BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P50750 (372 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3MIA-A nrPDB 721 0.0 5EFQ-A nrPDB 293 8e-80 4NST-A nrPDB 292 1e-79 3NIZ-A nrPDB 229 1e-60 6GU6-A nrPDB 227 8e-60 4AU8-A nrPDB 217 6e-57 5G6V-A nrPDB 217 7e-57 1V0B-A nrPDB 216 9e-57 2BPM-A nrPDB 216 1e-56 1UA2-A nrPDB 214 7e-56 4KRC-A nrPDB 212 3e-55 1G3N-A nrPDB 192 2e-49 4AGU-A nrPDB 190 1e-48 3GC0-A nrPDB 189 2e-48 4BBM-A nrPDB 189 2e-48 3ZDU-A nrPDB 187 8e-48 2W96-B nrPDB 186 1e-47 4BGQ-A nrPDB 180 1e-45 4IC8-A nrPDB 174 4e-44 4ZSG-A nrPDB 174 5e-44 2F9G-A nrPDB 163 1e-40 3OZ6-A nrPDB 163 1e-40 1CM8-A nrPDB 159 1e-39 6DTL-A nrPDB 159 2e-39 5Z33-A nrPDB 159 3e-39 4MYG-A nrPDB 157 6e-39 4CRL-A nrPDB 155 2e-38 4QTB-A nrPDB 155 2e-38 5NGU-A nrPDB 155 3e-38 3OHT-A nrPDB 155 3e-38 2I6L-A nrPDB 152 2e-37 4EWQ-A nrPDB 152 3e-37 3GC9-A nrPDB 150 9e-37 4O2Z-A nrPDB 149 1e-36 4QNY-A nrPDB 140 7e-34 3PG1-A nrPDB 132 3e-31 3N9X-A nrPDB 130 1e-30 3E7O-A nrPDB 129 2e-30 1JNK-A nrPDB 128 4e-30 3RP9-A nrPDB 125 2e-29 5ZTN-A nrPDB 125 3e-29 5AIR-A nrPDB 125 4e-29 5AWM-A nrPDB 124 8e-29 3FI2-A nrPDB 123 1e-28 4E7W-A nrPDB 122 3e-28 3E3P-A nrPDB 120 9e-28 2XS0-A nrPDB 119 3e-27 5Y86-A nrPDB 117 8e-27 3NIE-A nrPDB 114 7e-26 3NCG-A nrPDB 114 8e-26 3EB0-A nrPDB 113 1e-25 3DFA-A nrPDB 112 2e-25 6O6Q-A nrPDB 111 5e-25 3MA6-A nrPDB 110 8e-25 5JN2-A nrPDB 110 1e-24 3MN3-A nrPDB 107 7e-24 4RGJ-A nrPDB 106 2e-23 6HMD-A nrPDB 106 2e-23 2PVN-A nrPDB 105 2e-23 3DXN-A nrPDB 105 3e-23 3HZT-A nrPDB 105 3e-23 2UV2-A nrPDB 102 3e-22 4APC-A nrPDB 100 8e-22 5J5T-A nrPDB 100 1e-21 5ES1-A nrPDB 100 1e-21 5KZ7-A nrPDB 99 2e-21 6FD3-A nrPDB 99 3e-21 2QNJ-A nrPDB 99 3e-21 6C9D-A nrPDB 98 5e-21 4FIE-A nrPDB 98 5e-21 2Q0N-A nrPDB 98 6e-21 4MD7-E nrPDB 98 7e-21 3COM-A nrPDB 98 7e-21 4JDH-A nrPDB 97 8e-21 2HAK-A nrPDB 97 8e-21 6EII-A nrPDB 97 9e-21 3Q53-A nrPDB 97 9e-21 4XBR-A nrPDB 97 1e-20 3LIJ-A nrPDB 97 1e-20 3RAW-A nrPDB 96 2e-20 1U5R-A nrPDB 96 2e-20 3F3Z-A nrPDB 96 3e-20 2GCD-A nrPDB 96 3e-20 3TAC-A nrPDB 95 5e-20 4REW-A nrPDB 95 5e-20 4IAN-A nrPDB 95 6e-20 5XVU-A nrPDB 94 8e-20 4CFH-A nrPDB 94 1e-19 2A1A-B nrPDB 94 1e-19 5YKS-A nrPDB 93 2e-19 4LFI-A nrPDB 92 3e-19 4MVF-A nrPDB 92 3e-19 3H4J-B nrPDB 92 4e-19 4B6L-A nrPDB 92 4e-19 4RED-A nrPDB 92 5e-19 3UIU-A nrPDB 92 5e-19 4YZB-A nrPDB 91 6e-19 6QAU-A nrPDB 91 7e-19 6E2O-A nrPDB 91 7e-19 4UZD-A nrPDB 91 7e-19 6CQF-A nrPDB 91 8e-19 4LG4-A nrPDB 91 9e-19 6AO5-A nrPDB 91 1e-18 6HXF-B nrPDB 91 1e-18 3D2K-A nrPDB 89 2e-18 1ZXE-A nrPDB 89 2e-18 4JXF-A nrPDB 89 2e-18 2F57-A nrPDB 89 3e-18 2WO6-A nrPDB 89 4e-18 2BRG-A nrPDB 88 5e-18 2VN9-A nrPDB 88 5e-18 3Q5I-A nrPDB 88 6e-18 4D28-A nrPDB 88 6e-18 6FYV-A nrPDB 87 1e-17 4CZT-A nrPDB 87 1e-17 4B8L-A nrPDB 87 1e-17 5D7A-A nrPDB 87 1e-17 4WNO-A nrPDB 87 1e-17 5WAX-A nrPDB 87 1e-17 4KS7-A nrPDB 87 2e-17 2WQN-A nrPDB 86 2e-17 3GUB-A nrPDB 86 2e-17 2Y7J-A nrPDB 86 2e-17 5EZV-A nrPDB 86 2e-17 4CQG-A nrPDB 86 2e-17 4CFF-A nrPDB 86 2e-17 3IS5-A nrPDB 86 2e-17 2XNP-A nrPDB 86 3e-17 5UNP-A nrPDB 85 4e-17 2YCR-A nrPDB 85 5e-17 5XZW-A nrPDB 85 6e-17 5X8I-B nrPDB 84 1e-16 2VZ6-A nrPDB 84 1e-16 2YZA-A nrPDB 84 1e-16 3I6U-A nrPDB 84 1e-16 2V7O-A nrPDB 84 1e-16 4U41-A nrPDB 83 2e-16 5U6Y-A nrPDB 83 2e-16 4PDS-A nrPDB 83 2e-16 3BHH-A nrPDB 82 4e-16 3UDB-A nrPDB 82 4e-16 5F9E-A nrPDB 82 4e-16 2J90-A nrPDB 82 5e-16 4I6B-A nrPDB 81 6e-16 2Z7Q-A nrPDB 81 7e-16 4YNZ-A nrPDB 81 9e-16 2WTK-C nrPDB 80 1e-15 4D2V-A nrPDB 80 1e-15 5DYK-A nrPDB 80 2e-15 3ZUT-A nrPDB 79 3e-15 5HVK-A nrPDB 79 3e-15 3SOA-A nrPDB 79 3e-15 3EQC-A nrPDB 79 3e-15 4C0T-A nrPDB 79 3e-15 6FDY-U nrPDB 79 4e-15 5X02-A nrPDB 78 5e-15 4FZF-B nrPDB 78 5e-15 4QMW-A nrPDB 78 5e-15 4AF3-A nrPDB 78 5e-15 6CMJ-A nrPDB 78 6e-15 4E93-A nrPDB 78 7e-15 3MDY-A nrPDB 78 7e-15 4XUF-A nrPDB 77 9e-15 4EQM-A nrPDB 77 1e-14 2W1I-A nrPDB 77 1e-14 2JAM-A nrPDB 77 1e-14 2H8H-A nrPDB 77 1e-14 5KKR-C nrPDB 77 1e-14 2BDW-A nrPDB 77 1e-14 3UC3-A nrPDB 77 1e-14 6CTH-A nrPDB 77 2e-14 3KK8-A nrPDB 77 2e-14 4CSV-A nrPDB 77 2e-14 3IO7-A nrPDB 76 2e-14 3LM0-A nrPDB 76 2e-14 3A4O-X nrPDB 76 3e-14 4TPT-A nrPDB 76 3e-14 6F3F-A nrPDB 76 3e-14 2JDO-A nrPDB 75 3e-14 5VO2-A nrPDB 75 3e-14 5UIU-A nrPDB 75 3e-14 5DBX-A nrPDB 75 4e-14 5SYS-A nrPDB 75 4e-14 1K9A-A nrPDB 75 4e-14 5FET-A nrPDB 75 4e-14 5D9K-A nrPDB 75 4e-14 4JLC-A nrPDB 75 4e-14 5LOH-A nrPDB 75 4e-14 6DBM-A nrPDB 75 5e-14 1PHK-A nrPDB 75 6e-14 1BYG-A nrPDB 75 6e-14 4M7I-A nrPDB 74 7e-14 1PY5-A nrPDB 74 8e-14 4L42-A nrPDB 74 9e-14 4E20-A nrPDB 74 9e-14 5YV8-A nrPDB 74 9e-14 6NT9-A nrPDB 74 1e-13 3DAK-A nrPDB 73 2e-13 6DBN-A nrPDB 73 2e-13 4J52-A nrPDB 73 2e-13 4XCU-A nrPDB 73 2e-13 2PMN-X nrPDB 73 2e-13 4RLP-A nrPDB 73 2e-13 6O8B-A nrPDB 73 2e-13 2OU7-A nrPDB 73 2e-13 4C59-A nrPDB 73 2e-13 4OLI-A nrPDB 73 2e-13 2XIK-A nrPDB 73 2e-13 4EUT-A nrPDB 73 2e-13 3QA8-A nrPDB 72 3e-13 4EUU-A nrPDB 72 3e-13 5FG8-A nrPDB 72 3e-13 2JC6-A nrPDB 72 4e-13 5JZN-A nrPDB 72 4e-13 4XI2-A nrPDB 72 4e-13 5MJB-A nrPDB 72 5e-13 5IG1-A nrPDB 71 6e-13 6E4F-A nrPDB 71 6e-13 6CCF-A nrPDB 71 1e-12 4HVI-A nrPDB 70 1e-12 2W4O-A nrPDB 70 1e-12 3FXW-A nrPDB 70 1e-12 2HK5-A nrPDB 70 1e-12 3MV5-A nrPDB 70 2e-12 3Q4U-A nrPDB 70 2e-12 5KCV-A nrPDB 70 2e-12 3ORZ-A nrPDB 70 2e-12 2PSQ-A nrPDB 69 2e-12 4AN9-A nrPDB 69 2e-12 4XEY-B nrPDB 69 3e-12 4FG9-A nrPDB 69 3e-12 3ORP-A nrPDB 69 3e-12 4TNB-A nrPDB 69 3e-12 4GS6-A nrPDB 69 3e-12 3CJF-A nrPDB 69 4e-12 2VWV-A nrPDB 69 4e-12 5LPZ-A nrPDB 69 4e-12 6NPU-A nrPDB 69 4e-12 5LPV-A nrPDB 69 4e-12 4G3E-A nrPDB 68 5e-12 3QGY-A nrPDB 68 5e-12 1U59-A nrPDB 68 5e-12 5L6P-A nrPDB 68 5e-12 2R2P-A nrPDB 68 6e-12 3DKO-A nrPDB 68 6e-12 6HV0-A nrPDB 68 6e-12 5EG3-A nrPDB 68 7e-12 3DLS-A nrPDB 68 7e-12 2PL0-A nrPDB 68 7e-12 2FO0-A nrPDB 68 7e-12 5VD3-A nrPDB 68 8e-12 3TXO-A nrPDB 68 8e-12 4K33-A nrPDB 67 1e-11 5A46-A nrPDB 67 1e-11 4Y93-A nrPDB 67 1e-11 3GQL-A nrPDB 67 1e-11 1KOA-A nrPDB 67 1e-11 4KIK-B nrPDB 67 1e-11 5TE0-A nrPDB 67 1e-11 3UTO-A nrPDB 67 1e-11 2OZO-A nrPDB 67 1e-11 5TQX-A nrPDB 67 1e-11 4IDT-A nrPDB 67 2e-11 1JPA-A nrPDB 67 2e-11 4P5Q-A nrPDB 67 2e-11 1ZWS-A nrPDB 67 2e-11 1S9I-A nrPDB 67 2e-11 5AP3-A nrPDB 66 2e-11 5N23-A nrPDB 66 2e-11 2A27-A nrPDB 66 2e-11 2DQ7-X nrPDB 66 2e-11 3KN6-A nrPDB 66 2e-11 2X4F-A nrPDB 66 2e-11 2Y6O-A nrPDB 66 3e-11 2XYN-A nrPDB 66 3e-11 3TT0-A nrPDB 66 3e-11 6GVJ-A nrPDB 66 3e-11 3PPZ-A nrPDB 66 3e-11 5B2L-A nrPDB 65 3e-11 5H2U-A nrPDB 65 3e-11 5HI2-A nrPDB 65 3e-11 3HKO-A nrPDB 65 4e-11 5X5O-A nrPDB 65 4e-11 1AD5-A nrPDB 65 4e-11 4OW8-A nrPDB 65 5e-11 4AT3-A nrPDB 65 5e-11 4X3F-A nrPDB 65 5e-11 6J5U-C nrPDB 65 6e-11 4WB7-A nrPDB 65 6e-11 2YAB-A nrPDB 65 6e-11 2HW6-A nrPDB 65 6e-11 3HMP-A nrPDB 65 6e-11 1VZO-A nrPDB 65 6e-11 6B2Q-A nrPDB 65 7e-11 3BEA-A nrPDB 64 7e-11 2QLU-A nrPDB 64 7e-11 1NY3-A nrPDB 64 7e-11 2OZA-A nrPDB 64 8e-11 4PL5-B nrPDB 64 8e-11 4RA4-A nrPDB 64 8e-11 3KA0-A nrPDB 64 9e-11 2OGV-A nrPDB 64 9e-11 5UUU-A nrPDB 64 1e-10 5X3F-B nrPDB 64 1e-10 3KUL-B nrPDB 64 1e-10 5O0Y-A nrPDB 64 1e-10 3PVW-A nrPDB 64 1e-10 4M66-A nrPDB 64 2e-10 4UYA-A nrPDB 63 2e-10 1FVR-A nrPDB 63 2e-10 5HIE-A nrPDB 63 2e-10 3A8W-A nrPDB 63 2e-10 4PDO-A nrPDB 63 2e-10 3SOC-A nrPDB 63 2e-10 5KMM-A nrPDB 63 2e-10 2JD5-A nrPDB 63 2e-10 5U6C-A nrPDB 63 2e-10 4R7H-A nrPDB 63 3e-10 4PWN-A nrPDB 62 3e-10 2QKW-B nrPDB 62 3e-10 3KRL-A nrPDB 62 3e-10 1LUF-A nrPDB 62 3e-10 2ZMD-A nrPDB 62 4e-10 3HDN-A nrPDB 62 4e-10 5C26-A nrPDB 62 5e-10 3DB8-A nrPDB 62 6e-10 4FR4-A nrPDB 62 6e-10 4YHJ-A nrPDB 61 6e-10 4FL3-A nrPDB 61 6e-10 2Y4I-B nrPDB 61 6e-10 5AMN-A nrPDB 61 8e-10 3OMV-A nrPDB 61 9e-10 1FOT-A nrPDB 60 1e-09 6E9W-A nrPDB 60 1e-09 3V5Q-A nrPDB 60 1e-09 3NYO-A nrPDB 60 1e-09 3C51-A nrPDB 60 1e-09 3ALO-A nrPDB 60 2e-09 5IKW-A nrPDB 60 2e-09 6BDL-A nrPDB 60 2e-09 3C1X-A nrPDB 60 2e-09 6CKI-A nrPDB 59 2e-09 6GQK-A nrPDB 59 3e-09 3MY0-A nrPDB 59 3e-09 5HLW-A nrPDB 59 3e-09 6ED6-A nrPDB 59 3e-09 2WTK-B nrPDB 59 3e-09 5O2C-A nrPDB 59 4e-09 5O2B-A nrPDB 58 5e-09 5XD6-A nrPDB 58 5e-09 6BXI-A nrPDB 58 7e-09 5GNK-A nrPDB 58 7e-09 3LZB-A nrPDB 58 8e-09 6FER-A nrPDB 58 8e-09 4NEU-A nrPDB 58 8e-09 4WUA-A nrPDB 57 9e-09 4NIF-A nrPDB 57 1e-08 3UIM-A nrPDB 57 1e-08 4HZS-A nrPDB 57 1e-08 1U54-B nrPDB 57 1e-08 5GRN-A nrPDB 57 2e-08 3SV0-A nrPDB 56 2e-08 4JG6-A nrPDB 56 2e-08 3TKU-A nrPDB 56 2e-08 4UY9-A nrPDB 56 2e-08 4OTD-A nrPDB 56 2e-08 5FM2-A nrPDB 56 2e-08 5TOS-A nrPDB 56 3e-08 5U6B-A nrPDB 56 3e-08 3DTC-A nrPDB 56 3e-08 4AW2-A nrPDB 55 4e-08 4XLV-A nrPDB 55 4e-08 3BBT-B nrPDB 55 4e-08 4CRS-A nrPDB 55 4e-08 3PLS-A nrPDB 55 5e-08 5FQD-C nrPDB 55 5e-08 2BUJ-A nrPDB 55 6e-08 2RIO-A nrPDB 55 6e-08 1KOB-A nrPDB 54 8e-08 3QUP-A nrPDB 54 1e-07 3PP0-A nrPDB 54 1e-07 4TN6-A nrPDB 54 1e-07 5WNL-A nrPDB 54 1e-07 6BFN-A nrPDB 54 1e-07 3VN9-A nrPDB 54 2e-07 3LLT-A nrPDB 53 2e-07 2VD5-A nrPDB 53 2e-07 2X7G-A nrPDB 53 2e-07 4EBW-A nrPDB 53 2e-07 2J0K-A nrPDB 53 2e-07 4LRM-A nrPDB 53 2e-07 3SXS-A nrPDB 53 2e-07 3HNG-A nrPDB 52 3e-07 4RT7-A nrPDB 52 3e-07 3I81-A nrPDB 52 3e-07 4BTK-A nrPDB 52 3e-07 3QD2-B nrPDB 52 3e-07 3FME-A nrPDB 52 4e-07 4F9B-A nrPDB 52 4e-07 4YFF-A nrPDB 52 5e-07 4NFN-A nrPDB 52 5e-07 2H34-A nrPDB 52 5e-07 3AOX-A nrPDB 52 6e-07 6FEX-A nrPDB 51 9e-07 3G0E-A nrPDB 51 9e-07 3G2F-A nrPDB 50 1e-06 2I0E-A nrPDB 50 2e-06 3VHK-A nrPDB 50 2e-06 3PFQ-A nrPDB 49 2e-06 3ZZW-A nrPDB 49 3e-06 6BSD-A nrPDB 49 3e-06 1TKI-A nrPDB 49 3e-06 4JRN-A nrPDB 49 3e-06 5E8V-A nrPDB 49 3e-06 4Y83-A nrPDB 49 4e-06 5VC6-A nrPDB 49 4e-06 4X7Q-B nrPDB 49 4e-06 4LQP-A nrPDB 48 6e-06 3M42-A nrPDB 48 8e-06 4NT4-A nrPDB 47 1e-05 5X1R-A nrPDB 47 1e-05 3ZBF-A nrPDB 47 2e-05 2C47-A nrPDB 46 2e-05 4H1J-A nrPDB 46 2e-05 5WNO-A nrPDB 46 2e-05 5TUR-A nrPDB 46 2e-05 4RC3-A nrPDB 46 2e-05 3BGP-A nrPDB 46 3e-05 5AR8-A nrPDB 46 3e-05 3LMG-A nrPDB 45 3e-05 2CMW-A nrPDB 45 6e-05 4F0G-A nrPDB 44 9e-05 5X18-A nrPDB 44 1e-04 4MWI-A nrPDB 44 1e-04 1CSN-A nrPDB 44 2e-04 4XHH-A nrPDB 43 2e-04 4M69-B nrPDB 43 2e-04 2CHL-A nrPDB 43 2e-04 4BTF-A nrPDB 43 3e-04 5M07-A nrPDB 42 4e-04 5L2Q-C nrPDB 42 4e-04 4IX6-A nrPDB 42 4e-04 4XHL-A nrPDB 42 5e-04 5UU1-A nrPDB 40 0.001 5VDK-A nrPDB 40 0.002 4L68-A nrPDB 39 0.005 5J0A-A nrPDB 38 0.009 5USZ-A nrPDB 37 0.016 6J6I-B nrPDB 36 0.021 2RSV-A nrPDB 36 0.024 2PZI-A nrPDB 36 0.024 4Y12-A nrPDB 36 0.027 4BWP-A nrPDB 36 0.030 2LAV-A nrPDB 35 0.038 4WOV-A nrPDB 34 0.11 4WWA-A nrPDB 34 0.12 5C01-A nrPDB 34 0.13 3JS9-A nrPDB 32 0.36 2BEF-A nrPDB 32 0.49 5CLR-A nrPDB 32 0.64 3ENH-A nrPDB 31 0.94 6G38-A nrPDB 31 1.1 4O1O-A nrPDB 30 2.2 3RFI-A nrPDB 28 8.4 >3MIA-A nrPDB Length = 351 Score = 721 bits (1860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 345/345 (100%), Positives = 345/345 (100%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP Sbjct: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK Sbjct: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP Sbjct: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 Query: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK Sbjct: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 >5EFQ-A nrPDB Length = 347 Score = 293 bits (750), Expect = 8e-80, Method: Compositional matrix adjust. Identities = 151/312 (48%), Positives = 214/312 (68%), Gaps = 10/312 (3%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V K++ + IG+GT+G+V+KAR + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 ++++N+ EI K A + + KG+ YLVF++ +HDL GLL + LV F + IK M+ L Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 129 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + GL Y H+ LHRD+K +N+L+ G +KLADFGLAR +S ++ S+P YTN+V+TLW Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYS-SEESRP--YTNKVITLW 186 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS++CGS P VW Sbjct: 187 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 246 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP-YALDLIDKLLVLDPAQRIDSDDALNH 312 P+V + ++ K +RK+++ +V P ALDL D +L LDP++R ++ AL Sbjct: 247 PDVIKLPYFNTMKPKKQYRRKLREE---FVFIPAAALDLFDYMLALDPSKRCTAEQALQC 303 Query: 313 DFFWSDPMPSDL 324 +F D PS + Sbjct: 304 EFL-RDVEPSKM 314 >4NST-A nrPDB Length = 351 Score = 292 bits (748), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 156/340 (45%), Positives = 219/340 (64%), Gaps = 18/340 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V K++ + IG+GT+G+V+KA+ + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 76 ENVVNLIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 +VVN+ EI K A + + KG+ YLVF++ +HDL GLL + LV F+ IK M+ L Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTL 192 + GL Y H+ LHRD+K +N+L+ G +KLADFGLAR + NS+ +R YTN+V+TL Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLY----NSEESRPYTNKVITL 187 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 WYRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS+LCGS P V Sbjct: 188 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAV 247 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 WP+V + ++ K +R++++ +++ ALDL+D +L LDP++R ++ L Sbjct: 248 WPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSA-ALDLLDHMLTLDPSKRCTAEQTLQS 305 Query: 313 DFF----WSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQ 348 DF S P DL H E + RR+ Q Sbjct: 306 DFLKDVELSKMAPPDL-----PHWQDCHELWSKKRRRQRQ 340 >3NIZ-A nrPDB Length = 311 Score = 229 bits (585), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 121/300 (40%), Positives = 183/300 (61%), Gaps = 15/300 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KY+KL K+G+GT+G V+KA+ + G+ VALK++ ++ E EG P TA+REI +L+ L H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+V+LI++ ++ RC + LVF+F E DL +L S+IK + LL Sbjct: 79 PNIVSLIDVIHSE-----RC---LTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLR 130 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ + H+++ILHRD+K N+LI DG LKLADFGLARAF + S YT+ VVTLWYR Sbjct: 131 GVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRS----YTHEVVTLWYR 186 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 P++L+G + Y +D+W GCI AEM T P+ G T+ QL I + G+ P WP Sbjct: 187 APDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQ 246 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 V L+++ +K+ + + ++ +DL+ +L DP +RI + DA+NH +F Sbjct: 247 VQELPLWKQRTFQVFEKKPWSSIIPGFCQE--GIDLLSNMLCFDPNKRISARDAMNHPYF 304 >6GU6-A nrPDB Length = 302 Score = 227 bits (578), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 124/300 (41%), Positives = 182/300 (60%), Gaps = 19/300 (6%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H N+ Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 68 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL--SEIKRVMQMLLNG 136 V+L ++ + +YL+F+F DL L ++ + S +K + +L G Sbjct: 69 VSLQDVLMQDS--------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 120 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYR 195 + + H ++LHRD+K N+LI G +KLADFGLARAF + P R YT+ VVTLWYR Sbjct: 121 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-----PIRVYTHEVVTLWYR 175 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVWP Sbjct: 176 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 235 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 V++ + Y K K + + +K D LDL+ K+L+ DPA+RI ALNH +F Sbjct: 236 VESLQDY-KNTFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >4AU8-A nrPDB Length = 296 Score = 217 bits (553), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 128/308 (41%), Positives = 179/308 (58%), Gaps = 23/308 (7%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 KYEKL KIG+GT+G VFKA++R+T + VALK+V ++++ EG P +ALREI +L+ LKH+N Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 66 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 +V L ++ + + LVF+FC+ DL + +K + LL GL Sbjct: 67 IVRLHDVLHSDK--------KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYRP 196 + H +LHRD+K N+LI R+G LKLADFGLARAF + P R Y+ VVTLWYRP Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGI-----PVRCYSAEVVTLWYRP 173 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEVWPN 255 P++L G + Y ID+W AGCI AE+ P+ GN QL I +L G+ T E WP+ Sbjct: 174 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPS 233 Query: 256 VDNYELYEKLELVKGQKR--KVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + Y+ + V +L A R DL+ LL +P QRI +++AL H Sbjct: 234 MTKLPDYKPYPMYPATTSLVNVVPKLNATGR-----DLLQNLLKCNPVQRISAEEALQHP 288 Query: 314 FFWSDPMP 321 +F SD P Sbjct: 289 YF-SDFCP 295 >5G6V-A nrPDB Length = 324 Score = 217 bits (552), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 123/299 (41%), Positives = 173/299 (57%), Gaps = 15/299 (5%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y KL K+G+GT+ V+K + + T VALK++ +E+E EG P TA+RE+ +L+ LKH N+ Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI 62 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 V L +I T+ S + LVF++ + DL L + + +K + LL GL Sbjct: 63 VTLHDIIHTEKS--------LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y HR K+LHRD+K N+LI G LKLADFGLARA S+ + Y N VVTLWYRPP+ Sbjct: 115 YCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKT----YDNEVVTLWYRPPD 170 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 +LLG DY ID+WG GCI EM T P+ G+T + QL I ++ G+ T E WP + + Sbjct: 171 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 230 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 E ++ K + + A D DL+ KLL + RI ++DA+ H FF S Sbjct: 231 NEEFKTYNYPKYRAEALLSH--APRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLS 287 >1V0B-A nrPDB Length = 288 Score = 216 bits (551), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 125/310 (40%), Positives = 173/310 (55%), Gaps = 36/310 (11%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KY L KIG+GT+G V+KA++ G+ ALKK+ +E E EG P T +REI IL+ LKH Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNN-YGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+V L ++ TK + LVF+ + DL LL K + LLN Sbjct: 60 SNIVKLYDVIHTKKR--------LVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLN 111 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ Y H ++LHRD+K N+LI R+G LK+ADFGLARAF + +YT+ VVTLWYR Sbjct: 112 GIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIP----VRKYTHEVVTLWYR 167 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 P++L+G + Y ID+W GCI AEM +P+ G +E QL I ++ G+ + WPN Sbjct: 168 APDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPN 227 Query: 256 VD-------NYELYEKL---ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 V N+ +YE L +KG D +DL+ K+L LDP QRI Sbjct: 228 VTELPKYDPNFTVYEPLPWESFLKG-------------LDESGIDLLSKMLKLDPNQRIT 274 Query: 306 SDDALNHDFF 315 + AL H +F Sbjct: 275 AKQALEHAYF 284 >2BPM-A nrPDB Length = 309 Score = 216 bits (550), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 124/314 (39%), Positives = 182/314 (57%), Gaps = 19/314 (6%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P D + ++K+ KIG+GT+G V+KAR++ TG+ VALKK+ ++ E EG P TA+REI +L Sbjct: 2 PLVD-MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLL 60 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRV 129 + L H N+V L+++ T + +YLVF+F DL + ++ L L IK Sbjct: 61 KELNHPNIVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSY 112 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + LL GL + H +++LHRD+K N+LI +G +KLADFGLARAF + + YT+ V Sbjct: 113 LFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRT----YTHEV 168 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 VTLWYR PE+LLG + Y +D+W GCI AEM TR + G++E QL I + G+ Sbjct: 169 VTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPD 228 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 VWP V + Y K K ++ + D L+ ++L DP +RI + A Sbjct: 229 EVVWPGVTSMPDY-KPSFPKWARQDFSKVVPPLDED--GRSLLSQMLHYDPNKRISAKAA 285 Query: 310 LNHDFFW--SDPMP 321 L H FF + P+P Sbjct: 286 LAHPFFQDVTKPVP 299 >1UA2-A nrPDB Length = 346 Score = 214 bits (544), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 127/309 (41%), Positives = 179/309 (57%), Gaps = 21/309 (6%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM---ENEKEGFPITALREIKILQLLK 74 +YEKL +G+G F V+KAR + T Q VA+KK+ + K+G TALREIK+LQ L Sbjct: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H N++ L++ K++ I LVFDF E DL ++ + + T S IK M M L Sbjct: 71 HPNIIGLLDAFGHKSN--------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLW 193 GL Y+H++ ILHRD+K N+L+ +GVLKLADFGLA++F PNR YT++VVT W Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-----GSPNRAYTHQVVTRW 177 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PELL G R YG +D+W GCI+AE+ R P + G+++ QL I + G+ T E W Sbjct: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 P++ + Y + G + A D LDLI L + +P RI + AL Sbjct: 238 PDMCSLPDYVTFKSFPGI--PLHHIFSAAGDD--LLDLIQGLFLFNPCARITATQALKMK 293 Query: 314 FFWSDPMPS 322 +F + P P+ Sbjct: 294 YFSNRPGPT 302 >4KRC-A nrPDB Length = 317 Score = 212 bits (539), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 117/307 (38%), Positives = 182/307 (59%), Gaps = 22/307 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S++++L K+G GT+ V+K ++ TG VALK+V +++E EG P TA+REI +++ LKHE Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT-----LSEIKRVMQ 131 N+V L ++ T+ + LVF+F ++DL + + V T L+ +K Sbjct: 64 NIVRLYDVIHTE--------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 LL GL + H NKILHRD+K N+LI + G LKL DFGLARAF + N+ +++ VVT Sbjct: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNT----FSSEVVT 171 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 LWYR P++L+G R Y ID+W GCI+AEM T P+ G ++ QL LI + G+ Sbjct: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY---ALDLIDKLLVLDPAQRIDSDD 308 +WP+V Y + + R ++ L+ + ++P +D + LL L+P R+ + Sbjct: 232 LWPSVTKLPKYNP-NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Query: 309 ALNHDFF 315 AL+H +F Sbjct: 291 ALHHPWF 297 >1G3N-A nrPDB Length = 326 Score = 192 bits (487), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 119/311 (38%), Positives = 179/311 (57%), Gaps = 23/311 (7%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQK-VALKKVLMENEKEGFPITALREIKIL 70 C +YE +A+IG+G +G+VFKAR K G + VALK+V ++ +EG P++ +RE+ +L Sbjct: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 Query: 71 QLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE-I 126 + L+ H NVV L ++C S +R + + LVF+ + DL L V +E I Sbjct: 66 RHLETFEHPNVVRLFDVC--TVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 K +M LL GL ++H ++++HRD+K N+L+T G +KLADFGLAR +S T Sbjct: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA-----LT 177 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + VVTLWYR PE+LL + Y P+DLW GCI AEM+ R P+ +G+++ QL I + G Sbjct: 178 SVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL--DLIDKLLVLDPAQRI 304 E WP + L + K ++ +V D L DL+ K L +PA+RI Sbjct: 237 LPGEEDWPR--DVALPR-----QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI 289 Query: 305 DSDDALNHDFF 315 + AL+H +F Sbjct: 290 SAYSALSHPYF 300 >4AGU-A nrPDB Length = 311 Score = 190 bits (482), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 103/300 (34%), Positives = 165/300 (55%), Gaps = 13/300 (4%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KYEK+ KIG+G++G VFK R+R TGQ VA+KK L + ALREI++L+ LKH Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+VNL+E+ R K ++LVF++C+H + L +K + L Sbjct: 62 PNLVNLLEVFRRKR--------RLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQ 113 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 + + H++ +HRD+K N+LIT+ V+KL DFG AR + + Y + V T WYR Sbjct: 114 AVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLT----GPSDYYDDEVATRWYR 169 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PELL+G+ YGPP+D+W GC+ AE+ + P+ G ++ QL LI + G + P Sbjct: 170 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV 229 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + + +++ + + + + P AL L+ L +DP +R+ + L+H +F Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNISYP-ALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >3GC0-A nrPDB Length = 329 Score = 189 bits (480), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 108/311 (34%), Positives = 179/311 (57%), Gaps = 20/311 (6%) Query: 10 CPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI 69 P + +Y ++ K+G+GT+GEV+KA T + VA+K++ +E+E+EG P TA+RE+ + Sbjct: 27 APSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSL 86 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 L+ L+H N++ L + +N ++L+F++ E+DL + ++ IK Sbjct: 87 LKELQHRNIIELKSVIH-----HNH---RLHLIFEYAENDLKKYMDKN-PDVSMRVIKSF 137 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLIT-----RDGVLKLADFGLARAFSLAKNSQPNR 184 + L+NG+ + H + LHRD+K N+L++ VLK+ DFGLARAF + + Sbjct: 138 LYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIR----Q 193 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 +T+ ++TLWYRPPE+LLG R Y +D+W CI AEM ++P+ G++E QL I ++ Sbjct: 194 FTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEV 253 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 G WP V + K K + + +K L A + D LDL+ +L +DP +RI Sbjct: 254 LGLPDDTTWPGVTALPDW-KQSFPKFRGKTLKRVLGALLDD-EGLDLLTAMLEMDPVKRI 311 Query: 305 DSDDALNHDFF 315 + +AL H +F Sbjct: 312 SAKNALEHPYF 322 >4BBM-A nrPDB Length = 331 Score = 189 bits (479), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 106/308 (34%), Positives = 173/308 (56%), Gaps = 23/308 (7%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KYE L +G+G++G V K R++ TG+ VA+KK L ++ + A+REIK+L+ L+H Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 EN+VNL+E+C+ K YLVF+F +H + L +++ + ++N Sbjct: 84 ENLVNLLEVCKKKK--------RWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIIN 135 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ + H + I+HRD+K N+L+++ GV+KL DFG AR + + Y + V T WYR Sbjct: 136 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLA----APGEVYDDEVATRWYR 191 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PELL+G+ YG +D+W GC++ EM+ P+ G+++ QL I G++ P Sbjct: 192 APELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPR---- 247 Query: 256 VDNYELYEKLELVKGQKR-KVKDRLKAYVRDP----YALDLIDKLLVLDPAQRIDSDDAL 310 + EL+ K + G + ++K+R R P +DL K L +DP +R + L Sbjct: 248 --HQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELL 305 Query: 311 NHDFFWSD 318 +HDFF D Sbjct: 306 HHDFFQMD 313 >3ZDU-A nrPDB Length = 325 Score = 187 bits (474), Expect = 8e-48, Method: Compositional matrix adjust. Identities = 102/300 (34%), Positives = 165/300 (55%), Gaps = 14/300 (4%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 YE L K+G+G++G V K +H+ TGQ VA+K + E ++ A+REIK L+ HEN+ Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHHENL 63 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 VNLIE+ R K I+LVF+F +H + L + +++ + +L + Sbjct: 64 VNLIEVFRQKKK--------IHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAID 115 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y+H N I+HRD+K N+L+++ G+ KL DFG AR + + + Y + V T WYR PE Sbjct: 116 YLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLA----APGDIYDDEVATRWYRAPE 171 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 L+L + YG P+D+W GC++ EM T +P + +++ L I G+++P + Sbjct: 172 LVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSK 231 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSD 318 ++ + L + Q K R K + D++ L +DPA RI S D L+H++F D Sbjct: 232 SPIFAGVVLPQVQHPK-NARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 >2W96-B nrPDB Length = 306 Score = 186 bits (473), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 116/311 (37%), Positives = 170/311 (54%), Gaps = 28/311 (9%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL--- 73 S+YE +A+IG G +G V+KAR +G VALK V + N +EG PI+ +RE+ +L+ L Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE-IKRVMQM 132 +H NVV L+++C T + +R + + LVF+ + DL L +E IK +M+ Sbjct: 64 EHPNVVRLMDVCATSRT--DR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 120 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L GL ++H N I+HRD+K N+L+T G +KLADFGLAR +S P VVTL Sbjct: 121 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPV-----VVTL 175 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 WYR PE+LL + Y P+D+W GCI AEM+ R P+ GN+E QL I L G + Sbjct: 176 WYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 234 Query: 253 WPNVDNYELYEKLELVKGQ-----KRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 WP + L +G R V+ + + L+ ++L +P +RI + Sbjct: 235 WPR--------DVSLPRGAFPPRGPRPVQSVVPEM--EESGAQLLLEMLTFNPHKRISAF 284 Query: 308 DALNHDFFWSD 318 AL H + D Sbjct: 285 RALQHSYLHKD 295 >4BGQ-A nrPDB Length = 304 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 106/300 (35%), Positives = 159/300 (53%), Gaps = 12/300 (4%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++K+E L +G+G +G V K RH++T + VA+KK E E T LRE+K+L+ LK Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 EN+V L E R + G +YLVF++ E ++ LL + ++K + L+ Sbjct: 71 ENIVELKEAFRRR--------GKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIK 122 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 +++ H+N I+HRD+K N+LI+ + VLKL DFG AR S N+ Y V T WYR Sbjct: 123 AIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNAN---YDEEVATRWYR 179 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PELLLG YG +D+W GCI+ E+ P+ G +E QL I ++ G + E Sbjct: 180 SPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKL 238 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + + L + +R + + LDL+ LL LDPA R ++ LNH F Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 >4IC8-A nrPDB Length = 442 Score = 174 bits (442), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 108/313 (34%), Positives = 162/313 (51%), Gaps = 16/313 (5%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-----LMENEKEGFPITALREIK 68 D +YE + IG G +G V AR R TGQ+VA+KK+ ++ N K LRE+K Sbjct: 52 DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKR-----TLRELK 106 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR 128 IL+ KH+N++ + +I R PY K S+Y+V D E DL ++ + TL ++ Sbjct: 107 ILKHFKHDNIIAIKDILRPTV-PYGEFK-SVYVVLDLMESDLHQIIHSSQ-PLTLEHVRY 163 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + LL GL Y+H +++HRD+K +N+L+ + LK+ DFG+AR + T Sbjct: 164 FLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEY 223 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 V T WYR PEL+L +Y IDLW GCI EM R + G HQL LI + G+ Sbjct: 224 VATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTP 283 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 +P V V + ++ + ++ V D AL L+ ++L +P+ RI + Sbjct: 284 SPAVIQAVGAERVRAYIQSLP-PRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAA 342 Query: 309 ALNHDFF--WSDP 319 AL H F + DP Sbjct: 343 ALRHPFLAKYHDP 355 >4ZSG-A nrPDB Length = 347 Score = 174 bits (442), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 110/330 (33%), Positives = 163/330 (49%), Gaps = 50/330 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-----LMENEKEGFPITALREIK 68 D +YE + IG G +G V AR R TGQ+VA+KK+ ++ N K LRE+K Sbjct: 4 DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKR-----TLRELK 58 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR 128 IL+ KH+N++ + +I R PY K S+Y+V D E DL ++ + TL ++ Sbjct: 59 ILKHFKHDNIIAIKDILRPTV-PYGEFK-SVYVVLDLMESDLHQIIHSSQ-PLTLEHVRY 115 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + LL GL Y+H +++HRD+K +N+L+ + LK+ DFG+AR + T Sbjct: 116 FLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEY 175 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 V T WYR PEL+L +Y IDLW GCI EM R + G HQL LI + G+ Sbjct: 176 VATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTP 235 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR-----------------DPYALDL 291 +P V V +R++AY++ D AL L Sbjct: 236 SPAVIQAVG------------------AERVRAYIQSLPPRQPVPWETVYPGADRQALSL 277 Query: 292 IDKLLVLDPAQRIDSDDALNHDFF--WSDP 319 + ++L +P+ RI + AL H F + DP Sbjct: 278 LGRMLRFEPSARISAAAALRHPFLAKYHDP 307 >2F9G-A nrPDB Length = 353 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 106/316 (33%), Positives = 172/316 (54%), Gaps = 18/316 (5%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S ++ + +G+G +G V A H+ TG+ VA+KK+ +K F + LREIKIL+ KHE Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHE 69 Query: 77 NVVNLIEICRTKA-SPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N++ + I R + +N +Y++ + + DL ++S ++ + I+ + L Sbjct: 70 NIITIFNIQRPDSFENFN----EVYIIQELMQTDLHRVISTQML--SDDHIQYFIYQTLR 123 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQP----NRYTNRV 189 + +H + ++HRD+K +N+LI + LK+ DFGLAR S A NS+P + T V Sbjct: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T WYR PE++L Y +D+W GCI+AE++ R PI G +HQL LI + G T Sbjct: 184 ATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIG--T 241 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRL-KAYVR-DPYALDLIDKLLVLDPAQRIDSD 307 P ++ E E +K L K + R +P +DL+ ++LV DPA+RI + Sbjct: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Query: 308 DALNHDFFWSDPMPSD 323 +AL H + + P+D Sbjct: 302 EALEHPYLQTYHDPND 317 >3OZ6-A nrPDB Length = 388 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 112/332 (33%), Positives = 175/332 (52%), Gaps = 45/332 (13%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHE 76 KYE + K+G+G +G V+K+ R+TG+ VA+KK+ + REI IL +L HE Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHE 69 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLLN 135 N+VNL+ + R +YLVFD+ E DL ++ +N+L + V+ L+ Sbjct: 70 NIVNLLNVLRADND------RDVYLVFDYMETDLHAVIRANILEPV---HKQYVVYQLIK 120 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF------------SLAKNS--- 180 + Y+H +LHRDMK +N+L+ + +K+ADFGL+R+F S+ +N+ Sbjct: 121 VIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENF 180 Query: 181 ---QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 QP T+ V T WYR PE+LLG Y ID+W GCI+ E+ PI G++ +Q Sbjct: 181 DDDQP-ILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQ 239 Query: 238 LALISQLCGSITPEVWPNVDN-------YELYEKLELVKGQKRKVKDRLKAYVR------ 284 L I + + E ++ + L EK+E+ + KR + + K + Sbjct: 240 LERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKA 299 Query: 285 --DPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 + ALDL+DKLL +P +RI ++DAL H F Sbjct: 300 DCNEEALDLLDKLLQFNPNKRISANDALKHPF 331 >1CM8-A nrPDB Length = 367 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 102/301 (33%), Positives = 156/301 (51%), Gaps = 16/301 (5%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y L +G G +G V A +TG KVA+KK+ + E F A RE+++L+ ++HENV Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + L+++ + + YLV F DL L+ + K I+ ++ +L GL Sbjct: 87 IGLLDVFTPDETLDDFT--DFYLVMPFMGTDLGKLMKHE--KLGEDRIQFLVYQMLKGLR 142 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 YIH I+HRD+K N+ + D LK+ DFGLAR + T VVT WYR PE Sbjct: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-------QADSEMTGYVVTRWYRAPE 195 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 ++L Y +D+W GCIMAEM T + +G+ QL I ++ G+ E V Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF---VQR 252 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRD--PYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 + E +KG K + + + P A++L++K+LVLD QR+ + +AL H +F Sbjct: 253 LQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFE 312 Query: 317 S 317 S Sbjct: 313 S 313 >6DTL-A nrPDB Length = 364 Score = 159 bits (402), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 102/305 (33%), Positives = 159/305 (52%), Gaps = 16/305 (5%) Query: 16 VSKYEK-LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 +KY+ + IG+G +G V A + +T + VA+KK+ + + LREIK+L+ + Sbjct: 28 TAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMD 87 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQM 132 HEN+V + +I P +Y+ ++ + DL ++ + LSE + + Sbjct: 88 HENIVAIRDII---PPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSEEHCQYFLYQ 141 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +L GL YIH +LHRD+K +N+L+ + LK+ DFGLAR S+ + T VVT Sbjct: 142 ILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-----TSESDFMTEYVVTR 196 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 WYR PELLL DY ID+W GCI E+ R P+ G HQL L+ +L G+ + E Sbjct: 197 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 256 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 ++ +L ++ + D+ P A+DLI+K+L DP +RI DAL H Sbjct: 257 LEFLNENAKRYIRQLPPYPRQSITDKFPTV--HPLAIDLIEKMLTFDPRRRITVLDALAH 314 Query: 313 DFFWS 317 + S Sbjct: 315 PYLNS 319 >5Z33-A nrPDB Length = 425 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 101/304 (33%), Positives = 152/304 (50%), Gaps = 9/304 (2%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HE 76 +Y ++GQG +G V A + +T + VA+KKV K+ ALREIK+LQ + H Sbjct: 32 RYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHR 91 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 N+ L ++ + +N YL + E DLA ++ + T + + + +L G Sbjct: 92 NITCLYDMDIPRPDNFN----ETYLYEELMECDLAAIIRSGQ-PLTDAHFQSFIYQILCG 146 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 L YIH +LHRD+K N+L+ D LK+ DFGLAR FS+ T V T WYR Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 PE++L + Y ID+W GCI+AE+ P +G QL I + G+ E + Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF- 315 + E + + +K L +P ALDL+D++L DP+ RI + AL H + Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNA-NPDALDLLDRMLAFDPSSRISVEQALEHPYLH 325 Query: 316 -WSD 318 W D Sbjct: 326 IWHD 329 >4MYG-A nrPDB Length = 372 Score = 157 bits (397), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 99/298 (33%), Positives = 158/298 (53%), Gaps = 17/298 (5%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G +G V A +++G+KVA+KK+ + E F A RE+ +L+ ++HENV+ L+++ Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNK 144 +S N YLV F + DL ++ ++F+ +I+ ++ +L GL YIH Sbjct: 111 FTPASSLRNFY--DFYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 145 ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER 204 ++HRD+K N+ + D LK+ DFGLAR T VVT WYR PE++L Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYRAPEVILSWM 218 Query: 205 DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEK 264 Y +D+W GCIMAEM T + +G QL I ++ G E +++ Sbjct: 219 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 278 Query: 265 LELVKGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDPAQRIDSDDALNHDFF--WSDP 319 ++ + R KD + + R P A DL++K+L LD +R+ + AL H FF + DP Sbjct: 279 IQSLPQTPR--KDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDP 334 >4CRL-A nrPDB Length = 406 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 112/340 (32%), Positives = 176/340 (51%), Gaps = 45/340 (13%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKV--ALKKVLMENEKEGFPITALREIKILQ 71 +++ +YE K+G+GT+G V+KA+ + ALK++ E G ++A REI +L+ Sbjct: 20 EDLFEYEG-CKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLR 74 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL--------AGLLSNVLVKFTL 123 LKH NV++L ++ + A ++L+FD+ EHDL A + V+ Sbjct: 75 ELKHPNVISLQKVFLSHAD------RKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPR 128 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKN 179 +K ++ +L+G++Y+H N +LHRD+K AN+L+ +G +K+AD G AR F+ Sbjct: 129 GMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLK 188 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE----- 234 + VVT WYR PELLLG R Y ID+W GCI AE+ T PI E Sbjct: 189 PLAD-LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTS 247 Query: 235 ----QHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRK-------VKDRLKAYV 283 QL I + G + W ++ ++ E L+K +R +K K V Sbjct: 248 NPYHHDQLDRIFNVMGFPADKDWEDIK--KMPEHSTLMKDFRRNTYTNCSLIKYMEKHKV 305 Query: 284 R-DPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPS 322 + D A L+ KLL +DP +RI S+ A+ +F DP+P+ Sbjct: 306 KPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPT 345 >4QTB-A nrPDB Length = 380 Score = 155 bits (392), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 106/313 (33%), Positives = 159/313 (50%), Gaps = 9/313 (2%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 PF D +Y +L IG+G +G V A +VA+KK+ E + + LREI+IL Sbjct: 36 PF-DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQIL 93 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM 130 +HENV+ + +I R R +Y+V D E DL LL + + + I + Sbjct: 94 LRFRHENVIGIRDILRASTLEAMR---DVYIVQDLMETDLYKLLKSQ--QLSNDHICYFL 148 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +L GL YIH +LHRD+K +N+LI LK+ DFGLAR + ++ T V Sbjct: 149 YQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVA 207 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T WYR PE++L + Y ID+W GCI+AEM + PI G QL I + GS + Sbjct: 208 TRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 267 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E + N + L+ + + + +L D ALDL+D++L +P +RI ++AL Sbjct: 268 EDLNCIINMKARNYLQSLPSKTKVAWAKLFP-KSDSKALDLLDRMLTFNPNKRITVEEAL 326 Query: 311 NHDFFWSDPMPSD 323 H + P+D Sbjct: 327 AHPYLEQYYDPTD 339 >5NGU-A nrPDB Length = 381 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 105/306 (34%), Positives = 153/306 (50%), Gaps = 8/306 (2%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y L+ IG+G +G V A +VA+KK+ E + + LREIKIL +HEN Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHEN 101 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 ++ + +I R +P +Y+V D E DL LL + I + +L GL Sbjct: 102 IIGINDIIR---APTIEQMKDVYIVQDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGL 156 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 YIH +LHRD+K +N+L+ LK+ DFGLAR + T V T WYR P Sbjct: 157 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD-PDHDHTGFLTEYVATRWYRAP 215 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E++L + Y ID+W GCI+AEM + PI G QL I + GS + E + Sbjct: 216 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 275 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 N + L + + + +RL D ALDL+DK+L +P +RI+ + AL H + Sbjct: 276 NLKARNYLLSLPHKNKVPWNRLFPNA-DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 318 DPMPSD 323 PSD Sbjct: 335 YYDPSD 340 >3OHT-A nrPDB Length = 389 Score = 155 bits (391), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 100/309 (32%), Positives = 162/309 (52%), Gaps = 24/309 (7%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y+ L+ +G G +G V + K+G K+A+KK+ + RE+++L+ +KHEN Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 111 Query: 78 VVNLIEICR--TKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQML 133 V+ L+++ T +N +YLV H + L+N++ K T ++ ++ + Sbjct: 112 VIGLLDVFTPATSLEEFN----DVYLV----THLMGADLNNIVKCQKLTDDHVQFLIYQI 163 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L GL YIH I+HRD+K +N+ + D LK+ DFGLAR + T V T W Sbjct: 164 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRW 216 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PE++L Y +D+W GCIMAE+ T + G +QL I +L G+ V Sbjct: 217 YRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVI 276 Query: 254 PNVDNYELYEKL-ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 + ++E + L + KR D +P A+DL++K+LVLD +RI + +AL H Sbjct: 277 SRMPSHEARNYINSLPQMPKRNFADVFIG--ANPLAVDLLEKMLVLDTDKRITASEALAH 334 Query: 313 DFF--WSDP 319 +F + DP Sbjct: 335 PYFSQYHDP 343 >2I6L-A nrPDB Length = 320 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 115/327 (35%), Positives = 165/327 (50%), Gaps = 44/327 (13%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S+Y L +G G G VF A ++VA+KK+++ + + ALREIKI++ L H+ Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS--VKHALREIKIIRRLDHD 68 Query: 77 NVVNLIEICRTKASPYNRCKGS------IYLVFDFCEHDLAGLLSNVLVKFTLSE--IKR 128 N+V + EI S GS +Y+V ++ E DLA NVL + L E + Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLA----NVLEQGPLLEEHARL 124 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLI-TRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 M LL GL YIH +LHRD+K AN+ I T D VLK+ DFGLAR S + Sbjct: 125 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD-PHYSHKGHLSE 183 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI------ 241 +VT WYR P LLL +Y ID+W AGCI AEM T + G E Q+ LI Sbjct: 184 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPV 243 Query: 242 -----SQLCGSITPEVWPNVDNYELYEKL-ELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 Q S+ P V+ D E ++ L +L+ G R+ A+D ++++ Sbjct: 244 VHEEDRQELLSVIP-VYIRNDMTEPHKPLTQLLPGISRE-------------AVDFLEQI 289 Query: 296 LVLDPAQRIDSDDALNHDF--FWSDPM 320 L P R+ +++AL+H + +S PM Sbjct: 290 LTFSPMDRLTAEEALSHPYMSIYSFPM 316 >4EWQ-A nrPDB Length = 383 Score = 152 bits (383), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 100/309 (32%), Positives = 160/309 (51%), Gaps = 24/309 (7%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y+ L+ +G G +G V A KTG +VA+KK+ + RE+++L+ +KHEN Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHEN 105 Query: 78 VVNLIEICRTKAS--PYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQML 133 V+ L+++ S +N +YLV H + L+N++ K T ++ ++ + Sbjct: 106 VIGLLDVFTPARSLEEFN----DVYLV----THLMGADLNNIVKCQKLTDDHVQFLIYQI 157 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L GL YIH I+HRD+K +N+ + D LK+ DFGLAR + T V T W Sbjct: 158 LRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRW 210 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PE++L Y +D+W GCIMAE+ T + G QL LI +L G+ E+ Sbjct: 211 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 270 Query: 254 PNVDNYELYEKLE-LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 + + ++ L + K + +P A+DL++K+LVLD +RI + AL H Sbjct: 271 KKISSESARNYIQSLTQMPKMNFANVFIG--ANPLAVDLLEKMLVLDSDKRITAAQALAH 328 Query: 313 DFF--WSDP 319 +F + DP Sbjct: 329 AYFAQYHDP 337 >3GC9-A nrPDB Length = 370 Score = 150 bits (379), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 98/308 (31%), Positives = 159/308 (51%), Gaps = 22/308 (7%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 + + L +G G +G V A + QKVA+KK+ + RE+++L+ LKHEN Sbjct: 29 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHEN 88 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLN 135 V+ L+++ S + + +YLV DL +N++ LS+ ++ ++ LL Sbjct: 89 VIGLLDVFTPATSIEDFSE--VYLVTTLMGADL----NNIVKSQALSDEHVQFLVYQLLR 142 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL YIH I+HRD+K +NV + D L++ DFGLAR T V T WYR Sbjct: 143 GLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLAR-------QADEEMTGYVATRWYR 195 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++L Y +D+W GCIMAE+ + G+ QL I ++ G+ +PEV Sbjct: 196 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 255 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVR--DPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + + ++ + +K L + R +P A+DL+ ++LVLD QR+ + +AL H Sbjct: 256 ISSEHARTYIQSLPPMPQK---DLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA 312 Query: 314 FF--WSDP 319 +F + DP Sbjct: 313 YFSQYHDP 320 >4O2Z-A nrPDB Length = 377 Score = 149 bits (377), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 95/315 (30%), Positives = 159/315 (50%), Gaps = 14/315 (4%) Query: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV--LMENEKEGFP 60 K Y+ PF + SKY L +G G +G TG+KV++KK + + ++G Sbjct: 32 KVYNVSGSPF-EVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 + LREI +++ HEN++N++ I Y+ + +Y+V + D+ +L + V Sbjct: 91 V--LREIDMMRFFHHENLLNVVNILPPLKREYHSFE-DVYVVTPLMDVDMNVVLRSRQV- 146 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 S ++ + +L GL Y+H + HRD+K AN++ LK+ DFGL+R+ + + Sbjct: 147 LEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYS- 205 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 T+ V+T WYRPPELLL +Y +D+W GCI AEM+ R P+ G QL + Sbjct: 206 ---ELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRM 262 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 I+Q G + V++ E EKL + + + + +D + K+ LDP Sbjct: 263 IAQHIGKPPASI---VEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDP 319 Query: 301 AQRIDSDDALNHDFF 315 ++R + D L H + Sbjct: 320 SKRPTAADMLAHPYL 334 >4QNY-A nrPDB Length = 354 Score = 140 bits (354), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 97/293 (33%), Positives = 151/293 (51%), Gaps = 11/293 (3%) Query: 25 IGQGTFGEVFKARHRKTGQK-VALKKVLME-NEKEGFPITALREIKILQLLKHENVVNLI 82 IG G++G V +AR K+ + VA+K+V E E+ LREIK+L +N++ L Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142 I T P N Y+V D E DL +L + + T + I+ + L L+ IH Sbjct: 88 NIL-TPEDPENF--DHFYIVMDIMETDLKQVLRSGQ-ELTEAHIQFFIYQALRALHIIHS 143 Query: 143 NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG 202 ++HRD+ AN+L+ + LK+ DFGLA+ +N Q T+ V WYR PEL++ Sbjct: 144 AGVIHRDITPANILVNTNCDLKICDFGLAKE----ENDQGEYMTDYVTMRWYRAPELVME 199 Query: 203 ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELY 262 ++DY ID+WG GCI+ E+ P+ QG +QL I + G+ + E +V + Sbjct: 200 DKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQ 259 Query: 263 EKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + L+ K + + R + P ALDL+ +LV +P +RI A+ H F Sbjct: 260 KYLK-KKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFL 311 >3PG1-A nrPDB Length = 362 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 97/326 (29%), Positives = 157/326 (48%), Gaps = 26/326 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT----------ALRE 66 S Y I G++G V + G VA+K+V +G + LRE Sbjct: 22 SPYTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVF-NTVSDGRTVNILSDSFLCKRVLRE 79 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI 126 I++L H N++ L +I P +YLV + DLA ++ + + + I Sbjct: 80 IRLLNHFHHPNILGLRDIFVHFEEP---AMHKLYLVTELMRTDLAQVIHDQRIVISPQHI 136 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + M +L GL+ +H ++HRD+ N+L+ + + + DF LAR + N T Sbjct: 137 QYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANK-----T 191 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + V WYR PEL++ + + +D+W AGC+MAEM+ R + +G+T +QL I ++ G Sbjct: 192 HYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVG 251 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV---RDPYALDLIDKLLVLDPAQR 303 TP++ +V + + ++ V R V DP ALDLI K+L +P +R Sbjct: 252 --TPKI-EDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRR 308 Query: 304 IDSDDALNHDFFWSDPMPSDLKGMLS 329 I ++ AL H +F S P DL LS Sbjct: 309 ISTEQALRHPYFESLFDPLDLTEGLS 334 >3N9X-A nrPDB Length = 432 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 99/339 (29%), Positives = 164/339 (48%), Gaps = 55/339 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 IG+G++G V+ A + T + VA+KKV E LREI IL LK + ++ L ++ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 85 CRTKASPYNRCK-GSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 P + K +Y+V + + DL L + T IK ++ LL G +IH + Sbjct: 94 I----IPDDLLKFDELYIVLEIADSDLKKLFKTPIF-LTEEHIKTILYNLLLGENFIHES 148 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFS----------LAKNSQPNRY-------- 185 I+HRD+K AN L+ +D +K+ DFGLAR + L +N +P + Sbjct: 149 GIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQL 208 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW-----------TRSPIMQGN-- 232 T+ VVT WYR PEL+L + +Y ID+W GCI AE+ R P+ G+ Sbjct: 209 TSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSC 268 Query: 233 ---------------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKR-KVK 276 + + QL +I + G+ T + N++ E+ + ++L +K +K Sbjct: 269 FPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLK 328 Query: 277 DRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + + D ++L++ +L +P +RI D AL+H + Sbjct: 329 QKYPSISDD--GINLLESMLKFNPNKRITIDQALDHPYL 365 >3E7O-A nrPDB Length = 360 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 95/327 (29%), Positives = 158/327 (48%), Gaps = 37/327 (11%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y++L IG G G V A G VA+KK+ + + A RE+ +L+ + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+++L+ + + + +YLV + + A L + ++ + ++ +L Sbjct: 81 KNIISLLNVFTPQKTLEEF--QDVYLVMELMD---ANLCQVIHMELDHERMSYLLYQMLC 135 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR S P VVT +YR Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTP-----YVVTRYYR 190 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE---- 251 PE++LG Y +D+W GCIM E+ S I QG Q + + G+ + E Sbjct: 191 APEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAA 249 Query: 252 VWPNVDNY-------------ELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 + P V NY EL+ +R D++K A DL+ K+LV+ Sbjct: 250 LQPTVRNYVENRPAYPGIAFEELFPDWIFPSESER---DKIKT----SQARDLLSKMLVI 302 Query: 299 DPAQRIDSDDALNHDFF--WSDPMPSD 323 DP +RI D+AL H + W DP ++ Sbjct: 303 DPDKRISVDEALRHPYITVWYDPAEAE 329 >1JNK-A nrPDB Length = 423 Score = 128 bits (321), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 92/316 (29%), Positives = 152/316 (48%), Gaps = 23/316 (7%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+++L+ + + + +YLV + + A L + ++ + ++ +L Sbjct: 121 KNIISLLNVFTPQKTLEEF--QDVYLVMELMD---ANLCQVIQMELDHERMSYLLYQMLC 175 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR + P VVT +YR Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP-----YVVTRYYR 230 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE---- 251 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 231 APEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 Query: 252 VWPNVDNY----ELYEKLELVKGQKRKV--KDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 + P V NY Y L K + D ++ A DL+ K+LV+DPA+RI Sbjct: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 Query: 306 SDDALNHDFF--WSDP 319 DDAL H + W DP Sbjct: 350 VDDALQHPYINVWYDP 365 >3RP9-A nrPDB Length = 458 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 103/360 (28%), Positives = 160/360 (44%), Gaps = 75/360 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +YE IG G++G V +A + + VA+KK+L E LREI IL L H++ Sbjct: 54 RYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDH 113 Query: 78 VVNLIEICRTK-ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 VV +++I K ++ +Y+V + + D L V T IK ++ LL G Sbjct: 114 VVKVLDIVIPKDVEKFD----ELYVVLEIADSDFKKLF-RTPVYLTELHIKTLLYNLLVG 168 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN------------- 183 + Y+H ILHRD+K AN L+ +D +K+ DFGLAR +N Sbjct: 169 VKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLV 228 Query: 184 ----------RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT--------- 224 + T VVT WYR PEL+L + +Y ID+W GCI AE+ Sbjct: 229 TFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYH 288 Query: 225 --RSPIMQGNT--------------------EQHQLALISQLCGSITPEVWPNVDNYELY 262 R P+ G++ + QL +I + G+ P+ ++ E Sbjct: 289 ADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGT------PSEEDIEAL 342 Query: 263 EKLE-------LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 EK + K + + +R A D A+ L+ ++LV +P +RI ++ L H FF Sbjct: 343 EKEDAKRYIRIFPKREGTDLAERFPASSAD--AIHLLKRMLVFNPNKRITINECLAHPFF 400 >5ZTN-A nrPDB Length = 429 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 104/342 (30%), Positives = 161/342 (47%), Gaps = 49/342 (14%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Q V+ P +YE L IG+G+FG+V KA K Q VALK ++ NEK F A Sbjct: 84 QGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK--MVRNEKR-FHRQA 140 Query: 64 LREIKILQLLKHE---NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLV 119 EI+IL+ L+ + N +N+I + + I + F+ +L L+ N Sbjct: 141 AEEIRILEHLRKQDKDNTMNVIHMLENFT-----FRNHICMTFELLSMNLYELIKKNKFQ 195 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLA 177 F+L +++ +L L +H+N+I+H D+K N+L+ + G +K+ DFG + Sbjct: 196 GFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG-------S 248 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 + R + + +YR PE++LG R YG PID+W GCI+AE+ T P++ G E Q Sbjct: 249 SCYEHQRVYTYIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQ 307 Query: 238 LALISQLCG---------SITPEVWPNVDNYELY--------EKLELVKGQKRKVKDRLK 280 LA + +L G S + + + Y Y + L G+ R+ K R Sbjct: 308 LACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGP 367 Query: 281 AYVR----------DPYALDLIDKLLVLDPAQRIDSDDALNH 312 R DP LD + + L DPA R+ AL H Sbjct: 368 PESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRH 409 >5AIR-A nrPDB Length = 430 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 99/308 (32%), Positives = 148/308 (48%), Gaps = 27/308 (8%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 EVS Y IG G+FG V++A+ +G+ VA+KKVL + + RE++I++ L Sbjct: 63 EVS-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLD 115 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYL--VFDFCE---HDLAGLLSNVLVKFTLSEIKRV 129 H N+V L + K +YL V D+ + +A S + +K Sbjct: 116 HCNIVRLRYFFYSSGEK----KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLY 171 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNR 188 M L L YIH I HRD+K N+L+ D VLKL DFG A+ +PN + Sbjct: 172 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLV---RGEPN--VSY 226 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 + + +YR PEL+ G DY ID+W AGC++AE+ PI G++ QL I ++ G+ Sbjct: 227 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 286 Query: 249 TPEVWPNVD-NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 T E ++ NY + K +K R + P A+ L +LL P R+ Sbjct: 287 TREQIREMNPNYTEF-KFPQIKAHPWTKVFRPRT---PPEAIALCSRLLEYTPTARLTPL 342 Query: 308 DALNHDFF 315 +A H FF Sbjct: 343 EACAHSFF 350 >5AWM-A nrPDB Length = 394 Score = 124 bits (310), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 95/327 (29%), Positives = 151/327 (46%), Gaps = 48/327 (14%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S+Y L IG G G V A T Q VA+KK+ + A RE K+++L+ H+ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 103 Query: 77 NVVNLIEICRTKASPYNRCK--GSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 N++ L+ +P + +YLV + + A L + + + ++ +L Sbjct: 104 NIIGLL----NAFTPQRNLEEFQDVYLVMELMD---ANLCQVIQMDLDHDRMSYLLYQML 156 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR P VVT +Y Sbjct: 157 CGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTP-----YVVTRYY 211 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE--- 251 R PE++LG Y +D+W GCIM EM + G Q I + G+ +P Sbjct: 212 RAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQ 270 Query: 252 -VWPNVDNY---------ELYEKL--------ELVKGQKRKVKDRLKAYVRDPYALDLID 293 + P V NY +++L + + +RK D A +L+ Sbjct: 271 RLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----------ARNLLS 320 Query: 294 KLLVLDPAQRIDSDDALNHDFF--WSD 318 K+LV+DP QRI D+AL H++ W D Sbjct: 321 KMLVIDPEQRISVDEALKHEYINVWYD 347 >3FI2-A nrPDB Length = 353 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 89/310 (28%), Positives = 149/310 (48%), Gaps = 21/310 (6%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+++L+ + + + +YLV + + A L + ++ + ++ +L Sbjct: 83 KNIISLLNVFTPQKTLEEF--QDVYLVMELMD---ANLCQVIQMELDHERMSYLLYQMLC 137 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR + P VVT +YR Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTP-----YVVTRYYR 192 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE---- 251 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 193 APEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 251 Query: 252 VWPNVDNY----ELYEKLELVKGQKRKV--KDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 + P V NY Y L K + D ++ A DL+ K+LV+DPA+RI Sbjct: 252 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 311 Query: 306 SDDALNHDFF 315 DDAL H + Sbjct: 312 VDDALQHPYI 321 >4E7W-A nrPDB Length = 394 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 91/301 (30%), Positives = 149/301 (49%), Gaps = 21/301 (6%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y IG G+FG VF+A+ ++ + VA+KKVL + + RE++I++++KH NV Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDL---AGLLSNVLVKFTLSEIKRVMQMLLN 135 V+L + + + LV ++ + + + + + IK M LL Sbjct: 95 VDLKAFFYSNGDKKDEV--FLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 136 GLYYIHRNKILHRDMKAANVLI-TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 L YIH I HRD+K N+L+ GVLKL DFG A+ +PN + + + +Y Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAG---EPN--VSYICSRYY 207 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 R PEL+ G +Y ID+W GC+MAE+ P+ G + QL I ++ G+ + E Sbjct: 208 RAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIK 267 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 ++ + K ++ R + P A+DLI +LL P+ R+ + +AL H F Sbjct: 268 TMNPNYMEHKFPQIRPHPFSKVFRPRT---PPDAIDLISRLLEYTPSARLTAIEALCHPF 324 Query: 315 F 315 F Sbjct: 325 F 325 >3E3P-A nrPDB Length = 360 Score = 120 bits (301), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 109/361 (30%), Positives = 162/361 (44%), Gaps = 68/361 (18%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ--- 71 E+ +++ GQGTFG V + + TG VA+KKV+ + P RE++I+Q Sbjct: 21 EMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD------PRFRNRELQIMQDLA 74 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYL--VFDFCEHDLAGLLSN----------VLV 119 +L H N+V L T R + IYL V ++ L N +L+ Sbjct: 75 VLHHPNIVQLQSYFYTLGE---RDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILI 131 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR-DGVLKLADFGLARAFSLAK 178 K L ++ R + G ++ + HRD+K NVL+ DG LKL DFG A+ S Sbjct: 132 KVFLFQLIRSI-----GCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS--- 183 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 S+PN + + +YR PEL+ G + Y +D+W GCI AEM PI +G+ QL Sbjct: 184 PSEPN--VAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQL 241 Query: 239 ALISQLCGSITPEVW----PNVDNYELYEKLELVKG-------QKRKVKDRLKAYVRDPY 287 I ++ G + EV P+ + +LY KG +KD +AY Sbjct: 242 HEIVRVLGCPSREVLRKLNPSHTDVDLYNS----KGIPWSNVFSDHSLKDAKEAY----- 292 Query: 288 ALDLIDKLLVLDPAQRIDSDDALNHDFF--WSDP---------MPSDLKGMLSTHLTSMF 336 DL+ LL P +R+ +AL H +F DP +P DL L + M Sbjct: 293 --DLLSALLQYLPEERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMS 350 Query: 337 E 337 E Sbjct: 351 E 351 >2XS0-A nrPDB Length = 386 Score = 119 bits (297), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 87/320 (27%), Positives = 147/320 (45%), Gaps = 31/320 (9%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N++ L+ + + S +Y+V + + A L + ++ + ++ +L Sbjct: 85 KNIIGLLNVFTPQKSLEEF--QDVYIVMELMD---ANLCQVIQMELDHERMSYLLYQMLC 139 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR + P VVT +YR Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVP-----FVVTRYYR 194 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW-- 253 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 195 APEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK 253 Query: 254 ------------PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P Y + V ++LKA A DL+ K+LV+D + Sbjct: 254 LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKA----SQARDLLSKMLVIDAS 309 Query: 302 QRIDSDDALNHDFF--WSDP 319 +RI D+AL H + W DP Sbjct: 310 KRISVDEALQHPYINVWYDP 329 >5Y86-A nrPDB Length = 588 Score = 117 bits (293), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 99/325 (30%), Positives = 153/325 (47%), Gaps = 43/325 (13%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +YE L IG+G+FG+V + K Q VALK ++ NEK F A EI+IL+ LK ++ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALK--MVRNEKR-FHRQAAEEIRILEHLKKQD 264 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLLNG 136 + + S R + + F+ DL L+ N F++ +++ Q +L Sbjct: 265 KTGSMNVIHMLESFTFR--NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQS 322 Query: 137 LYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 L +H+NKI+H D+K N+L+ G K+ DFG + F K YT + + +Y Sbjct: 323 LDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQK-----LYT-YIQSRFY 375 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 R PE++LG R Y PID+W GCI+AE+ T P+ G E QLA + +L G P++ Sbjct: 376 RAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Query: 255 NVDNYELY-----------------EKLELVKGQKRKVKDRLKAYVRD-PYALDLIDKLL 296 + + ++ LV G+ R+ K R +D AL D L Sbjct: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Query: 297 VL---------DPAQRIDSDDALNH 312 + DP+ R+ AL H Sbjct: 495 FIEFLKRCLHWDPSARLTPAQALRH 519 >3NIE-A nrPDB Length = 429 Score = 114 bits (285), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 97/348 (27%), Positives = 155/348 (44%), Gaps = 58/348 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 YE IG+G++G V+ A + + VA+KKV E LREI IL LK + + Sbjct: 30 YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYI 89 Query: 79 VNLIEICRTKASPYNRCK-GSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + L ++ P + K +Y+V + + DL L + T +K ++ LL G Sbjct: 90 IRLHDLI----IPEDLLKFDELYIVLEIADSDLKKLFKTPIF-LTEQHVKTILYNLLLGE 144 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ---------------- 181 +IH + I+HRD+K AN L+ +D +K+ DFGLAR + K+ Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 182 -----PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW-----------TR 225 + T+ VVT WYR PEL+L + +Y ID+W GCI AE+ R Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 226 SPIMQGN-----------------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELV 268 P+ G+ + + QL +I + G+ E + E+ + ++L Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 269 KGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 R D K Y +DL++ +L + +RI D AL+H + Sbjct: 325 PT--RDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYL 370 >3NCG-A nrPDB Length = 486 Score = 114 bits (284), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 92/341 (26%), Positives = 159/341 (46%), Gaps = 67/341 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y + +G+G+FGEV K + R T Q+ A+K + + K T LRE+++L+ L H N Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPN 82 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLL 134 ++ L EI +S Y G +Y G L + ++K F+ + R+++ + Sbjct: 83 IMKLFEILEDSSSFY--IVGELY---------TGGELFDEIIKRKRFSEHDAARIIKQVF 131 Query: 135 NGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +G+ Y+H++ I+HRD+K N+L+ +D +K+ DFGL+ F Q + +R+ T Sbjct: 132 SGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCF-----QQNTKMKDRIGT 186 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y PE+L G Y D+W AG I+ + + +P G E Sbjct: 187 AYYIAPEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNE----------------- 227 Query: 252 VWPNVDNYELYEKLELVK-----GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 Y++ +++E K Q R + D K DLI K+L P+ RI + Sbjct: 228 -------YDILKRVETGKYAFDLPQWRTISDDAK---------DLIRKMLTFHPSLRITA 271 Query: 307 DDALNH----DFFWSDPMPSDLKGMLSTHLTSMFEYLAPPR 343 L H + P SDL L + +T++ ++ A + Sbjct: 272 TQCLEHPWIQKYSSETPTISDLPS-LESAMTNIRQFQAEKK 311 >3EB0-A nrPDB Length = 383 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 87/333 (26%), Positives = 153/333 (45%), Gaps = 50/333 (15%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 KY +G G+FG V + ++G++ ALKKVL + P RE+ I+++L H N Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHVN 61 Query: 78 VVNLIEICRTKASP----------YNRCKGS--------------------IYLVFDFCE 107 ++ L++ T +N+ G + ++ ++ Sbjct: 62 IIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVP 121 Query: 108 HDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI-TRDGVL 163 L +L + + ++ I + L + +IH I HRD+K N+L+ ++D L Sbjct: 122 DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTL 181 Query: 164 KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW 223 KL DFG A+ ++ S + + +YR PEL+LG +Y P IDLW GC+ E+ Sbjct: 182 KLCDFGSAKKLIPSEPS-----VAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI 236 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK-RKVKDRLKAY 282 P+ G T QL I Q+ G+ T E ++ + + +K + RK+ Sbjct: 237 LGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPS 296 Query: 283 VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + A+DL++++L +P RI+ +A+ H FF Sbjct: 297 L----AIDLLEQILRYEPDLRINPYEAMAHPFF 325 >3DFA-A nrPDB Length = 286 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 85/306 (27%), Positives = 144/306 (47%), Gaps = 62/306 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y + +G+G+FGEV K + R T Q+ A+K + + K T LRE+++L+ L H N Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPN 82 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLL 134 ++ L EI +S Y G +Y G L + ++K F+ + R+++ + Sbjct: 83 IMKLFEILEDSSSFY--IVGELY---------TGGELFDEIIKRKRFSEHDAARIIKQVF 131 Query: 135 NGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +G+ Y+H++ I+HRD+K N+L+ +D +K+ DFGL+ F Q + +R+ T Sbjct: 132 SGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCF-----QQNTKMKDRIGT 186 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y PE+L G Y D+W AG I+ + + +P G E Sbjct: 187 AYYIAPEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNE----------------- 227 Query: 252 VWPNVDNYELYEKLELVK-----GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 Y++ +++E K Q R + D K DLI K+L P+ RI + Sbjct: 228 -------YDILKRVETGKYAFDLPQWRTISDDAK---------DLIRKMLTFHPSLRITA 271 Query: 307 DDALNH 312 L H Sbjct: 272 TQCLEH 277 >6O6Q-A nrPDB Length = 335 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 94/310 (30%), Positives = 155/310 (50%), Gaps = 30/310 (9%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ-LLKHEN 77 YE L K+G+G + EVF + +KV +K VL +++ REI IL+ L+ N Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIK-VLKPVKRKKIK----REISILKNLVDGPN 97 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 ++ ++++ R P ++ G I+ EH ++ FT +I+ M LL L Sbjct: 98 IIAMLDVVR---EPQSKTPGLIF------EHINNIDFRSLYPTFTDYDIRFYMYELLKAL 148 Query: 138 YYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Y H I+HRD+K NV+I D +L+L D+GLA + Y RV + +++ Sbjct: 149 DYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPG-----TEYNVRVASRYFKG 203 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PELL+ R Y +D+W GC++A M + + P G + QL I ++ GS + + Sbjct: 204 PELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLE 263 Query: 256 VDNYELYEKLELV-----KGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 N L E+ E + + R + + K V + LDLID+LL D +R+ + +A+ Sbjct: 264 KYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEF-LDLIDRLLRYDHQERLTAKEAM 322 Query: 311 NHDFFWSDPM 320 H +F DP+ Sbjct: 323 KHAYF--DPI 330 >3MA6-A nrPDB Length = 298 Score = 110 bits (276), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 87/307 (28%), Positives = 152/307 (49%), Gaps = 59/307 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQL 72 +Y+ +G+G+FGEV + + TGQ+ A+K +V + +KE + LRE+++L+ Sbjct: 33 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE----SLLREVQLLKQ 88 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI--KRVM 130 L H N++ L E K G YLV + + L ++ + SE+ R++ Sbjct: 89 LDHPNIMKLYEFFEDK--------GYFYLVGEV--YTGGELFDEIISRKRFSEVDAARII 138 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 + +L+G+ Y+H+NKI+HRD+K N+L+ ++D +++ DFGL+ F +K + + Sbjct: 139 RQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK-----KMKD 193 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 ++ T +Y PE+L G Y D+W G I+ + + P G E L + + G Sbjct: 194 KIGTAYYIAPEVLHG--TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK--GK 249 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 T E+ Q +KV + K DLI K+L P+ RI + Sbjct: 250 YTFEL-----------------PQWKKVSESAK---------DLIRKMLTYVPSMRISAR 283 Query: 308 DALNHDF 314 DAL+H++ Sbjct: 284 DALDHEW 290 >5JN2-A nrPDB Length = 525 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 88/308 (28%), Positives = 153/308 (49%), Gaps = 59/308 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQL 72 +Y+ +G+G+FGEV + + TGQ+ A+K +V + +KE + LRE+++L+ Sbjct: 68 RYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKE----SLLREVQLLKQ 123 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVM 130 L H N++ L E K G YLV + + L ++ + SE+ R++ Sbjct: 124 LDHPNIMKLYEFFEDK--------GYFYLVGEV--YTGGELFDEIISRKRFSEVDAARII 173 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 + +L+G+ Y+H+NKI+HRD+K N+L+ ++D +++ DFGL+ F +K + + Sbjct: 174 RQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK-----KMKD 228 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 ++ T +Y PE+L G Y D+W G I+ + + P G E L + + G Sbjct: 229 KIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK--GK 284 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 T E+ P Q +KV + K DLI K+L P+ RI + Sbjct: 285 YTFEL-P----------------QWKKVSESAK---------DLIRKMLTYVPSMRISAR 318 Query: 308 DALNHDFF 315 DAL+H++ Sbjct: 319 DALDHEWI 326 >3MN3-A nrPDB Length = 271 Score = 107 bits (268), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 89/326 (27%), Positives = 149/326 (45%), Gaps = 71/326 (21%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK----KVLMENEKEGFPITALREIKIL 70 + Y+ + +G+G+FG+V A H TGQKVALK KVL +++ +G REI L Sbjct: 2 HIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQG---RIEREISYL 58 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM 130 +LL+H +++ L ++ ++K I +V ++ ++L + K + E +R Sbjct: 59 RLLRHPHIIKLYDVIKSK--------DEIIMVIEYAGNELFDYIVQ-RDKMSEQEARRFF 109 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA-----FSLAKNSQPNRY 185 Q +++ + Y HR+KI+HRD+K N+L+ +K+ADFGL+ F PN Sbjct: 110 QQIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPN-- 167 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 Y PE++ G+ GP +D+W G I+ M R + Sbjct: 168 --------YAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDES------------ 207 Query: 246 GSITPEVWPNVDN--YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 P ++ N+ N Y L + L P A LI ++L+++P R Sbjct: 208 ---IPVLFKNISNGVYTLPKFLS-------------------PGAAGLIKRMLIVNPLNR 245 Query: 304 IDSDDALNHDFFWSD----PMPSDLK 325 I + + D+F D +P DLK Sbjct: 246 ISIHEIMQDDWFKVDLPEYLLPPDLK 271 >4RGJ-A nrPDB Length = 520 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 85/317 (26%), Positives = 151/317 (47%), Gaps = 64/317 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLLKHE 76 +Y+ + +G+G+FGEV +R + TG + A+K + ++ K +L RE+++L++L H Sbjct: 61 QYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHI 120 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVMQMLL 134 N++ L E YLV D + L ++ + EI R+++ +L Sbjct: 121 NIMKLYEFFEDN--------NYYYLVSDV--YTGGELFDEIISRKRFYEIDAARIIKQIL 170 Query: 135 NGLYYIHRNKILHRDMKAANVLI----TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H+N ++HRD+K N+L+ D ++K+ DFGL+ F +K + +++ Sbjct: 171 SGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSK-----KMKDKIG 225 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y P++L G Y D+W G I+ + + P G+ E Sbjct: 226 TAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNE---------------- 267 Query: 251 EVWPNVDNYELYEKLELVKG-----QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 Y++ +K+E K Q +K+ D+ K DLI K+L+ A RI Sbjct: 268 --------YDILKKVEAGKYTFDLPQFKKISDKAK---------DLIKKMLMYTSAVRIS 310 Query: 306 SDDALNHDFFWSDPMPS 322 + DAL H+ W M S Sbjct: 311 ARDALEHE--WIKMMTS 325 >6HMD-A nrPDB Length = 365 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 95/340 (27%), Positives = 164/340 (48%), Gaps = 33/340 (9%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 P Y+ + K+G+G + EVF+A + ++V +K + +K+ + E Sbjct: 44 AHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILE- 102 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK 127 L N++ LI+ + S + LVF++ + L +L F +I+ Sbjct: 103 ---NLRGGTNIIKLIDTVKDPVSK------TPALVFEYINNTDFKQLYQILTDF---DIR 150 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYT 186 M LL L Y H I+HRD+K NV+I + L+L D+GLA + A+ Y Sbjct: 151 FYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ-----EYN 205 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLC 245 RV + +++ PELL+ + Y +D+W GC++A M + R P G QL I+++ Sbjct: 206 VRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL 265 Query: 246 GSITPEVWPNVDNY--ELYEKLELVKGQ--KRKVKDRLKAYVR---DPYALDLIDKLLVL 298 G T E++ + Y +L + GQ +++ ++ + + R P ALDL+DKLL Sbjct: 266 G--TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 323 Query: 299 DPAQRIDSDDALNHDFFW----SDPMPSDLKGMLSTHLTS 334 D QR+ + +A+ H +F+ PS +LS+ LT+ Sbjct: 324 DHQQRLTAKEAMEHPYFYPVVKEQSQPSADNAVLSSGLTA 363 >2PVN-A nrPDB Length = 352 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 84/308 (27%), Positives = 148/308 (48%), Gaps = 25/308 (8%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 E YE + K+G+G + EVF+ + +K +K + +K+ + L Sbjct: 50 EQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKK----IKREIKILQNLCG 105 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 N+V L++I R + S + L+F++ + +L L + +I+ + LL Sbjct: 106 GPNIVKLLDIVRDQHSK------TPSLIFEYVNNTDFKVLYPTLTDY---DIRYYIYELL 156 Query: 135 NGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L Y H I+HRD+K NV+I + L+L D+GLA + K Y RV + + Sbjct: 157 KALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGK-----EYNVRVASRY 211 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEV 252 ++ PELL+ +DY +D+W GC+ A M + + P G+ QL I+++ G+ Sbjct: 212 FKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNA 271 Query: 253 WPNVDNYELYEKLELVKGQKR-----KVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 + N EL +LE + G+ K + ++ P A+D +DKLL D +R+ + Sbjct: 272 YLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTAL 331 Query: 308 DALNHDFF 315 +A+ H +F Sbjct: 332 EAMTHPYF 339 >3DXN-A nrPDB Length = 287 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 141/305 (46%), Gaps = 59/305 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA-----LREIKILQL 72 +Y+++ K+G G +GEV + + TG + A+K + +K T+ L E+ +L+ Sbjct: 22 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKII----KKSSVTTTSNSGALLDEVAVLKQ 77 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR--VM 130 L H N++ L E K + YLV + + L ++++ SE+ +M Sbjct: 78 LDHPNIMKLYEFFEDKRN--------YYLVMEV--YRGGELFDEIILRQKFSEVDAAVIM 127 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 + +L+G Y+H++ I+HRD+K N+L+ +RD ++K+ DFGL+ F + + Sbjct: 128 KQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-----GKMKE 182 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 R+ T +Y PE+L + Y D+W G I+ + P G T+Q L + + S Sbjct: 183 RLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFS 240 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 P W V + A L+ +L +P++RI ++ Sbjct: 241 FDPPDWTQVSD----------------------------EAKQLVKLMLTYEPSKRISAE 272 Query: 308 DALNH 312 +ALNH Sbjct: 273 EALNH 277 >3HZT-A nrPDB Length = 467 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 141/305 (46%), Gaps = 59/305 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA-----LREIKILQL 72 +Y+++ K+G G +GEV + + TG + A+K + +K T+ L E+ +L+ Sbjct: 5 RYQRVKKLGSGAYGEVLLCKDKLTGAERAIKII----KKSSVTTTSNSGALLDEVAVLKQ 60 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR--VM 130 L H N++ L E K + YLV + + L ++++ SE+ +M Sbjct: 61 LDHPNIMKLYEFFEDKRN--------YYLVMEV--YRGGELFDEIILRQKFSEVDAAVIM 110 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 + +L+G Y+H++ I+HRD+K N+L+ +RD ++K+ DFGL+ F + + Sbjct: 111 KQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-----GKMKE 165 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 R+ T +Y PE+L + Y D+W G I+ + P G T+Q L + + S Sbjct: 166 RLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFS 223 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 P W V + A L+ +L +P++RI ++ Sbjct: 224 FDPPDWTQVSD----------------------------EAKQLVKLMLTYEPSKRISAE 255 Query: 308 DALNH 312 +ALNH Sbjct: 256 EALNH 260 >2UV2-A nrPDB Length = 325 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 75/234 (32%), Positives = 127/234 (54%), Gaps = 28/234 (11%) Query: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT 62 KQY+ V E +E + ++G G FG+V+KA++++T A K + ++E+E Sbjct: 24 KQYEHVTRDLNPE-DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDY- 81 Query: 63 ALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF- 121 + EI IL H N+V L++ A Y + +++++ +FC G + V+++ Sbjct: 82 -MVEIDILASCDHPNIVKLLD-----AFYY---ENNLWILIEFC---AGGAVDAVMLELE 129 Query: 122 ---TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 T S+I+ V + L+ L Y+H NKI+HRD+KA N+L T DG +KLADFG++ AK Sbjct: 130 RPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS-----AK 184 Query: 179 NSQP-NRYTNRVVTLWYRPPELLLGE----RDYGPPIDLWGAGCIMAEMWTRSP 227 N++ R + + T ++ PE+++ E R Y D+W G + EM P Sbjct: 185 NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEP 238 >4APC-A nrPDB Length = 350 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 86/322 (26%), Positives = 148/322 (45%), Gaps = 39/322 (12%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + KY +L KIG+G+FG+ + + G++ +K++ + + RE+ +L Sbjct: 19 YFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLA 78 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL-SNVLVKFTLSEIKRV 129 +KH N+V E GS+Y+V D+CE DL + + V F +I Sbjct: 79 NMKHPNIVQYRESFEEN--------GSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW 130 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + L ++H KILHRD+K+ N+ +T+DG ++L DFG+AR NS + Sbjct: 131 FVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL----NSTVELARACI 186 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSI 248 T +Y PE + + Y D+W GC++ E+ T + G+ + L +IS GS Sbjct: 187 GTPYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIIS---GS- 241 Query: 249 TPEVWPNVDNYELYEKLELVKGQ-KRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 +P V + Y+ LV KR +DR P +++K + ++ S Sbjct: 242 ----FPPVSLHYSYDLRSLVSQLFKRNPRDR-------PSVNSILEKGFIAKRIEKFLSP 290 Query: 308 DALNHDF-------FWSDPMPS 322 + +F F S P+P+ Sbjct: 291 QLIAEEFCLKTFSKFGSQPIPA 312 >5J5T-A nrPDB Length = 370 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 91/317 (28%), Positives = 156/317 (49%), Gaps = 39/317 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E + +IG GT+G+V+KAR+ TG+ A+K + +E E F + +EI +++ KH N+ Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLE-PGEDFAVVQ-QEIIMMKDCKHPNI 63 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-VKFTLSE--IKRVMQMLLN 135 V Y R + +++ +FC G L ++ V LSE I V + L Sbjct: 64 VAYF-------GSYLR-RDKLWICMEFCG---GGSLQDIYHVTGPLSELQIAYVSRETLQ 112 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQPNRYTNRVVTLW 193 GLYY+H +HRD+K AN+L+T +G +KLADFG++ ++AK + T + Sbjct: 113 GLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKA------FIGTPY 166 Query: 194 YRPPELLLGER--DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + PE+ ER Y DLW G E+ P M L L+++ P+ Sbjct: 167 WMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTK-SNFQPPK 225 Query: 252 V-----WPNVDNYELYEKLELVKG-QKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 + W N ++ + K+ L K +KR ++L ++ P+ + + L ++ +++ Sbjct: 226 LKDKMKWSN--SFHHFVKMALTKNPKKRPTAEKL---LQHPFVTQHLTRSLAIELLDKVN 280 Query: 306 S-DDALNHDFFWSDPMP 321 + D + HDF DP P Sbjct: 281 NPDHSTYHDFDDDDPEP 297 >5ES1-A nrPDB Length = 328 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 114/220 (51%), Gaps = 19/220 (8%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V Y L IG+G F +V ARH TG++VA+K + RE++I++ L H Sbjct: 14 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH 73 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQM 132 N+V L E+ T+ + +YLV ++ AG + + LV + E + + Sbjct: 74 PNIVKLFEVIETEKT--------LYLVMEYAS---AGEVFDYLVSHGRMKEKEARAKFRQ 122 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +++ ++Y H+ I+HRD+KA N+L+ + +K+ADFG + F+L S+ + + + Sbjct: 123 IVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG--SKLDTFCG---SP 177 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 Y PEL G++ GP +D+W G I+ + + S G+ Sbjct: 178 PYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGH 217 >5KZ7-A nrPDB Length = 346 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 109/219 (49%), Gaps = 19/219 (8%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + Y L IG+G F +V ARH TG++VA+K + RE++I+++L H Sbjct: 32 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH 91 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQM 132 N+V L E+ T+ + +YLV ++ G + + LV + E + + Sbjct: 92 PNIVKLFEVIETEKT--------LYLVMEYAS---GGEVFDYLVAHGRMKEKEARAKFRQ 140 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +++ + Y H+ I+HRD+KA N+L+ D +K+ADFG + F+ N+ + Sbjct: 141 IVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG-----NKLDTFCGSP 195 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 Y PEL G++ GP +D+W G I+ + + S G Sbjct: 196 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 234 >6FD3-A nrPDB Length = 300 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 86/321 (26%), Positives = 147/321 (45%), Gaps = 57/321 (17%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D KY + KIGQG G V+ A TGQ+VA+K++ ++ + + I + EI +++ Sbjct: 19 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELI--INEILVMREN 76 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFD----FCEHDLAGLLSNVLVKFTLSE--IK 127 K+ N+VN ++ YLV D E+ G L++V+ + + E I Sbjct: 77 KNPNIVNYLDS---------------YLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 121 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 V + L L ++H N+++HRD+K+ N+L+ DG +KL DFG F + ++ + Sbjct: 122 AVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG----FCAQITPEQSKRST 177 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 V T ++ PE++ + YGP +D+W G + EM P L LI+ + Sbjct: 178 MVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT---N 233 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 TPE+ + +RL A R D +++ L +D +R + Sbjct: 234 GTPEL---------------------QNPERLSAVFR-----DFLNRCLEMDVDRRGSAK 267 Query: 308 DALNHDFFWSDPMPSDLKGML 328 + L H F D S L ++ Sbjct: 268 ELLQHPFLKLDKPLSSLTPLI 288 >2QNJ-A nrPDB Length = 328 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 114/218 (52%), Gaps = 27/218 (12%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL----REIKILQ 71 + Y L IG+G F +V ARH TG++VA+K + +K T+L RE++I++ Sbjct: 11 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKII----DKTQLNPTSLQKLFREVRIMK 66 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKR 128 +L H N+V L E+ T+ + +YL+ ++ G + + LV + E + Sbjct: 67 ILNHPNIVKLFEVIETEKT--------LYLIMEYAS---GGEVFDYLVAHGRMKEKEARS 115 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + +++ + Y H+ +I+HRD+KA N+L+ D +K+ADFG + F++ + Sbjct: 116 KFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVG-----GKLDTF 170 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 + Y PEL G++ GP +D+W G I+ + + S Sbjct: 171 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGS 208 >6C9D-A nrPDB Length = 459 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 114/223 (51%), Gaps = 27/223 (12%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL----REIKILQ 71 + Y IG+G F +V ARH TG++VA+K + +K T+L RE++I++ Sbjct: 20 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKII----DKTQLNPTSLQKLFREVRIMK 75 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKR 128 +L H N+V L E+ T+ + +YLV ++ G + + LV + E + Sbjct: 76 ILNHPNIVKLFEVIETEKT--------LYLVMEYAS---GGEVFDYLVAHGRMKEKEARA 124 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + +++ + Y H+ I+HRD+KA N+L+ D +K+ADFG + F++ N+ Sbjct: 125 KFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-----NKLDEF 179 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 + Y PEL G++ GP +D+W G I+ + + S G Sbjct: 180 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 222 >4FIE-A nrPDB Length = 423 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 87/324 (26%), Positives = 145/324 (44%), Gaps = 53/324 (16%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK M+ K+ E+ I++ Sbjct: 148 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDY 205 Query: 74 KHENVVNLIEICRTKASPYNR--CKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRV 129 +HENVV + YN +++V +F E G L++++ ++E I V Sbjct: 206 QHENVVEM----------YNSYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAV 252 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 +L L +H ++HRD+K+ ++L+T DG +KL+DFG F + + R + V Sbjct: 253 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG----FCAQVSKEVPRRKSLV 308 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T ++ PE L+ YGP +D+W G ++ EM P + +I Sbjct: 309 GTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD------ 361 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 + P + N KV LK + +D+LLV DPAQR + + Sbjct: 362 -NLPPRLKNLH-------------KVSPSLKGF---------LDRLLVRDPAQRATAAEL 398 Query: 310 LNHDFFWSDPMPSDLKGMLSTHLT 333 L H F P+ + ++ + T Sbjct: 399 LKHPFLAKAGPPASIVPLMRQNRT 422 >2Q0N-A nrPDB Length = 301 Score = 98.2 bits (243), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 87/324 (26%), Positives = 145/324 (44%), Gaps = 53/324 (16%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK M+ K+ E+ I++ Sbjct: 26 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDY 83 Query: 74 KHENVVNLIEICRTKASPYNR--CKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRV 129 +HENVV + YN +++V +F E G L++++ ++E I V Sbjct: 84 QHENVVEM----------YNSYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAV 130 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 +L L +H ++HRD+K+ ++L+T DG +KL+DFG F + + R + V Sbjct: 131 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG----FCAQVSKEVPRRKSLV 186 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T ++ PE L+ YGP +D+W G ++ EM P + +I Sbjct: 187 GTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD------ 239 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 + P + N KV LK + +D+LLV DPAQR + + Sbjct: 240 -NLPPRLKNLH-------------KVSPSLKGF---------LDRLLVRDPAQRATAAEL 276 Query: 310 LNHDFFWSDPMPSDLKGMLSTHLT 333 L H F P+ + ++ + T Sbjct: 277 LKHPFLAKAGPPASIVPLMRQNRT 300 >4MD7-E nrPDB Length = 391 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 86/308 (27%), Positives = 151/308 (49%), Gaps = 29/308 (9%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ + K+G+G + EVF+A + +KV +K + +K+ + E L N+ Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE----NLRGGPNI 94 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + L +I + P +R LVF+ + L L + +I+ M +L L Sbjct: 95 ITLADIVK---DPVSRTPA---LVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALD 145 Query: 139 YIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y H I+HRD+K NV+I + L+L D+GLA + + Y RV + +++ P Sbjct: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-----EYNVRVASRYFKGP 200 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 ELL+ + Y +D+W GC++A M + + P G+ QL I+++ G T +++ + Sbjct: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYI 258 Query: 257 DNY--ELYEKLELVKG-QKRKVKDRL----KAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 D Y EL + + G RK +R ++ P ALD +DKLL D R+ + +A Sbjct: 259 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 318 Query: 310 LNHDFFWS 317 + H +F++ Sbjct: 319 MEHPYFYT 326 >3COM-A nrPDB Length = 314 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 111/213 (52%), Gaps = 24/213 (11%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++ L K+G+G++G V+KA H++TGQ VA+K+V +E++ + ++EI I+Q +V Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI----IKEISIMQQCDSPHV 86 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL----VKFTLSEIKRVMQMLL 134 V + S + +++V ++C AG +S+++ T EI ++Q L Sbjct: 87 V------KYYGSYFKNT--DLWIVMEYCG---AGSVSDIIRLRNKTLTEDEIATILQSTL 135 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+H + +HRD+KA N+L+ +G KLADFG+A + ++ R T W Sbjct: 136 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT---DTMAKRNTVIGTPFWM 192 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 P ++ E Y D+W G EM P Sbjct: 193 APE--VIQEIGYNCVADIWSLGITAIEMAEGKP 223 >4JDH-A nrPDB Length = 346 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 87/324 (26%), Positives = 145/324 (44%), Gaps = 53/324 (16%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK M+ K+ E+ I++ Sbjct: 71 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDY 128 Query: 74 KHENVVNLIEICRTKASPYNR--CKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRV 129 +HENVV + YN +++V +F E G L++++ ++E I V Sbjct: 129 QHENVVEM----------YNSYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAV 175 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 +L L +H ++HRD+K+ ++L+T DG +KL+DFG F + + R + V Sbjct: 176 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG----FCAQVSKEVPRRKSLV 231 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T ++ PE L+ YGP +D+W G ++ EM P + +I Sbjct: 232 GTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD------ 284 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 + P + N KV LK + +D+LLV DPAQR + + Sbjct: 285 -NLPPRLKNLH-------------KVSPSLKGF---------LDRLLVRDPAQRATAAEL 321 Query: 310 LNHDFFWSDPMPSDLKGMLSTHLT 333 L H F P+ + ++ + T Sbjct: 322 LKHPFLAKAGPPASIVPLMRQNRT 345 >2HAK-A nrPDB Length = 328 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 113/218 (51%), Gaps = 27/218 (12%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL----REIKILQ 71 + Y IG+G F +V ARH TG++VA+K + +K T+L RE++I++ Sbjct: 14 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKII----DKTQLNPTSLQKLFREVRIMK 69 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKR 128 +L H N+V L E+ T+ + +YLV ++ G + + LV + E + Sbjct: 70 ILNHPNIVKLFEVIETEKT--------LYLVMEYAS---GGEVFDYLVAHGRMKEKEARA 118 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + +++ + Y H+ I+HRD+KA N+L+ D +K+ADFG + F++ N+ Sbjct: 119 KFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-----NKLDTF 173 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 + Y PEL G++ GP +D+W G I+ + + S Sbjct: 174 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGS 211 >6EII-A nrPDB Length = 352 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 86/308 (27%), Positives = 151/308 (49%), Gaps = 29/308 (9%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ + K+G+G + EVF+A + +KV +K + +K+ + E L N+ Sbjct: 62 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILE----NLRGGPNI 117 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + L +I + P +R LVF+ + L L + +I+ M +L L Sbjct: 118 ITLADIVK---DPVSRTPA---LVFEHVNNTDFKQLYQTLTDY---DIRFYMYEILKALD 168 Query: 139 YIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y H I+HRD+K NV+I + L+L D+GLA + + Y RV + +++ P Sbjct: 169 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQ-----EYNVRVASRYFKGP 223 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 ELL+ + Y +D+W GC++A M + + P G+ QL I+++ G T +++ + Sbjct: 224 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG--TEDLYDYI 281 Query: 257 DNY--ELYEKLELVKG-QKRKVKDRL----KAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 D Y EL + + G RK +R ++ P ALD +DKLL D R+ + +A Sbjct: 282 DKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREA 341 Query: 310 LNHDFFWS 317 + H +F++ Sbjct: 342 MEHPYFYT 349 >3Q53-A nrPDB Length = 306 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 113/220 (51%), Gaps = 28/220 (12%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D KY + KIGQG G V+ A TGQ+VA++++ ++ + + I + EI +++ Sbjct: 18 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELI--INEILVMREN 75 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFD----FCEHDLAGLLSNVLVKFTLSE--IK 127 K+ N+VN ++ YLV D E+ G L++V+ + + E I Sbjct: 76 KNPNIVNYLDS---------------YLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 120 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 V + L L ++H N+++HRD+K+ N+L+ DG +KL DFG F + ++ + Sbjct: 121 AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG----FCAQITPEQSKRST 176 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 V T ++ PE++ + YGP +D+W G + EM P Sbjct: 177 MVGTPYWMAPEVVT-RKAYGPKVDIWSLGIMAIEMIEGEP 215 >4XBR-A nrPDB Length = 366 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 87/324 (26%), Positives = 145/324 (44%), Gaps = 53/324 (16%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK M+ K+ E+ I++ Sbjct: 91 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKK--MDLRKQQRRELLFNEVVIMRDY 148 Query: 74 KHENVVNLIEICRTKASPYNR--CKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRV 129 +HENVV + YN +++V +F E G L++++ ++E I V Sbjct: 149 QHENVVEM----------YNSYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAV 195 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 +L L +H ++HRD+K+ ++L+T DG +KL+DFG F + + R + V Sbjct: 196 CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFG----FCAQVSKEVPRRKSLV 251 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T ++ PE L+ YGP +D+W G ++ EM P + +I Sbjct: 252 GTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD------ 304 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 + P + N KV LK + +D+LLV DPAQR + + Sbjct: 305 -NLPPRLKNLH-------------KVSPSLKGF---------LDRLLVRDPAQRATAAEL 341 Query: 310 LNHDFFWSDPMPSDLKGMLSTHLT 333 L H F P+ + ++ + T Sbjct: 342 LKHPFLAKAGPPASIVPLMRQNRT 365 >3LIJ-A nrPDB Length = 494 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 134/300 (44%), Gaps = 52/300 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+++ K+G G +GEV R + T + A+K + + L E+ +L+LL H N+ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 79 VNLIEICRTKASPY--NRC-KGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 + L + K + Y C KG +FD H + KF + +++ +L+ Sbjct: 99 MKLYDFFEDKRNYYLVMECYKGG--ELFDEIIHRM---------KFNEVDAAVIIKQVLS 147 Query: 136 GLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 G+ Y+H++ I+HRD+K N+L+ +D ++K+ DFGL+ F K + R+ T Sbjct: 148 GVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQK-----KMKERLGTA 202 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 +Y PE+L + Y D+W G I+ + P G T+Q L + + + Sbjct: 203 YYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPE 260 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 W NV +G K DLI ++L D +RI + AL H Sbjct: 261 WKNVS-----------EGAK-----------------DLIKQMLQFDSQRRISAQQALEH 292 >3RAW-A nrPDB Length = 381 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/331 (25%), Positives = 150/331 (45%), Gaps = 46/331 (13%) Query: 18 KYEKLAKIGQGTFGEVFKA-RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +YE + +G+GTFG+V + H + +VALK ++ N + + A EI +L+ +K + Sbjct: 52 RYEIVGNLGEGTFGKVVECLDHARGKSQVALK--IIRNVGK-YREAARLEINVLKKIKEK 108 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 + N +C + +N G + + F+ ++ L N + L ++ + L + Sbjct: 109 DKENKF-LCVLMSDWFN-FHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCH 166 Query: 136 GLYYIHRNKILHRDMKAANVLIT-------------------RDGVLKLADFGLARAFSL 176 L ++H N++ H D+K N+L ++ +++ADFG A Sbjct: 167 ALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA----- 221 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQH 236 +T V T YRPPE++L E + P D+W GCI+ E + + Q + + Sbjct: 222 --TFDHEHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENRE 278 Query: 237 QLALISQLCGSITPEVWPNVDNYELYEKLELV----KGQKRKVKDR---LKAY-----VR 284 L ++ ++ G I + + + K LV R VK+ LK+Y + Sbjct: 279 HLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLE 338 Query: 285 DPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 DL+ ++L DPAQRI +AL H FF Sbjct: 339 HVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >1U5R-A nrPDB Length = 348 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 71/248 (28%), Positives = 115/248 (46%), Gaps = 26/248 (10%) Query: 3 KQYDSVECPFCDEVSK-YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 K D E F D+ K + L +IG G+FG V+ AR + + VA+KK+ ++ Sbjct: 39 KDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKW 98 Query: 62 T-ALREIKILQLLKHENVVNLIEICRTKASPYNRC---KGSIYLVFDFCEHDLAGLLSNV 117 ++E++ LQ L+H N + Y C + + +LV ++C + LL Sbjct: 99 QDIIKEVRFLQKLRHPNTIQ-----------YRGCYLREHTAWLVMEYCLGSASDLLEVH 147 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 EI V L GL Y+H + ++HRD+KA N+L++ G++KL DFG A + A Sbjct: 148 KKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA 207 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLG--ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 + V T ++ PE++L E Y +D+W G E+ R P + Sbjct: 208 --------NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAM 259 Query: 236 HQLALISQ 243 L I+Q Sbjct: 260 SALYHIAQ 267 >3F3Z-A nrPDB Length = 277 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 87/298 (29%), Positives = 128/298 (42%), Gaps = 56/298 (18%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKV--LMENEKEGFPITALREIKILQLLKHENVVNLI 82 IG+G++GEV A + T + A KK+ + + F +EI+I++ L H N++ L Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFK----QEIEIMKSLDHPNIIRLY 72 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGLYYI 140 E IYLV + C L V+ K F S+ R+M+ +L+ + Y Sbjct: 73 ETFEDNTD--------IYLVMELCTG--GELFERVVHKRVFRESDAARIMKDVLSAVAYC 122 Query: 141 HRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H+ + HRD+K N L + D LKL DFGLA F K + +V T +Y P Sbjct: 123 HKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMR-----TKVGTPYYVSP 177 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 ++L G YGP D W AG +M + P T+ + I + + + W NV Sbjct: 178 QVLEGL--YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVS 235 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 P A LI +LL P QRI S AL H++F Sbjct: 236 ----------------------------PQAESLIRRLLTKSPKQRITSLQALEHEWF 265 >2GCD-A nrPDB Length = 309 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 114/245 (46%), Gaps = 26/245 (10%) Query: 6 DSVECPFCDEVSK-YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT-A 63 D E F D+ K + L +IG G+FG V+ AR + + VA+KK+ ++ Sbjct: 3 DVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDI 62 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRC---KGSIYLVFDFCEHDLAGLLSNVLVK 120 ++E++ LQ L+H N + Y C + + +LV ++C + LL Sbjct: 63 IKEVRFLQKLRHPNTIQ-----------YRGCYLREHTAWLVMEYCLGSASDLLEVHKKP 111 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 EI V L GL Y+H + ++HRD+KA N+L++ G++KL DFG A + A Sbjct: 112 LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA--- 168 Query: 181 QPNRYTNRVVTLWYRPPELLLG--ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 + V T ++ PE++L E Y +D+W G E+ R P + L Sbjct: 169 -----NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSAL 223 Query: 239 ALISQ 243 I+Q Sbjct: 224 YHIAQ 228 >3TAC-A nrPDB Length = 361 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 92/306 (30%), Positives = 142/306 (46%), Gaps = 56/306 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME--NEKEGFPITAL-REIKILQLLKH 75 YE IG+G F V + +R+TGQ+ A+K V + G L RE I +LKH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEI--KRV 129 ++V L+E + G +Y+VF+F D A L ++ + F SE Sbjct: 88 PHIVELLETYSSD--------GMLYMVFEFM--DGADLCFEIVKRADAGFVYSEAVASHY 137 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ +L L Y H N I+HRD+K VL+ +KL FG+ A L ++ Sbjct: 138 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGV--AIQLGESGLVA--G 193 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 RV T + PE++ E YG P+D+WG G I+ + + G E+ Sbjct: 194 GRVGTPHFMAPEVVKRE-PYGKPVDVWGCGVILFILLSGCLPFYGTKER----------- 241 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 L+E ++KG K K+ R +++ + A DL+ ++L+LDPA+RI Sbjct: 242 --------------LFEG--IIKG-KYKMNPRQWSHISES-AKDLVRRMLMLDPAERITV 283 Query: 307 DDALNH 312 +ALNH Sbjct: 284 YEALNH 289 >4REW-A nrPDB Length = 540 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 77/306 (25%), Positives = 132/306 (43%), Gaps = 68/306 (22%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLLKHENVVNLI 82 +G GTFG+V +H TG KVA+K +L + + REI+ L+L +H +++ L Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVK-ILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 72 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYY 139 ++ T + I++V ++ G L + + K E +R+ Q +L+G+ Y Sbjct: 73 QVISTPSD--------IFMVMEYVS---GGELFDYICKNGRLDEKESRRLFQQILSGVDY 121 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK-----NSQPNRYTNRVVTLWY 194 HR+ ++HRD+K NVL+ K+ADFGL+ S + PN Y Sbjct: 122 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----------Y 171 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI--TPEV 252 PE++ G GP +D+W +G I+ + + + H L ++C I TP+ Sbjct: 172 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD---DDHVPTLFKKICDGIFYTPQY 228 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 +P + L+ +L +DP +R D H Sbjct: 229 L-------------------------------NPSVISLLKHMLQVDPMKRASIKDIREH 257 Query: 313 DFFWSD 318 ++F D Sbjct: 258 EWFKQD 263 >4IAN-A nrPDB Length = 358 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 92/331 (27%), Positives = 146/331 (44%), Gaps = 46/331 (13%) Query: 18 KYEKLAKIGQGTFGEVFKAR-HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +Y GQG F V +AR + + Q+VA+K + E T L+E++ L+ L Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKII---RNNELMQKTGLKELEFLKKLNDA 87 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQMLL 134 + + R Y+ K + LVF+ +L +L V + ++ Q L Sbjct: 88 DPDDKFHCLRLFRHFYH--KQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLF 145 Query: 135 NGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L + R ILH D+K N+L+ +LKL DFG A + N T +V+ + Sbjct: 146 LALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVA------DNDITPYLVSRF 199 Query: 194 YRPPELLLGER-DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 YR PE+++G+ DYG ID+W GC + E++T + G T H L L L G + ++ Sbjct: 200 YRAPEIIIGKSYDYG--IDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKM 257 Query: 253 WPN--VDNYELYEKLELVKGQKRKVKDRLKAYV-------RDPYA--------------- 288 + + L + + KV +R K V +D A Sbjct: 258 IRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKK 317 Query: 289 ----LDLIDKLLVLDPAQRIDSDDALNHDFF 315 DL+D++L+LDPA+RI + AL H F Sbjct: 318 VHQLKDLLDQILMLDPAKRISINQALQHAFI 348 >5XVU-A nrPDB Length = 332 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 83/329 (25%), Positives = 153/329 (46%), Gaps = 48/329 (14%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL 64 YD++E + ++ ++YE + KIG+G + EVF + + A+K + +K+ Sbjct: 20 YDNLELQW-NKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKK----IKR 74 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTL 123 + L N++ L++I + + + L+F++ + D L KFT Sbjct: 75 EIKILQNLNGGPNIIKLLDIVKDPVT------KTPSLIFEYINNIDFKTLYP----KFTD 124 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQP 182 +I+ + +L L Y H I+HRD+K N++I + ++L +GLA + + Sbjct: 125 KDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQ---- 180 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALI 241 Y RV + +Y+ PELL+ + Y +D+W GC++A M + + P G+ QL I Sbjct: 181 -EYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKI 239 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYA------------- 288 +++ G+ + N +L K + L Y R P++ Sbjct: 240 AKVLGTEDLHAYLKKYNIKL----------KPHYLNILGEYERKPWSHFLTQSNIDIAKD 289 Query: 289 --LDLIDKLLVLDPAQRIDSDDALNHDFF 315 +DLIDK+L+ D A+RI +A+ H +F Sbjct: 290 EVIDLIDKMLIYDHAKRIAPKEAMEHPYF 318 >4CFH-A nrPDB Length = 493 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 133/307 (43%), Gaps = 70/307 (22%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLLKHENVVNLI 82 +G GTFG+V +H TG KVA+K +L + + REI+ L+L +H +++ L Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVK-ILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 99 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYY 139 ++ T + I++V ++ G L + + K E +R+ Q +L+G+ Y Sbjct: 100 QVISTPSD--------IFMVMEYVS---GGELFDYICKNGRLDEKESRRLFQQILSGVDY 148 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK-----NSQPNRYTNRVVTLWY 194 HR+ ++HRD+K NVL+ K+ADFGL+ S + PN Y Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----------Y 198 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSI--TPE 251 PE++ G GP +D+W +G I+ + + P + H L ++C I TP+ Sbjct: 199 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF----DDDHVPTLFKKICDGIFYTPQ 254 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 +P + L+ +L +DP +R D Sbjct: 255 YL-------------------------------NPSVISLLKHMLQVDPMKRATIKDIRE 283 Query: 312 HDFFWSD 318 H++F D Sbjct: 284 HEWFKQD 290 >2A1A-B nrPDB Length = 284 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 111/218 (50%), Gaps = 30/218 (13%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++++ IG G FG+VFKA+HR G+ +K+V NEK A RE+K L L H N+ Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVNI 66 Query: 79 VNLIEIC--------RTKASPYNRCKGS-IYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 V+ C T + +R K +++ +FC+ G L + K ++ +V Sbjct: 67 VHY-NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCD---KGTLEQWIEKRRGEKLDKV 122 Query: 130 MQMLL-----NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 + + L G+ YIH K+++RD+K +N+ + +K+ DFGL SL + + R Sbjct: 123 LALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVT--SLKNDGKRTR 180 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 TL Y PE + +DYG +DL+ G I+AE+ Sbjct: 181 SKG---TLRYMSPE-QISSQDYGKEVDLYALGLILAEL 214 >5YKS-A nrPDB Length = 377 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/302 (26%), Positives = 133/302 (44%), Gaps = 50/302 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLLKHENVVNLIE 83 +G+G F V ARH TG+KVA+K V+ + + + L +E++ ++L++H N+V L E Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVK-VIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYE 101 Query: 84 ICRTKASPYNRCK-GSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142 + T+ Y + G +FD+ GL ++ K+ +++ + Y H+ Sbjct: 102 VIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDL--------AKKYFAQIVHAISYCHK 153 Query: 143 NKILHRDMKAANVLI-TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 ++HRD+K NV+ + G++KL DFG + F K + T +L Y PE+LL Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK-----KLTTSCGSLAYSAPEILL 208 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 G+ P +D+W G I+ + P Q + L +I C P Sbjct: 209 GDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD-CKYTVPS---------- 257 Query: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS-DPM 320 V K DLI ++L DP +R ++ NH + DP Sbjct: 258 ------------HVSKECK---------DLITRMLQRDPKRRASLEEIENHPWLQGVDPS 296 Query: 321 PS 322 P+ Sbjct: 297 PA 298 >4LFI-A nrPDB Length = 374 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 92/359 (25%), Positives = 158/359 (44%), Gaps = 69/359 (19%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-------------- 50 Y++ + YE K+G+G + EVF+ + K+ +K + Sbjct: 28 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKI 87 Query: 51 LMENEKEGFPITAL----------REIKILQLLK----------HENVVNLIEICRTKAS 90 L + E P T L ++ +L+ ++ H N+++L +I + Sbjct: 88 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK---D 144 Query: 91 PYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDM 150 P ++ LVF++ ++ +L K T EI+ M LL L Y H I+HRD+ Sbjct: 145 PISKTPA---LVFEYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDV 198 Query: 151 KAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPP 209 K NV+I ++ L+L D+GLA + + Y RV + +++ PELL+ R Y Sbjct: 199 KPHNVMIDHKNKKLRLIDWGLAEFYHVNM-----EYNVRVASRFFKGPELLVDYRMYDYS 253 Query: 210 IDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGS-----------IT-PEVWPNV 256 +DLW G ++A M + R P G + QL I ++ G+ IT P + ++ Sbjct: 254 LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 313 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 D Y + K R + D K + +DLID LL D +R+ + +A+ H +F Sbjct: 314 DQY-------IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >4MVF-A nrPDB Length = 506 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 85/303 (28%), Positives = 141/303 (46%), Gaps = 58/303 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALK---KVLMENEKEGFPITALREIKILQLLK 74 KY K+GQGT+G V+K + T Q A+K K ++N F +EI+I++ L Sbjct: 58 KYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFF-----QEIEIMKKLD 112 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQM 132 H N+V L E IYL+ + C L +++ FT +M+ Sbjct: 113 HPNIVKLYETYEND--------NYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQ 162 Query: 133 LLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + + ++Y+H I+HRD+K N L +D +LK+ DFGL++ + + T + Sbjct: 163 IFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT-----TTKA 217 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T +Y P++L G+ Y D+W +G IM + LCG Sbjct: 218 GTPYYVAPQVLDGK--YDKKCDIWSSGVIMYTL---------------------LCG--Y 252 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 P + + DN E+ +K++ KG+ ++ + D A +LI KLL +P +R ++A Sbjct: 253 PPFYGDTDN-EVLKKVK--KGEFCFYENDWGSISSD--AKNLITKLLTYNPNERCTIEEA 307 Query: 310 LNH 312 LNH Sbjct: 308 LNH 310 >3H4J-B nrPDB Length = 336 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 64/207 (30%), Positives = 105/207 (50%), Gaps = 31/207 (14%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G+FG+V A H KT QKVALK + + +K + REI L+LL+H +++ L + Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQMLLNGLYYI 140 + T I +V ++ G L + +V + T E +R Q ++ + Y Sbjct: 77 VITTPTD--------IVMVIEYA----GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARA-----FSLAKNSQPNRYTNRVVTLWYR 195 HR+KI+HRD+K N+L+ + +K+ADFGL+ F PN Y Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPN----------YA 174 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEM 222 PE++ G+ GP +D+W G ++ M Sbjct: 175 APEVINGKLYAGPEVDVWSCGIVLYVM 201 >4B6L-A nrPDB Length = 281 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 84/312 (26%), Positives = 132/312 (42%), Gaps = 56/312 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLL 73 Y K +G+G F ++A +TG A+K +V +++E L EI++ + L Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKI----LNEIELHRDL 66 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 +H ++V S + +IY+ + C + E++ ++ + Sbjct: 67 QHRHIVRF--------SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQI 118 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TL 192 L+GL Y+H+ ILHRD+K N IT + LK+ DFGLA A+ P + + T Sbjct: 119 LSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLA-----ARLEPPEQRKKTICGTP 173 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE+LL + +GP D+W GC+M + LCGS Sbjct: 174 NYVAPEVLL-RQGHGPEADVWSLGCVMYTL---------------------LCGS----- 206 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 P + +L E +K +V L A + P A L+ +L P R D L H Sbjct: 207 -PPFETADLKETYRCIK----QVHYTLPASLSLP-ARQLLAAILRASPRDRPSIDQILRH 260 Query: 313 DFFWSDPMPSDL 324 DFF P L Sbjct: 261 DFFTKGYTPDRL 272 >4RED-A nrPDB Length = 351 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 76/306 (24%), Positives = 131/306 (42%), Gaps = 68/306 (22%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLLKHENVVNLI 82 +G GTFG+V +H TG VA+K +L + + REI+ L+L +H +++ L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVK-ILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 80 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYY 139 ++ T + I++V ++ G L + + K E +R+ Q +L+G+ Y Sbjct: 81 QVISTPSD--------IFMVMEYVS---GGELFDYICKNGRLDEKESRRLFQQILSGVDY 129 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK-----NSQPNRYTNRVVTLWY 194 HR+ ++HRD+K NVL+ K+ADFGL+ S + PN Y Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----------Y 179 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI--TPEV 252 PE++ G GP +D+W +G I+ + + + H L ++C I TP+ Sbjct: 180 AAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD---DDHVPTLFKKICDGIFYTPQY 236 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 +P + L+ +L +DP +R D H Sbjct: 237 L-------------------------------NPSVISLLKHMLQVDPMKRASIKDIREH 265 Query: 313 DFFWSD 318 ++F D Sbjct: 266 EWFKQD 271 >3UIU-A nrPDB Length = 306 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 66/233 (28%), Positives = 110/233 (47%), Gaps = 47/233 (20%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++++ IG G FG+VFKA+HR G+ +++V NEK A RE+K L L H N+ Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVNI 67 Query: 79 VNLI------------------------EICRTKASPYNRCKGSIYLVFDFCEHDLAGLL 114 V+ E + + +C +++ +FC+ G L Sbjct: 68 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKC---LFIQMEFCD---KGTL 121 Query: 115 SNVLVKFTLSEIKRVMQMLL-----NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG 169 + K ++ +V+ + L G+ YIH K++HRD+K +N+ + +K+ DFG Sbjct: 122 EQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFG 181 Query: 170 LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 L SL + + R TL Y PE + +DYG +DL+ G I+AE+ Sbjct: 182 LVT--SLKNDGKRTRSKG---TLRYMSPE-QISSQDYGKEVDLYALGLILAEL 228 >4YZB-A nrPDB Length = 491 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 80/312 (25%), Positives = 138/312 (44%), Gaps = 51/312 (16%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HE 76 +Y+ +G+G+FGEV + + TGQ+ A+K + K+ L + L H Sbjct: 31 RYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHP 90 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVMQMLL 134 N++ L E + KG YLV + + L ++ + SE+ R+++ +L Sbjct: 91 NIMKLYE--------FFEDKGYFYLVTEV--YTGGELFDEIISRKRFSEVDAARIIRQVL 140 Query: 135 NGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +G+ Y+H+NKI+HRD+K N+L+ +D +++ DFGL+ F K + +++ T Sbjct: 141 SGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTK-----KMKDKIGT 195 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y PE+L G Y D+W G I+ + + P G E L + + + Sbjct: 196 AYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLP 253 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V +P A DLI K+L P RI + DAL Sbjct: 254 QWKK---------------------------VSEP-AKDLIRKMLAYVPTMRISARDALE 285 Query: 312 HDFFWSDPMPSD 323 H++ + +D Sbjct: 286 HEWLKTTDAATD 297 >6QAU-A nrPDB Length = 280 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 134/285 (47%), Gaps = 37/285 (12%) Query: 18 KYEKLAKIGQGTFGEVFKARHR-KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +Y K +G G F VF+ RHR KT +VA+K + +N + I +EIKIL+ L+HE Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS-QILLGKEIKILKELQHE 70 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSE--IKRVMQML 133 N+V L ++ S++LV ++C DLA L K TLSE I+ + + Sbjct: 71 NIVALYDV--------QELPNSVFLVMEYCNGGDLADYLQ---AKGTLSEDTIRVFLHQI 119 Query: 134 LNGLYYIHRNKILHRDMKAANVLITR--------DGV-LKLADFGLARAFSLAKNSQPNR 184 + +H I+HRD+K N+L++ G+ +K+ADFG AR L N Sbjct: 120 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARY--LHSNMMA-- 175 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 + + Y PE+++ + Y DLW G ++ + P Q N+ Q L + + Sbjct: 176 -ADLCGSPMYMAPEVIMSQH-YDAKADLWSIGTVIYQCLVGKPPFQANSPQ-DLRMFYEK 232 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRL--KAYVRDPY 287 S+ P + Y L L +R KDR+ +A+ P+ Sbjct: 233 NRSLMPSIPRETSPYLANLLLGL---LQRNQKDRMDFEAFFSHPF 274 >6E2O-A nrPDB Length = 295 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 66/211 (31%), Positives = 102/211 (48%), Gaps = 25/211 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G+GT+G V+ R ++A+K++ + + P+ EI + + LKH+N+V + Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLH--EEIALHKHLKHKNIVQYLGS 87 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL------VKFTLSEIKRVMQMLLNGLY 138 + F E G LS +L +K I + +L GL Sbjct: 88 FSENG-----------FIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 136 Query: 139 YIHRNKILHRDMKAANVLI-TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+H N+I+HRD+K NVLI T GVLK++DFG ++ + N +T TL Y P Sbjct: 137 YLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLA-GINPCTETFTG---TLQYMAP 192 Query: 198 ELL-LGERDYGPPIDLWGAGCIMAEMWTRSP 227 E++ G R YG D+W GC + EM T P Sbjct: 193 EIIDKGPRGYGKAADIWSLGCTIIEMATGKP 223 >4UZD-A nrPDB Length = 287 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 102/221 (46%), Gaps = 16/221 (7%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G FG V+ AR +++ +ALK + EK G RE++I L+H N++ L Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLY- 74 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 Y +YL+ ++ L KF + L N L Y H Sbjct: 75 -------GYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSK 127 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE 203 +++HRD+K N+L+ G LK+ADFG + ++ +R T TL Y PPE++ G Sbjct: 128 RVIHRDIKPENLLLGSAGELKIADFG------WSVHAPSSRRTTLCGTLDYLPPEMIEG- 180 Query: 204 RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 R + +DLW G + E P + NT Q IS++ Sbjct: 181 RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV 221 >6CQF-A nrPDB Length = 297 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 71/219 (32%), Positives = 110/219 (50%), Gaps = 22/219 (10%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D Y+ L ++G GT+GEVFKAR + +G VALK V ME + + T +EI IL+ Sbjct: 13 DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTC 70 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-VKFTLSE--IKRVM 130 +H N+V Y + +++ +FC AG L ++ V +LSE I V Sbjct: 71 RHANIV-------AYHGSYLWLQ-KLWICMEFCG---AGSLQDIYQVTGSLSELQISYVC 119 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + +L GL Y+H K +HRD+K AN+LI G ++LADFG++ + R + Sbjct: 120 REVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQI----GATLARRLAFIG 175 Query: 191 TLWYRPPEL--LLGERDYGPPIDLWGAGCIMAEMWTRSP 227 T ++ PE+ + + Y D+W G E+ P Sbjct: 176 TPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP 214 >4LG4-A nrPDB Length = 299 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 24/213 (11%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++ L K+G+G++G VFKA H+++GQ VA+K+V +E++ + ++EI I+Q V Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSPYV 68 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL----VKFTLSEIKRVMQMLL 134 V + S + +++V ++C AG +S+++ EI +++ L Sbjct: 69 V------KYYGSYFKNT--DLWIVMEYCG---AGSVSDIIRLRNKTLIEDEIATILKSTL 117 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+H + +HR++KA N+L+ +G KLADFG+A + ++ R T W Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLT---DTMAKRNTVIGTPFWM 174 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 P ++ E Y D+W G EM P Sbjct: 175 APE--VIQEIGYNCVADIWSLGITSIEMAEGKP 205 >6AO5-A nrPDB Length = 362 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 109/213 (51%), Gaps = 24/213 (11%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++ L K+G+G++G VFKA H+++GQ VA+K+V +E++ + ++EI I+Q V Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSPYV 67 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL----VKFTLSEIKRVMQMLL 134 V + S + +++V ++C AG +S+++ EI +++ L Sbjct: 68 V------KYYGSYFKNT--DLWIVMEYCG---AGSVSDIIRLRNKTLIEDEIATILKSTL 116 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+H + +HR++KA N+L+ +G KLADFG+A + ++ R T W Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLT---DTMAKRNTVIGTPFWM 173 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 P ++ E Y D+W G EM P Sbjct: 174 APE--VIQEIGYNCVADIWSLGITSIEMAEGKP 204 >6HXF-B nrPDB Length = 302 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 118/218 (54%), Gaps = 27/218 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E + ++G G FG+V+KA++++TG A K + ++E+E + EI+IL H + Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELE--DYIVEIEILATCDHPYI 78 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF----TLSEIKRVMQMLL 134 V L+ + Y+ G ++++ +FC G + ++++ T +I+ V + +L Sbjct: 79 VKLL------GAYYH--DGKLWIMIEFCP---GGAVDAIMLELDRGLTEPQIQVVCRQML 127 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP-NRYTNRVVTLW 193 L ++H +I+HRD+KA NVL+T +G ++LADFG++ AKN + + + + T + Sbjct: 128 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVS-----AKNLKTLQKRDSFIGTPY 182 Query: 194 YRPPELLLGERDYGPP----IDLWGAGCIMAEMWTRSP 227 + PE+++ E P D+W G + EM P Sbjct: 183 WMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEP 220 >3D2K-A nrPDB Length = 272 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 104/221 (47%), Gaps = 16/221 (7%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVL-MENEKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G FG V+ AR R++ +ALK + + EK G RE++I L+H N++ L Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLY- 78 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 Y +YL+ ++ L +F + L N L Y H Sbjct: 79 -------GYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSK 131 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE 203 +++HRD+K N+L+ +G LK+ADFG + ++ +R T TL Y PPE++ G Sbjct: 132 RVIHRDIKPENLLLGSNGELKIADFG------WSVHAPSSRRTTLCGTLDYLPPEMIEG- 184 Query: 204 RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 R + +DLW G + E P + +T Q IS++ Sbjct: 185 RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV 225 >1ZXE-A nrPDB Length = 303 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/258 (29%), Positives = 126/258 (48%), Gaps = 25/258 (9%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S +E++A +GQG FG+V KAR+ + A+KK+ EK T L E+ +L L H+ Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQ 62 Query: 77 NVVNLIEIC---RTKASPYN--RCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 VV R P + K ++++ ++CE+ L L+ + + E R+ Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLF 122 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA----RAFSLAK-NSQ---- 181 + +L L YIH I+HR++K N+ I +K+ DFGLA R+ + K +SQ Sbjct: 123 RQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 182 -PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 + T+ + T Y E+L G Y ID++ G I EM I +T ++ + Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM-----IYPFSTGMERVNI 237 Query: 241 ISQLCGSITPEVWPNVDN 258 + +L S++ E P+ D+ Sbjct: 238 LKKL-RSVSIEFPPDFDD 254 >4JXF-A nrPDB Length = 266 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 77/294 (26%), Positives = 132/294 (44%), Gaps = 51/294 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G+F V++A TG +VA+K + + K G E+KI LKH +++ L Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILEL-- 72 Query: 84 ICRTKASPYNRCKGS--IYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 YN + S +YLV + C + ++ L N + F+ +E + M ++ G+ Y+ Sbjct: 73 --------YNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYL 124 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 H + ILHRD+ +N+L+TR+ +K+ADFGLA + ++ T Y PE + Sbjct: 125 HSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPH----EKHYTLCGTPNYISPE-I 179 Query: 201 LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYE 260 +G D+W GC+ + P +T ++ L + + +YE Sbjct: 180 ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV-------------LADYE 226 Query: 261 LYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 + L + A DLI +LL +PA R+ L+H F Sbjct: 227 MPSFLSI-------------------EAKDLIHQLLRRNPADRLSLSSVLDHPF 261 >2F57-A nrPDB Length = 317 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 79/299 (26%), Positives = 136/299 (45%), Gaps = 59/299 (19%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG+G+ G V A + TG++VA+KK M+ K+ E+ I++ H+NVV++ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKK--MDLRKQQRRELLFNEVVIMRDYHHDNVVDMY- 108 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLNGLYYIH 141 S Y +++V +F E G L++++ ++E I V +L L Y+H Sbjct: 109 ------SSY-LVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIATVCLSVLRALSYLH 158 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 ++HRD+K+ ++L+T DG +KL+DFG S P R + V T ++ PE ++ Sbjct: 159 NQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVS---KEVPKR-KSLVGTPYWMAPE-VI 213 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 YG +D+W G ++ EM P P + L Sbjct: 214 SRLPYGTEVDIWSLGIMVIEMIDGEP--------------------------PYFNEPPL 247 Query: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALD-----LIDKLLVLDPAQRIDSDDALNHDFF 315 R+++D L V+D + + +D +LV +P+QR + + L H F Sbjct: 248 Q--------AMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL 298 >2WO6-A nrPDB Length = 382 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 88/337 (26%), Positives = 144/337 (42%), Gaps = 50/337 (14%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +YE + IG+G+FG+V KA R + VA+K + K+ F A E+++L+L+ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII---KNKKAFLNQAQIEVRLLELMNK 109 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQMLL 134 + I K + + + LVF+ ++L LL N + +L+ ++ Q + Sbjct: 110 HDTEMKYYIVHLKR--HFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 135 NGLYYIHRNK--ILHRDMKAANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L ++ + I+H D+K N+L+ + +K+ DFG + R + Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG-------QRIYQYIQ 220 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + +YR PE+LLG Y ID+W GCI+ EM T P+ G E Q+ I ++ G Sbjct: 221 SRFYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 279 Query: 251 EVWPNVDNY-ELYEKLELVKGQKRKVKDRLKAY--------------------------- 282 + + +EKL +K KD + Y Sbjct: 280 HILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGES 339 Query: 283 ---VRDPYAL-DLIDKLLVLDPAQRIDSDDALNHDFF 315 V D DLI ++L DP RI AL H FF Sbjct: 340 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF 376 >2BRG-A nrPDB Length = 297 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 31/217 (14%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V ++ + +G+G +GEV A +R T + VA+K V M+ + P +EI I ++L H Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 76 ENVVNLIEICRTKASPYNRCKGSI-YLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQM 132 ENVV +R +G+I YL ++C L + + E +R Sbjct: 65 ENVVKFYG---------HRREGNIQYLFLEYCSG--GELFDRIEPDIGMPEPDAQRFFHQ 113 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR---- 188 L+ G+ Y+H I HRD+K N+L+ LK++DFGLA F RY NR Sbjct: 114 LMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVF---------RYNNRERLL 164 Query: 189 ---VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 TL Y PELL + P+D+W G ++ M Sbjct: 165 NKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAM 201 >2VN9-A nrPDB Length = 301 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 80/302 (26%), Positives = 134/302 (44%), Gaps = 52/302 (17%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y+ ++G+G F V + TGQ+ A K + + RE +I +LLKH N Sbjct: 5 EYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPN 64 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLN 135 +V L + + G YLVFD L +++ + ++ ++ +Q +L Sbjct: 65 IVRLHDSISEE--------GFHYLVFDLVTG--GELFEDIVAREYYSEADASHCIQQILE 114 Query: 136 GLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + + H N I+HRD+K N+L+ ++ +KLADFGLA + + T Sbjct: 115 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA----IEVQGDQQAWFGFAGTP 170 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL--ALISQLCGSITP 250 Y PE+L + YG P+D+W G I+ + P + +QH+L + + +P Sbjct: 171 GYLSPEVLRKD-PYGKPVDMWACGVILYILLVGYPPFW-DEDQHRLYQQIKAGAYDFPSP 228 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E W V P A DLI+K+L ++PA+RI + +AL Sbjct: 229 E-WDTV----------------------------TPEAKDLINKMLTINPAKRITASEAL 259 Query: 311 NH 312 H Sbjct: 260 KH 261 >3Q5I-A nrPDB Length = 504 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 70/268 (26%), Positives = 120/268 (44%), Gaps = 39/268 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG-----------FPITALREI 67 Y K+ K+G G +GEV + + + A+K + +G F EI Sbjct: 38 YFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEI 97 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLS 124 +L+ L H N++ L ++ K YLV +F E G L ++ KF Sbjct: 98 SLLKSLDHPNIIKLFDVFEDKKY--------FYLVTEFYE---GGELFEQIINRHKFDEC 146 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL---KLADFGLARAFSLAKNSQ 181 + +M+ +L+G+ Y+H++ I+HRD+K N+L+ L K+ DFGL+ F S+ Sbjct: 147 DAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFF-----SK 201 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 + +R+ T +Y PE+L ++ Y D+W G IM + P G +Q + + Sbjct: 202 DYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKV 259 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVK 269 + W N+ + E EL+K Sbjct: 260 EKGKYYFDFNDWKNISD----EAKELIK 283 >4D28-A nrPDB Length = 446 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 103/208 (49%), Gaps = 19/208 (9%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLLK 74 V KYE IG+GTF +V AR+ TG VA+K + + + + REI I+++++ Sbjct: 8 VGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVR 67 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVMQ 131 H N+V L E+ +K+ IY+V +F G L + +V + E ++ Q Sbjct: 68 HPNIVRLYEVLASKSK--------IYIVLEFV---TGGELFDRIVHKGRLKEDESRKYFQ 116 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L++ + + H + HRD+K N+L+ +G LK++DFGL S + T Sbjct: 117 QLVDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGL----SALPQEGVELLNDTCGT 172 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIM 219 Y PE+L G+ G D+W G I+ Sbjct: 173 PNYVAPEVLSGQGYDGSAADIWSCGVIL 200 >6FYV-A nrPDB Length = 337 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 79/337 (23%), Positives = 145/337 (43%), Gaps = 56/337 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKA-RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++YE + +G+G FG+V + H G VA+K V + A EI++L+ L Sbjct: 14 ARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV---KNVGRYREAARSEIQVLEHLNS 70 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS------NVLVKFTLSEIKRV 129 + N + C ++ G + +VF+ L GL + N + F + I+++ Sbjct: 71 TDP-NSVFRCVQMLEWFDH-HGHVCIVFE-----LLGLSTYDFIKENSFLPFQIDHIRQM 123 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-------------------LKLADFGL 170 + + ++H NK+ H D+K N+L + +K+ DFG Sbjct: 124 AYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGS 183 Query: 171 ARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQ 230 A ++ V T YR PE++L + P D+W GCI+ E + + Q Sbjct: 184 A-------TYDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQ 235 Query: 231 GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL-----------VKGQKRKVKDRL 279 + + LA++ ++ G I + + + +L V+ + + +K+ + Sbjct: 236 THDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFM 295 Query: 280 KAYVRDPYAL-DLIDKLLVLDPAQRIDSDDALNHDFF 315 + + L DL+ ++L DP QRI D+AL H FF Sbjct: 296 LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >4CZT-A nrPDB Length = 464 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 104/208 (50%), Gaps = 17/208 (8%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLLK 74 V KYE +G+GTF +V AR+ + G VA+K + E + I + REI ++L+K Sbjct: 10 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 69 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLVKFTLSEIKRVMQM 132 H NV+ + E+ +K IY V +F + SN +K E ++ Q Sbjct: 70 HPNVIRMFEVMASKTK--------IYFVLEFVTGGELFDKISSNGRLK--EDEARKYFQQ 119 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-T 191 L+N + Y H + HRD+K N+L+ +G LK++DFGL+ +L + + + + T Sbjct: 120 LINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGT 176 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIM 219 Y PE++ + G DLW G I+ Sbjct: 177 PNYVAPEVINNKGYDGAKADLWSCGVIL 204 >4B8L-A nrPDB Length = 286 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/220 (31%), Positives = 107/220 (48%), Gaps = 26/220 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G FG V+ AR ++ +ALK + EKEG REI+I L+H N++ + Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYN 82 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR---VMQMLLNGLYYI 140 Y + IYL+ +F G L L K + +R M+ L + L+Y Sbjct: 83 --------YFHDRKRIYLMLEFAPR---GELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLA-RAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 H K++HRD+K N+L+ G LK+ADFG + A SL + + TL Y PPE+ Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTM-------CGTLDYLPPEM 184 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQ--GNTEQHQ 237 + G + + +DLW AG + E P +TE H+ Sbjct: 185 IEG-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHR 223 >5D7A-A nrPDB Length = 308 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 111/223 (49%), Gaps = 20/223 (8%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D +E + +G GT+G+V+K RH KTGQ A+K + + ++E +EI +L+ Sbjct: 14 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE---EIKQEINMLKKY 70 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF---TLSE--IKR 128 H + K +P ++LV +FC AG +++++ TL E I Sbjct: 71 SHHRNIATYYGAFIKKNPPG-MDDQLWLVMEFCG---AGSVTDLIKNTKGNTLKEEWIAY 126 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + + +L GL ++H++K++HRD+K NVL+T + +KL DFG++ + R Sbjct: 127 ICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGRRNTF 182 Query: 189 VVTLWYRPPELLLGERD----YGPPIDLWGAGCIMAEMWTRSP 227 + T ++ PE++ + + Y DLW G EM +P Sbjct: 183 IGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAP 225 >4WNO-A nrPDB Length = 287 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 74/238 (31%), Positives = 113/238 (47%), Gaps = 35/238 (14%) Query: 14 DEVSKYEKLAK--IGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKIL 70 + V K+E K IG G F VFK RHR +VA+K + +N + + +EIKIL Sbjct: 13 ETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG-KEIKIL 71 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE--IK 127 + LKHEN+V L + + S+YLV ++C DLA L + TLSE I+ Sbjct: 72 KELKHENIVALYD--------FQEMANSVYLVMEYCNGGDLADYLHAMR---TLSEDTIR 120 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV---------LKLADFGLARAFSLAK 178 +Q + + +H I+HRD+K N+L++ +K+ADFG AR Sbjct: 121 LFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL---- 176 Query: 179 NSQPNRYTNRVV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 Q N + + Y PE+++ + Y DLW G I+ + T Q ++ Q Sbjct: 177 --QSNMMAATLCGSPMYMAPEVIMSQH-YDGKADLWSIGTIVYQCLTGKAPFQASSPQ 231 >5WAX-A nrPDB Length = 310 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 92/351 (26%), Positives = 153/351 (43%), Gaps = 55/351 (15%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 S++ P + +YE + IG G FG R+R GQ VA+K + E RE Sbjct: 1 SMDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI---ERGEKIDENVQRE 57 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE 125 I + L+H N++ E+ T + +V ++ +L + N +F+ E Sbjct: 58 IINHRSLRHPNIIRFKEVILTPTH--------LAIVMEYASGGELFERICNA-GRFSEDE 108 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQ 181 + Q L++G+ Y H ++ HRD+K N L+ DG LK+ DFG +++ L +SQ Sbjct: 109 ARFFFQQLISGVSYCHSMQVCHRDLKLENTLL--DGSTAPRLKICDFGYSKSSVL--HSQ 164 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 P + V T Y PE+LL + G D+W G + M Sbjct: 165 PK---STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM------------------- 202 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDP 300 L G+ E N+ + ++ + G + + D YV P DLI ++ V +P Sbjct: 203 --LVGAYPFEDPDEPKNFR--KTIQRILGVQYSIPD----YVHISPECQDLISRIFVANP 254 Query: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQ 351 A RI + NH +F + +P+DL M + ++ +E P + +I Q Sbjct: 255 ATRITIPEIRNHPWFLKN-LPADL--MDDSTMSKQYEEPEQPMQSMDEIMQ 302 >4KS7-A nrPDB Length = 292 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 137/304 (45%), Gaps = 49/304 (16%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 KIG+G+ G V AR + +G++VA+K +M+ K+ E+ I++ +H NVV + Sbjct: 29 VKIGEGSTGIVCLAREKHSGRQVAVK--MMDLRKQQRRELLFNEVVIMRDYQHFNVVEMY 86 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLNGLYYI 140 + ++++ +F + G L++++ + L+E I V + +L L Y+ Sbjct: 87 KSYLVGEE--------LWVLMEFLQ---GGALTDIVSQVRLNEEQIATVCEAVLQALAYL 135 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 H ++HRD+K+ ++L+T DG +KL+DFG S P R + V T ++ PE + Sbjct: 136 HAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQIS---KDVPKR-KSLVGTPYWMAPE-V 190 Query: 201 LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYE 260 + Y +D+W G ++ EM P P + Sbjct: 191 ISRSLYATEVDIWSLGIMVIEMVDGEP--------------------------PYFSDSP 224 Query: 261 LYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPM 320 + L K+K+ K P D ++++LV DP +R + + L+H F + Sbjct: 225 VQAMKRLRDSPPPKLKNSHKV---SPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGL 281 Query: 321 PSDL 324 P L Sbjct: 282 PECL 285 >2WQN-A nrPDB Length = 310 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/214 (31%), Positives = 103/214 (48%), Gaps = 38/214 (17%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKV----LMENEKEGFPITALREIKILQLLKHENVV 79 KIG+G F EV++A G VALKKV LM+ + ++EI +L+ L H NV+ Sbjct: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARA---DCIKEIDLLKQLNHPNVI 95 Query: 80 ----NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE-------IKR 128 + IE + +V + + AG LS ++ F + + + Sbjct: 96 KYYASFIE------------DNELNIVLELAD---AGDLSRMIKHFKKQKRLIPERTVWK 140 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 L + L ++H +++HRD+K ANV IT GV+KL D GL R FS S+ + Sbjct: 141 YFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS----SKTTAAHSL 196 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 V T +Y PE + E Y D+W GC++ EM Sbjct: 197 VGTPYYMSPE-RIHENGYNFKSDIWSLGCLLYEM 229 >3GUB-A nrPDB Length = 295 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 86/325 (26%), Positives = 138/325 (42%), Gaps = 64/325 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVA---LKKVLMENEKEGFPITAL-REIKILQLLK 74 Y+ ++G G F V K R + TG + A +KK ++ + G + RE+ IL+ ++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQ 131 H NV+ L E+ K V E G L + L + T E ++ Sbjct: 73 HPNVITLHEVYENKTD-----------VILIGELVAGGELFDFLAEKESLTEEEATEFLK 121 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTN 187 +LNG+YY+H +I H D+K N+++ V +K+ DFGLA N + N Sbjct: 122 QILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG-----NEFKN 176 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T + PE++ E G D+W G I + + + G+T+Q LA +S + Sbjct: 177 IFGTPEFVAPEIVNYE-PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAV--- 232 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL--DLIDKLLVLDPAQRID 305 NYE ++ Y + AL D I +LLV DP +R+ Sbjct: 233 ----------NYEFEDE-----------------YFSNTSALAKDFIRRLLVKDPKKRMT 265 Query: 306 SDDALNHDFFWSDPMPSDLKGMLST 330 D+L H + P D + LS+ Sbjct: 266 IQDSLQHPWI----KPKDTQQALSS 286 >2Y7J-A nrPDB Length = 365 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 63/315 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIK--------- 68 KY+ IG+G V + HR TG + A+K +ME E L E++ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVK--IMEVTAERLSPEQLEEVREATRRETHI 152 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--I 126 + Q+ H +++ LI+ + + ++LVFD L + K LSE Sbjct: 153 LRQVAGHPHIITLIDSYESSSF--------MFLVFDLMRK--GELFDYLTEKVALSEKET 202 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + +M+ LL + ++H N I+HRD+K N+L+ + ++L+DFG + +P Sbjct: 203 RSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL------EPGEKL 256 Query: 187 NRVV-TLWYRPPELLLGERD-----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 + T Y PE+L D YG +DLW G I+ + SP + L + Sbjct: 257 RELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRM 316 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 I + + W + R DLI +LL +DP Sbjct: 317 IMEGQYQFSSPEWDD----------------------------RSSTVKDLISRLLQVDP 348 Query: 301 AQRIDSDDALNHDFF 315 R+ ++ AL H FF Sbjct: 349 EARLTAEQALQHPFF 363 >5EZV-A nrPDB Length = 560 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 134/310 (43%), Gaps = 65/310 (20%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL--REIKILQLLKHENVVNLI 82 +G GTFG+V H+ TG KVA+K +L + + REI+ L+L +H +++ L Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 94 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNGLYY 139 ++ T ++V ++ G L + + K E +R+ Q +L+ + Y Sbjct: 95 QVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLFQQILSAVDY 143 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK-----NSQPNRYTNRVVTLWY 194 HR+ ++HRD+K NVL+ K+ADFGL+ S + PN Y Sbjct: 144 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----------Y 193 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ G GP +D+W G I L + LCG++ Sbjct: 194 AAPEVISGRLYAGPEVDIWSCGVI---------------------LYALLCGTLP----- 227 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 D+ + + ++G + + L V L+ +L +DP +R D H++ Sbjct: 228 -FDDEHVPTLFKKIRGGVFYIPEYLNRSV-----ATLLMHMLQVDPLKRATIKDIREHEW 281 Query: 315 FWSDPMPSDL 324 F D +PS L Sbjct: 282 FKQD-LPSYL 290 >4CQG-A nrPDB Length = 331 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 81/310 (26%), Positives = 145/310 (46%), Gaps = 53/310 (17%) Query: 14 DEVSKYEKLAK-IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQ 71 DE+ KY +L + IG G F +V A H TG+ VA+K +M+ G + ++ EI L+ Sbjct: 5 DELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIK--IMDKNALGSDLPRVKTEIDALK 62 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKR 128 L+H+++ L + TK I++V ++C G L + ++ + + E + Sbjct: 63 SLRHQHICQLYHVLETK--------NKIFMVLEYCP---GGELFDYIISQDRLSEEETRV 111 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 V + +L+ + Y+H HRD+K N+L + LKL DFGL + K ++ Sbjct: 112 VFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLC---AKPKGNKDYHLQEC 168 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 +L Y PEL+ G+ G D+W G ++ + +CG + Sbjct: 169 CGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL---------------------MCGFL 207 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 + + + LY+K +++G K +V L P ++ L+ ++L +DP +RI + Sbjct: 208 P---FDDDNVMALYKK--IMRG-KYEVPKWLS-----PSSILLLQQMLQVDPKKRISMRN 256 Query: 309 ALNHDFFWSD 318 LNH + D Sbjct: 257 LLNHPWVMQD 266 >4CFF-A nrPDB Length = 571 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 79/310 (25%), Positives = 134/310 (43%), Gaps = 65/310 (20%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL--REIKILQLLKHENVVNLI 82 +G GTFG+V H+ TG KVA+K +L + + REI+ L+L +H +++ L Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 99 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNGLYY 139 ++ T ++V ++ G L + + K E +R+ Q +L+ + Y Sbjct: 100 QVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLFQQILSAVDY 148 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK-----NSQPNRYTNRVVTLWY 194 HR+ ++HRD+K NVL+ K+ADFGL+ S + PN Y Sbjct: 149 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN----------Y 198 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ G GP +D+W G I L + LCG++ Sbjct: 199 AAPEVISGRLYAGPEVDIWSCGVI---------------------LYALLCGTLP----- 232 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 D+ + + ++G + + L V L+ +L +DP +R D H++ Sbjct: 233 -FDDEHVPTLFKKIRGGVFYIPEYLNRSV-----ATLLMHMLQVDPLKRATIKDIREHEW 286 Query: 315 FWSDPMPSDL 324 F D +PS L Sbjct: 287 FKQD-LPSYL 295 >3IS5-A nrPDB Length = 285 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 76/300 (25%), Positives = 133/300 (44%), Gaps = 54/300 (18%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLI 82 K+G G FG+V R +G + +K + ++ P+ + EI++L+ L H N++ + Sbjct: 29 KLGSGAFGDVHLVEERSSGLERVIKTI--NKDRSQVPMEQIEAEIEVLKSLDHPNIIKIF 86 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLVKFTLSE--IKRVMQMLLNGLY 138 E+ Y+ ++Y+V + CE L ++S LSE + +M+ ++N L Sbjct: 87 EVFED----YH----NMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALA 138 Query: 139 YIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Y H ++H+D+K N+L + +K+ DFGLA F ++S TN T Y Sbjct: 139 YFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-----TNAAGTALYM 193 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE+ +RD D+W AG +M + T G + L + Q P Sbjct: 194 APEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTS----LEEVQQKATYKEP----- 242 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 NY ++ P A+DL+ ++L DP +R + L+H++F Sbjct: 243 --NY------------------AVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >2XNP-A nrPDB Length = 279 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 103/221 (46%), Gaps = 26/221 (11%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 YE L IG G++G K R + G+ + K++ + E + E+ +L+ LKH N+ Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT-----LSE--IKRVMQ 131 V R +R ++Y+V ++CE G L++V+ K T L E + RVM Sbjct: 68 V------RYYDRIIDRTNTTLYIVMEYCE---GGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 132 MLLNGLYYIHR-----NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 L L HR + +LHRD+K ANV + +KL DFGLAR N + Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL----NHDTSFAK 174 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 V T +Y PE + Y D+W GC++ E+ P Sbjct: 175 TFVGTPYYMSPE-QMNRMSYNEKSDIWSLGCLLYELCALMP 214 >5UNP-A nrPDB Length = 369 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 79/341 (23%), Positives = 148/341 (43%), Gaps = 66/341 (19%) Query: 18 KYEKLAKIGQGTFGEVFKA-RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +YE ++ +G+GTFG V + HR+ G +VALK + E + A EI +L+ + + Sbjct: 35 RYEIVSTLGEGTFGRVVQCVDHRRGGARVALKII---KNVEKYKEAARLEINVLEKINEK 91 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-----DLAGLLS------NVLVKFTLSE 125 + N N C ++ FD+ H +L GL + N + + + + Sbjct: 92 DPDNK-----------NLCV-QMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQ 139 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-------------------RDGVLKLA 166 ++ + L + ++H NK+ H D+K N+L + +++ Sbjct: 140 VRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVV 199 Query: 167 DFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 DFG A ++ V T YR PE++L E + P D+W GCI+ E + Sbjct: 200 DFGSA-------TFDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGF 251 Query: 227 PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL-----------VKGQKRKV 275 + Q + + LA++ ++ G I + + + + L V+ + + Sbjct: 252 TLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPL 311 Query: 276 KDRLKAYVRDPYAL-DLIDKLLVLDPAQRIDSDDALNHDFF 315 + L + + + L DLI+ +L +PA+R+ +AL H FF Sbjct: 312 RRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >2YCR-A nrPDB Length = 323 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 88/322 (27%), Positives = 137/322 (42%), Gaps = 64/322 (19%) Query: 25 IGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFP-ITALREIKILQLLKHENV 78 +G G GEV A RKT +KVA+K K + + +E P + EI+IL+ L H + Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM---QMLLN 135 + + A Y Y+V + E L V+ L E + QMLL Sbjct: 78 IKIKNF--FDAEDY-------YIVLELMEG--GELFDKVVGNKRLKEATCKLYFYQMLL- 125 Query: 136 GLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + Y+H N I+HRD+K NVL++ D ++K+ DFG ++ + + T Sbjct: 126 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-----ETSLMRTLCGTP 180 Query: 193 WYRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG---S 247 Y PE+L+ G Y +D W G I+ + P + + Q++L Q+ + Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVSLKDQITSGKYN 238 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 PEVW V ALDL+ KLLV+DP R ++ Sbjct: 239 FIPEVWAEVSEK----------------------------ALDLVKKLLVVDPKARFTTE 270 Query: 308 DALNHDFFWSDPMPSDLKGMLS 329 +AL H + + M + +LS Sbjct: 271 EALRHPWLQDEDMKRKFQDLLS 292 >5XZW-A nrPDB Length = 471 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 81/306 (26%), Positives = 130/306 (42%), Gaps = 64/306 (20%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG F V KA R TG+ A+K ++ + + G RE+++LQ L H +V L Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVK-IISKRKVIGNMDGVTRELEVLQKLNHPRIVRL--- 259 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI--KRVMQMLLNGLYYIHR 142 + S Y+V +F L+ V + E + + + +L + YIH Sbjct: 260 -----KGFYEDTESYYMVMEFVSG--GDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 312 Query: 143 NKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVV--TLWYRPPE 198 I HRD+K N+LI +D ++K+ DFGLA+ Q N + TL Y PE Sbjct: 313 MGISHRDLKPDNILIEQDDPVLVKITDFGLAKV-------QGNGSFMKTFCGTLAYVAPE 365 Query: 199 LLLGE------------RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 ++ G+ +Y +D+W GC++ + T G+T+ Sbjct: 366 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQD----------- 414 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 +LY+++ G+ + LK + A D ID LL +DP R + Sbjct: 415 -------------QLYKQI----GRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTA 457 Query: 307 DDALNH 312 ALNH Sbjct: 458 AKALNH 463 >5X8I-B nrPDB Length = 346 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 87/339 (25%), Positives = 145/339 (42%), Gaps = 60/339 (17%) Query: 17 SKYEKLAKIGQGTFGEVFKA-RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++YE + +G+G FG+V + H+ G+ VA+K V + + A EI Q+L+H Sbjct: 13 ARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIV---KNVDRYCEAARSEI---QVLEH 66 Query: 76 ENVVNLIEICR-TKASPYNRCKGSIYLVFDFCEHDLAGLLS------NVLVKFTLSEIKR 128 N + R + + G I +VF+ L GL + N + F L I++ Sbjct: 67 LNTTDPNSTFRCVQMLEWFEHHGHICIVFE-----LLGLSTYDFIKENGFLPFRLDHIRK 121 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVL-------------ITRDGV------LKLADFG 169 + + + ++H NK+ H D+K N+L I RD +K+ DFG Sbjct: 122 MAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG 181 Query: 170 LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIM 229 A ++ V T YR PE++L + P D+W GCI+ E + + Sbjct: 182 SA-------TYDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVF 233 Query: 230 QGNTEQHQLALISQLCGSITPEV--------WPNVDNYELYEKLELVKGQKRKVKDRLKA 281 + + LA++ ++ G + + + + D + E + R K LK Sbjct: 234 PTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKP-LKE 292 Query: 282 Y-----VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + V DLI K+L DPA+RI +AL H FF Sbjct: 293 FMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >2VZ6-A nrPDB Length = 313 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/303 (25%), Positives = 133/303 (43%), Gaps = 52/303 (17%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S Y+ ++G+G F V + GQ+ A K + + RE +I +LLKH Sbjct: 22 SMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 81 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLL 134 N+V L + + G YL+FD L +++ + ++ ++ +Q +L Sbjct: 82 NIVRLHDSISEE--------GHHYLIFDLVTG--GELFEDIVAREYYSEADASHCIQQIL 131 Query: 135 NGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + + H+ ++HRD+K N+L+ + +KLADFGLA + + + T Sbjct: 132 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----IEVEGEQQAWFGFAGT 187 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL--ALISQLCGSIT 249 Y PE+L + YG P+DLW G I+ + P + +QH+L + + + Sbjct: 188 PGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFW-DEDQHRLYQQIKAGAYDFPS 245 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 PE W V P A DLI+K+L ++P++RI + +A Sbjct: 246 PE-WDTV----------------------------TPEAKDLINKMLTINPSKRITAAEA 276 Query: 310 LNH 312 L H Sbjct: 277 LKH 279 >2YZA-A nrPDB Length = 276 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/310 (25%), Positives = 136/310 (43%), Gaps = 65/310 (20%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL--REIKILQLLKHENVVNLI 82 +G GTFG+V H+ TG KVA+K +L + + REI+ L+L +H +++ L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVK-ILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 77 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNGLYY 139 ++ T ++V ++ G L + + K E +R+ Q +L+ + Y Sbjct: 78 QVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLFQQILSAVDY 126 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS---LAKNS--QPNRYTNRVVTLWY 194 HR+ ++HRD+K NVL+ K+ADFGL+ S ++S PN Y Sbjct: 127 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPN----------Y 176 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ G GP +D+W G I L + LCG++ Sbjct: 177 AAPEVISGRLYAGPEVDIWSCGVI---------------------LYALLCGTLP----- 210 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 D+ + + ++G + + L V L+ +L +DP +R D H++ Sbjct: 211 -FDDEHVPTLFKKIRGGVFYIPEYLNRSVAT-----LLMHMLQVDPLKRATIKDIREHEW 264 Query: 315 FWSDPMPSDL 324 F D +PS L Sbjct: 265 FKQD-LPSYL 273 >3I6U-A nrPDB Length = 419 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 87/321 (27%), Positives = 138/321 (42%), Gaps = 62/321 (19%) Query: 25 IGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFP-ITALREIKILQLLKHENV 78 +G G GEV A RKT +KVA++ K + + +E P + EI+IL+ L H + Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 202 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLNG 136 + + A Y Y+V + E L V+ L E K +L Sbjct: 203 IKIKNF--FDAEDY-------YIVLELMEG--GELFDKVVGNKRLKEATCKLYFYQMLLA 251 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y+H N I+HRD+K NVL++ D ++K+ DFG ++ + + T Sbjct: 252 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILG-----ETSLMRTLCGTPT 306 Query: 194 YRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG---SI 248 Y PE+L+ G Y +D W G I+ + P + + Q++L Q+ + Sbjct: 307 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF--SEHRTQVSLKDQITSGKYNF 364 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 PEVW E+ EK ALDL+ KLLV+DP R +++ Sbjct: 365 IPEVWA-----EVSEK-----------------------ALDLVKKLLVVDPKARFTTEE 396 Query: 309 ALNHDFFWSDPMPSDLKGMLS 329 AL H + + M + +LS Sbjct: 397 ALRHPWLQDEDMKRKFQDLLS 417 >2V7O-A nrPDB Length = 336 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/314 (25%), Positives = 138/314 (43%), Gaps = 67/314 (21%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 F D+ +E+L G+G F V + + Q+ A K + + RE +I + Sbjct: 29 FTDDYQLFEEL---GKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICR 85 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRV 129 LLKH N+V L + + G YLVFD L +++ + ++ ++ Sbjct: 86 LLKHPNIVRLHDSISEE--------GFHYLVFDLVTG--GELFEDIVAREYYSEADASHC 135 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYT 186 + +L + +IH++ I+HRD+K N+L+ + +KLADFGLA + + + Sbjct: 136 IHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA----IEVQGEQQAWF 191 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 T Y PE+L + YG P+D+W G I+ + L G Sbjct: 192 GFAGTPGYLSPEVLRKD-PYGKPVDIWACGVILYIL---------------------LVG 229 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAY--------VRDPYALDLIDKLLVL 298 P W + D ++LY+++ + AY P A +LI+++L + Sbjct: 230 --YPPFW-DEDQHKLYQQI------------KAGAYDFPSPEWDTVTPEAKNLINQMLTI 274 Query: 299 DPAQRIDSDDALNH 312 +PA+RI +D AL H Sbjct: 275 NPAKRITADQALKH 288 >4U41-A nrPDB Length = 332 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 109/223 (48%), Gaps = 20/223 (8%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D +E + +G GT+G+V+K RH KTGQ A+K +M+ ++ L EI +L+ Sbjct: 21 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIK--VMDVTEDEEEEIKL-EINMLKKY 77 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF---TLSE--IKR 128 H + K SP ++LV +FC AG +++++ TL E I Sbjct: 78 SHHRNIATYYGAFIKKSPPGH-DDQLWLVMEFCG---AGSITDLVKNTKGNTLKEDWIAY 133 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + + +L GL ++H + ++HRD+K NVL+T + +KL DFG++ + R Sbjct: 134 ISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGRRNTF 189 Query: 189 VVTLWYRPPELLLGERD----YGPPIDLWGAGCIMAEMWTRSP 227 + T ++ PE++ + + Y DLW G EM +P Sbjct: 190 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAP 232 >5U6Y-A nrPDB Length = 461 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 77/307 (25%), Positives = 133/307 (43%), Gaps = 64/307 (20%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ ++G+G F V + GQ+ A K + + RE +I +LLKH N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 V L + + G YL+FD L +++ + ++ ++ +Q +L Sbjct: 62 VRLHDSISEE--------GHHYLIFDLVTG--GELFEDIVAREYYSEADASHCIQQILEA 111 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + + H+ ++HRD+K N+L+ + +KLADFGLA + + + T Sbjct: 112 VLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----IEVEGEQQAWFGFAGTPG 167 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L + YG P+DLW G I+ + L G P W Sbjct: 168 YLSPEVLRKD-PYGKPVDLWACGVILYIL---------------------LVG--YPPFW 203 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAY--------VRDPYALDLIDKLLVLDPAQRID 305 + D + LY+++ + AY P A DLI+K+L ++P++RI Sbjct: 204 -DEDQHRLYQQI------------KAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT 250 Query: 306 SDDALNH 312 + +AL H Sbjct: 251 AAEALKH 257 >4PDS-A nrPDB Length = 347 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 82/320 (25%), Positives = 134/320 (41%), Gaps = 64/320 (20%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG F V KA R TG+ ++K ++ + + G RE+++LQ L H +V L Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVK-IISKRKVIGNMDGVTRELEVLQKLNHPRIVRL--- 94 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLNGLYYIHR 142 + S Y+V +F L+ V + E + + + +L + YIH Sbjct: 95 -----KGFYEDTESYYMVMEFVSG--GDLMDFVAAHGAVGEDAGREISRQILTAIKYIHS 147 Query: 143 NKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVV--TLWYRPPE 198 I HRD+K N+LI +D ++K+ FGLA+ Q N + TL Y PE Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKV-------QGNGSFMKTFCGTLAYVAPE 200 Query: 199 LLLGE------------RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 ++ G+ +Y +D+W GC++ + T G+T+ Sbjct: 201 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQD----------- 249 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 +LY+++ G+ + LK + A D ID LL +DP R + Sbjct: 250 -------------QLYKQI----GRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTA 292 Query: 307 DDALNHDFFWSDPMPSDLKG 326 ALNH + P+ S G Sbjct: 293 AKALNHPWIKMSPLGSQSYG 312 >3BHH-A nrPDB Length = 295 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 81/312 (25%), Positives = 134/312 (42%), Gaps = 67/312 (21%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 DE YE IG+G F V + TG + A K + + RE +I +LL Sbjct: 4 DEYQLYED---IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLL 60 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQ 131 KH N+V L + + G YLVFD L +++ + ++ ++ +Q Sbjct: 61 KHSNIVRLHDSISEE--------GFHYLVFDLVTG--GELFEDIVAREYYSEADASHCIQ 110 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 +L + + H+ ++HRD+K N+L+ + +KLADFGLA + + Sbjct: 111 QILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA----IEVQGDQQAWFGF 166 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 T Y PE+L E YG P+D+W G I+ + L G Sbjct: 167 AGTPGYLSPEVLRKEA-YGKPVDIWACGVILYIL---------------------LVG-- 202 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAY--------VRDPYALDLIDKLLVLDP 300 P W + D ++LY+++ + AY P A +LI+++L ++P Sbjct: 203 YPPFW-DEDQHKLYQQI------------KAGAYDFPSPEWDTVTPEAKNLINQMLTINP 249 Query: 301 AQRIDSDDALNH 312 A+RI + +AL H Sbjct: 250 AKRITAHEALKH 261 >3UDB-A nrPDB Length = 317 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 91/350 (26%), Positives = 151/350 (43%), Gaps = 55/350 (15%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 ++ P + +YE + IG G FG R ++ + VA+K + E REI Sbjct: 10 MDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI---ERGEKIDENVKREI 66 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 + L+H N+V E+ T + +V ++ +L + N +F+ E Sbjct: 67 INHRSLRHPNIVRFKEVILTPTH--------LAIVMEYASGGELFERICNA-GRFSEDEA 117 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQP 182 + Q L++G+ Y H ++ HRD+K N L+ DG LK+ADFG ++A L +SQP Sbjct: 118 RFFFQQLISGVSYAHAMQVAHRDLKLENTLL--DGSPAPRLKIADFGYSKASVL--HSQP 173 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + V T Y PE+LL + G D+W G + M Sbjct: 174 K---SAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM-------------------- 210 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDPA 301 L G+ E N+ + + + + + D YV P LI ++ V DPA Sbjct: 211 -LVGAYPFEDPEEPKNFR--KTIHRILNVQYAIPD----YVHISPECRHLISRIFVADPA 263 Query: 302 QRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQ 351 +RI + NH++F + +P+DL M +T+ F+ P + +I Q Sbjct: 264 KRISIPEIRNHEWFLKN-LPADL--MNDNTMTTQFDESDQPGQSIEEIMQ 310 >5F9E-A nrPDB Length = 353 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 60/227 (26%), Positives = 112/227 (49%), Gaps = 23/227 (10%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKK-----VLMENEKEGFPITALREIKI 69 ++ +E +G+G+FG+VF A +KT Q A+K VLM+++ E + E ++ Sbjct: 17 KIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVE----CTMVEKRV 72 Query: 70 LQL-LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR 128 L L +H + ++ +TK + ++ V ++ KF LS Sbjct: 73 LSLAWEHPFLTHMFCTFQTKEN--------LFFVMEYLNGGDLMYHIQSCHKFDLSRATF 124 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 ++ GL ++H I++RD+K N+L+ +DG +K+ADFG+ + ++ +++ N + Sbjct: 125 YAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKE-NMLGDAKTNEFCG- 182 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 T Y PE+LLG++ Y +D W G ++ EM G E+ Sbjct: 183 --TPDYIAPEILLGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQDEE 226 >2J90-A nrPDB Length = 304 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 130/305 (42%), Gaps = 56/305 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVA---LKKVLMENEKEGFPITAL-REIKILQLLK 74 YE ++G G F V K R + TG++ A +KK + + + G + RE+ IL+ ++ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 87 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQ 131 H N++ L +I K + L+ + G L + L + T E + ++ Sbjct: 88 HPNIITLHDIFENKTD--------VVLILELVS---GGELFDFLAEKESLTEDEATQFLK 136 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTN 187 +L+G++Y+H +I H D+K N+++ V +KL DFG+A K N + N Sbjct: 137 QILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAH-----KIEAGNEFKN 191 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T + PE++ E G D+W G I + + + G T+Q L IS + Sbjct: 192 IFGTPEFVAPEIVNYE-PLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYD 250 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 E + N EL K D I +LLV DP +R+ Sbjct: 251 FDEEYFSNTS--------ELAK--------------------DFIRRLLVKDPKRRMTIA 282 Query: 308 DALNH 312 +L H Sbjct: 283 QSLEH 287 >4I6B-A nrPDB Length = 308 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 75/315 (23%), Positives = 130/315 (41%), Gaps = 60/315 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQL 72 +Y + +G+G F + ++ + A K +V +++E +EI++ ++ Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKID----KEIELHRI 84 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 L H++VV Y K +IY++ ++C + T E++ ++ Sbjct: 85 LHHKHVVQFYH--------YFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQ 136 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-- 190 +++GL Y+H +ILHRD+K N I LK+ DFGLA +P + R + Sbjct: 137 IVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARL------EPLEHRRRTICG 190 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSIT 249 T Y PE +L ++ +G D+W GC+M M R P N + Sbjct: 191 TPNYLSPE-VLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLK--------------- 234 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 E Y + R+ + + + + P A LI +L +P R DD Sbjct: 235 ----------ETYRSI-------REARYTMPSSLLAP-AKHLIASMLSKNPEDRPSLDDI 276 Query: 310 LNHDFFWSDPMPSDL 324 + HDFF P L Sbjct: 277 IRHDFFTQGFTPDRL 291 >2Z7Q-A nrPDB Length = 321 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 71/229 (31%), Positives = 109/229 (47%), Gaps = 18/229 (7%) Query: 17 SKYEKLAKIGQGTFGEVF---KARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 S +E L +GQG+FG+VF K +G A+K + K + E IL + Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADV 87 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM 132 H VV L +T+ G +YL+ DF DL LS V FT ++K + Sbjct: 88 NHPFVVKLHYAFQTE--------GKLYLILDFLRGGDLFTRLSKE-VMFTEEDVKFYLAE 138 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L GL ++H I++RD+K N+L+ +G +KL DFGL++ A + + Y+ T+ Sbjct: 139 LALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE---AIDHEKKAYSF-CGTV 194 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 Y PE ++ + + D W G +M EM T S QG + + LI Sbjct: 195 EYMAPE-VVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLI 242 >4YNZ-A nrPDB Length = 342 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 101/210 (48%), Gaps = 25/210 (11%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V Y +G+G G V H T QKVA+K V E E + REI IL+L++H Sbjct: 9 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 68 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQM 132 +V+ L ++ K +YLV EH G L + LVK T E ++ + Sbjct: 69 PHVLKLHDVYENKKY--------LYLVL---EHVSGGELFDYLVKKGRLTPKEARKFFRQ 117 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR---AFSLAKNSQPNRYTNRV 189 +++ L + H + I HRD+K N+L+ +++ADFG+A SL + S + + Sbjct: 118 IISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPH---- 173 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 Y PE++ GE+ G D+W G I+ Sbjct: 174 ----YACPEVIRGEKYDGRKADVWSCGVIL 199 >2WTK-C nrPDB Length = 305 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 106/213 (49%), Gaps = 12/213 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKT--GQKVALKKVLMENEKEGFPITALREIKILQLL 73 + KY +G+G++G+V + +T + V + K +EI++L+ L Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQM 132 +H+NV+ L+++ YN K +Y+V ++C + +L +V K F + + Sbjct: 64 RHKNVIQLVDVL------YNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQ 117 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L++GL Y+H I+H+D+K N+L+T G LK++ G+A A R + + Sbjct: 118 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQG--SP 175 Query: 193 WYRPPELLLGERDY-GPPIDLWGAGCIMAEMWT 224 ++PPE+ G + G +D+W AG + + T Sbjct: 176 AFQPPEIANGLDTFSGFKVDIWSAGVTLYNITT 208 >4D2V-A nrPDB Length = 356 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 78/310 (25%), Positives = 139/310 (44%), Gaps = 53/310 (17%) Query: 14 DEVSKYEKLAK-IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQ 71 DE+ KY +L + IG G F +V A H TG+ VA+K +M+ G + ++ EI+ L+ Sbjct: 25 DELLKYYELHETIGTGGFAKVKLACHILTGEMVAIK--IMDKNTLGSDLPRIKTEIEALK 82 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKR 128 L+H+++ L + T I++V ++C G L + ++ + + E + Sbjct: 83 NLRHQHICQLYHVLETA--------NKIFMVLEYCP---GGELFDYIISQDRLSEEETRV 131 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 V + +++ + Y+H HRD+K N+L LKL DFGL + K ++ Sbjct: 132 VFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLC---AKPKGNKDYHLQAC 188 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 L Y PEL+ G+ G D+W G ++ + +CG + Sbjct: 189 CGALAYAAPELIQGKSYLGSEADVWSMGILLYVL---------------------MCGFL 227 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 P D+ ++++G K V L P ++ L+ ++L +DP +RI + Sbjct: 228 -----PFDDDTAAALVAKIMRG-KYDVPKWLS-----PSSILLLQQMLQVDPKKRISMKN 276 Query: 309 ALNHDFFWSD 318 LNH + D Sbjct: 277 LLNHPWIMQD 286 >5DYK-A nrPDB Length = 853 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/257 (29%), Positives = 123/257 (47%), Gaps = 26/257 (10%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 E+ + E IG+GTFG V H+ T + ALK V +++ + IK+ + + Sbjct: 537 EMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCV---SKRSIINLNQQNNIKLEREIT 593 Query: 75 HENVV-NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL---SEIKRVM 130 EN +I + RT K S Y F E G L + + K L S+ + + Sbjct: 594 AENDHPFIIRLVRT-------FKDSKYFYF-LTELVTGGELYDAIRKLGLLSKSQAQFYL 645 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 ++ + Y+H I++RD+K N+L+ + G +KL DFG AK Q YT V Sbjct: 646 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFG------CAKKVQGRAYT-LVG 698 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ-LCGSIT 249 T Y PE++LG + YG +D+W G + E + P+ GN E+ QL + L G +T Sbjct: 699 TPHYMAPEVILG-KGYGCTVDIWALGICLYE-FICGPLPFGNDEEDQLEIFRDILTGQLT 756 Query: 250 -PEVWPNVDNYELYEKL 265 P+ + D+ L ++L Sbjct: 757 FPDYVTDTDSINLMKRL 773 >3ZUT-A nrPDB Length = 362 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 91/362 (25%), Positives = 154/362 (42%), Gaps = 55/362 (15%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 ++ P + +YE + IG G FG R +++ + VA+K + E REI Sbjct: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKREI 66 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 + L+H N+V E+ T + +V ++ +L + N +F+ E Sbjct: 67 INHRSLRHPNIVRFKEVILTPTH--------LAIVMEYASGGELFERICNA-GRFSEDEA 117 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQP 182 + Q L++G+ Y H ++ HRD+K N L+ DG LK+ FG +++ L +SQP Sbjct: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLL--DGSPAPRLKICAFGYSKSSVL--HSQP 173 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + V T Y PE+LL + G D+W G + M Sbjct: 174 K---STVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVM-------------------- 210 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR-DPYALDLIDKLLVLDPA 301 L G+ E N+ + + + + + D YV P LI ++ V DPA Sbjct: 211 -LVGAYPFEDPEEPKNFR--KTIHRILNVQYAIPD----YVHISPECRHLISRIFVADPA 263 Query: 302 QRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPA 361 +RI + NH++F + +P+DL M +T+ F+ P + +I Q + PA Sbjct: 264 KRISIPEIRNHEWFLKN-LPADL--MNDNTMTTQFDESDQPGQSIEEIMQIIAEATVPPA 320 Query: 362 TT 363 T Sbjct: 321 GT 322 >5HVK-A nrPDB Length = 315 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 110/213 (51%), Gaps = 24/213 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G+G FG+ K HR+TG+ + +K+++ +E+ T L+E+K+++ L+H NV+ I + Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTFLKEVKVMRCLEHPNVLKFIGV 79 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 + + ++ + L G++ ++ ++ S+ + + +G+ Y+H Sbjct: 80 LYKDKR--------LNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 131 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAF-----------SLAKNSQPNRYTNRVVTL 192 I+HR++ + N L+ + + +ADFGLAR SL K + RYT V Sbjct: 132 NIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTV-VGNP 190 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTR 225 ++ PE++ G R Y +D++ G ++ E+ R Sbjct: 191 YWMAPEMING-RSYDEKVDVFSFGIVLCEIIGR 222 >3SOA-A nrPDB Length = 444 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 133/308 (43%), Gaps = 64/308 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y+ ++G+G F V + GQ+ A + + RE +I +LLKH N Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPN 71 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLN 135 +V L + + G YL+FD L +++ + ++ ++ +Q +L Sbjct: 72 IVRLHDSISEE--------GHHYLIFDLVTG--GELFEDIVAREYYSEADASHCIQQILE 121 Query: 136 GLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + + H+ ++HR++K N+L+ + +KLADFGLA + + + T Sbjct: 122 AVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA----IEVEGEQQAWFGFAGTP 177 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE+L + YG P+DLW G I+ + L G P Sbjct: 178 GYLSPEVLRKD-PYGKPVDLWACGVILYIL---------------------LVG--YPPF 213 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAY--------VRDPYALDLIDKLLVLDPAQRI 304 W + D + LY+++ + AY P A DLI+K+L ++P++RI Sbjct: 214 W-DEDQHRLYQQI------------KAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRI 260 Query: 305 DSDDALNH 312 + +AL H Sbjct: 261 TAAEALKH 268 >3EQC-A nrPDB Length = 360 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 86/331 (25%), Positives = 143/331 (43%), Gaps = 36/331 (10%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L + Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYI 93 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLN 135 V + Y+ + SI + EH G L VL K + +V ++ Sbjct: 94 VGFY------GAFYSDGEISICM-----EHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 142 Query: 136 GLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+ ++KI+HRD+K +N+L+ G +KL DFG++ +S N + V T Y Sbjct: 143 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---DSMANSF---VGTRSY 196 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVW 253 PE L G Y D+W G + EM R PI + ++ +L Q+ G Sbjct: 197 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 255 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP--------YAL---DLIDKLLVLDPAQ 302 K + + + L V +P ++L D ++K L+ +PA+ Sbjct: 256 RPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 315 Query: 303 RIDSDDALNHDFF-WSDPMPSDLKGMLSTHL 332 R D + H F SD D G L + + Sbjct: 316 RADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 346 >4C0T-A nrPDB Length = 974 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 81/309 (26%), Positives = 138/309 (44%), Gaps = 64/309 (20%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH-----ENV 78 ++G+G++ V A + TG++ A+K VL + I +++K + + KH N Sbjct: 273 ELGEGSYSTVILATDKITGKQYAVK-VLDKRH-----IIKEKKVKYVNIEKHALNRLSNR 326 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF-TLSE--IKRVMQMLLN 135 + +I + T + K S+Y V D+ + G L ++ ++ TL+E + +L+ Sbjct: 327 LGVISLYFTF-----QDKDSLYFVLDYASN---GELLTLIKRYNTLNEECTRHFGAQILD 378 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY------TNRV 189 + Y+H N ++HRD+K N+L+ +++ DFG AR KN + Y + V Sbjct: 379 AIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLE-KKNDESEEYPVDVRAKSFV 437 Query: 190 VTLWYRPPELLLGERDY-GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 T Y PELL E Y G P D+W GCI+ +M P + E I++L + Sbjct: 438 GTAEYVSPELL--ENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAF 495 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 + +P + +R DLI K+LVL P++R + Sbjct: 496 SAG-FPTI--------------------------IR-----DLIKKILVLQPSRRATIPE 523 Query: 309 ALNHDFFWS 317 H FF S Sbjct: 524 IQKHYFFQS 532 >6FDY-U nrPDB Length = 276 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 85/305 (27%), Positives = 136/305 (44%), Gaps = 52/305 (17%) Query: 24 KIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 ++G GT+ V+KA +K T + VA+K V ++ + L EI+IL+ ++H ++V L Sbjct: 18 RLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLK 77 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-VKFTLSE-IKRV-MQMLLNGLYY 139 + + +IYL+ +FC G LS + + L E + RV MQ L + L + Sbjct: 78 D--------FQWDSDNIYLIMEFCA---GGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 140 IHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 +H I H D+K N+L++ LKLADFG A+ S ++ R L Y P Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMS----PWDEKHVLRGSPL-YMAP 181 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E++ +R Y +DLW G I+ E P + Sbjct: 182 EMVC-QRQYDARVDLWSMGVILYEALFGQPPFASRSFS---------------------- 218 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 EL EK+ + + ++ L R DL+ +LL DP++RI D H + Sbjct: 219 --ELEEKIRSNRVIELPLRPLLSRDCR-----DLLQRLLERDPSRRISFQDFFAHPWVDL 271 Query: 318 DPMPS 322 + MPS Sbjct: 272 EHMPS 276 >5X02-A nrPDB Length = 347 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 103/228 (45%), Gaps = 39/228 (17%) Query: 25 IGQGTFGEVFKARH---RKTGQKVALK-KVLMENEKEGFPITALREIKIL-QLLKHENVV 79 +G G FG+V A KTG + + K+L E + E+K++ QL HEN+V Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 115 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLN--- 135 NL+ C G IYL+F++C + DL L + KF+ EI+ Q L Sbjct: 116 NLLGACTLS--------GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 167 Query: 136 -------------------GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 G+ ++ +HRD+ A NVL+T V+K+ DFGLAR + Sbjct: 168 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI-M 226 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + ++ R R+ W P L G Y D+W G ++ E+++ Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLFEG--IYTIKSDVWSYGILLWEIFS 272 >4FZF-B nrPDB Length = 283 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 111/229 (48%), Gaps = 30/229 (13%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + KL +IG+G+FGEVFK +T Q VA+K I L E + + + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIK------------IIDLEEAEDEIEDIQQEI 57 Query: 79 VNLIEICRTKASPY--NRCKGS-IYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQM 132 L + + + Y + KGS ++++ ++ L G + L++ F +I +++ Sbjct: 58 TVLSQCDSSYVTKYYGSYLKGSKLWIIMEY----LGGGSALDLLRAGPFDEFQIATMLKE 113 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +L GL Y+H K +HRD+KAANVL++ G +KLA FG+A + ++Q R T Sbjct: 114 ILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLT---DTQIKRNTFVGTPF 170 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 W P ++ + Y D+W G E+ P N++ H + ++ Sbjct: 171 WMAPE--VIQQSAYDSKADIWSLGITAIELAKGEP---PNSDMHPMRVL 214 >4QMW-A nrPDB Length = 310 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 100/215 (46%), Gaps = 27/215 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + KL KIG+G+FGEVFK +T + VA+K I L E + + + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIK------------IIDLEEAEDEIEDIQQEI 78 Query: 79 VNLIEICRTKASPYNRCKGSIYL----VFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQM 132 L + C SPY YL ++ E+ G ++L L E I +++ Sbjct: 79 TVLSQ-CD---SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILRE 134 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +L GL Y+H K +HRD+KAANVL++ G +KLADFG+A + ++Q R T Sbjct: 135 ILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLT---DTQIKRNTFVGTPF 191 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 W P ++ + Y D+W G E+ P Sbjct: 192 WMAPE--VIKQSAYDSKADIWSLGITAIELARGEP 224 >4AF3-A nrPDB Length = 292 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 71/217 (32%), Positives = 106/217 (48%), Gaps = 24/217 (11%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLK 74 + +E +G+G FG V+ AR +K+ VALK + EKEG REI+I L Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQ 131 H N++ L Y+R + IYL+ ++ G L L K F +M+ Sbjct: 82 HPNILRLYNYF------YDRRR--IYLILEYAPR---GELYKELQKSCTFDEQRTATIME 130 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA-RAFSLAKNSQPNRYTNRVV 190 L + L Y H K++HRD+K N+L+ G LK+ADFG + A SL + + Sbjct: 131 ELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCG------- 183 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 TL Y PPE++ G R + +DLW G + E+ +P Sbjct: 184 TLDYLPPEMIEG-RMHNEKVDLWCIGVLCYELLVGNP 219 >6CMJ-A nrPDB Length = 321 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 67/231 (29%), Positives = 107/231 (46%), Gaps = 27/231 (11%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKT----GQKVALKKVLMEN-----EKEGFPITA 63 C ++ +Y +IG+G++G V A + KV KK L+ + G Sbjct: 30 CVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQV 89 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL 123 +EI IL+ L H NVV L+E+ + +Y+VF+ G + V L Sbjct: 90 YQEIAILKKLDHPNVVKLVEVLDDPNEDH------LYMVFELVNQ---GPVMEVPTLKPL 140 Query: 124 SE--IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 SE + Q L+ G+ Y+H KI+HRD+K +N+L+ DG +K+ADFG++ F Sbjct: 141 SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK----GS 196 Query: 182 PNRYTNRVVTLWYRPPELLLGERDY--GPPIDLWGAGCIM-AEMWTRSPIM 229 +N V T + PE L R G +D+W G + ++ + P M Sbjct: 197 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 >4E93-A nrPDB Length = 377 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/237 (27%), Positives = 106/237 (44%), Gaps = 18/237 (7%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 +IG+G FGEVF R R VA+K E L+E +IL+ H N+V LI Sbjct: 121 QIGRGNFGEVFSGRLRADNTLVAVKSC-RETLPPDLKAKFLQEARILKQYSHPNIVRLIG 179 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLYYI 140 +C T+ P IY+V + + L+ + + +K ++QM+ + G+ Y+ Sbjct: 180 VC-TQKQP-------IYIVMELVQG--GDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 229 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 +HRD+ A N L+T VLK++DFG++R + + +V W P L Sbjct: 230 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG-LRQVPVKWTAPEALN 288 Query: 201 LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI-TPEVWPNV 256 G Y D+W G ++ E ++ N Q + G + PE+ P+ Sbjct: 289 YGR--YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDA 343 >3MDY-A nrPDB Length = 337 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 70/237 (29%), Positives = 117/237 (49%), Gaps = 34/237 (14%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ--LLKHEN 77 + + +IG+G +GEV+ + R G+KVA+K E F RE +I Q L++HEN Sbjct: 40 QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWF-----RETEIYQTVLMRHEN 92 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML---L 134 ++ I + + +YL+ D+ E+ G L + L TL + K ++++ + Sbjct: 93 ILGFIAADIKGTGSWTQ----LYLITDYHEN---GSLYDYLKSTTL-DAKSMLKLAYSSV 144 Query: 135 NGLYYIH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 +GL ++H + I HRD+K+ N+L+ ++G +AD GLA F N Sbjct: 145 SGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPN 204 Query: 187 NRVVTLWYRPPELL---LGERDYGPPI--DLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 RV T Y PPE+L L + I D++ G I+ E+ R + G E++QL Sbjct: 205 TRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEV-ARRCVSGGIVEEYQL 260 >4XUF-A nrPDB Length = 297 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 66/228 (28%), Positives = 103/228 (45%), Gaps = 39/228 (17%) Query: 25 IGQGTFGEVFKARH---RKTGQKVALK-KVLMENEKEGFPITALREIKIL-QLLKHENVV 79 +G G FG+V A KTG + + K+L E + E+K++ QL HEN+V Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 76 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLN--- 135 NL+ C G IYL+F++C + DL L + KF+ EI+ Q L Sbjct: 77 NLLGACTLS--------GPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEE 128 Query: 136 -------------------GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 G+ ++ +HRD+ A NVL+T V+K+ DFGLAR + Sbjct: 129 DLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI-M 187 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + ++ R R+ W P L E Y D+W G ++ E+++ Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLF--EGIYTIKSDVWSYGILLWEIFS 233 >4EQM-A nrPDB Length = 294 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/226 (29%), Positives = 106/226 (46%), Gaps = 31/226 (13%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALREIKILQLLKHE 76 +Y+ + K+G G V+ A KVA+K + + EKE RE+ L H+ Sbjct: 12 RYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQ 71 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-------DLAGLLS-NVLVKFTLSEIKR 128 N+V++I++ + C YLV ++ E + G LS + + FT Sbjct: 72 NIVSMIDV-----DEEDDC---YYLVMEYIEGPTLSEYIESHGPLSVDTAINFT------ 117 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 +L+G+ + H +I+HRD+K N+LI + LK+ DFG+A+A S +Q TN Sbjct: 118 --NQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQ----TNH 171 Query: 189 VV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNT 233 V+ T+ Y PE GE D++ G ++ EM P G T Sbjct: 172 VLGTVQYFSPEQAKGEA-TDECTDIYSIGIVLYEMLVGEPPFNGET 216 >2W1I-A nrPDB Length = 326 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 110/238 (46%), Gaps = 31/238 (13%) Query: 22 LAKIGQGTFGEVFKARHR----KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 L ++G+G FG V R+ TG+ VA+KK+ E+ REI+IL+ L+H+N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE--REIEILKSLQHDN 103 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIK--RVMQML 133 +V +C Y+ + ++ L+ ++ + G L + L K + IK + + Sbjct: 104 IVKYKGVC------YSAGRRNLKLIMEYLPY---GSLRDYLQKHKERIDHIKLLQYTSQI 154 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ + +HRD+ N+L+ + +K+ DFGL + K + W Sbjct: 155 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 214 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT-----RSPI-----MQGNTEQHQLALI 241 Y P L E + D+W G ++ E++T +SP M GN +Q Q+ + Sbjct: 215 YAPESLT--ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVF 270 >2JAM-A nrPDB Length = 304 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 118/300 (39%), Gaps = 56/300 (18%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLIE 83 +G G F EVF + R TG+ ALK + + F ++L EI +L+ +KHEN+V L + Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCI---KKSPAFRDSSLENEIAVLKKIKHENIVTLED 73 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGLYYIH 141 I + YLV L +L + +T + V+Q +L+ + Y+H Sbjct: 74 IYESTTH--------YYLVMQLVSG--GELFDRILERGVYTEKDASLVIQQVLSAVKYLH 123 Query: 142 RNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 N I+HRD+K N+L + + + DFG L+K Q + T Y PE Sbjct: 124 ENGIVHRDLKPENLLYLTPEENSKIMITDFG------LSKMEQNGIMSTACGTPGYVAPE 177 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 +L ++ Y +D W G I + P TE I + W ++ Sbjct: 178 -VLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISE 236 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSD 318 A D I LL DP +R + AL+H W D Sbjct: 237 ----------------------------SAKDFICHLLEKDPNERYTCEKALSHP--WID 266 >2H8H-A nrPDB Length = 535 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 101/209 (48%), Gaps = 23/209 (11%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVVNL 81 K+GQG FGEV+ T +VA+K + K G P L+E ++++ L+HE +V L Sbjct: 274 KLGQGCFGEVWMGTWNGT-TRVAIKTL-----KPGTMSPEAFLQEAQVMKKLRHEKLVQL 327 Query: 82 IEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKF-TLSEIKRVMQMLLNGLYY 139 + + IY+V ++ + L L K+ L ++ + + +G+ Y Sbjct: 328 YAVVSEEP---------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 378 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + R +HRD++AAN+L+ + V K+ADFGLAR + N R + W P Sbjct: 379 VERMNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAA 436 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 L G + D+W G ++ E+ T+ + Sbjct: 437 LYGR--FTIKSDVWSFGILLTELTTKGRV 463 >5KKR-C nrPDB Length = 395 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 89/331 (26%), Positives = 145/331 (43%), Gaps = 36/331 (10%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L HE Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVL----HE-- 122 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLN 135 N I + Y+ + SI + EH G L VL K + +V ++ Sbjct: 123 CNSPYIVGFYGAFYSDGEISICM-----EHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 177 Query: 136 GLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+ ++KI+HRD+K +N+L+ G +KL DFG++ +S N + V T Y Sbjct: 178 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---DSMANSF---VGTRSY 231 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVW 253 PE L G Y D+W G + EM R PI + ++ +L Q+ G Sbjct: 232 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPP 290 Query: 254 P-----------NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 +D+ EL+ + +L + V D ++K L+ +PA+ Sbjct: 291 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAE 350 Query: 303 RIDSDDALNHDFF-WSDPMPSDLKGMLSTHL 332 R D + H F SD D G L + + Sbjct: 351 RADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 381 >2BDW-A nrPDB Length = 362 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 128/299 (42%), Gaps = 53/299 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ ++G+G F V + H+ TG + A K + + RE +I + L+H N+ Sbjct: 31 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 90 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 V L + + ++ Y LVFD L +++ + ++ ++ +Q +L Sbjct: 91 VRLHDSIQEESFHY--------LVFDLVTG--GELFEDIVAREFYSEADASHCIQQILES 140 Query: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y H N I+HR++K N+L+ + +KLADFGLA + + + T Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA-----IEVNDSEAWHGFAGTPG 195 Query: 194 YRPPELLLGERD-YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL-ALISQLCGSITPE 251 Y PE+L ++D Y P+D+W G I+ + P + +QH+L A I Sbjct: 196 YLSPEVL--KKDPYSKPVDIWACGVILYILLVGYPPFW-DEDQHRLYAQIKAGAYDYPSP 252 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V P A LID +L ++P +RI +D AL Sbjct: 253 EWDTV----------------------------TPEAKSLIDSMLTVNPKKRITADQAL 283 >3UC3-A nrPDB Length = 361 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 92/365 (25%), Positives = 156/365 (42%), Gaps = 58/365 (15%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI--TALR 65 ++ P + +Y+ + IG G FG R + T + VA+K + + G I R Sbjct: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI-----ERGAAIDENVQR 65 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLS 124 EI + L+H N+V E+ T + ++ ++ +L + N +F+ Sbjct: 66 EIINHRSLRHPNIVRFKEVILTPTH--------LAIIMEYASGGELYERICNA-GRFSED 116 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNS 180 E + Q LL+G+ Y H +I HRD+K N L+ DG LK+ DFG +++ L +S Sbjct: 117 EARFFFQQLLSGVSYCHSMQICHRDLKLENTLL--DGSPAPRLKICDFGYSKSSVL--HS 172 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 QP + V T Y PE+LL + G D+W G + M Sbjct: 173 QPK---STVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVM------------------ 211 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 L G+ E +Y + ++ + K + D ++ P LI ++ V DP Sbjct: 212 ---LVGAYPFEDPEEPRDYR--KTIQRILSVKYSIPDDIRI---SPECCHLISRIFVADP 263 Query: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360 A RI + H +F + +P+DL M ++ S F+ P + I Q +++ P Sbjct: 264 ATRISIPEIKTHSWFLKN-LPADL--MNESNTGSQFQEPEQPMQSLDTI-MQIISEATIP 319 Query: 361 ATTNQ 365 A N+ Sbjct: 320 AVRNR 324 >6CTH-A nrPDB Length = 309 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 114/249 (45%), Gaps = 31/249 (12%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S + K+G+G FG V++ R + +A+KKV K+G A E+KI+ L+H+ Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKV-SRASKQGIKEYA-SEVKIISRLRHK 72 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQM 132 N+V LI C + G + LV++F + G L + + K T R+++ Sbjct: 73 NLVKLIGWCHER--------GELMLVYEFMAN---GSLDSHIFKGKSLLTWEVRYRIVKD 121 Query: 133 LLNGLYYIHRNK---ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 L + L Y+H +LHRD+K +N+++ KL DFGLAR AK + Sbjct: 122 LASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG-- 179 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T+ Y PE L + D++ G + E+ + ++ E+ + L + Sbjct: 180 -TVGYMAPECLSSGKA-SKESDVYSFGVVALEIASGRRSIEPKFEESEALL-------LV 230 Query: 250 PEVWPNVDN 258 P VW + N Sbjct: 231 PWVWESYGN 239 >3KK8-A nrPDB Length = 284 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 128/299 (42%), Gaps = 53/299 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ ++G+G F V + H+ TG + A K + + RE +I + L+H N+ Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 67 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 V L + + ++ Y LVFD L +++ + ++ ++ +Q +L Sbjct: 68 VRLHDSIQEESFHY--------LVFDLVTG--GELFEDIVAREFYSEADASHCIQQILES 117 Query: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y H N I+HR++K N+L+ + +KLADFGLA + + + T Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLA-----IEVNDSEAWHGFAGTPG 172 Query: 194 YRPPELLLGERD-YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL-ALISQLCGSITPE 251 Y PE+L ++D Y P+D+W G I+ + P + +QH+L A I Sbjct: 173 YLSPEVL--KKDPYSKPVDIWACGVILYILLVGYPPFW-DEDQHRLYAQIKAGAYDYPSP 229 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V P A LID +L ++P +RI +D AL Sbjct: 230 EWDTV----------------------------TPEAKSLIDSMLTVNPKKRITADQAL 260 >4CSV-A nrPDB Length = 275 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 105/226 (46%), Gaps = 43/226 (19%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLLKHENVVNL 81 K+G G FGEV++ + R +VA+K + KEG L+E +I++ LKH N+V L Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTL-----KEGTMSVEEFLQEAQIMKKLKHPNLVQL 72 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEH--------DLAGLLSNVLVKFTLSEIKRVMQML 133 +C TK P IY++ ++ H D G N ++ + Sbjct: 73 YGVC-TKEPP-------IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMA------AQV 118 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV---V 190 +G+ Y+ +HRD+ A N L+ + V+K+ADFGLAR + + YT R Sbjct: 119 ASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLIN------EDEYTARAGAKF 172 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS----PIMQGN 232 + + PE + R + D+W G ++ E++T P M G+ Sbjct: 173 PIKWTAPEAISYNR-FSIKSDVWAFGILLWEIFTYGQVPYPGMSGS 217 >3IO7-A nrPDB Length = 313 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 110/238 (46%), Gaps = 31/238 (13%) Query: 22 LAKIGQGTFGEVFKARHR----KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 L ++G+G FG V R+ TG+ VA+KK+ E+ REI+IL+ L+H+N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFE--REIEILKSLQHDN 90 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIK--RVMQML 133 +V +C Y+ + ++ L+ ++ + G L + L K + IK + + Sbjct: 91 IVKYKGVC------YSAGRRNLKLIMEYLPY---GSLRDYLQKHKERIDHIKLLQYTSQI 141 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ + +HRD+ N+L+ + +K+ DFGL + K + W Sbjct: 142 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 201 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT-----RSPI-----MQGNTEQHQLALI 241 Y P L E + D+W G ++ E++T +SP M GN +Q Q+ + Sbjct: 202 YAPESLT--ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVF 257 >3LM0-A nrPDB Length = 327 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 75/307 (24%), Positives = 127/307 (41%), Gaps = 66/307 (21%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH-ENVVNLI 82 ++G+G F V + + TGQ+ A K + + L EI +L+L K V+NL Sbjct: 36 ELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLH 95 Query: 83 EICRTKASPYNRCKGSIYL--------VFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 E+ Y I + +F C +LA ++S +++ R+++ +L Sbjct: 96 EV-------YENTSEIILILEYAAGGEIFSLCLPELAEMVSE-------NDVIRLIKQIL 141 Query: 135 NGLYYIHRNKILHRDMKAANVLITRD---GVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 G+YY+H+N I+H D+K N+L++ G +K+ DFG++R K + T Sbjct: 142 EGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSR-----KIGHACELREIMGT 196 Query: 192 LWYRPPELLLGERDYGP---PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 Y PE+L +Y P D+W G I + T + G Q ISQ+ Sbjct: 197 PEYLAPEIL----NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDY 252 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 + E + +V A D I LLV +P +R ++ Sbjct: 253 SEETFSSVSQ----------------------------LATDFIQSLLVKNPEKRPTAEI 284 Query: 309 ALNHDFF 315 L+H + Sbjct: 285 CLSHSWL 291 >3A4O-X nrPDB Length = 286 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 77/276 (27%), Positives = 126/276 (45%), Gaps = 34/276 (12%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG-FPITA-LREIKILQLLKHENVV 79 + ++G G FGEV+ + + KVA+K + K G + A L E +++ L+H+ +V Sbjct: 18 VKRLGAGQFGEVWMGYYNNS-TKVAVKTL-----KPGTMSVQAFLEEANLMKTLQHDKLV 71 Query: 80 NLIEICRTKASPY----NRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 L + + Y KGS+ DF + D G K L ++ + Sbjct: 72 RLYAVVTREEPIYIITEYMAKGSL---LDFLKSDEGG-------KVLLPKLIDFSAQIAE 121 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ YI R +HRD++AANVL++ + K+ADFGLAR + N R + W Sbjct: 122 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARV--IEDNEYTAREGAKFPIKWTA 179 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI-MQGNTEQHQLALISQLCGSITPEVWP 254 P + G + D+W G ++ E+ T I G T + +SQ G P V Sbjct: 180 PEAINFG--CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQ--GYRMPRVEN 235 Query: 255 NVDNYELYEKLELV---KGQKRKVKDRLKAYVRDPY 287 D ELY+ +++ K ++R D L++ + D Y Sbjct: 236 CPD--ELYDIMKMCWKEKAEERPTFDYLQSVLDDFY 269 >4TPT-A nrPDB Length = 303 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 105/218 (48%), Gaps = 35/218 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G+G FG+ K H+ TG+ + +K+++ +E+ T L E+K+++ L H NV+ I + Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEET--QKTFLTEVKVMRSLDHPNVLKFIGV 65 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYYIH 141 + L+ ++ E G L + L F + R + + +G+ Y+H Sbjct: 66 LYKDKK--------LNLLTEYIE---GGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLH 114 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAF-----------------SLAKNSQPNR 184 I+HRD+ + N LI D + +ADFGL+R +L KN + R Sbjct: 115 SMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 YT V ++ PE+L G + Y +D++ G ++ E+ Sbjct: 175 YT-VVGNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEI 210 >6F3F-A nrPDB Length = 455 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 101/209 (48%), Gaps = 23/209 (11%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVVNL 81 K+GQG FGEV+ T +VA+K + K G P L+E ++++ L+HE +V L Sbjct: 194 KLGQGCFGEVWMGTWNGT-TRVAIKTL-----KPGTMSPEAFLQEAQVMKKLRHEKLVQL 247 Query: 82 IEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKF-TLSEIKRVMQMLLNGLYY 139 + + IY+V ++ + L L K+ L ++ + + +G+ Y Sbjct: 248 YAVVSEEP---------IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAY 298 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + R +HRD++AAN+L+ + V K+ADFGLAR + N R + W P Sbjct: 299 VERMNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAA 356 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 L G + D+W G ++ E+ T+ + Sbjct: 357 LYGR--FTIKSDVWSFGILLTELTTKGRV 383 >2JDO-A nrPDB Length = 342 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 83/333 (24%), Positives = 150/333 (45%), Gaps = 63/333 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK----KVLMENEKEGFPITALREIKILQ 71 ++ ++ L +G+GTFG+V R + TG+ A+K +V++ ++ +T E ++LQ Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVT---ESRVLQ 65 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 +H + L +T ++R + V ++ +L LS V FT + Sbjct: 66 NTRHPFLTALKYAFQT----HDR----LCFVMEYANGGELFFHLSRERV-FTEERARFYG 116 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +++ L Y+H +++RD+K N+++ +DG +K+ DFGL + ++ + + Sbjct: 117 AEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE-GISDGATMKTFCG--- 172 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE +L + DYG +D WG G +M EM +CG + Sbjct: 173 TPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEM---------------------MCGRLP- 209 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----D 305 + N D+ L+ EL+ ++ + L P A L+ LL DP QR+ D Sbjct: 210 --FYNQDHERLF---ELILMEEIRFPRTLS-----PEAKSLLAGLLKKDPKQRLGGGPSD 259 Query: 306 SDDALNHDFF----WSDPMPSDLKGMLSTHLTS 334 + + + H FF W D + L +TS Sbjct: 260 AKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTS 292 >5VO2-A nrPDB Length = 300 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/206 (31%), Positives = 103/206 (50%), Gaps = 31/206 (15%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L +G G G VF R G++VA+KKV + KE +IK L+ LKH N++ Sbjct: 17 LQWVGSGAQGAVFLGRFH--GEEVAVKKV--RDLKE-------TDIKHLRKLKHPNIITF 65 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLY 138 +C T+A Y C ++ +FC G L VL T S + + G+ Sbjct: 66 KGVC-TQAPCY--C-----ILMEFCAQ---GQLYEVLRAGRPVTPSLLVDWSMGIAGGMN 114 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y+H +KI+HRD+K+ N+LIT D V+K++DFG ++ L+ S + V + PE Sbjct: 115 YLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK--ELSDKSTKMSFAGTVA---WMAPE 169 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWT 224 ++ E +D+W G ++ E+ T Sbjct: 170 VIRNE-PVSEKVDIWSFGVVLWELLT 194 >5UIU-A nrPDB Length = 323 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 107/218 (49%), Gaps = 23/218 (10%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKK------VLMENEKEGFPITALREIKILQLLKHEN 77 K+G+G FG V+K T VA+KK + E K+ F +EIK++ +HEN Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFD----QEIKVMAKCQHEN 107 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 L+E+ + + C +Y+ L+ L + + + ++ Q NG+ Sbjct: 108 ---LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMR--CKIAQGAANGI 162 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TLWYRP 196 ++H N +HRD+K+AN+L+ K++DFGLARA ++ T+R+V T Y Sbjct: 163 NFLHENHHIHRDIKSANILLDEAFTAKISDFGLARA---SEKFAQTVMTSRIVGTTAYMA 219 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 PE L GE P D++ G ++ E+ T P + + E Sbjct: 220 PEALRGE--ITPKSDIYSFGVVLLEIITGLPAVDEHRE 255 >5DBX-A nrPDB Length = 328 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 102/227 (44%), Gaps = 20/227 (8%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 +V P C + YE IG G V A + ++VA+K++ +E + L+E Sbjct: 3 AVGWPICRDA--YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD-ELLKE 59 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCK----GSIYLVFDFC----EHDLAGLLSNVL 118 I+ + H NVV K + K GS+ + + EH G+L + Sbjct: 60 IQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHK-NGVLEEAI 118 Query: 119 VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + L E+ L GL Y+HRN +HRD+KA N+L+ DG +++ADFG++ + Sbjct: 119 IATILKEV-------LEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGG 171 Query: 179 NSQPNRYTNRVV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + N+ V T + PE++ R Y D+W G E+ T Sbjct: 172 DVTRNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELAT 218 >5SYS-A nrPDB Length = 286 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 23/209 (11%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVVNL 81 K+GQG FGE + T +VA+K + K G P L+E ++++ L+HE +V L Sbjct: 25 KLGQGCFGECWMGTWNGT-TRVAIKTL-----KPGTMSPEAFLQEAQVMKKLRHEKLVQL 78 Query: 82 IEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFT-LSEIKRVMQMLLNGLYY 139 + + IY+V ++ + L L + K+ L ++ + + +G+ Y Sbjct: 79 YAVVSEE---------PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAY 129 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + R +HRD++AAN+L+ + V K+ADFGLAR + N R + W P Sbjct: 130 VERMNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAA 187 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 L G + D+W G ++ E+ T+ + Sbjct: 188 LYGR--FTIKSDVWSFGILLTELTTKGRV 214 >1K9A-A nrPDB Length = 450 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 100/213 (46%), Gaps = 39/213 (18%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L IG+G FG+V +R G KVA+K + + + F L E ++ L+H N+V L Sbjct: 198 LQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHSNLVQL 251 Query: 82 IEICRTKASPYNRCKGSIYLVFDFC----------EHDLAGLLSNVLVKFTLSEIKRVMQ 131 + + + KG +Y+V ++ + L + L+KF+L Sbjct: 252 LGVIVEE-------KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD------- 297 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + + Y+ N +HRD+ A NVL++ D V K++DFGL + S ++ T ++ Sbjct: 298 -VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPV 350 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 W P L E+ + D+W G ++ E+++ Sbjct: 351 KWTAPEALR--EKKFSTKSDVWSFGILLWEIYS 381 >5FET-A nrPDB Length = 847 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 74/266 (27%), Positives = 119/266 (44%), Gaps = 44/266 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGF----PITALR 65 E+ + E IG+GTFG V H+ T + ALK ++ N++ ITA Sbjct: 531 EMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEN 590 Query: 66 E----IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF 121 + I++++ K N + T Y+ + GLLS +F Sbjct: 591 DHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRK-------------LGLLSKPQAQF 637 Query: 122 TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 L I ++ Y+H I++RD+K N+L+ + G +KL DFG AK Q Sbjct: 638 YLGSIILAIE-------YLHERNIVYRDLKPENILLDKQGYVKLIDFG------CAKKIQ 684 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 YT V T Y PE++LG + YG +D+W G + E + P+ GN ++ QL + Sbjct: 685 GRAYT-LVGTPHYMAPEVILG-KGYGCTVDIWALGVCLYE-FICGPLPFGNDQEDQLEIF 741 Query: 242 SQ-LCGSIT-PEVWPNVDNYELYEKL 265 L G +T P+ + D+ L ++L Sbjct: 742 RDILTGQLTFPDYVSDQDSINLMKRL 767 >5D9K-A nrPDB Length = 330 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 107/229 (46%), Gaps = 18/229 (7%) Query: 17 SKYEKLAKIGQGTFGEVF---KARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 S++E L +GQG+FG+VF K Q A+K + K + E IL + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM 132 H +V L +T+ G +YL+ DF DL LS V FT ++K + Sbjct: 90 NHPFIVKLHYAFQTE--------GKLYLILDFLRGGDLFTRLSKE-VMFTEEDVKFYLAE 140 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L L ++H I++RD+K N+L+ +G +KL DFGL++ S+ + + T+ Sbjct: 141 LALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE-SIDHEKKAYSFCG---TV 196 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 Y PE ++ R + D W G +M EM T + QG + + +I Sbjct: 197 EYMAPE-VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMI 244 >4JLC-A nrPDB Length = 657 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 34/220 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLKHENVVNLIE 83 +GQG VF+ RH+KTG A+K + N P+ +RE ++L+ L H+N+V L Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 73 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGL 137 I + + L+ +FC G L VL + SE V++ ++ G+ Sbjct: 74 IEEETTTRHK------VLIMEFCP---CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 138 YYIHRNKILHRDMKAANVL--ITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ N I+HRD+K N++ I DG V KL DFG AR ++ + T Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEE 179 Query: 194 YRPPELLL-------GERDYGPPIDLWGAGCIMAEMWTRS 226 Y P++ ++ YG +DLW G T S Sbjct: 180 YLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGS 219 >5LOH-A nrPDB Length = 341 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 114/237 (48%), Gaps = 26/237 (10%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK---KVLMENEKEGFPITAL 64 + P + ++ + I +G FG+V+ + K G+ A+K K M N+ + A Sbjct: 27 IAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAE 84 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS 124 R+ L L K +V+L ++ ++YLV ++ + G + ++L + Sbjct: 85 RDA--LALSKSPFIVHLYYSLQSA--------NNVYLVMEYL---IGGDVKSLLHIYGYF 131 Query: 125 E----IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 + +K + ++ L L Y+HR+ I+HRD+K N+LI+ +G +KL DFGL++ + Sbjct: 132 DEEMAVKYISEVAL-ALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDIN 190 Query: 181 QPNRYTNRVV--TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 + T R T Y PELLLG R +GP +D W G + E T P T Q Sbjct: 191 MMDILTTRTFCGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQ 246 >6DBM-A nrPDB Length = 318 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 99/215 (46%), Gaps = 24/215 (11%) Query: 20 EKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLME---NEKEGFPITALREIKILQL 72 +K+ +G+G FG+V + + TG+ VA+K + + + G+ +EI IL+ Sbjct: 34 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK----QEIDILRT 89 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIKRVM 130 L HE+++ C + S+ LV ++ G L + L + + L+++ Sbjct: 90 LYHEHIIKYKGCCEDAGA------ASLQLVMEYVP---LGSLRDYLPRHSIGLAQLLLFA 140 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q + G+ Y+H +HRD+ A NVL+ D ++K+ DFGLA+A R Sbjct: 141 QQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 200 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTR 225 WY P L E + D+W G + E+ T Sbjct: 201 VFWYAPE--CLKEYKFYYASDVWSFGVTLYELLTH 233 >1PHK-A nrPDB Length = 298 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 127/313 (40%), Gaps = 60/313 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-------LMENEKEGFPITALREIKILQ 71 YE +G+G V + H+ T ++ A+K + E + L+E+ IL+ Sbjct: 19 YEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILR 78 Query: 72 LLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKR 128 + H N++ L + T +LVFD + L + K TLSE ++ Sbjct: 79 KVSGHPNIIQLKDTYETNTF--------FFLVFDLMKK--GELFDYLTEKVTLSEKETRK 128 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 +M+ LL + +H+ I+HRD+K N+L+ D +KL DFG + P Sbjct: 129 IMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD------PGEKLRE 182 Query: 189 VV-TLWYRPPELLLGERD-----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 V T Y PE++ + YG +D+W G IM + SP + L +I Sbjct: 183 VCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM 242 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 W D+Y D +K DL+ + LV+ P + Sbjct: 243 SGNYQFGSPEW---DDY----------------SDTVK---------DLVSRFLVVQPQK 274 Query: 303 RIDSDDALNHDFF 315 R +++AL H FF Sbjct: 275 RYTAEEALAHPFF 287 >1BYG-A nrPDB Length = 278 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 100/213 (46%), Gaps = 39/213 (18%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L IG+G FG+V +R G KVA+K + + + F L E ++ L+H N+V L Sbjct: 26 LQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRHSNLVQL 79 Query: 82 IEICRTKASPYNRCKGSIYLVFDFC----------EHDLAGLLSNVLVKFTLSEIKRVMQ 131 + + + KG +Y+V ++ + L + L+KF+L Sbjct: 80 LGVIVEE-------KGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD------- 125 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + + Y+ N +HRD+ A NVL++ D V K++DFGL + S ++ T ++ Sbjct: 126 -VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPV 178 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 W P L E+ + D+W G ++ E+++ Sbjct: 179 KWTAPEALR--EKKFSTKSDVWSFGILLWEIYS 209 >4M7I-A nrPDB Length = 299 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 109/225 (48%), Gaps = 23/225 (10%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++ +E + +G+G FG VF+A+++ A+K++ + N +E +RE+K L L+H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEH 62 Query: 76 ENVVNL----IEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKR-- 128 +V +E T+ + K +Y+ C + +L ++ + T+ E +R Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNG---RCTIEERERSV 119 Query: 129 ---VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP--- 182 + + + ++H ++HRD+K +N+ T D V+K+ DFGL A + Q Sbjct: 120 CLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 183 -----NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 R+T +V T Y PE + G Y +D++ G I+ E+ Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQIHGN-SYSHKVDIFSLGLILFEL 223 >1PY5-A nrPDB Length = 326 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 66/232 (28%), Positives = 117/232 (50%), Gaps = 34/232 (14%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ--LLKHENVVNLI 82 IG+G FGEV++ + R G++VA+K E+ F RE +I Q +L+HEN++ I Sbjct: 37 IGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWF-----REAEIYQTVMLRHENILGFI 89 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLYY 139 + + ++LV D+ EH G L + L ++T++ ++ ++++ L+ GL + Sbjct: 90 AADNKDNGTWTQ----LWLVSDYHEH---GSLFDYLNRYTVT-VEGMIKLALSTASGLAH 141 Query: 140 IH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +H + I HRD+K+ N+L+ ++G +AD GLA A ++ +RV T Sbjct: 142 LHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGT 201 Query: 192 LWYRPPELL-----LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 Y PE+L + + D++ G + E+ R I G E +QL Sbjct: 202 KRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQL 252 >4L42-A nrPDB Length = 346 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 109/231 (47%), Gaps = 36/231 (15%) Query: 19 YEKLAKIGQGTFGEVFKARH---RKTGQ----KVALKKVLMENEKEGFPITALREIKILQ 71 +E L +G+G +G+VF+ R TG+ KV K +++ N K+ A R IL+ Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER--NILE 77 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFD-------FCEHDLAGLLSNVLVKFTLS 124 +KH +V+LI +T G +YL+ + F + + G+ F L+ Sbjct: 78 EVKHPFIVDLIYAFQTG--------GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA 129 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 EI L ++H+ I++RD+K N+++ G +KL DFGL + S+ + + Sbjct: 130 EISMA-------LGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHT 181 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 + T+ Y PE+L+ + +D W G +M +M T +P G + Sbjct: 182 FCG---TIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRK 228 >4E20-A nrPDB Length = 290 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 96/211 (45%), Gaps = 18/211 (8%) Query: 20 EKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +K+ +G+G FG+V + + TG+ VA+K L E REI+IL+ L H Sbjct: 11 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVK-ALKEGCGPQLRSGWQREIEILRTLYH 69 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIKRVMQML 133 E++V C + + S+ LV ++ G L + L + L+++ Q + Sbjct: 70 EHIVKYKGCCEDQG------EKSVQLVMEYVP---LGSLRDYLPRHCVGLAQLLLFAQQI 120 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+H +HR + A NVL+ D ++K+ DFGLA+A R W Sbjct: 121 CEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 180 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 Y P L E + D+W G + E+ T Sbjct: 181 YAPE--CLKECKFYYASDVWSFGVTLYELLT 209 >5YV8-A nrPDB Length = 298 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 113/247 (45%), Gaps = 44/247 (17%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE---KEGF---------- 59 C ++++Y +IG+G++G V A + A+K VL + + + GF Sbjct: 9 CVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMK-VLSKKKLIRQAGFPRRPPPRGTR 67 Query: 60 -----------PITAL-REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE 107 PI + +EI IL+ L H NVV L+E+ + +Y+VF+ Sbjct: 68 PAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDH------LYMVFELVN 121 Query: 108 HDLAGLLSNVLVKFTLSE--IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKL 165 G + V LSE + Q L+ G+ Y+H KI+HRD+K +N+L+ DG +K+ Sbjct: 122 Q---GPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKI 178 Query: 166 ADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY--GPPIDLWGAGCIM-AEM 222 ADFG++ F +N V T + PE L R G +D+W G + + Sbjct: 179 ADFGVSNEF----KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFV 234 Query: 223 WTRSPIM 229 + + P M Sbjct: 235 FGQCPFM 241 >6NT9-A nrPDB Length = 742 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 99/220 (45%), Gaps = 34/220 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLKHENVVNLIE 83 +GQG VF+ RH+KTG A+K + N P+ +RE ++L+ L H+N+V L Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 72 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGL 137 I + + L+ +FC G L VL + SE V++ ++ G+ Sbjct: 73 IEEETTTRHK------VLIMEFCP---CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 Query: 138 YYIHRNKILHRDMKAANVL--ITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ N I+HR++K N++ I DG V KL DFG AR ++ + T Sbjct: 124 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEE 178 Query: 194 YRPPELLL-------GERDYGPPIDLWGAGCIMAEMWTRS 226 Y P++ ++ YG +DLW G T S Sbjct: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 218 >3DAK-A nrPDB Length = 290 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 102/221 (46%), Gaps = 14/221 (6%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P+ YE IG G V A +KVA+K++ +E + L+EI+ + Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD-ELLKEIQAM 62 Query: 71 QLLKHENVVNLIEICRTKASPYNRCK----GSIYLVFDFCEHDLAG--LLSNVLVKFTLS 124 H N+V+ K + K GS V D +H +A S VL + T++ Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGS---VLDIIKHIVAKGEHKSGVLDESTIA 119 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 I R +L GL Y+H+N +HRD+KA N+L+ DG +++ADFG++ + + N+ Sbjct: 120 TILR---EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNK 176 Query: 185 YTNRVV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 V T + PE++ R Y D+W G E+ T Sbjct: 177 VRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT 217 >6DBN-A nrPDB Length = 316 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 97/211 (45%), Gaps = 16/211 (7%) Query: 20 EKLAKIGQGTFGEVFKARHR----KTGQKVALKKVLMENEKEGFPITALR-EIKILQLLK 74 +++ +G+G FG+V R+ TG++VA+K ++ E G I L+ EI+IL+ L Sbjct: 38 KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS--LKPESGGNHIADLKKEIEILRNLY 95 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVMQML 133 HEN+V IC I L+ +F L L K L + + + Sbjct: 96 HENIVKYKGICTEDGG------NGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQI 149 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ + +HRD+ A NVL+ + +K+ DFGL +A K + W Sbjct: 150 CKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFW 209 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 Y PE L+ + Y D+W G + E+ T Sbjct: 210 Y-APECLMQSKFYIAS-DVWSFGVTLHELLT 238 >4J52-A nrPDB Length = 293 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/305 (23%), Positives = 121/305 (39%), Gaps = 54/305 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKV-----LMENEKEGFPITALREIKILQLLKHENVV 79 +G+G F + F+ T + A K V L +++E + EI I + L H++VV Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM----EISIHRSLAHQHVV 77 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYY 139 + +++V + C L T E + ++ ++ G Y Sbjct: 78 GF--------HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQY 129 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 +HRN+++HRD+K N+ + D +K+ DFGLA R T Y PE Sbjct: 130 LHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEY----DGERKKVLCGTPNYIAPE- 184 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNY 259 +L ++ + +D+W GCIM + P + + + I + SI + Sbjct: 185 VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHI------- 237 Query: 260 ELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDP 319 +P A LI K+L DP R ++ LN +FF S Sbjct: 238 -------------------------NPVAASLIQKMLQTDPTARPTINELLNDEFFTSGY 272 Query: 320 MPSDL 324 +P+ L Sbjct: 273 IPARL 277 >4XCU-A nrPDB Length = 300 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 100/213 (46%), Gaps = 23/213 (10%) Query: 25 IGQGTFGEVFKARH------RKTGQKVALKKVLMENEKEGFPITALREIKILQLL-KHEN 77 +G+G FG+V +A R K+L +N + + E+++++L+ +H+N Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 84 Query: 78 VVNLIEICRTKASPY----NRCKGSI--YLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 ++NL+ +C + Y KG++ +L G LS ++ ++ R MQ Sbjct: 85 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQ 144 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 Y+ K +HRD+ A NVL+T D V+K+ADFGLAR + R+ Sbjct: 145 -------YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK-KTSNGRLPV 196 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 W P L +R Y D+W G ++ E++T Sbjct: 197 KWMAPEALF--DRVYTHQSDVWSFGILLWEIFT 227 >2PMN-X nrPDB Length = 348 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 81/332 (24%), Positives = 149/332 (44%), Gaps = 48/332 (14%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV---LMENEKEGFPITALREIKILQL 72 ++ Y + + QG F ++ K + ALKK L+E +++ T KI Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRD---FTKSNNDKISIK 84 Query: 73 LKHENVVNLIEICRTKASPYN-RCKG------SIYLVFDFCEHD--------LAGLLSNV 117 K+++ N ++I + Y C+G +Y+++++ E+D L N Sbjct: 85 SKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNY 144 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNK-ILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 + IK +++ +LN YIH K I HRD+K +N+L+ ++G +KL+DFG + + + Sbjct: 145 TCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESE-YMV 203 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDY-GPPIDLWGAG-CIMAEMWTRSPIMQGNTE 234 K + +R T + PPE E Y G +D+W G C+ + P Sbjct: 204 DKKIKGSR-----GTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF------ 252 Query: 235 QHQLALISQLCGSITPEV-WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLID 293 +++L+ T + +P N+ LY + +K + + +D + Sbjct: 253 SLKISLVELFNNIRTKNIEYPLDRNHFLYP----LTNKKSTCSNNFLS----NEDIDFLK 304 Query: 294 KLLVLDPAQRIDSDDALNHDFFWSDPMPSDLK 325 L +PA+RI S+DAL H++ +D DL+ Sbjct: 305 LFLRKNPAERITSEDALKHEWL-ADTNIEDLR 335 >4RLP-A nrPDB Length = 288 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 109/231 (47%), Gaps = 36/231 (15%) Query: 19 YEKLAKIGQGTFGEVFKARH---RKTGQ----KVALKKVLMENEKEGFPITALREIKILQ 71 +E L +G+G +G+VF+ R TG+ KV K +++ N K+ A R I L+ Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI--LE 64 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFD-------FCEHDLAGLLSNVLVKFTLS 124 +KH +V+LI +T G +YL+ + F + + G+ F L+ Sbjct: 65 EVKHPFIVDLIYAFQTG--------GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA 116 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 EI L ++H+ I++RD+K N+++ G +KL DFGL + S+ + + Sbjct: 117 EISMA-------LGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHT 168 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 + T+ Y PE+L+ + +D W G +M +M T +P G + Sbjct: 169 FCG---TIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRK 215 >6O8B-A nrPDB Length = 665 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 98/220 (44%), Gaps = 34/220 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLKHENVVNLIE 83 +GQG VF+ RH+KTG A+K + N P+ +RE ++L+ L H+N+V L Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 80 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGL 137 I + + L+ +FC G L VL + SE V++ ++ G+ Sbjct: 81 IEEETTTRHK------VLIMEFCP---CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 138 YYIHRNKILHRDMKAANVL--ITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ N I+HR++K N++ I DG V KL DFG AR ++ T Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVELYGTEE 186 Query: 194 YRPPELLL-------GERDYGPPIDLWGAGCIMAEMWTRS 226 Y P++ ++ YG +DLW G T S Sbjct: 187 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 226 >2OU7-A nrPDB Length = 335 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/305 (23%), Positives = 121/305 (39%), Gaps = 54/305 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKV-----LMENEKEGFPITALREIKILQLLKHENVV 79 +G+G F + F+ T + A K V L +++E + EI I + L H++VV Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM----EISIHRSLAHQHVV 104 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYY 139 + +++V + C L T E + ++ ++ G Y Sbjct: 105 GF--------HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQY 156 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 +HRN+++HRD+K N+ + D +K+ DFGLA R T Y PE Sbjct: 157 LHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDG----ERKKVLCGTPNYIAPE- 211 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNY 259 +L ++ + +D+W GCIM + P + + + I + SI + Sbjct: 212 VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHI------- 264 Query: 260 ELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDP 319 +P A LI K+L DP R ++ LN +FF S Sbjct: 265 -------------------------NPVAASLIQKMLQTDPTARPTINELLNDEFFTSGY 299 Query: 320 MPSDL 324 +P+ L Sbjct: 300 IPARL 304 >4C59-A nrPDB Length = 340 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 97/210 (46%), Gaps = 17/210 (8%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVNLIE 83 + +G F V++A+ +G++ ALK++L E++ I ++E+ ++ L H N+V Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAI--IQEVCFMKKLSGHPNIVQFCS 92 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLLNGLYYIH 141 + + L+ + C+ L L + + LS + ++ + ++H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 142 RNK--ILHRDMKAANVLITRDGVLKLADFGLAR--------AFSLAKNSQPNRYTNRVVT 191 R K I+HRD+K N+L++ G +KL DFG A ++S + + R T Sbjct: 153 RQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT 212 Query: 192 LWYRPPEL--LLGERDYGPPIDLWGAGCIM 219 YR PE+ L G D+W GCI+ Sbjct: 213 PMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >4OLI-A nrPDB Length = 645 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 100/214 (46%), Gaps = 24/214 (11%) Query: 20 EKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLME---NEKEGFPITALREIKILQL 72 +K+ +G+G FG+V + + TG+ VA+K + + + G+ +EI IL+ Sbjct: 356 KKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWK----QEIDILRT 411 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIKRVM 130 L HE+++ C + + S+ LV ++ G L + L + + L+++ Sbjct: 412 LYHEHIIKYKGCCEDQG------EKSLQLVMEYVP---LGSLRDYLPRHSIGLAQLLLFA 462 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q + G+ Y+H +HR++ A NVL+ D ++K+ DFGLA+A R Sbjct: 463 QQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 522 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 WY P L E + D+W G + E+ T Sbjct: 523 VFWYAPE--CLKEYKFYYASDVWSFGVTLYELLT 554 Score = 34.3 bits (77), Expect = 0.093, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 22/132 (16%) Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-------LKLADFGLARAFSLAKNSQ 181 V Q L + L Y+ ++H ++ N+L+ R G+ +KL+D G+ +L++ + Sbjct: 172 VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLG-ALSREER 230 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAE--------MWTRSPIMQGNT 233 R W P L G +D WG G + E + +RSP + + Sbjct: 231 VERIP------WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHF 284 Query: 234 EQHQLALISQLC 245 Q Q L C Sbjct: 285 YQRQHRLPEPSC 296 >2XIK-A nrPDB Length = 294 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 105/216 (48%), Gaps = 29/216 (13%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + KL +IG+G+FGEV+K T + VA+K + +E ++ ++ + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAED-------------EIEDIQQE 67 Query: 79 VNLIEICRTKASPY-NRCKGSIYL----VFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQ 131 + ++ C SPY R GS YL ++ E+ G ++L L E I +++ Sbjct: 68 ITVLSQCD---SPYITRYFGS-YLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILR 123 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L GL Y+H + +HRD+KAANVL++ G +KLADFG+A + ++Q R T Sbjct: 124 EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLT---DTQIKRNTFVGTP 180 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 W P ++ + Y D+W G E+ P Sbjct: 181 FWMAPE--VIKQSAYDFKADIWSLGITAIELAKGEP 214 >4EUT-A nrPDB Length = 396 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 99/220 (45%), Gaps = 34/220 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLKHENVVNLIE 83 +GQG VF+ RH+KTG A+K + N P+ +RE ++L+ L H+N+V L Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGL 137 I + + L+ +FC G L VL + SE V++ ++ G+ Sbjct: 75 IEEETTTRHK------VLIMEFCP---CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 138 YYIHRNKILHRDMKAANVL--ITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ N I+HR++K N++ I DG V KL DFG AR ++ + T Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEE 180 Query: 194 YRPPELLL-------GERDYGPPIDLWGAGCIMAEMWTRS 226 Y P++ ++ YG +DLW G T S Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 220 >3QA8-A nrPDB Length = 676 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 104/214 (48%), Gaps = 19/214 (8%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E ++G G FG V + H+ TG++VA+K+ E + L EI+I++ L H NV Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNV 74 Query: 79 VNLIEI--CRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE--IKRVMQML 133 V+ E+ K +P + L ++CE DL L+ L E I+ ++ + Sbjct: 75 VSAREVPDGLQKLAPND----LPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDI 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + L Y+H N+I+HRD+K N+++ + + K+ D G A+ Q T V Sbjct: 131 SSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKEL-----DQGELCTEFVG 185 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 TL Y PE LL ++ Y +D W G + E T Sbjct: 186 TLQYLAPE-LLEQKKYTVTVDYWSFGTLAFECIT 218 >4EUU-A nrPDB Length = 319 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 99/220 (45%), Gaps = 34/220 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLKHENVVNLIE 83 +GQG VF+ RH+KTG A+K + N P+ +RE ++L+ L H+N+V L Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIK--VFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFA 74 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGL 137 I + + L+ +FC G L VL + SE V++ ++ G+ Sbjct: 75 IEEETTTRHK------VLIMEFCP---CGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 138 YYIHRNKILHRDMKAANVL--ITRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ N I+HR++K N++ I DG V KL DFG AR ++ + T Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEE 180 Query: 194 YRPPELLL-------GERDYGPPIDLWGAGCIMAEMWTRS 226 Y P++ ++ YG +DLW G T S Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGS 220 >5FG8-A nrPDB Length = 285 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 77/305 (25%), Positives = 133/305 (43%), Gaps = 60/305 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL------REIKILQL 72 Y+ ++G+G F V + + TG + A K + N K+ +TA RE +I + Sbjct: 16 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKII---NTKK---LTARDFQKLEREARICRK 69 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVM 130 L H N+V L + + Y+ YLVFD L +++ + ++ ++ + Sbjct: 70 LHHPNIVRLHD--SIQEENYH------YLVFDLVTG--GELFEDIVAREFYSEADASHCI 119 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 Q +L + + H+N ++HRD+K N+L+ + +KLADFGLA + + Sbjct: 120 QQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLA----IEVQGDHQAWFG 175 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T Y PE+L E YG +D+W G I+ + P + +QH+ L SQ+ Sbjct: 176 FAGTPGYLSPEVLKKE-PYGKSVDIWACGVILYILLVGYPPFW-DEDQHR--LYSQIKAG 231 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 P D P A +LI+++L ++P +RI + Sbjct: 232 AYDYPSPEWDTV-------------------------TPEAKNLINQMLTVNPNKRITAA 266 Query: 308 DALNH 312 +AL H Sbjct: 267 EALKH 271 >2JC6-A nrPDB Length = 334 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 24/200 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G F EV A + TG+ A+K + + K G + EI +L+ +KHEN+V L +I Sbjct: 30 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALK-GKESSIENEIAVLRKIKHENIVALEDI 88 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYYIH 141 SP +YLV G L + +V+ +T + +++ +L+ +YY+H Sbjct: 89 YE---SP-----NHLYLVMQLVS---GGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLH 137 Query: 142 RNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 R I+HRD+K N+L + + ++DFGL++ + + + T Y PE Sbjct: 138 RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-----EGKGDVMSTACGTPGYVAPE 192 Query: 199 LLLGERDYGPPIDLWGAGCI 218 +L ++ Y +D W G I Sbjct: 193 -VLAQKPYSKAVDCWSIGVI 211 >5JZN-A nrPDB Length = 280 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 68/248 (27%), Positives = 113/248 (45%), Gaps = 25/248 (10%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +Y+ IG G F V + R T ++ ALK ++ +++ G E+ IL+ +KH N Sbjct: 20 RYKVGRTIGDGNFAVVKECVERSTAREYALK-IIKKSKCRGKEHMIQNEVSILRRVKHPN 78 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V LIE +YLV + + DL +++ K+T + ++ L + Sbjct: 79 IVLLIEEMDVPTE--------LYLVMELVKGGDLFDAITST-NKYTERDASGMLYNLASA 129 Query: 137 LYYIHRNKILHRDMKAANVLI--TRDG--VLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + Y+H I+HRD+K N+L+ +DG LKL DFGLA + T Sbjct: 130 IKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPT------ 183 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT--P 250 Y PE ++ E YG +D+W AG I + P +G+ + ++ L G + Sbjct: 184 -YVAPE-IIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPS 241 Query: 251 EVWPNVDN 258 W NV + Sbjct: 242 PYWDNVSD 249 >4XI2-A nrPDB Length = 446 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 101/211 (47%), Gaps = 31/211 (14%) Query: 22 LAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 L ++G G FG V + R GQ VA+K + + E + E K++ L HE +V Sbjct: 192 LKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSED---EFIEEAKVMMNLSHEKLVQ 246 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV----KFTLSEIKRVMQMLLNG 136 L +C TK P +F E+ G L N L +F ++ + + + Sbjct: 247 LYGVC-TKQRP----------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 295 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW--- 193 + Y+ + LHRD+ A N L+ GV+K++DFGL+R + YT+ V + + Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV------LDDEYTSSVGSKFPVR 349 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + PPE+L+ + + D+W G +M E+++ Sbjct: 350 WSPPEVLMYSK-FSSKSDIWAFGVLMWEIYS 379 >5MJB-A nrPDB Length = 305 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 102/209 (48%), Gaps = 27/209 (12%) Query: 25 IGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQLLKHENV 78 IG G FGEV+K R + G++ VA+K + E ++ F L E I+ H N+ Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDF----LSEASIMGQFDHRNI 89 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + L E TK+ P + ++ +F E+ L L +FT+ ++ +++ + G+ Sbjct: 90 IRL-EGVVTKSRP-------VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN----RVVTLW 193 Y+ +HRD+ A N+L+ + V K++DFGL+R L ++ YT+ ++ W Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR--YLQDDTSDPTYTSSLGGKIPVRW 199 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEM 222 P + R + D+W G +M E+ Sbjct: 200 TAPEA--IAYRKFTSASDVWSYGIVMWEV 226 >5IG1-A nrPDB Length = 344 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 25/219 (11%) Query: 9 ECPFCD--EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 E F D +V +K + IG+G F V + +++TG+ A+K + +++ + RE Sbjct: 7 ETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKRE 66 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTL 123 I I L+HE++V++ R ++ YLVF++ G L + +V + Sbjct: 67 IGICSSLQHEHIVSMRRAFRDES--------HFYLVFEYVS---GGELFDEIVTRKFYNE 115 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNS 180 + M +L+ L + H I+HRD+K N+L+ + +K+ DFGLA Sbjct: 116 KDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIM-----E 170 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 Q Y T Y PE++ Y +D+W G I+ Sbjct: 171 QGPTYFGFAGTPGYLSPEVIR-RVPYDTAVDVWACGVIL 208 >6E4F-A nrPDB Length = 290 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 35/213 (16%) Query: 22 LAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGF--PITALREIKILQLLKHENV 78 L ++G G FG V + R GQ VA+K + KEG + E K++ L HE + Sbjct: 36 LKELGTGQFGVVKYGKWR--GQYDVAIKMI-----KEGSMSEDEFIEEAKVMMNLSHEKL 88 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV----KFTLSEIKRVMQMLL 134 V L +C TK P +F E+ G L N L +F ++ + + + Sbjct: 89 VQLYGVC-TKQRP----------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVC 137 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW- 193 + Y+ + LHRD+ A N L+ GV+K++DFGL+R + YT+ V + + Sbjct: 138 EAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV------LDDEYTSSVGSKFP 191 Query: 194 --YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + PPE+L+ + + D+W G +M E+++ Sbjct: 192 VRWSPPEVLMYSK-FSSKSDIWAFGVLMWEIYS 223 >6CCF-A nrPDB Length = 290 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 50/159 (31%), Positives = 84/159 (52%), Gaps = 17/159 (10%) Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FT 122 +EI IL+ L H NVV LIE+ A + ++YLVFD G + V F+ Sbjct: 77 QEIAILKKLDHVNVVKLIEVLDDPA------EDNLYLVFDLLR---KGPVMEVPCDKPFS 127 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 + + ++ ++ GL Y+H KI+HRD+K +N+L+ DG +K+ADFG++ F ++Q Sbjct: 128 EEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE-GNDAQ- 185 Query: 183 NRYTNRVVTLWYRPPELL--LGERDYGPPIDLWGAGCIM 219 ++ T + PE + G+ G +D+W G + Sbjct: 186 --LSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTL 222 >4HVI-A nrPDB Length = 314 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 21/211 (9%) Query: 22 LAKIGQGTFGEVFKARHR----KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 ++++G+G FG V R+ TG VA+K++ + REI+IL+ L + Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ--REIQILKALHSDF 72 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL----VKFTLSEIKRVMQML 133 +V + + Y + S+ LV ++ +G L + L + S + + Sbjct: 73 IV------KYRGVSYGPGRQSLRLVMEYLP---SGCLRDFLQRHRARLDASRLLLYSSQI 123 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ + +HRD+ A N+L+ + +K+ADFGLA+ L K+ R + W Sbjct: 124 CKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFW 183 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 Y P L + + D+W G ++ E++T Sbjct: 184 YAPES--LSDNIFSRQSDVWSFGVVLYELFT 212 >2W4O-A nrPDB Length = 349 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 130/311 (41%), Gaps = 76/311 (24%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E +++G+G V++ + + T + ALK + +K+ EI +L L H N+ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK----IVRTEIGVLLRLSHPNI 110 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLN 135 + L EI T I LV + G L + +V+ ++ + ++ +L Sbjct: 111 IKLKEIFETPTE--------ISLVLELVT---GGELFDRIVEKGYYSERDAADAVKQILE 159 Query: 136 GLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVV-- 190 + Y+H N I+HRD+K N+L D LK+ADFGL++ ++ + V Sbjct: 160 AVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE-------HQVLMKTVCG 212 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE+L G YGP +D+W G I + LCG Sbjct: 213 TPGYCAPEILRG-CAYGPEVDMWSVGIITYIL---------------------LCG---- 246 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKA--YVRDPY-------ALDLIDKLLVLDPA 301 +E +G + + L Y P+ A DL+ KL+VLDP Sbjct: 247 -----------FEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPK 295 Query: 302 QRIDSDDALNH 312 +R+ + AL H Sbjct: 296 KRLTTFQALQH 306 >3FXW-A nrPDB Length = 336 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 100/219 (45%), Gaps = 28/219 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI-KILQLLKHENVVNLIE 83 +G G G+V + HR+TGQK ALK +L ++ K A +E+ Q ++V +++ Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALK-LLYDSPK------ARQEVDHHWQASGGPHIVCILD 89 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLNGLYY 139 + + K + ++ + E L S + + FT E +M+ + + + Sbjct: 90 VYEN----MHHGKRCLLIIMECMEG--GELFSRIQERGDQAFTEREAAEIMRDIGTAIQF 143 Query: 140 IHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 +H + I HRD+K N+L T +D VLKL DFG AK + N T +Y Sbjct: 144 LHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFG------FAKETTQNALQTPCYTPYYVA 197 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 PE +LG Y D+W G IM + P NT Q Sbjct: 198 PE-VLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQ 235 >2HK5-A nrPDB Length = 270 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 104/222 (46%), Gaps = 25/222 (11%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITAL 64 D+ E P E K EK K+G G FGEV+ A + K KVA+K + + E F L Sbjct: 8 DAWEIP--RESLKLEK--KLGAGQFGEVWMATYNKH-TKVAVKTMKPGSMSVEAF----L 58 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLVKFT 122 E +++ L+H+ +V L + K IY++ +F L L S+ K Sbjct: 59 AEANVMKTLQHDKLVKLHAVV---------TKEPIYIITEFMAKGSLLDFLKSDEGSKQP 109 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 L ++ + G+ +I + +HRD++AAN+L++ V K+ADFGLAR + N Sbjct: 110 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV--IEDNEYT 167 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 R + W P + G + D+W G ++ E+ T Sbjct: 168 AREGAKFPIKWTAPEAINFG--SFTIKSDVWSFGILLMEIVT 207 >3MV5-A nrPDB Length = 342 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 87/361 (24%), Positives = 165/361 (45%), Gaps = 73/361 (20%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK----KVLMENEKEGFPITALREIKILQ 71 ++++E L +G+GTFG+V + + TG+ A+K +V++ ++ +T E ++LQ Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT---ENRVLQ 65 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 +H + L +T ++R + V ++ +L LS V F+ + Sbjct: 66 NSRHPFLTALKYSFQT----HDR----LCFVMEYANGGELFFHLSRERV-FSEDRARFYG 116 Query: 131 QMLLNGLYYIHRNK-ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 +++ L Y+H K +++RD+K N+++ +DG +K+ DFGL + + + + Sbjct: 117 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE-GIKDGATMKTFCG-- 173 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T Y PE +L + DYG +D WG G +M EM +CG + Sbjct: 174 -TPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEM---------------------MCGRLP 210 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI----- 304 + N D+ +L+ EL+ ++ + L P A L+ LL DP QR+ Sbjct: 211 ---FYNQDHEKLF---ELILMEEIRFPRTL-----GPEAKSLLSGLLKKDPKQRLGGGSE 259 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTN 364 D+ + + H FF G++ H+ + L+PP + Q+T ++ + + T Sbjct: 260 DAKEIMQHRFF---------AGIVWQHVYE--KKLSPPFK--PQVTSETDTRYFDEEFTA 306 Query: 365 Q 365 Q Sbjct: 307 Q 307 >3Q4U-A nrPDB Length = 301 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 74/280 (26%), Positives = 124/280 (44%), Gaps = 40/280 (14%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L +G+G +GEV++ + G+ VA+K +EK F T L +L+HEN++ Sbjct: 13 LECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTV---MLRHENILGF 67 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVMQMLLNGLYY 139 I AS S L H++ G L + L TL + R++ + +GL + Sbjct: 68 I------ASDMTSRHSSTQLWLITHYHEM-GSLYDYLQLTTLDTVSCLRIVLSIASGLAH 120 Query: 140 IH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +H + I HRD+K+ N+L+ ++G +AD GLA S + N RV T Sbjct: 121 LHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGT 180 Query: 192 LWYRPPELL-----LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 Y PE+L + D +D+W G ++ E+ R + G E ++ Sbjct: 181 KRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV-ARRMVSNGIVEDYKPPFY----- 234 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP 286 +V PN ++E K+ V Q+ + +R + DP Sbjct: 235 ----DVVPNDPSFEDMRKVVCVDQQRPNIPNR---WFSDP 267 >5KCV-A nrPDB Length = 460 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 87/361 (24%), Positives = 165/361 (45%), Gaps = 73/361 (20%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK----KVLMENEKEGFPITALREIKILQ 71 ++++E L +G+GTFG+V + + TG+ A+K +V++ ++ +T E ++LQ Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLT---ENRVLQ 217 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 +H + L +T ++R + V ++ +L LS V F+ + Sbjct: 218 NSRHPFLTALKYSFQT----HDR----LCFVMEYANGGELFFHLSRERV-FSEDRARFYG 268 Query: 131 QMLLNGLYYIHRNK-ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 +++ L Y+H K +++RD+K N+++ +DG +K+ DFGL + + + + Sbjct: 269 AEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE-GIKDGATMKTFCG-- 325 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T Y PE +L + DYG +D WG G +M EM +CG + Sbjct: 326 -TPEYLAPE-VLEDNDYGRAVDWWGLGVVMYEM---------------------MCGRLP 362 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI----- 304 + N D+ +L+ EL+ ++ + L P A L+ LL DP QR+ Sbjct: 363 ---FYNQDHEKLF---ELILMEEIRFPRTL-----GPEAKSLLSGLLKKDPKQRLGGGSE 411 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTN 364 D+ + + H FF G++ H+ + L+PP + Q+T ++ + + T Sbjct: 412 DAKEIMQHRFF---------AGIVWQHVYE--KKLSPPFK--PQVTSETDTRYFDEEFTA 458 Query: 365 Q 365 Q Sbjct: 459 Q 459 >3ORZ-A nrPDB Length = 316 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 81/314 (25%), Positives = 123/314 (39%), Gaps = 69/314 (21%) Query: 21 KLAKI-GQGTFGEVFKARHRKTGQKVALKKVLMENE---KEGFPITALREIKILQLLKHE 76 K KI G+G+F V AR T ++ A+K ++E KE RE ++ L H Sbjct: 40 KFGKILGEGSFSTVVLARELATSREYAIK--ILEKRHIIKENKVPYVTRERDVMSRLDHP 97 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-------LAGLLSNVLVKFTLSEIKRV 129 V L C +Y + ++ G +F +EI Sbjct: 98 FFVKLY-FCFQDDE-------KLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEI--- 146 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 ++ L Y+H I+HRD+K N+L+ D +++ DFG A+ L+ S+ R + V Sbjct: 147 ----VSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV--LSPESKQARANSFV 200 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T Y PELL E+ DLW GCI+ ++ P + E I +L Sbjct: 201 GTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL----- 254 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 Y+ EK P A DL++KLLVLD +R+ ++ Sbjct: 255 --------EYDFPEKF-------------------FPKARDLVEKLLVLDATKRLGCEEM 287 Query: 310 LN------HDFFWS 317 H FF S Sbjct: 288 EGYGPLKAHPFFES 301 >2PSQ-A nrPDB Length = 370 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 105/227 (46%), Gaps = 42/227 (18%) Query: 25 IGQGTFGEVFKAR-------HRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-KHE 76 +G+G FG+V A K VA+K +L ++ E + E+++++++ KH+ Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVK-MLKDDATEKDLSDLVSEMEMMKMIGKHK 147 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL------------------ 118 N++NL+ C G +Y++ ++ G L L Sbjct: 148 NIINLLGACTQD--------GPLYVIVEYASK---GNLREYLRARRPPGMEYSYDINRVP 196 Query: 119 -VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 + T ++ L G+ Y+ K +HRD+ A NVL+T + V+K+ADFGLAR + Sbjct: 197 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 256 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + + TN + + + PE L +R Y D+W G +M E++T Sbjct: 257 DYYK--KTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFT 300 >4AN9-A nrPDB Length = 301 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 83/321 (25%), Positives = 133/321 (41%), Gaps = 62/321 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L + Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYI 69 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLN 135 V + Y+ + SI + EH G L VL K + +V ++ Sbjct: 70 VGFY------GAFYSDGEISICM-----EHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 118 Query: 136 GLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+ ++KI+HRD+K +N+L+ G +KL DFG++ + N + V T Y Sbjct: 119 GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---DEMANEF---VGTRSY 172 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEM----WTRSPIMQGNTEQHQLALISQLCGSITP 250 PE L G Y D+W G + EM + R P+ I +L I Sbjct: 173 MSPERLQGTH-YSVQSDIWSMGLSLVEMAVGRYPRPPMA-----------IFELLDYIVN 220 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E P +L + V D ++K L+ +PA+R D + Sbjct: 221 EPPP-----------------------KLPSAVFSLEFQDFVNKCLIKNPAERADLKQLM 257 Query: 311 NHDFF-WSDPMPSDLKGMLST 330 H F SD D G L + Sbjct: 258 VHAFIKRSDAEEVDFAGWLCS 278 >4XEY-B nrPDB Length = 408 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 110/230 (47%), Gaps = 29/230 (12%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGF 59 ++ YD E D K+ K+G G +GEV++ +K VA+K + + E E F Sbjct: 113 VSPNYDKWEMERTDITMKH----KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 168 Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 L+E +++ +KH N+V L+ +C T+ P+ Y++ +F + G L + L Sbjct: 169 ----LKEAAVMKEIKHPNLVQLLGVC-TREPPF-------YIITEFMTY---GNLLDYLR 213 Query: 120 KFTLSEIKRVMQMLL-----NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF 174 + E+ V+ + + + + Y+ + +HRD+ A N L+ + ++K+ADFGL+R Sbjct: 214 ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRL- 272 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + ++ + W P L + + D+W G ++ E+ T Sbjct: 273 -MTGDTYTAHAGAKFPIKWTAPESLAYNK--FSIKSDVWAFGVLLWEIAT 319 >4FG9-A nrPDB Length = 320 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 95/201 (47%), Gaps = 26/201 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G F EV A ++T + VA+K + E EG + EI +L +KH N+V L +I Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEA-LEGKEGSMENEIAVLHKIKHPNIVALDDI 84 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYYIH 141 + G +YL+ G L + +V+ +T + R++ +L+ + Y+H Sbjct: 85 YESG--------GHLYLIMQLVS---GGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH 133 Query: 142 RNKILHRDMKAANVL---ITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TLWYRPP 197 I+HRD+K N+L + D + ++DFG L+K P + T Y P Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFG------LSKMEDPGSVLSTACGTPGYVAP 187 Query: 198 ELLLGERDYGPPIDLWGAGCI 218 E +L ++ Y +D W G I Sbjct: 188 E-VLAQKPYSKAVDCWSIGVI 207 >3ORP-A nrPDB Length = 311 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 17/222 (7%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE-GFPITALREIKILQLLKHE 76 +YE +G G EV AR + + VA+K + + ++ F + RE + L H Sbjct: 13 RYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHP 72 Query: 77 NVVNLIEI--CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 +V + + T A P Y+V ++ + L +++ KR ++++ Sbjct: 73 AIVAVYDTGEAETPAGPLP------YIVMEYVD---GVTLRDIVHTEGPMTPKRAIEVIA 123 Query: 135 NG---LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + L + H+N I+HRD+K AN++I+ +K+ DFG+ARA + + NS + + T Sbjct: 124 DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSV-TQTAAVIGT 182 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNT 233 Y PE G+ D++ GC++ E+ T P G++ Sbjct: 183 AQYLSPEQARGD-SVDARSDVYSLGCVLYEVLTGEPPFTGDS 223 >4TNB-A nrPDB Length = 590 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 99/214 (46%), Gaps = 17/214 (7%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G FGEV + R TG+ A K++ + +K AL E +IL+ + + VVNL Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVL-VKFTLSEIKRVMQMLLNGLYYIH 141 TK ++ LV DL + N+ F +L GL +H Sbjct: 252 AYETK--------DALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 ++RD+K N+L+ G ++++D GLA K + + RV T+ Y PE+L Sbjct: 304 HENTVYRDLKPENILLDDYGHIRISDLGLA-----VKIPEGDLIRGRVGTVGYMAPEVLN 358 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 +R YG D WG GC++ EM +G E+ Sbjct: 359 NQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK 391 >4GS6-A nrPDB Length = 315 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 98/211 (46%), Gaps = 37/211 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G+G FG V KA+ R + VA+K++ E+E++ F + E++ L + H N+V L Sbjct: 17 VGRGAFGVVCKAKWR--AKDVAIKQIESESERKAF----IVELRQLSRVNHPNIVKL--- 67 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQMLLNGLY 138 Y C + LV ++ E G L NVL +T + G+ Sbjct: 68 -------YGACLNPVCLVMEYAE---GGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 139 YIHR---NKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Y+H ++HRD+K N+L+ G VLK+ DFG A + Q + N+ W Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFG------TACDIQTHMTNNKGSAAWM 171 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTR 225 PE+ G +Y D++ G I+ E+ TR Sbjct: 172 A-PEVFEGS-NYSEKCDVFSWGIILWEVITR 200 >3CJF-A nrPDB Length = 309 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 103/217 (47%), Gaps = 27/217 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR----EIKIL-QLLKHENVV 79 +G+G FG+V +A + + V ++ KEG + R E+KIL + H NVV Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 94 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKF-----------TLSEIK 127 NL+ C P + ++ +FC+ +L+ L + +F TL + Sbjct: 95 NLLGACTKPGGP-------LMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLI 147 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 + G+ ++ K +HRD+ A N+L++ V+K+ DFGLAR + K+ R + Sbjct: 148 CYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR--DIYKDPDYVRKGD 205 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + L + PE + +R Y D+W G ++ E+++ Sbjct: 206 ARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFS 241 >2VWV-A nrPDB Length = 302 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 103/211 (48%), Gaps = 31/211 (14%) Query: 25 IGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQLLKHENV 78 IG G FGEV + R + G+K VA+K + E ++ F L E I+ +H N+ Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREF----LSEASIMGQFEHPNI 79 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL----VKFTLSEIKRVMQMLL 134 + L E T + P + ++ +F E+ G L + L +FT+ ++ +++ + Sbjct: 80 IRL-EGVVTNSMP-------VMILTEFMEN---GALDSFLRLNDGQFTVIQLVGMLRGIA 128 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN---RVVT 191 +G+ Y+ +HRD+ A N+L+ + V K++DFGL+R F +S P ++ ++ Sbjct: 129 SGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSR-FLEENSSDPTETSSLGGKIPI 187 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 W P + R + D W G +M E+ Sbjct: 188 RWTAPEAIAF--RKFTSASDAWSYGIVMWEV 216 >5LPZ-A nrPDB Length = 332 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 104/210 (49%), Gaps = 27/210 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 IG G FG+V+KA K G VA+KK++ + + A E++ + +KH N+V L+ Sbjct: 25 IGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMA--EMETIGKIKHRNLVPLLGY 81 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-------VKFTLSEIKRVMQMLLNGL 137 C+ LV++F ++ G L +VL VK S +++ GL Sbjct: 82 CKVGDERL--------LVYEFMKY---GSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGL 130 Query: 138 YYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 ++H N I+HRDMK++NVL+ + +++DFG+AR S A ++ + T T Y Sbjct: 131 AFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMS-AMDTHLSVST-LAGTPGY 188 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 PPE R D++ G ++ E+ T Sbjct: 189 VPPEYYQSFR-CSTKGDVYSYGVVLLELLT 217 >6NPU-A nrPDB Length = 298 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 108/226 (47%), Gaps = 29/226 (12%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITA 63 YD E D K+ K+G G +GEV++ +K VA+K + + E E F Sbjct: 18 YDKWEMERTDITMKH----KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF---- 69 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL 123 L+E +++ +KH N+V L+ +C T+ P+ Y++ +F + G L + L + Sbjct: 70 LKEAAVMKEIKHPNLVQLLGVC-TREPPF-------YIITEFMTY---GNLLDYLRECNR 118 Query: 124 SEIKRVMQMLL-----NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 E+ V+ + + + + Y+ + +HRD+ A N L+ + ++K+ADFGL+R + Sbjct: 119 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRL--MTG 176 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 ++ + W P L + + D+W G ++ E+ T Sbjct: 177 DTYTAHAGAKFPIKWTAPESLAYNK--FSIKSDVWAFGVLLWEIAT 220 >5LPV-A nrPDB Length = 296 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 104/210 (49%), Gaps = 27/210 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 IG G FG+V+KA K G VA+KK++ + + A E++ + +KH N+V L+ Sbjct: 25 IGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMA--EMETIGKIKHRNLVPLLGY 81 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-------VKFTLSEIKRVMQMLLNGL 137 C+ LV++F ++ G L +VL VK S +++ GL Sbjct: 82 CKVGDERL--------LVYEFMKY---GSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGL 130 Query: 138 YYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 ++H N I+HRDMK++NVL+ + +++DFG+AR S A ++ + T T Y Sbjct: 131 AFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMS-AMDTHLSVST-LAGTPGY 188 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 PPE R D++ G ++ E+ T Sbjct: 189 VPPEYYQSFR-CSTKGDVYSYGVVLLELLT 217 >4G3E-A nrPDB Length = 352 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 67/248 (27%), Positives = 110/248 (44%), Gaps = 45/248 (18%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 + ++ V+ + +EV ++G+G+FGEV + + ++TG + A+KKV +E Sbjct: 58 LTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLE------- 110 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 + + E+ L +V L R P+ V F E G L ++ + Sbjct: 111 VFRVEELVACAGLSSPRIVPLYGAVRE--GPW---------VNIFMELLEGGSLGQLIKQ 159 Query: 121 FTLSEIKRVMQML---LNGLYYIHRNKILHRDMKAANVLITRDGV-LKLADFGLARAFSL 176 R + L L GL Y+H +ILH D+KA NVL++ DG L DFG A Sbjct: 160 MGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCL-- 217 Query: 177 AKNSQPNRYTNRVVTLWYRP-------PELLLGERDYGPPIDLWGAGCIMAEM------W 223 QP+ ++T Y P PE+++G + +D+W + C+M M W Sbjct: 218 ----QPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNGCHPW 272 Query: 224 T---RSPI 228 T R P+ Sbjct: 273 TQYFRGPL 280 >3QGY-A nrPDB Length = 286 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 97/209 (46%), Gaps = 23/209 (11%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 +IG G FG V + KVA+K + + E + E +++ L H +V L Sbjct: 34 EIGSGQFGLVHLG-YWLNKDKVAIKTIKEGSMSED---DFIEEAEVMMKLSHPKLVQLYG 89 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-VKFTLSEIKRVMQMLLN---GLYY 139 +C +A I LVF+F EH G LS+ L + L + ++ M L+ G+ Y Sbjct: 90 VCLEQAP--------ICLVFEFMEH---GCLSDYLRTQRGLFAAETLLGMCLDVCEGMAY 138 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + ++HRD+ A N L+ + V+K++DFG+ R + Q T + + PE+ Sbjct: 139 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTR---FVLDDQYTSSTGTKFPVKWASPEV 195 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 R Y D+W G +M E+++ I Sbjct: 196 FSFSR-YSSKSDVWSFGVLMWEVFSEGKI 223 >1U59-A nrPDB Length = 287 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 91/204 (44%), Gaps = 21/204 (10%) Query: 24 KIGQGTFGEVFKA--RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 ++G G FG V + R RK VA+K VL + ++ +RE +I+ L + +V L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 75 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV----KFTLSEIKRVMQMLLNGL 137 I +C+ +A + LV + G L LV + +S + ++ + G+ Sbjct: 76 IGVCQAEA---------LMLVMEMAG---GGPLHKFLVGKREEIPVSNVAELLHQVSMGM 123 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ +HRD+ A NVL+ K++DFGL++A + R + WY P Sbjct: 124 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 183 Query: 198 ELLLGERDYGPPIDLWGAGCIMAE 221 + R + D+W G M E Sbjct: 184 --CINFRKFSSRSDVWSYGVTMWE 205 >5L6P-A nrPDB Length = 298 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 113/232 (48%), Gaps = 34/232 (14%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKV---LMEN 54 AK+ D V C +EV IG G FGEV + R ++ G++ VA+K + E Sbjct: 12 FAKEID-VSCVKIEEV--------IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTER 62 Query: 55 EKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGL 113 ++ F L E I+ H N++ L E TK+ P + ++ +F E+ L Sbjct: 63 QRRDF----LSEASIMGQFDHPNIIRL-EGVVTKSRP-------VMILTEFMENCALDSF 110 Query: 114 LSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA 173 L +FT+ ++ +++ + G+ Y+ +HRD+ A N+L+ + V K++DFGL+R Sbjct: 111 LRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR- 169 Query: 174 FSLAKNSQPNRYTNRV---VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 F S P YT+ + + + + PE + R + D+W G +M E+ Sbjct: 170 FLEDDPSDPT-YTSSLGGKIPIRWTAPE-AIAYRKFTSASDVWSYGIVMWEV 219 >2R2P-A nrPDB Length = 295 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 97/208 (46%), Gaps = 27/208 (12%) Query: 25 IGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQLLKHENV 78 IG G FGEV R + G++ VA+K + E ++ F L E I+ H N+ Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDF----LGEASIMGQFDHPNI 85 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLL 134 ++L E TK+ P + +V ++ E+ G L L K FT+ ++ +++ + Sbjct: 86 IHL-EGVVTKSKP-------VMIVTEYMEN---GSLDTFLKKNDGQFTVIQLVGMLRGIS 134 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+ +HRD+ A N+LI + V K++DFGL+R + ++ W Sbjct: 135 AGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 194 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEM 222 P + R + D+W G +M E+ Sbjct: 195 APEAIAF--RKFTSASDVWSYGIVMWEV 220 >3DKO-A nrPDB Length = 318 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 95/205 (46%), Gaps = 21/205 (10%) Query: 25 IGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQLLKHENV 78 IG G FGEV R + G++ VA+K + E ++ F L E I+ H NV Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDF----LCEASIMGQFDHPNV 106 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V+L E T+ P + +V +F E+ L L +FT+ ++ +++ + G+ Sbjct: 107 VHL-EGVVTRGKP-------VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 158 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ +HRD+ A N+L+ + V K++DFGL+R + ++ W P Sbjct: 159 RYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 218 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEM 222 + R + D+W G +M E+ Sbjct: 219 AIQY--RKFTSASDVWSYGIVMWEV 241 >6HV0-A nrPDB Length = 416 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 72/301 (23%), Positives = 127/301 (42%), Gaps = 51/301 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHENVVNLIE 83 +G G G + R + VA+K++L E F A RE+++L + +H NV+ Sbjct: 16 LGHGAEGTIV-YRGMFDNRDVAVKRIL----PECFSF-ADREVQLLRESDEHPNVIRYF- 68 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 C K + Y+ + C L + E ++Q +GL ++H Sbjct: 69 -CTEKDRQFQ------YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSL 121 Query: 144 KILHRDMKAANVLIT---RDGVLK--LADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 I+HRD+K N+LI+ G +K ++DFGL + ++ ++S R W PE Sbjct: 122 NIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWI-APE 180 Query: 199 LLLGERDYGP--PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 +L + P +D++ AGC+ + + G + Q Q ++ C Sbjct: 181 MLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACS---------- 230 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 L+ + +K + D A +LI+K++ +DP +R + L H FFW Sbjct: 231 --------LDCLHPEKHE----------DVIARELIEKMIAMDPQKRPSAKHVLKHPFFW 272 Query: 317 S 317 S Sbjct: 273 S 273 >5EG3-A nrPDB Length = 334 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 106/224 (47%), Gaps = 36/224 (16%) Query: 25 IGQGTFGEVFKAR-------HRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-KHE 76 +G+G FG+V A K VA+K +L ++ E + E+++++++ KH+ Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVK-MLKDDATEKDLSDLVSEMEMMKMIGKHK 101 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH---------------DLAGLLSNVLV-K 120 N++NL+ C G +Y++ + +L+ ++ V + Sbjct: 102 NIINLLGACTQD--------GPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 T ++ L G+ Y+ K +HRD+ A NVL+T + V+K+ADFGLAR + Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFF 213 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + TN + + + PE L +R Y D+W G +M E++T Sbjct: 214 K--ETTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFT 254 >3DLS-A nrPDB Length = 335 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 97/213 (45%), Gaps = 28/213 (13%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVL----MENEKEGFPITALREIK 68 KY ++ +G G FG V+ A ++ ++V +K KVL +E+ K G EI Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLG---KVTLEIA 81 Query: 69 ILQLLKHENVVNLIEICRTKA--SPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI 126 IL ++H N++ +++I + GS +F F D L L + Sbjct: 82 ILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFI--DRHPRLDEPLASY----- 134 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + + L++ + Y+ I+HRD+K N++I D +KL DFG A K + Sbjct: 135 --IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGK-----LFY 187 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 T+ Y PE+L+G GP +++W G + Sbjct: 188 TFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTL 220 >2PL0-A nrPDB Length = 289 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 125/275 (45%), Gaps = 37/275 (13%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVV 79 + ++G G FGEV+ + KVA+K + K+G P L E +++ L+H+ +V Sbjct: 28 VERLGAGQFGEVWMGYYNGH-TKVAVKSL-----KQGSMSPDAFLAEANLMKQLQHQRLV 81 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL-----VKFTLSEIKRVMQMLL 134 L + + IY++ ++ E+ G L + L +K T++++ + + Sbjct: 82 RLYAVV---------TQEPIYIITEYMEN---GSLVDFLKTPSGIKLTINKLLDMAAQIA 129 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ +I +HRD++AAN+L++ K+ADFGLAR + N R + W Sbjct: 130 EGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARL--IEDNEYTAREGAKFPIKWT 187 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI-MQGNTEQHQLALISQLCGSITPEVW 253 P + G + D+W G ++ E+ T I G T + + + + P+ Sbjct: 188 APEAINYG--TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 245 Query: 254 PNVDNYELYEKLELV---KGQKRKVKDRLKAYVRD 285 P ELY+ + L + + R D L++ + D Sbjct: 246 PE----ELYQLMRLCWKERPEDRPTFDYLRSVLED 276 >2FO0-A nrPDB Length = 495 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 110/230 (47%), Gaps = 29/230 (12%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGF 59 ++ YD E D K+ K+G G +GEV++ +K VA+K + + E E F Sbjct: 205 VSPNYDKWEMERTDITMKH----KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEF 260 Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 L+E +++ +KH N+V L+ +C T+ P+ Y++ +F + G L + L Sbjct: 261 ----LKEAAVMKEIKHPNLVQLLGVC-TREPPF-------YIITEFMTY---GNLLDYLR 305 Query: 120 KFTLSEIKRVMQMLL-----NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF 174 + E+ V+ + + + + Y+ + +HR++ A N L+ + ++K+ADFGL+R Sbjct: 306 ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRL- 364 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + ++ + W P L + + D+W G ++ E+ T Sbjct: 365 -MTGDTYTAHAGAKFPIKWTAPESLAYNK--FSIKSDVWAFGVLLWEIAT 411 >5VD3-A nrPDB Length = 311 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 93/221 (42%), Gaps = 14/221 (6%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +++L+++G G++GEVFK R ++ G+ A+K+ + F R K+ ++ HE Sbjct: 58 SFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSP-----FRGPKDRARKLAEVGSHEK 112 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V C + G +YL + C L +++ ++ L L Sbjct: 113 VGQ--HPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLAL 170 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 ++H ++H D+K AN+ + G KL DFGL A + R Y P Sbjct: 171 AHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPR-----YMAP 225 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 ELL G YG D++ G + E+ + G QL Sbjct: 226 ELLQG--SYGTAADVFSLGLTILEVACNMELPHGGEGWQQL 264 >3TXO-A nrPDB Length = 353 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 97/213 (45%), Gaps = 23/213 (10%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQ----KVALKKVLMENEKEGFPITALREIKILQ 71 + +E + +G+G+FG+V AR ++TG KV K V+++++ +T E +IL Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT---EKRILS 78 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 L ++ + + C ++ V +F +F + + Sbjct: 79 LARNHPFLTQLFCCFQTPD-------RLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 131 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV- 190 +++ L ++H I++RD+K NVL+ +G KLADFG + K N T Sbjct: 132 EIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFG------MCKEGICNGVTTATFC 185 Query: 191 -TLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 T Y PE +L E YGP +D W G ++ EM Sbjct: 186 GTPDYIAPE-ILQEMLYGPAVDWWAMGVLLYEM 217 >4K33-A nrPDB Length = 325 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 102/226 (45%), Gaps = 40/226 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALK------KVLMENEKEGFPITALREIKILQLL-KHEN 77 +G+G FG+V A + A K K+L ++ + + E+++++++ KH+N Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 103 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL------------------- 118 ++NL+ C T+ P ++ E+ G L L Sbjct: 104 IINLLGAC-TQGGP----------LYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPE 152 Query: 119 VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + T ++ + G+ Y+ K +HRD+ A NVL+T D V+K+ADFGLAR + Sbjct: 153 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR--DVHN 210 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 TN + + + PE L +R Y D+W G ++ E++T Sbjct: 211 LDYYKETTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLLWEIFT 255 >5A46-A nrPDB Length = 386 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 110/225 (48%), Gaps = 38/225 (16%) Query: 25 IGQGTFGEVFKAR---------HRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-K 74 +G+G FG+V A +R T KVA+K +L + E + E+++++++ K Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVT--KVAVK-MLKSDATEKDLSDLISEMEMMKMIGK 104 Query: 75 HENVVNLIEICRTKASPY----NRCKGSI--YLV------FDFC---EHDLAGLLSNVLV 119 H+N++NL+ C Y KG++ YL ++C H+ LS+ + Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 ++ R G+ Y+ K +HRD+ A NVL+T D V+K+ADFGLAR Sbjct: 165 VSCAYQVAR-------GMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 217 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + + TN + + + PE L +R Y D+W G ++ E++T Sbjct: 218 YK--KTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFT 259 >4Y93-A nrPDB Length = 446 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 96/208 (46%), Gaps = 25/208 (12%) Query: 22 LAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 L ++G G FG V + R GQ VA+K + + E + E K++ L HE +V Sbjct: 193 LKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSED---EFIEEAKVMMNLSHEKLVQ 247 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV----KFTLSEIKRVMQMLLNG 136 L +C TK P +F E+ G L N L +F ++ + + + Sbjct: 248 LYGVC-TKQRP----------IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 296 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 + Y+ + LHRD+ A N L+ GV+K++DFG+ R + + T + + Sbjct: 297 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTR---YVLDDEYTSSTGSKFPVKWAS 353 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWT 224 PE+L+ + + D+W G +M E+++ Sbjct: 354 PEVLMYSK-FSSKSDIWAFGVLMWEIYS 380 >3GQL-A nrPDB Length = 326 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 64/225 (28%), Positives = 110/225 (48%), Gaps = 38/225 (16%) Query: 25 IGQGTFGEVFKAR---------HRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-K 74 +G+G FG+V A +R T KVA+K +L + E + E+++++++ K Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVT--KVAVK-MLKSDATEKDLSDLISEMEMMKMIGK 92 Query: 75 HENVVNLIEICRTKASPY----NRCKGSI--YLV------FDFC---EHDLAGLLSNVLV 119 H+N++NL+ C Y KG++ YL ++C H+ LS+ + Sbjct: 93 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 152 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 ++ R G+ Y+ K +HRD+ A NVL+T D V+K+ADFGLAR Sbjct: 153 VSCAYQVAR-------GMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 205 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + + TN + + + PE L +R Y D+W G ++ E++T Sbjct: 206 YK--KTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFT 247 >1KOA-A nrPDB Length = 491 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 83/340 (24%), Positives = 136/340 (40%), Gaps = 53/340 (15%) Query: 3 KQY--DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM--ENEKEG 58 KQY VE + Y+ ++G G FG V + R TG A K V+ E++KE Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKE- 93 Query: 59 FPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV 117 T +EI+ + +L+H +VNL + + ++++F +L +++ Sbjct: 94 ---TVRKEIQTMSVLRHPTLVNLHDAFEDD--------NEMVMIYEFMSGGELFEKVADE 142 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFS 175 K + E M+ + GL ++H N +H D+K N++ T R LKL DFGL Sbjct: 143 HNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD 202 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 ++ + T + PE+ G + G D+W G Sbjct: 203 PKQSVKVT-----TGTAEFAAPEVAEG-KPVGYYTDMWSVGV------------------ 238 Query: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 L+ I L ++P N D E L VK + D + + + D I KL Sbjct: 239 --LSYI--LLSGLSPFGGENDD-----ETLRNVKSCDWNMDDSAFSGISED-GKDFIRKL 288 Query: 296 LVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSM 335 L+ DP R+ AL H + P + S+ T + Sbjct: 289 LLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKI 328 >4KIK-B nrPDB Length = 677 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 102/213 (47%), Gaps = 17/213 (7%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E ++G G FG V + +++TG+++A+K+ E L EI+I++ L H NV Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNV 79 Query: 79 VNLIEICRTKASPYNRCKGSI-YLVFDFCEH-DLAGLLSNVLVKFTLSE--IKRVMQMLL 134 V ++ N + L ++C+ DL L+ L E I ++ + Sbjct: 80 VAARDV---PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 136 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + L Y+H N+I+HRD+K N+++ + + K+ D G A+ Q + T+ V T Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKEL-----DQGSLCTSFVGT 191 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 L Y PE LL ++ Y +D W G + E T Sbjct: 192 LQYLAPE-LLEQQKYTVTVDYWSFGTLAFECIT 223 >5TE0-A nrPDB Length = 347 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 101/215 (46%), Gaps = 28/215 (13%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ-LLKHENVVNLIE 83 + +G F VF R G K ALK++ + NE + REI+I++ L H+N+V I+ Sbjct: 27 LAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHD--LQVCKREIQIMRDLSGHKNIVGYID 83 Query: 84 ICRTKASPYNRCKGSIY---LVFDFCEHDLAGLLSNVL-----VKFTLSEIKRVMQMLLN 135 +S N G ++ ++ DFC G + N++ FT +E+ ++ Sbjct: 84 -----SSINNVSSGDVWEVLILMDFCR---GGQVVNLMNQRLQTGFTENEVLQIFCDTCE 135 Query: 136 GLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLA-RAFSLAKNSQPNRYTNRV--- 189 + +H+ K I+HRD+K N+L+ G L DFG A F + N + + Sbjct: 136 AVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKY 195 Query: 190 VTLWYRPPEL--LLGERDYGPPIDLWGAGCIMAEM 222 TL YR PE+ L + D+W GC++ ++ Sbjct: 196 TTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >3UTO-A nrPDB Length = 573 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 83/340 (24%), Positives = 136/340 (40%), Gaps = 53/340 (15%) Query: 3 KQY--DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM--ENEKEG 58 KQY VE + Y+ ++G G FG V + R TG A K V+ E++KE Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKE- 199 Query: 59 FPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV 117 T +EI+ + +L+H +VNL + + ++++F +L +++ Sbjct: 200 ---TVRKEIQTMSVLRHPTLVNLHDAFEDD--------NEMVMIYEFMSGGELFEKVADE 248 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFS 175 K + E M+ + GL ++H N +H D+K N++ T R LKL DFGL Sbjct: 249 HNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLD 308 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 ++ + T + PE+ G + G D+W G Sbjct: 309 PKQSVKVT-----TGTAEFAAPEVAEG-KPVGYYTDMWSVGV------------------ 344 Query: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 L+ I L ++P N D E L VK + D + + + D I KL Sbjct: 345 --LSYI--LLSGLSPFGGENDD-----ETLRNVKSCDWNMDDSAFSGISED-GKDFIRKL 394 Query: 296 LVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSM 335 L+ DP R+ AL H + P + S+ T + Sbjct: 395 LLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKI 434 >2OZO-A nrPDB Length = 613 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 21/204 (10%) Query: 24 KIGQGTFGEVFKA--RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 ++G G FG V + R RK VA+K VL + ++ +RE +I+ L + +V L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV----KFTLSEIKRVMQMLLNGL 137 I +C+ +A + LV + G L LV + +S + ++ + G+ Sbjct: 402 IGVCQAEA---------LMLVMEMAG---GGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ +HR++ A NVL+ K++DFGL++A + R + WY P Sbjct: 450 KYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 Query: 198 ELLLGERDYGPPIDLWGAGCIMAE 221 + R + D+W G M E Sbjct: 510 --CINFRKFSSRSDVWSYGVTMWE 531 >5TQX-A nrPDB Length = 655 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 94/209 (44%), Gaps = 16/209 (7%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E ++G G FG V +HR+ K+A+K +E + EI+I++ L H NV Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRE-RWCHEIQIMKKLNHANV 68 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV--LVKFTLSEIKRVMQMLLN 135 V + C L ++C DL LL+ S+I ++ + + Sbjct: 69 V---KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 136 GLYYIHRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 G+ Y+H NKI+HRD+K N+++ G + K+ D G A+ Q T V TL Sbjct: 126 GIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDV-----DQGELCTEFVGTL 180 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAE 221 Y PE L + Y +D W G ++ E Sbjct: 181 QYLAPE-LFENKPYTATVDYWSFGTMVFE 208 >4IDT-A nrPDB Length = 356 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 96/209 (45%), Gaps = 34/209 (16%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 ++G+G+FGEV + ++TG + A+KKV +E + E+ L +V L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLE-------VFRAEELMACAGLTSPRIVPLYG 133 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV--MQMLLNGLYYIH 141 R P+ + + + E G L V + L E + + + L GL Y+H Sbjct: 134 AVRE--GPW------VNIFMELLEGGSLGQL--VKEQGCLPEDRALYYLGQALEGLEYLH 183 Query: 142 RNKILHRDMKAANVLITRDGV-LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP---- 196 +ILH D+KA NVL++ DG L DFG A QP+ ++T Y P Sbjct: 184 SRRILHGDVKADNVLLSSDGSHAALCDFGHAVCL------QPDGLGKDLLTGDYIPGTET 237 Query: 197 ---PELLLGERDYGPPIDLWGAGCIMAEM 222 PE++LG R +D+W + C+M M Sbjct: 238 HMAPEVVLG-RSCDAKVDVWSSCCMMLHM 265 >1JPA-A nrPDB Length = 312 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 101/209 (48%), Gaps = 27/209 (12%) Query: 25 IGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQLLKHENV 78 IG G FGEV + G++ VA+K + E ++ F L E I+ H NV Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDF----LSEASIMGQFDHPNV 96 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 ++L E TK++P + ++ +F E+ L L +FT+ ++ +++ + G+ Sbjct: 97 IHL-EGVVTKSTP-------VMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 148 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN----RVVTLW 193 Y+ +HRD+ A N+L+ + V K++DFGL+R F S P YT+ ++ W Sbjct: 149 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSR-FLEDDTSDPT-YTSALGGKIPIRW 206 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEM 222 P + R + D+W G +M E+ Sbjct: 207 TAPEAIQY--RKFTSASDVWSYGIVMWEV 233 >4P5Q-A nrPDB Length = 361 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 95/205 (46%), Gaps = 21/205 (10%) Query: 25 IGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQLLKHENV 78 +G G FGEV R + +K VA+K + E ++ F L E I+ H N+ Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDF----LGEASIMGQFDHPNI 96 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + L E TK+ P + +V ++ E+ L L +FT+ ++ +++ + +G+ Sbjct: 97 IRL-EGVVTKSKP-------VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGM 148 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ +HRD+ A N+LI + V K++DFGL+R + ++ W P Sbjct: 149 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPE 208 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEM 222 + R + D+W G ++ E+ Sbjct: 209 A--IAYRKFTSASDVWSYGIVLWEV 231 >1ZWS-A nrPDB Length = 288 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 129/313 (41%), Gaps = 58/313 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVA---LKKVLMENEKEGFPITAL-REIKILQLLK 74 Y+ ++G G F V K R + TG + A +KK + G + RE+ IL+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSE--IKRVMQ 131 H NV+ L ++ + + L+ + G L + L K +LSE ++ Sbjct: 74 HHNVITLHDVYENRTD--------VVLILELVS---GGELFDFLAQKESLSEEEATSFIK 122 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTN 187 +L+G+ Y+H KI H D+K N+++ + +KL DFGLA + N Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI-----EDGVEFKN 177 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T + PE++ E G D+W G I + + + G+T+Q LA I+ + Sbjct: 178 IFGTPEFVAPEIVNYE-PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYD 236 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 E + + EL K D I KLLV + +R+ Sbjct: 237 FDEEFFSHTS--------ELAK--------------------DFIRKLLVKETRKRLTIQ 268 Query: 308 DALNHDFFWSDPM 320 +AL H W P+ Sbjct: 269 EALRHP--WITPV 279 >1S9I-A nrPDB Length = 354 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 83/317 (26%), Positives = 137/317 (43%), Gaps = 39/317 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E+++++G G G V K +HR +G +A K + +E K +RE+++L + Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYI 76 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEI-KRVMQMLLN 135 V + Y+ + SI + EH G L VL K EI +V +L Sbjct: 77 VGFY------GAFYSDGEISICM-----EHMDGGSLDQVLKEAKRIPEEILGKVSIAVLR 125 Query: 136 GLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 GL Y+ +++I+HRD+K +N+L+ G +KL DFG++ +S N + V T Y Sbjct: 126 GLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI---DSMANSF---VGTRSY 179 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNT--------------EQHQLA 239 PE L G Y D+W G + E+ R PI + E+ + Sbjct: 180 MAPERLQGTH-YSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPH 238 Query: 240 LISQLCGSITPEVWPN-VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 IS V + +D+ EL+ + +L V P + ++K L+ Sbjct: 239 SISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIK 298 Query: 299 DPAQRIDSDDALNHDFF 315 +PA+R D NH F Sbjct: 299 NPAERADLKMLTNHTFI 315 >5AP3-A nrPDB Length = 313 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 89/316 (28%), Positives = 135/316 (42%), Gaps = 70/316 (22%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH--E 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLL 134 ++ L + Y IY+V + DL G L K ++ E K + +L Sbjct: 89 KIIRLYD--------YEITDQYIYMVMECGNIDLNGWLKK---KKSIDPWERKSYWKNML 137 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF-----SLAKNSQPNRYTNRV 189 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S+ K+SQ V Sbjct: 138 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-------V 189 Query: 190 VTLWYRPPEL---LLGERDYG-------PPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQL 238 T+ Y PPE + R+ G P D+W GCI+ M + ++P Q + Sbjct: 190 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQII 243 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 IS+L I P N+E +E ++ ++D LK L Sbjct: 244 NQISKLHAIIDP-------NHE----IEFPDIPEKDLQDVLKC-------------CLKR 279 Query: 299 DPAQRIDSDDALNHDF 314 DP QRI + L H + Sbjct: 280 DPKQRISIPELLAHPY 295 >5N23-A nrPDB Length = 352 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 106/215 (49%), Gaps = 20/215 (9%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIK-ILQLLK 74 + ++E++ +G G+FG V +H++TG A+K +++ +K + L++I+ L + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMK--ILDKQK----VVKLKQIEHTLNEKR 94 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNV--LVKFTLSEIKRVMQM 132 + VN + + + S + ++Y+V ++ + S++ + +F+ + Sbjct: 95 IQQAVNFPFLVKLEFS--FKDNSNLYMVLEYAPG--GEMFSHLRRIGRFSEPHARFYAAQ 150 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 ++ Y+H +++RD+K N+LI + G +K+ADFG A+ K P T Sbjct: 151 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKR---VKGRTPWTLCG---TP 204 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 Y PE++L + Y +D W G ++ EM P Sbjct: 205 EYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYP 238 >2A27-A nrPDB Length = 321 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 128/313 (40%), Gaps = 58/313 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVA---LKKVLMENEKEGFPITAL-REIKILQLLK 74 Y+ ++G G F V K R + TG + A +KK + G + RE+ IL+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSE--IKRVMQ 131 H NV+ L ++ + + L+ + G L + L K +LSE ++ Sbjct: 74 HHNVITLHDVYENRTD--------VVLILELVS---GGELFDFLAQKESLSEEEATSFIK 122 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTN 187 +L+G+ Y+H KI H D+K N+++ + +KL DFGLA + N Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI-----EDGVEFKN 177 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T + PE++ E G D+W G I + + + G+T+Q LA I+ + Sbjct: 178 IFGTPEFVAPEIVNYE-PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYD 236 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 E + EL K D I KLLV + +R+ Sbjct: 237 FDEEFFSQTS--------ELAK--------------------DFIRKLLVKETRKRLTIQ 268 Query: 308 DALNHDFFWSDPM 320 +AL H W P+ Sbjct: 269 EALRHP--WITPV 279 >2DQ7-X nrPDB Length = 283 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 93/209 (44%), Gaps = 23/209 (11%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVV 79 + ++G G FGEV+ KVA+K + K G P + L E +I++ LKH+ +V Sbjct: 14 IKRLGNGQFGEVWMGTWNGN-TKVAIKTL-----KPGTMSPESFLEEAQIMKKLKHDKLV 67 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 L + + IY+V ++ L L L + + + G+ Sbjct: 68 QLYAVVSEE---------PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGM 118 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 YI R +HRD+++AN+L+ + K+ADFGLAR + N R + W P Sbjct: 119 AYIERMNYIHRDLRSANILVGNGLICKIADFGLARL--IEDNEYTARQGAKFPIKWTAPE 176 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 L G + D+W G ++ E+ T+ Sbjct: 177 AALYGR--FTIKSDVWSFGILLTELVTKG 203 >3KN6-A nrPDB Length = 325 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 74/287 (25%), Positives = 122/287 (42%), Gaps = 49/287 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVNLIE 83 +G+G+F K H+K+ Q A+K + E +EI L+L + H N+V L E Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRME-----ANTQKEITALKLCEGHPNIVKLHE 73 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYYI 140 + + +LV + G L + K F+ +E +M+ L++ + ++ Sbjct: 74 VFHDQLH--------TFLVMELLN---GGELFERIKKKKHFSETEASYIMRKLVSAVSHM 122 Query: 141 HRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H ++HRD+K N+L T + +K+ DFG AR ++QP + TL Y P Sbjct: 123 HDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL--KPPDNQPLK--TPCFTLHYAAP 178 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E LL + Y DLW G I+ M + Q + S C S E+ + Sbjct: 179 E-LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDR-------SLTCTSAV-EIMKKIK 229 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 + + E K ++ K DLI LL +DP +R+ Sbjct: 230 KGDFSFEGEAWKNVSQEAK-------------DLIQGLLTVDPNKRL 263 >2X4F-A nrPDB Length = 373 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 78/307 (25%), Positives = 132/307 (42%), Gaps = 64/307 (20%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 VSK E L G G FG+V K TG K+A K + K+ + EI ++ L H Sbjct: 91 VSKTEIL---GGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVK--NEISVMNQLDH 145 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV--KFTLSEIKRV--MQ 131 N++ L + +K I LV ++ + G L + ++ + L+E+ + M+ Sbjct: 146 ANLIQLYDAFESK--------NDIVLVMEYVD---GGELFDRIIDESYNLTELDTILFMK 194 Query: 132 MLLNGLYYIHRNKILHRDMKAANVL-ITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRV 189 + G+ ++H+ ILH D+K N+L + RD +K+ DFGLAR + + + N Sbjct: 195 QICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVN------ 248 Query: 190 VTLWYRPPELLLGE---RDY-GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 + PE L E D+ P D+W G I + L+ +S Sbjct: 249 ----FGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYML---------------LSGLSPFL 289 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 G E N+ L + +L + + + + K + I KLL+ + + RI Sbjct: 290 GDNDAETLNNI----LACRWDLEDEEFQDISEEAKEF---------ISKLLIKEKSWRIS 336 Query: 306 SDDALNH 312 + +AL H Sbjct: 337 ASEALKH 343 >2Y6O-A nrPDB Length = 291 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 100/212 (47%), Gaps = 23/212 (10%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKV---LMENEKEGFPITALREIKILQ 71 K EK+ IG G FGEV R + G++ VA+K + + ++ F L E I+ Sbjct: 17 KIEKV--IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDF----LSEASIMG 70 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 H N+++L E TK P + ++ ++ E+ L L +FT+ ++ ++ Sbjct: 71 QFDHPNIIHL-EGVVTKCKP-------VMIITEYMENGSLDAFLRKNDGRFTVIQLVGML 122 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + +G+ Y+ +HRD+ A N+L+ + V K++DFG++R + ++ Sbjct: 123 RGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIP 182 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 W P + R + D+W G +M E+ Sbjct: 183 IRWTAPEAIAY--RKFTSASDVWSYGIVMWEV 212 >2XYN-A nrPDB Length = 292 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 99/207 (47%), Gaps = 25/207 (12%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLI 82 K+G G +GEV+ +K VA+K + + E E F L+E +++ +KH N+V L+ Sbjct: 39 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEF----LKEAAVMKEIKHPNLVQLL 94 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL-----NGL 137 +C T P+ Y+V ++ + G L + L + E+ V+ + + + + Sbjct: 95 GVC-TLEPPF-------YIVTEYMPY---GNLLDYLRECNREEVTAVVLLYMATQISSAM 143 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ + +HRD+ A N L+ + V+K+ADFGL+R + ++ + W P Sbjct: 144 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL--MTGDTYTAHAGAKFPIKWTAPE 201 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWT 224 L + D+W G ++ E+ T Sbjct: 202 S--LAYNTFSIKSDVWAFGVLLWEIAT 226 >3TT0-A nrPDB Length = 382 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 108/226 (47%), Gaps = 40/226 (17%) Query: 25 IGQGTFGEVFKAR---------HRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-K 74 +G+G FG+V A +R T KVA+K +L + E + E+++++++ K Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVT--KVAVK-MLKSDATEKDLSDLISEMEMMKMIGK 133 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLS---------------NVL 118 H+N++NL+ C G +Y++ ++ + +L L N Sbjct: 134 HKNIINLLGACTQD--------GPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPE 185 Query: 119 VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + ++ + G+ Y+ K +HRD+ A NVL+T D V+K+ADFGLAR Sbjct: 186 EQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID 245 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + + TN + + + PE L +R Y D+W G ++ E++T Sbjct: 246 YYK--KTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFT 288 >6GVJ-A nrPDB Length = 429 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 88/316 (27%), Positives = 134/316 (42%), Gaps = 70/316 (22%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH--E 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLL 134 ++ L + Y IY+V + DL L K ++ E K + +L Sbjct: 205 KIIRLYD--------YEITDQYIYMVMECGNIDLNSWLKK---KKSIDPWERKSYWKNML 253 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF-----SLAKNSQPNRYTNRV 189 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S+ K+SQ V Sbjct: 254 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-------V 305 Query: 190 VTLWYRPPEL---LLGERDYG-------PPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQL 238 T+ Y PPE + R+ G P D+W GCI+ M + ++P Q + Sbjct: 306 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQII 359 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 IS+L I P N+E +E ++ ++D LK L Sbjct: 360 NQISKLHAIIDP-------NHE----IEFPDIPEKDLQDVLKC-------------CLKR 395 Query: 299 DPAQRIDSDDALNHDF 314 DP QRI + L H + Sbjct: 396 DPKQRISIPELLAHPY 411 >3PPZ-A nrPDB Length = 309 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/176 (32%), Positives = 88/176 (50%), Gaps = 19/176 (10%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 A D ++ P+CD K KIG G+FG V +A G VA+K +LME + + Sbjct: 26 AMDGDDMDIPWCDLNIK----EKIGAGSFGTVHRAEWH--GSDVAVK-ILMEQDFHAERV 78 Query: 62 TA-LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 LRE+ I++ L+H N+V + P N + YL L LL + Sbjct: 79 NEFLREVAIMKRLRHPNIVLFMGAV---TQPPNLSIVTEYL----SRGSLYRLLHKSGAR 131 Query: 121 FTLSEIKRVMQM--LLNGLYYIH-RNK-ILHRDMKAANVLITRDGVLKLADFGLAR 172 L E +R+ + G+ Y+H RN I+HRD+K+ N+L+ + +K+ DFGL+R Sbjct: 132 EQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSR 187 >5B2L-A nrPDB Length = 324 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 101/222 (45%), Gaps = 32/222 (14%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 E++ E L ++G GT G+V+K R RKTG +A+K++ KE +IL Sbjct: 15 EINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKE-------ENKRIL---- 63 Query: 75 HENVVNLIEICRTKASPY-NRCKGSIYLVFD-FCEHDLAGLLSNVLVKFTLSEI-----K 127 ++L + ++ PY +C G+ D F +L G + L K I Sbjct: 64 ----MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILG 119 Query: 128 RVMQMLLNGLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ ++ LYY+ ++ ++HRD+K +N+L+ G +KL DFG++ +K T Sbjct: 120 KMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK-----T 174 Query: 187 NRVVTLWYRPPELL----LGERDYGPPIDLWGAGCIMAEMWT 224 Y PE + + DY D+W G + E+ T Sbjct: 175 RSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 216 >5H2U-A nrPDB Length = 267 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 103/219 (47%), Gaps = 18/219 (8%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 K+G G FGEVF+ + Q VA+K + +N + + EI+ ++ L+H++++ L Sbjct: 13 KLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNLLHQQMLQS--EIQAMKKLRHKHILALYA 69 Query: 84 ICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVK-FTLSEIKRVMQMLLNGLYYIH 141 + + P +Y++ + + L LL + K +SE+ + + G+ Y+ Sbjct: 70 VV-SVGDP-------VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 +HRD+ A N+L+ + + K+ DFGLAR L K + + + W P L Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLAR---LIKEDVYLSHDHNIPYKWTAPEALSR 178 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 G Y D+W G ++ EM++R + H+ L Sbjct: 179 GH--YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFL 215 >5HI2-A nrPDB Length = 283 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 107/232 (46%), Gaps = 23/232 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 +IG G+FG V+K K VA+K +L + + F E+ +L+ +H N++ + Sbjct: 27 RIGSGSFGTVYKG---KWHGDVAVK-MLTPQQLQAFK----NEVGVLRKTRHVNILLFMG 78 Query: 84 ICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142 K + +V +CE L L KF + ++ + + G+ Y+H Sbjct: 79 YS---------TKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHA 129 Query: 143 NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG 202 I+HRD+K+ N+ + D +K+ DFGLA S S + + LW P + + Sbjct: 130 KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSI-LWMAPEVIRMQ 188 Query: 203 ERD-YGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEV 252 + + Y D++ G ++ E+ T + P N + ++ + GS++P++ Sbjct: 189 DSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGR--GSLSPDL 238 >3HKO-A nrPDB Length = 345 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 81/341 (23%), Positives = 132/341 (38%), Gaps = 82/341 (24%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR---EIKILQLLK 74 KY IGQG++G V A +T A+K + ++ P R E+++++ L Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE------------HDLAGLLSNVLVK-- 120 H N+ L E+ + I LV + C D G + +VK Sbjct: 87 HPNIARLYEVYEDEQY--------ICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQ 138 Query: 121 ------------------------FTLSE--IKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 F E I +M+ + + L+Y+H I HRD+K N Sbjct: 139 ICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPEN 198 Query: 155 VLITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL-LGERDYGPPID 211 L + + +KL DFGL++ F N + T + T ++ PE+L YGP D Sbjct: 199 FLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCD 258 Query: 212 LWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQ 271 W AG ++ H L L G++ +P V++ + ++ Sbjct: 259 AWSAGVLL----------------HLL-----LMGAVP---FPGVNDADTISQVL----N 290 Query: 272 KRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 K+ + V P A DL+ LL + +R D+ AL H Sbjct: 291 KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQH 331 >5X5O-A nrPDB Length = 310 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 99/213 (46%), Gaps = 34/213 (15%) Query: 26 GQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEIC 85 G G+FG V++A+ ++VA+KK L++ EKE +IL +L H N++ + Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKK-LLKIEKEA---------EILSVLSHRNIIQFYGVI 73 Query: 86 RTKASPYNRC----KGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIH 141 P N S+ ++D+ + SN + + I + G++Y+H Sbjct: 74 ---LEPPNYGIVTEYASLGSLYDY-------INSNRSEEMDMDHIMTWATDVAKGMHYLH 123 Query: 142 RN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 K++HRD+K+ NV+I DGVLK+ DFG +R + + + V T + PE Sbjct: 124 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN------HTTHMSLVGTFPWMAPE 177 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 ++ D + G ++ EM TR +G Sbjct: 178 -VIQSLPVSETCDTYSYGVVLWEMLTREVPFKG 209 >1AD5-A nrPDB Length = 438 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 102/222 (45%), Gaps = 35/222 (15%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITAL 64 D+ E P E K EK K+G G FGEV+ A + K KVA+K + + E F L Sbjct: 175 DAWEIP--RESLKLEK--KLGAGQFGEVWMATYNKH-TKVAVKTMKPGSMSVEAF----L 225 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLVKFT 122 E +++ L+H+ +V L + K IY++ +F L L S+ K Sbjct: 226 AEANVMKTLQHDKLVKLHAVV---------TKEPIYIITEFMAKGSLLDFLKSDEGSKQP 276 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 L ++ + G+ +I + +HRD++AAN+L++ V K+ADFGLAR + Sbjct: 277 LPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVGA------- 329 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + W P + G + D+W G ++ E+ T Sbjct: 330 -----KFPIKWTAPEAINFG--SFTIKSDVWSFGILLMEIVT 364 >4OW8-A nrPDB Length = 283 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 92/201 (45%), Gaps = 14/201 (6%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLIE 83 I G G+V++A + G++VA+K + E + I R E + +L H + ++ + Sbjct: 19 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 78 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLYYI 140 ++ + R YLV + + L++VL + ++ + ML L Sbjct: 79 YGESQMNGEGRTA---YLVMELVNGEP---LNSVLKRTGRLSLRHALDMLEQTGRALQIA 132 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 H ++HRD+K N+LIT G +K+ DFG+A+A A +Q T Y PE Sbjct: 133 HAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG---TAQYIAPEQA 189 Query: 201 LGERDYGPPIDLWGAGCIMAE 221 LG D P D++ G + E Sbjct: 190 LGH-DASPASDVYSLGVVGYE 209 >4AT3-A nrPDB Length = 299 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 102/221 (46%), Gaps = 35/221 (15%) Query: 24 KIGQGTFGEVFKAR-------HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 ++G+G FG+VF A K V K +N ++ F RE ++L L+HE Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFH----REAELLTNLQHE 75 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL------------SNVLVKFTL 123 ++V +C + P + +VF++ +H DL L N + T Sbjct: 76 HIVKFYGVC-VEGDP-------LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 S++ + Q + G+ Y+ +HRD+ N L+ + ++K+ DFG++R + Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVG 187 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 +T ++ + + PPE ++ R + D+W G ++ E++T Sbjct: 188 GHT--MLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFT 225 >4X3F-A nrPDB Length = 337 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 92/201 (45%), Gaps = 14/201 (6%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLIE 83 I G G+V++A + G++VA+K + E + I R E + +L H + ++ + Sbjct: 20 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 79 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML---LNGLYYI 140 ++ + R YLV + + L++VL + ++ + ML L Sbjct: 80 YGESQMNGEGRTA---YLVMELVNGEP---LNSVLKRTGRLSLRHALDMLEQTGRALQIA 133 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 H ++HRD+K N+LIT G +K+ DFG+A+A A +Q T Y PE Sbjct: 134 HAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG---TAQYIAPEQA 190 Query: 201 LGERDYGPPIDLWGAGCIMAE 221 LG D P D++ G + E Sbjct: 191 LGH-DASPASDVYSLGVVGYE 210 >6J5U-C nrPDB Length = 426 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 110/235 (46%), Gaps = 36/235 (15%) Query: 25 IGQGTFGEVFK---------ARHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLL 73 +G+G FG VFK A +G VA+K++ + EGF L E+ L L Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQL----KPEGFQGHKEWLTEVNYLGQL 147 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H N+V L+ C A NR LV++F G L N L + + ++M Sbjct: 148 SHPNLVLLVGYC---AEGENRL-----LVYEFMP---KGSLENHLFRRGAQPLTWAIRMK 196 Query: 134 L-----NGLYYIH--RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + GL ++H ++++++RD KAAN+L+ D KL+DFGLA+A N+ + T Sbjct: 197 VAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVS--T 254 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 + T Y PE + R D++ G ++ E+ + M + ++ +L+ Sbjct: 255 KVIGTHGYAAPEYVATGR-LTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 >4WB7-A nrPDB Length = 405 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 50/225 (22%), Positives = 102/225 (45%), Gaps = 41/225 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + ++E++ +G G+FG V +H++TG A+K L + K+++L + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMK--------------ILDKQKVVKLKQI 140 Query: 76 ENVVNLIEICRTKASPY-------NRCKGSIYLVFDFCEHDLAGLLSNV--LVKFTLSEI 126 E+ +N I + P+ + ++Y+V ++ + S++ + +F+ Sbjct: 141 EHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPG--GEMFSHLRRIGRFSEPHA 198 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + ++ Y+H +++RD+K N+LI + G +++ DFG A+ R Sbjct: 199 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----------RVK 247 Query: 187 NRVVTLW----YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 R TL Y PE++L + Y +D W G ++ EM P Sbjct: 248 GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYP 291 >2YAB-A nrPDB Length = 361 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 77/315 (24%), Positives = 129/315 (40%), Gaps = 58/315 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVA---LKKVLMENEKEGFPITAL-REIKILQLLK 74 Y+ ++G G F V K R + TG + A +KK + G + RE+ IL+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSE--IKRVMQ 131 H N++ L ++ + + L+ + G L + L K +LSE ++ Sbjct: 74 HPNIITLHDVYENRTD--------VVLILELVS---GGELFDFLAQKESLSEEEATSFIK 122 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTN 187 +L+G+ Y+H KI H D+K N+++ + +KL DFGLA + N Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI-----EDGVEFKN 177 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T + PE++ E G D+W G I + + + G+T+Q LA I+ + Sbjct: 178 IFGTPEFVAPEIVNYE-PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYD 236 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 E + EL K D I KLLV + +R+ Sbjct: 237 FDEEFFSQTS--------ELAK--------------------DFIRKLLVKETRKRLTIQ 268 Query: 308 DALNHDFFWSDPMPS 322 +AL H W P+ + Sbjct: 269 EALRHP--WITPVDT 281 >2HW6-A nrPDB Length = 307 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 79/314 (25%), Positives = 133/314 (42%), Gaps = 43/314 (13%) Query: 17 SKYEKLAKI-----GQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL- 70 K+E + K+ G+G + +V A + G++ A+K ++E + RE++ L Sbjct: 8 GKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVK--IIEKQAGHSRSRVFREVETLY 65 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKR 128 Q ++N++ LIE YLVF+ + +L+++ + F E R Sbjct: 66 QCQGNKNILELIEFFEDDTR--------FYLVFEKLQG--GSILAHIQKQKHFNEREASR 115 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQP--- 182 V++ + L ++H I HRD+K N+L + +K+ DF L L + P Sbjct: 116 VVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITT 175 Query: 183 NRYTNRVVTLWYRPPELLLGERD----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 T + Y PE++ D Y DLW G ++ M + P G+ Sbjct: 176 PELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD-- 233 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 CG EV N +L+E ++ K + D+ A++ A DLI KLLV Sbjct: 234 ------CGWDRGEVCRVCQN-KLFES---IQEGKYEFPDKDWAHISSE-AKDLISKLLVR 282 Query: 299 DPAQRIDSDDALNH 312 D QR+ + L H Sbjct: 283 DAKQRLSAAQVLQH 296 >3HMP-A nrPDB Length = 342 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 88/316 (27%), Positives = 134/316 (42%), Gaps = 70/316 (22%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH--E 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLL 134 ++ L + Y IY+V + DL L K ++ E K + +L Sbjct: 117 KIIRLYD--------YEITDQYIYMVMECGNIDLNSWLKK---KKSIDPWERKSYWKNML 165 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF-----SLAKNSQPNRYTNRV 189 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S+ K+SQ V Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-------V 217 Query: 190 VTLWYRPPEL---LLGERDYG-------PPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQL 238 T+ Y PPE + R+ G P D+W GCI+ M + ++P Q + Sbjct: 218 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQII 271 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 IS+L I P N+E +E ++ ++D LK L Sbjct: 272 NQISKLHAIIDP-------NHE----IEFPDIPEKDLQDVLKC-------------CLKR 307 Query: 299 DPAQRIDSDDALNHDF 314 DP QRI + L H + Sbjct: 308 DPKQRISIPELLAHPY 323 >1VZO-A nrPDB Length = 355 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 77/328 (23%), Positives = 142/328 (43%), Gaps = 73/328 (22%) Query: 16 VSKYEKLAKIGQGTFGEVFKARH---RKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 + +E L +G G +G+VF R TG+ A+K VL + T +++ K + Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMK-VLKKA-------TIVQKAKTTEH 104 Query: 73 LKHENVVNLIEICRTKASPY-------NRCKGSIYLVFDFCEHDLAGLLSNVLV---KFT 122 + E V + + SP+ + + ++L+ D+ G L L +FT Sbjct: 105 TRTERQV----LEHIRQSPFLVTLHYAFQTETKLHLILDYIN---GGELFTHLSQRERFT 157 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 E++ + ++ L ++H+ I++RD+K N+L+ +G + L DFGL++ F + Sbjct: 158 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFV---ADET 214 Query: 183 NRYTNRVVTLWYRPPELLL-GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 R + T+ Y P+++ G+ + +D W G +M E+ T + + E++ A I Sbjct: 215 ERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEI 274 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL--DLIDKLLVLD 299 S R++ Y ++ AL DLI +LL+ D Sbjct: 275 S------------------------------RRILKSEPPYPQEMSALAKDLIQRLLMKD 304 Query: 300 PAQRI-----DSDDALNHDFF----WSD 318 P +R+ D+D+ H FF W D Sbjct: 305 PKKRLGCGPRDADEIKEHLFFQKINWDD 332 >6B2Q-A nrPDB Length = 317 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 92/201 (45%), Gaps = 14/201 (6%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLIE 83 I G G+V++A + G++VA+K + E + I R E + +L H + ++ + Sbjct: 40 IATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASVHD 99 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLYYI 140 ++ + R YLV + + L++VL + ++ + ML L Sbjct: 100 YGESQMNGEGRTA---YLVMELVNGEP---LNSVLKRTGRLSLRHALDMLEQTGRALQIA 153 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 H ++HRD+K N+LIT G +K+ DFG+A+A A +Q T Y PE Sbjct: 154 HAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG---TAQYIAPEQA 210 Query: 201 LGERDYGPPIDLWGAGCIMAE 221 LG D P D++ G + E Sbjct: 211 LGH-DASPASDVYSLGVVGYE 230 >3BEA-A nrPDB Length = 333 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 38/223 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLME--------NEKEGFPITALREIKIL-QLLKH 75 +G G FG+V +A G++ A+ KV ++ +EKE + E+KI+ L +H Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 109 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL---SNVL--------VKFTL 123 EN+VNL+ C T P + ++ ++C + DL L S VL TL Sbjct: 110 ENIVNLLGAC-THGGP-------VLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTL 161 Query: 124 S--EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 S ++ + G+ ++ +HRD+ A NVL+T V K+ DFGLAR + ++ Sbjct: 162 STRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MNDSNY 220 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + R+ W P + + Y D+W G ++ E+++ Sbjct: 221 IVKGNARLPVKWMAPESIF--DCVYTVQSDVWSYGILLWEIFS 261 >2QLU-A nrPDB Length = 314 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 66/230 (28%), Positives = 108/230 (46%), Gaps = 31/230 (13%) Query: 26 GQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEIC 85 +G FG V+KA+ VA+K +++++ + REI +KHEN++ I Sbjct: 24 ARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQS---WQSEREIFSTPGMKHENLLQFIAAE 78 Query: 86 RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGLYYIHRN 143 + ++ + ++L+ F HD G L++ L T +E+ V + + GL Y+H + Sbjct: 79 KRGSN----LEVELWLITAF--HD-KGSLTDYLKGNIITWNELCHVAETMSRGLSYLHED 131 Query: 144 -----------KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 I HRD K+ NVL+ D LADFGLA F K P +V T Sbjct: 132 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGK--PPGDTHGQVGTR 189 Query: 193 WYRPPELLLG----ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 Y PE+L G +RD ID++ G ++ E+ +R G +++ L Sbjct: 190 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYML 239 >1NY3-A nrPDB Length = 400 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 122/300 (40%), Gaps = 53/300 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G G+V + +++T +K ALK +L + K A RE+++ H I Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALK-MLQDCPK------ARREVEL-----HWRASQCPHI 117 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLNGLYYI 140 R N G L+ D L S + + FT E +M+ + + Y+ Sbjct: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 Query: 141 HRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H I HRD+K N+L T + +LKL DFG A+ + + N T T +Y P Sbjct: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYYVAP 232 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW--PN 255 E +LG Y D+W G IM + P N H LA+ + I + PN Sbjct: 233 E-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN 288 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + E+ E++++ LI LL +P QR+ + +NH + Sbjct: 289 PEWSEVSEEVKM-----------------------LIRNLLKTEPTQRMTITEFMNHPWI 325 >2OZA-A nrPDB Length = 356 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 77/300 (25%), Positives = 122/300 (40%), Gaps = 53/300 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G G+V + +++T +K ALK +L + K A RE+++ H I Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALK-MLQDCPK------ARREVEL-----HWRASQCPHI 73 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLNGLYYI 140 R N G L+ D L S + + FT E +M+ + + Y+ Sbjct: 74 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 133 Query: 141 HRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H I HRD+K N+L T + +LKL DFG A+ + + N T T +Y P Sbjct: 134 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYYVAP 188 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW--PN 255 E +LG Y D+W G IM + P N H LA+ + I + PN Sbjct: 189 E-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN 244 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + E+ E++++ LI LL +P QR+ + +NH + Sbjct: 245 PEWSEVSEEVKM-----------------------LIRNLLKTEPTQRMTITEFMNHPWI 281 >4PL5-B nrPDB Length = 435 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 74/302 (24%), Positives = 128/302 (42%), Gaps = 53/302 (17%) Query: 25 IGQGTFGE-VFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHENVVNLI 82 +G G G V+K + VA+K++L E F A RE+++L + +H NV+ Sbjct: 35 LGHGAEGTIVYKGMF--DNRDVAVKRIL----PECFSF-ADREVQLLRESDEHPNVIRYF 87 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142 C K + Y+ + C L + E ++ +GL ++H Sbjct: 88 --CTEKDRQFQ------YIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHS 139 Query: 143 NKILHRDMKAANVLIT---RDGVLK--LADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 I+HRD+K N+L++ G +K ++DFGL + ++ ++S R W P Sbjct: 140 LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWI-AP 198 Query: 198 ELLLGERDYGP--PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 E+L + P +D++ AGC+ + + G + Q Q ++ C N Sbjct: 199 EMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGAC---------N 249 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 +D + +K E D A +LI+K++ +DP QR + L H FF Sbjct: 250 LDCFH-SDKHE------------------DVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 Query: 316 WS 317 WS Sbjct: 291 WS 292 >4RA4-A nrPDB Length = 355 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 103/228 (45%), Gaps = 27/228 (11%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKI 69 +++ + L +G+G+FG+V A + T + A+K V+ +++ E + E ++ Sbjct: 18 KLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVE----CTMVEKRV 73 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKR 128 L LL + + C +Y V ++ DL + V KF + Sbjct: 74 LALLDKPPFLTQLHSCFQTVD-------RLYFVMEYVNGGDLMYHIQQV-GKFKEPQAVF 125 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + GL+++H+ I++RD+K NV++ +G +K+ADFG+ + + + T R Sbjct: 126 YAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM------DGVTTR 179 Query: 189 VV--TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 T Y PE ++ + YG +D W G ++ EM P G E Sbjct: 180 TFCGTPDYIAPE-IIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE 226 >3KA0-A nrPDB Length = 320 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G G+V + +++T +K ALK +L + K A RE+++ H I Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALK-MLQDCPK------ARREVEL-----HWRASQCPHI 71 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLNGLYYI 140 R N G L+ D L S + + FT E +M+ + + Y+ Sbjct: 72 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 131 Query: 141 HRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H I HRD+K N+L T + +LKL DFG A+ + + N T T +Y P Sbjct: 132 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTEPCYTPYYVAP 186 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E +LG Y D+W G IM + P N H LA + P + Sbjct: 187 E-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLA------------ISPGMK 230 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + E + +V + +K +R+ LL +P QR+ + +NH + Sbjct: 231 TRIRMGQYEFPNPEWSEVSEEVKMLIRN---------LLKTEPTQRMTITEFMNHPWI 279 >2OGV-A nrPDB Length = 317 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 101/222 (45%), Gaps = 40/222 (18%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLME--------NEKEGFPITALREIKIL-QLLKH 75 +G G FG+V +A G++ A+ KV ++ +EKE + E+KI+ L +H Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 101 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-------------FT 122 EN+VNL+ C G + ++ ++C + G L N L + Sbjct: 102 ENIVNLLGACTHG--------GPVLVITEYCCY---GDLLNFLRRKAEADLDKEDGRPLE 150 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 L ++ + G+ ++ +HRD+ A NVL+T V K+ DFGLAR + ++ Sbjct: 151 LRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MNDSNYI 209 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + R+ W P + + Y D+W G ++ E+++ Sbjct: 210 VKGNARLPVKWMAPESIF--DCVYTVQSDVWSYGILLWEIFS 249 >5UUU-A nrPDB Length = 547 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 115/241 (47%), Gaps = 29/241 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLLKHENVV 79 IG+G FGEV+ R TG+ A+K ++ M K+G AL E +L L+ + Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM---KQG-ETLALNERIMLSLVSTGDCP 261 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 ++ + +P + + D DL LS V F+ ++++ ++ GL Sbjct: 262 FIVCMSYAFHTP-----DKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLE 315 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 ++H +++RD+K AN+L+ G ++++D GLA FS K P+ V T Y PE Sbjct: 316 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PH---ASVGTHGYMAPE 369 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMW-TRSPIMQGNT-EQHQ-----LALISQLCGSITPE 251 +L Y D + GC++ ++ SP Q T ++H+ L + +L S +PE Sbjct: 370 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 429 Query: 252 V 252 + Sbjct: 430 L 430 >5X3F-B nrPDB Length = 393 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/228 (21%), Positives = 106/228 (46%), Gaps = 45/228 (19%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 ++ +++++ +G G+FG V +H+++G A+K L + K+++L + Sbjct: 82 QLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMK--------------ILDKQKVVKLKQ 127 Query: 75 HENVVNLIEICRTKASPY-------NRCKGSIYLVFDFCEHDLAG--LLSNV--LVKFTL 123 E+ +N I + P+ + ++Y+V ++ +AG + S++ + +F+ Sbjct: 128 IEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEY----VAGGEMFSHLRRIGRFSE 183 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 + ++ Y+H +++RD+K N+LI + G +++ DFG A+ Sbjct: 184 PHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK----------- 232 Query: 184 RYTNRVVTLW----YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 R R TL Y PE++L + Y +D W G ++ EM P Sbjct: 233 RVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYP 279 >3KUL-B nrPDB Length = 325 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 94/216 (43%), Gaps = 23/216 (10%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK------VALKKVLMENEKEGFPITALREIK 68 E S+ IG G GEV R R GQ+ ALK E ++ F L E Sbjct: 47 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDF----LSEAS 102 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSI-YLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 I+ H N++ L + +G + +V ++ E+ L L +FT+ ++ Sbjct: 103 IMGQFDHPNIIRLEGVV---------TRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQL 153 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 +++ + G+ Y+ +HRD+ A NVL+ + V K++DFGL+R ++ Sbjct: 154 VGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG 213 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 ++ W P + R + D+W G +M E+ Sbjct: 214 GKIPIRWTAPEAIAF--RTFSSASDVWSFGVVMWEV 247 >5O0Y-A nrPDB Length = 579 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 103/226 (45%), Gaps = 30/226 (13%) Query: 30 FGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 F EV+KA + VA+K K + +KE + A RE +I + L H +V L + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 85 CRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 ++ S V ++CE +DL L + + E + ++ ++N L Y++ Sbjct: 357 -------FSLDTDSFCTVLEYCEGNDLDFYLKQHKL-MSEKEARSIIMQIVNALKYLNEI 408 Query: 144 K--ILHRDMKAANVLI---TRDGVLKLADFGLARAF---SLAKNSQPNRYTNRVVTLWYR 195 K I+H D+K N+L+ T G +K+ DFGL++ S + T WY Sbjct: 409 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYL 468 Query: 196 PPELLLGERDYGPP-----IDLWGAGCIMAE-MWTRSPIMQGNTEQ 235 PPE + ++ PP +D+W G I + ++ R P ++Q Sbjct: 469 PPECFVVGKE--PPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQ 512 >3PVW-A nrPDB Length = 695 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 115/241 (47%), Gaps = 29/241 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLLKHENVV 79 IG+G FGEV+ R TG+ A+K ++ M K+G AL E +L L+ + Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM---KQG-ETLALNERIMLSLVSTGDCP 252 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 ++ + +P + + D DL LS V F+ ++++ ++ GL Sbjct: 253 FIVCMSYAFHTP-----DKLSFILDLMNGGDLHYHLSQHGV-FSEADMRFYAAEIILGLE 306 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 ++H +++RD+K AN+L+ G ++++D GLA FS K P+ V T Y PE Sbjct: 307 HMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKK---PH---ASVGTHGYMAPE 360 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMW-TRSPIMQGNT-EQHQ-----LALISQLCGSITPE 251 +L Y D + GC++ ++ SP Q T ++H+ L + +L S +PE Sbjct: 361 VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE 420 Query: 252 V 252 + Sbjct: 421 L 421 >4M66-A nrPDB Length = 325 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/157 (33%), Positives = 89/157 (56%), Gaps = 15/157 (9%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 + +KL +G+G FG VF+A HR VA+K ++ ++K + E+K + L++EN Sbjct: 21 ELKKLEFVGKGGFGVVFRAHHRTWNHDVAVK--IVNSKKISW------EVKAMVNLRNEN 72 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 V+ L+ + T+ ++ G LV F E+ LAGLL + + R++Q ++ G Sbjct: 73 VLLLLGV--TEDLQWDFVSGQA-LVTRFMENGSLAGLLQPEAPR-PWPLLCRLLQEVVLG 128 Query: 137 LYYIHR--NKILHRDMKAANVLITRDGVLKLADFGLA 171 + Y+H +LHRD+K +N+L+ + KLADFGL+ Sbjct: 129 MCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLS 165 >4UYA-A nrPDB Length = 340 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 105/221 (47%), Gaps = 47/221 (21%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI--TALREIKILQLLKHENVVNLI 82 IG G FG+V++A + GQ+VA+K + E++ + RE ++ +L+H N++ L Sbjct: 34 IGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELR 91 Query: 83 EICRTKASPYNRCKGSIYLVFDFCE-----HDLAG--LLSNVLVKFTLSEIKRVMQMLLN 135 +C + P+ + LV +F LAG + +VLV + + +I R Sbjct: 92 GVCLQQ--PH------LCLVLEFARGGALNRALAGRRIPPHVLVNWAV-QIAR------- 135 Query: 136 GLYYIHRNK---ILHRDMKAANVL----ITRDGV----LKLADFGLARAFS-LAKNSQPN 183 G+ Y+H ILHRD+K++N+L I D + LK+ DFGLAR + K + Sbjct: 136 GMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAG 195 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 Y W P ++ + D+W G ++ E+ T Sbjct: 196 AYA------WMAPE--VIKSSLFSKGSDIWSYGVLLWELLT 228 >1FVR-A nrPDB Length = 327 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 47/168 (27%), Positives = 81/168 (48%), Gaps = 28/168 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKV--ALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 IG+G FG+V KAR +K G ++ A+K++ K+ A + +L H N++NL+ Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEH---------------DLAGLLSNVLVKFTLS--E 125 C + G +YL ++ H D A ++N TLS + Sbjct: 93 GACEHR--------GYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS-TLSSQQ 143 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA 173 + + G+ Y+ + + +HRD+ A N+L+ + V K+ADFGL+R Sbjct: 144 LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG 191 >5HIE-A nrPDB Length = 302 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 95/203 (46%), Gaps = 20/203 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 +IG G+FG V+K K VA+K +L + + F E+ +L+ +H N++ + Sbjct: 43 RIGSGSFGTVYKG---KWHGDVAVK-MLTPQQLQAFK----NEVGVLRKTRHVNILLFMG 94 Query: 84 ICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142 K + +V +CE L L + KF + ++ + + G+ Y+H Sbjct: 95 YS---------TKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA 145 Query: 143 NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG 202 I+HRD+K+ N+ + D +K+ DFGLA S S + + LW P + + Sbjct: 146 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSI-LWMAPEVIRMQ 204 Query: 203 ERD-YGPPIDLWGAGCIMAEMWT 224 +++ Y D++ G ++ E+ T Sbjct: 205 DKNPYSFQSDVYAFGIVLYELMT 227 >3A8W-A nrPDB Length = 345 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 95/217 (43%), Gaps = 18/217 (8%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME--NEKEGFPITALREIKILQLL 73 + ++ L IG+G++ +V R +KT + A+K V E N+ E + Q Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H +V L +T++ ++ V ++ K + + Sbjct: 68 NHPFLVGLHSCFQTESR--------LFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEI 119 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TL 192 L Y+H I++RD+K NVL+ +G +KL D+G+ + + +P T+ T Sbjct: 120 SLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK-----EGLRPGDTTSTFCGTP 174 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPI 228 Y PE+L GE DYG +D W G +M EM RSP Sbjct: 175 NYIAPEILRGE-DYGFSVDWWALGVLMFEMMAGRSPF 210 >4PDO-A nrPDB Length = 299 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 93/205 (45%), Gaps = 16/205 (7%) Query: 25 IGQGTFGEVFKARHRKTGQK----VALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 IG G FGEV+K + + K VA+K L E + L E I+ H N++ Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIK-TLKAGYTEKQRVDFLGEAGIMGQFSHHNIIR 100 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYY 139 L E +K P + ++ ++ E+ L L +F++ ++ +++ + G+ Y Sbjct: 101 L-EGVISKYKP-------MMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 152 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + +HRD+ A N+L+ + V K++DFGL+R + ++ W P Sbjct: 153 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEA- 211 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWT 224 + R + D+W G +M E+ T Sbjct: 212 -ISYRKFTSASDVWSFGIVMWEVMT 235 >3SOC-A nrPDB Length = 322 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/235 (26%), Positives = 106/235 (45%), Gaps = 42/235 (17%) Query: 26 GQGTFGEVFKARHRKTGQKVALK------KVLMENEKEGFPITALREIKILQLLKHENVV 79 +G FG V+KA+ + VA+K K +NE E + + ++ ILQ + E Sbjct: 33 ARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRG 90 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLLNGL 137 +++ ++L+ F E G LS+ L +S E+ + + + GL Sbjct: 91 TSVDV-------------DLWLITAFHE---KGSLSDFLKANVVSWNELCHIAETMARGL 134 Query: 138 YYIHRN----------KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 Y+H + I HRD+K+ NVL+ + +ADFGLA F K++ Sbjct: 135 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTH--G 192 Query: 188 RVVTLWYRPPELLLG----ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 +V T Y PE+L G +RD ID++ G ++ E+ +R G +++ L Sbjct: 193 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYML 247 >5KMM-A nrPDB Length = 329 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 115/247 (46%), Gaps = 46/247 (18%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKAR-HRKTGQK----VALK--KVLMENEKEGFPITALRE 66 D V K+E +G+G FG+VF A H ++ VA+K K E+ ++ F RE Sbjct: 36 DIVLKWE----LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ----RE 87 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD---------------LA 111 ++L +L+H+++V +C T+ P + +VF++ H LA Sbjct: 88 AELLTMLQHQHIVRFFGVC-TEGRP-------LLMVFEYMRHGDLNRFLRSHGPDAKLLA 139 Query: 112 GLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171 G L ++ V + G+ Y+ +HRD+ N L+ + V+K+ DFG++ Sbjct: 140 GGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMS 199 Query: 172 RAFSLAKNSQPNRYTNR-VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT--RSPI 228 R ++ R R ++ + + PPE +L R + D+W G ++ E++T + P Sbjct: 200 RDIY---STDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPW 255 Query: 229 MQ-GNTE 234 Q NTE Sbjct: 256 YQLSNTE 262 >2JD5-A nrPDB Length = 373 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 83/348 (23%), Positives = 144/348 (41%), Gaps = 74/348 (21%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P+ D ++Y + K+G G F V+ A+ VA+K V + + + A EIK+L Sbjct: 15 PYKD--ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGD---KVYTEAAEDEIKLL 69 Query: 71 QLLK-----HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEHDLAGLLSNVLVK-FT 122 Q + E+ + I + ++ ++ +VF+ +L L+ + Sbjct: 70 QRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIP 129 Query: 123 LSEIKRVMQMLLNGLYYIHRN-KILHRDMKAANVLITRDGV------LKLADFGLARAFS 175 L +K++ + LL GL Y+HR I+H D+K NVL+ +K+AD G A + Sbjct: 130 LIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD 189 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN--- 232 YTN + T YR PE+LLG +G D+W C++ E+ T + + + Sbjct: 190 -------EHYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGH 241 Query: 233 ---TEQHQLALISQLCGSITP-------------------------EVWPNVDNYELYEK 264 + +A I +L G + + WP D L EK Sbjct: 242 SYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLED--VLTEK 299 Query: 265 LELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 + K + +++ D + +L LDP +R D+ +NH Sbjct: 300 YKFSKDEAKEIS-------------DFLSPMLQLDPRKRADAGGLVNH 334 >5U6C-A nrPDB Length = 315 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 65/252 (25%), Positives = 103/252 (40%), Gaps = 35/252 (13%) Query: 22 LAKI-GQGTFGEVFKARHRK---TGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 L KI G+G FG V + ++ T KVA+K + ++N + L E ++ H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVF----DFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 V+ L+ +C + S K + L F D + L L L + + M + Sbjct: 100 VMRLLGVC-IEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ LHRD+ A N ++ D + +ADFGL++ + R V W Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK-W 217 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 L +R Y D+W G M E+ TR +TP + Sbjct: 218 IAIES--LADRVYTSKSDVWAFGVTMWEIATR---------------------GMTP--Y 252 Query: 254 PNVDNYELYEKL 265 P V N+E+Y+ L Sbjct: 253 PGVQNHEMYDYL 264 >4R7H-A nrPDB Length = 343 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 108/232 (46%), Gaps = 47/232 (20%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLME--------NEKEGFPITALREIKIL-QLLKH 75 +G G FG+V +A G++ A+ KV ++ +EKE + E+KI+ L +H Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 113 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL---SNVLVKFTLS------- 124 EN+VNL+ C T P + ++ ++C + DL L + ++ +LS Sbjct: 114 ENIVNLLGAC-THGGP-------VLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEG 165 Query: 125 ---------EIKRVMQM---LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 E++ ++ + G+ ++ +HRD+ A NVL+T V K+ DFGLAR Sbjct: 166 LDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLAR 225 Query: 173 AFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + ++ + R+ W P + + Y D+W G ++ E+++ Sbjct: 226 DI-MNDSNYIVKGNARLPVKWMAPESIF--DSVYTVQSDVWSYGILLWEIFS 274 >4PWN-A nrPDB Length = 274 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 134/304 (44%), Gaps = 61/304 (20%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKV----LMENEKEGFPITALREIKILQLLKHENVV 79 +IG+G+F V+K +T +VA ++ L ++E++ F E ++L+ L+H N+V Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFK----EEAEMLKGLQHPNIV 72 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV---MQMLLNG 136 + + + K I LV + +G L L +F + +IK + + +L G Sbjct: 73 RFYDSWESTV----KGKKCIVLVTELM---TSGTLKTYLKRFKVMKIKVLRSWCRQILKG 125 Query: 137 LYYIHRNK--ILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TL 192 L ++H I+HRD+K N+ IT G +K+ D GLA +L K + + V+ T Sbjct: 126 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLEKRAS---FAKSVIGTP 179 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPE 251 + PE+ E Y +D++ G M EM T P + Q+ + ++ + P Sbjct: 180 EFMAPEMY--EEKYDESVDVYAFGMCMLEMATSEYPYSEC---QNAAQIYRRVTSGVKP- 233 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + D + E E+++G R+ KD +R D LN Sbjct: 234 --ASFDKVAIPEVKEIIEGCIRQNKD------------------------ERYSIKDLLN 267 Query: 312 HDFF 315 H FF Sbjct: 268 HAFF 271 >2QKW-B nrPDB Length = 321 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 112/234 (47%), Gaps = 22/234 (9%) Query: 5 YDSVECPFCD---EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 ++S P D + ++ IG G FG+V+K R G KVALK+ E+ + Sbjct: 24 FESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLRD-GAKVALKRRTPESSQG--IE 80 Query: 62 TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD--LAGLLSNVLV 119 EI+ L +H ++V+LI C + + L++ + E+ L + L Sbjct: 81 EFETEIETLSFCRHPHLVSLIGFCDER--------NEMILIYKYMENGNLKRHLYGSDLP 132 Query: 120 KFTLSEIKRVMQML--LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 ++S +R+ + GL+Y+H I+HRD+K+ N+L+ + V K+ DFG+++ + Sbjct: 133 TMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGT-- 190 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAE-MWTRSPIMQ 230 + Q + T TL Y PE + R D++ G ++ E + RS I+Q Sbjct: 191 ELDQTHLSTVVKGTLGYIDPEYFIKGR-LTEKSDVYSFGVVLFEVLCARSAIVQ 243 >3KRL-A nrPDB Length = 335 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/225 (24%), Positives = 101/225 (44%), Gaps = 40/225 (17%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLME--------NEKEGFPITALREIKIL-QLLKH 75 +G G FG+V +A G++ A+ KV ++ +EKE + E+KI+ L +H Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 109 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL---------------SNVLV 119 EN+VNL+ C G + ++ ++C + DL L N Sbjct: 110 ENIVNLLGACTHG--------GPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEE 161 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 + + ++ + G+ ++ +HRD+ A NVL+T V K+ DFGLAR + + Sbjct: 162 QLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MNDS 220 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + + R+ W P + + Y D+W G ++ E+++ Sbjct: 221 NYIVKGNARLPVKWMAPESIF--DCVYTVQSDVWSYGILLWEIFS 263 >1LUF-A nrPDB Length = 343 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 96/229 (41%), Gaps = 31/229 (13%) Query: 20 EKLAKIGQGTFGEVFKARH-----RKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 E + IG+G FG VF+AR + VA+K +L E RE ++ Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVK-MLKEEASADMQADFQREAALMAEFD 108 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR------ 128 + N+V L+ +C C Y+ + L + + + + S++ Sbjct: 109 NPNIVKLLGVCAVGKP---MCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSS 165 Query: 129 -------------VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS 175 + + + G+ Y+ K +HRD+ N L+ + V+K+ADFGL+R Sbjct: 166 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 225 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 A + + N + + + PPE + R Y D+W G ++ E+++ Sbjct: 226 SADYYKAD--GNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFS 271 >2ZMD-A nrPDB Length = 390 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 87/316 (27%), Positives = 133/316 (42%), Gaps = 70/316 (22%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH--E 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLL 134 ++ L + Y IY+V + DL L K ++ E K + +L Sbjct: 117 KIIRLYD--------YEITDQYIYMVMECGNIDLNSWLKK---KKSIDPWERKSYWKNML 165 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF-----SLAKNSQPNRYTNRV 189 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S+ K+SQ V Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-------V 217 Query: 190 VTLWYRPPEL---LLGERDYG-------PPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQL 238 + Y PPE + R+ G P D+W GCI+ M + ++P Q + Sbjct: 218 GAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQII 271 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 IS+L I P N+E +E ++ ++D LK L Sbjct: 272 NQISKLHAIIDP-------NHE----IEFPDIPEKDLQDVLKC-------------CLKR 307 Query: 299 DPAQRIDSDDALNHDF 314 DP QRI + L H + Sbjct: 308 DPKQRISIPELLAHPY 323 >3HDN-A nrPDB Length = 373 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/227 (27%), Positives = 105/227 (46%), Gaps = 26/227 (11%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKT----GQKVALKKVLMENEKEGFPITALREIKILQL 72 S + L IG+G+FG+V ARH+ KV KK +++ ++E I + R + +L+ Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKH-IMSERNV-LLKN 95 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRV 129 +KH +V L +T +Y V D+ G L L + F + Sbjct: 96 VKHPFLVGLHFSFQTA--------DKLYFVLDYIN---GGELFYHLQRERCFLEPRARFY 144 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + + L Y+H I++RD+K N+L+ G + L DFGL + ++ NS + + Sbjct: 145 AAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE-NIEHNSTTSTFCG-- 201 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQ 235 T Y PE +L ++ Y +D W G ++ EM + P NT + Sbjct: 202 -TPEYLAPE-VLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAE 246 >5C26-A nrPDB Length = 299 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 90/206 (43%), Gaps = 19/206 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE--GFPITALREIKILQLLKHENVVNL 81 ++G G FG V K ++ + +++NE L E ++Q L + +V + Sbjct: 34 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 93 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLY 138 I IC + S LV + E G L+ L + + K +++++ G+ Sbjct: 94 IGICEAE---------SWMLVMEMAE---LGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 141 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y+ + +HRD+ A NVL+ K++DFGL++A +N + + WY P Sbjct: 142 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE- 200 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWT 224 + + D+W G +M E ++ Sbjct: 201 -CINYYKFSSKSDVWSFGVLMWEAFS 225 >3DB8-A nrPDB Length = 317 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 88/226 (38%), Gaps = 37/226 (16%) Query: 99 IYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT 158 +Y+V + C L T E + M+ + G+ Y+H N+++HRD+K N+ + Sbjct: 117 VYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLN 176 Query: 159 RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI 218 D +K+ DFGLA R + T Y PE+L ++ + +D+W GCI Sbjct: 177 DDMDVKIGDFGLATKIEF----DGERKKDLCGTPNYIAPEVLC-KKGHSFEVDIWSLGCI 231 Query: 219 MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 + + P + + L E +K + V Sbjct: 232 LYTLLVGKPPFETSC---------------------------LKETYIRIKKNEYSVPRH 264 Query: 279 LKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDL 324 + +P A LI ++L DP R + L +FF S P L Sbjct: 265 I-----NPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRL 305 >4FR4-A nrPDB Length = 384 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 94/214 (43%), Gaps = 30/214 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLL 73 +E L IG+G+FG+V + T + A+K K + NE +E++I+Q L Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRN----VFKELQIMQGL 72 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIKRVM 130 +H +VNL + + +++V D L G L L V F +K + Sbjct: 73 EHPFLVNLWYSFQDEED--------MFMVVDLL---LGGDLRYHLQQNVHFKEETVKLFI 121 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L+ L Y+ +I+HRDMK N+L+ G + + DF +A L + +Q T Sbjct: 122 CELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAM--LPRETQ---ITTMAG 176 Query: 191 TLWYRPPELLLGER--DYGPPIDLWGAGCIMAEM 222 T Y PE+ + Y +D W G E+ Sbjct: 177 TKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYEL 210 >4YHJ-A nrPDB Length = 584 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 96/202 (47%), Gaps = 19/202 (9%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF-PITALREIKILQLLKHENVVNLIE 83 +G+G FGEV + R TG+ A KK+ + K+ AL E +IL+ ++ VV+L Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM--LLNGLYYI 140 TK ++ LV DL + N L E + V L GL + Sbjct: 253 AYETK--------DALCLVLTIMNGGDLKFHIYN-LGNPGFDEQRAVFYAAELCCGLEDL 303 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 R +I++RD+K N+L+ G ++++D GLA + R RV T+ Y PE++ Sbjct: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATEI-----PEGQRVRGRVGTVGYMAPEVV 358 Query: 201 LGERDYGPPIDLWGAGCIMAEM 222 E+ P D WG GC++ EM Sbjct: 359 NNEKYTFSP-DWWGLGCLIYEM 379 >4FL3-A nrPDB Length = 635 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 90/206 (43%), Gaps = 19/206 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE--GFPITALREIKILQLLKHENVVNL 81 ++G G FG V K ++ + +++NE L E ++Q L + +V + Sbjct: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLY 138 I IC + S LV + E G L+ L + + K +++++ G+ Sbjct: 436 IGICEAE---------SWMLVMEMAE---LGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y+ + +HRD+ A NVL+ K++DFGL++A +N + + WY P Sbjct: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE- 542 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWT 224 + + D+W G +M E ++ Sbjct: 543 -CINYYKFSSKSDVWSFGVLMWEAFS 567 >2Y4I-B nrPDB Length = 319 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 44/168 (26%), Positives = 85/168 (50%), Gaps = 20/168 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 IG+G FG+V+ H + +VA++ + +E + E RE+ + +HENVV + Sbjct: 41 IGKGRFGQVY---HGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGA 97 Query: 85 CRTK---ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIH 141 C + A + CKG L ++ + + +++ +++ Q ++ G+ Y+H Sbjct: 98 CMSPPHLAIITSLCKGRT----------LYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLH 147 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 ILH+D+K+ NV +G + + DFGL FS++ Q R +++ Sbjct: 148 AKGILHKDLKSKNVFYD-NGKVVITDFGL---FSISGVLQAGRREDKL 191 >5AMN-A nrPDB Length = 299 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 90/214 (42%), Gaps = 25/214 (11%) Query: 25 IGQGTFGEVFKAR----HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 +G+G FG+V KA + G K+L EN L E +L+ + H +V+ Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 90 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV---------KFTLSEIKRVM 130 L C G + L+ ++ ++ L G L T+ ++ Sbjct: 91 LYGACSQD--------GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFA 142 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + G+ Y+ K++HRD+ A N+L+ +K++DFGL+R ++S R R+ Sbjct: 143 WQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSYVKRSQGRIP 201 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 W L + Y D+W G ++ E+ T Sbjct: 202 VKWMAIESLF--DHIYTTQSDVWSFGVLLWEIVT 233 >3OMV-A nrPDB Length = 307 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 97/214 (45%), Gaps = 19/214 (8%) Query: 15 EVSKYEKLAKIGQGTFGEVFKAR-HRKTGQKVALKKVLMENEKEGFPITALR-EIKILQL 72 E S+ +IG G+FG V+K + H K+ LK V E+ A R E+ +L+ Sbjct: 34 EASEVMLSTRIGSGSFGTVYKGKWHGDVAVKI-LKVVDPTPEQ----FQAFRNEVAVLRK 88 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQ 131 +H N++ + K ++ +V +CE L L KF + ++ + + Sbjct: 89 TRHVNILLFMGYM---------TKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIAR 139 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 G+ Y+H I+HRDMK+ N+ + +K+ DFGLA S SQ V Sbjct: 140 QTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSV- 198 Query: 192 LWYRPPELLLGERD-YGPPIDLWGAGCIMAEMWT 224 LW P + + + + + D++ G ++ E+ T Sbjct: 199 LWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT 232 >1FOT-A nrPDB Length = 318 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/233 (23%), Positives = 102/233 (43%), Gaps = 44/233 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIK------- 68 + ++ L +G G+FG V R R G+ A+K + E + L++++ Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKE------IVVRLKQVEHTNDERL 58 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL------SNVLVKF 121 +L ++ H ++ + + I+++ D+ E +L LL N + KF Sbjct: 59 MLSIVTHPFIIRMWGTFQDAQQ--------IFMIMDYIEGGELFSLLRKSQRFPNPVAKF 110 Query: 122 TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 +E+ ++ Y+H I++RD+K N+L+ ++G +K+ DFG A+ Sbjct: 111 YAAEVCLALE-------YLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV------- 156 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNT 233 P+ T Y PE ++ + Y ID W G ++ EM +P NT Sbjct: 157 PDVTYTLCGTPDYIAPE-VVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNT 208 >6E9W-A nrPDB Length = 443 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 89/210 (42%), Gaps = 20/210 (9%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE--KEGFPITALREIKILQLLKHE 76 YE + IG+G FGEV RH+ T +KV K+L + E K E I+ Sbjct: 104 YEVVKVIGRGAFGEVQLVRHKST-RKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 162 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLN 135 VV L + +Y+V ++ DL L+SN V + +L Sbjct: 163 WVVQLFYAFQDDRY--------LYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVL-- 212 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L IH +HRD+K N+L+ + G LKLADFG + K R V T Y Sbjct: 213 ALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGT--CMKMNKEGMV-RCDTAVGTPDYI 269 Query: 196 PPELLL---GERDYGPPIDLWGAGCIMAEM 222 PE+L G+ YG D W G + EM Sbjct: 270 SPEVLKSQGGDGYYGRECDWWSVGVFLYEM 299 >3V5Q-A nrPDB Length = 297 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/233 (24%), Positives = 109/233 (46%), Gaps = 33/233 (14%) Query: 24 KIGQGTFGEVFKARHRK---TGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 ++G+G FG+VF A T K+ + +++ RE ++L L+HE++V Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVK 81 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL------SNVLV---------KFTLS 124 +C P + +VF++ +H DL L + +LV + LS Sbjct: 82 FYGVC-GDGDP-------LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLS 133 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 ++ + + +G+ Y+ +HRD+ N L+ + ++K+ DFG++R + Sbjct: 134 QMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGG 193 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT--RSPIMQ-GNTE 234 +T ++ + + PPE ++ R + D+W G I+ E++T + P Q NTE Sbjct: 194 HT--MLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTE 243 >3NYO-A nrPDB Length = 576 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 96/210 (45%), Gaps = 18/210 (8%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF-PITALREIKILQLLKHENVVNLIE 83 +G+G FGEV + R TG+ A KK+ + K+ AL E +IL+ + VV+L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM--LLNGLYYIH 141 TK ++ LV + + E + V + GL +H Sbjct: 252 AYETK--------DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 R +I++RD+K N+L+ G ++++D GLA + + RV T+ Y PE++ Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-----GRVGTVGYMAPEVVK 358 Query: 202 GERDYGPPIDLWGAGCIMAEMWT-RSPIMQ 230 ER P D W GC++ EM +SP Q Sbjct: 359 NERYTFSP-DWWALGCLLYEMIAGQSPFQQ 387 >3C51-A nrPDB Length = 543 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 99/208 (47%), Gaps = 28/208 (13%) Query: 25 IGQGTFGEVFKARHRKTGQKVAL--KKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 +G+G FGEVF + + TG+ A +++G+ A+ E KIL + +V+L Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQ-GAMVEKKILAKVHSRFIVSLA 251 Query: 83 EICRTKASPYNRC-------KGSI-YLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 TK + C G I Y +++ + D G + +T ++ Sbjct: 252 YAFETKT---DLCLVMTIMNGGDIRYHIYN-VDEDNPGFQEPRAIFYT--------AQIV 299 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 +GL ++H+ I++RD+K NVL+ DG ++++D GLA A ++ Y T + Sbjct: 300 SGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELK-AGQTKTKGYAG---TPGF 355 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEM 222 PELLLGE +Y +D + G + EM Sbjct: 356 MAPELLLGE-EYDFSVDYFALGVTLYEM 382 >3ALO-A nrPDB Length = 327 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 76/288 (26%), Positives = 121/288 (42%), Gaps = 44/288 (15%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L +IG+G +G V K H+ +GQ +A+K++ + + E + QLL +VV Sbjct: 27 LGEIGRGAYGSVNKMVHKPSGQIMAVKRIR----------STVDEKEQKQLLMDLDVVMR 76 Query: 82 IEICRTKASPYNR---------CKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 C Y C + FD + +L +V+ + L +I Sbjct: 77 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK 136 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQPNRYTNRVV 190 LN L KI+HRD+K +N+L+ R G +KL DFG++ S+AK T Sbjct: 137 ALNHLK--ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAK-------TRDAG 187 Query: 191 TLWYRPPELL---LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI----- 241 Y PE + + Y D+W G + E+ T R P + N+ QL + Sbjct: 188 CRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDP 247 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL 289 QL S E P+ N + L L K + ++ K K ++ P+ L Sbjct: 248 PQLSNSEEREFSPSFIN---FVNLCLTKDESKRPK--YKELLKHPFIL 290 >5IKW-A nrPDB Length = 310 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 101/226 (44%), Gaps = 34/226 (15%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLL 73 +V+ E LA +G F VF R G + ALK++ + N + REI I+ +L Sbjct: 15 QVTLEESLA---EGGFSTVFLVRTHG-GIRCALKRMYVNNMPD--LNVCKREITIMKELS 68 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-----FTLSEIKR 128 H+N+V ++ N +++ V E+ AG + N + K FT E+ + Sbjct: 69 GHKNIVGYLD------CAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQ 122 Query: 129 VMQMLLNGLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + + +H+ K I+HRD+K N+L+ G L DFG A K P + Sbjct: 123 IFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSAT----NKFLNPQKDG 178 Query: 187 NRVV--------TLWYRPPEL--LLGERDYGPPIDLWGAGCIMAEM 222 VV TL YR PE+ L G + D+W GC++ ++ Sbjct: 179 VNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >6BDL-A nrPDB Length = 347 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 96/224 (42%), Gaps = 26/224 (11%) Query: 15 EVSKYEKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 ++S + + +G G FG V K+ KT LKK + + ++ I + E +I+ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRS--EKQIM 89 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIK 127 Q + +V L K S Y +Y++ + C L G L +L F S + Sbjct: 90 QGAHSDFIVRLYRTF--KDSKY------LYMLMEAC---LGGELWTILRDRGSFEDSTTR 138 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 ++ Y+H I++RD+K N+++ G KL DFG A+ K + Sbjct: 139 FYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW-----T 193 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 T Y PE++L + + D W G +M E+ T SP G Sbjct: 194 FCGTPEYVAPEIIL-NKGHDISADYWSLGILMYELLTGSPPFSG 236 >3C1X-A nrPDB Length = 373 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 95/210 (45%), Gaps = 21/210 (10%) Query: 25 IGQGTFGEVFKARHRKT-GQKV-----ALKKVLMENEKEGFPITALREIKILQLLKHENV 78 IG+G FG V+ G+K+ +L ++ E F L E I++ H NV Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQF----LTEGIIMKDFSHPNV 152 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 ++L+ IC R +GS +V + +H DL + N T+ ++ + G+ Sbjct: 153 LSLLGICL-------RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 205 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR-AFSLAKNSQPNRYTNRVVTLWYRP 196 ++ K +HRD+ A N ++ +K+ADFGLAR + +S N+ ++ W Sbjct: 206 KFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMAL 265 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 L + + D+W G ++ E+ TR Sbjct: 266 ES--LQTQKFTTKSDVWSFGVLLWELMTRG 293 >6CKI-A nrPDB Length = 316 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 76/301 (25%), Positives = 126/301 (41%), Gaps = 38/301 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHENVVNLIE 83 +G+G V + T Q+ A+K ++E + RE+++L Q H NV+ L Sbjct: 21 LGEGAHARVQTCINLITSQEYAVK--IIEKQPGHIRSRVFREVEMLYQCQGHRNVLEL-- 76 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR--VMQMLLNGLYYIH 141 +R YLVF+ + +LS++ + +E++ V+Q + + L ++H Sbjct: 77 --IEFFEEEDR----FYLVFE--KMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH 128 Query: 142 RNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV---TLWYR 195 I HRD+K N+L + +K+ DFGL L + P + + Y Sbjct: 129 NKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYM 188 Query: 196 PPELLLGERD----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 PE++ + Y DLW G I+ + + P G CG E Sbjct: 189 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CGWDRGE 240 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 P N L+E ++ K + D+ A++ A DLI KLLV D QR+ + L Sbjct: 241 ACPACQNM-LFES---IQEGKYEFPDKDWAHI-SCAAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 312 H 312 H Sbjct: 296 H 296 >6GQK-A nrPDB Length = 328 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 90/224 (40%), Gaps = 38/224 (16%) Query: 25 IGQGTFGEVFKARHR-----KTGQKVA---LKKVLMENEKEGFPITALREIKILQLL-KH 75 +G G FG+V +A + VA LK E+E + E+K+L L H Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREAL----MSELKVLSYLGNH 104 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF-------------- 121 EN+VNL+ C T P ++ + C DL L +F Sbjct: 105 ENIVNLLGAC-THGGP------TLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDF 157 Query: 122 -TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 TL + + G+ ++ +HRD+ A N+L+T + K+ DFGLAR N Sbjct: 158 LTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNY 217 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 ++ R+ W P + Y D+W G + E+++ Sbjct: 218 V-DKGNARLPVKWMAPESIF--NSVYTFESDVWSYGIFLWELFS 258 >3MY0-A nrPDB Length = 305 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 76/296 (25%), Positives = 125/296 (42%), Gaps = 51/296 (17%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 +A+Q VEC +G+G +GEV++ G+ VA+K +E+ F Sbjct: 6 VARQVALVEC--------------VGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFR 49 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 T EI LL+H+N++ I T + + ++L+ + EH G L + L + Sbjct: 50 ET---EIYNTVLLRHDNILGFIASDMTSRNSSTQ----LWLITHYHEH---GSLYDFLQR 99 Query: 121 FTLSE--IKRVMQMLLNGLYYIH--------RNKILHRDMKAANVLITRDGVLKLADFGL 170 TL R+ GL ++H + I HRD K+ NVL+ + +AD GL Sbjct: 100 QTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGL 159 Query: 171 ARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE-----RDYGPPIDLWGAGCIMAEMWTR 225 A S + RV T Y PE+L + + D+W G ++ E+ R Sbjct: 160 AVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEI-AR 218 Query: 226 SPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKA 281 I+ G E ++ +V PN ++E +K+ V Q + +RL A Sbjct: 219 RTIVNGIVEDYRPPFY---------DVVPNDPSFEDMKKVVCVDQQTPTIPNRLAA 265 >5HLW-A nrPDB Length = 299 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 95/209 (45%), Gaps = 19/209 (9%) Query: 25 IGQGTFGEVFKARHRKT-GQKV-----ALKKVLMENEKEGFPITALREIKILQLLKHENV 78 IG+G FG V+ G+K+ +L ++ E F L E I++ H NV Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQF----LTEGIIMKDFSHPNV 83 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 ++L+ IC R +GS +V + +H DL + N T+ ++ + G+ Sbjct: 84 LSLLGICL-------RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 136 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ K +HRD+ A N ++ +K+ADFGLAR + + T + + + Sbjct: 137 KYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMAL 196 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 E L ++ + D+W G ++ E+ TR Sbjct: 197 ESLQTQK-FTTKSDVWSFGVLLWELMTRG 224 >6ED6-A nrPDB Length = 415 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 64/215 (29%), Positives = 89/215 (41%), Gaps = 30/215 (13%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE--KEGFPITALREIKILQLLKHE 76 Y+ + IG+G FGEV RH K QKV K+L + E K E I+ Sbjct: 90 YDVVKVIGRGAFGEVQLVRH-KASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 148 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV-----KFTLSEIKRVM 130 VV L + +Y+V ++ DL L+SN V KF +E+ + Sbjct: 149 WVVQLFYAFQDDRY--------LYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLAL 200 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 IH ++HRD+K N+L+ + G LKLADFG + V Sbjct: 201 DA-------IHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCD---TAVG 250 Query: 191 TLWYRPPELLL---GERDYGPPIDLWGAGCIMAEM 222 T Y PE+L G+ YG D W G + EM Sbjct: 251 TPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEM 285 >2WTK-B nrPDB Length = 373 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 81/340 (23%), Positives = 132/340 (38%), Gaps = 58/340 (17%) Query: 12 FCDEVSKYEKLAKIGQG--TFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI 69 F E YE L IG+G V AR++ TG+ V ++++ +E E+ + Sbjct: 4 FLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHV 63 Query: 70 LQLLKHENVVNLIEICRTKASPYNR---CKGSIYLVFDF----------CEHDLAGLLSN 116 +L H N+V PY +++V F C H + G+ N Sbjct: 64 SKLFNHPNIV-----------PYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGM--N 110 Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 L I ++Q +L L YIH +HR +KA+++LI+ DG + L+ GL S+ Sbjct: 111 ELA------IAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSM 162 Query: 177 AKNSQPNR-------YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM------W 223 + Q R Y+ +V+ W P L + Y D++ G E+ + Sbjct: 163 ISHGQRQRVVHDFPKYSVKVLP-WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPE----VWP--NVDNYELYEKLELVKGQKRKVKD 277 P Q E+ + L S P + P +V N L + L + Sbjct: 222 KDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDS 281 Query: 278 RLKAYVR--DPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 Y R P+ +++ L +P R + LNH FF Sbjct: 282 PSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFF 321 >5O2C-A nrPDB Length = 380 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 73/306 (23%), Positives = 129/306 (42%), Gaps = 60/306 (19%) Query: 24 KIGQGTFGEVFKARHRKTGQKVAL----KKVLMENEKEGFPITALREIKILQLLKHENVV 79 ++G+G F V+K +T +VA + L + E++ F E ++L+ L+H N+V Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFK----EEAEMLKGLQHPNIV 87 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNG 136 + + + K I LV + +G L L +F + + ++ + +L G Sbjct: 88 RFYDSWES----ILKGKKCIVLVTELM---TSGTLKTYLKRFKVMKPKVLRSWCRQILKG 140 Query: 137 LYYIHRNK--ILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TL 192 L ++H I+HRD+K N+ IT G +K+ D GLA +L + S + V+ T Sbjct: 141 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLMRTS----FAKSVIGTP 193 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 + PE+ E Y +D++ G M EM T + +Q+ +T + Sbjct: 194 EFMAPEMY--EEHYDESVDVYAFGMCMLEMAT------SEYPYSECQNAAQIYRKVTSGI 245 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 P N V DP ++I+ + + ++R+ D LNH Sbjct: 246 KPASFN-----------------------KVTDPEVKEIIEGCIRQNKSERLSIRDLLNH 282 Query: 313 DFFWSD 318 FF D Sbjct: 283 AFFAED 288 >5O2B-A nrPDB Length = 285 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 74/306 (24%), Positives = 130/306 (42%), Gaps = 60/306 (19%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKV----LMENEKEGFPITALREIKILQLLKHENVV 79 ++G+G F V+K +T +VA ++ L + E++ F E ++L+ L+H N+V Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFK----EEAEMLKGLQHPNIV 78 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNG 136 + S + KG +V E +G L L +F + + ++ + +L G Sbjct: 79 RFYD------SWESILKGKKCIVL-VTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKG 131 Query: 137 LYYIHRNK--ILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRYTNRVV-TL 192 L ++H I+HRD+K N+ IT G +K+ D GLA +L + S + V+ T Sbjct: 132 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLMRTS----FAKSVIGTP 184 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 + PE+ E Y +D++ G M EM T + +Q+ +T + Sbjct: 185 EFMAPEMY--EEHYDESVDVYAFGMCMLEMAT------SEYPYSECQNAAQIYRKVTSGI 236 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 P N V DP ++I+ + + ++R+ D LNH Sbjct: 237 KPASFN-----------------------KVTDPEVKEIIEGCIRQNKSERLSIRDLLNH 273 Query: 313 DFFWSD 318 FF D Sbjct: 274 AFFAED 279 >5XD6-A nrPDB Length = 305 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 105/227 (46%), Gaps = 26/227 (11%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D Y + IG+G++G VF K+G+ A+KK+ + + L ++ ++ L Sbjct: 19 DITDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQ---EFLAQVSMVSRL 74 Query: 74 KHENVVNLIEIC-----RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR 128 + ENVV L+ C R A Y GS++ + H G+ LS +R Sbjct: 75 RQENVVALLGYCVDGPLRVLAYEY-APNGSLHDIL----HGRKGV-KGAQPGPVLSWHQR 128 Query: 129 VMQML--LNGLYYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 V + GL Y+H ++HRD+K++NVL+ D V K+ADF L+ A + Sbjct: 129 VKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQ---APDMAAR 185 Query: 184 RYTNRVV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPI 228 ++ RV+ T Y PE + D++ G ++ E+ T R P+ Sbjct: 186 LHSTRVLGTFGYHAPEYAM-TGTLSTKSDVYSFGVVLLELLTGRKPV 231 >6BXI-A nrPDB Length = 333 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 110/273 (40%), Gaps = 53/273 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKV----LMENEKEGFPITALREIKILQLLK 74 +E L IG+G FGEV + + TG A+K + ++E E+ G I A R+I Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGH-IRAERDI------- 59 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQ 131 +V + K + K ++YL+ +F G + +L+K T E + + Sbjct: 60 ---LVEADSLWVVKMFYSFQDKLNLYLIMEFLP---GGDMMTLLMKKDTLTEEETQFYIA 113 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA---------KNSQP 182 + + IH+ +HRD+K N+L+ G +KL+DFGL A +S P Sbjct: 114 ETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLP 173 Query: 183 NRYT------NRVVTLWYRPPELL----LGERDYGPP-----------IDLWGAGCIMAE 221 + +T R W R L +G DY P D W G IM E Sbjct: 174 SDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYE 233 Query: 222 MWTRSPIMQGNTEQHQLALISQLCGSIT--PEV 252 M P T Q + ++T PEV Sbjct: 234 MLIGYPPFCSETPQETYKKVMNWKETLTFPPEV 266 >5GNK-A nrPDB Length = 297 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 90/211 (42%), Gaps = 14/211 (6%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT---ALREIKILQLL 73 ++++K+ +G G FG V+K G+KV + + E + P L E ++ + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 + +V L+ IC T + D+ + S L+ + + + Sbjct: 79 DNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ--------I 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ +++HRD+ A NVL+ +K+ DFGLA+ A+ + + +V W Sbjct: 131 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLG-AEEKEYHAEGGKVPIKW 189 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 +L R Y D+W G + E+ T Sbjct: 190 MALESIL--HRIYTHQSDVWSYGVTVWELMT 218 >3LZB-A nrPDB Length = 327 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 90/211 (42%), Gaps = 14/211 (6%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT---ALREIKILQLL 73 ++++K+ +G G FG V+K G+KV + + E + P L E ++ + Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 74 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 + +V L+ IC T + D+ + S L+ + + + Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ--------I 126 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ +++HRD+ A NVL+ +K+ DFGLA+ A+ + + +V W Sbjct: 127 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLG-AEEKEYHAEGGKVPIKW 185 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 +L R Y D+W G + E+ T Sbjct: 186 MALESIL--HRIYTHQSDVWSYGVTVWELMT 214 >6FER-A nrPDB Length = 309 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 60/242 (24%), Positives = 106/242 (43%), Gaps = 43/242 (17%) Query: 24 KIGQGTFGEV----------FK----ARHRKTGQKVALK-KVLMENEKEGFPITALREIK 68 K+G+G FGEV FK A Q V + K+L + + L+EIK Sbjct: 16 KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIK 75 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS---------NVL 118 I+ LK N+++L+ +C T + ++ ++ E+ DL LS + + Sbjct: 76 IMSRLKDPNIIHLLAVCITD--------DPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 119 VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + +K + + +G+ Y+ +HRD+ N L+ ++ +K+ADFG++R Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY--- 184 Query: 179 NSQPNRYTNRVV--TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT---RSPIMQGNT 233 + R R V W +LLG+ + D+W G + E +T P Q + Sbjct: 185 SGDYYRIQGRAVLPIRWMSWESILLGK--FTTASDVWAFGVTLWETFTFCQEQPYSQLSD 242 Query: 234 EQ 235 EQ Sbjct: 243 EQ 244 >4NEU-A nrPDB Length = 333 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/196 (28%), Positives = 91/196 (46%), Gaps = 24/196 (12%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S + + A++ G FG+V HR G + +K V L E K++ L+H Sbjct: 24 SDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHS 82 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIKRVMQML 133 VV L+ + + G LV ++ E G L +VL + LS R++ + Sbjct: 83 RVVKLLGVIIEE--------GKYSLVMEYME---KGNLMHVLKAEMSTPLSVKGRIILEI 131 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA--RAFSLAKNSQPN--RYTNRV 189 + G+ Y+H ++H+D+K N+L+ D +K+AD GLA + +S N + N R + Sbjct: 132 IEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT 191 Query: 190 V-----TLWYRPPELL 200 TL+Y PE L Sbjct: 192 AKKNGGTLYYMAPEHL 207 >4WUA-A nrPDB Length = 401 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 68/290 (23%), Positives = 123/290 (42%), Gaps = 66/290 (22%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH- 75 +Y + K+G G F V+ + + + VA+K V E + TAL EI++L+ +++ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVV---KSAEHYTETALDEIRLLKSVRNS 97 Query: 76 -------ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL-AGLLSNVLVKFTLSEIK 127 E VV L++ K S N I +VF+ H L ++ + L +K Sbjct: 98 DPNDPNREMVVQLLD--DFKISGVNGTH--ICMVFEVLGHHLLKWIIKSNYQGLPLPCVK 153 Query: 128 RVMQMLLNGLYYIH-RNKILHRDMKAANVLIT-----------------RDGVLKLADFG 169 +++Q +L GL Y+H + +I+H D+K N+L++ R G + Sbjct: 154 KIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSA 213 Query: 170 LARAFSLAKNSQPN-------------------------RYTNRVVTLWYRPPELLLGER 204 ++ A + A N N +T + T YR E+L+G Sbjct: 214 VSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGS- 272 Query: 205 DYGPPIDLWGAGCIMAEMWTRSPIMQGNT------EQHQLALISQLCGSI 248 Y P D+W C+ E+ T + + ++ ++ +ALI +L G + Sbjct: 273 GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKV 322 >4NIF-A nrPDB Length = 333 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 68/296 (22%), Positives = 124/296 (41%), Gaps = 55/296 (18%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHENVVNLIE 83 IG G++ E + H+ T + A+K V+ +++++ EI+IL + +H N++ L + Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVK-VIDKSKRD-----PSEEIEILLRYGQHPNIITLKD 69 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGLYYIH 141 + Y+ K +YLV + LL +L + F+ E V+ + + Y+H Sbjct: 70 V-------YDDGK-HVYLVTELMRG--GELLDKILRQKFFSEREASFVLHTIGKTVEYLH 119 Query: 142 RNKILHRDMKAANVLITRDG----VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 ++HRD+K +N+L + L++ DFG A+ ++ T + P Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL----RAENGLLMTPCYTANFVAP 175 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 E +L + Y D+W G ++ M +P G ++ + L G T Sbjct: 176 E-VLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFT------- 227 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 L G V + K DL+ K+L +DP QR+ + L H Sbjct: 228 ----------LSGGNWNTVSETAK---------DLVSKMLHVDPHQRLTAKQVLQH 264 >3UIM-A nrPDB Length = 326 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 101/210 (48%), Gaps = 27/210 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G+G FG+V+K R G VA+K+ L E +G + E++++ + H N++ L Sbjct: 38 LGRGGFGKVYKGR-LADGTLVAVKR-LKEERTQGGELQFQTEVEMISMAVHRNLLRLRGF 95 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI-------KRVMQMLLNGL 137 C T P R LV+ + + G +++ L + S+ +R+ GL Sbjct: 96 CMT---PTERL-----LVYPYMAN---GSVASCLRERPESQPPLDWPKRQRIALGSARGL 144 Query: 138 YYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Y+H + KI+HRD+KAAN+L+ + + DFGLA+ L + T T+ + Sbjct: 145 AYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAK---LMDYKDTHVTTAVRGTIGH 201 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 PE L + D++G G ++ E+ T Sbjct: 202 IAPEYLSTGKS-SEKTDVFGYGVMLLELIT 230 >4HZS-A nrPDB Length = 341 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 88/210 (41%), Gaps = 20/210 (9%) Query: 22 LAKIGQGTFGEVFKAR-HRKTGQKVALKKVLMENEKEGFPITA---LREIKILQLLKHEN 77 L K+G G+FG V + +G+ V++ ++ + P +RE+ + L H N Sbjct: 17 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 76 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLL 134 ++ L + T + +V + L LL + F L + R + Sbjct: 77 LIRLYGVVLTPP---------MKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYAVQVA 125 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+ + +HRD+ A N+L+ ++K+ DFGL RA + + +V W Sbjct: 126 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 185 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 P L R + D W G + EM+T Sbjct: 186 APES--LKTRTFSHASDTWMFGVTLWEMFT 213 >1U54-B nrPDB Length = 291 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 88/210 (41%), Gaps = 20/210 (9%) Query: 22 LAKIGQGTFGEVFKAR-HRKTGQKVALKKVLMENEKEGFPITA---LREIKILQLLKHEN 77 L K+G G+FG V + +G+ V++ ++ + P +RE+ + L H N Sbjct: 23 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 82 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLL 134 ++ L + T + +V + L LL + F L + R + Sbjct: 83 LIRLYGVVLTP---------PMKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYAVQVA 131 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+ + +HRD+ A N+L+ ++K+ DFGL RA + + +V W Sbjct: 132 EGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWC 191 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 P L R + D W G + EM+T Sbjct: 192 APES--LKTRTFSHASDTWMFGVTLWEMFT 219 >5GRN-A nrPDB Length = 356 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/235 (24%), Positives = 104/235 (44%), Gaps = 50/235 (21%) Query: 25 IGQGTFGEVFKA-----RHRKTGQKVA---LKKVLMENEKEGFPITALREIKIL-QLLKH 75 +G G FG+V + + KVA LK +EK+ + E+KI+ L H Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQAL----MSELKIMTHLGPH 109 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLA--------GLLSNVLVKFTLSEI 126 N+VNL+ C TK+ P IY++ ++C + DL LS+ SE+ Sbjct: 110 LNIVNLLGAC-TKSGP-------IYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEV 161 Query: 127 KRVMQ-----------------MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG 169 K ++ + G+ ++ +HRD+ A NVL+ + ++K+ DFG Sbjct: 162 KNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFG 221 Query: 170 LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 LAR + ++ ++ + + W P + + Y D+W G ++ E+++ Sbjct: 222 LARDI-MHDSNYVSKGSTFLPVKWMAPESIF--DNLYTTLSDVWSYGILLWEIFS 273 >3SV0-A nrPDB Length = 483 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 44/154 (28%), Positives = 74/154 (48%), Gaps = 14/154 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG G+FGE++ + +T ++VA+K +EN K P L E KI ++L+ + + Sbjct: 14 KIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHP-QLLYESKIYRILQGGTGIPNVR 69 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 + YN LV D L L + K +L + + ++N + ++H Sbjct: 70 WFGVEGD-YN------VLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSK 122 Query: 144 KILHRDMKAANVLIT---RDGVLKLADFGLARAF 174 LHRD+K N L+ R + + DFGLA+ + Sbjct: 123 SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >4JG6-A nrPDB Length = 355 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 72/315 (22%), Positives = 132/315 (41%), Gaps = 62/315 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHEN 77 YE IG G++ + H+ T + A+K +++ K EI+IL + +H N Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVK--IIDKSKR----DPTEEIEILLRYGQHPN 90 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLN 135 ++ L ++ Y+ K +Y+V + + LL +L + F+ E V+ + Sbjct: 91 IITLKDV-------YDDGK-YVYVVTELMKG--GELLDKILRQKFFSEREASAVLFTITK 140 Query: 136 GLYYIHRNKILHRDMKAANVLITRDG----VLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + Y+H ++HRD+K +N+L + +++ DFG A+ ++ T Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL----RAENGLLMTPCYT 196 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQG--NTEQHQLALISQLCGSI 248 + PE+L + Y D+W G ++ M T +P G +T + LA I S+ Sbjct: 197 ANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 255 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 + W +V + A DL+ K+L +DP QR+ + Sbjct: 256 SGGYWNSVSDT----------------------------AKDLVSKMLHVDPHQRLTAAL 287 Query: 309 ALNHDFF--WSDPMP 321 L H + W D +P Sbjct: 288 VLRHPWIVHW-DQLP 301 >3TKU-A nrPDB Length = 433 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/211 (28%), Positives = 92/211 (43%), Gaps = 19/211 (9%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E + IG+G FGEV + + T +++ K+L + E TA + E Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNT-ERIYAMKILNKWEMLKRAETAC--------FREERD 142 Query: 79 VNLIEICR--TKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 V + C+ T + + +YLV D+ DL LLS K + + ++ Sbjct: 143 VLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 202 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 + IH+ +HRD+K NVL+ +G ++LADFG + Q + V T Y Sbjct: 203 AIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQS---SVAVGTPDYI 259 Query: 196 PPELLLGERD----YGPPIDLWGAGCIMAEM 222 PE+L D YGP D W G M EM Sbjct: 260 SPEILQAMEDGMGKYGPECDWWSLGVCMYEM 290 >4UY9-A nrPDB Length = 323 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 49/222 (22%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALR-EIKILQLLKHENVVNLI 82 IG G FG+V++A G +VA+K + +E I +R E K+ +LKH N++ L Sbjct: 17 IGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 74 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM-QMLLN------ 135 +C + N C LV +F G L+ VL KR+ +L+N Sbjct: 75 GVCLKEP---NLC-----LVMEFAR---GGPLNRVLSG------KRIPPDILVNWAVQIA 117 Query: 136 -GLYYIHRNKI---LHRDMKAANVLITR--------DGVLKLADFGLARAFS-LAKNSQP 182 G+ Y+H I +HRD+K++N+LI + + +LK+ DFGLAR + K S Sbjct: 118 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAA 177 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 Y + PE++ + D+W G ++ E+ T Sbjct: 178 GTYA-------WMAPEVIRASM-FSKGSDVWSYGVLLWELLT 211 >4OTD-A nrPDB Length = 341 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 104/228 (45%), Gaps = 32/228 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKK-----VLMENEKEGFPITALREIKILQLL 73 ++ LA +G+G FG+V + R +G+ A+K ++ +E E + R + + Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESL-MCEKRILAAVTSA 72 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM--Q 131 H +VNL +T P + C E+ G L + SE + + Sbjct: 73 GHPFLVNLFGCFQT---PEHVCF--------VMEYSAGGDLMLHIHSDVFSEPRAIFYSA 121 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 ++ GL ++H +KI++RD+K N+L+ +G +K+ADFGL + + Y +R T Sbjct: 122 CVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK--------EGMGYGDRTST 173 Query: 192 LWYRP----PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 P PE+L + Y +D WG G ++ EM G+ E+ Sbjct: 174 FCGTPEFLAPEVLT-DTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEE 220 >5FM2-A nrPDB Length = 355 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 90/228 (39%), Gaps = 39/228 (17%) Query: 25 IGQGTFGEVFKAR----HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 +G+G FG+V KA + G K+L EN L E +L+ + H +V+ Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIK 131 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV-------------------- 119 L C G + L+ ++ ++ L G L Sbjct: 132 LYGACSQD--------GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHP 183 Query: 120 ---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 T+ ++ + G+ Y+ K++HRD+ A N+L+ +K++DFGL+R Sbjct: 184 DERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-Y 242 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 ++S R R+ W L + Y D+W G ++ E+ T Sbjct: 243 EEDSYVKRSQGRIPVKWMAIESLF--DHIYTTQSDVWSFGVLLWEIVT 288 >5TOS-A nrPDB Length = 395 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/196 (32%), Positives = 88/196 (44%), Gaps = 37/196 (18%) Query: 25 IGQGTFGEVFKA---------RHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLL 73 IG+G FG VFK TG +A+KK+ +EGF L EI L L Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT-----LSEIKR 128 H N+V LI C LV++F + G L N L + L R Sbjct: 129 SHPNLVKLIGYCLEDEHRL--------LVYEFMQK---GSLENHLFRRGAYFKPLPWFLR 177 Query: 129 VMQML--LNGLYYIHRN--KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 V L GL ++H + K+++RD+KA+N+L+ D KL+DFGLAR + S + Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS- 236 Query: 185 YTNRVVTLWYRPPELL 200 T + T Y PE + Sbjct: 237 -TRVMGTYGYAAPEYM 251 >5U6B-A nrPDB Length = 307 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/251 (23%), Positives = 100/251 (39%), Gaps = 40/251 (15%) Query: 25 IGQGTFGEVFKARHRKTGQ--KVALK----KVLMENEKEGFPITALREIKILQLLKHENV 78 +G+G FG V + + + KVA+K + +E E F L E ++ H NV Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDF----LSEAVCMKEFDHPNV 86 Query: 79 VNLIEICRTKASPYNRCKGSIYLVF----DFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 + LI +C + + + L F D L L + V + + M + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 +G+ Y+ + +HRD+ A N ++ + + +ADFGL++ + R V W Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK-WI 205 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 L +R Y D+W G M E+ TR TP +P Sbjct: 206 AIES--LADRVYTSKSDVWSFGVTMWEIATRGQ---------------------TP--YP 240 Query: 255 NVDNYELYEKL 265 V+N E+Y+ L Sbjct: 241 GVENSEIYDYL 251 >3DTC-A nrPDB Length = 271 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 104/221 (47%), Gaps = 47/221 (21%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALR-EIKILQLLKHENVVNLI 82 IG G FG+V++A G +VA+K + +E I +R E K+ +LKH N++ L Sbjct: 15 IGIGGFGKVYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALR 72 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHD-----LAG--LLSNVLVKFTLSEIKRVMQMLLN 135 +C + N C LV +F L+G + ++LV + + +I R Sbjct: 73 GVCLKEP---NLC-----LVMEFARGGPLNRVLSGKRIPPDILVNWAV-QIAR------- 116 Query: 136 GLYYIHRNKI---LHRDMKAANVLITR--------DGVLKLADFGLARAFS-LAKNSQPN 183 G+ Y+H I +HRD+K++N+LI + + +LK+ DFGLAR + K S Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAG 176 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 Y + PE++ + D+W G ++ E+ T Sbjct: 177 AYA-------WMAPEVIRASM-FSKGSDVWSYGVLLWELLT 209 >4AW2-A nrPDB Length = 437 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 91/210 (43%), Gaps = 17/210 (8%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA-LREIKILQLLKHEN 77 +E L IG+G FGEV + K KV K+L + E TA RE + + Sbjct: 76 FEILKVIGRGAFGEVAVVK-LKNADKVFAMKILNKWEMLKRAETACFRE-------ERDV 127 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +VN T + ++YLV D+ DL LLS + + + ++ Sbjct: 128 LVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIA 187 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 + +H+ +HRD+K N+L+ +G ++LADFG Q + V T Y Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQS---SVAVGTPDYIS 244 Query: 197 PELLL----GERDYGPPIDLWGAGCIMAEM 222 PE+L G+ YGP D W G M EM Sbjct: 245 PEILQAMEGGKGRYGPECDWWSLGVCMYEM 274 >4XLV-A nrPDB Length = 328 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 48/182 (26%), Positives = 84/182 (46%), Gaps = 24/182 (13%) Query: 7 SVECPFCDEVS--KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP---- 60 SV P EVS K L ++GQG+FG V++ R + A +V ++ E Sbjct: 27 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRER 86 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV 119 I L E +++ +VV L+ + +K P +V + H DL L ++ Sbjct: 87 IEFLNEASVMKGFTCHHVVRLLGVV-SKGQP-------TLVVMELMAHGDLKSYLRSLRP 138 Query: 120 KF---------TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGL 170 + TL E+ ++ + +G+ Y++ K +HRD+ A N ++ D +K+ DFG+ Sbjct: 139 EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGM 198 Query: 171 AR 172 R Sbjct: 199 TR 200 >3BBT-B nrPDB Length = 328 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 44/167 (26%), Positives = 77/167 (46%), Gaps = 27/167 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALK---KVLMENEKEGFPITALREIKILQLL 73 ++ +++ +G G FG V+K G+ V + K+L E + + E I+ + Sbjct: 15 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASM 74 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV-MQM 132 H ++V L+ +C SP +I LV H L+++ + Q+ Sbjct: 75 DHPHLVRLLGVC---LSP------TIQLVTQLMPH-------GCLLEYVHEHKDNIGSQL 118 Query: 133 LLN-------GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 LLN G+ Y+ +++HRD+ A NVL+ +K+ DFGLAR Sbjct: 119 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLAR 165 >4CRS-A nrPDB Length = 341 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 102/223 (45%), Gaps = 30/223 (13%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKK-----VLMENEKEGFPITALREIKILQLLKHEN 77 A + +G FG+V A ++ T + A+K ++ +E + + R + + ++H Sbjct: 18 AVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSL-MCEKRIFETVNSVRHPF 76 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM--QMLLN 135 +VNL +TK ++ F E+ G L + SE + V ++ Sbjct: 77 LVNLFACFQTKE----------HVCF-VMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVL 125 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL Y+H +KI++RD+K N+L+ +G +K+ADFGL + + Y +R T Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK--------EGMGYGDRTSTFCGT 177 Query: 196 PPEL---LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 P L +L E Y +D WG G ++ EM G+ E+ Sbjct: 178 PEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEE 220 >3PLS-A nrPDB Length = 298 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 95/209 (45%), Gaps = 19/209 (9%) Query: 25 IGQGTFGEVF------KARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 IG+G FG V+ +A++R +L ++ + E F LRE +++ L H NV Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAF----LREGLLMRGLNHPNV 84 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + LI I +G +++ + C DL + + T+ ++ + G+ Sbjct: 85 LALIGIMLPP-------EGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGM 137 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ K +HRD+ A N ++ +K+ADFGLAR + ++ + + + + Sbjct: 138 EYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTAL 197 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 E L R + D+W G ++ E+ TR Sbjct: 198 ESLQTYR-FTTKSDVWSFGVLLWELLTRG 225 >5FQD-C nrPDB Length = 341 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 48/161 (29%), Positives = 81/161 (50%), Gaps = 14/161 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 KY+ + KIG G+FG+++ A + G++VA+K +E++K P L E K+ ++L + Sbjct: 19 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHP-QLLYESKLYKIL--Q 72 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 V + I Y + K LV D L L + +FT+ + + +++ Sbjct: 73 GGVGIPHI-----RWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISR 127 Query: 137 LYYIHRNKILHRDMKAANVL--ITRD-GVLKLADFGLARAF 174 + Y+H +HRD+K N L I R L L DFGLA+ + Sbjct: 128 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >2BUJ-A nrPDB Length = 317 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 100/230 (43%), Gaps = 36/230 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y + K+G+G F V G ALK++L +++ A RE + +L H N+ Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQD--REEAQREADMHRLFNHPNI 88 Query: 79 VNLIEIC-RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF-------TLSEIKRVM 130 + L+ C R + + K +L+ F + G L N + + T +I ++ Sbjct: 89 LRLVAYCLRERGA-----KHEAWLLLPFFKR---GTLWNEIERLKDKGNFLTEDQILWLL 140 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG-LARAFSLAKNSQP----NRY 185 + GL IH HRD+K N+L+ +G L D G + +A + S+ + Sbjct: 141 LGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDW 200 Query: 186 TNRVVTLWYRPPEL-------LLGERDYGPPIDLWGAGCIM-AEMWTRSP 227 + T+ YR PEL ++ ER D+W GC++ A M+ P Sbjct: 201 AAQRCTISYRAPELFSVQSHCVIDER-----TDVWSLGCVLYAMMFGEGP 245 >2RIO-A nrPDB Length = 434 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 68/319 (21%), Positives = 131/319 (41%), Gaps = 68/319 (21%) Query: 25 IGQGTFGEV-FKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHENVVNLI 82 +G G+ G V F+ + G+ VA+K++L++ F AL EIK+L + H NV+ Sbjct: 23 LGYGSSGTVVFQGSFQ--GRPVAVKRMLID-----FCDIALMEIKLLTESDDHPNVIRYY 75 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR------VMQMLLNG 136 C + +Y+ + C +L L+ + V ++++ +++ + +G Sbjct: 76 --CSETTDRF------LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASG 127 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLK-------------LADFGLARAFSLAKNSQPN 183 + ++H KI+HRD+K N+L++ ++DFGL + ++S Sbjct: 128 VAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRT 187 Query: 184 RYTNRVVTLWYRPPEL------LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 N T +R PEL L +R ID++ GC+ + ++ G+ + Sbjct: 188 NLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE 247 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 +I + ++D + L+ A DLI +++ Sbjct: 248 SNIIRGIF---------SLDEMKCLHDRSLIAE-----------------ATDLISQMID 281 Query: 298 LDPAQRIDSDDALNHDFFW 316 DP +R + L H FW Sbjct: 282 HDPLKRPTAMKVLRHPLFW 300 >1KOB-A nrPDB Length = 387 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 71/309 (22%), Positives = 121/309 (39%), Gaps = 59/309 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI---TALREIKILQLLKH 75 Y+ L ++G G FG V + + TG+ K + +P+ T EI I+ L H Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFI-----NTPYPLDKYTVKNEISIMNQLHH 107 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLL 134 ++NL + K + L+ +F +L ++ K + +E+ M+ Sbjct: 108 PKLINLHDAFEDKYE--------MVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQAC 159 Query: 135 NGLYYIHRNKILHRDMKAANVL--ITRDGVLKLADFGLARAFSLAKNSQPNRYTN-RVVT 191 GL ++H + I+H D+K N++ + +K+ DFGLA + P+ T Sbjct: 160 EGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLN------PDEIVKVTTAT 213 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + PE++ E G D+W G + + L+ +S G E Sbjct: 214 AEFAAPEIVDRE-PVGFYTDMWAIGVLGYVL---------------LSGLSPFAGEDDLE 257 Query: 252 VWPNVD--NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 NV ++E E D + P A D I LL +P +R+ DA Sbjct: 258 TLQNVKRCDWEFDE-------------DAFSSV--SPEAKDFIKNLLQKEPRKRLTVHDA 302 Query: 310 LNHDFFWSD 318 L H + D Sbjct: 303 LEHPWLKGD 311 >3QUP-A nrPDB Length = 323 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 98/230 (42%), Gaps = 28/230 (12%) Query: 25 IGQGTFGEVFKARHRK---TGQKVALK----KVLMENEKEGFPITALREIKILQLLKHEN 77 +G+G FG V +A+ ++ + KVA+K ++ ++ E F LRE ++ H + Sbjct: 31 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEF----LREAACMKEFDHPH 86 Query: 78 VVNLIEICRTKASPYNRCKGSI---YLVFDFCEHD------LAGLLSNVLVKFTLSEIKR 128 V L+ + S +R KG + ++ F +H LA + L + R Sbjct: 87 VAKLVGV-----SLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVR 141 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 M + G+ Y+ +HRD+ A N ++ D + +ADFGL+R + + ++ Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKI-YSGDYYRQGCASK 200 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 + W L + Y D+W G M E+ TR E ++ Sbjct: 201 LPVKWLALES--LADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEI 248 >3PP0-A nrPDB Length = 338 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 86/211 (40%), Gaps = 14/211 (6%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALK---KVLMENEKEGFPITALREIKILQLL 73 ++ K+ +G G FG V+K G+ V + KVL EN L E ++ + Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGV 76 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 V L+ IC T + D + L S L+ + + + Sbjct: 77 GSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQ--------I 128 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ +++HRD+ A NVL+ +K+ DFGLAR + ++ + +V W Sbjct: 129 AKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDI-DETEYHADGGKVPIKW 187 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 +L R + D+W G + E+ T Sbjct: 188 MALESIL--RRRFTHQSDVWSYGVTVWELMT 216 >4TN6-A nrPDB Length = 318 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 80/168 (47%), Gaps = 14/168 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 ++Y KIG G+FG+++ G++VA+K +E K P + E KI ++++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHI-ESKIYKMMQGG 62 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 + I C + YN +V + L L + KF+L + + +++ Sbjct: 63 VGIPTIRWCGAEGD-YN------VMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQ 181 + YIH +HRD+K N L+ + ++ + DFGLA+ + A+ Q Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQ 163 >5WNL-A nrPDB Length = 342 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/189 (24%), Positives = 90/189 (47%), Gaps = 20/189 (10%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARH--RKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 + ++ K+G G FG+V+K RH KT + L +++E + L E K +++ Sbjct: 18 DAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMEL--LEEAKKMEM 75 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQ 131 K ++ + Y C+ + LV ++ E L LL++ + + L R++ Sbjct: 76 AKFRYILPV----------YGICQEPVGLVMEYMETGSLEKLLASEPLPWDLR--FRIVH 123 Query: 132 MLLNGLYYIH--RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 G+ ++H +LH ++K AN+L+ +K++DFGLA+ ++ +S Sbjct: 124 ETAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMS-HSHDLSMDGLF 182 Query: 190 VTLWYRPPE 198 T+ Y PPE Sbjct: 183 GTIAYLPPE 191 >6BFN-A nrPDB Length = 342 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/190 (29%), Positives = 89/190 (46%), Gaps = 28/190 (14%) Query: 11 PFC---DEVSK----YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 PFC E+S+ + + KIG+G FG V++A R T V K + E + Sbjct: 9 PFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSF 68 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT- 122 L E++ L +H N+V+ C G LV+ F + G L + L T Sbjct: 69 LTEVEQLSRFRHPNIVDFAGYCAQN--------GFYCLVYGFLPN---GSLEDRLHCQTQ 117 Query: 123 ----LSEIKRVMQML--LNGLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLARAF 174 LS +R+ +L + ++H++ ++H D+K++NVL+ KL DFGLAR F Sbjct: 118 ACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLAR-F 176 Query: 175 SLAKNSQPNR 184 S S P++ Sbjct: 177 SRFAGSSPSQ 186 >3VN9-A nrPDB Length = 340 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 99/219 (45%), Gaps = 38/219 (17%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 E + ++G+G +G V K RH +GQ +A+K++ + + + ++L + Sbjct: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLL--------M 98 Query: 80 NLIEICRTKASPYNRC-------KGSIYLVFDFCEHDLAGLLSNVLVKF-TLSE--IKRV 129 +L RT P+ +G +++ + + L V+ K T+ E + ++ Sbjct: 99 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 158 Query: 130 MQMLLNGLYYIHRN-KILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQPNRYT 186 ++ L ++H ++HRD+K +NVLI G +K+ DFG++ S+AK T Sbjct: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAK-------T 211 Query: 187 NRVVTLWYRPPELL---LGERDYGPPIDLWGAGCIMAEM 222 Y PE + L ++ Y D+W G M E+ Sbjct: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 >3LLT-A nrPDB Length = 360 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 54/334 (16%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 + K+G GTFG V +H + A+K V N K+ + +A E IL+ ++++++ N Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVV--RNIKK-YTRSAKIEADILKKIQNDDINNN 96 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLLNGLYYI 140 + Y + L+F+ L +++ N F + +IK +L L Y+ Sbjct: 97 NIVKYHGKFMY---YDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 141 HRNKILHRDMKAANVLI-------------------------TRDGVLKLADFGLARAFS 175 + + H D+K N+L+ T+ +KL DFG A S Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKS 213 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 S N T YR PE++L + D+W GC++AE++T S + + + Sbjct: 214 DYHGSIIN-------TRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTGSLLFRTHEHM 265 Query: 236 HQLALISQLCGSITPEVW-----PNVDNYELYEKLELVKGQK-------RKVKDRLKAY- 282 LA++ + I + N Y ++L+L + + VK L Y Sbjct: 266 EHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYK 325 Query: 283 -VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 ++ D + +L +DP R + L H F Sbjct: 326 IIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >2VD5-A nrPDB Length = 412 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 98/225 (43%), Gaps = 18/225 (8%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E L IG+G F EV + ++TGQ A+K + + + ++ RE + + + Sbjct: 63 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE-------ERDVL 115 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 VN T+ + + +YLV ++ DL LLS + + + ++ + Sbjct: 116 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 175 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 +HR +HRD+K N+L+ R G ++LADFG + R V T Y P Sbjct: 176 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKL---RADGTVRSLVAVGTPDYLSP 232 Query: 198 ELLLG------ERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQ 235 E+L YGP D W G EM + ++P +T + Sbjct: 233 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAE 277 >2X7G-A nrPDB Length = 389 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 118/292 (40%), Gaps = 72/292 (24%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +Y + K+G G F V+ + + VA+K V + + TAL EIK+L+ ++ Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV---KSAQHYTETALDEIKLLKCVRES 87 Query: 77 N--------VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL-AGLLSNVLVKFTLSEIK 127 + VV LI+ K S N + +VF+ H L ++ + + +K Sbjct: 88 DPSDPNKDMVVQLID--DFKISGMNGIH--VCMVFEVLGHHLLKWIIKSNYQGLPVRCVK 143 Query: 128 RVMQMLLNGLYYIH-RNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQP-- 182 +++ +L GL Y+H + KI+H D+K N+L+ D V ++A A A K P Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMA----AEATEWQKAGAPPP 199 Query: 183 ----------------------------------------NRYTNRVVTLWYRPPELLLG 202 +T + T YR E+L+G Sbjct: 200 SGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIG 259 Query: 203 ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNT------EQHQLALISQLCGSI 248 Y P D+W C+ E+ T + + ++ ++ +A I +L GSI Sbjct: 260 A-GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSI 310 >4EBW-A nrPDB Length = 304 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/205 (22%), Positives = 88/205 (42%), Gaps = 24/205 (11%) Query: 25 IGQGTFGEVFKARH---RKTGQKVALK---KVLMENEKEGFPITALREIKILQLLKHENV 78 IG+G FG+V + + VA+K ++ +E F L+E ++ H ++ Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKF----LQEALTMRQFDHPHI 101 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V LI + + ++++ + C +L L L+ + L L Sbjct: 102 VKLIGVIT---------ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTAL 152 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+ + +HRD+ A NVL++ + +KL DFGL+R + + ++ ++ W P Sbjct: 153 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK--GKLPIKWMAPE 210 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEM 222 + R + D+W G M E+ Sbjct: 211 SINF--RRFTSASDVWMFGVCMWEI 233 >2J0K-A nrPDB Length = 656 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 92/207 (44%), Gaps = 28/207 (13%) Query: 25 IGQGTFGEVFKARH---RKTGQKVALK---KVLMENEKEGFPITALREIKILQLLKHENV 78 IG+G FG+V + + VA+K ++ +E F L+E ++ H ++ Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKF----LQEALTMRQFDHPHI 453 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSEIKRVMQ--MLLN 135 V LI + + ++++ + C L L S + V KF+L ++ L Sbjct: 454 VKLIGVI---------TENPVWIIMELC--TLGELRSFLQVRKFSLDLASLILYAYQLST 502 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L Y+ + +HRD+ A NVL++ +KL DFGL+R + + ++ ++ W Sbjct: 503 ALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASK--GKLPIKWMA 560 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEM 222 P + R + D+W G M E+ Sbjct: 561 PESINF--RRFTSASDVWMFGVCMWEI 585 >4LRM-A nrPDB Length = 334 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 90/214 (42%), Gaps = 17/214 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT---ALREIKILQLL 73 ++++K+ +G G FG V+K G+KV + + E + P L E ++ + Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASV 78 Query: 74 KHE---NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM 130 + +V L+ IC T + D+ + S L+ + + Sbjct: 79 DNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ------ 132 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + G+ Y+ +++HRD+ A NVL+ +K+ DFGLA+ A+ + + +V Sbjct: 133 --IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLG-AEEKEYHAEGGKVP 189 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 W +L R Y D+W G + E+ T Sbjct: 190 IKWMALESIL--HRIYTHQSDVWSYGVTVWELMT 221 >3SXS-A nrPDB Length = 268 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 97/210 (46%), Gaps = 29/210 (13%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L ++G G FG V K K VA+K + + E +E + + L H +V Sbjct: 13 LKELGSGQFG-VVKLGKWKGQYDVAVKMIKEGSMSED---EFFQEAQTMMKLSHPKLVKF 68 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS-EIKRVMQM---LLNGL 137 +C +K P IY+V ++ + G L N L E ++++M + G+ Sbjct: 69 YGVC-SKEYP-------IYIVTEYISN---GCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW---Y 194 ++ ++ +HRD+ A N L+ RD +K++DFG+ R ++Y + V T + + Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV------LDDQYVSSVGTKFPVKW 171 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 PE+ + Y D+W G +M E+++ Sbjct: 172 SAPEVFHYFK-YSSKSDVWAFGILMWEVFS 200 >3HNG-A nrPDB Length = 360 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 51/89 (57%), Gaps = 3/89 (3%) Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++ K +HRD+ A N+L++ + V+K+ DFGLAR + KN R + + L + Sbjct: 211 GMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLAR--DIYKNPDYVRKGDTRLPLKWM 268 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWT 224 PE + ++ Y D+W G ++ E+++ Sbjct: 269 APESIF-DKIYSTKSDVWSYGVLLWEIFS 296 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 71/152 (46%), Gaps = 30/152 (19%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL 64 YD+ + F E K K +G+G FG+V +A + + V ++ KEG + Sbjct: 17 YDASKWEFARERLKLGK--SLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEY 74 Query: 65 R----EIKILQLLKHE-NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 + E+KIL + H NVVNL+ C + P + ++ ++C++ G LSN L Sbjct: 75 KALMTELKILTHIGHHLNVVNLLGACTKQGGP-------LMVIVEYCKY---GNLSNYL- 123 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMK 151 + KR L++++++ LH + K Sbjct: 124 -----KSKR-------DLFFLNKDAALHMEPK 143 >4RT7-A nrPDB Length = 415 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/271 (22%), Positives = 103/271 (38%), Gaps = 74/271 (27%) Query: 25 IGQGTFGEVFKARH---RKTGQKVALK-KVLMENEKEGFPITALREIKIL-QLLKHENVV 79 +G G FG+V A KTG + + K+L E + E+K++ QL HEN+V Sbjct: 73 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 132 Query: 80 NLI-------------EIC---------RTKASPYNRCKGSIYLVFDFCEH--------- 108 NL+ E C R+K ++R I+ +F + Sbjct: 133 NLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNS 192 Query: 109 ---------------DLAGLLSNV--------------------LVKFTLSEIKRVMQML 133 ++GL N L T ++ + Sbjct: 193 SMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQV 252 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ ++ +HRD+ A NVL+T V+K+ DFGLAR ++ ++ R R+ W Sbjct: 253 AKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI-MSDSNYVVRGNARLPVKW 311 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 P L G Y D+W G ++ E+++ Sbjct: 312 MAPESLFEG--IYTIKSDVWSYGILLWEIFS 340 >3I81-A nrPDB Length = 315 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 41/165 (24%), Positives = 80/165 (48%), Gaps = 26/165 (15%) Query: 24 KIGQGTFGEVFKARHRKTGQ-----KVALKKVLMENEKEGFP--ITALREIKILQLLKHE 76 ++GQG+FG V++ + + +VA+K V NE I L E +++ Sbjct: 25 ELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV---NEAASMRERIEFLNEASVMKEFNCH 81 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSN---------VLVKFTLSEIK 127 +VV L+ + ++ P ++ ++ DL L + VL +LS++ Sbjct: 82 HVVRLLGVV-SQGQP------TLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI 134 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 ++ + +G+ Y++ NK +HRD+ A N ++ D +K+ DFG+ R Sbjct: 135 QMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTR 179 >4BTK-A nrPDB Length = 337 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 95/224 (42%), Gaps = 43/224 (19%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +++ L KIG G FGE+++A T + VALK + K+ + E+ +L+ L+ ++ Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM----EVAVLKKLQGKD 112 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGL-LSNVLVKFTLSEIKRVMQMLLNG 136 +CR R + Y+V +LA L S FTLS R+ + +L Sbjct: 113 -----HVCRFIGC--GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILES 165 Query: 137 LYYIHRNKILHRDMKAANVLITR----DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + IH LHRD+K +N + R + DFGLAR +YTN T Sbjct: 166 IEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR-----------QYTN--TTG 212 Query: 193 WYRPPELLLG--------------ERDYGPPIDLWGAGCIMAEM 222 RPP + G R+ G DLW ++ E Sbjct: 213 DVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEF 256 >3QD2-B nrPDB Length = 332 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 9/98 (9%) Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP--------NR 184 + + ++H ++HRD+K +N+ T D V+K+ DFGL A + Q Sbjct: 173 IAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYAT 232 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 +T +V T Y PE + G +Y +D++ G I+ E+ Sbjct: 233 HTGQVGTKLYMSPEQIHG-NNYSHKVDIFSLGLILFEL 269 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 38/64 (59%), Gaps = 1/64 (1%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++ +E + +G+G FG VF+A+++ A+K++ + N +E +RE+K L L+H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEH 63 Query: 76 ENVV 79 +V Sbjct: 64 PGIV 67 >3FME-A nrPDB Length = 290 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 40/220 (18%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 E + ++G+G +G V K RH +GQ +A+K++ + + + ++L + Sbjct: 10 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-------VNSQEQKRLL--------M 54 Query: 80 NLIEICRTKASPYNRC-------KGSIYLVFDFCEHDLAGLLSNVLVKF-TLSE--IKRV 129 +L RT P+ +G +++ + + L V+ K T+ E + ++ Sbjct: 55 DLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKI 114 Query: 130 MQMLLNGLYYIHRN-KILHRDMKAANVLITRDGVLKLADFGLAR------AFSLAKNSQP 182 ++ L ++H ++HRD+K +NVLI G +K+ DFG++ A + +P Sbjct: 115 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKP 174 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 R+ PE L ++ Y D+W G M E+ Sbjct: 175 YMAPERI------NPE--LNQKGYSVKSDIWSLGITMIEL 206 >4F9B-A nrPDB Length = 361 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 93/376 (24%), Positives = 151/376 (40%), Gaps = 89/376 (23%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHR-KTG--QKVALKKVLMENEKE 57 + K Y++V P V K E KIG+GTF V+ A + + G +K+ALK ++ + Sbjct: 9 IEKLYEAV--PQLSNVFKIED--KIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSH-- 62 Query: 58 GFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNV 117 PI E++ L + ++ V ++ C K + + + EH+ ++ Sbjct: 63 --PIRIAAELQCLTVAGGQDNVMGVKYCFRK-------NDHVVIAMPYLEHES---FLDI 110 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSL 176 L + E++ M L L IH+ I+HRD+K +N L R L DFGLA+ Sbjct: 111 LNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHD 170 Query: 177 AK---------NSQPNRYTN---------------RVVTLWYRPPELLLGERDYGPPIDL 212 K +Q R + R T +R PE+L + ID Sbjct: 171 TKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAID- 229 Query: 213 WGAGCIMAEMWT-----------RSPIMQGNTEQHQLALISQLCGS-------------- 247 MW+ R P + + + LA I + GS Sbjct: 230 ---------MWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSI 280 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD--------PYALDLIDKLLVLD 299 + + P D +L E+L + K+ ++ + + A DL+DKLL L+ Sbjct: 281 LCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLN 340 Query: 300 PAQRIDSDDALNHDFF 315 PA RI +++AL H FF Sbjct: 341 PASRITAEEALLHPFF 356 >4YFF-A nrPDB Length = 311 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 93/222 (41%), Gaps = 32/222 (14%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL-REIKILQLL 73 ++S+ E IG G+FG+V+K R R + VA+K+ + RE+ IL L Sbjct: 40 QLSEIEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQL 97 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM- 132 H V+ + C S + I G L ++L E KR++ + Sbjct: 98 NHPCVIQFVGACLNDPSQFAIVTQYIS----------GGSLFSLL-----HEQKRILDLQ 142 Query: 133 --------LLNGLYYIHR--NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 + G+ Y+H I+HRD+ + N+L+ DG +ADFG +R ++ Sbjct: 143 SKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESR---FLQSLDE 199 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + T + L + PE+ Y D++ + E+ T Sbjct: 200 DNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT 241 >4NFN-A nrPDB Length = 309 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 57/192 (29%), Positives = 87/192 (45%), Gaps = 29/192 (15%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +++ L KIG G FGE+++A T + VALK + K+ + E+ +L+ L+ ++ Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM----EVAVLKKLQGKD 77 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGL-LSNVLVKFTLSEIKRVMQMLLNG 136 +CR R + Y+V +LA L S FTLS R+ + +L Sbjct: 78 -----HVCRFIGC--GRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILES 130 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + IH LHRD+K +N + R + DFGLAR +YTN T Sbjct: 131 IEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLAR-----------QYTN--TTG 177 Query: 193 WYRPPELLLGER 204 RPP + G R Sbjct: 178 DVRPPRNVAGFR 189 >2H34-A nrPDB Length = 309 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/225 (27%), Positives = 98/225 (43%), Gaps = 23/225 (10%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI---TALREIKILQLLKHENVVNL 81 +G+G G+V++A + VALK LM P+ RE + L+ +VV + Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALK--LMSETLSSDPVFRTRMQREARTAGRLQEPHVVPI 99 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRV--MQMLLNGLY 138 + + G +Y+ DLA +L + L+ + V ++ + + L Sbjct: 100 HD--------FGEIDGQLYVDMRLINGVDLAAMLRR---QGPLAPPRAVAIVRQIGSALD 148 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 H HRD+K N+L++ D L DFG+A A + K +Q N V TL+Y PE Sbjct: 149 AAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQ---LGNTVGTLYYMAPE 205 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 E D++ C++ E T SP QG+ A I+Q Sbjct: 206 -RFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQ 249 >3AOX-A nrPDB Length = 344 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 92/214 (42%), Gaps = 25/214 (11%) Query: 25 IGQGTFGEVFKAR-----HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 +G G FGEV++ + + + +VA+K L E E + L E I+ H+N+V Sbjct: 55 LGHGAFGEVYEGQVSGMPNDPSPLQVAVK-TLPEVCSEQDELDFLMEALIISKFNHQNIV 113 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRVMQML 133 I + + L+ DL L + + ++ V + + Sbjct: 114 RCIGVSLQSLPRF-------ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDI 166 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQPNRYTNRVV 190 G Y+ N +HRD+ A N L+T G V K+ DFG+AR + + S + ++ Sbjct: 167 ACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMAR--DIYRASYYRKGGCAML 224 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + + PPE + E + D W G ++ E+++ Sbjct: 225 PVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFS 257 >6FEX-A nrPDB Length = 321 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 78/177 (44%), Gaps = 36/177 (20%) Query: 24 KIGQGTFGEV---------------FKARHRKTGQKVALKKVLMENEKEGFPITALREIK 68 K+G+G FGEV F RK + K+L + + L+E+K Sbjct: 23 KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVK 82 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE-- 125 I+ LK N++ L+ +C + P + ++ D+ E+ DL LS ++ +E Sbjct: 83 IMSRLKDPNIIRLLGVC-VQDDP-------LCMITDYMENGDLNQFLSAHQLEDKAAEGA 134 Query: 126 ----------IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 + V + +G+ Y+ +HRD+ N L+ + +K+ADFG++R Sbjct: 135 PGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 191 >3G0E-A nrPDB Length = 336 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 88/223 (39%), Gaps = 34/223 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA----LREIKILQLL-KHENVV 79 +G G FG+V +A + A V ++ K +T + E+K+L L H N+V Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIV 113 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM------ 132 NL+ C G ++ ++C + DL L F S+ + Sbjct: 114 NLLGACTIG--------GPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELAL 165 Query: 133 -----------LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 + G+ ++ +HRD+ A N+L+T + K+ DFGLAR N Sbjct: 166 DLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 225 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + R+ W P + Y D+W G + E+++ Sbjct: 226 V-KGNARLPVKWMAPESIF--NCVYTFESDVWSYGIFLWELFS 265 >3G2F-A nrPDB Length = 336 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 99/225 (44%), Gaps = 32/225 (14%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L IG+G +G V+K + + VA+K N + + I + L++H+N+ Sbjct: 18 LELIGRGRYGAVYKGSLDE--RPVAVKVFSFANRQN---FINEKNIYRVPLMEHDNIARF 72 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVMQMLLNGLYY 139 I + + + R + YL+ E+ G L L T + R+ + GL Y Sbjct: 73 I-VGDERVTADGRME---YLLV--MEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAY 126 Query: 140 IH---------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP----NRYT 186 +H + I HRD+ + NVL+ DG ++DFGL+ + + +P N Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 187 NRVVTLWYRPPELLLGE---RDYGPP---IDLWGAGCIMAEMWTR 225 + V T+ Y PE+L G RD +D++ G I E++ R Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMR 231 >2I0E-A nrPDB Length = 353 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/236 (21%), Positives = 100/236 (42%), Gaps = 25/236 (10%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKI 69 +++ + L +G+G+FG+V + + T + A+K V+ +++ E + E ++ Sbjct: 18 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE----CTMVEKRV 73 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKR 128 L L + + C +Y V ++ DL + V +F Sbjct: 74 LALPGKPPFLTQLHSCFQTMD-------RLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVF 125 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + GL+++ I++RD+K NV++ +G +K+ADFG+ + +N T Sbjct: 126 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKT 180 Query: 189 VV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 T Y PE ++ + YG +D W G ++ EM +G E I + Sbjct: 181 FCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 235 >3VHK-A nrPDB Length = 368 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 50/89 (56%), Gaps = 3/89 (3%) Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++ K +HRD+ A N+L++ V+K+ DFGLAR + K+ R + + L + Sbjct: 212 GMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLAR--DIYKDPDYVRKGDARLPLKWM 269 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWT 224 PE + +R Y D+W G ++ E+++ Sbjct: 270 APETIF-DRVYTIQSDVWSFGVLLWEIFS 297 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 19/105 (18%) Query: 15 EVSKYE------KLAK-IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-- 65 + SK+E KL K +G+G FG+V +A + + V ++ KEG + R Sbjct: 20 DASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRAL 79 Query: 66 --EIKIL-QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE 107 E+KIL + H NVVNL+ C P + ++ +FC+ Sbjct: 80 MSELKILIHIGHHLNVVNLLGACTKPGGP-------LMVIVEFCK 117 >3PFQ-A nrPDB Length = 674 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/227 (22%), Positives = 98/227 (43%), Gaps = 25/227 (11%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKI 69 +++ + L +G+G+FG+V + + T + A+K V+ +++ E + E ++ Sbjct: 339 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE----CTMVEKRV 394 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKR 128 L L + + C +Y V ++ DL + V +F Sbjct: 395 LALPGKPPFLTQLHSCFQTMD-------RLYFVMEYVNGGDLMYHIQQV-GRFKEPHAVF 446 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + GL+++ I++RD+K NV++ +G +K+ADFG+ + +N T Sbjct: 447 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKT 501 Query: 189 VV-TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 T Y PE ++ + YG +D W G ++ EM +G E Sbjct: 502 FCGTPDYIAPE-IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE 547 >3ZZW-A nrPDB Length = 289 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/226 (22%), Positives = 102/226 (45%), Gaps = 37/226 (16%) Query: 22 LAKIGQGTFGEVFKAR-----HRKTGQKVALKKVLMENEKEGFPITALREIKILQL-LKH 75 + ++G+ FG+V+K + Q VA+K ++++ EG R +L+ L+H Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKT--LKDKAEGPLREEFRHEAMLRARLQH 71 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH--------------DLAGLLSNVLVKF 121 NVV L+ + TK P + ++F +C H D+ + VK Sbjct: 72 PNVVCLLGVV-TKDQP-------LSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 123 Query: 122 TLS--EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 L + ++ + G+ Y+ + ++H+D+ NVL+ +K++D GL R A Sbjct: 124 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADY 183 Query: 180 SQPNRYTNRVVTL-WYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 + N ++ + W P ++ G+ + D+W G ++ E+++ Sbjct: 184 YK--LLGNSLLPIRWMAPEAIMYGK--FSIDSDIWSYGVVLWEVFS 225 >6BSD-A nrPDB Length = 876 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 78/183 (42%), Gaps = 42/183 (22%) Query: 24 KIGQGTFGEV---------------FKARHRKTGQKVALKKVLMENEKEGFPITALREIK 68 K+G+G FGEV F RK + K+L + + L+E+K Sbjct: 578 KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVK 637 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE-- 125 I+ LK N++ L+ +C + P + ++ D+ E+ DL LS ++ +E Sbjct: 638 IMSRLKDPNIIRLLGVC-VQDDP-------LCMITDYMENGDLNQFLSAHQLEDKAAEGA 689 Query: 126 ----------------IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG 169 + V + +G+ Y+ +HRD+ N L+ + +K+ADFG Sbjct: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749 Query: 170 LAR 172 ++R Sbjct: 750 MSR 752 >1TKI-A nrPDB Length = 321 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 59/298 (19%), Positives = 115/298 (38%), Gaps = 48/298 (16%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 KY +G+G FG V + + + K V ++ + + +EI IL + +H N Sbjct: 6 KYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ---VLVKKEISILNIARHRN 62 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +++L E + + ++F+F D+ ++ + EI + + Sbjct: 63 ILHLHESFESMEE--------LVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEA 114 Query: 137 LYYIHRNKILHRDMKAANVL--ITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 L ++H + I H D++ N++ R +K+ +FG AR N + L + Sbjct: 115 LQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFR----------LLF 164 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE Y P + +MW+ ++ L+ I+ ++ Sbjct: 165 TAPEY------YAPEVHQHDVVSTATDMWSLGTLVYV-----LLSGINPFLAETNQQIIE 213 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 N+ N E E K + A+D +D+LLV + R+ + +AL H Sbjct: 214 NIMNAEYTFDEEAFKEISIE-------------AMDFVDRLLVKERKSRMTASEALQH 258 >4JRN-A nrPDB Length = 372 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 53/241 (21%), Positives = 91/241 (37%), Gaps = 55/241 (22%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 A +G G F V++A +T +++A+K + E E + +L L + + Sbjct: 74 APLGSGGFATVYEATDVETNEELAVKVFMSEKEP--------TDETMLDLQRESSCYRNF 125 Query: 83 EICRTKASPYNRCKGSI----------------------------YLVFDFCEHDLAGLL 114 + +T C+ + +L+ E D++ ++ Sbjct: 126 SLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVI 185 Query: 115 SNVLVKFTL--SEIKRVMQMLLNG-----LYYIHRNKILHRDMKAANVLITRDGVLKLAD 167 S V ++ SE V++M L+ + + I+H D+K AN L+ +DG L L D Sbjct: 186 SWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGD 245 Query: 168 FGLARAFSLAKNSQPNRYTNRVV-TLWYRPPELLLGERD--YGPPIDLWGAGCIMAEMWT 224 FG R N R + T Y PPE Y P D W G + +W Sbjct: 246 FGTYRI---------NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWC 296 Query: 225 R 225 + Sbjct: 297 K 297 >5E8V-A nrPDB Length = 316 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/218 (22%), Positives = 95/218 (43%), Gaps = 24/218 (11%) Query: 25 IGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 +G+G F EV+KA+ ++ T ++ V + +E ++I LKHEN++ + Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFL- 75 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLLNGLYYIH 141 T +L+ F G L L + +S +++++ L G+ ++H Sbjct: 76 ---TAEERKTELGKQYWLITAF---HAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLH 129 Query: 142 RNK---------ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + I+HRD+K++N+L+ D L DFGL+ + + +V T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 193 WYRPPELL-----LGERDYGPPIDLWGAGCIMAEMWTR 225 Y PE+L L + D++ ++ EM +R Sbjct: 190 RYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >4Y83-A nrPDB Length = 332 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 90/209 (43%), Gaps = 33/209 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 I +G FG+V+ A+ KT +++A K + ++ K +++I +HEN+ L Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPS-------DVEIQACFRHENIAELYGA 133 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS------EIKRVMQMLLNGLY 138 + V F E AG +VL K EI V + +L GL Sbjct: 134 VLWGET-----------VHLFME---AGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLD 179 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 ++H K++H D+K +N++ + L DFGL+ + + + Y PE Sbjct: 180 FLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEI----YMSPE 234 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSP 227 ++L R + D++ G + M T +P Sbjct: 235 VILC-RGHSTKADIYSLGATLIHMQTGTP 262 >5VC6-A nrPDB Length = 289 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 69/152 (45%), Gaps = 13/152 (8%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-K 74 +++ +L KIG G FG VFK R G A+K+ ALRE+ +L + Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQ 69 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSN---VLVKFTLSEIKRVM 130 H +VV + + ++C LA +S ++ F +E+K ++ Sbjct: 70 HSHVVRYFSAWAED--------DHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLL 121 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGV 162 + GL YIH ++H D+K +N+ I+R + Sbjct: 122 LQVGRGLRYIHSMSLVHMDIKPSNIFISRTSI 153 >4X7Q-B nrPDB Length = 312 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 32/220 (14%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP-----ITALREIKILQ 71 ++Y +G+G FG VF A HR T + KV+ N G+ +T E+ +L Sbjct: 31 AEYRLGPLLGKGGFGTVF-AGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 72 LLK----HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAG--LLSNVLVKFTLSE 125 + H V+ L++ T+ LV E L L + K L E Sbjct: 90 KVGAGGGHPGVIRLLDWFETQEG--------FMLVL---ERPLPAQDLFDYITEKGPLGE 138 Query: 126 --IKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQP 182 + ++ + + H ++HRD+K N+LI R G KL DFG + +P Sbjct: 139 GPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALL----HDEP 194 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 YT+ T Y PPE + + + P +W G ++ +M Sbjct: 195 --YTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDM 232 >4LQP-A nrPDB Length = 508 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 45/163 (27%), Positives = 74/163 (45%), Gaps = 21/163 (12%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIK----ILQLLKHENVVN 80 IG+G FGEV + + TG+ A+K +L + E + L +K +L VV+ Sbjct: 110 IGKGAFGEVRLVQKKDTGKIYAMKTLL---KSEMYKKDQLAHVKAERDVLAGSDSPWVVS 166 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGL 137 L + +YL+ +F G L +L++ FT + M + + Sbjct: 167 LYYSFQDAQ--------YLYLIMEFLP---GGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 IH+ +HR +K N+LI G +KL+DFGL+ F +S Sbjct: 216 ETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDS 258 >3M42-A nrPDB Length = 299 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 71/300 (23%), Positives = 114/300 (38%), Gaps = 74/300 (24%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G G+V + +++T +K ALK +L + K A RE+++ H I Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALK-MLQDCPK------ARREVEL-----HWRASQCPHI 73 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLNGLYYI 140 R N G L+ D L S + + FT E +M+ + + Y+ Sbjct: 74 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 133 Query: 141 HRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H I HRD+K N+L T + +LKL DFG A+ + Sbjct: 134 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---------------------- 171 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW--PN 255 GE+ Y D+W G IM + P N H LA+ + I + PN Sbjct: 172 ----GEK-YDKSCDMWSLGVIMYILLCGYPPFYSN---HGLAISPGMKTRIRMGQYEFPN 223 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + E+ E++++ LI LL +P QR+ + +NH + Sbjct: 224 PEWSEVSEEVKM-----------------------LIRNLLKTEPTQRMTITEFMNHPWI 260 >4NT4-A nrPDB Length = 312 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 44/161 (27%), Positives = 73/161 (45%), Gaps = 20/161 (12%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE-----NV 78 KIG G FGE+ ++ + VA+K ME K P L E + +LL + Sbjct: 19 KIGCGNFGELRLGKNLYNNEHVAIK---MEPMKSKAPQLHL-EYRFYKLLGSHADNAPDG 74 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + I T YN +V + L L + KF+L + + + LL+ + Sbjct: 75 IPRIYHLGTCGGRYNA------MVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIE 128 Query: 139 YIHRNKILHRDMKAANVLI-----TRDGVLKLADFGLARAF 174 Y+H +++RD+K N LI R+ ++ + DFGLA+ + Sbjct: 129 YVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 >5X1R-A nrPDB Length = 302 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/243 (20%), Positives = 99/243 (40%), Gaps = 32/243 (13%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVL-------------- 51 +S P +++E IG+G FG V++A + + +A+K+ + Sbjct: 10 NSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIG 69 Query: 52 MENEKEGFPITA-----LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC 106 + E+ G A ++E ++L H +++++ + Y G+ + + Sbjct: 70 LRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAY---MGTQF----YS 122 Query: 107 EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLA 166 L L + K + I+R++ L + + IH+ LHRD+ N+ I + L Sbjct: 123 GTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLL 182 Query: 167 DFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERD--YGPPIDLWGAGCIMAEMWT 224 DFG AR + + T V+ + P E D GP D++ G ++ + Sbjct: 183 DFGSAR----KEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIV 238 Query: 225 RSP 227 SP Sbjct: 239 GSP 241 >3ZBF-A nrPDB Length = 322 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/220 (21%), Positives = 89/220 (40%), Gaps = 34/220 (15%) Query: 25 IGQGTFGEVFKARHRK-----TGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 +G G FGEV++ +G+ K L + + I L+E ++ H N++ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 100 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM------- 132 + +C Y++ + E G L L K ++ + Sbjct: 101 KQLGVCLLNEPQ--------YIILELME---GGDLLTYLRKARMATFYGPLLTLVDLVDL 149 Query: 133 ---LLNGLYYIHRNKILHRDMKAANVLI-----TRDGVLKLADFGLARAFSLAKNSQPNR 184 + G Y+ R +HRD+ A N L+ T ++K+ DFGLAR + KN + Sbjct: 150 CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLAR--DIYKNDYYRK 207 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 ++ + + PE L+ + + D+W G ++ E+ T Sbjct: 208 RGEGLLPVRWMAPESLM-DGIFTTQSDVWSFGILIWEILT 246 >2C47-A nrPDB Length = 313 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 65/156 (41%), Gaps = 16/156 (10%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG G FGE+ ++ T + VA+K +E K P L QL E V + Sbjct: 11 KIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHLEYRFYKQLSATEGVPQVYY 67 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 + C +V + L L FTL + + L+ + Y+H Sbjct: 68 --------FGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTK 119 Query: 144 KILHRDMKAANVLITRDGV-----LKLADFGLARAF 174 +++RD+K N L+ R G + + DFGLA+ + Sbjct: 120 SLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEY 155 >4H1J-A nrPDB Length = 293 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 86/211 (40%), Gaps = 36/211 (17%) Query: 25 IGQGTFGEVFKARH-RKTGQKVAL-----KKVLMENEKEGFPITALREIKILQLLKHENV 78 +G+G FGEV++ + G+K+ + KK + KE F + E I++ L H ++ Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKF----MSEAVIMKNLDHPHI 87 Query: 79 VNLIEICRTKAS-------PYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 V LI I + + PY + + E + L LV ++L Sbjct: 88 VKLIGIIEEEPTWIIMELYPYGE-------LGHYLERNKNSLKVLTLVLYSLQ------- 133 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + + Y+ +HRD+ N+L+ +KL DFGL+R + + R+ Sbjct: 134 -ICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKAS--VTRLPI 190 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 W P + R + D+W M E+ Sbjct: 191 KWMSPESINF--RRFTTASDVWMFAVCMWEI 219 >5WNO-A nrPDB Length = 330 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/222 (22%), Positives = 93/222 (41%), Gaps = 28/222 (12%) Query: 24 KIGQGTFGEVFKA-----RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 K+G G FG VF R + VA+K + + L E + L+H+N+ Sbjct: 29 KLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTD---EMLEEATNMFRLRHDNL 85 Query: 79 VNLIEICR----TKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 + +I C K R G++ + +L G VL + ++ Sbjct: 86 LKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENL-GAREQVLYCYQIA---------- 134 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 +G+ Y+ + +++HRD+ NVL+ + +++ DFGL++ +S + + +V W Sbjct: 135 SGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIK-SGKVAIKWL 193 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT--RSPIMQGNTE 234 + + Y D+W G E+ T +SP +T+ Sbjct: 194 AIE--IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTD 233 >5TUR-A nrPDB Length = 404 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 7/91 (7%) Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L + + H +LHRD+K N+LI + G LKL DFG + +L K++ YT+ T Sbjct: 242 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDTV---YTDFDGT 295 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 Y PPE + R +G +W G ++ +M Sbjct: 296 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 326 >4RC3-A nrPDB Length = 289 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 7/91 (7%) Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L + + H +LHRD+K N+LI + G LKL DFG + +L K++ YT+ T Sbjct: 127 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDTV---YTDFDGT 180 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 Y PPE + R +G +W G ++ +M Sbjct: 181 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 211 >3BGP-A nrPDB Length = 333 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 7/91 (7%) Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L + + H +LHRD+K N+LI + G LKL DFG + +L K++ YT+ T Sbjct: 171 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDTV---YTDFDGT 224 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 Y PPE + R +G +W G ++ +M Sbjct: 225 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 255 >5AR8-A nrPDB Length = 326 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/179 (23%), Positives = 80/179 (44%), Gaps = 49/179 (27%) Query: 19 YEKLAKI---GQGTFGEVFKARHRKTGQKVALKKV-----LMENEKEGFPITALREIKIL 70 Y KLA + +G G V ARH +VA+K + L+++E++ LRE +IL Sbjct: 31 YHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKD----VLREAEIL 86 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--- 127 + ++ ++ IC E + G+++ + +L+E+ Sbjct: 87 HKARFSYILPILGICN--------------------EPEFLGIVTEYMPNGSLNELLHRK 126 Query: 128 ------------RVMQMLLNGLYYIHR--NKILHRDMKAANVLITRDGVLKLADFGLAR 172 R++ + G+ Y+H +LH D+K N+L+ + +K+ADFGL++ Sbjct: 127 TEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >3LMG-A nrPDB Length = 344 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/159 (22%), Positives = 70/159 (44%), Gaps = 13/159 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQK----VALKKVLMENEKEGFPITALREIKILQL 72 ++ KL +G G FG V K G+ V +K + ++ ++ F + I L Sbjct: 31 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSL 90 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 H ++V L+ +C + + + D L +L+ + + Sbjct: 91 -DHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQ-------- 141 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171 + G+YY+ + ++HR++ A NVL+ +++ADFG+A Sbjct: 142 IAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVA 180 >2CMW-A nrPDB Length = 310 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 44/161 (27%), Positives = 69/161 (42%), Gaps = 25/161 (15%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN-----V 78 KIG G FGE+ ++ T + VA+K +E K P L E + + L V Sbjct: 7 KIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLGSAGEGLPQV 62 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + A S+ +FD C+ FTL + + LL+ + Sbjct: 63 YYFGPCGKYNAMVLELLGPSLEDLFDLCDR-----------TFTLKTVLMIAIQLLSRME 111 Query: 139 YIHRNKILHRDMKAANVLITRDG-----VLKLADFGLARAF 174 Y+H +++RD+K N LI R G V+ + DFGLA+ + Sbjct: 112 YVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEY 152 >4F0G-A nrPDB Length = 287 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 50/174 (28%), Positives = 76/174 (43%), Gaps = 25/174 (14%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKK-VLMENEKEGFPITAL----RE 66 D +YEK +IG+G FG V K R K VA+K +L ++E E I RE Sbjct: 16 LADNEIEYEK--QIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQRE 73 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSE 125 + I+ L H N+V L Y +V +F DL L + S Sbjct: 74 VFIMSNLNHPNIVKL----------YGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSV 123 Query: 126 IKRVMQMLLNGLYYIHRNK--ILHRDMKAANVLI-----TRDGVLKLADFGLAR 172 R+M + G+ Y+ I+HRD+++ N+ + K+ADFGL++ Sbjct: 124 KLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ 177 >5X18-A nrPDB Length = 295 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/173 (27%), Positives = 74/173 (42%), Gaps = 26/173 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHEN 77 Y+ KIG+G+FG +F+ + G VA+K E K P LR E K ++L Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIK---FEPRKTEAP--QLRDEYKTYKILN--- 60 Query: 78 VVNLIEICRTKASPYNRCKGS----IYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 T PY G LV D L L KF++ + +V + Sbjct: 61 --------GTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQM 112 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAFSLAKNSQ 181 + + +H + +++RD+K N LI R G + L DFG+A+ + K Q Sbjct: 113 ITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQ 165 >4MWI-A nrPDB Length = 294 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 99/229 (43%), Gaps = 39/229 (17%) Query: 65 REIKILQLLKHENVVNLIEIC--RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 +EIK ++ + N++ + IC T P +V ++CE G L +L + Sbjct: 72 KEIKTMKKFESPNILRIFGICIDETVTPP------QFSIVMEYCE---LGTLRELLDREK 122 Query: 123 LSEIKRVMQMLLN---GLYYIHRNKI--LHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 + + M ++L GLY +H ++ LH ++++N L+T+ +KLA F L + + Sbjct: 123 DLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSM 182 Query: 178 KNSQPNRYTNRV-VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG-NTEQ 235 T+RV T + P EL Y +++ G ++ E+ T QG N+E+ Sbjct: 183 SLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEK 242 Query: 236 -------------------HQLALISQLCGSITPEVWPNVDNYELYEKL 265 +L I C + P V P+VD E+ +KL Sbjct: 243 IRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVD--EILKKL 289 >1CSN-A nrPDB Length = 298 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 70/163 (42%), Gaps = 20/163 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ +IG+G+FG +F+ + Q+VA+K E + P QL Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIK---FEPRRSDAP----------QLRDEYRT 58 Query: 79 VNLIEICRTKASPYNRCKGSIY--LVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 L+ C + Y + ++ LV D L LL KF++ + + +L Sbjct: 59 YKLLAGCTGIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLAR 118 Query: 137 LYYIHRNKILHRDMKAANVLITR-----DGVLKLADFGLARAF 174 + IH +++RD+K N LI R ++ + DFG+ + + Sbjct: 119 VQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 >4XHH-A nrPDB Length = 403 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 14/154 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG G+FG+++ + +G++VA++ +E+ + P E ++ + L + I Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAIR---LESIRSRHPQLDY-ESRVYKYLSGGVGIPFIR 69 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 + YN +V D L L + KF+ + + ++ + YIH Sbjct: 70 WF-GREGEYNA------MVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGR 122 Query: 144 KILHRDMKAANVLIT---RDGVLKLADFGLARAF 174 +HRD+K N L+ R + + DFGL++ + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >4M69-B nrPDB Length = 283 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/165 (22%), Positives = 77/165 (46%), Gaps = 15/165 (9%) Query: 66 EIKILQLLKHENVVNLIEIC--RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--- 120 EIK ++ N++ + IC +T P +V ++CE G L +L + Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPP------EFSIVMEYCE---LGTLRELLDREKD 108 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA-FSLAKN 179 T+S ++ GLY +H ++ LHR++ +++ L+ +KLA F L++ S+++ Sbjct: 109 LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRT 168 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 ++ + T++ P L Y +++ G ++ E+ T Sbjct: 169 AKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT 213 >2CHL-A nrPDB Length = 351 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 22/159 (13%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV--VNL 81 KIG G FGE+ ++ T + VA+K +E K P L QL + + V Sbjct: 37 KIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYY 93 Query: 82 IEIC-RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 C + A S+ +FD C+ F+L + + L++ + Y+ Sbjct: 94 FGPCGKYNAMVLELLGPSLEDLFDLCDR-----------TFSLKTVLMIAIQLISRMEYV 142 Query: 141 HRNKILHRDMKAANVLITRDG-----VLKLADFGLARAF 174 H +++RD+K N LI R G V+ + DF LA+ + Sbjct: 143 HSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 >4BTF-A nrPDB Length = 469 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 37/165 (22%), Positives = 77/165 (46%), Gaps = 15/165 (9%) Query: 66 EIKILQLLKHENVVNLIEIC--RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--- 120 EIK ++ N++ + IC +T P +V ++CE G L +L + Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPP------EFSIVMEYCE---LGTLRELLDREKD 294 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA-FSLAKN 179 T+S ++ GLY +H ++ LHR++ +++ L+ +KLA F L++ S+++ Sbjct: 295 LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRT 354 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 ++ + T++ P L Y +++ G ++ E+ T Sbjct: 355 AKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT 399 >5M07-A nrPDB Length = 276 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 81/197 (41%), Gaps = 41/197 (20%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV--LMENEKEGFPITALREIKILQLLK 74 + Y + +G GEV+ +H ALK + M + E F RE ++ L Sbjct: 30 AGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDE-FRRRFQRETEVAARLF 88 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-----HDLAGLLSNVLVKFTLSEIKRV 129 H +++ + + G +++ D+ + +A VL + E+ + Sbjct: 89 HPHILEVHD--------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVL---PVGEVLAI 137 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR----DGVLKLADFGLARAFSLAKNSQPNRY 185 + + L Y H+ +LHRD+ ANV++T D + LADFG+A SQP+ Sbjct: 138 VTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA--------SQPS-- 187 Query: 186 TNRVVTLWYRPPELLLG 202 Y PEL G Sbjct: 188 --------YPAPELSAG 196 >5L2Q-C nrPDB Length = 320 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 97/231 (41%), Gaps = 51/231 (22%) Query: 94 RCKGSIYLVFD-FCEHDLAGLLSNV--LVKFTLSEIKRVMQMLLNGLYY--------IHR 142 + K I LV D C HD + +++ L + + E KR+ + ++Y +H+ Sbjct: 113 KMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKE-KRLSERETVVIFYDVVRVVEALHQ 171 Query: 143 NKILHRDMKAAN-VLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 I+HRD+K N VL R + + +F L + S+ + ++ + Y P++L Sbjct: 172 KNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLV----SEGDLLKDQRGSPAYISPDVLS 227 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNY-- 259 G G P D+W G ++ M L Q +P D+ Sbjct: 228 GRPYRGKPSDMWALGVVLFTM-----------------LYGQ---------FPFYDSIPQ 261 Query: 260 ELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 EL+ K +K + + + + + LI KLLVLDP QR+ + D L Sbjct: 262 ELFRK---IKAAEYTIPEDGRV---SENTVCLIRKLLVLDPQQRLAAADVL 306 >4IX6-A nrPDB Length = 350 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 50/120 (41%), Gaps = 21/120 (17%) Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR--DGVLKLADFGLARAFSLAKNS 180 L K+ M+ LL L +H ++HRD+K AN++ GVLKL D G A A L Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA-ALCLPLPE 200 Query: 181 QPNRYTN---------RVVTLWYRPPELLLGERDYGPPI---------DLWGAGCIMAEM 222 N Y + L+ PP +D + D W AGC+M ++ Sbjct: 201 TLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL 260 >4XHL-A nrPDB Length = 394 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 35/154 (22%), Positives = 69/154 (44%), Gaps = 14/154 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG G+FG+++ + +G++VA++ +E+ + P E ++ + L + I Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAIR---LESIRSRHPQLDY-ESRVYRYLSGGVGIPFIR 69 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 + YN +V D L L + +F+ + + + + YIH Sbjct: 70 WF-GREGEYNA------MVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGR 122 Query: 144 KILHRDMKAANVLIT---RDGVLKLADFGLARAF 174 +HRD+K N L+ R + + DFGL++ + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >5UU1-A nrPDB Length = 324 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/171 (26%), Positives = 78/171 (45%), Gaps = 17/171 (9%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV---- 79 KIG G FG ++ A +K A V +E ++ G P+ E+K Q + ++ + Sbjct: 23 KIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENG-PL--FSELKFYQRVAKKDCIKKWI 79 Query: 80 -----NLIEICRTKASPYNRCKGSIY--LVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 + + I S KG Y +V + DL + S F S + ++ Sbjct: 80 ERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI-SGQNGTFKKSTVLQLGIR 138 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQ 181 +L+ L YIH N+ +H D+KAAN+L+ + LAD+GL+ + N + Sbjct: 139 MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 >5VDK-A nrPDB Length = 297 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 70/156 (44%), Gaps = 27/156 (17%) Query: 16 VSKYEK----LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 S+YEK + KIG G FG V+K R G A+K+ + + +AL E+ Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHA 69 Query: 72 LLKHE-NVVNLIEICRTKASPYNRCKGSIYLVF--DFCEHDLAGLLSNVLVKFTLS---- 124 +L H +VV Y+ +++ ++C G L + + T S Sbjct: 70 VLGHHPHVVRY----------YSSWAEDDHMIIQNEYCN---GGSLQAAISENTKSGNHF 116 Query: 125 ---EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI 157 ++K ++ + GL YIH + ++H D+K +N+ I Sbjct: 117 EEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >4L68-A nrPDB Length = 340 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 25/169 (14%) Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLS 124 E+ L L+H N+ L+ C + + LV+ + + L LL + + S Sbjct: 85 EMNQLWELRHSNLAPLLGFCVVEEEKF--------LVYKYMSNGTLHSLLDSNRGELDWS 136 Query: 125 EIKRVMQMLLNGLYYIH---RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 R+ GL ++H R ILH+++ ++ +LI D ++ D GLAR + N++ Sbjct: 137 TRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNE 196 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPI------DLWGAGCIMAEMWT 224 + T + Y PE Y + D++G G ++ E+ T Sbjct: 197 SSFMTGDLGEFGYVAPE-------YSTTMLASLKGDVYGLGVVLLELAT 238 >5J0A-A nrPDB Length = 300 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 14/115 (12%) Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVK-- 120 + E KIL+ L H N+V GS+ L ++ E L L+ Sbjct: 62 MDEAKILKSLHHPNIVGYRAFTEAN-------DGSLCLAMEYGGEKSLNDLIEERYKASQ 114 Query: 121 --FTLSEIKRVMQMLLNGLYYIHRNK-ILHRDMKAANVLITRD-GVLKLADFGLA 171 F + I +V + GL Y+H+ K +LH D+K++NV+I D +K+ D G++ Sbjct: 115 DPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVS 169 >5USZ-A nrPDB Length = 289 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 44/215 (20%), Positives = 86/215 (40%), Gaps = 36/215 (16%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKV-----LMENEKEGFPITALREIKILQLLKHENVV 79 +GQGTF ++FK R+ G L + +++ + + ++ L H+++V Sbjct: 16 LGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLV 75 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLN 135 +C C LV +F + G L L K + V + L Sbjct: 76 LNYGVC--------VCGDENILVQEFVKF---GSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 136 GLYYIHRNKILHRDMKAANVLITRD--------GVLKLADFGLARAFSLAKNSQPNRYTN 187 ++++ N ++H ++ A N+L+ R+ +KL+D G++ L K+ R Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV-LPKDILQERIP- 182 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 + PPE + ++ D W G + E+ Sbjct: 183 ------WVPPECIENPKNLNLATDKWSFGTTLWEI 211 >6J6I-B nrPDB Length = 351 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 42/193 (21%), Positives = 76/193 (39%), Gaps = 44/193 (22%) Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK-----RV 129 H N + L+ C P LVF+F EH V+V S + ++ Sbjct: 117 HSNFLQLLGCCLEFPFPV--------LVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKI 168 Query: 130 MQMLLNGLYYIHR---NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + + N + Y+H I+HRD+K +V + ++ KL+D + + K Sbjct: 169 GKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGK-------- 220 Query: 187 NRVVTLWYRPPELLLGERDYGPPI-----------DLWGAGCIMAEMWTRSPIMQGNTE- 234 +R+ W +LG Y P+ D++ G + + T P + ++ Sbjct: 221 SRIEAEW------VLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDG 274 Query: 235 --QHQLALISQLC 245 Q L+L+ +LC Sbjct: 275 DLQGILSLVRELC 287 >2RSV-A nrPDB Length = 403 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 41/77 (53%), Gaps = 2/77 (2%) Query: 100 YLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 +++ D DL + +F+ + ++ +L+ L YIH ++ +H D+KA+N+L+ Sbjct: 135 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 160 DG--VLKLADFGLARAF 174 + L D+GLA + Sbjct: 195 KNPDQVYLVDYGLAYRY 211 >2PZI-A nrPDB Length = 681 Score = 36.2 bits (82), Expect = 0.024, Method: Compositional matrix adjust. Identities = 50/241 (20%), Positives = 92/241 (38%), Gaps = 40/241 (16%) Query: 10 CPFCDE--------------VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE 55 CP+C +YE I G G ++ A R + + K L+ + Sbjct: 59 CPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSG 118 Query: 56 KEGFPITALREIKILQLLKHENVV---NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAG 112 A+ E + L + H ++V N +E P Y+V ++ Sbjct: 119 DAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVG------YIVMEYVGGQ--S 170 Query: 113 LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 L + K ++E + +L L Y+H +++ D+K N+++T + LKL D G Sbjct: 171 LKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAV- 228 Query: 173 AFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPI--DLWGAGCIMAEMWTRSPIMQ 230 S+ N + T ++ PE++ GP + D++ G +A + P Sbjct: 229 -------SRINSFGYLYGTPGFQAPEIV----RTGPTVATDIYTVGRTLAALTLDLPTRN 277 Query: 231 G 231 G Sbjct: 278 G 278 >4Y12-A nrPDB Length = 375 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 50/241 (20%), Positives = 92/241 (38%), Gaps = 40/241 (16%) Query: 10 CPFCDE--------------VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE 55 CP+C +YE I G G ++ A R + + K L+ + Sbjct: 98 CPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSG 157 Query: 56 KEGFPITALREIKILQLLKHENVV---NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAG 112 A+ E + L + H ++V N +E P Y+V ++ Sbjct: 158 DAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVG------YIVMEYVGGQ--S 209 Query: 113 LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 L + K ++E + +L L Y+H +++ D+K N+++T + LKL D G Sbjct: 210 LKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAV- 267 Query: 173 AFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPI--DLWGAGCIMAEMWTRSPIMQ 230 S+ N + T ++ PE++ GP + D++ G +A + P Sbjct: 268 -------SRINSFGYLYGTPGFQAPEIV----RTGPTVATDIYTVGRTLAALTLDLPTRN 316 Query: 231 G 231 G Sbjct: 317 G 317 >4BWP-A nrPDB Length = 448 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 13/78 (16%) Query: 31 GEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL---LKHENVVNLIEICRT 87 ++A H TG K L+++ GF + + + + ++++ L+H NVV L E+ T Sbjct: 64 ATTYRATHNTTGYKYCLRRI------HGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTT 117 Query: 88 KASPYNRCKGSIYLVFDF 105 KA N S+ LV+D+ Sbjct: 118 KAFGDN----SLVLVYDY 131 >2LAV-A nrPDB Length = 361 Score = 35.4 bits (80), Expect = 0.038, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 41/77 (53%), Gaps = 2/77 (2%) Query: 100 YLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 +++ D DL + +F+ + ++ +L+ L YIH ++ +H D+KA+N+L+ Sbjct: 128 FMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 160 DG--VLKLADFGLARAF 174 + L D+GLA + Sbjct: 188 KNPDQVYLVDYGLAYRY 204 >4WOV-A nrPDB Length = 317 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 14/101 (13%) Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-------LKLADFGLARAFSLAKNSQ 181 V Q L + L Y+ ++H ++ N+L+ R G+ +KL+D G+ +L++ + Sbjct: 162 VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLG-ALSREER 220 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 R W P L G +D WG G + E+ Sbjct: 221 VERIP------WLAPECLPGGANSLSTAMDKWGFGATLLEI 255 >4WWA-A nrPDB Length = 261 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 21/72 (29%), Positives = 35/72 (48%), Gaps = 10/72 (13%) Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL---KLADFGLARAF 174 LV TL ++ R + +L H N H D+ ++N+++ RDG L DFGL Sbjct: 137 LVATTLRKVGRQIGLL-------HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGSVS 189 Query: 175 SLAKNSQPNRYT 186 +L ++ + Y Sbjct: 190 NLVEDKGVDLYV 201 >5C01-A nrPDB Length = 342 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 14/101 (13%) Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-------LKLADFGLARAFSLAKNSQ 181 V Q L + L Y+ ++H ++ N+L+ R G+ +KL+D G+ +L++ + Sbjct: 185 VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLG-ALSREER 243 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 R W P L G +D WG G + E+ Sbjct: 244 VERIP------WLAPECLPGGANSLSTAMDKWGFGATLLEI 278 >3JS9-A nrPDB Length = 156 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 13/42 (30%), Positives = 20/42 (47%) Query: 166 ADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYG 207 DFG+ + F++ S R LW+ P +L+ ER G Sbjct: 111 GDFGVVKNFNIVHASSSAEDAARECALWFTPEQLVTWERSVG 152 >2BEF-A nrPDB Length = 155 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 6/83 (7%) Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 LV F S V+ M+ G + +++ + N L + G ++ DFG+ ++ Sbjct: 68 LVSFITS--GPVVAMVFEGKGVVASARLM---IGVTNPLASAPGSIR-GDFGVDVGRNII 121 Query: 178 KNSQPNRYTNRVVTLWYRPPELL 200 S NR + LW++P ELL Sbjct: 122 HGSDSVESANREIALWFKPEELL 144 >5CLR-A nrPDB Length = 451 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 7/75 (9%) Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 E+ +M + + + H ++HRD+K N+++ D L DFG + S K +P Sbjct: 177 EVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG---SSSSDKEPKPAS 233 Query: 185 YTNRVVTLWYRPPEL 199 + T Y PEL Sbjct: 234 WG----TASYLAPEL 244 >3ENH-A nrPDB Length = 540 Score = 30.8 bits (68), Expect = 0.94, Method: Compositional matrix adjust. Identities = 12/40 (30%), Positives = 25/40 (62%), Gaps = 2/40 (5%) Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 +H+N ++H D+ +N + +D L + DFGL + +L ++ Sbjct: 447 LHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDED 484 >6G38-A nrPDB Length = 357 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 4/46 (8%) Query: 11 PF--CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN 54 PF C K ++ KIG+G FGEVF+ T VA+K + +E Sbjct: 33 PFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEG 76 >4O1O-A nrPDB Length = 717 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 18/74 (24%), Positives = 34/74 (45%), Gaps = 4/74 (5%) Query: 99 IYLVFDFCEHDLAGLLSNVLVKFTLSE----IKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 +++ CE+ L L+N +E + ++ L + +HR+ H+D++ N Sbjct: 413 LHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQN 472 Query: 155 VLITRDGVLKLADF 168 +LI LADF Sbjct: 473 ILIDSKNGTFLADF 486 >3RFI-A nrPDB Length = 108 Score = 27.7 bits (60), Expect = 8.4, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 19/33 (57%) Query: 216 GCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 C MA +W ++ + Q T++ L ++QLC I Sbjct: 75 ACEMAVVWMQNQLKQEGTKEKVLEYVNQLCEKI 107 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3MIA-A nrPDB 480 e-136 5EFQ-A nrPDB 355 2e-98 4NST-A nrPDB 353 1e-97 2BPM-A nrPDB 330 4e-91 3NIZ-A nrPDB 327 5e-90 6GU6-A nrPDB 320 8e-88 4AU8-A nrPDB 315 2e-86 4IC8-A nrPDB 314 4e-86 4QTB-A nrPDB 313 6e-86 5NGU-A nrPDB 311 2e-85 1V0B-A nrPDB 311 3e-85 4KRC-A nrPDB 311 3e-85 5Z33-A nrPDB 308 2e-84 4ZSG-A nrPDB 307 5e-84 4AGU-A nrPDB 307 6e-84 4BBM-A nrPDB 306 9e-84 4EWQ-A nrPDB 306 1e-83 1UA2-A nrPDB 304 5e-83 1CM8-A nrPDB 303 7e-83 3OHT-A nrPDB 303 1e-82 2F9G-A nrPDB 301 4e-82 6DTL-A nrPDB 297 6e-81 4MYG-A nrPDB 295 2e-80 3GC9-A nrPDB 294 4e-80 5G6V-A nrPDB 293 8e-80 3ZDU-A nrPDB 292 2e-79 4BGQ-A nrPDB 291 2e-79 3OZ6-A nrPDB 291 5e-79 1G3N-A nrPDB 289 1e-78 3NCG-A nrPDB 288 2e-78 3GC0-A nrPDB 286 8e-78 4O2Z-A nrPDB 286 8e-78 4QNY-A nrPDB 286 1e-77 2W96-B nrPDB 286 1e-77 1JNK-A nrPDB 283 8e-77 5AWM-A nrPDB 281 4e-76 3E7O-A nrPDB 279 1e-75 2XS0-A nrPDB 276 8e-75 3FI2-A nrPDB 276 1e-74 3PG1-A nrPDB 276 1e-74 5JN2-A nrPDB 276 2e-74 3DFA-A nrPDB 273 1e-73 3RP9-A nrPDB 272 2e-73 3LIJ-A nrPDB 269 1e-72 3HZT-A nrPDB 269 2e-72 3MA6-A nrPDB 267 5e-72 5WAX-A nrPDB 267 6e-72 3DXN-A nrPDB 267 7e-72 5AIR-A nrPDB 266 8e-72 3N9X-A nrPDB 266 1e-71 4MVF-A nrPDB 266 1e-71 2VN9-A nrPDB 265 3e-71 3UC3-A nrPDB 265 3e-71 4E7W-A nrPDB 264 5e-71 4YZB-A nrPDB 263 9e-71 3E3P-A nrPDB 262 2e-70 5U6Y-A nrPDB 261 3e-70 3NIE-A nrPDB 261 4e-70 2VZ6-A nrPDB 260 7e-70 5FG8-A nrPDB 259 2e-69 3MN3-A nrPDB 259 2e-69 2I6L-A nrPDB 258 2e-69 2V7O-A nrPDB 258 3e-69 3ZUT-A nrPDB 257 5e-69 2BDW-A nrPDB 256 1e-68 5Y86-A nrPDB 256 2e-68 3SOA-A nrPDB 256 2e-68 3BHH-A nrPDB 255 2e-68 5ES1-A nrPDB 255 3e-68 3KK8-A nrPDB 253 7e-68 2QNJ-A nrPDB 253 8e-68 4RGJ-A nrPDB 253 1e-67 5YKS-A nrPDB 252 2e-67 3UDB-A nrPDB 252 2e-67 5ZTN-A nrPDB 251 3e-67 5IG1-A nrPDB 251 5e-67 3EB0-A nrPDB 250 7e-67 5KCV-A nrPDB 249 2e-66 5KZ7-A nrPDB 248 3e-66 3Q5I-A nrPDB 247 4e-66 2YCR-A nrPDB 247 5e-66 3MV5-A nrPDB 247 7e-66 3H4J-B nrPDB 247 8e-66 6FD3-A nrPDB 246 2e-65 4REW-A nrPDB 246 2e-65 4FG9-A nrPDB 245 2e-65 3COM-A nrPDB 244 4e-65 2JC6-A nrPDB 243 8e-65 4RED-A nrPDB 242 1e-64 3UTO-A nrPDB 242 1e-64 2JDO-A nrPDB 242 2e-64 3I6U-A nrPDB 242 3e-64 4CFF-A nrPDB 241 3e-64 4CFH-A nrPDB 241 5e-64 2UV2-A nrPDB 241 5e-64 5EZV-A nrPDB 240 7e-64 3DAK-A nrPDB 240 7e-64 1KOA-A nrPDB 240 9e-64 1U5R-A nrPDB 238 3e-63 3TAC-A nrPDB 238 4e-63 3D2K-A nrPDB 237 5e-63 4UZD-A nrPDB 237 5e-63 4CZT-A nrPDB 237 5e-63 2Y7J-A nrPDB 237 5e-63 4B6L-A nrPDB 237 7e-63 5D7A-A nrPDB 237 7e-63 4CQG-A nrPDB 237 8e-63 4JXF-A nrPDB 237 8e-63 2YZA-A nrPDB 236 9e-63 1PHK-A nrPDB 236 1e-62 5KKR-C nrPDB 236 1e-62 4CRL-A nrPDB 236 1e-62 5DBX-A nrPDB 236 2e-62 6O6Q-A nrPDB 236 2e-62 4LG4-A nrPDB 236 2e-62 2J90-A nrPDB 235 2e-62 3F3Z-A nrPDB 235 2e-62 4FIE-A nrPDB 235 2e-62 4D2V-A nrPDB 235 2e-62 2GCD-A nrPDB 235 3e-62 4JDH-A nrPDB 234 4e-62 2JAM-A nrPDB 234 5e-62 2Q0N-A nrPDB 234 5e-62 4XBR-A nrPDB 234 6e-62 3EQC-A nrPDB 234 6e-62 2HAK-A nrPDB 234 6e-62 6C9D-A nrPDB 234 7e-62 4KS7-A nrPDB 233 8e-62 3GUB-A nrPDB 233 9e-62 5XZW-A nrPDB 233 1e-61 3Q53-A nrPDB 233 1e-61 5D9K-A nrPDB 233 1e-61 4I6B-A nrPDB 233 1e-61 6AO5-A nrPDB 232 1e-61 4D28-A nrPDB 232 1e-61 4NIF-A nrPDB 232 1e-61 2PVN-A nrPDB 230 6e-61 4JG6-A nrPDB 229 1e-60 2F57-A nrPDB 229 1e-60 3DB8-A nrPDB 229 1e-60 6HMD-A nrPDB 229 2e-60 6HXF-B nrPDB 228 3e-60 4L42-A nrPDB 228 3e-60 2YAB-A nrPDB 228 3e-60 2W4O-A nrPDB 227 5e-60 2OU7-A nrPDB 227 5e-60 2HW6-A nrPDB 227 6e-60 5J5T-A nrPDB 226 9e-60 5X8I-B nrPDB 226 1e-59 4J52-A nrPDB 226 1e-59 4MD7-E nrPDB 225 2e-59 4U41-A nrPDB 225 3e-59 4PDS-A nrPDB 225 3e-59 6FDY-U nrPDB 225 3e-59 3IS5-A nrPDB 224 4e-59 5JZN-A nrPDB 224 5e-59 6CKI-A nrPDB 224 5e-59 2A27-A nrPDB 223 8e-59 2WO6-A nrPDB 223 1e-58 1FOT-A nrPDB 223 1e-58 5XVU-A nrPDB 222 2e-58 1ZWS-A nrPDB 222 2e-58 5LOH-A nrPDB 222 2e-58 1KOB-A nrPDB 222 2e-58 4RLP-A nrPDB 222 2e-58 2Z7Q-A nrPDB 222 3e-58 6FYV-A nrPDB 221 3e-58 5F9E-A nrPDB 221 3e-58 4AN9-A nrPDB 221 3e-58 4QMW-A nrPDB 221 3e-58 3HKO-A nrPDB 221 4e-58 6EII-A nrPDB 220 8e-58 2X4F-A nrPDB 219 1e-57 2XIK-A nrPDB 219 2e-57 6CMJ-A nrPDB 219 2e-57 6ED6-A nrPDB 219 2e-57 3TXO-A nrPDB 218 3e-57 4FZF-B nrPDB 218 3e-57 6E9W-A nrPDB 218 4e-57 1VZO-A nrPDB 218 4e-57 3HDN-A nrPDB 217 8e-57 4CSV-A nrPDB 216 9e-57 1S9I-A nrPDB 216 9e-57 4YNZ-A nrPDB 215 2e-56 3ORZ-A nrPDB 215 3e-56 5X3F-B nrPDB 214 5e-56 6CQF-A nrPDB 214 6e-56 3RAW-A nrPDB 214 6e-56 4WB7-A nrPDB 213 8e-56 5N23-A nrPDB 213 9e-56 4WNO-A nrPDB 213 1e-55 5YV8-A nrPDB 212 2e-55 4C0T-A nrPDB 211 3e-55 6QAU-A nrPDB 211 4e-55 4APC-A nrPDB 211 4e-55 5DYK-A nrPDB 211 4e-55 4B8L-A nrPDB 210 6e-55 4RA4-A nrPDB 210 1e-54 5UNP-A nrPDB 209 1e-54 3LM0-A nrPDB 209 1e-54 4AF3-A nrPDB 208 3e-54 2WTK-C nrPDB 208 3e-54 5FET-A nrPDB 208 3e-54 3NYO-A nrPDB 205 2e-53 2BRG-A nrPDB 205 2e-53 4LFI-A nrPDB 205 2e-53 1ZXE-A nrPDB 205 2e-53 3A8W-A nrPDB 205 2e-53 3KN6-A nrPDB 205 3e-53 4IAN-A nrPDB 205 3e-53 3FXW-A nrPDB 204 5e-53 3PPZ-A nrPDB 204 6e-53 3TKU-A nrPDB 204 8e-53 2H8H-A nrPDB 203 9e-53 2WQN-A nrPDB 203 1e-52 5MJB-A nrPDB 202 2e-52 4AW2-A nrPDB 202 2e-52 6F3F-A nrPDB 201 4e-52 4P5Q-A nrPDB 200 5e-52 1NY3-A nrPDB 200 6e-52 3KA0-A nrPDB 200 7e-52 3PFQ-A nrPDB 200 7e-52 6BXI-A nrPDB 200 7e-52 6E2O-A nrPDB 200 8e-52 2OZA-A nrPDB 200 9e-52 2R2P-A nrPDB 199 1e-51 4XEY-B nrPDB 199 1e-51 6BDL-A nrPDB 199 2e-51 2VWV-A nrPDB 199 2e-51 4OLI-A nrPDB 198 3e-51 5L6P-A nrPDB 198 3e-51 2Y6O-A nrPDB 198 3e-51 5O2B-A nrPDB 198 3e-51 2FO0-A nrPDB 198 3e-51 2I0E-A nrPDB 198 4e-51 5SYS-A nrPDB 198 4e-51 2DQ7-X nrPDB 197 4e-51 3VN9-A nrPDB 197 5e-51 5O2C-A nrPDB 197 5e-51 3DKO-A nrPDB 197 6e-51 6DBM-A nrPDB 197 7e-51 2WTK-B nrPDB 197 8e-51 1JPA-A nrPDB 197 9e-51 2X7G-A nrPDB 196 1e-50 4TNB-A nrPDB 196 1e-50 3OMV-A nrPDB 196 2e-50 2VD5-A nrPDB 196 2e-50 4E93-A nrPDB 196 2e-50 4GS6-A nrPDB 195 2e-50 2XNP-A nrPDB 195 3e-50 3FME-A nrPDB 195 3e-50 6NPU-A nrPDB 195 3e-50 4FR4-A nrPDB 195 3e-50 4E20-A nrPDB 194 4e-50 3KUL-B nrPDB 194 4e-50 6DBN-A nrPDB 194 5e-50 4PDO-A nrPDB 194 5e-50 3ORP-A nrPDB 194 5e-50 2XYN-A nrPDB 194 6e-50 3ALO-A nrPDB 194 7e-50 3C51-A nrPDB 194 7e-50 5H2U-A nrPDB 193 9e-50 4PWN-A nrPDB 193 1e-49 4AT3-A nrPDB 193 1e-49 4EQM-A nrPDB 192 2e-49 4M7I-A nrPDB 192 2e-49 4WUA-A nrPDB 192 2e-49 4XUF-A nrPDB 191 3e-49 4EBW-A nrPDB 191 4e-49 3V5Q-A nrPDB 191 4e-49 2JD5-A nrPDB 191 4e-49 5X02-A nrPDB 191 5e-49 3A4O-X nrPDB 190 8e-49 5A46-A nrPDB 189 1e-48 3TT0-A nrPDB 189 1e-48 1LUF-A nrPDB 189 2e-48 3QGY-A nrPDB 189 2e-48 6CCF-A nrPDB 189 2e-48 3IO7-A nrPDB 189 2e-48 4HVI-A nrPDB 189 2e-48 3GQL-A nrPDB 189 2e-48 1TKI-A nrPDB 189 3e-48 5UUU-A nrPDB 188 3e-48 5HIE-A nrPDB 188 3e-48 2J0K-A nrPDB 188 3e-48 5VO2-A nrPDB 188 3e-48 2W1I-A nrPDB 188 4e-48 3PVW-A nrPDB 188 4e-48 5KMM-A nrPDB 187 5e-48 4XCU-A nrPDB 187 5e-48 5HI2-A nrPDB 187 6e-48 3QA8-A nrPDB 187 6e-48 2PSQ-A nrPDB 187 7e-48 2PL0-A nrPDB 187 9e-48 4KIK-B nrPDB 186 1e-47 4XI2-A nrPDB 186 1e-47 5HLW-A nrPDB 186 1e-47 6GQK-A nrPDB 186 1e-47 3CJF-A nrPDB 185 2e-47 6E4F-A nrPDB 185 2e-47 5U6B-A nrPDB 185 2e-47 4C59-A nrPDB 185 2e-47 4Y93-A nrPDB 185 2e-47 5HVK-A nrPDB 185 3e-47 3C1X-A nrPDB 185 3e-47 6GVJ-A nrPDB 185 3e-47 3BBT-B nrPDB 184 4e-47 4K33-A nrPDB 184 4e-47 4XLV-A nrPDB 184 4e-47 2HK5-A nrPDB 184 5e-47 1U59-A nrPDB 184 5e-47 5TQX-A nrPDB 183 9e-47 3LLT-A nrPDB 183 1e-46 4HZS-A nrPDB 183 1e-46 4OTD-A nrPDB 183 1e-46 4UY9-A nrPDB 182 2e-46 3PP0-A nrPDB 182 2e-46 5B2L-A nrPDB 182 2e-46 5AP3-A nrPDB 182 2e-46 2OZO-A nrPDB 182 2e-46 5UIU-A nrPDB 182 2e-46 3Q4U-A nrPDB 182 2e-46 6B2Q-A nrPDB 182 2e-46 4X3F-A nrPDB 182 2e-46 4OW8-A nrPDB 182 2e-46 5EG3-A nrPDB 182 2e-46 4UYA-A nrPDB 182 3e-46 6FEX-A nrPDB 182 3e-46 3HMP-A nrPDB 182 3e-46 1U54-B nrPDB 181 4e-46 6BSD-A nrPDB 181 4e-46 3DTC-A nrPDB 181 4e-46 4PL5-B nrPDB 181 4e-46 6HV0-A nrPDB 181 5e-46 5O0Y-A nrPDB 180 6e-46 4H1J-A nrPDB 180 6e-46 5GNK-A nrPDB 180 7e-46 5VD3-A nrPDB 180 9e-46 2OGV-A nrPDB 180 9e-46 4YHJ-A nrPDB 180 1e-45 1K9A-A nrPDB 180 1e-45 3SXS-A nrPDB 180 1e-45 3LZB-A nrPDB 179 2e-45 2ZMD-A nrPDB 179 2e-45 1FVR-A nrPDB 179 2e-45 3PLS-A nrPDB 179 2e-45 3BEA-A nrPDB 179 3e-45 2A1A-B nrPDB 179 3e-45 1BYG-A nrPDB 178 3e-45 3KRL-A nrPDB 178 4e-45 5GRN-A nrPDB 178 4e-45 5U6C-A nrPDB 178 4e-45 5X5O-A nrPDB 177 7e-45 1AD5-A nrPDB 177 7e-45 4CRS-A nrPDB 177 8e-45 4LQP-A nrPDB 177 9e-45 4YFF-A nrPDB 176 1e-44 4R7H-A nrPDB 176 2e-44 3G0E-A nrPDB 176 2e-44 5AMN-A nrPDB 175 2e-44 3DLS-A nrPDB 175 2e-44 2RIO-A nrPDB 175 2e-44 6CTH-A nrPDB 175 3e-44 6FER-A nrPDB 175 3e-44 3MY0-A nrPDB 175 3e-44 4IDT-A nrPDB 175 3e-44 4TPT-A nrPDB 174 5e-44 4LRM-A nrPDB 174 5e-44 3UIU-A nrPDB 174 6e-44 3I81-A nrPDB 174 8e-44 1PY5-A nrPDB 173 1e-43 3QUP-A nrPDB 173 1e-43 3MDY-A nrPDB 172 2e-43 3M42-A nrPDB 172 2e-43 3ZBF-A nrPDB 172 2e-43 4F9B-A nrPDB 171 4e-43 5TOS-A nrPDB 170 7e-43 5FM2-A nrPDB 170 8e-43 4G3E-A nrPDB 170 1e-42 2PMN-X nrPDB 169 2e-42 3QD2-B nrPDB 169 2e-42 3AOX-A nrPDB 169 2e-42 4X7Q-B nrPDB 168 5e-42 5WNL-A nrPDB 167 1e-41 4NEU-A nrPDB 166 1e-41 5TUR-A nrPDB 165 2e-41 3BGP-A nrPDB 165 3e-41 4FL3-A nrPDB 164 5e-41 4RC3-A nrPDB 163 7e-41 2BUJ-A nrPDB 163 9e-41 6J5U-C nrPDB 163 9e-41 5LPZ-A nrPDB 163 1e-40 5LPV-A nrPDB 163 1e-40 5C26-A nrPDB 161 4e-40 5TE0-A nrPDB 160 7e-40 4Y83-A nrPDB 159 2e-39 3SOC-A nrPDB 159 2e-39 4F0G-A nrPDB 158 3e-39 5WNO-A nrPDB 158 3e-39 3ZZW-A nrPDB 157 9e-39 5IKW-A nrPDB 156 1e-38 2QKW-B nrPDB 156 2e-38 4JLC-A nrPDB 154 4e-38 4EUU-A nrPDB 153 7e-38 3UIM-A nrPDB 153 8e-38 4EUT-A nrPDB 152 2e-37 4M66-A nrPDB 151 4e-37 5XD6-A nrPDB 151 5e-37 3LMG-A nrPDB 150 7e-37 3G2F-A nrPDB 150 9e-37 6O8B-A nrPDB 150 1e-36 2H34-A nrPDB 149 2e-36 6NT9-A nrPDB 149 2e-36 2QLU-A nrPDB 147 6e-36 5E8V-A nrPDB 147 6e-36 6BFN-A nrPDB 147 7e-36 2Y4I-B nrPDB 145 2e-35 5AR8-A nrPDB 142 2e-34 3SV0-A nrPDB 141 5e-34 4MWI-A nrPDB 139 2e-33 4TN6-A nrPDB 139 2e-33 5FQD-C nrPDB 138 3e-33 4BTK-A nrPDB 136 2e-32 4NFN-A nrPDB 135 3e-32 4M69-B nrPDB 135 4e-32 5VC6-A nrPDB 135 4e-32 4BTF-A nrPDB 134 5e-32 5X1R-A nrPDB 134 6e-32 3HNG-A nrPDB 131 4e-31 5L2Q-C nrPDB 131 4e-31 2CMW-A nrPDB 130 1e-30 3VHK-A nrPDB 129 2e-30 2CHL-A nrPDB 127 7e-30 4NT4-A nrPDB 127 9e-30 2C47-A nrPDB 125 3e-29 4JRN-A nrPDB 125 3e-29 5X18-A nrPDB 125 5e-29 4RT7-A nrPDB 121 4e-28 4XHH-A nrPDB 119 2e-27 4XHL-A nrPDB 118 3e-27 1CSN-A nrPDB 115 3e-26 5M07-A nrPDB 113 1e-25 5UU1-A nrPDB 88 4e-18 4IX6-A nrPDB 86 2e-17 Sequences not found previously or not previously below threshold: 5J0A-A nrPDB 127 1e-29 5VDK-A nrPDB 125 4e-29 5CEK-A nrPDB 124 5e-29 6DC0-A nrPDB 124 7e-29 2PZI-A nrPDB 111 4e-25 4Y12-A nrPDB 111 5e-25 4L68-A nrPDB 106 2e-23 5USZ-A nrPDB 105 2e-23 5OAT-A nrPDB 104 8e-23 4L00-A nrPDB 100 1e-21 5UV4-A nrPDB 100 2e-21 3REP-A nrPDB 98 8e-21 6EQI-C nrPDB 97 2e-20 6J6I-B nrPDB 95 6e-20 4I94-A nrPDB 89 3e-18 5C01-A nrPDB 88 6e-18 4WOV-A nrPDB 87 9e-18 5CLR-A nrPDB 82 5e-16 2RSV-A nrPDB 80 1e-15 2LAV-A nrPDB 80 2e-15 6G4J-A nrPDB 69 3e-12 4CI6-B nrPDB 67 2e-11 4O1O-A nrPDB 63 2e-10 4OAU-C nrPDB 63 2e-10 5DMZ-A nrPDB 60 2e-09 5GZA-A nrPDB 59 3e-09 6EAS-A nrPDB 57 2e-08 5GZ9-A nrPDB 57 2e-08 4AZW-A nrPDB 56 3e-08 4AZV-A nrPDB 55 3e-08 6EWX-A nrPDB 54 8e-08 4CYJ-A nrPDB 53 1e-07 6G38-A nrPDB 52 4e-07 2JII-A nrPDB 52 5e-07 4WWA-A nrPDB 52 6e-07 6M7Z-A nrPDB 51 8e-07 3ENH-A nrPDB 49 4e-06 6BHC-A nrPDB 48 6e-06 5VE6-A nrPDB 48 7e-06 4BWP-A nrPDB 47 1e-05 3Q60-A nrPDB 46 2e-05 2W1Z-A nrPDB 44 1e-04 3BYV-A nrPDB 44 1e-04 4CZY-B nrPDB 43 3e-04 3DZO-A nrPDB 42 5e-04 1TQM-A nrPDB 36 0.022 5YK0-A nrPDB 36 0.028 6G18-v nrPDB 35 0.058 6FDN-A nrPDB 34 0.10 4BVU-A nrPDB 32 0.34 3FHN-A nrPDB 32 0.36 4BFR-A nrPDB 32 0.51 5CJH-A nrPDB 31 0.94 6EF6-A nrPDB 30 1.6 6DFL-A nrPDB 30 2.5 6FAI-l nrPDB 29 3.4 >3MIA-A nrPDB Length = 351 Score = 480 bits (1236), Expect = e-136, Method: Composition-based stats. Identities = 345/345 (100%), Positives = 345/345 (100%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP Sbjct: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK Sbjct: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS Sbjct: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP Sbjct: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 Query: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK Sbjct: 301 AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 >5EFQ-A nrPDB Length = 347 Score = 355 bits (912), Expect = 2e-98, Method: Composition-based stats. Identities = 150/341 (43%), Positives = 214/341 (62%), Gaps = 8/341 (2%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V K++ + IG+GT+G+V+KAR + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 76 ENVVNLIEICRTKASP--YNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 ++++N+ EI K + + KG+ YLVF++ +HDL GLL + LV F + IK M+ L Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 129 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + GL Y H+ LHRD+K +N+L+ G +KLADFGLAR +S ++ YTN+V+TLW Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEES---RPYTNKVITLW 186 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS++CGS P VW Sbjct: 187 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVW 246 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 P+V + ++ K +RK+++ ALDL D +L LDP++R ++ AL + Sbjct: 247 PDVIKLPYFNTMKPKKQYRRKLREEF--VFIPAAALDLFDYMLALDPSKRCTAEQALQCE 304 Query: 314 FFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQST 354 F D PS + E + RR+ Q+ Sbjct: 305 FL-RDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDD 344 >4NST-A nrPDB Length = 351 Score = 353 bits (905), Expect = 1e-97, Method: Composition-based stats. Identities = 150/335 (44%), Positives = 212/335 (63%), Gaps = 8/335 (2%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V K++ + IG+GT+G+V+KA+ + TG+ VALKKV ++NEKEGFPITA+REIKIL+ L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 76 ENVVNLIEICRTKASP--YNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 +VVN+ EI K + + KG+ YLVF++ +HDL GLL + LV F+ IK M+ L Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 131 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + GL Y H+ LHRD+K +N+L+ G +KLADFGLAR ++ ++ YTN+V+TLW Sbjct: 132 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES---RPYTNKVITLW 188 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YRPPELLLGE Y P ID+W GCI+ E++T+ PI Q N E QL LIS+LCGS P VW Sbjct: 189 YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW 248 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 P+V + ++ K +R++++ ALDL+D +L LDP++R ++ L D Sbjct: 249 PDVIKLPYFNTMKPKKQYRRRLREEFSFIPS--AALDLLDHMLTLDPSKRCTAEQTLQSD 306 Query: 314 FFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQ 348 F D S + H E + RR+ Q Sbjct: 307 FL-KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQ 340 >2BPM-A nrPDB Length = 309 Score = 330 bits (847), Expect = 4e-91, Method: Composition-based stats. Identities = 121/319 (37%), Positives = 178/319 (55%), Gaps = 16/319 (5%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 ++ ++K+ KIG+GT+G V+KAR++ TG+ VALKK+ ++ E EG P TA+REI +L+ L Sbjct: 5 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN 64 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRVMQML 133 H N+V L+++ T + +YLVF+F DL + + L L IK + L Sbjct: 65 HPNIVKLLDVIHT--------ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQL 116 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L GL + H +++LHRD+K N+LI +G +KLADFGLARAF + YT+ VVTLW Sbjct: 117 LQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP----VRTYTHEVVTLW 172 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PE+LLG + Y +D+W GCI AEM TR + G++E QL I + G+ VW Sbjct: 173 YRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVW 232 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 P V + Y+ K ++ + D L+ ++L DP +RI + AL H Sbjct: 233 PGVTSMPDYKP-SFPKWARQDFSKVVPPL--DEDGRSLLSQMLHYDPNKRISAKAALAHP 289 Query: 314 FFWSDPMPSDLKGMLSTHL 332 FF P + H Sbjct: 290 FFQDVTKPVPHLRLERPHR 308 >3NIZ-A nrPDB Length = 311 Score = 327 bits (838), Expect = 5e-90, Method: Composition-based stats. Identities = 120/306 (39%), Positives = 181/306 (59%), Gaps = 16/306 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KY+KL K+G+GT+G V+KA+ + G+ VALK++ ++ E EG P TA+REI +L+ L H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+V+LI++ ++ + LVF+F E DL +L S+IK + LL Sbjct: 79 PNIVSLIDVIHSERC--------LTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLR 130 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ + H+++ILHRD+K N+LI DG LKLADFGLARAF + YT+ VVTLWYR Sbjct: 131 GVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIP----VRSYTHEVVTLWYR 186 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 P++L+G + Y +D+W GCI AEM T P+ G T+ QL I + G+ P WP Sbjct: 187 APDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQ 246 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 V L+++ +K+ + + + +DL+ +L DP +RI + DA+NH +F Sbjct: 247 VQELPLWKQRTFQVFEKKPWSSIIPGFCQ--EGIDLLSNMLCFDPNKRISARDAMNHPYF 304 Query: 316 WSDPMP 321 D P Sbjct: 305 -KDLDP 309 >6GU6-A nrPDB Length = 302 Score = 320 bits (819), Expect = 8e-88, Method: Composition-based stats. Identities = 120/302 (39%), Positives = 180/302 (59%), Gaps = 17/302 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQML 133 N+V+L ++ + +YL+F+F DL L ++ + +K + + Sbjct: 66 PNIVSLQDVLMQDS--------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 117 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L G+ + H ++LHRD+K N+LI G +KLADFGLARAF + YT+ VVTLW Sbjct: 118 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP----IRVYTHEVVTLW 173 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PE+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVW Sbjct: 174 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 233 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 P V++ + Y+ K + + +K D LDL+ K+L+ DPA+RI ALNH Sbjct: 234 PEVESLQDYKN-TFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHP 290 Query: 314 FF 315 +F Sbjct: 291 YF 292 >4AU8-A nrPDB Length = 296 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 124/306 (40%), Positives = 175/306 (57%), Gaps = 17/306 (5%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 KYEKL KIG+GT+G VFKA++R+T + VALK+V ++++ EG P +ALREI +L+ LKH+N Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKN 66 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 +V L ++ + + LVF+FC+ DL + +K + LL GL Sbjct: 67 IVRLHDVLHSDK--------KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 + H +LHRD+K N+LI R+G LKLADFGLARAF + Y+ VVTLWYRPP Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC----YSAEVVTLWYRPP 174 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMW-TRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 ++L G + Y ID+W AGCI AE+ P+ GN QL I +L G+ T E WP++ Sbjct: 175 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 234 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 Y+ + V K + DL+ LL +P QRI +++AL H +F Sbjct: 235 TKLPDYKPYPMYPATTSLVNVVPK---LNATGRDLLQNLLKCNPVQRISAEEALQHPYF- 290 Query: 317 SDPMPS 322 SD P Sbjct: 291 SDFCPP 296 >4IC8-A nrPDB Length = 442 Score = 314 bits (804), Expect = 4e-86, Method: Composition-based stats. Identities = 110/357 (30%), Positives = 168/357 (47%), Gaps = 5/357 (1%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D +YE + IG G +G V AR R TGQ+VA+KK+ + LRE+KIL+ Sbjct: 52 DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF 111 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 KH+N++ + +I R PY K S+Y+V D E DL ++ + TL ++ + L Sbjct: 112 KHDNIIAIKDILR-PTVPYGEFK-SVYVVLDLMESDLHQIIHSS-QPLTLEHVRYFLYQL 168 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L GL Y+H +++HRD+K +N+L+ + LK+ DFG+AR + T V T W Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PEL+L +Y IDLW GCI EM R + G HQL LI + G+ +P V Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 V + ++ + ++ + + D AL L+ ++L +P+ RI + AL H Sbjct: 289 QAVGAERVRAYIQSLPPRQPVPWETVYPG-ADRQALSLLGRMLRFEPSARISAAAALRHP 347 Query: 314 FFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQS-TNQSRNPATTNQTEFE 369 F P D + R I + +R Q F+ Sbjct: 348 FLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQ 404 >4QTB-A nrPDB Length = 380 Score = 313 bits (803), Expect = 6e-86, Method: Composition-based stats. Identities = 109/354 (30%), Positives = 172/354 (48%), Gaps = 9/354 (2%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 + + V+ D +Y +L IG+G +G V A +VA+KK+ E + + Sbjct: 28 EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRT 86 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL 123 LREI+IL +HENV+ + +I R +Y+V D E DL LL + + + Sbjct: 87 LREIQILLRFRHENVIGIRDILRAST---LEAMRDVYIVQDLMETDLYKLLKS--QQLSN 141 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 I + +L GL YIH +LHRD+K +N+LI LK+ DFGLAR + ++ Sbjct: 142 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTG 200 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 T V T WYR PE++L + Y ID+W GCI+AEM + PI G QL I Sbjct: 201 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 260 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 + GS + E + N + L+ + + + +L D ALDL+D++L +P +R Sbjct: 261 ILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPK-SDSKALDLLDRMLTFNPNKR 319 Query: 304 IDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQS 357 I ++AL H + P+D + + T E P+ + ++ Q T + Sbjct: 320 ITVEEALAHPYLEQYYDPTD-EPVAEEPFTFAMELDDLPKERLKELIFQETARF 372 >5NGU-A nrPDB Length = 381 Score = 311 bits (798), Expect = 2e-85, Method: Composition-based stats. Identities = 112/360 (31%), Positives = 170/360 (47%), Gaps = 10/360 (2%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL 64 + V D +Y L+ IG+G +G V A +VA+KK+ E + + L Sbjct: 30 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-SPFEHQTYCQRTL 88 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS 124 REIKIL +HEN++ + +I R +P +Y+V D E DL LL + Sbjct: 89 REIKILLRFRHENIIGINDIIR---APTIEQMKDVYIVQDLMETDLYKLLKT--QHLSND 143 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 I + +L GL YIH +LHRD+K +N+L+ LK+ DFGLAR + + Sbjct: 144 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDHTGF 202 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 T V T WYR PE++L + Y ID+W GCI+AEM + PI G QL I + Sbjct: 203 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGI 262 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 GS + E + N + L + + + +RL D ALDL+DK+L +P +RI Sbjct: 263 LGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPN-ADSKALDLLDKMLTFNPHKRI 321 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTN 364 + + AL H + PSD + + E P+ K ++ + T + P + Sbjct: 322 EVEQALAHPYLEQYYDPSD-EPIAEAPFKFDMELDDLPKEKLKELIFEETAR-FQPGYRS 379 >1V0B-A nrPDB Length = 288 Score = 311 bits (797), Expect = 3e-85, Method: Composition-based stats. Identities = 121/303 (39%), Positives = 169/303 (55%), Gaps = 16/303 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KY L KIG+GT+G V+KA++ G+ ALKK+ +E E EG P T +REI IL+ LKH Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+V L ++ TK + LVF+ + DL LL K + LLN Sbjct: 60 SNIVKLYDVIHTKK--------RLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLN 111 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ Y H ++LHRD+K N+LI R+G LK+ADFGLARAF + +YT+ VVTLWYR Sbjct: 112 GIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIP----VRKYTHEVVTLWYR 167 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 P++L+G + Y ID+W GCI AEM +P+ G +E QL I ++ G+ + WPN Sbjct: 168 APDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPN 227 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 V Y+ V + D +DL+ K+L LDP QRI + AL H +F Sbjct: 228 VTELPKYDPNFTVYE---PLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYF 284 Query: 316 WSD 318 + Sbjct: 285 KEN 287 >4KRC-A nrPDB Length = 317 Score = 311 bits (797), Expect = 3e-85, Method: Composition-based stats. Identities = 116/311 (37%), Positives = 179/311 (57%), Gaps = 22/311 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S++++L K+G GT+ V+K ++ TG VALK+V +++E EG P TA+REI +++ LKHE Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSE-EGTPSTAIREISLMKELKHE 63 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-----NVLVKFTLSEIKRVMQ 131 N+V L ++ T + + LVF+F ++DL + N L+ +K Sbjct: 64 NIVRLYDVIHT--------ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 LL GL + H NKILHRD+K N+LI + G LKL DFGLARAF + N +++ VVT Sbjct: 116 QLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP----VNTFSSEVVT 171 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 LWYR P++L+G R Y ID+W GCI+AEM T P+ G ++ QL LI + G+ Sbjct: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY---ALDLIDKLLVLDPAQRIDSDD 308 +WP+V Y + + R ++ L+ + ++P +D + LL L+P R+ + Sbjct: 232 LWPSVTKLPKYNP-NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Query: 309 ALNHDFFWSDP 319 AL+H +F Sbjct: 291 ALHHPWFAEYY 301 >5Z33-A nrPDB Length = 425 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 101/305 (33%), Positives = 152/305 (49%), Gaps = 9/305 (2%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-H 75 +Y ++GQG +G V A + +T + VA+KKV K+ ALREIK+LQ + H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+ L ++ + +N YL + E DLA ++ + T + + + +L Sbjct: 91 RNITCLYDMDIPRPDNFNET----YLYEELMECDLAAIIRS-GQPLTDAHFQSFIYQILC 145 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL YIH +LHRD+K N+L+ D LK+ DFGLAR FS+ T V T WYR Sbjct: 146 GLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYR 205 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++L + Y ID+W GCI+AE+ P +G QL I + G+ E Sbjct: 206 APEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSR 265 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + + E + + +K L +P ALDL+D++L DP+ RI + AL H + Sbjct: 266 IGSPRAQEYVRNLPFMAKKPFPTLFPN-ANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 Query: 316 --WSD 318 W D Sbjct: 325 HIWHD 329 >4ZSG-A nrPDB Length = 347 Score = 307 bits (786), Expect = 5e-84, Method: Composition-based stats. Identities = 105/310 (33%), Positives = 159/310 (51%), Gaps = 4/310 (1%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D +YE + IG G +G V AR R TGQ+VA+KK+ + LRE+KIL+ Sbjct: 4 DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHF 63 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 KH+N++ + +I R PY K S+Y+V D E DL ++ + TL ++ + L Sbjct: 64 KHDNIIAIKDILR-PTVPYGEFK-SVYVVLDLMESDLHQIIHSS-QPLTLEHVRYFLYQL 120 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L GL Y+H +++HRD+K +N+L+ + LK+ DFG+AR + T V T W Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PEL+L +Y IDLW GCI EM R + G HQL LI + G+ +P V Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 V + ++ + ++ + + D AL L+ ++L +P+ RI + AL H Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPG-ADRQALSLLGRMLRFEPSARISAAAALRHP 299 Query: 314 FFWSDPMPSD 323 F P D Sbjct: 300 FLAKYHDPDD 309 >4AGU-A nrPDB Length = 311 Score = 307 bits (786), Expect = 6e-84, Method: Composition-based stats. Identities = 104/310 (33%), Positives = 167/310 (53%), Gaps = 13/310 (4%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + KYEK+ KIG+G++G VFK R+R TGQ VA+KK L + ALREI++L+ LKH Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+VNL+E+ R K ++LVF++C+H + L +K + L Sbjct: 62 PNLVNLLEVFRRKR--------RLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQ 113 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 + + H++ +HRD+K N+LIT+ V+KL DFG AR + + + V T WYR Sbjct: 114 AVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDE----VATRWYR 169 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PELL+G+ YGPP+D+W GC+ AE+ + P+ G ++ QL LI + G + P Sbjct: 170 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV 229 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + + +++ + + + + P AL L+ L +DP +R+ + L+H +F Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNISYP-ALGLLKGCLHMDPTERLTCEQLLHHPYF 288 Query: 316 WSDPMPSDLK 325 + DL Sbjct: 289 ENIREIEDLA 298 >4BBM-A nrPDB Length = 331 Score = 306 bits (784), Expect = 9e-84, Method: Composition-based stats. Identities = 101/323 (31%), Positives = 172/323 (53%), Gaps = 13/323 (4%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + KYE L +G+G++G V K R++ TG+ VA+KK L ++ + A+REIK+L+ Sbjct: 20 YFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLK 79 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 L+HEN+VNL+E+C+ K YLVF+F +H + L +++ + Sbjct: 80 QLRHENLVNLLEVCKKKKRW--------YLVFEFVDHTILDDLELFPNGLDYQVVQKYLF 131 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 ++NG+ + H + I+HRD+K N+L+++ GV+KL DFG AR + + V T Sbjct: 132 QIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDE----VAT 187 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 WYR PELL+G+ YG +D+W GC++ EM+ P+ G+++ QL I G++ P Sbjct: 188 RWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPR 247 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + ++ + L + ++R+ +R + +DL K L +DP +R + L+ Sbjct: 248 HQELFNKNPVFAGVRLPEIKEREPLERRYPKL-SEVVIDLAKKCLHIDPDKRPFCAELLH 306 Query: 312 HDFFWSDPMPSDLKGMLSTHLTS 334 HDFF D L + Sbjct: 307 HDFFQMDGFAERFSQELQLKVQK 329 >4EWQ-A nrPDB Length = 383 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 96/312 (30%), Positives = 154/312 (49%), Gaps = 12/312 (3%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + +Y+ L+ +G G +G V A KTG +VA+KK+ + RE+++L+ Sbjct: 40 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 99 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 +KHENV+ L+++ S +YLV DL ++ K T ++ ++ Sbjct: 100 HMKHENVIGLLDVFTPARSLEEF--NDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIY 155 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L GL YIH I+HRD+K +N+ + D LK+ DFGLAR + T V T Sbjct: 156 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-------TDDEMTGYVAT 208 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 WYR PE++L Y +D+W GCIMAE+ T + G QL LI +L G+ E Sbjct: 209 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 268 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + + + ++ + + + +P A+DL++K+LVLD +RI + AL Sbjct: 269 LLKKISSESARNYIQSLTQMPKMNFANVF-IGANPLAVDLLEKMLVLDSDKRITAAQALA 327 Query: 312 HDFFWSDPMPSD 323 H +F P D Sbjct: 328 HAYFAQYHDPDD 339 >1UA2-A nrPDB Length = 346 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 125/357 (35%), Positives = 186/357 (52%), Gaps = 20/357 (5%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM---ENEKEGFPITAL 64 + +YEKL +G+G F V+KAR + T Q VA+KK+ + K+G TAL Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS 124 REIK+LQ L H N++ L++ K+ +I LVFDF E DL ++ + + T S Sbjct: 61 REIKLLQELSHPNIIGLLDAFGHKS--------NISLVFDFMETDLEVIIKDNSLVLTPS 112 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 IK M M L GL Y+H++ ILHRD+K N+L+ +GVLKLADFGLA++F + Sbjct: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA---- 168 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 YT++VVT WYR PELL G R YG +D+W GCI+AE+ R P + G+++ QL I + Sbjct: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 G+ T E WP++ + Y + G + LDLI L + +P RI Sbjct: 229 LGTPTEEQWPDMCSLPDYVTFKSFPG----IPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHL-TSMFEYLAPPRRKGSQITQQSTNQSRNP 360 + AL +F + P P+ + + + + P + ++ Q P Sbjct: 285 TATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLP 341 >1CM8-A nrPDB Length = 367 Score = 303 bits (776), Expect = 7e-83, Method: Composition-based stats. Identities = 100/309 (32%), Positives = 158/309 (51%), Gaps = 12/309 (3%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y L +G G +G V A +TG KVA+KK+ + E F A RE+++L+ ++HENV Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + L+++ + + YLV F DL L+ + K I+ ++ +L GL Sbjct: 87 IGLLDVFTPDETLDDFT--DFYLVMPFMGTDLGKLMKH--EKLGEDRIQFLVYQMLKGLR 142 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 YIH I+HRD+K N+ + D LK+ DFGLAR + T VVT WYR PE Sbjct: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-------ADSEMTGYVVTRWYRAPE 195 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 ++L Y +D+W GCIMAEM T + +G+ QL I ++ G+ E + + Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSD 318 E ++ + ++K + P A++L++K+LVLD QR+ + +AL H +F S Sbjct: 256 DEAKNYMKGLPELEKKDFASILTN-ASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314 Query: 319 PMPSDLKGM 327 D + Sbjct: 315 HDTEDEPQV 323 >3OHT-A nrPDB Length = 389 Score = 303 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 94/312 (30%), Positives = 156/312 (50%), Gaps = 12/312 (3%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + +Y+ L+ +G G +G V + K+G K+A+KK+ + RE+++L+ Sbjct: 46 IWEVPERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLK 105 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 +KHENV+ L+++ S +YLV DL ++ K T ++ ++ Sbjct: 106 HMKHENVIGLLDVFTPATSLEEF--NDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIY 161 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L GL YIH I+HRD+K +N+ + D LK+ DFGLAR + T V T Sbjct: 162 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-------TDDEMTGYVAT 214 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 WYR PE++L Y +D+W GCIMAE+ T + G +QL I +L G+ Sbjct: 215 RWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAS 274 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 V + ++E + + ++ + +P A+DL++K+LVLD +RI + +AL Sbjct: 275 VISRMPSHEARNYINSLPQMPKRNFADVF-IGANPLAVDLLEKMLVLDTDKRITASEALA 333 Query: 312 HDFFWSDPMPSD 323 H +F P D Sbjct: 334 HPYFSQYHDPDD 345 >2F9G-A nrPDB Length = 353 Score = 301 bits (770), Expect = 4e-82, Method: Composition-based stats. Identities = 94/314 (29%), Positives = 165/314 (52%), Gaps = 14/314 (4%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S ++ + +G+G +G V A H+ TG+ VA+KK+ +K F + LREIKIL+ KHE Sbjct: 11 SDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHE 69 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 N++ + I + +Y++ + + DL ++S + + I+ + L Sbjct: 70 NIITIFNI---QRPDSFENFNEVYIIQELMQTDLHRVISTQM--LSDDHIQYFIYQTLRA 124 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA------KNSQPNRYTNRVV 190 + +H + ++HRD+K +N+LI + LK+ DFGLAR + Q + T V Sbjct: 125 VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVA 184 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI-T 249 T WYR PE++L Y +D+W GCI+AE++ R PI G +HQL LI + G+ + Sbjct: 185 TRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS 244 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 +++ E ++ + +++ V +P +DL+ ++LV DPA+RI + +A Sbjct: 245 DNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRV-NPKGIDLLQRMLVFDPAKRITAKEA 303 Query: 310 LNHDFFWSDPMPSD 323 L H + + P+D Sbjct: 304 LEHPYLQTYHDPND 317 >6DTL-A nrPDB Length = 364 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 105/355 (29%), Positives = 170/355 (47%), Gaps = 20/355 (5%) Query: 12 FCDEVSKYEK-LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 + +KY+ + IG+G +G V A + +T + VA+KK+ + + LREIK+L Sbjct: 24 IFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLL 83 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM 130 + + HEN+V + +I P +Y+ ++ + DL ++ + + + + Sbjct: 84 RHMDHENIVAIRDII---PPPLRNAFNDVYIAYELMDTDLHQIIRSNQA-LSEEHCQYFL 139 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +L GL YIH +LHRD+K +N+L+ + LK+ DFGLAR S+ + T VV Sbjct: 140 YQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARV-----TSESDFMTEYVV 194 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T WYR PELLL DY ID+W GCI E+ R P+ G HQL L+ +L G+ + Sbjct: 195 TRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSE 254 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E ++ +L ++ + D+ P A+DLI+K+L DP +RI DAL Sbjct: 255 EELEFLNENAKRYIRQLPPYPRQSITDKFPTV--HPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQ---SRNPAT 362 H + S SD T F + + ++ + + NP Sbjct: 313 AHPYLNSLHDISD-----EPECTIPFNFDFENHALSEEQMKELIYREALAFNPEY 362 >4MYG-A nrPDB Length = 372 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 97/299 (32%), Positives = 155/299 (51%), Gaps = 13/299 (4%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +G G +G V A +++G+KVA+KK+ + E F A RE+ +L+ ++HENV+ L+++ Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNK 144 +S N YLV F + DL ++ ++F+ +I+ ++ +L GL YIH Sbjct: 111 FTPASSLRNFY--DFYLVMPFMQTDLQKIMG---MEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 145 ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER 204 ++HRD+K N+ + D LK+ DFGLAR T VVT WYR PE++L Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLARH-------ADAEMTGYVVTRWYRAPEVILSWM 218 Query: 205 DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEK 264 Y +D+W GCIMAEM T + +G QL I ++ G E +++ Sbjct: 219 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 278 Query: 265 LELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323 ++ + RK +L P A DL++K+L LD +R+ + AL H FF P + Sbjct: 279 IQSLPQTPRKDFTQLFP-RASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 336 >3GC9-A nrPDB Length = 370 Score = 294 bits (753), Expect = 4e-80, Method: Composition-based stats. Identities = 93/311 (29%), Positives = 154/311 (49%), Gaps = 12/311 (3%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 + + + L +G G +G V A + QKVA+KK+ + RE+++L+ Sbjct: 24 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 83 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 LKHENV+ L+++ S + + +YLV DL ++ + + ++ ++ Sbjct: 84 LKHENVIGLLDVFTPATSIEDFSE--VYLVTTLMGADLNNIVKS--QALSDEHVQFLVYQ 139 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 LL GL YIH I+HRD+K +NV + D L++ DFGLAR T V T Sbjct: 140 LLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQ-------ADEEMTGYVATR 192 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 WYR PE++L Y +D+W GCIMAE+ + G+ QL I ++ G+ +PEV Sbjct: 193 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 252 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 + + ++ + +K + +P A+DL+ ++LVLD QR+ + +AL H Sbjct: 253 LAKISSEHARTYIQSLPPMPQKDLSSIFRG-ANPLAIDLLGRMLVLDSDQRVSAAEALAH 311 Query: 313 DFFWSDPMPSD 323 +F P D Sbjct: 312 AYFSQYHDPED 322 >5G6V-A nrPDB Length = 324 Score = 293 bits (750), Expect = 8e-80, Method: Composition-based stats. Identities = 122/302 (40%), Positives = 172/302 (56%), Gaps = 15/302 (4%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + Y KL K+G+GT+ V+K + + T VALK++ +E+E EG P TA+RE+ +L+ LKH Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 59 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+V L +I T+ S+ LVF++ + DL L + + +K + LL Sbjct: 60 ANIVTLHDIIHTEK--------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLR 111 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL Y HR K+LHRD+K N+LI G LKLADFGLARA S+ Y N VVTLWYR Sbjct: 112 GLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP----TKTYDNEVVTLWYR 167 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PP++LLG DY ID+WG GCI EM T P+ G+T + QL I ++ G+ T E WP Sbjct: 168 PPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPG 227 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + + E ++ K + + D DL+ KLL + RI ++DA+ H FF Sbjct: 228 ILSNEEFKTYNYPKYRAEALLSHAPRL--DSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 Query: 316 WS 317 S Sbjct: 286 LS 287 >3ZDU-A nrPDB Length = 325 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 103/335 (30%), Positives = 171/335 (51%), Gaps = 16/335 (4%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + YE L K+G+G++G V K +H+ TGQ VA+K + E ++ A+REIK L+ H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 EN+VNLIE+ R K I+LVF+F +H + L + +++ + +L Sbjct: 61 ENLVNLIEVFRQKK--------KIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILR 112 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 + Y+H N I+HRD+K N+L+++ G+ KL DFG AR + + + V T WYR Sbjct: 113 AIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDE----VATRWYR 168 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PEL+L + YG P+D+W GC++ EM T +P + +++ L I G+++P + Sbjct: 169 APELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNI 228 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 ++ + L + Q K + + A D++ L +DPA RI S D L+H++F Sbjct: 229 FSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLA-DIVHACLQIDPADRISSSDLLHHEYF 287 Query: 316 WSDPMPSDLKGMLSTHLTSMFEYLA--PPRRKGSQ 348 D L L + + P+ + Sbjct: 288 TRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKE 322 >4BGQ-A nrPDB Length = 304 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 108/313 (34%), Positives = 165/313 (52%), Gaps = 13/313 (4%) Query: 7 SVECP-FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 S++ P + ++K+E L +G+G +G V K RH++T + VA+KK E E T LR Sbjct: 1 SMKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLR 60 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE 125 E+K+L+ LK EN+V L E R +G +YLVF++ E ++ LL + + Sbjct: 61 ELKMLRTLKQENIVELKEAFR--------RRGKLYLVFEYVEKNMLELLEEMPNGVPPEK 112 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 +K + L+ +++ H+N I+HRD+K N+LI+ + VLKL DFG AR S N+ Y Sbjct: 113 VKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNA---NY 169 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 V T WYR PELLLG YG +D+W GCI+ E+ P+ G +E QL I ++ Sbjct: 170 DEEVATRWYRSPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVL 228 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 G + E + + L + +R + + LDL+ LL LDPA R Sbjct: 229 GPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYL 288 Query: 306 SDDALNHDFFWSD 318 ++ LNH F + Sbjct: 289 TEQCLNHPTFQTQ 301 >3OZ6-A nrPDB Length = 388 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 107/343 (31%), Positives = 170/343 (49%), Gaps = 41/343 (11%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 + KYE + K+G+G +G V+K+ R+TG+ VA+KK+ + REI IL L Sbjct: 6 HVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTEL 65 Query: 74 K-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 HEN+VNL+ + R +YLVFD+ E DL ++ + + V+ Sbjct: 66 SGHENIVNLLNVLRADNDR------DVYLVFDYMETDLHAVIRANI--LEPVHKQYVVYQ 117 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF-----------------S 175 L+ + Y+H +LHRDMK +N+L+ + +K+ADFGL+R+F + Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENT 177 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 + T+ V T WYR PE+LLG Y ID+W GCI+ E+ PI G++ Sbjct: 178 ENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTM 237 Query: 236 HQLALISQLCGSITPEVWPNVDN-------YELYEKLELVKGQKRKVKDRLKAYVR---- 284 +QL I + + E ++ + L EK+E+ + KR + + K + Sbjct: 238 NQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINP 297 Query: 285 ----DPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323 + ALDL+DKLL +P +RI ++DAL H F P++ Sbjct: 298 KADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNE 340 >1G3N-A nrPDB Length = 326 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 112/311 (36%), Positives = 168/311 (54%), Gaps = 19/311 (6%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARH-RKTGQKVALKKVLMENEKEGFPITALREIKIL 70 C +YE +A+IG+G +G+VFKAR + G+ VALK+V ++ +EG P++ +RE+ +L Sbjct: 6 LCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVL 65 Query: 71 QLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEI 126 + L+ H NVV L ++C + + + LVF+ + DL L V I Sbjct: 66 RHLETFEHPNVVRLFDVCTVSRT---DRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETI 122 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 K +M LL GL ++H ++++HRD+K N+L+T G +KLADFGLAR +S T Sbjct: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-----QMALT 177 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + VVTLWYR PE+LL + Y P+DLW GCI AEM+ R P+ +G+++ QL I + G Sbjct: 178 SVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG 236 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 E WP K + D DL+ K L +PA+RI + Sbjct: 237 LPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDI-----DELGKDLLLKCLTFNPAKRISA 291 Query: 307 DDALNHDFFWS 317 AL+H +F Sbjct: 292 YSALSHPYFQD 302 >3NCG-A nrPDB Length = 486 Score = 288 bits (738), Expect = 2e-78, Method: Composition-based stats. Identities = 89/364 (24%), Positives = 161/364 (44%), Gaps = 55/364 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +Y + +G+G+FGEV K + R T Q+ A+K + + K T LRE+++L+ L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQML 133 N++ L EI + S Y+V + + L ++ +F+ + R+++ + Sbjct: 81 PNIMKLFEILEDSS--------SFYIVGEL--YTGGELFDEIIKRKRFSEHDAARIIKQV 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H++ I+HRD+K N+L+ +D +K+ DFGL+ F Q + +R+ Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-----QNTKMKDRIG 185 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y PE+L G Y D+W AG I+ + + +P G E L + + Sbjct: 186 TAYYIAPEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDL 243 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W + + A DLI K+L P+ RI + L Sbjct: 244 PQWRTISD----------------------------DAKDLIRKMLTFHPSLRITATQCL 275 Query: 311 NHDFFW----SDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQT 366 H + P SDL L + +T++ ++ A + + + ++ + T T Sbjct: 276 EHPWIQKYSSETPTISDL-PSLESAMTNIRQFQAEKKLAQAALLYMASKLTTLDETKQLT 334 Query: 367 EFER 370 E R Sbjct: 335 EIFR 338 >3GC0-A nrPDB Length = 329 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 105/317 (33%), Positives = 177/317 (55%), Gaps = 21/317 (6%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P + +Y ++ K+G+GT+GEV+KA T + VA+K++ +E+E+EG P TA+RE+ +L Sbjct: 28 PSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLL 87 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVM 130 + L+H N++ L + ++L+F++ E+DL + ++ IK + Sbjct: 88 KELQHRNIIELKSVIHHN--------HRLHLIFEYAENDLKKYMDKNPD-VSMRVIKSFL 138 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLIT-----RDGVLKLADFGLARAFSLAKNSQPNRY 185 L+NG+ + H + LHRD+K N+L++ VLK+ DFGLARAF + ++ Sbjct: 139 YQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIP----IRQF 194 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 T+ ++TLWYRPPE+LLG R Y +D+W CI AEM ++P+ G++E QL I ++ Sbjct: 195 THEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVL 254 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 G WP V +++ K + + +K L A + D + +L +DP +RI Sbjct: 255 GLPDDTTWPGVTALPDWKQ-SFPKFRGKTLKRVLGALLDDEGLDL-LTAMLEMDPVKRIS 312 Query: 306 SDDALNHDFFWS-DPMP 321 + +AL H +F D P Sbjct: 313 AKNALEHPYFSHNDFDP 329 >4O2Z-A nrPDB Length = 377 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 95/328 (28%), Positives = 154/328 (46%), Gaps = 10/328 (3%) Query: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT 62 K Y+ PF + SKY L +G G +G TG+KV++KK Sbjct: 32 KVYNVSGSPF-EVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKR 90 Query: 63 ALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 LREI +++ HEN++N++ I Y+ + +Y+V + D+ +L + V Sbjct: 91 VLREIDMMRFFHHENLLNVVNILPPLKREYHSFED-VYVVTPLMDVDMNVVLRSRQV-LE 148 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 S ++ + +L GL Y+H + HRD+K AN++ LK+ DFGL+R+ + Sbjct: 149 ESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVP----Y 204 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + T+ V+T WYRPPELLL +Y +D+W GCI AEM+ R P+ G QL +I+ Sbjct: 205 SELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIA 264 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 Q G + V++ E EKL + + + + +D + K+ LDP++ Sbjct: 265 QHIGKPPASI---VEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSK 321 Query: 303 RIDSDDALNHDFFWSDPMPSDLKGMLST 330 R + D L H + D Sbjct: 322 RPTAADMLAHPYLAHLHDEEDEPTCPCP 349 >4QNY-A nrPDB Length = 354 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 97/326 (29%), Positives = 156/326 (47%), Gaps = 11/326 (3%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARH-RKTGQKVALKKVLME-NEKEGF 59 K ++ C +Y IG G++G V +AR + + VA+K+V E E+ Sbjct: 5 TKSLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVIL 64 Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 LREIK+L +N++ L I + Y+V D E DL +L + Sbjct: 65 AKRILREIKLLAHFNDDNIIGLRNILTPEDPENF---DHFYIVMDIMETDLKQVLRS-GQ 120 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 + T + I+ + L L+ IH ++HRD+ AN+L+ + LK+ DFGLA+ +N Sbjct: 121 ELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKE----EN 176 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 Q T+ V WYR PEL++ ++DY ID+WG GCI+ E+ P+ QG +QL Sbjct: 177 DQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLD 236 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 I + G+ + E +V + + L+ K + + R + P ALDL+ +LV + Sbjct: 237 KIVDVIGTPSEEDINSVGSSAAQKYLK-KKSHRPQADWRQRYPTASPEALDLLRHMLVFN 295 Query: 300 PAQRIDSDDALNHDFFWSDPMPSDLK 325 P +RI A+ H F +D Sbjct: 296 PKRRITVLQAMRHPFLEQLHDDADDN 321 >2W96-B nrPDB Length = 306 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 112/307 (36%), Positives = 164/307 (53%), Gaps = 18/307 (5%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK- 74 S+YE +A+IG G +G V+KAR +G VALK V + N +EG PI+ +RE+ +L+ L+ Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEA 62 Query: 75 --HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSN-VLVKFTLSEIKRVMQ 131 H NVV L+++C T + + + LVF+ + DL L IK +M+ Sbjct: 63 FEHPNVVRLMDVCATSRT---DREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 119 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L GL ++H N I+HRD+K N+L+T G +KLADFGLAR +S P VVT Sbjct: 120 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPV-----VVT 174 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 LWYR PE+LL + Y P+D+W GCI AEM+ R P+ GN+E QL I L G + Sbjct: 175 LWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 233 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 WP + + R V+ + + L+ ++L +P +RI + AL Sbjct: 234 DWPRDVSLP---RGAFPPRGPRPVQSVVPEM--EESGAQLLLEMLTFNPHKRISAFRALQ 288 Query: 312 HDFFWSD 318 H + D Sbjct: 289 HSYLHKD 295 >1JNK-A nrPDB Length = 423 Score = 283 bits (724), Expect = 8e-77, Method: Composition-based stats. Identities = 87/344 (25%), Positives = 154/344 (44%), Gaps = 21/344 (6%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+++L+ + + + +YLV + + +L + ++ + ++ +L Sbjct: 121 KNIISLLNVFTPQKTLEEF--QDVYLVMELMDANL---CQVIQMELDHERMSYLLYQMLC 175 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR T VVT +YR Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----AGTSFMMTPYVVTRYYR 230 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 231 APEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 289 Query: 256 --------VDNYELYEKLELVK--GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 V+N Y L K D ++ A DL+ K+LV+DPA+RI Sbjct: 290 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 349 Query: 306 SDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQI 349 DDAL H + P++++ + + ++ Sbjct: 350 VDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKEL 393 >5AWM-A nrPDB Length = 394 Score = 281 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 96/363 (26%), Positives = 153/363 (42%), Gaps = 26/363 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S+Y L IG G G V A T Q VA+KK+ + A RE K+++L+ H+ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHK 103 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 N++ L+ + + +YLV + + +L + + + ++ +L G Sbjct: 104 NIIGLLNAFTPQRNLEEF--QDVYLVMELMDANL---CQVIQMDLDHDRMSYLLYQMLCG 158 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 + ++H I+HRD+K +N+++ D LK+ DFGLAR T VVT +YR Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART-----AGTTFMMTPYVVTRYYRA 213 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW--- 253 PE++LG Y +D+W GCIM EM + G Q I + G+ +P Sbjct: 214 PEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL 272 Query: 254 -PNVDNYELYEKLELVKGQKRKVKDRLKAYVRD-------PYALDLIDKLLVLDPAQRID 305 P V NY R D L + A +L+ K+LV+DP QRI Sbjct: 273 QPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRIS 332 Query: 306 SDDALNHDFF--WSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATT 363 D+AL H++ W D D + + ++ + T Sbjct: 333 VDEALKHEYINVWYDAEEVDAPAPEP--YDHSVDEREHTVEQWKELIYEEVMDYEAHNTN 390 Query: 364 NQT 366 N+T Sbjct: 391 NRT 393 >3E7O-A nrPDB Length = 360 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 91/344 (26%), Positives = 160/344 (46%), Gaps = 21/344 (6%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y++L IG G G V A G VA+KK+ + + A RE+ +L+ + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+++L+ + + + +YLV + + +L ++ L +S ++ +L Sbjct: 81 KNIISLLNVFTPQKTLEEF--QDVYLVMELMDANLCQVIHMELDHERMS---YLLYQMLC 135 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR S T VVT +YR Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFM-----MTPYVVTRYYR 190 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT------ 249 PE++LG Y +D+W GCIM E+ S I QG Q + + G+ + Sbjct: 191 APEVILG-MGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAA 249 Query: 250 --PEVWPNVDNYELYE--KLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 P V V+N Y E + + + ++ A DL+ K+LV+DP +RI Sbjct: 250 LQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS 309 Query: 306 SDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQI 349 D+AL H + P++ + + E + ++ Sbjct: 310 VDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKEL 353 >2XS0-A nrPDB Length = 386 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 85/324 (26%), Positives = 148/324 (45%), Gaps = 23/324 (7%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N++ L+ + + S +Y+V + + +L + ++ + ++ +L Sbjct: 85 KNIIGLLNVFTPQKSLEEF--QDVYIVMELMDANL---CQVIQMELDHERMSYLLYQMLC 139 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR + P VVT +YR Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVP-----FVVTRYYR 194 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 195 APEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKK 253 Query: 256 --------VDNYELYEKLELVK--GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 V+N Y K D ++ A DL+ K+LV+D ++RI Sbjct: 254 LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS 313 Query: 306 SDDALNHDFF--WSDPMPSDLKGM 327 D+AL H + W DP ++ Sbjct: 314 VDEALQHPYINVWYDPSEAEAPPP 337 >3FI2-A nrPDB Length = 353 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 86/310 (27%), Positives = 145/310 (46%), Gaps = 21/310 (6%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +Y+ L IG G G V A + VA+KK+ + + A RE+ +++ + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+++L+ + + + +YLV + + +L + ++ + ++ +L Sbjct: 83 KNIISLLNVFTPQKTLEEF--QDVYLVMELMDANL---CQVIQMELDHERMSYLLYQMLC 137 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ ++H I+HRD+K +N+++ D LK+ DFGLAR T VVT +YR Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----AGTSFMMTPYVVTRYYR 192 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++LG Y +D+W GCIM EM + G Q + + G+ PE Sbjct: 193 APEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKK 251 Query: 256 --------VDNYELYEKLELVK--GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 V+N Y L K D ++ A DL+ K+LV+DPA+RI Sbjct: 252 LQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS 311 Query: 306 SDDALNHDFF 315 DDAL H + Sbjct: 312 VDDALQHPYI 321 >3PG1-A nrPDB Length = 362 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 90/322 (27%), Positives = 146/322 (45%), Gaps = 18/322 (5%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG---------FPITALREIKI 69 Y I G++G V + G VA+K+V LREI++ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 L H N++ L +I P +YLV + DLA ++ + + + I+ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEP---AMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYF 139 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 M +L GL+ +H ++HRD+ N+L+ + + + DF LAR +++ T+ V Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAR-----EDTADANKTHYV 194 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 WYR PEL++ + + +D+W AGC+MAEM+ R + +G+T +QL I ++ G+ Sbjct: 195 THRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPK 254 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 E + + L DP ALDLI K+L +P +RI ++ A Sbjct: 255 IEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQA 314 Query: 310 LNHDFFWSDPMPSDLKGMLSTH 331 L H +F S P DL LS Sbjct: 315 LRHPYFESLFDPLDLTEGLSER 336 >5JN2-A nrPDB Length = 525 Score = 276 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 85/358 (23%), Positives = 160/358 (44%), Gaps = 54/358 (15%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG-FPITALREIKILQLLKH 75 +Y+ +G+G+FGEV + + TGQ+ A+K + K+ + LRE+++L+ L H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFD-FCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 N++ L E KG YLV + + +L + + +F+ + R+++ +L Sbjct: 127 PNIMKLYEFFED--------KGYFYLVGEVYTGGELFDEIIS-RKRFSEVDAARIIRQVL 177 Query: 135 NGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +G+ Y+H+NKI+HRD+K N+L+ ++D +++ DFGL+ F +K + +++ T Sbjct: 178 SGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK-----KMKDKIGT 232 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y PE+L G Y D+W G I+ + + P G E L + + + Sbjct: 233 AYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELP 290 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V A DLI K+L P+ RI + DAL+ Sbjct: 291 QWKKV----------------------------SESAKDLIRKMLTYVPSMRISARDALD 322 Query: 312 HDFFWSDPMP--SDLKGMLSTHLTSMFEYLAPPRRKGSQIT---QQSTNQSRNPATTN 364 H++ + S L + ++ ++ + + + + T+Q T Sbjct: 323 HEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKELTA 380 >3DFA-A nrPDB Length = 286 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 138/307 (44%), Gaps = 50/307 (16%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +Y + +G+G+FGEV K + R T Q+ A+K + + K T LRE+++L+ L H Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH 80 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQML 133 N++ L EI + S Y+V + + L ++ + F+ + R+++ + Sbjct: 81 PNIMKLFEILEDSS--------SFYIVGEL--YTGGELFDEIIKRKRFSEHDAARIIKQV 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H++ I+HRD+K N+L+ +D +K+ DFGL+ F Q + +R+ Sbjct: 131 FSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQ-----QNTKMKDRIG 185 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y PE+L G Y D+W AG I+ + + +P G E L + + Sbjct: 186 TAYYIAPEVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDL 243 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W + + A DLI K+L P+ RI + L Sbjct: 244 PQWRTISD----------------------------DAKDLIRKMLTFHPSLRITATQCL 275 Query: 311 NHDFFWS 317 H + Sbjct: 276 EHPWIQK 282 >3RP9-A nrPDB Length = 458 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 103/373 (27%), Positives = 162/373 (43%), Gaps = 63/373 (16%) Query: 2 AKQYDSVECPFCD--EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF 59 +K S+ P D +YE IG G++G V +A + + VA+KK+L E Sbjct: 36 SKPTASMPRPHSDWQIPDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLID 95 Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 LREI IL L H++VV +++I K +Y+V + + D L + Sbjct: 96 CKRILREIAILNRLNHDHVVKVLDIVIPKD---VEKFDELYVVLEIADSDFKKLFRTPVY 152 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 T IK ++ LL G+ Y+H ILHRD+K AN L+ +D +K+ DFGLAR +N Sbjct: 153 -LTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPEN 211 Query: 180 SQPN-----------------------RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAG 216 + T VVT WYR PEL+L + +Y ID+W G Sbjct: 212 GNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIG 271 Query: 217 CIMAEMWT-----------RSPIMQGNT--------------------EQHQLALISQLC 245 CI AE+ R P+ G++ + QL +I + Sbjct: 272 CIFAELLNMIKENVAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNIL 331 Query: 246 GSITPEVWPNVDNYELYEKLE-LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 G+ + E ++ + + K + + +R A D A+ L+ ++LV +P +RI Sbjct: 332 GTPSEEDIEALEKEDAKRYIRIFPKREGTDLAERFPASSAD--AIHLLKRMLVFNPNKRI 389 Query: 305 DSDDALNHDFFWS 317 ++ L H FF Sbjct: 390 TINECLAHPFFKE 402 >3LIJ-A nrPDB Length = 494 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 80/360 (22%), Positives = 151/360 (41%), Gaps = 53/360 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+++ K+G G +GEV R + T + A+K + + L E+ +L+LL H N+ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNI 98 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR--VMQMLLNG 136 + L + K + YLV + + L ++ + +E+ +++ +L+G Sbjct: 99 MKLYDFFEDKRNY--------YLVME--CYKGGELFDEIIHRMKFNEVDAAVIIKQVLSG 148 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y+H++ I+HRD+K N+L+ +D ++K+ DFGL+ F K + R+ T + Sbjct: 149 VTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQK-----KMKERLGTAY 203 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L + Y D+W G I+ + P G T+Q L + + + W Sbjct: 204 YIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEW 261 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 NV A DLI ++L D +RI + AL H Sbjct: 262 KNV----------------------------SEGAKDLIKQMLQFDSQRRISAQQALEHP 293 Query: 314 FFW---SDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFER 370 + S L+ + +M ++ + + + ++ + T T+ R Sbjct: 294 WIKEMCSKKESGIELPSLANAIENMRKFQNSQKLAQAALLYMASKLTSQEETKELTDIFR 353 >3HZT-A nrPDB Length = 467 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 85/363 (23%), Positives = 158/363 (43%), Gaps = 54/363 (14%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKH 75 +Y+++ K+G G +GEV + + TG + A+K + + L E+ +L+ L H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQML 133 N++ L E K + YLV + + L ++ KF+ + +M+ + Sbjct: 64 PNIMKLYEFFEDKRNY--------YLVMEV--YRGGELFDEIILRQKFSEVDAAVIMKQV 113 Query: 134 LNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L+G Y+H++ I+HRD+K N+L+ +RD ++K+ DFGL+ F + + R+ Sbjct: 114 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-----GKMKERLG 168 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y PE+L + Y D+W G I+ + P G T+Q L + + S P Sbjct: 169 TAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDP 226 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V + A L+ +L +P++RI +++AL Sbjct: 227 PDWTQVSD----------------------------EAKQLVKLMLTYEPSKRISAEEAL 258 Query: 311 NHDF---FWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTE 367 NH + F S K L+ L +M ++ + + + + + + T T+ Sbjct: 259 NHPWIVKFCSQKHTDVGKHALTGALGNMKKFQSSQKLAQAAMLFMGSKLTTLEETKELTQ 318 Query: 368 FER 370 R Sbjct: 319 IFR 321 >3MA6-A nrPDB Length = 298 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 80/306 (26%), Positives = 145/306 (47%), Gaps = 49/306 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG-FPITALREIKILQLLKH 75 +Y+ +G+G+FGEV + + TGQ+ A+K + K+ + LRE+++L+ L H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFD-FCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 N++ L E KG YLV + + +L + + +F+ + R+++ +L Sbjct: 92 PNIMKLYEFFED--------KGYFYLVGEVYTGGELFDEIIS-RKRFSEVDAARIIRQVL 142 Query: 135 NGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +G+ Y+H+NKI+HRD+K N+L+ ++D +++ DFGL+ F +K + +++ T Sbjct: 143 SGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK-----KMKDKIGT 197 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y PE+L G Y D+W G I+ + + P G E L + + + Sbjct: 198 AYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELP 255 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V A DLI K+L P+ RI + DAL+ Sbjct: 256 QWKKV----------------------------SESAKDLIRKMLTYVPSMRISARDALD 287 Query: 312 HDFFWS 317 H++ + Sbjct: 288 HEWIQT 293 >5WAX-A nrPDB Length = 310 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 82/357 (22%), Positives = 147/357 (41%), Gaps = 50/357 (14%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 S++ P + +YE + IG G FG R+R GQ VA+K + E RE Sbjct: 1 SMDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI---ERGEKIDENVQRE 57 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE 125 I + L+H N++ E+ T + +V ++ +L + N +F+ E Sbjct: 58 IINHRSLRHPNIIRFKEVILTPT--------HLAIVMEYASGGELFERICNA-GRFSEDE 108 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPN 183 + Q L++G+ Y H ++ HRD+K N L+ LK+ DFG ++ + + Sbjct: 109 ARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK-----SSVLHS 163 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 + + V T Y PE+LL + G D+W G + M + + E Sbjct: 164 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDE--------- 214 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 + ++ + G + + D + P DLI ++ V +PA R Sbjct: 215 --------------PKNFRKTIQRILGVQYSIPDYVH---ISPECQDLISRIFVANPATR 257 Query: 304 IDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360 I + NH +F + +P+DL M + ++ +E P + +I Q ++ P Sbjct: 258 ITIPEIRNHPWFLKN-LPADL--MDDSTMSKQYEEPEQPMQSMDEIM-QILAEATIP 310 >3DXN-A nrPDB Length = 287 Score = 267 bits (682), Expect = 7e-72, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 138/305 (45%), Gaps = 51/305 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKH 75 +Y+++ K+G G +GEV + + TG + A+K + + L E+ +L+ L H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVMQML 133 N++ L E K + YLV + + L ++ KF+ + +M+ + Sbjct: 81 PNIMKLYEFFEDKRNY--------YLVMEV--YRGGELFDEIILRQKFSEVDAAVIMKQV 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L+G Y+H++ I+HRD+K N+L+ +RD ++K+ DFGL+ F + + R+ Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-----GKMKERLG 185 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y PE+L + Y D+W G I+ + P G T+Q L + + S P Sbjct: 186 TAYYIAPEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDP 243 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V + A L+ +L +P++RI +++AL Sbjct: 244 PDWTQVSD----------------------------EAKQLVKLMLTYEPSKRISAEEAL 275 Query: 311 NHDFF 315 NH + Sbjct: 276 NHPWI 280 >5AIR-A nrPDB Length = 430 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 91/315 (28%), Positives = 144/315 (45%), Gaps = 20/315 (6%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P + Y IG G+FG V++A+ +G+ VA+KKVL + + RE++I+ Sbjct: 58 PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIM 111 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE---HDLAGLLSNVLVKFTLSEIK 127 + L H N+V L + + + + LV D+ + +A S + +K Sbjct: 112 RKLDHCNIVRLRYFFYSSGEK--KDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVK 169 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYT 186 M L L YIH I HRD+K N+L+ D VLKL DFG A+ + + Sbjct: 170 LYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----V 224 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + + + +YR PEL+ G DY ID+W AGC++AE+ PI G++ QL I ++ G Sbjct: 225 SYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG 284 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + T E ++ K +K ++ P A+ L +LL P R+ Sbjct: 285 TPTREQIREMNPNYTEFKFPQIKAHPWT---KVFRPRTPPEAIALCSRLLEYTPTARLTP 341 Query: 307 DDALNHDFFWSDPMP 321 +A H FF P Sbjct: 342 LEACAHSFFDELRDP 356 >3N9X-A nrPDB Length = 432 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 101/401 (25%), Positives = 172/401 (42%), Gaps = 52/401 (12%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 Y IG+G++G V+ A + T + VA+KKV E LREI IL L Sbjct: 23 HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRL 82 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 K + ++ L ++ +Y+V + + DL L + T IK ++ L Sbjct: 83 KSDYIIRLYDLIIPDD---LLKFDELYIVLEIADSDLKKLFKTPIF-LTEEHIKTILYNL 138 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ------------ 181 L G +IH + I+HRD+K AN L+ +D +K+ DFGLAR + K++ Sbjct: 139 LLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 182 ------PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW-----------T 224 + T+ VVT WYR PEL+L + +Y ID+W GCI AE+ Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTN 258 Query: 225 RSPIMQGN-----------------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL 267 R P+ G+ + + QL +I + G+ T + N++ E+ + ++L Sbjct: 259 RFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKL 318 Query: 268 VKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGM 327 ++ + + K ++L++ +L +P +RI D AL+H + D L+ Sbjct: 319 F-PHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYL-KDVRKKKLENF 376 Query: 328 LSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEF 368 + + F+ + QS +P + F Sbjct: 377 STKKIILPFDDWMVLSETQLRYIFLKEVQSFHPELVIPSVF 417 >4MVF-A nrPDB Length = 506 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 131/306 (42%), Gaps = 52/306 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 KY K+GQGT+G V+K + T Q A+K+ + K +EI+I++ L H Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNI--NRFFQEIEIMKKLDHP 114 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLL 134 N+V L E IYL+ + C L +++ FT +M+ + Sbjct: 115 NIVKLYETYEND--------NYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQIF 164 Query: 135 NGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + ++Y+H I+HRD+K N L +D +LK+ DFGL++ + + T + T Sbjct: 165 SAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT-----TTKAGT 219 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y P++L G+ Y D+W +G IM + P G+T+ L + + Sbjct: 220 PYYVAPQVLDGK--YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYEN 277 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W ++ + A +LI KLL +P +R ++ALN Sbjct: 278 DWGSISS----------------------------DAKNLITKLLTYNPNERCTIEEALN 309 Query: 312 HDFFWS 317 H + Sbjct: 310 HPWITQ 315 >2VN9-A nrPDB Length = 301 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 76/305 (24%), Positives = 126/305 (41%), Gaps = 48/305 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +Y+ ++G+G F V + TGQ+ A K + + RE +I +LLKH Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQML 133 N+V L + +G YLVFD L +++ + ++ ++ +Q + Sbjct: 63 PNIVRLHDSISE--------EGFHYLVFDLVTG--GELFEDIVAREYYSEADASHCIQQI 112 Query: 134 LNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L + + H N I+HRD+K N+L+ ++ +KLADFGLA + + Sbjct: 113 LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLA----IEVQGDQQAWFGFAG 168 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE+L + YG P+D+W G I+ + P + I Sbjct: 169 TPGYLSPEVLRKD-PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 227 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V P A DLI+K+L ++PA+RI + +AL Sbjct: 228 PEWDTV----------------------------TPEAKDLINKMLTINPAKRITASEAL 259 Query: 311 NHDFF 315 H + Sbjct: 260 KHPWI 264 >3UC3-A nrPDB Length = 361 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 82/362 (22%), Positives = 147/362 (40%), Gaps = 50/362 (13%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 ++ P + +Y+ + IG G FG R + T + VA+K + RE Sbjct: 10 PLDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI---ERGAAIDENVQRE 66 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE 125 I + L+H N+V E+ T + ++ ++ +L + N +F+ E Sbjct: 67 IINHRSLRHPNIVRFKEVILTPT--------HLAIIMEYASGGELYERICNA-GRFSEDE 117 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRD--GVLKLADFGLARAFSLAKNSQPN 183 + Q LL+G+ Y H +I HRD+K N L+ LK+ DFG ++ + + Sbjct: 118 ARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK-----SSVLHS 172 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 + + V T Y PE+LL + G D+W G + M + + Sbjct: 173 QPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFE------------- 219 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 PE + + ++ + K + D ++ P LI ++ V DPA R Sbjct: 220 -----DPEEPRD-----YRKTIQRILSVKYSIPDDIR---ISPECCHLISRIFVADPATR 266 Query: 304 IDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATT 363 I + H +F + +P+DL M ++ S F+ P + I Q +++ PA Sbjct: 267 ISIPEIKTHSWFLKN-LPADL--MNESNTGSQFQEPEQPMQSLDTIM-QIISEATIPAVR 322 Query: 364 NQ 365 N+ Sbjct: 323 NR 324 >4E7W-A nrPDB Length = 394 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 88/303 (29%), Positives = 149/303 (49%), Gaps = 21/303 (6%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y IG G+FG VF+A+ ++ + VA+KKVL + + RE++I++++KH NV Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE---HDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 V+L + + + + LV ++ + + + + + IK M LL Sbjct: 95 VDLKAFFYSNGDK--KDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 136 GLYYIHRNKILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 L YIH I HRD+K N+L+ GVLKL DFG A+ + + + + + +Y Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPN-----VSYICSRYY 207 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 R PEL+ G +Y ID+W GC+MAE+ P+ G + QL I ++ G+ + E Sbjct: 208 RAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIK 267 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 ++ + K ++ ++ P A+DLI +LL P+ R+ + +AL H F Sbjct: 268 TMNPNYMEHKFPQIRPHP---FSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPF 324 Query: 315 FWS 317 F Sbjct: 325 FDE 327 >4YZB-A nrPDB Length = 491 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 85/363 (23%), Positives = 160/363 (44%), Gaps = 54/363 (14%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG-FPITALREIKILQLLKH 75 +Y+ +G+G+FGEV + + TGQ+ A+K + K+ L+E+++L+ L H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFD-FCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 N++ L E KG YLV + + +L + + +F+ + R+++ +L Sbjct: 90 PNIMKLYEFFED--------KGYFYLVTEVYTGGELFDEIIS-RKRFSEVDAARIIRQVL 140 Query: 135 NGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +G+ Y+H+NKI+HRD+K N+L+ +D +++ DFGL+ F K + +++ T Sbjct: 141 SGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTK-----KMKDKIGT 195 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 +Y PE+L G Y D+W G I+ + + P G E L + + + Sbjct: 196 AYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLP 253 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V A DLI K+L P RI + DAL Sbjct: 254 QWKKV----------------------------SEPAKDLIRKMLAYVPTMRISARDALE 285 Query: 312 HDFFWSDPMPSD--LKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFE 369 H++ + +D L + + ++ ++ + + + + + N T E Sbjct: 286 HEWLKTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEET---VELN 342 Query: 370 RVF 372 ++F Sbjct: 343 KIF 345 >3E3P-A nrPDB Length = 360 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 96/348 (27%), Positives = 149/348 (42%), Gaps = 32/348 (9%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ--- 71 E+ +++ GQGTFG V + + TG VA+KKV+ + RE++I+Q Sbjct: 21 EMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN------RELQIMQDLA 74 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF---TLSEIKR 128 +L H N+V L T +R + +V ++ L N + IK Sbjct: 75 VLHHPNIVQLQSYFYTLGER-DRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKV 133 Query: 129 VMQMLLNGLYYIH--RNKILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRY 185 + L+ + +H + HRD+K NVL+ DG LKL DFG A+ S ++ + Sbjct: 134 FLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPN----- 188 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 + + +YR PEL+ G + Y +D+W GCI AEM PI +G+ QL I ++ Sbjct: 189 VAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVL 248 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 G + EV ++ L KG + A DL+ LL P +R+ Sbjct: 249 GCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMK 308 Query: 306 SDDALNHDFF--WSDP---------MPSDLKGMLSTHLTSMFEYLAPP 342 +AL H +F DP +P DL L + M E Sbjct: 309 PYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAK 356 >5U6Y-A nrPDB Length = 461 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 124/304 (40%), Gaps = 48/304 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ ++G+G F V + GQ+ A K + + RE +I +LLKH N+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 V L + +G YL+FD L +++ + ++ ++ +Q +L Sbjct: 62 VRLHDSISE--------EGHHYLIFDLVTG--GELFEDIVAREYYSEADASHCIQQILEA 111 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + + H+ ++HRD+K N+L+ + +KLADFGLA + + + T Sbjct: 112 VLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----IEVEGEQQAWFGFAGTPG 167 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L + YG P+DLW G I+ + P + I W Sbjct: 168 YLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 226 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 V P A DLI+K+L ++P++RI + +AL H Sbjct: 227 DTV----------------------------TPEAKDLINKMLTINPSKRITAAEALKHP 258 Query: 314 FFWS 317 + Sbjct: 259 WISH 262 >3NIE-A nrPDB Length = 429 Score = 261 bits (667), Expect = 4e-70, Method: Composition-based stats. Identities = 92/350 (26%), Positives = 152/350 (43%), Gaps = 54/350 (15%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 YE IG+G++G V+ A + + VA+KKV E LREI IL LK + Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 ++ L ++ + +Y+V + + DL L + T +K ++ LL G Sbjct: 88 YIIRLHDLIIPED---LLKFDELYIVLEIADSDLKKLFKTPIF-LTEQHVKTILYNLLLG 143 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ--------------- 181 +IH + I+HRD+K AN L+ +D +K+ DFGLAR + K+ Sbjct: 144 EKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPG 203 Query: 182 ------PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW-----------T 224 + T+ VVT WYR PEL+L + +Y ID+W GCI AE+ Sbjct: 204 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTN 263 Query: 225 RSPIMQGN-----------------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL 267 R P+ G+ + + QL +I + G+ E + E+ + ++L Sbjct: 264 RFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKL 323 Query: 268 VKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 + + K +DL++ +L + +RI D AL+H + Sbjct: 324 F-PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD 372 >2VZ6-A nrPDB Length = 313 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 124/304 (40%), Gaps = 48/304 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ ++G+G F V + GQ+ A K + + RE +I +LLKH N+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 V L + +G YL+FD L +++ + ++ ++ +Q +L Sbjct: 84 VRLHDSISE--------EGHHYLIFDLVTG--GELFEDIVAREYYSEADASHCIQQILEA 133 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + + H+ ++HRD+K N+L+ + +KLADFGLA + + + T Sbjct: 134 VLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLA----IEVEGEQQAWFGFAGTPG 189 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L + YG P+DLW G I+ + P + I W Sbjct: 190 YLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 248 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 V P A DLI+K+L ++P++RI + +AL H Sbjct: 249 DTV----------------------------TPEAKDLINKMLTINPSKRITAAEALKHP 280 Query: 314 FFWS 317 + Sbjct: 281 WISH 284 >5FG8-A nrPDB Length = 285 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 122/304 (40%), Gaps = 48/304 (15%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Y+ ++G+G F V + + TG + A K + + RE +I + L H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLL 134 N+V L + + + YLVFD L +++ + ++ ++ +Q +L Sbjct: 74 NIVRLHDSIQE--------ENYHYLVFDLVTG--GELFEDIVAREFYSEADASHCIQQIL 123 Query: 135 NGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + + H+N ++HRD+K N+L+ + +KLADFGLA + + T Sbjct: 124 ESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLA----IEVQGDHQAWFGFAGT 179 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PE+L + YG +D+W G I+ + P + + I Sbjct: 180 PGYLSPEVL-KKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSP 238 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V P A +LI+++L ++P +RI + +AL Sbjct: 239 EWDTV----------------------------TPEAKNLINQMLTVNPNKRITAAEALK 270 Query: 312 HDFF 315 H + Sbjct: 271 HPWI 274 >3MN3-A nrPDB Length = 271 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 78/313 (24%), Positives = 136/313 (43%), Gaps = 48/313 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALREIKILQLLK 74 + Y+ + +G+G+FG+V A H TGQKVALK + + K REI L+LL+ Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLR 62 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H +++ L ++ ++ K I +V ++ ++L + K + E +R Q ++ Sbjct: 63 HPHIIKLYDVIKS--------KDEIIMVIEYAGNELFDYIVQ-RDKMSEQEARRFFQQII 113 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 + + Y HR+KI+HRD+K N+L+ +K+ADFGL+ + N + Y Sbjct: 114 SAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDG-----NFLKTSCGSPNY 168 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ G+ GP +D+W G I+ M R + IS ++ Sbjct: 169 AAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPK---- 224 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 P A LI ++L+++P RI + + D+ Sbjct: 225 ----------------------------FLSPGAAGLIKRMLIVNPLNRISIHEIMQDDW 256 Query: 315 FWSDPMPSDLKGM 327 F D +P L Sbjct: 257 FKVD-LPEYLLPP 268 >2I6L-A nrPDB Length = 320 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 103/317 (32%), Positives = 152/317 (47%), Gaps = 14/317 (4%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S+Y L +G G G VF A ++VA+KK+++ + + ALREIKI++ L Sbjct: 8 DLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS--VKHALREIKIIRRL 65 Query: 74 KHENVVNLIEICRTKASPYNRCKGSI------YLVFDFCEHDLAGLLSNVLVKFTLSEIK 127 H+N+V + EI S GS+ Y+V ++ E DLA +L + Sbjct: 66 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQ--GPLLEEHAR 123 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYT 186 M LL GL YIH +LHRD+K AN+ I D VLK+ DFGLAR S + Sbjct: 124 LFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP-HYSHKGHLS 182 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 +VT WYR P LLL +Y ID+W AGCI AEM T + G E Q+ LI + Sbjct: 183 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 242 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + E + + + + + L R A+D ++++L P R+ + Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISR--EAVDFLEQILTFSPMDRLTA 300 Query: 307 DDALNHDFFWSDPMPSD 323 ++AL+H + P D Sbjct: 301 EEALSHPYMSIYSFPMD 317 >2V7O-A nrPDB Length = 336 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 76/348 (21%), Positives = 140/348 (40%), Gaps = 49/348 (14%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 Y+ ++G+G F V + + Q+ A K + + RE +I +LLKH Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKH 89 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQML 133 N+V L + +G YLVFD L +++ + ++ ++ + + Sbjct: 90 PNIVRLHDSISE--------EGFHYLVFDLVTG--GELFEDIVAREYYSEADASHCIHQI 139 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGV---LKLADFGLARAFSLAKNSQPNRYTNRVV 190 L + +IH++ I+HRD+K N+L+ +KLADFGLA + + + Sbjct: 140 LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLA----IEVQGEQQAWFGFAG 195 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE+L + YG P+D+W G I+ + P + I Sbjct: 196 TPGYLSPEVLRKD-PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 254 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V P A +LI+++L ++PA+RI +D AL Sbjct: 255 PEWDTV----------------------------TPEAKNLINQMLTINPAKRITADQAL 286 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSR 358 H + + + + + ++ A + KG+ +T +++ Sbjct: 287 KHPWVCQRSTVASMMHR-QETVECLRKFNARRKLKGAILTTMLVSRNF 333 >3ZUT-A nrPDB Length = 362 Score = 257 bits (657), Expect = 5e-69, Method: Composition-based stats. Identities = 81/362 (22%), Positives = 147/362 (40%), Gaps = 50/362 (13%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 ++ P + +YE + IG G FG R +++ + VA+K + E RE Sbjct: 9 PMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI---ERGEKIDENVKRE 65 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE 125 I + L+H N+V E+ T + +V ++ +L + N +F+ E Sbjct: 66 IINHRSLRHPNIVRFKEVILTPT--------HLAIVMEYASGGELFERICNA-GRFSEDE 116 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPN 183 + Q L++G+ Y H ++ HRD+K N L+ LK+ FG ++ + + Sbjct: 117 ARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK-----SSVLHS 171 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 + + V T Y PE+LL + G D+W G + M + + Sbjct: 172 QPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE------------- 218 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 PE N + + + + + D + P LI ++ V DPA+R Sbjct: 219 -----DPEEPKNFR-----KTIHRILNVQYAIPDYVH---ISPECRHLISRIFVADPAKR 265 Query: 304 IDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATT 363 I + NH++F + +P+DL M +T+ F+ P + +I Q ++ P Sbjct: 266 ISIPEIRNHEWFLKN-LPADL--MNDNTMTTQFDESDQPGQSIEEIM-QIIAEATVPPAG 321 Query: 364 NQ 365 Q Sbjct: 322 TQ 323 >2BDW-A nrPDB Length = 362 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 123/304 (40%), Gaps = 49/304 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Y+ ++G+G F V + H+ TG + A K + + RE +I + L+H Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLL 134 N+V L + + ++ YLVFD L +++ + ++ ++ +Q +L Sbjct: 89 NIVRLHDSIQEESFH--------YLVFDLVTG--GELFEDIVAREFYSEADASHCIQQIL 138 Query: 135 NGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + Y H N I+HR++K N+L+ + +KLADFGLA + ++ + T Sbjct: 139 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSE-----AWHGFAGT 193 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PE+L + Y P+D+W G I+ + P + A I Sbjct: 194 PGYLSPEVLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSP 252 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V P A LID +L ++P +RI +D AL Sbjct: 253 EWDTV----------------------------TPEAKSLIDSMLTVNPKKRITADQALK 284 Query: 312 HDFF 315 + Sbjct: 285 VPWI 288 >5Y86-A nrPDB Length = 588 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 93/348 (26%), Positives = 154/348 (44%), Gaps = 55/348 (15%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 + P +YE L IG+G+FG+V + K Q VALK V E F A Sbjct: 194 DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK---RFHRQA 250 Query: 64 LREIKILQLLKHE------NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-N 116 EI+IL+ LK + NV++++E + + + F+ DL L+ N Sbjct: 251 AEEIRILEHLKKQDKTGSMNVIHMLESFT--------FRNHVCMAFELLSIDLYELIKKN 302 Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAF 174 F++ +++ Q +L L +H+NKI+H D+K N+L+ G K+ DFG + Sbjct: 303 KFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSS--- 359 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 + + + + +YR PE++LG R Y PID+W GCI+AE+ T P+ G E Sbjct: 360 ----CFEYQKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDE 414 Query: 235 QHQLALISQLCGSITPEVWPNVDNYELY-----------------EKLELVKGQKRKVKD 277 QLA + +L G P++ + + ++ LV G+ R+ K Sbjct: 415 GDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474 Query: 278 RLKAYVR----------DPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 R + D ++ + + L DP+ R+ AL H + Sbjct: 475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWI 522 >3SOA-A nrPDB Length = 444 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 124/307 (40%), Gaps = 48/307 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +Y+ ++G+G F V + GQ+ A + + RE +I +LLKH Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKH 69 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQML 133 N+V L + +G YL+FD L +++ + ++ ++ +Q + Sbjct: 70 PNIVRLHDSISE--------EGHHYLIFDLVTG--GELFEDIVAREYYSEADASHCIQQI 119 Query: 134 LNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L + + H+ ++HR++K N+L+ + +KLADFGLA + + + Sbjct: 120 LEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLA----IEVEGEQQAWFGFAG 175 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE+L + YG P+DLW G I+ + P + I Sbjct: 176 TPGYLSPEVLRKD-PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 234 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V P A DLI+K+L ++P++RI + +AL Sbjct: 235 PEWDTV----------------------------TPEAKDLINKMLTINPSKRITAAEAL 266 Query: 311 NHDFFWS 317 H + Sbjct: 267 KHPWISH 273 >3BHH-A nrPDB Length = 295 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 122/304 (40%), Gaps = 48/304 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +Y+ IG+G F V + TG + A K + + RE +I +LLKH Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQML 133 N+V L + +G YLVFD L +++ + ++ ++ +Q + Sbjct: 63 SNIVRLHDSISE--------EGFHYLVFDLVTG--GELFEDIVAREYYSEADASHCIQQI 112 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGV---LKLADFGLARAFSLAKNSQPNRYTNRVV 190 L + + H+ ++HRD+K N+L+ +KLADFGLA + + Sbjct: 113 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLA----IEVQGDQQAWFGFAG 168 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE+L E YG P+D+W G I+ + P + I Sbjct: 169 TPGYLSPEVLRKE-AYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPS 227 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 W V P A +LI+++L ++PA+RI + +AL Sbjct: 228 PEWDTV----------------------------TPEAKNLINQMLTINPAKRITAHEAL 259 Query: 311 NHDF 314 H + Sbjct: 260 KHPW 263 >5ES1-A nrPDB Length = 328 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 55/356 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 V Y L IG+G F +V ARH TG++VA+K + RE++I++ L Sbjct: 12 PHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGL 71 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTLSEIKRVM 130 H N+V L E+ T+ + +YLV ++ AG + + LV + E + Sbjct: 72 NHPNIVKLFEVIETEKT--------LYLVMEYAS---AGEVFDYLVSHGRMKEKEARAKF 120 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + +++ ++Y H+ I+HRD+KA N+L+ + +K+ADFG + F+L + Sbjct: 121 RQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGS-----KLDTFCG 175 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PEL G++ GP +D+W G I+ + + S G+ + + + + Sbjct: 176 SPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF 235 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + + ++ + + LVL+PA+R + + Sbjct: 236 YMSTDCESI--------------------------------LRRFLVLNPAKRCTLEQIM 263 Query: 311 NHDFFWSDPMPSDLKGMLSTHL----TSMFEYLAPPRRKGSQITQQSTNQSRNPAT 362 + +LK T E + +I + T+Q N T Sbjct: 264 KDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVT 319 >3KK8-A nrPDB Length = 284 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 123/304 (40%), Gaps = 49/304 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 Y+ ++G+G F V + H+ TG + A K + + RE +I + L+H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLL 134 N+V L + + ++ YLVFD L +++ + ++ ++ +Q +L Sbjct: 66 NIVRLHDSIQEESFH--------YLVFDLVTG--GELFEDIVAREFYSEADASHCIQQIL 115 Query: 135 NGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + Y H N I+HR++K N+L+ + +KLADFGLA + ++ + T Sbjct: 116 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSE-----AWHGFAGT 170 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PE+L + Y P+D+W G I+ + P + A I Sbjct: 171 PGYLSPEVLKKD-PYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSP 229 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 W V P A LID +L ++P +RI +D AL Sbjct: 230 EWDTV----------------------------TPEAKSLIDSMLTVNPKKRITADQALK 261 Query: 312 HDFF 315 + Sbjct: 262 VPWI 265 >2QNJ-A nrPDB Length = 328 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 134/326 (41%), Gaps = 45/326 (13%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 ++ + Y L IG+G F +V ARH TG++VA+K + RE Sbjct: 2 AMGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFRE 61 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI 126 ++I+++L H N+V L E+ T+ + +YL+ ++ + E Sbjct: 62 VRIMKILNHPNIVKLFEVIETEKT--------LYLIMEYASGGEVFDYLVAHGRMKEKEA 113 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + + +++ + Y H+ +I+HRD+KA N+L+ D +K+ADFG + F++ + Sbjct: 114 RSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVG-----GKLD 168 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + Y PEL G++ GP +D+W G I+ + + S G + + + Sbjct: 169 TFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY 228 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 I + + +N L+ + LVL+P +R Sbjct: 229 RIPFYMSTDCEN--------------------------------LLKRFLVLNPIKRGTL 256 Query: 307 DDALNHDFFWSDPMPSDLKGMLSTHL 332 + + + + +LK + L Sbjct: 257 EQIMKDRWINAGHEEDELKPFVEPEL 282 >4RGJ-A nrPDB Length = 520 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 79/360 (21%), Positives = 159/360 (44%), Gaps = 53/360 (14%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG-FPITALREIKILQLLKH 75 +Y+ + +G+G+FGEV +R + TG + A+K + ++ K + LRE+++L++L H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFD-FCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 N++ L E YLV D + +L + + +F + R+++ +L Sbjct: 120 INIMKLYEFFEDN--------NYYYLVSDVYTGGELFDEIIS-RKRFYEIDAARIIKQIL 170 Query: 135 NGLYYIHRNKILHRDMKAANVLI----TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H+N ++HRD+K N+L+ D ++K+ DFGL+ F +K + +++ Sbjct: 171 SGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSK-----KMKDKIG 225 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y P++L G Y D+W G I+ + + P G+ E L + + Sbjct: 226 TAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDL 283 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + + + A DLI K+L+ A RI + DAL Sbjct: 284 PQFKKISD----------------------------KAKDLIKKMLMYTSAVRISARDAL 315 Query: 311 NHDFFWSDPMPSDLK---GMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTE 367 H++ +L L + ++ ++ + + + + + + T T+ Sbjct: 316 EHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQAALLYMGSKLTTIDETKELTK 375 >5YKS-A nrPDB Length = 377 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 130/323 (40%), Gaps = 48/323 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ +G+G F V ARH TG+KVA+K + +E++ ++L++H N+ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V L E+ T+ +YL+ + + D+ + K+ +++ + Sbjct: 97 VRLYEVIDTQT--------KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAI 148 Query: 138 YYIHRNKILHRDMKAANV-LITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Y H+ ++HRD+K NV + G++KL DFG + F K + T +L Y Sbjct: 149 SYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK-----KLTTSCGSLAYSA 203 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 PE+LLG+ P +D+W G I+ + P Q + L +I ++ V Sbjct: 204 PEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHV---- 259 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 DLI ++L DP +R ++ NH + Sbjct: 260 ----------------------------SKECKDLITRMLQRDPKRRASLEEIENHPWLQ 291 Query: 317 S-DPMPSDLKGMLSTHLTSMFEY 338 DP P+ + ++ E Sbjct: 292 GVDPSPATKYNIPLVSYKNLSEE 314 >3UDB-A nrPDB Length = 317 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 83/348 (23%), Positives = 144/348 (41%), Gaps = 49/348 (14%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 ++ P + +YE + IG G FG R ++ + VA+K + E RE Sbjct: 9 PMDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI---ERGEKIDENVKRE 65 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE 125 I + L+H N+V E+ T + +V ++ +L + N +F+ E Sbjct: 66 IINHRSLRHPNIVRFKEVILTPT--------HLAIVMEYASGGELFERICNA-GRFSEDE 116 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--VLKLADFGLARAFSLAKNSQPN 183 + Q L++G+ Y H ++ HRD+K N L+ LK+ADFG ++A L + Sbjct: 117 ARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPK-- 174 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 + V T Y PE+LL + G D+W G + M + + Sbjct: 175 ---SAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFE------------- 218 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 PE N + + + + + D + P LI ++ V DPA+R Sbjct: 219 -----DPEEPKNFR-----KTIHRILNVQYAIPDYVH---ISPECRHLISRIFVADPAKR 265 Query: 304 IDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQ 351 I + NH++F + +P+DL M +T+ F+ P + +I Q Sbjct: 266 ISIPEIRNHEWFLKN-LPADL--MNDNTMTTQFDESDQPGQSIEEIMQ 310 >5ZTN-A nrPDB Length = 429 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 100/350 (28%), Positives = 159/350 (45%), Gaps = 55/350 (15%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Q V+ P +YE L IG+G+FG+V KA K Q VALK V E F A Sbjct: 84 QGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEK---RFHRQA 140 Query: 64 LREIKILQLLKHE------NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SN 116 EI+IL+ L+ + NV++++E + I + F+ +L L+ N Sbjct: 141 AEEIRILEHLRKQDKDNTMNVIHMLENFT--------FRNHICMTFELLSMNLYELIKKN 192 Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV--LKLADFGLARAF 174 F+L +++ +L L +H+N+I+H D+K N+L+ + G +K+ DFG + Sbjct: 193 KFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--- 249 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 + R + + +YR PE++LG R YG PID+W GCI+AE+ T P++ G E Sbjct: 250 ----CYEHQRVYTYIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDE 304 Query: 235 QHQLALISQLCGSITPEVWPNVDNYELYE-----------------KLELVKGQKRKVKD 277 QLA + +L G + ++ + + + L G+ R+ K Sbjct: 305 GDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL 364 Query: 278 RLKAYVR----------DPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 R R DP LD + + L DPA R+ AL H + Sbjct: 365 RGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRR 414 >5IG1-A nrPDB Length = 344 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 69/322 (21%), Positives = 122/322 (37%), Gaps = 55/322 (17%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL 64 +D + D+ S IG+G F V + +++TG+ A+K + +++ + Sbjct: 11 FDLYDVDLKDKRS------VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIK 64 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FT 122 REI I L+HE++V++ R ++ YLVF++ L ++ + + Sbjct: 65 REIGICSSLQHEHIVSMRRAFRDES--------HFYLVFEYVSG--GELFDEIVTRKFYN 114 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKN 179 + M +L+ L + H I+HRD+K N+L+ + +K+ DFGLA Sbjct: 115 EKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIME---- 170 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 Q Y T Y PE++ Y +D+W G I+ + P Q A Sbjct: 171 -QGPTYFGFAGTPGYLSPEVIR-RVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYA 228 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 I W +V A +LI +L + Sbjct: 229 QIKNCQYDFPSPEWDSVTTA----------------------------AKELIKAMLEPN 260 Query: 300 PAQRIDSDDALNHDFFWSDPMP 321 P +R + L H + +P Sbjct: 261 PKRRPTVQELLQHPWIARRDVP 282 >3EB0-A nrPDB Length = 383 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 84/366 (22%), Positives = 157/366 (42%), Gaps = 54/366 (14%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 KY +G G+FG V + ++G++ ALKKVL + + RE+ I+++L H N Sbjct: 8 KYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN------RELDIMKVLDHVN 61 Query: 78 VVNLIEICRTKASPYNRCKGS------------------------------IYLVFDFCE 107 ++ L++ T + + ++ ++ Sbjct: 62 IIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVP 121 Query: 108 HDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL 163 L +L + + ++ I + L + +IH I HRD+K N+L+ +D L Sbjct: 122 DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTL 181 Query: 164 KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW 223 KL DFG A+ ++ S + + +YR PEL+LG +Y P IDLW GC+ E+ Sbjct: 182 KLCDFGSAKKLIPSEPS-----VAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI 236 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 P+ G T QL I Q+ G+ T E ++ + + +K + + ++ Sbjct: 237 LGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWR---KILPEG 293 Query: 284 RDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPR 343 A+DL++++L +P RI+ +A+ H FF L+ + + + + Sbjct: 294 TPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDH------LRNSYESEVKNNSNFPHGVN 347 Query: 344 RKGSQI 349 + Q+ Sbjct: 348 QNIPQL 353 >5KCV-A nrPDB Length = 460 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 77/357 (21%), Positives = 140/357 (39%), Gaps = 65/357 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLK 74 ++++E L +G+GTFG+V + + TG+ A+K + E + L E ++LQ + Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H + L +T + V ++ + F+ + ++ Sbjct: 221 HPFLTALKYSFQT--------HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 272 Query: 135 NGLYYIHR-NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + L Y+H +++RD+K N+++ +DG +K+ DFGL + T Sbjct: 273 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE----GIKDGATMKTFCGTPE 328 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L + DYG +D WG G +M EM + LI Sbjct: 329 YLAPEVL-EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI------------ 375 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDD 308 L E++ + P A L+ LL DP QR+ D+ + Sbjct: 376 -------LMEEIRFPR-------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKE 415 Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365 + H FF G++ H+ + L+PP + Q+T ++ + + T Q Sbjct: 416 IMQHRFF---------AGIVWQHVYE--KKLSPPFK--PQVTSETDTRYFDEEFTAQ 459 >5KZ7-A nrPDB Length = 346 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 130/317 (41%), Gaps = 45/317 (14%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 + Y L IG+G F +V ARH TG++VA+K + RE++I+++L Sbjct: 30 PHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVL 89 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H N+V L E+ T+ + +YLV ++ + E + + + Sbjct: 90 NHPNIVKLFEVIETEKT--------LYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 141 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ + Y H+ I+HRD+KA N+L+ D +K+ADFG + F+ N+ + Sbjct: 142 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG-----NKLDTFCGSPP 196 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PEL G++ GP +D+W G I+ + + S G + + + I + Sbjct: 197 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 256 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + +N L+ K L+L+P++R + + Sbjct: 257 TDCEN--------------------------------LLKKFLILNPSKRGTLEQIMKDR 284 Query: 314 FFWSDPMPSDLKGMLST 330 + +LK + Sbjct: 285 WMNVGHEDDELKPYVEP 301 >3Q5I-A nrPDB Length = 504 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 77/350 (22%), Positives = 144/350 (41%), Gaps = 63/350 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-----------ENEKEGFPITALREI 67 Y K+ K+G G +GEV + + + A+K + E F EI Sbjct: 38 YFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEI 97 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSE 125 +L+ L H N++ L ++ K YLV +F E L ++ KF + Sbjct: 98 SLLKSLDHPNIIKLFDVFEDKK--------YFYLVTEFYEG--GELFEQIINRHKFDECD 147 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQP 182 +M+ +L+G+ Y+H++ I+HRD+K N+L+ +K+ DFGL+ FS + Sbjct: 148 AANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFS-----KD 202 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + +R+ T +Y PE+L ++ Y D+W G IM + P G +Q + + Sbjct: 203 YKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVE 260 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + W N+ + A +LI +L D + Sbjct: 261 KGKYYFDFNDWKNISD----------------------------EAKELIKLMLTYDYNK 292 Query: 303 RIDSDDALNHDFF--WSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQIT 350 R +++ALN + +++ + + L L++M ++ + + I Sbjct: 293 RCTAEEALNSRWIKKYANNINKSDQKTLCGALSNMRKFEGSQKLAQAAIL 342 >2YCR-A nrPDB Length = 323 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 86/348 (24%), Positives = 138/348 (39%), Gaps = 60/348 (17%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-----EKEGFP-ITALREIKIL 70 +Y +G G GEV A RKT +KVA+K + +E P + EI+IL Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKR 128 + L H ++ + + Y+V + E L V+ + + K Sbjct: 70 KKLNHPCIIKIKNFFDAE---------DYYIVLELMEG--GELFDKVVGNKRLKEATCKL 118 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRY 185 +L + Y+H N I+HRD+K NVL++ D ++K+ DFG ++ + + Sbjct: 119 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-----GETSLM 173 Query: 186 TNRVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA-LIS 242 T Y PE+L+ G Y +D W G I+ + P + Q L I+ Sbjct: 174 RTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT 233 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + PEVW V ALDL+ KLLV+DP Sbjct: 234 SGKYNFIPEVWAEV----------------------------SEKALDLVKKLLVVDPKA 265 Query: 303 RIDSDDALNHDFFWSDPMPSDLKGMLS--THLTSMFEYLAPPRRKGSQ 348 R +++AL H + + M + +LS T+ + LA P + Sbjct: 266 RFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRKR 313 >3MV5-A nrPDB Length = 342 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 77/357 (21%), Positives = 140/357 (39%), Gaps = 65/357 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLK 74 ++++E L +G+GTFG+V + + TG+ A+K + E + L E ++LQ + Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H + L +T + V ++ + F+ + ++ Sbjct: 69 HPFLTALKYSFQT--------HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV 120 Query: 135 NGLYYIHR-NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + L Y+H +++RD+K N+++ +DG +K+ DFGL + T Sbjct: 121 SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE----GIKDGATMKTFCGTPE 176 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L + DYG +D WG G +M EM + LI Sbjct: 177 YLAPEVL-EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI------------ 223 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDD 308 L E++ + P A L+ LL DP QR+ D+ + Sbjct: 224 -------LMEEIRFPR-------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKE 263 Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365 + H FF G++ H+ + L+PP + Q+T ++ + + T Q Sbjct: 264 IMQHRFF---------AGIVWQHVYE--KKLSPPFK--PQVTSETDTRYFDEEFTAQ 307 >3H4J-B nrPDB Length = 336 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 80/313 (25%), Positives = 135/313 (43%), Gaps = 48/313 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLK 74 + Y +G+G+FG+V A H KT QKVALK + + +K + REI L+LL+ Sbjct: 8 IGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLR 67 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H +++ L ++ T I +V ++ +L + + T E +R Q ++ Sbjct: 68 HPHIIKLYDVITTPTD--------IVMVIEYAGGELFDYIVEK-KRMTEDEGRRFFQQII 118 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 + Y HR+KI+HRD+K N+L+ + +K+ADFGL+ + N + Y Sbjct: 119 CAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDG-----NFLKTSCGSPNY 173 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ G+ GP +D+W G ++ M E P Sbjct: 174 AAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPF-------------------DDEFIP 214 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 N L++K+ P A LI +++V DP QRI + + Sbjct: 215 N-----LFKKVNSCVYVMPDF--------LSPGAQSLIRRMIVADPMQRITIQEIRRDPW 261 Query: 315 FWSDPMPSDLKGM 327 F + +P L+ M Sbjct: 262 FNVN-LPDYLRPM 273 >6FD3-A nrPDB Length = 300 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 73/317 (23%), Positives = 136/317 (42%), Gaps = 49/317 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D KY + KIGQG G V+ A TGQ+VA+K++ ++ + + + EI +++ Sbjct: 19 DPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK--ELIINEILVMREN 76 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQ 131 K+ N+VN ++ +++V ++ G L++V+ + + E I V + Sbjct: 77 KNPNIVNYLDSY--------LVGDELWVVMEYL---AGGSLTDVVTETCMDEGQIAAVCR 125 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L L ++H N+++HRD+K+ N+L+ DG +KL DFG + + ++ + V T Sbjct: 126 ECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP----EQSKRSTMVGT 181 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PE++ + YGP +D+W G + EM P L LI+ Sbjct: 182 PYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA--------- 231 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + D +++ L +D +R + + L Sbjct: 232 --------------------TNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ 271 Query: 312 HDFFWSDPMPSDLKGML 328 H F D S L ++ Sbjct: 272 HPFLKLDKPLSSLTPLI 288 >4REW-A nrPDB Length = 540 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 137/330 (41%), Gaps = 53/330 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 ++ Y +G GTFG+V +H TG KVA+K + + + + REI+ L+L Sbjct: 4 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 63 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIKRVM 130 +H +++ L ++ T + I++V ++ G L + + + E +R+ Sbjct: 64 RHPHIIKLYQVISTPSD--------IFMVMEYVS---GGELFDYICKNGRLDEKESRRLF 112 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q +L+G+ Y HR+ ++HRD+K NVL+ K+ADFGL+ S + Sbjct: 113 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----LRTSCG 167 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ G GP +D+W +G I+ + + + I Sbjct: 168 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ 227 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + +P + L+ +L +DP +R D Sbjct: 228 YL--------------------------------NPSVISLLKHMLQVDPMKRASIKDIR 255 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLA 340 H++F D +P L ++ ++M + A Sbjct: 256 EHEWFKQD-LPKYLFPEDPSYSSTMIDDEA 284 >4FG9-A nrPDB Length = 320 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 119/310 (38%), Gaps = 50/310 (16%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D Y+ +G G F EV A ++T + VA+K + E EG + EI +L + Sbjct: 15 DIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL-EGKEGSMENEIAVLHKI 73 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQ 131 KH N+V L +I + G +YL+ L ++ K +T + R++ Sbjct: 74 KHPNIVALDDIYESG--------GHLYLIMQLVSG--GELFDRIVEKGFYTERDASRLIF 123 Query: 132 MLLNGLYYIHRNKILHRDMKAANVL---ITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 +L+ + Y+H I+HRD+K N+L + D + ++DFGL++ + Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSV-----LSTA 178 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 T Y PE+L ++ Y +D W G I + P + I + Sbjct: 179 CGTPGYVAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEF 237 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 W ++ + A D I L+ DP +R + Sbjct: 238 DSPYWDDISDS----------------------------AKDFIRHLMEKDPEKRFTCEQ 269 Query: 309 ALNHDFFWSD 318 AL H + D Sbjct: 270 ALQHPWIAGD 279 >3COM-A nrPDB Length = 314 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 135/328 (41%), Gaps = 47/328 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++ L K+G+G++G V+KA H++TGQ VA+K+V E ++EI I+Q +V Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV----PVESDLQEIIKEISIMQQCDSPHV 86 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V +++V ++C ++ ++ T EI ++Q L GL Sbjct: 87 VKYYGSYFKNTD--------LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGL 138 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+H + +HRD+KA N+L+ +G KLADFG+A + + + T ++ P Sbjct: 139 EYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT----DTMAKRNTVIGTPFWMAP 194 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E++ E Y D+W G EM P + H + I + + P Sbjct: 195 EVI-QEIGYNCVADIWSLGITAIEMAEGKPPY---ADIHPMRAIFMIPTNPPPTF----- 245 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 K + D + + LV P QR + L H F S Sbjct: 246 ---------------------RKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRS 284 Query: 318 DPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 S L+ +++ + + +R+ Sbjct: 285 AKGVSILRDLINEAMDVKLKRQESQQRE 312 >2JC6-A nrPDB Length = 334 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 123/318 (38%), Gaps = 50/318 (15%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 S + D +E +G G F EV A + TG+ A+K + + K G + Sbjct: 11 SSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK-GKESSIEN 69 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTL 123 EI +L+ +KHEN+V L +I + +YLV L ++ K +T Sbjct: 70 EIAVLRKIKHENIVALEDIYESP--------NHLYLVMQLVSG--GELFDRIVEKGFYTE 119 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNS 180 + +++ +L+ +YY+HR I+HRD+K N+L + + ++DFGL++ Sbjct: 120 KDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-----EG 174 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 + + + T Y PE+L ++ Y +D W G I + P + Sbjct: 175 KGDVMSTACGTPGYVAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQ 233 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 I + W ++ + A D I L+ DP Sbjct: 234 ILKAEYEFDSPYWDDISDS----------------------------AKDFIRNLMEKDP 265 Query: 301 AQRIDSDDALNHDFFWSD 318 +R + A H + D Sbjct: 266 NKRYTCEQAARHPWIAGD 283 >4RED-A nrPDB Length = 351 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 136/330 (41%), Gaps = 53/330 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 ++ Y +G GTFG+V +H TG VA+K + + + + REI+ L+L Sbjct: 12 KIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLF 71 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIKRVM 130 +H +++ L ++ T + I++V ++ G L + + + E +R+ Sbjct: 72 RHPHIIKLYQVISTPSD--------IFMVMEYVS---GGELFDYICKNGRLDEKESRRLF 120 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q +L+G+ Y HR+ ++HRD+K NVL+ K+ADFGL+ S + Sbjct: 121 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----LRTSCG 175 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ G GP +D+W +G I+ + + + I Sbjct: 176 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ 235 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + +P + L+ +L +DP +R D Sbjct: 236 YL--------------------------------NPSVISLLKHMLQVDPMKRASIKDIR 263 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLA 340 H++F D +P L ++ T+M + A Sbjct: 264 EHEWFKQD-LPKYLFPEDPSYSTTMIDDEA 292 >3UTO-A nrPDB Length = 573 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 74/351 (21%), Positives = 131/351 (37%), Gaps = 49/351 (13%) Query: 3 KQY--DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 KQY VE + Y+ ++G G FG V + R TG A K V+ +E + Sbjct: 141 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK-- 198 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV 119 T +EI+ + +L+H +VNL + + ++++F +L +++ Sbjct: 199 ETVRKEIQTMSVLRHPTLVNLHDAFEDD--------NEMVMIYEFMSGGELFEKVADEHN 250 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLA 177 K + E M+ + GL ++H N +H D+K N++ T R LKL DFGL Sbjct: 251 KMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPK 310 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 ++ + T + PE+ G + G D+W G + + + G + Sbjct: 311 QSVKVTT-----GTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDET 364 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 L + K + D + + D I KLL+ Sbjct: 365 LRNV---------------------------KSCDWNMDDSAFSGI-SEDGKDFIRKLLL 396 Query: 298 LDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQ 348 DP R+ AL H + P + S+ T + + + + Sbjct: 397 ADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 447 >2JDO-A nrPDB Length = 342 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 78/358 (21%), Positives = 138/358 (38%), Gaps = 66/358 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALREIKILQLLK 74 ++ ++ L +G+GTFG+V R + TG+ A+K + E + + E ++LQ + Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H + L +T + V ++ + FT + ++ Sbjct: 69 HPFLTALKYAFQT--------HDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 120 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 + L Y+H +++RD+K N+++ +DG +K+ DFGL + S T Y Sbjct: 121 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE----GISDGATMKTFCGTPEY 176 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE+L + DYG +D WG G +M EM + LI Sbjct: 177 LAPEVL-EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI------------- 222 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDA 309 L E++ + P A L+ LL DP QR+ D+ + Sbjct: 223 ------LMEEIRFPR-------------TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEV 263 Query: 310 LNHDFFWSDPMPSDLKGMLSTHLTSMFE-YLAPPRRKGSQITQQSTNQSRNPATTNQT 366 + H FF LS + + + L PP + Q+T + + + T Q+ Sbjct: 264 MEHRFF------------LSINWQDVVQKKLLPPFK--PQVTSEVDTRYFDDEFTAQS 307 >3I6U-A nrPDB Length = 419 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 131/329 (39%), Gaps = 58/329 (17%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-----EKEGFP-ITALREIKIL 70 +Y +G G GEV A RKT +KVA++ + +E P + EI+IL Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKR 128 + L H ++ + + Y+V + E L V+ + + K Sbjct: 195 KKLNHPCIIKIKNFFDAE---------DYYIVLELMEG--GELFDKVVGNKRLKEATCKL 243 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRY 185 +L + Y+H N I+HRD+K NVL++ D ++K+ DFG ++ + + Sbjct: 244 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL-----GETSLM 298 Query: 186 TNRVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA-LIS 242 T Y PE+L+ G Y +D W G I+ + P + Q L I+ Sbjct: 299 RTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT 358 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + PEVW V ALDL+ KLLV+DP Sbjct: 359 SGKYNFIPEVWAEV----------------------------SEKALDLVKKLLVVDPKA 390 Query: 303 RIDSDDALNHDFFWSDPMPSDLKGMLSTH 331 R +++AL H + + M + +LS Sbjct: 391 RFTTEEALRHPWLQDEDMKRKFQDLLSEE 419 >4CFF-A nrPDB Length = 571 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 133/320 (41%), Gaps = 53/320 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 ++ Y +G GTFG+V H+ TG KVA+K + + + + REI+ L+L Sbjct: 31 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 90 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT---LSEIKRVM 130 +H +++ L ++ T ++V ++ G L + + K E +R+ Sbjct: 91 RHPHIIKLYQVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLF 139 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q +L+ + Y HR+ ++HRD+K NVL+ K+ADFGL+ S + Sbjct: 140 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----LRTSCG 194 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ G GP +D+W G I+ + + Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF--------------------- 233 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 D+ + + ++G + + L V L+ +L +DP +R D Sbjct: 234 ------DDEHVPTLFKKIRGGVFYIPEYLNRSVAT-----LLMHMLQVDPLKRATIKDIR 282 Query: 311 NHDFFWSDPMPSDLKGMLST 330 H++F D +PS L + Sbjct: 283 EHEWFKQD-LPSYLFPEDPS 301 >4CFH-A nrPDB Length = 493 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 73/330 (22%), Positives = 137/330 (41%), Gaps = 53/330 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 ++ Y +G GTFG+V +H TG KVA+K + + + + REI+ L+L Sbjct: 31 KIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLF 90 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIKRVM 130 +H +++ L ++ T + I++V ++ G L + + + E +R+ Sbjct: 91 RHPHIIKLYQVISTPSD--------IFMVMEYVS---GGELFDYICKNGRLDEKESRRLF 139 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q +L+G+ Y HR+ ++HRD+K NVL+ K+ADFGL+ S + Sbjct: 140 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----LRTSCG 194 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ G GP +D+W +G I+ + + + I Sbjct: 195 SPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQ 254 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + +P + L+ +L +DP +R D Sbjct: 255 YL--------------------------------NPSVISLLKHMLQVDPMKRATIKDIR 282 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLA 340 H++F D +P L ++ ++M + A Sbjct: 283 EHEWFKQD-LPKYLFPEDPSYSSTMIDDEA 311 >2UV2-A nrPDB Length = 325 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 81/321 (25%), Positives = 138/321 (42%), Gaps = 49/321 (15%) Query: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT 62 KQY+ V E +E + ++G G FG+V+KA++++T A K + ++E+E Sbjct: 24 KQYEHVTRDLNPE-DFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEE--LED 80 Query: 63 ALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-F 121 + EI IL H N+V L++ + +++++ +FC + L + Sbjct: 81 YMVEIDILASCDHPNIVKLLDAFYY--------ENNLWILIEFCAGGAVDAVMLELERPL 132 Query: 122 TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 T S+I+ V + L+ L Y+H NKI+HRD+KA N+L T DG +KLADFG++ Sbjct: 133 TESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK----NTRT 188 Query: 182 PNRYTNRVVTLWYRPPELLL----GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 R + + T ++ PE+++ +R Y D+W G + EM P Sbjct: 189 IQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP--------- 239 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 ++EL L+K K + + D + K L Sbjct: 240 --------------------HHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLE 279 Query: 298 LDPAQRIDSDDALNHDFFWSD 318 + R + L H F D Sbjct: 280 KNVDARWTTSQLLQHPFVTVD 300 >5EZV-A nrPDB Length = 560 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 133/320 (41%), Gaps = 53/320 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 ++ Y +G GTFG+V H+ TG KVA+K + + + + REI+ L+L Sbjct: 26 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 85 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT---LSEIKRVM 130 +H +++ L ++ T ++V ++ G L + + K E +R+ Sbjct: 86 RHPHIIKLYQVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLF 134 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q +L+ + Y HR+ ++HRD+K NVL+ K+ADFGL+ S + Sbjct: 135 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----LRTSCG 189 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ G GP +D+W G I+ + + Sbjct: 190 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF--------------------- 228 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 D+ + + ++G + + L V L+ +L +DP +R D Sbjct: 229 ------DDEHVPTLFKKIRGGVFYIPEYLNRSVAT-----LLMHMLQVDPLKRATIKDIR 277 Query: 311 NHDFFWSDPMPSDLKGMLST 330 H++F D +PS L + Sbjct: 278 EHEWFKQD-LPSYLFPEDPS 296 >3DAK-A nrPDB Length = 290 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 126/317 (39%), Gaps = 40/317 (12%) Query: 10 CPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI 69 P+ YE IG G V A +KVA+K++ +E + L+EI+ Sbjct: 3 LPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDE-LLKEIQA 61 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVK-------F 121 + H N+V+ K ++LV + ++ +++ K Sbjct: 62 MSQCHHPNIVSYYTSFVV--------KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVL 113 Query: 122 TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 S I +++ +L GL Y+H+N +HRD+KA N+L+ DG +++ADFG++ + + Sbjct: 114 DESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDIT 173 Query: 182 PNR-YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 N+ V T + PE++ R Y D+W G E+ T + + + + Sbjct: 174 RNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYH---KYPPMKV 230 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 + + P + V + E+ +K +I L DP Sbjct: 231 LMLTLQNDPPSLETGVQDKEMLKKYGK-------------------SFRKMISLCLQKDP 271 Query: 301 AQRIDSDDALNHDFFWS 317 +R + + L H FF Sbjct: 272 EKRPTAAELLRHKFFQK 288 >1KOA-A nrPDB Length = 491 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 74/351 (21%), Positives = 131/351 (37%), Gaps = 49/351 (13%) Query: 3 KQY--DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 KQY VE + Y+ ++G G FG V + R TG A K V+ +E + Sbjct: 35 KQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK-- 92 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV 119 T +EI+ + +L+H +VNL + + ++++F +L +++ Sbjct: 93 ETVRKEIQTMSVLRHPTLVNLHDAFEDD--------NEMVMIYEFMSGGELFEKVADEHN 144 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLA 177 K + E M+ + GL ++H N +H D+K N++ T R LKL DFGL Sbjct: 145 KMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPK 204 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 ++ + T + PE+ G + G D+W G + + + G + Sbjct: 205 QSVKVTT-----GTAEFAAPEVAEG-KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDET 258 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 L + K + D + + D I KLL+ Sbjct: 259 LRNV---------------------------KSCDWNMDDSAFSGI-SEDGKDFIRKLLL 290 Query: 298 LDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQ 348 DP R+ AL H + P + S+ T + + + + Sbjct: 291 ADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPE 341 >1U5R-A nrPDB Length = 348 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 85/354 (24%), Positives = 142/354 (40%), Gaps = 50/354 (14%) Query: 3 KQYDSVECPFCDEVSK-YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 K D E F D+ K + L +IG G+FG V+ AR + + VA+KK+ ++ Sbjct: 39 KDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKW 98 Query: 62 T-ALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 ++E++ LQ L+H N + + + +LV ++C + LL Sbjct: 99 QDIIKEVRFLQKLRHPNTIQYRGCYLREHTA--------WLVMEYCLGSASDLLEVHKKP 150 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 EI V L GL Y+H + ++HRD+KA N+L++ G++KL DFG A + A Sbjct: 151 LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA--- 207 Query: 181 QPNRYTNRVVTLWYRPPELLLG--ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 + V T ++ PE++L E Y +D+W G E+ R P + L Sbjct: 208 -----NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSAL 262 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 I+Q L++ Y + +D L Sbjct: 263 YHIAQ------------------------------NESPALQSGHWSEYFRNFVDSCLQK 292 Query: 299 DPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQ 352 P R S+ L H F + P+ + ++ ++ E RK +I Q Sbjct: 293 IPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQ 346 >3TAC-A nrPDB Length = 361 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 80/311 (25%), Positives = 131/311 (42%), Gaps = 56/311 (18%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG---FPITALREIKILQLLKH 75 YE IG+G F V + +R+TGQ+ A+K V + RE I +LKH Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK------FTLSEIKRV 129 ++V L+E + G +Y+VF+F + A L ++ + ++ + Sbjct: 88 PHIVELLETYSSD--------GMLYMVFEFMDG--ADLCFEIVKRADAGFVYSEAVASHY 137 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ +L L Y H N I+HRD+K VL+ +KL FG+A + Sbjct: 138 MRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVA----G 193 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 RV T + PE++ YG P+D+WG G I+ + + G T++ I + Sbjct: 194 GRVGTPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKY 251 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P W ++ A DL+ ++L+LDPA+RI Sbjct: 252 KMNPRQWSHI----------------------------SESAKDLVRRMLMLDPAERITV 283 Query: 307 DDALNHDFFWS 317 +ALNH + Sbjct: 284 YEALNHPWLKE 294 >3D2K-A nrPDB Length = 272 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 122/302 (40%), Gaps = 48/302 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLK 74 + ++ +G+G FG V+ AR R++ +ALK + EK G RE++I L+ Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H N++ L +YL+ ++ L +F + L Sbjct: 71 HPNILRLYGYFHDAT--------RVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELA 122 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 N L Y H +++HRD+K N+L+ +G LK+ADFG + ++ +R T TL Y Sbjct: 123 NALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWS------VHAPSSRRTTLCGTLDY 176 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PPE++ G R + +DLW G + E P + +T Q IS++ + Sbjct: 177 LPPEMIEG-RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPD---- 231 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 A DLI +LL + +QR+ + L H + Sbjct: 232 ----------------------------FVTEGARDLISRLLKHNASQRLTLAEVLEHPW 263 Query: 315 FW 316 Sbjct: 264 IK 265 >4UZD-A nrPDB Length = 287 Score = 237 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 121/302 (40%), Gaps = 48/302 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLK 74 + +E +G+G FG V+ AR +++ +ALK + EK G RE++I L+ Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H N++ L +YL+ ++ L KF + L Sbjct: 67 HPNILRLYGYFHDAT--------RVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELA 118 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 N L Y H +++HRD+K N+L+ G LK+ADFG + ++ +R T TL Y Sbjct: 119 NALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS------VHAPSSRRTTLCGTLDY 172 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PPE++ G R + +DLW G + E P + NT Q IS++ + Sbjct: 173 LPPEMIEG-RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPD---- 227 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 A DLI +LL +P+QR + L H + Sbjct: 228 ----------------------------FVTEGARDLISRLLKHNPSQRPMLREVLEHPW 259 Query: 315 FW 316 Sbjct: 260 IT 261 >4CZT-A nrPDB Length = 464 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 119/310 (38%), Gaps = 43/310 (13%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLLK 74 V KYE +G+GTF +V AR+ + G VA+K + E K REI ++L+K Sbjct: 10 VGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIK 69 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H NV+ + E+ +K IY V +F + + E ++ Q L+ Sbjct: 70 HPNVIRMFEVMASKT--------KIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLI 121 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 N + Y H + HRD+K N+L+ +G LK++DFGL+ + + T Y Sbjct: 122 NAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSAL--PQQVREDGLLHTTCGTPNY 179 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ + G DLW G I+ + + + I + + P Sbjct: 180 VAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWF-- 237 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 A LI ++L +PA RI + + +++ Sbjct: 238 ------------------------------SASAKKLIKRILDPNPATRITFAEVIENEW 267 Query: 315 FWSDPMPSDL 324 F Sbjct: 268 FKKGYKAPKF 277 >2Y7J-A nrPDB Length = 365 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 128/315 (40%), Gaps = 59/315 (18%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEK------EGFPITALREIKILQ 71 KY+ IG+G V + HR TG + A+K + + E+ E RE IL+ Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 72 LL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIK 127 + H +++ LI+ + + ++LVFD G L + L + + E + Sbjct: 155 QVAGHPHIITLIDSYESSS--------FMFLVFDLMR---KGELFDYLTEKVALSEKETR 203 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 +M+ LL + ++H N I+HRD+K N+L+ + ++L+DFG + + + Sbjct: 204 SIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGE-----KLRE 258 Query: 188 RVVTLWYRPPELLLGER-----DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 T Y PE+L YG +DLW G I+ + SP + L +I Sbjct: 259 LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIM 318 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + + W + R DLI +LL +DP Sbjct: 319 EGQYQFSSPEWDD----------------------------RSSTVKDLISRLLQVDPEA 350 Query: 303 RIDSDDALNHDFFWS 317 R+ ++ AL H FF Sbjct: 351 RLTAEQALQHPFFER 365 >4B6L-A nrPDB Length = 281 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 116/308 (37%), Gaps = 46/308 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHEN 77 Y K +G+G F ++A +TG A+K + K L EI++ + L+H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 +V +IY+ + C + E++ ++ +L+GL Sbjct: 71 IVRFSHHFED--------ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGL 122 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+H+ ILHRD+K N IT + LK+ DFGLA + R T Y P Sbjct: 123 KYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPE----QRKKTICGTPNYVAP 178 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E+LL + +GP D+W GC+M + SP + + I Q+ ++ + Sbjct: 179 EVLL-RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASL----- 232 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 A L+ +L P R D L HDFF Sbjct: 233 ---------------------------SLPARQLLAAILRASPRDRPSIDQILRHDFFTK 265 Query: 318 DPMPSDLK 325 P L Sbjct: 266 GYTPDRLP 273 >5D7A-A nrPDB Length = 308 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 78/334 (23%), Positives = 134/334 (40%), Gaps = 46/334 (13%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 D +E + +G GT+G+V+K RH KTGQ A+K + + ++E +EI +L+ Sbjct: 12 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLK 68 Query: 72 LL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVK-FTLSEIKR 128 H N+ K P ++LV +FC + L+ N I Sbjct: 69 KYSHHRNIATYYGAFIKKNPP--GMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAY 126 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + + +L GL ++H++K++HRD+K NVL+T + +KL DFG++ + R Sbjct: 127 ICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGRRNTF 182 Query: 189 VVTLWYRPPELLLGERD----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 + T ++ PE++ + + Y DLW G EM +P + L LI Sbjct: 183 IGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI--- 239 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 R RLK+ I+ LV + +QR Sbjct: 240 ---------------------------PRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRP 272 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEY 338 ++ + H F P ++ L H+ + Sbjct: 273 ATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKK 306 >4CQG-A nrPDB Length = 331 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 75/351 (21%), Positives = 131/351 (37%), Gaps = 53/351 (15%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 + + + YE IG G F +V A H TG+ VA+K + P EI L Sbjct: 3 DYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLP-RVKTEIDAL 61 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIK 127 + L+H+++ L + T K I++V ++C G L + + + + E + Sbjct: 62 KSLRHQHICQLYHVLET--------KNKIFMVLEYCP---GGELFDYIISQDRLSEEETR 110 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 V + +L+ + Y+H HRD+K N+L + LKL DFGL K+ Sbjct: 111 VVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQEC-- 168 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 +L Y PEL+ G+ G D+W G ++ + + I + Sbjct: 169 -CGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYE 227 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 + + P ++ L+ ++L +DP +RI Sbjct: 228 VPKWL--------------------------------SPSSILLLQQMLQVDPKKRISMR 255 Query: 308 DALNHDFFWSD---PMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTN 355 + LNH + D P+ K L+ L+ R Q + + Sbjct: 256 NLLNHPWVMQDYSCPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLIS 306 >4JXF-A nrPDB Length = 266 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 127/303 (41%), Gaps = 47/303 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQL 72 +++ ++ +G+G+F V++A TG +VA+K + + K G E+KI Sbjct: 4 EKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQ 63 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVMQ 131 LKH +++ L +YLV + C ++ L N + F+ +E + M Sbjct: 64 LKHPSILELYNYFEDS--------NYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMH 115 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 ++ G+ Y+H + ILHRD+ +N+L+TR+ +K+ADFGLA + ++ T Sbjct: 116 QIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPH----EKHYTLCGT 171 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PE + +G D+W GC+ + P +T ++ L + Sbjct: 172 PNYISPE-IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV--------- 221 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + D A DLI +LL +PA R+ L+ Sbjct: 222 -----------------------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLD 258 Query: 312 HDF 314 H F Sbjct: 259 HPF 261 >2YZA-A nrPDB Length = 276 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 133/316 (42%), Gaps = 53/316 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLL 73 ++ Y +G GTFG+V H+ TG KVA+K + + + + REI+ L+L Sbjct: 9 KIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF 68 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT---LSEIKRVM 130 +H +++ L ++ T ++V ++ G L + + K E +R+ Sbjct: 69 RHPHIIKLYQVISTPTD--------FFMVMEYVS---GGELFDYICKHGRVEEMEARRLF 117 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q +L+ + Y HR+ ++HRD+K NVL+ K+ADFGL+ S + + Sbjct: 118 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-----LRDSCG 172 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ G GP +D+W G I+ + + Sbjct: 173 SPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF--------------------- 211 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 D+ + + ++G + + L V L+ +L +DP +R D Sbjct: 212 ------DDEHVPTLFKKIRGGVFYIPEYLNRSVAT-----LLMHMLQVDPLKRATIKDIR 260 Query: 311 NHDFFWSDPMPSDLKG 326 H++F D +PS L Sbjct: 261 EHEWFKQD-LPSYLFP 275 >1PHK-A nrPDB Length = 298 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 124/322 (38%), Gaps = 60/322 (18%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-------NEKEGFPITALREIKI 69 YE +G+G V + H+ T ++ A+K + + E + L+E+ I Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 70 LQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSE 125 L+ + H N++ L + T +LVFD + G L + L + + E Sbjct: 77 LRKVSGHPNIIQLKDTYETNT--------FFFLVFDLMK---KGELFDYLTEKVTLSEKE 125 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 +++M+ LL + +H+ I+HRD+K N+L+ D +KL DFG + + + Sbjct: 126 TRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE-----KL 180 Query: 186 TNRVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 T Y PE++ YG +D+W G IM + SP + L + Sbjct: 181 REVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRM 240 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 I W + + DL+ + LV+ P Sbjct: 241 IMSGNYQFGSPEWDDYSDT----------------------------VKDLVSRFLVVQP 272 Query: 301 AQRIDSDDALNHDFFWSDPMPS 322 +R +++AL H FF + Sbjct: 273 QKRYTAEEALAHPFFQQYVVEE 294 >5KKR-C nrPDB Length = 395 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 134/330 (40%), Gaps = 30/330 (9%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 126 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V + G I + + + + + + +V ++ G Sbjct: 127 YIVGFYGAFYSD--------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 178 Query: 137 LYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L Y+ ++KI+HRD+K +N+L+ G +KL DFG++ + + V T Y Sbjct: 179 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DSMANSFVGTRSYM 232 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE L G Y D+W G + EM PI + ++ +L Q+ G Sbjct: 233 SPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 291 Query: 255 -----------NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 +D+ EL+ + +L + V D ++K L+ +PA+R Sbjct: 292 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAER 351 Query: 304 IDSDDALNHDFFW-SDPMPSDLKGMLSTHL 332 D + H F SD D G L + + Sbjct: 352 ADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 381 >4CRL-A nrPDB Length = 406 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 109/364 (29%), Positives = 173/364 (47%), Gaps = 41/364 (11%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQK--VALKKVLMENEKEGFPITAL 64 S E +++ +YE K+G+GT+G V+KA+ + ALK++ E G ++A Sbjct: 13 SSERERVEDLFEYE-GCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSAC 67 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS--------N 116 REI +L+ LKH NV++L ++ + A ++L+FD+ EHDL ++ Sbjct: 68 REIALLRELKHPNVISLQKVFLSHADR------KVWLLFDYAEHDLWHIIKFHRASKANK 121 Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT----RDGVLKLADFGLAR 172 V+ +K ++ +L+G++Y+H N +LHRD+K AN+L+ G +K+AD G AR Sbjct: 122 KPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR 181 Query: 173 AFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 F+ + VVT WYR PELLLG R Y ID+W GCI AE+ T PI Sbjct: 182 LFNSPLKPLAD-LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR 240 Query: 233 TEQ---------HQLALISQLCGSITPEVWPNVDNYE----LYEKLELVKGQKRKVKDRL 279 E QL I + G + W ++ L + + + Sbjct: 241 QEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM 300 Query: 280 KAYVRDPY--ALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFE 337 + + P A L+ KLL +DP +RI S+ A+ +F DP+P+ E Sbjct: 301 EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKRE 360 Query: 338 YLAP 341 +L Sbjct: 361 FLTE 364 >5DBX-A nrPDB Length = 328 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 74/348 (21%), Positives = 137/348 (39%), Gaps = 42/348 (12%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 +V P C + YE IG G V A + ++VA+K++ +E + L+ Sbjct: 2 QAVGWPICRDA--YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE-LLK 58 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVK---- 120 EI+ + H NVV K ++LV + ++ ++ + Sbjct: 59 EIQAMSQCSHPNVVTYYTSFVV--------KDELWLVMKLLSGGSMLDIIKYIVNRGEHK 110 Query: 121 ---FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 + I +++ +L GL Y+HRN +HRD+KA N+L+ DG +++ADFG++ + Sbjct: 111 NGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATG 170 Query: 178 KNSQPNR-YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQH 236 + N+ + V T + PE++ R Y D+W G E+ T + + Sbjct: 171 GDVTRNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYH---KYP 227 Query: 237 QLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLL 296 + ++ + P + V++ E+ +K L+ L Sbjct: 228 PMKVLMLTLQNDPPTLETGVEDKEMMKKYGK-------------------SFRKLLSLCL 268 Query: 297 VLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRR 344 DP++R + + L FF L L T + + RR Sbjct: 269 QKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRR 316 >6O6Q-A nrPDB Length = 335 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 90/319 (28%), Positives = 149/319 (46%), Gaps = 27/319 (8%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 YD + + + YE L K+G+G + EVF + +KV +K + K+ Sbjct: 29 DYDDLNIKWNPQ-ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK-----I 82 Query: 64 LREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 REI IL+ L N++ ++++ R S L+F+ + ++ FT Sbjct: 83 KREISILKNLVDGPNIIAMLDVVREPQSKTPG------LIFEHINNI---DFRSLYPTFT 133 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-LKLADFGLARAFSLAKNSQ 181 +I+ M LL L Y H I+HRD+K NV+I D L+L D+GLA + Sbjct: 134 DYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPG---- 189 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLAL 240 Y RV + +++ PELL+ R Y +D+W GC++A M + + P G + QL Sbjct: 190 -TEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQ 248 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELV----KGQKRKVKDRLKAYVRDPYALDLIDKLL 296 I ++ GS + + N L E+ E + K Q + + + LDLID+LL Sbjct: 249 IVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLL 308 Query: 297 VLDPAQRIDSDDALNHDFF 315 D +R+ + +A+ H +F Sbjct: 309 RYDHQERLTAKEAMKHAYF 327 >4LG4-A nrPDB Length = 299 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 130/316 (41%), Gaps = 47/316 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++ L K+G+G++G VFKA H+++GQ VA+K+V E ++EI I+Q V Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV----PVESDLQEIIKEISIMQQCDSPYV 68 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V +++V ++C ++ ++ EI +++ L GL Sbjct: 69 VKYYGSYFKNTD--------LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 120 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+H + +HR++KA N+L+ +G KLADFG+A + + + T ++ P Sbjct: 121 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLT----DTMAKRNTVIGTPFWMAP 176 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E++ E Y D+W G EM P + H + I + + P Sbjct: 177 EVI-QEIGYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPPPTF----- 227 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 K + D + K LV +P QR + L H F + Sbjct: 228 ---------------------RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 Query: 318 DPMPSDLKGMLSTHLT 333 S L+ +++ + Sbjct: 267 AKPVSILRDLITEAME 282 >2J90-A nrPDB Length = 304 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 116/308 (37%), Gaps = 50/308 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP----ITALREIKILQL 72 YE ++G G F V K R + TG++ A K + RE+ IL+ Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 ++H N++ L +I K + L+ + T E + ++ Sbjct: 86 IRHPNIITLHDIFENKTD--------VVLILELVSGGELFDFLAEKESLTEDEATQFLKQ 137 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTNR 188 +L+G++Y+H +I H D+K N+++ V +KL DFG+A N + N Sbjct: 138 ILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG-----NEFKNI 192 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 T + PE++ G D+W G I + + + G T+Q L IS + Sbjct: 193 FGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDF 251 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 E + N A D I +LLV DP +R+ Sbjct: 252 DEEYFSN----------------------------TSELAKDFIRRLLVKDPKRRMTIAQ 283 Query: 309 ALNHDFFW 316 +L H + Sbjct: 284 SLEHSWIK 291 >3F3Z-A nrPDB Length = 277 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 87/305 (28%), Positives = 127/305 (41%), Gaps = 52/305 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y IG+G++GEV A + T + A KK+ ++ +EI+I++ L H N+ Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDR--FKQEIEIMKSLDHPNI 68 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 + L E IYLV + C L V+ K F S+ R+M+ +L+ Sbjct: 69 IRLYETFEDNTD--------IYLVMELCTG--GELFERVVHKRVFRESDAARIMKDVLSA 118 Query: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y H+ + HRD+K N L + D LKL DFGLA F K +V T + Sbjct: 119 VAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKM-----MRTKVGTPY 173 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y P++L G YGP D W AG +M + P T+ + I + + + W Sbjct: 174 YVSPQVLEG--LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDW 231 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 NV P A LI +LL P QRI S AL H+ Sbjct: 232 LNV----------------------------SPQAESLIRRLLTKSPKQRITSLQALEHE 263 Query: 314 FFWSD 318 +F Sbjct: 264 WFEKQ 268 >4FIE-A nrPDB Length = 423 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 134/322 (41%), Gaps = 49/322 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK+ + K+ E+ I++ Sbjct: 148 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMRDY 205 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV--KFTLSEIKRVMQ 131 +HENVV + +++V +F E G L++++ + +I V Sbjct: 206 QHENVVEMYNSY--------LVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCL 254 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L L +H ++HRD+K+ ++L+T DG +KL+DFG S + R + V T Sbjct: 255 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK----EVPRRKSLVGT 310 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PEL+ YGP +D+W G ++ EM P + +I Sbjct: 311 PYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 363 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + P +D+LLV DPAQR + + L Sbjct: 364 -----------------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 400 Query: 312 HDFFWSDPMPSDLKGMLSTHLT 333 H F P+ + ++ + T Sbjct: 401 HPFLAKAGPPASIVPLMRQNRT 422 >4D2V-A nrPDB Length = 356 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 121/312 (38%), Gaps = 50/312 (16%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 + + + YE IG G F +V A H TG+ VA+K + P EI+ L Sbjct: 23 DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLP-RIKTEIEAL 81 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL---VKFTLSEIK 127 + L+H+++ L + T I++V ++C G L + + + + E + Sbjct: 82 KNLRHQHICQLYHVLET--------ANKIFMVLEYCP---GGELFDYIISQDRLSEEETR 130 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 V + +++ + Y+H HRD+K N+L LKL DFGL K+ Sbjct: 131 VVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQAC-- 188 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 L Y PEL+ G+ G D+W G ++ + +T +A I + Sbjct: 189 -CGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYD 247 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 + + P ++ L+ ++L +DP +RI Sbjct: 248 VPKWL--------------------------------SPSSILLLQQMLQVDPKKRISMK 275 Query: 308 DALNHDFFWSDP 319 + LNH + D Sbjct: 276 NLLNHPWIMQDY 287 >2GCD-A nrPDB Length = 309 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 84/353 (23%), Positives = 141/353 (39%), Gaps = 50/353 (14%) Query: 4 QYDSVECPFCDEVSK-YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT 62 D E F D+ K + L +IG G+FG V+ AR + + VA+KK+ ++ Sbjct: 1 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 60 Query: 63 -ALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF 121 ++E++ LQ L+H N + + + +LV ++C + LL Sbjct: 61 DIIKEVRFLQKLRHPNTIQYRGCYLREHTA--------WLVMEYCLGSASDLLEVHKKPL 112 Query: 122 TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 EI V L GL Y+H + ++HRD+KA N+L++ G++KL DFG A + A Sbjct: 113 QEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA---- 168 Query: 182 PNRYTNRVVTLWYRPPELLLG--ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 + V T ++ PE++L E Y +D+W G E+ R P + L Sbjct: 169 ----NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALY 224 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 I+Q L++ Y + +D L Sbjct: 225 HIAQ------------------------------NESPALQSGHWSEYFRNFVDSCLQKI 254 Query: 300 PAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQ 352 P R S+ L H F + P+ + ++ ++ E RK +I Q Sbjct: 255 PQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQ 307 >4JDH-A nrPDB Length = 346 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 134/322 (41%), Gaps = 49/322 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK+ + K+ E+ I++ Sbjct: 71 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMRDY 128 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV--KFTLSEIKRVMQ 131 +HENVV + +++V +F E G L++++ + +I V Sbjct: 129 QHENVVEMYNSY--------LVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCL 177 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L L +H ++HRD+K+ ++L+T DG +KL+DFG S + R + V T Sbjct: 178 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK----EVPRRKSLVGT 233 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PEL+ YGP +D+W G ++ EM P + +I Sbjct: 234 PYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 286 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + P +D+LLV DPAQR + + L Sbjct: 287 -----------------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 323 Query: 312 HDFFWSDPMPSDLKGMLSTHLT 333 H F P+ + ++ + T Sbjct: 324 HPFLAKAGPPASIVPLMRQNRT 345 >2JAM-A nrPDB Length = 304 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 115/302 (38%), Gaps = 52/302 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + + +G G F EVF + R TG+ ALK + + EI +L+ +KHEN+ Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD--SSLENEIAVLKKIKHENI 68 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 V L +I + YLV L +L + +T + V+Q +L+ Sbjct: 69 VTLEDIYESTTHY--------YLVMQLVSG--GELFDRILERGVYTEKDASLVIQQVLSA 118 Query: 137 LYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y+H N I+HRD+K N+L + + + DFGL++ Q + T Sbjct: 119 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK------MEQNGIMSTACGTPG 172 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L ++ Y +D W G I + P TE I + W Sbjct: 173 YVAPEVL-AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFW 231 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 ++ A D I LL DP +R + AL+H Sbjct: 232 DDI----------------------------SESAKDFICHLLEKDPNERYTCEKALSHP 263 Query: 314 FF 315 + Sbjct: 264 WI 265 >2Q0N-A nrPDB Length = 301 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 134/322 (41%), Gaps = 49/322 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK+ + K+ E+ I++ Sbjct: 26 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMRDY 83 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV--KFTLSEIKRVMQ 131 +HENVV + +++V +F E G L++++ + +I V Sbjct: 84 QHENVVEMYNSY--------LVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCL 132 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L L +H ++HRD+K+ ++L+T DG +KL+DFG S + R + V T Sbjct: 133 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK----EVPRRKSLVGT 188 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PEL+ YGP +D+W G ++ EM P + +I Sbjct: 189 PYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 241 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + P +D+LLV DPAQR + + L Sbjct: 242 -----------------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 278 Query: 312 HDFFWSDPMPSDLKGMLSTHLT 333 H F P+ + ++ + T Sbjct: 279 HPFLAKAGPPASIVPLMRQNRT 300 >4XBR-A nrPDB Length = 366 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 134/322 (41%), Gaps = 49/322 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D S + KIG+G+ G V A R +G+ VA+KK+ + K+ E+ I++ Sbjct: 91 DPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR--KQQRRELLFNEVVIMRDY 148 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV--KFTLSEIKRVMQ 131 +HENVV + +++V +F E G L++++ + +I V Sbjct: 149 QHENVVEMYNSY--------LVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCL 197 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L L +H ++HRD+K+ ++L+T DG +KL+DFG S + R + V T Sbjct: 198 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSK----EVPRRKSLVGT 253 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PEL+ YGP +D+W G ++ EM P + +I Sbjct: 254 PYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------ 306 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + P +D+LLV DPAQR + + L Sbjct: 307 -----------------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLK 343 Query: 312 HDFFWSDPMPSDLKGMLSTHLT 333 H F P+ + ++ + T Sbjct: 344 HPFLAKAGPPASIVPLMRQNRT 365 >3EQC-A nrPDB Length = 360 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 75/330 (22%), Positives = 134/330 (40%), Gaps = 30/330 (9%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 91 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V + G I + + + + + + +V ++ G Sbjct: 92 YIVGFYGAFYSD--------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 143 Query: 137 LYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L Y+ ++KI+HRD+K +N+L+ G +KL DFG++ + + V T Y Sbjct: 144 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DSMANSFVGTRSYM 197 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE L G Y D+W G + EM PI + ++ +L Q+ G Sbjct: 198 SPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 256 Query: 255 -----------NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 +D+ EL+ + +L + V D ++K L+ +PA+R Sbjct: 257 PRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER 316 Query: 304 IDSDDALNHDFFW-SDPMPSDLKGMLSTHL 332 D + H F SD D G L + + Sbjct: 317 ADLKQLMVHAFIKRSDAEEVDFAGWLCSTI 346 >2HAK-A nrPDB Length = 328 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 69/351 (19%), Positives = 132/351 (37%), Gaps = 49/351 (13%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 + Y IG+G F +V ARH TG++VA+K + RE++I+++L Sbjct: 12 PHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL 71 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H N+V L E+ T+ + +YLV ++ + E + + + Sbjct: 72 NHPNIVKLFEVIETEKT--------LYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 123 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ + Y H+ I+HRD+KA N+L+ D +K+ADFG + F++ N+ + Sbjct: 124 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-----NKLDTFCGSPP 178 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PEL G++ GP +D+W G I+ + + S G + + + I + Sbjct: 179 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 238 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + +N + +P +R + + Sbjct: 239 TDCENLLKKLLVL--------------------------------NPIKRGSLEQIMKDR 266 Query: 314 FFWSDPMPSDLKGMLST----HLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360 + +LK + T + + +I NQ + Sbjct: 267 WMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE 317 >6C9D-A nrPDB Length = 459 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 69/351 (19%), Positives = 132/351 (37%), Gaps = 49/351 (13%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 + Y IG+G F +V ARH TG++VA+K + RE++I+++L Sbjct: 18 PHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKIL 77 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H N+V L E+ T+ + +YLV ++ + E + + + Sbjct: 78 NHPNIVKLFEVIETEKT--------LYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 129 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ + Y H+ I+HRD+KA N+L+ D +K+ADFG + F++ N+ + Sbjct: 130 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG-----NKLDEFCGSPP 184 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PEL G++ GP +D+W G I+ + + S G + + + I + Sbjct: 185 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 244 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + +N + +P +R + + Sbjct: 245 TDCENLLKKLLVL--------------------------------NPIKRGSLEQIMKDR 272 Query: 314 FFWSDPMPSDLKGMLST----HLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360 + +LK + T + + +I NQ + Sbjct: 273 WMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDE 323 >4KS7-A nrPDB Length = 292 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 129/305 (42%), Gaps = 45/305 (14%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG+G+ G V AR + +G++VA+K + + K+ E+ I++ +H NVV + + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLR--KQQRRELLFNEVVIMRDYQHFNVVEMYK 87 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 ++++ +F + + + V+ +I V + +L L Y+H Sbjct: 88 SYLVGEE--------LWVLMEFLQGGALTDIVS-QVRLNEEQIATVCEAVLQALAYLHAQ 138 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE 203 ++HRD+K+ ++L+T DG +KL+DFG S + + V T ++ PE++ Sbjct: 139 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKD----VPKRKSLVGTPYWMAPEVI-SR 193 Query: 204 RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYE 263 Y +D+W G ++ EM P ++ + + Sbjct: 194 SLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD-------------------- 233 Query: 264 KLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323 ++ P D ++++LV DP +R + + L+H F +P Sbjct: 234 ---------SPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPEC 284 Query: 324 LKGML 328 L ++ Sbjct: 285 LVPLI 289 >3GUB-A nrPDB Length = 295 Score = 233 bits (595), Expect = 9e-62, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 125/325 (38%), Gaps = 54/325 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP----ITALREIKILQL 72 Y+ ++G G F V K R + TG + A K + K RE+ IL+ Sbjct: 11 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKE 70 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 ++H NV+ L E+ K + L+ + T E ++ Sbjct: 71 IQHPNVITLHEVYENKTD--------VILIGELVAGGELFDFLAEKESLTEEEATEFLKQ 122 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKNSQPNRYTNR 188 +LNG+YY+H +I H D+K N+++ V +K+ DFGLA N + N Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG-----NEFKNI 177 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 T + PE++ G D+W G I + + + G+T+Q LA +S + Sbjct: 178 FGTPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEF 236 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 E + N A D I +LLV DP +R+ D Sbjct: 237 EDEYFSN----------------------------TSALAKDFIRRLLVKDPKKRMTIQD 268 Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLT 333 +L H + P D + LS+ + Sbjct: 269 SLQHPWIK----PKDTQQALSSAWS 289 >5XZW-A nrPDB Length = 471 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 113/313 (36%), Gaps = 57/313 (18%) Query: 18 KYEKL-AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 + + +GQG F V KA R TG+ A+K + RE+++LQ L H Sbjct: 196 DFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT-RELEVLQKLNHP 254 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V L S Y+V +F + + + +L Sbjct: 255 RIVRLKGFYEDTESY--------YMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306 Query: 137 LYYIHRNKILHRDMKAANVLITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 + YIH I HRD+K N+LI +D +K+ DFGLA+ + TL Y Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKV-----QGNGSFMKTFCGTLAY 361 Query: 195 RPPELLLG------------ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 PE++ G +Y +D+W GC++ + T G+T+ I Sbjct: 362 VAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG 421 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + P LK + A D ID LL +DP Sbjct: 422 RGSYHEGP----------------------------LKDFRISEEARDFIDSLLQVDPNN 453 Query: 303 RIDSDDALNHDFF 315 R + ALNH + Sbjct: 454 RSTAAKALNHPWI 466 >3Q53-A nrPDB Length = 306 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 135/317 (42%), Gaps = 49/317 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D KY + KIGQG G V+ A TGQ+VA++++ ++ + + + EI +++ Sbjct: 18 DPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK--ELIINEILVMREN 75 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQ 131 K+ N+VN ++ +++V ++ G L++V+ + + E I V + Sbjct: 76 KNPNIVNYLDSY--------LVGDELWVVMEYL---AGGSLTDVVTETCMDEGQIAAVCR 124 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L L ++H N+++HRD+K+ N+L+ DG +KL DFG + + ++ + V T Sbjct: 125 ECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP----EQSKRSTMVGT 180 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PE++ + YGP +D+W G + EM P L LI+ Sbjct: 181 PYWMAPEVV-TRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA--------- 230 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + D +++ L +D +R + + + Sbjct: 231 --------------------TNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQ 270 Query: 312 HDFFWSDPMPSDLKGML 328 H F S L ++ Sbjct: 271 HQFLKIAKPLSSLTPLI 287 >5D9K-A nrPDB Length = 330 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 77/360 (21%), Positives = 133/360 (36%), Gaps = 66/360 (18%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + S++E L +GQG+FG+VF + Q A+K + K + E IL Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 + H +V L +T +G +YL+ DF + V FT ++K + Sbjct: 88 EVNHPFIVKLHYAFQT--------EGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 139 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L L ++H I++RD+K N+L+ +G +KL DFGL++ + + T Sbjct: 140 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE----SIDHEKKAYSFCGT 195 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + Y PE++ R + D W G +M EM T + QG + + +I + + Sbjct: 196 VEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQ- 253 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS----- 306 P A L+ L +PA R+ + Sbjct: 254 -------------------------------FLSPEAQSLLRMLFKRNPANRLGAGPDGV 282 Query: 307 DDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQT 366 ++ H FF + L + PP + + +P T +T Sbjct: 283 EEIKRHSFF---------STIDWNKLY--RREIHPPFK--PATGRPEDTFYFDPEFTAKT 329 >4I6B-A nrPDB Length = 308 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 118/320 (36%), Gaps = 46/320 (14%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-LMENEKEGFPITALREIKILQLLKHE 76 +Y + +G+G F + ++ + A K + K +EI++ ++L H+ Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHK 88 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +VV K +IY++ ++C + T E++ ++ +++G Sbjct: 89 HVVQFYHYFEDKE--------NIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSG 140 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 L Y+H +ILHRD+K N I LK+ DFGLA ++ R T Y Sbjct: 141 LKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEH----RRRTICGTPNYLS 196 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 PE+L ++ +G D+W GC+M M P + + I + ++ + Sbjct: 197 PEVL-NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAP- 254 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 A LI +L +P R DD + HDFF Sbjct: 255 -------------------------------AKHLIASMLSKNPEDRPSLDDIIRHDFFT 283 Query: 317 SDPMPSDLKGMLSTHLTSMF 336 P L + Sbjct: 284 QGFTPDRLSSSCCHTVPDFH 303 >6AO5-A nrPDB Length = 362 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 130/316 (41%), Gaps = 47/316 (14%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 ++ L K+G+G++G VFKA H+++GQ VA+K+V E ++EI I+Q V Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV----PVESDLQEIIKEISIMQQCDSPYV 67 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V +++V ++C ++ ++ EI +++ L GL Sbjct: 68 VKYYGSYFKNTD--------LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGL 119 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Y+H + +HR++KA N+L+ +G KLADFG+A + + + T ++ P Sbjct: 120 EYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLT----DTMAKRNTVIGTPFWMAP 175 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 E++ E Y D+W G EM P + H + I + + P Sbjct: 176 EVI-QEIGYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPPPTF----- 226 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 K + D + K LV +P QR + L H F + Sbjct: 227 ---------------------RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 Query: 318 DPMPSDLKGMLSTHLT 333 S L+ +++ + Sbjct: 266 AKPVSILRDLITEAME 281 >4D28-A nrPDB Length = 446 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 71/325 (21%), Positives = 118/325 (36%), Gaps = 45/325 (13%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQ 71 V KYE IG+GTF +V AR+ TG VA+K + K REI I++ Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK 64 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 +++H N+V L E+ +K+ IY+V +F + E ++ Q Sbjct: 65 IVRHPNIVRLYEVLASKS--------KIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQ 116 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L++ + + H + HRD+K N+L+ +G LK++DFGL+ + T Sbjct: 117 QLVDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG----VELLNDTCGT 172 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PE+L G+ G D+W G I+ + I+ P Sbjct: 173 PNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPW 232 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 LI ++L +P RI Sbjct: 233 F--------------------------------SAEVKFLIHRILDPNPKTRIQIQGIKK 260 Query: 312 HDFFWSDPMPSDLKGMLSTHLTSMF 336 +F + +P + +L + Sbjct: 261 DPWFRKNYVPIRAREEEEVNLDDIR 285 >4NIF-A nrPDB Length = 333 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 118/314 (37%), Gaps = 60/314 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHEN 77 Y IG G++ E + H+ T + A+K + EI+IL + +H N Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQHPN 63 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLN 135 ++ L ++ +YLV + LL +L + F+ E V+ + Sbjct: 64 IITLKDVYDDGK--------HVYLVTELMRG--GELLDKILRQKFFSEREASFVLHTIGK 113 Query: 136 GLYYIHRNKILHRDMKAANVL-ITRDGV---LKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + Y+H ++HRD+K +N+L + G L++ DFG A+ ++ T Sbjct: 114 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL----RAENGLLMTPCYT 169 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIM---QGNTEQHQLALISQLCGSI 248 + PE+L + Y D+W G ++ M +T + L I ++ Sbjct: 170 ANFVAPEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 228 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 + W V A DL+ K+L +DP QR+ + Sbjct: 229 SGGNWNTV----------------------------SETAKDLVSKMLHVDPHQRLTAKQ 260 Query: 309 ALNHDFFWS-DPMP 321 L H + D +P Sbjct: 261 VLQHPWVTQKDKLP 274 >2PVN-A nrPDB Length = 352 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 80/321 (24%), Positives = 149/321 (46%), Gaps = 26/321 (8%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Y+++ + ++ YE + K+G+G + EVF+ + + K ++ + Sbjct: 40 DYEALTVQWGEQ-DDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIK 94 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL 123 + L N+V L++I R + S L+F++ + +L T Sbjct: 95 REIKILQNLCGGPNIVKLLDIVRDQHSKTPS------LIFEYVNNTDFKVLY---PTLTD 145 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQP 182 +I+ + LL L Y H I+HRD+K NV+I + L+L D+GLA + K Sbjct: 146 YDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGK---- 201 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMA-EMWTRSPIMQGNTEQHQLALI 241 Y RV + +++ PELL+ +DY +D+W GC+ A ++ + P G+ QL I Sbjct: 202 -EYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKI 260 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK-----DRLKAYVRDPYALDLIDKLL 296 +++ G+ + N EL +LE + G+ + + ++ P A+D +DKLL Sbjct: 261 AKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLL 320 Query: 297 VLDPAQRIDSDDALNHDFFWS 317 D +R+ + +A+ H +F Sbjct: 321 RYDHQERLTALEAMTHPYFQQ 341 >4JG6-A nrPDB Length = 355 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 123/314 (39%), Gaps = 60/314 (19%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHEN 77 YE IG G++ + H+ T + A+K + EI+IL + +H N Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT------EEIEILLRYGQHPN 90 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLN 135 ++ L ++ +Y+V + + LL +L + F+ E V+ + Sbjct: 91 IITLKDVYDDGK--------YVYVVTELMKG--GELLDKILRQKFFSEREASAVLFTITK 140 Query: 136 GLYYIHRNKILHRDMKAANVL-ITRDGV---LKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + Y+H ++HRD+K +N+L + G +++ DFG A+ ++ T Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL----RAENGLLMTPCYT 196 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIM---QGNTEQHQLALISQLCGSI 248 + PE+L + Y D+W G ++ M T +T + LA I S+ Sbjct: 197 ANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 255 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 + W +V + A DL+ K+L +DP QR+ + Sbjct: 256 SGGYWNSVSDT----------------------------AKDLVSKMLHVDPHQRLTAAL 287 Query: 309 ALNHDFFWS-DPMP 321 L H + D +P Sbjct: 288 VLRHPWIVHWDQLP 301 >2F57-A nrPDB Length = 317 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 127/309 (41%), Gaps = 49/309 (15%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 KIG+G+ G V A + TG++VA+KK+ + K+ E+ I++ H+NVV++ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR--KQQRRELLFNEVVIMRDYHHDNVVDMYS 109 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV--KFTLSEIKRVMQMLLNGLYYIH 141 +++V +F E G L++++ + +I V +L L Y+H Sbjct: 110 SY--------LVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIATVCLSVLRALSYLH 158 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 ++HRD+K+ ++L+T DG +KL+DFG S + + + V T ++ PE++ Sbjct: 159 NQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSK----EVPKRKSLVGTPYWMAPEVI- 213 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 YG +D+W G ++ EM P + I Sbjct: 214 SRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL---------------- 257 Query: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMP 321 + +D +LV +P+QR + + L H F P Sbjct: 258 -------------PPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPP 304 Query: 322 SDLKGMLST 330 S + ++ Sbjct: 305 SCIVPLMRQ 313 >3DB8-A nrPDB Length = 317 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 115/311 (36%), Gaps = 46/311 (14%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLK 74 + +Y + +G+G F + ++ T + A K V + + EI I + L Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 + +VV +Y+V + C L T E + M+ + Sbjct: 101 NPHVVGFHGFFEDD--------DFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTI 152 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+H N+++HRD+K N+ + D +K+ DFGLA R + T Y Sbjct: 153 QGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIE----FDGERKKDLCGTPNY 208 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE+L ++ + +D+W GCI+ + P + + + I + S+ + Sbjct: 209 IAPEVL-CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHI-- 265 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 +P A LI ++L DP R + L +F Sbjct: 266 ------------------------------NPVASALIRRMLHADPTLRPSVAELLTDEF 295 Query: 315 FWSDPMPSDLK 325 F S P L Sbjct: 296 FTSGYAPMRLP 306 >6HMD-A nrPDB Length = 365 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 95/345 (27%), Positives = 161/345 (46%), Gaps = 32/345 (9%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Y++ P Y+ + K+G+G + EVF+A + + +V+++ K Sbjct: 41 DYEA-HVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKI 94 Query: 64 LREIKILQLLKHE-NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 RE+KIL+ L+ N++ LI+ + S LVF++ + L +L F Sbjct: 95 KREVKILENLRGGTNIIKLIDTVKDPVSKTPA------LVFEYINNTDFKQLYQILTDF- 147 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQ 181 +I+ M LL L Y H I+HRD+K NV+I L+L D+GLA + A Sbjct: 148 --DIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPA---- 201 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLAL 240 Y RV + +++ PELL+ + Y +D+W GC++A M + R P G QL Sbjct: 202 -QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVR 260 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR-----LKAYVRDPYALDLIDKL 295 I+++ G+ + + +L + GQ + + ++ P ALDL+DKL Sbjct: 261 IAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKL 320 Query: 296 LVLDPAQRIDSDDALNHDFFW----SDPMPSDLKGMLSTHLTSMF 336 L D QR+ + +A+ H +F+ PS +LS+ LT+ Sbjct: 321 LRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSADNAVLSSGLTAAR 365 >6HXF-B nrPDB Length = 302 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 142/342 (41%), Gaps = 49/342 (14%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 +++Y+ V D +E + ++G G FG+V+KA++++TG A K + ++E+E Sbjct: 5 SREYEHVRRDL-DPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE--LE 61 Query: 62 TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK- 120 + EI+IL H +V L+ G ++++ +FC + L + Sbjct: 62 DYIVEIEILATCDHPYIVKLLGAYYHD--------GKLWIMIEFCPGGAVDAIMLELDRG 113 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 T +I+ V + +L L ++H +I+HRD+KA NVL+T +G ++LADFG++ Sbjct: 114 LTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAK----NLK 169 Query: 181 QPNRYTNRVVTLWYRPPELL----LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQH 236 + + + T ++ PE++ + + Y D+W G + EM P Sbjct: 170 TLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPP-------- 221 Query: 237 QLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLL 296 ++EL L+K K L D + L Sbjct: 222 ---------------------HHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIAL 260 Query: 297 VLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEY 338 +P R + L H F S L+ +++ + E Sbjct: 261 DKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 302 >4L42-A nrPDB Length = 346 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 77/369 (20%), Positives = 139/369 (37%), Gaps = 55/369 (14%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMENEKEGFPITA--LR 65 P +E L +G+G +G+VF+ R TG+ A+K + TA Sbjct: 12 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 71 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE 125 E IL+ +KH +V+LI +T G +YL+ ++ + F Sbjct: 72 ERNILEEVKHPFIVDLIYAFQTG--------GKLYLILEYLSGGELFMQLEREGIFMEDT 123 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 + + L ++H+ I++RD+K N+++ G +KL DFGL + Sbjct: 124 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE----SIHDGTVT 179 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 T+ Y PE+L+ + +D W G +M +M T +P G + + I + Sbjct: 180 HTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK 238 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI- 304 ++ P + A DL+ KLL + A R+ Sbjct: 239 LNLPPYL--------------------------------TQEARDLLKKLLKRNAASRLG 266 Query: 305 ----DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP 360 D+ + H FF L + + + + S+ T+Q+ S + Sbjct: 267 AGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDD 326 Query: 361 ATTNQTEFE 369 +T ++ E E Sbjct: 327 STLSEEEQE 335 >2YAB-A nrPDB Length = 361 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 66/318 (20%), Positives = 116/318 (36%), Gaps = 54/318 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP----ITALREIKILQLLK 74 Y+ ++G G F V K R + TG + A K + + RE+ IL+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H N++ L ++ + + L+ + + E ++ +L Sbjct: 74 HPNIITLHDVYENRTD--------VVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDG----VLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H KI H D+K N+++ +KL DFGLA + N Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG-----VEFKNIFG 180 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T + PE++ G D+W G I + + + G+T+Q LA I+ + Sbjct: 181 TPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDE 239 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E + A D I KLLV + +R+ +AL Sbjct: 240 EFFSQ----------------------------TSELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 311 NHDFFWSDPMPSDLKGML 328 H + P D + + Sbjct: 272 RHPWIT----PVDTQQAM 285 >2W4O-A nrPDB Length = 349 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 118/302 (39%), Gaps = 54/302 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E +++G+G V++ + + T + ALK + +K+ EI +L L H N+ Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLSHPNI 110 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNG 136 + L EI T I LV + L ++ K ++ + ++ +L Sbjct: 111 IKLKEIFETPTE--------ISLVLELVTG--GELFDRIVEKGYYSERDAADAVKQILEA 160 Query: 137 LYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + Y+H N I+HRD+K N+L D LK+ADFGL++ T Sbjct: 161 VAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVE-----HQVLMKTVCGTPG 215 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTR-SPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE+L G YGP +D+W G I + P +Q I Sbjct: 216 YCAPEILRG-CAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPW 274 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 W V A DL+ KL+VLDP +R+ + AL H Sbjct: 275 WDEV----------------------------SLNAKDLVRKLIVLDPKKRLTTFQALQH 306 Query: 313 DF 314 + Sbjct: 307 PW 308 >2OU7-A nrPDB Length = 335 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 116/302 (38%), Gaps = 46/302 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLIE 83 +G+G F + F+ T + A K V + + EI I + L H++VV Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 +++V + C L T E + ++ ++ G Y+HRN Sbjct: 109 FFEDN--------DFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN 160 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE 203 +++HRD+K N+ + D +K+ DFGLA R T Y PE+L + Sbjct: 161 RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVE----YDGERKKVLCGTPNYIAPEVL-SK 215 Query: 204 RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYE 263 + + +D+W GCIM + P + + + I + SI + Sbjct: 216 KGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHI----------- 264 Query: 264 KLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323 +P A LI K+L DP R ++ LN +FF S +P+ Sbjct: 265 ---------------------NPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPAR 303 Query: 324 LK 325 L Sbjct: 304 LP 305 >2HW6-A nrPDB Length = 307 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 119/303 (39%), Gaps = 34/303 (11%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVNL 81 +G+G + +V A + G++ A+K + E + RE++ L + ++N++ L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQCQGNKNILEL 76 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIH 141 IE YLVF+ + F E RV++ + L ++H Sbjct: 77 IEFFEDDT--------RFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 128 Query: 142 RNKILHRDMKAANVLITRD---GVLKLADFGLARAFSLAKNSQP---NRYTNRVVTLWYR 195 I HRD+K N+L +K+ DF L L + P T + Y Sbjct: 129 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM 188 Query: 196 PPELLLGERD----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 PE++ D Y DLW G ++ M + P G+ CG E Sbjct: 189 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--------CGWDRGE 240 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 V N + E ++ K + D+ A++ A DLI KLLV D QR+ + L Sbjct: 241 VCRVCQN----KLFESIQEGKYEFPDKDWAHISS-EAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 312 HDF 314 H + Sbjct: 296 HPW 298 >5J5T-A nrPDB Length = 370 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 79/364 (21%), Positives = 143/364 (39%), Gaps = 50/364 (13%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +E + +IG GT+G+V+KAR+ TG+ A+K + +E ++ +EI +++ KH Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED--FAVVQQEIIMMKDCKHP 61 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 N+V + +++ +FC + +V + +I V + L G Sbjct: 62 NIVAYFGSY--------LRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQG 113 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 LYY+H +HRD+K AN+L+T +G +KLADFG++ + + + + T ++ Sbjct: 114 LYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQIT----ATIAKRKAFIGTPYWMA 169 Query: 197 PELLLGER--DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE+ ER Y DLW G E+ P M L L+++ Sbjct: 170 PEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP----- 224 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314 K+KD++K + L +P +R ++ L H F Sbjct: 225 -------------------KLKDKMK---WSNSFHHFVKMALTKNPKKRPTAEKLLQHPF 262 Query: 315 FWSDPMPSDLKGMLS-------THLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTE 367 S +L + + P ++ R T ++ Sbjct: 263 VTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEIT 322 Query: 368 FERV 371 F +V Sbjct: 323 FGQV 326 >5X8I-B nrPDB Length = 346 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 133/337 (39%), Gaps = 58/337 (17%) Query: 18 KYEKLAKIGQGTFGEVFKAR-HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-- 74 +YE + +G+G FG+V + H+ G+ VA+K V + + A EI++L+ L Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIV---KNVDRYCEAARSEIQVLEHLNTT 70 Query: 75 HEN----VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRV 129 N V ++E G I +VF+ + N + F L I+++ Sbjct: 71 DPNSTFRCVQMLEWFEH--------HGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKM 122 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-------------------LKLADFGL 170 + + ++H NK+ H D+K N+L + +K+ DFG Sbjct: 123 AYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGS 182 Query: 171 ARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQ 230 A ++ V T YR PE++L + P D+W GCI+ E + + Sbjct: 183 AT-------YDDEHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVFP 234 Query: 231 GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR------------ 278 + + LA++ ++ G + + + + L + Sbjct: 235 THDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFM 294 Query: 279 LKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 L V DLI K+L DPA+RI +AL H FF Sbjct: 295 LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4J52-A nrPDB Length = 293 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 116/302 (38%), Gaps = 46/302 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLKHENVVNLIE 83 +G+G F + F+ T + A K V + + EI I + L H++VV Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 +++V + C L T E + ++ ++ G Y+HRN Sbjct: 82 FFEDN--------DFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN 133 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE 203 +++HRD+K N+ + D +K+ DFGLA R T Y PE+L + Sbjct: 134 RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVE----YDGERKKVLCGTPNYIAPEVL-SK 188 Query: 204 RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYE 263 + + +D+W GCIM + P + + + I + SI + Sbjct: 189 KGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHI----------- 237 Query: 264 KLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323 +P A LI K+L DP R ++ LN +FF S +P+ Sbjct: 238 ---------------------NPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPAR 276 Query: 324 LK 325 L Sbjct: 277 LP 278 >4MD7-E nrPDB Length = 391 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 86/322 (26%), Positives = 153/322 (47%), Gaps = 28/322 (8%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Y+S + ++ Y+ + K+G+G + EVF+A + +K V+++ K Sbjct: 25 DYESHVVEWGNQ-DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKI 78 Query: 64 LREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 REIKIL+ L+ N++ L +I + S LVF+ + L L + Sbjct: 79 KREIKILENLRGGPNIITLADIVKDPVSRTPA------LVFEHVNNTDFKQLYQTLTDY- 131 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQ 181 +I+ M +L L Y H I+HRD+K NV+I L+L D+GLA + Sbjct: 132 --DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG---- 185 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLAL 240 Y RV + +++ PELL+ + Y +D+W GC++A M + + P G+ QL Sbjct: 186 -QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 244 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR-----LKAYVRDPYALDLIDKL 295 I+++ G+ + + N EL + + G+ + + ++ P ALD +DKL Sbjct: 245 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 304 Query: 296 LVLDPAQRIDSDDALNHDFFWS 317 L D R+ + +A+ H +F++ Sbjct: 305 LRYDHQSRLTAREAMEHPYFYT 326 >4U41-A nrPDB Length = 332 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 77/338 (22%), Positives = 128/338 (37%), Gaps = 46/338 (13%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 D +E + +G GT+G+V+K RH KTGQ A+K + + E EI +L+ Sbjct: 19 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM---DVTEDEEEEIKLEINMLK 75 Query: 72 LL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL--SNVLVKFTLSEIKR 128 H N+ K+ P + ++LV +FC L + I Sbjct: 76 KYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAY 133 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + + +L GL ++H + ++HRD+K NVL+T + +KL DFG++ + R Sbjct: 134 ISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL----DRTVGRRNTF 189 Query: 189 VVTLWYRPPELLLGERD----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 + T ++ PE++ + + Y DLW G EM +P + L LI Sbjct: 190 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLI--- 246 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 R RLK+ I+ LV + QR Sbjct: 247 ---------------------------PRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRP 279 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPP 342 ++ L H F P ++ L H+ + Sbjct: 280 STEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEK 317 >4PDS-A nrPDB Length = 347 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 114/318 (35%), Gaps = 57/318 (17%) Query: 18 KYEKL-AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 + + +GQG F V KA R TG+ ++K + RE+++LQ L H Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVT-RELEVLQKLNHP 89 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V L S Y+V +F + + + +L Sbjct: 90 RIVRLKGFYEDTESY--------YMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 141 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVL--KLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 + YIH I HRD+K N+LI +D + K+ FGLA+ + TL Y Sbjct: 142 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKV-----QGNGSFMKTFCGTLAY 196 Query: 195 RPPELLLG------------ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 PE++ G +Y +D+W GC++ + T G+T+ I Sbjct: 197 VAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG 256 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + P LK + A D ID LL +DP Sbjct: 257 RGSYHEGP----------------------------LKDFRISEEARDFIDSLLQVDPNN 288 Query: 303 RIDSDDALNHDFFWSDPM 320 R + ALNH + P+ Sbjct: 289 RSTAAKALNHPWIKMSPL 306 >6FDY-U nrPDB Length = 276 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 73/312 (23%), Positives = 123/312 (39%), Gaps = 46/312 (14%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKILQL 72 + + ++G GT+ V+KA +K T + VA+K V ++ + L EI+IL+ Sbjct: 8 PRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKG 67 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 ++H ++V L + + +IYL+ +FC + + MQ Sbjct: 68 IRHPHIVQLKD--------FQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 119 Query: 133 LLNGLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L + L ++H I H D+K N+L++ LKLADFG A+ S R Sbjct: 120 LASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR-----G 174 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PE++ +R Y +DLW G I+ E P + I Sbjct: 175 SPLYMAPEMV-CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI--------- 224 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + +V + + DL+ +LL DP++RI D Sbjct: 225 --------------------RSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFF 264 Query: 311 NHDFFWSDPMPS 322 H + + MPS Sbjct: 265 AHPWVDLEHMPS 276 >3IS5-A nrPDB Length = 285 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 125/306 (40%), Gaps = 52/306 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + K+G G FG+V R +G + +K + + + EI++L+ L H N+ Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKD-RSQVPMEQIEAEIEVLKSLDHPNI 82 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVK---FTLSEIKRVMQMLL 134 + + E+ ++Y+V + CE +L + + + + + +M+ ++ Sbjct: 83 IKIFEVFED--------YHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMM 134 Query: 135 NGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 N L Y H ++H+D+K N+L +K+ DFGLA F ++S TN T Sbjct: 135 NALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-----TNAAGT 189 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PE+ +RD D+W AG +M + T G + + Sbjct: 190 ALYMAPEVF--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEE--------------- 232 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 K ++ ++ P A+DL+ ++L DP +R + L+ Sbjct: 233 --------------VQQKATYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLH 278 Query: 312 HDFFWS 317 H++F Sbjct: 279 HEWFKQ 284 >5JZN-A nrPDB Length = 280 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 115/305 (37%), Gaps = 51/305 (16%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +Y+ IG G F V + R T ++ ALK + + G E+ IL+ +KH Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCR-GKEHMIQNEVSILRRVKH 76 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+V LIE +YLV + + K+T + ++ L + Sbjct: 77 PNIVLLIE--------EMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLAS 128 Query: 136 GLYYIHRNKILHRDMKAANVLI----TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + Y+H I+HRD+K N+L+ LKL DFGLA T Sbjct: 129 AIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP-------LYTVCGT 181 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG--SIT 249 Y PE++ E YG +D+W AG I + P +G+ + ++ L G Sbjct: 182 PTYVAPEII-AETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFP 240 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 W NV + A +LI +L++D QR + Sbjct: 241 SPYWDNVSDS----------------------------AKELITMMLLVDVDQRFSAVQV 272 Query: 310 LNHDF 314 L H + Sbjct: 273 LEHPW 277 >6CKI-A nrPDB Length = 316 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 115/308 (37%), Gaps = 35/308 (11%) Query: 19 YEKLA-KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HE 76 Y+ +G+G V + T Q+ A+K + E + RE+++L + H Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQCQGHR 71 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 NV + + + YLVF+ + F E V+Q + + Sbjct: 72 NV--------LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASA 123 Query: 137 LYYIHRNKILHRDMKAANVLITRDGV---LKLADFGLARAFSLAKNSQP---NRYTNRVV 190 L ++H I HRD+K N+L +K+ DFGL L + P Sbjct: 124 LDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCG 183 Query: 191 TLWYRPPELLLGERD----YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + Y PE++ + Y DLW G I+ + + P G CG Sbjct: 184 SAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD--------CG 235 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 E P N E ++ K + D+ A++ A DLI KLLV D QR+ + Sbjct: 236 WDRGEACPACQNM----LFESIQEGKYEFPDKDWAHI-SCAAKDLISKLLVRDAKQRLSA 290 Query: 307 DDALNHDF 314 L H + Sbjct: 291 AQVLQHPW 298 >2A27-A nrPDB Length = 321 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 112/306 (36%), Gaps = 50/306 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP----ITALREIKILQLLK 74 Y+ ++G G F V K R + TG + A K + + RE+ IL+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H NV+ L ++ + + L+ + + E ++ +L Sbjct: 74 HHNVITLHDVYENRTD--------VVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDG----VLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H KI H D+K N+++ +KL DFGLA + N Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG-----VEFKNIFG 180 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T + PE++ G D+W G I + + + G+T+Q LA I+ + Sbjct: 181 TPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDE 239 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E + A D I KLLV + +R+ +AL Sbjct: 240 EFFSQ----------------------------TSELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 311 NHDFFW 316 H + Sbjct: 272 RHPWIT 277 >2WO6-A nrPDB Length = 382 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 87/343 (25%), Positives = 140/343 (40%), Gaps = 50/343 (14%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + +YE + IG+G+FG+V KA R + VA+K + K+ F A E+++L+L+ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKII---KNKKAFLNQAQIEVRLLELMNK 109 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQMLL 134 + I K R + LVF+ ++L LL N + +L+ ++ Q + Sbjct: 110 HDTEMKYYIVHLKRHFMFR--NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 135 NGLYYIH--RNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L ++ I+H D+K N+L+ + +K+ DFG + R + Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL-------GQRIYQYIQ 220 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + +YR PE+LLG Y ID+W GCI+ EM T P+ G E Q+ I ++ G Sbjct: 221 SRFYRSPEVLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 279 Query: 251 EVWPNVDN-YELYEKLELVKGQKRKVKDRLKAY--------------------------- 282 + + +EKL +K KD + Y Sbjct: 280 HILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGES 339 Query: 283 ----VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMP 321 DLI ++L DP RI AL H FF Sbjct: 340 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >1FOT-A nrPDB Length = 318 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 68/345 (19%), Positives = 125/345 (36%), Gaps = 61/345 (17%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLK 74 + ++ L +G G+FG V R R G+ A+K + E + E +L ++ Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H ++ + + I+++ D+ E L +F K + Sbjct: 65 HPFIIRMWGTFQD--------AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVC 116 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 L Y+H I++RD+K N+L+ ++G +K+ DFG A+ P+ T Y Sbjct: 117 LALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV-------PDVTYTLCGTPDY 169 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ + Y ID W G ++ EM + I P Sbjct: 170 IAPEVV-STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPP---- 224 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDA 309 + DL+ +L+ D +QR+ ++D Sbjct: 225 ----------------------------FFNEDVKDLLSRLITRDLSQRLGNLQNGTEDV 256 Query: 310 LNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQST 354 NH +F + +LS ++ + +E PP ++G T Q Sbjct: 257 KNHPWFKE----VVWEKLLSRNIETPYE---PPIQQGQGDTSQFD 294 >5XVU-A nrPDB Length = 332 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 83/322 (25%), Positives = 150/322 (46%), Gaps = 28/322 (8%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 YD++E + ++ ++YE + KIG+G + EVF + + A ++ K Sbjct: 19 DYDNLELQW-NKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKKI 72 Query: 64 LREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 REIKILQ L N++ L++I + + L+F++ + L KFT Sbjct: 73 KREIKILQNLNGGPNIIKLLDIVKDPVTKTPS------LIFEYINNIDFKTLY---PKFT 123 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQ 181 +I+ + +L L Y H I+HRD+K N++I + ++L +GLA + Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPG---- 179 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMA-EMWTRSPIMQGNTEQHQLAL 240 Y RV + +Y+ PELL+ + Y +D+W GC++A ++ + P G+ QL Sbjct: 180 -QEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVK 238 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD-----PYALDLIDKL 295 I+++ G+ + N +L + G+ + + +DLIDK+ Sbjct: 239 IAKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKM 298 Query: 296 LVLDPAQRIDSDDALNHDFFWS 317 L+ D A+RI +A+ H +F Sbjct: 299 LIYDHAKRIAPKEAMEHPYFRE 320 >1ZWS-A nrPDB Length = 288 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 112/306 (36%), Gaps = 50/306 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP----ITALREIKILQLLK 74 Y+ ++G G F V K R + TG + A K + + RE+ IL+ + Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 H NV+ L ++ + + L+ + + E ++ +L Sbjct: 74 HHNVITLHDVYENRTD--------VVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 125 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDG----VLKLADFGLARAFSLAKNSQPNRYTNRVV 190 +G+ Y+H KI H D+K N+++ +KL DFGLA + N Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG-----VEFKNIFG 180 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T + PE++ G D+W G I + + + G+T+Q LA I+ + Sbjct: 181 TPEFVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDE 239 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E + A D I KLLV + +R+ +AL Sbjct: 240 EFFS----------------------------HTSELAKDFIRKLLVKETRKRLTIQEAL 271 Query: 311 NHDFFW 316 H + Sbjct: 272 RHPWIT 277 >5LOH-A nrPDB Length = 341 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 74/367 (20%), Positives = 126/367 (34%), Gaps = 58/367 (15%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFP 60 + + + P + ++ + I +G FG+V+ + K G+ A+K V + + Sbjct: 21 EEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMT 78 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 E L L K +V+L ++ ++YLV ++ L ++ Sbjct: 79 HQVQAERDALALSKSPFIVHLYYSLQS--------ANNVYLVMEYLIGGDVKSLLHIYGY 130 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 F + + + L Y+HR+ I+HRD+K N+LI+ +G +KL DFGL++ + Sbjct: 131 FDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDIN 190 Query: 181 QPNRYTNR--VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 + T R T Y PELLLG R +GP +D W G + E T P T Q Sbjct: 191 MMDILTTRTFCGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVF 249 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 I + R + A ++ LL + Sbjct: 250 QNILK-----------------------------RDIPWPEGEEKLSDNAQSAVEILLTI 280 Query: 299 DPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSR 358 D +R + H F Q ++ Sbjct: 281 DDTKRAGMKELKRHPLFSD---------------VDWENLQHQTMPFIPQPDDETDTSYF 325 Query: 359 NPATTNQ 365 T Q Sbjct: 326 EARNTAQ 332 >1KOB-A nrPDB Length = 387 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 65/346 (18%), Positives = 124/346 (35%), Gaps = 48/346 (13%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITAL 64 VE Y+ L ++G G FG V + + TG+ K + + + T Sbjct: 39 PQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY--TVK 96 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTL 123 EI I+ L H ++NL + K + L+ +F +L ++ K + Sbjct: 97 NEISIMNQLHHPKLINLHDAFEDKYE--------MVLILEFLSGGELFDRIAAEDYKMSE 148 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI--TRDGVLKLADFGLARAFSLAKNSQ 181 +E+ M+ GL ++H + I+H D+K N++ + +K+ DFGLA + + + Sbjct: 149 AEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVK 208 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI 241 T + PE++ G D+W G + + + G + L + Sbjct: 209 VTT-----ATAEFAAPEIV-DREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNV 262 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 + + + +V P A D I LL +P Sbjct: 263 KRCDWEFDEDAFSSV----------------------------SPEAKDFIKNLLQKEPR 294 Query: 302 QRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGS 347 +R+ DAL H + D + + S+ + + + Sbjct: 295 KRLTVHDALEHPWLKGDHS-NLTSRIPSSRYNKIRQKIKEKYADWP 339 >4RLP-A nrPDB Length = 288 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 119/309 (38%), Gaps = 55/309 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMENEKEGFPITA--LREIKILQLL 73 +E L +G+G +G+VF+ R TG+ A+K + TA E IL+ + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 66 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 KH +V+LI +T G +YL+ ++ + F + + Sbjct: 67 KHPFIVDLIYAFQTG--------GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 118 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L ++H+ I++RD+K N+++ G +KL DFGL + T+ Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE----SIHDGTVTHTFCGTIE 174 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L+ + +D W G +M +M T +P G + + I + ++ P + Sbjct: 175 YMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYL- 232 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDD 308 A DL+ KLL + A R+ D+ + Sbjct: 233 -------------------------------TQEARDLLKKLLKRNAASRLGAGPGDAGE 261 Query: 309 ALNHDFFWS 317 H FF Sbjct: 262 VQAHPFFRH 270 >2Z7Q-A nrPDB Length = 321 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 77/353 (21%), Positives = 129/353 (36%), Gaps = 66/353 (18%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + S +E L +GQG+FG+VF R +G A+K + K + E IL Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILA 85 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 + H VV L +T +G +YL+ DF + V FT ++K + Sbjct: 86 DVNHPFVVKLHYAFQT--------EGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 137 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L GL ++H I++RD+K N+L+ +G +KL DFGL++ + + T Sbjct: 138 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE----AIDHEKKAYSFCGT 193 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + Y PE++ + + D W G +M EM T S QG + + LI + + Sbjct: 194 VEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ- 251 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DS 306 A L+ L +PA R+ + Sbjct: 252 -------------------------------FLSTEAQSLLRALFKRNPANRLGSGPDGA 280 Query: 307 DDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRN 359 ++ H F + L + PP + + Q + Sbjct: 281 EEIKRHVF---------YSTIDWNKLY--RREIKPPFK--PAVAQPDDTFYFD 320 >6FYV-A nrPDB Length = 337 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 140/337 (41%), Gaps = 58/337 (17%) Query: 18 KYEKLAKIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKILQLLKH- 75 +YE + +G+G FG+V + G VA+K V + A EI++L+ L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIV---KNVGRYREAARSEIQVLEHLNST 71 Query: 76 -EN----VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRV 129 N V ++E G + +VF+ + N + F + I+++ Sbjct: 72 DPNSVFRCVQMLEWFDH--------HGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQM 123 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR-------------------DGVLKLADFGL 170 + + ++H NK+ H D+K N+L + + +K+ DFG Sbjct: 124 AYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGS 183 Query: 171 ARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQ 230 A ++ V T YR PE++L + P D+W GCI+ E + + Q Sbjct: 184 AT-------YDDEHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQ 235 Query: 231 GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL-----------VKGQKRKVKDRL 279 + + LA++ ++ G I + + + +L V+ + + +K+ + Sbjct: 236 THDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFM 295 Query: 280 KAYVRDPYAL-DLIDKLLVLDPAQRIDSDDALNHDFF 315 + + L DL+ ++L DP QRI D+AL H FF Sbjct: 296 LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >5F9E-A nrPDB Length = 353 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 73/354 (20%), Positives = 137/354 (38%), Gaps = 61/354 (17%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLL 73 ++ +E +G+G+FG+VF A +KT Q A+K + + + + E ++L L Sbjct: 17 KIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLA 76 Query: 74 -KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 +H + ++ +TK +++ V ++ KF LS Sbjct: 77 WEHPFLTHMFCTFQTKE--------NLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 128 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 ++ GL ++H I++RD+K N+L+ +DG +K+ADFG+ + L + T Sbjct: 129 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGD----AKTNEFCGTP 184 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE+LLG++ Y +D W G ++ EM G E+ I Sbjct: 185 DYIAPEILLGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI----------- 232 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD-DALN 311 ++ + + A DL+ KL V +P +R+ D Sbjct: 233 ---------------------RMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQ 271 Query: 312 HDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365 H F + + L + + PP R ++ + + N+ Sbjct: 272 HPLF---------REINWEELE--RKEIDPPFR--PKVKSPFDCSNFDKEFLNE 312 >4AN9-A nrPDB Length = 301 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 119/318 (37%), Gaps = 48/318 (15%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +EK++++G G G VFK H+ +G +A K + +E K +RE+++L Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 67 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V + G I + + + + + + +V ++ G Sbjct: 68 YIVGFYGAFYSD--------GEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 119 Query: 137 LYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L Y+ ++KI+HRD+K +N+L+ G +KL DFG++ V T Y Sbjct: 120 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DEMANEFVGTRSYM 173 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE L G Y D+W G + EM Sbjct: 174 SPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYP--------------------------- 205 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 EL+ + +L + V D ++K L+ +PA+R D + H F Sbjct: 206 ---RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 262 Query: 316 W-SDPMPSDLKGMLSTHL 332 SD D G L + + Sbjct: 263 KRSDAEEVDFAGWLCSTI 280 >4QMW-A nrPDB Length = 310 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 123/306 (40%), Gaps = 46/306 (15%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 D + KL KIG+G+FGEVFK +T + VA+K + + E E +EI +L Sbjct: 25 ADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDL-EEAEDEIEDIQQEITVLSQ 83 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 V ++++ ++ A L ++I +++ Sbjct: 84 CDSPYVTKYYGSYLKDT--------KLWIIMEYLGGGSALDLLE-PGPLDETQIATILRE 134 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +L GL Y+H K +HRD+KAANVL++ G +KLADFG+A + + V T Sbjct: 135 ILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLT----DTQIKRNTFVGTP 190 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 ++ PE++ + Y D+W G E+ P ++E H + ++ + Sbjct: 191 FWMAPEVI-KQSAYDSKADIWSLGITAIELARGEPP---HSELHPMKVLFLI-------- 238 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 + L+ P + ++ L +P+ R + + L H Sbjct: 239 -------------------PKNNPPTLEGNYSKPL-KEFVEACLNKEPSFRPTAKELLKH 278 Query: 313 DFFWSD 318 F + Sbjct: 279 KFILRN 284 >3HKO-A nrPDB Length = 345 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 121/346 (34%), Gaps = 82/346 (23%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR---EIKILQLLK 74 KY IGQG++G V A +T A+K + ++ P R E+++++ L Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLH 86 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFC---------------------------- 106 H N+ L E+ + I LV + C Sbjct: 87 HPNIARLYEVYED--------EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQ 138 Query: 107 ------------EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 + G ++ I +M+ + + L+Y+H I HRD+K N Sbjct: 139 ICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPEN 198 Query: 155 VLI--TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL-GERDYGPPID 211 L + +KL DFGL++ F N + T + T ++ PE+L YGP D Sbjct: 199 FLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCD 258 Query: 212 LWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQ 271 W AG ++ + + G + ++ + Sbjct: 259 AWSAGVLLHLLLMGAVPFPGVNDADTISQVL----------------------------N 290 Query: 272 KRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 K+ + V P A DL+ LL + +R D+ AL H + Sbjct: 291 KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQ 336 >6EII-A nrPDB Length = 352 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 86/322 (26%), Positives = 153/322 (47%), Gaps = 28/322 (8%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 Y+S + ++ Y+ + K+G+G + EVF+A + +K V+++ K Sbjct: 48 DYESHVVEWGNQ-DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKI 101 Query: 64 LREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 REIKIL+ L+ N++ L +I + S LVF+ + L L + Sbjct: 102 KREIKILENLRGGPNIITLADIVKDPVSRTPA------LVFEHVNNTDFKQLYQTLTDY- 154 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQ 181 +I+ M +L L Y H I+HRD+K NV+I L+L D+GLA + Sbjct: 155 --DIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG---- 208 Query: 182 PNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLAL 240 Y RV + +++ PELL+ + Y +D+W GC++A M + + P G+ QL Sbjct: 209 -QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVR 267 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR-----LKAYVRDPYALDLIDKL 295 I+++ G+ + + N EL + + G+ + + ++ P ALD +DKL Sbjct: 268 IAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKL 327 Query: 296 LVLDPAQRIDSDDALNHDFFWS 317 L D R+ + +A+ H +F++ Sbjct: 328 LRYDHQSRLTAREAMEHPYFYT 349 >2X4F-A nrPDB Length = 373 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 121/307 (39%), Gaps = 47/307 (15%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 +G G FG+V K TG K+A K + K+ EI ++ L H N++ L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDK--EEVKNEISVMNQLDHANLIQLY 152 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIH 141 + + K I LV ++ + +L + + T + M+ + G+ ++H Sbjct: 153 DAFES--------KNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMH 204 Query: 142 RNKILHRDMKAANVL-ITRDG-VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + ILH D+K N+L + RD +K+ DFGLAR + + + N T + PE+ Sbjct: 205 QMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVN-----FGTPEFLAPEV 259 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNY 259 + + P D+W G I + + G+ + L I + E + ++ Sbjct: 260 VNYDFV-SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDI--- 315 Query: 260 ELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDP 319 A + I KLL+ + + RI + +AL H + Sbjct: 316 -------------------------SEEAKEFISKLLIKEKSWRISASEALKHPWLSDHK 350 Query: 320 MPSDLKG 326 + S L Sbjct: 351 LHSRLSA 357 >2XIK-A nrPDB Length = 294 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 69/313 (22%), Positives = 118/313 (37%), Gaps = 50/313 (15%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 D + KL +IG+G+FGEV+K T + VA+K + + E E +EI +L Sbjct: 16 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDL-EEAEDEIEDIQQEITVLSQC 74 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQ 131 + ++++ ++ G ++L L E I +++ Sbjct: 75 DSPYITRYFGSYLKST--------KLWIIMEYLG---GGSALDLLKPGPLEETYIATILR 123 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +L GL Y+H + +HRD+KAANVL++ G +KLADFG+A + + V T Sbjct: 124 EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLT----DTQIKRNTFVGT 179 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PE++ + Y D+W G E+ P L LI Sbjct: 180 PFWMAPEVI-KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI---------- 228 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + L+ P + ++ L DP R + + L Sbjct: 229 --------------------PKNSPPTLEGQHSKP-FKEFVEACLNKDPRFRPTAKELLK 267 Query: 312 HDFFWSDPMPSDL 324 H F + Sbjct: 268 HKFITRYTKKTSF 280 >6CMJ-A nrPDB Length = 321 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 75/331 (22%), Positives = 126/331 (38%), Gaps = 55/331 (16%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN---------EKEG 58 C ++ +Y +IG+G++G V A + A+K + + + G Sbjct: 25 TGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRG 84 Query: 59 FPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL 118 +EI IL+ L H NVV L+E+ +Y+VF+ + L Sbjct: 85 PIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE------DHLYMVFELVNQGPVMEVPT-L 137 Query: 119 VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + + Q L+ G+ Y+H KI+HRD+K +N+L+ DG +K+ADFG++ F Sbjct: 138 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--- 194 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDY--GPPIDLWGAGCIMAEMWTRSPIMQGNTEQH 236 +N V T + PE L R G +D+W G + Sbjct: 195 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------- 246 Query: 237 QLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLL 296 I L I + D ++ E L DLI ++L Sbjct: 247 MDERIMCLHSKIKSQALEFPDQPDIAEDL-----------------------KDLITRML 283 Query: 297 VLDPAQRIDSDDALNHDFFWS---DPMPSDL 324 +P RI + H + +P+PS+ Sbjct: 284 DKNPESRIVVPEIKLHPWVTRHGAEPLPSED 314 >6ED6-A nrPDB Length = 415 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 76/363 (20%), Positives = 125/363 (34%), Gaps = 63/363 (17%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-ENEKEGFPITALREIKILQLL 73 + Y+ + IG+G FGEV RH+ + + A+K + E K E I+ Sbjct: 86 KAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 145 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM 132 VV L + +Y+V ++ DL L+SN V K Sbjct: 146 NSPWVVQLFYAFQDDR--------YLYMVMEYMPGGDLVNLMSNYDV--PEKWAKFYTAE 195 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 ++ L IH ++HRD+K N+L+ + G LKLADFG V T Sbjct: 196 VVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGM---VHCDTAVGTP 252 Query: 193 WYRPPELLL---GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 Y PE+L G+ YG D W G + EM ++ + I S+ Sbjct: 253 DYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLC 312 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI---DS 306 + + A +LI L D R+ Sbjct: 313 FPEDAEISKH----------------------------AKNLICAFLT-DREVRLGRNGV 343 Query: 307 DDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQT 366 ++ H FF +D H ++ E AP +++ + + + ++ Sbjct: 344 EEIRQHPFFKNDQW----------HWDNIRETAAP---VVPELSSDIDSSNFDDIEDDKG 390 Query: 367 EFE 369 + E Sbjct: 391 DVE 393 >3TXO-A nrPDB Length = 353 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 67/355 (18%), Positives = 122/355 (34%), Gaps = 66/355 (18%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALREIKILQLLK 74 + +E + +G+G+FG+V AR ++TG A+K + + ++ + E +IL L + Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 75 -HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H + L +T ++ V +F +F + + + Sbjct: 82 NHPFLTQLFCCFQTP--------DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEI 133 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 ++ L ++H I++RD+K NVL+ +G KLADFG+ + T Sbjct: 134 ISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE----GICNGVTTATFCGTPD 189 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L E YGP +D W G ++ EM + E I Sbjct: 190 YIAPEIL-QEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN---------- 238 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-DSDD---- 308 + + A ++ + +P R+ Sbjct: 239 ----------------------DEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEH 276 Query: 309 -ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPAT 362 L H FF D + + PP R +I + + +P Sbjct: 277 AILRHPFFKE----IDWAQLN-------HRQIEPPFR--PRIKSREDVSNFDPDF 318 >4FZF-B nrPDB Length = 283 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 122/303 (40%), Gaps = 46/303 (15%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 D + KL +IG+G+FGEVFK +T Q VA+K + + E E +EI +L Sbjct: 4 ADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDL-EEAEDEIEDIQQEITVLSQ 62 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 V + ++++ ++ A L F +I +++ Sbjct: 63 CDSSYVTKYYGSYLKGS--------KLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKE 113 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +L GL Y+H K +HRD+KAANVL++ G +KLA FG+A + + V T Sbjct: 114 ILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLT----DTQIKRNTFVGTP 169 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 ++ PE++ + Y D+W G E+ P N++ H + ++ + + P + Sbjct: 170 FWMAPEVI-QQSAYDSKADIWSLGITAIELAKGEPP---NSDMHPMRVLFLIPKNNPPTL 225 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 + + ID L DP+ R + + L H Sbjct: 226 VGDFTKS----------------------------FKEFIDACLNKDPSFRPTAKELLKH 257 Query: 313 DFF 315 F Sbjct: 258 KFI 260 >6E9W-A nrPDB Length = 443 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 74/312 (23%), Positives = 111/312 (35%), Gaps = 50/312 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-ENEKEGFPITALREIKILQLL 73 + YE + IG+G FGEV RH+ T + A+K + E K E I+ Sbjct: 100 KAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA 159 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM 132 VV L + +Y+V ++ DL L+SN V + Sbjct: 160 NSPWVVQLFYAFQDDR--------YLYMVMEYMPGGDLVNLMSNYDV--PEKWARFYTAE 209 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 ++ L IH +HRD+K N+L+ + G LKLADFG + R V T Sbjct: 210 VVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGM---VRCDTAVGTP 266 Query: 193 WYRPPELLL---GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 Y PE+L G+ YG D W G + EM ++ + I S+T Sbjct: 267 DYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLT 326 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI---DS 306 ++ A +LI L D R+ Sbjct: 327 FPDDNDISK----------------------------EAKNLICAFLT-DREVRLGRNGV 357 Query: 307 DDALNHDFFWSD 318 ++ H FF +D Sbjct: 358 EEIKRHLFFKND 369 >1VZO-A nrPDB Length = 355 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 131/314 (41%), Gaps = 51/314 (16%) Query: 16 VSKYEKLAKIGQGTFGEVFKARH---RKTGQKVALKKVLMEN--EKEGFPITALREIKIL 70 + +E L +G G +G+VF R TG+ A+K + +K E ++L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 71 QLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 + ++ +V L +T+ ++L+ D+ + +FT E++ Sbjct: 113 EHIRQSPFLVTLHYAFQTET--------KLHLILDYINGGELFTHLSQRERFTEHEVQIY 164 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + ++ L ++H+ I++RD+K N+L+ +G + L DFGL++ F + R + Sbjct: 165 VGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADE---TERAYDFC 221 Query: 190 VTLWYRPPELLL-GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 T+ Y P+++ G+ + +D W G +M E+ T + + E++ A IS+ Sbjct: 222 GTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKS 281 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI---- 304 P + A DLI +LL+ DP +R+ Sbjct: 282 EPPYPQEM----------------------------SALAKDLIQRLLMKDPKKRLGCGP 313 Query: 305 -DSDDALNHDFFWS 317 D+D+ H FF Sbjct: 314 RDADEIKEHLFFQK 327 >3HDN-A nrPDB Length = 373 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 70/357 (19%), Positives = 126/357 (35%), Gaps = 64/357 (17%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKIL-QL 72 + S + L IG+G+FG+V ARH+ A+K + + K+ + E +L + Sbjct: 36 KPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 95 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 +KH +V L +T +Y V D+ F + Sbjct: 96 VKHPFLVGLHFSFQT--------ADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAE 147 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + + L Y+H I++RD+K N+L+ G + L DFGL + + + T Sbjct: 148 IASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKE----NIEHNSTTSTFCGTP 203 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE+L ++ Y +D W G ++ EM P I ++ Sbjct: 204 EYLAPEVLH-KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK----PLQL 258 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD----D 308 PN+ N A L++ LL D +R+ + + Sbjct: 259 KPNITNS----------------------------ARHLLEGLLQKDRTKRLGAKDDFME 290 Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365 +H FF L + + + PP ++ + + +P T + Sbjct: 291 IKSHVFF-------SLINWDD----LINKKITPPFN--PNVSGPNDLRHFDPEFTEE 334 >4CSV-A nrPDB Length = 275 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 121/288 (42%), Gaps = 29/288 (10%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D E P S+ K+G G FGEV++ + R +VA+K + E L+ Sbjct: 4 DKWEIP----RSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTL---KEGTMSVEEFLQ 56 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLS 124 E +I++ LKH N+V L +C + IY++ ++ H L L + + Sbjct: 57 EAQIMKKLKHPNLVQLYGVCT--------KEPPIYIITEYMSHGSLLDYLRDCEGHTVNA 108 Query: 125 E-IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 + + + + +G+ Y+ +HRD+ A N L+ + V+K+ADFGLAR ++ Sbjct: 109 QALLDMAAQVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLI--NEDEYTA 166 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W PE + R + D+W G ++ E++T G + + + Sbjct: 167 RAGAKFPIKWT-APEAISYNR-FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVE 224 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 + P+ P E EL+ K + + +AL+ Sbjct: 225 RGYRMPRPQGCPE-------EIYELMLQCWNKSPEERPTFAETLHALE 265 >1S9I-A nrPDB Length = 354 Score = 216 bits (551), Expect = 9e-57, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 130/335 (38%), Gaps = 36/335 (10%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +E+++++G G G V K +HR +G +A K + +E K +RE+++L Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 74 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 +V + G I + + + + + + +V +L G Sbjct: 75 YIVGFYGAFYSD--------GEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG 126 Query: 137 LYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L Y+ +++I+HRD+K +N+L+ G +KL DFG++ + + V T Y Sbjct: 127 LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI------DSMANSFVGTRSYM 180 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE L G Y D+W G + E+ + + L I E P+ Sbjct: 181 APERLQGT-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPH 238 Query: 256 -----------------VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 +D+ EL+ + +L V P + ++K L+ Sbjct: 239 SISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIK 298 Query: 299 DPAQRIDSDDALNHDFFW-SDPMPSDLKGMLSTHL 332 +PA+R D NH F S+ D G L L Sbjct: 299 NPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTL 333 >4YNZ-A nrPDB Length = 342 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 124/313 (39%), Gaps = 54/313 (17%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 V Y +G+G G V H T QKVA+K V E E + REI IL+L++H Sbjct: 9 VGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEH 68 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQM 132 +V+ L ++ K +YLV + G L + LVK T E ++ + Sbjct: 69 PHVLKLHDVYENKK--------YLYLVLEHVS---GGELFDYLVKKGRLTPKEARKFFRQ 117 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +++ L + H + I HRD+K N+L+ +++ADFG+A + + Sbjct: 118 IISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASL-----QVGDSLLETSCGSP 172 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE++ GE+ G D+W G I+ + + + + L + + P Sbjct: 173 HYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGV-FHMPHF 231 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNH 312 P P L+ ++ +D A+R+ + H Sbjct: 232 IP-------------------------------PDCQSLLRGMIEVDAARRLTLEHIQKH 260 Query: 313 DFF---WSDPMPS 322 ++ ++P P Sbjct: 261 IWYIGGKNEPEPE 273 >3ORZ-A nrPDB Length = 316 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 72/311 (23%), Positives = 117/311 (37%), Gaps = 56/311 (18%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLLKH 75 ++ +G+G+F V AR T ++ A+K + + KE RE ++ L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQM 132 V L + Y + G L + K F + + Sbjct: 97 PFFVKLYFCFQDDEKLYFG-----------LSYAKNGELLKYIRKIGSFDETCTRFYTAE 145 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 +++ L Y+H I+HRD+K N+L+ D +++ DFG A+ S S+ R + V T Sbjct: 146 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSP--ESKQARANSFVGTA 203 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PELL + DLW GCI+ ++ P + E I +L + Sbjct: 204 QYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKF 262 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD---- 308 + P A DL++KLLVLD +R+ ++ Sbjct: 263 F--------------------------------PKARDLVEKLLVLDATKRLGCEEMEGY 290 Query: 309 --ALNHDFFWS 317 H FF S Sbjct: 291 GPLKAHPFFES 301 >5X3F-B nrPDB Length = 393 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 59/318 (18%), Positives = 114/318 (35%), Gaps = 56/318 (17%) Query: 6 DSVECPFCD--EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPIT 62 E P + ++ +++++ +G G+FG V +H+++G A+K + + K Sbjct: 71 KKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEH 130 Query: 63 ALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT 122 L E +ILQ + +V L + ++Y+V ++ + +F+ Sbjct: 131 TLNEKRILQAVNFPFLVKL--------EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFS 182 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 + ++ Y+H +++RD+K N+LI + G +++ DFG A+ Sbjct: 183 EPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK------- 235 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 R T Y PE++L + Y +D W G ++ EM P + I Sbjct: 236 GRTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 294 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 DL+ LL +D + Sbjct: 295 SGKVRFPSHF--------------------------------SSDLKDLLRNLLQVDLTK 322 Query: 303 RI-----DSDDALNHDFF 315 R +D NH +F Sbjct: 323 RFGNLKNGVNDIKNHKWF 340 >6CQF-A nrPDB Length = 297 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 122/306 (39%), Gaps = 43/306 (14%) Query: 9 ECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIK 68 + D Y+ L ++G GT+GEVFKAR + +G VALK V ME + T +EI Sbjct: 8 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEIL 65 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKR 128 IL+ +H N+V +++ +FC + V + +I Sbjct: 66 ILKTCRHANIVAYHGSY--------LWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISY 117 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 V + +L GL Y+H K +HRD+K AN+LI G ++LADFG++ + R Sbjct: 118 VCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQI----GATLARRLAF 173 Query: 189 VVTLWYRPPEL--LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + T ++ PE+ + + Y D+W G E+ P + L L+++ G Sbjct: 174 IGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTK-SG 232 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 P + + + I L P +R + Sbjct: 233 YQPPRLKEKGKWSAAFH--------------------------NFIKVTLTKSPKKRPSA 266 Query: 307 DDALNH 312 L+H Sbjct: 267 TKMLSH 272 >3RAW-A nrPDB Length = 381 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 80/332 (24%), Positives = 141/332 (42%), Gaps = 46/332 (13%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKILQLLKH 75 +YE + +G+GTFG+V + G+ +VALK + + A EI +L+ +K Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR---NVGKYREAARLEINVLKKIKE 107 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLL 134 ++ + S + G + + F+ + L N + L ++ + L Sbjct: 108 KD--KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLC 165 Query: 135 NGLYYIHRNKILHRDMKAANVLIT-------------------RDGVLKLADFGLARAFS 175 + L ++H N++ H D+K N+L ++ +++ADFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT--- 222 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 +T V T YRPPE++L E + P D+W GCI+ E + + Q + + Sbjct: 223 ----FDHEHHTTIVATRHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTHENR 277 Query: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----RKVKDRLKAY--------V 283 L ++ ++ G I + + + K LV + R VK+ K + Sbjct: 278 EHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSL 337 Query: 284 RDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 DL+ ++L DPAQRI +AL H FF Sbjct: 338 EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >4WB7-A nrPDB Length = 405 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 110/306 (35%), Gaps = 54/306 (17%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLLK 74 + ++E++ +G G+FG V +H++TG A+K + + K L E +ILQ + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 +V L + ++Y+V ++ + +F+ + ++ Sbjct: 155 FPFLVKL--------EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIV 206 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Y+H +++RD+K N+LI + G +++ DFG A+ R T Y Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-------GRTWTLCGTPEY 259 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++L + Y +D W G ++ EM P + I Sbjct: 260 LAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-- 316 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDA 309 DL+ LL +D +R +D Sbjct: 317 ------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 346 Query: 310 LNHDFF 315 NH +F Sbjct: 347 KNHKWF 352 >5N23-A nrPDB Length = 352 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 110/306 (35%), Gaps = 53/306 (17%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLLK 74 + ++E++ +G G+FG V +H++TG A+K + + K L E +I Q + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 +V L + ++Y+V ++ + +F+ + ++ Sbjct: 101 FPFLVKL--------EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIV 152 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Y+H +++RD+K N+LI + G +K+ADFG A+ + T Y Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRV------KGRTPWTLCGTPEY 206 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++L + Y +D W G ++ EM P + I Sbjct: 207 LAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHF-- 263 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDA 309 DL+ LL +D +R +D Sbjct: 264 ------------------------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDI 293 Query: 310 LNHDFF 315 NH +F Sbjct: 294 KNHKWF 299 >4WNO-A nrPDB Length = 287 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 127/319 (39%), Gaps = 56/319 (17%) Query: 13 CDEVSKYEKLAK--IGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKI 69 + V K+E K IG G F VFK RHR +VA+K + +N + + +EIKI Sbjct: 12 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG-KEIKI 70 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 L+ LKHEN+V L + + S+YLV ++C + + + I+ Sbjct: 71 LKELKHENIVALYD--------FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLF 122 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDG---------VLKLADFGLARAFSLAKNS 180 +Q + + +H I+HRD+K N+L++ +K+ADFG AR + Sbjct: 123 LQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMA 182 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 + Y PE+++ + Y DLW G I+ + T Q ++ Q L L Sbjct: 183 -----ATLCGSPMYMAPEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-LRL 235 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 + ++ P + L L++ + Sbjct: 236 FYEKNKTLVPTIPRETSAPLRQLLLALLQR----------------------------NH 267 Query: 301 AQRIDSDDALNHDFFWSDP 319 R+D D+ +H F + P Sbjct: 268 KDRMDFDEFFHHPFLDASP 286 >5YV8-A nrPDB Length = 298 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 121/328 (36%), Gaps = 67/328 (20%) Query: 13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN------------------ 54 C ++++Y +IG+G++G V A + A+K + + Sbjct: 9 CVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRP 68 Query: 55 ------EKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH 108 + G +EI IL+ L H NVV L+E+ +Y+VF+ Sbjct: 69 APGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNE------DHLYMVFELVNQ 122 Query: 109 DLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 168 + L + + + Q L+ G+ Y+H KI+HRD+K +N+L+ DG +K+ADF Sbjct: 123 GPVMEVPT-LKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADF 181 Query: 169 GLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY--GPPIDLWGAGCIMAEMWTRS 226 G++ F +N V T + PE L R G +D+W G + Sbjct: 182 GVSNEFK----GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQ 237 Query: 227 PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP 286 I L I + D ++ E L Sbjct: 238 CPF-------MDERIMCLHSKIKSQALEFPDQPDIAEDL--------------------- 269 Query: 287 YALDLIDKLLVLDPAQRIDSDDALNHDF 314 DLI ++L +P RI + H + Sbjct: 270 --KDLITRMLDKNPESRIVVPEIKLHPW 295 >4C0T-A nrPDB Length = 974 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 74/350 (21%), Positives = 129/350 (36%), Gaps = 49/350 (14%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQL 72 V+ ++ ++G+G++ V A + TG++ A+K + + KE E L Sbjct: 263 RNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNR 322 Query: 73 LKHE-NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQ 131 L + V++L + K S+Y V D+ + L + Sbjct: 323 LSNRLGVISLYFTFQD--------KDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGA 374 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ-----PNRYT 186 +L+ + Y+H N ++HRD+K N+L+ +++ DFG AR + R Sbjct: 375 QILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAK 434 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + V T Y PELL + G P D+W GCI+ +M P + E I++L Sbjct: 435 SFVGTAEYVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQF 493 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + + + DLI K+LVL P++R Sbjct: 494 AFSAGFPTII--------------------------------RDLIKKILVLQPSRRATI 521 Query: 307 DDALNHDFFWSDPMPSDLKGMLS-THLTSMFEYLAPPRRKGSQITQQSTN 355 + H FF S LS ++ A K ++ + Sbjct: 522 PEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMTAKSMMKVPELNKAPIT 571 >6QAU-A nrPDB Length = 280 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 123/313 (39%), Gaps = 54/313 (17%) Query: 18 KYEKLAKIGQGTFGEVFKARHR-KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +Y K +G G F VF+ RHR KT +VA+K + +N + I +EIKIL+ L+HE Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS-QILLGKEIKILKELQHE 70 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 N+V L ++ S++LV ++C + I+ + + Sbjct: 71 NIVALYDV--------QELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAA 122 Query: 137 LYYIHRNKILHRDMKAANVLITRDGV---------LKLADFGLARAFSLAKNSQPNRYTN 187 + +H I+HRD+K N+L++ +K+ADFG AR + + Sbjct: 123 MRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMA-----AD 177 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 + Y PE+++ + Y DLW G ++ + P Q N+ Q L + + S Sbjct: 178 LCGSPMYMAPEVIMSQ-HYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-LRMFYEKNRS 235 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 + P + Y L L+ + R+D + Sbjct: 236 LMPSIPRETSPYLANLLLGLL----------------------------QRNQKDRMDFE 267 Query: 308 DALNHDFFWSDPM 320 +H F P+ Sbjct: 268 AFFSHPFLEQGPV 280 >4APC-A nrPDB Length = 350 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 127/302 (42%), Gaps = 46/302 (15%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + KY +L KIG+G+FG+ + + G++ +K++ + + RE+ +L Sbjct: 19 YFQSMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLA 78 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLS-NVLVKFTLSEIKRV 129 +KH N+V E GS+Y+V D+CE DL ++ V F +I Sbjct: 79 NMKHPNIVQYRESFEEN--------GSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW 130 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + L ++H KILHRD+K+ N+ +T+DG ++L DFG+AR NS + Sbjct: 131 FVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL----NSTVELARACI 186 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T +Y PE+ + Y D+W GC++ E+ T + + ++ + I + GS Sbjct: 187 GTPYYLSPEICEN-KPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKI--ISGSFP 243 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 P + L+ +L +P R + Sbjct: 244 P-----------------------------VSLHYSYDLRSLVSQLFKRNPRDRPSVNSI 274 Query: 310 LN 311 L Sbjct: 275 LE 276 >5DYK-A nrPDB Length = 853 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 122/310 (39%), Gaps = 57/310 (18%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLL 73 E+ + E IG+GTFG V H+ T + ALK V + ++ E +I Sbjct: 537 EMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEN 596 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL---SEIKRVM 130 H ++ L+ + Y + + G L + + K L S+ + + Sbjct: 597 DHPFIIRLVRTFKDSK--------YFYFLTELVT---GGELYDAIRKLGLLSKSQAQFYL 645 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 ++ + Y+H I++RD+K N+L+ + G +KL DFG A+ R V Sbjct: 646 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV-------QGRAYTLVG 698 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE++LG + YG +D+W G + E P+ GN E+ QL + + Sbjct: 699 TPHYMAPEVILG-KGYGCTVDIWALGICLYEFICG-PLPFGNDEEDQLEIFRDIL----- 751 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS---- 306 + YV D +++L+ +LL P RI Sbjct: 752 -----------------------TGQLTFPDYVTDTDSINLMKRLLCRLPQGRIGCSING 788 Query: 307 -DDALNHDFF 315 D +H FF Sbjct: 789 FKDIKDHPFF 798 >4B8L-A nrPDB Length = 286 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 118/301 (39%), Gaps = 50/301 (16%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLK 74 + ++ +G+G FG V+ AR ++ +ALK + EKEG REI+I L+ Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQML 133 H N++ + + IYL+ +F +L L +F M+ L Sbjct: 74 HPNILRMYNYFHDRK--------RIYLMLEFAPRGELYKELQKH-GRFDEQRSATFMEEL 124 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + L+Y H K++HRD+K N+L+ G LK+ADFG + ++ R TL Sbjct: 125 ADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS------VHAPSLRRRTMCGTLD 178 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PPE++ G + + +DLW AG + E P + I + P Sbjct: 179 YLPPEMIEG-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPP--- 234 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + DLI KLL P QR+ + H Sbjct: 235 -----------------------------FLSDGSKDLISKLLRYHPPQRLPLKGVMEHP 265 Query: 314 F 314 + Sbjct: 266 W 266 >4RA4-A nrPDB Length = 355 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 115/309 (37%), Gaps = 50/309 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLL 73 +++ + L +G+G+FG+V A + T + A+K + + ++ + E ++L LL Sbjct: 18 KLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALL 77 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 + + C + +Y V ++ + KF + + Sbjct: 78 DKPPFLTQLHSC-------FQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEI 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 GL+++H+ I++RD+K NV++ +G +K+ADFG+ + + + T Sbjct: 131 SIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTR----TFCGTPD 186 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE++ + YG +D W G ++ EM P G E I + S + Sbjct: 187 YIAPEII-AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSL- 244 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS-----DD 308 A+ + L+ PA+R+ D Sbjct: 245 -------------------------------SKEAVSICKGLMTKHPAKRLGCGPEGERD 273 Query: 309 ALNHDFFWS 317 H FF Sbjct: 274 VREHAFFRR 282 >5UNP-A nrPDB Length = 369 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 77/354 (21%), Positives = 142/354 (40%), Gaps = 58/354 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKAR-HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +YE ++ +G+GTFG V + HR+ G +VALK + E + A EI +L+ + Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKII---KNVEKYKEAARLEINVLEKINE 90 Query: 76 EN------VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKR 128 ++ V + + G + + F+ L N + + + +++ Sbjct: 91 KDPDNKNLCVQMFDWFDY--------HGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 142 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-------------------LKLADFG 169 + L + ++H NK+ H D+K N+L +++ DFG Sbjct: 143 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG 202 Query: 170 LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIM 229 A ++ V T YR PE++L E + P D+W GCI+ E + + Sbjct: 203 SAT-------FDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLF 254 Query: 230 QGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----RKVKDRLKAYVR- 284 Q + + LA++ ++ G I + + + + L + R V++ K R Sbjct: 255 QTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRY 314 Query: 285 -------DPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTH 331 DLI+ +L +PA+R+ +AL H FF K S+ Sbjct: 315 LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSR 368 >3LM0-A nrPDB Length = 327 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 130/322 (40%), Gaps = 54/322 (16%) Query: 6 DSVECPFCDEVSKYEKL--AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITA 63 +++ + + + L ++G+G F V + + TGQ+ A K + + Sbjct: 16 ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEI 75 Query: 64 LREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF- 121 L EI +L+L K V+NL E+ + I L+ ++ + S L + Sbjct: 76 LHEIAVLELAKSCPRVINLHEVYENTSE--------IILILEYAAG--GEIFSLCLPELA 125 Query: 122 ---TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFS 175 + +++ R+++ +L G+YY+H+N I+H D+K N+L++ G +K+ DFG++R Sbjct: 126 EMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI- 184 Query: 176 LAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 + T Y PE+L + D+W G I + T + G Q Sbjct: 185 ----GHACELREIMGTPEYLAPEILNYD-PITTATDMWNIGIIAYMLLTHTSPFVGEDNQ 239 Query: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 ISQ+ + E + +V A D I L Sbjct: 240 ETYLNISQVNVDYSEETFSSVSQ----------------------------LATDFIQSL 271 Query: 296 LVLDPAQRIDSDDALNHDFFWS 317 LV +P +R ++ L+H + Sbjct: 272 LVKNPEKRPTAEICLSHSWLQQ 293 >4AF3-A nrPDB Length = 292 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 121/301 (40%), Gaps = 50/301 (16%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLK 74 + +E +G+G FG V+ AR +K+ VALK + EKEG REI+I L Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQML 133 H N++ L + IYL+ ++ +L L F +M+ L Sbjct: 82 HPNILRLYNYFYDRR--------RIYLILEYAPRGELYKEL-QKSCTFDEQRTATIMEEL 132 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + L Y H K++HRD+K N+L+ G LK+ADFG + ++ R TL Sbjct: 133 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS------VHAPSLRRKTMCGTLD 186 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PPE++ G R + +DLW G + E+ +P + + I ++ V Sbjct: 187 YLPPEMIEG-RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVP 245 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 A DLI KLL +P++R+ H Sbjct: 246 TG--------------------------------AQDLISKLLRHNPSERLPLAQVSAHP 273 Query: 314 F 314 + Sbjct: 274 W 274 >2WTK-C nrPDB Length = 305 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 69/320 (21%), Positives = 136/320 (42%), Gaps = 44/320 (13%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEK--EGFPITALREIKILQLL 73 + KY +G+G++G+V + +T + A+K + + + +EI++L+ L Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQM 132 +H+NV+ L+++ YN K +Y+V ++C + +L +V K F + + Sbjct: 64 RHKNVIQLVDVL------YNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQ 117 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L++GL Y+H I+H+D+K N+L+T G LK++ G+A A R + + Sbjct: 118 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ--GSP 175 Query: 193 WYRPPELLLGERDY-GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++PPE+ G + G +D+W AG + + T +G+ I + +I + Sbjct: 176 AFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGD 235 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 P + DL+ +L +PA+R Sbjct: 236 CGPPLS--------------------------------DLLKGMLEYEPAKRFSIRQIRQ 263 Query: 312 HDFFWSDPMPSDLKGMLSTH 331 H +F P++ + Sbjct: 264 HSWFRKKHPPAEAPVPIPPS 283 >5FET-A nrPDB Length = 847 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 120/310 (38%), Gaps = 57/310 (18%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLL 73 E+ + E IG+GTFG V H+ T + ALK V + ++ E +I Sbjct: 531 EMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEN 590 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL---SEIKRVM 130 H ++ L+ + Y + + G L + + K L + + + Sbjct: 591 DHPFIIRLVRTFKDS--------NCFYFLTELVT---GGELYDAIRKLGLLSKPQAQFYL 639 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 ++ + Y+H I++RD+K N+L+ + G +KL DFG A+ R V Sbjct: 640 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI-------QGRAYTLVG 692 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T Y PE++LG + YG +D+W G + E P+ GN ++ QL + + Sbjct: 693 TPHYMAPEVILG-KGYGCTVDIWALGVCLYEFICG-PLPFGNDQEDQLEIFRDIL----- 745 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS---- 306 + YV D +++L+ +LL P RI Sbjct: 746 -----------------------TGQLTFPDYVSDQDSINLMKRLLCRLPQGRIGCSING 782 Query: 307 -DDALNHDFF 315 D H FF Sbjct: 783 FKDIKEHAFF 792 >3NYO-A nrPDB Length = 576 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 120/307 (39%), Gaps = 50/307 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF-PITALREIKILQLLKHEN 77 + + +G+G FGEV + R TG+ A KK+ + K+ AL E +IL+ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV-LVKFTLSEIKRVMQMLLN 135 VV+L T K ++ LV DL + ++ F + + Sbjct: 246 VVSLAYAYET--------KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL +HR +I++RD+K N+L+ G ++++D GLA + RV T+ Y Sbjct: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-----IKGRVGTVGYM 352 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++ ER Y D W GC++ EM Q ++ + + +L + E Sbjct: 353 APEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDAL 310 P A L +LL DPA+R+ + + Sbjct: 412 F----------------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 Query: 311 NHDFFWS 317 H F Sbjct: 444 EHPLFKK 450 >2BRG-A nrPDB Length = 297 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 124/307 (40%), Gaps = 43/307 (14%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 + PF V ++ + +G+G +GEV A +R T + VA+K V M+ + P +EI Sbjct: 1 MAVPF---VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEI 56 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK 127 I ++L HENVV + R YL ++C + + + Sbjct: 57 CINKMLNHENVVKFYG--------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQ 108 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 R L+ G+ Y+H I HRD+K N+L+ LK++DFGLA F N++ Sbjct: 109 RFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRY--NNRERLLNK 166 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 TL Y PELL + P+D+W G ++ M Sbjct: 167 MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGEL-------------------- 206 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 P P+ E + +K+ + K P A L+ K+LV +P+ RI Sbjct: 207 --PWDQPSDSCQEYSD-----WKEKKTYLNPWKKIDSAPLA--LLHKILVENPSARITIP 257 Query: 308 DALNHDF 314 D + Sbjct: 258 DIKKDRW 264 >4LFI-A nrPDB Length = 374 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 55/353 (15%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVAL---------------- 47 Y++ + YE K+G+G + EVF+ + K+ + Sbjct: 27 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIK 86 Query: 48 --------KKVLMENEKEGFPITALREIKILQLLK----------HENVVNLIEICRTKA 89 K + ++ +L+ ++ H N+++L +I + Sbjct: 87 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 146 Query: 90 SPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRD 149 S LVF++ ++ +L K T EI+ M LL L Y H I+HRD Sbjct: 147 SKTPA------LVFEYVDNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRD 197 Query: 150 MKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP 208 +K NV+I ++ L+L D+GLA + + Y RV + +++ PELL+ R Y Sbjct: 198 VKPHNVMIDHKNKKLRLIDWGLAEFYHVN-----MEYNVRVASRFFKGPELLVDYRMYDY 252 Query: 209 PIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL 267 +DLW G ++A M + R P G + QL I ++ G+ E + L + Sbjct: 253 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 312 Query: 268 V-----KGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 + K R + D K + +DLID LL D +R+ + +A+ H +F Sbjct: 313 MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >1ZXE-A nrPDB Length = 303 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 76/316 (24%), Positives = 132/316 (41%), Gaps = 49/316 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 S +E++A +GQG FG+V KAR+ + A+KK+ EK T L E+ +L L H Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK---LSTILSEVMLLASLNH 61 Query: 76 ENVVNLIEICRTKASPYNRC-----KGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRV 129 + VV + + K ++++ ++CE+ L L+ + + E R+ Sbjct: 62 QYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRL 121 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN---------- 179 + +L L YIH I+HR++K N+ I +K+ DFGLA+ + + Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 + T+ + T Y E+L G Y ID++ G I EM P G + L Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILK 239 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 S++ E P+ D+ ++ + ++ I L+ D Sbjct: 240 K----LRSVSIEFPPDFDDNKMKVEKKI------------------------IRLLIDHD 271 Query: 300 PAQRIDSDDALNHDFF 315 P +R + LN + Sbjct: 272 PNKRPGARTLLNSGWL 287 >3A8W-A nrPDB Length = 345 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 69/366 (18%), Positives = 130/366 (35%), Gaps = 48/366 (13%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT-ALREIKILQLL- 73 + ++ L IG+G++ +V R +KT + A+K V E + I E + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 H +V L +T++ ++ V ++ K + + Sbjct: 68 NHPFLVGLHSCFQTES--------RLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEI 119 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L Y+H I++RD+K NVL+ +G +KL D+G+ + ++ + T Sbjct: 120 SLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT----STFCGTPN 175 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+L GE DYG +D W G +M EM I + Sbjct: 176 YIAPEILRGE-DYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPDQNTE 224 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS------D 307 + L +++ + + A ++ L DP +R+ Sbjct: 225 DYLFQVILEKQIRIPRS-------------LSVKAASVLKSFLNKDPKERLGCHPQTGFA 271 Query: 308 DALNHDFF----WSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATT 363 D H FF W + +++ F + ++ Q + + Sbjct: 272 DIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKI 331 Query: 364 NQTEFE 369 +Q+EFE Sbjct: 332 DQSEFE 337 >3KN6-A nrPDB Length = 325 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 70/328 (21%), Positives = 116/328 (35%), Gaps = 65/328 (19%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 + Y + D +G+G+F K H+K+ Q A+K + + Sbjct: 4 SPFYQHYDLDLKD--------KPLGEGSFSICRKCVHKKSNQAFAVKII-----SKRMEA 50 Query: 62 TALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 +EI L+L + H N+V L E+ + + LV + Sbjct: 51 NTQKEITALKLCEGHPNIVKLHEVFHDQLHTF--------LVMELLNGGELFERIKKKKH 102 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLKLADFGLARAFSLA 177 F+ +E +M+ L++ + ++H ++HRD+K N+L + +K+ DFG AR Sbjct: 103 FSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARL---- 158 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ-- 235 K TL Y PE LL + Y DLW G I+ M + Q + Sbjct: 159 KPPDNQPLKTPCFTLHYAAPE-LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLT 217 Query: 236 -----HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 + I + S E W NV A D Sbjct: 218 CTSAVEIMKKIKKGDFSFEGEAWKNVSQ----------------------------EAKD 249 Query: 291 LIDKLLVLDPAQRIDSDDALNHDFFWSD 318 LI LL +DP +R+ +++ Sbjct: 250 LIQGLLTVDPNKRLKMSGLRYNEWLQDG 277 >4IAN-A nrPDB Length = 358 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 86/332 (25%), Positives = 138/332 (41%), Gaps = 44/332 (13%) Query: 18 KYEKLAKIGQGTFGEVFKARHR-KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +Y GQG F V +AR + Q+VA+K + E T L+E++ L+ L Sbjct: 31 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLNDA 87 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNV--LVKFTLSEIKRVMQMLL 134 + + R Y+ K + LVF+ +L +L V + ++ Q L Sbjct: 88 DPDDKFHCLRLFRHFYH--KQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLF 145 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVL-KLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L + R ILH D+K N+L+ + KL DFG A + T +V+ + Sbjct: 146 LALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND------ITPYLVSRF 199 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 YR PE+++G + Y ID+W GC + E++T + G T H L L L G + ++ Sbjct: 200 YRAPEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMI 258 Query: 254 PN--VDNYELYEKLELVKGQKRKVKDRLKAYVRD-------------------------- 285 + + L + + KV +R K V Sbjct: 259 RKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKV 318 Query: 286 PYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 DL+D++L+LDPA+RI + AL H F Sbjct: 319 HQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >3FXW-A nrPDB Length = 336 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 120/311 (38%), Gaps = 53/311 (17%) Query: 16 VSKYEKLA-KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLL 73 Y+ +G G G+V + HR+TGQK ALK + A +E+ Q Sbjct: 27 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLY-------DSPKARQEVDHHWQAS 79 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRV 129 ++V ++++ + K + ++ + E L S + + FT E + Sbjct: 80 GGPHIVCILDVYEN----MHHGKRCLLIIMECMEG--GELFSRIQERGDQAFTEREAAEI 133 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ + + ++H + I HRD+K N+L T +D VLKL DFG A+ + N Sbjct: 134 MRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE------TTQNALQ 187 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 T +Y PE+L G Y D+W G IM + P NT Q Sbjct: 188 TPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQ----------- 235 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P + + + +V + A LI LL DP +R+ Sbjct: 236 ----AISPGMKRRIRLGQYGFPNPEWSEVSED---------AKQLIRLLLKTDPTERLTI 282 Query: 307 DDALNHDFFWS 317 +NH + Sbjct: 283 TQFMNHPWINQ 293 >3PPZ-A nrPDB Length = 309 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 125/329 (37%), Gaps = 58/329 (17%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 A D ++ P+CD KIG G+FG V +A G VA+K ++ ++ Sbjct: 26 AMDGDDMDIPWCD----LNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVN 79 Query: 62 TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVK 120 LRE+ I++ L+H N+V + ++ +V ++ L LL + Sbjct: 80 EFLREVAIMKRLRHPNIVLFMGAVTQPP--------NLSIVTEYLSRGSLYRLLHKSGAR 131 Query: 121 FTLSEIKR--VMQMLLNGLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 L E +R + + G+ Y+H I+HRD+K+ N+L+ + +K+ DFGL+R Sbjct: 132 EQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL--- 188 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQH 236 K S + T + PE+L E D++ G I+ E+ T Sbjct: 189 -KASTFLSSKSAAGTPEWMAPEVLRDEPS-NEKSDVYSFGVILWELATLQQPW------- 239 Query: 237 QLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLL 296 G++ P ++V K K +P +I+ Sbjct: 240 ---------GNLNPA--------------QVVAAVGFKCKRLEIPRNLNPQVAAIIEGCW 276 Query: 297 VLDPAQRI---DSDDALNHDFFWSDPMPS 322 +P +R D L S P Sbjct: 277 TNEPWKRPSFATIMDLLR-PLIKSAVPPP 304 >3TKU-A nrPDB Length = 433 Score = 204 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 108/309 (34%), Gaps = 48/309 (15%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-ENEKEGFPITALREIKILQLLKH 75 +E + IG+G FGEV + + T + A+K + E K E +L Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 + + L + + +YLV D+ DL LLS K + + ++ Sbjct: 150 QWITALHYAFQD--------ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 201 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 + IH+ +HRD+K NVL+ +G ++LADFG + Q + V T Y Sbjct: 202 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQS---SVAVGTPDY 258 Query: 195 RPPELLL----GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 PE+L G YGP D W G M EM + I Sbjct: 259 ISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM-------- 310 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI---DSD 307 + + + A DLI + L+ +R+ + Sbjct: 311 -------------------NHEERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIE 350 Query: 308 DALNHDFFW 316 D H FF Sbjct: 351 DFKKHAFFE 359 >2H8H-A nrPDB Length = 535 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 123/317 (38%), Gaps = 57/317 (17%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D+ E P E + E K+GQG FGEV+ T +VA+K + P L+ Sbjct: 260 DAWEIP--RESLRLEV--KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFLQ 311 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKF-TL 123 E ++++ L+HE +V L + + IY+V ++ L L K+ L Sbjct: 312 EAQVMKKLRHEKLVQLYAVVSEE---------PIYIVTEYMSKGSLLDFLKGETGKYLRL 362 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + + +G+ Y+ R +HRD++AAN+L+ + V K+ADFGLAR N Sbjct: 363 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTA 420 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W P L G + D+W G ++ E+ T G + L + Sbjct: 421 RQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 478 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + P P DL+ + +P + Sbjct: 479 RGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEE 507 Query: 303 RIDSD--DALNHDFFWS 317 R + A D+F S Sbjct: 508 RPTFEYLQAFLEDYFTS 524 >2WQN-A nrPDB Length = 310 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 121/296 (40%), Gaps = 46/296 (15%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-LMENEKEGFPITALREIKILQLLK 74 ++ + KIG+G F EV++A G VALKKV + + ++EI +L+ L Sbjct: 31 LANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLN 90 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVK---FTLSEIKRVM 130 H NV+ + +V + + DL+ ++ + + + + Sbjct: 91 HPNVIKYYASFIED--------NELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYF 142 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 L + L ++H +++HRD+K ANV IT GV+KL D GL R FS S+ + V Sbjct: 143 VQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS----SKTTAAHSLVG 198 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T +Y PE + E Y D+W GC++ EM G+ Sbjct: 199 TPYYMSPERI-HENGYNFKSDIWSLGCLLYEMAALQSPFYGD------------------ 239 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 ++ Y L +K+E L + L++ + DP +R D Sbjct: 240 ----KMNLYSLCKKIEQCDYPP------LPSDHYSEELRQLVNMCINPDPEKRPDV 285 >5MJB-A nrPDB Length = 305 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 118/289 (40%), Gaps = 29/289 (10%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQ---KVALKKVLMENEKEGFPITALREIKILQLLKHE 76 + IG G FGEV+K R + G+ VA+K + E L E I+ H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTL-KAGYSEKQRRDFLSEASIMGQFDHR 87 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N++ L + + ++ +F E+ L L +FT+ ++ +++ + Sbjct: 88 NIIRLEGVVTKSR--------PVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAA 139 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQPNRYTNRVVTLW 193 G+ Y+ +HRD+ A N+L+ + V K++DFGL+R + + + ++ W Sbjct: 140 GMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW 199 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEV 252 PE + R + D+W G +M E+ + + Q + I Q P Sbjct: 200 T-APEAI-AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMD 257 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P + + + + + + + + + +DK+ + +PA Sbjct: 258 CPAALHQLMLDCWQKDRNSRPRFAEIVNT----------LDKM-IRNPA 295 >4AW2-A nrPDB Length = 437 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 71/328 (21%), Positives = 113/328 (34%), Gaps = 55/328 (16%) Query: 4 QYDSVECPFCDEV-------SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-ENE 55 +Y PF +V +E L IG+G FGEV + + + A+K + E Sbjct: 54 EYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEML 113 Query: 56 KEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLL 114 K E +L + + L + ++YLV D+ DL LL Sbjct: 114 KRAETACFREERDVLVNGDSKWITTLHYAFQDD--------NNLYLVMDYYVGGDLLTLL 165 Query: 115 SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF 174 S + + + ++ + +H+ +HRD+K N+L+ +G ++LADFG Sbjct: 166 SKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL 225 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLL----GERDYGPPIDLWGAGCIMAEMWTRSPIMQ 230 Q + V T Y PE+L G+ YGP D W G M EM Sbjct: 226 MEDGTVQS---SVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFY 282 Query: 231 GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 + I K + + + A D Sbjct: 283 AESLVETYGKIM---------------------------NHKERFQFPTQVTDVSENAKD 315 Query: 291 LIDKLLVLDPAQRI---DSDDALNHDFF 315 LI + L+ R+ +D H FF Sbjct: 316 LIRR-LICSREHRLGQNGIEDFKKHPFF 342 >6F3F-A nrPDB Length = 455 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 123/317 (38%), Gaps = 57/317 (17%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D+ E P E + E K+GQG FGEV+ T +VA+K + P L+ Sbjct: 180 DAWEIP--RESLRLEV--KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFLQ 231 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKF-TL 123 E ++++ L+HE +V L + + IY+V ++ L L K+ L Sbjct: 232 EAQVMKKLRHEKLVQLYAVVSEE---------PIYIVTEYMNKGSLLDFLKGETGKYLRL 282 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + + +G+ Y+ R +HRD++AAN+L+ + V K+ADFGLAR N Sbjct: 283 PQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTA 340 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W P L G + D+W G ++ E+ T G + L + Sbjct: 341 RQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 398 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + P P DL+ + +P + Sbjct: 399 RGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEE 427 Query: 303 RIDSD--DALNHDFFWS 317 R + A D+F S Sbjct: 428 RPTFEYLQAFLEDYFTS 444 >4P5Q-A nrPDB Length = 361 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 117/291 (40%), Gaps = 27/291 (9%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 + + +G G FGEV R + +K VA+K + + E L E I+ Sbjct: 31 DATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKV-GYTEKQRRDFLGEASIMG 89 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVM 130 H N++ L + + +V ++ E L L +FT+ ++ ++ Sbjct: 90 QFDHPNIIRLEGVVTKSK--------PVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGML 141 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + +G+ Y+ +HRD+ A N+LI + V K++DFGL+R + ++ Sbjct: 142 RGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIP 201 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 W PE + R + D+W G ++ E+ + + Q + + + Sbjct: 202 IRWT-SPEAI-AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPP 259 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 P P LY+ + + R + + + V ++DK L+ +P Sbjct: 260 PMDCP----AALYQLMLDCWQKDRNNRPKFEQIVS------ILDK-LIRNP 299 >1NY3-A nrPDB Length = 400 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 123/311 (39%), Gaps = 52/311 (16%) Query: 16 VSKYEKL-AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLL 73 + Y+ +G G G+V + +++T +K ALK + A RE+++ + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 112 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRV 129 + ++V ++++ + + +V + + L S + + FT E + Sbjct: 113 QCPHIVRIVDVYEN----LYAGRKCLLIVMECLDG--GELFSRIQDRGDQAFTEREASEI 166 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ + + Y+H I HRD+K N+L T + +LKL DFG A+ + + N T Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLT 221 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 T +Y PE+L G Y D+W G IM + P N Sbjct: 222 TPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------- 269 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P + + E + +V + +K LI LL +P QR+ Sbjct: 270 ----AISPGMKTRIRMGQYEFPNPEWSEVSEEVKM---------LIRNLLKTEPTQRMTI 316 Query: 307 DDALNHDFFWS 317 + +NH + Sbjct: 317 TEFMNHPWIMQ 327 >3KA0-A nrPDB Length = 320 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 123/311 (39%), Gaps = 52/311 (16%) Query: 16 VSKYEKL-AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLL 73 + Y+ +G G G+V + +++T +K ALK + A RE+++ + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 66 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRV 129 + ++V ++++ + + +V + + L S + + FT E + Sbjct: 67 QCPHIVRIVDVYEN----LYAGRKCLLIVMECLDG--GELFSRIQDRGDQAFTEREASEI 120 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ + + Y+H I HRD+K N+L T + +LKL DFG A+ + + N T Sbjct: 121 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLT 175 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 T +Y PE+L G Y D+W G IM + P N Sbjct: 176 EPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------- 223 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P + + E + +V + +K LI LL +P QR+ Sbjct: 224 ----AISPGMKTRIRMGQYEFPNPEWSEVSEEVKM---------LIRNLLKTEPTQRMTI 270 Query: 307 DDALNHDFFWS 317 + +NH + Sbjct: 271 TEFMNHPWIMQ 281 >3PFQ-A nrPDB Length = 674 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 116/313 (37%), Gaps = 40/313 (12%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLL 73 +++ + L +G+G+FG+V + + T + A+K + + ++ + E ++L L Sbjct: 339 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 398 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 + + C + +Y V ++ + +F + Sbjct: 399 GKPPFLTQLHSC-------FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 451 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 GL+++ I++RD+K NV++ +G +K+ADFG+ + + T Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT----KTFCGTPD 507 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT---- 249 Y PE++ + YG +D W G ++ EM +G E I + + Sbjct: 508 YIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMS 566 Query: 250 ----------------------PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY 287 PE ++ + + ++ K ++++++ K Sbjct: 567 KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASGRN 626 Query: 288 ALDLIDKLLVLDP 300 A + D+ P Sbjct: 627 AENF-DRFFTRHP 638 >6BXI-A nrPDB Length = 333 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 108/306 (35%), Gaps = 42/306 (13%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLLK 74 + +E L IG+G FGEV + + TG A+K + + E + +R E IL Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 VV + + K ++YL+ +F L T E + + + Sbjct: 65 SLWVVKMFYSFQDKL--------NLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETV 116 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA----------------------- 171 + IH+ +HRD+K N+L+ G +KL+DFGL Sbjct: 117 LAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 176 Query: 172 --------RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW 223 R K ++ + V T Y PE+ + + Y D W G IM EM Sbjct: 177 TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFM-QTGYNKLCDWWSLGVIMYEML 235 Query: 224 TRSPIMQGNTEQHQLALISQLCGSIT-PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAY 282 P T Q + ++T P P + + + + R ++ Sbjct: 236 IGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEI 295 Query: 283 VRDPYA 288 + + Sbjct: 296 KSNSFF 301 >6E2O-A nrPDB Length = 295 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 121/310 (39%), Gaps = 48/310 (15%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIE 83 +G+GT+G V+ R ++A+K++ + EI + + LKH+N+V + Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQYLG 86 Query: 84 ICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV--LVKFTLSEIKRVMQMLLNGLYYI 140 G I + + L+ LL + +K I + +L GL Y+ Sbjct: 87 SFSEN--------GFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYL 138 Query: 141 HRNKILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 H N+I+HRD+K NVLI GVLK++DFG ++ + TL Y PE+ Sbjct: 139 HDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTE----TFTGTLQYMAPEI 194 Query: 200 L-LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 + G R YG D+W GC + EM T P + Q A+ + PE+ ++ Sbjct: 195 IDKGPRGYGKAADIWSLGCTIIEMATGKPPFY-ELGEPQAAMFKVGMFKVHPEIPESM-- 251 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSD 318 A I K DP +R ++D L +F Sbjct: 252 --------------------------SAEAKAFILKCFEPDPDKRACANDLLVDEFLKVS 285 Query: 319 PMPSDLKGML 328 + L Sbjct: 286 SKKKKTQPKL 295 >2OZA-A nrPDB Length = 356 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 123/311 (39%), Gaps = 52/311 (16%) Query: 16 VSKYEKL-AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLL 73 + Y+ +G G G+V + +++T +K ALK + A RE+++ + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRV 129 + ++V ++++ + + +V + + L S + + FT E + Sbjct: 69 QCPHIVRIVDVYEN----LYAGRKCLLIVMECLDG--GELFSRIQDRGDQAFTEREASEI 122 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ + + Y+H I HRD+K N+L T + +LKL DFG A+ + + N T Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLT 177 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 T +Y PE+L G Y D+W G IM + P N Sbjct: 178 TPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------- 225 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P + + E + +V + +K LI LL +P QR+ Sbjct: 226 ----AISPGMKTRIRMGQYEFPNPEWSEVSEEVKM---------LIRNLLKTEPTQRMTI 272 Query: 307 DDALNHDFFWS 317 + +NH + Sbjct: 273 TEFMNHPWIMQ 283 >2R2P-A nrPDB Length = 295 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 121/292 (41%), Gaps = 27/292 (9%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 E S IG G FGEV R + G++ VA+K + + E L E I+ Sbjct: 20 EASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV-GYTEKQRRDFLGEASIMG 78 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVM 130 H N+++L + + +V ++ E L L +FT+ ++ ++ Sbjct: 79 QFDHPNIIHLEGVVTKSK--------PVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGML 130 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + G+ Y+ +HRD+ A N+LI + V K++DFGL+R + ++ Sbjct: 131 RGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIP 190 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 W PE + R + D+W G +M E+ + T Q + + + + Sbjct: 191 IRWT-APEAI-AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPS 248 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P P LY+ + ++R + + ++++DK L+ +PA Sbjct: 249 PMDCP----AALYQLMLDCWQKERNSRPKF------DEIVNMLDK-LIRNPA 289 >4XEY-B nrPDB Length = 408 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 62/338 (18%), Positives = 123/338 (36%), Gaps = 55/338 (16%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 ++ YD E E + K+G G +GEV++ +K VA+K + + + Sbjct: 113 VSPNYDKWEM----ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---V 165 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV 119 L+E +++ +KH N+V L+ +C + Y++ +F +L L Sbjct: 166 EEFLKEAAVMKEIKHPNLVQLLGVCT--------REPPFYIITEFMTYGNLLDYLRECNR 217 Query: 120 KFTLSEIKRVMQ-MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + + M + + + Y+ + +HRD+ A N L+ + ++K+ADFGL+R + Sbjct: 218 QEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT--G 275 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQ 237 ++ + W PE L + + D+W G ++ E+ T G Sbjct: 276 DTYTAHAGAKFPIKWT-APESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV 333 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 L+ + PE P +L+ Sbjct: 334 YELLEKDYRMERPEGCP-------------------------------EKVYELMRACWQ 362 Query: 298 LDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSM 335 +P+ R + H F + S + + L Sbjct: 363 WNPSDRPSFAEI--HQAFETMFQESSISDEVEKELGKQ 398 >6BDL-A nrPDB Length = 347 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 114/309 (36%), Gaps = 51/309 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHR-KTGQKVALKKVLMENEKEGFPITALR-EIKILQL 72 ++S + + +G G FG V + + + + A+K + + + +R E +I+Q Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQG 91 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 + +V L + +Y++ + C + F S + Sbjct: 92 AHSDFIVRLYRTFKDSK--------YLYMLMEACLGGELWTILRDRGSFEDSTTRFYTAC 143 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 ++ Y+H I++RD+K N+++ G KL DFG A+ K + T Sbjct: 144 VVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW-----TFCGTP 198 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PE++L + + D W G +M E+ T SP G +I + Sbjct: 199 EYVAPEIILN-KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR--------- 248 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSD 307 +D E +K+ A +LI KL +P++R+ Sbjct: 249 --GIDMIEFPKKIAK-------------------NAANLIKKLCRDNPSERLGNLKNGVK 287 Query: 308 DALNHDFFW 316 D H +F Sbjct: 288 DIQKHKWFE 296 >2VWV-A nrPDB Length = 302 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 60/289 (20%), Positives = 120/289 (41%), Gaps = 29/289 (10%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQLLKHE 76 + IG G FGEV + R + G+K VA+K + E L E I+ +H Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTL-KGGYTERQRREFLSEASIMGQFEHP 77 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLN 135 N++ L + + ++ +F E+ L L +FT+ ++ +++ + + Sbjct: 78 NIIRLEGVVTNSM--------PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIAS 129 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFS--LAKNSQPNRYTNRVVTLW 193 G+ Y+ +HRD+ A N+L+ + V K++DFGL+R + ++ + ++ W Sbjct: 130 GMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW 189 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEV 252 PE + R + D W G +M E+ + + Q + I Q P Sbjct: 190 T-APEAI-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPD 247 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P + + + + + + + + A +DK+ + +PA Sbjct: 248 CPTSLHQLMLDCWQKDRNARPRFPQVVSA----------LDKM-IRNPA 285 >4OLI-A nrPDB Length = 645 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 120/299 (40%), Gaps = 35/299 (11%) Query: 18 KY-EKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 +Y +K+ +G+G FG+V + + TG+ VA+K + + +EI IL+ Sbjct: 353 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD-CGPQHRSGWKQEIDILRT 411 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIKRVM 130 L HE+++ C + S+ LV ++ G L + L + + L+++ Sbjct: 412 LYHEHIIKYKGCCEDQGE------KSLQLVMEYVP---LGSLRDYLPRHSIGLAQLLLFA 462 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q + G+ Y+H +HR++ A NVL+ D ++K+ DFGLA+A R Sbjct: 463 QQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 522 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 WY PE L + Y D+W G + E+ T ++ Q +L G Sbjct: 523 VFWY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG---- 571 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 L L +G++ D+ L+ + + R ++ Sbjct: 572 --IAQGQMTVLRLTELLERGERLPRPDKCPC-----EVYHLMKNCWETEASFRPTFENL 623 Score = 85.8 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 85/286 (29%), Gaps = 61/286 (21%) Query: 36 ARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRC 95 R R +V LK + + + ++ + H ++ + +C Sbjct: 88 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--- 142 Query: 96 KGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 +V ++ EH L L ++ V Q L + L Y+ ++H ++ N Sbjct: 143 -----MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRN 197 Query: 155 VLITRDGV-------LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG-ERDY 206 +L+ R G+ +KL+D G+ R+ + PE L G Sbjct: 198 ILLARLGLAEGTSPFIKLSDPGVG-----LGALSREERVERIP---WLAPECLPGGANSL 249 Query: 207 GPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL 265 +D WG G + E+ + +Q + + + P Sbjct: 250 STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP--------------- 294 Query: 266 ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 P L + L +P QR L Sbjct: 295 ------------------SCPQLATLTSQCLTYEPTQRPSFRTILR 322 >5L6P-A nrPDB Length = 298 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 124/294 (42%), Gaps = 29/294 (9%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 +VS + IG G FGEV + R ++ G++ VA+K + + E L E I+ Sbjct: 17 DVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKV-GYTERQRRDFLSEASIMG 75 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVM 130 H N++ L + + ++ +F E+ L L +FT+ ++ ++ Sbjct: 76 QFDHPNIIRLEGVVTKSR--------PVMILTEFMENCALDSFLRLNDGQFTVIQLVGML 127 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF--SLAKNSQPNRYTNR 188 + + G+ Y+ +HRD+ A N+L+ + V K++DFGL+R + + + + Sbjct: 128 RGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGK 187 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGS 247 + W PE + R + D+W G +M E+ + + Q + + Q Sbjct: 188 IPIRWT-APEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRL 245 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P P L++ + + R ++ + V +DK L+ +PA Sbjct: 246 PPPMDCPT----ALHQLMLDCWVRDRNLRPKFSQIVNT------LDK-LIRNPA 288 >2Y6O-A nrPDB Length = 291 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 56/283 (19%), Positives = 118/283 (41%), Gaps = 19/283 (6%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 + S + IG G FGEV R + G++ VA+K + + L E I+ Sbjct: 12 DASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTL-KAGYTDKQRRDFLSEASIMG 70 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVM 130 H N+++L + + ++ ++ E L L +FT+ ++ ++ Sbjct: 71 QFDHPNIIHLEGVVTKCK--------PVMIITEYMENGSLDAFLRKNDGRFTVIQLVGML 122 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + +G+ Y+ +HRD+ A N+L+ + V K++DFG++R + ++ Sbjct: 123 RGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIP 182 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 W PE + R + D+W G +M E+ + + Q + I + Sbjct: 183 IRWT-APEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPP 240 Query: 250 PEVWP---NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL 289 P P + + ++K + + ++ + L +R+P +L Sbjct: 241 PMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSL 283 >5O2B-A nrPDB Length = 285 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 121/307 (39%), Gaps = 52/307 (16%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 K++ ++G+G F V+K +T +VA ++ + E ++L+ L+H N Sbjct: 19 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPN 76 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL---SEIKRVMQMLL 134 +V + + + K I LV + +G L L +F + ++ + +L Sbjct: 77 IVRFYDSWES----ILKGKKCIVLVTELMT---SGTLKTYLKRFKVMKPKVLRSWCRQIL 129 Query: 135 NGLYYIHRNK--ILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 GL ++H I+HRD+K N+ IT G +K+ D GLA + + + + T Sbjct: 130 KGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM------RTSFAKSVIGT 183 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + PE+ E Y +D++ G M EM T Sbjct: 184 PEFMAPEMY--EEHYDESVDVYAFGMCMLEMATSEYPY---------------------- 219 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 E ++ + +K V DP ++I+ + + ++R+ D LN Sbjct: 220 -------SECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLN 272 Query: 312 HDFFWSD 318 H FF D Sbjct: 273 HAFFAED 279 >2FO0-A nrPDB Length = 495 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 123/337 (36%), Gaps = 55/337 (16%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 ++ YD E E + K+G G +GEV++ +K VA+K + + + Sbjct: 205 VSPNYDKWEM----ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---V 257 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV 119 L+E +++ +KH N+V L+ +C + Y++ +F +L L Sbjct: 258 EEFLKEAAVMKEIKHPNLVQLLGVCT--------REPPFYIITEFMTYGNLLDYLRECNR 309 Query: 120 KFTLSEIKRVMQ-MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + + M + + + Y+ + +HR++ A N L+ + ++K+ADFGL+R + Sbjct: 310 QEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMT--G 367 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQ 237 ++ + W PE L + + D+W G ++ E+ T G Sbjct: 368 DTYTAHAGAKFPIKWT-APESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV 425 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 L+ + PE P +L+ Sbjct: 426 YELLEKDYRMERPEGCP-------------------------------EKVYELMRACWQ 454 Query: 298 LDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTS 334 +P+ R + H F + S + + L Sbjct: 455 WNPSDRPSFAEI--HQAFETMFQESSISDEVEKELGK 489 >2I0E-A nrPDB Length = 353 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 96/242 (39%), Gaps = 13/242 (5%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLL 73 +++ + L +G+G+FG+V + + T + A+K + + ++ + E ++L L Sbjct: 18 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 77 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 + + C + +Y V ++ + +F + Sbjct: 78 GKPPFLTQLHSC-------FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 GL+++ I++RD+K NV++ +G +K+ADFG+ + + T Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTT----KTFCGTPD 186 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE++ + YG +D W G ++ EM +G E I + + + Sbjct: 187 YIAPEII-AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMS 245 Query: 254 PN 255 Sbjct: 246 KE 247 >5SYS-A nrPDB Length = 286 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 123/317 (38%), Gaps = 57/317 (17%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D+ E P E + E K+GQG FGE + T +VA+K + P L+ Sbjct: 11 DAWEIP--RESLRLEV--KLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMS---PEAFLQ 62 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKF-TL 123 E ++++ L+HE +V L + + IY+V ++ L L + K+ L Sbjct: 63 EAQVMKKLRHEKLVQLYAVVSEE---------PIYIVTEYMSKGSLLDFLKGEMGKYLRL 113 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + + +G+ Y+ R +HRD++AAN+L+ + V K+ADFGLAR N Sbjct: 114 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTA 171 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W P L G + D+W G ++ E+ T G + L + Sbjct: 172 RQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 229 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + P P DL+ + DP + Sbjct: 230 RGYRMPCPPECP-------------------------------ESLHDLMCQCWRKDPEE 258 Query: 303 RIDSD--DALNHDFFWS 317 R + A D+F S Sbjct: 259 RPTFEYLQAFLEDYFTS 275 >2DQ7-X nrPDB Length = 283 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 117/283 (41%), Gaps = 25/283 (8%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D E P + + ++G G FGEV+ KVA+K + P + L Sbjct: 2 DVWEIP----RESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMS---PESFLE 53 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVK-FTL 123 E +I++ LKH+ +V L + + IY+V ++ L L + + L Sbjct: 54 EAQIMKKLKHDKLVQLYAVVSEE---------PIYIVTEYMNKGSLLDFLKDGEGRALKL 104 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 + + + G+ YI R +HRD+++AN+L+ + K+ADFGLAR N Sbjct: 105 PNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTA 162 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W P L G + D+W G ++ E+ T G + L + Sbjct: 163 RQGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 220 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 + P+ P + +EL ++R + L++++ D Sbjct: 221 RGYRMPCPQDCP-ISLHELMIHCWKKDPEERPTFEYLQSFLED 262 >3VN9-A nrPDB Length = 340 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 113/314 (35%), Gaps = 53/314 (16%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI-L 70 F + E + ++G+G +G V K RH +GQ +A+K++ L ++ I + Sbjct: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA-TVNSQEQKRLLMDLDISM 104 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIK 127 + + V +G +++ + + L V+ K + Sbjct: 105 RTVDCPFTVTFYGAL--------FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 Query: 128 RVMQMLLNGLYYIHRN-KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ ++ L ++H ++HRD+K +NVLI G +K+ DFG++ + T Sbjct: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDS-----VAKT 211 Query: 187 NRVVTLWYRPPELL---LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 Y PE + L ++ Y D+W G M E+ R P T QL + Sbjct: 212 IDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV 271 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + + +L A +D + L + + Sbjct: 272 E------------------------------EPSPQLPADKFSAEFVDFTSQCLKKNSKE 301 Query: 303 RIDSDDALNHDFFW 316 R + + H FF Sbjct: 302 RPTYPELMQHPFFT 315 >5O2C-A nrPDB Length = 380 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 121/307 (39%), Gaps = 52/307 (16%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 K++ ++G+G F V+K +T +VA ++ + E ++L+ L+H N Sbjct: 28 KFDI--ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPN 85 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL---SEIKRVMQMLL 134 +V + + + K I LV + +G L L +F + ++ + +L Sbjct: 86 IVRFYDSWES----ILKGKKCIVLVTELMT---SGTLKTYLKRFKVMKPKVLRSWCRQIL 138 Query: 135 NGLYYIHRNK--ILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 GL ++H I+HRD+K N+ IT G +K+ D GLA + + + + T Sbjct: 139 KGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLM------RTSFAKSVIGT 192 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + PE+ E Y +D++ G M EM T Sbjct: 193 PEFMAPEMY--EEHYDESVDVYAFGMCMLEMATSEYPY---------------------- 228 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 E ++ + +K V DP ++I+ + + ++R+ D LN Sbjct: 229 -------SECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLN 281 Query: 312 HDFFWSD 318 H FF D Sbjct: 282 HAFFAED 288 >3DKO-A nrPDB Length = 318 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 119/292 (40%), Gaps = 27/292 (9%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 + S + IG G FGEV R + G++ VA+K + + E L E I+ Sbjct: 41 DASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV-GYTEKQRRDFLCEASIMG 99 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVM 130 H NVV+L + + +V +F E+ L L +FT+ ++ ++ Sbjct: 100 QFDHPNVVHLEGVVTRGK--------PVMIVIEFMENGALDAFLRKHDGQFTVIQLVGML 151 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + G+ Y+ +HRD+ A N+L+ + V K++DFGL+R + ++ Sbjct: 152 RGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIP 211 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 W PE + R + D+W G +M E+ + + Q + I + Sbjct: 212 VRWT-APEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPA 269 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P P + + + + + ++ K + ++DK+ + +P Sbjct: 270 PMDCPAGLHQLMLDCWQKERAERPKF----------EQIVGILDKM-IRNPN 310 >6DBM-A nrPDB Length = 318 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 120/299 (40%), Gaps = 35/299 (11%) Query: 18 KY-EKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 +Y +K+ +G+G FG+V + + TG+ VA+K + + +EI IL+ Sbjct: 31 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAD-AGPQHRSGWKQEIDILRT 89 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIKRVM 130 L HE+++ C S+ LV ++ G L + L + + L+++ Sbjct: 90 LYHEHIIKYKGCCEDAG------AASLQLVMEYVP---LGSLRDYLPRHSIGLAQLLLFA 140 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q + G+ Y+H +HRD+ A NVL+ D ++K+ DFGLA+A R Sbjct: 141 QQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 200 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 WY PE L + Y D+W G + E+ T ++ Q +L G Sbjct: 201 VFWY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG---- 249 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 L L +G++ D+ A L+ + + R ++ Sbjct: 250 --IAQGQMTVLRLTELLERGERLPRPDKCPA-----EVYHLMKNCWETEASFRPTFENL 301 >2WTK-B nrPDB Length = 373 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 126/333 (37%), Gaps = 40/333 (12%) Query: 12 FCDEVSKYEKLAKIGQGTF---GEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIK 68 F E YE L IG+G F V AR++ TG+ V ++++ +E E+ Sbjct: 4 FLPEGGCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELH 62 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL--SNVLVKFTLSEI 126 + +L H N+V +++V F + A L ++ + I Sbjct: 63 VSKLFNHPNIVPYRATF--------IADNELWVVTSFMAYGSAKDLICTHFMDGMNELAI 114 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++Q +L L YIH +HR +KA+++LI+ DG + L+ GL S+ + Q R Sbjct: 115 AYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVV 172 Query: 187 NRVV-----TLWYRPPELLLGE-RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 + L + PE+L + Y D++ G E+ + L Sbjct: 173 HDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQML-- 230 Query: 241 ISQLCGSIT--------------PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR-- 284 + +L G++ +V N L + L + Y R Sbjct: 231 LEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTF 290 Query: 285 DPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 P+ +++ L +P R + LNH FF Sbjct: 291 SPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQ 323 >1JPA-A nrPDB Length = 312 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 117/294 (39%), Gaps = 29/294 (9%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 ++S + IG G FGEV + G++ VA+K + E L E I+ Sbjct: 31 DISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTL-KSGYTEKQRRDFLSEASIMG 89 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVM 130 H NV++L + + ++ +F E L L +FT+ ++ ++ Sbjct: 90 QFDHPNVIHLEGVVTKST--------PVMIITEFMENGSLDSFLRQNDGQFTVIQLVGML 141 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA--KNSQPNRYTNR 188 + + G+ Y+ +HRD+ A N+L+ + V K++DFGL+R + + + Sbjct: 142 RGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGK 201 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGS 247 + W PE + R + D+W G +M E+ + T Q + I Q Sbjct: 202 IPIRWT-APEAI-QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRL 259 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P P+ + + + + + + K + +DK+ + +P Sbjct: 260 PPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNT----------LDKM-IRNPN 302 >2X7G-A nrPDB Length = 389 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 74/374 (19%), Positives = 137/374 (36%), Gaps = 88/374 (23%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH- 75 +Y + K+G G F V+ + + VA+K V + + TAL EIK+L+ ++ Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVV---KSAQHYTETALDEIKLLKCVRES 87 Query: 76 ----EN---VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAG-LLSNVLVKFTLSEIK 127 N VV LI+ + + +VF+ H L ++ + + +K Sbjct: 88 DPSDPNKDMVVQLIDDFKISG----MNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVK 143 Query: 128 RVMQMLLNGLYYIHRN-KILHRDMKAANVLITRDG------------------------- 161 +++ +L GL Y+H KI+H D+K N+L+ D Sbjct: 144 SIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSA 203 Query: 162 ----------------------VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 +K+AD G A +T + T YR E+ Sbjct: 204 VSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH-------KHFTEDIQTRQYRSIEV 256 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNT------EQHQLALISQLCGSITPEV- 252 L+G Y P D+W C+ E+ T + + ++ ++ +A I +L GSI Sbjct: 257 LIGA-GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFA 315 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRL---------KAYVRDPYALDLIDKLLVLDPAQR 303 + E + + ++ + L + D + +L + P +R Sbjct: 316 LSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKR 375 Query: 304 IDSDDALNHDFFWS 317 + + L H + S Sbjct: 376 ASAGECLRHPWLNS 389 >4TNB-A nrPDB Length = 590 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 121/305 (39%), Gaps = 50/305 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHEN 77 + + +G+G FGEV + R TG+ A K++ + +K AL E +IL+ + + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVL-VKFTLSEIKRVMQMLLN 135 VVNL T K ++ LV DL + N+ F +L Sbjct: 246 VVNLAYAYET--------KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILC 297 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL +H ++RD+K N+L+ G ++++D GLA RV T+ Y Sbjct: 298 GLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-----LIRGRVGTVGYM 352 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE+L +R YG D WG GC++ EM +G E+ Sbjct: 353 APEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK-------------------- 391 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDAL 310 V E+ ++ + + ++ A + LL D QR+ ++ + Sbjct: 392 VKREEVDRRVLE--------TEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVK 443 Query: 311 NHDFF 315 H FF Sbjct: 444 RHPFF 448 >3OMV-A nrPDB Length = 307 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 120/288 (41%), Gaps = 19/288 (6%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + E S+ +IG G+FG V+K + VA+K + + + E+ +L+ Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVM 130 +H N++ + K ++ +V +CE L L KF + ++ + Sbjct: 88 KTRHVNILLFMGY---------MTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIA 138 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + G+ Y+H I+HRDMK+ N+ + +K+ DFGLA S SQ Sbjct: 139 RQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT--G 196 Query: 191 TLWYRPPELL--LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 ++ + PE++ + D++ G ++ E+ T + Q+ + G Sbjct: 197 SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG-RGYA 255 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLL 296 +P++ N K LV +KVK+ + + +++L+ L Sbjct: 256 SPDLSKLYKNCPKAMK-RLVADCVKKVKEERPLFPQILSSIELLQHSL 302 >2VD5-A nrPDB Length = 412 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 112/312 (35%), Gaps = 50/312 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-ENEKEGFPITALREIKILQLL 73 + +E L IG+G F EV + ++TGQ A+K + + K G E +L Sbjct: 59 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG 118 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVMQM 132 + L + + +YLV ++ DL LLS + + + Sbjct: 119 DRRWITQLHFAFQD--------ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 170 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 ++ + +HR +HRD+K N+L+ R G ++LADFG R V T Sbjct: 171 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADG---TVRSLVAVGTP 227 Query: 193 WYRPPELLLG------ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 Y PE+L YGP D W G EM+ ++ I Sbjct: 228 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV---- 283 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-- 304 +Y+ + L LV + A D I +LL P R+ Sbjct: 284 -----------HYKEHLSLPLVDEGVPE------------EARDFIQRLLCP-PETRLGR 319 Query: 305 -DSDDALNHDFF 315 + D H FF Sbjct: 320 GGAGDFRTHPFF 331 >4E93-A nrPDB Length = 377 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 61/237 (25%), Positives = 100/237 (42%), Gaps = 14/237 (5%) Query: 21 KLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 +IG+G FGEVF R R VA+K E L+E +IL+ H N+V Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHPNIVR 176 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYY 139 LI +C K IY+V + D L + + + +++ G+ Y Sbjct: 177 LIGVCTQ--------KQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEY 228 Query: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 + +HRD+ A N L+T VLK++DFG++R + + +V W PE Sbjct: 229 LESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGL-RQVPVKWT-APEA 286 Query: 200 LLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 L R Y D+W G ++ E ++ + + Q + + PE+ P+ Sbjct: 287 LNYGR-YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPD 342 >4GS6-A nrPDB Length = 315 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 68/322 (21%), Positives = 121/322 (37%), Gaps = 65/322 (20%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + E +G+G FG V KA+ R + VA+K++ E+E++ F + E++ L Sbjct: 4 HMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAFIV----ELRQLS 57 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLVKFTLSEIKR 128 + H N+V L C + LV ++ E L +L L +T + Sbjct: 58 RVNHPNIVKLYGACL----------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 107 Query: 129 VMQMLLNGLYYIHRNK---ILHRDMKAANVLITRDGVL-KLADFGLARAFSLAKNSQPNR 184 G+ Y+H + ++HRD+K N+L+ G + K+ DFG A Sbjct: 108 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-------QTH 160 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 TN + + PE+ G +Y D++ G I+ E+ TR ++ Sbjct: 161 MTNNKGSAAWMAPEVFEGS-NYSEKCDVFSWGIILWEVITRRKPFD------------EI 207 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 G +W + L K + L+ + DP+QR Sbjct: 208 GGPAFRIMWAVHNGTRPPLIKNLPKPIES-----------------LMTRCWSKDPSQRP 250 Query: 305 DSDD---ALNH--DFFWSDPMP 321 ++ + H +F P Sbjct: 251 SMEEIVKIMTHLMRYFPGADEP 272 >2XNP-A nrPDB Length = 279 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 119/280 (42%), Gaps = 26/280 (9%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 YE L IG G++G K R + G+ + K++ + E + E+ +L+ LKH Sbjct: 5 AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-------FTLSEIKR 128 N+V + +R ++Y+V ++CE G L++V+ K + R Sbjct: 65 PNIVRYYD------RIIDRTNTTLYIVMEYCE---GGDLASVITKGTKERQYLDEEFVLR 115 Query: 129 VMQMLLNGLYYIHR-----NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 VM L L HR + +LHRD+K ANV + +KL DFGLAR N + Sbjct: 116 VMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL----NHDTS 171 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 V T +Y PE + Y D+W GC++ E+ P +++ I + Sbjct: 172 FAKTFVGTPYYMSPEQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIRE 230 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 P + + N + L L + V++ L+ + Sbjct: 231 GKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPL 270 >3FME-A nrPDB Length = 290 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 57/311 (18%), Positives = 111/311 (35%), Gaps = 53/311 (17%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI-LQLL 73 + E + ++G+G +G V K RH +GQ +A+K++ L ++ I ++ + Sbjct: 5 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRA-TVNSQEQKRLLMDLDISMRTV 63 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVM 130 V +G +++ + + L V+ K + ++ Sbjct: 64 DCPFTVTFYGAL--------FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 115 Query: 131 QMLLNGLYYIHRN-KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 ++ L ++H ++HRD+K +NVLI G +K+ DFG++ + Sbjct: 116 VSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDID-----A 170 Query: 190 VTLWYRPPELL---LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLC 245 Y PE + L ++ Y D+W G M E+ R P T QL + + Sbjct: 171 GCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-- 228 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 + +L A +D + L + +R Sbjct: 229 ----------------------------EPSPQLPADKFSAEFVDFTSQCLKKNSKERPT 260 Query: 306 SDDALNHDFFW 316 + + H FF Sbjct: 261 YPELMQHPFFT 271 >6NPU-A nrPDB Length = 298 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 62/336 (18%), Positives = 122/336 (36%), Gaps = 55/336 (16%) Query: 2 AKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 + YD E E + K+G G +GEV++ +K VA+K + + + Sbjct: 15 SPNYDKWEM----ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VE 67 Query: 62 TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVK 120 L+E +++ +KH N+V L+ +C + Y++ +F +L L + Sbjct: 68 EFLKEAAVMKEIKHPNLVQLLGVCT--------REPPFYIITEFMTYGNLLDYLRECNRQ 119 Query: 121 FTLSEIKRVMQ-MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 + + M + + + Y+ + +HRD+ A N L+ + ++K+ADFGL+R + + Sbjct: 120 EVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT--GD 177 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQL 238 + + W PE L + + D+W G ++ E+ T G Sbjct: 178 TYTAHAGAKFPIKWT-APESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVY 235 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 L+ + PE P +L+ Sbjct: 236 ELLEKDYRMERPEGCP-------------------------------EKVYELMRACWQW 264 Query: 299 DPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTS 334 +P+ R + H F + S + + L Sbjct: 265 NPSDRPSFAEI--HQAFETMFQESSISDEVEKELGK 298 >4FR4-A nrPDB Length = 384 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 105/296 (35%), Gaps = 49/296 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT-ALREIKILQLL 73 +E L IG+G+FG+V + T + A+K + + E + +E++I+Q L Sbjct: 13 NFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGL 72 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 +H +VNL + + +++V D V F +K + L Sbjct: 73 EHPFLVNLWYSFQDEED--------MFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICEL 124 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 + L Y+ +I+HRDMK N+L+ G + + DF +A + + T T Sbjct: 125 VMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLP-----RETQITTMAGTKP 179 Query: 194 YRPPELLLGER--DYGPPIDLWGAGCIMAEMWTRSPIMQ--GNTEQHQLALISQLCGSIT 249 Y PE+ + Y +D W G E+ +T ++ + Sbjct: 180 YMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTY 239 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 P W + L+ KLL +P QR Sbjct: 240 PSAW-------------------------------SQEMVSLLKKLLEPNPDQRFS 264 >4E20-A nrPDB Length = 290 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 121/295 (41%), Gaps = 35/295 (11%) Query: 18 KY-EKLAKIGQGTFGEV----FKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQL 72 +Y +K+ +G+G FG+V + + TG+ VA+K + E REI+IL+ Sbjct: 8 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKAL-KEGCGPQLRSGWQREIEILRT 66 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT--LSEIKRVM 130 L HE++V C + S+ LV ++ G L + L + L+++ Sbjct: 67 LYHEHIVKYKGCCEDQGE------KSVQLVMEYVP---LGSLRDYLPRHCVGLAQLLLFA 117 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 Q + G+ Y+H +HR + A NVL+ D ++K+ DFGLA+A R Sbjct: 118 QQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 177 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 WY PE L + Y D+W G + E+ T ++ Q ++L G Sbjct: 178 VFWY-APECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIG---- 226 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 + L E LE +G++ DR L+ + + R Sbjct: 227 HTQGQMTVLRLTELLE--RGERLPRPDRCPC-----EIYHLMKNCWETEASFRPT 274 >3KUL-B nrPDB Length = 325 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 19/283 (6%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQK---VALKKVLMENEKEGFPITALREIKILQ 71 E S+ IG G GEV R R GQ+ VA+K + E L E I+ Sbjct: 47 EASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKAL-KAGYTERQRRDFLSEASIMG 105 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVM 130 H N++ L + +V ++ E L L +FT+ ++ ++ Sbjct: 106 QFDHPNIIRLEGVVTRGRLA--------MIVTEYMENGSLDTFLRTHDGQFTIMQLVGML 157 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + G+ Y+ +HRD+ A NVL+ + V K++DFGL+R ++ ++ Sbjct: 158 RGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIP 217 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 W PE + R + D+W G +M E+ T + ++ + + Sbjct: 218 IRWT-APEAI-AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPA 275 Query: 250 PEVWPNVDNY---ELYEKLELVKGQKRKVKDRLKAYVRDPYAL 289 P P+ + + + K + + ++ L A +R P +L Sbjct: 276 PMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESL 318 >6DBN-A nrPDB Length = 316 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 124/311 (39%), Gaps = 31/311 (9%) Query: 1 MAKQYDSVECPFCDEVSKY-EKLAKIGQGTFGEVFKARHRK----TGQKVALKKVLMENE 55 ++++ + E ++ +++ +G+G FG+V R+ TG++VA+K + E+ Sbjct: 18 VSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES- 76 Query: 56 KEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL 114 +EI+IL+ L HEN+V IC I L+ +F L L Sbjct: 77 GGNHIADLKKEIEILRNLYHENIVKYKGICTEDGG------NGIKLIMEFLPSGSLKEYL 130 Query: 115 SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF 174 K L + + + G+ Y+ + +HRD+ A NVL+ + +K+ DFGL +A Sbjct: 131 PKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAI 190 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 K + WY PE L+ + Y D+W G + E+ T +++ Sbjct: 191 ETDKEYYTVKDDRDSPVFWY-APECLMQSKFY-IASDVWSFGVTLHELLT-----YCDSD 243 Query: 235 QHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDK 294 +AL ++ G P + + +K KR L+ K Sbjct: 244 SSPMALFLKMIG-------PTHGQMTVTRLVNTLKEGKRLPCPPNCP----DEVYQLMRK 292 Query: 295 LLVLDPAQRID 305 P+ R Sbjct: 293 CWEFQPSNRTS 303 >4PDO-A nrPDB Length = 299 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 110/264 (41%), Gaps = 17/264 (6%) Query: 20 EKLAKIGQGTFGEVFKARHR-KTGQK---VALKKVLMENEKEGFPITALREIKILQLLKH 75 + IG G FGEV+K + +G+K VA+K + E + L E I+ H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTL-KAGYTEKQRVDFLGEAGIMGQFSH 95 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLL 134 N++ L + + ++ ++ E+ L L +F++ ++ +++ + Sbjct: 96 HNIIRLEGVI--------SKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIA 147 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+ +HRD+ A N+L+ + V K++DFGL+R + ++ W Sbjct: 148 AGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWT 207 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVW 253 PE + R + D+W G +M E+ T + + I+ TP Sbjct: 208 -APEAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDC 265 Query: 254 PNVDNYELYEKLELVKGQKRKVKD 277 P+ + + + + ++ K D Sbjct: 266 PSAIYQLMMQCWQQERARRPKFAD 289 >3ORP-A nrPDB Length = 311 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 53/219 (24%), Positives = 96/219 (43%), Gaps = 7/219 (3%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE-GFPITALREIKILQLLKH 75 +YE +G G EV AR + + VA+K + + ++ F + RE + L H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +V + + Y+V ++ + + + T V+ Sbjct: 72 PAIVAVYD----TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L + H+N I+HRD+K AN++I+ +K+ DFG+ARA + + NS + + T Y Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNS-VTQTAAVIGTAQYL 186 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 PE G+ D++ GC++ E+ T P G++ Sbjct: 187 SPEQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSP 224 >2XYN-A nrPDB Length = 292 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 111/282 (39%), Gaps = 25/282 (8%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + E + K+G G +GEV+ +K VA+K + + + L+E +++ Sbjct: 27 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMK 83 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV-LVKFTLSEIKRV 129 +KH N+V L+ +C + Y+V ++ +L L + T + + Sbjct: 84 EIKHPNLVQLLGVCT--------LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYM 135 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + + + Y+ + +HRD+ A N L+ + V+K+ADFGL+R + ++ + Sbjct: 136 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT--GDTYTAHAGAKF 193 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSI 248 W P L + D+W G ++ E+ T G L+ + Sbjct: 194 PIKWTAPESLAYNT--FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRME 251 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 PE P + EL++ + ++ A + Sbjct: 252 QPEGCP-------PKVYELMRACWKWSPADRPSFAETHQAFE 286 >3ALO-A nrPDB Length = 327 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 111/314 (35%), Gaps = 49/314 (15%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + L +IG+G +G V K H+ +GQ +A+K++ +++ + +++ Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKF----TLSEIK 127 +V +G ++ + V + Sbjct: 77 SSDCPYIVQFYGAL--------FREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILG 128 Query: 128 RVMQMLLNGLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ + L ++ KI+HRD+K +N+L+ R G +KL DFG++ + T Sbjct: 129 KITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-----IAKT 183 Query: 187 NRVVTLWYRPPELL---LGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALIS 242 Y PE + + Y D+W G + E+ T P + N+ QL + Sbjct: 184 RDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVV 243 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + P + N E E P ++ ++ L D ++ Sbjct: 244 KG-------DPPQLSNSEERE--------------------FSPSFINFVNLCLTKDESK 276 Query: 303 RIDSDDALNHDFFW 316 R + L H F Sbjct: 277 RPKYKELLKHPFIL 290 >3C51-A nrPDB Length = 543 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 111/311 (35%), Gaps = 51/311 (16%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF-PITALREIKILQLLKH 75 + +G+G FGEVF + + TG+ A KK+ + K+ A+ E KIL + Sbjct: 185 DWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHS 244 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGL----LSNVLVKFTLSEIKRVMQ 131 +V+L TK + LV + F Sbjct: 245 RFIVSLAYAFETKTD--------LCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTA 296 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 +++GL ++H+ I++RD+K NVL+ DG ++++D GLA + T Sbjct: 297 QIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAG----QTKTKGYAGT 352 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + PELLLGE Y +D + G + EM + E Sbjct: 353 PGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARGE----------------- 394 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DS 306 E E + V Q D+ P + D + LL DP +R+ Sbjct: 395 ------KVENKELKQRVLEQAVTYPDKF-----SPASKDFCEALLQKDPEKRLGFRDGSC 443 Query: 307 DDALNHDFFWS 317 D H F Sbjct: 444 DGLRTHPLFRD 454 >5H2U-A nrPDB Length = 267 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 109/280 (38%), Gaps = 20/280 (7%) Query: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73 ++ K+G G FGEVF+ + +VA+K + +N EI+ ++ L Sbjct: 3 RPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNL--LHQQMLQSEIQAMKKL 59 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVK-FTLSEIKRVMQ 131 +H++++ L + +Y++ + + L LL + K +SE+ + Sbjct: 60 RHKHILALYAVV--------SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAW 111 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + G+ Y+ +HRD+ A N+L+ + + K+ DFGLAR + + Sbjct: 112 QVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHN----IP 167 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSP-IMQGNTEQHQLALISQLCGSITP 250 + PE L Y D+W G ++ EM++R G + + P Sbjct: 168 YKWTAPEAL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCP 226 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 P ++L ++R L+ + + Sbjct: 227 LECP-PSVHKLMLTCWCRDPEQRPTFKALRERLSSFTSHH 265 >4PWN-A nrPDB Length = 274 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 120/307 (39%), Gaps = 51/307 (16%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 K++ +IG+G+F V+K +T +VA ++ + E ++L+ L+H N Sbjct: 13 KFDI--EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPN 70 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEI---KRVMQMLL 134 +V + + + K I LV + +G L L +F + +I + + +L Sbjct: 71 IVRFYDSWESTV----KGKKCIVLVTELMT---SGTLKTYLKRFKVMKIKVLRSWCRQIL 123 Query: 135 NGLYYIHRNK--ILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 GL ++H I+HRD+K N+ IT G +K+ D GLA + + + + T Sbjct: 124 KGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-----EKRASFAKSVIGT 178 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 + PE+ E Y +D++ G M EM T Sbjct: 179 PEFMAPEMY--EEKYDESVDVYAFGMCMLEMATSEYPY---------------------- 214 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 E ++ + VK V P ++I+ + + +R D LN Sbjct: 215 -------SECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLN 267 Query: 312 HDFFWSD 318 H FF + Sbjct: 268 HAFFQEE 274 >4AT3-A nrPDB Length = 299 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 119/283 (42%), Gaps = 36/283 (12%) Query: 21 KLAKIGQGTFGEVFKARH-----RKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++G+G FG+VF A + VA+K + ++ + RE ++L L+H Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTL--KDASDNARKDFHREAELLTNLQH 74 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS------------NVLVKFT 122 E++V +C + +VF++ +H DL L N + T Sbjct: 75 EHIVKFYGVCVEG--------DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 126 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 S++ + Q + G+ Y+ +HRD+ N L+ + ++K+ DFG++R + Sbjct: 127 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRV 186 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI 241 +T ++ + + PPE ++ R + D+W G ++ E++T + + I Sbjct: 187 GGHT--MLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECI 243 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR 284 +Q P P E+YE + ++ ++ +K Sbjct: 244 TQGRVLQRPRTCP----QEVYELMLGCWQREPHMRKNIKGIHT 282 >4EQM-A nrPDB Length = 294 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 120/292 (41%), Gaps = 26/292 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV-LMENEKEGFPITALREIKILQLLKH 75 +Y+ + K+G G V+ A KVA+K + + EKE RE+ L H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 +N+V++I++ YLV ++ E ++ +L+ Sbjct: 71 QNIVSMIDVDEEDDCY--------YLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILD 122 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 G+ + H +I+HRD+K N+LI + LK+ DFG+A+A S +Q N + T+ Y Sbjct: 123 GIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHV---LGTVQYF 179 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE-----QHQLALISQLCGSITP 250 PE GE D++ G ++ EM P G T +H + + + Sbjct: 180 SPEQAKGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRK 238 Query: 251 EVWPNVDNYELY-------EKLELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 ++ ++ N L + + ++ K + L + +L DK+ Sbjct: 239 DIPQSLSNVILRATEKDKANRYKTIQEMKDDLSSVLHENRANEDVYEL-DKM 289 >4M7I-A nrPDB Length = 299 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 118/294 (40%), Gaps = 32/294 (10%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++ +E + +G+G FG VF+A+++ A+K++ + N +E +RE+K L L+H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEH 62 Query: 76 ENVVNLIEIC----RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK---R 128 +V T+ + K +Y+ C + N E Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP------ 182 + + + ++H ++HRD+K +N+ T D V+K+ DFGL A + Q Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 183 --NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 R+T +V T Y PE + G Y +D++ G I+ E+ P Q+ Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL--YPF------STQMER 233 Query: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDK 294 + L + P E + + +R P A+++I+ Sbjct: 234 VRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMER-------PEAINIIEN 280 >4WUA-A nrPDB Length = 401 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 77/376 (20%), Positives = 144/376 (38%), Gaps = 90/376 (23%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH- 75 +Y + K+G G F V+ + + + VA+K V E + TAL EI++L+ +++ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVV---KSAEHYTETALDEIRLLKSVRNS 97 Query: 76 -EN------VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAG-LLSNVLVKFTLSEIK 127 N VV L++ + I +VF+ H L ++ + L +K Sbjct: 98 DPNDPNREMVVQLLDDFKISG----VNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVK 153 Query: 128 RVMQMLLNGLYYIHRN-KILHRDMKAANVLIT---------------------------- 158 +++Q +L GL Y+H +I+H D+K N+L++ Sbjct: 154 KIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSA 213 Query: 159 ---------------------RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 +K+AD G A +T + T YR Sbjct: 214 VSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH-------KHFTEDIQTRQYRSL 266 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNT------EQHQLALISQLCGSITPE 251 E+L+G Y P D+W C+ E+ T + + ++ ++ +ALI +L G + + Sbjct: 267 EVLIGS-GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRK 325 Query: 252 VW-PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY---------ALDLIDKLLVLDPA 301 + + E + K +K + L + + Y D + +L L P Sbjct: 326 LIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPE 385 Query: 302 QRIDSDDALNHDFFWS 317 +R + + L H + S Sbjct: 386 KRATAAECLRHPWLNS 401 >4XUF-A nrPDB Length = 297 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 122/305 (40%), Gaps = 42/305 (13%) Query: 9 ECPFCDEVSKYEKLAKIGQGTFGEVFKARH---RKTGQ--KVALKKVLMENEKEGFPITA 63 + + E +G G FG+V A KTG +VA+K +L E Sbjct: 1 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVK-MLKEKADSSEREAL 59 Query: 64 LREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKF 121 + E+K++ L HEN+VNL+ C G IYL+F++C DL L + KF Sbjct: 60 MSELKMMTQLGSHENIVNLLGACT--------LSGPIYLIFEYCCYGDLLNYLRSKREKF 111 Query: 122 TLSEIKR----------------------VMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 + EI+ + G+ ++ +HRD+ A NVL+T Sbjct: 112 SEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 171 Query: 160 DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 V+K+ DFGLAR ++ ++ R R+ W PE L E Y D+W G ++ Sbjct: 172 GKVVKICDFGLARDI-MSDSNYVVRGNARLPVKW-MAPESLF-EGIYTIKSDVWSYGILL 228 Query: 220 AEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 E+++ G + Q + + + Y + + +KR Sbjct: 229 WEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPN 288 Query: 279 LKAYV 283 L +++ Sbjct: 289 LTSFL 293 >4EBW-A nrPDB Length = 304 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 105/303 (34%), Gaps = 50/303 (16%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMENEKEGFPITA 63 S + + + E IG+G FG+V + + VA+K + Sbjct: 28 SSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTC-KNCTSDSVREKF 86 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFT 122 L+E ++ H ++V LI + + ++++ + C +L L Sbjct: 87 LQEALTMRQFDHPHIVKLIGVI---------TENPVWIIMELCTLGELRSFLQVRKYSLD 137 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 L+ + L L Y+ + +HRD+ A NVL++ + +KL DFGL+R + + Sbjct: 138 LASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKA 197 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI 241 ++ ++ W PE + R + D+W G M E+ QG + I Sbjct: 198 SK--GKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P P P L+ K DP+ Sbjct: 254 ENGERLPMPPNCP-------------------------------PTLYSLMTKCWAYDPS 282 Query: 302 QRI 304 +R Sbjct: 283 RRP 285 >3V5Q-A nrPDB Length = 297 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 117/311 (37%), Gaps = 66/311 (21%) Query: 21 KLAKIGQGTFGEVFKARH-----RKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++G+G FG+VF A K VA+K +++ RE ++L L+H Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK--ALKDPTLAARKDFQREAELLTNLQH 76 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS---------------NVLV 119 E++V +C + +VF++ +H DL L Sbjct: 77 EHIVKFYGVCGDG--------DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 128 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 + LS++ + + +G+ Y+ +HRD+ N L+ + ++K+ DFG++R Sbjct: 129 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDY 188 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQL 238 + +T ++ + + PPE ++ R + D+W G I+ E++T + + Sbjct: 189 YRVGGHT--MLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 I+Q P V P D++ Sbjct: 246 ECITQGRVLERPRVCPK-------------------------------EVYDVMLGCWQR 274 Query: 299 DPAQRIDSDDA 309 +P QR++ + Sbjct: 275 EPQQRLNIKEI 285 >2JD5-A nrPDB Length = 373 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 141/342 (41%), Gaps = 52/342 (15%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P+ D ++Y + K+G G F V+ A+ VA+K V + + A EIK+L Sbjct: 15 PYKD--ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKV---YTEAAEDEIKLL 69 Query: 71 QLLKHE-----------NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 Q + +++ L++ K + +VF+ +L L+ Sbjct: 70 QRVNDADNTKEDSMGANHILKLLDHFNHKGP----NGVHVVMVFEVLGENLLALIKKYEH 125 Query: 120 K-FTLSEIKRVMQMLLNGLYYIHRN-KILHRDMKAANVLITRDG------VLKLADFGLA 171 + L +K++ + LL GL Y+HR I+H D+K NVL+ +K+AD G A Sbjct: 126 RGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA 185 Query: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 + YTN + T YR PE+LLG +G D+W C++ E+ T + + Sbjct: 186 CWYD-------EHYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEP 237 Query: 232 NT------EQHQLALISQLCGSITPEVWPN-------VDNYELYEKLELVKGQKRKVKDR 278 + + +A I +L G + + N ++ L + +K + Sbjct: 238 DEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLT 297 Query: 279 LKAYVRDPYAL---DLIDKLLVLDPAQRIDSDDALNHDFFWS 317 K A D + +L LDP +R D+ +NH + Sbjct: 298 EKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >5X02-A nrPDB Length = 347 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 74/311 (23%), Positives = 126/311 (40%), Gaps = 43/311 (13%) Query: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARH---RKTGQ--KVALKKVLMENEKE 57 ++Y+ + + E +G G FG+V A KTG +VA+K +L E Sbjct: 35 REYEY-DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVK-MLKEKADS 92 Query: 58 GFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLS 115 + E+K++ L HEN+VNL+ C G IYL+F++C DL L Sbjct: 93 SEREALMSELKMMTQLGSHENIVNLLGACT--------LSGPIYLIFEYCCYGDLLNYLR 144 Query: 116 NVLVKFTLSEIKR----------------------VMQMLLNGLYYIHRNKILHRDMKAA 153 + KF+ EI+ + G+ ++ +HRD+ A Sbjct: 145 SKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAAR 204 Query: 154 NVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLW 213 NVL+T V+K+ DFGLAR ++ ++ R R+ W PE L E Y D+W Sbjct: 205 NVLVTHGKVVKICDFGLARDI-MSDSNYVVRGNARLPVKW-MAPESLF-EGIYTIKSDVW 261 Query: 214 GAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK 272 G ++ E+++ G + Q + + + Y + + +K Sbjct: 262 SYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRK 321 Query: 273 RKVKDRLKAYV 283 R L +++ Sbjct: 322 RPSFPNLTSFL 332 >3A4O-X nrPDB Length = 286 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 122/283 (43%), Gaps = 24/283 (8%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D+ E P + + ++G G FGEV+ + + KVA+K + L Sbjct: 6 DAWEIPRESI----KLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMS---VQAFLE 57 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLL-SNVLVKFTL 123 E +++ L+H+ +V L + + IY++ ++ + L L S+ K L Sbjct: 58 EANLMKTLQHDKLVRLYAVVTREE--------PIYIITEYMAKGSLLDFLKSDEGGKVLL 109 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + G+ YI R +HRD++AANVL++ + K+ADFGLAR N Sbjct: 110 PKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE--DNEYTA 167 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W P + G + D+W G ++ E+ T G T + +S Sbjct: 168 REGAKFPIKWTAPEAINFGC--FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALS 225 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 Q E P+ + Y++ + K ++R D L++ + D Sbjct: 226 QGYRMPRVENCPD-ELYDIMKMCWKEKAEERPTFDYLQSVLDD 267 >5A46-A nrPDB Length = 386 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 79/355 (22%), Positives = 145/355 (40%), Gaps = 47/355 (13%) Query: 4 QYDSVECPFCD-EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-------KVALKKVLMENE 55 +Y+ E P + + +G+G FG+V A + KVA+K +L + Sbjct: 26 EYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVK-MLKSDA 84 Query: 56 KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGL 113 E + E+++++++ KH+N++NL+ C G +Y++ ++ +L Sbjct: 85 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQD--------GPLYVIVEYASKGNLREY 136 Query: 114 L---------------SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT 158 L N + + ++ + G+ Y+ K +HRD+ A NVL+T Sbjct: 137 LQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT 196 Query: 159 RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI 218 D V+K+ADFGLAR + + TN + + + PE L +R Y D+W G + Sbjct: 197 EDNVMKIADFGLARDIHHIDYYK--KTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVL 253 Query: 219 MAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK- 276 + E++T G + L+ + P N + + V Q+ K Sbjct: 254 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 313 Query: 277 -----DRLKAYVRDPYALDLIDKLLVLDPA---QRIDSDDALNHDFFWSDPMPSD 323 DR+ A + LDL L P+ R + + F +P+P + Sbjct: 314 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEE 368 >3TT0-A nrPDB Length = 382 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 127/308 (41%), Gaps = 42/308 (13%) Query: 4 QYDSVECPFCD-EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-------KVALKKVLMENE 55 +Y+ E P + + +G+G FG+V A + KVA+K +L + Sbjct: 55 EYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVK-MLKSDA 113 Query: 56 KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGL 113 E + E+++++++ KH+N++NL+ C G +Y++ ++ +L Sbjct: 114 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQD--------GPLYVIVEYASKGNLREY 165 Query: 114 L---------------SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT 158 L N + + ++ + G+ Y+ K +HRD+ A NVL+T Sbjct: 166 LQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT 225 Query: 159 RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI 218 D V+K+ADFGLAR + + TN + + + PE L +R Y D+W G + Sbjct: 226 EDNVMKIADFGLARDIHHIDYYK--KTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVL 282 Query: 219 MAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKD 277 + E++T G + L+ + P N ELY + + Sbjct: 283 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTN----ELYMMMRDCWHAVPSQRP 338 Query: 278 RLKAYVRD 285 K V D Sbjct: 339 TFKQLVED 346 >1LUF-A nrPDB Length = 343 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 118/314 (37%), Gaps = 56/314 (17%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLMENEKEGFPITALREIKI 69 + E + IG+G FG VF+AR + VA+K +L E RE + Sbjct: 45 PRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVK-MLKEEASADMQADFQREAAL 103 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV----------- 117 + + N+V L+ +C + L+F++ DL L ++ Sbjct: 104 MAEFDNPNIVKLLGVC--------AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHS 155 Query: 118 ------------LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKL 165 + +E + + + G+ Y+ K +HRD+ N L+ + V+K+ Sbjct: 156 DLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKI 215 Query: 166 ADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT- 224 ADFGL+R A + + N + + + PPE + R Y D+W G ++ E+++ Sbjct: 216 ADFGLSRNIYSADYYKAD--GNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIFSY 272 Query: 225 RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR 284 G + + + PE P E L++ K+ ++ Sbjct: 273 GLQPYYGMAHEEVIYYVRDGNILACPENCP-------LELYNLMRLCWSKLPADRPSFCS 325 Query: 285 DPYALDLIDKLLVL 298 I ++L Sbjct: 326 -------IHRILQR 332 >3QGY-A nrPDB Length = 286 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 99/240 (41%), Gaps = 18/240 (7%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 + S+ + +IG G FG V KVA+K + + E + E +++ L Sbjct: 25 DPSELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDD---FIEEAEVMMKLS 80 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQML 133 H +V L +C +A I LVF+F EH L+ L F + + + Sbjct: 81 HPKLVQLYGVCLEQA--------PICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDV 132 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ ++HRD+ A N L+ + V+K++DFG+ R + Q T + Sbjct: 133 CEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV---LDDQYTSSTGTKFPVK 189 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEV 252 + PE+ Y D+W G +M E+++ + + + IS P + Sbjct: 190 WASPEVF-SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRL 248 >6CCF-A nrPDB Length = 290 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 72/326 (22%), Positives = 127/326 (38%), Gaps = 67/326 (20%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--------------- 59 ++++Y+ ++IG+G +G V A + + A+K + + + + Sbjct: 3 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQ 62 Query: 60 ---------PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL 110 +EI IL+ L H NVV LIE+ A ++YLVFD Sbjct: 63 GGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAE------DNLYLVFDLLRKGP 116 Query: 111 AGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGL 170 + F+ + + ++ ++ GL Y+H KI+HRD+K +N+L+ DG +K+ADFG+ Sbjct: 117 VMEVP-CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGV 175 Query: 171 ARAFSLAKNSQPNRYTNRVVTLWYRPPELL--LGERDYGPPIDLWGAGCIMAEMWTRSPI 228 + F + ++ T + PE + G+ G +D+W G + Sbjct: 176 SNQFE----GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP 231 Query: 229 MQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYA 288 + LAL ++ P V+P Sbjct: 232 F---IDDFILALHRKIKNE--PVVFPEEPEI-------------------------SEEL 261 Query: 289 LDLIDKLLVLDPAQRIDSDDALNHDF 314 DLI K+L +P RI D H + Sbjct: 262 KDLILKMLDKNPETRIGVPDIKLHPW 287 >3IO7-A nrPDB Length = 313 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 122/298 (40%), Gaps = 37/298 (12%) Query: 14 DEVSKYE-----KLAKIGQGTFGEVFKARHRK----TGQKVALKKVLMENEKEGFPITAL 64 ++++E L ++G+G FG V R+ TG+ VA+KK+ E Sbjct: 20 HNMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--EEHLRDFE 77 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTL 123 REI+IL+ L+H+N+V +C Y+ + ++ L+ ++ L L + Sbjct: 78 REIEILKSLQHDNIVKYKGVC------YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH 131 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + + G+ Y+ + +HRD+ N+L+ + +K+ DFGL + K Sbjct: 132 IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV 191 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-----RSPI-----MQGNT 233 + WY PE L E + D+W G ++ E++T +SP M GN Sbjct: 192 KEPGESPIFWY-APESL-TESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND 249 Query: 234 EQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 +Q Q+ + + P D + + + V R P DL Sbjct: 250 KQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR-------PSFRDL 300 >4HVI-A nrPDB Length = 314 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 110/291 (37%), Gaps = 31/291 (10%) Query: 20 EKLAKIGQGTFGEVFKARHRK----TGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + ++++G+G FG V R+ TG VA+K++ + REI+IL+ L Sbjct: 13 KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ--RDFQREIQILKALHS 70 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLL 134 + +V + Y + S+ LV ++ L L + S + + Sbjct: 71 DFIVKYRGV------SYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQIC 124 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+ + +HRD+ A N+L+ + +K+ADFGLA+ L K+ R + WY Sbjct: 125 KGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY 184 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE L + + D+W G ++ E++T S + E Sbjct: 185 -APESL-SDNIFSRQSDVWSFGVVLYELFT----------------YCDKSCSPSAEFLR 226 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 + + L + + + +L+ P R Sbjct: 227 MMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >3GQL-A nrPDB Length = 326 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 133/320 (41%), Gaps = 44/320 (13%) Query: 4 QYDSVECPFCD-EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-------KVALKKVLMENE 55 +Y+ E P + + +G+G FG+V A + KVA+K +L + Sbjct: 14 EYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVK-MLKSDA 72 Query: 56 KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGL 113 E + E+++++++ KH+N++NL+ C G +Y++ ++ +L Sbjct: 73 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQD--------GPLYVIVEYASKGNLREY 124 Query: 114 L---------------SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT 158 L N + + ++ + G+ Y+ K +HRD+ A NVL+T Sbjct: 125 LQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT 184 Query: 159 RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI 218 D V+K+ADFGLAR + + TN + + + PE L +R Y D+W G + Sbjct: 185 EDNVMKIADFGLARDIHHIDYYK--KTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVL 241 Query: 219 MAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK- 276 + E++T G + L+ + P N + + V Q+ K Sbjct: 242 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 301 Query: 277 -----DRLKAYVRDPYALDL 291 DR+ A + LDL Sbjct: 302 LVEDLDRIVALTSNQEYLDL 321 >1TKI-A nrPDB Length = 321 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 110/304 (36%), Gaps = 48/304 (15%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 KY +G+G FG V + + + K V ++ + + +EI IL + +H Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQ---VLVKKEISILNIARHR 61 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLN 135 N+++L E + + ++F+F D+ ++ + EI + + Sbjct: 62 NILHLHESFESMEE--------LVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 113 Query: 136 GLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 L ++H + I H D++ N++ R +K+ +FG AR N + Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA-----PE 168 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Y PE+ D+W G ++ + + T Q + I + E + Sbjct: 169 YYAPEV-HQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAF 227 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 + A+D +D+LLV + R+ + +AL H Sbjct: 228 KEI----------------------------SIEAMDFVDRLLVKERKSRMTASEALQHP 259 Query: 314 FFWS 317 + Sbjct: 260 WLKQ 263 >5UUU-A nrPDB Length = 547 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 123/323 (38%), Gaps = 52/323 (16%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEK-EGFPIT 62 Q+ +VE ++ + IG+G FGEV+ R TG+ A+K + + K + Sbjct: 185 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 244 Query: 63 ALREIKILQLL---KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 AL E +L L+ +V + T + + D + Sbjct: 245 ALNERIMLSLVSTGDCPFIVCMSYAFHTP--------DKLSFILDLMNGGDLHYHLSQHG 296 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 F+ ++++ ++ GL ++H +++RD+K AN+L+ G ++++D GLA FS K Sbjct: 297 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 356 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 V T Y PE+L Y D + GC++ ++ + + + + Sbjct: 357 H------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-H 409 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 I ++ ++ E+ + P L++ LL D Sbjct: 410 EIDRMTLTMAVELPDSF----------------------------SPELRSLLEGLLQRD 441 Query: 300 PAQRI-----DSDDALNHDFFWS 317 +R+ + + FF S Sbjct: 442 VNRRLGCLGRGAQEVKESPFFRS 464 >5HIE-A nrPDB Length = 302 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 121/294 (41%), Gaps = 28/294 (9%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D E P + +IG G+FG V+K + VA+K +L + + F Sbjct: 29 DDWEIPD----GQITVGQRIGSGSFGTVYKGKWHGD---VAVK-MLTPQQLQAFK----N 76 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLS 124 E+ +L+ +H N++ + K + +V +CE L L + KF + Sbjct: 77 EVGVLRKTRHVNILLFMGY---------STKPQLAIVTQWCEGSSLYHHLHIIETKFEMI 127 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 ++ + + G+ Y+H I+HRD+K+ N+ + D +K+ DFGLA S S + Sbjct: 128 KLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSH--Q 185 Query: 185 YTNRVVTLWYRPPELL--LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + ++ + PE++ + Y D++ G ++ E+ T + Q+ I Sbjct: 186 FEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI--IF 243 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLL 296 + V + L+ +K +D + + +++L+ + L Sbjct: 244 MVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 297 >2J0K-A nrPDB Length = 656 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 103/303 (33%), Gaps = 50/303 (16%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHR---KTGQKVALKKVLMENEKEGFPITA 63 + + + E IG+G FG+V + + VA+K + Sbjct: 380 PSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTC-KNCTSDSVREKF 438 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFT 122 L+E ++ H ++V LI + + ++++ + C +L L Sbjct: 439 LQEALTMRQFDHPHIVKLIGVI---------TENPVWIIMELCTLGELRSFLQVRKFSLD 489 Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 L+ + L L Y+ + +HRD+ A NVL++ +KL DFGL+R + + Sbjct: 490 LASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKA 549 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI 241 ++ ++ W PE + R + D+W G M E+ QG + I Sbjct: 550 SK--GKLPIKW-MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 P P P L+ K DP+ Sbjct: 606 ENGERLPMPPNCP-------------------------------PTLYSLMTKCWAYDPS 634 Query: 302 QRI 304 +R Sbjct: 635 RRP 637 >5VO2-A nrPDB Length = 300 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 71/339 (20%), Positives = 119/339 (35%), Gaps = 63/339 (18%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D E PF + + L +G G G VF R G++VA+KKV E + Sbjct: 5 DLWEVPFEEILD----LQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD-------- 50 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE 125 IK L+ LKH N++ +C ++ +FC + T S Sbjct: 51 -IKHLRKLKHPNIITFKGVCTQAPCY--------CILMEFCAQGQLYEVLRAGRPVTPSL 101 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 + + G+ Y+H +KI+HRD+K+ N+LIT D V+K++DFG ++ S Sbjct: 102 LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM---- 157 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 + T+ + PE++ E +D+W G ++ E+ T + + I Sbjct: 158 -SFAGTVAWMAPEVIRNE-PVSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGV 211 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 GS + + D K L+ + P R Sbjct: 212 GSNSLHL-----------------PVPSSCPDGFKI---------LLRQCWNSKPRNRPS 245 Query: 306 SDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRR 344 L H D +D+ + Sbjct: 246 FRQILLH----LDIASADVLSTPQETYFKSQAEWREEVK 280 >2W1I-A nrPDB Length = 326 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 118/287 (41%), Gaps = 32/287 (11%) Query: 20 EKLAKIGQGTFGEVFKARHRK----TGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 + L ++G+G FG V R+ TG+ VA+KK+ E REI+IL+ L+H Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST--EEHLRDFEREIEILKSLQH 101 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLL 134 +N+V +C Y+ + ++ L+ ++ L L + ++ + + Sbjct: 102 DNIVKYKGVC------YSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQIC 155 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 G+ Y+ + +HRD+ N+L+ + +K+ DFGL + K + WY Sbjct: 156 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY 215 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWT-----RSPI-----MQGNTEQHQLALISQL 244 PE L E + D+W G ++ E++T +SP M GN +Q Q+ + + Sbjct: 216 -APESL-TESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLI 273 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 P D + + + V R P DL Sbjct: 274 ELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR-------PSFRDL 313 >3PVW-A nrPDB Length = 695 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 63/323 (19%), Positives = 123/323 (38%), Gaps = 52/323 (16%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEK-EGFPIT 62 Q+ +VE ++ + IG+G FGEV+ R TG+ A+K + + K + Sbjct: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 Query: 63 ALREIKILQLL---KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 AL E +L L+ +V + T + + D + Sbjct: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTP--------DKLSFILDLMNGGDLHYHLSQHG 287 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 F+ ++++ ++ GL ++H +++RD+K AN+L+ G ++++D GLA FS K Sbjct: 288 VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 V T Y PE+L Y D + GC++ ++ + + + + Sbjct: 348 H------ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-H 400 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 I ++ ++ E+ + P L++ LL D Sbjct: 401 EIDRMTLTMAVELPDSF----------------------------SPELRSLLEGLLQRD 432 Query: 300 PAQRI-----DSDDALNHDFFWS 317 +R+ + + FF S Sbjct: 433 VNRRLGCLGRGAQEVKESPFFRS 455 >5KMM-A nrPDB Length = 329 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 63/322 (19%), Positives = 115/322 (35%), Gaps = 69/322 (21%) Query: 9 ECPFCDEVSKYEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLMENEKEGFPITA 63 D V K+E +G+G FG+VF A + VA+K ++ E Sbjct: 31 HIKRRDIVLKWE----LGEGAFGKVFLAECHNLLPEQDKMLVAVK--ALKEASESARQDF 84 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNV----- 117 RE ++L +L+H+++V +C + +VF++ H DL L + Sbjct: 85 QREAELLTMLQHQHIVRFFGVCTEGR--------PLLMVFEYMRHGDLNRFLRSHGPDAK 136 Query: 118 ---------LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 168 L ++ V + G+ Y+ +HRD+ N L+ + V+K+ DF Sbjct: 137 LLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDF 196 Query: 169 GLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSP 227 G++R + T ++ + + PPE +L R + D+W G ++ E++T Sbjct: 197 GMSRDIYSTDYYRVGGRT--MLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQ 253 Query: 228 IMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY 287 + + I+Q P P P Sbjct: 254 PWYQLSNTEAIDCITQGRELERPRACP-------------------------------PE 282 Query: 288 ALDLIDKLLVLDPAQRIDSDDA 309 ++ +P QR D Sbjct: 283 VYAIMRGCWQREPQQRHSIKDV 304 >4XCU-A nrPDB Length = 300 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 126/295 (42%), Gaps = 35/295 (11%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARH------RKTGQ-KVALKKVLMENEKEGFPITAL 64 + + +G+G FG+V +A R VA+K +L +N + + Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVK-MLKDNASDKDLADLV 70 Query: 65 REIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLS------N 116 E+++++L+ +H+N++NL+ +C +G +Y++ + + +L L + Sbjct: 71 SEMEVMKLIGRHKNIINLLGVCTQ--------EGPLYVIVECAAKGNLREFLRARRPPGS 122 Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 + + + G+ Y+ K +HRD+ A NVL+T D V+K+ADFGLAR Sbjct: 123 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 182 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQ 235 + + +N + + + PE L +R Y D+W G ++ E++T G + Sbjct: 183 IDYYK--KTSNGRLPVKWMAPEALF-DRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVE 239 Query: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 +L+ + P P E L++ + + + ALD Sbjct: 240 ELFSLLREGHRMDRPPHCP-------PELYGLMRECWHAAPSQRPTFKQLVEALD 287 >5HI2-A nrPDB Length = 283 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 117/276 (42%), Gaps = 27/276 (9%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D E P + +IG G+FG V+K + VA+K +L + + F Sbjct: 13 DDWEIPD----GQITVGQRIGSGSFGTVYKGKWHGD---VAVK-MLTPQQLQAFK----N 60 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLS 124 E+ +L+ +H N++ + K + +V +CE L L KF + Sbjct: 61 EVGVLRKTRHVNILLFMGY---------STKPQLAIVTQWCEGSSLYHHLHASETKFEMK 111 Query: 125 EIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 ++ + + G+ Y+H I+HRD+K+ N+ + D +K+ DFGLA S S + Sbjct: 112 KLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSH--Q 169 Query: 185 YTNRVVTLWYRPPELL--LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + ++ + PE++ Y D++ G ++ E+ T + Q+ + Sbjct: 170 FEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMV 229 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 GS++P++ N K + + K+K +R Sbjct: 230 G-RGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDER 264 >3QA8-A nrPDB Length = 676 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 63/220 (28%), Positives = 101/220 (45%), Gaps = 15/220 (6%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E ++G G FG V + H+ TG++VA+K+ E + L EI+I++ L H NV Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNV 74 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSE--IKRVMQMLLN 135 V+ E+ L ++CE DL L+ L E I+ ++ + + Sbjct: 75 VSAREV--PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISS 132 Query: 136 GLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L Y+H N+I+HRD+K N+++ + + K+ D G A+ Q T V TL Sbjct: 133 ALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELD-----QGELCTEFVGTL 187 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 Y PE LL ++ Y +D W G + E T N Sbjct: 188 QYLAPE-LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPN 226 >2PSQ-A nrPDB Length = 370 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 74/321 (23%), Positives = 135/321 (42%), Gaps = 48/321 (14%) Query: 4 QYDSVECPFCD-EVSKYEKLAKIGQGTFGEVFKA----RHRKTGQK---VALKKVLMENE 55 +Y+ E P + K +G+G FG+V A + ++ VA+K +L ++ Sbjct: 67 EYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVK-MLKDDA 125 Query: 56 KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGL 113 E + E+++++++ KH+N++NL+ C G +Y++ ++ +L Sbjct: 126 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQD--------GPLYVIVEYASKGNLREY 177 Query: 114 LSNVL---------------VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT 158 L + T ++ L G+ Y+ K +HRD+ A NVL+T Sbjct: 178 LRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT 237 Query: 159 RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI 218 + V+K+ADFGLAR + + + TN + + + PE L +R Y D+W G + Sbjct: 238 ENNVMKIADFGLARDINNIDYYK--KTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVL 294 Query: 219 MAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKD 277 M E++T G + L+ + P N ELY + + Sbjct: 295 MWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN----ELYMMMRDCWHAVPSQRP 350 Query: 278 RLKAYVRDPYALDLIDKLLVL 298 K V D +D++L L Sbjct: 351 TFKQLVED------LDRILTL 365 >2PL0-A nrPDB Length = 289 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 119/281 (42%), Gaps = 21/281 (7%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 E + + + ++G G FGEV+ + KVA+K + + P L E Sbjct: 14 WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMS---PDAFLAEA 69 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV-LVKFTLSE 125 +++ L+H+ +V L + + IY++ ++ E L L +K T+++ Sbjct: 70 NLMKQLQHQRLVRLYAVVTQE---------PIYIITEYMENGSLVDFLKTPSGIKLTINK 120 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 + + + G+ +I +HRD++AAN+L++ K+ADFGLAR N R Sbjct: 121 LLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTARE 178 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQL 244 + W P + G + D+W G ++ E+ T G T + + + Sbjct: 179 GAKFPIKWTAPEAINYGT--FTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERG 236 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 + P+ P + Y+L + + R D L++ + D Sbjct: 237 YRMVRPDNCPE-ELYQLMRLCWKERPEDRPTFDYLRSVLED 276 >4KIK-B nrPDB Length = 677 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 123/294 (41%), Gaps = 25/294 (8%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +E ++G G FG V + +++TG+++A+K+ E L EI+I++ L H NV Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNV 79 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSE--IKRVMQMLLN 135 V ++ + L ++C DL L+ L E I ++ + + Sbjct: 80 VAARDV--PEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIAS 137 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGV---LKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 L Y+H N+I+HRD+K N+++ + K+ D G A+ Q + T+ V TL Sbjct: 138 ALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELD-----QGSLCTSFVGTL 192 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEV 252 Y PELL ++ Y +D W G + E T N + Q + + V Sbjct: 193 QYLAPELLEQQK-YTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVV 251 Query: 253 WPNVD-NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 +++ + L + +RL+ + + +L+ P QR Sbjct: 252 SEDLNGTVKFSSSLPYPNNLNSVLAERLEKW---------LQLMLMWHPRQRGT 296 >4XI2-A nrPDB Length = 446 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 55/246 (22%), Positives = 106/246 (43%), Gaps = 24/246 (9%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + L ++G G FG V + R VA+K + + E + E K++ Sbjct: 182 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMSED---EFIEEAKVMM 237 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVM 130 L HE +V L +C + I+++ ++ L L + +F ++ + Sbjct: 238 NLSHEKLVQLYGVCTKQR--------PIFIITEYMANGCLLNYLREMRHRFQTQQLLEMC 289 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + + Y+ + LHRD+ A N L+ GV+K++DFGL+R + YT+ V Sbjct: 290 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV------LDDEYTSSVG 343 Query: 191 TL---WYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCG 246 + + PPE+L+ + + D+W G +M E+++ + T I+Q Sbjct: 344 SKFPVRWSPPEVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR 402 Query: 247 SITPEV 252 P + Sbjct: 403 LYRPHL 408 >5HLW-A nrPDB Length = 299 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 113/272 (41%), Gaps = 18/272 (6%) Query: 23 AKIGQGTFGEVFKARHRK-TGQKV--ALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 IG+G FG V+ G+K+ A+K + G L E I++ H NV+ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 +L+ IC R +GS +V + +H DL + N T+ ++ + G+ Sbjct: 85 SLLGICL-------RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK 137 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y+ K +HRD+ A N ++ +K+ADFGLAR + + T + + + E Sbjct: 138 YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALE 197 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 L ++ + D+W G ++ E+ TR P + Q + PE P+ Sbjct: 198 SLQTQK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD-- 254 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYAL 289 LYE + K +++ V A+ Sbjct: 255 --PLYEVMLKCWHPKAEMRPSFSELVSRISAI 284 >6GQK-A nrPDB Length = 328 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 65/334 (19%), Positives = 114/334 (34%), Gaps = 71/334 (21%) Query: 6 DSVECPFCD----EVSKYEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLMENEK 56 D + P+ ++ +G G FG+V +A + VA+K +L + Sbjct: 26 DPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVK-MLKPSAH 84 Query: 57 EGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL 114 + E+K+L L HEN+VNL+ C G ++ ++C DL L Sbjct: 85 STEREALMSELKVLSYLGNHENIVNLLGACTHG--------GPTLVITEYCCYGDLLNFL 136 Query: 115 SNVLVKF---------------TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 +F TL + + G+ ++ +HRD+ A N+L+T Sbjct: 137 RRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 196 Query: 160 DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 + K+ DFGLAR N N + + + PE + Y D+W G + Sbjct: 197 GNITKICDFGLARDIKNDSNYVDK--GNARLPVKWMAPESIFNS-VYTFESDVWSYGIFL 253 Query: 220 AEMWT-RSPIMQG-NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKD 277 E+++ S G + +I + +PE P Sbjct: 254 WELFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPA---------------------- 291 Query: 278 RLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 D++ DP +R + Sbjct: 292 ---------EMYDIMKTCWDADPDKRPTFKQIVQ 316 >3CJF-A nrPDB Length = 309 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 69/327 (21%), Positives = 129/327 (39%), Gaps = 62/327 (18%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKA----RHR-KTGQKVALKKVLMENEKEGF 59 YD+ + F + +G+G FG+V +A + T + VA+K +L E Sbjct: 17 YDASKWEFPR--DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVK-MLKEGATHSE 73 Query: 60 PITALREIKILQLLKHE-NVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV 117 + E+KIL + H NVVNL+ C G + ++ +FC+ +L+ L + Sbjct: 74 HRALMSELKILIHIGHHLNVVNLLGACTKPG-------GPLMVIVEFCKFGNLSTYLRSK 126 Query: 118 LVKF-----------TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLA 166 +F TL + + G+ ++ K +HRD+ A N+L++ V+K+ Sbjct: 127 RNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKIC 186 Query: 167 DFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-R 225 DFGLAR K+ R + + L + PE + +R Y D+W G ++ E+++ Sbjct: 187 DFGLARDIY--KDPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLG 243 Query: 226 SPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 + G + + + C + +Y E + + Sbjct: 244 ASPYPG------VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLD--------------- 282 Query: 286 PYALDLIDKLLVLDPAQRIDSDDALNH 312 +P+QR + + H Sbjct: 283 ---------CWHGEPSQRPTFSELVEH 300 >6E4F-A nrPDB Length = 290 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 55/246 (22%), Positives = 106/246 (43%), Gaps = 24/246 (9%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + L ++G G FG V + R VA+K + + E + E K++ Sbjct: 26 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSED---EFIEEAKVMM 81 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVM 130 L HE +V L +C + I+++ ++ L L + +F ++ + Sbjct: 82 NLSHEKLVQLYGVCTKQR--------PIFIITEYMANGCLLNYLREMRHRFQTQQLLEMC 133 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + + Y+ + LHRD+ A N L+ GV+K++DFGL+R + YT+ V Sbjct: 134 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV------LDDEYTSSVG 187 Query: 191 TL---WYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCG 246 + + PPE+L+ + + D+W G +M E+++ + T I+Q Sbjct: 188 SKFPVRWSPPEVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR 246 Query: 247 SITPEV 252 P + Sbjct: 247 LYRPHL 252 >5U6B-A nrPDB Length = 307 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 107/295 (36%), Gaps = 39/295 (13%) Query: 21 KLAKIGQGTFGEVFKARHRKTG--QKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 +G+G FG V + + + KVA+K + + L E ++ H NV Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 79 VNLIEICRTKASPYNRCKGSIYLVF----DFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 + LI +C + + + L F D L L + V + + M + Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 +G+ Y+ + +HRD+ A N ++ + + +ADFGL++ + R + + Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKM--PVKW 204 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 E L +R Y D+W G M E+ TR +P Sbjct: 205 IAIESL-ADRVYTSKSDVWSFGVTMWEIATRG-----------------------QTPYP 240 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 V+N E+Y+ L K+ Y L+ + L+P R + Sbjct: 241 GVENSEIYDYLRQGNRLKQPADCLDGLYA-------LMSRCWELNPQDRPSFTEL 288 >4C59-A nrPDB Length = 340 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 115/307 (37%), Gaps = 51/307 (16%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HE 76 + + +G F V++A+ +G++ ALK++L E++ ++E+ ++ L H Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKN--RAIIQEVCFMKKLSGHP 85 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLL 134 N+V + + L+ + C+ L L + + LS + ++ Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 135 NGLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ--------PNR 184 + ++HR K I+HRD+K N+L++ G +KL DFG A S + Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 185 YTNRVVTLWYRPPELLLGERDY--GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 R T YR PE++ ++ G D+W GCI+ + R E I Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF----EDGAKLRIV 261 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 SI P + LI +L ++P + Sbjct: 262 NGKYSIPPHD------------------------------TQYTVFHSLIRAMLQVNPEE 291 Query: 303 RIDSDDA 309 R+ + Sbjct: 292 RLSIAEV 298 >4Y93-A nrPDB Length = 446 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 51/243 (20%), Positives = 102/243 (41%), Gaps = 18/243 (7%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 + + L ++G G FG V + R VA+K + + E + E K++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSED---EFIEEAKVMM 238 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVM 130 L HE +V L +C + I+++ ++ L L + +F ++ + Sbjct: 239 NLSHEKLVQLYGVCTKQR--------PIFIITEYMANGCLLNYLREMRHRFQTQQLLEMC 290 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + + + Y+ + LHRD+ A N L+ GV+K++DFG+ R + + T Sbjct: 291 KDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYV---LDDEYTSSTGSKF 347 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 + + PE+L+ + + D+W G +M E+++ + T I+Q Sbjct: 348 PVKWASPEVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPR 406 Query: 250 PEV 252 P + Sbjct: 407 PHL 409 >5HVK-A nrPDB Length = 315 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 122/301 (40%), Gaps = 52/301 (17%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 +G+G FG+ K HR+TG+ + +K+++ +E+ T L+E+K+++ L+H NV+ I Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQ--RTFLKEVKVMRCLEHPNVLKFI 77 Query: 83 EICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIH 141 + + + ++ L G++ ++ ++ S+ + + +G+ Y+H Sbjct: 78 GVLYKDK--------RLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH 129 Query: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN----------SQPNRYTNRVVT 191 I+HR++ + N L+ + + +ADFGLAR K + V Sbjct: 130 SMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGN 189 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ PE++ G R Y +D++ G ++ E+ R + P+ Sbjct: 190 PYWMAPEMING-RSYDEKVDVFSFGIVLCEIIGRV--------------------NADPD 228 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 P ++ L + L + + LDP +R L Sbjct: 229 YLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITV---------RCCDLDPEKRPSFVK-LE 278 Query: 312 H 312 H Sbjct: 279 H 279 >3C1X-A nrPDB Length = 373 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 113/272 (41%), Gaps = 18/272 (6%) Query: 23 AKIGQGTFGEVFKARHRK-TGQKV--ALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 IG+G FG V+ G+K+ A+K + G L E I++ H NV+ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 +L+ IC R +GS +V + +H DL + N T+ ++ + G+ Sbjct: 154 SLLGICL-------RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK 206 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 ++ K +HRD+ A N ++ +K+ADFGLAR + + T + + + E Sbjct: 207 FLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALE 266 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 L ++ + D+W G ++ E+ TR P + Q + PE P+ Sbjct: 267 SLQTQK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD-- 323 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYAL 289 LYE + K +++ V A+ Sbjct: 324 --PLYEVMLKCWHPKAEMRPSFSELVSRISAI 353 >6GVJ-A nrPDB Length = 429 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 80/315 (25%), Positives = 121/315 (38%), Gaps = 54/315 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK--HE 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 ++ L + Y IY+V + DL L E K + +L Sbjct: 205 KIIRLYD--------YEITDQYIYMVMECGNIDLNSWLKKKKSIDPW-ERKSYWKNMLEA 255 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S ++V T+ Y P Sbjct: 256 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVK--DSQVGTVNYMP 312 Query: 197 PELL----------LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 PE + + P D+W GCI+ M Q + IS+L Sbjct: 313 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHA 367 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 I P ++E ++ ++D LK L DP QRI Sbjct: 368 IIDPN-----------HEIEFPDIPEKDLQDVLKC-------------CLKRDPKQRISI 403 Query: 307 DDALNHDFFWSDPMP 321 + L H + P Sbjct: 404 PELLAHPYVQIQTHP 418 >3BBT-B nrPDB Length = 328 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 121/321 (37%), Gaps = 22/321 (6%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKV----ALKKVLMENEKEGFPITALREIKILQL 72 ++ +++ +G G FG V+K G+ V A+K +L E + + E I+ Sbjct: 15 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIK-ILNETTGPKANVEFMDEALIMAS 73 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQ 131 + H ++V L+ +C + I LV H L + + Sbjct: 74 MDHPHLVRLLGVCLSPT---------IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCV 124 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + G+ Y+ +++HRD+ A NVL+ +K+ DFGLAR + N ++ Sbjct: 125 QIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLE-GDEKEYNADGGKMPI 183 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITP 250 W E + R + D+W G + E+ T G + L+ + P Sbjct: 184 KW-MALECIH-YRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 241 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 + +D Y + K ++ R L A A D + LV+ R+ Sbjct: 242 PIC-TIDVYMVMVKCWMIDADSRPKFKELAAEF-SRMARD-PQRYLVIQGDDRMKLPSPN 298 Query: 311 NHDFFWSDPMPSDLKGMLSTH 331 + FF + DL+ M+ Sbjct: 299 DSKFFQNLLDEEDLEDMMDAE 319 >4K33-A nrPDB Length = 325 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 128/316 (40%), Gaps = 45/316 (14%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK------KVLMENEKEGFP 60 + + ++ +G+G FG+V A + A K K+L ++ + Sbjct: 26 PADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL 85 Query: 61 ITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVL 118 + E+++++++ KH+N++NL+ C G +Y++ ++ + +L L Sbjct: 86 SDLVSEMEMMKMIGKHKNIINLLGACTQG--------GPLYVLVEYAAKGNLREFLRARR 137 Query: 119 ---------------VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL 163 + T ++ + G+ Y+ K +HRD+ A NVL+T D V+ Sbjct: 138 PPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 197 Query: 164 KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW 223 K+ADFGLAR + TN + + + PE L +R Y D+W G ++ E++ Sbjct: 198 KIADFGLARDVHNLDYYK--ETTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLLWEIF 254 Query: 224 T-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAY 282 T G + L+ + P ++LY + + K Sbjct: 255 TLGGSPYPGIPVEELFKLLKEGHRMDKPANC----THDLYMIMRECWHAAPSQRPTFKQL 310 Query: 283 VRDPYALDLIDKLLVL 298 V D +D++L + Sbjct: 311 VED------LDRVLTV 320 >4XLV-A nrPDB Length = 328 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 68/335 (20%), Positives = 124/335 (37%), Gaps = 67/335 (20%) Query: 5 YDSVECPFCDEVSK--YEKLAKIGQGTFGEVFK--ARHRKTGQ---KVALKKVLMENEKE 57 SV P EVS+ L ++GQG+FG V++ AR G+ +VA+K V E+ Sbjct: 25 PSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASL 83 Query: 58 GFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSN 116 I L E +++ +VV L+ + +V + H DL L + Sbjct: 84 RERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTL--------VVMELMAHGDLKSYLRS 135 Query: 117 VLVK---------FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLAD 167 + + TL E+ ++ + +G+ Y++ K +HRD+ A N ++ D +K+ D Sbjct: 136 LRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGD 195 Query: 168 FGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTR-S 226 FG+ R + ++ + + PE L + + D+W G ++ E+ + Sbjct: 196 FGMTRDIYETDYYRKG--GKGLLPVRWMAPESL-KDGVFTTSSDMWSFGVVLWEITSLAE 252 Query: 227 PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDP 286 QG + + L + P+ P Sbjct: 253 QPYQGLSNEQVLKFVMDGGYLDQPDNCP-------------------------------E 281 Query: 287 YALDLIDKLLVLDPAQRIDSDDALN------HDFF 315 DL+ +P R + +N H F Sbjct: 282 RVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSF 316 >2HK5-A nrPDB Length = 270 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 121/285 (42%), Gaps = 25/285 (8%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D+ E P + K+G G FGEV+ A + K KVA+K + + L Sbjct: 8 DAWEIP----RESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS---VEAFLA 59 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLL-SNVLVKFTL 123 E +++ L+H+ +V L + K IY++ +F + L L S+ K L Sbjct: 60 EANVMKTLQHDKLVKLHAVV---------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPL 110 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + G+ +I + +HRD++AAN+L++ V K+ADFGLAR N Sbjct: 111 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE--DNEYTA 168 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 R + W P + G + D+W G ++ E+ T G + + + Sbjct: 169 REGAKFPIKWTAPEAINFGS--FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 226 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPY 287 + PE P + Y + + + ++R + +++ + D Sbjct: 227 RGYRMPRPENCPE-ELYNIMMRCWKNRPEERPTFEYIQSVLDDFE 270 >1U59-A nrPDB Length = 287 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 58/235 (24%), Positives = 96/235 (40%), Gaps = 16/235 (6%) Query: 24 KIGQGTFGEVFKA--RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 ++G G FG V + R RK VA+K + EK +RE +I+ L + +V L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 75 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 I +C+ +A + LV + L L + +S + ++ + G+ Y+ Sbjct: 76 IGVCQAEA---------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 126 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 +HRD+ A NVL+ K++DFGL++A + R + WY PE + Sbjct: 127 EEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI 185 Query: 201 LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWP 254 R + D+W G M E + + +A I Q P P Sbjct: 186 -NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 239 >5TQX-A nrPDB Length = 655 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 75/357 (21%), Positives = 132/357 (36%), Gaps = 28/357 (7%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 P +E ++G G FG V +HR+ K+A+K +E + EI+I+ Sbjct: 2 PEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIM 60 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV--KFTLSEIK 127 + L H NVV C L ++C DL LL+ S+I Sbjct: 61 KKLNHANVVK---ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQIL 117 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQPNR 184 ++ + +G+ Y+H NKI+HRD+K N+++ G + K+ D G A+ Q Sbjct: 118 SLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVD-----QGEL 172 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 T V TL Y PE L + Y +D W G ++ E + + + Sbjct: 173 CTEFVGTLQYLAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKK 231 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 + + + L + + +P + + +L DP QR Sbjct: 232 KDPKCIFACEEMSGEVRF-------SSHLPQPNSLCSLIVEPM-ENWLQLMLNWDPQQRG 283 Query: 305 DSDDA-LNHD--FFWSDPMPS-DLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQS 357 D L F D + + + +L+ + +L PP + + ++ Sbjct: 284 GPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERET 340 >3LLT-A nrPDB Length = 360 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 70/338 (20%), Positives = 130/338 (38%), Gaps = 54/338 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + + K+G GTFG V +H + A+K V + + +A E IL+ ++ Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQ---N 90 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRVMQMLLNGL 137 ++ K + L+F+ L ++ N F + +IK +L L Sbjct: 91 DDINNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKAL 150 Query: 138 YYIHRNKILHRDMKAANVLITRDGV-------------------------LKLADFGLAR 172 Y+ + + H D+K N+L+ +KL DFG A Sbjct: 151 NYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT 210 Query: 173 AFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 + + + + + T YR PE++L + D+W GC++AE++T S + + + Sbjct: 211 -------FKSDYHGSIINTRQYRAPEVILN-LGWDVSSDMWSFGCVLAELYTGSLLFRTH 262 Query: 233 TEQHQLALISQLCGSITPEVW-----PNVDNYELYEKLELVKGQK-------RKVKDRLK 280 LA++ + I + N Y ++L+L + + VK L Sbjct: 263 EHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLP 322 Query: 281 AY--VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 Y ++ D + +L +DP R + L H F Sbjct: 323 LYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4HZS-A nrPDB Length = 341 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 107/280 (38%), Gaps = 19/280 (6%) Query: 18 KYEKLAKIGQGTFGEVFKARH-RKTGQKV--ALKKVLME-NEKEGFPITALREIKILQLL 73 L K+G G+FG V + +G+ V A+K + + + +RE+ + L Sbjct: 13 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 72 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQM 132 H N++ L + T + +V + L L F L + R Sbjct: 73 DHRNLIRLYGVVLTP---------PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQ 123 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + G+ Y+ + +HRD+ A N+L+ ++K+ DFGL RA + + +V Sbjct: 124 VAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVP-F 182 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI-SQLCGSITP 250 + PE L R + D W G + EM+T G L I + P Sbjct: 183 AWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRP 241 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 E P D Y + + K + R L+ ++ + D Sbjct: 242 EDCP-QDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 280 >4OTD-A nrPDB Length = 341 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 71/360 (19%), Positives = 137/360 (38%), Gaps = 70/360 (19%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKILQLL- 73 + ++ LA +G+G FG+V + R +G+ A+K + + + +L E +IL + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 74 --KHENVVNLIEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKFTLSEIKRVM 130 H +VNL +T + V ++ DL +L F+ Sbjct: 71 SAGHPFLVNLFGCFQTPE--------HVCFVMEYSAGGDL--MLHIHSDVFSEPRAIFYS 120 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 ++ GL ++H +KI++RD+K N+L+ +G +K+ADFGL + +R + Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKE----GMGYGDRTSTFCG 176 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T + PE+L + Y +D WG G ++ EM G+ E+ I Sbjct: 177 TPEFLAPEVL-TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN------- 228 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----D 305 + A+ ++ +LL +P +R+ D Sbjct: 229 -------------------------DEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERD 263 Query: 306 SDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365 ++D FF + + L L PP ++ ++ + + T + Sbjct: 264 AEDVKKQPFFRTLGWEALLARRLP-----------PPF--VPTLSGRTDVSNFDEEFTGE 310 >4UY9-A nrPDB Length = 323 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 109/276 (39%), Gaps = 37/276 (13%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP--ITALREIKILQL 72 + ++ IG G FG+V++A G +VA+K + +++ +E K+ + Sbjct: 7 DFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 64 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVM 130 LKH N++ L +C + ++ LV +F G L+ VL + + Sbjct: 65 LKHPNIIALRGVC--------LKEPNLCLVMEFAR---GGPLNRVLSGKRIPPDILVNWA 113 Query: 131 QMLLNGLYYIHRNK---ILHRDMKAANVLITR--------DGVLKLADFGLARAFSLAKN 179 + G+ Y+H I+HRD+K++N+LI + + +LK+ DFGLAR + Sbjct: 114 VQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH---- 169 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 + T + PE++ + D+W G ++ E+ T +G Sbjct: 170 --RTTKMSAAGTYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAY 226 Query: 240 LI-SQLCGSITPEVWPNVDNYELYEKLELVKGQKRK 274 + P P +L E R Sbjct: 227 GVAMNKLALPIPSTCPEPF-AKLMEDCWNPDPHSRP 261 >3PP0-A nrPDB Length = 338 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 109/292 (37%), Gaps = 30/292 (10%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKV----ALKKVLMENEKEGFPITALREIKILQL 72 ++ K+ +G G FG V+K G+ V A+K VL EN L E ++ Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIK-VLRENTSPKANKEILDEAYVMAG 75 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQ 131 + V L+ IC T + LV + L + + ++ Sbjct: 76 VGSPYVSRLLGICLTST---------VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCM 126 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + G+ Y+ +++HRD+ A NVL+ +K+ DFGLAR + + +V Sbjct: 127 QIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPI 185 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITP 250 W +L R + D+W G + E+ T + G + L+ + P Sbjct: 186 KWMALESIL--RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQP 243 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + +D Y + K ++ + R L + ++ DP + Sbjct: 244 PIC-TIDVYMIMVKCWMIDSECRPRFRELVSEF---------SRM-ARDPQR 284 >5B2L-A nrPDB Length = 324 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 61/327 (18%), Positives = 115/327 (35%), Gaps = 49/327 (14%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 E++ E L ++G GT G+V+K R RKTG +A+K++ KE + +L+ Sbjct: 15 EINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHD 74 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 +V T +++ + L + + ++ ++ Sbjct: 75 CPYIVQCFGTFITNTD--------VFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIV 126 Query: 135 NGLYYI-HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 LYY+ ++ ++HRD+K +N+L+ G +KL DFG++ +K T Sbjct: 127 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK-----TRSAGCAA 181 Query: 194 YRPPELLL----GERDYGPPIDLWGAGCIMAEMWTRSPIMQG-NTEQHQLALISQLCGSI 248 Y PE + + DY D+W G + E+ T + T+ L + Q Sbjct: 182 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ----E 237 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 P + P + + L D +R + Sbjct: 238 EPPLLPGHMGF-------------------------SGDFQSFVKDCLTKDHRKRPKYNK 272 Query: 309 ALNHDFFW-SDPMPSDLKGMLSTHLTS 334 L H F + + D+ + Sbjct: 273 LLEHSFIKRYETLEVDVASWFKDVMAK 299 >5AP3-A nrPDB Length = 313 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 122/315 (38%), Gaps = 54/315 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK--HE 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 ++ L + Y IY+V + DL G L E K + +L Sbjct: 89 KIIRLYD--------YEITDQYIYMVMECGNIDLNGWLKKKKSIDPW-ERKSYWKNMLEA 139 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S ++V T+ Y P Sbjct: 140 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVK--DSQVGTVNYMP 196 Query: 197 PELL----------LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 PE + + P D+W GCI+ M Q + IS+L Sbjct: 197 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHA 251 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 I P ++E ++ ++D LK L DP QRI Sbjct: 252 IIDPN-----------HEIEFPDIPEKDLQDVLKC-------------CLKRDPKQRISI 287 Query: 307 DDALNHDFFWSDPMP 321 + L H + P Sbjct: 288 PELLAHPYVQIQTHP 302 >2OZO-A nrPDB Length = 613 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 57/235 (24%), Positives = 96/235 (40%), Gaps = 16/235 (6%) Query: 24 KIGQGTFGEVFKA--RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 ++G G FG V + R RK VA+K + EK +RE +I+ L + +V L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 I +C+ +A + LV + L L + +S + ++ + G+ Y+ Sbjct: 402 IGVCQAEA---------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 +HR++ A NVL+ K++DFGL++A + R + WY PE + Sbjct: 453 EEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI 511 Query: 201 LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWP 254 R + D+W G M E + + +A I Q P P Sbjct: 512 -NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 >5UIU-A nrPDB Length = 323 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 120/296 (40%), Gaps = 39/296 (13%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKV--LMENEKEGFPITALREIKILQLLKHENVVNL 81 K+G+G FG V+K T VA+KK+ +++ E +EIK++ +HEN+V L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLS--NVLVKFTLSEIKRVMQMLLNGLY 138 + ++ + LV+ + L LS + + ++ Q NG+ Sbjct: 112 LG--------FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN 163 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 ++H N +HRD+K+AN+L+ K++DFGLARA K +Q + V T Y PE Sbjct: 164 FLHENHHIHRDIKSANILLDEAFTAKISDFGLARA--SEKFAQTVMTSRIVGTTAYMAPE 221 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 L GE P D++ G ++ E+ T P + + E L I + + +D Sbjct: 222 ALRGE--ITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDK 279 Query: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD---DALN 311 K D A + L +R D L Sbjct: 280 -------------KMNDADSTSVEAMYSVA----SQCLHEKKNKRPDIKKVQQLLQ 318 >3Q4U-A nrPDB Length = 301 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 127/304 (41%), Gaps = 37/304 (12%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 L +G+G +GEV++ + G+ VA+K +EK F T E+ +L+HEN Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRET---ELYNTVMLRHEN 63 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVMQMLLN 135 ++ I T ++L+ + E G L + L TL + R++ + + Sbjct: 64 ILGFIASDMTSRH----SSTQLWLITHYHEM---GSLYDYLQLTTLDTVSCLRIVLSIAS 116 Query: 136 GLYYIH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 GL ++H + I HRD+K+ N+L+ ++G +AD GLA S + N Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 188 RVVTLWYRPPELLLGERDYG-----PPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 RV T Y PE+L +D+W G ++ E+ R I Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRM----------VSNGIV 226 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 + +V PN ++E K+ V Q+ + +R + L+ + +P+ Sbjct: 227 EDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSA 286 Query: 303 RIDS 306 R+ + Sbjct: 287 RLTA 290 >6B2Q-A nrPDB Length = 317 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 51/217 (23%), Positives = 93/217 (42%), Gaps = 8/217 (3%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE-GFPITALREIKILQLLKH 75 +Y I G G+V++A + G++VA+K + E + F E + +L H Sbjct: 32 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 91 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 + ++ + ++ + R YLV + + + + +L +++ Sbjct: 92 PGIASVHDYGESQMNGEGRTA---YLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 148 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L H ++HRD+K N+LIT G +K+ DFG+A+A A +Q + T Y Sbjct: 149 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV---MGTAQYI 205 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 PE LG D P D++ G + E + G+ Sbjct: 206 APEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 51/217 (23%), Positives = 93/217 (42%), Gaps = 8/217 (3%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE-GFPITALREIKILQLLKH 75 +Y I G G+V++A + G++VA+K + E + F E + +L H Sbjct: 12 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 71 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 + ++ + ++ + R YLV + + + + +L +++ Sbjct: 72 PGIASVHDYGESQMNGEGRTA---YLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 128 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L H ++HRD+K N+LIT G +K+ DFG+A+A A +Q + T Y Sbjct: 129 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV---MGTAQYI 185 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 PE LG D P D++ G + E + G+ Sbjct: 186 APEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 51/217 (23%), Positives = 93/217 (42%), Gaps = 8/217 (3%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE-GFPITALREIKILQLLKH 75 +Y I G G+V++A + G++VA+K + E + F E + +L H Sbjct: 11 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 70 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 + ++ + ++ + R YLV + + + + +L +++ Sbjct: 71 PGIASVHDYGESQMNGEGRTA---YLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGR 127 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 L H ++HRD+K N+LIT G +K+ DFG+A+A A +Q + T Y Sbjct: 128 ALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV---MGTAQYI 184 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGN 232 PE LG D P D++ G + E + G+ Sbjct: 185 APEQALG-HDASPASDVYSLGVVGYEAVSGKRPFAGD 220 >5EG3-A nrPDB Length = 334 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 127/311 (40%), Gaps = 43/311 (13%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKA----RHRKTGQK---VALKKVLMENEKEGFPITAL 64 + K +G+G FG+V A + ++ VA+K +L ++ E + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVK-MLKDDATEKDLSDLV 88 Query: 65 REIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVL---- 118 E+++++++ KH+N++NL+ C G +Y++ + +L L Sbjct: 89 SEMEMMKMIGKHKNIINLLGACTQD--------GPLYVIVAYASKGNLREYLRARRPPGM 140 Query: 119 -----------VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLAD 167 + T ++ L G+ Y+ K +HRD+ A NVL+T + V+K+AD Sbjct: 141 ELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 200 Query: 168 FGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RS 226 FGLAR + + TN + + + PE L +R Y D+W G +M E++T Sbjct: 201 FGLARDINNIDFFK--ETTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGG 257 Query: 227 PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVK------DRLK 280 G + L+ + P N + + V Q+ K DR+ Sbjct: 258 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 317 Query: 281 AYVRDPYALDL 291 + LDL Sbjct: 318 TLTTNEEYLDL 328 >4UYA-A nrPDB Length = 340 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 117/302 (38%), Gaps = 42/302 (13%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE--GFPI 61 Q V F + E IG G FG+V++A + GQ+VA+K + E++ Sbjct: 17 QGSPVHVAF----ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAE 70 Query: 62 TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--V 119 + RE ++ +L+H N++ L +C + + LV +F G L+ L Sbjct: 71 SVRREARLFAMLRHPNIIELRGVCLQQP--------HLCLVLEFAR---GGALNRALAGR 119 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNK---ILHRDMKAANVLITR--------DGVLKLADF 168 + + + G+ Y+H ILHRD+K++N+L+ + LK+ DF Sbjct: 120 RIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 179 Query: 169 GLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 GLAR + + PE++ + D+W G ++ E+ T Sbjct: 180 GLAREWH------RTTKMATAGAYAWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVP 232 Query: 229 MQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYA 288 +G ++ ++ P+ + ++ Q ++ + A Sbjct: 233 YRGIDGLAVAYGVAVNKLTLP---IPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTA 289 Query: 289 LD 290 ++ Sbjct: 290 IE 291 >6FEX-A nrPDB Length = 321 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 60/328 (18%), Positives = 123/328 (37%), Gaps = 59/328 (17%) Query: 15 EVSKYEKLAKIGQGTFGEVFKAR--------------HRKTGQ--KVALKKVLMENEKEG 58 S+ K+G+G FGEV + + G VA+K +L + + Sbjct: 14 PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVK-ILRPDATKN 72 Query: 59 FPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV 117 L+E+KI+ LK N++ L+ +C + ++ D+ E DL LS Sbjct: 73 ARNDFLKEVKIMSRLKDPNIIRLLGVCVQD--------DPLCMITDYMENGDLNQFLSAH 124 Query: 118 LVK------------FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKL 165 ++ + + V + +G+ Y+ +HRD+ N L+ + +K+ Sbjct: 125 QLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI 184 Query: 166 ADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAE--MW 223 ADFG++R + V+ + + E +L + + D+W G + E M Sbjct: 185 ADFGMSRNLYAGDYYRVQ--GRAVLPIRWMAWECILMGK-FTTASDVWAFGVTLWEVLML 241 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 R+ T++ + + +V+ + EL+ + ++ + Sbjct: 242 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 301 Query: 284 RDPYALDLIDKLLVLDPAQRIDSDDALN 311 + + + L ++DALN Sbjct: 302 Q-------LHRFL---------AEDALN 313 >3HMP-A nrPDB Length = 342 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 80/315 (25%), Positives = 121/315 (38%), Gaps = 54/315 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK--HE 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 ++ L + Y IY+V + DL L E K + +L Sbjct: 117 KIIRLYD--------YEITDQYIYMVMECGNIDLNSWLKKKKSIDPW-ERKSYWKNMLEA 167 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S ++V T+ Y P Sbjct: 168 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVK--DSQVGTVNYMP 224 Query: 197 PELL----------LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 PE + + P D+W GCI+ M Q + IS+L Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHA 279 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 I P ++E ++ ++D LK L DP QRI Sbjct: 280 IIDPN-----------HEIEFPDIPEKDLQDVLKC-------------CLKRDPKQRISI 315 Query: 307 DDALNHDFFWSDPMP 321 + L H + P Sbjct: 316 PELLAHPYVQIQTHP 330 >1U54-B nrPDB Length = 291 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 62/280 (22%), Positives = 107/280 (38%), Gaps = 19/280 (6%) Query: 18 KYEKLAKIGQGTFGEVFKARH-RKTGQKV--ALKKVLME-NEKEGFPITALREIKILQLL 73 L K+G G+FG V + +G+ V A+K + + + +RE+ + L Sbjct: 19 DLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSL 78 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQM 132 H N++ L + T + +V + L L F L + R Sbjct: 79 DHRNLIRLYGVVLTP---------PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQ 129 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTL 192 + G+ Y+ + +HRD+ A N+L+ ++K+ DFGL RA + + +V Sbjct: 130 VAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVP-F 188 Query: 193 WYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALI-SQLCGSITP 250 + PE L R + D W G + EM+T G L I + P Sbjct: 189 AWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRP 247 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 E P D Y + + K + R L+ ++ + D Sbjct: 248 EDCP-QDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 286 >6BSD-A nrPDB Length = 876 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 60/334 (17%), Positives = 123/334 (36%), Gaps = 65/334 (19%) Query: 15 EVSKYEKLAKIGQGTFGEVFKAR--------------HRKTGQ--KVALKKVLMENEKEG 58 S+ K+G+G FGEV + + G VA+K +L + + Sbjct: 569 PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVK-ILRPDATKN 627 Query: 59 FPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV 117 L+E+KI+ LK N++ L+ +C + ++ D+ E DL LS Sbjct: 628 ARNDFLKEVKIMSRLKDPNIIRLLGVCVQD--------DPLCMITDYMENGDLNQFLSAH 679 Query: 118 LVK------------------FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 ++ + + V + +G+ Y+ +HRD+ N L+ Sbjct: 680 QLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE 739 Query: 160 DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 + +K+ADFG++R + V+ + + E +L + + D+W G + Sbjct: 740 NFTIKIADFGMSRNLYAGDYYRVQ--GRAVLPIRWMAWECILMGK-FTTASDVWAFGVTL 796 Query: 220 AE--MWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKD 277 E M R+ T++ + + +V+ + EL+ + + Sbjct: 797 WEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESE 856 Query: 278 RLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + + + + + L ++DALN Sbjct: 857 QRPPFSQ-------LHRFL---------AEDALN 874 >3DTC-A nrPDB Length = 271 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 108/276 (39%), Gaps = 37/276 (13%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP--ITALREIKILQL 72 + ++ IG G FG+V++A G +VA+K + +++ +E K+ + Sbjct: 5 DFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAM 62 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL--VKFTLSEIKRVM 130 LKH N++ L +C + ++ LV +F G L+ VL + + Sbjct: 63 LKHPNIIALRGVC--------LKEPNLCLVMEFAR---GGPLNRVLSGKRIPPDILVNWA 111 Query: 131 QMLLNGLYYIHRNK---ILHRDMKAANVLITR--------DGVLKLADFGLARAFSLAKN 179 + G+ Y+H I+HRD+K++N+LI + + +LK+ DFGLAR + Sbjct: 112 VQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH---- 167 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLA 239 + + PE++ + D+W G ++ E+ T +G Sbjct: 168 --RTTKMSAAGAYAWMAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAY 224 Query: 240 LI-SQLCGSITPEVWPNVDNYELYEKLELVKGQKRK 274 + P P +L E R Sbjct: 225 GVAMNKLALPIPSTCPEPF-AKLMEDCWNPDPHSRP 259 >4PL5-B nrPDB Length = 435 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 76/351 (21%), Positives = 135/351 (38%), Gaps = 61/351 (17%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKI--------GQGTFGE-VFKARHRKTGQKVALKKVL 51 M ++ S+E DE ++ + KI G G G V+K + VA+K++L Sbjct: 3 MDPEFPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKGMF--DNRDVAVKRIL 60 Query: 52 MENEKEGFPITALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL 110 E A RE+++L+ H NV+ C K + Y+ + C L Sbjct: 61 PEC-----FSFADREVQLLRESDEHPNVIRYF--CTEKDRQFQ------YIAIELCAATL 107 Query: 111 AGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI---TRDGVLK--L 165 + E ++ +GL ++H I+HRD+K N+L+ G +K + Sbjct: 108 QEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMI 167 Query: 166 ADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY--GPPIDLWGAGCIMAEMW 223 +DFGL + ++ ++S +R + T + PE+L + +D++ AGC+ + Sbjct: 168 SDFGLCKKLAVGRHSF-SRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVI 226 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 + G + Q Q ++ C Sbjct: 227 SEGYHPFGKSLQRQANILLGACNLDCFH----------------------------SDKH 258 Query: 284 RDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTS 334 D A +LI+K++ +DP QR + L H FFWS +S + Sbjct: 259 EDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEK 309 >6HV0-A nrPDB Length = 416 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 69/321 (21%), Positives = 124/321 (38%), Gaps = 53/321 (16%) Query: 23 AKIGQGTFGE-VFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVN 80 +G G G V++ + VA+K++L E A RE+++L+ H NV+ Sbjct: 14 DVLGHGAEGTIVYRGMF--DNRDVAVKRILPEC-----FSFADREVQLLRESDEHPNVIR 66 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 C K + Y+ + C L + E ++Q +GL ++ Sbjct: 67 YF--CTEKDRQFQ------YIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHL 118 Query: 141 HRNKILHRDMKAANVLI---TRDGVLK--LADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 H I+HRD+K N+LI G +K ++DFGL + ++ ++S +R + T + Sbjct: 119 HSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSF-SRRSGVPGTEGWI 177 Query: 196 PPELLLGERDY--GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 PE+L + +D++ AGC+ + + G + Q Q ++ C Sbjct: 178 APEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLH-- 235 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 D A +LI+K++ +DP +R + L H Sbjct: 236 --------------------------PEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHP 269 Query: 314 FFWSDPMPSDLKGMLSTHLTS 334 FFWS +S + Sbjct: 270 FFWSLEKQLQFFQDVSDRIEK 290 >5O0Y-A nrPDB Length = 579 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 113/303 (37%), Gaps = 49/303 (16%) Query: 30 FGEVFKARHRKTGQKVALK-----KVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 F EV+KA + VA+K K + +KE + A RE +I + L H +V L + Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNK 144 + S V ++CE + + E + ++ ++N L Y++ K Sbjct: 357 F-------SLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIK 409 Query: 145 --ILHRDMKAANVLI---TRDGVLKLADFGLARAFSLAKNSQPNRY---TNRVVTLWYRP 196 I+H D+K N+L+ T G +K+ DFGL++ + + + T WY P Sbjct: 410 PPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLP 469 Query: 197 PELLLGER---DYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 PE + + +D+W G I + G+ + Q Sbjct: 470 PECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ---------------- 512 Query: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 ++ ++ ++K + + + V P A I + L RID Sbjct: 513 ------DILQENTILKATEVQFPPK---PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDP 563 Query: 314 FFW 316 + Sbjct: 564 YLL 566 >4H1J-A nrPDB Length = 293 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 99/287 (34%), Gaps = 50/287 (17%) Query: 23 AKIGQGTFGEVFKAR---HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 +G+G FGEV++ H+ VA+K + + + E I++ L H ++V Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIV 88 Query: 80 NLIEICRTKASPYNRCKGSIYLVFD-FCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 LI I + + +++ + + +L L + + + + Sbjct: 89 KLIGIIEEEPT---------WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 139 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Y+ +HRD+ N+L+ +KL DFGL+R + + + + + PE Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKA---SVTRLPIKWMSPE 196 Query: 199 LLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 + R + D+W M E+ + + + ++ + P++ P Sbjct: 197 SI-NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP--- 252 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 P L+ + DP+ R Sbjct: 253 ----------------------------PVLYTLMTRCWDYDPSDRP 271 >5GNK-A nrPDB Length = 297 Score = 180 bits (458), Expect = 7e-46, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 111/294 (37%), Gaps = 22/294 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKV----ALKKVLMENEKEGFPITALREIKILQL 72 ++++K+ +G G FG V+K G+KV A+K++ E L E ++ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMAS 77 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQ 131 + + +V L+ IC T + L+ L + + Sbjct: 78 VDNPHVCRLLGICLTST---------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCV 128 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + G+ Y+ +++HRD+ A NVL+ +K+ DFGLA+ + +V Sbjct: 129 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPI 187 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITP 250 W +L R Y D+W G + E+ T S G +++ + P Sbjct: 188 KWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQP 245 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 + +D Y + K ++ R L A D + LV+ +R+ Sbjct: 246 PIC-TIDVYMIMVKCWMIDADSRPKFRELIIEF-SKMARD-PQRYLVIQGDERM 296 >5VD3-A nrPDB Length = 311 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 105/294 (35%), Gaps = 49/294 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-KHEN 77 +++L+++G G++GEVFK R ++ G+ A+K+ + L E+ + + +H Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 V L + G +YL + C L +++ ++ L L Sbjct: 119 CVRLEQAWEEG--------GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLAL 170 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 ++H ++H D+K AN+ + G KL DFGL A + Y P Sbjct: 171 AHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE-----GDPRYMAP 225 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 ELL G YG D++ G + E+ + G QL G + PE Sbjct: 226 ELLQGS--YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-----GYLPPEF----- 273 Query: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 ++ +L DP R ++ L Sbjct: 274 -----------------------TAGLSSELRSVLVMMLEPDPKLRATAEALLA 304 >2OGV-A nrPDB Length = 317 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 121/306 (39%), Gaps = 33/306 (10%) Query: 6 DSVECPFCD----EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-----KVALKKVLMENEK 56 D + P+ + + + +G G FG+V +A G+ KVA+K +L Sbjct: 23 DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK-MLKSTAH 81 Query: 57 EGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL 114 + E+KI+ L +HEN+VNL+ C G + ++ ++C DL L Sbjct: 82 ADEKEALMSELKIMSHLGQHENIVNLLGACTHG--------GPVLVITEYCCYGDLLNFL 133 Query: 115 SNVL---------VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKL 165 L ++ + G+ ++ +HRD+ A NVL+T V K+ Sbjct: 134 RRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKI 193 Query: 166 ADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT- 224 DFGLAR N N + + + PE + + Y D+W G ++ E+++ Sbjct: 194 GDFGLARDIMNDSNYIVK--GNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSL 250 Query: 225 RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR 284 G + + + + + + Y + + ++ R ++ ++++ Sbjct: 251 GLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 310 Query: 285 DPYALD 290 + D Sbjct: 311 EQAQED 316 >4YHJ-A nrPDB Length = 584 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 117/307 (38%), Gaps = 50/307 (16%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF-PITALREIKILQLLKHEN 77 + +G+G FGEV + R TG+ A KK+ + K+ AL E +IL+ ++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVL-VKFTLSEIKRVMQMLLN 135 VV+L T K ++ LV DL + N+ F L Sbjct: 247 VVSLAYAYET--------KDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 298 Query: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 GL + R +I++RD+K N+L+ G ++++D GLA + R RV T+ Y Sbjct: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIP-----EGQRVRGRVGTVGYM 353 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE++ E+ Y D WG GC++ EM + E+ + + Q + T E Sbjct: 354 APEVVNNEK-YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI-----DSDDAL 310 A + LL +P++R+ + Sbjct: 413 F----------------------------SEDAKSICRMLLTKNPSKRLGCRGEGAAGVK 444 Query: 311 NHDFFWS 317 H F Sbjct: 445 QHPVFKD 451 >1K9A-A nrPDB Length = 450 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 66/318 (20%), Positives = 123/318 (38%), Gaps = 58/318 (18%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 +A Q + + + + + L IG+G FG+V +R G KVA+K + + + F Sbjct: 177 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF- 233 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLV 119 L E ++ L+H N+V L+ + + KG +Y+V ++ + L L + Sbjct: 234 ---LAEASVMTQLRHSNLVQLLGVIVEE-------KGGLYIVTEYMAKGSLVDYLRSRGR 283 Query: 120 K-FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + + + Y+ N +HRD+ A NVL++ D V K++DFGL + S + Sbjct: 284 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 343 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQ 237 + T ++ W PE L E+ + D+W G ++ E+++ + Sbjct: 344 D------TGKLPVKWT-APEALR-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 395 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 + + + P+ P P D++ Sbjct: 396 VPRVEKGYKMDAPDGCP-------------------------------PAVYDVMKNCWH 424 Query: 298 LDPAQRIDSDDA---LNH 312 LD A R L H Sbjct: 425 LDAATRPTFLQLREQLEH 442 >3SXS-A nrPDB Length = 268 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 110/272 (40%), Gaps = 24/272 (8%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 + + L ++G G FG V + + VA+K + + E +E + + L Sbjct: 6 KREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMSED---EFFQEAQTMMKLS 61 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQML 133 H +V +C + IY+V ++ + L L + S++ + + Sbjct: 62 HPKLVKFYGVC--------SKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDV 113 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ ++ ++ +HRD+ A N L+ RD +K++DFG+ R ++Y + V T + Sbjct: 114 CEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV------LDDQYVSSVGTKF 167 Query: 194 ---YRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSIT 249 + PE+ + Y D+W G +M E+++ T + +SQ Sbjct: 168 PVKWSAPEVFHYFK-YSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYR 226 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKA 281 P + + +Y + ++ + L + Sbjct: 227 PHLASDTIYQIMYSCWHELPEKRPTFQQLLSS 258 >3LZB-A nrPDB Length = 327 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 110/295 (37%), Gaps = 36/295 (12%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKV----ALKKVLMENEKEGFPITALREIKILQL 72 ++++K+ +G G FG V+K G+KV A+K++ E L E ++ Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMAS 73 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQ 131 + + +V L+ IC T + L+ L + + Sbjct: 74 VDNPHVCRLLGICLTST---------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV 124 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + G+ Y+ +++HRD+ A NVL+ +K+ DFGLA+ + +V Sbjct: 125 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPI 183 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITP 250 W +L R Y D+W G + E+ T S G +++ + P Sbjct: 184 KWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQP 241 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLI---DKLLVLDPAQ 302 + +D Y + K ++ R P +LI K+ DP + Sbjct: 242 PIC-TIDVYMIMRKCWMIDADSR------------PKFRELIIEFSKM-ARDPQR 282 >2ZMD-A nrPDB Length = 390 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 120/315 (38%), Gaps = 54/315 (17%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK--HE 76 Y L +IG G +VF+ + K Q A+K V +E + EI L L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 ++ L + Y IY+V + DL L E K + +L Sbjct: 117 KIIRLYD--------YEITDQYIYMVMECGNIDLNSWLKKKKSIDPW-ERKSYWKNMLEA 167 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 ++ IH++ I+H D+K AN LI DG+LKL DFG+A S ++V + Y P Sbjct: 168 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVK--DSQVGAVNYMP 224 Query: 197 PELL----------LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 PE + + P D+W GCI+ M Q + IS+L Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHA 279 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 I P ++E ++ ++D LK L DP QRI Sbjct: 280 IIDPN-----------HEIEFPDIPEKDLQDVLKC-------------CLKRDPKQRISI 315 Query: 307 DDALNHDFFWSDPMP 321 + L H + P Sbjct: 316 PELLAHPYVQIQTHP 330 >1FVR-A nrPDB Length = 327 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 121/327 (37%), Gaps = 67/327 (20%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKV--ALKKVLMENEKEGFPI 61 D P D + + IG+G FG+V KAR +K G ++ A+K++ E + Sbjct: 13 NPDPTIYPVLD-WNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRM-KEYASKDDHR 70 Query: 62 TALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLV 119 E+++L L H N++NL+ C +G +YL ++ H +L L V Sbjct: 71 DFAGELEVLCKLGHHPNIINLLGACEH--------RGYLYLAIEYAPHGNLLDFLRKSRV 122 Query: 120 ---------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLK 164 + ++ + G+ Y+ + + +HRD+ A N+L+ + V K Sbjct: 123 LETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAK 182 Query: 165 LADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT 224 +ADFGL+R + + R+ W E L Y D+W G ++ E+ + Sbjct: 183 IADFGLSR----GQEVYVKKTMGRLPVRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVS 236 Query: 225 -RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 G + ELYEKL + K Sbjct: 237 LGGTPYCG------------------------MTCAELYEKL-------PQGYRLEKPLN 265 Query: 284 RDPYALDLIDKLLVLDPAQRIDSDDAL 310 D DL+ + P +R L Sbjct: 266 CDDEVYDLMRQCWREKPYERPSFAQIL 292 >3PLS-A nrPDB Length = 298 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 112/290 (38%), Gaps = 18/290 (6%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRK---TGQKVALKKVLMENEKEGFP 60 + V P V+ IG+G FG V+ + + A+K + E + Sbjct: 10 EVKDVLIPHERVVT--HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV- 66 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 LRE +++ L H NV+ LI I + + C DL + + Sbjct: 67 EAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYM------CHGDLLQFIRSPQRN 120 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 T+ ++ + G+ Y+ K +HRD+ A N ++ +K+ADFGLAR + Sbjct: 121 PTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYY 180 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLA 239 ++ + + + + E L R + D+W G ++ E+ TR P + Sbjct: 181 SVQQHRHARLPVKWTALESLQTYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTH 239 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL 289 ++Q PE P+ LY+ ++ V+ + V + + Sbjct: 240 FLAQGRRLPQPEYCPD----SLYQVMQQCWEADPAVRPTFRVLVGEVEQI 285 >3BEA-A nrPDB Length = 333 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 121/310 (39%), Gaps = 37/310 (11%) Query: 6 DSVECPFCD----EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-----KVALKKVLMENEK 56 D + P+ + + + +G G FG+V +A G+ KVA+K +L Sbjct: 31 DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK-MLKSTAH 89 Query: 57 EGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL 114 + E+KI+ L +HEN+VNL+ C G + ++ ++C DL L Sbjct: 90 ADEKEALMSELKIMSHLGQHENIVNLLGACTHG--------GPVLVITEYCCYGDLLNFL 141 Query: 115 SNVLV-------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG 161 + ++ + G+ ++ +HRD+ A NVL+T Sbjct: 142 RRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH 201 Query: 162 VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAE 221 V K+ DFGLAR N N + + + PE + + Y D+W G ++ E Sbjct: 202 VAKIGDFGLARDIMNDSNYIVK--GNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWE 258 Query: 222 MWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLK 280 +++ G + + + + + + Y + + ++ R ++ Sbjct: 259 IFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQIC 318 Query: 281 AYVRDPYALD 290 +++++ D Sbjct: 319 SFLQEQAQED 328 >2A1A-B nrPDB Length = 284 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 124/307 (40%), Gaps = 64/307 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 ++++ IG G FG+VFKA+HR G+ +K+V NEK A RE+K L L H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVN 65 Query: 78 VVNLIEIC--------RTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 +V+ + + +++ +FC+ G L + K ++ +V Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCD---KGTLEQWIEKRRGEKLDKV 122 Query: 130 MQ-----MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR 184 + + G+ YIH K+++RD+K +N+ + +K+ DFGL + + Sbjct: 123 LALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKND-----GK 177 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 T TL Y PE + +DYG +DL+ G I+AE+ Sbjct: 178 RTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL--------------------- 215 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 + + ++D + + + D L+ KLL P R Sbjct: 216 ---------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRP 260 Query: 305 DSDDALN 311 ++ + L Sbjct: 261 NTSEILR 267 >1BYG-A nrPDB Length = 278 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 125/294 (42%), Gaps = 25/294 (8%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 +A Q + + + + + L IG+G FG+V +R G KVA+K + + + F Sbjct: 5 VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF- 61 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLV 119 L E ++ L+H N+V L+ + + KG +Y+V ++ + L L + Sbjct: 62 ---LAEASVMTQLRHSNLVQLLGVIVEE-------KGGLYIVTEYMAKGSLVDYLRSRGR 111 Query: 120 K-FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + + + Y+ N +HRD+ A NVL++ D V K++DFGL + S + Sbjct: 112 SVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ 171 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQ 237 + T ++ W PE L E+ + D+W G ++ E+++ + Sbjct: 172 D------TGKLPVKWT-APEALR-EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV 223 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 + + + P+ P YE+ + + R +L+ + +L Sbjct: 224 VPRVEKGYKMDAPDGCP-PAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHEL 276 >3KRL-A nrPDB Length = 335 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 123/312 (39%), Gaps = 39/312 (12%) Query: 6 DSVECPFCD----EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-----KVALKKVLMENEK 56 D + P+ + + + +G G FG+V +A G+ KVA+K +L Sbjct: 31 DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK-MLKSTAH 89 Query: 57 EGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL 114 + E+KI+ L +HEN+VNL+ C G + ++ ++C DL L Sbjct: 90 ADEKEALMSELKIMSHLGQHENIVNLLGACTHG--------GPVLVITEYCCYGDLLNFL 141 Query: 115 S---------------NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 N + + ++ + G+ ++ +HRD+ A NVL+T Sbjct: 142 RRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN 201 Query: 160 DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIM 219 V K+ DFGLAR N N + + + PE + + Y D+W G ++ Sbjct: 202 GHVAKIGDFGLARDIMNDSNYIVK--GNARLPVKWMAPESIF-DCVYTVQSDVWSYGILL 258 Query: 220 AEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 E+++ G + + + + + + Y + + ++ R + Sbjct: 259 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 318 Query: 279 LKAYVRDPYALD 290 + +++++ D Sbjct: 319 ICSFLQEQAQED 330 >5GRN-A nrPDB Length = 356 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 118/320 (36%), Gaps = 55/320 (17%) Query: 6 DSVECPFCDEVSKYE-------KLAKIGQGTFGEVFKARHRKTGQ-----KVALKKVLME 53 D ++ P+ S++E +G G FG+V + + KVA+K +L Sbjct: 31 DPMQLPYD---SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVK-MLKP 86 Query: 54 NEKEGFPITALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLA 111 + + E+KI+ L H N+VNL+ C G IY++ ++C DL Sbjct: 87 TARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKS--------GPIYIITEYCFYGDLV 138 Query: 112 GLLSNVLVKF-------------------------TLSEIKRVMQMLLNGLYYIHRNKIL 146 L F TL ++ + G+ ++ + Sbjct: 139 NYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCV 198 Query: 147 HRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY 206 HRD+ A NVL+ + ++K+ DFGLAR N T + + + PE + + Y Sbjct: 199 HRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGST--FLPVKWMAPESIF-DNLY 255 Query: 207 GPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL 265 D+W G ++ E+++ G + + + YE+ K Sbjct: 256 TTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKC 315 Query: 266 ELVKGQKRKVKDRLKAYVRD 285 + +KR L V + Sbjct: 316 WNSEPEKRPSFYHLSEIVEN 335 >5U6C-A nrPDB Length = 315 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 107/289 (37%), Gaps = 22/289 (7%) Query: 21 KLAKIGQGTFGEVFKARHRK---TGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 +G+G FG V + ++ T KVA+K + ++N + L E ++ H N Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVF----DFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 V+ L+ +C +S K + L F D + L L L + + M + Sbjct: 100 VMRLLGVCIEMSSQ-GIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDI 158 Query: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 G+ Y+ LHRD+ A N ++ D + +ADFGL++ + R + Sbjct: 159 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKM--PVK 216 Query: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEV 252 + E L +R Y D+W G M E+ TR G + PE Sbjct: 217 WIAIESL-ADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPED 275 Query: 253 WPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPA 301 + + YE+ R L+ ++KLL P Sbjct: 276 CLD-ELYEIMYSCWRTDPLDRPTFSVLRLQ---------LEKLLESLPD 314 >5X5O-A nrPDB Length = 310 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 60/289 (20%), Positives = 109/289 (37%), Gaps = 60/289 (20%) Query: 26 GQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEIC 85 G G+FG V++A+ ++VA+KK+L +E +IL +L H N++ + Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSHRNIIQFYGVI 73 Query: 86 RTKASPYNRCKGSIYLVFDFCE-HDLAGLL-SNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 + +V ++ L + SN + + I + G++Y+H Sbjct: 74 LEPPNYG--------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 125 Query: 144 ---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 K++HRD+K+ NV+I DGVLK+ DFG +R + + V T + PE++ Sbjct: 126 APVKVIHRDLKSRNVVIAADGVLKICDFGASRF------HNHTTHMSLVGTFPWMAPEVI 179 Query: 201 LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYE 260 D + G ++ EM TR +G L+ + Sbjct: 180 QS-LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKN--------------- 223 Query: 261 LYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 E+L + R + L+ + D +R Sbjct: 224 --ERLTIPSSCPRSFAE-------------LLHQCWEADAKKRPSFKQI 257 >1AD5-A nrPDB Length = 438 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 64/283 (22%), Positives = 119/283 (42%), Gaps = 35/283 (12%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR 65 D+ E P + K+G G FGEV+ A + K KVA+K + + L Sbjct: 175 DAWEIP----RESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS---VEAFLA 226 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLL-SNVLVKFTL 123 E +++ L+H+ +V L + K IY++ +F + L L S+ K L Sbjct: 227 EANVMKTLQHDKLVKLHAVV---------TKEPIYIITEFMAKGSLLDFLKSDEGSKQPL 277 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 ++ + G+ +I + +HRD++AAN+L++ V K+ADFGLAR Sbjct: 278 PKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR----------- 326 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALIS 242 + W P + G + D+W G ++ E+ T G + + + Sbjct: 327 -VGAKFPIKWTAPEAINFGS--FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 383 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 + PE P + Y + + + ++R + +++ + D Sbjct: 384 RGYRMPRPENCPE-ELYNIMMRCWKNRPEERPTFEYIQSVLDD 425 >4CRS-A nrPDB Length = 341 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 72/361 (19%), Positives = 137/361 (37%), Gaps = 70/361 (19%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR-EIKI---L 70 + + A + +G FG+V A ++ T + A+K + + + +L E +I + Sbjct: 10 NLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRV 129 ++H +VNL +TK + V ++ DL + + F+ Sbjct: 70 NSVRHPFLVNLFACFQTKE--------HVCFVMEYAAGGDLMMHIHTDV--FSEPRAVFY 119 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 ++ GL Y+H +KI++RD+K N+L+ +G +K+ADFGL + +R + Sbjct: 120 AACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKE----GMGYGDRTSTFC 175 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T + PE+L E Y +D WG G ++ EM G+ E+ I Sbjct: 176 GTPEFLAPEVL-TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN------ 228 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI----- 304 + A+ ++ +LL +P +R+ Sbjct: 229 --------------------------DEVRYPRFLSTEAISIMRRLLRRNPERRLGASEK 262 Query: 305 DSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTN 364 D++D H FF L + M + + PP I + + + T+ Sbjct: 263 DAEDVKKHPFF-------RLIDWSA----LMDKKVKPPF--IPTIRGREDVSNFDDEFTS 309 Query: 365 Q 365 + Sbjct: 310 E 310 >4LQP-A nrPDB Length = 508 Score = 177 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 74/363 (20%), Positives = 119/363 (32%), Gaps = 104/363 (28%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE-KEGFPITALREIKILQLLKH 75 + + IG+G FGEV + + TG+ A+K +L K+ E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQM 132 VV+L + +YL+ +F G L +L++ FT + M Sbjct: 162 PWVVSLYYSFQD--------AQYLYLIMEFLP---GGDLMTMLIRWQLFTEDVTRFYMAE 210 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS-------QPNRY 185 + + IH+ +HR +K N+LI G +KL+DFGL+ F +S Q + Sbjct: 211 CILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEA 270 Query: 186 TNRVV---------------------------------------TLWYRP------PELL 200 TN + + P+ + Sbjct: 271 TNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYI 330 Query: 201 LGE----RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 E + YG D W G IM E P T Q I ++ +P+ Sbjct: 331 APEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTL---QFPDD 387 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI----DSDDALNH 312 + A DLI +LL QR+ +D+ +H Sbjct: 388 IHISY-------------------------EAEDLIRRLLTH-ADQRLGRHGGADEIKSH 421 Query: 313 DFF 315 FF Sbjct: 422 PFF 424 >4YFF-A nrPDB Length = 311 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 16/219 (7%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLL 73 ++S+ E IG G+FG+V+K R R + VA+K+ + RE+ IL L Sbjct: 40 QLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL 97 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQM 132 H V+ + C S + +V + L LL L + Sbjct: 98 NHPCVIQFVGACLNDPSQFA-------IVTQYISGGSLFSLLHEQKRILDLQSKLIIAVD 150 Query: 133 LLNGLYYIHR--NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + G+ Y+H I+HRD+ + N+L+ DG +ADFG +R + T + Sbjct: 151 VAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDE---DNMTKQPG 207 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIM 229 L + PE+ Y D++ + E+ T Sbjct: 208 NLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPF 246 >4R7H-A nrPDB Length = 343 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 61/319 (19%), Positives = 122/319 (38%), Gaps = 46/319 (14%) Query: 6 DSVECPFCD----EVSKYEKLAKIGQGTFGEVFKARHRKTGQ-----KVALKKVLMENEK 56 D + P+ + + + +G G FG+V +A G+ KVA+K +L Sbjct: 35 DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK-MLKSTAH 93 Query: 57 EGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH------- 108 + E+KI+ L +HEN+VNL+ C G + ++ ++C + Sbjct: 94 ADEKEALMSELKIMSHLGQHENIVNLLGACTHG--------GPVLVITEYCTYGDLLNFL 145 Query: 109 ----------------DLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKA 152 D GL L ++ + G+ ++ +HRD+ A Sbjct: 146 RRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAA 205 Query: 153 ANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDL 212 NVL+T V K+ DFGLAR N N + + + PE + + Y D+ Sbjct: 206 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVK--GNARLPVKWMAPESIF-DSVYTVQSDV 262 Query: 213 WGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQ 271 W G ++ E+++ G + + + + + + Y + + ++ Sbjct: 263 WSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPT 322 Query: 272 KRKVKDRLKAYVRDPYALD 290 R ++ +++++ D Sbjct: 323 HRPTFQQITSFLQEQAQED 341 >3G0E-A nrPDB Length = 336 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 111/336 (33%), Gaps = 73/336 (21%) Query: 6 DSVECPFCD----EVSKYEKLAKIGQGTFGEVFKAR-----HRKTGQKVALKKVLMENEK 56 D + P+ ++ +G G FG+V +A VA+K +L + Sbjct: 31 DPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVK-MLKPSAH 89 Query: 57 EGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL 114 + E+K+L L H N+VNL+ C G ++ ++C DL L Sbjct: 90 LTEREALMSELKVLSYLGNHMNIVNLLGACT--------IGGPTLVITEYCCYGDLLNFL 141 Query: 115 SNVLVKFTLSEIK-----------------RVMQMLLNGLYYIHRNKILHRDMKAANVLI 157 F S+ + G+ ++ +HRD+ A N+L+ Sbjct: 142 RRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILL 201 Query: 158 TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGC 217 T + K+ DFGLAR N N + + + PE + Y D+W G Sbjct: 202 THGRITKICDFGLARDIKNDSNYVVK--GNARLPVKWMAPESIFN-CVYTFESDVWSYGI 258 Query: 218 IMAEMWT-RSPIMQG-NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKV 275 + E+++ S G + +I + ++PE P Sbjct: 259 FLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPA-------------------- 298 Query: 276 KDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 D++ DP +R + Sbjct: 299 -----------EMYDIMKTCWDADPLKRPTFKQIVQ 323 >5AMN-A nrPDB Length = 299 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 63/294 (21%), Positives = 113/294 (38%), Gaps = 38/294 (12%) Query: 21 KLAKIGQGTFGEVFKARHRKTG-----QKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +G+G FG+V KA VA+K +L EN L E +L+ + H Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVK-MLKENASPSELRDLLSEFNVLKQVNH 85 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV---------KFTLSE 125 +V+ L C G + L+ ++ + L G L T+ + Sbjct: 86 PHVIKLYGACSQD--------GPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGD 137 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 + + G+ Y+ K++HRD+ A N+L+ +K++DFGL+R ++S R Sbjct: 138 LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV-YEEDSYVKRS 196 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQL 244 R+ W E L + Y D+W G ++ E+ T G + L+ Sbjct: 197 QGRIPVKW-MAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTG 254 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 P+ E L+ ++ D+ + + DL +K++V Sbjct: 255 HRMERPDNCSE-------EMYRLMLQCWKQEPDKRPVFAD--ISKDL-EKMMVK 298 >3DLS-A nrPDB Length = 335 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 67/355 (18%), Positives = 124/355 (34%), Gaps = 64/355 (18%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALR------EIKILQ 71 KY ++ +G G FG V+ A ++ ++V +K + E E I + EI IL Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL-AGLLSNVLVKFTLSEIKRVM 130 ++H N++ +++I + G LV + L + + + Sbjct: 85 RVEHANIIKVLDIFENQ--------GFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIF 136 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 + L++ + Y+ I+HRD+K N++I D +KL DFG A K + Sbjct: 137 RQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGK-----LFYTFCG 191 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 T+ Y PE+L+G GP +++W G + + E + A+ Sbjct: 192 TIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAI---------- 241 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 Y+ + L+ LL P +R + + Sbjct: 242 ----------------------------HPPYLVSKELMSLVSGLLQPVPERRTTLEKLV 273 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQ 365 + P +L +F P S + + N+S + Q Sbjct: 274 TDPWVTQ---PVNLADY---TWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQ 322 >2RIO-A nrPDB Length = 434 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 78/377 (20%), Positives = 145/377 (38%), Gaps = 72/377 (19%) Query: 23 AKIGQGTFGEV-FKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLLKHENVVN 80 +G G+ G V F+ + G+ VA+K++L++ F AL EIK+L + H NV+ Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRMLID-----FCDIALMEIKLLTESDDHPNVIR 73 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL------SNVLVKFTLSEIKRVMQMLL 134 C + +Y+ + C +L L+ L +++ + Sbjct: 74 YY--CSETTDRF------LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIA 125 Query: 135 NGLYYIHRNKILHRDMKAANVLIT-------------RDGVLKLADFGLARAFSLAKNSQ 181 +G+ ++H KI+HRD+K N+L++ + + ++DFGL + ++S Sbjct: 126 SGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSF 185 Query: 182 PNRYTNRVVTLWYRPPEL------LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQ 235 N T +R PEL L +R ID++ GC+ + ++ G+ Sbjct: 186 RTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYS 245 Query: 236 HQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKL 295 + +I + ++D + L+ A DLI ++ Sbjct: 246 RESNIIRGIF---------SLDEMKCLHDRSLIA-----------------EATDLISQM 279 Query: 296 LVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTN 355 + DP +R + L H FW P L+ +L E PP + S Sbjct: 280 IDHDPLKRPTAMKVLRHPLFW--PKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSD- 336 Query: 356 QSRNPATTNQTEFERVF 372 P+ +F++ F Sbjct: 337 -FVIPSGDWTVKFDKTF 352 >6CTH-A nrPDB Length = 309 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 112/257 (43%), Gaps = 25/257 (9%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 S + K+G+G FG V++ R + +A+KKV K+G A E+KI+ Sbjct: 9 ELAKVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKV-SRASKQGIKEYA-SEVKII 66 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRV 129 L+H+N+V LI C +G + LV++F L + T R+ Sbjct: 67 SRLRHKNLVKLIGWCHE--------RGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRI 118 Query: 130 MQMLLNGLYYIHRNK---ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ L + L Y+H +LHRD+K +N+++ KL DFGLAR AK + Sbjct: 119 VKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLL- 177 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 T+ Y PE L + D++ G + E+ + ++ E+ + L+ Sbjct: 178 --AGTVGYMAPECLSSGKA-SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLV---- 230 Query: 247 SITPEVWPNVDNYELYE 263 P VW + N + + Sbjct: 231 ---PWVWESYGNERILD 244 >6FER-A nrPDB Length = 309 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 112/316 (35%), Gaps = 60/316 (18%) Query: 20 EKLAKIGQGTFGEVFKAR--------------HRKTGQ--KVALKKVLMENEKEGFPITA 63 K+G+G FGEV Q VA+K +L + + Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVK-MLRADANKNARNDF 70 Query: 64 LREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV----- 117 L+EIKI+ LK N+++L+ +C T + ++ ++ E DL LS Sbjct: 71 LKEIKIMSRLKDPNIIHLLAVCITD--------DPLCMITEYMENGDLNQFLSRHEPPNS 122 Query: 118 ----LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARA 173 + + + +K + + +G+ Y+ +HRD+ N L+ ++ +K+ADFG++R Sbjct: 123 SSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRN 182 Query: 174 FSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNT 233 + + W +LLG+ + D+W G + E +T Sbjct: 183 LYSGDYYRIQGRAV-LPIRWMSWESILLGK--FTTASDVWAFGVTLWETFT----FCQEQ 235 Query: 234 EQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLID 293 QL+ +V N + + + Q D + L+ Sbjct: 236 PYSQLS---------DEQVIENTGEFFRDQGRQTYLPQPAICPDSVYK---------LML 277 Query: 294 KLLVLDPAQRIDSDDA 309 D R + Sbjct: 278 SCWRRDTKNRPSFQEI 293 >3MY0-A nrPDB Length = 305 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 124/301 (41%), Gaps = 37/301 (12%) Query: 21 KLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 + +G+G +GEV++ G+ VA+K +E+ F T EI LL+H+N++ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRET---EIYNTVLLRHDNILG 66 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLNGLY 138 I T + ++L+ + EH G L + L + TL R+ GL Sbjct: 67 FIASDMTSRN----SSTQLWLITHYHEH---GSLYDFLQRQTLEPHLALRLAVSAACGLA 119 Query: 139 YIH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVV 190 ++H + I HRD K+ NVL+ + +AD GLA S + RV Sbjct: 120 HLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVG 179 Query: 191 TLWYRPPELLLGERDYG-----PPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 T Y PE+L + D+W G ++ E+ R+ + I + Sbjct: 180 TKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRT----------IVNGIVEDY 229 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 +V PN ++E +K+ V Q + +RL A ++ + +P+ R+ Sbjct: 230 RPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLT 289 Query: 306 S 306 + Sbjct: 290 A 290 >4IDT-A nrPDB Length = 356 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 110/311 (35%), Gaps = 47/311 (15%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 + ++ V+ + +EV ++G+G+FGEV + ++TG + A+KKV +E Sbjct: 58 LTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLE------- 110 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 + E+ L +V L R + + + E G L Sbjct: 111 VFRAEELMACAGLTSPRIVPLYGAVREGP--------WVNIFMELLEGGSLGQLVKEQGC 162 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKN 179 + L GL Y+H +ILH D+KA NVL++ DG L DFG A Sbjct: 163 LPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGL 222 Query: 180 SQPNRYTNRV-VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 + + + T + PE++LG R +D+W + C+M M Sbjct: 223 GKDLLTGDYIPGTETHMAPEVVLG-RSCDAKVDVWSSCCMMLHMLNGC------------ 269 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 W L K+ R++ I + L Sbjct: 270 ------------HPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQA-----IQEGLRK 312 Query: 299 DPAQRIDSDDA 309 +P R+ + + Sbjct: 313 EPIHRVSAAEL 323 >4TPT-A nrPDB Length = 303 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 108/285 (37%), Gaps = 29/285 (10%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 +G+G FG+ K H+ TG+ + +K+++ E T L E+K+++ L H NV+ I Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIR--CDEETQKTFLTEVKVMRSLDHPNVLKFI 63 Query: 83 EICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142 + + L+ ++ E + F + R + + +G+ Y+H Sbjct: 64 GVLYKDK--------KLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHS 115 Query: 143 NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP----------------NRYT 186 I+HRD+ + N LI D + +ADFGL+R + P + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 V ++ PE+L G + Y +D++ G ++ E+ + L + Sbjct: 176 TVVGNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEII-GQVYADPDCLPRTLDFGLNVK- 232 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 + P + + + + + AL L Sbjct: 233 LFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSL 277 >4LRM-A nrPDB Length = 334 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 111/297 (37%), Gaps = 25/297 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKV----ALKKVLMENEKEGFPITALREIKILQL 72 ++++K+ +G G FG V+K G+KV A+K++ E L E ++ Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMAS 77 Query: 73 LKHE---NVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKR 128 + + +V L+ IC T + L+ L + + Sbjct: 78 VDNPGNPHVCRLLGICLTST---------VQLITQLMPFGCLLDYVREHKDNIGSQYLLN 128 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 + G+ Y+ +++HRD+ A NVL+ +K+ DFGLA+ + + Sbjct: 129 WCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGK 187 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGS 247 V W +L R Y D+W G + E+ T S G +++ + Sbjct: 188 VPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL 245 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 P + +D Y + K ++ R L A D + LV+ +R+ Sbjct: 246 PQPPIC-TIDVYMIMVKCWMIDADSRPKFRELIIEF-SKMARD-PQRYLVIQGDERM 299 >3UIU-A nrPDB Length = 306 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 71/320 (22%), Positives = 123/320 (38%), Gaps = 77/320 (24%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 ++++ IG G FG+VFKA+HR G+ +++V NEK A RE+K L L H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVN 66 Query: 78 VVNLIEICRTKASPYNRCKGSI---------------------YLVFDFCEHDLAGLLSN 116 +V+ S+ ++ +FC+ G L Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCD---KGTLEQ 123 Query: 117 VLVKFTLSEIKRVMQ-----MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171 + K ++ +V+ + G+ YIH K++HRD+K +N+ + +K+ DFGL Sbjct: 124 WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLV 183 Query: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 + + T TL Y PE + +DYG +DL+ G I+AE+ Sbjct: 184 TSLKND-----GKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL-------- 229 Query: 232 NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 + + ++D + + + D L Sbjct: 230 ----------------------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKTL 261 Query: 292 IDKLLVLDPAQRIDSDDALN 311 + KLL P R ++ + L Sbjct: 262 LQKLLSKKPEDRPNTSEILR 281 >3I81-A nrPDB Length = 315 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 120/297 (40%), Gaps = 34/297 (11%) Query: 7 SVECPFCDEV--SKYEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLMENEKEGF 59 V P EV K ++GQG+FG V++ + + +VA+K V E Sbjct: 6 DVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRE 64 Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVL 118 I L E +++ +VV L+ + ++ + DL L ++ Sbjct: 65 RIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL--------VIMELMTRGDLKSYLRSLR 116 Query: 119 VKF---------TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG 169 + +LS++ ++ + +G+ Y++ NK +HRD+ A N ++ D +K+ DFG Sbjct: 117 PEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFG 176 Query: 170 LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTR-SPI 228 + R + ++ + + PE L + + D+W G ++ E+ T Sbjct: 177 MTRDIYETDYYRKG--GKGLLPVRWMSPESL-KDGVFTTYSDVWSFGVVLWEIATLAEQP 233 Query: 229 MQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 QG + + L + + P+ P++ L+E + + K++ + Sbjct: 234 YQGLSNEQVLRFVMEGGLLDKPDNCPDM----LFELMRMCWQYNPKMRPSFLEIISS 286 >1PY5-A nrPDB Length = 326 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 136/303 (44%), Gaps = 41/303 (13%) Query: 21 KLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ--LLKHENV 78 IG+G FGEV++ + R G++VA+K E+ F RE +I Q +L+HEN+ Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWF-----REAEIYQTVMLRHENI 85 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLNG 136 + I + N ++LV D+ EH G L + L ++T++ + ++ +G Sbjct: 86 LGFIAA----DNKDNGTWTQLWLVSDYHEH---GSLFDYLNRYTVTVEGMIKLALSTASG 138 Query: 137 LYYIH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 L ++H + I HRD+K+ N+L+ ++G +AD GLA A ++ +R Sbjct: 139 LAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHR 198 Query: 189 VVTLWYRPPELL-----LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 V T Y PE+L + + D++ G + E+ R I G E +QL Sbjct: 199 VGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQL----- 252 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 ++ P+ + E K+ + + + +R ++ ++ + + A R Sbjct: 253 ----PYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAAR 308 Query: 304 IDS 306 + + Sbjct: 309 LTA 311 >3QUP-A nrPDB Length = 323 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 101/301 (33%), Gaps = 52/301 (17%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTG---QKVALKKVLMENEKEGFPITALREIKILQLLK 74 ++ +G+G FG V +A+ ++ KVA+K + + LRE ++ Sbjct: 24 QFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFD 83 Query: 75 HENVVNLIEICRTKASPYNRCKGSI---YLVFDFCEHD------LAGLLSNVLVKFTLSE 125 H +V L+ + S +R KG + ++ F +H LA + L Sbjct: 84 HPHVAKLVGV-----SLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQT 138 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY 185 + R M + G+ Y+ +HRD+ A N ++ D + +ADFGL+R + Sbjct: 139 LVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQG-C 197 Query: 186 TNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQL 244 +++ W L + Y D+W G M E+ T G + Sbjct: 198 ASKLPVKWLALESL--ADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGG 255 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 P DL+ + DP QR Sbjct: 256 NRLKQPPEC-------------------------------MEEVYDLMYQCWSADPKQRP 284 Query: 305 D 305 Sbjct: 285 S 285 >3MDY-A nrPDB Length = 337 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 135/302 (44%), Gaps = 37/302 (12%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 + + +IG+G +GEV+ + R G+KVA+K E F T EI L++HEN++ Sbjct: 40 QMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRET---EIYQTVLMRHENIL 94 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLS--EIKRVMQMLLNGL 137 I + +YL+ D+ E+ G L + L TL + ++ ++GL Sbjct: 95 GFIAADIKGTGSWT----QLYLITDYHEN---GSLYDYLKSTTLDAKSMLKLAYSSVSGL 147 Query: 138 YYIH--------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 ++H + I HRD+K+ N+L+ ++G +AD GLA F N RV Sbjct: 148 CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRV 207 Query: 190 VTLWYRPPELLLG--ERDYGPP---IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 T Y PPE+L R++ D++ G I+ E+ R + G E++QL Sbjct: 208 GTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRC-VSGGIVEEYQL------ 260 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 ++ P+ +YE ++ +K + +R + L+ + +PA R+ Sbjct: 261 ---PYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRL 317 Query: 305 DS 306 + Sbjct: 318 TA 319 >3M42-A nrPDB Length = 299 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 113/311 (36%), Gaps = 73/311 (23%) Query: 16 VSKYEKL-AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL-QLL 73 + Y+ +G G G+V + +++T +K ALK + A RE+++ + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRV 129 + ++V ++++ + + +V + + L S + + FT E + Sbjct: 69 QCPHIVRIVDVYEN----LYAGRKCLLIVMECLDG--GELFSRIQDRGDQAFTEREASEI 122 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYT 186 M+ + + Y+H I HRD+K N+L T + +LKL DFG A+ + K Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEK-------- 174 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 Y D+W G IM + P N Sbjct: 175 -------------------YDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------- 204 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P + + E + +V + +K LI LL +P QR+ Sbjct: 205 ----AISPGMKTRIRMGQYEFPNPEWSEVSEEVKM---------LIRNLLKTEPTQRMTI 251 Query: 307 DDALNHDFFWS 317 + +NH + Sbjct: 252 TEFMNHPWIMQ 262 >3ZBF-A nrPDB Length = 322 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 55/260 (21%), Positives = 101/260 (38%), Gaps = 31/260 (11%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRK-----TGQ-KVALKKVLMENEKEGFPITALREIK 68 K +G G FGEV++ +G+ KVA+K + + + I L+E Sbjct: 31 PREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTL-KKGSTDQEKIEFLKEAH 89 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSN------VLVKF 121 ++ H N++ + +C Y++ + E DL L Sbjct: 90 LMSKFNHPNILKQLGVCLLNEPQ--------YIILELMEGGDLLTYLRKARMATFYGPLL 141 Query: 122 TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI-----TRDGVLKLADFGLARAFSL 176 TL ++ + + G Y+ R +HRD+ A N L+ T ++K+ DFGLAR Sbjct: 142 TLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY- 200 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQ 235 KN + ++ + + PE L+ + + D+W G ++ E+ T ++ Sbjct: 201 -KNDYYRKRGEGLLPVRWMAPESLM-DGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNL 258 Query: 236 HQLALISQLCGSITPEVWPN 255 L + P P+ Sbjct: 259 DVLNYVQTGGRLEPPRNCPD 278 >4F9B-A nrPDB Length = 361 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 90/369 (24%), Positives = 147/369 (39%), Gaps = 71/369 (19%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARH---RKTGQKVALKKVLMENEKE 57 + K Y++V P V ++ KIG+GTF V+ A +K+ALK ++ Sbjct: 9 IEKLYEAV--PQLSNV--FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLI----PT 60 Query: 58 GFPITALREIKILQLLKH-ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSN 116 PI E++ L + +NV+ + R + + + EH + Sbjct: 61 SHPIRIAAELQCLTVAGGQDNVMGVKYCFR--------KNDHVVIAMPYLEH---ESFLD 109 Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLK-LADFGLARAFS 175 +L + E++ M L L IH+ I+HRD+K +N L R L DFGLA+ Sbjct: 110 ILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTH 169 Query: 176 LAK------------------------NSQPNRYTNRVVTLWYRPPELLLGERDYGPPID 211 K S+ + R T +R PE+L + ID Sbjct: 170 DTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAID 229 Query: 212 LWGAGCIMAEMWTR-SPIMQGNTEQHQLALISQLCGS--------------ITPEVWPNV 256 +W AG I + + P + + + LA I + GS + + P Sbjct: 230 MWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQ 289 Query: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRD--------PYALDLIDKLLVLDPAQRIDSDD 308 D +L E+L + K+ ++ + + A DL+DKLL L+PA RI +++ Sbjct: 290 DLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEE 349 Query: 309 ALNHDFFWS 317 AL H FF Sbjct: 350 ALLHPFFKD 358 >5TOS-A nrPDB Length = 395 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 112/307 (36%), Gaps = 42/307 (13%) Query: 18 KYEKLAKIGQGTFGEVFKA---------RHRKTGQKVALKKVLMENEKEGFPITALREIK 68 + + IG+G FG VFK TG +A+KK+ E + L EI Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEIN 123 Query: 69 ILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSN---VLVKFTLS 124 L L H N+V LI C LV++F + L L Sbjct: 124 YLGQLSHPNLVKLIGYCLEDEHRL--------LVYEFMQKGSLENHLFRRGAYFKPLPWF 175 Query: 125 EIKRVMQMLLNGLYYIHRN--KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP 182 V GL ++H + K+++RD+KA+N+L+ D KL+DFGLAR + S Sbjct: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + T + T Y PE + D++ G ++ E+ + + N + L+ Sbjct: 236 S--TRVMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV- 291 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 W + L +V + +A A+ + L +P Sbjct: 292 ---------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV----QCLSFEPKS 338 Query: 303 RIDSDDA 309 R D Sbjct: 339 RPTMDQV 345 >5FM2-A nrPDB Length = 355 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 63/308 (20%), Positives = 113/308 (36%), Gaps = 52/308 (16%) Query: 21 KLAKIGQGTFGEVFKARHRKTG-----QKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +G+G FG+V KA VA+K +L EN L E +L+ + H Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVK-MLKENASPSELRDLLSEFNVLKQVNH 126 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV--------------- 119 +V+ L C G + L+ ++ + L G L Sbjct: 127 PHVIKLYGACSQD--------GPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS 178 Query: 120 --------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA 171 T+ ++ + G+ Y+ K++HRD+ A N+L+ +K++DFGL+ Sbjct: 179 SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS 238 Query: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQ 230 R ++S R R+ W E L + Y D+W G ++ E+ T Sbjct: 239 RDV-YEEDSYVKRSQGRIPVKW-MAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYP 295 Query: 231 GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 G + L+ P+ E L+ ++ D+ + + D Sbjct: 296 GIPPERLFNLLKTGHRMERPDNCSE-------EMYRLMLQCWKQEPDKRPVFAD--ISKD 346 Query: 291 LIDKLLVL 298 L +K++V Sbjct: 347 L-EKMMVK 353 >4G3E-A nrPDB Length = 352 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 61/311 (19%), Positives = 111/311 (35%), Gaps = 47/311 (15%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP 60 + ++ V+ + +EV ++G+G+FGEV + + ++TG + A+KKV +E Sbjct: 58 LTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLE------- 110 Query: 61 ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 + + E+ L +V L R + + + E G L + Sbjct: 111 VFRVEELVACAGLSSPRIVPLYGAVREGP--------WVNIFMELLEGGSLGQLIKQMGC 162 Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-LKLADFGLARAFSLAKN 179 + L GL Y+H +ILH D+KA NVL++ DG L DFG A Sbjct: 163 LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGL 222 Query: 180 SQPNRYTNRV-VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 + + + T + PE+++G + +D+W + C+M M Sbjct: 223 GKSLLTGDYIPGTETHMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNGCHP---------- 271 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 + + +K R P I + L Sbjct: 272 -------------------WTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRK 312 Query: 299 DPAQRIDSDDA 309 +P R + + Sbjct: 313 EPVHRASAMEL 323 >2PMN-X nrPDB Length = 348 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 127/341 (37%), Gaps = 39/341 (11%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++ Y + + QG F ++ K + ALKK ++ T KI K+ Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 76 ENVVNLIEICRTKASPYNRC-------KGSIYLVFDFCEHD--------LAGLLSNVLVK 120 ++ N ++I + Y +Y+++++ E+D L N Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 121 FTLSEIKRVMQMLLNGLYYIH-RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKN 179 + IK +++ +LN YIH I HRD+K +N+L+ ++G +KL+DFG + K Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKK- 206 Query: 180 SQPNRYTNRVVTLWYRPPELLLGERDY-GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQL 238 T + PPE E Y G +D+W G + M+ +L Sbjct: 207 -----IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVEL 261 Query: 239 ALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVL 298 + N E K +D + L Sbjct: 262 FNNIR------------TKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRK 309 Query: 299 DPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYL 339 +PA+RI S+DAL H++ +D DL+ S L + L Sbjct: 310 NPAERITSEDALKHEWL-ADTNIEDLREF-SKELYKKRKKL 348 >3QD2-B nrPDB Length = 332 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 117/339 (34%), Gaps = 77/339 (22%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 ++ +E + +G+G FG VF+A+++ A+K++ + N +E +RE+K L L+H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN-RELAREKVMREVKALAKLEH 63 Query: 76 ENVVNLIEICRTKAS--------------------------------------------- 90 +V Sbjct: 64 PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNT 123 Query: 91 ----PYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE---IKRVMQMLLNGLYYIHRN 143 + K +Y+ C + N E + + + ++H Sbjct: 124 VGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSK 183 Query: 144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQP--------NRYTNRVVTLWYR 195 ++HRD+K +N+ T D V+K+ DFGL A + Q +T +V T Y Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 PE + G +Y +D++ G I+ E+ +T+ ++ +I+ + Sbjct: 244 SPEQIHGN-NYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNL-------- 289 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDK 294 + L + + + P A D+I+ Sbjct: 290 --KFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIEN 326 >3AOX-A nrPDB Length = 344 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 56/290 (19%), Positives = 114/290 (39%), Gaps = 31/290 (10%) Query: 20 EKLAKIGQGTFGEVFKAR-----HRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 + +G G FGEV++ + + + +VA+K + E E + L E I+ Sbjct: 50 TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELDFLMEALIISKFN 108 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVK------FTLSEIK 127 H+N+V I + + ++ + DL L + + ++ Sbjct: 109 HQNIVRCIGVSLQSLPRF--------ILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLL 160 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG---VLKLADFGLARAFSLAKNSQPNR 184 V + + G Y+ N +HRD+ A N L+T G V K+ DFG+AR A + Sbjct: 161 HVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGG 220 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQ 243 ++ + + PPE + E + D W G ++ E+++ + Q L ++ Sbjct: 221 CA--MLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS 277 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRK---VKDRLKAYVRDPYALD 290 P+ P + + + + + +R++ +DP ++ Sbjct: 278 GGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVIN 327 >4X7Q-B nrPDB Length = 312 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 56/324 (17%), Positives = 104/324 (32%), Gaps = 67/324 (20%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN----EKEGFPITALREIKILQLL 73 +Y +G+G FG VF +VA+K + +T E+ +L + Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 74 K----HENVVNLIEICRTKASPYNRCKGSIYLVFD--FCEHDLAGLLSNVLVKFTLSEIK 127 H V+ L++ T+ LV + DL ++ + Sbjct: 92 GAGGGHPGVIRLLDWFETQEG--------FMLVLERPLPAQDLFDYITEK-GPLGEGPSR 142 Query: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ + + H ++HRD+K N+LI R G KL DFG YT Sbjct: 143 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEP------YT 196 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + T Y PPE + + + P +W G ++ +M + + E + Sbjct: 197 DFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILE--------- 247 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 + P LI + L P+ R Sbjct: 248 -----------------------------AELHFPAHVSPDCCALIRRCLAPKPSSRPSL 278 Query: 307 DDALNHDFFWSDPMPSDLKGMLST 330 ++ L + + P++ + + Sbjct: 279 EEILLDPWMQT---PAEDVPLNPS 299 >5WNL-A nrPDB Length = 342 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 61/353 (17%), Positives = 134/353 (37%), Gaps = 55/353 (15%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 + ++ K+G G FG+V+K RH +A+K + + + L E K +++ K Sbjct: 18 DAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAK 77 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQML 133 ++ + IC+ + LV ++ E L LL++ R++ Sbjct: 78 FRYILPVYGICQE----------PVGLVMEYMETGSLEKLLAS--EPLPWDLRFRIVHET 125 Query: 134 LNGLYYIH--RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 G+ ++H +LH ++K AN+L+ +K++DFGLA+ ++ +S T Sbjct: 126 AVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMS-HSHDLSMDGLFGT 184 Query: 192 LWYRPPELLLGE-RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITP 250 + Y PPE + + R + D++ ++ + T+ E++ L ++ ++ P Sbjct: 185 IAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF--ADEKNILHIMMKVVKGHRP 242 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDAL 310 E+ P + + + R + L+ + DP R + Sbjct: 243 ELPP------------ICRPRPRACASLIG----------LMQRCWHADPQVRPTFQEI- 279 Query: 311 NHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATT 363 DL + + + +S +++R ++ Sbjct: 280 -------TSETEDLCEKPDEEVKDLAHEPGEKS------SLESKSEARPESSR 319 >4NEU-A nrPDB Length = 333 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 106/274 (38%), Gaps = 19/274 (6%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 S + + A++ G FG+V HR G + +K V L E K++ L+H Sbjct: 24 SDFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHS 82 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 VV L+ + +G LV ++ E + + LS R++ ++ G Sbjct: 83 RVVKLLGVIIE--------EGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 134 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLA--RAFSLAKNSQPNRYTNR------ 188 + Y+H ++H+D+K N+L+ D +K+AD GLA + +S N + N Sbjct: 135 MCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKK 194 Query: 189 -VVTLWYRPPELLLG-ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 TL+Y PE L D++ ++ ++ + + QL + + Sbjct: 195 NGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGN 254 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLK 280 + E+ ++L + + Sbjct: 255 RPDVDDITEYCPREIISLMKLCWEANPEARPTFP 288 >5TUR-A nrPDB Length = 404 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 105/320 (32%), Gaps = 62/320 (19%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI----TALREIKILQL 72 S+Y+ +G G FG V+ VA+K V + + + E+ +L+ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 73 LKHEN--VVNLIEICRTKASPYNRCKGSIYLVFDFCE--HDLAGLLSNVLVKFTLSEIKR 128 + V+ L++ S L+ + E DL ++ + Sbjct: 187 VSSGFSGVIRLLDWFERP--------DSFVLILERPEPVQDLFDFITE-RGALQEELARS 237 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTN 187 +L + + H +LHRD+K N+LI G LKL DFG + YT+ Sbjct: 238 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTD 291 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T Y PPE + R +G +W G ++ +M + + E + + + Sbjct: 292 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---- 347 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 LI L L P+ R + Sbjct: 348 ----------------------------------QRVSSECQHLIRWCLALRPSDRPTFE 373 Query: 308 DALNHDFFWSDPMPSDLKGM 327 + NH + +P + + Sbjct: 374 EIQNHPWMQDVLLPQETAEI 393 >3BGP-A nrPDB Length = 333 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 105/320 (32%), Gaps = 62/320 (19%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI----TALREIKILQL 72 S+Y+ +G G FG V+ VA+K V + + + E+ +L+ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 73 LKHEN--VVNLIEICRTKASPYNRCKGSIYLVFDFCE--HDLAGLLSNVLVKFTLSEIKR 128 + V+ L++ S L+ + E DL ++ + Sbjct: 116 VSSGFSGVIRLLDWFERP--------DSFVLILERPEPVQDLFDFITE-RGALQEELARS 166 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTN 187 +L + + H +LHRD+K N+LI G LKL DFG + YT+ Sbjct: 167 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTD 220 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T Y PPE + R +G +W G ++ +M + + E + + + Sbjct: 221 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---- 276 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 LI L L P+ R + Sbjct: 277 ----------------------------------QRVSSECQHLIRWCLALRPSDRPTFE 302 Query: 308 DALNHDFFWSDPMPSDLKGM 327 + NH + +P + + Sbjct: 303 EIQNHPWMQDVLLPQETAEI 322 >4FL3-A nrPDB Length = 635 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 53/236 (22%), Positives = 93/236 (39%), Gaps = 14/236 (5%) Query: 23 AKIGQGTFGEVFKARHR--KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 ++G G FG V K ++ K + VA+K + E L E ++Q L + +V Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 +I IC + S LV + E I ++ + G+ Y+ Sbjct: 435 MIGICEAE---------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 + +HRD+ A NVL+ K++DFGL++A +N + + WY PE + Sbjct: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI 544 Query: 201 LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 + D+W G +M E ++ +G A++ + P P Sbjct: 545 -NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 >4RC3-A nrPDB Length = 289 Score = 163 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 105/320 (32%), Gaps = 62/320 (19%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI----TALREIKILQL 72 S+Y+ +G G FG V+ VA+K V + + + E+ +L+ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 73 LKHEN--VVNLIEICRTKASPYNRCKGSIYLVFDFCE--HDLAGLLSNVLVKFTLSEIKR 128 + V+ L++ S L+ + E DL ++ + Sbjct: 72 VSSGFSGVIRLLDWFERP--------DSFVLILERPEPVQDLFDFITE-RGALQEELARS 122 Query: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTN 187 +L + + H +LHRD+K N+LI G LKL DFG + YT+ Sbjct: 123 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTD 176 Query: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T Y PPE + R +G +W G ++ +M + + E + + + Sbjct: 177 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---- 232 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 LI L L P+ R + Sbjct: 233 ----------------------------------QRVSSECQHLIRWCLALRPSDRPTFE 258 Query: 308 DALNHDFFWSDPMPSDLKGM 327 + NH + +P + + Sbjct: 259 EIQNHPWMQDVLLPQETAEI 278 >2BUJ-A nrPDB Length = 317 Score = 163 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 105/303 (34%), Gaps = 46/303 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y + K+G+G F V G ALK++L ++ A RE + +L H N+ Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREADMHRLFNHPNI 88 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA----GLLSNVLVKFTLSEIKRVMQMLL 134 + L+ C + + +L+ F + L + T +I ++ + Sbjct: 89 LRLVAYCLRERGAKHEA----WLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGIC 144 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT-----NRV 189 GL IH HRD+K N+L+ +G L D G + T + Sbjct: 145 RGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 190 VTLWYRPPELLLGERDY--GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247 T+ YR PEL + D+W GC++ M Sbjct: 205 CTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDM---------------- 248 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 V+ D+ L + +L Q + L L++ ++ +DP QR Sbjct: 249 ----VFQKGDSVALAVQNQLSIPQSPRHSSALWQ---------LLNSMMTVDPHQRPHIP 295 Query: 308 DAL 310 L Sbjct: 296 LLL 298 >6J5U-C nrPDB Length = 426 Score = 163 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 79/349 (22%), Positives = 134/349 (38%), Gaps = 56/349 (16%) Query: 25 IGQGTFGEVFKARHRKT---------GQKVALKKVLMENEKEGFPITALREIKILQLLKH 75 +G+G FG VFK +T G VA+K++ E + L E+ L L H Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQ--GHKEWLTEVNYLGQLSH 149 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-----FTLSEIKRVM 130 N+V L+ C + LV++F G L N L + T + +V Sbjct: 150 PNLVLLVGYCAEGENRL--------LVYEFMP---KGSLENHLFRRGAQPLTWAIRMKVA 198 Query: 131 QMLLNGLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 GL ++H K +++RD KAAN+L+ D KL+DFGLA+A N+ + T Sbjct: 199 VGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVS--TKV 256 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 + T Y PE + R D++ G ++ E+ + M + ++ +L+ Sbjct: 257 IGTHGYAAPEYVATGRL-TAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV------- 308 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 D +L+ ++ G + K A +L + L D R + Sbjct: 309 DWATPYLGDKRKLFRIMDTKLGGQYPQKGAF-------TAANLALQCLNPDAKLRPKMSE 361 Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQS 357 L L+ + + + PR S + Q+S + Sbjct: 362 VL--------VTLEQLESVAKPG--TKHTQMESPRFHHSSVMQKSPVRY 400 >5LPZ-A nrPDB Length = 332 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 118/300 (39%), Gaps = 36/300 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + + IG G FG+V+KA + G VA+KK++ + + + E++ + +KH N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNL 75 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV---KFTLSEIKRVMQMLL 134 V L+ C+ LV++F + L +L + K S +++ Sbjct: 76 VPLLGYCKVGDERL--------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSA 127 Query: 135 NGLYYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 GL ++H N I+HRDMK++NVL+ + +++DFG+AR S + T Sbjct: 128 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLS--VSTLAGT 185 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PPE R D++ G ++ E+ T + L G + Sbjct: 186 PGYVPPEYYQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGD-----NNLVGWVKQH 239 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + + E ++ + ++ LK V L +R + Sbjct: 240 AKLRISDVFDPELMKEDPALEIELLQHLKVAVA----------CLDDRAWRRPTMVQVMA 289 >5LPV-A nrPDB Length = 296 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 118/300 (39%), Gaps = 36/300 (12%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 + + IG G FG+V+KA + G VA+KK++ + + + E++ + +KH N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNL 75 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV---KFTLSEIKRVMQMLL 134 V L+ C+ LV++F + L +L + K S +++ Sbjct: 76 VPLLGYCKVGDERL--------LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSA 127 Query: 135 NGLYYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 GL ++H N I+HRDMK++NVL+ + +++DFG+AR S + T Sbjct: 128 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLS--VSTLAGT 185 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 Y PPE R D++ G ++ E+ T + L G + Sbjct: 186 PGYVPPEYYQSFR-CSTKGDVYSYGVVLLELLTGKRPTDSPDFGD-----NNLVGWVKQH 239 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 + + E ++ + ++ LK V L +R + Sbjct: 240 AKLRISDVFDPELMKEDPALEIELLQHLKVAVA----------CLDDRAWRRPTMVQVMA 289 >5C26-A nrPDB Length = 299 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 50/236 (21%), Positives = 91/236 (38%), Gaps = 14/236 (5%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENE--KEGFPITALREIKILQLLKHENVVN 80 ++G G FG V K ++ + +++NE L E ++Q L + +V Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 +I IC + S LV + E I ++ + G+ Y+ Sbjct: 93 MIGICEAE---------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 143 Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200 + +HRD+ A NVL+ K++DFGL++A +N + + WY PE + Sbjct: 144 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI 202 Query: 201 LGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 + D+W G +M E ++ +G A++ + P P Sbjct: 203 -NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 257 >5TE0-A nrPDB Length = 347 Score = 160 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 75/356 (21%), Positives = 134/356 (37%), Gaps = 55/356 (15%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVNL 81 + +G F VF R G K ALK++ + N E REI+I++ L H+N+V Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNN--EHDLQVCKREIQIMRDLSGHKNIVGY 81 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGLYY 139 I+ + + + + ++ DFC L N ++ FT +E+ ++ + Sbjct: 82 IDS--SINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVAR 139 Query: 140 IHRNK--ILHRDMKAANVLITRDGVLKLADFGLAR-AFSLAKNSQPNRYTNRV---VTLW 193 +H+ K I+HRD+K N+L+ G L DFG A F + N + + TL Sbjct: 140 LHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLS 199 Query: 194 YRPPEL--LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 YR PE+ L + D+W GC++ ++ + G ++ I +I Sbjct: 200 YRAPEMVNLYSGKIITTKADIWALGCLLYKL-CYFTLPFGESQ----VAICDGNFTIP-- 252 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 DN + + LI +L DP +R D Sbjct: 253 -----DNSRYSQDMHC-----------------------LIRYMLEPDPDKRPDIYQV-- 282 Query: 312 HDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQ-QSTNQSRNPATTNQT 366 +F + + + + P + + + Q + +P T +T Sbjct: 283 -SYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTET 337 >4Y83-A nrPDB Length = 332 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 113/310 (36%), Gaps = 57/310 (18%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALRE 66 + + + S + I +G FG+V+ A+ KT +++A K + ++ K Sbjct: 68 PWKLTYRNIGSDF-----IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD------- 115 Query: 67 IKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---KFTL 123 ++I +HEN+ L + V F E G + L Sbjct: 116 VEIQACFRHENIAELYGAVLWGET-----------VHLFMEAGEGGSVLEKLESCGPMRE 164 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 EI V + +L GL ++H K++H D+K +N++ + L DFGL+ + + Sbjct: 165 FEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKD 223 Query: 184 RYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 + Y PE++L R + D++ G + M T +P Sbjct: 224 LRGTEI----YMSPEVILC-RGHSTKADIYSLGATLIHMQTGTPPW-------------- 264 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 L ++ Q ++D A P +LI+ L +P R Sbjct: 265 ---------VKRYPRSAYPSYLYIIHKQAPPLEDI--ADDCSPGMRELIEASLERNPNHR 313 Query: 304 IDSDDALNHD 313 + D L H+ Sbjct: 314 PRAADLLKHE 323 >3SOC-A nrPDB Length = 322 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 129/303 (42%), Gaps = 39/303 (12%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 + L +G FG V+KA+ + VA+K +++++ E+ L +KHEN++ Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEY---EVYSLPGMKHENIL 81 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGL 137 I ++L+ F E G LS+ L + +E+ + + + GL Sbjct: 82 QFIGA----EKRGTSVDVDLWLITAFHE---KGSLSDFLKANVVSWNELCHIAETMARGL 134 Query: 138 YYIHR----------NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 Y+H I HRD+K+ NVL+ + +ADFGLA F K++ Sbjct: 135 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTH--G 192 Query: 188 RVVTLWYRPPELLLG----ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 +V T Y PE+L G +RD ID++ G ++ E+ +R G +++ L Sbjct: 193 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYML----- 247 Query: 244 LCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 E + E +++ + K ++ ++D + + + I++ D R Sbjct: 248 ----PFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEAR 303 Query: 304 IDS 306 + + Sbjct: 304 LSA 306 >4F0G-A nrPDB Length = 287 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 104/283 (36%), Gaps = 32/283 (11%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM-----ENEKEGFPITALREIKILQ 71 ++ E +IG+G FG V K R K VA+K +++ E E RE+ I+ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVM 130 L H N+V L + +V +F DL L + S R+M Sbjct: 79 NLNHPNIVKLYGLMHNPPR----------MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLM 128 Query: 131 QMLLNGLYYIHRNK--ILHRDMKAANVL---ITRDGVL--KLADFGLARAFSLAKNSQPN 183 + G+ Y+ I+HRD+++ N+ + + + K+ADFGL++ + Sbjct: 129 LDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ-------SVH 181 Query: 184 RYTNRVVTLWYRPPELL-LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + + + PE + E Y D + I+ + T ++ I+ Sbjct: 182 SVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFD-EYSYGKIKFIN 240 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 + P L +EL K + V++ Sbjct: 241 MIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKE 283 >5WNO-A nrPDB Length = 330 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 99/270 (36%), Gaps = 22/270 (8%) Query: 23 AKIGQGTFGEVFKA-----RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 K+G G FG VF R + VA+K + + L E + L+H+N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTD---QSQTDEMLEEATNMFRLRHDN 84 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 ++ +I C + +V + +L L E + +G Sbjct: 85 LLKIIGFCMHDDG--------LKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASG 136 Query: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 + Y+ + +++HRD+ NVL+ + +++ DFGL++ +S + + +V W Sbjct: 137 MQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIK-SGKVAIKWLAI 195 Query: 197 PELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 + + Y D+W G E+ T QG + + P + Sbjct: 196 E--IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNC-S 252 Query: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 D Y+ + + + R + L ++ Sbjct: 253 QDLYQELLRCWMADPKSRPGFEILYERFKE 282 >3ZZW-A nrPDB Length = 289 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 107/280 (38%), Gaps = 34/280 (12%) Query: 20 EKLAKIGQGTFGEVFKARHRKTG-----QKVALKKVLMENEKEGFPITALREIKILQLLK 74 + ++G+ FG+V+K Q VA+K + + E E + L+ Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP-LREEFRHEAMLRARLQ 70 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLL---------------SNVL 118 H NVV L+ + + ++F +C H DL L V Sbjct: 71 HPNVVCLLGVVTKD--------QPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVK 122 Query: 119 VKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + ++ + G+ Y+ + ++H+D+ NVL+ +K++D GL R A Sbjct: 123 SALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD 182 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQ 237 + N ++ + + PE ++ + + D+W G ++ E+++ G + Q Sbjct: 183 YYK--LLGNSLLPIRWMAPEAIMYGK-FSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDV 239 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKD 277 + +I P+ P + E ++ + KD Sbjct: 240 VEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKD 279 >5IKW-A nrPDB Length = 310 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 121/336 (36%), Gaps = 61/336 (18%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENV 78 + +G F VF R G + ALK++ + N + REI I++ L H+N+ Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPD--LNVCKREITIMKELSGHKNI 73 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-----FTLSEIKRVMQML 133 V ++ N +++ V E+ AG + N + K FT E+ ++ Sbjct: 74 VGYLDC------AVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDT 127 Query: 134 LNGLYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLA--RAFSLAKNS--QPNRYTN 187 + +H+ K I+HRD+K N+L+ G L DFG A + + K+ Sbjct: 128 CEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIK 187 Query: 188 RVVTLWYRPPEL--LLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 + TL YR PE+ L G + D+W GC++ ++ + G ++ I Sbjct: 188 KYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQ----VAICDGN 242 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 +I DN + LI +L DP R D Sbjct: 243 FTIP-------DNSRYSRNIHC-----------------------LIRFMLEPDPEHRPD 272 Query: 306 SDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAP 341 +F +D + + P Sbjct: 273 IFQV---SYFAFKFAAADCPVSNINNSSIPSALPEP 305 >2QKW-B nrPDB Length = 321 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 66/313 (21%), Positives = 123/313 (39%), Gaps = 36/313 (11%) Query: 5 YDSVECPFCD---EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI 61 ++S P D + ++ IG G FG+V+K R G KVALK+ E+ + Sbjct: 24 FESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKRRTPESSQGIEEF 82 Query: 62 TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLL---SNV 117 + L +H ++V+LI C + + L++ + E +L L Sbjct: 83 ETEI--ETLSFCRHPHLVSLIGFCDE--------RNEMILIYKYMENGNLKRHLYGSDLP 132 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 + + + + GL+Y+H I+HRD+K+ N+L+ + V K+ DFG+++ + Sbjct: 133 TMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGT-- 190 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 + Q + T TL Y PE + R D++ G ++ E+ + + + Sbjct: 191 ELDQTHLSTVVKGTLGYIDPEYFIKGRL-TEKSDVYSFGVVLFEVLCARSAIVQSLPREM 249 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 + L S + + L +K+ + L+ + K L Sbjct: 250 VNLAEWAVESHNNGQLEQIVDPNLADKIR---------PESLRKFGDTAV------KCLA 294 Query: 298 LDPAQRIDSDDAL 310 L R D L Sbjct: 295 LSSEDRPSMGDVL 307 >4JLC-A nrPDB Length = 657 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 58/221 (26%), Positives = 96/221 (43%), Gaps = 26/221 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG VF+ RH+KTG A+K + + +RE ++L+ L H+N+V L I Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 74 Query: 85 CRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV--KFTLSEIKRVMQMLLNGLYYIH 141 + + L+ +FC L +L SE V++ ++ G+ ++ Sbjct: 75 EEETTTRHKV------LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 128 Query: 142 RNKILHRDMKAANVL--ITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 N I+HRD+K N++ I DG KL DFG AR + ++ + T Y P Sbjct: 129 ENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-----QFVSLYGTEEYLHP 183 Query: 198 ELLL-------GERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 ++ ++ YG +DLW G T S + Sbjct: 184 DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRP 224 >4EUU-A nrPDB Length = 319 Score = 153 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 26/221 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG VF+ RH+KTG A+K + + +RE ++L+ L H+N+V L I Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 75 Query: 85 CRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV--KFTLSEIKRVMQMLLNGLYYIH 141 + + L+ +FC L +L SE V++ ++ G+ ++ Sbjct: 76 EEETTTRHKV------LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 142 RNKILHRDMKAANVL--ITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 N I+HR++K N++ I DG KL DFG AR + ++ + T Y P Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-----QFVSLYGTEEYLHP 184 Query: 198 ELLL-------GERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 ++ ++ YG +DLW G T S + Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 225 >3UIM-A nrPDB Length = 326 Score = 153 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 119/295 (40%), Gaps = 27/295 (9%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 + +G+G FG+V+K R G VA+K++ E +G + E++++ + H Sbjct: 30 DNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRL-KEERTQGGELQFQTEVEMISMAVHR 87 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLV---KFTLSEIKRVMQM 132 N++ L C T LV+ + +A L + +R+ Sbjct: 88 NLLRLRGFCMTPTERL--------LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALG 139 Query: 133 LLNGLYYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 GL Y+H + KI+HRD+KAAN+L+ + + DFGLA+ T Sbjct: 140 SARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVT---TAVR 196 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQ-----GNTEQHQLALISQL 244 T+ + PE L + D++G G ++ E+ T + + L + L Sbjct: 197 GTIGHIAPEYLSTGKS-SEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGL 255 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 E +VD Y+ E+ + + + + + P +++ ++L D Sbjct: 256 LKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVV-RMLEGD 309 >4EUT-A nrPDB Length = 396 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 26/221 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG VF+ RH+KTG A+K + + +RE ++L+ L H+N+V L I Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 75 Query: 85 CRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV--KFTLSEIKRVMQMLLNGLYYIH 141 + + L+ +FC L +L SE V++ ++ G+ ++ Sbjct: 76 EEETTTRHKV------LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 129 Query: 142 RNKILHRDMKAANVL--ITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 N I+HR++K N++ I DG KL DFG AR + ++ + T Y P Sbjct: 130 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-----QFVSLYGTEEYLHP 184 Query: 198 ELLL-------GERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 ++ ++ YG +DLW G T S + Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 225 >4M66-A nrPDB Length = 325 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 16/215 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 + +KL +G+G FG VF+A HR VA+K V + E+K + L++E Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW--------EVKAMVNLRNE 71 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 NV+ L+ + T+ ++ G LV F E+ L + R++Q ++ G Sbjct: 72 NVLLLLGV--TEDLQWDFVSGQ-ALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLG 128 Query: 137 LYYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLAR--AFSLAKNSQPNRYTNRVVTL 192 + Y+H +LHRD+K +N+L+ + KLADFGL+ S + + + + TL Sbjct: 129 MCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTL 188 Query: 193 WYRPPELLLG-ERDYGPPIDLWGAGCIMAEMWTRS 226 Y PELL D++ G ++ + Sbjct: 189 AYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >5XD6-A nrPDB Length = 305 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 51/239 (21%), Positives = 95/239 (39%), Gaps = 27/239 (11%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL 70 D Y + IG+G++G VF + +G+ A+KK+ + + L ++ ++ Sbjct: 16 ELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMV 71 Query: 71 QLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLS--------NVLVKF 121 L+ ENVV L+ C L +++ L +L Sbjct: 72 SRLRQENVVALLGYCVDGPLR--------VLAYEYAPNGSLHDILHGRKGVKGAQPGPVL 123 Query: 122 TLSEIKRVMQMLLNGLYYIHRN---KILHRDMKAANVLITRDGVLKLADFGLARAFSLAK 178 + + ++ GL Y+H ++HRD+K++NVL+ D V K+ADF L+ Sbjct: 124 SWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQ--APD 181 Query: 179 NSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 + T + T Y PE + D++ G ++ E+ T + + Q Sbjct: 182 MAARLHSTRVLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKPVDHTLPRGQ 239 >3LMG-A nrPDB Length = 344 Score = 150 bits (380), Expect = 7e-37, Method: Composition-based stats. Identities = 51/275 (18%), Positives = 102/275 (37%), Gaps = 23/275 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQK----VALKKVLMENEKEGFPITALREIKILQL 72 ++ KL +G G FG V K G+ V +K + ++ ++ F + I Sbjct: 31 TELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-GS 89 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQ 131 L H ++V L+ +C S+ LV + L + + Sbjct: 90 LDHAHIVRLLGLC---------PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGV 140 Query: 132 MLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 + G+YY+ + ++HR++ A NVL+ +++ADFG+A + + Y+ Sbjct: 141 QIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLL--PPDDKQLLYSEAKTP 198 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITP 250 + + E + Y D+W G + E+ T + G +LA + L Sbjct: 199 IKWMALESI-HFGKYTHQSDVWSYGVTVWELMTFGAEPYAG----LRLAEVPDLLEKGER 253 Query: 251 EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRD 285 P + ++Y + ++ K + Sbjct: 254 LAQPQICTIDVYMVMVKCWMIDENIRPTFKELANE 288 >3G2F-A nrPDB Length = 336 Score = 150 bits (379), Expect = 9e-37, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 127/322 (39%), Gaps = 54/322 (16%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ--L 72 ++ + L IG+G +G V+K + VA+K N + E I + L Sbjct: 11 DLDNLKLLELIGRGRYGAVYKGS--LDERPVAVKVFSFAN-----RQNFINEKNIYRVPL 63 Query: 73 LKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIK--RVM 130 ++H+N+ I + LV ++ + G L L T + R+ Sbjct: 64 MEHDNIARFI---VGDERVTADGRMEYLLVMEYYPN---GSLCKYLSLHTSDWVSSCRLA 117 Query: 131 QMLLNGLYYIH---------RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQ 181 + GL Y+H + I HRD+ + NVL+ DG ++DFGL+ + + + Sbjct: 118 HSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVR 177 Query: 182 PNRYTN----RVVTLWYRPPELLLGE------RDYGPPIDLWGAGCIMAEMWTRSP-IMQ 230 P N V T+ Y PE+L G +D++ G I E++ R + Sbjct: 178 PGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFP 237 Query: 231 GNT-EQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYA- 288 G + ++Q+A V N+ +E ++++ ++++ +A+ + A Sbjct: 238 GESVPEYQMA------------FQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAV 285 Query: 289 ---LDLIDKLLVLDPAQRIDSD 307 + I+ D R+ + Sbjct: 286 RSLKETIEDCWDQDAEARLTAQ 307 >6O8B-A nrPDB Length = 665 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 57/221 (25%), Positives = 95/221 (42%), Gaps = 26/221 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG VF+ RH+KTG A+K + + +RE ++L+ L H+N+V L I Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 81 Query: 85 CRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV--KFTLSEIKRVMQMLLNGLYYIH 141 + + L+ +FC L +L SE V++ ++ G+ ++ Sbjct: 82 EEETTTRHKV------LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 135 Query: 142 RNKILHRDMKAANVL--ITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 N I+HR++K N++ I DG KL DFG AR + ++ T Y P Sbjct: 136 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-----QFVELYGTEEYLHP 190 Query: 198 ELLL-------GERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 ++ ++ YG +DLW G T S + Sbjct: 191 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 231 >2H34-A nrPDB Length = 309 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 54/232 (23%), Positives = 91/232 (39%), Gaps = 13/232 (5%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALREIKILQLLKHEN 77 Y +G+G G+V++A + VALK + + F RE + L+ + Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 VV + + + G +Y+ + +++ + + L Sbjct: 96 VVPIHD--------FGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSAL 147 Query: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H HRD+K N+L++ D L DFG+A A + K +Q N V TL+Y P Sbjct: 148 DAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQ---LGNTVGTLYYMAP 204 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 E E D++ C++ E T SP QG+ A I+Q + Sbjct: 205 ERF-SESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >6NT9-A nrPDB Length = 742 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 57/221 (25%), Positives = 96/221 (43%), Gaps = 26/221 (11%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 +GQG VF+ RH+KTG A+K + + +RE ++L+ L H+N+V L I Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNHKNIVKLFAI 73 Query: 85 CRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV--KFTLSEIKRVMQMLLNGLYYIH 141 + + L+ +FC L +L SE V++ ++ G+ ++ Sbjct: 74 EEETTTRHKV------LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLR 127 Query: 142 RNKILHRDMKAANVL--ITRDGV--LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 N I+HR++K N++ I DG KL DFG AR + ++ + T Y P Sbjct: 128 ENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE-----QFVSLYGTEEYLHP 182 Query: 198 ELLL-------GERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 ++ ++ YG +DLW G T S + Sbjct: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 >2QLU-A nrPDB Length = 314 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 125/300 (41%), Gaps = 46/300 (15%) Query: 27 QGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICR 86 +G FG V+KA+ VA+K +++++ + REI +KHEN++ I Sbjct: 25 RGRFGCVWKAQLMND--FVAVKIFPLQDKQS---WQSEREIFSTPGMKHENLLQFIAA-- 77 Query: 87 TKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK--FTLSEIKRVMQMLLNGLYYIHR-- 142 + + ++L+ F + G L++ L T +E+ V + + GL Y+H Sbjct: 78 --EKRGSNLEVELWLITAFHD---KGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDV 132 Query: 143 ---------NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 I HRD K+ NVL+ D LADFGLA F K P +V T Sbjct: 133 PWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP--PGDTHGQVGTRR 190 Query: 194 YRPPELLLG----ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 Y PE+L G +RD ID++ G ++ E+ +R G +++ L Sbjct: 191 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYML----------- 239 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL---IDKLLVLDPAQRIDS 306 + + E+L+ V K+ +++ P L I++ D R+ + Sbjct: 240 -PFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >5E8V-A nrPDB Length = 316 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 56/317 (17%), Positives = 114/317 (35%), Gaps = 42/317 (13%) Query: 12 FCDEVSKYEKLAKIGQGTFGEVFKARHRKT----GQKVALKKVLMENEKEGFPITALREI 67 E+ E +G+G F EV+KA+ ++ + VA+K E E ++I Sbjct: 4 HNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYE---EYASWKTEKDI 60 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEI 126 LKHEN++ + T +L+ F + +L L+ + + ++ Sbjct: 61 FSDINLKHENILQFL----TAEERKTELGKQYWLITAFHAKGNLQEYLTRHV--ISWEDL 114 Query: 127 KRVMQMLLNGLYYIHR---------NKILHRDMKAANVLITRDGVLKLADFGLARAFSLA 177 +++ L G+ ++H I+HRD+K++N+L+ D L DFGL+ Sbjct: 115 RKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPT 174 Query: 178 KNSQPNRYTNRVVTLWYRPPELLLGERDY-----GPPIDLWGAGCIMAEMWTRSPIMQGN 232 + + +V T Y PE+L + D++ ++ EM +R Sbjct: 175 LSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC------ 228 Query: 233 TEQHQLALISQLCGSITP--EVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALD 290 + ++ P L + ++ + + Sbjct: 229 ------NAVGEVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCE 282 Query: 291 LIDKLLVLDPAQRIDSD 307 + + DP R+ + Sbjct: 283 TLTECWDHDPEARLTAQ 299 >6BFN-A nrPDB Length = 342 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 92/233 (39%), Gaps = 27/233 (11%) Query: 10 CPFCDE---VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKE--GFPITAL 64 P C+ + + KIG+G FG V++A R T A+K++ + E + L Sbjct: 12 WPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFL 69 Query: 65 REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLS---NVLVK 120 E++ L +H N+V+ C G LV+ F L L Sbjct: 70 TEVEQLSRFRHPNIVDFAGYCAQN--------GFYCLVYGFLPNGSLEDRLHCQTQACPP 121 Query: 121 FTLSEIKRVMQMLLNGLYYIH--RNKILHRDMKAANVLITRDGVLKLADFGLARA----- 173 + + ++ + ++H ++H D+K++NVL+ KL DFGLAR Sbjct: 122 LSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAG 181 Query: 174 FSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRS 226 S +++S R TL Y P E + R D + G ++ E Sbjct: 182 SSPSQSSMVARTQTVRGTLAYLPEEYIKTGRL-AVDTDTFSFGVVVLETLAGQ 233 >2Y4I-B nrPDB Length = 319 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 133/316 (42%), Gaps = 43/316 (13%) Query: 8 VECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI 67 + PF + E IG+G FG+V+ R +VA++ + +E + E RE+ Sbjct: 28 WDIPF----EQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREV 80 Query: 68 KILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEI 126 + +HENVV + C + + ++ C+ L ++ + + +++ Sbjct: 81 MAYRQTRHENVVLFMGACMSPP--------HLAIITSLCKGRTLYSVVRDAKIVLDVNKT 132 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGL-ARAFSLAKNSQPNRY 185 +++ Q ++ G+ Y+H ILH+D+K+ NV +G + + DFGL + + L + ++ Sbjct: 133 RQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKL 191 Query: 186 TNRVVTLWYRPPELLLG--------ERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ 237 + L + PE++ + + D++ G I E+ R + + Sbjct: 192 RIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAE-- 249 Query: 238 LALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 A+I Q+ + P + E+ + L +++ + +D+++KL Sbjct: 250 -AIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKL------MDMLEKLPK 302 Query: 298 LDPAQRIDSDDALNHD 313 + +R+ H Sbjct: 303 RN--RRLS------HP 310 >5AR8-A nrPDB Length = 326 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 59/302 (19%), Positives = 116/302 (38%), Gaps = 31/302 (10%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKV-LMENEKEGFPITALREIKILQLLKHENVVN 80 L + +G G V ARH +VA+K + + + LRE +IL + ++ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT---LSEIKRVMQMLLNGL 137 ++ IC + +V ++ + L + ++ R++ + G+ Sbjct: 97 ILGICNEPE--------FLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 148 Query: 138 YYIHRNK--ILHRDMKAANVLITRDGVLKLADFGLAR-AFSLAKNSQPNRYTNRVVTLWY 194 Y+H +LH D+K N+L+ + +K+ADFGL++ S+ ++ T+ Y Sbjct: 149 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIY 208 Query: 195 RPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQ-LALISQLCGSITPE 251 PPE + D++ I E+ +R + T Q + +SQ + E Sbjct: 209 MPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINE 268 Query: 252 VWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR----IDSD 307 D + L++ + D + + L+ L+P R I Sbjct: 269 ESLPYDIPHRARMISLIESGWAQNPDERPS---------FLKCLIELEPVLRTFEEITFL 319 Query: 308 DA 309 +A Sbjct: 320 EA 321 >3SV0-A nrPDB Length = 483 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 108/293 (36%), Gaps = 24/293 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +K+ KIG G+FGE++ + +T ++VA+K +EN K P L E KI ++L+ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHP-QLLYESKIYRILQG- 61 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 + LV D L L + K +L + + ++N Sbjct: 62 ------GTGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINR 115 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRY---TNRVV 190 + ++H LHRD+K N L+ R + + DFGLA+ + Q Y N Sbjct: 116 VEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTG 175 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLCGS 247 T Y LG DL G ++ S QG T++ + IS+ + Sbjct: 176 TARYASVNTHLGIEQ-SRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVA 234 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL-IDKLLVLD 299 + E E + + K R DL I + D Sbjct: 235 TSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKR--LFRDLFIREGFQFD 285 >4MWI-A nrPDB Length = 294 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 106/283 (37%), Gaps = 41/283 (14%) Query: 34 FKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVVNLIEICRTKASP 91 +K + + VA+K T +EIK ++ + N++ + IC + Sbjct: 41 YKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDET-- 96 Query: 92 YNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKI--LHRD 149 +V ++CE L + TL + ++ GLY +H ++ LH Sbjct: 97 --VTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGK 154 Query: 150 MKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP-ELLLGERDYGP 208 ++++N L+T+ +KLA F L + + T+RV + Y P EL Y Sbjct: 155 IRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDV 214 Query: 209 PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELV 268 +++ G ++ E+ T QG N E KL V Sbjct: 215 KSEIYSFGIVLWEIATGDIPFQG-------------------------CNSEKIRKLVAV 249 Query: 269 KGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 K Q+ + + + ++ID+ DP+ R D+ L Sbjct: 250 KRQQEPLGEDCPS-----ELREIIDECRAHDPSVRPSVDEILK 287 >4TN6-A nrPDB Length = 318 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 104/274 (37%), Gaps = 21/274 (7%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 ++Y KIG G+FG+++ G++VA+K +E K P + E KI ++++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHI-ESKIYKMMQG- 61 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 + +V + L L + KF+L + + +++ Sbjct: 62 ------GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISR 115 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRY---TNRVV 190 + YIH +HRD+K N L+ + ++ + DFGLA+ + A+ Q Y N Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTG 175 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLCGS 247 T Y LG DL G ++ S QG T++ + IS+ S Sbjct: 176 TARYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMS 234 Query: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKA 281 EV E L + + K Sbjct: 235 TPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSY 268 >5FQD-C nrPDB Length = 341 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 111/273 (40%), Gaps = 25/273 (9%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 KY+ + KIG G+FG+++ A + G++VA+K +E++K P L E K+ ++L+ Sbjct: 19 GKYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHP-QLLYESKLYKILQG- 73 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 + Y + K LV D L L + +FT+ + + +++ Sbjct: 74 ------GVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISR 127 Query: 137 LYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRY---TNRVV 190 + Y+H +HRD+K N L+ L L DFGLA+ + + Q Y N Sbjct: 128 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTG 187 Query: 191 TLWYRPPELLLGERDYGPPIDLWGAG-CIMAEMWTRSPIMQ----GNTEQHQLALISQLC 245 T Y LG D+ G +M + R+ + T++ + IS+ Sbjct: 188 TARYASINAHLGIEQ-SRRDDMESLGYVLMY--FNRTSLPWQGLKAATKKQKYEKISEKK 244 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 S EV E L +G + + Sbjct: 245 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPD 277 >4BTK-A nrPDB Length = 337 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 98/234 (41%), Gaps = 19/234 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +++ L KIG G FGE+++A T + VALK + K+ + E+ +L+ L+ + Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM----EVAVLKKLQGK 111 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQMLLN 135 + +CR N Y+V +LA L + FTLS R+ + +L Sbjct: 112 D-----HVCRFIGCGRNEKFN--YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILE 164 Query: 136 GLYYIHRNKILHRDMKAANV----LITRDGVLKLADFGLARAF--SLAKNSQPNRYTNRV 189 + IH LHRD+K +N L + + DFGLAR + + P Sbjct: 165 SIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 224 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 T+ Y R+ G DLW ++ E + ++ Q+ +I + Sbjct: 225 GTVRYAS-VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >4NFN-A nrPDB Length = 309 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 58/234 (24%), Positives = 98/234 (41%), Gaps = 19/234 (8%) Query: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76 +++ L KIG G FGE+++A T + VALK + K+ + E+ +L+ L+ + Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKM----EVAVLKKLQGK 76 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQMLLN 135 + +CR N Y+V +LA L + FTLS R+ + +L Sbjct: 77 D-----HVCRFIGCGRNEKFN--YVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILE 129 Query: 136 GLYYIHRNKILHRDMKAANV----LITRDGVLKLADFGLARAF--SLAKNSQPNRYTNRV 189 + IH LHRD+K +N L + + DFGLAR + + P Sbjct: 130 SIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 189 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 T+ Y R+ G DLW ++ E + ++ Q+ +I + Sbjct: 190 GTVRYAS-VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >4M69-B nrPDB Length = 283 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 93/236 (39%), Gaps = 14/236 (5%) Query: 31 GEVFKARHRKTGQKVALKKVLMENEKE--GFPITALREIKILQLLKHENVVNLIEICRTK 88 +++ + ++ V +K + T EIK ++ N++ + IC + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 89 ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHR 148 +V ++CE L + T+S ++ GLY +H ++ LHR Sbjct: 81 T----VKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHR 136 Query: 149 DMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG-ERDYG 207 ++ +++ L+ +KLA F L++ + + + R + Y PE L Y Sbjct: 137 NISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYD 196 Query: 208 PPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS-----QLCGSITPEVWPNVDN 258 +++ G ++ E+ T +G + L++ + G PE+ + N Sbjct: 197 IKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIIN 252 >5VC6-A nrPDB Length = 289 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 60/326 (18%), Positives = 109/326 (33%), Gaps = 74/326 (22%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL-K 74 +++ +L KIG G FG VFK R G A+K+ ALRE+ +L + Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQ 69 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSN---VLVKFTLSEIKRVM 130 H +VV + + ++C LA +S ++ F +E+K ++ Sbjct: 70 HSHVVRYFSAWAED--------DHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLL 121 Query: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVL-------------------KLADFGLA 171 + GL YIH ++H D+K +N+ I+R + K+ D G Sbjct: 122 LQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHV 181 Query: 172 RAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG 231 S + + + + E+L + P D++ + P+ + Sbjct: 182 TRISSPQVEEGDS--------RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPR- 232 Query: 232 NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 Q I Q P+V +L Sbjct: 233 --NGDQWHEIRQGRLPRIPQVL-------------------------------SQEFTEL 259 Query: 292 IDKLLVLDPAQRIDSDDALNHDFFWS 317 + ++ DP +R + + H S Sbjct: 260 LKVMIHPDPERRPSAMALVKHSVLLS 285 >4BTF-A nrPDB Length = 469 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 93/236 (39%), Gaps = 14/236 (5%) Query: 31 GEVFKARHRKTGQKVALKKVLMENEKE--GFPITALREIKILQLLKHENVVNLIEICRTK 88 +++ + ++ V +K + T EIK ++ N++ + IC + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 89 ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHR 148 +V ++CE L + T+S ++ GLY +H ++ LHR Sbjct: 267 T----VKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHR 322 Query: 149 DMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG-ERDYG 207 ++ +++ L+ +KLA F L++ + + + R + Y PE L Y Sbjct: 323 NISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYD 382 Query: 208 PPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS-----QLCGSITPEVWPNVDN 258 +++ G ++ E+ T +G + L++ + G PE+ + N Sbjct: 383 IKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIIN 438 >5X1R-A nrPDB Length = 302 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 96/247 (38%), Gaps = 32/247 (12%) Query: 4 QYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP--- 60 + +S P +++E IG+G FG V++A + + +A+K+ + + + Sbjct: 8 KPNSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLS 67 Query: 61 ----------------ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFD 104 + ++E ++L H +++++ + Y + Sbjct: 68 IGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQF------- 120 Query: 105 FCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLK 164 + L L + K + I+R++ L + + IH+ LHRD+ N+ I + Sbjct: 121 YSGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV 180 Query: 165 LADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERD--YGPPIDLWGAGCIMAEM 222 L DFG AR + + T V+ + P E D GP D++ G ++ + Sbjct: 181 LLDFGSARK----EIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTL 236 Query: 223 WTRSPIM 229 SP Sbjct: 237 IVGSPPP 243 >3HNG-A nrPDB Length = 360 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 36/160 (22%), Positives = 70/160 (43%), Gaps = 6/160 (3%) Query: 117 VLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 T+ ++ + G+ ++ K +HRD+ A N+L++ + V+K+ DFGLAR Sbjct: 192 YKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIY- 250 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT--RSPIMQGNTE 234 KN R + + L + PE + ++ Y D+W G ++ E+++ SP + Sbjct: 251 -KNPDYVRKGDTRLPLKWMAPESIF-DKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMD 308 Query: 235 QHQLALISQLCGSITPEVW-PNVDNYELYEKLELVKGQKR 273 + + + + PE P + L K + R Sbjct: 309 EDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPR 348 Score = 72.3 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 19/121 (15%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKA-----RHRKTGQKVALKKVLMENEKEGF 59 YD+ + F E + + +G+G FG+V +A + T + VA+K +L E Sbjct: 17 YDASKWEFARE--RLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVK-MLKEGATASE 73 Query: 60 PITALREIKILQLLKHE-NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVL 118 + E+KIL + H NVVNL+ C + G + ++ ++C++ G LSN L Sbjct: 74 YKALMTELKILTHIGHHLNVVNLLGACTKQG-------GPLMVIVEYCKY---GNLSNYL 123 Query: 119 V 119 Sbjct: 124 K 124 >5L2Q-C nrPDB Length = 320 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 58/309 (18%), Positives = 108/309 (34%), Gaps = 65/309 (21%) Query: 34 FKARHRKTGQKVALKKVLME---------NEKEGFPITALREIKILQLLKHEN-VVNLIE 83 AR T LK + +E E+ + E +L LL ++ VV+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 84 ICRTKASPYNRC----------KGSIYLVFD-FCEHDLAGLLSNVL---------VKFTL 123 + + + K I LV D C HD + ++++ + + Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV-LKLADFGLARAFSLAKNSQP 182 E + ++ + +H+ I+HRD+K N+++ + + + +F L + S+ Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLV----SEG 208 Query: 183 NRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 + ++ + Y P++L G G P D+W G ++ M + Q I Sbjct: 209 DLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIK 268 Query: 243 QLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ 302 +I + + LI KLLVLDP Q Sbjct: 269 AAEYTIPED------------------------------GRVSENTVCLIRKLLVLDPQQ 298 Query: 303 RIDSDDALN 311 R+ + D L Sbjct: 299 RLAAADVLE 307 >2CMW-A nrPDB Length = 310 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 103/286 (36%), Gaps = 24/286 (8%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 KIG G FGE+ ++ T + VA+K +E K P L E + + L Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLGSA--- 55 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYY 139 + + C +V + L L FTL + + LL+ + Y Sbjct: 56 ---GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEY 112 Query: 140 IHRNKILHRDMKAANVLITRDG-----VLKLADFGLARAF---SLAKNSQPNRYTNRVVT 191 +H +++RD+K N LI R G V+ + DFGLA+ + K+ + + T Sbjct: 113 VHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 172 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLCGSI 248 Y LG ++ DL G + S QG +T + + I + Sbjct: 173 ARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNT 231 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDK 294 E E+ L V+ + ++ DL +K Sbjct: 232 PIEALCENFPEEMATYLRYVR--RLDFFEKPDYEYLRTLFTDLFEK 275 >3VHK-A nrPDB Length = 368 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 73/183 (39%), Gaps = 13/183 (7%) Query: 121 FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 TL + + G+ ++ K +HRD+ A N+L++ V+K+ DFGLAR K+ Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY--KDP 254 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLA 239 R + + L + PE + +R Y D+W G ++ E+++ + G + Sbjct: 255 DYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE-- 311 Query: 240 LISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLD 299 + T P+ E+Y+ + + + V + LL + Sbjct: 312 -FCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH------LGNLLQAN 364 Query: 300 PAQ 302 Q Sbjct: 365 AQQ 367 Score = 72.3 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 17/124 (13%) Query: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKA----RHR-KTGQKVALKKVLMENEKEGF 59 YD+ + F + + +G+G FG+V +A + T + VA+K +L E Sbjct: 19 YDASKWEFPR--DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVK-MLKEGATHSE 75 Query: 60 PITALREIKILQLLKHE-NVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNV 117 + E+KIL + H NVVNL+ C G + ++ +FC+ +L+ L + Sbjct: 76 HRALMSELKILIHIGHHLNVVNLLGACTKPG-------GPLMVIVEFCKFGNLSTYLRSK 128 Query: 118 LVKF 121 +F Sbjct: 129 RNEF 132 >2CHL-A nrPDB Length = 351 Score = 127 bits (320), Expect = 7e-30, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 100/286 (34%), Gaps = 22/286 (7%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 + KIG G FGE+ ++ T + VA+K +E K P L E + + L Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGS-- 84 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + + C +V + L L F+L + + L++ + Sbjct: 85 -----GDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM 139 Query: 138 YYIHRNKILHRDMKAANVLITRDG-----VLKLADFGLARAF---SLAKNSQPNRYTNRV 189 Y+H +++RD+K N LI R G V+ + DF LA+ + K+ + + Sbjct: 140 EYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLT 199 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T Y LG ++ DL G + S QG + L Q G Sbjct: 200 GTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQG-LKADTLKERYQKIGDTK 257 Query: 250 PEVWPNVDNYELYEKLELVKGQKR-KVKDRLKAYVRDPYALDLIDK 294 V E ++ +R ++ DL D+ Sbjct: 258 RATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 303 >4NT4-A nrPDB Length = 312 Score = 127 bits (319), Expect = 9e-30, Method: Composition-based stats. Identities = 63/296 (21%), Positives = 105/296 (35%), Gaps = 37/296 (12%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH-- 75 + KIG G FGE+ ++ + VA+K ME K P L E + +LL Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK---MEPMKSKAPQLHL-EYRFYKLLGSHA 68 Query: 76 ---ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM 132 + + I T YN +V + L L + KF+L + + + Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNA------MVLELLGLSLEDLFNICARKFSLKTVLMIAKQ 122 Query: 133 LLNGLYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARA---FSLAKNSQPNR 184 LL+ + Y+H +++RD+K N LI R + + DFGLA+ ++ Sbjct: 123 LLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 182 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALI 241 + + T Y +G R+ DL G + S QG +T + + I Sbjct: 183 HKSLTGTARYMSINTHMG-REQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 241 Query: 242 SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLV 297 + EV + E L V+ D + +L Sbjct: 242 GDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY----------DFLRRLFQ 287 >5J0A-A nrPDB Length = 300 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 111/310 (35%), Gaps = 43/310 (13%) Query: 21 KLAKIGQGTFGE---VFKARHRKTGQK---VALKKVLM---ENEKEGFPITALREIKILQ 71 + K+G FG V+ + G A+KK+ ++ + + + E KIL+ Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFC-EHDLAGLLSNV----LVKFTLSEI 126 L H N+V + GS+ L ++ E L L+ F + I Sbjct: 70 SLHHPNIVGY-------RAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAII 122 Query: 127 KRVMQMLLNGLYYIHR-NKILHRDMKAANVLITRDG-VLKLADFGLARAFSLAKNSQPNR 184 +V + GL Y+H+ K+LH D+K++NV+I D +K+ D G++ Sbjct: 123 LKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPE 182 Query: 185 YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQL 244 + T ++P E + D++ G + EM T S + L + Sbjct: 183 AC-YIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP--------HINLSNDD 233 Query: 245 CGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 + D+ Y L + D V ++L DP R Sbjct: 234 DDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKV-----IELFSVCTNEDPKDRP 288 Query: 305 DSD---DALN 311 + +AL Sbjct: 289 SAAHIVEALE 298 >2C47-A nrPDB Length = 313 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 63/289 (21%), Positives = 104/289 (35%), Gaps = 27/289 (9%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HE 76 + KIG G FGE+ ++ T + VA+K +E K P L E + + L E Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLSATE 60 Query: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 V + + C +V + L L FTL + + L+ Sbjct: 61 GVPQVYY--------FGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITR 112 Query: 137 LYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAF---SLAKNSQPNRYTNR 188 + Y+H +++RD+K N L+ R G + + DFGLA+ + K+ + + Sbjct: 113 MEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSL 172 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLC 245 T Y LG ++ DL G + S QG +T + + I Sbjct: 173 TGTARYMSINTHLG-KEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 231 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDK 294 + EV E+ L V+ K + DL D+ Sbjct: 232 RATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRK--LFTDLFDR 278 >4JRN-A nrPDB Length = 372 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 96/317 (30%), Gaps = 75/317 (23%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPI-TALREIKILQLLK-------- 74 +G G F V++A +T +++A+K + E E + RE + Sbjct: 75 PLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDA 134 Query: 75 --------HENVVNLIE---ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV---- 119 +VV L R + +L+ E D++ ++S V Sbjct: 135 QESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASV 194 Query: 120 ---KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL 176 +F L + + + + I+H D+K AN L+ +DG L L DFG R Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI--- 251 Query: 177 AKNSQPNRYTNRVVTLWYRPPELLLGERD--YGPPIDLWGAGCIMAEMWTRSPIMQGNTE 234 N + T Y PPE Y P D W G + +W + + Sbjct: 252 -----NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGI 306 Query: 235 QHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDK 294 L DLI Sbjct: 307 WDYLHF--------------------------------------ADCPSTPELVQDLIRS 328 Query: 295 LLVLDPAQRIDSDDALN 311 LL DP +R+ AL Sbjct: 329 LLNRDPQKRMLPLQALE 345 >5VDK-A nrPDB Length = 297 Score = 125 bits (313), Expect = 4e-29, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 106/324 (32%), Gaps = 82/324 (25%) Query: 16 VSKYEK----LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQ 71 S+YEK + KIG G FG V+K R G A+K+ + + +AL E+ Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHA 69 Query: 72 LL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLV---KFTLSEI 126 +L H +VV + + ++C L +S F ++ Sbjct: 70 VLGHHPHVVRYYSSWAED--------DHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKL 121 Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANV-----------------------LITRDGVL 163 K ++ + GL YIH + ++H D+K +N+ ++ + + Sbjct: 122 KDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMY 181 Query: 164 KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMW 223 K+ D G A + + K + + + E+L + + P D++ G +A Sbjct: 182 KIGDLGHATSINKPKVEEGDS--------RFLANEILQEDYRHLPKADIFALGLTIAVAA 233 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 + H + KG V L Sbjct: 234 GAESLPTNGAAWHHIR-----------------------------KGNFPDVPQELSESF 264 Query: 284 RDPYALDLIDKLLVLDPAQRIDSD 307 L+ ++ D QR + Sbjct: 265 SS-----LLKNMIQPDAEQRPSAA 283 >5X18-A nrPDB Length = 295 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 101/278 (36%), Gaps = 25/278 (8%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH-EN 77 Y+ KIG+G+FG +F+ + G VA+K ++ E K ++L N Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKF----EPRKTEAPQLRDEYKTYKILNGTPN 64 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + A + + LV D L L KF++ + +V ++ + Sbjct: 65 I--------PYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLI 116 Query: 138 YYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAFSLAKNSQPNRYTNR---V 189 +H + +++RD+K N LI R G + L DFG+A+ + K Q Y + Sbjct: 117 EDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLS 176 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLCG 246 T Y LG R+ D+ G + QG + + I + Sbjct: 177 GTARYMSINTHLG-REQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKR 235 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVR 284 S + LE+V+ + + Y + Sbjct: 236 STNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRK 273 >5CEK-A nrPDB Length = 263 Score = 124 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 43/288 (14%), Positives = 99/288 (34%), Gaps = 55/288 (19%) Query: 33 VFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPY 92 V +A TG+++ K +++ ++ QL H N+ ++E+ + Y Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYI-------QLPSHSNITGIVEVILGETKAY 77 Query: 93 NRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKA 152 + D+ + + + E R+ + +++ + + H++ I+ D+K Sbjct: 78 VFFEKDF--------GDMHSYVRS-RKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKL 128 Query: 153 ANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY-GPP 209 + + L+L + + + + +++ Y PE+L Y G Sbjct: 129 RKFVFSTEERTQLRL----ESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKA 184 Query: 210 IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVK 269 D+W G ++ + + + I + I + Sbjct: 185 ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHI----------------- 227 Query: 270 GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 P A LI LL +P++R+ + + L H +F S Sbjct: 228 ---------------SPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 >6DC0-A nrPDB Length = 292 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 43/288 (14%), Positives = 99/288 (34%), Gaps = 55/288 (19%) Query: 33 VFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPY 92 V +A TG+++ K +++ ++ QL H N+ ++E+ + Y Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYI-------QLPSHSNITGIVEVILGETKAY 74 Query: 93 NRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKA 152 + D+ + + + E R+ + +++ + + H++ I+ D+K Sbjct: 75 VFFEKDF--------GDMHSYVRS-RKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKL 125 Query: 153 ANVLIT--RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY-GPP 209 + + L+L + + + + +++ Y PE+L Y G Sbjct: 126 RKFVFSTEERTQLRL----ESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKA 181 Query: 210 IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVK 269 D+W G ++ + + + I + I + Sbjct: 182 ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHI----------------- 224 Query: 270 GQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS 317 P A LI LL +P++R+ + + L H +F S Sbjct: 225 ---------------SPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 >4RT7-A nrPDB Length = 415 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 37/170 (21%), Positives = 69/170 (40%), Gaps = 4/170 (2%) Query: 115 SNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAF 174 L T ++ + G+ ++ +HRD+ A NVL+T V+K+ DFGLAR Sbjct: 234 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI 293 Query: 175 SLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNT 233 ++ ++ R R+ W PE L E Y D+W G ++ E+++ G Sbjct: 294 -MSDSNYVVRGNARLPVKW-MAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP 350 Query: 234 EQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYV 283 + Q + + + Y + + +KR L +++ Sbjct: 351 VDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 83.9 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 37/126 (29%), Positives = 57/126 (45%), Gaps = 17/126 (13%) Query: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARH---RKTGQ--KVALKKVLMENEKE 57 ++Y+ + + E +G G FG+V A KTG +VA+K +L E Sbjct: 52 REYEY-DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVK-MLKEKADS 109 Query: 58 GFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLS 115 + E+K++ L HEN+VNL+ C G IYL+F++C DL L Sbjct: 110 SEREALMSELKMMTQLGSHENIVNLLGACT--------LSGPIYLIFEYCCYGDLLNYLR 161 Query: 116 NVLVKF 121 + KF Sbjct: 162 SKREKF 167 >4XHH-A nrPDB Length = 403 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 103/283 (36%), Gaps = 23/283 (8%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 K+ KIG G+FG+++ + +G++VA+ +E+ + P E ++ + L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY-ESRVYKYLSG-- 61 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + + R +V D L L + KF+ + + ++ + Sbjct: 62 -----GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRV 116 Query: 138 YYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLA---RAFSLAKNSQPNRYTNRVVT 191 YIH +HRD+K N L+ R + + DFGL+ R F+ ++ + T Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLCGSI 248 Y LG DL G ++ S QG T++ + I + I Sbjct: 177 ARYASVNTHLGIEQ-SRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 + E E E + + K + R DL Sbjct: 236 SVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLAR--LFKDL 276 >4XHL-A nrPDB Length = 394 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 104/283 (36%), Gaps = 23/283 (8%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 K+ KIG G+FG+++ + +G++VA+ +E+ + P E ++ + L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY-ESRVYRYLSG-- 61 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + + R +V D L L + +F+ + + + + Sbjct: 62 -----GVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRI 116 Query: 138 YYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLA---RAFSLAKNSQPNRYTNRVVT 191 YIH +HRD+K N L+ R + + DFGL+ R F+ ++ + T Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLCGSI 248 Y LG DL G ++ S QG T++ + I + ++ Sbjct: 177 ARYASVNTHLGIEQ-SRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNV 235 Query: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 + E + E E + K K ++ DL Sbjct: 236 SVETLCSGLPLEFQEYMAYCKNL--KFDEKPDYLFLARLFKDL 276 >1CSN-A nrPDB Length = 298 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 95/265 (35%), Gaps = 27/265 (10%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y+ +IG+G+FG +F+ + Q+VA+K + E + + Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF----EPRRSDAPQLRDEYRTYK------- 60 Query: 79 VNLIEICRTKASPYNRCKGSIY--LVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136 L+ C + Y + ++ LV D L LL KF++ + + +L Sbjct: 61 --LLAGCTGIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLAR 118 Query: 137 LYYIHRNKILHRDMKAANVLITRDGV-----LKLADFGLARAFSLAKNSQPNRYTNR--- 188 + IH +++RD+K N LI R + + DFG+ + + Q Y + Sbjct: 119 VQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNL 178 Query: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG---NTEQHQLALISQLC 245 T Y LG R+ DL G + S QG T + + I + Sbjct: 179 SGTARYMSINTHLG-REQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKK 237 Query: 246 GSITPEVWPNVDNYELYEKLELVKG 270 S E Y+ + + Sbjct: 238 QSTPLRELCAGFPEEFYKYMHYARN 262 >5M07-A nrPDB Length = 276 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 44/217 (20%), Positives = 79/217 (36%), Gaps = 34/217 (15%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME-NEKEGFPITALREIKILQLLKHEN 77 Y + +G GEV+ +H ALK + + F RE ++ L H + Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA--GLLSNVLVKFTLSEIKRVMQMLLN 135 ++ + + G +++ D+ + A + + E+ ++ + Sbjct: 92 ILEVHD--------RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAG 143 Query: 136 GLYYIHRNKILHRDMKAANVLITR----DGVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 L Y H+ +LHRD+ ANV++T D + LADFG+A Sbjct: 144 ALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------------ 185 Query: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 Y PEL G D D + ++ +P Sbjct: 186 PSYPAPELSAGA-DVDGRADQYALALTAIHLFAGAPP 221 >2PZI-A nrPDB Length = 681 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 104/301 (34%), Gaps = 56/301 (18%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKI 69 P +YE I G G ++ A R G+ V LK ++ + E + + Sbjct: 74 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQF 132 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 L + H ++V + + Y+V ++ + K ++E Sbjct: 133 LAEVVHPSIVQIFNFVEHTDRHGDPVG---YIVMEYVGGQSLK--RSKGQKLPVAEAIAY 187 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + +L L Y+H +++ D+K N+++T + LKL D G S+ N + Sbjct: 188 LLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLG--------AVSRINSFGYLY 238 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T ++ PE++ D++ G +A + T + L Sbjct: 239 GTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGRYVDGL----------- 284 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 PE P + Y+ Y + L+ + + DP QR + + Sbjct: 285 PEDDPVLKTYDSYGR--------------------------LLRRAIDPDPRQRFTTAEE 318 Query: 310 L 310 + Sbjct: 319 M 319 >4Y12-A nrPDB Length = 375 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 104/301 (34%), Gaps = 56/301 (18%) Query: 11 PFCDEVSKYEKLAKIGQGTFGEVFKARHRK-TGQKVALKKVLMENEKEGFPITALREIKI 69 P +YE I G G ++ A R G+ V LK ++ + E + + Sbjct: 113 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAE-RQF 171 Query: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRV 129 L + H ++V + + Y+V ++ + K ++E Sbjct: 172 LAEVVHPSIVQIFNFVEHTDRHGDPVG---YIVMEYVGGQSLK--RSKGQKLPVAEAIAY 226 Query: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 + +L L Y+H +++ D+K N+++T + LKL D G S+ N + Sbjct: 227 LLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLG--------AVSRINSFGYLY 277 Query: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 T ++ PE++ D++ G +A + T + L Sbjct: 278 GTPGFQAPEIVRTGP--TVATDIYTVGRTLAAL-TLDLPTRNGRYVDGL----------- 323 Query: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 PE P + Y+ Y + L+ + + DP QR + + Sbjct: 324 PEDDPVLKTYDSYGR--------------------------LLRRAIDPDPRQRFTTAEE 357 Query: 310 L 310 + Sbjct: 358 M 358 >4L68-A nrPDB Length = 340 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 97/265 (36%), Gaps = 24/265 (9%) Query: 31 GEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKAS 90 G +KA G +A+K + E E+ L L+H N+ L+ C + Sbjct: 54 GTTYKA-LLPDGSALAVKHLSTCKLGER---EFRYEMNQLWELRHSNLAPLLGFCVVEEE 109 Query: 91 PYNRCKGSIYLVFDFC-EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR---NKIL 146 + LV+ + L LL + + S R+ GL ++H IL Sbjct: 110 KF--------LVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPIL 161 Query: 147 HRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY 206 H+++ ++ +LI D ++ D GLAR + N++ + T + Y PE Sbjct: 162 HQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLA 220 Query: 207 GPPIDLWGAGCIMAEMWTRSPIMQGN-------TEQHQLALISQLCGSITPEVWPNVDNY 259 D++G G ++ E+ T + G QL ++ + + + Sbjct: 221 SLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDE 280 Query: 260 ELYEKLELVKGQKRKVKDRLKAYVR 284 E+ + +E+ + + Sbjct: 281 EISKFVEIALNCVSSRPKERWSMFQ 305 >5USZ-A nrPDB Length = 289 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 104/291 (35%), Gaps = 42/291 (14%) Query: 23 AKIGQGTFGEVFKARHRKTGQ-------KVALKKVLMENEKEGFPITALREIKILQLLKH 75 +GQGTF ++FK R+ G +V LK + + + + ++ L H Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASMMSKLSH 71 Query: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCE-HDLAGLLSNVLVKFTLSEIKRVMQMLL 134 +++V +C C LV +F + L L + V + L Sbjct: 72 KHLVLNYGVC--------VCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLA 123 Query: 135 NGLYYIHRNKILHRDMKAANVLI--------TRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++++ N ++H ++ A N+L+ +KL+D G++ Q Sbjct: 124 AAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER--- 180 Query: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 + + PPE + ++ D W G + E+ + G+ L +L Sbjct: 181 -----IPWVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSALDSQRKLQF 230 Query: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYAL---DLIDK 294 P EL + + + +A +RD +L DL+ + Sbjct: 231 YEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPDLVPR 281 >5OAT-A nrPDB Length = 411 Score = 104 bits (259), Expect = 8e-23, Method: Composition-based stats. Identities = 56/342 (16%), Positives = 111/342 (32%), Gaps = 86/342 (25%) Query: 16 VSKYEKLAKIGQGTFGEVFKARHRKT-----GQKVALKKVLMENEKEGFPITALR----- 65 ++ I +GT G V+ A+ + ALK + + +E Sbjct: 10 LNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRET 69 Query: 66 ---------------EIKILQLLKH----ENVVNLIEICRT--------KASPYNRCKG- 97 EI++ KH N+V + + + P + Sbjct: 70 VPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM 129 Query: 98 SIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI 157 S++L+ + +L LS T + + G+ ++ + I HRD+K+ N+L+ Sbjct: 130 SLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLE---GVAHMTAHGIAHRDLKSDNLLL 186 Query: 158 T----RDGVLKLADFG--LARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERD------ 205 +L ++DFG LA + + ++ PE++ + Sbjct: 187 DTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLN 246 Query: 206 YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL 265 Y DLW G I E++ G + + Sbjct: 247 YS-KADLWAVGAIAYEIFNCHNPFYGPSR---------------------------LKNF 278 Query: 266 ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307 +G K+ D + ++ L+ LL +P +R+D + Sbjct: 279 NYKEGDLPKLPDEVPTVIQA-----LVANLLKRNPNKRLDPE 315 >4L00-A nrPDB Length = 304 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 91/278 (32%), Gaps = 60/278 (21%) Query: 38 HRKTGQKVALKKVLM--ENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRC 95 T ++ +K +L + + +++ + H+++V L +C Sbjct: 52 DEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENI--- 108 Query: 96 KGSIYLVFDFCEHDLAGLLSNVLVK-FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 +V +F E L + T +V + L + L Y+ ++H ++ N Sbjct: 109 -----MVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKN 163 Query: 155 VLITRDGV-------LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYG 207 +L+ R+G+ +KL+D G+ R+ + PE + ++ Sbjct: 164 LLLAREGIDSECGPFIKLSDPGI-----PITVLSRQECIERIP---WIAPECVEDSKNLS 215 Query: 208 PPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLE 266 D W G + E+ + + + L EK Sbjct: 216 VAADKWSFGTTLWEICYNGEIP---------------------------LKDKTLIEKER 248 Query: 267 LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRI 304 + + R V K DL+ + + DP QR Sbjct: 249 FYESRCRPVTPSCK------ELADLMTRCMNYDPNQRP 280 >5UV4-A nrPDB Length = 311 Score = 99.7 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 78/212 (36%), Gaps = 20/212 (9%) Query: 23 AKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 IG+ G +KA G + +K + K REIK L ++H N+V L Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSK--KEFSREIKKLGSVRHPNLVPLR 87 Query: 83 EICRTKASPYNRCKGSIYLVFDF-----CEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGL 137 + + ++ D+ L+ L + + + + L Sbjct: 88 GYY------WGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCL 141 Query: 138 YYIHRNKIL-HRDMKAANVLI-TRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Y+H +++ H ++K++NVLI + D+ L R + ++ + Y Sbjct: 142 DYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALG---YS 198 Query: 196 PPELLLGERDY-GPPIDLWGAGCIMAEMWTRS 226 PPE + D++ G I+ E+ T Sbjct: 199 PPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >3REP-A nrPDB Length = 271 Score = 97.7 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 45/255 (17%), Positives = 100/255 (39%), Gaps = 31/255 (12%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 + + L K+ + GE++K R + G + +K + + + E L++ Sbjct: 8 DFKQLNFLTKLNENHSGELWKGRWQ--GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFS 65 Query: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT-----LSEIKRV 129 H NV+ ++ C++ +P+ L+ + + G L NVL + T S+ + Sbjct: 66 HPNVLPVLGACQSPPAPHPT------LITHWMPY---GSLYNVLHEGTNFVVDQSQAVKF 116 Query: 130 MQMLLNGLYYIHRNK-ILHR-DMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTN 187 + G+ ++H + ++ R + + +V+I D ++ S+A + Sbjct: 117 ALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARI---------SMADVKFSFQSPG 167 Query: 188 RVVTLWYRPPELLLGERDYG--PPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALI--SQ 243 R+ + PE L + + D+W ++ E+ TR + + Sbjct: 168 RMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEG 227 Query: 244 LCGSITPEVWPNVDN 258 L +I P + P+V Sbjct: 228 LRPTIPPGISPHVSK 242 >6EQI-C nrPDB Length = 433 Score = 96.6 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 56/362 (15%), Positives = 111/362 (30%), Gaps = 94/362 (25%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTG-----QKVALKKV---LMENEKE 57 ++VE + + + I +G V+ A+ + ++A+K + +E+ Sbjct: 4 ENVEQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNST 63 Query: 58 GFPITALRE---------------IKILQLLK-----HENVVNLIEICRTKASPYNRCKG 97 RE I+ + K H N+V + + + K Sbjct: 64 AILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQ 123 Query: 98 -------------------SIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 S++LV + L L + S + L + Sbjct: 124 LYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQL--LEAVA 181 Query: 139 YIHRNKILHRDMKAANVLITRDG-----VLKLADFG--LARAFSLAKNSQPNRYTNRVVT 191 +++ + I HRD+K+ N+L+ + + DFG L + + ++ Sbjct: 182 HMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGN 241 Query: 192 LWYRPPELLLGERD------YGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLC 245 PE+ + Y DLW G I E++ T + L Sbjct: 242 RALMAPEIANAKPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYDKT-------MKLLS 293 Query: 246 GSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID 305 S E P ++ D + +R+ L+ +L +R+D Sbjct: 294 KSYKEEDLP-------------------ELPDTIPFIIRN-----LVSNMLSRSTNKRLD 329 Query: 306 SD 307 D Sbjct: 330 CD 331 >6J6I-B nrPDB Length = 351 Score = 94.7 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 43/220 (19%), Positives = 80/220 (36%), Gaps = 23/220 (10%) Query: 43 QKVALKKVLMENE--KEGFPITALREIKILQLL-KHENVVNLIEICRTKASPYNRCKGSI 99 + +K+ + K +I + + H N + L+ C P Sbjct: 82 RSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFP-------- 133 Query: 100 YLVFDFCEHD----LAGLLSNVLVKF-TLSEIKRVMQMLLNGLYYIHR---NKILHRDMK 151 LVF+F EH G++ N S ++ + + N + Y+H I+HRD+K Sbjct: 134 VLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVK 193 Query: 152 AANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPID 211 +V + ++ KL+D L+ + SL + + T Y P L D Sbjct: 194 PMHVFLDKNWTAKLSD--LSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTD 250 Query: 212 LWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPE 251 ++ G + + T P + ++ L I L + Sbjct: 251 VYSFGICLLVIITGKPAIMTISDGD-LQGILSLVRELCEN 289 >4I94-A nrPDB Length = 300 Score = 88.9 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 94/282 (33%), Gaps = 55/282 (19%) Query: 32 EVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASP 91 V+K + + +++A+K+ ++ + L E K + L++ + NL+ C Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDS--RQFLEEAKAVGQLRNHRMANLLGCCYEDEER 100 Query: 92 YNRCKGSIYLVFDFCEHDL--AGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNK-ILHR 148 L+ +F ++ L + RV + L Y L+ Sbjct: 101 L--------LIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYH 152 Query: 149 DMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP 208 D+ A VL D +L+ FGL + K+ N L + PPE L R P Sbjct: 153 DLNAYRVLFDDDANPRLSCFGLMKNSRDGKSYSTN--------LAFTPPEYLRTGRV-TP 203 Query: 209 PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELV 268 ++ G ++ ++ + I H L LI Sbjct: 204 ESVIYSFGTLLLDLLSGKHIPPS----HALDLIRD------------------------- 234 Query: 269 KGQKRKVKDRLKAYVRDPYALDLID---KLLVLDPAQRIDSD 307 + + + L+ +LI + L +P +R + Sbjct: 235 RNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPK 276 >5UU1-A nrPDB Length = 324 Score = 88.5 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 47/189 (24%), Positives = 81/189 (42%), Gaps = 17/189 (8%) Query: 15 EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74 E +++ KIG G FG ++ A +K A V +E ++ G E+K Q + Sbjct: 14 EGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENG---PLFSELKFYQRVA 70 Query: 75 HENVVN---------LIEICRTKASPYNRCKGSIY--LVFDFCEHDLAGLLSNVLVKFTL 123 ++ + + I S KG Y +V + DL +S F Sbjct: 71 KKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQK-ISGQNGTFKK 129 Query: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDGVLKLADFGLARAFSLAKNSQ 181 S + ++ +L+ L YIH N+ +H D+KAAN+L+ + LAD+GL+ + N + Sbjct: 130 STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHK 189 Query: 182 PNRYTNRVV 190 + R Sbjct: 190 QYQENPRKG 198 >5C01-A nrPDB Length = 342 Score = 88.1 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 85/286 (29%), Gaps = 61/286 (21%) Query: 36 ARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRC 95 R R +V LK + + + ++ + H ++ + +C Sbjct: 101 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--- 155 Query: 96 KGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 +V ++ EH L L ++ V Q L + L Y+ ++H ++ N Sbjct: 156 -----MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRN 210 Query: 155 VLITRDGV-------LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG-ERDY 206 +L+ R G+ +KL+D G+ R+ + PE L G Sbjct: 211 ILLARLGLAEGTSPFIKLSDPGVG-----LGALSREERVERIP---WLAPECLPGGANSL 262 Query: 207 GPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL 265 +D WG G + E+ + +Q + + + P Sbjct: 263 STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP--------------- 307 Query: 266 ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 P L + L +P QR L Sbjct: 308 ------------------SCPQLATLTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 87.3 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 85/286 (29%), Gaps = 61/286 (21%) Query: 36 ARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRC 95 R R +V LK + + + ++ + H ++ + +C Sbjct: 78 GRDRGQELRVVLKVL--DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENI--- 132 Query: 96 KGSIYLVFDFCEHD-LAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN 154 +V ++ EH L L ++ V Q L + L Y+ ++H ++ N Sbjct: 133 -----MVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRN 187 Query: 155 VLITRDGV-------LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG-ERDY 206 +L+ R G+ +KL+D G+ R+ + PE L G Sbjct: 188 ILLARLGLAEGTSPFIKLSDPGVG-----LGALSREERVERIP---WLAPECLPGGANSL 239 Query: 207 GPPIDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL 265 +D WG G + E+ + +Q + + + P Sbjct: 240 STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP--------------- 284 Query: 266 ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALN 311 P L + L +P QR L Sbjct: 285 ------------------SCPQLATLTSQCLTYEPTQRPSFRTILR 312 >4IX6-A nrPDB Length = 350 Score = 86.2 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 63/333 (18%), Positives = 100/333 (30%), Gaps = 62/333 (18%) Query: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN----VV 79 +G G FG VF+ + Q V LK + + ++ H N Sbjct: 27 PLGSGNFGTVFRGVFKGD-QDVVLKNAKADVMAAEELLECEMDVNYHV---HANAKGTCA 82 Query: 80 NLIEICR----TKASPYNRCKGS-IYL---------VFDFCEHDLAGLLSNVLVKFTLSE 125 + YN ++L V A L+ + +E Sbjct: 83 RFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTA-PLATAMACADATE 141 Query: 126 I---KRVMQMLLNGLYYIHRNKILHRDMKAANVLITR--DGVLKLADFGLARAFSLAKNS 180 + K+ M+ LL L +H ++HRD+K AN++ GVLKL D G A + Sbjct: 142 LGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPET 201 Query: 181 QPNRYTNRVVTLWYR--------PPELLLGERDYGPPI---------DLWGAGCIMAEMW 223 + Y PP +D + D W AGC+M Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVM---- 257 Query: 224 TRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELY-EKLELVKGQKRKVKDRLKAY 282 QLA++ + + K + D Sbjct: 258 ------------LQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALD 305 Query: 283 VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 DL +L+ + R + AL+H FF Sbjct: 306 ANGGAGWDLCQRLMEAERDARASCEAALSHAFF 338 >5CLR-A nrPDB Length = 451 Score = 81.6 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 39/196 (19%), Positives = 72/196 (36%), Gaps = 27/196 (13%) Query: 34 FKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYN 93 FK G+ LK V ++ E E L L L+ + + + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAES---LTEFTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 94 RCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLS---EIKRVMQMLLNGLYYIHRNKILHRD 149 Y++ F + DL+ + + + L E+ +M + + + H ++HRD Sbjct: 148 ------YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRD 201 Query: 150 MKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGER--DYG 207 +K N+++ D L DFG + + K + T Y PEL E + Sbjct: 202 LKPGNIMLDADMQCHLVDFGSSSSDKEPKPA-------SWGTASYLAPELNAQEDFIAFS 254 Query: 208 PPIDLWGAGCIMAEMW 223 DL+ + E++ Sbjct: 255 QVSDLFALAYSLDELF 270 >2RSV-A nrPDB Length = 403 Score = 80.4 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 58/319 (18%), Positives = 115/319 (36%), Gaps = 33/319 (10%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKV------ALKKVLMEN 54 +A+Q+ E +++ IGQG FG ++ A + + V +K Sbjct: 26 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV----- 79 Query: 55 EKEGFPITALREIKILQLLKHE---------NVVNLIEICRTKASPYNRCKGSIY--LVF 103 + E+K Q + + + + S + G Y ++ Sbjct: 80 -EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIM 138 Query: 104 DFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDG 161 D DL + +F+ + ++ +L+ L YIH ++ +H D+KA+N+L+ Sbjct: 139 DRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD 198 Query: 162 VLKLADFGLARAFSLAKNSQPNRYTNRV---VTLWYRPPELLLGERDYGPPIDLWGAGCI 218 + L D+GLA + + + + T+ + + G DL G Sbjct: 199 QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYC 257 Query: 219 MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 M + T + N + + S++ E ++ + EK + + K + Sbjct: 258 MIQWLTGHLPWEDNLKDPKYVRDSKIRYR---ENIASLMDKCFPEKNKPGEIAKYMETVK 314 Query: 279 LKAYVRDPYALDLIDKLLV 297 L Y P +L D LL Sbjct: 315 LLDYTEKPLYENLRDILLQ 333 >2LAV-A nrPDB Length = 361 Score = 79.6 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 58/319 (18%), Positives = 115/319 (36%), Gaps = 33/319 (10%) Query: 1 MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKV------ALKKVLMEN 54 +A+Q+ E +++ IGQG FG ++ A + + V +K Sbjct: 19 LAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKV----- 72 Query: 55 EKEGFPITALREIKILQLLKHE---------NVVNLIEICRTKASPYNRCKGSIY--LVF 103 + E+K Q + + + + S + G Y ++ Sbjct: 73 -EPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIM 131 Query: 104 DFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT--RDG 161 D DL + +F+ + ++ +L+ L YIH ++ +H D+KA+N+L+ Sbjct: 132 DRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPD 191 Query: 162 VLKLADFGLARAFSLAKNSQPNRYTNRV---VTLWYRPPELLLGERDYGPPIDLWGAGCI 218 + L D+GLA + + + + T+ + + G DL G Sbjct: 192 QVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYC 250 Query: 219 MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDR 278 M + T + N + + S++ E ++ + EK + + K + Sbjct: 251 MIQWLTGHLPWEDNLKDPKYVRDSKIRYR---ENIASLMDKCFPEKNKPGEIAKYMETVK 307 Query: 279 LKAYVRDPYALDLIDKLLV 297 L Y P +L D LL Sbjct: 308 LLDYTEKPLYENLRDILLQ 326 >6G4J-A nrPDB Length = 315 Score = 69.2 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 77/229 (33%), Gaps = 26/229 (11%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Y ++G+G G V+ A + VALK ++ E+ +L+ Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFSKAQS 78 Query: 79 VNLIEICRTKASPY---NRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135 V + Y K S Y ++ + L L + I +M LL+ Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFY-AMEYIKGPL---LLKYVSDKGAEWIPVLMIQLLS 134 Query: 136 GLYYIHRNKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 L +H+ + D+K N+++T ++ D G K + + Y Sbjct: 135 SLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG-----GTTKEGRAIKEYTEFYDRGY 189 Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQ 243 G R P DL+ IM + + N + QL + + Sbjct: 190 ----WGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE 234 >4CI6-B nrPDB Length = 643 Score = 66.5 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 59/348 (16%), Positives = 110/348 (31%), Gaps = 59/348 (16%) Query: 39 RKTGQKVALKKVLMENEKEGFPITALREIKILQLL-----KHENVVNLIE-ICRTKASPY 92 + + VA + E+ E++ + + KH N+ N+ + Y Sbjct: 66 KDKQRLVA------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRY 119 Query: 93 NRCKGSIYLVFDFCEH-DLAGLLSNVLVKFT---------LSEIKRVMQMLLNGLYYIHR 142 L+ D + + L ++ + IK + LL+ ++ + Sbjct: 120 YYA-----LLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAK 174 Query: 143 NKILHRDMKAANVLITR-DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 I+H D+K NV+ R G + D GL QP +T ++ PEL + Sbjct: 175 AGIVHNDIKPGNVVFDRASGEPVVIDLGL----HSRSGEQPKGFTES-----FKAPELGV 225 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 G D++ + E+ +Q IT E +D Sbjct: 226 GNLGASEKSDVFLVVSTLLHGIEGF-------EKDPEIKPNQGLRFITSEPAHVMDENGY 278 Query: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDP-M 320 + G + I +L + R DS++A H+F Sbjct: 279 PIHRPGIAGVETAYTR-------------FITDILGVSADSRPDSNEARLHEFLSDGTID 325 Query: 321 PSDLKGMLSTHLT-SMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTE 367 K +L LT M RR ++ ++ R ++ T+ Sbjct: 326 EESAKQILKDTLTGEMSPLPTDVRRITPYYLRELSDLLRTHLSSAATK 373 >4O1O-A nrPDB Length = 717 Score = 63.1 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 28/131 (21%), Positives = 52/131 (39%), Gaps = 19/131 (14%) Query: 43 QKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVNLIEICRTKASPYNRCKGSIYL 101 Q+VA+K+ +E+ LQ + ++NVV +++ Sbjct: 370 QEVAVKRF------SEGSTRGQQEVSCLQSSRANDNVVTFYGS--------ESDGSCLHV 415 Query: 102 VFDFCEHDLAGLLSNVLVKFTLSE----IKRVMQMLLNGLYYIHRNKILHRDMKAANVLI 157 CE+ L L+N +E + ++ L + +HR+ H+D++ N+LI Sbjct: 416 CLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILI 475 Query: 158 TRDGVLKLADF 168 LADF Sbjct: 476 DSKNGTFLADF 486 Score = 32.3 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 28/94 (29%), Gaps = 25/94 (26%) Query: 272 KRKVKDRLKAYVRDPYALDLIDKLLVL--DPAQRIDSDDALNHDFFWSDPMPSDLKGMLS 329 K + + + D DLI L + R+ S L H FFWS Sbjct: 525 KNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWS------------ 570 Query: 330 THLTSMFEYLAPPRRKGSQITQQSTNQSRNPATT 363 R + +S ++RN + Sbjct: 571 ---------WESRYRTLRDVGNESDIKTRNQNSR 595 >4OAU-C nrPDB Length = 699 Score = 63.1 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 29/144 (20%), Positives = 56/144 (38%), Gaps = 22/144 (15%) Query: 31 GEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK-HENVVNLIEICRTKA 89 G ++ + K Q+VA+K + + A RE+ LQ + + ++V Sbjct: 357 GGIYLGFYEK--QEVAVKTFCEGSPR------AQREVSCLQSSRENSHLVTFYGS----- 403 Query: 90 SPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE----IKRVMQMLLNGLYYIH-RNK 144 +G +++ CE L L + +E + V+ + + +H Sbjct: 404 ---ESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 460 Query: 145 ILHRDMKAANVLITRDGVLKLADF 168 H+D++ N+LI LADF Sbjct: 461 YTHQDLQPQNILIDSKKAAHLADF 484 >5DMZ-A nrPDB Length = 365 Score = 59.6 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 85/245 (34%), Gaps = 41/245 (16%) Query: 9 ECPFCDEVSKYEKLAKI-------GQGTFGEVFKAR-----HRKTGQKVALKKVLMENEK 56 + P ++++ +K+ G+G F +V++A K QK LK N Sbjct: 50 KLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPW 109 Query: 57 EGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLA----G 112 E + T L E ++ ++H + + + LV + + Sbjct: 110 EFYIGTQLME-RLKPSMQHMF-MKFYSA--------HLFQNGSVLVGELYSYGTLLNAIN 159 Query: 113 LLSNVLVK-FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV--------- 162 L N K + +L + +H +I+H D+K N ++ + Sbjct: 160 LYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLS 219 Query: 163 --LKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMA 220 L L D G + + + +T + T ++ E+L + + ID +G + Sbjct: 220 AGLALIDLGQS--IDMKLFPKGTIFTAKCETSGFQCVEML-SNKPWNYQIDYFGVAATVY 276 Query: 221 EMWTR 225 M Sbjct: 277 CMLFG 281 >5GZA-A nrPDB Length = 290 Score = 59.2 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 40/225 (17%), Positives = 75/225 (33%), Gaps = 55/225 (24%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVV 79 ++ IGQG +V+ + + GQKVAL + + + F + +L+ L+ +VV Sbjct: 28 RRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADDFLHG----LSMLRALQSSHVV 81 Query: 80 NLIEICRTKASPYNRCKGSIYLVFDFCE----HDLAGLLSNVLVKF--TLSEIKRVMQML 133 L+ +C A V ++ L L+ ++ + ++ Sbjct: 82 TLVGVCEEDAVF----------VTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDY 131 Query: 134 LNGLYYIHRN--KI--------LHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 + L Y+H + I LH+ + + L+ D L LA + Sbjct: 132 VAFLAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKG 183 Query: 184 RYTNRVV----TLWYRPPELL-----------LGERDYGPPIDLW 213 + T + PE L Y D+W Sbjct: 184 GLGVKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6EAS-A nrPDB Length = 308 Score = 56.9 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 38/283 (13%), Positives = 86/283 (30%), Gaps = 50/283 (17%) Query: 34 FKARHRKTGQKVALKKVLMENEKEGFPI---TALREIKILQLLKHENVVNLIEICRTKAS 90 +K +G ++A+ L+ + K+ ++I L + H+N +NL+ C + Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHP 115 Query: 91 PYNRCKGSIYLVFDFCE-HDLAGLLS-NVLVKFTLSEIKRVMQMLLNGLYYIHRNKI--L 146 +VF++ L L K R+ + L ++H+ + Sbjct: 116 FTRV------MVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAA 169 Query: 147 HRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDY 206 R+ + V +T D K++D ++ AK + +++ Sbjct: 170 LRNFDSTTVYLTDDFAAKVSDL---EFWNDAKGHNSTTNNELAFSPDM--EDIVRK---- 220 Query: 207 GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLE 266 G ++ E+ T + E W + E Sbjct: 221 --------YGMVLLEILTGRVPSSEDDG--------------PLENWVSRYFEGGMRLEE 258 Query: 267 LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 L+ + + + + + DP +R + Sbjct: 259 LIDPSIGFFPEDTARALCEV-----VRSCIDRDPKKRPQMKEV 296 >5GZ9-A nrPDB Length = 305 Score = 56.5 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 80/218 (36%), Gaps = 44/218 (20%) Query: 22 LAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 L ++G+G VF + ++ KVAL ++ KE F +++L+ L+ E+VV L Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVALSRLTRLEMKEDFLHG----LQMLKSLQSEHVVTL 92 Query: 82 IEICRTKASPYNRCKGSIYLVFDFCE-HDLAGL-----LSNVLVKFTLSEIKRVMQMLLN 135 + C + ++ ++ L+ L LS T ++ ++ Sbjct: 93 VGYCEEDGT----------ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVS 142 Query: 136 GLYYIHRNKILHR------DMKAANV---LITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 + Y+H + + R D+ + L+T + + D A + + Sbjct: 143 IINYLHHSPLGTRVMCDSNDL-PKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCG 200 Query: 187 NRVVTLWYRPPELLLGE-----------RDYGPPIDLW 213 +R + + PE L Y +D+W Sbjct: 201 HRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >4AZW-A nrPDB Length = 471 Score = 55.8 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 46/136 (33%), Gaps = 18/136 (13%) Query: 42 GQKVALKK--------VLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYN 93 G+ K +L E + EIK L + Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQ-------PPAGFDAPAVLAHG 311 Query: 94 RCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAA 153 S +LV + L LS++L + ++++ LL L + + H D++ Sbjct: 312 ENAQSGWLVMEKLPGRL---LSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPW 368 Query: 154 NVLITRDGVLKLADFG 169 NV++ +L DFG Sbjct: 369 NVMVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 55.4 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 46/136 (33%), Gaps = 18/136 (13%) Query: 42 GQKVALKK--------VLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYN 93 G+ K +L E + EIK L + Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQ-------PPAGFDAPAVLAHG 311 Query: 94 RCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAA 153 S +LV + L LS++L + ++++ LL L + + H D++ Sbjct: 312 ENAQSGWLVMEKLPGRL---LSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPW 368 Query: 154 NVLITRDGVLKLADFG 169 NV++ +L DFG Sbjct: 369 NVMVDARQHARLIDFG 384 >6EWX-A nrPDB Length = 484 Score = 54.2 bits (129), Expect = 8e-08, Method: Composition-based stats. Identities = 29/228 (12%), Positives = 62/228 (27%), Gaps = 78/228 (34%) Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--------------------- 161 + ++ L NGL ++ + I+HRD+ N+L+ Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 162 --------------------VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 L +++F A+ + + + PE++ Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR-----LAPEIVS 323 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 + D + G ++ E+ + E+ Sbjct: 324 ASQY--RKFDEFQTGILIYELLHQPNPF------------------------------EV 351 Query: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 +L ++ + + P L LL DP +RI +A Sbjct: 352 RAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEA 399 >4CYJ-A nrPDB Length = 438 Score = 53.4 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 66/152 (43%), Gaps = 32/152 (21%) Query: 33 VFKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL------QLLKHENVVNLIEICR 86 V+KA++ + G+ AL+++ EG+ +T E IL + +K+ ++V + E+ Sbjct: 71 VYKAQNSRNGRHYALRRL------EGYRLT--NEKAILNVMKDWKKIKNASIVTIHEVFT 122 Query: 87 TKASPYNRCKGSIYLVFDFCEHDLAGLLSNV------------LVKFTLSEIKRVMQMLL 134 T+ G L+F + H L+ L + I + + Sbjct: 123 TRE------FGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIA 176 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLA 166 N L IH N++ R ++ + +++T ++L+ Sbjct: 177 NALKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >6G38-A nrPDB Length = 357 Score = 51.9 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 39/189 (20%), Positives = 64/189 (33%), Gaps = 45/189 (23%) Query: 7 SVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEK------EGFP 60 V C K ++ KIG+G FGEVF+ T VA+K + +E + Sbjct: 31 PVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTF 88 Query: 61 ITALREIKILQLL-----------------KHENVVN------LIEICRT--------KA 89 L EI I + L + V L++ Sbjct: 89 EEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSAND 148 Query: 90 SPYNRCKGSIYLVFDFCEHDLAGL-LSNVLVKFT-LSEIKRVMQMLLNGLYYIH-RNKIL 146 P +++V +F + G+ L + K + L+ K ++ L L + Sbjct: 149 RPDFFKDDQLFIVLEF---EFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFE 205 Query: 147 HRDMKAANV 155 HRD+ NV Sbjct: 206 HRDLHWGNV 214 >2JII-A nrPDB Length = 352 Score = 51.5 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 38/215 (17%), Positives = 70/215 (32%), Gaps = 17/215 (7%) Query: 100 YLVFDFCEHDLAGLLS-NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT 158 +LV L L + + + +V LL+ L ++H N+ +H ++ A N+ + Sbjct: 134 FLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 159 --RDGVLKLADFGLARAFSLAKNSQPNRYTNRV---VTLWYRPPELLLGERDYGPPIDLW 213 + LA +G A + + +R L + +L G DL Sbjct: 194 PEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP-SRRSDLQ 252 Query: 214 GAGCIMAEMWTRSPIMQG--NTEQHQLALISQLCGSITPEVWPN----VDNYELYEKLEL 267 G M + + + + P V P + L + L++ Sbjct: 253 SLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKV 312 Query: 268 VKGQKRKVKDRLKAYVRDPYALDLIDKLLV--LDP 300 V + K + A L+ L V DP Sbjct: 313 VMALTYEEKPPYAMLRNNLEA--LLQDLRVSPYDP 345 >4WWA-A nrPDB Length = 261 Score = 51.5 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 43/204 (21%), Positives = 76/204 (37%), Gaps = 36/204 (17%) Query: 11 PFCDEVSKYEK----LAKIGQGTFGEV-------FKARHRKTGQKVALK-----KVLMEN 54 F D+VS Y +A I QG V + R + + QK +K + Sbjct: 4 EFIDKVSSYLTPDVDIAPISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQ 63 Query: 55 EKEGFPI-TALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL-AG 112 + L E ++L L + +C + + G I+L +F DL G Sbjct: 64 IDQALTKHRTLNESRLLAKL-----YLIPGLCVPQLIACDPYNGFIWL--EFLGEDLPGG 116 Query: 113 LLSNVLVKFTLSE--------IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG--- 161 + L F + ++ + + +H N H D+ ++N+++ RDG Sbjct: 117 HGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARW 176 Query: 162 VLKLADFGLARAFSLAKNSQPNRY 185 L DFGL +L ++ + Y Sbjct: 177 TPHLIDFGLGSVSNLVEDKGVDLY 200 >6M7Z-A nrPDB Length = 319 Score = 51.1 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 26/226 (11%), Positives = 60/226 (26%), Gaps = 60/226 (26%) Query: 100 YLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR 159 Y+ + + +L + +++ + ++ L +H +LHR ++ + + Sbjct: 123 YIFHPLSKGLVGDMLET---GRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLP 179 Query: 160 DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL--------LLGERDYGPPID 211 DG + L A + PE+ L + + D Sbjct: 180 DGTVVLGGLDTAAPIGTETRLWVGFFGQET------APEIDRNFLADLALTQGRHTVKSD 233 Query: 212 LWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQ 271 ++ G ++L+ Sbjct: 234 VYSLGV------------------------------------------AFRNLVQLLGNG 251 Query: 272 KRKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRIDSDDALNHDFFW 316 +DR LD L K++ +P R ++ + F Sbjct: 252 NLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFE 297 >3ENH-A nrPDB Length = 540 Score = 48.8 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 63/165 (38%), Gaps = 26/165 (15%) Query: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF------PITALREIKILQLLKHENV 78 IG+G ++ R V +K+ + + ++ RE + L L+K Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVK---- 397 Query: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138 + ++ + ++ + LA + + + + + + Sbjct: 398 ----DFGIPAPYIFDVDLDNKRIMMSYINGKLAKDV--------IEDNLDIAYKIGEIVG 445 Query: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPN 183 +H+N ++H D+ +N + +D L + DFGL + +L ++ + Sbjct: 446 KLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVD 488 >6BHC-A nrPDB Length = 438 Score = 48.0 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 70/228 (30%), Gaps = 59/228 (25%) Query: 102 VFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDG 161 V DF LA + ++ ++ L +GL ++ + H D++ N+L+ Sbjct: 158 VADFVRDSLAQHGKS--PDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQ 215 Query: 162 VLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY--------------------RPPELLL 201 G A+ F A+ + + Y R++ + PE++ Sbjct: 216 PG-----GTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIIT 270 Query: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 + D + G ++ EM + D Sbjct: 271 ATQY--KKCDEFQTGILIYEML---------------------------HLPNPFDENPE 301 Query: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 ++ E + ++ R L LL +P++RI DA Sbjct: 302 LKEREYTRADLPRIPFRSPY---SRGLQQLASCLLNPNPSERILISDA 346 >5VE6-A nrPDB Length = 492 Score = 48.0 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 20/35 (57%) Query: 123 LSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI 157 + ++ L NGL ++ + I+HRD+ N+L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 33.8 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 16/115 (13%), Positives = 32/115 (27%), Gaps = 32/115 (27%) Query: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 PE++ + D + G ++ E+ + Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF------------------------- 357 Query: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 E+ +L ++ + + P L LL DP +RI +A Sbjct: 358 -----EVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEA 407 >4BWP-A nrPDB Length = 448 Score = 46.9 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 50/143 (34%), Gaps = 38/143 (26%) Query: 34 FKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYN 93 ++A H TG K L+++ + +T +++ + L+H NVV L E+ TKA Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTL---VEMWKKLQHTNVVQLREVFTTKA---- 119 Query: 94 RCKGSIYLVFDFCEHD---LAGLLSNVLVK----------------------------FT 122 S+ LV+D+ LA + Sbjct: 120 FGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLP 179 Query: 123 LSEIKRVMQMLLNGLYYIHRNKI 145 + I ++ L GL IH + Sbjct: 180 EATIWSIIMQLTAGLKAIHHAGL 202 >3Q60-A nrPDB Length = 371 Score = 46.1 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 52/326 (15%), Positives = 94/326 (28%), Gaps = 56/326 (17%) Query: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREI-----KILQL 72 K + + + G VF R + + ALK M E + L E ++L Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLGE 122 Query: 73 L-----KHENVVNLIEICRTKASPYNRCKGS---------IYLVFDFCEHDLAGLLS--N 116 ++ + ++ P L+ DL L S + Sbjct: 123 SPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLELLFSTLD 182 Query: 117 VLVKFTLSE---IKRVM-QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLAR 172 + F E ++ L+ + ++H N+ I DG L L D Sbjct: 183 FVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD----- 237 Query: 173 AFSLAKNSQPNRYTNRVVTLWYRPPELLLGER-DYGPPIDLWGAGCIMAEMWTRSPIMQG 231 +L K ++ VT Y P E L + ++ W G + +W Sbjct: 238 VSALWKVGTRGPASSVPVT--YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF-- 293 Query: 232 NTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 G +TP + + K ++ + L Sbjct: 294 --------------GLVTPGIKGSW-------KRPSLRVPGTDSLAFGSCTPLPDFVKTL 332 Query: 292 IDKLLVLDPAQRIDSDDALNHDFFWS 317 I + L D +R+ +A+ F Sbjct: 333 IGRFLNFDRRRRLLPLEAMETPEFLQ 358 >2W1Z-A nrPDB Length = 368 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 41/130 (31%), Gaps = 7/130 (5%) Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ L+ + ++H D + N+L+ + G + L F S + Sbjct: 194 LQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGF---EHLVRDGASAVSPIG 250 Query: 187 NRVVTLWYRPPELLLGERDY----GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 +L + + P D W G + +W + E + I Sbjct: 251 RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIY 310 Query: 243 QLCGSITPEV 252 + C +I V Sbjct: 311 RRCKNIPQPV 320 >3BYV-A nrPDB Length = 377 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 25/172 (14%), Positives = 61/172 (35%), Gaps = 11/172 (6%) Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF------GLARAFSLAKNS 180 ++ ++ L +H ++H ++ ++++ + G + L F G S+++ Sbjct: 209 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGARVVSSVSRGF 268 Query: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 +P R T+ Y D W G ++ +W + + Sbjct: 269 EPPELEARRATISY----HRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEW 324 Query: 241 ISQLCGSITPEVWPNVDNY-ELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 I + C +I V ++ + ++ L+ Q + + + AL L Sbjct: 325 IFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAALPL 376 >4CZY-B nrPDB Length = 429 Score = 42.7 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 70/172 (40%), Gaps = 37/172 (21%) Query: 34 FKARHRKTGQKVALKKVLMENEKEGFPITALREIKIL------QLLKHENVVNLIEICRT 87 +KA++ K G+ AL+++ EG+ +T E IL + + + N+V + E T Sbjct: 61 YKAQNNKNGRHFALRRI------EGYRLT--NEKAILNVTKEWKKIINANIVTVHEAFTT 112 Query: 88 KASPYNRCKGSIYLVFDFCEHDLAGLLSNV-------------LVKFTLSEIKRVMQMLL 134 + S+ V+DF H L+ L + K + + + + Sbjct: 113 E----FFGDSSLIFVYDF--HPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIA 166 Query: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 N L IH K+ R ++ + + I + ++LA + + PNR T Sbjct: 167 NALLAIHNAKLAARCLELSKI-IWENNRIRLA---ACSILDVLHHDSPNRKT 214 >3DZO-A nrPDB Length = 413 Score = 41.9 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 21/170 (12%), Positives = 54/170 (31%), Gaps = 8/170 (4%) Query: 127 KRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYT 186 ++ ++ L +H ++H ++ ++++ + G + L F S + Sbjct: 214 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGASAVSPIG 270 Query: 187 NRVVTLWYRPPELLLGERDY----GPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALIS 242 +L + + D W G + +W + I Sbjct: 271 RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIF 330 Query: 243 QLCGSITPEVWPNVDNY-ELYEKLELVKGQKRKVKDRLKAYVRDPYALDL 291 + C +I V ++ + ++ L+ Q + + + AL L Sbjct: 331 RSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAALPL 380 >1TQM-A nrPDB Length = 282 Score = 36.5 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 31/163 (19%), Positives = 57/163 (34%), Gaps = 35/163 (21%) Query: 21 KLAKIGQGTFGEVFKARHRKTGQKVAL---------KKVLMENEKEGFPITAL------R 65 +G+G VF K G+ V KKV + + + L Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 66 EIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE 125 E + LQ L+ A P ++ + + A L V V+ Sbjct: 154 EFRALQKLQG------------LAVPKVYAWEGNAVLMELID---AKELYRVRVENPDEV 198 Query: 126 IKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 168 + +++ + + H I+H D+ NVL++ +G + + DF Sbjct: 199 LDMILEEVAK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >5YK0-A nrPDB Length = 452 Score = 36.1 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 54/170 (31%), Gaps = 35/170 (20%) Query: 31 GEVFKARHRKTGQKVALKKVLM--ENEKEGFPITALREIKILQLLK-HENVVNLIEICRT 87 G+V KA G++VA+K + T R + +L+ L +V +++ Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 88 KAS---------------------------PYNRCKGSIYLVFDFCEHDLAGLLSNVLVK 120 + P+ ++ ++ E + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 121 FTLSEIKRVMQML-LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFG 169 I ++ L + + ++H D N ++ DG + + DFG Sbjct: 265 EQRDLIGTLLAELTFDAPRRL---GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6G18-v nrPDB Length = 552 Score = 35.0 bits (79), Expect = 0.058, Method: Composition-based stats. Identities = 13/109 (11%), Positives = 39/109 (35%), Gaps = 16/109 (14%) Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 ++A++E ++ L R P +V + + +V Sbjct: 155 RLSAMKEFAYMKAL----------YERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVED 204 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 168 ++ + M++++ + + ++H D N+++ + + DF Sbjct: 205 PASVYD--EAMELIVK----LANHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 34.2 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 13/109 (11%), Positives = 39/109 (35%), Gaps = 16/109 (14%) Query: 60 PITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV 119 ++A++E ++ L R P +V + + +V Sbjct: 155 RLSAMKEFAYMKAL----------YERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVED 204 Query: 120 KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADF 168 ++ + M++++ + + ++H D N+++ + + DF Sbjct: 205 PASVYD--EAMELIVK----LANHGLIHGDFNEFNLILDESDHITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 32.3 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 20/149 (13%) Query: 21 KLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80 IGQG+ E+F+ + + K L+ N+ A +E ++ Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALYK--KYDLIGNQYNEILEMAWQESEL----------- 90 Query: 81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYI 140 +AS + G +YL + + + + +Q++ + Sbjct: 91 FNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESL--YLQLICK----L 144 Query: 141 HRNKILHRDMKAANVLITRDGV-LKLADF 168 + I+H D+ N+L ++ L DF Sbjct: 145 NELSIIHYDLNTGNMLYDKESESLFPIDF 173 >3FHN-A nrPDB Length = 706 Score = 32.3 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 37/102 (36%), Gaps = 13/102 (12%) Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL------AGLLSNVLVKFTLSEIK 127 +N V LI P+ + + + L + L +L +L+E + Sbjct: 394 SSQNFVKLINKIYDYLEPFYDLDFDLLVRYKLMTCSLIFMNLTSSYLDYILTVDSLNETR 453 Query: 128 RVMQMLLNGLYYIHRNKILHRDMK--AANVLITRDGVLKLAD 167 Q L + + ++R +K ++N + ++L D Sbjct: 454 TKEQELYQTMAKLQHVNFVYRKIKSLSSNFIF-----IQLTD 490 >4BFR-A nrPDB Length = 952 Score = 31.9 bits (71), Expect = 0.51, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 25/63 (39%), Gaps = 10/63 (15%) Query: 107 EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLA 166 E++ L + +FTLS + + G+ H N+++ + G L Sbjct: 769 EYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHS----------DNIMVKKTGQLFHI 818 Query: 167 DFG 169 DFG Sbjct: 819 DFG 821 >5CJH-A nrPDB Length = 764 Score = 30.7 bits (68), Expect = 0.94, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 62/198 (31%), Gaps = 26/198 (13%) Query: 141 HRNKILHRDMKAANVLITRDGVLKLADFG---LARAFSLAKNSQPNRYTNRVVTLWYRPP 197 H H +K +N+ + AD G L S+ + PN+ T+ + +W + P Sbjct: 292 HAFGKTHGAVKGSNI----GPAPEAADLGMQGLGWHNSVGDGNGPNQMTSGLEVIWTKTP 347 Query: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 W G + + + +++ HQ ++ P Sbjct: 348 ---------TK----WSNGYLESLINNNWTLVESPAGAHQWEAVNGTVDYPDPFDKTKFR 394 Query: 258 NYE-LYEKLELVKGQKRKVKDRLKAYVRDPYALDLID---KLLVLD--PAQRIDSDDALN 311 L L L+ + + + A KLL D P R + Sbjct: 395 KATMLTSDLALINDPEYLKISQRWLEHPEELADAFAKAWFKLLHRDLGPTTRYLGPEVPK 454 Query: 312 HDFFWSDPMPSDLKGMLS 329 F W DP+P+ ++ Sbjct: 455 ESFIWQDPLPAREGDLID 472 >6EF6-A nrPDB Length = 354 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 15/28 (53%), Gaps = 3/28 (10%) Query: 144 KILHRDMKAANVLITRD---GVLKLADF 168 ++H D++ AN+L+ + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6DFL-A nrPDB Length = 259 Score = 29.6 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 56/149 (37%), Gaps = 11/149 (7%) Query: 26 GQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEIC 85 G+G F ++ + G+ K +L + A +E + ++ L HE V + Sbjct: 45 GRGYFVKIHRGI--GWGEI--AKNLLTAKLP---VLGARQEWQAIRRL-HEAGVATMTAV 96 Query: 86 RTKASPYNRCKGSIYLVFDFCEH--DLAGLLSNVLVKFTLSEIKRVMQM-LLNGLYYIHR 142 + + ++V + DL + + +KR + + + +HR Sbjct: 97 AYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHR 156 Query: 143 NKILHRDMKAANVLITRDGVLKLADFGLA 171 + HRD + L+ D + DF L+ Sbjct: 157 AGVNHRDCYICHFLLHTDKPVSADDFRLS 185 >6FAI-l nrPDB Length = 425 Score = 29.2 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 24/177 (13%), Positives = 52/177 (29%), Gaps = 44/177 (24%) Query: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALK---------------KVLMENEKEGFPITA 63 Y IG G +++K + +V +K + ++ +G Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 64 L------REIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNV 117 L +E + + +L + P +V + E L Sbjct: 154 LSRLAANKEYQFMSML----------YSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKH 203 Query: 118 LVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR------DGVLKLADF 168 I ++ L+ + + + ++H D N++I D + DF Sbjct: 204 ------KNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >4AJW-A nrPDB Length = 934 Score = 28.8 bits (63), Expect = 3.6, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 22/63 (34%), Gaps = 10/63 (15%) Query: 107 EHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLA 166 + L + +FTLS + + G+ H N++I G L Sbjct: 751 SKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS----------DNIMIRESGQLFHI 800 Query: 167 DFG 169 DFG Sbjct: 801 DFG 803 >3L82-B nrPDB Length = 227 Score = 28.8 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 14/37 (37%), Gaps = 1/37 (2%) Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 LNH + D L G L + + E + R + Sbjct: 192 LLNHPWLVQDTEAETLTGFL-NGIEWILEEVESKRAR 227 >4EJ0-A nrPDB Length = 342 Score = 28.8 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 17/33 (51%) Query: 6 DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARH 38 + V+C D + K E + + +G FG+V H Sbjct: 54 NLVDCEIDDYLDKTEFVERFARGDFGKVRAVFH 86 >5FBM-A nrPDB Length = 99 Score = 28.8 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 13/34 (38%), Positives = 20/34 (58%), Gaps = 6/34 (17%) Query: 20 EKLAKIGQGTFGEVF-----KARHRKTGQKVALK 48 EK+ IG G F EV K R+ +TG+++ +K Sbjct: 41 EKVQLIGFGNF-EVRERAARKGRNPQTGEEIKIK 73 >3L2O-B nrPDB Length = 312 Score = 28.8 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 14/37 (37%), Gaps = 1/37 (2%) Query: 309 ALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRK 345 LNH + D L G L + + E + R + Sbjct: 277 LLNHPWLVQDTEAETLTGFL-NGIEWILEEVESKRAR 312 >3CDI-A nrPDB Length = 723 Score = 28.8 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 22/54 (40%), Gaps = 8/54 (14%) Query: 20 EKLAKIGQGTFGEVFKARHRKTGQKV------ALKKVLMENEKEGFPITALREI 67 + IG+G G V +A +TG + +K + EK I + EI Sbjct: 570 KIKDVIGKG--GSVIRALTEETGTTIEIEDDGTVKIAATDGEKAKHAIRRIEEI 621 >5LJ3-H nrPDB Length = 591 Score = 28.4 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 17/28 (60%), Gaps = 1/28 (3%) Query: 147 HRDMKAANVLITRDGVLK-LADFGLARA 173 HRD+ N+LI RD + K + DF L + Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQ 68 >3QLB-A nrPDB Length = 748 Score = 28.0 bits (61), Expect = 6.0, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 18/35 (51%) Query: 159 RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 R G++ LAD GLA S + + P TN T + Sbjct: 510 RTGLVYLADNGLAPYISYSTSFDPVLGTNFYGTPY 544 >1Z82-A nrPDB Length = 335 Score = 27.6 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 38/95 (40%), Gaps = 10/95 (10%) Query: 24 KIGQGTFGEVFKARHRKTGQKV---ALKKVLMENEKEGFPITALREIKI-------LQLL 73 +G G++G VF + G++V A +K +++ + E KI L+ + Sbjct: 19 VLGAGSWGTVFAQMLHENGEEVILWARRKEIVDLINVSHTSPYVEESKITVRATNDLEEI 78 Query: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH 108 K E+++ + + R +V + + Sbjct: 79 KKEDILVIAIPVQYIREHLLRLPVKPSMVLNLSKG 113 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.142 0.430 Lambda K H 0.267 0.0435 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,395,438 Number of Sequences: 36641 Number of extensions: 648076 Number of successful extensions: 5920 Number of sequences better than 10.0: 512 Number of HSP's better than 10.0 without gapping: 925 Number of HSP's successfully gapped in prelim test: 54 Number of HSP's that attempted gapping in prelim test: 1873 Number of HSP's gapped (non-prelim): 1314 length of query: 372 length of database: 10,336,785 effective HSP length: 99 effective length of query: 273 effective length of database: 6,709,326 effective search space: 1831645998 effective search space used: 1831645998 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.6 bits)