: 154 YLDQDLYIVINGGVEETTELLKQRFDHIFYTGNT------AVGKIVMEAAAKHLTPVTLE 207 L V+NGG L Q F I TG +G V Sbjct: 145 VLPVPFLNVLNGGSHAGGALALQEF-MIAPTGAKTFAEALRIGSEVYHNLKSLTKKRYGA 203 Query: 208 L-------GGKSPCYIDKDCDLDIVCRRITWGK 233 GG +P + LD++ I Sbjct: 204 SAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAG 236 >5X8R-i nrPDB Length = 157 Score = 31.0 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 7/67 (10%), Positives = 24/67 (35%), Gaps = 6/67 (8%) Query: 212 SPCYIDKDCDLDIVCRRITWGKY-----MNCGQTCIAPDYILCEASLQNQIVWKIKETVK 266 +P + + DL+ + G + + G+ A ++ + + + ++ + Sbjct: 5 APVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIARVVLQEGTG-KFIINYRDAKE 63 Query: 267 EFYGENI 273 G + Sbjct: 64 YLQGNPL 70 >6C49-A nrPDB Length = 350 Score = 30.6 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 40/119 (33%), Gaps = 27/119 (22%) Query: 137 SELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEA 196 S L+ N + L + + + +I+G T TG+ A + +++ Sbjct: 259 STLAPNGSLHFLGLTLEPVPVSVGSLIDGAKSVTGSP----------TGSPAALRQLLKF 308 Query: 197 AAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255 AA+ +EL L+ R+ + GQ A I+ +A Sbjct: 309 AARKKIAPQIEL--------FPMSQLNEAIERL------HSGQ---ARYRIVLKADFAE 350 >4G1B-A nrPDB Length = 399 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 22/112 (19%), Positives = 38/112 (33%), Gaps = 14/112 (12%) Query: 239 QTCIAPDY-ILCEASLQNQIVWKIKETVKEFYGENIKES-----PDYERIINLRHFKRIL 292 Q P+ I S ++ K+ V E E D E +IN K Sbjct: 294 QVKCNPNRPIYWIQSSYDEKTQAFKKHVDELLAECANVDKIIVHTDTEPLINAAFLKE-K 352 Query: 293 SLLEGQKIAFGGETDEATRYIAPTV--LTDVDPKTKVMQEEIFGPILPIVPV 342 S G + ++ + L +++ + ++ E FGP + V V Sbjct: 353 SPAHADVYTCG-----SLAFMQAMIGHLKELEHRDDMIHYEPFGPKMSTVQV 399 >3LOO-A nrPDB Length = 365 Score = 29.5 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 19/49 (38%), Gaps = 8/49 (16%) Query: 330 EEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDET 378 EEIF P + ++ N EAI E + + + I + I Sbjct: 226 EEIF-PYVDVL-FGNETEAIALAKEFNYG------TEDLREIGKRIAAL 266 >2R70-A nrPDB Length = 852 Score = 29.1 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 19/52 (36%), Gaps = 3/52 (5%) Query: 70 FMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQP 121 F P+ V K +K V ++ + L +V WNYP + Sbjct: 601 FCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGG---WNYPLLNKACK 649 >1EU1-A nrPDB Length = 780 Score = 28.7 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 42/118 (35%), Gaps = 23/118 (19%) Query: 210 GKSPCYIDKDCDLDIVCRRITWG----KYMNCGQTCIAPDYILCEASLQNQIVWKIKETV 265 G PC I+ D R I G + + GQ IL A + + ++ + Sbjct: 665 GHEPCLINP---ADAAARGIADGDVLRVFNDRGQ-------ILVGAKVSDAVMPGAIQIY 714 Query: 266 KEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDP 323 + + + + S + ++ +LSL G G + T+L DV+ Sbjct: 715 EGGWYDPLDPSEE--GTLDKYGDVNVLSLDVGTSKLAQGNCGQ-------TILADVEK 763 >2Y5N-A nrPDB Length = 417 Score = 28.7 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 16/106 (15%), Positives = 34/106 (32%), Gaps = 3/106 (2%) Query: 6 RRVRQAFLSGRSRPLRFRLQQLEALRRMV---QEREKDILTAIAADLCKSEFNVYSQEVI 62 QA+ R R + + L + ++++ + DL + Sbjct: 201 EAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTT 260 Query: 63 TVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLII 108 T + + ++L PE + ++ E + PLGV Sbjct: 261 TQIADFVYLLMTRPELRRQLLDRPELIPSAVEELTRWVPLGVGTAF 306 >5W7R-A nrPDB Length = 429 Score = 28.7 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 18/63 (28%), Positives = 23/63 (36%), Gaps = 4/63 (6%) Query: 302 FGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV---KNVDEAINFINEREKP 358 G E T + + D+ VM IFGP+L I N +AI N Sbjct: 149 VGEEEYAHTPFSEAYLTADIAGCFPVMSNFIFGPVLQICDFLRQNNWKDAITTRNN-PFT 207 Query: 359 LAL 361 LA Sbjct: 208 LAH 210 >2IPH-A nrPDB Length = 181 Score = 28.7 bits (63), Expect = 6.6, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 13/33 (39%), Gaps = 1/33 (3%) Query: 308 EATRYIAPTVLTDVDPKTKVMQEEIFG-PILPI 339 +++PTV +E FG P+ I Sbjct: 15 GWGFWVSPTVFITTTHVIPTSAKEFFGEPLTSI 47 >3C3E-A nrPDB Length = 311 Score = 28.3 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 17/48 (35%), Gaps = 1/48 (2%) Query: 246 YILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILS 293 + EAS+ +++ E + II+L + +L Sbjct: 166 RGVSEASISPKVLEAF-EKEENILIGPSNPITSIGPIISLPGMRELLK 212 >5A0V-A nrPDB Length = 561 Score = 28.3 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 48/140 (34%), Gaps = 11/140 (7%) Query: 250 EASLQNQIVWKIKETVKEFYGENIKESPD-YERIINLRH-FKRILSLLEGQKIAFGGETD 307 E + N + K + ++I++ H + R ++ + + G Sbjct: 218 ERDISNVLRQVFANARKRIIVASFASHVHRIQQILDAAHEYGRRVAFVGRSMVRNMGIAR 277 Query: 308 EATRY-IAPTVLTDVDPKTKVMQEEIF-------G-PILPIVPVKNVDEAINFINEREKP 358 + + P ++ DV + E+ G P+ + + N D I +N Sbjct: 278 DLGYLKVPPGLVVDVKTLDDLPDSEVVLVCTGSQGEPMAALSRMANRDHQIRIVNGDTVI 337 Query: 359 LALYVFSHNHKLIKRMIDET 378 LA + N + R+I+ Sbjct: 338 LASSLIPGNENAVYRVINGL 357 >1WQS-A nrPDB Length = 173 Score = 28.3 bits (62), Expect = 7.9, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 12/33 (36%), Gaps = 1/33 (3%) Query: 308 EATRYIAPTVLTDVDPKTKVMQEEIFG-PILPI 339 +++PTV E FG PI I Sbjct: 15 GWGFWVSPTVFITTTHVIPTGVREFFGEPIESI 47 >5JN2-A nrPDB Length = 525 Score = 27.9 bits (61), Expect = 10.0, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 26/69 (37%) Query: 31 RRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLT 90 R + E K+++ D + + EV VL +DF E+ V + T Sbjct: 395 RAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKT 454 Query: 91 MLDEAYIQP 99 +L ++ Sbjct: 455 LLSRERLER 463 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.151 0.436 Lambda K H 0.267 0.0465 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,132,202 Number of Sequences: 36641 Number of extensions: 939691 Number of successful extensions: 3714 Number of sequences better than 10.0: 134 Number of HSP's better than 10.0 without gapping: 208 Number of HSP's successfully gapped in prelim test: 48 Number of HSP's that attempted gapping in prelim test: 2519 Number of HSP's gapped (non-prelim): 283 length of query: 485 length of database: 10,336,785 effective HSP length: 101 effective length of query: 384 effective length of database: 6,636,044 effective search space: 2548240896 effective search space used: 2548240896 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.3 bits)