BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P50613 (346 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1UA2-A nrPDB 716 0.0 2BPM-A nrPDB 277 5e-75 3NIZ-A nrPDB 272 2e-73 4AU8-A nrPDB 265 2e-71 6GU6-A nrPDB 256 8e-69 1V0B-A nrPDB 241 2e-64 3GC0-A nrPDB 241 2e-64 4KRC-A nrPDB 236 1e-62 5G6V-A nrPDB 228 2e-60 3MIA-A nrPDB 213 1e-55 5EFQ-A nrPDB 208 3e-54 4AGU-A nrPDB 206 1e-53 4NST-A nrPDB 204 6e-53 4BGQ-A nrPDB 196 2e-50 1G3N-A nrPDB 195 2e-50 4BBM-A nrPDB 193 9e-50 2W96-B nrPDB 189 1e-48 5NGU-A nrPDB 188 3e-48 3ZDU-A nrPDB 187 4e-48 4QTB-A nrPDB 186 2e-47 3OZ6-A nrPDB 184 5e-47 4ZSG-A nrPDB 184 7e-47 4IC8-A nrPDB 183 8e-47 3GC9-A nrPDB 183 1e-46 5Z33-A nrPDB 181 4e-46 2F9G-A nrPDB 179 1e-45 5AIR-A nrPDB 179 2e-45 6DTL-A nrPDB 178 3e-45 4CRL-A nrPDB 176 1e-44 4EWQ-A nrPDB 174 5e-44 4QNY-A nrPDB 171 6e-43 3OHT-A nrPDB 170 7e-43 4MYG-A nrPDB 170 8e-43 4E7W-A nrPDB 170 1e-42 3PG1-A nrPDB 167 6e-42 1CM8-A nrPDB 162 2e-40 2I6L-A nrPDB 160 6e-40 4O2Z-A nrPDB 155 3e-38 3N9X-A nrPDB 154 5e-38 5ZTN-A nrPDB 153 9e-38 3RP9-A nrPDB 151 4e-37 3NIE-A nrPDB 150 8e-37 3E3P-A nrPDB 145 3e-35 5AWM-A nrPDB 145 4e-35 3E7O-A nrPDB 144 7e-35 1JNK-A nrPDB 142 3e-34 2XS0-A nrPDB 141 4e-34 3FI2-A nrPDB 141 4e-34 5Y86-A nrPDB 140 9e-34 6O6Q-A nrPDB 132 3e-31 3EB0-A nrPDB 131 3e-31 3NCG-A nrPDB 130 9e-31 3DFA-A nrPDB 127 8e-30 5XVU-A nrPDB 125 2e-29 4LFI-A nrPDB 122 2e-28 6HMD-A nrPDB 119 2e-27 6EII-A nrPDB 117 7e-27 4MD7-E nrPDB 117 7e-27 3LIJ-A nrPDB 114 5e-26 3MN3-A nrPDB 113 1e-25 2PVN-A nrPDB 113 1e-25 4MVF-A nrPDB 113 1e-25 2WQN-A nrPDB 110 6e-25 4IAN-A nrPDB 109 2e-24 3DXN-A nrPDB 109 2e-24 3MA6-A nrPDB 108 3e-24 5JN2-A nrPDB 108 4e-24 4RGJ-A nrPDB 107 5e-24 2J90-A nrPDB 107 7e-24 3HZT-A nrPDB 107 8e-24 2UV2-A nrPDB 107 1e-23 2Y7J-A nrPDB 106 1e-23 4JXF-A nrPDB 105 2e-23 1U5R-A nrPDB 105 2e-23 3Q5I-A nrPDB 105 3e-23 2GCD-A nrPDB 105 4e-23 4I6B-A nrPDB 104 6e-23 3COM-A nrPDB 104 6e-23 4B6L-A nrPDB 103 8e-23 3H4J-B nrPDB 103 8e-23 3Q53-A nrPDB 103 9e-23 4CZT-A nrPDB 102 2e-22 4APC-A nrPDB 102 2e-22 6FD3-A nrPDB 102 2e-22 1S9I-A nrPDB 102 3e-22 4UZD-A nrPDB 102 4e-22 4D28-A nrPDB 101 4e-22 2WO6-A nrPDB 101 6e-22 5KKR-C nrPDB 100 1e-21 4FG9-A nrPDB 100 1e-21 3D2K-A nrPDB 100 1e-21 6FYV-A nrPDB 100 1e-21 3TAC-A nrPDB 100 2e-21 3EQC-A nrPDB 100 2e-21 4LG4-A nrPDB 99 2e-21 5X8I-B nrPDB 99 2e-21 4AN9-A nrPDB 99 3e-21 2YCR-A nrPDB 99 3e-21 6AO5-A nrPDB 99 3e-21 1KOA-A nrPDB 99 4e-21 3UTO-A nrPDB 98 5e-21 2X4F-A nrPDB 98 6e-21 4YNZ-A nrPDB 97 7e-21 3GUB-A nrPDB 97 8e-21 2V7O-A nrPDB 97 9e-21 3I6U-A nrPDB 97 1e-20 2XNP-A nrPDB 97 1e-20 2VN9-A nrPDB 97 1e-20 5DBX-A nrPDB 96 2e-20 6FDY-U nrPDB 96 2e-20 6E2O-A nrPDB 96 2e-20 5DYK-A nrPDB 96 2e-20 2JDO-A nrPDB 96 2e-20 6CMJ-A nrPDB 96 3e-20 4YZB-A nrPDB 96 3e-20 5D9K-A nrPDB 96 3e-20 3DB8-A nrPDB 95 4e-20 4EQM-A nrPDB 95 4e-20 2YAB-A nrPDB 95 5e-20 2JD5-A nrPDB 95 6e-20 6HXF-B nrPDB 94 7e-20 5KZ7-A nrPDB 94 8e-20 2VZ6-A nrPDB 94 8e-20 1KOB-A nrPDB 94 8e-20 2HAK-A nrPDB 94 8e-20 3A8W-A nrPDB 94 8e-20 5J5T-A nrPDB 94 9e-20 5WAX-A nrPDB 94 1e-19 5U6Y-A nrPDB 93 1e-19 5YKS-A nrPDB 93 1e-19 4FR4-A nrPDB 93 1e-19 5F9E-A nrPDB 93 2e-19 5IG1-A nrPDB 93 2e-19 6C9D-A nrPDB 93 2e-19 3DAK-A nrPDB 93 2e-19 1PHK-A nrPDB 93 2e-19 4B8L-A nrPDB 93 2e-19 5FG8-A nrPDB 92 2e-19 2W4O-A nrPDB 92 4e-19 4RLP-A nrPDB 92 4e-19 5FET-A nrPDB 92 4e-19 3F3Z-A nrPDB 92 4e-19 4M7I-A nrPDB 92 4e-19 4L42-A nrPDB 92 4e-19 4REW-A nrPDB 92 5e-19 2A27-A nrPDB 91 5e-19 1ZWS-A nrPDB 91 6e-19 4RED-A nrPDB 91 6e-19 5ES1-A nrPDB 91 6e-19 2QNJ-A nrPDB 91 7e-19 4CFH-A nrPDB 91 8e-19 2WTK-C nrPDB 91 8e-19 2BRG-A nrPDB 90 1e-18 6QAU-A nrPDB 90 1e-18 3SOA-A nrPDB 90 1e-18 5XZW-A nrPDB 90 2e-18 2Z7Q-A nrPDB 90 2e-18 3UDB-A nrPDB 89 2e-18 3KK8-A nrPDB 89 3e-18 5UUU-A nrPDB 89 3e-18 2BDW-A nrPDB 89 4e-18 5O0Y-A nrPDB 89 4e-18 4AF3-A nrPDB 89 4e-18 3PVW-A nrPDB 88 4e-18 2F57-A nrPDB 88 5e-18 5YV8-A nrPDB 88 6e-18 4NIF-A nrPDB 87 7e-18 2XIK-A nrPDB 87 7e-18 3MV5-A nrPDB 87 8e-18 3ORZ-A nrPDB 87 1e-17 4PDS-A nrPDB 87 1e-17 4CQG-A nrPDB 87 1e-17 2OU7-A nrPDB 87 1e-17 6CQF-A nrPDB 87 2e-17 3ZUT-A nrPDB 86 2e-17 4CSV-A nrPDB 86 2e-17 4J52-A nrPDB 86 3e-17 5HVK-A nrPDB 86 3e-17 5JZN-A nrPDB 85 4e-17 1FOT-A nrPDB 85 4e-17 3BHH-A nrPDB 85 4e-17 2JC6-A nrPDB 85 5e-17 4FIE-A nrPDB 85 5e-17 5B2L-A nrPDB 85 6e-17 3C51-A nrPDB 85 6e-17 2Q0N-A nrPDB 84 6e-17 3KN6-A nrPDB 84 7e-17 4JDH-A nrPDB 84 7e-17 5KCV-A nrPDB 84 8e-17 4XBR-A nrPDB 84 9e-17 4WNO-A nrPDB 84 1e-16 3HDN-A nrPDB 84 1e-16 5UNP-A nrPDB 84 1e-16 4JG6-A nrPDB 84 1e-16 3HKO-A nrPDB 84 1e-16 1ZXE-A nrPDB 84 1e-16 3ALO-A nrPDB 83 1e-16 4CFF-A nrPDB 83 2e-16 4C59-A nrPDB 82 3e-16 6CCF-A nrPDB 82 3e-16 3QGY-A nrPDB 82 3e-16 3UC3-A nrPDB 82 3e-16 5EZV-A nrPDB 82 3e-16 4E93-A nrPDB 82 4e-16 4WB7-A nrPDB 82 4e-16 6DBN-A nrPDB 82 4e-16 2YZA-A nrPDB 82 4e-16 4QMW-A nrPDB 82 5e-16 6J5U-C nrPDB 82 5e-16 5N23-A nrPDB 82 5e-16 2A1A-B nrPDB 81 5e-16 1FVR-A nrPDB 81 5e-16 6E9W-A nrPDB 81 6e-16 2JAM-A nrPDB 81 6e-16 2R2P-A nrPDB 81 6e-16 3TXO-A nrPDB 81 7e-16 3ORP-A nrPDB 81 7e-16 4KS7-A nrPDB 81 7e-16 4CRS-A nrPDB 81 7e-16 5D7A-A nrPDB 81 8e-16 4E20-A nrPDB 80 1e-15 3IS5-A nrPDB 80 1e-15 5LOH-A nrPDB 80 1e-15 4P5Q-A nrPDB 80 2e-15 4OLI-A nrPDB 80 2e-15 5MJB-A nrPDB 80 2e-15 4C0T-A nrPDB 79 2e-15 4TNB-A nrPDB 79 2e-15 5X3F-B nrPDB 79 2e-15 2Y6O-A nrPDB 79 3e-15 5VD3-A nrPDB 79 3e-15 3DLS-A nrPDB 79 3e-15 3VN9-A nrPDB 79 4e-15 3QD2-B nrPDB 79 4e-15 6DBM-A nrPDB 79 4e-15 4D2V-A nrPDB 79 4e-15 6ED6-A nrPDB 79 4e-15 3UIU-A nrPDB 79 4e-15 4U41-A nrPDB 78 7e-15 3DKO-A nrPDB 78 7e-15 4UYA-A nrPDB 77 7e-15 5L6P-A nrPDB 77 8e-15 3A4O-X nrPDB 77 9e-15 3RAW-A nrPDB 77 1e-14 6BXI-A nrPDB 77 1e-14 6BDL-A nrPDB 77 1e-14 2W1I-A nrPDB 76 2e-14 5TE0-A nrPDB 76 2e-14 4KIK-B nrPDB 76 3e-14 3IO7-A nrPDB 75 3e-14 2VWV-A nrPDB 75 3e-14 1LUF-A nrPDB 75 3e-14 3FME-A nrPDB 75 3e-14 3KUL-B nrPDB 75 3e-14 6FEX-A nrPDB 75 4e-14 3CJF-A nrPDB 75 4e-14 3NYO-A nrPDB 75 4e-14 4FZF-B nrPDB 75 5e-14 3LM0-A nrPDB 75 5e-14 6CTH-A nrPDB 75 5e-14 4RA4-A nrPDB 74 7e-14 4GS6-A nrPDB 74 1e-13 4UY9-A nrPDB 74 1e-13 1JPA-A nrPDB 74 1e-13 6FER-A nrPDB 74 1e-13 5TUR-A nrPDB 74 1e-13 3DTC-A nrPDB 74 1e-13 5VO2-A nrPDB 73 1e-13 5UIU-A nrPDB 73 2e-13 1VZO-A nrPDB 73 2e-13 4OTD-A nrPDB 73 2e-13 6BSD-A nrPDB 73 2e-13 5IKW-A nrPDB 73 2e-13 4YFF-A nrPDB 73 2e-13 2X7G-A nrPDB 73 2e-13 3BGP-A nrPDB 73 2e-13 3QA8-A nrPDB 73 2e-13 4RC3-A nrPDB 73 2e-13 5AMN-A nrPDB 72 2e-13 6NPU-A nrPDB 72 3e-13 4XEY-B nrPDB 72 3e-13 5U6C-A nrPDB 72 3e-13 4F9B-A nrPDB 72 4e-13 5H2U-A nrPDB 72 5e-13 4XUF-A nrPDB 72 5e-13 6GVJ-A nrPDB 72 5e-13 5X02-A nrPDB 72 5e-13 2QLU-A nrPDB 71 6e-13 4WUA-A nrPDB 71 6e-13 5O2B-A nrPDB 71 7e-13 4PDO-A nrPDB 71 7e-13 4AW2-A nrPDB 71 8e-13 5O2C-A nrPDB 71 8e-13 2XYN-A nrPDB 70 1e-12 4IDT-A nrPDB 70 1e-12 3SXS-A nrPDB 70 1e-12 2BUJ-A nrPDB 70 1e-12 3KA0-A nrPDB 70 1e-12 3FXW-A nrPDB 70 1e-12 3HMP-A nrPDB 70 1e-12 2OZA-A nrPDB 70 1e-12 4TPT-A nrPDB 70 2e-12 2FO0-A nrPDB 70 2e-12 1NY3-A nrPDB 70 2e-12 5AP3-A nrPDB 70 2e-12 5U6B-A nrPDB 70 2e-12 3TKU-A nrPDB 70 2e-12 6BFN-A nrPDB 69 2e-12 5LPZ-A nrPDB 69 2e-12 5HI2-A nrPDB 69 3e-12 5LPV-A nrPDB 69 3e-12 5TOS-A nrPDB 69 3e-12 5TQX-A nrPDB 69 3e-12 1U59-A nrPDB 69 4e-12 4HVI-A nrPDB 69 4e-12 3PFQ-A nrPDB 69 4e-12 2I0E-A nrPDB 68 4e-12 4YHJ-A nrPDB 68 5e-12 1TKI-A nrPDB 68 5e-12 1K9A-A nrPDB 68 5e-12 3PLS-A nrPDB 68 5e-12 4PWN-A nrPDB 68 5e-12 3SOC-A nrPDB 68 5e-12 2ZMD-A nrPDB 68 6e-12 5GNK-A nrPDB 68 6e-12 2H8H-A nrPDB 68 6e-12 5X5O-A nrPDB 68 6e-12 1BYG-A nrPDB 68 6e-12 2HK5-A nrPDB 68 7e-12 2OZO-A nrPDB 68 7e-12 4G3E-A nrPDB 68 7e-12 5FM2-A nrPDB 67 8e-12 2DQ7-X nrPDB 67 8e-12 3LZB-A nrPDB 67 9e-12 3PPZ-A nrPDB 67 1e-11 4X7Q-B nrPDB 67 1e-11 6E4F-A nrPDB 67 1e-11 6F3F-A nrPDB 67 1e-11 4Y93-A nrPDB 67 1e-11 3LLT-A nrPDB 66 2e-11 4NEU-A nrPDB 66 2e-11 4EBW-A nrPDB 66 2e-11 2QKW-B nrPDB 66 2e-11 4XI2-A nrPDB 66 2e-11 5HIE-A nrPDB 66 2e-11 3OMV-A nrPDB 66 2e-11 4AT3-A nrPDB 66 2e-11 4JLC-A nrPDB 66 2e-11 2PMN-X nrPDB 66 2e-11 3C1X-A nrPDB 65 3e-11 5SYS-A nrPDB 65 4e-11 4EUU-A nrPDB 65 4e-11 6O8B-A nrPDB 65 5e-11 5A46-A nrPDB 65 5e-11 1AD5-A nrPDB 65 5e-11 2PSQ-A nrPDB 65 5e-11 5HLW-A nrPDB 65 5e-11 4EUT-A nrPDB 65 5e-11 3VHK-A nrPDB 65 5e-11 6NT9-A nrPDB 65 6e-11 3GQL-A nrPDB 65 6e-11 3TT0-A nrPDB 64 1e-10 5EG3-A nrPDB 64 1e-10 6CKI-A nrPDB 64 1e-10 3HNG-A nrPDB 64 1e-10 2PL0-A nrPDB 63 2e-10 4LRM-A nrPDB 63 2e-10 4K33-A nrPDB 63 2e-10 2J0K-A nrPDB 63 2e-10 3ZZW-A nrPDB 62 3e-10 4M66-A nrPDB 62 3e-10 4Y12-A nrPDB 62 3e-10 3V5Q-A nrPDB 62 4e-10 6GQK-A nrPDB 62 4e-10 3BEA-A nrPDB 62 5e-10 3QUP-A nrPDB 61 6e-10 2PZI-A nrPDB 61 9e-10 1PY5-A nrPDB 60 1e-09 2OGV-A nrPDB 60 1e-09 5GRN-A nrPDB 59 3e-09 4XCU-A nrPDB 59 3e-09 5KMM-A nrPDB 59 4e-09 4LQP-A nrPDB 58 7e-09 4OW8-A nrPDB 57 8e-09 4FL3-A nrPDB 57 8e-09 2HW6-A nrPDB 57 8e-09 5C26-A nrPDB 57 9e-09 4X3F-A nrPDB 57 1e-08 3KRL-A nrPDB 57 1e-08 6B2Q-A nrPDB 57 1e-08 2VD5-A nrPDB 57 1e-08 2H34-A nrPDB 57 1e-08 5X1R-A nrPDB 56 2e-08 2Y4I-B nrPDB 56 2e-08 4R7H-A nrPDB 56 2e-08 3PP0-A nrPDB 56 2e-08 4F0G-A nrPDB 56 3e-08 2RIO-A nrPDB 55 3e-08 3UIM-A nrPDB 55 3e-08 5WNO-A nrPDB 55 4e-08 5XD6-A nrPDB 55 4e-08 1U54-B nrPDB 55 5e-08 3Q4U-A nrPDB 55 5e-08 4RT7-A nrPDB 55 6e-08 4HZS-A nrPDB 54 7e-08 4JRN-A nrPDB 54 7e-08 4PL5-B nrPDB 54 8e-08 3I81-A nrPDB 54 9e-08 6HV0-A nrPDB 54 1e-07 3MDY-A nrPDB 54 1e-07 4H1J-A nrPDB 53 2e-07 3LMG-A nrPDB 52 4e-07 4Y83-A nrPDB 52 4e-07 3G2F-A nrPDB 52 5e-07 3BBT-B nrPDB 51 6e-07 5M07-A nrPDB 51 7e-07 4M69-B nrPDB 50 1e-06 3ZBF-A nrPDB 50 1e-06 3G0E-A nrPDB 50 2e-06 3SV0-A nrPDB 50 2e-06 3M42-A nrPDB 50 2e-06 5WNL-A nrPDB 49 2e-06 4XLV-A nrPDB 49 2e-06 4BTF-A nrPDB 49 3e-06 2WTK-B nrPDB 48 5e-06 5L2Q-C nrPDB 48 5e-06 5VC6-A nrPDB 48 8e-06 3REP-A nrPDB 47 9e-06 5FQD-C nrPDB 47 9e-06 5AR8-A nrPDB 47 1e-05 4MWI-A nrPDB 47 2e-05 5E8V-A nrPDB 46 3e-05 2RSV-A nrPDB 45 4e-05 2LAV-A nrPDB 45 4e-05 2C47-A nrPDB 44 1e-04 5OAT-A nrPDB 44 1e-04 4XHH-A nrPDB 43 2e-04 5VDK-A nrPDB 43 2e-04 3AOX-A nrPDB 43 2e-04 4XHL-A nrPDB 43 2e-04 2CHL-A nrPDB 42 3e-04 2CMW-A nrPDB 42 4e-04 5CLR-A nrPDB 42 4e-04 3MY0-A nrPDB 41 7e-04 1CSN-A nrPDB 41 7e-04 4TN6-A nrPDB 41 8e-04 5UU1-A nrPDB 40 0.001 4L00-A nrPDB 40 0.001 5J0A-A nrPDB 40 0.001 6G4J-A nrPDB 40 0.001 5X18-A nrPDB 40 0.002 4IX6-A nrPDB 39 0.004 4NT4-A nrPDB 37 0.011 4L68-A nrPDB 35 0.048 4NFN-A nrPDB 34 0.094 6J6I-B nrPDB 34 0.10 4BTK-A nrPDB 34 0.11 6BQ8-A nrPDB 33 0.13 6EWX-A nrPDB 33 0.27 5VE6-A nrPDB 32 0.30 5VM9-A nrPDB 32 0.34 4CI6-B nrPDB 32 0.40 6EQI-C nrPDB 32 0.49 2A30-A nrPDB 32 0.59 4Q1A-A nrPDB 31 0.86 5UV4-A nrPDB 30 1.2 3ENH-A nrPDB 30 1.2 5DMZ-A nrPDB 30 1.8 1BXN-I nrPDB 30 2.2 4O1O-A nrPDB 29 2.9 5BQ5-A nrPDB 29 3.8 6G18-v nrPDB 28 4.2 3BYV-A nrPDB 28 4.3 4NSP-A nrPDB 28 4.3 4OAU-C nrPDB 28 4.4 6FDN-A nrPDB 28 5.1 3DZO-A nrPDB 27 8.9 >1UA2-A nrPDB Length = 346 Score = 716 bits (1847), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/346 (100%), Positives = 346/346 (100%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM Sbjct: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA Sbjct: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM Sbjct: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG Sbjct: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 301 PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 346 PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF Sbjct: 301 PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 346 >2BPM-A nrPDB Length = 309 Score = 277 bits (708), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 136/304 (44%), Positives = 197/304 (64%), Gaps = 5/304 (1%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + ++K++ +GEG + VYKAR+K T ++VA+KKI+L +E G+ TA+REI LL+EL Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLLKEL 63 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP-SHIKAYMLMTLQGLEYL 128 +HPNI+ LLD ++ + LVF+F+ DL+ + ++L P IK+Y+ LQGL + Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 123 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H H +LHRDLKP NLL++ G +KLADFGLA++FG P R YTH+VVT WYRAPE+L G + Sbjct: 124 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 183 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV- 247 Y VD+W++GCI AE++ R PGDS++DQL RIF TLGTP E WP + S+PDY Sbjct: 184 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 243 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL 307 +F + + +D L+ + ++P RI+A AL +F + P P +L Sbjct: 244 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 303 Query: 308 PRPN 311 RP+ Sbjct: 304 ERPH 307 >3NIZ-A nrPDB Length = 311 Score = 272 bits (695), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 133/290 (45%), Positives = 191/290 (65%), Gaps = 6/290 (2%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y+KL+ +GEG + VYKA+D + +IVA+K+I+L E GI TA+REI LL+EL Sbjct: 21 EKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDE---GIPSTAIREISLLKEL 76 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HPNI+ L+D + ++LVF+FME DL+ ++ +N L S IK Y+ L+G+ + H Sbjct: 77 HHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCH 136 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 QH ILHRDLKP NLL++ +G LKLADFGLA++FG P R+YTH+VVT WYRAP++L G++ Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-- 247 Y VD+W++GCI AE++ P PG +D DQL +IF LGTP +WP + LP + Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 TF+ F P I + +DL+ + F+P RI+A A+ YF + Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKD 306 >4AU8-A nrPDB Length = 296 Score = 265 bits (678), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 133/291 (45%), Positives = 188/291 (64%), Gaps = 5/291 (1%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +++YEKL+ +GEG + TV+KA+++ T++IVA+K+++L E G+ +ALREI LL+E Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDE---GVPSSALREICLLKE 61 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L H NI+ L D ++LVF+F + DL+ + L P +K+++ L+GL + Sbjct: 62 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H +LHRDLKP NLL++ NG LKLADFGLA++FG P R Y+ +VVT WYR P++LFGA+ Sbjct: 122 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 189 MYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 +Y +DMW+ GCI AEL P PG+ DQL RIF LGTPTEEQWP M LPDY Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 241 Query: 248 TFKSFPG-IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + +P L ++ DL+Q L NP RI+A +AL+ YFS+ Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292 >6GU6-A nrPDB Length = 302 Score = 256 bits (655), Expect = 8e-69, Method: Compositional matrix adjust. Identities = 130/290 (44%), Positives = 183/290 (63%), Gaps = 8/290 (2%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y K++ +GEG + VYK R K T Q+VA+KKI+L E G+ TA+REI LL+EL H Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIREISLLKELRH 65 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLH 129 PNI+ L D S + L+F+F+ DL+ + + S +K+Y+ LQG+ + H Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 +LHRDLKP NLL+D+ G +KLADFGLA++FG P R YTH+VVT WYR+PE+L G+ Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-T 248 Y VD+W++G I AEL + P GDS++DQL RIF LGTP E WP++ SL DY T Sbjct: 186 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 245 Query: 249 FKSF-PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 F + PG H+ ++ LDL+ + +++P RI+ AL YF++ Sbjct: 246 FPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 294 >1V0B-A nrPDB Length = 288 Score = 241 bits (616), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 121/287 (42%), Positives = 174/287 (60%), Gaps = 5/287 (1%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y L+ +GEG + VYKA++ N + A+KKI+L E GI T +REI +L+EL Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDE---GIPSTTIREISILKEL 57 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 H NI+ L D K + LVF+ ++ DL+ ++ L K+++L L G+ Y H Sbjct: 58 KHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCH 117 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 +LHRDLKP NLL++ G LK+ADFGLA++FG P R YTH+VVT WYRAP++L G++ Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY-VT 248 Y +D+W+VGCI AE++ P PG S+ DQL RIF LGTP + WP++ LP Y Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 F + +P + +DL+ + +P RITA QAL+ YF Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYF 284 >3GC0-A nrPDB Length = 329 Score = 241 bits (616), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 127/294 (43%), Positives = 179/294 (60%), Gaps = 11/294 (3%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY ++ LGEG + VYKA D TN+ VAIK+I+L H E G+ TA+RE+ LL+EL Sbjct: 35 RYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEE---GVPGTAIREVSLLKELQ 91 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 H NII L H + L+F++ E DL+ + N V + IK+++ + G+ + H Sbjct: 92 HRNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNPDV-SMRVIKSFLYQLINGVNFCHS 150 Query: 131 HWILHRDLKPNNLLLD-----ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 LHRDLKP NLLL E VLK+ DFGLA++FG P R +TH+++T WYR PE+L Sbjct: 151 RRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILL 210 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G+R Y VD+W++ CI AE+L++ P PGDS++DQL +IFE LG P + WP + +LPD Sbjct: 211 GSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALPD 270 Query: 246 Y-VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFL-FNPCARITATQALKMKYFSN 297 + +F F G L + A DD + L +P RI+A AL+ YFS+ Sbjct: 271 WKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSH 324 >4KRC-A nrPDB Length = 317 Score = 236 bits (602), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 121/301 (40%), Positives = 185/301 (61%), Gaps = 15/301 (4%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 S + ++++L+ LG G +ATVYK +K T VA+K++KL ++++G TA+REI L+ Sbjct: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL----DSEEGTPSTAIREISLM 57 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP-----SHIKAYMLMT 121 +EL H NI+ L D ++ ++LVF+FM+ DL+ + ++ TP + +K + Sbjct: 58 KELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQL 117 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 LQGL + H++ ILHRDLKP NLL+++ G LKL DFGLA++FG P ++ +VVT WYRAP Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAP 177 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 ++L G+R Y +D+W+ GCILAE++ P PG +D +QL IF+ +GTP E WP + Sbjct: 178 DVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVT 237 Query: 242 SLPDYV-TFKSFPGIPLH-----HIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 LP Y + P L H +L+D + GL NP R++A QAL +F Sbjct: 238 KLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWF 297 Query: 296 S 296 + Sbjct: 298 A 298 >5G6V-A nrPDB Length = 324 Score = 228 bits (582), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 119/287 (41%), Positives = 177/287 (61%), Gaps = 8/287 (2%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y KLD LGEG +ATVYK + K T+ +VA+K+I+L H ++G TA+RE+ LL++L H Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH----EEGAPCTAIREVSLLKDLKH 59 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 NI+ L D + +++LVF++++ DL+ + D ++ ++K ++ L+GL Y H+ Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 +LHRDLKP NLL++E G LKLADFGLA++ P + Y ++VVT WYR P++L G+ Y Sbjct: 120 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYS 179 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 +DMW VGCI E+ P PG + +QL IF LGTPTEE WP + S ++ T+ + Sbjct: 180 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY-N 238 Query: 252 FPGIPLHHIFSAA---GDDLLDLIQGLFLFNPCARITATQALKMKYF 295 +P + S A D DL+ L F RI+A A+K +F Sbjct: 239 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3MIA-A nrPDB Length = 351 Score = 213 bits (542), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 127/309 (41%), Positives = 179/309 (57%), Gaps = 21/309 (6%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +YEKL +G+G F V+KAR + T Q VA+KK+ + K+G TALREIK+LQ L Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLM---ENEKEGFPITALREIKILQLLK 74 Query: 71 HPNIIGLLDAFGHKSN--------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 H N++ L++ K++ I LVFDF E DL ++ + + T S IK M M L Sbjct: 75 HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-----GSPNRAYTHQVVTRW 177 GL Y+H++ ILHRD+K N+L+ +GVLKLADFGLA++F PNR YT++VVT W Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLW 193 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 YR PELL G R YG +D+W GCI+AE+ R P + G+++ QL I + G+ T E W Sbjct: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Query: 238 PDMCSLPDYVTFKSFPGI--PLHHIFSAAGDD--LLDLIQGLFLFNPCARITATQALKMK 293 P++ + Y + G + A D LDLI L + +P RI + AL Sbjct: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 Query: 294 YFSNRPGPT 302 +F + P P+ Sbjct: 314 FFWSDPMPS 322 >5EFQ-A nrPDB Length = 347 Score = 208 bits (529), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 120/343 (34%), Positives = 190/343 (55%), Gaps = 23/343 (6%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 K +++ + +GEG + VYKARDK+T ++VA+KK++L + K+G TA+REIK+ Sbjct: 7 KRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNE---KEGFPITAIREIKI 63 Query: 66 LQELSHPNIIGL----------LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIK 115 L++L+H +II + LD K LVF++M+ DL +++ + +HIK Sbjct: 64 LRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIK 123 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-NRAYTHQVV 174 ++M ++GL+Y H+ LHRD+K +N+LL+ G +KLADFGLA+ + S +R YT++V+ Sbjct: 124 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 T WYR PELL G Y +D+W+ GCIL EL + P + +L QL I G+P Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCP 243 Query: 235 EQWPDMCSLPDYVTFKSFPGI--PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 WPD+ LP + T K L F LDL + +P R TA QAL+ Sbjct: 244 AVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQC 303 Query: 293 KYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEAL 335 ++ + ++P P+ P L + + + KR+R + + Sbjct: 304 EFLRD----VEPSKMPPPDLP---LWQDCHELWSKKRRRQKQM 339 >4AGU-A nrPDB Length = 311 Score = 206 bits (525), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 119/301 (39%), Positives = 170/301 (56%), Gaps = 26/301 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++YEK+ +GEG + V+K R+++T QIVAIKK SE I + ALREI++L++L Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFL---ESEDDPVIKKIALREIRMLKQL 59 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK-DNSLVLTPSH-IKAYMLMTLQGLEY 127 HPN++ LL+ F K + LVF++ D V+ + D P H +K+ TLQ + + Sbjct: 60 KHPNLVNLLEVFRRKRRLHLVFEY--CDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNF 117 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 H+H +HRD+KP N+L+ ++ V+KL DFG A+ P+ Y +V TRWYR+PELL G Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG--TPTEEQWPDMCSLPD 245 YG VD+WA+GC+ AELL VP PG SD+DQL I +TLG P +Q Sbjct: 178 TQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV-------- 229 Query: 246 YVTFKSFPGI---------PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + T + F G+ PL F L L++G +P R+T Q L YF Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 Query: 297 N 297 N Sbjct: 290 N 290 >4NST-A nrPDB Length = 351 Score = 204 bits (518), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 110/300 (36%), Positives = 173/300 (57%), Gaps = 16/300 (5%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +++ + +GEG + VYKA+DK+T ++VA+KK++L + K+G TA+REIK+L++L Sbjct: 14 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNE---KEGFPITAIREIKILRQLI 70 Query: 71 HPNIIGL----------LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 H +++ + LD K LVF++M+ DL +++ + + HIK++M Sbjct: 71 HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQ 130 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-NRAYTHQVVTRWYR 179 ++GLEY H+ LHRD+K +N+LL+ +G +KLADFGLA+ + S +R YT++V+T WYR Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 PELL G Y +D+W+ GCIL EL + P + +L QL I G+P WPD Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 250 Query: 240 MCSLPDYVTFKSFPGI--PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + LP + T K L FS LDL+ + +P R TA Q L+ + + Sbjct: 251 VIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKD 310 >4BGQ-A nrPDB Length = 304 Score = 196 bits (497), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 111/301 (36%), Positives = 167/301 (55%), Gaps = 11/301 (3%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 ++ + ++E L +GEG + V K R K T++IVAIKK K SE + + T LRE+ Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK---DSEENEEVKETTLREL 62 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 K+L+ L NI+ L +AF + + LVF+++E ++ ++++ + P +K+Y+ ++ Sbjct: 63 KMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIK 122 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA-YTHQVVTRWYRAPE 182 + + H++ I+HRD+KP NLL+ N VLKL DFG A++ N A Y +V TRWYR+PE Sbjct: 123 AIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPE 182 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 LL GA YG VDMW+VGCIL EL P PG+S++DQL I + LG EQ S Sbjct: 183 LLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 241 Query: 243 LPDYVTFKSFPGIP-----LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 P + + FP + LLDL++ L +P R Q L F Sbjct: 242 NPRFHGLR-FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 300 Query: 298 R 298 + Sbjct: 301 Q 301 >1G3N-A nrPDB Length = 326 Score = 195 bits (496), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 112/298 (37%), Positives = 170/298 (57%), Gaps = 16/298 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++YE + +GEG + V+KARD KN + VA+K++++ ++G+ + +RE+ +L+ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV---QTGEEGMPLSTIREVAVLRH 67 Query: 69 LS---HPNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDNSLVLTPSH-IKAYML 119 L HPN++ L D ++ ++LVF+ ++ DL + P+ IK M Sbjct: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L+GL++LH H ++HRDLKP N+L+ +G +KLADFGLA+ + S A T VVT WYR Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY-SFQMALTSVVVTLWYR 186 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L + Y VD+W+VGCI AE+ R P G SD+DQL +I + +G P EE WP Sbjct: 187 APEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 +LP F S P+ + + DL+ FNP RI+A AL YF + Sbjct: 246 DVALPRQ-AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQD 302 >4BBM-A nrPDB Length = 331 Score = 193 bits (491), Expect = 9e-50, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 162/301 (53%), Gaps = 19/301 (6%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++YE L +GEG + V K R+K+T +IVAIKK S+ + + A+REIKLL++L Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFL---ESDDDKMVKKIAMREIKLLKQL 81 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV---LTPSHIKAYMLMTLQGLE 126 H N++ LL+ K LVF+F++ I+ D L L ++ Y+ + G+ Sbjct: 82 RHENLVNLLEVCKKKKRWYLVFEFVD---HTILDDLELFPNGLDYQVVQKYLFQIINGIG 138 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + H H I+HRD+KP N+L+ ++GV+KL DFG A++ +P Y +V TRWYRAPELL G Sbjct: 139 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVG 198 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 YG VD+WA+GC++ E+ + P PGDSD+DQL I LG P + Sbjct: 199 DVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVF 258 Query: 247 VTFKSFPGI----PLHHIFSAAGDDLLDLIQGLFLFNP-----CARITATQALKMKYFSN 297 + P I PL + + ++DL + +P CA + +M F+ Sbjct: 259 AGVR-LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAE 317 Query: 298 R 298 R Sbjct: 318 R 318 >2W96-B nrPDB Length = 306 Score = 189 bits (481), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 111/300 (37%), Positives = 166/300 (55%), Gaps = 15/300 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 RYE + +G G + TVYKARD ++ VA+K +++ ++G+ + +RE+ LL+ L Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRV---PNGEEGLPISTVREVALLRRL 60 Query: 70 S---HPNIIGLLDAFG-----HKSNISLVFDFMETDLEVIIKDNSLVLTPSH-IKAYMLM 120 HPN++ L+D + ++LVF+ ++ DL + P+ IK M Sbjct: 61 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 120 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L+GL++LH + I+HRDLKP N+L+ G +KLADFGLA+ + S A VVT WYRA Sbjct: 121 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALDPVVVTLWYRA 179 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE+L + Y VDMW+VGCI AE+ R P G+S+ DQL +IF+ +G P E+ WP Sbjct: 180 PEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 238 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 SLP F P+ + + L+ + FNP RI+A +AL+ Y G Sbjct: 239 VSLPRG-AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 297 >5NGU-A nrPDB Length = 381 Score = 188 bits (478), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 117/305 (38%), Positives = 162/305 (53%), Gaps = 21/305 (6%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIK-LGHRSEAKDGINRTALREIKLLQEL 69 RY L ++GEG + V A D VAIKKI H++ + RT LREIK+L Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQ----RT-LREIKILLRF 97 Query: 70 SHPNIIGLLD-----AFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 H NIIG+ D ++ +V D METDL ++K L + HI ++ L+G Sbjct: 98 RHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHL--SNDHICYFLYQILRG 155 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRA 180 L+Y+H +LHRDLKP+NLLL+ LK+ DFGLA+ P+ +T V TRWYRA Sbjct: 156 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDHTGFLTEYVATRWYRA 214 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ ++ Y +D+W+VGCILAE+L P PG LDQL I LG+P++E + Sbjct: 215 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 274 Query: 241 CSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 +L S P +P + +F A LDL+ + FNP RI QAL Y Sbjct: 275 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 Query: 298 RPGPT 302 P+ Sbjct: 335 YYDPS 339 >3ZDU-A nrPDB Length = 325 Score = 187 bits (476), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 99/294 (33%), Positives = 161/294 (54%), Gaps = 19/294 (6%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 YE L +GEG + TV K + KNT QIVAIK + +N+ A+REIK L++ H Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF----YERPEQSVNKIAMREIKFLKQFHH 60 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 N++ L++ F K I LVF+F++ + ++ L ++ Y+ L+ ++YLH + Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 120 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 I+HRD+KP N+L+ ++G+ KL DFG A++ +P Y +V TRWYRAPEL+ YG Sbjct: 121 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 VD+WA+GC++ E+ P+LP SDLD L +I +G + P + ++ + Sbjct: 181 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLS----PHLQNI--FSKSPI 234 Query: 252 FPGIPLHHI---------FSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 F G+ L + + L D++ +P RI+++ L +YF+ Sbjct: 235 FAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >4QTB-A nrPDB Length = 380 Score = 186 bits (471), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 113/304 (37%), Positives = 162/304 (53%), Gaps = 19/304 (6%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY +L ++GEG + V A D VAIKKI E + RT LREI++L Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS---PFEHQTYCQRT-LREIQILLRFR 97 Query: 71 HPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 H N+IG+ D + ++ +V D METDL ++K S L+ HI ++ L+GL Sbjct: 98 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGL 155 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAP 181 +Y+H +LHRDLKP+NLL++ LK+ DFGLA+ P +T V TRWYRAP Sbjct: 156 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAP 214 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 E++ ++ Y +D+W+VGCILAE+L P PG LDQL I LG+P++E + Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 242 SLPDYVTFKSFPG---IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 ++ +S P + +F + LDL+ + FNP RIT +AL Y Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 334 Query: 299 PGPT 302 PT Sbjct: 335 YDPT 338 >3OZ6-A nrPDB Length = 388 Score = 184 bits (467), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 119/346 (34%), Positives = 180/346 (52%), Gaps = 60/346 (17%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKI--KLGHRSEAKDGINRTALREIKLLQ 67 ++YE + LG+G + V+K+ D+ T ++VA+KKI + ++A+ RT REI +L Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQ----RT-FREIMILT 63 Query: 68 ELS-HPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 ELS H NI+ LL+ + ++ LVFD+METDL +I+ N +L P H + + ++ Sbjct: 64 ELSGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRAN--ILEPVHKQYVVYQLIKV 121 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA---------------- 168 ++YLH +LHRD+KP+N+LL+ +K+ADFGL++SF + R Sbjct: 122 IKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFD 181 Query: 169 -----YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLT 223 T V TRWYRAPE+L G+ Y G+DMW++GCIL E+L P PG S ++QL Sbjct: 182 DDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLE 241 Query: 224 RIFETLGTPTEEQWPDMC---------SLPDYVTFKSFPGIPLHHIFSA----------- 263 RI + P+ E + SL + V + IF+ Sbjct: 242 RIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNK---RDIFTKWKNLLLKINPK 298 Query: 264 --AGDDLLDLIQGLFLFNPCARITATQALKMKYFS--NRPGPTPGC 305 ++ LDL+ L FNP RI+A ALK + S + P P C Sbjct: 299 ADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNC 344 >4ZSG-A nrPDB Length = 347 Score = 184 bits (466), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 110/314 (35%), Positives = 165/314 (52%), Gaps = 23/314 (7%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN--RTALREIKLLQEL 69 YE ++ +G G + V AR + T Q VAIKKI A D + + LRE+K+L+ Sbjct: 9 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKI-----PNAFDVVTNAKRTLRELKILKHF 63 Query: 70 SHPNIIGLLDA------FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 H NII + D +G ++ +V D ME+DL II +S LT H++ ++ L+ Sbjct: 64 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH-SSQPLTLEHVRYFLYQLLR 122 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY----THQVVTRWYR 179 GL+Y+H ++HRDLKP+NLL++EN LK+ DFG+A+ + + T V TRWYR Sbjct: 123 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 182 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APEL+ Y +D+W+VGCI E+L R PG + + QL I LGTP+ Sbjct: 183 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 240 MCSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + + +S P +P ++ A L L+ + F P ARI+A AL+ + + Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 302 Query: 297 --NRPGPTPGCQLP 308 + P P C P Sbjct: 303 KYHDPDDEPDCAPP 316 >4IC8-A nrPDB Length = 442 Score = 183 bits (465), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 110/314 (35%), Positives = 165/314 (52%), Gaps = 23/314 (7%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN--RTALREIKLLQEL 69 YE ++ +G G + V AR + T Q VAIKKI A D + + LRE+K+L+ Sbjct: 57 YEIIETIGNGAYGVVSSARRRLTGQQVAIKKI-----PNAFDVVTNAKRTLRELKILKHF 111 Query: 70 SHPNIIGLLD------AFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 H NII + D +G ++ +V D ME+DL II +S LT H++ ++ L+ Sbjct: 112 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIH-SSQPLTLEHVRYFLYQLLR 170 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY----THQVVTRWYR 179 GL+Y+H ++HRDLKP+NLL++EN LK+ DFG+A+ + + T V TRWYR Sbjct: 171 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 230 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APEL+ Y +D+W+VGCI E+L R PG + + QL I LGTP+ Sbjct: 231 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 240 MCSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + + +S P +P ++ A L L+ + F P ARI+A AL+ + + Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 350 Query: 297 --NRPGPTPGCQLP 308 + P P C P Sbjct: 351 KYHDPDDEPDCAPP 364 >3GC9-A nrPDB Length = 370 Score = 183 bits (464), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 110/301 (36%), Positives = 160/301 (53%), Gaps = 17/301 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +R + L +G G + +V A D Q VA+KK+ +S R RE++LL+ L Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH---ARRTYRELRLLKHL 84 Query: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 H N+IGLLD F ++I LV M DL I+K S L+ H++ + L+ Sbjct: 85 KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--SQALSDEHVQFLVYQLLR 142 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GL+Y+H I+HRDLKP+N+ ++E+ L++ DFGLA+ Y V TRWYRAPE+ Sbjct: 143 GLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGY---VATRWYRAPEI 199 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y VD+W+VGCI+AELL PG +DQL RI E +GTP+ E + S Sbjct: 200 MLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSE 259 Query: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 +S P +P L IF A +DL+ + + + R++A +AL YFS Sbjct: 260 HARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHD 319 Query: 301 P 301 P Sbjct: 320 P 320 >5Z33-A nrPDB Length = 425 Score = 181 bits (459), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 115/298 (38%), Positives = 161/298 (54%), Gaps = 16/298 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +RY LG+G + V A + T++ VAIKK+ +K + + ALREIKLLQ Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVT---NVFSKKILAKRALREIKLLQHF 87 Query: 70 -SHPNIIGLLDA-FGHKSNISLVF---DFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 H NI L D N + + + ME DL II+ LT +H ++++ L G Sbjct: 88 RGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQ-PLTDAHFQSFIYQILCG 146 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG---SPNRAY-THQVVTRWYRA 180 L+Y+H +LHRDLKP NLL++ + LK+ DFGLA+ F N Y T V TRWYRA Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ + Y +D+W+VGCILAELL PF G +DQL +I LGTP EE + Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 241 CSLPDYVTFKSFPGI---PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 S ++ P + P +F A D LDL+ + F+P +RI+ QAL+ Y Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 >2F9G-A nrPDB Length = 353 Score = 179 bits (455), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 108/305 (35%), Positives = 160/305 (52%), Gaps = 25/305 (8%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 LGEG + V A K T +IVAIKKI+ K LREIK+L+ H NII Sbjct: 18 LLGEGAYGVVCSATHKPTGEIVAIKKIE----PFDKPLFALRTLREIKILKHFKHENIIT 73 Query: 77 LL-----DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 + D+F + + + ++ + M+TDL +I ++ +L+ HI+ ++ TL+ ++ LH Sbjct: 74 IFNIQRPDSFENFNEVYIIQELMQTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVLHGS 131 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP----------NRAYTHQVVTRWYRAP 181 ++HRDLKP+NLL++ N LK+ DFGLA+ T V TRWYRAP Sbjct: 132 NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAP 191 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 E++ + Y +D+W+ GCILAEL LR P PG QL IF +GTP + Sbjct: 192 EVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCI 251 Query: 242 SLP---DYV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 P +Y+ + +P PL +F +DL+Q + +F+P RITA +AL+ Y Sbjct: 252 ESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQT 311 Query: 298 RPGPT 302 P Sbjct: 312 YHDPN 316 >5AIR-A nrPDB Length = 430 Score = 179 bits (454), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 113/300 (37%), Positives = 163/300 (54%), Gaps = 31/300 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y +G G F VY+A+ ++ ++VAIKK+ R + RE++++++L H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKLDH 116 Query: 72 PNIIGLLDAF---GHKSN---ISLVFDFMETDLEVIIKDNSL---VLTPSHIKAYMLMTL 122 NI+ L F G K + ++LV D++ + + + S L ++K YM Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 176 Query: 123 QGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYR 179 + L Y+H I HRD+KP NLLLD + VLKL DFG AK G PN +Y + +R+YR Sbjct: 177 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYR 233 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APEL+FGA Y +D+W+ GC+LAELLL P PGDS +DQL I + LGTPT EQ + Sbjct: 234 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 293 Query: 240 MCSLPDYVTFKSFPGIPLH---HIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 M P+Y FK FP I H +F + + L L + P AR+T +A +F Sbjct: 294 MN--PNYTEFK-FPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 350 >6DTL-A nrPDB Length = 364 Score = 178 bits (452), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 112/301 (37%), Positives = 163/301 (54%), Gaps = 16/301 (5%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G+G + V A + TN+ VAIKKI + + K RT LREIKLL+ + H NI+ + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKI--ANAFDNKIDAKRT-LREIKLLRHMDHENIVAI 94 Query: 78 LDAF-----GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 D +++ + ++ M+TDL II+ N L+ H + ++ L+GL+Y+H Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ-ALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 +LHRDLKP+NLLL+ N LK+ DFGLA+ S + T VVTRWYRAPELL + Y Sbjct: 154 VLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDYTA 212 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 +D+W+VGCI EL+ R P PG + QL + E +GTP+EE+ + + Sbjct: 213 AIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY-IRQL 271 Query: 253 PGIPLHHI---FSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS--NRPGPTPGCQL 307 P P I F +DLI+ + F+P RIT AL Y + + P C + Sbjct: 272 PPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEPECTI 331 Query: 308 P 308 P Sbjct: 332 P 332 >4CRL-A nrPDB Length = 406 Score = 176 bits (447), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 113/299 (37%), Positives = 155/299 (51%), Gaps = 44/299 (14%) Query: 54 GINRTALREIKLLQELSHPNIIGLLDAFGHKSN--ISLVFDFMETDLEVIIK-------- 103 GI+ +A REI LL+EL HPN+I L F ++ + L+FD+ E DL IIK Sbjct: 61 GISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKAN 120 Query: 104 DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL----DENGVLKLADFGLA 159 + L +K+ + L G+ YLH +W+LHRDLKP N+L+ E G +K+AD G A Sbjct: 121 KKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFA 180 Query: 160 KSFGSPNRAYTH---QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVP-FLPG 215 + F SP + VVT WYRAPELL GAR Y +D+WA+GCI AELL P F Sbjct: 181 RLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCR 240 Query: 216 DSDL--------DQLTRIFETLGTPTEEQWPDMCSLPDYVTF------KSFPGIPL---- 257 D+ DQL RIF +G P ++ W D+ +P++ T ++ L Sbjct: 241 QEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM 300 Query: 258 --HHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP----GCQLPRP 310 H + L+Q L +P RIT+ QA++ YF P PT GCQ+P P Sbjct: 301 EKHKV--KPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYP 357 >4EWQ-A nrPDB Length = 383 Score = 174 bits (441), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 107/301 (35%), Positives = 159/301 (52%), Gaps = 17/301 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +RY+ L +G G + +V A D T VA+KK+ +S + RE++LL+ + Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH---AKRTYRELRLLKHM 101 Query: 70 SHPNIIGLLDAFG------HKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 H N+IGLLD F +++ LV M DL I+K L T H++ + L+ Sbjct: 102 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKL--TDDHVQFLIYQILR 159 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GL+Y+H I+HRDLKP+NL ++E+ LK+ DFGLA+ Y V TRWYRAPE+ Sbjct: 160 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEI 216 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y VD+W+VGCI+AELL PG +DQL I +GTP E + S Sbjct: 217 MLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSE 276 Query: 244 P--DYV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 +Y+ + P + ++F A +DL++ + + + RITA QAL YF+ Sbjct: 277 SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHD 336 Query: 301 P 301 P Sbjct: 337 P 337 >4QNY-A nrPDB Length = 354 Score = 171 bits (432), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 102/290 (35%), Positives = 156/290 (53%), Gaps = 12/290 (4%) Query: 11 RYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 RY +G G + V +ARD K+ N++VA+K++ E + + LREIKLL Sbjct: 21 RYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVI--LAKRILREIKLLAHF 78 Query: 70 SHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 + NIIGL + + + +V D METDL+ +++ LT +HI+ ++ L+ Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQ-ELTEAHIQFFIYQALRA 137 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 L +H ++HRD+ P N+L++ N LK+ DFGLAK T V RWYRAPEL+ Sbjct: 138 LHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELV 197 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS-- 242 + Y +D+W +GCIL ELL P G ++QL +I + +GTP+EE + S Sbjct: 198 MEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSA 257 Query: 243 LPDYVTFKSF-PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 Y+ KS P + A + LDL++ + +FNP RIT QA++ Sbjct: 258 AQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMR 307 >3OHT-A nrPDB Length = 389 Score = 170 bits (431), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 104/301 (34%), Positives = 158/301 (52%), Gaps = 17/301 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +RY+ L +G G + +V + D + +A+KK+ +S + RE++LL+ + Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIH---AKRTYRELRLLKHM 107 Query: 70 SHPNIIGLLDAFGHKS------NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 H N+IGLLD F + ++ LV M DL I+K L T H++ + L+ Sbjct: 108 KHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKL--TDDHVQFLIYQILR 165 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GL+Y+H I+HRDLKP+NL ++E+ LK+ DFGLA+ Y V TRWYRAPE+ Sbjct: 166 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEI 222 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y + VD+W+VGCI+AELL PG ++QL +I GTP M S Sbjct: 223 MLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSH 282 Query: 244 PDYVTFKSFPGIPLHH---IFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 S P +P + +F A +DL++ + + + RITA++AL YFS Sbjct: 283 EARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHD 342 Query: 301 P 301 P Sbjct: 343 P 343 >4MYG-A nrPDB Length = 372 Score = 170 bits (430), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 107/310 (34%), Positives = 158/310 (50%), Gaps = 18/310 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K Y +G G + +V A DK + + VAIKK+ +SE + A RE+ LL+ + Sbjct: 43 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI---FAKRAYRELLLLKHM 99 Query: 70 SHPNIIGLLDAFGHKSNIS------LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 H N+IGLLD F S++ LV FM+TDL+ I+ + + I+ + L+ Sbjct: 100 QHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLK 156 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GL+Y+H ++HRDLKP NL ++E+ LK+ DFGLA+ + Y VVTRWYRAPE+ Sbjct: 157 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEV 213 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y VD+W+VGCI+AE+L G LDQLT+I + G P E + Sbjct: 214 ILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDK 273 Query: 244 PDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 +S P P +F A DL++ + + R+TA QAL +F Sbjct: 274 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRD 333 Query: 301 PTPGCQLPRP 310 P + +P Sbjct: 334 PEEETEAQQP 343 >4E7W-A nrPDB Length = 394 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 118/314 (37%), Positives = 171/314 (54%), Gaps = 35/314 (11%) Query: 1 MALDVKSRAKR---YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR 57 +A D K+ +R Y +G G F V++A+ +++ VAIKK+ R + Sbjct: 28 LASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------ 80 Query: 58 TALREIKLLQELSHPNIIGLLDAF---GHKSN---ISLVFDFM-ETDLEVIIKDNSLVLT 110 RE+++++ + HPN++ L F G K + ++LV +++ ET L T Sbjct: 81 ---RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQT 137 Query: 111 PSH--IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE-NGVLKLADFGLAKSF--GSP 165 IK YM L+ L Y+H I HRD+KP NLLLD +GVLKL DFG AK G P Sbjct: 138 MPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEP 197 Query: 166 NRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 N +Y + +R+YRAPEL+FGA Y +D+W+ GC++AEL+ P PG+S +DQL I Sbjct: 198 NVSY---ICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEI 254 Query: 226 FETLGTPTEEQWPDMCSLPDYVTFKSFPGI---PLHHIFSA-AGDDLLDLIQGLFLFNPC 281 + LGTP+ EQ M P+Y+ K FP I P +F D +DLI L + P Sbjct: 255 IKVLGTPSREQIKTMN--PNYMEHK-FPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPS 311 Query: 282 ARITATQALKMKYF 295 AR+TA +AL +F Sbjct: 312 ARLTAIEALCHPFF 325 >3PG1-A nrPDB Length = 362 Score = 167 bits (423), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 97/255 (38%), Positives = 137/255 (53%), Gaps = 12/255 (4%) Query: 57 RTALREIKLLQELSHPNIIGLLDAFGH-----KSNISLVFDFMETDLEVIIKDNSLVLTP 111 + LREI+LL HPNI+GL D F H + LV + M TDL +I D +V++P Sbjct: 74 KRVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISP 133 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH 171 HI+ +M L GL LH+ ++HRDL P N+LL +N + + DF LA+ + + TH Sbjct: 134 QHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLARE-DTADANKTH 192 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 V RWYRAPEL+ + + VDMW+ GC++AE+ R G + +QL +I E +GT Sbjct: 193 YVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGT 252 Query: 232 PTEEQWPDMCSLP---DYV--TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 P E M S P DY+ + + P + A LDLI + FNP RI+ Sbjct: 253 PKIEDVV-MFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRIST 311 Query: 287 TQALKMKYFSNRPGP 301 QAL+ YF + P Sbjct: 312 EQALRHPYFESLFDP 326 >1CM8-A nrPDB Length = 367 Score = 162 bits (409), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 105/295 (35%), Positives = 150/295 (50%), Gaps = 17/295 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y L +G G + V A D T VAIKK+ +SE + A RE++LL+ + H Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL---FAKRAYRELRLLKHMRH 83 Query: 72 PNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 N+IGLLD F ++ LV FM TDL ++K L I+ + L+GL Sbjct: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKL--GEDRIQFLVYQMLKGL 141 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y+H I+HRDLKP NL ++E+ LK+ DFGLA+ S Y VVTRWYRAPE++ Sbjct: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVIL 198 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Y VD+W+VGCI+AE++ G LDQL I + GTP E + S Sbjct: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Query: 246 YVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 K P + I + A ++L++ + + + R+TA +AL YF + Sbjct: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFES 313 >2I6L-A nrPDB Length = 320 Score = 160 bits (406), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 104/311 (33%), Positives = 162/311 (52%), Gaps = 33/311 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 RY L LG G V+ A D + ++ VAIKKI L K ALREIK+++ Sbjct: 10 GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKH-----ALREIKIIRR 64 Query: 69 LSHPNIIGLLDAFG--------------HKSNISLVFDFMETDLEVIIKDNSLVLTPSHI 114 L H NI+ + + G +++ +V ++METDL +++ L+ H Sbjct: 65 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLL--EEHA 122 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQ- 172 + +M L+GL+Y+H +LHRDLKP NL ++ E+ VLK+ DFGLA+ + Y+H+ Sbjct: 123 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM---DPHYSHKG 179 Query: 173 -----VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 +VT+WYR+P LL Y +DMWA GCI AE+L G +L+Q+ I E Sbjct: 180 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 239 Query: 228 TLGTPTEEQWPDMCS-LPDYV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 ++ EE ++ S +P Y+ + P PL + + +D ++ + F+P R+T Sbjct: 240 SIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLT 299 Query: 286 ATQALKMKYFS 296 A +AL Y S Sbjct: 300 AEEALSHPYMS 310 >4O2Z-A nrPDB Length = 377 Score = 155 bits (391), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 101/337 (29%), Positives = 162/337 (48%), Gaps = 31/337 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +Y L LG G + D +T + V+IKK + R + +DG + LREI +++ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFR-DVEDG--KRVLREIDMMRFF 101 Query: 70 SHPNIIGLLD-------AFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 H N++ +++ + ++ +V M+ D+ V+++ VL SH++ ++ L Sbjct: 102 HHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQ-VLEESHMQYFVYQIL 160 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +GL+YLH + HRDLKP NL+ + + LK+ DFGL++S P T V+TRWYR PE Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPE 220 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT------EEQ 236 LL Y VD+W+VGCI AE+ R P PG + +DQL I + +G P E Sbjct: 221 LLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREA 280 Query: 237 WPDMCSLPD--YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 + LPD K PG+ A + +D + ++ +P R TA L Y Sbjct: 281 LEKLNELPDGSLNIPKLVPGL-------AGNTEGIDFLSKMWTLDPSKRPTAADMLAHPY 333 Query: 295 FSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKR 331 ++ + P CP L + + + R Sbjct: 334 LAHLHD-----EEDEPTCPCPFLWAHESTPMGVSELR 365 >3N9X-A nrPDB Length = 432 Score = 154 bits (389), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 111/341 (32%), Positives = 161/341 (47%), Gaps = 66/341 (19%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQELSHPNII 75 +G G + VY A DKNT + VAIKK+ +D I+ + LREI +L L II Sbjct: 33 LIGRGSYGYVYLAYDKNTEKNVAIKKV----NRMFEDLIDCKRILREITILNRLKSDYII 88 Query: 76 GLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L D + +V + ++DL+ + K + LT HIK + L G ++H+ Sbjct: 89 RLYDLIIPDDLLKFDELYIVLEIADSDLKKLFK-TPIFLTEEHIKTILYNLLLGENFIHE 147 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP----------------------NRA 168 I+HRDLKP N LL+++ +K+ DFGLA++ S + Sbjct: 148 SGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQ 207 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-----------LRVPFLPGD- 216 T VVTRWYRAPEL+ Y +D+W+ GCI AELL R P PG Sbjct: 208 LTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSS 267 Query: 217 ----------------SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF-KSFPG---IP 256 S+ DQL IF +GTPTE+ ++ + P+ + + K FP I Sbjct: 268 CFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNI-NKPEVIKYIKLFPHRKPIN 326 Query: 257 LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 L + + DD ++L++ + FNP RIT QAL Y + Sbjct: 327 LKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >5ZTN-A nrPDB Length = 429 Score = 153 bits (387), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 110/337 (32%), Positives = 172/337 (51%), Gaps = 51/337 (15%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A RYE L +G+G F V KA D +Q VA+K + R+E + +R A EI++L+ Sbjct: 96 AYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV----RNEKR--FHRQAAEEIRILEH 149 Query: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMT 121 L N+I +L+ F +++I + F+ + +L +IK N + ++ + Sbjct: 150 LRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSI 209 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 LQ L+ LH++ I+H DLKP N+LL + G +K+ DFG S R YT+ + +R+YR Sbjct: 210 LQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTY-IQSRFYR 266 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE++ GAR YG+ +DMW++GCILAELL P LPG+ + DQL + E LG P+++ Sbjct: 267 APEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDA 325 Query: 240 MCSLPDYVTFKSFP--------------------------GIPLHHIFSAA---GDD--L 268 ++V+ K +P G P + A DD Sbjct: 326 SKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLF 385 Query: 269 LDLIQGLFLFNPCARITATQALKMKYFSNR-PGPTPG 304 LD ++ ++P R+T QAL+ + R P P G Sbjct: 386 LDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTG 422 >3RP9-A nrPDB Length = 458 Score = 151 bits (382), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 110/352 (31%), Positives = 162/352 (46%), Gaps = 72/352 (20%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQEL 69 RYE +G G + V +A DK ++VAIKKI +D I+ + LREI +L L Sbjct: 54 RYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI----LRVFEDLIDCKRILREIAILNRL 109 Query: 70 SHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +H +++ +LD K + +V + ++D + + + + LT HIK + L G Sbjct: 110 NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFR-TPVYLTELHIKTLLYNLLVG 168 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN------------------ 166 ++Y+H ILHRDLKP N L++++ +K+ DFGLA++ P Sbjct: 169 VKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLV 228 Query: 167 ---------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL--------- 208 R T VVTRWYRAPEL+ Y +D+W++GCI AELL Sbjct: 229 TFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYH 288 Query: 209 --RVPFLPGDS--------------------DLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 R P PG S + DQL IF LGTP+EE + Sbjct: 289 ADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAK 348 Query: 247 VTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + FP G L F A+ D + L++ + +FNP RIT + L +F Sbjct: 349 RYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFF 400 >3NIE-A nrPDB Length = 429 Score = 150 bits (379), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 110/348 (31%), Positives = 158/348 (45%), Gaps = 67/348 (19%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQELS 70 YE +G G + VY A DKN N+ VAIKK+ +D I+ + LREI +L L Sbjct: 30 YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKV----NRMFEDLIDCKRILREITILNRLK 85 Query: 71 HPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 II L D + + +V + ++DL+ + K + LT H+K + L G Sbjct: 86 SDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFK-TPIFLTEQHVKTILYNLLLGE 144 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-------------------- 165 +++H+ I+HRDLKP N LL+++ +K+ DFGLA++ S Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 166 -----NRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-----------LR 209 + T VVTRWYRAPEL+ Y +D+W+ GCI AELL R Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 210 VPFLPGD-----------------SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 P PG S+ DQL IF +GTP EE + K F Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 253 P---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 P GI L +S+ + +DL++ + FN RIT +AL Y + Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD 372 >3E3P-A nrPDB Length = 360 Score = 145 bits (365), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 105/325 (32%), Positives = 164/325 (50%), Gaps = 36/325 (11%) Query: 2 ALDVKSRAK--RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA 59 A D +SR + R++ G+G F TV ++K+T VAIKK+ +D R Sbjct: 13 AADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV-------IQDPRFRN- 64 Query: 60 LREIKLLQELS---HPNIIGLLDAF---GHKSN----ISLVFDFMETDLEVIIKD---NS 106 RE++++Q+L+ HPNI+ L F G + +++V +++ L ++ Sbjct: 65 -RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQ 123 Query: 107 LVLTPSHIKAYMLMTLQGLEYLH--QHWILHRDLKPNNLLLDE-NGVLKLADFGLAK--S 161 + P IK ++ ++ + LH + HRD+KP+N+L++E +G LKL DFG AK S Sbjct: 124 VAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS 183 Query: 162 FGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 PN AY + +R+YRAPEL+FG + Y VD+W+VGCI AE++L P GD+ Q Sbjct: 184 PSEPNVAY---ICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQ 240 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS----AAGDDLLDLIQGLFL 277 L I LG P+ E + V + GIP ++FS + DL+ L Sbjct: 241 LHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQ 300 Query: 278 FNPCARITATQALKMKYFSNRPGPT 302 + P R+ +AL YF P Sbjct: 301 YLPEERMKPYEALCHPYFDELHDPA 325 >5AWM-A nrPDB Length = 394 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 102/322 (31%), Positives = 163/322 (50%), Gaps = 37/322 (11%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY L +G G V A D T Q VAIKK+ ++ + A RE KL++ ++ Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---AKRAYREFKLMKLVN 101 Query: 71 HPNIIGLLDAFGHKSN------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 H NIIGLL+AF + N + LV + M+ +L +I+ + L + + L G Sbjct: 102 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLCG 158 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 +++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ T VVTR+YRAPE++ Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGT-TFMMTPYVVTRYYRAPEVI 217 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-SL 243 G Y VD+W+VGCI+ E++ PG +DQ +I E LGTP+ + ++ Sbjct: 218 LGMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 276 Query: 244 PDYVTFK-SFPGIPLHHIF-------------SAAGDDLLDLIQGLFLFNPCARITATQA 289 +YV + + G +F D +L+ + + +P RI+ +A Sbjct: 277 RNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEA 336 Query: 290 LKMKYFS--------NRPGPTP 303 LK +Y + + P P P Sbjct: 337 LKHEYINVWYDAEEVDAPAPEP 358 >3E7O-A nrPDB Length = 360 Score = 144 bits (362), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 103/333 (30%), Positives = 172/333 (51%), Gaps = 29/333 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 KRY++L +G G V A D VA+KK+ +++ + A RE+ LL+ + Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTH---AKRAYRELVLLKCV 78 Query: 70 SHPNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 +H NII LL+ F + ++ LV + M+ +L +I + L + + L Sbjct: 79 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH---MELDHERMSYLLYQMLC 135 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ S N T VVTR+YRAPE+ Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-ASTNFMMTPYVVTRYYRAPEV 194 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-S 242 + G Y VD+W+VGCI+ EL+ G +DQ ++ E LGTP+ E + + Sbjct: 195 ILGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 243 LPDYVTFK-SFPGIPLHHIF------SAAGDDLL------DLIQGLFLFNPCARITATQA 289 + +YV + ++PGI +F S + D + DL+ + + +P RI+ +A Sbjct: 254 VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEA 313 Query: 290 LKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSN 322 L+ Y + P + P P L+E+ + Sbjct: 314 LRHPYITVWYDPAEA-EAPPPQIYDAQLEEREH 345 >1JNK-A nrPDB Length = 423 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 95/307 (30%), Positives = 162/307 (52%), Gaps = 28/307 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 KRY+ L +G G V A D ++ VAIKK+ +++ + A RE+ L++ + Sbjct: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH---AKRAYRELVLMKCV 118 Query: 70 SHPNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 +H NII LL+ F + ++ LV + M+ +L +I+ + L + + L Sbjct: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLC 175 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ + T VVTR+YRAPE+ Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-SFMMTPYVVTRYYRAPEV 234 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-S 242 + G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + + Sbjct: 235 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 243 LPDYVTFK------SFPGIPLHHIFSAAGD-------DLLDLIQGLFLFNPCARITATQA 289 + +YV + +FP + +F A + DL+ + + +P RI+ A Sbjct: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 Query: 290 LKMKYFS 296 L+ Y + Sbjct: 354 LQHPYIN 360 >2XS0-A nrPDB Length = 386 Score = 141 bits (356), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 99/335 (29%), Positives = 168/335 (50%), Gaps = 33/335 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 KRY+ L +G G V A D + VAIKK+ +++ + A RE+ L++ + Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTH---AKRAYRELVLMKCV 82 Query: 70 SHPNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 +H NIIGLL+ F + ++ +V + M+ +L +I+ + L + + L Sbjct: 83 NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ---MELDHERMSYLLYQMLC 139 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ + VVTR+YRAPE+ Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-SFMMVPFVVTRYYRAPEV 198 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-- 241 + G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + Sbjct: 199 ILGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 242 ------SLPDYVTFKS--------FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287 + P Y + FP H+ A+ DL+ + + + RI+ Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKAS--QARDLLSKMLVIDASKRISVD 315 Query: 288 QALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSN 322 +AL+ Y + P+ + P P P + L E+ + Sbjct: 316 EALQHPYINVWYDPSEA-EAPPPKIPDKQLDEREH 349 >3FI2-A nrPDB Length = 353 Score = 141 bits (355), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 95/307 (30%), Positives = 162/307 (52%), Gaps = 28/307 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 KRY+ L +G G V A D ++ VAIKK+ +++ + A RE+ L++ + Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH---AKRAYRELVLMKCV 80 Query: 70 SHPNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 +H NII LL+ F + ++ LV + M+ +L +I+ + L + + L Sbjct: 81 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQMLC 137 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ + T VVTR+YRAPE+ Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGT-SFMMTPYVVTRYYRAPEV 196 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC-S 242 + G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + + Sbjct: 197 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 243 LPDYVTFK------SFPGIPLHHIFSAAGD-------DLLDLIQGLFLFNPCARITATQA 289 + +YV + +FP + +F A + DL+ + + +P RI+ A Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 290 LKMKYFS 296 L+ Y + Sbjct: 316 LQHPYIN 322 >5Y86-A nrPDB Length = 588 Score = 140 bits (353), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 108/365 (29%), Positives = 174/365 (47%), Gaps = 66/365 (18%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A RYE L +G+G F V + D Q VA+K + R+E + +R A EI++L+ Sbjct: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV----RNEKR--FHRQAAEEIRILEH 259 Query: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMT 121 L N+I +L++F ++++ + F+ + DL +IK N + ++ + Sbjct: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 LQ L+ LH++ I+H DLKP N+LL +G K+ DFG S + YT+ + +R+YR Sbjct: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG--SSCFEYQKLYTY-IQSRFYR 376 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE++ G+R Y +D+W+ GCILAELL P PG+ + DQL + E LG P + Sbjct: 377 APEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQG------------------------- 274 ++ K GIP + + D + L+ G Sbjct: 436 SKRAKYFINSK---GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492 Query: 275 -LFL--------FNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETL--KEQSNP 323 LF+ ++P AR+T QAL+ + S +PRP ++ + K NP Sbjct: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISK--------SVPRPLTTIDKVSGKRVVNP 544 Query: 324 ALAIK 328 A A + Sbjct: 545 ASAFQ 549 >6O6Q-A nrPDB Length = 335 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 94/299 (31%), Positives = 154/299 (51%), Gaps = 29/299 (9%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70 YE L LG G+++ V+ D + V IK +K R + K REI +L+ L Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIK--------REISILKNLVD 94 Query: 71 HPNIIGLLDAFGHKSNIS--LVFDFMETDLEVIIKDNSL--VLTPSHIKAYMLMTLQGLE 126 PNII +LD + + L+F+ + I SL T I+ YM L+ L+ Sbjct: 95 GPNIIAMLDVVREPQSKTPGLIFEHINN-----IDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 127 YLHQHWILHRDLKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y H I+HRD+KP+N+++D + +L+L D+GLA+ + P Y +V +R+++ PELL Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYY-HPGTEYNVRVASRYFKGPELLV 208 Query: 186 GARMYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 R+Y +DMW+ GC+LA ++ ++ PF G S+ DQL +I LG+ +++ + ++ Sbjct: 209 DYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNIS 268 Query: 245 ---DYVTFKSFPGIPLHHIFSAAGDDL-----LDLIQGLFLFNPCARITATQALKMKYF 295 +Y + + DL LDLI L ++ R+TA +A+K YF Sbjct: 269 LGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >3EB0-A nrPDB Length = 383 Score = 131 bits (330), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 92/336 (27%), Positives = 157/336 (46%), Gaps = 57/336 (16%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 +++ +K+Y LG G F V + D + + A+KK+ R + RE+ Sbjct: 2 LETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN---------RELD 52 Query: 65 LLQELSHPNIIGLLDAF--------------------GHKSN------------------ 86 +++ L H NII L+D F G K+N Sbjct: 53 IMKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKY 112 Query: 87 ISLVFDFMETDLEVIIKD---NSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNL 143 ++++ +++ L ++K + + + I Y+ + + ++H I HRD+KP NL Sbjct: 113 LNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNL 172 Query: 144 LLD-ENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVG 200 L++ ++ LKL DFG AK P+ AY + +R+YRAPEL+ GA Y +D+W++G Sbjct: 173 LVNSKDNTLKLCDFGSAKKLIPSEPSVAY---ICSRFYRAPELMLGATEYTPSIDLWSIG 229 Query: 201 CILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHI 260 C+ EL+L P G++ +DQL RI + +GTPT+EQ M V F + I Sbjct: 230 CVFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKI 289 Query: 261 FSAAGDDL-LDLIQGLFLFNPCARITATQALKMKYF 295 L +DL++ + + P RI +A+ +F Sbjct: 290 LPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >3NCG-A nrPDB Length = 486 Score = 130 bits (327), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 102/326 (31%), Positives = 155/326 (47%), Gaps = 41/326 (12%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A+RY + LG+G F V K +D+ T Q A+K I +++ AK+ T LRE++LL++ Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVI---NKASAKNKDTSTILREVELLKK 77 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYML-MTLQGL 125 L HPNI+ L + S+ +V + + IIK H A ++ G+ Sbjct: 78 LDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRF---SEHDAARIIKQVFSGI 134 Query: 126 EYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Y+H+H I+HRDLKP N+LL +++ +K+ DFGL+ F N ++ T +Y APE Sbjct: 135 TYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCF-QQNTKMKDRIGTAYYIAPE 193 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L G Y D+W+ G IL LL P G ++ D L R+ E Sbjct: 194 VLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV---------ETGKYAFD 242 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 LP + T DD DLI+ + F+P RITATQ L+ + T Sbjct: 243 LPQWRTI---------------SDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSET 287 Query: 303 PG-CQLPRPNCPVETLKE-QSNPALA 326 P LP + +++ Q+ LA Sbjct: 288 PTISDLPSLESAMTNIRQFQAEKKLA 313 >3DFA-A nrPDB Length = 286 Score = 127 bits (318), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 95/289 (32%), Positives = 142/289 (49%), Gaps = 39/289 (13%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A+RY + LG+G F V K +D+ T Q A+K I +++ AK+ T LRE++LL++ Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVI---NKASAKNKDTSTILREVELLKK 77 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYML-MTLQGL 125 L HPNI+ L + S+ +V + + IIK H A ++ G+ Sbjct: 78 LDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRF---SEHDAARIIKQVFSGI 134 Query: 126 EYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Y+H+H I+HRDLKP N+LL +++ +K+ DFGL+ F N ++ T +Y APE Sbjct: 135 TYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCF-QQNTKMKDRIGTAYYIAPE 193 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L G Y D+W+ G IL LL P G ++ D L R+ E Sbjct: 194 VLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV---------ETGKYAFD 242 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 LP + T DD DLI+ + F+P RITATQ L+ Sbjct: 243 LPQWRTI---------------SDDAKDLIRKMLTFHPSLRITATQCLE 276 >5XVU-A nrPDB Length = 332 Score = 125 bits (314), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 90/303 (29%), Positives = 155/303 (51%), Gaps = 26/303 (8%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 ++ RYE + +G G+++ V+ D N+ A K + REIK+L Sbjct: 28 NKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA--------IKVLKPVKKKKIKREIKIL 79 Query: 67 QELSH-PNIIGLLDAFGH--KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Q L+ PNII LLD SL+F+++ + K T I+ Y+ L+ Sbjct: 80 QNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINN---IDFKTLYPKFTDKDIRYYIYQILK 136 Query: 124 GLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 L+Y H I+HRD+KP+N+++D EN ++L +GLA+ F P + Y +V +R+Y+ PE Sbjct: 137 ALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAE-FYHPGQEYNVRVASRYYKGPE 195 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 LL ++Y +D+W++GC+LA ++ + PF G + DQL +I + LGT + Sbjct: 196 LLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKY 255 Query: 242 SL---PDYVT-FKSFPGIPLHHIFSA-----AGDDLLDLIQGLFLFNPCARITATQALKM 292 ++ P Y+ + P H + A D+++DLI + +++ RI +A++ Sbjct: 256 NIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 Query: 293 KYF 295 YF Sbjct: 316 PYF 318 >4LFI-A nrPDB Length = 374 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 81/242 (33%), Positives = 132/242 (54%), Gaps = 23/242 (9%) Query: 71 HPNIIGLLDAFGHKSNIS----LVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 H NII L D K IS LVF++++ D ++ LT I+ YM L+ L Sbjct: 132 HANIIHLFDII--KDPISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKAL 185 Query: 126 EYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 +Y H I+HRD+KP+N+++D +N L+L D+GLA+ F N Y +V +R+++ PELL Sbjct: 186 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAE-FYHVNMEYNVRVASRFFKGPELL 244 Query: 185 FGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQW--PDMC 241 RMY +D+W+ G +LA ++ R PF G S+ DQL +I + LGT E++ Sbjct: 245 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 304 Query: 242 SLP-DYVTFKSFPGIPLHHIFS------AAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 +LP ++ + P H + + D+++DLI L ++ R+TA +A+ + Sbjct: 305 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 364 Query: 295 FS 296 F+ Sbjct: 365 FA 366 >6HMD-A nrPDB Length = 365 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 77/240 (32%), Positives = 128/240 (53%), Gaps = 25/240 (10%) Query: 73 NIIGLLDAFGH--KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 NII L+D +LVF+++ TD + + + +LT I+ YM L+ L+Y H Sbjct: 109 NIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDYCH 164 Query: 130 QHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 I+HRD+KP+N+++D + L+L D+GLA+ F P + Y +V +R+++ PELL + Sbjct: 165 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVDYQ 223 Query: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPT------------EE 235 MY +DMW++GC+LA ++ R PF G + DQL RI + LGT + Sbjct: 224 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 283 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + D+ +++F H+ S LDL+ L ++ R+TA +A++ YF Sbjct: 284 HFNDILGQHSRKRWENFIHSENRHLVSPEA---LDLLDKLLRYDHQQRLTAKEAMEHPYF 340 >6EII-A nrPDB Length = 352 Score = 117 bits (293), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 80/243 (32%), Positives = 129/243 (53%), Gaps = 29/243 (11%) Query: 72 PNIIGLLDAFGHKSNIS----LVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 PNII L D K +S LVF+ + TD + + + LT I+ YM L+ L+ Sbjct: 115 PNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 168 Query: 127 YLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y H I+HRD+KP+N+++D E+ L+L D+GLA+ F P + Y +V +R+++ PELL Sbjct: 169 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 227 Query: 186 GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPT----------- 233 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT Sbjct: 228 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 287 Query: 234 -EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 + ++ D+ ++ F H+ S LD + L ++ +R+TA +A++ Sbjct: 288 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEA---LDFLDKLLRYDHQSRLTAREAMEH 344 Query: 293 KYF 295 YF Sbjct: 345 PYF 347 >4MD7-E nrPDB Length = 391 Score = 117 bits (293), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 80/243 (32%), Positives = 130/243 (53%), Gaps = 29/243 (11%) Query: 72 PNIIGLLDAFGHKSNIS----LVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 PNII L D K +S LVF+ + TD + + + LT I+ YM L+ L+ Sbjct: 92 PNIITLADIV--KDPVSRTPALVFEHVNNTDFKQLYQ----TLTDYDIRFYMYEILKALD 145 Query: 127 YLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y H I+HRD+KP+N+++D E+ L+L D+GLA+ F P + Y +V +R+++ PELL Sbjct: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204 Query: 186 GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPT----------- 233 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT Sbjct: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Query: 234 -EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 + ++ D+ ++ F H+ S + LD + L ++ +R+TA +A++ Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSP---EALDFLDKLLRYDHQSRLTAREAMEH 321 Query: 293 KYF 295 YF Sbjct: 322 PYF 324 >3LIJ-A nrPDB Length = 494 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 96/335 (28%), Positives = 150/335 (44%), Gaps = 66/335 (19%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++ Y+++ LG G + V RDK T+ AIK I+ ++ N L E+ +L+ Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIR---KTSVSTSSNSKLLEEVAVLKL 92 Query: 69 LSHPNIIGLLDAFGHKSNISLV---------FD-------FMETDLEVIIKDNSLVLTPS 112 L HPNI+ L D F K N LV FD F E D VIIK Sbjct: 93 LDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIK--------- 143 Query: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAY 169 L G+ YLH+H I+HRDLKP NLLL +++ ++K+ DFGL+ F + + Sbjct: 144 -------QVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKM- 195 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 ++ T +Y APE+L + Y D+W++G IL LL P G +D + L ++ + Sbjct: 196 KERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGK 253 Query: 230 GTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 T +W ++ + DLI+ + F+ RI+A QA Sbjct: 254 YTFDSPEWKNV------------------------SEGAKDLIKQMLQFDSQRRISAQQA 289 Query: 290 LKMKYFSNR-PGPTPGCQLPRPNCPVETLKEQSNP 323 L+ + G +LP +E +++ N Sbjct: 290 LEHPWIKEMCSKKESGIELPSLANAIENMRKFQNS 324 >3MN3-A nrPDB Length = 271 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 92/296 (31%), Positives = 143/296 (48%), Gaps = 56/296 (18%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LGEG F V A T Q VA+K I + AK + REI L+ L H Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKII--NKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P+II L D K I +V ++ +L + I++ + + + + + + +EY H+ Sbjct: 64 PHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKM--SEQEARRFFQQIISAVEYCHR 121 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRA 180 H I+HRDLKP NLLLDE+ +K+ADFGL+ S GSPN Y A Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPN-----------YAA 170 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 PE++ G G VD+W+ G IL +L R+PF D + + +F+ + Sbjct: 171 PEVISGKLYAGPEVDVWSCGVILYVMLCRRLPF-----DDESIPVLFKNISN-------G 218 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + +LP +++ PG AAG LI+ + + NP RI+ + ++ +F Sbjct: 219 VYTLPKFLS----PG--------AAG-----LIKRMLIVNPLNRISIHEIMQDDWF 257 >2PVN-A nrPDB Length = 352 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 88/302 (29%), Positives = 145/302 (48%), Gaps = 32/302 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 YE + +G G+++ V++ + N N+ K + + L Sbjct: 54 YEVVRKVGRGKYSEVFEGINVNNNE-------KCIIKILKPVKKKKIKREIKILQNLCGG 106 Query: 72 PNIIGLLDAF--GHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ LLD H SL+F+++ TD +V+ LT I+ Y+ L+ L+Y Sbjct: 107 PNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYP----TLTDYDIRYYIYELLKALDYC 162 Query: 129 HQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 H I+HRD+KP+N+++D E L+L D+GLA+ F P + Y +V +R+++ PELL Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAE-FYHPGKEYNVRVASRYFKGPELLVDL 221 Query: 188 RMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQW--------- 237 + Y +DMW++GC+ A ++ R PF G + DQL +I + LGT + Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 238 PDMCSLPDYVTFK---SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 P + +L + K F H+ S D LD L ++ R+TA +A+ Y Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLD---KLLRYDHQERLTALEAMTHPY 338 Query: 295 FS 296 F Sbjct: 339 FQ 340 >4MVF-A nrPDB Length = 506 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 87/281 (30%), Positives = 134/281 (47%), Gaps = 45/281 (16%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKD---GINRTALREIKLLQELSHPNI 74 LG+G + VYK DK TNQ+ AIK+ E KD INR +EI+++++L HPNI Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKE-------EKKDRLKNINR-FFQEIEIMKKLDHPNI 116 Query: 75 IGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 + L + + + + I L+ + + II++ S T + M + YLH Sbjct: 117 VKLYETYENDNYIYLIMELCSGRELFDSIIENGS--FTEKNAATIMKQIFSAIFYLHSLN 174 Query: 133 ILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 I+HRDLKP N L +++ +LK+ DFGL+K+ G+ T + T +Y AP++L G Sbjct: 175 IVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT-TTKAGTPYYVAPQVLDGK-- 231 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y D+W+ G I+ LL P GD+D + L ++ + E W + S Sbjct: 232 YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISS------- 284 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 D +LI L +NP R T +AL Sbjct: 285 -----------------DAKNLITKLLTYNPNERCTIEEAL 308 >2WQN-A nrPDB Length = 310 Score = 110 bits (276), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 74/242 (30%), Positives = 123/242 (50%), Gaps = 17/242 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G GQF+ VY+A VA+KK+++ +AK + ++EI LL++L+HPN+I Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARAD--CIKEIDLLKQLNHPNVIKY 97 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIK---DNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +F + +++V + + DL +IK ++ + Y + LE++H + Sbjct: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 +HRD+KP N+ + GV+KL D GL + F S A V T +Y +PE + Y Sbjct: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH-ENGYNFK 216 Query: 194 VDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFETLGTP-------TEE--QWPDMCSL 243 D+W++GC+L E+ L+ PF +L L + E P +EE Q +MC Sbjct: 217 SDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCIN 276 Query: 244 PD 245 PD Sbjct: 277 PD 278 >4IAN-A nrPDB Length = 358 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 72/219 (32%), Positives = 120/219 (54%), Gaps = 19/219 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 KRY + G+G F+ V +ARD NQ VA+K I+ + + +T L+E++ L++ Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR------NNELMQKTGLKELEFLKK 83 Query: 69 LSHPN------IIGLLDAFGHKSNISLVFDFMETDLEVIIKD--NSLVLTPSHIKAYMLM 120 L+ + + L F HK ++ LVF+ + +L ++K + L +++Y Sbjct: 84 LNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQ 143 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L+ L + ILH D+KP+N+L++E+ +LKL DFG A + T +V+R+YR Sbjct: 144 LFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYR 201 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 APE++ G + Y G+DMW+VGC L EL PG ++ Sbjct: 202 APEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTN 239 >3DXN-A nrPDB Length = 287 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 90/291 (30%), Positives = 139/291 (47%), Gaps = 44/291 (15%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQ 67 + RY+++ LG G + V +DK T AIK IK +S N AL E+ +L+ Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIK---KSSVTTTSNSGALLDEVAVLK 76 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLM--TL 122 +L HPNI+ L + F K N LV + E E+I++ S + A ++M L Sbjct: 77 QLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKF-----SEVDAAVIMKQVL 131 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 G YLH+H I+HRDLKP NLLL+ + ++K+ DFGL+ F + ++ T +Y Sbjct: 132 SGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYI 190 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L + Y D+W+ G IL LL P G +D + L R+ E+ Sbjct: 191 APEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV---------EKGKF 239 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 PD+ + D+ L++ + + P RI+A +AL Sbjct: 240 SFDPPDW---------------TQVSDEAKQLVKLMLTYEPSKRISAEEAL 275 >3MA6-A nrPDB Length = 298 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 85/288 (29%), Positives = 135/288 (46%), Gaps = 38/288 (13%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ LG+G F V +DK T Q A+K I + D + LRE++LL++ Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD--KESLLREVQLLKQ 88 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L HPNI+ L + F K LV + E E+I + + + I + L G+ Sbjct: 89 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARI---IRQVLSGI 145 Query: 126 EYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Y+H++ I+HRDLKP NLLL+ ++ +++ DFGL+ F ++ ++ T +Y APE Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPE 204 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L G Y D+W+ G IL LL P G ++ D L ++ + T QW + Sbjct: 205 VLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKV-- 260 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 + DLI+ + + P RI+A AL Sbjct: 261 ----------------------SESAKDLIRKMLTYVPSMRISARDAL 286 >5JN2-A nrPDB Length = 525 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 89/325 (27%), Positives = 147/325 (45%), Gaps = 39/325 (12%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ LG+G F V +DK T Q A+K I + D + LRE++LL++ Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD--KESLLREVQLLKQ 123 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L HPNI+ L + F K LV + E E+I + + + I + L G+ Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARI---IRQVLSGI 180 Query: 126 EYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Y+H++ I+HRDLKP NLLL+ ++ +++ DFGL+ F ++ ++ T +Y APE Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPE 239 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L G Y D+W+ G IL LL P G ++ D L ++ + T QW + Sbjct: 240 VLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVS- 296 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 + DLI+ + + P RI+A AL ++ Sbjct: 297 -----------------------ESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 333 Query: 303 PGCQLPRPNCPVETLKE-QSNPALA 326 +P + + +++ Q LA Sbjct: 334 ISVDVPSLDNAILNIRQFQGTQKLA 358 >4RGJ-A nrPDB Length = 520 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 85/292 (29%), Positives = 138/292 (47%), Gaps = 39/292 (13%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y+ + LG+G F V +RDK+T AIK I H D + LRE++LL+ L Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTD--KESLLREVELLKML 117 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 H NI+ L + F + LV D E E+I + + + I + L G+ Sbjct: 118 DHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARI---IKQILSGIT 174 Query: 127 YLHQHWILHRDLKPNNLLLD----ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Y+H++ ++HRDLKP N+LL+ E+ ++K+ DFGL+ F ++ ++ T +Y AP+ Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF-EYSKKMKDKIGTAYYIAPD 233 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L G Y D+W+ G IL LL P G ++ D L ++ E Sbjct: 234 VLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV---------EAGKYTFD 282 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 LP F D DLI+ + ++ RI+A AL+ ++ Sbjct: 283 LPQ---------------FKKISDKAKDLIKKMLMYTSAVRISARDALEHEW 319 >2J90-A nrPDB Length = 304 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 87/289 (30%), Positives = 134/289 (46%), Gaps = 33/289 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQELS 70 YE + LG GQFA V K R K T + A K IK S ++ G++R + RE+ +L+E+ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 87 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 HPNII L D F +K+++ L+ + + LT ++ L G+ YLH Sbjct: 88 HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 147 Query: 131 HWILHRDLKPNNLLLDENGV----LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I H DLKP N++L + V +KL DFG+A + N + + T + APE++ Sbjct: 148 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV-N 205 Query: 187 ARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G+ DMW++G I LL PFL G++ + LT I EE + + L Sbjct: 206 YEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAVNYDFDEEYFSNTSELAK 264 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 D I+ L + +P R+T Q+L+ + Sbjct: 265 ------------------------DFIRRLLVKDPKRRMTIAQSLEHSW 289 >3HZT-A nrPDB Length = 467 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 90/291 (30%), Positives = 139/291 (47%), Gaps = 44/291 (15%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQ 67 + RY+++ LG G + V +DK T AIK IK +S N AL E+ +L+ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIK---KSSVTTTSNSGALLDEVAVLK 59 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLM--TL 122 +L HPNI+ L + F K N LV + E E+I++ S + A ++M L Sbjct: 60 QLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKF-----SEVDAAVIMKQVL 114 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 G YLH+H I+HRDLKP NLLL+ + ++K+ DFGL+ F + ++ T +Y Sbjct: 115 SGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYI 173 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L + Y D+W+ G IL LL P G +D + L R+ E+ Sbjct: 174 APEVL--RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV---------EKGKF 222 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 PD+ + D+ L++ + + P RI+A +AL Sbjct: 223 SFDPPDW---------------TQVSDEAKQLVKLMLTYEPSKRISAEEAL 258 >2UV2-A nrPDB Length = 325 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 66/200 (33%), Positives = 107/200 (53%), Gaps = 10/200 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG+G F VYKA++K T+ + A K I E +D + EI +L H Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELED-----YMVEIDILASCDH 93 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 PNI+ LLDAF +++N+ ++ +F ++ ++ + LT S I+ TL L YLH Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA--- 187 + I+HRDLK N+L +G +KLADFG++ + + T ++ APE++ Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 188 -RMYGVGVDMWAVGCILAEL 206 R Y D+W++G L E+ Sbjct: 214 DRPYDYKADVWSLGITLIEM 233 >2Y7J-A nrPDB Length = 365 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 133/295 (45%), Gaps = 34/295 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRS---EAKDGINRTALREIKLL 66 ++Y+ D +G G + V + + T A+K +++ E + + RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 67 QELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 ++++ HP+II L+D++ S + LVFD M + L+ ++ M L+ + Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 +LH + I+HRDLKP N+LLD+N ++L+DFG + P T Y APE+L Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL-EPGEKLRELCGTPGYLAPEILK 272 Query: 186 GAR-----MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 + YG VD+WA G IL LL P + L I E + +W D Sbjct: 273 CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDR 332 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 S T K DLI L +P AR+TA QAL+ +F Sbjct: 333 SS-----TVK-------------------DLISRLLQVDPEARLTAEQALQHPFF 363 >4JXF-A nrPDB Length = 266 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 81/282 (28%), Positives = 132/282 (46%), Gaps = 32/282 (11%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG+G FA VY+A +T VAIK I ++ K G+ + E+K+ +L HP+I+ Sbjct: 13 NLLGKGSFAGVYRAESIHTGLEVAIKMID--KKAMYKAGMVQRVQNEVKIHCQLKHPSIL 70 Query: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + F + + LV + ++ +K+ + + + +M + G+ YLH H IL Sbjct: 71 ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGIL 130 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGV 194 HRDL +NLLL N +K+ADFGLA P+ + T Y +PE+ + +G+ Sbjct: 131 HRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS-AHGLES 189 Query: 195 DMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG 254 D+W++GC+ LL+ P D+ + L ++ L DY SF Sbjct: 190 DVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----------------LADY-EMPSFLS 232 Query: 255 IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 I + DLI L NP R++ + L + S Sbjct: 233 I-----------EAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >1U5R-A nrPDB Length = 348 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 70/205 (34%), Positives = 107/205 (52%), Gaps = 10/205 (4%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKL-GHRSEAKDGINRTALREIKLLQE 68 K + L +G G F VY ARD +++VAIKK+ G +S K + ++E++ LQ+ Sbjct: 54 KLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEK---WQDIIKEVRFLQK 110 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPN I + + LV ++ +++ + L I A LQGL YL Sbjct: 111 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 170 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H H ++HRD+K N+LL E G++KL DFG A S +P ++ V T ++ APE++ Sbjct: 171 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA-SIMAPANSF---VGTPYWMAPEVILAMD 226 Query: 189 --MYGVGVDMWAVGCILAELLLRVP 211 Y VD+W++G EL R P Sbjct: 227 EGQYDGKVDVWSLGITCIELAERKP 251 >3Q5I-A nrPDB Length = 504 Score = 105 bits (262), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 91/299 (30%), Positives = 133/299 (44%), Gaps = 42/299 (14%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKL-----GHRSEAKDGINR---TAL 60 + Y K+ LG G + V ++KN + AIK IK G S+ I + Sbjct: 35 GESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY 94 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYM 118 EI LL+ L HPNII L D F K LV +F E E II N M Sbjct: 95 NEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQII--NRHKFDECDAANIM 152 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVL---KLADFGLAKSFGSPNRAYTHQVVT 175 L G+ YLH+H I+HRD+KP N+LL+ L K+ DFGL+ SF S + ++ T Sbjct: 153 KQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLS-SFFSKDYKLRDRLGT 211 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 235 +Y APE+L + Y D+W+ G I+ LL P G +D D + ++ + Sbjct: 212 AYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKG------- 262 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 Y F + I D+ +LI+ + ++ R TA +AL ++ Sbjct: 263 --------KYYFDFNDWKNIS---------DEAKELIKLMLTYDYNKRCTAEEALNSRW 304 >2GCD-A nrPDB Length = 309 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 70/205 (34%), Positives = 107/205 (52%), Gaps = 10/205 (4%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKL-GHRSEAKDGINRTALREIKLLQE 68 K + L +G G F VY ARD +++VAIKK+ G +S K + ++E++ LQ+ Sbjct: 15 KLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEK---WQDIIKEVRFLQK 71 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPN I + + LV ++ +++ + L I A LQGL YL Sbjct: 72 LRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYL 131 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H H ++HRD+K N+LL E G++KL DFG A S +P ++ V T ++ APE++ Sbjct: 132 HSHNMIHRDVKAGNILLSEPGLVKLGDFGSA-SIMAPANSF---VGTPYWMAPEVILAMD 187 Query: 189 --MYGVGVDMWAVGCILAELLLRVP 211 Y VD+W++G EL R P Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKP 212 >4I6B-A nrPDB Length = 308 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 67/205 (32%), Positives = 102/205 (49%), Gaps = 4/205 (1%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 KRY + LG+G FA Y+ D N++ A K I H +K +EI+L + Sbjct: 27 GKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIP--HSRVSKPHQREKIDKEIELHRI 84 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L H +++ F K NI ++ ++ I VLT ++ Y+ + GL+YL Sbjct: 85 LHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYL 144 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H+ ILHRDLK N ++E+ LK+ DFGLA T Y +PE+L + Sbjct: 145 HEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQ 203 Query: 189 MYGVGVDMWAVGCILAELLL-RVPF 212 +G D+WA+GC++ +LL R PF Sbjct: 204 GHGAESDIWALGCVMYTMLLGRPPF 228 >3COM-A nrPDB Length = 314 Score = 104 bits (259), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 86/327 (26%), Positives = 151/327 (46%), Gaps = 47/327 (14%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 ++ L+ LGEG + +VYKA K T QIVAIK++ + S+ ++ I +EI ++Q+ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV--ESDLQEII-----KEISIMQQCDS 83 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P+++ ++ +++ +V ++ + II+ + LT I + TL+GLEYLH Sbjct: 84 PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 +HRD+K N+LL+ G KLADFG+A + T ++ APE++ Y Sbjct: 144 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGY 202 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 D+W++G E+ P +D+ + IF P P P+ + Sbjct: 203 NCVADIWSLGITAIEM---AEGKPPYADIHPMRAIFMIPTNP-----PPTFRKPELWS-- 252 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRP 310 D+ D ++ + +P R TATQ L+ + + G Sbjct: 253 ---------------DNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG---------- 287 Query: 311 NCPVETLKEQSNPALAIKRKRTEALEQ 337 V L++ N A+ +K KR E+ ++ Sbjct: 288 ---VSILRDLINEAMDVKLKRQESQQR 311 >4B6L-A nrPDB Length = 281 Score = 103 bits (258), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 71/204 (34%), Positives = 98/204 (48%), Gaps = 5/204 (2%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + Y K LG+G FA Y+A D T A+K I AK L EI+L ++ Sbjct: 8 GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIP--QSRVAKPHQREKILNEIELHRD 65 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 L H +I+ F NI + + L I K +L P ++ Y+ L GL+Y Sbjct: 66 LQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE-VRYYLRQILSGLKY 124 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 LHQ ILHRDLK N + EN LK+ DFGLA P + T Y APE+L Sbjct: 125 LHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-R 183 Query: 188 RMYGVGVDMWAVGCILAELLLRVP 211 + +G D+W++GC++ LL P Sbjct: 184 QGHGPEADVWSLGCVMYTLLCGSP 207 >3H4J-B nrPDB Length = 336 Score = 103 bits (258), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 27/207 (13%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LGEG F V A T Q VA+K I + K ++ REI L+ L HP+II L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFI--SRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 78 LDAFGHKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 D ++I +V ++ +L + I++ + T + + + +EY H+H I+HR Sbjct: 75 YDVITTPTDIVMVIEYAGGELFDYIVEKKRM--TEDEGRRFFQQIICAIEYCHRHKIVHR 132 Query: 137 DLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRAPELLFG 186 DLKP NLLLD+N +K+ADFGL+ S GSPN Y APE++ G Sbjct: 133 DLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPN-----------YAAPEVING 181 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPF 212 G VD+W+ G +L +L+ R+PF Sbjct: 182 KLYAGPEVDVWSCGIVLYVMLVGRLPF 208 >3Q53-A nrPDB Length = 306 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 123/234 (52%), Gaps = 11/234 (4%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K+Y + + +G+G TVY A D T Q VAI+++ L + + + IN EI +++E Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIIN-----EILVMREN 75 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 +PNI+ LD++ + +V +++ L ++ + + I A LQ LE+L Sbjct: 76 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECLQALEFL 133 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H + ++HRD+K +N+LL +G +KL DFG + V T ++ APE++ + Sbjct: 134 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRK 192 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 YG VD+W++G + E++ P ++ L L + T GTP E Q P+ S Sbjct: 193 AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRAL-YLIATNGTP-ELQNPEKLS 244 >4CZT-A nrPDB Length = 464 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/238 (32%), Positives = 114/238 (47%), Gaps = 32/238 (13%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++R +YE LGEG FA V AR+ VAIK I K+ + REI Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVID--KEKVLKNKMIAQIKREIST 64 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQG 124 ++ + HPN+I + + K+ I V +F+ T E+ K +S L + Y + Sbjct: 65 MKLIKHPNVIRMFEVMASKTKIYFVLEFV-TGGELFDKISSNGRLKEDEARKYFQQLINA 123 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA-------------KSFGSPNRAYTH 171 ++Y H + HRDLKP NLLLD NG LK++DFGL+ + G+PN Sbjct: 124 VDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN----- 178 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLP-GDSDLDQL-TRIFE 227 Y APE++ G D+W+ G IL +L +LP DS+L L +IF+ Sbjct: 179 ------YVAPEVINNKGYDGAKADLWSCGVIL--FVLMAGYLPFEDSNLTSLYKKIFK 228 >4APC-A nrPDB Length = 350 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 74/291 (25%), Positives = 128/291 (43%), Gaps = 33/291 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y +L +GEG F + + IK+I + S + +R RE+ +L + Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESR---REVAVLANM 80 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 HPNI+ ++F ++ +V D+ E + I ++ I + + L++ Sbjct: 81 KHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKH 140 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 +H ILHRD+K N+ L ++G ++L DFG+A+ S + T +Y +PE+ Sbjct: 141 VHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEIC-EN 199 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 + Y D+WA+GC+L EL L FE M +L + Sbjct: 200 KPYNNKSDIWALGCVLYELC-------------TLKHAFEA---------GSMKNLVLKI 237 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 SFP + LH+ + DL L+ LF NP R + L+ + + R Sbjct: 238 ISGSFPPVSLHYSY-----DLRSLVSQLFKRNPRDRPSVNSILEKGFIAKR 283 >6FD3-A nrPDB Length = 300 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 73/244 (29%), Positives = 126/244 (51%), Gaps = 15/244 (6%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K+Y + + +G+G TVY A D T Q VAIK++ L + + + IN EI +++E Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN-----EILVMREN 76 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 +PNI+ LD++ + +V +++ L ++ + + I A LQ L++L Sbjct: 77 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECLQALDFL 134 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H + ++HRD+K +N+LL +G +KL DFG + V T ++ APE++ + Sbjct: 135 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRK 193 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 YG VD+W++G + E++ P ++ L L + T GTP E Q P+ S Sbjct: 194 AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTP-ELQNPERLS----AV 247 Query: 249 FKSF 252 F+ F Sbjct: 248 FRDF 251 >1S9I-A nrPDB Length = 354 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 78/235 (33%), Positives = 119/235 (50%), Gaps = 15/235 (6%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E++ LG G V K + + + I+A K I L E K I +RE+++L E + Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIHL----EIKPAIRNQIIRELQVLHECNS 73 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM-LMTLQGLEYLH 129 P I+G AF IS+ + M+ L+ ++K+ + P I + + L+GL YL Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI--PEEILGKVSIAVLRGLAYLR 131 Query: 130 Q-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y APE L G Sbjct: 132 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMAPERLQGTH 189 Query: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 Y V D+W++G L EL + R P P D+ +L IF EE P S Sbjct: 190 -YSVQSDIWSMGLSLVELAVGRYPIPPPDA--KELEAIFGRPVVDGEEGEPHSIS 241 >4UZD-A nrPDB Length = 287 Score = 102 bits (253), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 126/294 (42%), Gaps = 43/294 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G+F VY AR+K + I+A+K + +A G+ RE+++ L HPNI+ L Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA--GVEHQLRREVEIQSHLRHPNILRL 73 Query: 78 LDAFGHKSNISLVFDF-----METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 F + + L+ ++ + +L+ + K Y+ L Y H Sbjct: 74 YGYFHDATRVYLILEYAPLGTVYRELQKLSK-----FDEQRTATYITELANALSYCHSKR 128 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 ++HRD+KP NLLL G LK+ADFG S +P+ T T Y PE++ G RM+ Sbjct: 129 VIHRDIKPENLLLGSAGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIEG-RMHDE 185 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 VD+W++G + E L+ P ++ + RI T PD+VT Sbjct: 186 KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFT-----------FPDFVT---- 230 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 + DLI L NP R + L+ + + CQ Sbjct: 231 -------------EGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQ 271 >4D28-A nrPDB Length = 446 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 76/231 (32%), Positives = 112/231 (48%), Gaps = 31/231 (13%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 R +YE +GEG FA V AR+ +T VAIK + + K+ + REI +++ Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKI--MAKSTILKNRMVDQIKREISIMK 64 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 + HPNI+ L + KS I +V +F+ + I+ L S + Y + + Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDES--RKYFQQLVDAV 122 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK-----------SFGSPNRAYTHQVV 174 + H + HRDLKP NLLLD NG LK++DFGL+ + G+PN Sbjct: 123 AHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPN-------- 174 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLP-GDSDLDQLTR 224 Y APE+L G G D+W+ G IL +L +LP ++DL L R Sbjct: 175 ---YVAPEVLSGQGYDGSAADIWSCGVILFVIL--AGYLPFSETDLPGLYR 220 >2WO6-A nrPDB Length = 382 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 71/233 (30%), Positives = 126/233 (54%), Gaps = 21/233 (9%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RYE +G+G F V KA D+ + VAIK IK K +N+ + E++LL+ ++ Sbjct: 55 RYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIK-----NKKAFLNQAQI-EVRLLELMN 108 Query: 71 HPN------IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMTLQ 123 + I+ L F ++++ LVF+ + +L ++++ + ++ + + + Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCT 168 Query: 124 GLEYLH--QHWILHRDLKPNNLLL--DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L +L + I+H DLKP N+LL + +K+ DFG + G R Y + + +R+YR Sbjct: 169 ALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ--RIYQY-IQSRFYR 225 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 +PE+L G Y + +DMW++GCIL E+ P G +++DQ+ +I E LG P Sbjct: 226 SPEVLLGMP-YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIP 277 >5KKR-C nrPDB Length = 395 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 110/210 (52%), Gaps = 13/210 (6%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +EK+ LG G V+K K + ++A K I L E K I +RE+++L E + Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQVLHECNS 125 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM-LMTLQGLEYLH 129 P I+G AF IS+ + M+ L+ ++K + P I + + ++GL YL Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGLTYLR 183 Query: 130 Q-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L G Sbjct: 184 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTH 241 Query: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDS 217 Y V D+W++G L E+ + R P P D+ Sbjct: 242 -YSVQSDIWSMGLSLVEMAVGRYPIPPPDA 270 >4FG9-A nrPDB Length = 320 Score = 100 bits (249), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 83/290 (28%), Positives = 125/290 (43%), Gaps = 37/290 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ D LG G F+ V A DK T ++VAIK I EA +G + EI +L ++ H Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIA----KEALEGKEGSMENEIAVLHKIKH 75 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 PNI+ L D + ++ L+ + + I++ T + L ++YLH Sbjct: 76 PNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKG--FYTERDASRLIFQVLDAVKYLH 133 Query: 130 QHWILHRDLKPNNLL---LDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I+HRDLKP NLL LDE+ + ++DFGL+K P + T Y APE+L Sbjct: 134 DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-A 191 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 + Y VD W++G I LL P ++D +I + W D+ Sbjct: 192 QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDI------ 245 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 D D I+ L +P R T QAL+ + + Sbjct: 246 ------------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >3D2K-A nrPDB Length = 272 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 82/291 (28%), Positives = 130/291 (44%), Gaps = 46/291 (15%) Query: 18 LGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 LG+G+F VY AR++ + I+A+K K +L K G+ RE+++ L HPNI Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQL-----EKAGVEHQLRREVEIQSHLRHPNI 74 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLEYLHQHW 132 + L F + + L+ ++ L + ++ + Y+ L Y H Sbjct: 75 LRLYGYFHDATRVYLILEY--APLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKR 132 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 ++HRD+KP NLLL NG LK+ADFG S +P+ T T Y PE++ G RM+ Sbjct: 133 VIHRDIKPENLLLGSNGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIEG-RMHDE 189 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 VD+W++G + E L+ +P + + RI T PD+VT Sbjct: 190 KVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFT-----------FPDFVT---- 234 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK---MKYFSNRPG 300 + DLI L N R+T + L+ +K S++P Sbjct: 235 -------------EGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPS 272 >6FYV-A nrPDB Length = 337 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 89/329 (27%), Positives = 141/329 (42%), Gaps = 55/329 (16%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQI-VAIKKIK-LGHRSEAKDGINRTALREIKLLQE 68 RYE +D LGEG F V + D + + VA+K +K +G EA A EI++L+ Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA-------ARSEIQVLEH 67 Query: 69 L--SHPN----IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMT 121 L + PN + +L+ F H ++ +VF+ + IK+NS + HI+ Sbjct: 68 LNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQI 127 Query: 122 LQGLEYLHQHWILHRDLKPNNLLL---------------DE----NGVLKLADFGLAKSF 162 Q + +LH + + H DLKP N+L DE N +K+ DFG A Sbjct: 128 CQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT-- 185 Query: 163 GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL 222 + ++ V TR YRAPE++ A + D+W++GCIL E L + L Sbjct: 186 -YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHL 243 Query: 223 TRIFETLG----------------TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGD 266 + LG + W + S YV + P + Sbjct: 244 AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHE 303 Query: 267 DLLDLIQGLFLFNPCARITATQALKMKYF 295 L DL++ + ++P RIT +AL+ +F Sbjct: 304 KLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >3TAC-A nrPDB Length = 361 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/294 (27%), Positives = 133/294 (45%), Gaps = 33/294 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 YE + +G+G F+ V + ++ T Q A+K + + + + RE + L H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 72 PNIIGLLDAFGHKSNISLVFDFME-TDL--EVIIK-DNSLVLTPSHIKAYMLMTLQGLEY 127 P+I+ LL+ + + +VF+FM+ DL E++ + D V + + YM L+ L Y Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 128 LHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 H + I+HRD+KP+ +LL + + +KL FG+A G +V T + APE++ Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV 207 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 YG VD+W G IL LL G + R+FE + + P S Sbjct: 208 -KREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIKGKYKMNPRQWS-- 259 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 HI +A DL++ + + +P RIT +AL + R Sbjct: 260 --------------HISESAK----DLVRRMLMLDPAERITVYEALNHPWLKER 295 >3EQC-A nrPDB Length = 360 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 110/210 (52%), Gaps = 13/210 (6%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +EK+ LG G V+K K + ++A K I L E K I +RE+++L E + Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQVLHECNS 90 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM-LMTLQGLEYLH 129 P I+G AF IS+ + M+ L+ ++K + P I + + ++GL YL Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGLTYLR 148 Query: 130 Q-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L G Sbjct: 149 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERLQGTH 206 Query: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDS 217 Y V D+W++G L E+ + R P P D+ Sbjct: 207 -YSVQSDIWSMGLSLVEMAVGRYPIPPPDA 235 >4LG4-A nrPDB Length = 299 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 82/321 (25%), Positives = 144/321 (44%), Gaps = 47/321 (14%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 ++ L+ LGEG + +V+KA K + Q+VAIK++ + S+ ++ ++EI ++Q+ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV--ESDLQE-----IIKEISIMQQCDS 65 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P ++ ++ +++ +V ++ + II+ + L I + TL+GLEYLH Sbjct: 66 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 +HR++K N+LL+ G KLADFG+A + T ++ APE++ Y Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGY 184 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 D+W++G E+ P +D+ + IF P P P+ + Sbjct: 185 NCVADIWSLGITSIEM---AEGKPPYADIHPMRAIFMIPTNP-----PPTFRKPELWS-- 234 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRP 310 DD D ++ + NP R TATQ L+ + N Sbjct: 235 ---------------DDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK----------- 268 Query: 311 NCPVETLKEQSNPALAIKRKR 331 PV L++ A+ IK KR Sbjct: 269 --PVSILRDLITEAMEIKAKR 287 >5X8I-B nrPDB Length = 346 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 92/330 (27%), Positives = 141/330 (42%), Gaps = 53/330 (16%) Query: 9 AKRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + RYE +D LGEG F V + D K + VA+K +K D A EI++L+ Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK------NVDRYCEAARSEIQVLE 65 Query: 68 EL--SHPN----IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLM 120 L + PN + +L+ F H +I +VF+ + IK+N + HI+ Sbjct: 66 HLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQ 125 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLL---------------DE----NGVLKLADFGLAKS 161 + + +LH + + H DLKP N+L DE N +K+ DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSAT- 184 Query: 162 FGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 + ++ V TR YRAPE++ A + D+W++GCIL E L P + Sbjct: 185 --YDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 222 LTRIFETLG-------TPTEEQ---------WPDMCSLPDYVTFKSFPGIPLHHIFSAAG 265 L + LG T ++ W + S YV+ P Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 266 DDLLDLIQGLFLFNPCARITATQALKMKYF 295 + L DLIQ + ++P RIT +ALK +F Sbjct: 302 ERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4AN9-A nrPDB Length = 301 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 77/245 (31%), Positives = 120/245 (48%), Gaps = 21/245 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +EK+ LG G V+K K + ++A K I L E K I +RE+++L E + Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQVLHECNS 66 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM-LMTLQGLEYLH 129 P I+G AF IS+ + M+ L+ ++K + P I + + ++GL YL Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI--PEQILGKVSIAVIKGLTYLR 124 Query: 130 Q-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L G Sbjct: 125 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDEMANEFVGTRSYMSPERLQGTH 182 Query: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 Y V D+W++G L E+ + R P P IFE L E P + S + Sbjct: 183 -YSVQSDIWSMGLSLVEMAVGRYPRPP--------MAIFELLDYIVNEPPPKLPSAVFSL 233 Query: 248 TFKSF 252 F+ F Sbjct: 234 EFQDF 238 >2YCR-A nrPDB Length = 323 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 85/292 (29%), Positives = 137/292 (46%), Gaps = 41/292 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIK-----KIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LG G V A ++ T + VAIK K +G EA +N EI++L++L+HP Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET--EIEILKKLNHP 75 Query: 73 NIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 II + + F + + +V + ME + ++ + L + K Y L ++YLH+ Sbjct: 76 CIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRL--KEATCKLYFYQMLLAVQYLHE 132 Query: 131 HWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL--F 185 + I+HRDLKP N+LL +E+ ++K+ DFG +K G + T T Y APE+L Sbjct: 133 NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYLAPEVLVSV 191 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G Y VD W++G IL L G P + SL D Sbjct: 192 GTAGYNRAVDCWSLGVILFICL---------------------SGYPPFSEHRTQVSLKD 230 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 +T + IP +++ + LDL++ L + +P AR T +AL+ + + Sbjct: 231 QITSGKYNFIP--EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >6AO5-A nrPDB Length = 362 Score = 98.6 bits (244), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 83/321 (25%), Positives = 144/321 (44%), Gaps = 47/321 (14%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 ++ L+ LGEG + +V+KA K + Q+VAIK++ + S+ ++ I +EI ++Q+ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV--ESDLQEII-----KEISIMQQCDS 64 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P ++ ++ +++ +V ++ + II+ + L I + TL+GLEYLH Sbjct: 65 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 +HR++K N+LL+ G KLADFG+A + T ++ APE++ Y Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGY 183 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 D+W++G E+ P +D+ + IF P P P+ + Sbjct: 184 NCVADIWSLGITSIEM---AEGKPPYADIHPMRAIFMIPTNP-----PPTFRKPELWS-- 233 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRP 310 DD D ++ + NP R TATQ L+ + N Sbjct: 234 ---------------DDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK----------- 267 Query: 311 NCPVETLKEQSNPALAIKRKR 331 PV L++ A+ IK KR Sbjct: 268 --PVSILRDLITEAMEIKAKR 286 >1KOA-A nrPDB Length = 491 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 83/302 (27%), Positives = 136/302 (45%), Gaps = 38/302 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG G F V++ ++ T A K + H S+ + T +EI+ + L H Sbjct: 53 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKE-----TVRKEIQTMSVLRH 107 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P ++ L DAF + + ++++FM +L + D ++ YM +GL ++H+ Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 167 Query: 131 HWILHRDLKPNNLLL--DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + +H DLKP N++ + LKL DFGL P ++ T + APE+ G + Sbjct: 168 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPEVAEG-K 225 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 G DMW+VG + LL + G++D ETL W ++ D Sbjct: 226 PVGYYTDMWSVGVLSYILLSGLSPFGGENDD-------ETLRNVKSCDW----NMDDSA- 273 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG--CQ 306 FS +D D I+ L L +P R+T QAL+ + + PG PG Q Sbjct: 274 ------------FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT--PGNAPGRDSQ 319 Query: 307 LP 308 +P Sbjct: 320 IP 321 >3UTO-A nrPDB Length = 573 Score = 98.2 bits (243), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 83/302 (27%), Positives = 136/302 (45%), Gaps = 38/302 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG G F V++ ++ T A K + H S+ + T +EI+ + L H Sbjct: 159 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKE-----TVRKEIQTMSVLRH 213 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P ++ L DAF + + ++++FM +L + D ++ YM +GL ++H+ Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHE 273 Query: 131 HWILHRDLKPNNLLL--DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + +H DLKP N++ + LKL DFGL P ++ T + APE+ G + Sbjct: 274 NNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPEVAEG-K 331 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 G DMW+VG + LL + G++D ETL W ++ D Sbjct: 332 PVGYYTDMWSVGVLSYILLSGLSPFGGENDD-------ETLRNVKSCDW----NMDDSA- 379 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG--CQ 306 FS +D D I+ L L +P R+T QAL+ + + PG PG Q Sbjct: 380 ------------FSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT--PGNAPGRDSQ 425 Query: 307 LP 308 +P Sbjct: 426 IP 427 >2X4F-A nrPDB Length = 373 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 134/288 (46%), Gaps = 36/288 (12%) Query: 14 KLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 K + LG G+F V+K + T +A K IK + ++ N EI ++ +L H N Sbjct: 93 KTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN-----EISVMNQLDHAN 147 Query: 74 IIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 +I L DAF K++I LV ++++ +L I D S LT +M +G+ ++HQ + Sbjct: 148 LIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMY 207 Query: 133 ILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 ILH DLKP N+L +K+ DFGLA+ + P T + APE++ Sbjct: 208 ILHLDLKPENILCVNRDAKQIKIIDFGLARRY-KPREKLKVNFGTPEFLAPEVV-NYDFV 265 Query: 191 GVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 DMW+VG I LL + PFL GD+D + L I +E++ D+ Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFL-GDNDAETLNNILACRWDLEDEEFQDIS-------- 316 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 ++ + I L + RI+A++ALK + S+ Sbjct: 317 ----------------EEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >4YNZ-A nrPDB Length = 342 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 69/213 (32%), Positives = 104/213 (48%), Gaps = 30/213 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+GQ V T Q VAIK + +R + + + REI +L+ + HP+++ L Sbjct: 18 LGKGQTGLVKLGIHCVTCQKVAIKIV---NREKLSESVLMKVEREIAILKLIEHPHVLKL 74 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 D + +K + LV + + + ++K L TP + + + L++ H H I H Sbjct: 75 HDVYENKKYLYLVLEHVSGGELFDYLVKKGRL--TPKEARKFFRQIISALDFCHSHSICH 132 Query: 136 RDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRAPELLF 185 RDLKP NLLLDE +++ADFG+A S GSP+ Y PE++ Sbjct: 133 RDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPH-----------YACPEVIR 181 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 G + G D+W+ G IL LL V LP D D Sbjct: 182 GEKYDGRKADVWSCGVILFALL--VGALPFDDD 212 >3GUB-A nrPDB Length = 295 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 73/229 (31%), Positives = 114/229 (49%), Gaps = 27/229 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQELS 70 Y+ + LG GQFA V K R+K+T A K IK ++ G++R + RE+ +L+E+ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 71 HPNIIGLLDAFGHKSNISLV---------FDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 HPN+I L + + +K+++ L+ FDF+ LT ++ Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLA---------EKESLTEEEATEFLKQI 123 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGV----LKLADFGLAKSFGSPNRAYTHQVVTRW 177 L G+ YLH I H DLKP N++L + V +K+ DFGLA N + + T Sbjct: 124 LNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPE 182 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRI 225 + APE++ G+ DMW++G I LL PFL GD+ + L + Sbjct: 183 FVAPEIV-NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANV 229 >2V7O-A nrPDB Length = 336 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 90/293 (30%), Positives = 134/293 (45%), Gaps = 37/293 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + K Q A K I S A+D ++ RE ++ + L H Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLS-ARD--HQKLEREARICRLLKH 89 Query: 72 PNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ L D+ + LVFD + E +++ ++ SH + L+ + ++ Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC---IHQILESVNHI 146 Query: 129 HQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQH I+HRDLKP NLLL + +KLADFGLA +A+ T Y +PE+L Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL- 205 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ ++++ + + Sbjct: 206 RKDPYGKPVDIWACGVILYILLVGYPPF---WDEDQ-HKLYQQIKAGAYD---------- 251 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + A +LI + NP RITA QALK + R Sbjct: 252 ------FPSPEWDTVTPEAK----NLINQMLTINPAKRITADQALKHPWVCQR 294 >3I6U-A nrPDB Length = 419 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 84/292 (28%), Positives = 137/292 (46%), Gaps = 41/292 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIK-----KIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LG G V A ++ T + VAI+ K +G EA +N EI++L++L+HP Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVET--EIEILKKLNHP 200 Query: 73 NIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 II + + F + + +V + ME + ++ + L + K Y L ++YLH+ Sbjct: 201 CIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRL--KEATCKLYFYQMLLAVQYLHE 257 Query: 131 HWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL--F 185 + I+HRDLKP N+LL +E+ ++K+ DFG +K G + T T Y APE+L Sbjct: 258 NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYLAPEVLVSV 316 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G Y VD W++G IL L G P + SL D Sbjct: 317 GTAGYNRAVDCWSLGVILFICL---------------------SGYPPFSEHRTQVSLKD 355 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 +T + IP +++ + LDL++ L + +P AR T +AL+ + + Sbjct: 356 QITSGKYNFIP--EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >2XNP-A nrPDB Length = 279 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 71/217 (32%), Positives = 108/217 (49%), Gaps = 17/217 (7%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 SRA+ YE L +G G + K R K+ +I+ K++ G +EA+ + + E+ LL Sbjct: 3 SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE---KQMLVSEVNLL 59 Query: 67 QELSHPNIIGLLDAFGHKSNISL--VFDFMET-DLEVIIKDNS---LVLTPSHIKAYMLM 120 +EL HPNI+ D ++N +L V ++ E DL +I + L + M Sbjct: 60 RELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQ 119 Query: 121 TLQGLEYLHQ-----HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVT 175 L+ H+ H +LHRDLKP N+ LD +KL DFGLA+ V T Sbjct: 120 LTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGT 179 Query: 176 RWYRAPELLFGARM-YGVGVDMWAVGCILAELLLRVP 211 +Y +PE + RM Y D+W++GC+L EL +P Sbjct: 180 PYYMSPEQM--NRMSYNEKSDIWSLGCLLYELCALMP 214 >2VN9-A nrPDB Length = 301 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 91/298 (30%), Positives = 134/298 (44%), Gaps = 37/298 (12%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 S Y+ + LG+G F+ V + T Q A K I S A+D ++ RE ++ Sbjct: 1 SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLS-ARD--HQKLEREARIC 57 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + L HPNI+ L D+ + LVFD + E +++ ++ SH + L+ Sbjct: 58 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC---IQQILE 114 Query: 124 GLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + + H + I+HRDLKP NLLL + +KLADFGLA +A+ T Y + Sbjct: 115 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE+L YG VDMWA G IL LL+ P D DQ R+++ + + Sbjct: 175 PEVL-RKDPYGKPVDMWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAYD----- 224 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + A DLI + NP RITA++ALK + R Sbjct: 225 -----------FPSPEWDTVTPEAK----DLINKMLTINPAKRITASEALKHPWICQR 267 >5DBX-A nrPDB Length = 328 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 133/304 (43%), Gaps = 45/304 (14%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 YE + +G G A V A K + VAIK+I L + D + L+EI+ + + SH Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDEL----LKEIQAMSQCSH 68 Query: 72 PNIIGLLDAFGHKSNISLVFDFME--TDLEVII------KDNSLVLTPSHIKAYMLMTLQ 123 PN++ +F K + LV + + L++I + + VL + I + L+ Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLE 128 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-----NRAYTHQVVTRWY 178 GL+YLH++ +HRDLK N+LL E+G +++ADFG++ + N+ V T + Sbjct: 129 GLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCW 188 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE++ R Y DMW+ G EL G ++P Sbjct: 189 MAPEVMEQVRGYDFKADMWSFGITAIEL---------------------ATGAAPYHKYP 227 Query: 239 DMCSLPDYVTFKSFP-----GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 M L +T ++ P G+ + G L+ +P R TA + LK K Sbjct: 228 PMKVL--MLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCK 285 Query: 294 YFSN 297 +F Sbjct: 286 FFQK 289 >6FDY-U nrPDB Length = 276 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 72/202 (35%), Positives = 105/202 (51%), Gaps = 18/202 (8%) Query: 18 LGEGQFATVYKA-RDKNTNQIVAIKKIKLGHRSEAKDGINRTA----LREIKLLQELSHP 72 LG G +ATVYKA K+T ++VAIK + AK +N+ + L EI++L+ + HP Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCV-------AKKSLNKASVENLLTEIEILKGIRHP 71 Query: 73 NIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 +I+ L D NI L+ +F DL I +L + +M L++LH+ Sbjct: 72 HIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRR-ILPEKVARVFMQQLASALQFLHER 130 Query: 132 WILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 I H DLKP N+LL E LKLADFG A+ + + + + Y APE++ R Sbjct: 131 NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR-GSPLYMAPEMV-CQRQ 188 Query: 190 YGVGVDMWAVGCILAELLLRVP 211 Y VD+W++G IL E L P Sbjct: 189 YDARVDLWSMGVILYEALFGQP 210 >6E2O-A nrPDB Length = 295 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 66/202 (32%), Positives = 100/202 (49%), Gaps = 16/202 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G + VY RD + +AIK+I E ++ EI L + L H NI+ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEI-----PERDSRYSQPLHEEIALHKHLKHKNIVQY 84 Query: 78 LDAFGHKSNISLVFDFMET----DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQH 131 L +F I + FME L +++ L I Y L+GL+YLH + Sbjct: 85 LGSFSENGFIKI---FMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDN 141 Query: 132 WILHRDLKPNNLLLDE-NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL-FGARM 189 I+HRD+K +N+L++ +GVLK++DFG +K N T Y APE++ G R Sbjct: 142 QIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRG 201 Query: 190 YGVGVDMWAVGCILAELLLRVP 211 YG D+W++GC + E+ P Sbjct: 202 YGKAADIWSLGCTIIEMATGKP 223 >5DYK-A nrPDB Length = 853 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 86/251 (34%), Positives = 121/251 (48%), Gaps = 27/251 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D K E +G G F TV K T A+K + + IN I Sbjct: 533 DTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVS------KRSIINLNQQNNI 586 Query: 64 KLLQELS----HPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYM 118 KL +E++ HP II L+ F + + + +L I+ L L+ S + Y+ Sbjct: 587 KLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGL-LSKSQAQFYL 645 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + +EYLH+ I++RDLKP N+LLD+ G +KL DFG AK RAYT V T Y Sbjct: 646 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV--QGRAYT-LVGTPHY 702 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE++ G + YG VD+WA+G L E + +PF G+ + DQL IF + T Sbjct: 703 MAPEVILG-KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQL-EIFRDILTG----- 753 Query: 238 PDMCSLPDYVT 248 + PDYVT Sbjct: 754 --QLTFPDYVT 762 >2JDO-A nrPDB Length = 342 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 72/232 (31%), Positives = 109/232 (46%), Gaps = 15/232 (6%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSE---AKDGINRT 58 A+D K ++ L LG+G F V R+K T + A+K + R E AKD + T Sbjct: 2 AMDPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKIL----RKEVIIAKDEVAHT 57 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYM 118 + E ++LQ HP + L AF + V ++ V T + Y Sbjct: 58 -VTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYG 116 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + LEYLH +++RD+K NL+LD++G +K+ DFGL K S T Y Sbjct: 117 AEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEY 176 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETL 229 APE+L YG VD W +G ++ E++ R+PF D + R+FE + Sbjct: 177 LAPEVL-EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----RLFELI 222 >6CMJ-A nrPDB Length = 321 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 82/303 (27%), Positives = 140/303 (46%), Gaps = 38/303 (12%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEA---KDGINRTALREIK 64 +Y D +G+G + V A ++N N A+K K KL ++ G +EI Sbjct: 35 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIA 94 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMTLQ 123 +L++L HPN++ L++ + L F + +++ +L L+ + Y ++ Sbjct: 95 ILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIK 154 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+EYLH I+HRD+KP+NLL+ E+G +K+ADFG++ F + ++ V T + APE Sbjct: 155 GIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPES 214 Query: 184 LFGAR--MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 L R G +D+WA+G L + + PF +D+ + ++PD Sbjct: 215 LSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------MDERIMCLHSKIKSQALEFPDQ 268 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 PD +DL DLI + NP +RI + +K+ + R G Sbjct: 269 ---PD------------------IAEDLKDLITRMLDKNPESRIVVPE-IKLHPWVTRHG 306 Query: 301 PTP 303 P Sbjct: 307 AEP 309 >4YZB-A nrPDB Length = 491 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 88/325 (27%), Positives = 141/325 (43%), Gaps = 39/325 (12%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ LG+G F V +DK T Q A+K I + D E+ + Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 HPNI+ L + F K LV + E E+I + + + I + L G+ Sbjct: 89 --HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARI---IRQVLSGI 143 Query: 126 EYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 Y+H++ I+HRDLKP NLLL+ ++ +++ DFGL+ F S + ++ T +Y APE Sbjct: 144 TYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKK-MKDKIGTAYYIAPE 202 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L G Y D+W+ G IL LL P G ++ D L ++ + T QW + Sbjct: 203 VLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKV-- 258 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 S P DLI+ + + P RI+A AL+ ++ T Sbjct: 259 --------SEPA--------------KDLIRKMLAYVPTMRISARDALEHEWLKTTDAAT 296 Query: 303 PGCQLPRPNCPVETLKE-QSNPALA 326 +P + +++ Q LA Sbjct: 297 DSIDVPSLESTILNIRQFQGTQKLA 321 >5D9K-A nrPDB Length = 330 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 72/232 (31%), Positives = 115/232 (49%), Gaps = 10/232 (4%) Query: 6 KSRAKRYEKLDFLGEGQFATVY---KARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 K+ ++E L LG+G F V+ K + Q+ A+K +K + +D + R+ Sbjct: 26 KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKA-TLKVRDRVRTKMERD 84 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I L E++HP I+ L AF + + L+ DF+ ++ T +K Y+ Sbjct: 85 I--LVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQVVTRWYRAP 181 L++LH I++RDLKP N+LLDE G +KL DFGL+K S +AY+ T Y AP Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSF-CGTVEYMAP 201 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET-LGTP 232 E++ R + D W+ G ++ E+L G + +T I + LG P Sbjct: 202 EVV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >3DB8-A nrPDB Length = 317 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 60/204 (29%), Positives = 104/204 (50%), Gaps = 7/204 (3%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKI--KLGHRSEAKDGINRTALREIKLLQ 67 KRY + FLG+G FA Y+ D +T ++ A K + + + K+ ++ EI + + Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMST----EIAIHK 97 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 L +P+++G F + +V + + + +T + +M T+QG++Y Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTIQGVQY 157 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 LH + ++HRDLK NL L+++ +K+ DFGLA T Y APE+L Sbjct: 158 LHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL-CK 216 Query: 188 RMYGVGVDMWAVGCILAELLLRVP 211 + + VD+W++GCIL LL+ P Sbjct: 217 KGHSFEVDIWSLGCILYTLLVGKP 240 >4EQM-A nrPDB Length = 294 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 68/210 (32%), Positives = 112/210 (53%), Gaps = 6/210 (2%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +RY+ +D LG G +TVY A D N VAIK I + R E ++ + R RE+ +L Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPR-EKEETLKRFE-REVHNSSQL 68 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 SH NI+ ++D LV +++E L I+ + + + I + L G+++ Sbjct: 69 SHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAIN-FTNQILDGIKHA 127 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELLFGA 187 H I+HRD+KP N+L+D N LK+ DFG+AK+ + T+ V+ T Y +PE G Sbjct: 128 HDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKG- 186 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDS 217 D++++G +L E+L+ P G++ Sbjct: 187 EATDECTDIYSIGIVLYEMLVGEPPFNGET 216 >2YAB-A nrPDB Length = 361 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 71/226 (31%), Positives = 113/226 (50%), Gaps = 33/226 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQELSHPNIIG 76 LG GQFA V K R+K+T A K IK ++ G+ R + RE+ +L+++ HPNII Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPNIIT 79 Query: 77 LLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L D + +++++ L+ + + + + + SL + +++ L G+ YLH I Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESL--SEEEATSFIKQILDGVNYLHTKKIA 137 Query: 135 HRDLKPNNLLLDENGV----LKLADFGLAKS----------FGSPNRAYTHQVVTRWYRA 180 H DLKP N++L + + +KL DFGLA FG+P + A Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE-----------FVA 186 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRI 225 PE++ G+ DMW++G I LL PFL GD+ + L I Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANI 230 >2JD5-A nrPDB Length = 373 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 80/249 (32%), Positives = 126/249 (50%), Gaps = 39/249 (15%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY + LG G F+TV+ A+D N VA+K ++ A EIKLLQ ++ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR------GDKVYTEAAEDEIKLLQRVN 73 Query: 71 HPN-----------IIGLLDAFGHKS----NISLVFDFMETDLEVIIKDNSLVLTP-SHI 114 + I+ LLD F HK ++ +VF+ + +L +IK P ++ Sbjct: 74 DADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYV 133 Query: 115 KAYMLMTLQGLEYLHQHW-ILHRDLKPNNLLLD-----ENGV-LKLADFGLAKSFGSPNR 167 K L GL+Y+H+ I+H D+KP N+L++ EN + +K+AD G A + + Sbjct: 134 KQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY---DE 190 Query: 168 AYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDS-----DLDQ 221 YT+ + TR YR+PE+L GA +G G D+W+ C++ EL+ F P + D D Sbjct: 191 HYTNSIQTREYRSPEVLLGAP-WGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDH 249 Query: 222 LTRIFETLG 230 + +I E LG Sbjct: 250 IAQIIELLG 258 >6HXF-B nrPDB Length = 302 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 61/200 (30%), Positives = 101/200 (50%), Gaps = 10/200 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG+G F VYKA++K T + A K I+ E +D I EI++L H Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYI-----VEIEILATCDH 75 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P I+ LL A+ H + ++ +F ++ I+ + LT I+ L+ L +LH Sbjct: 76 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM- 189 I+HRDLK N+L+ G ++LADFG++ + + T ++ APE++ M Sbjct: 136 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 195 Query: 190 ---YGVGVDMWAVGCILAEL 206 Y D+W++G L E+ Sbjct: 196 DTPYDYKADIWSLGITLIEM 215 >5KZ7-A nrPDB Length = 346 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 68/204 (33%), Positives = 106/204 (51%), Gaps = 20/204 (9%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL----REIKLLQ 67 Y L +G+G FA V AR T + VA+K I K +N ++L RE+++++ Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIID-------KTQLNSSSLQKLFREVRIMK 87 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV----LTPSHIKAYMLMTLQ 123 L+HPNI+ L + + + LV ++ EV + LV + +A + Sbjct: 88 VLNHPNIVKLFEVIETEKTLYLVMEYASGG-EVF---DYLVAHGRMKEKEARAKFRQIVS 143 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 ++Y HQ +I+HRDLK NLLLD + +K+ADFG + F N+ T + Y APEL Sbjct: 144 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTF-CGSPPYAAPEL 202 Query: 184 LFGARMYGVGVDMWAVGCILAELL 207 G + G VD+W++G IL L+ Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLV 226 >2VZ6-A nrPDB Length = 313 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 88/293 (30%), Positives = 134/293 (45%), Gaps = 37/293 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + Q A K I S A+D ++ RE ++ + L H Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS-ARD--HQKLEREARICRLLKH 80 Query: 72 PNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ L D+ + + L+FD + E +++ ++ SH + L+ + + Sbjct: 81 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHC---IQQILEAVLHC 137 Query: 129 HQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQ ++HRDLKP NLLL + +KLADFGLA +A+ T Y +PE+L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL- 196 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ R+++ + + Sbjct: 197 RKDPYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAYD---------- 242 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + A DLI + NP RITA +ALK + S+R Sbjct: 243 ------FPSPEWDTVTPEAK----DLINKMLTINPSKRITAAEALKHPWISHR 285 >1KOB-A nrPDB Length = 387 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 108/217 (49%), Gaps = 10/217 (4%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ L+ LG G F V++ +K T ++ K I + + T EI ++ +L H Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLD-----KYTVKNEISIMNQLHH 107 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P +I L DAF K + L+ +F+ +L I ++ + + YM +GL+++H+ Sbjct: 108 PKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE 167 Query: 131 HWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H I+H D+KP N++ + + +K+ DFGLA +P+ T + APE++ Sbjct: 168 HSIVHLDIKPENIMCETKKASSVKIIDFGLATKL-NPDEIVKVTTATAEFAAPEIV-DRE 225 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 G DMWA+G + LL + G+ DL+ L + Sbjct: 226 PVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNV 262 >2HAK-A nrPDB Length = 328 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 70/214 (32%), Positives = 109/214 (50%), Gaps = 20/214 (9%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL- 60 A D + Y +G+G FA V AR T + VA+K I K +N T+L Sbjct: 7 ATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIID-------KTQLNPTSLQ 59 Query: 61 ---REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV----LTPSH 113 RE+++++ L+HPNI+ L + + + LV ++ + EV + LV + Sbjct: 60 KLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYA-SGGEVF---DYLVAHGRMKEKE 115 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV 173 +A + ++Y HQ +I+HRDLK NLLLD + +K+ADFG + F N+ T Sbjct: 116 ARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF-C 174 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + Y APEL G + G VD+W++G IL L+ Sbjct: 175 GSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV 208 >3A8W-A nrPDB Length = 345 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 66/209 (31%), Positives = 105/209 (50%), Gaps = 4/209 (1%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 ++ L +G G +A V R K T++I A+K +K ++ +D I+ + Q +H Sbjct: 11 FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDED-IDWVQTEKHVFEQASNH 69 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P ++GL F +S + V +++ + L H + Y L YLH+ Sbjct: 70 PFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER 129 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 I++RDLK +N+LLD G +KL D+G+ K P + T Y APE+L G YG Sbjct: 130 GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGED-YG 188 Query: 192 VGVDMWAVGCILAELLL-RVPF-LPGDSD 218 VD WA+G ++ E++ R PF + G SD Sbjct: 189 FSVDWWALGVLMFEMMAGRSPFDIVGSSD 217 >5J5T-A nrPDB Length = 370 Score = 94.0 bits (232), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 62/197 (31%), Positives = 97/197 (49%), Gaps = 7/197 (3%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + +G G + VYKAR+ NT ++ AIK IKL + +EI ++++ H Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFA-----VVQQEIIMMKDCKH 60 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 PNI+ ++ + + + +F I + L+ I TLQGL YLH Sbjct: 61 PNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 +HRD+K N+LL +NG +KLADFG++ + + T ++ APE+ R G Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 192 VG--VDMWAVGCILAEL 206 D+WAVG EL Sbjct: 181 YNQLCDLWAVGITAIEL 197 >5WAX-A nrPDB Length = 310 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 91/330 (27%), Positives = 141/330 (42%), Gaps = 43/330 (13%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M + + RYE + +G G F R++ Q+VA+K I+ G + I+ Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEK------IDENVQ 55 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYM 118 REI + L HPNII + +++++V ++ E I N+ + + + Sbjct: 56 REIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFF 113 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTR 176 + G+ Y H + HRDLK N LLD + LK+ DFG +KS ++ + V T Sbjct: 114 QQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKS-TVGTP 172 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEE 235 Y APE+L G D+W+ G L +L+ PF D + I LG Sbjct: 173 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV---- 228 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 Q+ S+PDYV HI + DLI +F+ NP RIT + +F Sbjct: 229 QY----SIPDYV-----------HI----SPECQDLISRIFVANPATRITIPEIRNHPWF 269 Query: 296 -SNRPG-----PTPGCQLPRPNCPVETLKE 319 N P T Q P P++++ E Sbjct: 270 LKNLPADLMDDSTMSKQYEEPEQPMQSMDE 299 >5U6Y-A nrPDB Length = 461 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 88/293 (30%), Positives = 134/293 (45%), Gaps = 37/293 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + Q A K I S A+D ++ RE ++ + L H Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS-ARD--HQKLEREARICRLLKH 58 Query: 72 PNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ L D+ + + L+FD + E +++ ++ SH + L+ + + Sbjct: 59 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHC---IQQILEAVLHC 115 Query: 129 HQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQ ++HRDLKP NLLL + +KLADFGLA +A+ T Y +PE+L Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL- 174 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ R+++ + + Sbjct: 175 RKDPYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAYD---------- 220 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + A DLI + NP RITA +ALK + S+R Sbjct: 221 ------FPSPEWDTVTPEAK----DLINKMLTINPSKRITAAEALKHPWISHR 263 >5YKS-A nrPDB Length = 377 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 102/212 (48%), Gaps = 6/212 (2%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG G FA V AR T + VA+K I G +R +KL+Q HPNI+ L Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ---HPNIVRL 99 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + ++ + L+ + + D+ I + L K Y + + Y H+ ++HR Sbjct: 100 YEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHR 159 Query: 137 DLKPNNLLL-DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVD 195 DLKP N++ ++ G++KL DFG + F P + T + Y APE+L G VD Sbjct: 160 DLKPENVVFFEKQGLVKLTDFGFSNKF-QPGKKLTTSCGSLAYSAPEILLGDEYDAPAVD 218 Query: 196 MWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 +W++G IL L+ P +D + LT I + Sbjct: 219 IWSLGVILFMLVCGQPPFQEANDSETLTMIMD 250 >4FR4-A nrPDB Length = 384 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 70/242 (28%), Positives = 120/242 (49%), Gaps = 18/242 (7%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTALREIKLLQE 68 +E L +G+G F V + +T ++ A+K K K R+E R +E++++Q Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEV-----RNVFKELQIMQG 71 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 L HP ++ L +F + ++ +V D + DL ++ N + +K ++ + L+Y Sbjct: 72 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQN-VHFKEETVKLFICELVMALDY 130 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 L I+HRD+KP+N+LLDE+G + + DF +A + T T+ Y APE +F + Sbjct: 131 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITT-MAGTKPYMAPE-MFSS 188 Query: 188 RM---YGVGVDMWAVGCILAELLL-RVPF-LPGDSDLDQLTRIFETLGTPTEEQWP-DMC 241 R Y VD W++G ELL R P+ + + ++ FET W +M Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMV 248 Query: 242 SL 243 SL Sbjct: 249 SL 250 >5F9E-A nrPDB Length = 353 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/219 (31%), Positives = 109/219 (49%), Gaps = 5/219 (2%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 +L +K + + +E LG+G F V+ A K TNQ AIK +K D + T + Sbjct: 11 SLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK-KDVVLMDDDVECTMVE 69 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLM 120 + L HP + + F K N+ V +++ DL I+ + S Y Sbjct: 70 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ-SCHKFDLSRATFYAAE 128 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + GL++LH I++RDLK +N+LLD++G +K+ADFG+ K + T Y A Sbjct: 129 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIA 188 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSD 218 PE+L G + Y VD W+ G +L E+L+ + PF D + Sbjct: 189 PEILLGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQDEE 226 >5IG1-A nrPDB Length = 344 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/205 (33%), Positives = 103/205 (50%), Gaps = 14/205 (6%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 +K +G+G F+TV++ +K T ++ A+K I L +S IN+ REI + L H Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIAL--KSLRSSEINKIK-REIGICSSLQHE 76 Query: 73 NIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 +I+ + AF +S+ LVF+++ E E++ + A M L L++ H Sbjct: 77 HIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRK---FYNEKDASACMHQILSALQHCH 133 Query: 130 QHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I+HRDLKP NLLL D N +K+ DFGLA Y T Y +PE++ Sbjct: 134 SKNIIHRDLKPENLLLASKDPNAPVKITDFGLA-VIMEQGPTYFGFAGTPGYLSPEVIRR 192 Query: 187 ARMYGVGVDMWAVGCILAELLLRVP 211 Y VD+WA G IL LL+ P Sbjct: 193 V-PYDTAVDVWACGVILYILLVGYP 216 >6C9D-A nrPDB Length = 459 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/214 (32%), Positives = 108/214 (50%), Gaps = 20/214 (9%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL- 60 A D + Y +G+G FA V AR T + VA+K I K +N T+L Sbjct: 13 ATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIID-------KTQLNPTSLQ 65 Query: 61 ---REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV----LTPSH 113 RE+++++ L+HPNI+ L + + + LV ++ + EV + LV + Sbjct: 66 KLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYA-SGGEVF---DYLVAHGRMKEKE 121 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV 173 +A + ++Y HQ +I+HRDLK NLLLD + +K+ADFG + F N+ Sbjct: 122 ARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDEFC 180 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + Y APEL G + G VD+W++G IL L+ Sbjct: 181 GSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV 214 >3DAK-A nrPDB Length = 290 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/208 (31%), Positives = 103/208 (49%), Gaps = 17/208 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 YE + +G G A V A + VAIK+I L + D + L+EI+ + + H Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL----LKEIQAMSQCHH 67 Query: 72 PNIIGLLDAFGHKSNISLVFDFME--TDLEVII------KDNSLVLTPSHIKAYMLMTLQ 123 PNI+ +F K + LV + + L++I + S VL S I + L+ Sbjct: 68 PNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLE 127 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-----NRAYTHQVVTRWY 178 GLEYLH++ +HRD+K N+LL E+G +++ADFG++ + N+ V T + Sbjct: 128 GLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCW 187 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAEL 206 APE++ R Y D+W+ G EL Sbjct: 188 MAPEVMEQVRGYDFKADIWSFGITAIEL 215 >1PHK-A nrPDB Length = 298 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 82/301 (27%), Positives = 125/301 (41%), Gaps = 41/301 (13%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKL----GHRSEAKDGINRTALREIKL 65 + YE + LG G + V + K T + A+K I + +E + L+E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 66 LQELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L+++S HPNII L D + + LVFD M+ + L+ + M L+ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 + LH+ I+HRDLKP N+LLD++ +KL DFG + P T Y APE++ Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL-DPGEKLREVCGTPSYLAPEII 195 Query: 185 FGARM-----YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE---TLGTPTEEQ 236 + YG VDMW+ G I+ LL P + L I G+P + Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSP---E 252 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 W D D + DL+ + P R TA +AL +F Sbjct: 253 WDDY------------------------SDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 Query: 297 N 297 Sbjct: 289 Q 289 >4B8L-A nrPDB Length = 286 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 96/208 (46%), Gaps = 5/208 (2%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G+F VY AR+K I+A+K L K+G+ REI++ L HPNI+ + Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKV--LFKSQLEKEGVEHQLRREIEIQSHLRHPNILRM 80 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRD 137 + F + I L+ +F +M L Y H+ ++HRD Sbjct: 81 YNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRD 140 Query: 138 LKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMW 197 +KP NLL+ G LK+ADFG S +P+ T Y PE++ G + + VD+W Sbjct: 141 IKPENLLMGYKGELKIADFGW--SVHAPSLRRRTMCGTLDYLPPEMIEG-KTHDEKVDLW 197 Query: 198 AVGCILAELLLRVPFLPGDSDLDQLTRI 225 G + E L+ +P S + RI Sbjct: 198 CAGVLCYEFLVGMPPFDSPSHTETHRRI 225 >5FG8-A nrPDB Length = 285 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 87/293 (29%), Positives = 138/293 (47%), Gaps = 37/293 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + K+T A K I + A+D + RE ++ ++L H Sbjct: 16 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINT-KKLTARDF--QKLEREARICRKLHH 72 Query: 72 PNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ L D+ ++ LVFD + E +++ ++ SH + L+ + + Sbjct: 73 PNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHC---IQQILESVNHC 129 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQ+ ++HRDLKP NLLL + +KLADFGLA ++A+ T Y +PE+L Sbjct: 130 HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL- 188 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ R++ + + +P P+ Sbjct: 189 KKEPYGKSVDIWACGVILYILLVGYPPF---WDEDQ-HRLYSQIKAGAYD-YPS----PE 239 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + T + +LI + NP RITA +ALK + R Sbjct: 240 WDTVTP---------------EAKNLINQMLTVNPNKRITAAEALKHPWICQR 277 >2W4O-A nrPDB Length = 349 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 92/296 (31%), Positives = 130/296 (43%), Gaps = 59/296 (19%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG G + VY+ + K T + A+K +K I RT EI +L LSHPNII L Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLK----KTVDKKIVRT---EIGVLLRLSHPNIIKL 113 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + F + ISLV + + + I++ + + L+ + YLH++ I+H Sbjct: 114 KEIFETPTEISLVLELVTGGELFDRIVEKG--YYSERDAADAVKQILEAVAYLHENGIVH 171 Query: 136 RDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVV------TRWYRAPELLFG 186 RDLKP NLL + LK+ADFGL+K HQV+ T Y APE+L G Sbjct: 172 RDLKPENLLYATPAPDAPLKIADFGLSK-------IVEHQVLMKTVCGTPGYCAPEILRG 224 Query: 187 ARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFET---LGTPTEEQWPDMCS 242 YG VDMW+VG I LL PF D RI +P W D S Sbjct: 225 C-AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISP----WWDEVS 279 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 L + DL++ L + +P R+T QAL+ + + + Sbjct: 280 L-----------------------NAKDLVRKLIVLDPKKRLTTFQALQHPWVTGK 312 >4RLP-A nrPDB Length = 288 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 116/234 (49%), Gaps = 23/234 (9%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARD---KNTNQIVAIKKIKLGH-RSEAKDGINRTALR 61 K R + +E L LG+G + V++ R NT +I A+K +K AKD + A R Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFD-------FMETDLEVIIKDNSLVLTPSHI 114 I L+E+ HP I+ L+ AF + L+ + FM+ + E I +++ Sbjct: 61 NI--LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF----- 113 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV 174 Y+ L +LHQ I++RDLKP N++L+ G +KL DFGL K + TH Sbjct: 114 --YLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFC 170 Query: 175 -TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 T Y APE+L + + VD W++G ++ ++L P G++ + +I + Sbjct: 171 GTIEYMAPEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 223 >5FET-A nrPDB Length = 847 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 85/251 (33%), Positives = 119/251 (47%), Gaps = 27/251 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D K E +G G F TV K T A+K + + I+ I Sbjct: 527 DTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVS------KRSIISLNQQNNI 580 Query: 64 KLLQELS----HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYM 118 KL +E++ HP II L+ F SN + T E+ L +L+ + Y+ Sbjct: 581 KLEREITAENDHPFIIRLVRTF-KDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYL 639 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + +EYLH+ I++RDLKP N+LLD+ G +KL DFG AK RAYT V T Y Sbjct: 640 GSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI--QGRAYT-LVGTPHY 696 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE++ G + YG VD+WA+G L E + +PF G+ DQL IF + T Sbjct: 697 MAPEVILG-KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQL-EIFRDILTG----- 747 Query: 238 PDMCSLPDYVT 248 + PDYV+ Sbjct: 748 --QLTFPDYVS 756 >3F3Z-A nrPDB Length = 277 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 82/291 (28%), Positives = 127/291 (43%), Gaps = 39/291 (13%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G + V A K T A KKI + E D + EI++++ L HPNII L Sbjct: 17 IGRGSWGEVKIAVQKGTRIRRAAKKIP-KYFVEDVDRFKQ----EIEIMKSLDHPNIIRL 71 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + F ++I LV + E ++ + V S M L + Y H+ + H Sbjct: 72 YETFEDNTDIYLVMELCTGGELFERVV--HKRVFRESDAARIMKDVLSAVAYCHKLNVAH 129 Query: 136 RDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 RDLKP N L + LKL DFGLA F P + +V T +Y +P++L G +YG Sbjct: 130 RDLKPENFLFLTDSPDSPLKLIDFGLAARF-KPGKMMRTKVGTPYYVSPQVLEG--LYGP 186 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 D W+ G ++ LL P +D + + +I E T E+ W ++ + Sbjct: 187 ECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAE------- 239 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 LI+ L +P RIT+ QAL+ ++F + +P Sbjct: 240 -----------------SLIRRLLTKSPKQRITSLQALEHEWFEKQLSSSP 273 >4M7I-A nrPDB Length = 299 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 68/229 (29%), Positives = 113/229 (49%), Gaps = 44/229 (19%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V++A++K + AIK+I+L +R A++ + +RE+K L +L H Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV----MREVKALAKLEH 62 Query: 72 PNIIGLLDAFGHKSNISLV---------------------FDFMETDLEVIIKDNSLVLT 110 P I+ +A+ K+ + D+M + ++ S+ L Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL- 121 Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG------- 163 HI L + +E+LH ++HRDLKP+N+ + V+K+ DFGL + Sbjct: 122 --HI---FLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQT 176 Query: 164 --SPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 +P AY T QV T+ Y +PE + G Y VD++++G IL ELL Sbjct: 177 VLTPMPAYARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL 224 >4L42-A nrPDB Length = 346 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 116/234 (49%), Gaps = 23/234 (9%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARD---KNTNQIVAIKKIKLGH-RSEAKDGINRTALR 61 K R + +E L LG+G + V++ R NT +I A+K +K AKD + A R Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 73 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFD-------FMETDLEVIIKDNSLVLTPSHI 114 I L+E+ HP I+ L+ AF + L+ + FM+ + E I +++ Sbjct: 74 NI--LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACF----- 126 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV 174 Y+ L +LHQ I++RDLKP N++L+ G +KL DFGL K + TH Sbjct: 127 --YLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFC 183 Query: 175 -TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 T Y APE+L + + VD W++G ++ ++L P G++ + +I + Sbjct: 184 GTIEYMAPEILMRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 236 >4REW-A nrPDB Length = 540 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 71/215 (33%), Positives = 103/215 (47%), Gaps = 29/215 (13%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG G F V + + T VA+K + + + D + + REI+ L+ HP+II Sbjct: 12 DTLGVGTFGKVKVGKHELTGHKVAVKILN-RQKIRSLDVVGKIR-REIQNLKLFRHPHII 69 Query: 76 GLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 L S+I +V +++ + I K+ L S + L G++Y H+H + Sbjct: 70 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES--RRLFQQILSGVDYCHRHMV 127 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRAPEL 183 +HRDLKP N+LLD + K+ADFGL+ S GSPN Y APE+ Sbjct: 128 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----------YAAPEV 176 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 + G G VD+W+ G IL LL LP D D Sbjct: 177 ISGRLYAGPEVDIWSSGVILYALLCGT--LPFDDD 209 >2A27-A nrPDB Length = 321 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 113/226 (50%), Gaps = 33/226 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQELSHPNIIG 76 LG GQFA V K R+K+T A K IK ++ G++R + RE+ +L+++ H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 77 LLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L D + +++++ L+ + + + + + SL + +++ L G+ YLH I Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESL--SEEEATSFIKQILDGVNYLHTKKIA 137 Query: 135 HRDLKPNNLLLDENGV----LKLADFGLAKS----------FGSPNRAYTHQVVTRWYRA 180 H DLKP N++L + + +KL DFGLA FG+P + A Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE-----------FVA 186 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRI 225 PE++ G+ DMW++G I LL PFL GD+ + L I Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANI 230 >1ZWS-A nrPDB Length = 288 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 113/226 (50%), Gaps = 33/226 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQELSHPNIIG 76 LG GQFA V K R+K+T A K IK ++ G++R + RE+ +L+++ H N+I Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 77 LLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L D + +++++ L+ + + + + + SL + +++ L G+ YLH I Sbjct: 80 LHDVYENRTDVVLILELVSGGELFDFLAQKESL--SEEEATSFIKQILDGVNYLHTKKIA 137 Query: 135 HRDLKPNNLLLDENGV----LKLADFGLAKS----------FGSPNRAYTHQVVTRWYRA 180 H DLKP N++L + + +KL DFGLA FG+P + A Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE-----------FVA 186 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRI 225 PE++ G+ DMW++G I LL PFL GD+ + L I Sbjct: 187 PEIV-NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANI 230 >4RED-A nrPDB Length = 351 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 71/215 (33%), Positives = 103/215 (47%), Gaps = 29/215 (13%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG G F V + + T VA+K + + + D + + REI+ L+ HP+II Sbjct: 20 DTLGVGTFGKVKVGKHELTGHAVAVKILN-RQKIRSLDVVGKIR-REIQNLKLFRHPHII 77 Query: 76 GLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 L S+I +V +++ + I K+ L S + L G++Y H+H + Sbjct: 78 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES--RRLFQQILSGVDYCHRHMV 135 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRAPEL 183 +HRDLKP N+LLD + K+ADFGL+ S GSPN Y APE+ Sbjct: 136 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----------YAAPEV 184 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 + G G VD+W+ G IL LL LP D D Sbjct: 185 ISGRLYAGPEVDIWSSGVILYALLCGT--LPFDDD 217 >5ES1-A nrPDB Length = 328 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 64/200 (32%), Positives = 99/200 (49%), Gaps = 12/200 (6%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL----REIKLLQ 67 Y L +G+G FA V AR T + VAIK I K +N ++L RE+++++ Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIID-------KTQLNPSSLQKLFREVRIMK 69 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 L+HPNI+ L + + + LV ++ + + +A + + Y Sbjct: 70 GLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHY 129 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 HQ I+HRDLK NLLLD +K+ADFG + F ++ T + Y APEL G Sbjct: 130 CHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTF-CGSPPYAAPELFQGK 188 Query: 188 RMYGVGVDMWAVGCILAELL 207 + G VD+W++G IL L+ Sbjct: 189 KYDGPEVDIWSLGVILYTLV 208 >2QNJ-A nrPDB Length = 328 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 69/215 (32%), Positives = 107/215 (49%), Gaps = 20/215 (9%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M D + Y L +G+G FA V AR T + VAIK I K +N T+L Sbjct: 3 MGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIID-------KTQLNPTSL 55 Query: 61 ----REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV----LTPS 112 RE+++++ L+HPNI+ L + + + L+ ++ EV + LV + Sbjct: 56 QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGG-EVF---DYLVAHGRMKEK 111 Query: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ 172 ++ + ++Y HQ I+HRDLK NLLLD + +K+ADFG + F + T Sbjct: 112 EARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF- 170 Query: 173 VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + Y APEL G + G VD+W++G IL L+ Sbjct: 171 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV 205 >4CFH-A nrPDB Length = 493 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 71/215 (33%), Positives = 103/215 (47%), Gaps = 29/215 (13%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG G F V + + T VA+K + + + D + + REI+ L+ HP+II Sbjct: 39 DTLGVGTFGKVKVGKHELTGHKVAVKILN-RQKIRSLDVVGKIR-REIQNLKLFRHPHII 96 Query: 76 GLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 L S+I +V +++ + I K+ L S + L G++Y H+H + Sbjct: 97 KLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKES--RRLFQQILSGVDYCHRHMV 154 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRAPEL 183 +HRDLKP N+LLD + K+ADFGL+ S GSPN Y APE+ Sbjct: 155 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----------YAAPEV 203 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 + G G VD+W+ G IL LL LP D D Sbjct: 204 ISGRLYAGPEVDIWSSGVILYALLCGT--LPFDDD 236 >2WTK-C nrPDB Length = 305 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 80/320 (25%), Positives = 140/320 (43%), Gaps = 46/320 (14%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +Y D LGEG + V + D T A+K +K +G +EI+LL+ L Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNG-EANVKKEIQLLRRLR 64 Query: 71 HPNIIGLLDAF--GHKSNISLVFDFMETDLEVI---IKDNSLVLTPSHIKAYMLMTLQGL 125 H N+I L+D K + +V ++ ++ + + + + +H Y + GL Sbjct: 65 HKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH--GYFCQLIDGL 122 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKS---FGSPNRAYTHQVVTRWYRAPE 182 EYLH I+H+D+KP NLLL G LK++ G+A++ F + + T Q + ++ PE Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ-GSPAFQPPE 181 Query: 183 LLFGARMY-GVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 + G + G VD+W+ G L + + PF + D + ++FE +G + Sbjct: 182 IANGLDTFSGFKVDIWSAGVTLYNITTGLYPF-----EGDNIYKLFENIGKGS------- 229 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 + I G L DL++G+ + P R + Q + +F + Sbjct: 230 -----------------YAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKK-- 270 Query: 301 PTPGCQLPRPNCPVETLKEQ 320 P + P P P K++ Sbjct: 271 -HPPAEAPVPIPPSPDTKDR 289 >2BRG-A nrPDB Length = 297 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 85/297 (28%), Positives = 134/297 (45%), Gaps = 39/297 (13%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LGEG + V A ++ T + VA+K + + + + I + EI + + L+H N++ Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKK----EICINKMLNHENVVKF 70 Query: 78 LDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPS-HIKAYMLMTLQGLEYLHQHWIL 134 +GH+ ++ + F+E + E+ + + P + + + G+ YLH I Sbjct: 71 ---YGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGIT 127 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVTRWYRAPELLFGARMYGV 192 HRD+KP NLLLDE LK++DFGLA F NR T Y APELL + Sbjct: 128 HRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAE 187 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 VD+W+ G +L +L LP D D +++ D Y+ Sbjct: 188 PVDVWSCGIVLTAML--AGELPWDQPSDSC------------QEYSDWKEKKTYLN---- 229 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPR 309 P I SA L L+ + + NP ARIT K +++ N+P G + PR Sbjct: 230 ---PWKKIDSAP----LALLHKILVENPSARITIPDIKKDRWY-NKP-LKKGAKRPR 277 >6QAU-A nrPDB Length = 280 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 66/220 (30%), Positives = 112/220 (50%), Gaps = 18/220 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKN-TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Y K D +G G FA V++ R + T+ VAIK I + S+++ + + EIK+L+EL Sbjct: 13 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK----EIKILKELQ 68 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 H NI+ L D +++ LV ++ DL ++ L+ I+ ++ + LH Sbjct: 69 HENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG-TLSEDTIRVFLHQIAAAMRILH 127 Query: 130 QHWILHRDLKPNNLLLDE--------NGV-LKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 I+HRDLKP N+LL +G+ +K+ADFG A+ S N + Y A Sbjct: 128 SKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHS-NMMAADLCGSPMYMA 186 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLD 220 PE++ ++ Y D+W++G ++ + L+ P +S D Sbjct: 187 PEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD 225 >3SOA-A nrPDB Length = 444 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/300 (28%), Positives = 137/300 (45%), Gaps = 47/300 (15%) Query: 10 KRYEKLDFLGEGQFATVYK-----ARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + Y+ + LG+G F+ V + A + I+ KK+ A+D ++ RE + Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLS------ARD--HQKLEREAR 62 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMT 121 + + L HPNI+ L D+ + + L+FD + E +++ ++ SH + Sbjct: 63 ICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHC---IQQI 119 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L+ + + HQ ++HR+LKP NLLL + +KLADFGLA +A+ T Y Sbjct: 120 LEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGY 179 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 +PE+L YG VD+WA G IL LL+ P D DQ R+++ + + Sbjct: 180 LSPEVL-RKDPYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAYD--- 231 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + A DLI + NP RITA +ALK + S+R Sbjct: 232 -------------FPSPEWDTVTPEAK----DLINKMLTINPSKRITAAEALKHPWISHR 274 >5XZW-A nrPDB Length = 471 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 82/291 (28%), Positives = 137/291 (47%), Gaps = 47/291 (16%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + +G+G FATV KA ++ T + A+K I DG+ R E+++LQ+L+HP I+ Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTR----ELEVLQKLNHPRIV 257 Query: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + + +V +F+ DL + + V + + L ++Y+H I Sbjct: 258 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG-REISRQILTAIKYIHSMGIS 316 Query: 135 HRDLKPNNLLLDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM--- 189 HRDLKP+N+L++++ ++K+ DFGLAK G+ + T T Y APE++ G Sbjct: 317 HRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTF-CGTLAYVAPEVIRGKDTSVS 375 Query: 190 ---------YGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Y VDMW++GC++ +L +PF S DQL ++ +G + + P Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL---YKQIGRGSYHEGP- 429 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 L D+ ++ D I L +P R TA +AL Sbjct: 430 ---LKDF----------------RISEEARDFIDSLLQVDPNNRSTAAKAL 461 >2Z7Q-A nrPDB Length = 321 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 70/233 (30%), Positives = 118/233 (50%), Gaps = 12/233 (5%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARD---KNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 K+ +E L LG+G F V+ R ++ + A+K +K + +D + R+ Sbjct: 24 KADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKA-TLKVRDRVRTKMERD 82 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I L +++HP ++ L AF + + L+ DF+ ++ T +K Y+ Sbjct: 83 I--LADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQVVTRWYRAP 181 GL++LH I++RDLKP N+LLDE G +KL DFGL+K + +AY+ T Y AP Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF-CGTVEYMAP 199 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFET-LGTP 232 E++ + + D W+ G ++ E+L +PF G + +T I + LG P Sbjct: 200 EVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF-QGKDRKETMTLILKAKLGMP 250 >3UDB-A nrPDB Length = 317 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 82/303 (27%), Positives = 133/303 (43%), Gaps = 43/303 (14%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M L + + RYE + +G G F RDK N++VA+K I+ G + I+ Sbjct: 10 MDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEK------IDENVK 63 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYM 118 REI + L HPNI+ + +++++V ++ E I N+ + + + Sbjct: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFF 121 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKS---FGSPNRAYTHQV 173 + G+ Y H + HRDLK N LLD + LK+ADFG +K+ P A V Sbjct: 122 QQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSA----V 177 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTP 232 T Y APE+L G D+W+ G L +L+ PF D ++ +T+ Sbjct: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF----EDPEEPKNFRKTIHRI 233 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 Q+ ++PDYV HI + LI +F+ +P RI+ + Sbjct: 234 LNVQY----AIPDYV-----------HI----SPECRHLISRIFVADPAKRISIPEIRNH 274 Query: 293 KYF 295 ++F Sbjct: 275 EWF 277 >3KK8-A nrPDB Length = 284 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 90/293 (30%), Positives = 135/293 (46%), Gaps = 38/293 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + K T A K I S A+D + RE ++ ++L H Sbjct: 8 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLS-ARDF--QKLEREARICRKLQH 64 Query: 72 PNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ L D+ +S LVFD + E +++ ++ SH + L+ + Y Sbjct: 65 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHC---IQQILESIAYC 121 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H + I+HR+LKP NLLL + +KLADFGLA + A+ T Y +PE+L Sbjct: 122 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVND-SEAWHGFAGTPGYLSPEVL- 179 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Y VD+WA G IL LL+ P D DQ R++ + + +P P+ Sbjct: 180 KKDPYSKPVDIWACGVILYILLVGYPPF---WDEDQ-HRLYAQIKAGAYD-YPS----PE 230 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + T + LI + NP RITA QALK+ + NR Sbjct: 231 WDTVTP---------------EAKSLIDSMLTVNPKKRITADQALKVPWICNR 268 >5UUU-A nrPDB Length = 547 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 63/194 (32%), Positives = 103/194 (53%), Gaps = 9/194 (4%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH---PNI 74 +G G F VY R +T ++ A+K + R + K G AL E +L +S P I Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLD-KKRIKMKQG-ETLALNERIMLSLVSTGDCPFI 263 Query: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 + + AF +S + D M DL + + V + + ++ Y + GLE++H ++ Sbjct: 264 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHMHNRFV 322 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 ++RDLKP N+LLDE+G ++++D GLA F S + + V T Y APE+L Y Sbjct: 323 VYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHA-SVGTHGYMAPEVLQKGVAYDSS 380 Query: 194 VDMWAVGCILAELL 207 D +++GC+L +LL Sbjct: 381 ADWFSLGCMLFKLL 394 >2BDW-A nrPDB Length = 362 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 90/293 (30%), Positives = 135/293 (46%), Gaps = 38/293 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + K T A K I S A+D + RE ++ ++L H Sbjct: 31 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLS-ARDF--QKLEREARICRKLQH 87 Query: 72 PNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI+ L D+ +S LVFD + E +++ ++ SH + L+ + Y Sbjct: 88 PNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHC---IQQILESIAYC 144 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H + I+HR+LKP NLLL + +KLADFGLA + A+ T Y +PE+L Sbjct: 145 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVND-SEAWHGFAGTPGYLSPEVL- 202 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Y VD+WA G IL LL+ P D DQ R++ + + +P P+ Sbjct: 203 KKDPYSKPVDIWACGVILYILLVGYPPF---WDEDQ-HRLYAQIKAGAYD-YPS----PE 253 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + T + LI + NP RITA QALK+ + NR Sbjct: 254 WDTVTP---------------EAKSLIDSMLTVNPKKRITADQALKVPWICNR 291 >5O0Y-A nrPDB Length = 579 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 80/248 (32%), Positives = 121/248 (48%), Gaps = 23/248 (9%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGH--RSEAKDGINRTALREIKLLQE 68 RY L LG G F+ VYKA D + VA+K +L R E K+ ++ A RE ++ +E Sbjct: 285 RYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKE 344 Query: 69 LSHPNIIGLLDAFG-HKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 L HP I+ L D F + V ++ E DL+ +K + L ++ ++ ++ + L+ Sbjct: 345 LDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKL-MSEKEARSIIMQIVNALK 403 Query: 127 YLHQHW--ILHRDLKPNNLLLDEN---GVLKLADFGLAK-----SFGSPN--RAYTHQVV 174 YL++ I+H DLKP N+LL G +K+ DFGL+K S+ S + + Sbjct: 404 YLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 463 Query: 175 TRWYRAPELLFGAR---MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLG 230 T WY PE + VD+W+VG I + L R PF S D L T+ Sbjct: 464 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQE--NTIL 521 Query: 231 TPTEEQWP 238 TE Q+P Sbjct: 522 KATEVQFP 529 >4AF3-A nrPDB Length = 292 Score = 88.6 bits (218), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 69/211 (32%), Positives = 100/211 (47%), Gaps = 5/211 (2%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G+F VY AR+K ++ IVA+K L K+G+ REI++ L HPNI+ L Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKV--LFKSQIEKEGVEHQLRREIEIQAHLHHPNILRL 88 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRD 137 + F + I L+ ++ S M L Y H ++HRD Sbjct: 89 YNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRD 148 Query: 138 LKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMW 197 +KP NLLL G LK+ADFG S +P+ T Y PE++ G RM+ VD+W Sbjct: 149 IKPENLLLGLKGELKIADFGW--SVHAPSLRRKTMCGTLDYLPPEMIEG-RMHNEKVDLW 205 Query: 198 AVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 +G + ELL+ P S + RI + Sbjct: 206 CIGVLCYELLVGNPPFESASHNETYRRIVKV 236 >3PVW-A nrPDB Length = 695 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 63/194 (32%), Positives = 103/194 (53%), Gaps = 9/194 (4%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH---PNI 74 +G G F VY R +T ++ A+K + R + K G AL E +L +S P I Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLD-KKRIKMKQG-ETLALNERIMLSLVSTGDCPFI 254 Query: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 + + AF +S + D M DL + + V + + ++ Y + GLE++H ++ Sbjct: 255 VCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG-VFSEADMRFYAAEIILGLEHMHNRFV 313 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 ++RDLKP N+LLDE+G ++++D GLA F S + + V T Y APE+L Y Sbjct: 314 VYRDLKPANILLDEHGHVRISDLGLACDF-SKKKPHA-SVGTHGYMAPEVLQKGVAYDSS 371 Query: 194 VDMWAVGCILAELL 207 D +++GC+L +LL Sbjct: 372 ADWFSLGCMLFKLL 385 >2F57-A nrPDB Length = 317 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 134/296 (45%), Gaps = 44/296 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG V A +K+T + VA+KK+ L + + N E+ ++++ H N++ + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN-----EVVIMRDYHHDNVVDM 107 Query: 78 LDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 ++ + +V +F+E TD+ + N I L L+ L YLH + Sbjct: 108 YSSYLVGDELWVVMEFLEGGALTDIVTHTRMNE-----EQIATVCLSVLRALSYLHNQGV 162 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM-YGV 192 +HRD+K +++LL +G +KL+DFG V T ++ APE++ +R+ YG Sbjct: 163 IHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI--SRLPYGT 220 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 VD+W++G ++ E++ P + L + RI + SLP Sbjct: 221 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD--------------SLP-------- 258 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 P + H S+ LDL + + P R TA + L F GP P C +P Sbjct: 259 PRVKDLHKVSSVLRGFLDL---MLVREPSQRATAQELLGHP-FLKLAGP-PSCIVP 309 >5YV8-A nrPDB Length = 298 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 111/228 (48%), Gaps = 25/228 (10%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSE----------------- 50 +Y D +G+G + V A ++N N A+K K KL ++ Sbjct: 14 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGC 73 Query: 51 -AKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV- 108 G +EI +L++L HPN++ L++ + L F + +++ +L Sbjct: 74 IQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKP 133 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 L+ + Y ++G+EYLH I+HRD+KP+NLL+ E+G +K+ADFG++ F + Sbjct: 134 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDAL 193 Query: 169 YTHQVVTRWYRAPELLFGAR--MYGVGVDMWAVGCILAELLL-RVPFL 213 ++ V T + APE L R G +D+WA+G L + + PF+ Sbjct: 194 LSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 241 >4NIF-A nrPDB Length = 333 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 81/292 (27%), Positives = 130/292 (44%), Gaps = 44/292 (15%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK-LLQELSHPNI 74 + +G G ++ + K TN A+K I D R EI+ LL+ HPNI Sbjct: 14 ETIGVGSYSECKRCVHKATNMEYAVKVI---------DKSKRDPSEEIEILLRYGQHPNI 64 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL-QGLEYLHQHWI 133 I L D + ++ LV + M E++ K +++L T+ + +EYLH + Sbjct: 65 ITLKDVYDDGKHVYLVTELMRGG-ELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 123 Query: 134 LHRDLKPNNLL-LDENG---VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 +HRDLKP+N+L +DE+G L++ DFG AK + N T + APE+L + Sbjct: 124 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL-KRQG 182 Query: 190 YGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQ--LTRIFETLGTPTEEQWPDMCSLPDY 246 Y G D+W++G +L +L PF G SD + LTRI T + W Sbjct: 183 YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW--------- 233 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + + DL+ + +P R+TA Q L+ + + + Sbjct: 234 ---------------NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQK 270 >2XIK-A nrPDB Length = 294 Score = 87.4 bits (215), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 107/216 (49%), Gaps = 11/216 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + KLD +G+G F VYK D +T ++VAIK I L + + I + EI +L + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQ----EITVLSQCDS 76 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEV-IIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P I ++ + + ++ +++ + ++K L T +I + L+GL+YLH Sbjct: 77 PYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEET--YIATILREILKGLDYLHS 134 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 +HRD+K N+LL E G +KLADFG+A V T ++ APE++ Y Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAY 193 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIF 226 D+W++G EL P +SDL + +F Sbjct: 194 DFKADIWSLGITAIEL---AKGEPPNSDLHPMRVLF 226 >3MV5-A nrPDB Length = 342 Score = 87.4 bits (215), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 103/219 (47%), Gaps = 5/219 (2%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A+D + +E L LG+G F V ++K T + A+K +K AKD + T L Sbjct: 2 AMDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK-KEVIVAKDEVAHT-LT 59 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E ++LQ HP + L +F + V ++ V + + Y Sbjct: 60 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 119 Query: 122 LQGLEYLH-QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + L+YLH + +++RDLK NL+LD++G +K+ DFGL K T Y A Sbjct: 120 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 179 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSD 218 PE+L YG VD W +G ++ E++ R+PF D + Sbjct: 180 PEVL-EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 217 >3ORZ-A nrPDB Length = 316 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 64/198 (32%), Positives = 97/198 (48%), Gaps = 9/198 (4%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LGEG F+TV AR+ T++ AIK ++ R K+ RE ++ L HP + L Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILE--KRHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 F + + + L+ I K S T + Y + LEYLH I+H Sbjct: 103 YFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRF--YTAEIVSALEYLHGKGIIH 160 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ--VVTRWYRAPELLFGARMYGVG 193 RDLKP N+LL+E+ +++ DFG AK ++ V T Y +PELL + Sbjct: 161 RDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL-TEKSACKS 219 Query: 194 VDMWAVGCILAELLLRVP 211 D+WA+GCI+ +L+ +P Sbjct: 220 SDLWALGCIIYQLVAGLP 237 >4PDS-A nrPDB Length = 347 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 81/300 (27%), Positives = 138/300 (46%), Gaps = 47/300 (15%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + +G+G FATV KA ++ T + ++K I DG+ R E+++LQ+L+HP I+ Sbjct: 37 EVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTR----ELEVLQKLNHPRIV 92 Query: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + + +V +F+ DL + + V + + L ++Y+H I Sbjct: 93 RLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAG-REISRQILTAIKYIHSMGIS 151 Query: 135 HRDLKPNNLLLDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM--- 189 HRDLKP+N+L++++ ++K+ FGLAK G+ + T T Y APE++ G Sbjct: 152 HRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTF-CGTLAYVAPEVIRGKDTSVS 210 Query: 190 ---------YGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Y VDMW++GC++ +L +PF S DQL ++ +G + + P Sbjct: 211 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPF--SGSTQDQL---YKQIGRGSYHEGP- 264 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 L D+ ++ D I L +P R TA +AL + P Sbjct: 265 ---LKDF----------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSP 305 >4CQG-A nrPDB Length = 331 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/218 (32%), Positives = 100/218 (45%), Gaps = 11/218 (5%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D K YE + +G G FA V A T ++VAIK + ++ + R EI Sbjct: 3 DYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMD---KNALGSDLPRVK-TEI 58 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 L+ L H +I L K+ I +V ++ + II + L + + Sbjct: 59 DALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRL--SEEETRVVFRQI 116 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGL-AKSFGSPNRAYTHQVVTRWYRA 180 L + Y+H HRDLKP NLL DEN LKL DFGL AK G+ + + Y A Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAA 176 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 PEL+ G G D+W++G +L +L FLP D D Sbjct: 177 PELIQGKSYLGSEADVWSMGILL--YVLMCGFLPFDDD 212 >2OU7-A nrPDB Length = 335 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 124/283 (43%), Gaps = 35/283 (12%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKI--KLGHRSEAKDGINRTALREIKLLQELSHPNI 74 FLG+G FA ++ D +T ++ A K + L + ++ ++ EI + + L+H ++ Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM----EISIHRSLAHQHV 103 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 +G F + +V + + + LT + Y+ + G +YLH++ ++ Sbjct: 104 VGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 163 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGV 194 HRDLK NL L+E+ +K+ DFGLA T Y APE+L + + V Sbjct: 164 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEV 222 Query: 195 DMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG 254 D+W++GCI+ LL+ P FET C Y+ K Sbjct: 223 DVWSIGCIMYTLLVGKP-------------PFET-----------SCLKETYLRIKKNEY 258 Query: 255 IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 HI A LIQ + +P AR T + L ++F++ Sbjct: 259 SIPKHINPVAA----SLIQKMLQTDPTARPTINELLNDEFFTS 297 >6CQF-A nrPDB Length = 297 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 103/207 (49%), Gaps = 9/207 (4%) Query: 4 DVKSRAKR--YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 D+ +R R Y+ L LG G + V+KARDK + +VA+K +K+ E D ++ T + Sbjct: 8 DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM----EPDDDVS-TLQK 62 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 EI +L+ H NI+ ++ + + +F I + L+ I Sbjct: 63 EILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREV 122 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 LQGL YLH +HRD+K N+L+++ G ++LADFG++ G+ + T ++ AP Sbjct: 123 LQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAP 182 Query: 182 ELLFGARMYGVG--VDMWAVGCILAEL 206 E+ A G D+W++G EL Sbjct: 183 EVAAVALKGGYNELCDIWSLGITAIEL 209 >3ZUT-A nrPDB Length = 362 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 133/300 (44%), Gaps = 37/300 (12%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M L + + RYE + +G G F RDK +N++VA+K I+ G + I+ Sbjct: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEK------IDENVK 63 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYM 118 REI + L HPNI+ + +++++V ++ E I N+ + + + Sbjct: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC--NAGRFSEDEARFFF 121 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTR 176 + G+ Y H + HRDLK N LLD + LK+ FG +KS ++ + V T Sbjct: 122 QQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKS-TVGTP 180 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEE 235 Y APE+L G D+W+ G L +L+ PF D ++ +T+ Sbjct: 181 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF----EDPEEPKNFRKTIHRILNV 236 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 Q+ ++PDYV HI + LI +F+ +P RI+ + ++F Sbjct: 237 QY----AIPDYV-----------HI----SPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >4CSV-A nrPDB Length = 275 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 108/218 (49%), Gaps = 18/218 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF VY+ + +N N VA+K +K G S + L+E +++++L HPN++ L Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE------FLQEAQIMKKLKHPNLVQL 72 Query: 78 LDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + I ++ ++M + L+ + + + G+ YL +H Sbjct: 73 YGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIH 132 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 RDL N L+ EN V+K+ADFGLA+ YT + ++ + APE + R + + Sbjct: 133 RDLAARNCLVGENNVVKVADFGLARLINEDE--YTARAGAKFPIKWTAPEAISYNR-FSI 189 Query: 193 GVDMWAVGCILAELLL--RVPF--LPGDSDLDQLTRIF 226 D+WA G +L E+ +VP+ + G ++Q+ R + Sbjct: 190 KSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGY 227 >4J52-A nrPDB Length = 293 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 124/283 (43%), Gaps = 35/283 (12%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKI--KLGHRSEAKDGINRTALREIKLLQELSHPNI 74 FLG+G FA ++ D +T ++ A K + L + ++ ++ EI + + L+H ++ Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM----EISIHRSLAHQHV 76 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 +G F + +V + + + LT + Y+ + G +YLH++ ++ Sbjct: 77 VGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVI 136 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGV 194 HRDLK NL L+E+ +K+ DFGLA T Y APE+L + + V Sbjct: 137 HRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEV 195 Query: 195 DMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG 254 D+W++GCI+ LL+ P FET C Y+ K Sbjct: 196 DVWSIGCIMYTLLVGKP-------------PFET-----------SCLKETYLRIKKNEY 231 Query: 255 IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 HI A LIQ + +P AR T + L ++F++ Sbjct: 232 SIPKHINPVAA----SLIQKMLQTDPTARPTINELLNDEFFTS 270 >5HVK-A nrPDB Length = 315 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 111/227 (48%), Gaps = 26/227 (11%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG+G F K + T +++ +K++ + RT L+E+K+++ L HPN++ Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKEL-----IRFDEETQRTFLKEVKVMRCLEHPNVL 74 Query: 76 GLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + ++ + ++++ L IIK S ++ G+ YLH I+ Sbjct: 75 KFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNII 134 Query: 135 HRDLKPNNLLLDENGVLKLADFGLA-------------KSFGSPNRAYTHQVVTR-WYRA 180 HR+L +N L+ EN + +ADFGLA +S P+R + VV ++ A Sbjct: 135 HRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 PE++ G R Y VD+++ G +L E++ RV ++D D L R + Sbjct: 195 PEMING-RSYDEKVDVFSFGIVLCEIIGRV-----NADPDYLPRTMD 235 >5JZN-A nrPDB Length = 280 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 107/216 (49%), Gaps = 16/216 (7%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +RY+ +G+G FA V + +++T + A+K IK +S+ + G E+ +L+ Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIK---KSKCR-GKEHMIQNEVSILRR 73 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + HPNI+ L++ + + LV + ++ + I N + Y L + ++ Sbjct: 74 VKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLAS--AIK 131 Query: 127 YLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 YLH I+HRD+KP NLL+ D + LKL DFGLA P YT T Y APE Sbjct: 132 YLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP--LYT-VCGTPTYVAPE 188 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 ++ YG+ VD+WA G I LL P G D Sbjct: 189 II-AETGYGLKVDIWAAGVITYILLCGFPPFRGSGD 223 >1FOT-A nrPDB Length = 318 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 12/205 (5%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIK--LGHRSEAKDGINRTALREI 63 K + ++ L LG G F V+ R ++ + A+K +K + R + + N L Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERL--- 58 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTL 122 +L ++HP II + F I ++ D++E +L +++ + P K Y Sbjct: 59 -MLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPV-AKFYAAEVC 116 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 LEYLH I++RDLKP N+LLD+NG +K+ DFG AK P+ YT T Y APE Sbjct: 117 LALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV--PDVTYT-LCGTPDYIAPE 173 Query: 183 LLFGARMYGVGVDMWAVGCILAELL 207 ++ + Y +D W+ G ++ E+L Sbjct: 174 VV-STKPYNKSIDWWSFGILIYEML 197 >3BHH-A nrPDB Length = 295 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 85/298 (28%), Positives = 131/298 (43%), Gaps = 37/298 (12%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 S Y+ + +G+G F+ V + T A K I S A+D ++ RE ++ Sbjct: 1 SMTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLS-ARD--HQKLEREARIC 57 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + L H NI+ L D+ + LVFD + E +++ ++ SH + L+ Sbjct: 58 RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHC---IQQILE 114 Query: 124 GLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + + HQ ++HRDLKP NLLL + +KLADFGLA +A+ T Y + Sbjct: 115 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE+L YG VD+WA G IL LL+ P D DQ ++++ + + Sbjct: 175 PEVL-RKEAYGKPVDIWACGVILYILLVGYPPF---WDEDQ-HKLYQQIKAGAYD----- 224 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + A +LI + NP RITA +ALK + R Sbjct: 225 -----------FPSPEWDTVTPEAK----NLINQMLTINPAKRITAHEALKHPWVCQR 267 >2JC6-A nrPDB Length = 334 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 81/295 (27%), Positives = 125/295 (42%), Gaps = 40/295 (13%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A D+K K +E + LG G F+ V A +K T ++ A+K I +A G + Sbjct: 17 AEDIK---KIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIP----KKALKGKESSIEN 69 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYML 119 EI +L+++ H NI+ L D + +++ LV + + I++ T + Sbjct: 70 EIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIR 127 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 L + YLH+ I+HRDLKP NLL DE + ++DFGL+K G + T T Sbjct: 128 QVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST-ACGTP 186 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 Y APE+L + Y VD W++G I LL P ++D +I + Sbjct: 187 GYVAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPY 245 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 W D+ D D I+ L +P R T QA + Sbjct: 246 WDDI------------------------SDSAKDFIRNLMEKDPNKRYTCEQAAR 276 >4FIE-A nrPDB Length = 423 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 17/195 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG V A +++ ++VA+KK+ L + + N E+ ++++ H N++ + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-----EVVIMRDYQHENVVEM 213 Query: 78 LDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +++ + +V +F+E TD+ + N I A L LQ L LH + Sbjct: 214 YNSYLVGDELWVVMEFLEGGALTDIVTHTRMNE-----EQIAAVCLAVLQALSVLHAQGV 268 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM-YGV 192 +HRD+K +++LL +G +KL+DFG V T ++ APEL+ +R+ YG Sbjct: 269 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI--SRLPYGP 326 Query: 193 GVDMWAVGCILAELL 207 VD+W++G ++ E++ Sbjct: 327 EVDIWSLGIMVIEMV 341 >5B2L-A nrPDB Length = 324 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 107/221 (48%), Gaps = 10/221 (4%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 E L +G G V+K R + T ++A+K+++ RS K+ R + +L+ P Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMR---RSGNKEENKRILMDLDVVLKSHDCP 76 Query: 73 NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL-HQH 131 I+ F +++ + + M T E + K + + + ++ L YL +H Sbjct: 77 YIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKH 136 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF----GA 187 ++HRD+KP+N+LLDE G +KL DFG++ ++A T Y APE + Sbjct: 137 GVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPERIDPPDPTK 195 Query: 188 RMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFE 227 Y + D+W++G L EL + P+ +D + LT++ + Sbjct: 196 PDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ 236 >3C51-A nrPDB Length = 543 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 71/206 (34%), Positives = 105/206 (50%), Gaps = 12/206 (5%) Query: 15 LDF--LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LDF LG G F V+ + K T ++ A KK+ + K + A+ E K+L ++ Sbjct: 188 LDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKG--YQGAMVEKKILAKVHSR 245 Query: 73 NIIGLLDAFGHKSNISLVFDFMET-DLEVII----KDNSLVLTPSHIKAYMLMTLQGLEY 127 I+ L AF K+++ LV M D+ I +DN P I Y + GLE+ Sbjct: 246 FIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAI-FYTAQIVSGLEH 304 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 LHQ I++RDLKP N+LLD++G ++++D GLA + T + APELL G Sbjct: 305 LHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGE 364 Query: 188 RMYGVGVDMWAVGCILAELL-LRVPF 212 Y VD +A+G L E++ R PF Sbjct: 365 E-YDFSVDYFALGVTLYEMIAARGPF 389 >2Q0N-A nrPDB Length = 301 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 17/195 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG V A +++ ++VA+KK+ L + + N E+ ++++ H N++ + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-----EVVIMRDYQHENVVEM 91 Query: 78 LDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +++ + +V +F+E TD+ + N I A L LQ L LH + Sbjct: 92 YNSYLVGDELWVVMEFLEGGALTDIVTHTRMNE-----EQIAAVCLAVLQALSVLHAQGV 146 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM-YGV 192 +HRD+K +++LL +G +KL+DFG V T ++ APEL+ +R+ YG Sbjct: 147 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI--SRLPYGP 204 Query: 193 GVDMWAVGCILAELL 207 VD+W++G ++ E++ Sbjct: 205 EVDIWSLGIMVIEMV 219 >3KN6-A nrPDB Length = 325 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 85/277 (30%), Positives = 121/277 (43%), Gaps = 36/277 (12%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LGEG F+ K K +NQ A+K I R EA TAL+ + HPNI+ L Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKII--SKRMEANTQKEITALKLCE-----GHPNIVKL 71 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTL-QGLEYLHQHWIL 134 + F + + LV + + E I K T + +Y++ L + ++H ++ Sbjct: 72 HEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEA---SYIMRKLVSAVSHMHDVGVV 128 Query: 135 HRDLKPNNLLL-DENGVL--KLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 HRDLKP NLL DEN L K+ DFG A+ N+ T Y APELL Y Sbjct: 129 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYD 187 Query: 192 VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 D+W++G IL +L +VPF D L T E + + + Sbjct: 188 ESCDLWSLGVILYTMLSGQVPFQSHDRSL-TCTSAVEIMKKIKKGDF------------- 233 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287 SF G ++ A DLIQGL +P R+ + Sbjct: 234 SFEGEAWKNVSQEAK----DLIQGLLTVDPNKRLKMS 266 >4JDH-A nrPDB Length = 346 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 17/195 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG V A +++ ++VA+KK+ L + + N E+ ++++ H N++ + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-----EVVIMRDYQHENVVEM 136 Query: 78 LDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +++ + +V +F+E TD+ + N I A L LQ L LH + Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTDIVTHTRMNE-----EQIAAVCLAVLQALSVLHAQGV 191 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM-YGV 192 +HRD+K +++LL +G +KL+DFG V T ++ APEL+ +R+ YG Sbjct: 192 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI--SRLPYGP 249 Query: 193 GVDMWAVGCILAELL 207 VD+W++G ++ E++ Sbjct: 250 EVDIWSLGIMVIEMV 264 >5KCV-A nrPDB Length = 460 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 5/209 (2%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E L LG+G F V ++K T + A+K +K AKD + T L E ++LQ H Sbjct: 164 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILK-KEVIVAKDEVAHT-LTENRVLQNSRH 221 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH-Q 130 P + L +F + V ++ V + + Y + L+YLH + Sbjct: 222 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSE 281 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 +++RDLK NL+LD++G +K+ DFGL K T Y APE+L Y Sbjct: 282 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL-EDNDY 340 Query: 191 GVGVDMWAVGCILAELLL-RVPFLPGDSD 218 G VD W +G ++ E++ R+PF D + Sbjct: 341 GRAVDWWGLGVVMYEMMCGRLPFYNQDHE 369 >4XBR-A nrPDB Length = 366 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 17/195 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG V A +++ ++VA+KK+ L + + N E+ ++++ H N++ + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-----EVVIMRDYQHENVVEM 156 Query: 78 LDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +++ + +V +F+E TD+ + N I A L LQ L LH + Sbjct: 157 YNSYLVGDELWVVMEFLEGGALTDIVTHTRMNE-----EQIAAVCLAVLQALSVLHAQGV 211 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM-YGV 192 +HRD+K +++LL +G +KL+DFG V T ++ APEL+ +R+ YG Sbjct: 212 IHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI--SRLPYGP 269 Query: 193 GVDMWAVGCILAELL 207 VD+W++G ++ E++ Sbjct: 270 EVDIWSLGIMVIEMV 284 >4WNO-A nrPDB Length = 287 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 106/212 (50%), Gaps = 17/212 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQI-VAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 + + D +G G FA V+K R + + + VA+K I + ++++ + + EIK+L+EL Sbjct: 20 FSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGK----EIKILKELK 75 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 H NI+ L D +++ LV ++ L+ I+ ++ + LH Sbjct: 76 HENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS 135 Query: 131 HWILHRDLKPNNLLLDE--------NGV-LKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 I+HRDLKP N+LL N + +K+ADFG A+ S A T + Y AP Sbjct: 136 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMAP 194 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 E++ ++ Y D+W++G I+ + L + PF Sbjct: 195 EVIM-SQHYDGKADLWSIGTIVYQCLTGKAPF 225 >3HDN-A nrPDB Length = 373 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 98/206 (47%), Gaps = 4/206 (1%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 ++ + L +G+G F V AR K A+K ++ + K+ + + R + LL Sbjct: 35 AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV-LL 93 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 + + HP ++GL +F + V D++ +L ++ L P + Y L Sbjct: 94 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP-RARFYAAEIASAL 152 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 YLH I++RDLKP N+LLD G + L DFGL K N + T Y APE+L Sbjct: 153 GYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLH 212 Query: 186 GARMYGVGVDMWAVGCILAELLLRVP 211 + Y VD W +G +L E+L +P Sbjct: 213 -KQPYDRTVDWWCLGAVLYEMLYGLP 237 >5UNP-A nrPDB Length = 369 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 83/341 (24%), Positives = 144/341 (42%), Gaps = 59/341 (17%) Query: 10 KRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +RYE + LGEG F V + D + VA+K IK + A EI +L++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK------NVEKYKEAARLEINVLEK 87 Query: 69 LSHPN------IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + + + D F + ++ + F+ + +KDN+ + P H +M L Sbjct: 88 INEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 123 -QGLEYLHQHWILHRDLKPNNLLL---------------DENGV----LKLADFGLAKSF 162 Q +++LH + + H DLKP N+L DE V +++ DFG A +F Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA-TF 206 Query: 163 GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL 222 + + V TR YRAPE++ + D+W++GCI+ E + + + L Sbjct: 207 DHEHHSTI--VSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHL 263 Query: 223 TRIFETLG-------TPTEEQ---------WPDMCSLPDYVTFKSFPGIPLHHIFSAAGD 266 + LG T +Q W + S YV PL ++ + Sbjct: 264 AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENC---KPLRRYLTSEAE 320 Query: 267 D---LLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304 + L DLI+ + + P R+T +AL+ +F+ P Sbjct: 321 EHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 >4JG6-A nrPDB Length = 355 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 86/338 (25%), Positives = 142/338 (42%), Gaps = 47/338 (13%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK-LLQELS 70 YE + +G G ++ + K TN A+K I D R EI+ LL+ Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKII---------DKSKRDPTEEIEILLRYGQ 87 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HPNII L D + + +V + M+ L+ I++ + A + + +EYL Sbjct: 88 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVLFTITKTVEYL 145 Query: 129 HQHWILHRDLKPNNLL-LDENG---VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 H ++HRDLKP+N+L +DE+G +++ DFG AK + N T + APE+L Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 185 FGARMYGVGVDMWAVGCILAELLL-RVPFL--PGDSDLDQLTRIFETLGTPTEEQWPDMC 241 + Y D+W++G +L +L PF P D+ + L RI + + W Sbjct: 206 -ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW---- 260 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 ++ D DL+ + +P R+TA L+ + + Sbjct: 261 --------------------NSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHW-DQ 299 Query: 302 TPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGG 339 P QL R + P + A+ R ++ LE G Sbjct: 300 LPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVG 337 >3HKO-A nrPDB Length = 345 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 114/268 (42%), Gaps = 55/268 (20%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR---EIKLL 66 K+Y +G+G + V A + NQ AI+ IK+ ++++ + + R E++L+ Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIE---NQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLM 82 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFME-----TDLEVIIKDNS--------------- 106 ++L HPNI L + + + I LV + L V I D++ Sbjct: 83 KKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPC 142 Query: 107 --------------------LVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD 146 V I M L YLH I HRD+KP N L Sbjct: 143 PECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFS 202 Query: 147 ENGV--LKLADFGLAKSFGSPNRAYTHQVVTR----WYRAPELLFGA-RMYGVGVDMWAV 199 N +KL DFGL+K F N + + T+ ++ APE+L YG D W+ Sbjct: 203 TNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSA 262 Query: 200 GCILAELLL-RVPFLPGDSDLDQLTRIF 226 G +L LL+ VPF PG +D D ++++ Sbjct: 263 GVLLHLLLMGAVPF-PGVNDADTISQVL 289 >1ZXE-A nrPDB Length = 303 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 71/246 (28%), Positives = 112/246 (45%), Gaps = 38/246 (15%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A +E++ LG+G F V KAR+ ++ AIKKI+ H E T L E+ LL Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR--HTEEKLS----TILSEVMLLAS 58 Query: 69 LSHP-------------NIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHI 114 L+H N + + A KS + + ++ E L +I +L Sbjct: 59 LNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEY 118 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF------------ 162 L+ L Y+H I+HR+LKP N+ +DE+ +K+ DFGLAK+ Sbjct: 119 WRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQ 178 Query: 163 ---GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDL 219 GS + T + T Y A E+L G Y +DM+++G I E++ PF G + Sbjct: 179 NLPGSSDNL-TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY--PFSTGMERV 235 Query: 220 DQLTRI 225 + L ++ Sbjct: 236 NILKKL 241 >3ALO-A nrPDB Length = 327 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/229 (29%), Positives = 114/229 (49%), Gaps = 15/229 (6%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A+ + L +G G + +V K K + QI+A+K+I RS + + L ++ ++ Sbjct: 21 AEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI----RSTVDEKEQKQLLMDLDVVMR 76 Query: 69 LSH-PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVL---TPSHIKAYM-LMTLQ 123 S P I+ A + + + + M T + K VL P I + L T++ Sbjct: 77 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK 136 Query: 124 GLEYLHQHW-ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 L +L ++ I+HRD+KP+N+LLD +G +KL DFG++ + A T R Y APE Sbjct: 137 ALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVD-SIAKTRDAGCRPYMAPE 195 Query: 183 LL---FGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFE 227 + + Y V D+W++G L EL R P+ +S DQLT++ + Sbjct: 196 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 244 >4CFF-A nrPDB Length = 571 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/224 (30%), Positives = 104/224 (46%), Gaps = 32/224 (14%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + Y D LG G F V + T VA+K + + + D + + REI Sbjct: 27 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIK-REI 84 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLM- 120 + L+ HP+II L ++ +V +++ + I K + ++A L Sbjct: 85 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV----EEMEARRLFQ 140 Query: 121 -TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAY 169 L ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ S GSPN Sbjct: 141 QILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN--- 197 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 Y APE++ G G VD+W+ G IL LL +PF Sbjct: 198 --------YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 233 >4C59-A nrPDB Length = 340 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 110/226 (48%), Gaps = 33/226 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNIIG 76 L EG FA VY+A+D + + A+K++ L + E NR ++E+ +++LS HPNI+ Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALKRL-LSNEEEK----NRAIIQEVCFMKKLSGHPNIVQ 89 Query: 77 LLDAFG--------HKSNISLVFDFMETDLEVIIK--DNSLVLTPSHIKAYMLMTLQGLE 126 A ++ L+ + + L +K ++ L+ + T + ++ Sbjct: 90 FCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 149 Query: 127 YLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAK--------SFGSPNRAYTHQVVTR 176 ++H+ I+HRDLK NLLL G +KL DFG A S+ + RA + +TR Sbjct: 150 HMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITR 209 Query: 177 ----WYRAPEL--LFGARMYGVGVDMWAVGCILAELLLRV-PFLPG 215 YR PE+ L+ G D+WA+GCIL L R PF G Sbjct: 210 NTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDG 255 >6CCF-A nrPDB Length = 290 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 50/158 (31%), Positives = 84/158 (53%), Gaps = 6/158 (3%) Query: 61 REIKLLQELSHPNIIGLLDAFGH--KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYM 118 +EI +L++L H N++ L++ + N+ LVFD + V+ + + Y+ Sbjct: 77 QEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG-PVMEVPCDKPFSEEQARLYL 135 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + GLEYLH I+HRD+KP+NLLL ++G +K+ADFG++ F + + T + Sbjct: 136 RDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAF 195 Query: 179 RAPELL--FGARMYGVGVDMWAVGCILAELLL-RVPFL 213 APE + G G +D+WA G L + + PF+ Sbjct: 196 MAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI 233 >3QGY-A nrPDB Length = 286 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 102/201 (50%), Gaps = 16/201 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G GQF V+ N ++ VAIK IK G SE + E +++ +LSHP ++ L Sbjct: 35 IGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSEDD------FIEEAEVMMKLSHPKLVQL 87 Query: 78 LDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 ++ I LVF+FME L ++ + + L +G+ YL + ++HR Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHR 147 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGVG 193 DL N L+ EN V+K++DFG+ + + YT T++ + +PE+ +R Y Sbjct: 148 DLAARNCLVGENQVIKVSDFGMTRFV--LDDQYTSSTGTKFPVKWASPEVFSFSR-YSSK 204 Query: 194 VDMWAVGCILAELLL--RVPF 212 D+W+ G ++ E+ ++P+ Sbjct: 205 SDVWSFGVLMWEVFSEGKIPY 225 >3UC3-A nrPDB Length = 361 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 80/318 (25%), Positives = 129/318 (40%), Gaps = 39/318 (12%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ + +G G F RDK T ++VA+K I+ G I+ REI + Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA------AIDENVQREIINHRS 72 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ + ++++++ ++ N+ + + + L G+ Y Sbjct: 73 LRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 Query: 129 HQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I HRDLK N LLD + LK+ DFG +KS ++ + V T Y APE+L Sbjct: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLR 191 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G D+W+ G L +L+ PF + D I L S+PD Sbjct: 192 QEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKY--------SIPD 243 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-SNRPG---- 300 + + LI +F+ +P RI+ + +F N P Sbjct: 244 DIRISP---------------ECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMN 288 Query: 301 -PTPGCQLPRPNCPVETL 317 G Q P P+++L Sbjct: 289 ESNTGSQFQEPEQPMQSL 306 >5EZV-A nrPDB Length = 560 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 97/210 (46%), Gaps = 28/210 (13%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG G F V + T VA+K + + + D + + REI+ L+ HP+II Sbjct: 34 DTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIK-REIQNLKLFRHPHII 91 Query: 76 GLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 L ++ +V +++ + I K + + L ++Y H+H + Sbjct: 92 KLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV--EEMEARRLFQQILSAVDYCHRHMV 149 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTHQVVTRWYRAPEL 183 +HRDLKP N+LLD + K+ADFGL+ S GSPN Y APE+ Sbjct: 150 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN-----------YAAPEV 198 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPF 212 + G G VD+W+ G IL LL +PF Sbjct: 199 ISGRLYAGPEVDIWSCGVILYALLCGTLPF 228 >4E93-A nrPDB Length = 377 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 56/192 (29%), Positives = 90/192 (46%), Gaps = 10/192 (5%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F V+ R + N +VA+K R + L+E ++L++ SHPNI+ L Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSC----RETLPPDLKAKFLQEARILKQYSHPNIVRL 177 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + K I +V + ++ D ++ L + + G+EYL +HR Sbjct: 178 IGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHR 237 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPELLFGARMYGVG 193 DL N L+ E VLK++DFG+++ A + QV +W APE L R Y Sbjct: 238 DLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPEALNYGR-YSSE 295 Query: 194 VDMWAVGCILAE 205 D+W+ G +L E Sbjct: 296 SDVWSFGILLWE 307 >4WB7-A nrPDB Length = 405 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 22/225 (9%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 ++E++ LG G F V + K T A+K + + K I T L E ++LQ ++ Sbjct: 97 QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQ-IEHT-LNEKRILQAVN 154 Query: 71 HPNIIGLLDAFGHKSNISLVFDF-----METDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 P ++ L +F SN+ +V ++ M + L I + + H + Y + Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR-----FSEPHARFYAAQIVLTF 209 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 EYLH +++RDLKP NLL+D+ G +++ DFG AK R +T T Y APE++ Sbjct: 210 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWT-LCGTPEYLAPEIIL 266 Query: 186 GARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETL 229 ++ Y VD WA+G ++ E+ PF DQ +I+E + Sbjct: 267 -SKGYNKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQIYEKI 305 >6DBN-A nrPDB Length = 316 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 78/283 (27%), Positives = 125/283 (44%), Gaps = 37/283 (13%) Query: 18 LGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA--LREIKLLQELSH 71 LGEG F V Y NT + VA+K +K + G N A +EI++L+ L H Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLK------PESGGNHIADLKKEIEILRNLYH 96 Query: 72 PNII---GLLDAFGHKSNISLVFDFMETDL--EVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 NI+ G+ G + I L+ +F+ + E + K+ + + +K Y + +G++ Sbjct: 97 ENIVKYKGICTEDG-GNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLK-YAVQICKGMD 154 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAPE 182 YL +HRDL N+L++ +K+ DFGL K+ + YT WY APE Sbjct: 155 YLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APE 213 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 L ++ Y + D+W+ G L ELL DSD + + +G PT Q Sbjct: 214 CLMQSKFY-IASDVWSFGVTLHELLTYC-----DSDSSPMALFLKMIG-PTHGQMTVTRL 266 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 + K P P D++ L++ + F P R + Sbjct: 267 VNTLKEGKRLPCPP------NCPDEVYQLMRKCWEFQPSNRTS 303 >2YZA-A nrPDB Length = 276 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 101/222 (45%), Gaps = 28/222 (12%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + Y D LG G F V + T VA+K + + + D + + REI Sbjct: 5 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR-QKIRSLDVVGKIK-REI 62 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 + L+ HP+II L ++ +V +++ + I K + + Sbjct: 63 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRV--EEMEARRLFQQI 120 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK----------SFGSPNRAYTH 171 L ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ S GSPN Sbjct: 121 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPN----- 175 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 Y APE++ G G VD+W+ G IL LL +PF Sbjct: 176 ------YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 211 >4QMW-A nrPDB Length = 310 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 55/195 (28%), Positives = 97/195 (49%), Gaps = 6/195 (3%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + KL+ +G+G F V+K D T ++VAIK I L + + I + EI +L + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQ----EITVLSQCDS 86 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P + ++ + + ++ +++ + + + L + I + L+GL+YLH Sbjct: 87 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPG-PLDETQIATILREILKGLDYLHSE 145 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 +HRD+K N+LL E+G +KLADFG+A V T ++ APE++ Y Sbjct: 146 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-KQSAYD 204 Query: 192 VGVDMWAVGCILAEL 206 D+W++G EL Sbjct: 205 SKADIWSLGITAIEL 219 >6J5U-C nrPDB Length = 426 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 66/219 (30%), Positives = 111/219 (50%), Gaps = 21/219 (9%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYK---------ARDKNTNQIVAIKKIKLGHRSEAKDG 54 ++K+ K + + + LGEG F V+K A + +VA+K++K E G Sbjct: 78 ELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK----PEGFQG 133 Query: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEV-IIKDNSLVLTPS 112 ++ L E+ L +LSHPN++ L+ N LV++FM + LE + + + LT + Sbjct: 134 -HKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWA 192 Query: 113 HIKAYMLMTLQGLEYLHQ--HWILHRDLKPNNLLLDENGVLKLADFGLAKS--FGSPNRA 168 + +GL +LH+ +++RD K N+LLD + KL+DFGLAK+ G Sbjct: 193 IRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHV 252 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 T + T Y APE + R+ D+++ G +L EL+ Sbjct: 253 STKVIGTHGYAAPEYVATGRLTAKS-DVYSFGVVLLELI 290 >5N23-A nrPDB Length = 352 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 105/220 (47%), Gaps = 15/220 (6%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 ++E++ LG G F V + K T A+K + + K I T L E ++ Q ++ Sbjct: 43 QFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQ-IEHT-LNEKRIQQAVN 100 Query: 71 HPNIIGLLDAFGHKSNISLVFDF-----METDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 P ++ L +F SN+ +V ++ M + L I + + H + Y + Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGR-----FSEPHARFYAAQIVLTF 155 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 EYLH +++RDLKP NLL+D+ G +K+ADFG AK R T Y APE++ Sbjct: 156 EYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRV--KGRTPWTLCGTPEYLAPEIIL 213 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 ++ Y VD WA+G ++ E+ P D + +I Sbjct: 214 -SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 252 >2A1A-B nrPDB Length = 284 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 103/214 (48%), Gaps = 29/214 (13%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +++++ +G G F V+KA+ + + IK++K N A RE+K L +L H Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN---------NEKAEREVKALAKLDH 63 Query: 72 PNII---GLLDAFGH----------KSNISLVFDFME-----TDLEVIIKDNSLVLTPSH 113 NI+ G D F + +S +F ME T + I K L Sbjct: 64 VNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVL 123 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV 173 +G++Y+H +++RDLKP+N+ L + +K+ DFGL S + + + Sbjct: 124 ALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKG 183 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 R Y +PE + ++ YG VD++A+G ILAELL Sbjct: 184 TLR-YMSPEQI-SSQDYGKEVDLYALGLILAELL 215 >1FVR-A nrPDB Length = 327 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/211 (29%), Positives = 102/211 (48%), Gaps = 25/211 (11%) Query: 16 DFLGEGQFATVYKARDKNTN--QIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH-P 72 D +GEG F V KAR K AIK++K +KD +R E+++L +L H P Sbjct: 31 DVIGEGNFGQVLKARIKKDGLRMDAAIKRMK---EYASKDD-HRDFAGELEVLCKLGHHP 86 Query: 73 NIIGLLDAFGHKSNISLVFDF---------------METDLEVIIKDNSL-VLTPSHIKA 116 NII LL A H+ + L ++ +ETD I +++ L+ + Sbjct: 87 NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 146 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 + +G++YL Q +HRDL N+L+ EN V K+ADFGL++ + ++ R Sbjct: 147 FAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVR 206 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELL 207 W L + +Y D+W+ G +L E++ Sbjct: 207 WMAIESLNYS--VYTTNSDVWSYGVLLWEIV 235 >6E9W-A nrPDB Length = 443 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 103/217 (47%), Gaps = 14/217 (6%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTAL 60 D++ +A+ YE + +G G F V R K+T ++ A+K K ++ RS++ Sbjct: 96 DLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSA-----FFW 150 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 E ++ + P ++ L AF + +V ++M V + N V + Y Sbjct: 151 EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAE 209 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYR 179 + L+ +H +HRD+KP+N+LLD++G LKLADFG V T Y Sbjct: 210 VVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYI 269 Query: 180 APELL---FGARMYGVGVDMWAVGCILAELLL-RVPF 212 +PE+L G YG D W+VG L E+L+ PF Sbjct: 270 SPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPF 306 >2JAM-A nrPDB Length = 304 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 72/246 (29%), Positives = 115/246 (46%), Gaps = 30/246 (12%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 ++ LG G F+ V+ + + T ++ A+K IK +S A + + EI +L+++ H NI Sbjct: 14 MEVLGSGAFSEVFLVKQRLTGKLFALKCIK---KSPAFR--DSSLENEIAVLKKIKHENI 68 Query: 75 IGLLDAFGHKSNISLV---------FDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 + L D + ++ LV FD + KD SLV+ L + Sbjct: 69 VTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQ---------QVLSAV 119 Query: 126 EYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +YLH++ I+HRDLKP NLL +EN + + DFGL+K N + T Y APE Sbjct: 120 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM--EQNGIMSTACGTPGYVAPE 177 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC- 241 +L + Y VD W++G I LL P +++ +I E W D+ Sbjct: 178 VL-AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISE 236 Query: 242 SLPDYV 247 S D++ Sbjct: 237 SAKDFI 242 >2R2P-A nrPDB Length = 295 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 97/198 (48%), Gaps = 14/198 (7%) Query: 18 LGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 +G G+F V R K + VAIK +K+G+ + + R L E ++ + HPNI Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQR----RDFLGEASIMGQFDHPNI 85 Query: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 I L + +V ++ME L+ +K N T + + G++YL Sbjct: 86 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGY 145 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTH---QVVTRWYRAPELLFGARM 189 +HRDL N+L++ N V K++DFGL++ P AYT ++ RW APE + R Sbjct: 146 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TAPEAI-AFRK 203 Query: 190 YGVGVDMWAVGCILAELL 207 + D+W+ G ++ E++ Sbjct: 204 FTSASDVWSYGIVMWEVV 221 >3TXO-A nrPDB Length = 353 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 66/209 (31%), Positives = 96/209 (45%), Gaps = 5/209 (2%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG+G F V AR K T + A+K +K + D + T + L +H Sbjct: 25 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQ-DDDVECTMTEKRILSLARNH 83 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P + L F + V +F+ + S + + Y + L +LH Sbjct: 84 PFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDK 143 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELLFGARMY 190 I++RDLK +N+LLD G KLADFG+ K G N T T Y APE+L +Y Sbjct: 144 GIIYRDLKLDNVLLDHEGHCKLADFGMCKE-GICNGVTTATFCGTPDYIAPEIL-QEMLY 201 Query: 191 GVGVDMWAVGCILAELLL-RVPFLPGDSD 218 G VD WA+G +L E+L PF + D Sbjct: 202 GPAVDWWAMGVLLYEMLCGHAPFEAENED 230 >3ORP-A nrPDB Length = 311 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 103/217 (47%), Gaps = 12/217 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKD-GINRTALREIKLLQ 67 + RYE + LG G + V+ ARD ++ VA+K ++ A+D RE + Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRA---DLARDPSFYLRFRREAQNAA 67 Query: 68 ELSHPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKD---NSLVLTPSHIKAYMLMTLQ 123 L+HP I+ + D ++ L + ME V ++D +TP + Q Sbjct: 68 ALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQ 127 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV---TRWYRA 180 L + HQ+ I+HRD+KP N+++ +K+ DFG+A++ + T T Y + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDS 217 PE G + D++++GC+L E+L P GDS Sbjct: 188 PEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTGDS 223 >4KS7-A nrPDB Length = 292 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 107/215 (49%), Gaps = 15/215 (6%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG V AR+K++ + VA+K + L + + N E+ ++++ H N++ + Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN-----EVVIMRDYQHFNVVEM 85 Query: 78 LDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 ++ + ++ +F++ TD+ ++ L I LQ L YLH + Sbjct: 86 YKSYLVGEELWVLMEFLQGGALTDIVSQVR-----LNEEQIATVCEAVLQALAYLHAQGV 140 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 +HRD+K +++LL +G +KL+DFG V T ++ APE++ +Y Sbjct: 141 IHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATE 199 Query: 194 VDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 VD+W++G ++ E++ P DS + + R+ ++ Sbjct: 200 VDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS 234 >4CRS-A nrPDB Length = 341 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 67/208 (32%), Positives = 107/208 (51%), Gaps = 7/208 (3%) Query: 21 GQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL--REIKLLQELSHPNIIGLL 78 G F V A KNTN++ AIK +K G A+D ++ R + + + HP ++ L Sbjct: 23 GHFGKVLLAEYKNTNEMFAIKALKKGDIV-ARDEVDSLMCEKRIFETVNSVRHPFLVNLF 81 Query: 79 DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDL 138 F K ++ V ++ ++++ ++ V + Y + GL+YLH+H I++RDL Sbjct: 82 ACFQTKEHVCFVMEYAAGG-DLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDL 140 Query: 139 KPNNLLLDENGVLKLADFGLAKS-FGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMW 197 K +NLLLD G +K+ADFGL K G +R T T + APE+L Y VD W Sbjct: 141 KLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTF-CGTPEFLAPEVL-TETSYTRAVDWW 198 Query: 198 AVGCILAELLLRVPFLPGDSDLDQLTRI 225 +G ++ E+L+ PGD + + I Sbjct: 199 GLGVLIYEMLVGESPFPGDDEEEVFDSI 226 >5D7A-A nrPDB Length = 308 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 99/217 (45%), Gaps = 23/217 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E ++ +G G + VYK R T Q+ AIK + + E + +EI +L++ SH Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE------IKQEINMLKKYSH 72 Query: 72 -PNIIGLLDAF------GHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLM 120 NI AF G + LV +F TDL K N+L I Sbjct: 73 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTL--KEEWIAYICRE 130 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L+GL +LHQH ++HRD+K N+LL EN +KL DFG++ + T ++ A Sbjct: 131 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 190 Query: 181 PELLFGAR----MYGVGVDMWAVGCILAELLLRVPFL 213 PE++ Y D+W++G E+ P L Sbjct: 191 PEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL 227 >4E20-A nrPDB Length = 290 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 113/234 (48%), Gaps = 27/234 (11%) Query: 10 KRY-EKLDFLGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 KRY +K+ LGEG F V Y + T ++VA+K +K G + + G R EI+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQR----EIE 62 Query: 65 LLQELSHPNII---GLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLM 120 +L+ L H +I+ G + G KS + LV +++ L + + + L + + + Sbjct: 63 ILRTLYHEHIVKYKGCCEDQGEKS-VQLVMEYVPLGSLRDYLPRHCVGL--AQLLLFAQQ 119 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ----VVTR 176 +G+ YLH +HR L N+LLD + ++K+ DFGLAK+ + Y + Sbjct: 120 ICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 179 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 WY APE L + Y D+W+ G L ELL DS+ T+ E +G Sbjct: 180 WY-APECLKECKFY-YASDVWSFGVTLYELLTYC-----DSNQSPHTKFTELIG 226 >3IS5-A nrPDB Length = 285 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 76/287 (26%), Positives = 123/287 (42%), Gaps = 43/287 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG G F V+ ++++ IK I + I EI++L+ L HPNII + Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA----EIEVLKSLDHPNIIKI 85 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSL--VLTPSHIKAYMLMTLQGLEYLHQHWI 133 + F N+ +V + E LE I+ + L+ ++ M + L Y H + Sbjct: 86 FEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHV 145 Query: 134 LHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 +H+DLKP N+L + + +K+ DFGLA+ F S + T+ T Y APE+ R Sbjct: 146 VHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-TNAAGTALYMAPEVF--KRDV 202 Query: 191 GVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEE-QWPDMCSLPDYVT 248 D+W+ G ++ LL +PF GT EE Q P+Y Sbjct: 203 TFKCDIWSAGVVMYFLLTGCLPF----------------TGTSLEEVQQKATYKEPNYAV 246 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + P P +DL++ + +P R +A Q L ++F Sbjct: 247 -ECRPLTP----------QAVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >5LOH-A nrPDB Length = 341 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 21/205 (10%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL----SHPN 73 + G F VY + ++ A+K +K D IN+ +++ ++ P Sbjct: 44 ISRGAFGKVYLGQ--KGGKLYAVKVVK------KADMINKNMTHQVQAERDALALSKSPF 95 Query: 74 IIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 I+ L + +N+ LV +++ D++ ++ +K Y+ L+YLH+H Sbjct: 96 IVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVK-YISEVALALDYLHRHG 154 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW------YRAPELLFG 186 I+HRDLKP+N+L+ G +KL DFGL+K + + + TR Y APELL G Sbjct: 155 IIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLG 214 Query: 187 ARMYGVGVDMWAVGCILAELLLRVP 211 R +G VD WA+G L E L +P Sbjct: 215 -RAHGPAVDWWALGVCLFEFLTGIP 238 >4P5Q-A nrPDB Length = 361 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/198 (28%), Positives = 99/198 (50%), Gaps = 14/198 (7%) Query: 18 LGEGQFATVYKARDK--NTNQI-VAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 +G G+F V R K + +I VAIK +K+G+ + + R L E ++ + HPNI Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQR----RDFLGEASIMGQFDHPNI 96 Query: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 I L + +V ++ME L+ ++ + T + + G++YL Sbjct: 97 IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGY 156 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTH---QVVTRWYRAPELLFGARM 189 +HRDL N+L++ N V K++DFGL++ P AYT ++ RW +PE + R Sbjct: 157 VHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW-TSPEAI-AYRK 214 Query: 190 YGVGVDMWAVGCILAELL 207 + D+W+ G +L E++ Sbjct: 215 FTSASDVWSYGIVLWEVM 232 >4OLI-A nrPDB Length = 645 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 71/234 (30%), Positives = 112/234 (47%), Gaps = 27/234 (11%) Query: 10 KRY-EKLDFLGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 KRY +K+ LGEG F V Y + T ++VA+K +K + + G + EI Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQ----EID 407 Query: 65 LLQELSHPNII---GLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLM 120 +L+ L H +II G + G KS + LV +++ L + +S+ L + + + Sbjct: 408 ILRTLYHEHIIKYKGCCEDQGEKS-LQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFAQQ 464 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ----VVTR 176 +G+ YLH +HR+L N+LLD + ++K+ DFGLAK+ + Y + Sbjct: 465 ICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 524 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 WY APE L + Y D+W+ G L ELL DS T+ E +G Sbjct: 525 WY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG 571 >5MJB-A nrPDB Length = 305 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 98/202 (48%), Gaps = 16/202 (7%) Query: 16 DFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + +G G+F VYK R K VAIK +K G+ + + R L E ++ + H Sbjct: 32 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQR----RDFLSEASIMGQFDHR 87 Query: 73 NIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 NII L + ++ +FME L+ ++ N T + + G++YL + Sbjct: 88 NIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEM 147 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTH----QVVTRWYRAPELLF 185 +HRDL N+L++ N V K++DFGL++ + + YT ++ RW APE + Sbjct: 148 NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-TAPEAI- 205 Query: 186 GARMYGVGVDMWAVGCILAELL 207 R + D+W+ G ++ E++ Sbjct: 206 AYRKFTSASDVWSYGIVMWEVM 227 >4C0T-A nrPDB Length = 974 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 55/295 (18%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKD----GINRTALREIKLLQELSHPN 73 LGEG ++TV A DK T + A+K + H + K I + AL +L L Sbjct: 274 LGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALN--RLSNRLG--- 328 Query: 74 IIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 +I L F K ++ V D+ +L +IK + L + + L ++Y+H + Sbjct: 329 VISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN-TLNEECTRHFGAQILDAIKYMHDNG 387 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN----------RAYTHQVVTRWYRAPE 182 ++HRDLKP N+LLD+ +++ DFG A+ N RA + V T Y +PE Sbjct: 388 VIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSF-VGTAEYVSPE 446 Query: 183 LLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 LL + G D+WA GCI+ +++ + PF + Sbjct: 447 LLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATN------------------------- 480 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLL-DLIQGLFLFNPCARITATQALKMKYF 295 +Y+TF+ L FSA ++ DLI+ + + P R T + K +F Sbjct: 481 ---EYLTFQKI--TKLQFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFF 530 >4TNB-A nrPDB Length = 590 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 101/198 (51%), Gaps = 6/198 (3%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + + LG+G F V + + T ++ A K+++ R + + G AL E ++L++++ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLE-KKRIKKRKG-ESMALNEKQILEKVNS 243 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKD-NSLVLTPSHIKAYMLMTLQGLEYLH 129 ++ L A+ K + LV M DL+ I + + Y L GLE LH Sbjct: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 ++RDLKP N+LLD+ G ++++D GLA + +V T Y APE+L R Sbjct: 304 HENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLNNQR- 361 Query: 190 YGVGVDMWAVGCILAELL 207 YG+ D W +GC++ E++ Sbjct: 362 YGLSPDYWGLGCLIYEMI 379 >5X3F-B nrPDB Length = 393 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/225 (28%), Positives = 111/225 (49%), Gaps = 22/225 (9%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +++++ LG G F V + K + A+K + + K I T L E ++LQ ++ Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQ-IEHT-LNEKRILQAVN 142 Query: 71 HPNIIGLLDAFGHKSNISLVFDF-----METDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 P ++ L +F SN+ +V ++ M + L I + + H + Y + Sbjct: 143 FPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR-----FSEPHARFYAAQIVLTF 197 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 EYLH +++RDLKP NLL+D+ G +++ DFG AK R +T T Y APE++ Sbjct: 198 EYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--KGRTWT-LCGTPEYLAPEIIL 254 Query: 186 GARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETL 229 ++ Y VD WA+G ++ E+ PF DQ +I+E + Sbjct: 255 -SKGYNKAVDWWALGVLIYEMAAGYPPFFA-----DQPIQIYEKI 293 >2Y6O-A nrPDB Length = 291 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 58/214 (27%), Positives = 104/214 (48%), Gaps = 16/214 (7%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQ---IVAIKKIKLGHRSEAKDGINRT 58 A ++ + + EK+ +G G+F V R K + VAIK +K G+ + + R Sbjct: 8 AKEIDASCIKIEKV--IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQR----RD 61 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAY 117 L E ++ + HPNII L + ++ ++ME L+ ++ N T + Sbjct: 62 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGM 121 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTH---QV 173 + G++YL +HRDL N+L++ N V K++DFG+++ P AYT ++ Sbjct: 122 LRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKI 181 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 RW APE + R + D+W+ G ++ E++ Sbjct: 182 PIRW-TAPEAI-AYRKFTSASDVWSYGIVMWEVM 213 >5VD3-A nrPDB Length = 311 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 99/218 (45%), Gaps = 7/218 (3%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + +++L LG G + V+K R K ++ A+K+ R KD + A E+ +++ Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRG-PKDRARKLA--EVGSHEKV 113 Query: 70 S-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HP + L A+ + L + L+ + L + + Y+ TL L +L Sbjct: 114 GQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHL 173 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H ++H D+KP N+ L G KL DFGL G+ + R Y APELL G+ Sbjct: 174 HSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPR-YMAPELLQGS- 231 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIF 226 YG D++++G + E+ + G QL + + Sbjct: 232 -YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY 268 >3DLS-A nrPDB Length = 335 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 5/205 (2%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSE---AKDGINRTALREIKL 65 +++Y + LG G F V+ A DK N+ V +K IK E +D EI + Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL-QG 124 L + H NII +LD F ++ LV + + L++ + + +Y+ L Sbjct: 83 LSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 + YL I+HRD+K N+++ E+ +KL DFG A YT T Y APE+L Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTF-CGTIEYCAPEVL 201 Query: 185 FGARMYGVGVDMWAVGCILAELLLR 209 G G ++MW++G L L+ Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFE 226 >3VN9-A nrPDB Length = 340 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 57/229 (24%), Positives = 113/229 (49%), Gaps = 14/229 (6%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL-L 66 +A E + LG G + V K R + QI+A+K+I+ S+ + + L ++ + + Sbjct: 49 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDISM 104 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMTLQ 123 + + P + A + ++ + + M+T L+ K D + + + ++ Sbjct: 105 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 124 GLEYLHQHW-ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 LE+LH ++HRD+KP+N+L++ G +K+ DFG++ + + A T + Y APE Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPE 223 Query: 183 LL---FGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFE 227 + + Y V D+W++G + EL +LR P+ + QL ++ E Sbjct: 224 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 272 >3QD2-B nrPDB Length = 332 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 70/272 (25%), Positives = 114/272 (41%), Gaps = 85/272 (31%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + +G G F V++A++K + AIK+I+L +R A++ + +RE+K L +L H Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV----MREVKALAKLEH 63 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL------------------------ 107 P I+ +A+ + E E+ +KD S Sbjct: 64 PGIVRYFNAWLETPPEK----WQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFS 119 Query: 108 ------VLTPSHIKAYMLMTLQ----------------------------------GLEY 127 L PS K Y+ + +Q +E+ Sbjct: 120 TKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEF 179 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG---------SPNRAY---THQVVT 175 LH ++HRDLKP+N+ + V+K+ DFGL + +P AY T QV T Sbjct: 180 LHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGT 239 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + Y +PE + G Y VD++++G IL ELL Sbjct: 240 KLYMSPEQIHGNN-YSHKVDIFSLGLILFELL 270 >6DBM-A nrPDB Length = 318 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 70/234 (29%), Positives = 112/234 (47%), Gaps = 27/234 (11%) Query: 10 KRY-EKLDFLGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 KRY +K+ LGEG F V Y + T ++VA+K +K + + G + EI Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQ----EID 85 Query: 65 LLQELSHPNII---GLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLM 120 +L+ L H +II G + G +++ LV +++ L + +S+ L + + + Sbjct: 86 ILRTLYHEHIIKYKGCCEDAG-AASLQLVMEYVPLGSLRDYLPRHSIGL--AQLLLFAQQ 142 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ----VVTR 176 +G+ YLH +HRDL N+LLD + ++K+ DFGLAK+ + Y + Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 202 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 WY APE L + Y D+W+ G L ELL DS T+ E +G Sbjct: 203 WY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG 249 >4D2V-A nrPDB Length = 356 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 98/218 (44%), Gaps = 11/218 (5%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D K YE + +G G FA V A T ++VAIK + ++ + R EI Sbjct: 23 DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMD---KNTLGSDLPRIK-TEI 78 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 + L+ L H +I L + I +V ++ + II + L + + Sbjct: 79 EALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRL--SEEETRVVFRQI 136 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGL-AKSFGSPNRAYTHQVVTRWYRA 180 + + Y+H HRDLKP NLL DE LKL DFGL AK G+ + Y A Sbjct: 137 VSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAA 196 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 PEL+ G G D+W++G +L +L FLP D D Sbjct: 197 PELIQGKSYLGSEADVWSMGILL--YVLMCGFLPFDDD 232 >6ED6-A nrPDB Length = 415 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 110/231 (47%), Gaps = 15/231 (6%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTALR 61 ++ +A+ Y+ + +G G F V R K + ++ A+K K ++ RS++ Sbjct: 83 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSA-----FFWE 137 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E ++ + P ++ L AF + +V ++M V + N V K Y Sbjct: 138 ERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEV 196 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRA 180 + L+ +H ++HRD+KP+N+LLD++G LKLADFG + V T Y + Sbjct: 197 VLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYIS 256 Query: 181 PELL---FGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFE 227 PE+L G YG D W+VG L E+L+ PF DS + ++I + Sbjct: 257 PEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFY-ADSLVGTYSKIMD 306 >3UIU-A nrPDB Length = 306 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 103/227 (45%), Gaps = 42/227 (18%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +++++ +G G F V+KA+ + + I+++K N A RE+K L +L H Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYN---------NEKAEREVKALAKLDH 64 Query: 72 PNII---GLLDAFGH-----------------------KSNISLVFDFME-----TDLEV 100 NI+ G D F + +S +F ME T + Sbjct: 65 VNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQW 124 Query: 101 IIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 I K L +G++Y+H ++HRDLKP+N+ L + +K+ DFGL Sbjct: 125 IEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVT 184 Query: 161 SFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 S + + T T Y +PE + ++ YG VD++A+G ILAELL Sbjct: 185 SLKNDGKR-TRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL 229 >4U41-A nrPDB Length = 332 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 98/217 (45%), Gaps = 23/217 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E ++ +G G + VYK R T Q+ AIK + + E + + EI +L++ SH Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL------EINMLKKYSH 79 Query: 72 P-NIIGLLDAF------GHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLM 120 NI AF GH + LV +F TDL K N+L I Sbjct: 80 HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTL--KEDWIAYISRE 137 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L+GL +LH H ++HRD+K N+LL EN +KL DFG++ + T ++ A Sbjct: 138 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 197 Query: 181 PELLFGAR----MYGVGVDMWAVGCILAELLLRVPFL 213 PE++ Y D+W+ G E+ P L Sbjct: 198 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >3DKO-A nrPDB Length = 318 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 95/198 (47%), Gaps = 14/198 (7%) Query: 18 LGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 +G G+F V R K + VAIK +K+G+ + + R L E ++ + HPN+ Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQR----RDFLCEASIMGQFDHPNV 106 Query: 75 IGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 + L + +V +FME L+ ++ + T + + G+ YL Sbjct: 107 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGY 166 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTH---QVVTRWYRAPELLFGARM 189 +HRDL N+L++ N V K++DFGL++ P YT ++ RW APE + R Sbjct: 167 VHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW-TAPEAI-QYRK 224 Query: 190 YGVGVDMWAVGCILAELL 207 + D+W+ G ++ E++ Sbjct: 225 FTSASDVWSYGIVMWEVM 242 >4UYA-A nrPDB Length = 340 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 104/216 (48%), Gaps = 21/216 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +R E + +G G F VY+A + Q VA+K + +A + RE +L L Sbjct: 26 ERLELKELIGAGGFGQVYRATWQG--QEVAVKAARQDPEQDAAAAAE-SVRREARLFAML 82 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKA-YMLMTLQGLEYL 128 HPNII L + ++ LV +F + + + P H+ + + +G+ YL Sbjct: 83 RHPNIIELRGVCLQQPHLCLVLEFARGG--ALNRALAGRRIPPHVLVNWAVQIARGMLYL 140 Query: 129 HQHW---ILHRDLKPNNLLLDE--------NGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 H+ ILHRDLK +N+LL E N LK+ DFGLA+ + + T Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA-- 198 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 + APE++ + ++ G D+W+ G +L ELL VP+ Sbjct: 199 WMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPY 233 >5L6P-A nrPDB Length = 298 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 16/202 (7%) Query: 16 DFLGEGQFATVYKARDKNTNQ---IVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + +G G+F V + R K + VAIK +K+G+ + R L E ++ + HP Sbjct: 25 EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQR----RDFLSEASIMGQFDHP 80 Query: 73 NIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 NII L + ++ +FME L+ ++ N T + + G++YL + Sbjct: 81 NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM 140 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGS--PNRAYTH----QVVTRWYRAPELLF 185 +HRDL N+L++ N V K++DFGL++ + YT ++ RW APE + Sbjct: 141 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-TAPEAI- 198 Query: 186 GARMYGVGVDMWAVGCILAELL 207 R + D+W+ G ++ E++ Sbjct: 199 AYRKFTSASDVWSYGIVMWEVM 220 >3A4O-X nrPDB Length = 286 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 115/231 (49%), Gaps = 22/231 (9%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF V+ N+ + VA+K +K G S + L E L++ L H ++ L Sbjct: 21 LGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS------VQAFLEEANLMKTLQHDKLVRL 73 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNS-LVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + I ++ ++M L+ + D VL P I + +G+ Y+ + + Sbjct: 74 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLID-FSAQIAEGMAYIERKNYI 132 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELL-FGARMY 190 HRDL+ N+L+ E+ + K+ADFGLA+ + YT + ++ + APE + FG + Sbjct: 133 HRDLRAANVLVSESLMCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAINFGC--F 188 Query: 191 GVGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 + D+W+ G +L E++ ++P+ PG ++ D +T + + P E PD Sbjct: 189 TIKSDVWSFGILLYEIVTYGKIPY-PGRTNADVMTALSQGYRMPRVENCPD 238 >3RAW-A nrPDB Length = 381 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 86/333 (25%), Positives = 143/333 (42%), Gaps = 48/333 (14%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQI-VAIKKIK-LG-HRSEAKDGINRTALREIKLL 66 +RYE + LGEG F V + D + VA+K I+ +G +R A+ IN L++IK Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEIN--VLKKIKEK 108 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP-SHIKAYMLMTLQGL 125 + + + + D F ++ + F+ + + +K+N+ P H++ L Sbjct: 109 DKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 168 Query: 126 EYLHQHWILHRDLKPNNLLL-------------------DENGVLKLADFGLAKSFGSPN 166 +LH++ + H DLKP N+L +N +++ADFG A +F + Sbjct: 169 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA-TFDHEH 227 Query: 167 RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIF 226 +T V TR YR PE++ + D+W++GCIL E + + L + Sbjct: 228 --HTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMME 284 Query: 227 ETLG-------TPTEEQ---------WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 + LG T +Q W + S YV P S L D Sbjct: 285 KILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFD 344 Query: 271 LIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 L++ + F+P RIT +AL +F+ G TP Sbjct: 345 LMRRMLEFDPAQRITLAEALLHPFFA---GLTP 374 >6BXI-A nrPDB Length = 333 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 112/261 (42%), Gaps = 41/261 (15%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E L +G G F V + K+T + A+K ++ E + + A R+I L E Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDI--LVEADS 65 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 ++ + +F K N+ L+ +F+ + + LT + Y+ T+ ++ +HQ Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQL 125 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA-------------YTHQ------ 172 +HRD+KP+NLLLD G +KL+DFGL +R +T Q Sbjct: 126 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 185 Query: 173 ----------------VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 V T Y APE +F Y D W++G I+ E+L+ P + Sbjct: 186 KAETWKRNRRQLAFSTVGTPDYIAPE-VFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 244 Query: 217 SDLDQLTRIF---ETLGTPTE 234 + + ++ ETL P E Sbjct: 245 TPQETYKKVMNWKETLTFPPE 265 >6BDL-A nrPDB Length = 347 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 99/204 (48%), Gaps = 9/204 (4%) Query: 15 LDFLGEGQFATVYKARDKNT-NQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 +D LG G F V + K+ ++ A+K +K H + + + +R K + + +H + Sbjct: 39 IDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTR---QQEHIRSEKQIMQGAHSD 95 Query: 74 -IIGLLDAFGHKSNISLVFD-FMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 I+ L F + ++ + + +L I++D S + Y ++ YLH Sbjct: 96 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG-SFEDSTTRFYTACVVEAFAYLHSK 154 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 I++RDLKP NL+LD G KL DFG AK G + +T T Y APE++ + + Sbjct: 155 GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTF-CGTPEYVAPEIILN-KGHD 212 Query: 192 VGVDMWAVGCILAELLLRVPFLPG 215 + D W++G ++ ELL P G Sbjct: 213 ISADYWSLGILMYELLTGSPPFSG 236 >2W1I-A nrPDB Length = 326 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 20/208 (9%) Query: 15 LDFLGEGQFATVYKAR----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 L LG+G F +V R NT ++VA+KK++ H +E R REI++L+ L Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ--HSTEEH---LRDFEREIEILKSLQ 100 Query: 71 HPNII---GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 H NI+ G+ + G + N+ L+ +++ L ++ + + + Y +G+E Sbjct: 101 HDNIVKYKGVCYSAGRR-NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 159 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAPE 182 YL +HRDL N+L++ +K+ DFGL K Y + WY APE Sbjct: 160 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APE 218 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRV 210 L ++ + V D+W+ G +L EL + Sbjct: 219 SLTESK-FSVASDVWSFGVVLYELFTYI 245 >5TE0-A nrPDB Length = 347 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 106/219 (48%), Gaps = 28/219 (12%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNI 74 + L EG FA V+ R N + A+K++ + + + + REI+++++LS H NI Sbjct: 25 EVLAEGGFAIVFLVRTSNGMK-CALKRMFVNNEHDLQ-----VCKREIQIMRDLSGHKNI 78 Query: 75 IGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLE 126 +G +D+ G + ++ DF V + + L T + + T + + Sbjct: 79 VGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVA 138 Query: 127 YLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAKS-FGSPNRAYTHQV-------VTR 176 LHQ I+HRDLK N+LL + G L DFG A + F +P + V T Sbjct: 139 RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 177 WYRAPEL--LFGARMYGVGVDMWAVGCILAELL-LRVPF 212 YRAPE+ L+ ++ D+WA+GC+L +L +PF Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >4KIK-B nrPDB Length = 677 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 19/217 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V + ++ T + +AIK+ R E EI++++ L+H Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC----RQELSPRNRERWCLEIQIMRRLTH 76 Query: 72 PNIIGLLDAFGHKSNIS------LVFDFMET-DLEVIIK--DNSLVLTPSHIKAYMLMTL 122 PN++ D N++ L ++ + DL + +N L I + Sbjct: 77 PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 136 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENG---VLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L YLH++ I+HRDLKP N++L + + K+ D G AK + T V T Y Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLC-TSFVGTLQYL 195 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPG 215 APELL + Y V VD W+ G + E + PFLP Sbjct: 196 APELLEQQK-YTVTVDYWSFGTLAFECITGFRPFLPN 231 >3IO7-A nrPDB Length = 313 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 100/205 (48%), Gaps = 20/205 (9%) Query: 15 LDFLGEGQFATVYKAR----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 L LG+G F +V R NT ++VA+KK++ H +E R REI++L+ L Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ--HSTEEH---LRDFEREIEILKSLQ 87 Query: 71 HPNII---GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 H NI+ G+ + G + N+ L+ +++ L ++ + + + Y +G+E Sbjct: 88 HDNIVKYKGVCYSAGRR-NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGME 146 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAPE 182 YL +HRDL N+L++ +K+ DFGL K Y + WY APE Sbjct: 147 YLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APE 205 Query: 183 LLFGARMYGVGVDMWAVGCILAELL 207 L ++ + V D+W+ G +L EL Sbjct: 206 SLTESK-FSVASDVWSFGVVLYELF 229 >2VWV-A nrPDB Length = 302 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 95/202 (47%), Gaps = 16/202 (7%) Query: 16 DFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + +G G+F V + R K VAIK +K G+ + R L E ++ + HP Sbjct: 22 EVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQR----REFLSEASIMGQFEHP 77 Query: 73 NIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 NII L + + ++ +FME L+ ++ N T + + G+ YL + Sbjct: 78 NIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEM 137 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAK------SFGSPNRAYTHQVVTRWYRAPELLF 185 +HRDL N+L++ N V K++DFGL++ S + + ++ RW APE + Sbjct: 138 SYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWT-APEAI- 195 Query: 186 GARMYGVGVDMWAVGCILAELL 207 R + D W+ G ++ E++ Sbjct: 196 AFRKFTSASDAWSYGIVMWEVM 217 >1LUF-A nrPDB Length = 343 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 98/221 (44%), Gaps = 36/221 (16%) Query: 18 LGEGQFATVYKARDK-----NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 +GEG F V++AR +VA+K +K EA + RE L+ E +P Sbjct: 55 IGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK----EEASADMQADFQREAALMAEFDNP 110 Query: 73 NIIGLLDAFGHKSNISLVFDFM---------------------ETDLEVIIKDNSLVLTP 111 NI+ LL + L+F++M +DL + +S P Sbjct: 111 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPP 170 Query: 112 SHIKAYMLMTLQ---GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN-- 166 + + Q G+ YL + +HRDL N L+ EN V+K+ADFGL+++ S + Sbjct: 171 LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYY 230 Query: 167 RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 +A + + + PE +F R Y D+WA G +L E+ Sbjct: 231 KADGNDAIPIRWMPPESIFYNR-YTTESDVWAYGVVLWEIF 270 >3FME-A nrPDB Length = 290 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 112/229 (48%), Gaps = 14/229 (6%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL-L 66 +A E + LG G + V K R + QI+A+K+I+ S+ + + L ++ + + Sbjct: 5 KADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDISM 60 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMTLQ 123 + + P + A + ++ + + M+T L+ K D + + + ++ Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 124 GLEYLHQHW-ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 LE+LH ++HRD+KP+N+L++ G +K+ DFG++ + + A + Y APE Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDDVAKDIDAGCKPYMAPE 179 Query: 183 LL---FGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFE 227 + + Y V D+W++G + EL +LR P+ + QL ++ E Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE 228 >3KUL-B nrPDB Length = 325 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 94/207 (45%), Gaps = 14/207 (6%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKL 65 A R +G G V R + Q VAIK +K G+ + R L E + Sbjct: 48 ASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQR----RDFLSEASI 103 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 + + HPNII L +V ++ME L+ ++ + T + + G Sbjct: 104 MGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAG 163 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTH---QVVTRWYRA 180 + YL +HRDL N+L+D N V K++DFGL++ P+ AYT ++ RW A Sbjct: 164 MRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW-TA 222 Query: 181 PELLFGARMYGVGVDMWAVGCILAELL 207 PE + R + D+W+ G ++ E+L Sbjct: 223 PEAI-AFRTFSSASDVWSFGVVMWEVL 248 >6FEX-A nrPDB Length = 321 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 103/231 (44%), Gaps = 33/231 (14%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGH---------RSEAKD 53 +SR + EKL GEGQF V+ + +V++ ++ GH R +A Sbjct: 15 RSRLRFKEKL---GEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 71 Query: 54 GINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPS 112 L+E+K++ L PNII LL + ++ D+ME DL + + L + Sbjct: 72 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 113 H-------IKAYMLMTL-----QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 I ML+ + G+ YL +HRDL N L+ EN +K+ADFG+++ Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 191 Query: 161 SF--GSPNRAYTHQVV-TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL 208 + G R V+ RW +L G + D+WA G L E+L+ Sbjct: 192 NLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLM 240 >3CJF-A nrPDB Length = 309 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 99/212 (46%), Gaps = 28/212 (13%) Query: 18 LGEGQFATVYKAR----DKN-TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LG G F V +A DK T + VA+K +K G A +R + E+K+L + H Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEG----ATHSEHRALMSELKILIHIGHH 90 Query: 73 -NIIGLLDAFGHKSNISLVF----DFMETDLEVIIKDNSLV---------LTPSHIKAYM 118 N++ LL A +V F + K N V LT H+ Y Sbjct: 91 LNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYS 150 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKS-FGSPN--RAYTHQVVT 175 +G+E+L +HRDL N+LL E V+K+ DFGLA+ + P+ R ++ Sbjct: 151 FQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPL 210 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 +W APE +F R+Y + D+W+ G +L E+ Sbjct: 211 KWM-APETIFD-RVYTIQSDVWSFGVLLWEIF 240 >3NYO-A nrPDB Length = 576 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 60/198 (30%), Positives = 100/198 (50%), Gaps = 6/198 (3%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + + LG+G F V + + T ++ A KK++ + K AL E ++L++++ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG--EAMALNEKQILEKVNS 243 Query: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTP-SHIKAYMLMTLQGLEYLH 129 ++ L A+ K + LV M DL+ I P + Y GLE LH Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 + I++RDLKP N+LLD++G ++++D GLA + +V T Y APE++ R Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPEVVKNER- 361 Query: 190 YGVGVDMWAVGCILAELL 207 Y D WA+GC+L E++ Sbjct: 362 YTFSPDWWALGCLLYEMI 379 >4FZF-B nrPDB Length = 283 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 95/197 (48%), Gaps = 10/197 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + KL+ +G+G F V+K D T Q+VAIK I L + + I + EI +L + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQ----EITVLSQCDS 65 Query: 72 PNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + ++ S + ++ +++ + L+++ + I + L+GL+YLH Sbjct: 66 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLL---RAGPFDEFQIATMLKEILKGLDYLH 122 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 +HRD+K N+LL E G +KLA FG+A V T ++ APE++ Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVI-QQSA 181 Query: 190 YGVGVDMWAVGCILAEL 206 Y D+W++G EL Sbjct: 182 YDSKADIWSLGITAIEL 198 >3LM0-A nrPDB Length = 327 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 122/285 (42%), Gaps = 37/285 (12%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ-ELSHPNIIG 76 LG G+FA V + K+T Q A K +K R + L EI +L+ S P +I Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQ---DCRAEILHEIAVLELAKSCPRVIN 93 Query: 77 LLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + + + S I L+ ++ + + + + +++ + + + L+G+ YLHQ+ I+ Sbjct: 94 LHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIV 153 Query: 135 HRDLKPNNLLLDEN---GVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELLFGARMY 190 H DLKP N+LL G +K+ DFG+++ G + +++ T Y APE+L Sbjct: 154 HLDLKPQNILLSSIYPLGDIKIVDFGMSRKIG--HACELREIMGTPEYLAPEIL-NYDPI 210 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 DMW +G I LL G+ + + I + +EE Sbjct: 211 TTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEE--------------- 255 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 FS+ D IQ L + NP R TA L + Sbjct: 256 ---------TFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWL 291 >6CTH-A nrPDB Length = 309 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 58/195 (29%), Positives = 96/195 (49%), Gaps = 13/195 (6%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LGEG F +VY+ ++++ +A+KK+ +K GI A E+K++ L H N++ L Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVS----RASKQGIKEYA-SEVKIISRLRHKNLVKL 77 Query: 78 LDAFGHKSNISLVFDFMETDL--EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ---HW 132 + + + LV++FM I K SL+ + + L YLH+ H Sbjct: 78 IGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLA-SALLYLHEEGDHC 136 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFG-SPNRAYTHQVVTRWYRAPELLFGARMYG 191 +LHRD+K +N++LD + KL DFGLA+ + T T Y APE L + Sbjct: 137 VLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKASK 196 Query: 192 VGVDMWAVGCILAEL 206 D+++ G + E+ Sbjct: 197 ES-DVYSFGVVALEI 210 >4RA4-A nrPDB Length = 355 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 65/215 (30%), Positives = 100/215 (46%), Gaps = 12/215 (5%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F V A K T ++ AIK +K +D + E ++L L P + Sbjct: 28 LGKGSFGKVMLADRKGTEELYAIKILK--KDVVIQDDDVECTMVEKRVLALLDKPPFLTQ 85 Query: 78 LDA-FGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 L + F + V +++ DL I+ P + Y GL +LH+ I++ Sbjct: 86 LHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAV-FYAAEISIGLFFLHKRGIIY 144 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSF---GSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 RDLK +N++LD G +K+ADFG+ K G R + T Y APE++ + YG Sbjct: 145 RDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPDYIAPEII-AYQPYGK 200 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 VD WA G +L E+L P G+ + + I E Sbjct: 201 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 >4GS6-A nrPDB Length = 315 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/207 (31%), Positives = 105/207 (50%), Gaps = 22/207 (10%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K E + +G G F V KA+ + + VAIK+I+ SE++ + + E++ L + Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRAKD--VAIKQIE----SESE---RKAFIVELRQLSRV 59 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVL---TPSHIKAYMLMTLQGLE 126 +HPNI+ L A + + LV ++ E + + L T +H ++ L QG+ Sbjct: 60 NHPNIVKLYGAC--LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 127 YLHQ---HWILHRDLKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 YLH ++HRDLKP NLLL G VLK+ DFG A + T+ + + APE Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT---HMTNNKGSAAWMAPE 174 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLR 209 + G+ Y D+++ G IL E++ R Sbjct: 175 VFEGSN-YSEKCDVFSWGIILWEVITR 200 >4UY9-A nrPDB Length = 323 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/213 (31%), Positives = 103/213 (48%), Gaps = 27/213 (12%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT---ALREIKLLQELSHP 72 + +G G F VY+A VA+K R + + I++T +E KL L HP Sbjct: 15 EIIGIGGFGKVYRAF--WIGDEVAVK----AARHDPDEDISQTIENVRQEAKLFAMLKHP 68 Query: 73 NIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 NII L + N+ LV +F L ++ + P + + + +G+ YLH Sbjct: 69 NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDE 126 Query: 132 W---ILHRDLKPNNLLL---DENG-----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 I+HRDLK +N+L+ ENG +LK+ DFGLA+ + + T + A Sbjct: 127 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTK--MSAAGTYAWMA 184 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 PE++ A M+ G D+W+ G +L ELL VPF Sbjct: 185 PEVI-RASMFSKGSDVWSYGVLLWELLTGEVPF 216 >1JPA-A nrPDB Length = 312 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 96/200 (48%), Gaps = 16/200 (8%) Query: 18 LGEGQFATVYKARDKNTNQ---IVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 +G G+F V K + VAIK +K G+ + + R L E ++ + HPN+ Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQR----RDFLSEASIMGQFDHPNV 96 Query: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 I L + + ++ +FME L+ ++ N T + + G++YL Sbjct: 97 IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNY 156 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTH----QVVTRWYRAPELLFGA 187 +HRDL N+L++ N V K++DFGL++ + + YT ++ RW APE + Sbjct: 157 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-TAPEAI-QY 214 Query: 188 RMYGVGVDMWAVGCILAELL 207 R + D+W+ G ++ E++ Sbjct: 215 RKFTSASDVWSYGIVMWEVM 234 >6FER-A nrPDB Length = 309 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 115/264 (43%), Gaps = 42/264 (15%) Query: 18 LGEGQFATVY--------KARDKN------TNQ--IVAIKKIKLGHRSEAKDGINRTALR 61 LGEGQF V+ K +DK+ NQ +VA+K + R++A L+ Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML----RADANKNARNDFLK 72 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIK-------DNSLVLTPSH 113 EIK++ L PNII LL + ++ ++ME DL + +S V T S+ Sbjct: 73 EIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSY 132 Query: 114 IKAYMLMT--LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAY 169 + T G++YL +HRDL N L+ +N +K+ADFG++++ G R Sbjct: 133 TNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQ 192 Query: 170 THQVV-TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL---RVPF--LPGDSDLDQLT 223 V+ RW +L G + D+WA G L E P+ L + ++ Sbjct: 193 GRAVLPIRWMSWESILLGK--FTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTG 250 Query: 224 RIFETLGTPTEEQWPDMCSLPDYV 247 F G T P +C PD V Sbjct: 251 EFFRDQGRQTYLPQPAIC--PDSV 272 >5TUR-A nrPDB Length = 404 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 101/210 (48%), Gaps = 10/210 (4%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQE 68 +Y+ LG G F +VY + N VAIK ++ S+ + N T + E+ LL++ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 69 LSH--PNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 245 Query: 125 LEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + + H +LHRD+K N+L+D N G LKL DFG + YT TR Y PE Sbjct: 246 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 303 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPF 212 + R +G +W++G +L +++ +PF Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPF 333 >3DTC-A nrPDB Length = 271 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 102/213 (47%), Gaps = 27/213 (12%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT---ALREIKLLQELSHP 72 + +G G F VY+A VA+K R + + I++T +E KL L HP Sbjct: 13 EIIGIGGFGKVYRAF--WIGDEVAVK----AARHDPDEDISQTIENVRQEAKLFAMLKHP 66 Query: 73 NIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 NII L + N+ LV +F L ++ + P + + + +G+ YLH Sbjct: 67 NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDE 124 Query: 132 W---ILHRDLKPNNLLL---DENG-----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 I+HRDLK +N+L+ ENG +LK+ DFGLA+ + + + A Sbjct: 125 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA--WMA 182 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPF 212 PE++ A M+ G D+W+ G +L ELL VPF Sbjct: 183 PEVI-RASMFSKGSDVWSYGVLLWELLTGEVPF 214 >5VO2-A nrPDB Length = 300 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 94/204 (46%), Gaps = 17/204 (8%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L ++G G V+ R VA+KK++ + T +IK L++L HPNI Sbjct: 17 LQWVGSGAQGAVFLGRFHGEE--VAVKKVR---------DLKET---DIKHLRKLKHPNI 62 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 I ++ +F + +TPS + + + G+ YLH H I+ Sbjct: 63 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKII 122 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGV 194 HRDLK N+L+ + V+K++DFG +K + + W APE++ + V Sbjct: 123 HRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM-APEVIRNEPV-SEKV 180 Query: 195 DMWAVGCILAELLL-RVPFLPGDS 217 D+W+ G +L ELL +P+ DS Sbjct: 181 DIWSFGVVLWELLTGEIPYKDVDS 204 >5UIU-A nrPDB Length = 323 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 102/200 (51%), Gaps = 12/200 (6%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG F VYK NT VA+KK+ + + + +EIK++ + H N++ L Sbjct: 55 MGEGGFGVVYKGYVNNTT--VAVKKLA-AMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPS---HIKAYMLM-TLQGLEYLHQHWI 133 L ++ LV+ +M ++ + + L TP H++ + G+ +LH++ Sbjct: 112 LGFSSDGDDLCLVYVYMPNG-SLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQVV-TRWYRAPELLFGARMYG 191 +HRD+K N+LLDE K++DFGLA+ S T ++V T Y APE L G Sbjct: 171 IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--IT 228 Query: 192 VGVDMWAVGCILAELLLRVP 211 D+++ G +L E++ +P Sbjct: 229 PKSDIYSFGVVLLEIITGLP 248 >1VZO-A nrPDB Length = 355 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 95/204 (46%), Gaps = 7/204 (3%) Query: 10 KRYEKLDFLGEGQFATVYKARD---KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + +E L LG G + V+ R +T ++ A+K +K + T L Sbjct: 54 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 113 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 P ++ L AF ++ + L+ D++ T ++ Y+ + LE Sbjct: 114 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 173 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPELL 184 +LH+ I++RD+K N+LLD NG + L DFGL+K F RAY T Y AP+++ Sbjct: 174 HLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDF-CGTIEYMAPDIV 232 Query: 185 FGARM-YGVGVDMWAVGCILAELL 207 G + VD W++G ++ ELL Sbjct: 233 RGGDSGHDKAVDWWSLGVLMYELL 256 >4OTD-A nrPDB Length = 341 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/218 (30%), Positives = 112/218 (51%), Gaps = 9/218 (4%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS- 70 ++ L LG G F V + + + ++ AIK +K G A+D + + + E ++L ++ Sbjct: 14 FKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIV-ARDEVE-SLMCEKRILAAVTS 71 Query: 71 --HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HP ++ L F ++ V ++ ++++ +S V + Y + GL++L Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGG-DLMLHIHSDVFSEPRAIFYSACVVLGLQFL 130 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQVVTRWYRAPELLFGA 187 H+H I++RDLK +NLLLD G +K+ADFGL K G +R T T + APE+L Sbjct: 131 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTF-CGTPEFLAPEVLTDT 189 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 Y VD W +G +L E+L+ PGD + + I Sbjct: 190 S-YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSI 226 >6BSD-A nrPDB Length = 876 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/237 (27%), Positives = 103/237 (43%), Gaps = 39/237 (16%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGH---------RSEAKD 53 +SR + EKL GEGQF V+ + +V++ ++ GH R +A Sbjct: 570 RSRLRFKEKL---GEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626 Query: 54 GINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVII-----KDNSL 107 L+E+K++ L PNII LL + ++ D+ME DL + +D + Sbjct: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686 Query: 108 VLTPSHIKAYMLMTLQ-------------GLEYLHQHWILHRDLKPNNLLLDENGVLKLA 154 P +A T+ G+ YL +HRDL N L+ EN +K+A Sbjct: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746 Query: 155 DFGLAKSF--GSPNRAYTHQVV-TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL 208 DFG++++ G R V+ RW +L G + D+WA G L E+L+ Sbjct: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLM 801 >5IKW-A nrPDB Length = 310 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 109/223 (48%), Gaps = 29/223 (13%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNIIG 76 L EG F+TV+ R + A+K++ + + + REI +++ELS H NI+G Sbjct: 22 LAEGGFSTVFLVRTHGGIR-CALKRMYVNNMPDLN-----VCKREITIMKELSGHKNIVG 75 Query: 77 LLDAFGHK--SNISLVFDFMETDL--EVIIKDNSLV---LTPSHIKAYMLMTLQGLEYLH 129 LD + N+ V ME +V+ + N + T + T + + LH Sbjct: 76 YLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLH 135 Query: 130 QHW--ILHRDLKPNNLLLDENGVLKLADFGLAKS-FGSPNRAYTHQV-------VTRWYR 179 Q I+HRDLK N+LL++ G L DFG A + F +P + + V T YR Sbjct: 136 QCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYR 195 Query: 180 APEL--LFGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDL 219 APE+ L+G + D+WA+GC+L +L +PF G+S + Sbjct: 196 APEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF--GESQV 236 >4YFF-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/203 (28%), Positives = 97/203 (47%), Gaps = 10/203 (4%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + +G G F VYK R +N +IVAIK+ + D RE+ +L +L+HP +I Sbjct: 48 EIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSD--VDMFCREVSILCQLNHPCVI 103 Query: 76 GLLDA-FGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ--H 131 + A S ++V ++ L ++ + +L + +G+EYLH Sbjct: 104 QFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQ 163 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR-AYTHQVVTRWYRAPELLFGARMY 190 I+HRDL +N+LL E+G +ADFG ++ S + T Q + APE+ Y Sbjct: 164 PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRY 223 Query: 191 GVGVDMWAVGCILAELLL-RVPF 212 + D+++ L E+L +PF Sbjct: 224 TIKADVFSYALCLWEILTGEIPF 246 >2X7G-A nrPDB Length = 389 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 124/289 (42%), Gaps = 79/289 (27%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLG-HRSEAKDGINRTALREIKLLQ-- 67 RY + LG G F+TV+ D + VA+K +K H +E TAL EIKLL+ Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE-------TALDEIKLLKCV 84 Query: 68 ---ELSHPN---IIGLLDAFG----HKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKA 116 + S PN ++ L+D F + ++ +VF+ + L + IIK N L +K+ Sbjct: 85 RESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKS 144 Query: 117 YMLMTLQGLEYLHQHW-ILHRDLKPNNLLL--DENGV----------------------- 150 + LQGL+YLH I+H D+KP N+L+ D+ V Sbjct: 145 IIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAV 204 Query: 151 ----------------------LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 +K+AD G A ++ +T + TR YR+ E+L GA Sbjct: 205 STAPAADLLVNPLDPRNADKIRVKIADLGNACWV---HKHFTEDIQTRQYRSIEVLIGAG 261 Query: 189 MYGVGVDMWAVGCILAEL----LLRVPFLPGD--SDLDQLTRIFETLGT 231 Y D+W+ C+ EL L P D D D + I E LG+ Sbjct: 262 -YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGS 309 >3BGP-A nrPDB Length = 333 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 101/210 (48%), Gaps = 10/210 (4%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQE 68 +Y+ LG G F +VY + N VAIK ++ S+ + N T + E+ LL++ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 69 LSH--PNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 174 Query: 125 LEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + + H +LHRD+K N+L+D N G LKL DFG + YT TR Y PE Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEW 232 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPF 212 + R +G +W++G +L +++ +PF Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPF 262 >3QA8-A nrPDB Length = 676 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 100/217 (46%), Gaps = 19/217 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V + ++T + VAIK+ R E EI+++++L+H Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC----RQELSPKNRERWCLEIQIMKKLNH 71 Query: 72 PNIIGLLDAFGHKSNIS------LVFDFMET-DLEVIIK--DNSLVLTPSHIKAYMLMTL 122 PN++ + ++ L ++ E DL + +N L I+ + Sbjct: 72 PNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDIS 131 Query: 123 QGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L YLH++ I+HRDLKP N++L + + K+ D G AK T V T Y Sbjct: 132 SALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQ-GELCTEFVGTLQYL 190 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPG 215 APELL + Y V VD W+ G + E + PFLP Sbjct: 191 APELL-EQKKYTVTVDYWSFGTLAFECITGFRPFLPN 226 >4RC3-A nrPDB Length = 289 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 101/210 (48%), Gaps = 10/210 (4%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQE 68 +Y+ LG G F +VY + N VAIK ++ S+ + N T + E+ LL++ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 69 LSH--PNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 130 Query: 125 LEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + + H +LHRD+K N+L+D N G LKL DFG + YT TR Y PE Sbjct: 131 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEW 188 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPF 212 + R +G +W++G +L +++ +PF Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPF 218 >5AMN-A nrPDB Length = 299 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 115/247 (46%), Gaps = 35/247 (14%) Query: 18 LGEGQFATVYKA-----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LGEG+F V KA + + VA+K +K A R L E +L++++HP Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK----ENASPSELRDLLSEFNVLKQVNHP 86 Query: 73 NIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV---------LTPSHIKAYMLMTL 122 ++I L A + L+ ++ + L ++++ V LT + ++ Sbjct: 87 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRWYR 179 QG++YL + ++HRDL N+L+ E +K++DFGL++ + + ++ +W Sbjct: 147 QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM- 205 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLR----VPFLPGDSDLDQLTRIFETLGTPTEE 235 A E LF +Y D+W+ G +L E++ P +P + R+F L T Sbjct: 206 AIESLFD-HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE-------RLFNLLKTGHRM 257 Query: 236 QWPDMCS 242 + PD CS Sbjct: 258 ERPDNCS 264 >6NPU-A nrPDB Length = 298 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 106/216 (49%), Gaps = 16/216 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQELSHPNIIG 76 LG GQ+ VY+ K + VA+K +K +D + L+E +++E+ HPN++ Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLK-------EDTMEVEEFLKEAAVMKEIKHPNLVQ 86 Query: 77 LLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQ-GLEYLHQHWIL 134 LL + ++ +FM +L +++ + + + YM + +EYL + + Sbjct: 87 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 146 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 HRDL N L+ EN ++K+ADFGL++ G A+ + APE L + + Sbjct: 147 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNKFSIK 205 Query: 194 VDMWAVGCILAELLLR--VPFLPGDSDLDQLTRIFE 227 D+WA G +L E+ P+ PG DL Q+ + E Sbjct: 206 SDVWAFGVLLWEIATYGMSPY-PG-IDLSQVYELLE 239 >4XEY-B nrPDB Length = 408 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 113/230 (49%), Gaps = 19/230 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQELSHPNIIG 76 LG GQ+ VY+ K + VA+K +K +D + L+E +++E+ HPN++ Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLK-------EDTMEVEEFLKEAAVMKEIKHPNLVQ 185 Query: 77 LLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQ-GLEYLHQHWIL 134 LL + ++ +FM +L +++ + + + YM + +EYL + + Sbjct: 186 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 245 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 HRDL N L+ EN ++K+ADFGL++ G A+ + APE L + + Sbjct: 246 HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNKFSIK 304 Query: 194 VDMWAVGCILAELLLR--VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 D+WA G +L E+ P+ PG +D L++++E L + P+ C Sbjct: 305 SDVWAFGVLLWEIATYGMSPY-PG---ID-LSQVYELLEKDYRMERPEGC 349 >5U6C-A nrPDB Length = 315 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 98/210 (46%), Gaps = 22/210 (10%) Query: 17 FLGEGQFATVYKA---RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 LGEG+F +V + ++ T+ VA+K +KL + S+ + L E +++ SHPN Sbjct: 43 ILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQRE---IEEFLSEAACMKDFSHPN 99 Query: 74 IIGLLDAFGHKSNISL-----VFDFMET-DLEVIIKDNSLVLTPSHIK-----AYMLMTL 122 ++ LL S+ + + FM+ DL + + L P HI +M+ Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV---TRWYR 179 G+EYL LHRDL N +L ++ + +ADFGL+K S + ++ +W Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 219 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLR 209 L R+Y D+WA G + E+ R Sbjct: 220 IESL--ADRVYTSKSDVWAFGVTMWEIATR 247 >4F9B-A nrPDB Length = 361 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 70/248 (28%), Positives = 106/248 (42%), Gaps = 40/248 (16%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D +GEG F++VY A + Q+ +KI L H I R A L N++ Sbjct: 27 DKIGEGTFSSVYLATAQL--QVGPEEKIALKHLIPTSHPI-RIAAELQCLTVAGGQDNVM 83 Query: 76 GLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 G+ F ++ + ++E + L+++ NSL ++ YML + L+ +HQ I Sbjct: 84 GVKYCFRKNDHVVIAMPYLEHESFLDIL---NSLSF--QEVREYMLNLFKALKRIHQFGI 138 Query: 134 LHRDLKPNNLLLDEN-GVLKLADFGLAKSF-------------------GSPNR-----A 168 +HRD+KP+N L + L DFGLA+ S N+ + Sbjct: 139 VHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLS 198 Query: 169 YTHQVVTRW----YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLT 223 QV R +RAPE+L +DMW+ G I LL R PF DL L Sbjct: 199 RRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALA 258 Query: 224 RIFETLGT 231 +I G+ Sbjct: 259 QIMTIRGS 266 >5H2U-A nrPDB Length = 267 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 18/215 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL--REIKLLQELSHPNII 75 LG G F V++ K+ Q VAIK I ++D + + EI+ +++L H +I+ Sbjct: 14 LGSGYFGEVFEGLWKDRVQ-VAIKVI-------SRDNLLHQQMLQSEIQAMKKLRHKHIL 65 Query: 76 GLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 L + ++ + M LE++ + VL S + +G+ YL Sbjct: 66 ALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNY 125 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR-AYTHQVVTRWYRAPELLFGARMYGV 192 +HRDL N+L+ EN + K+ DFGLA+ ++ H + +W APE L Y Sbjct: 126 IHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKW-TAPEALSRGH-YST 183 Query: 193 GVDMWAVGCILAELLLR--VPFLPGDSDLDQLTRI 225 D+W+ G +L E+ R VP+ PG S+ + R+ Sbjct: 184 KSDVWSFGILLHEMFSRGQVPY-PGMSNHEAFLRV 217 >4XUF-A nrPDB Length = 297 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 131/288 (45%), Gaps = 52/288 (18%) Query: 13 EKLDF---LGEGQF-----ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REI 63 E L+F LG G F AT Y + VA+K +K E D R AL E+ Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-----EKADSSEREALMSEL 63 Query: 64 KLLQEL-SHPNIIGLLDAFGHKSNISLVFD-----------------FMETDLEV----- 100 K++ +L SH NI+ LL A I L+F+ F E ++E Sbjct: 64 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 101 IIKDNSL-VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA 159 + ++ L VLT + + +G+E+L +HRDL N+L+ V+K+ DFGLA Sbjct: 124 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA 183 Query: 160 KSFGSPNRAYTH---QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-LRV---PF 212 + S + ++ +W APE LF +Y + D+W+ G +L E+ L V P Sbjct: 184 RDIMSDSNYVVRGNARLPVKW-MAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPG 241 Query: 213 LPGDSDLDQLTRIFETLGTP---TEEQWPDMCSLPDYVTFK--SFPGI 255 +P D++ +L + + P TEE + M S + + K SFP + Sbjct: 242 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >6GVJ-A nrPDB Length = 429 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 114/251 (45%), Gaps = 24/251 (9%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 139 ISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 194 Query: 65 LLQELSHPN--IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L + II L D I +V + DL +K + P K+Y L Sbjct: 195 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSI-DPWERKSYWKNML 253 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT--HQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + QV T Y Sbjct: 254 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 312 Query: 181 PEL---LFGARMYG-------VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETL 229 PE + +R G D+W++GCIL + + PF ++Q++++ + Sbjct: 313 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAII 369 Query: 230 GTPTEEQWPDM 240 E ++PD+ Sbjct: 370 DPNHEIEFPDI 380 >5X02-A nrPDB Length = 347 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 131/288 (45%), Gaps = 52/288 (18%) Query: 13 EKLDF---LGEGQF-----ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REI 63 E L+F LG G F AT Y + VA+K +K E D R AL E+ Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-----EKADSSEREALMSEL 102 Query: 64 KLLQEL-SHPNIIGLLDAFGHKSNISLVFD-----------------FMETDLEV----- 100 K++ +L SH NI+ LL A I L+F+ F E ++E Sbjct: 103 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 162 Query: 101 IIKDNSL-VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA 159 + ++ L VLT + + +G+E+L +HRDL N+L+ V+K+ DFGLA Sbjct: 163 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA 222 Query: 160 KSFGSPNRAYTH---QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-LRV---PF 212 + S + ++ +W APE LF +Y + D+W+ G +L E+ L V P Sbjct: 223 RDIMSDSNYVVRGNARLPVKW-MAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPG 280 Query: 213 LPGDSDLDQLTRIFETLGTP---TEEQWPDMCSLPDYVTFK--SFPGI 255 +P D++ +L + + P TEE + M S + + K SFP + Sbjct: 281 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >2QLU-A nrPDB Length = 314 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 89/297 (29%), Positives = 130/297 (43%), Gaps = 43/297 (14%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L+ G+F V+KA + N VA+K L +D + + REI + H N+ Sbjct: 20 LEIKARGRFGCVWKA--QLMNDFVAVKIFPL------QDKQSWQSEREIFSTPGMKHENL 71 Query: 75 IGLLDAFGHKSNIS----LVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + + A SN+ L+ F + L +K N ++T + + +GL YLH Sbjct: 72 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN--IITWNELCHVAETMSRGLSYLH 129 Query: 130 QH--W---------ILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTR 176 + W I HRD K N+LL + LADFGLA F G P QV TR Sbjct: 130 EDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTR 189 Query: 177 WYRAPELLFGA----RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 Y APE+L GA R + +DM+A+G +L EL+ R D +D+ FE Sbjct: 190 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCK--AADGPVDEYMLPFE----- 242 Query: 233 TEE--QWPDMCSLPDYVTFKSF-PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 EE Q P + L + V K P I H + L I+ + + AR++A Sbjct: 243 -EEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4WUA-A nrPDB Length = 401 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 79/289 (27%), Positives = 119/289 (41%), Gaps = 79/289 (27%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL- 69 RY + LG G F+TV+ + D + VA+K +K + + TAL EI+LL+ + Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK------SAEHYTETALDEIRLLKSVR 95 Query: 70 -SHPN------IIGLLDAFG----HKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAY 117 S PN ++ LLD F + ++I +VF+ + L+ IIK N L +K Sbjct: 96 NSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKI 155 Query: 118 MLMTLQGLEYLHQHW-ILHRDLKPNNLLLDENGV-------------------------- 150 + LQGL+YLH I+H D+KP N+LL N Sbjct: 156 IQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVS 215 Query: 151 -----------------------LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 +K+AD G A ++ +T + TR YR+ E+L G+ Sbjct: 216 TAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWV---HKHFTEDIQTRQYRSLEVLIGS 272 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDS------DLDQLTRIFETLG 230 Y D+W+ C+ EL S D D + I E LG Sbjct: 273 G-YNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLG 320 >5O2B-A nrPDB Length = 285 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 17/209 (8%) Query: 7 SRAKRYEKLDF-LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 S + R+ K D LG G F TVYK D T V + +L R K R E ++ Sbjct: 12 SPSGRFLKFDIELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFK-EEAEM 68 Query: 66 LQELSHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+ L HPNI+ D++ K I LV + M + V+ P ++++ Sbjct: 69 LKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQI 128 Query: 122 LQGLEYLHQHW--ILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVV-TRW 177 L+GL++LH I+HRDLK +N+ + G +K+ D GLA + ++ V+ T Sbjct: 129 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPE 185 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAEL 206 + APE+ Y VD++A G + E+ Sbjct: 186 FMAPEMY--EEHYDESVDVYAFGMCMLEM 212 >4PDO-A nrPDB Length = 299 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 96/199 (48%), Gaps = 15/199 (7%) Query: 18 LGEGQFATVYKARDKNTNQI----VAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 +G G+F VYK K ++ VAIK +K G+ + + L E ++ + SH N Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF----LGEAGIMGQFSHHN 97 Query: 74 IIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 II L + ++ ++ME L+ +++ + + + G++YL Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN 157 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTH---QVVTRWYRAPELLFGAR 188 +HRDL N+L++ N V K++DFGL++ P YT ++ RW APE + R Sbjct: 158 YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRW-TAPEAI-SYR 215 Query: 189 MYGVGVDMWAVGCILAELL 207 + D+W+ G ++ E++ Sbjct: 216 KFTSASDVWSFGIVMWEVM 234 >4AW2-A nrPDB Length = 437 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 99/212 (46%), Gaps = 17/212 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTALREIK-LLQ 67 +E L +G G F V + KN +++ A+K K ++ R+E RE + +L Sbjct: 76 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAET------ACFREERDVLV 129 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 I L AF +N+ LV D+ + DL ++ L + Y+ + ++ Sbjct: 130 NGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAID 189 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELL- 184 +HQ +HRD+KP+N+L+D NG ++LADFG + V T Y +PE+L Sbjct: 190 SVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQ 249 Query: 185 ---FGARMYGVGVDMWAVGCILAELLL-RVPF 212 G YG D W++G + E+L PF Sbjct: 250 AMEGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >5O2C-A nrPDB Length = 380 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 99/209 (47%), Gaps = 17/209 (8%) Query: 7 SRAKRYEKLDF-LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 S + R+ K D LG G F TVYK D T V + +L R K R E ++ Sbjct: 21 SPSGRFLKFDIELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFK-EEAEM 77 Query: 66 LQELSHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+ L HPNI+ D++ K I LV + M + V+ P ++++ Sbjct: 78 LKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQI 137 Query: 122 LQGLEYLHQHW--ILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVV-TRW 177 L+GL++LH I+HRDLK +N+ + G +K+ D GLA + ++ V+ T Sbjct: 138 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPE 194 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAEL 206 + APE+ Y VD++A G + E+ Sbjct: 195 FMAPEMY--EEHYDESVDVYAFGMCMLEM 221 >2XYN-A nrPDB Length = 292 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 105/216 (48%), Gaps = 16/216 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQELSHPNIIG 76 LG GQ+ VY K + VA+K +K +D + L+E +++E+ HPN++ Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLK-------EDTMEVEEFLKEAAVMKEIKHPNLVQ 92 Query: 77 LLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQ-GLEYLHQHWIL 134 LL + +V ++M +L +++ + + + YM + +EYL + + Sbjct: 93 LLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFI 152 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 HRDL N L+ EN V+K+ADFGL++ G A+ + APE L + + Sbjct: 153 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNTFSIK 211 Query: 194 VDMWAVGCILAELLLR--VPFLPGDSDLDQLTRIFE 227 D+WA G +L E+ P+ PG DL Q+ + E Sbjct: 212 SDVWAFGVLLWEIATYGMSPY-PG-IDLSQVYDLLE 245 >4IDT-A nrPDB Length = 356 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 21/198 (10%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLG-HRSEAKDGINRTALREIKLLQELSHPNIIG 76 LG G F V++ DK T A+KK++L R+E E+ L+ P I+ Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE-----------ELMACAGLTSPRIVP 130 Query: 77 LLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 L A +++ + +E L ++K+ L Y+ L+GLEYLH ILH Sbjct: 131 LYGAVREGPWVNIFMELLEGGSLGQLVKEQG-CLPEDRALYYLGQALEGLEYLHSRRILH 189 Query: 136 RDLKPNNLLLDENGV-LKLADFGLAKSF---GSPNRAYTHQVV--TRWYRAPELLFGARM 189 D+K +N+LL +G L DFG A G T + T + APE++ G R Sbjct: 190 GDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RS 248 Query: 190 YGVGVDMWAVGCILAELL 207 VD+W+ C++ +L Sbjct: 249 CDAKVDVWSSCCMMLHML 266 >3SXS-A nrPDB Length = 268 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 16/201 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF V + K VA+K IK G SE + +E + + +LSHP ++ Sbjct: 16 LGSGQFGVVKLGKWKGQYD-VAVKMIKEGSMSEDE------FFQEAQTMMKLSHPKLVKF 68 Query: 78 LDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + I +V +++ L ++ + L PS + +G+ +L H +HR Sbjct: 69 YGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGVG 193 DL N L+D + +K++DFG+ + + Y V T++ + APE +F Y Sbjct: 129 DLAARNCLVDRDLCVKVSDFGMTRYV--LDDQYVSSVGTKFPVKWSAPE-VFHYFKYSSK 185 Query: 194 VDMWAVGCILAEL--LLRVPF 212 D+WA G ++ E+ L ++P+ Sbjct: 186 SDVWAFGILMWEVFSLGKMPY 206 >2BUJ-A nrPDB Length = 317 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 45/240 (18%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K Y + LGEG F+ V + A+K+I L H + ++ A RE + + Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI-LCHEQQDRE----EAQREADMHRLF 83 Query: 70 SHPNIIGL----LDAFGHKSNISLVFDFME-----TDLEVIIKDNSLVLTPSHIKAYMLM 120 +HPNI+ L L G K L+ F + ++E + KD LT I +L Sbjct: 84 NHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERL-KDKGNFLTEDQILWLLLG 142 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH--------- 171 +GLE +H HRDLKP N+LL + G L D GS N+A H Sbjct: 143 ICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMD------LGSMNQACIHVEGSRQALT 196 Query: 172 ------QVVTRWYRAPELLFGARMYGV---GVDMWAVGCILAELLL-----RVPFLPGDS 217 Q T YRAPE LF + + V D+W++GC+L ++ + F GDS Sbjct: 197 LQDWAAQRCTISYRAPE-LFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDS 255 >3KA0-A nrPDB Length = 320 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 123/288 (42%), Gaps = 39/288 (13%) Query: 59 ALREIKLLQELSH-PNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDN-SLVLTP 111 A RE++L S P+I+ ++D + G K + ++ +L I+D T Sbjct: 55 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 114 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRA 168 M + ++YLH I HRD+KP NLL N +LKL DFG AK S N + Sbjct: 115 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-S 173 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 T T +Y APE+L G Y DMW++G I+ LL P + L ++ +T Sbjct: 174 LTEPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-AISPGMKT 231 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 + ++P+ P++ S +++ LI+ L P R+T T+ Sbjct: 232 RIRMGQYEFPN----PEW---------------SEVSEEVKMLIRNLLKTEPTQRMTITE 272 Query: 289 ALKMKYFSNRPGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 F N P ++P+ P LKE +K + T AL Sbjct: 273 ------FMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 314 >3FXW-A nrPDB Length = 336 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 114/289 (39%), Gaps = 46/289 (15%) Query: 64 KLLQELSH-------PNIIGLLDAFGH----KSNISLVFDFMETD--LEVIIKDNSLVLT 110 K QE+ H P+I+ +LD + + K + ++ + ME I + T Sbjct: 67 KARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNR 167 M +++LH H I HRD+KP NLL +++ VLKL DFG AK + Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQN 184 Query: 168 AYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 A T +Y APE+L G Y DMW++G I+ LL P + Sbjct: 185 ALQTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFP------------PFYS 231 Query: 228 TLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287 G L Y FP +S +D LI+ L +P R+T T Sbjct: 232 NTGQAISPGMKRRIRLGQY----GFPNPE----WSEVSEDAKQLIRLLLKTDPTERLTIT 283 Query: 288 QALKMKYFSNRPGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 Q F N P +P+ P L+E + +K + T AL Sbjct: 284 Q------FMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSAL 326 >3HMP-A nrPDB Length = 342 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 69/251 (27%), Positives = 115/251 (45%), Gaps = 24/251 (9%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 106 Query: 65 LLQELSHPN--IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L + II L D I +V + DL +K + P K+Y L Sbjct: 107 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSI-DPWERKSYWKNML 165 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + + QV T Y Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 224 Query: 181 PEL---LFGARMYG-------VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETL 229 PE + +R G D+W++GCIL + + PF ++Q++++ + Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAII 281 Query: 230 GTPTEEQWPDM 240 E ++PD+ Sbjct: 282 DPNHEIEFPDI 292 >2OZA-A nrPDB Length = 356 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 123/288 (42%), Gaps = 39/288 (13%) Query: 59 ALREIKLLQELSH-PNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDN-SLVLTP 111 A RE++L S P+I+ ++D + G K + ++ +L I+D T Sbjct: 57 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 116 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRA 168 M + ++YLH I HRD+KP NLL N +LKL DFG AK S N + Sbjct: 117 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-S 175 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 T T +Y APE+L G Y DMW++G I+ LL P + L ++ +T Sbjct: 176 LTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-AISPGMKT 233 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 + ++P+ P++ S +++ LI+ L P R+T T+ Sbjct: 234 RIRMGQYEFPN----PEW---------------SEVSEEVKMLIRNLLKTEPTQRMTITE 274 Query: 289 ALKMKYFSNRPGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 F N P ++P+ P LKE +K + T AL Sbjct: 275 ------FMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 316 >4TPT-A nrPDB Length = 303 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/246 (24%), Positives = 112/246 (45%), Gaps = 36/246 (14%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG+G F K K T +++ +K++ + +T L E+K+++ L HPN++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKEL-----IRCDEETQKTFLTEVKVMRSLDHPNVL 60 Query: 76 GLLDAFGHKSNISLVFDFMETDLEVIIKD--NSLVLTPSHIKAYMLMTL-QGLEYLHQHW 132 + ++L+ +++E +KD S+ P K + G+ YLH Sbjct: 61 KFIGVLYKDKKLNLLTEYIEGG---TLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMC 117 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLA-------------------KSFGSPNRAYTHQV 173 I+HRDL +N L+ + + +ADFGL+ ++ +R + V Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 174 VTR-WYRAPELLFGARMYGVGVDMWAVGCILAELLLRV----PFLPGDSDLDQLTRIFET 228 V ++ APE+L G + Y VD+++ G +L E++ +V LP D ++F Sbjct: 178 VGNPYWMAPEMLNG-KSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 229 LGTPTE 234 PT+ Sbjct: 237 KFVPTD 242 >2FO0-A nrPDB Length = 495 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 113/230 (49%), Gaps = 19/230 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN-RTALREIKLLQELSHPNIIG 76 LG GQ+ VY+ K + VA+K +K +D + L+E +++E+ HPN++ Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLK-------EDTMEVEEFLKEAAVMKEIKHPNLVQ 277 Query: 77 LLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQ-GLEYLHQHWIL 134 LL + ++ +FM +L +++ + + + YM + +EYL + + Sbjct: 278 LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI 337 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVVTRWYRAPELLFGARMYGVG 193 HR+L N L+ EN ++K+ADFGL++ G A+ + APE L + + Sbjct: 338 HRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNKFSIK 396 Query: 194 VDMWAVGCILAELLLR--VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 D+WA G +L E+ P+ PG +D L++++E L + P+ C Sbjct: 397 SDVWAFGVLLWEIATYGMSPY-PG---ID-LSQVYELLEKDYRMERPEGC 441 >1NY3-A nrPDB Length = 400 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 123/288 (42%), Gaps = 39/288 (13%) Query: 59 ALREIKLLQELSH-PNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDN-SLVLTP 111 A RE++L S P+I+ ++D + G K + ++ +L I+D T Sbjct: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRA 168 M + ++YLH I HRD+KP NLL N +LKL DFG AK S N + Sbjct: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-S 219 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 T T +Y APE+L G Y DMW++G I+ LL P + L ++ +T Sbjct: 220 LTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-AISPGMKT 277 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 + ++P+ P++ S +++ LI+ L P R+T T+ Sbjct: 278 RIRMGQYEFPN----PEW---------------SEVSEEVKMLIRNLLKTEPTQRMTITE 318 Query: 289 ALKMKYFSNRPGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 F N P ++P+ P LKE +K + T AL Sbjct: 319 ------FMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 >5AP3-A nrPDB Length = 313 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/254 (28%), Positives = 117/254 (46%), Gaps = 26/254 (10%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 ++ VK R Y L +G G + V++ ++ QI AIK + L EA + + Sbjct: 22 SMSVKGRI--YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRN 75 Query: 62 EIKLLQELSHPN--IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYML 119 EI L +L + II L D I +V + DL +K + P K+Y Sbjct: 76 EIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKKSI-DPWERKSYWK 134 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTRW 177 L+ + +HQH I+H DLKP N L+ +G+LKL DFG+A + + QV T Sbjct: 135 NMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVN 193 Query: 178 YRAPEL---LFGARMYG-------VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIF 226 Y PE + +R G D+W++GCIL + + PF ++Q++++ Sbjct: 194 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLH 250 Query: 227 ETLGTPTEEQWPDM 240 + E ++PD+ Sbjct: 251 AIIDPNHEIEFPDI 264 >5U6B-A nrPDB Length = 307 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 97/211 (45%), Gaps = 26/211 (12%) Query: 18 LGEGQFATVYKARDKNTNQI--VAIK--KIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 LGEG+F V + + + I VA+K KI + RSE +D L E ++E HPN Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELED-----FLSEAVCMKEFDHPN 85 Query: 74 IIGLLDAFGHKSNIS------LVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTL---- 122 ++ L+ S ++ FM+ DL + + L P ++ ML+ Sbjct: 86 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADI 145 Query: 123 -QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRWY 178 G+EYL +HRDL N +L+EN + +ADFGL+K + + + ++ +W Sbjct: 146 ASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWI 205 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR 209 L R+Y D+W+ G + E+ R Sbjct: 206 AIESL--ADRVYTSKSDVWSFGVTMWEIATR 234 >3TKU-A nrPDB Length = 433 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 100/212 (47%), Gaps = 17/212 (8%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTALREIK-LLQ 67 +E + +G G F V + KNT +I A+K K ++ R+E RE + +L Sbjct: 92 FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAET------ACFREERDVLV 145 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 I L AF ++++ LV D+ + DL ++ L + Y+ + ++ Sbjct: 146 NGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAID 205 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELLF 185 +HQ +HRD+KP+N+LLD NG ++LADFG + V T Y +PE+L Sbjct: 206 SIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQ 265 Query: 186 ----GARMYGVGVDMWAVGCILAELLL-RVPF 212 G YG D W++G + E+L PF Sbjct: 266 AMEDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >6BFN-A nrPDB Length = 342 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 94/205 (45%), Gaps = 19/205 (9%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG F VY+A +NT + A+K++K E + ++ L E++ L HPNI+ Sbjct: 30 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEW-TAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 78 LDAFGHKSNISLVFDFM-----ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 LV+ F+ E L + + P + +L T + +++LHQ Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD-ILLGTARAIQFLHQDS 145 Query: 133 --ILHRDLKPNNLLLDENGVLKLADFGLAK----SFGSPNR----AYTHQVVTRWYRAPE 182 ++H D+K +N+LLDE KL DFGLA+ + SP++ A T V PE Sbjct: 146 PSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPE 205 Query: 183 LLFGARMYGVGVDMWAVGCILAELL 207 V D ++ G ++ E L Sbjct: 206 EYIKTGRLAVDTDTFSFGVVVLETL 230 >5LPZ-A nrPDB Length = 332 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/203 (32%), Positives = 104/203 (51%), Gaps = 22/203 (10%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 +G G F VYKA K+ + VAIKK L H S D R + E++ + ++ H N++ Sbjct: 24 LIGSGGFGDVYKAILKDGSA-VAIKK--LIHVSGQGD---REFMAEMETIGKIKHRNLVP 77 Query: 77 LLDAFGHKSNISLVFDFME-TDLEVIIKD---NSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 LL LV++FM+ LE ++ D + L S + + + +GL +LH + Sbjct: 78 LLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 133 ---ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-----TRWYRAPELL 184 I+HRD+K +N+LLDEN +++DFG+A+ + + TH V T Y PE Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMD---THLSVSTLAGTPGYVPPEYY 194 Query: 185 FGARMYGVGVDMWAVGCILAELL 207 R G D+++ G +L ELL Sbjct: 195 QSFRCSTKG-DVYSYGVVLLELL 216 >5HI2-A nrPDB Length = 283 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 107/222 (48%), Gaps = 28/222 (12%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F TVYK + VA+K + K+ E+ +L++ H NI+ L Sbjct: 28 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKN--------EVGVLRKTRHVNIL-L 75 Query: 78 LDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + K +++V + E + L + + + T +G++YLH I+HR Sbjct: 76 FMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHR 135 Query: 137 DLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTHQVVTRWYRAPELLFGARM----- 189 DLK NN+ L E+ +K+ DFGLA KS S + + + + APE++ RM Sbjct: 136 DLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI---RMQDSNP 192 Query: 190 YGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLG 230 Y D++A G +L EL+ ++P+ S+++ +I E +G Sbjct: 193 YSFQSDVYAFGIVLYELMTGQLPY----SNINNRDQIIEMVG 230 >5LPV-A nrPDB Length = 296 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/203 (32%), Positives = 104/203 (51%), Gaps = 22/203 (10%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 +G G F VYKA K+ + VAIKK L H S D R + E++ + ++ H N++ Sbjct: 24 LIGSGGFGDVYKAILKDGSA-VAIKK--LIHVSGQGD---REFMAEMETIGKIKHRNLVP 77 Query: 77 LLDAFGHKSNISLVFDFME-TDLEVIIKD---NSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 LL LV++FM+ LE ++ D + L S + + + +GL +LH + Sbjct: 78 LLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNC 137 Query: 133 ---ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-----TRWYRAPELL 184 I+HRD+K +N+LLDEN +++DFG+A+ + + TH V T Y PE Sbjct: 138 SPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMD---THLSVSTLAGTPGYVPPEYY 194 Query: 185 FGARMYGVGVDMWAVGCILAELL 207 R G D+++ G +L ELL Sbjct: 195 QSFRCSTKG-DVYSYGVVLLELL 216 >5TOS-A nrPDB Length = 395 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 105/226 (46%), Gaps = 33/226 (14%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKA---------RDKNTNQIVAIKKIKLGHRSEAKDG 54 ++K + + +GEG F V+K T ++A+KK+ E G Sbjct: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN----QEGFQG 114 Query: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSH 113 +R L EI L +LSHPN++ L+ + LV++FM+ LE N L ++ Sbjct: 115 -HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLE-----NHLFRRGAY 168 Query: 114 IK--------AYMLMTLQGLEYLHQH--WILHRDLKPNNLLLDENGVLKLADFGLAKS-- 161 K L +GL +LH +++RD+K +N+LLD + KL+DFGLA+ Sbjct: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 Query: 162 FGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 G + T + T Y APE + + D+++ G +L E+L Sbjct: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEIL 273 >5TQX-A nrPDB Length = 655 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 105/216 (48%), Gaps = 22/216 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V + + + +AIK +L ++ ++ EI+++++L+H Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRE----RWCHEIQIMKKLNH 65 Query: 72 PNIIGLLDAFGHKSNISLVFDF----MET----DLEVIIK--DNSLVLTPSHIKAYMLMT 121 N++ D + NI L+ D ME DL ++ +N L S I + + Sbjct: 66 ANVVKACDV-PEELNI-LIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDI 123 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENG---VLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 G+ YLH++ I+HRDLKP N++L + G + K+ D G AK T V T Y Sbjct: 124 GSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQ-GELCTEFVGTLQY 182 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRV-PFL 213 APE LF + Y VD W+ G ++ E + PFL Sbjct: 183 LAPE-LFENKPYTATVDYWSFGTMVFECIAGYRPFL 217 >1U59-A nrPDB Length = 287 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 94/198 (47%), Gaps = 16/198 (8%) Query: 18 LGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 LG G F +V Y+ R K + VAIK +K G +E D +RE +++ +L +P Sbjct: 18 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQG--TEKAD--TEEMMREAQIMHQLDNPY 71 Query: 74 IIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 I+ L+ + LV + L + + S++ + G++YL + Sbjct: 72 IVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 130 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARM 189 +HRDL N+LL K++DFGL+K+ G+ + YT + +W + APE + R Sbjct: 131 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 189 Query: 190 YGVGVDMWAVGCILAELL 207 + D+W+ G + E L Sbjct: 190 FSSRSDVWSYGVTMWEAL 207 >4HVI-A nrPDB Length = 314 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 96/202 (47%), Gaps = 20/202 (9%) Query: 18 LGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 LG+G F +V Y NT +VA+K+++ + +D REI++L+ L Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD-----FQREIQILKALHSDF 72 Query: 74 II---GLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 I+ G+ G +S + LV +++ + L ++ + L S + Y +G+EYL Sbjct: 73 IVKYRGVSYGPGRQS-LRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLG 131 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAPELLF 185 +HRDL N+L++ +K+ADFGLAK Y Q WY APE L Sbjct: 132 SRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY-APESL- 189 Query: 186 GARMYGVGVDMWAVGCILAELL 207 ++ D+W+ G +L EL Sbjct: 190 SDNIFSRQSDVWSFGVVLYELF 211 >3PFQ-A nrPDB Length = 674 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 5/203 (2%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F V + K T+++ A+K +K + D + T + + L P + L Sbjct: 349 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ-DDDVECTMVEKRVLALPGKPPFLTQL 407 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 F + V +++ DL I+ P H Y GL +L I++R Sbjct: 408 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP-HAVFYAAEIAIGLFFLQSKGIIYR 466 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDM 196 DLK +N++LD G +K+ADFG+ K T Y APE++ + YG VD Sbjct: 467 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQPYGKSVDW 525 Query: 197 WAVGCILAELLL-RVPFLPGDSD 218 WA G +L E+L + PF D D Sbjct: 526 WAFGVLLYEMLAGQAPFEGEDED 548 >2I0E-A nrPDB Length = 353 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 5/203 (2%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F V + K T+++ A+K +K + D + T + + L P + L Sbjct: 28 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQ-DDDVECTMVEKRVLALPGKPPFLTQL 86 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 F + V +++ DL I+ P H Y GL +L I++R Sbjct: 87 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP-HAVFYAAEIAIGLFFLQSKGIIYR 145 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDM 196 DLK +N++LD G +K+ADFG+ K T Y APE++ + YG VD Sbjct: 146 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AYQPYGKSVDW 204 Query: 197 WAVGCILAELLL-RVPFLPGDSD 218 WA G +L E+L + PF D D Sbjct: 205 WAFGVLLYEMLAGQAPFEGEDED 227 >4YHJ-A nrPDB Length = 584 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 56/192 (29%), Positives = 94/192 (48%), Gaps = 6/192 (3%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F V + + T ++ A KK++ + K AL E ++L+++ ++ L Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKG--EAMALNEKRILEKVQSRFVVSL 250 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKD-NSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 A+ K + LV M DL+ I + + Y GLE L + I++ Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVD 195 RDLKP N+LLD+ G ++++D GLA R +V T Y APE++ + Y D Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQRV-RGRVGTVGYMAPEVVNNEK-YTFSPD 368 Query: 196 MWAVGCILAELL 207 W +GC++ E++ Sbjct: 369 WWGLGCLIYEMI 380 >1TKI-A nrPDB Length = 321 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 64/287 (22%), Positives = 129/287 (44%), Gaps = 39/287 (13%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR-EIKLLQE 68 ++Y + LG G+F V++ + ++ + K +K+ G ++ ++ EI +L Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKV-------KGTDQVLVKKEISILNI 57 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 H NI+ L ++F + ++F+F+ D+ I ++ L I +Y+ + L++ Sbjct: 58 ARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQF 117 Query: 128 LHQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 LH H I H D++P N++ + +K+ +FG A+ P + Y APE + Sbjct: 118 LHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQL-KPGDNFRLLFTAPEYYAPE-VH 175 Query: 186 GARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + DMW++G ++ LL + PFL +++ + I T EE Sbjct: 176 QHDVVSTATDMWSLGTLVYVLLSGINPFL-AETNQQIIENIMNAEYTFDEE--------- 225 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 +F I + + +D + L + +R+TA++AL+ Sbjct: 226 ------AFKEISI---------EAMDFVDRLLVKERKSRMTASEALQ 257 >1K9A-A nrPDB Length = 450 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 99/208 (47%), Gaps = 18/208 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K + L +G+G+F V D N+ VA+K IK D + L E ++ +L Sbjct: 193 KELKLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIK-------NDATAQAFLAEASVMTQL 243 Query: 70 SHPNIIGLLDAF-GHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 H N++ LL K + +V ++M ++ + VL + + L + +E Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 YL + +HRDL N+L+ E+ V K++DFGL K S T ++ +W APE L Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPEAL-R 359 Query: 187 ARMYGVGVDMWAVGCILAEL--LLRVPF 212 + + D+W+ G +L E+ RVP+ Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPY 387 >3PLS-A nrPDB Length = 298 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 96/203 (47%), Gaps = 18/203 (8%) Query: 18 LGEGQFATVYKAR--DKNTNQI-VAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 +G+G F VY D+ N+I AIK + + + LRE L++ L+HPN+ Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAF----LREGLLMRGLNHPNV 84 Query: 75 IGLLDAFGHKSNI-SLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 + L+ + ++ +M DL I+ T + ++ L +G+EYL + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP------ELLFG 186 +HRDL N +LDE+ +K+ADFGLA+ +R Y R R P E L Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDI--LDREYYSVQQHRHARLPVKWTALESLQT 202 Query: 187 ARMYGVGVDMWAVGCILAELLLR 209 R + D+W+ G +L ELL R Sbjct: 203 YR-FTTKSDVWSFGVLLWELLTR 224 >4PWN-A nrPDB Length = 274 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/245 (26%), Positives = 110/245 (44%), Gaps = 21/245 (8%) Query: 11 RYEKLDF-LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 R+ K D +G G F TVYK D T V + +L R K R E ++L+ L Sbjct: 10 RFLKFDIEIGRGSFKTVYKGLDTETT--VEVAWCELQDRKLTKSERQRFK-EEAEMLKGL 66 Query: 70 SHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 HPNI+ D++ K I LV + M + V+ ++++ L+GL Sbjct: 67 QHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGL 126 Query: 126 EYLHQHW--ILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAP 181 ++LH I+HRDLK +N+ + G +K+ D GLA ++ V+ T + AP Sbjct: 127 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL--EKRASFAKSVIGTPEFMAP 184 Query: 182 ELLFGARMYGVGVDMWAVG-CILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 E+ Y VD++A G C+L P+ S+ +I+ + + + D Sbjct: 185 EMY--EEKYDESVDVYAFGMCMLEMATSEYPY----SECQNAAQIYRRVTSGVKPASFDK 238 Query: 241 CSLPD 245 ++P+ Sbjct: 239 VAIPE 243 >3SOC-A nrPDB Length = 322 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 71/226 (31%), Positives = 107/226 (47%), Gaps = 33/226 (14%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L+ G+F V+KA + N+ VA+K + + ++ E+ L + H NI Sbjct: 29 LEVKARGRFGCVWKA--QLLNEYVAVKIFPIQDKQSWQNEY------EVYSLPGMKHENI 80 Query: 75 ---IG-------------LLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYM 118 IG L+ AF K ++S DF++ ++ + + T + AY+ Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLS---DFLKANVVSWNELCHIAETMARGLAYL 137 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY-TH-QVVTR 176 + GL+ H+ I HRD+K N+LL N +ADFGLA F + A TH QV TR Sbjct: 138 HEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTR 197 Query: 177 WYRAPELLFGA----RMYGVGVDMWAVGCILAELLLRVPFLPGDSD 218 Y APE+L GA R + +DM+A+G +L EL R G D Sbjct: 198 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD 243 >2ZMD-A nrPDB Length = 390 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 114/251 (45%), Gaps = 24/251 (9%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 106 Query: 65 LLQELSHPN--IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L + II L D I +V + DL +K + P K+Y L Sbjct: 107 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSI-DPWERKSYWKNML 165 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + + QV Y Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMP 224 Query: 181 PEL---LFGARMYG-------VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETL 229 PE + +R G D+W++GCIL + + PF ++Q++++ + Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAII 281 Query: 230 GTPTEEQWPDM 240 E ++PD+ Sbjct: 282 DPNHEIEFPDI 292 >5GNK-A nrPDB Length = 297 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 15/208 (7%) Query: 8 RAKRYEKLDFLGEGQFATVYKA----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 + ++K+ LG G F TVYK + VAIK+++ +A N+ L E Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA----NKEILDEA 72 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + +P++ LL S + L+ M L ++++ + ++ + + Sbjct: 73 YVMASVDNPHVCRLL-GICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ---VVTRWYR 179 +G+ YL ++HRDL N+L+ +K+ DFGLAK G+ + Y + V +W Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 180 APELLFGARMYGVGVDMWAVGCILAELL 207 +L R+Y D+W+ G + EL+ Sbjct: 192 LESILH--RIYTHQSDVWSYGVTVWELM 217 >2H8H-A nrPDB Length = 535 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 106/219 (48%), Gaps = 22/219 (10%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F V+ T + VAIK +K G S L+E +++++L H ++ L Sbjct: 275 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKLRHEKLVQL 327 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 A + I +V ++M L+ + + L + G+ Y+ + +H Sbjct: 328 Y-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 386 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 RDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE R + + Sbjct: 387 RDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTI 443 Query: 193 GVDMWAVGCILAELLL--RVPFLPGDSD---LDQLTRIF 226 D+W+ G +L EL RVP+ PG + LDQ+ R + Sbjct: 444 KSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQVERGY 481 >5X5O-A nrPDB Length = 310 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 101/211 (47%), Gaps = 25/211 (11%) Query: 11 RYEKLDFL---GEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 +++ L F G G F +VY+A+ + ++ VA+KK+ +E ++L Sbjct: 13 KFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-------------LKIEKEAEILS 59 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDF--METDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 LSH NII N +V ++ + + + I + S + HI + +G+ Sbjct: 60 VLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGM 119 Query: 126 EYLHQHW---ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 YLH ++HRDLK N+++ +GVLK+ DFG ++ + + V T + APE Sbjct: 120 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHN--HTTHMSLVGTFPWMAPE 177 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLR-VPF 212 ++ + D ++ G +L E+L R VPF Sbjct: 178 VIQSLPVSET-CDTYSYGVVLWEMLTREVPF 207 >1BYG-A nrPDB Length = 278 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 99/208 (47%), Gaps = 18/208 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K + L +G+G+F V D N+ VA+K IK D + L E ++ +L Sbjct: 21 KELKLLQTIGKGEFGDVMLG-DYRGNK-VAVKCIK-------NDATAQAFLAEASVMTQL 71 Query: 70 SHPNIIGLLDAF-GHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 H N++ LL K + +V ++M ++ + VL + + L + +E Sbjct: 72 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 131 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 YL + +HRDL N+L+ E+ V K++DFGL K S T ++ +W APE L Sbjct: 132 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPEAL-R 187 Query: 187 ARMYGVGVDMWAVGCILAEL--LLRVPF 212 + + D+W+ G +L E+ RVP+ Sbjct: 188 EKKFSTKSDVWSFGILLWEIYSFGRVPY 215 >2HK5-A nrPDB Length = 270 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 110/230 (47%), Gaps = 21/230 (9%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF V+ A N + VA+K +K G S L E +++ L H ++ L Sbjct: 23 LGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMS------VEAFLAEANVMKTLQHDKLVKL 75 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 A K I ++ +FM L+ + D + + +G+ ++ Q +H Sbjct: 76 -HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 134 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELL-FGARMYG 191 RDL+ N+L+ + V K+ADFGLA+ + YT + ++ + APE + FG+ + Sbjct: 135 RDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAINFGS--FT 190 Query: 192 VGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 + D+W+ G +L E++ R+P+ PG S+ + + + P E P+ Sbjct: 191 IKSDVWSFGILLMEIVTYGRIPY-PGMSNPEVIRALERGYRMPRPENCPE 239 >2OZO-A nrPDB Length = 613 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 94/198 (47%), Gaps = 16/198 (8%) Query: 18 LGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 LG G F +V Y+ R K + VAIK +K G +E D +RE +++ +L +P Sbjct: 344 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQG--TEKAD--TEEMMREAQIMHQLDNPY 397 Query: 74 IIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 I+ L+ + LV + L + + S++ + G++YL + Sbjct: 398 IVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARM 189 +HR+L N+LL K++DFGL+K+ G+ + YT + +W + APE + R Sbjct: 457 FVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 515 Query: 190 YGVGVDMWAVGCILAELL 207 + D+W+ G + E L Sbjct: 516 FSSRSDVWSYGVTMWEAL 533 >4G3E-A nrPDB Length = 352 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 89/197 (45%), Gaps = 19/197 (9%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F V++ +DK T A+KK++L + E+ LS P I+ L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRL----------EVFRVEELVACAGLSSPRIVPL 131 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 A +++ + +E L +IK L Y+ L+GLEYLH ILH Sbjct: 132 YGAVREGPWVNIFMELLEGGSLGQLIKQMG-CLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 137 DLKPNNLLLDENGV-LKLADFGLAKSF---GSPNRAYTHQVV--TRWYRAPELLFGARMY 190 D+K +N+LL +G L DFG A G T + T + APE++ G + Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPC 249 Query: 191 GVGVDMWAVGCILAELL 207 VD+W+ C++ +L Sbjct: 250 DAKVDIWSSCCMMLHML 266 >5FM2-A nrPDB Length = 355 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 115/261 (44%), Gaps = 49/261 (18%) Query: 18 LGEGQFATVYKA-----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LGEG+F V KA + + VA+K +K A R L E +L++++HP Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK----ENASPSELRDLLSEFNVLKQVNHP 127 Query: 73 NIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLV----------------------- 108 ++I L A + L+ ++ + L ++++ V Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN-- 166 LT + ++ QG++YL + ++HRDL N+L+ E +K++DFGL++ + Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 247 Query: 167 -RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL----RVPFLPGDSDLDQ 221 + ++ +W A E LF +Y D+W+ G +L E++ P +P + Sbjct: 248 VKRSQGRIPVKWM-AIESLFD-HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE----- 300 Query: 222 LTRIFETLGTPTEEQWPDMCS 242 R+F L T + PD CS Sbjct: 301 --RLFNLLKTGHRMERPDNCS 319 >2DQ7-X nrPDB Length = 283 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 107/228 (46%), Gaps = 19/228 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF V+ N N VAIK +K G S + L E +++++L H ++ L Sbjct: 17 LGNGQFGEVWMG-TWNGNTKVAIKTLKPGTMSP------ESFLEEAQIMKKLKHDKLVQL 69 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 A + I +V ++M L+ + L ++ G+ Y+ + +H Sbjct: 70 Y-AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 128 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 RDL+ N+L+ + K+ADFGLA+ + YT + ++ + APE R + + Sbjct: 129 RDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTI 185 Query: 193 GVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 D+W+ G +L EL+ RVP+ PG ++ + L ++ P + P Sbjct: 186 KSDVWSFGILLTELVTKGRVPY-PGMNNREVLEQVERGYRMPCPQDCP 232 >3LZB-A nrPDB Length = 327 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 15/208 (7%) Query: 8 RAKRYEKLDFLGEGQFATVYKA----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 + ++K+ LG G F TVYK + VAIK+++ +A N+ L E Sbjct: 13 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA----NKEILDEA 68 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + +P++ LL S + L+ M L ++++ + ++ + + Sbjct: 69 YVMASVDNPHVCRLL-GICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 127 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ---VVTRWYR 179 +G+ YL ++HRDL N+L+ +K+ DFGLAK G+ + Y + V +W Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 187 Query: 180 APELLFGARMYGVGVDMWAVGCILAELL 207 +L R+Y D+W+ G + EL+ Sbjct: 188 LESILH--RIYTHQSDVWSYGVTVWELM 213 >3PPZ-A nrPDB Length = 309 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 92/196 (46%), Gaps = 16/196 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F TV++A ++ V I + H + LRE+ +++ L HPNI+ Sbjct: 45 IGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNE-----FLREVAIMKRLRHPNIVLF 99 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTL-QGLEYLHQHW-- 132 + A N+S+V +++ ++ K + + M + +G+ YLH Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPP 159 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG------ 186 I+HRDLK NLL+D+ +K+ DFGL++ S + T + APE+L Sbjct: 160 IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEK 219 Query: 187 ARMYGVGVDMWAVGCI 202 + +Y GV +W + + Sbjct: 220 SDVYSFGVILWELATL 235 >4X7Q-B nrPDB Length = 312 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 68/252 (26%), Positives = 109/252 (43%), Gaps = 25/252 (9%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKI---KLGHRSEAKDGINRTAL 60 D ++ Y LG+G F TV+ VAIK I ++ S D + T Sbjct: 25 DREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSV--TCP 82 Query: 61 REIKLLQELS----HPNIIGLLDAFGHKSNISLVFD--FMETDL-EVIIKDNSLVLTPSH 113 E+ LL ++ HP +I LLD F + LV + DL + I + L PS Sbjct: 83 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPS- 141 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQ 172 + + + +++ H ++HRD+K N+L+D G KL DFG + YT Sbjct: 142 -RCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH--DEPYTDF 198 Query: 173 VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET-LGT 231 TR Y PE + + + + +W++G +L +++ GD ++ I E L Sbjct: 199 DGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC------GDIPFERDQEILEAELHF 252 Query: 232 PTEEQWPDMCSL 243 P PD C+L Sbjct: 253 PAHVS-PDCCAL 263 >6E4F-A nrPDB Length = 290 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 99/205 (48%), Gaps = 24/205 (11%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF V + + VAIK IK G SE + + E K++ LSH ++ L Sbjct: 39 LGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDE------FIEEAKVMMNLSHEKLVQL 91 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL-----QGLEYLHQHW 132 + I ++ ++M + N L + L+ + + +EYL Sbjct: 92 YGVCTKQRPIFIITEYMANGCLL----NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 147 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARM 189 LHRDL N L+++ GV+K++DFGL++ + YT V +++ + PE+L ++ Sbjct: 148 FLHRDLAARNCLVNDQGVVKVSDFGLSRYV--LDDEYTSSVGSKFPVRWSPPEVLMYSK- 204 Query: 190 YGVGVDMWAVGCILAEL--LLRVPF 212 + D+WA G ++ E+ L ++P+ Sbjct: 205 FSSKSDIWAFGVLMWEIYSLGKMPY 229 >6F3F-A nrPDB Length = 455 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 106/219 (48%), Gaps = 22/219 (10%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F V+ T + VAIK +K G S L+E +++++L H ++ L Sbjct: 195 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKLRHEKLVQL 247 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 A + I +V ++M L+ + + L + G+ Y+ + +H Sbjct: 248 Y-AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVH 306 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 RDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE R + + Sbjct: 307 RDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTI 363 Query: 193 GVDMWAVGCILAELLL--RVPFLPGDSD---LDQLTRIF 226 D+W+ G +L EL RVP+ PG + LDQ+ R + Sbjct: 364 KSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQVERGY 401 >4Y93-A nrPDB Length = 446 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 99/208 (47%), Gaps = 24/208 (11%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L LG GQF V + + VAIK IK G SE + + E K++ LSH + Sbjct: 193 LKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSEDE------FIEEAKVMMNLSHEKL 245 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL-----QGLEYLH 129 + L + I ++ ++M + N L + L+ + + +EYL Sbjct: 246 VQLYGVCTKQRPIFIITEYMANGCLL----NYLREMRHRFQTQQLLEMCKDVCEAMEYLE 301 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFG 186 LHRDL N L+++ GV+K++DFG+ + + YT +++ + +PE+L Sbjct: 302 SKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYV--LDDEYTSSTGSKFPVKWASPEVLMY 359 Query: 187 ARMYGVGVDMWAVGCILAEL--LLRVPF 212 ++ + D+WA G ++ E+ L ++P+ Sbjct: 360 SK-FSSKSDIWAFGVLMWEIYSLGKMPY 386 >3LLT-A nrPDB Length = 360 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 97/215 (45%), Gaps = 31/215 (14%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G+G F V + + + A+K ++ + I L++I+ + NI+ Sbjct: 43 MGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINN-NNIVKY 101 Query: 78 LDAFGHKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 F + ++ L+F+ + L E+I ++N IK Y + L+ L YL + + H Sbjct: 102 HGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHT 161 Query: 137 DLKPNNLLLDE-------------------------NGVLKLADFGLAKSFGSPNRAYTH 171 DLKP N+LLD+ + +KL DFG A +F S Sbjct: 162 DLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA-TFKSDYHGSI- 219 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAEL 206 + TR YRAPE++ + V DMW+ GC+LAEL Sbjct: 220 -INTRQYRAPEVILNLG-WDVSSDMWSFGCVLAEL 252 >4NEU-A nrPDB Length = 333 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 48/167 (28%), Positives = 83/167 (49%), Gaps = 25/167 (14%) Query: 56 NRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHI 114 N L E K++ L H ++ LL + SLV ++ME +L ++K + + TP + Sbjct: 66 NEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLK--AEMSTPLSV 123 Query: 115 KAYMLM-TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTH 171 K +++ ++G+ YLH ++H+DLKP N+L+D + +K+AD GLA K + N + Sbjct: 124 KGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHN 183 Query: 172 QVV-----------TRWYRAPELLFGAR--------MYGVGVDMWAV 199 ++ T +Y APE L +Y V +WA+ Sbjct: 184 ELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAI 230 >4EBW-A nrPDB Length = 304 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 106/231 (45%), Gaps = 18/231 (7%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKA---RDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 D + + +R E +GEGQF V++ +N VAIK K + D + L Sbjct: 32 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK----NCTSDSVREKFL 87 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAY 117 +E +++ HP+I+ L+ ++ + ++ + E + ++ SL L + AY Sbjct: 88 QEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAY 146 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVT 175 L T L YL +HRD+ N+L+ N +KL DFGL++ +A ++ Sbjct: 147 QLST--ALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPI 204 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRI 225 +W APE + R + D+W G + E+L+ V G + D + RI Sbjct: 205 KWM-APESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 253 >2QKW-B nrPDB Length = 321 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 102/221 (46%), Gaps = 18/221 (8%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 +D++ ++ +G G F VYK ++ K+ L R+ E Sbjct: 32 VDLEEATNNFDHKFLIGHGVFGKVYKGVLRDG------AKVALKRRTPESSQGIEEFETE 85 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMT 121 I+ L HP+++ L+ ++ + L++ +ME +L+ + + L + + + Sbjct: 86 IETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEIC 145 Query: 122 L---QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV--TR 176 + +GL YLH I+HRD+K N+LLDEN V K+ DFG++K ++ + VV T Sbjct: 146 IGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTL 205 Query: 177 WYRAPELLFGARM------YGVGVDMWAVGCILAELLLRVP 211 Y PE R+ Y GV ++ V C + ++ +P Sbjct: 206 GYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLP 246 >4XI2-A nrPDB Length = 446 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 100/208 (48%), Gaps = 24/208 (11%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L LG GQF V + + VAIK I+ G SE + + E K++ LSH + Sbjct: 192 LKELGTGQFGVVKYGKWRGQYD-VAIKMIREGSMSEDE------FIEEAKVMMNLSHEKL 244 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL-----QGLEYLH 129 + L + I ++ ++M + N L + L+ + + +EYL Sbjct: 245 VQLYGVCTKQRPIFIITEYMANGCLL----NYLREMRHRFQTQQLLEMCKDVCEAMEYLE 300 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFG 186 LHRDL N L+++ GV+K++DFGL++ + YT V +++ + PE+L Sbjct: 301 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV--LDDEYTSSVGSKFPVRWSPPEVLMY 358 Query: 187 ARMYGVGVDMWAVGCILAEL--LLRVPF 212 ++ + D+WA G ++ E+ L ++P+ Sbjct: 359 SK-FSSKSDIWAFGVLMWEIYSLGKMPY 385 >5HIE-A nrPDB Length = 302 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 95/202 (47%), Gaps = 31/202 (15%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F TVYK + VA+K + K+ E+ +L++ H NI+ L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKN--------EVGVLRKTRHVNIL-L 91 Query: 78 LDAFGHKSNISLVFDFMETD-----LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 + K +++V + E L +I ++ + T QG++YLH Sbjct: 92 FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMI----KLIDIARQTAQGMDYLHAKS 147 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTHQVVTRWYRAPELLFGARM- 189 I+HRDLK NN+ L E+ +K+ DFGLA KS S + + + + APE++ RM Sbjct: 148 IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI---RMQ 204 Query: 190 ----YGVGVDMWAVGCILAELL 207 Y D++A G +L EL+ Sbjct: 205 DKNPYSFQSDVYAFGIVLYELM 226 >3OMV-A nrPDB Length = 307 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/202 (28%), Positives = 99/202 (49%), Gaps = 26/202 (12%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F TVYK + VA+K +K+ + + R E+ +L++ H NI+ L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRN---EVAVLRKTRHVNIL-L 96 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM-----TLQGLEYLHQHW 132 + K N+++V + E L + + + + L+ T QG++YLH Sbjct: 97 FMGYMTKDNLAIVTQWCEGSSLY----KHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN 152 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTHQVVTRWYRAPELLFGARM- 189 I+HRD+K NN+ L E +K+ DFGLA KS S ++ + + APE++ RM Sbjct: 153 IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVI---RMQ 209 Query: 190 ----YGVGVDMWAVGCILAELL 207 + D+++ G +L EL+ Sbjct: 210 DNNPFSFQSDVYSYGIVLYELM 231 >4AT3-A nrPDB Length = 299 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 96/211 (45%), Gaps = 28/211 (13%) Query: 18 LGEGQFATVYKARDKN-----TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LGEG F V+ A N +VA+K +K +A D + RE +LL L H Sbjct: 21 LGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-----DASDNARKDFHREAELLTNLQHE 75 Query: 73 NIIGLLDAFGHKSNISLVFDFME-TDLEVIIK----DNSLV--------LTPSHIKAYML 119 +I+ + +VF++M+ DL ++ D L+ LT S + Sbjct: 76 HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQ 135 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVV-TR 176 G+ YL +HRDL N L+ EN ++K+ DFG+++ S + R H ++ R Sbjct: 136 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 195 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELL 207 W +++ R + D+W++G +L E+ Sbjct: 196 WMPPESIMY--RKFTTESDVWSLGVVLWEIF 224 >4JLC-A nrPDB Length = 657 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 101/216 (46%), Gaps = 22/216 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + A+K D +RE ++L++L+H NI+ Sbjct: 14 DILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVD----VQMREFEVLKKLNHKNIV 69 Query: 76 GL--LDAFGHKSNISLVFDFMET-DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L ++ + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 70 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 129 Query: 131 HWILHRDLKPNNLL--LDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HRD+KP N++ + E+G V KL DFG A+ + + T Y P++ Sbjct: 130 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 188 Query: 187 A-------RMYGVGVDMWAVGCILAELLL-RVPFLP 214 A + YG VD+W+VG +PF P Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRP 224 >2PMN-X nrPDB Length = 348 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 111/252 (44%), Gaps = 32/252 (12%) Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSH-------- 113 E++++ ++ + + + + +++++ME D + + VL ++ Sbjct: 93 ELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQV 152 Query: 114 IKAYMLMTLQGLEYLH-QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ 172 IK + L Y+H + I HRD+KP+N+L+D+NG +KL+DFG ++ ++ Sbjct: 153 IKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYM--VDKKIKGS 210 Query: 173 VVTRWYRAPELLFGARMY-GVGVDMWAVG-CILAELLLRVPFLPGDSDLDQLTRIFETLG 230 T + PE Y G VD+W++G C+ VPF S L +F + Sbjct: 211 RGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKIS----LVELFNNIR 266 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLL-----DLIQGLFLFNPCARIT 285 T E D ++ PL + S ++ L D ++ NP RIT Sbjct: 267 TKNIEYPLD----------RNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERIT 316 Query: 286 ATQALKMKYFSN 297 + ALK ++ ++ Sbjct: 317 SEDALKHEWLAD 328 >3C1X-A nrPDB Length = 373 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 97/208 (46%), Gaps = 24/208 (11%) Query: 16 DFLGEGQFATVYKAR--DKNTNQI-VAIKKIK----LGHRSEAKDGINRTALREIKLLQE 68 + +G G F VY D + +I A+K + +G S+ L E ++++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQF--------LTEGIIMKD 146 Query: 69 LSHPNIIGLLD-AFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 SHPN++ LL + + +V +M+ DL I++ + T + + L +G++ Sbjct: 147 FSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK 206 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLA-----KSFGSPNRAYTHQVVTRWYRAP 181 +L +HRDL N +LDE +K+ADFGLA K F S + ++ +W Sbjct: 207 FLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALE 266 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLR 209 L + + D+W+ G +L EL+ R Sbjct: 267 SL--QTQKFTTKSDVWSFGVLLWELMTR 292 >5SYS-A nrPDB Length = 286 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 109/226 (48%), Gaps = 36/226 (15%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG+G F + T + VAIK +K G S L+E +++++L H ++ L Sbjct: 26 LGQGCFGECWMGTWNGTTR-VAIKTLKPGTMS------PEAFLQEAQVMKKLRHEKLVQL 78 Query: 78 LDAFGHK---------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 + S SL+ DF++ ++ ++ LV + I + G+ Y+ Sbjct: 79 YAVVSEEPIYIVTEYMSKGSLL-DFLKGEMGKYLRLPQLVDMAAQIAS-------GMAYV 130 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLF 185 + +HRDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE Sbjct: 131 ERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAAL 188 Query: 186 GARMYGVGVDMWAVGCILAELLL--RVPFLPGDSD---LDQLTRIF 226 R + + D+W+ G +L EL RVP+ PG + LDQ+ R + Sbjct: 189 YGR-FTIKSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQVERGY 232 >4EUU-A nrPDB Length = 319 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 101/216 (46%), Gaps = 22/216 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKLNHKNIV 70 Query: 76 GL--LDAFGHKSNISLVFDFMET-DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L ++ + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 131 HWILHRDLKPNNLL--LDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G V KL DFG A+ + + T Y P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 189 Query: 187 A-------RMYGVGVDMWAVGCILAELLL-RVPFLP 214 A + YG VD+W++G +PF P Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 225 >6O8B-A nrPDB Length = 665 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 101/216 (46%), Gaps = 22/216 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 21 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKLNHKNIV 76 Query: 76 GL--LDAFGHKSNISLVFDFMET-DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L ++ + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 77 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 136 Query: 131 HWILHRDLKPNNLL--LDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G V KL DFG A+ + + T Y P++ Sbjct: 137 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVELYGTEEYLHPDMYER 195 Query: 187 A-------RMYGVGVDMWAVGCILAELLL-RVPFLP 214 A + YG VD+W++G +PF P Sbjct: 196 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 231 >5A46-A nrPDB Length = 386 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 101/217 (46%), Gaps = 33/217 (15%) Query: 18 LGEGQFATVYKA------RDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG F V A +DK N VA+K +K S+A + + E+++++ + Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISEMEMMKMIG 103 Query: 71 -HPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDN-----SLVLTPSHIKAYMLMT-- 121 H NII LL A + ++ ++ +L ++ PSH L + Sbjct: 104 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 163 Query: 122 --------LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYT 170 +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ + + Sbjct: 164 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 223 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 ++ +W APE LF R+Y D+W+ G +L E+ Sbjct: 224 GRLPVKWM-APEALFD-RIYTHQSDVWSFGVLLWEIF 258 >1AD5-A nrPDB Length = 438 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 106/227 (46%), Gaps = 25/227 (11%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG GQF V+ A N + VA+K +K G S L E +++ L H ++ L Sbjct: 190 LGAGQFGEVWMA-TYNKHTKVAVKTMKPGSMS------VEAFLAEANVMKTLQHDKLVKL 242 Query: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 A K I ++ +FM L+ + D + + +G+ ++ Q +H Sbjct: 243 -HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 301 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL-FGARMYGVGV 194 RDL+ N+L+ + V K+ADFGLA+ + +W APE + FG+ + + Sbjct: 302 RDLRAANILVSASLVCKIADFGLARVGA--------KFPIKW-TAPEAINFGS--FTIKS 350 Query: 195 DMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 D+W+ G +L E++ R+P+ PG S+ + + + P E P+ Sbjct: 351 DVWSFGILLMEIVTYGRIPY-PGMSNPEVIRALERGYRMPRPENCPE 396 >2PSQ-A nrPDB Length = 370 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 99/217 (45%), Gaps = 33/217 (15%) Query: 18 LGEGQFATVYKA------RDKNTNQI-VAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG F V A +DK + VA+K +K +A + + E+++++ + Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK----DDATEKDLSDLVSEMEMMKMIG 144 Query: 71 -HPNIIGLLDAFGHKSNISLVFDFMETD-------------LEVIIKDNSLVLTPSHIKA 116 H NII LL A + ++ ++ +E N + K Sbjct: 145 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 204 Query: 117 YMLMTLQ---GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYT 170 + T Q G+EYL +HRDL N+L+ EN V+K+ADFGLA+ + + + Sbjct: 205 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 264 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 ++ +W APE LF R+Y D+W+ G ++ E+ Sbjct: 265 GRLPVKWM-APEALFD-RVYTHQSDVWSFGVLMWEIF 299 >5HLW-A nrPDB Length = 299 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 106/239 (44%), Gaps = 25/239 (10%) Query: 16 DFLGEGQFATVYKAR--DKNTNQI-VAIKKIK----LGHRSEAKDGINRTALREIKLLQE 68 + +G G F VY D + +I A+K + +G S+ L E ++++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQF--------LTEGIIMKD 77 Query: 69 LSHPNIIGLLD-AFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 SHPN++ LL + + +V +M+ DL I++ + T + + L +G++ Sbjct: 78 FSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK 137 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLA-----KSFGSPNRAYTHQVVTRWYRAP 181 YL +HRDL N +LDE +K+ADFGLA K + S + ++ +W Sbjct: 138 YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALE 197 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 L + + D+W+ G +L EL+ R P P + D + + E PD Sbjct: 198 SL--QTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD 254 >4EUT-A nrPDB Length = 396 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 101/216 (46%), Gaps = 22/216 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKLNHKNIV 70 Query: 76 GL--LDAFGHKSNISLVFDFMET-DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L ++ + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 131 HWILHRDLKPNNLL--LDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G V KL DFG A+ + + T Y P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 189 Query: 187 A-------RMYGVGVDMWAVGCILAELLL-RVPFLP 214 A + YG VD+W++G +PF P Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 225 >3VHK-A nrPDB Length = 368 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 5/102 (4%) Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKS-FGSPN- 166 LT H+ Y +G+E+L +HRDL N+LL E V+K+ DFGLA+ + P+ Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 167 -RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 R ++ +W APE +F R+Y + D+W+ G +L E+ Sbjct: 257 VRKGDARLPLKWM-APETIFD-RVYTIQSDVWSFGVLLWEIF 296 >6NT9-A nrPDB Length = 742 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 101/216 (46%), Gaps = 22/216 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVD----VQMREFEVLKKLNHKNIV 68 Query: 76 GL--LDAFGHKSNISLVFDFMET-DLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L ++ + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 Query: 131 HWILHRDLKPNNLL--LDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G V KL DFG A+ + + T Y P++ Sbjct: 129 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 187 Query: 187 A-------RMYGVGVDMWAVGCILAELLL-RVPFLP 214 A + YG VD+W++G +PF P Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 223 >3GQL-A nrPDB Length = 326 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 102/217 (47%), Gaps = 33/217 (15%) Query: 18 LGEGQFATVYKA------RDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG F V A +DK N VA+K +K S+A + + E+++++ + Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISEMEMMKMIG 91 Query: 71 -HPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDN-----SLVLTPSH---------- 113 H NII LL A + ++ ++ + +L ++ PSH Sbjct: 92 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 151 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYT 170 + + +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ + + Sbjct: 152 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 211 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 ++ +W APE LF R+Y D+W+ G +L E+ Sbjct: 212 GRLPVKWM-APEALFD-RIYTHQSDVWSFGVLLWEIF 246 >3TT0-A nrPDB Length = 382 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 102/217 (47%), Gaps = 33/217 (15%) Query: 18 LGEGQFATVYKA------RDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG F V A +DK N VA+K +K S+A + + E+++++ + Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISEMEMMKMIG 132 Query: 71 -HPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDN-----SLVLTPSH---------- 113 H NII LL A + ++ ++ + +L ++ PSH Sbjct: 133 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKD 192 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYT 170 + + +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ + + Sbjct: 193 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 252 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 ++ +W APE LF R+Y D+W+ G +L E+ Sbjct: 253 GRLPVKWM-APEALFD-RIYTHQSDVWSFGVLLWEIF 287 >5EG3-A nrPDB Length = 334 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 99/216 (45%), Gaps = 31/216 (14%) Query: 18 LGEGQFATVYKA------RDKNTNQI-VAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG F V A +DK + VA+K +K +A + + E+++++ + Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLK----DDATEKDLSDLVSEMEMMKMIG 98 Query: 71 -HPNIIGLLDAFGHKSNISLVFDFMETD-------------LEVIIKDNSLVLTPSHIKA 116 H NII LL A + ++ + +E+ N + K Sbjct: 99 KHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKD 158 Query: 117 YMLMTLQ---GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTH 171 + T Q G+EYL +HRDL N+L+ EN V+K+ADFGLA+ + + + T+ Sbjct: 159 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTN 218 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + + APE LF R+Y D+W+ G ++ E+ Sbjct: 219 GRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIF 253 >6CKI-A nrPDB Length = 316 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 91/323 (28%), Positives = 137/323 (42%), Gaps = 58/323 (17%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKL--GHRSEAKDGINRTALREIKLL-QELSHP 72 D LGEG A V + T+Q A+K I+ GH I RE+++L Q H Sbjct: 19 DVLGEGAHARVQTCINLITSQEYAVKIIEKQPGH-------IRSRVFREVEMLYQCQGHR 71 Query: 73 NIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLM--TLQGLEYL 128 N++ L++ F + LVF+ M + L I K + ++A +++ L++L Sbjct: 72 NVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHF----NELEASVVVQDVASALDFL 127 Query: 129 HQHWILHRDLKPNNLLLDE-NGV--LKLADFGLAKSF---GSPNRAYTHQVVTRW----Y 178 H I HRDLKP N+L + N V +K+ DFGL G + T +++T Y Sbjct: 128 HNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEY 187 Query: 179 RAPELLFG----ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 APE++ A +Y D+W++G IL LL P G G+ Sbjct: 188 MAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVG------------RCGSDCG 235 Query: 235 EQWPDMCSLPDYVTFKS-------FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287 + C + F+S FP HI AA DLI L + + R++A Sbjct: 236 WDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAK----DLISKLLVRDAKQRLSAA 291 Query: 288 QALKMKYFSNRPGPTPGCQLPRP 310 Q L+ + G P LP P Sbjct: 292 QVLQHPWVQ---GCAPENTLPTP 311 >3HNG-A nrPDB Length = 360 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 41/126 (32%), Positives = 65/126 (51%), Gaps = 7/126 (5%) Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 +T + +Y +G+E+L +HRDL N+LL EN V+K+ DFGLA+ N Sbjct: 196 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDI-YKNPD 254 Query: 169 YTHQVVTRW---YRAPELLFGARMYGVGVDMWAVGCILAEL--LLRVPFLPGDSDLDQLT 223 Y + TR + APE +F ++Y D+W+ G +L E+ L P+ D D + Sbjct: 255 YVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCS 313 Query: 224 RIFETL 229 R+ E + Sbjct: 314 RLREGM 319 >2PL0-A nrPDB Length = 289 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 107/209 (51%), Gaps = 21/209 (10%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 ++ LG GQF V+ N + VA+K +K G S + D L E L+++L H + Sbjct: 28 VERLGAGQFGEVWMGY-YNGHTKVAVKSLKQG--SMSPDAF----LAEANLMKQLQHQRL 80 Query: 75 IGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 + L A + I ++ ++ME ++ + + + LT + + +G+ ++ + Sbjct: 81 VRLY-AVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERN 139 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELL-FGAR 188 +HRDL+ N+L+ + K+ADFGLA+ + YT + ++ + APE + +G Sbjct: 140 YIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGT- 196 Query: 189 MYGVGVDMWAVGCILAELLL--RVPFLPG 215 + + D+W+ G +L E++ R+P+ PG Sbjct: 197 -FTIKSDVWSFGILLTEIVTHGRIPY-PG 223 >4LRM-A nrPDB Length = 334 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/210 (24%), Positives = 95/210 (45%), Gaps = 16/210 (7%) Query: 8 RAKRYEKLDFLGEGQFATVYKA----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 + ++K+ LG G F TVYK + VAIK+++ +A N+ L E Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA----NKEILDEA 72 Query: 64 KLLQELSHPNIIGLLDAFG--HKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLM 120 ++ + +P + G S + L+ M L ++++ + ++ + + Sbjct: 73 YVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ 132 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ---VVTRW 177 +G+ YL ++HRDL N+L+ +K+ DFGLAK G+ + Y + V +W Sbjct: 133 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 192 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELL 207 +L R+Y D+W+ G + EL+ Sbjct: 193 MALESILH--RIYTHQSDVWSYGVTVWELM 220 >4K33-A nrPDB Length = 325 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 100/212 (47%), Gaps = 23/212 (10%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA---LREIKLLQELS-HPN 73 LGEG F V A ++ A K + + + D ++ + E+++++ + H N Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 103 Query: 74 IIGLLDAFGHKSNISLVFDFM-ETDLEVIIK-------DNSL--------VLTPSHIKAY 117 II LL A + ++ ++ + +L ++ D S LT + + Sbjct: 104 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSC 163 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVT 175 +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ + + + T+ + Sbjct: 164 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRLP 223 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + APE LF R+Y D+W+ G +L E+ Sbjct: 224 VKWMAPEALFD-RVYTHQSDVWSFGVLLWEIF 254 >2J0K-A nrPDB Length = 656 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 60/231 (25%), Positives = 105/231 (45%), Gaps = 18/231 (7%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKA---RDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 D + + +R E +GEGQF V++ +N VAIK K + D + L Sbjct: 384 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK----NCTSDSVREKFL 439 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAY 117 +E +++ HP+I+ L+ ++ + ++ + E + ++ SL L + AY Sbjct: 440 QEALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAY 498 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVT 175 L T L YL +HRD+ N+L+ +KL DFGL++ +A ++ Sbjct: 499 QLST--ALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPI 556 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRI 225 +W APE + R + D+W G + E+L+ V G + D + RI Sbjct: 557 KWM-APESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI 605 >3ZZW-A nrPDB Length = 289 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 52/218 (23%), Positives = 92/218 (42%), Gaps = 32/218 (14%) Query: 15 LDFLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALR-EIKLLQE 68 ++ LGE +F VYK Q VAIK +K + +G R R E L Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK-----DKAEGPLREEFRHEAMLRAR 68 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM--------------ETDLEVIIKDNSL--VLTPS 112 L HPN++ LL +S++F + +D+ D ++ L P Sbjct: 69 LQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPP 128 Query: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--- 169 + G+EYL H ++H+DL N+L+ + +K++D GL + + + Sbjct: 129 DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLG 188 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + RW +++G + + D+W+ G +L E+ Sbjct: 189 NSLLPIRWMAPEAIMYGK--FSIDSDIWSYGVVLWEVF 224 >4M66-A nrPDB Length = 325 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 98/219 (44%), Gaps = 48/219 (21%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + +KL+F+G+G F V++A + N VA+K + ++ E+K + L Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN-----------SKKISWEVKAMVNL 68 Query: 70 SHPNIIGLLDA-----FGHKSNISLVFDFMETDLEVIIKDNSL--VLTPSHIKAYMLM-- 120 + N++ LL + S +LV FME + SL +L P + + L+ Sbjct: 69 RNENVLLLLGVTEDLQWDFVSGQALVTRFME--------NGSLAGLLQPEAPRPWPLLCR 120 Query: 121 ----TLQGLEYLHQ--HWILHRDLKPNNLLLDENGVLKLADFGLAK------SFGSPNRA 168 + G+ YLH +LHRDLKP+N+LLD KLADFGL+ S Sbjct: 121 LLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSG 180 Query: 169 YTHQVVTRWYRAPELLF--------GARMYGVGVDMWAV 199 T Y PELLF + +Y G+ +WAV Sbjct: 181 SRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAV 219 >4Y12-A nrPDB Length = 375 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 103/230 (44%), Gaps = 18/230 (7%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A +YE + G +Y A D+N N + K L H +A+ A R+ L E Sbjct: 118 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLK-GLVHSGDAEAQAMAMAERQ--FLAE 174 Query: 69 LSHPNIIGLLDAFGH--KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 + HP+I+ + + H + + + ME + + + L + AY+L L L Sbjct: 175 VVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 234 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 YLH +++ DLKP N++L E LKL D G S Y T ++APE++ Sbjct: 235 SYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLYG----TPGFQAPEIVR 289 Query: 186 GARMYGVGVDMWAVGCILAELLLRVP-----FLPGDSDLDQLTRIFETLG 230 V D++ VG LA L L +P ++ G + D + + +++ G Sbjct: 290 TGPT--VATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYG 337 >3V5Q-A nrPDB Length = 297 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 110/250 (44%), Gaps = 38/250 (15%) Query: 18 LGEGQFATVYKARDKNTN-----QIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LGEG F V+ A N + +VA+K +K + KD RE +LL L H Sbjct: 23 LGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD-----FQREAELLTNLQHE 77 Query: 73 NIIGLLDAFGHKSNISLVFDFME-TDLEVIIKD---NSLVLT---PSHIKAYMLMT---- 121 +I+ G + +VF++M+ DL ++ ++++L P K + ++ Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 122 -----LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVV 174 G+ YL +HRDL N L+ N ++K+ DFG+++ S + R H ++ Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTML 197 Query: 175 -TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL--TRIFETLGT 231 RW +++ R + D+W+ G IL E+ F G QL T + E + Sbjct: 198 PIRWMPPESIMY--RKFTTESDVWSFGVILWEI-----FTYGKQPWFQLSNTEVIECITQ 250 Query: 232 PTEEQWPDMC 241 + P +C Sbjct: 251 GRVLERPRVC 260 >6GQK-A nrPDB Length = 328 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 106/247 (42%), Gaps = 41/247 (16%) Query: 18 LGEGQFATVYKARDK-----NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-SH 71 LG G F V +A + + VA+K +K S ++ + + E+K+L L +H Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREAL----MSELKVLSYLGNH 104 Query: 72 PNIIGLLDAFGHKSNISLVFDF-------------------METDLEVIIKDNSLVLTPS 112 NI+ LL A H ++ ++ + E + KD LT Sbjct: 105 ENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKD---FLTLE 161 Query: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--- 169 H+ ++ +G+ +L +HRDL N+LL + K+ DFGLA+ + + Sbjct: 162 HLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVDKG 221 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR----VPFLPGDSDLDQLTRI 225 ++ +W APE +F + +Y D+W+ G L EL P +P DS ++ + Sbjct: 222 NARLPVKW-MAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKE 279 Query: 226 FETLGTP 232 + +P Sbjct: 280 GFRMSSP 286 >3BEA-A nrPDB Length = 333 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 96/213 (45%), Gaps = 29/213 (13%) Query: 18 LGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-H 71 LG G F V +A ++ VA+K +K ++ K+ + + E+K++ L H Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 109 Query: 72 PNIIGLLDAFGHKSNISLV---------FDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 NI+ LL A H + ++ +F+ V+ D + + S + L+ Sbjct: 110 ENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHF 169 Query: 123 -----QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH---QVV 174 QG+ +L +HRD+ N+LL V K+ DFGLA+ + + ++ Sbjct: 170 SSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLP 229 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 +W APE +F +Y V D+W+ G +L E+ Sbjct: 230 VKW-MAPESIFDC-VYTVQSDVWSYGILLWEIF 260 >3QUP-A nrPDB Length = 323 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 90/208 (43%), Gaps = 17/208 (8%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 LG+G+F +V +A+ K + +K+ LRE ++E HP++ Sbjct: 30 MLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAK 89 Query: 77 LLD------AFGHKSNISLVFDFME-TDLEVI-----IKDNSLVLTPSHIKAYMLMTLQG 124 L+ A G ++ FM+ DL I +N L + +M+ G Sbjct: 90 LVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACG 149 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRWYRAP 181 +EYL +HRDL N +L E+ + +ADFGL++ S + + ++ +W Sbjct: 150 MEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALE 209 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLR 209 L +Y V D+WA G + E++ R Sbjct: 210 SL--ADNLYTVHSDVWAFGVTMWEIMTR 235 >2PZI-A nrPDB Length = 681 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 103/230 (44%), Gaps = 18/230 (7%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A +YE + G +Y A D+N N + K L H +A+ A R+ L E Sbjct: 79 AGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLK-GLVHSGDAEAQAMAMAERQ--FLAE 135 Query: 69 LSHPNIIGLLDAFGH--KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 + HP+I+ + + H + + + ME + + + L + AY+L L L Sbjct: 136 VVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPAL 195 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 YLH +++ DLKP N++L E LKL D G S Y T ++APE++ Sbjct: 196 SYLHSIGLVYNDLKPENIMLTEEQ-LKLIDLGAVSRINSFGYLYG----TPGFQAPEIVR 250 Query: 186 GARMYGVGVDMWAVGCILAELLLRVP-----FLPGDSDLDQLTRIFETLG 230 V D++ VG LA L L +P ++ G + D + + +++ G Sbjct: 251 TGPT--VATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYG 298 >1PY5-A nrPDB Length = 326 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/245 (26%), Positives = 106/245 (43%), Gaps = 48/245 (19%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE--LSHPNII 75 +G+G+F V++ + + V I R E R+ RE ++ Q L H NI+ Sbjct: 37 IGKGRFGEVWRGKWRGEEVAVKI----FSSREE------RSWFREAEIYQTVMLRHENIL 86 Query: 76 GLLDA----FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 G + A G + + LV D+ E + N +T + L T GL +LH Sbjct: 87 GFIAADNKDNGTWTQLWLVSDYHEHG-SLFDYLNRYTVTVEGMIKLALSTASGLAHLHME 145 Query: 132 --------WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR----AYTHQVVTRWYR 179 I HRDLK N+L+ +NG +AD GLA S A H+V T+ Y Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 180 APELLFG------------ARMYGVGVDMWAVG--CILAELL--LRVPF---LPGDSDLD 220 APE+L A +Y +G+ W + C + + ++P+ +P D ++ Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE 265 Query: 221 QLTRI 225 ++ ++ Sbjct: 266 EMRKV 270 >2OGV-A nrPDB Length = 317 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 31/212 (14%) Query: 18 LGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-H 71 LG G F V +A ++ VA+K +K ++ K+ + + E+K++ L H Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 101 Query: 72 PNIIGLLDAFGHKSNISLVFDFM-------------ETDLEVIIKDNSLVLTPSHIKAYM 118 NI+ LL A H + ++ ++ E DL+ K++ L + + Sbjct: 102 ENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLD---KEDGRPLELRDLLHFS 158 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH---QVVT 175 QG+ +L +HRD+ N+LL V K+ DFGLA+ + + ++ Sbjct: 159 SQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPV 218 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 +W APE +F +Y V D+W+ G +L E+ Sbjct: 219 KW-MAPESIFDC-VYTVQSDVWSYGILLWEIF 248 >5GRN-A nrPDB Length = 356 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 43/226 (19%) Query: 18 LGEGQFA-----TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-H 71 LG G F T Y VA+K +K RS K + + E+K++ L H Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQAL----MSELKIMTHLGPH 109 Query: 72 PNIIGLLDA---------------------FGHKSNISLVFDFMETDLEVIIK-----DN 105 NI+ LL A + HK+ S + ++ L+ +K DN Sbjct: 110 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDN 169 Query: 106 SLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 S LT + ++ +G+E+L +HRDL N+LL + ++K+ DFGLA+ Sbjct: 170 SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH- 228 Query: 166 NRAYTHQVVT----RWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + Y + T +W APE +F +Y D+W+ G +L E+ Sbjct: 229 DSNYVSKGSTFLPVKW-MAPESIFD-NLYTTLSDVWSYGILLWEIF 272 >4XCU-A nrPDB Length = 300 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 94/210 (44%), Gaps = 28/210 (13%) Query: 18 LGEGQFATVYKAR-------DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG F V +A + VA+K +K A D + E+++++ + Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK----DNASDKDLADLVSEMEVMKLIG 80 Query: 71 -HPNIIGLLDAFGHKSNISLVFD---------FMETDLEVIIKDNSLVLTPSHIKAYMLM 120 H NII LL + + ++ + F+ + L AY + Sbjct: 81 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVA 140 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRW 177 +G++YL +HRDL N+L+ E+ V+K+ADFGLA+ + + ++ +W Sbjct: 141 --RGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 198 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELL 207 APE LF R+Y D+W+ G +L E+ Sbjct: 199 M-APEALFD-RVYTHQSDVWSFGILLWEIF 226 >5KMM-A nrPDB Length = 329 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 91/213 (42%), Gaps = 30/213 (14%) Query: 18 LGEGQFATVYKARDKN-----TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LGEG F V+ A N +VA+K +K EA + + RE +LL L H Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-----EASESARQDFQREAELLTMLQHQ 97 Query: 73 NIIGLLDAFGHKSNISLVFDFME------------TDLEVIIKDNSLVLTPSHIKAYMLM 120 +I+ + +VF++M D +++ + P + + + Sbjct: 98 HIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAV 157 Query: 121 TLQ---GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVV- 174 Q G+ YL +HRDL N L+ + V+K+ DFG+++ S + R ++ Sbjct: 158 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 217 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 RW +L+ R + D+W+ G +L E+ Sbjct: 218 IRWMPPESILY--RKFTTESDVWSFGVVLWEIF 248 >4LQP-A nrPDB Length = 508 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 73/151 (48%), Gaps = 2/151 (1%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + + +G+G F V + K+T +I A+K + L KD + E +L Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL-LKSEMYKKDQLAHVKA-ERDVLAGSDS 161 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P ++ L +F + L+ +F+ + + + T + YM + +E +H+ Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSF 162 +HR +KP+N+L+D G +KL+DFGL+ F Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLSTGF 252 >4OW8-A nrPDB Length = 283 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY + G V++A D + VA+K +K S+ + I R E + L+ Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-PEFIERFRA-EARTTAMLN 69 Query: 71 HPNIIGLLD-----AFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 HP I + D G LV + + + L ++K L+ H + T + Sbjct: 70 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR-LSLRHALDMLEQTGRA 128 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPEL 183 L+ H ++HRD+KP N+L+ G +K+ DFG+AK+ + T V+ T Y APE Sbjct: 129 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 188 Query: 184 LFG 186 G Sbjct: 189 ALG 191 >4FL3-A nrPDB Length = 635 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 51/193 (26%), Positives = 92/193 (47%), Gaps = 10/193 (5%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKD-GINRTALREIKLLQELSHPNIIG 76 LG G F TV K + + + L ++EA D + L E ++Q+L +P I+ Sbjct: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL--KNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 77 LLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 ++ +S + LV + E L ++ N V + I+ +++ G++YL + +H Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM-GMKYLEESNFVH 492 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 RDL N+LL K++DFGL+K+ + Y Q +W + APE + + Sbjct: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSS 551 Query: 193 GVDMWAVGCILAE 205 D+W+ G ++ E Sbjct: 552 KSDVWSFGVLMWE 564 >2HW6-A nrPDB Length = 307 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 117/299 (39%), Gaps = 45/299 (15%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIK-LLQELSHPN 73 + LGEG +A V A + A+K I E + G +R+ RE++ L Q + N Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKII------EKQAGHSRSRVFREVETLYQCQGNKN 72 Query: 74 IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 I+ L++ F + LVF+ ++ + + L++LH I Sbjct: 73 ILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGI 132 Query: 134 LHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRA-------YTHQVVTRWYRAPEL 183 HRDLKP N+L ++ +K+ DF L N T + Y APE+ Sbjct: 133 AHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEV 192 Query: 184 LF----GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 + A Y D+W++G +L +L P G D G E Sbjct: 193 VEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD--------CGWDRGE---- 240 Query: 240 MCSLPDYVTFKS-------FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 +C + F+S FP HI S A DLI L + + R++A Q L+ Sbjct: 241 VCRVCQNKLFESIQEGKYEFPDKDWAHISSEAK----DLISKLLVRDAKQRLSAAQVLQ 295 >5C26-A nrPDB Length = 299 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 51/193 (26%), Positives = 92/193 (47%), Gaps = 10/193 (5%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKD-GINRTALREIKLLQELSHPNIIG 76 LG G F TV K + + + L ++EA D + L E ++Q+L +P I+ Sbjct: 35 LGSGNFGTVKKGYYQMKKVVKTVAVKIL--KNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 77 LLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 ++ +S + LV + E L ++ N V + I+ +++ G++YL + +H Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM-GMKYLEESNFVH 150 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 RDL N+LL K++DFGL+K+ + Y Q +W + APE + + Sbjct: 151 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSS 209 Query: 193 GVDMWAVGCILAE 205 D+W+ G ++ E Sbjct: 210 KSDVWSFGVLMWE 222 >4X3F-A nrPDB Length = 337 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY + G V++A D + VA+K +K S+ + I R E + L+ Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-PEFIERFRA-EARTTAMLN 70 Query: 71 HPNIIGLLD-----AFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 HP I + D G LV + + + L ++K L+ H + T + Sbjct: 71 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR-LSLRHALDMLEQTGRA 129 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPEL 183 L+ H ++HRD+KP N+L+ G +K+ DFG+AK+ + T V+ T Y APE Sbjct: 130 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 189 Query: 184 LFG 186 G Sbjct: 190 ALG 192 >3KRL-A nrPDB Length = 335 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 31/215 (14%) Query: 18 LGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-H 71 LG G F V +A ++ VA+K +K ++ K+ + + E+K++ L H Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 109 Query: 72 PNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDN-----SLVLTPSHIKAYMLMT---- 121 NI+ LL A H + ++ ++ DL ++ PSH L + Sbjct: 110 ENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLL 169 Query: 122 ------LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH---Q 172 QG+ +L +HRD+ N+LL V K+ DFGLA+ + + + Sbjct: 170 HFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNAR 229 Query: 173 VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 + +W APE +F +Y V D+W+ G +L E+ Sbjct: 230 LPVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIF 262 >6B2Q-A nrPDB Length = 317 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY + G V++A D + VA+K +K S+ + I R E + L+ Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-PEFIERFRA-EARTTAMLN 90 Query: 71 HPNIIGLLD-----AFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 HP I + D G LV + + + L ++K L+ H + T + Sbjct: 91 HPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR-LSLRHALDMLEQTGRA 149 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPEL 183 L+ H ++HRD+KP N+L+ G +K+ DFG+AK+ + T V+ T Y APE Sbjct: 150 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 209 Query: 184 LFG 186 G Sbjct: 210 ALG 212 >2VD5-A nrPDB Length = 412 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 98/222 (44%), Gaps = 19/222 (8%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIK---KIKLGHRSEAKDGINRTAL 60 +V+ + +E L +G G F+ V + K T Q+ A+K K + R E + Sbjct: 55 EVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV------SCF 108 Query: 61 REIK-LLQELSHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVLTPSHIKAYM 118 RE + +L I L AF ++ + LV ++ + DL ++ + + Y+ Sbjct: 109 REERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYL 168 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRW 177 + ++ +H+ +HRD+KP+N+LLD G ++LADFG + + V T Sbjct: 169 AEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPD 228 Query: 178 YRAPELLFGARMYGVG------VDMWAVGCILAELLL-RVPF 212 Y +PE+L D WA+G E+ + PF Sbjct: 229 YLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 270 >2H34-A nrPDB Length = 309 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 88/210 (41%), Gaps = 12/210 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQELS 70 Y +G G VY+A D +IVA+K L + + D + RT + RE + L Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALK---LMSETLSSDPVFRTRMQREARTAGRLQ 92 Query: 71 HPNIIGLLDAFGHKSNISLVFDFM---ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 P+++ + D FG L D DL +++ L P A + L+ Sbjct: 93 EPHVVPIHD-FGEIDG-QLYVDMRLINGVDLAAMLRRQG-PLAPPRAVAIVRQIGSALDA 149 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELLFG 186 H HRD+KP N+L+ + L DFG+A + V T +Y APE F Sbjct: 150 AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE-RFS 208 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 D++A+ C+L E L P GD Sbjct: 209 ESHATYRADIYALTCVLYECLTGSPPYQGD 238 >5X1R-A nrPDB Length = 302 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 100/226 (44%), Gaps = 25/226 (11%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKK------------IKLGHRSEA---- 51 R +E + +GEG F VY+A D + +AIK+ + +G R E Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKT 78 Query: 52 -KDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVL 109 + G+N + ++E +LL SHP ++ +L + + F T L+ + + Sbjct: 79 FQAGLN-SFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKI 137 Query: 110 TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA-KSFGSPNRA 168 + I+ + + +HQ LHRD+ +N+ + E+ + L DFG A K G N + Sbjct: 138 DEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIG--NLS 195 Query: 169 YTHQVVTRWYRAPELLFGARM---YGVGVDMWAVGCILAELLLRVP 211 ++V + AP + G D++A+G +L L++ P Sbjct: 196 DETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSP 241 >2Y4I-B nrPDB Length = 319 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 72/144 (50%), Gaps = 8/144 (5%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + +G+G+F VY R VAI+ I + +E + + RE+ ++ H N++ Sbjct: 39 ELIGKGRFGQVYHGRWHGE---VAIRLIDIERDNEDQ---LKAFKREVMAYRQTRHENVV 92 Query: 76 GLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + A +++++ + L +++D +VL + + ++G+ YLH IL Sbjct: 93 LFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL 152 Query: 135 HRDLKPNNLLLDENGVLKLADFGL 158 H+DLK N+ D NG + + DFGL Sbjct: 153 HKDLKSKNVFYD-NGKVVITDFGL 175 >4R7H-A nrPDB Length = 343 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 96/222 (43%), Gaps = 38/222 (17%) Query: 18 LGEGQF-----ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-H 71 LG G F AT + ++ VA+K +K ++ K+ + + E+K++ L H Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL----MSELKIMSHLGQH 113 Query: 72 PNIIGLLDAFGHKSNISLVFDFME-----------------------TDLEVIIKDNSLV 108 NI+ LL A H + ++ ++ D E + K++ Sbjct: 114 ENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRP 173 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 L + + QG+ +L +HRD+ N+LL V K+ DFGLA+ + + Sbjct: 174 LELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNY 233 Query: 169 YTH---QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 ++ +W APE +F + +Y V D+W+ G +L E+ Sbjct: 234 IVKGNARLPVKWM-APESIFDS-VYTVQSDVWSYGILLWEIF 273 >3PP0-A nrPDB Length = 338 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 87/202 (43%), Gaps = 15/202 (7%) Query: 14 KLDFLGEGQFATVYKA----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K+ LG G F TVYK +N VAIK ++ +A N+ L E ++ + Sbjct: 21 KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA----NKEILDEAYVMAGV 76 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 P + LL S + LV M L +++N L + + + +G+ YL Sbjct: 77 GSPYVSRLL-GICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYL 135 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY---THQVVTRWYRAPELLF 185 ++HRDL N+L+ +K+ DFGLA+ Y +V +W +L Sbjct: 136 EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL- 194 Query: 186 GARMYGVGVDMWAVGCILAELL 207 R + D+W+ G + EL+ Sbjct: 195 -RRRFTHQSDVWSYGVTVWELM 215 >4F0G-A nrPDB Length = 287 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 53/161 (32%), Positives = 81/161 (50%), Gaps = 16/161 (9%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA--LREIKLLQE 68 YEK +G+G F V+K R +VAIK + LG + I + RE+ ++ Sbjct: 22 EYEKQ--IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSN 79 Query: 69 LSHPNIIGLLDAFGHKSN-ISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 L+HPNI+ L +G N +V +F+ DL + D + + S ML G+E Sbjct: 80 LNHPNIVKL---YGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 127 YLHQHW--ILHRDLKPNNLL---LDENGVL--KLADFGLAK 160 Y+ I+HRDL+ N+ LDEN + K+ADFGL++ Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ 177 >2RIO-A nrPDB Length = 434 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/179 (27%), Positives = 83/179 (46%), Gaps = 30/179 (16%) Query: 59 ALREIKLLQELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK-----DNSLVLTPS 112 AL EIKLL E HPN+I + + + + +L+ +++ D +L L Sbjct: 55 ALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKE 114 Query: 113 HIKAYMLMTL-QGLEYLHQHWILHRDLKPNNLLLD-------------ENGVLKLADFGL 158 + +L + G+ +LH I+HRDLKP N+L+ EN + ++DFGL Sbjct: 115 YNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGL 174 Query: 159 AKSFGSPNRAYTHQVV----TRWYRAPELLFGA------RMYGVGVDMWAVGCILAELL 207 K S ++ + T +RAPELL + R +D++++GC+ +L Sbjct: 175 CKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYIL 233 >3UIM-A nrPDB Length = 326 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 90/200 (45%), Gaps = 14/200 (7%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG G F VYK R + +VA+K++K E G E++++ H N++ Sbjct: 36 NILGRGGFGKVYKGRLADGT-LVAVKRLK----EERTQGGELQFQTEVEMISMAVHRNLL 90 Query: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTP---SHIKAYMLMTLQGLEYLHQH 131 L + LV+ +M + +++ P + L + +GL YLH H Sbjct: 91 RLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDH 150 Query: 132 W---ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV-TRWYRAPELLFGA 187 I+HRD+K N+LLDE + DFGLAK + T V T + APE L Sbjct: 151 CDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTG 210 Query: 188 RMYGVGVDMWAVGCILAELL 207 + D++ G +L EL+ Sbjct: 211 K-SSEKTDVFGYGVMLLELI 229 >5WNO-A nrPDB Length = 330 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 82/199 (41%), Gaps = 17/199 (8%) Query: 18 LGEGQFATV-----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LG G F TV Y R KN VAIK + + L E + L H Sbjct: 30 LGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDE------MLEEATNMFRLRHD 83 Query: 73 NIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 N++ ++ H + +V + +L+ +K + L Y G++YL + Sbjct: 84 NLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQ 143 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPELLFGAR 188 ++HRDL N+L+ + +++ DFGL+K + T +V +W +F Sbjct: 144 RVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIE--IFSKH 201 Query: 189 MYGVGVDMWAVGCILAELL 207 Y D+WA G E++ Sbjct: 202 CYTHASDVWAFGVTCWEII 220 >5XD6-A nrPDB Length = 305 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 96/213 (45%), Gaps = 28/213 (13%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y +GEG + V+ K + + AIKK+ ++ ++ L ++ ++ L Sbjct: 24 YGSKSLIGEGSYGRVFYGILK-SGKAAAIKKL------DSSKQPDQEFLAQVSMVSRLRQ 76 Query: 72 PNIIGLLD----------AFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 N++ LL A+ + N SL D + V VL+ + Sbjct: 77 ENVVALLGYCVDGPLRVLAYEYAPNGSL-HDILHGRKGVKGAQPGPVLSWHQRVKIAVGA 135 Query: 122 LQGLEYLHQH---WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA----YTHQVV 174 +GLEYLH+ ++HRD+K +N+LL ++ V K+ADF L+ +P+ A T + Sbjct: 136 ARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQ--APDMAARLHSTRVLG 193 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 T Y APE + D+++ G +L ELL Sbjct: 194 TFGYHAPEYAMTGTL-STKSDVYSFGVVLLELL 225 >1U54-B nrPDB Length = 291 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 89/203 (43%), Gaps = 17/203 (8%) Query: 15 LDFLGEGQFATVYKAR-DKNTNQIVAIK----KIKLGHRSEAKDGINRTALREIKLLQEL 69 L+ LG+G F V + D + + V++ K + + EA D +RE+ + L Sbjct: 23 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDF----IREVNAMHSL 78 Query: 70 SHPNIIGLLDAFGHKSNISLVFDF--METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 H N+I L + +V + + + L+ + K L + + Y + +G+ Y Sbjct: 79 DHRNLIRLYGVV-LTPPMKMVTELAPLGSLLDRLRKHQGHFLLGT-LSRYAVQVAEGMGY 136 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPELL 184 L +HRDL NLLL ++K+ DFGL ++ + Y H+ V + APE L Sbjct: 137 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 196 Query: 185 FGARMYGVGVDMWAVGCILAELL 207 R + D W G L E+ Sbjct: 197 -KTRTFSHASDTWMFGVTLWEMF 218 >3Q4U-A nrPDB Length = 301 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 73/314 (23%), Positives = 127/314 (40%), Gaps = 50/314 (15%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ A+ L+ +G+G++ V++ + N V I R E ++ RE +L Sbjct: 4 RTVARDITLLECVGKGRYGEVWRGSWQGENVAVKI----FSSRDE------KSWFRETEL 53 Query: 66 LQE--LSHPNIIGLLDA-------------FGHKSNISLVFDFMETDLEVIIKDNSLVLT 110 L H NI+G + + H + ++D+++ + +VL+ Sbjct: 54 YNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLS 113 Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA----KSFGSPN 166 + A++ + + G + + I HRDLK N+L+ +NG +AD GLA +S + Sbjct: 114 IASGLAHLHIEIFGTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLD 171 Query: 167 RAYTHQVVTRWYRAPELLFGARMYGV-----GVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 +V T+ Y APE+L VD+WA G +L E+ R+ Sbjct: 172 VGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS--------- 222 Query: 222 LTRIFETLGTPTEEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFL 277 I E P + P+ S D + P IP L L++ + Sbjct: 223 -NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWY 281 Query: 278 FNPCARITATQALK 291 NP AR+TA + K Sbjct: 282 QNPSARLTALRIKK 295 >4RT7-A nrPDB Length = 415 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 79/160 (49%), Gaps = 14/160 (8%) Query: 108 VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR 167 VLT + + +G+E+L +HRDL N+L+ V+K+ DFGLA+ S + Sbjct: 239 VLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSN 298 Query: 168 AYTH---QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-LRV---PFLPGDSDLD 220 ++ +W APE LF +Y + D+W+ G +L E+ L V P +P D++ Sbjct: 299 YVVRGNARLPVKW-MAPESLFEG-IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY 356 Query: 221 QLTRIFETLGTP---TEEQWPDMCSLPDYVTFK--SFPGI 255 +L + + P TEE + M S + + K SFP + Sbjct: 357 KLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 35.4 bits (80), Expect = 0.035, Method: Compositional matrix adjust. Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 15/91 (16%) Query: 13 EKLDF---LGEGQF-----ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REI 63 E L+F LG G F AT Y + VA+K +K E D R AL E+ Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-----EKADSSEREALMSEL 119 Query: 64 KLLQEL-SHPNIIGLLDAFGHKSNISLVFDF 93 K++ +L SH NI+ LL A I L+F++ Sbjct: 120 KMMTQLGSHENIVNLLGACTLSGPIYLIFEY 150 >4HZS-A nrPDB Length = 341 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 89/203 (43%), Gaps = 17/203 (8%) Query: 15 LDFLGEGQFATVYKAR-DKNTNQIVAIK----KIKLGHRSEAKDGINRTALREIKLLQEL 69 L+ LG+G F V + D + + V++ K + + EA D +RE+ + L Sbjct: 17 LEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDF----IREVNAMHSL 72 Query: 70 SHPNIIGLLDAFGHKSNISLVFDF--METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 H N+I L + +V + + + L+ + K L + + Y + +G+ Y Sbjct: 73 DHRNLIRLYGVV-LTPPMKMVTELAPLGSLLDRLRKHQGHFLLGT-LSRYAVQVAEGMGY 130 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPELL 184 L +HRDL NLLL ++K+ DFGL ++ + Y H+ V + APE L Sbjct: 131 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 190 Query: 185 FGARMYGVGVDMWAVGCILAELL 207 R + D W G L E+ Sbjct: 191 -KTRTFSHASDTWMFGVTLWEMF 212 >4JRN-A nrPDB Length = 372 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 77/314 (24%), Positives = 120/314 (38%), Gaps = 76/314 (24%) Query: 18 LGEGQFATVYKARDKNTNQIVAIK----------KIKLGHRSEAKDGINRTALREIKLLQ 67 LG G FATVY+A D TN+ +A+K + L + E+ N + + K Q Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 68 ELSH---PNIIGLLDAFGHKSNISLVFDFM--------------ETDLEVIIK----DNS 106 E P+ + +L+ G ++ +V E D+ +I D S Sbjct: 136 ESCRFMVPSDVVMLE--GQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDAS 193 Query: 107 LVLTPSHIKAYMLMTLQGLEYL---HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG 163 + + + M ++ Q ++ + I+H D+KP N LL ++G L L DFG + Sbjct: 194 VNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINN 253 Query: 164 SPNRAYTHQVVTRWYRAPELLFGAR--MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 S RA + T Y PE F A Y D W +G L + + Sbjct: 254 SVGRA----IGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCK------------ 297 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 TP + W DY+ F P P + + DLI+ L +P Sbjct: 298 ------ERPTPADGIW-------DYLHFADCPSTP---------ELVQDLIRSLLNRDPQ 335 Query: 282 ARITATQALKMKYF 295 R+ QAL+ F Sbjct: 336 KRMLPLQALETAAF 349 >4PL5-B nrPDB Length = 435 Score = 54.3 bits (129), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 89/200 (44%), Gaps = 22/200 (11%) Query: 16 DFLGEGQFAT-VYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-SHPN 73 D LG G T VYK N + VA+K+I S A RE++LL+E HPN Sbjct: 33 DVLGHGAEGTIVYKGMFDNRD--VAVKRILPECFSFAD--------REVQLLRESDEHPN 82 Query: 74 IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +I + + + L+ ++ + T GL +LH I Sbjct: 83 VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNI 142 Query: 134 LHRDLKPNNLLL---DENGVLK--LADFGLAKSFGSPNRAYTHQV---VTRWYRAPELLF 185 +HRDLKP+N+LL + +G +K ++DFGL K +++ + T + APE+L Sbjct: 143 VHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 202 Query: 186 GARMYG--VGVDMWAVGCIL 203 VD+++ GC+ Sbjct: 203 EDCKDNPTYTVDIFSAGCVF 222 >3I81-A nrPDB Length = 315 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 90/203 (44%), Gaps = 16/203 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA-LREIKLLQELSHPNIIG 76 LG+G F VY+ K + ++ + +EA R L E +++E + +++ Sbjct: 26 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVR 85 Query: 77 LLDAFGHKSNISLVFDFM-ETDLEVIIK------DNSLVLTPSHIKAYMLMTLQ---GLE 126 LL ++ + M DL+ ++ +N+ VL P + + M + G+ Sbjct: 86 LLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMA 145 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRWYRAPEL 183 YL+ + +HRDL N ++ E+ +K+ DFG+ + + + + RW L Sbjct: 146 YLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESL 205 Query: 184 LFGARMYGVGVDMWAVGCILAEL 206 G ++ D+W+ G +L E+ Sbjct: 206 KDG--VFTTYSDVWSFGVVLWEI 226 >6HV0-A nrPDB Length = 416 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 88/199 (44%), Gaps = 20/199 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-SHPNI 74 D LG G T+ R N+ VA+K+I S A RE++LL+E HPN+ Sbjct: 14 DVLGHGAEGTIV-YRGMFDNRDVAVKRILPECFSFAD--------REVQLLRESDEHPNV 64 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 I + + + L+ ++ + T GL +LH I+ Sbjct: 65 IRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIV 124 Query: 135 HRDLKPNNLLL---DENGVLK--LADFGLAKSFGSPNRAYTHQV---VTRWYRAPELLF- 185 HRDLKP+N+L+ + +G +K ++DFGL K +++ + T + APE+L Sbjct: 125 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 184 Query: 186 -GARMYGVGVDMWAVGCIL 203 VD+++ GC+ Sbjct: 185 DCKENPTYTVDIFSAGCVF 203 >3MDY-A nrPDB Length = 337 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 109/256 (42%), Gaps = 46/256 (17%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ AK+ + + +G+G++ V+ + + V K+ +E T + + L Sbjct: 33 RTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAV-----KVFFTTEEASWFRETEIYQTVL 87 Query: 66 LQELSHPNIIGLLDA----FGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLM 120 ++ H NI+G + A G + + L+ D+ E L +K +L AY Sbjct: 88 MR---HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYS-- 142 Query: 121 TLQGLEYLHQH--------WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--- 169 ++ GL +LH I HRDLK N+L+ +NG +AD GLA F S Sbjct: 143 SVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIP 202 Query: 170 -THQVVTRWYRAPELL------------FGARMYGVGVDMWAVG--CILAELL--LRVPF 212 +V T+ Y PE+L A MY G+ +W V C+ ++ ++P+ Sbjct: 203 PNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPY 262 Query: 213 ---LPGDSDLDQLTRI 225 +P D + + I Sbjct: 263 HDLVPSDPSYEDMREI 278 >4H1J-A nrPDB Length = 293 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 83/196 (42%), Gaps = 11/196 (5%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGI---NRTALREIKLLQELSHPN 73 LGEG F VY+ N +KI + ++ KD + E +++ L HP+ Sbjct: 31 ILGEGFFGEVYEGVYTNHKG----EKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPH 86 Query: 74 IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 I+ L+ + ++ + +L ++ N L + Y L + + YL Sbjct: 87 IVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINC 146 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVTRWYRAPELLFGARMYG 191 +HRD+ N+L+ +KL DFGL++ + +A ++ +W + F R + Sbjct: 147 VHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINF--RRFT 204 Query: 192 VGVDMWAVGCILAELL 207 D+W + E+L Sbjct: 205 TASDVWMFAVCMWEIL 220 >3LMG-A nrPDB Length = 344 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 90/202 (44%), Gaps = 15/202 (7%) Query: 14 KLDFLGEGQFATVYKA----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 KL LG G F TV+K ++ V IK I+ ++ + L + L Sbjct: 35 KLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLA----IGSL 90 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 H +I+ LL S++ LV ++ L ++ + L P + + + +G+ YL Sbjct: 91 DHAHIVRLL-GLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYL 149 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH---QVVTRWYRAPELLF 185 +H ++HR+L N+LL +++ADFG+A ++ + + +W + F Sbjct: 150 EEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHF 209 Query: 186 GARMYGVGVDMWAVGCILAELL 207 G Y D+W+ G + EL+ Sbjct: 210 GK--YTHQSDVWSYGVTVWELM 229 >4Y83-A nrPDB Length = 332 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 61/283 (21%), Positives = 110/283 (38%), Gaps = 47/283 (16%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 DF+ G F VY A+D T + +A K I +++ ++++ H NI Sbjct: 79 DFIPRGAFGKVYLAQDIKTKKRMACKLIP----------VDQFKPSDVEIQACFRHENIA 128 Query: 76 GLLDAFGHKSNISLVFDFME--TDLEVI-----IKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L A + L + E + LE + +++ ++ H+ L+GL++L Sbjct: 129 ELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHV-------LKGLDFL 181 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H ++H D+KP+N++ + L DFGL+ T Y +PE++ R Sbjct: 182 HSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CR 239 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 + D++++G L + P P +++P + P Y+ Sbjct: 240 GHSTKADIYSLGATLIHMQTGTP--------------------PWVKRYP-RSAYPSYLY 278 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 PL I + +LI+ NP R A LK Sbjct: 279 IIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLK 321 >3G2F-A nrPDB Length = 336 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 100/233 (42%), Gaps = 40/233 (17%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L+ +G G++ VYK + VA+K +R ++ IN + + L++ H NI Sbjct: 18 LELIGRGRYGAVYKG--SLDERPVAVKVFSFANR---QNFINEKNIYRVPLME---HDNI 69 Query: 75 IGLL------DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 + A G + ++ + L + ++ S A+ + +GL YL Sbjct: 70 ARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVT--RGLAYL 127 Query: 129 H------QHW---ILHRDLKPNNLLLDENGVLKLADFGLAKSF--------GSPNRAYTH 171 H H+ I HRDL N+L+ +G ++DFGL+ G + A Sbjct: 128 HTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAIS 187 Query: 172 QVVTRWYRAPELLFGA------RMYGVGVDMWAVGCILAELLLRVP-FLPGDS 217 +V T Y APE+L GA VDM+A+G I E+ +R PG+S Sbjct: 188 EVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGES 240 >3BBT-B nrPDB Length = 328 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 90/203 (44%), Gaps = 15/203 (7%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIK-KIKLGHRSEAKDGINRTALREIKLLQELSH 71 +++ LG G F TVYK + V I IK+ + + N + E ++ + H Sbjct: 18 KRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA-NVEFMDEALIMASMDH 76 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD--LEVII--KDNSLVLTPSHIKAYMLMTLQGLEY 127 P+++ LL I LV M LE + KDN + + + + +G+ Y Sbjct: 77 PHLVRLL-GVCLSPTIQLVTQLMPHGCLLEYVHEHKDN---IGSQLLLNWCVQIAKGMMY 132 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH---QVVTRWYRAPELL 184 L + ++HRDL N+L+ +K+ DFGLA+ + Y ++ +W + Sbjct: 133 LEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIH 192 Query: 185 FGARMYGVGVDMWAVGCILAELL 207 + R + D+W+ G + EL+ Sbjct: 193 Y--RKFTHQSDVWSYGVTIWELM 213 >5M07-A nrPDB Length = 276 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 84/217 (38%), Gaps = 23/217 (10%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 MAL Y + LG VY + A+K L A D R Sbjct: 21 MALASGVTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKV--LSPAMAADDEFRRRFQ 78 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDN-SLVLTPSHIKAYM 118 RE ++ L HP+I+ + D + + D+++ D + D VL + A + Sbjct: 79 RETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIV 138 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV----LKLADFGLAKSFGSPNRAYTHQVV 174 L+Y HQ +LHRD+ P N++L + LADFG+A P+ Sbjct: 139 TAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIAS---QPS-------- 187 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVP 211 Y APEL GA + G D +A+ L P Sbjct: 188 ---YPAPELSAGADVDGR-ADQYALALTAIHLFAGAP 220 >4M69-B nrPDB Length = 283 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 10/166 (6%) Query: 62 EIKLLQELSHPNIIGL----LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAY 117 EIK +++ PNI+ + +D S+V ++ E + D LT S Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 117 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR- 176 +L +GL LH LHR++ ++ L+ +KLA F L+K+ S +R R Sbjct: 118 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 177 Query: 177 ---WYRAPELLFGA-RMYGVGVDMWAVGCILAELLL-RVPFLPGDS 217 Y +PE L +Y + ++++ G +L E+ ++PF DS Sbjct: 178 SSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS 223 >3ZBF-A nrPDB Length = 322 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 99/233 (42%), Gaps = 32/233 (13%) Query: 17 FLGEGQFATVYKARDKNTNQI------VAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LG G F VY+ + + VA+K +K G + K L+E L+ + + Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEF----LKEAHLMSKFN 95 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLV------LTPSHIKAYMLMTLQ 123 HPNI+ L ++ + ME DL ++ + LT + + + Sbjct: 96 HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISK 155 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENG-----VLKLADFGLAKSFGSPNRAYTHQ----VV 174 G YL + +HRDL N L+ ++K+ DFGLA+ N Y + + Sbjct: 156 GCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI-YKNDYYRKRGEGLLP 214 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRI 225 RW APE L ++ D+W+ G ++ E+L P+ P S+LD L + Sbjct: 215 VRWM-APESLMDG-IFTTQSDVWSFGILIWEILTLGHQPY-PAHSNLDVLNYV 264 >3G0E-A nrPDB Length = 336 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/238 (23%), Positives = 100/238 (42%), Gaps = 37/238 (15%) Query: 18 LGEGQF-----ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-SH 71 LG G F AT Y + VA+K +K ++ + + E+K+L L +H Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL----MSELKVLSYLGNH 109 Query: 72 PNIIGLLDAFGHKSNISLVFDFM-ETDLEVII--KDNSLVLTPSH--------------- 113 NI+ LL A ++ ++ DL + K +S + + + Sbjct: 110 MNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLED 169 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH-- 171 + ++ +G+ +L +HRDL N+LL + K+ DFGLA+ + + Sbjct: 170 LLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGN 229 Query: 172 -QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR----VPFLPGDSDLDQLTR 224 ++ +W APE +F +Y D+W+ G L EL P +P DS ++ + Sbjct: 230 ARLPVKW-MAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 285 >3SV0-A nrPDB Length = 483 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 20/179 (11%) Query: 18 LGEGQFATVYKARDKNTNQIVAIK--KIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 +G G F +Y + TN+ VAIK +K H L E K+ + L I Sbjct: 15 IGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ---------LLYESKIYRILQGGTGI 65 Query: 76 GLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + FG + + + LV D + LE + S L+ + + +E++H L Sbjct: 66 PNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFL 125 Query: 135 HRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 HRD+KP+N L+ + + DFGLAK + + THQ + YR + L G Y Sbjct: 126 HRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTS---THQHIP--YRENKNLTGTARY 179 >3M42-A nrPDB Length = 299 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 69/288 (23%), Positives = 110/288 (38%), Gaps = 60/288 (20%) Query: 59 ALREIKLLQELSH-PNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDNS-LVLTP 111 A RE++L S P+I+ ++D + G K + ++ +L I+D T Sbjct: 57 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 116 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRA 168 M + ++YLH I HRD+KP NLL N +LKL DFG AK Sbjct: 117 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEK-- 174 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 Y DMW++G I+ LL P + L ++ +T Sbjct: 175 ---------------------YDKSCDMWSLGVIMYILLCGYPPFYSNHGL-AISPGMKT 212 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 + ++P+ P++ S +++ LI+ L P R+T T+ Sbjct: 213 RIRMGQYEFPN----PEW---------------SEVSEEVKMLIRNLLKTEPTQRMTITE 253 Query: 289 ALKMKYFSNRPGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 F N P ++P+ P LKE +K + T AL Sbjct: 254 ------FMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 295 >5WNL-A nrPDB Length = 342 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/160 (31%), Positives = 77/160 (48%), Gaps = 14/160 (8%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A + + +G G F VYK R + +AIK H D R L E E Sbjct: 19 AGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH----VDDRERMELLEEAKKME 74 Query: 69 LSHPNIIGLLDAFG-HKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLM-TLQGL 125 ++ I L +G + + LV ++MET LE ++ L P ++ ++ T G+ Sbjct: 75 MAKFRYI--LPVYGICQEPVGLVMEYMETGSLEKLLASEPL---PWDLRFRIVHETAVGM 129 Query: 126 EYLH--QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG 163 +LH +LH +LKP N+LLD + +K++DFGLAK G Sbjct: 130 NFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNG 169 >4XLV-A nrPDB Length = 328 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 90/203 (44%), Gaps = 16/203 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA-LREIKLLQELSHPNIIG 76 LG+G F VY+ ++ + A ++ + +E+ R L E +++ + +++ Sbjct: 47 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 106 Query: 77 LLDAFGHKSNISLVFDFM-ETDLEVIIK------DNSLVLTPSHIKAYMLMTLQ---GLE 126 LL +V + M DL+ ++ +N+ P ++ + M + G+ Sbjct: 107 LLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMA 166 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTHQVVTRWYRAPEL 183 YL+ +HRDL N ++ + +K+ DFG+ + + + + RW APE Sbjct: 167 YLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM-APES 225 Query: 184 LFGARMYGVGVDMWAVGCILAEL 206 L ++ DMW+ G +L E+ Sbjct: 226 LKDG-VFTTSSDMWSFGVVLWEI 247 >4BTF-A nrPDB Length = 469 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 10/166 (6%) Query: 62 EIKLLQELSHPNIIGL----LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAY 117 EIK +++ PNI+ + +D S+V ++ E + D LT S Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL 303 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR- 176 +L +GL LH LHR++ ++ L+ +KLA F L+K+ S +R R Sbjct: 304 VLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERS 363 Query: 177 ---WYRAPELLFGA-RMYGVGVDMWAVGCILAELLL-RVPFLPGDS 217 Y +PE L +Y + ++++ G +L E+ ++PF DS Sbjct: 364 SSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS 409 >2WTK-B nrPDB Length = 373 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 85/351 (24%), Positives = 143/351 (40%), Gaps = 59/351 (16%) Query: 12 YEKLDFLGEG--QFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR-EIKLLQE 68 YE L +G+G TV AR K T + V +++I L EA T L+ E+ + + Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINL----EACSNEMVTFLQGELHVSKL 66 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKD-----NSLVLTPSHIKAYMLM- 120 +HPNI+ F + + +V FM + ++I N L + AY+L Sbjct: 67 FNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAI------AYILQG 120 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW--- 177 L+ L+Y+H +HR +K +++L+ +G + L+ GL + + +VV + Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKY 178 Query: 178 ------YRAPELL-FGARMYGVGVDMWAVGCILAELLL-RVPF--LPGDSDL-----DQL 222 + +PE+L + Y D+++VG EL VPF +P L + Sbjct: 179 SVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTV 238 Query: 223 TRIFETLGTPTEE------QWPDMCSLPDYVTFKS-------FPGIPLHHIFSAAGDDLL 269 + +T P EE + L D +T + P P H FS Sbjct: 239 PCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSP---HFH 295 Query: 270 DLIQGLFLFNPCARITATQALKMKYFSN--RPGPTPGCQLPRPNCPVETLK 318 ++ NP AR +A+ L +F R +L RP P+ + Sbjct: 296 HFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFE 346 >5L2Q-C nrPDB Length = 320 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 31/90 (34%), Positives = 48/90 (53%), Gaps = 2/90 (2%) Query: 125 LEYLHQHWILHRDLKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 +E LHQ I+HRDLK N++L++ + + +F L K S Q + Y +P++ Sbjct: 166 VEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDV 225 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPF 212 L G G DMWA+G +L +L + PF Sbjct: 226 LSGRPYRGKPSDMWALGVVLFTMLYGQFPF 255 >5VC6-A nrPDB Length = 289 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 75/155 (48%), Gaps = 9/155 (5%) Query: 2 ALDVKSR-AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 A +KSR + +L+ +G G+F +V+K + I AIK+ K + A + AL Sbjct: 2 AGSMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSK---KPLAGSVDEQNAL 58 Query: 61 REIKLLQELS-HPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLT---PSHIK 115 RE+ L H +++ A+ ++ + ++ L I +N +++ + +K Sbjct: 59 REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELK 118 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV 150 +L +GL Y+H ++H D+KP+N+ + + Sbjct: 119 DLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSI 153 >3REP-A nrPDB Length = 271 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 97/213 (45%), Gaps = 22/213 (10%) Query: 12 YEKLDFL---GEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +++L+FL E ++K R + + +V + K++ +++D N R L+ Sbjct: 9 FKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECPR----LRI 63 Query: 69 LSHPNIIGLLDAFGH--KSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 SHPN++ +L A + +L+ +M + V+ + + V+ S + L +G Sbjct: 64 FSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARG 123 Query: 125 LEYLH--QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 + +LH + I L ++++DE+ +++ + SF SP R Y V APE Sbjct: 124 MAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYAPAWV-----APE 178 Query: 183 LLFGA--RMYGVGVDMWAVGCILAELLLR-VPF 212 L DMW+ +L EL+ R VPF Sbjct: 179 ALQKKPEDTNRRSADMWSFAVLLWELVTREVPF 211 >5FQD-C nrPDB Length = 341 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 73/165 (44%), Gaps = 12/165 (7%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +Y+ + +G G F +Y A + + VA+K E++ + L E KL + L Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK-------LESQKARHPQLLYESKLYKILQ 72 Query: 71 HPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 I + +G + + + LV D + LE + S T + + +EY+H Sbjct: 73 GGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVH 132 Query: 130 QHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTH 171 +HRD+KP+N L+ L L DFGLAK + NR H Sbjct: 133 TKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY-RDNRTRQH 176 >5AR8-A nrPDB Length = 326 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/152 (28%), Positives = 70/152 (46%), Gaps = 9/152 (5%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L +L G TV AR + VA+K + + + D + LRE ++L + I Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHI--HTPLLDSERKDVLREAEILHKARFSYI 94 Query: 75 IGLLDAFGHKSNISLVFDFMETDL--EVIIKDNSL--VLTPSHIKAYMLMTLQGLEYLHQ 130 + +L + +V ++M E++ + V P + + L G+ YLH Sbjct: 95 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIAL-GVNYLHN 153 Query: 131 HW--ILHRDLKPNNLLLDENGVLKLADFGLAK 160 +LH DLK N+LLD +K+ADFGL+K Sbjct: 154 MTPPLLHHDLKTQNILLDNEFHVKIADFGLSK 185 >4MWI-A nrPDB Length = 294 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 99/217 (45%), Gaps = 21/217 (9%) Query: 17 FLGEGQFATVYKAR-DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 L E + +T+YK + I KK++ G + + N+ EIK +++ PNI+ Sbjct: 31 LLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNK----EIKTMKKFESPNIL 86 Query: 76 GL----LDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + +D S+V ++ E T E++ ++ L L + +L +GL LH Sbjct: 87 RIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMV--LVLGAARGLYRLH 144 Query: 130 QHWI--LHRDLKPNNLLLDENGVLKLADFGLAKSFGS----PNRAYTHQVVTRWYRAPEL 183 LH ++ +N L+ + +KLA F L K+ S R T +V + Y +P+ Sbjct: 145 HSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQE 204 Query: 184 LFGA-RMYGVGVDMWAVGCILAELLL-RVPFLPGDSD 218 L Y V ++++ G +L E+ +PF +S+ Sbjct: 205 LEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSE 241 >5E8V-A nrPDB Length = 316 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 71/296 (23%), Positives = 128/296 (43%), Gaps = 39/296 (13%) Query: 17 FLGEGQFATVYKAR-DKNTNQIVAIKKIKLGHRSE-AKDGINRTALREIKLLQELSHPNI 74 +G+G+FA VYKA+ +NT++ +K+ E A + +I L H NI Sbjct: 16 LVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINL----KHENI 71 Query: 75 IGLLDAFGHKSNIS----LVFDF-METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + L A K+ + L+ F + +L+ + + V++ ++ +G+ +LH Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH--VISWEDLRKLGSSLARGIAHLH 129 Query: 130 QHW---------ILHRDLKPNNLLLDENGVLKLADFGLA----KSFGSPNRAYTHQVVTR 176 I+HRDLK +N+L+ + L DFGL+ + + A + QV T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 177 WYRAPELLFGA-RMYGV----GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 Y APE+L A + V D++++ +L E+ R + D + G+ Sbjct: 190 RYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEP------PFGS 243 Query: 232 PTEEQWPDMCSLPDYVTFKS-FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 E P + S+ D V + P IP + + + + + +P AR+TA Sbjct: 244 KVREH-PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTA 298 >2RSV-A nrPDB Length = 403 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 3/89 (3%) Query: 76 GLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 GL D G KS ++ D +DL+ I + N+ + + L L LEY+H+H +H Sbjct: 124 GLHDKNG-KSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVH 182 Query: 136 RDLKPNNLLLDENG--VLKLADFGLAKSF 162 D+K +NLLL+ + L D+GLA + Sbjct: 183 GDIKASNLLLNYKNPDQVYLVDYGLAYRY 211 >2LAV-A nrPDB Length = 361 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 72/167 (43%), Gaps = 27/167 (16%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII-- 75 +G+G F +Y A D N+++ V + E D N E+K Q + P I Sbjct: 43 IGQGGFGCIYLA-DMNSSESVG-SDAPCVVKVEPSD--NGPLFTELKFYQRAAKPEQIQK 98 Query: 76 ------------------GLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAY 117 GL D G KS ++ D +DL+ I + N+ + + Sbjct: 99 WIRTRKLKYLGVPKYWGSGLHDKNG-KSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQL 157 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSF 162 L L LEY+H+H +H D+K +NLLL+ + L D+GLA + Sbjct: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 >2C47-A nrPDB Length = 313 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 72/158 (45%), Gaps = 19/158 (12%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F + ++ TN+ VAIK + R+ E + ++LS + Sbjct: 12 IGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQ-------LHLEYRFYKQLSATEGVPQ 64 Query: 78 LDAFG--HKSNISLVFDFMETDLEVIIK--DNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 + FG K N ++V + + LE + D + L + A L+T +EY+H + Sbjct: 65 VYYFGPCGKYN-AMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITR--MEYVHTKSL 121 Query: 134 LHRDLKPNNLLLDENGV-----LKLADFGLAKSFGSPN 166 ++RD+KP N L+ G + + DFGLAK + P Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPE 159 >5OAT-A nrPDB Length = 411 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/170 (28%), Positives = 72/170 (42%), Gaps = 37/170 (21%) Query: 71 HPNIIGLLDAF---------------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIK 115 HPNI+ + F G N+SL D + + L PS Sbjct: 98 HPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNL---QSFLSTAPSTRT 154 Query: 116 AYMLMTL--QGLEYLHQHWILHRDLKPNNLLLD----ENGVLKLADFG--LAKSFGSPNR 167 + +L+ +G+ ++ H I HRDLK +NLLLD E+ +L ++DFG LA + Sbjct: 155 SLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSL 214 Query: 168 AYTHQVVTR----WYRAPELL------FGARMYGVGVDMWAVGCILAELL 207 YT + + APE++ F Y D+WAVG I E+ Sbjct: 215 PYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-KADLWAVGAIAYEIF 263 >4XHH-A nrPDB Length = 403 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 75/178 (42%), Gaps = 16/178 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F +Y + + + VAI+ + R D E ++ + LS I Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLD-------YESRVYKYLSGGVGIPF 67 Query: 78 LDAFGHKSNI-SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + FG + ++V D + LE + + + L + ++Y+H +HR Sbjct: 68 IRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFIHR 127 Query: 137 DLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 D+KP+N L+ + + DFGL+K + N TH+ + YR + L G Y Sbjct: 128 DIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFN---THRHIP--YRENKSLTGTARYA 180 >5VDK-A nrPDB Length = 297 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 35/189 (18%) Query: 9 AKRYEK----LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 A RYEK ++ +G G+F TVYK + + AIK+ ++ + +AL E+ Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR---SMKTFTELSNENSALHEVY 66 Query: 65 LLQELSH-PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLV---LTPSHIKAYML 119 L H P+++ ++ ++ + ++ L+ I +N+ +K +L Sbjct: 67 AHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILL 126 Query: 120 MTLQGLEYLHQHWILHRDLKPNNL-----------------------LLDENGVLKLADF 156 GL Y+H ++H D+KP+N+ L N + K+ D Sbjct: 127 QISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDL 186 Query: 157 GLAKSFGSP 165 G A S P Sbjct: 187 GHATSINKP 195 >3AOX-A nrPDB Length = 344 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 54/247 (21%), Positives = 99/247 (40%), Gaps = 27/247 (10%) Query: 18 LGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 LG G F VY+ + N + + L +D ++ L E ++ + +H NI Sbjct: 55 LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELD--FLMEALIISKFNHQNI 112 Query: 75 IGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTL--------QGL 125 + + ++ + M DL+ +++ PS + ++ L G Sbjct: 113 VRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP--RPSQPSSLAMLDLLHVARDIACGC 170 Query: 126 EYLHQHWILHRDLKPNNLLLDENG---VLKLADFGLAKSFGSPN---RAYTHQVVTRWYR 179 +YL ++ +HRD+ N LL G V K+ DFG+A+ + + + +W Sbjct: 171 QYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW-- 228 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 P F ++ D W+ G +L E + + ++P S +Q F T G + P Sbjct: 229 MPPEAFMEGIFTSKTDTWSFGVLLWE-IFSLGYMPYPSKSNQEVLEFVTSGGRMDP--PK 285 Query: 240 MCSLPDY 246 C P Y Sbjct: 286 NCPGPVY 292 >4XHL-A nrPDB Length = 394 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 74/178 (41%), Gaps = 16/178 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F +Y + + + VAI+ + R D E ++ + LS I Sbjct: 15 IGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLD-------YESRVYRYLSGGVGIPF 67 Query: 78 LDAFGHKSNI-SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + FG + ++V D + LE + + + L ++Y+H +HR Sbjct: 68 IRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHR 127 Query: 137 DLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 D+KP+N L+ + + DFGL+K + N TH+ + YR + L G Y Sbjct: 128 DIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFN---THRHIP--YRENKSLTGTARYA 180 >2CHL-A nrPDB Length = 351 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 66/278 (23%), Positives = 115/278 (41%), Gaps = 38/278 (13%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F + ++ TN+ VAIK + R+ E + ++L + I Sbjct: 38 IGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQ-------LHLEYRFYKQLGSGDGIPQ 90 Query: 78 LDAFG--HKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + FG K N ++V + + LE + + + + + +EY+H +++ Sbjct: 91 VYYFGPCGKYN-AMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIY 149 Query: 136 RDLKPNNLLLDENG-----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG-ARM 189 RD+KP N L+ G V+ + DF LAK + P T + + YR + L G AR Sbjct: 150 RDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPE---TKKHIP--YREHKSLTGTARY 204 Query: 190 YGVGV----------DMWAVGCILAELLL-RVPF--LPGDSDLDQLTRIFET-LGTPTE- 234 + D+ A+G + L +P+ L D+ ++ +I +T TP E Sbjct: 205 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 264 Query: 235 --EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 E +P+M + YV F P + DL D Sbjct: 265 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFD 302 >2CMW-A nrPDB Length = 310 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 37/162 (22%), Positives = 65/162 (40%), Gaps = 28/162 (17%) Query: 18 LGEGQFATVYKARDKNTNQIVAIK---------KIKLGHRSEAKDGINRTALREIKLLQE 68 +G G F + ++ TN+ VAIK ++ L +R + G L ++ Sbjct: 8 IGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGP 67 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 N ++V + + LE + T + + L +EY+ Sbjct: 68 CGKYN--------------AMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYV 113 Query: 129 HQHWILHRDLKPNNLLLDENG-----VLKLADFGLAKSFGSP 165 H +++RD+KP N L+ G V+ + DFGLAK + P Sbjct: 114 HSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDP 155 >5CLR-A nrPDB Length = 451 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 34/66 (51%), Gaps = 3/66 (4%) Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 M+ ++ H+ ++HRDLKP N++LD + L DFG + S P A T Sbjct: 182 MISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPKPASWG---TAS 238 Query: 178 YRAPEL 183 Y APEL Sbjct: 239 YLAPEL 244 >3MY0-A nrPDB Length = 305 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 77/334 (23%), Positives = 128/334 (38%), Gaps = 73/334 (21%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ A++ ++ +G+G++ V++ + V I R E ++ RE ++ Sbjct: 4 RTVARQVALVECVGKGRYGEVWRGLWHGESVAVKI----FSSRDE------QSWFRETEI 53 Query: 66 LQE--LSHPNIIGLL--DAFGHKSNISL-----------VFDFMETDLEVIIKDNSLVLT 110 L H NI+G + D S+ L ++DF++ L Sbjct: 54 YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ----------TLE 103 Query: 111 PSHIKAYMLMTLQGLEYLH--------QHWILHRDLKPNNLLLDENGVLKLADFGLA--K 160 P + GL +LH + I HRD K N+L+ N +AD GLA Sbjct: 104 PHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMH 163 Query: 161 SFGSP--NRAYTHQVVTRWYRAPELL--------FGARMYGVGVDMWAVGCILAELLLRV 210 S GS + +V T+ Y APE+L F + + D+WA G +L E+ R Sbjct: 164 SQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKW---TDIWAFGLVLWEIARRT 220 Query: 211 PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGD 266 + I E P + P+ S D + P IP Sbjct: 221 I----------VNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLS 270 Query: 267 DLLDLIQGLFLFNPCARITATQALK-MKYFSNRP 299 L +++ + NP AR+TA + K ++ SN P Sbjct: 271 GLAQMMRECWYPNPSARLTALRIKKTLQKISNSP 304 >1CSN-A nrPDB Length = 298 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 71/156 (45%), Gaps = 17/156 (10%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH-PNIIG 76 +GEG F +++ + NQ VAIK RS+A R R KLL + PN+ Sbjct: 18 IGEGSFGVIFEGTNLLNNQQVAIKFEP--RRSDAPQL--RDEYRTYKLLAGCTGIPNVY- 72 Query: 77 LLDAFGHKS--NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 FG + N+ LV D + LE ++ + + L ++ +H+ ++ Sbjct: 73 ---YFGQEGLHNV-LVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLV 128 Query: 135 HRDLKPNNLLL-----DENGVLKLADFGLAKSFGSP 165 +RD+KP+N L+ ++ + DFG+ K + P Sbjct: 129 YRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDP 164 >4TN6-A nrPDB Length = 318 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 25/70 (35%), Positives = 38/70 (54%), Gaps = 8/70 (11%) Query: 125 LEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 +EY+H +HRD+KP+N L+ + ++ + DFGLAK + A THQ + YR Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY---RDARTHQHIP--YREN 170 Query: 182 ELLFGARMYG 191 + L G Y Sbjct: 171 KNLTGTARYA 180 >5UU1-A nrPDB Length = 324 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/166 (27%), Positives = 72/166 (43%), Gaps = 21/166 (12%) Query: 18 LGEGQFATVYKA-----RDKNTNQIVAIK---------KIKLGHRSEAKDGINRTALREI 63 +G G F +Y A +K+ +V ++ ++K R KD I + R Sbjct: 24 IGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIER-- 81 Query: 64 KLLQELSHPNIIGL-LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 K L L P G L F +S +V + + DL+ I N S + + L Sbjct: 82 KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNG-TFKKSTVLQLGIRML 140 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSFGSPN 166 LEY+H++ +H D+K NLLL + LAD+GL+ + PN Sbjct: 141 DVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY-CPN 185 >4L00-A nrPDB Length = 304 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/234 (22%), Positives = 92/234 (39%), Gaps = 23/234 (9%) Query: 16 DFLGEGQFATVYKAR------DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + LG G +Y D+ T++ IK I L + I+ +++++ Sbjct: 31 EHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVI-LKVLDPSHRDISLAFFEAASMMRQV 89 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 SH +I+ L +V +F+E L++ + S VLT L YL Sbjct: 90 SHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYL 149 Query: 129 HQHWILHRDLKPNNLLLDENGV-------LKLADFGLAKSFGSPNRAYTHQVVTR--WYR 179 ++H ++ NLLL G+ +KL+D G+ + S + + R W Sbjct: 150 EDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLS-----RQECIERIPWI- 203 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT 233 APE + ++ V D W+ G L E+ D L + R +E+ P Sbjct: 204 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPV 257 >5J0A-A nrPDB Length = 300 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/191 (25%), Positives = 88/191 (46%), Gaps = 20/191 (10%) Query: 39 AIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM---E 95 A+KKI + + + E K+L+ L HPNI+G AF ++ SL E Sbjct: 41 AVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYR-AFTEANDGSLCLAMEYGGE 99 Query: 96 TDLEVIIKDN---SLVLTPSHIKAYMLMTL-QGLEYLHQH-WILHRDLKPNNLLLDEN-G 149 L +I++ S P+ I + + + +GL+YLHQ +LH D+K +N+++ + Sbjct: 100 KSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE 159 Query: 150 VLKLADFGLA------KSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCIL 203 +K+ D G++ P Y + T ++ E + + D++A G L Sbjct: 160 TIKICDVGVSLPLDENMEVTDPEACY---IGTEPWKPKEAVEENGVITDKADIFAFGLTL 216 Query: 204 AELL-LRVPFL 213 E++ L +P + Sbjct: 217 WEMMTLSIPHI 227 >6G4J-A nrPDB Length = 315 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 81/215 (37%), Gaps = 13/215 (6%) Query: 21 GQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH-------PN 73 G T+ K K N IV + + GH + + + E+ +L+ S P+ Sbjct: 25 GNTYTLRKQLGKGANGIVYLAETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPS 84 Query: 74 IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 DA+ +N + F ME ++ I M+ L L LHQ Sbjct: 85 FFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGW 144 Query: 134 LHRDLKPNNLLL-DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 + DLKP+NL++ ++ D G G + YT +Y +G R Sbjct: 145 IFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTE-----FYDRGYWGYGTRKAEP 199 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 D++AV I+ + + F + +QL + E Sbjct: 200 SYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIE 234 >5X18-A nrPDB Length = 295 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/180 (27%), Positives = 78/180 (43%), Gaps = 20/180 (11%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +GEG F +++ + VAIK ++EA R + K+L PNI Sbjct: 15 IGEGSFGVLFEGTNMINGVPVAIKFEP--RKTEAPQ--LRDEYKTYKILN--GTPNI-PY 67 Query: 78 LDAFGHKS--NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 FG + NI LV D + LE + + + + + +E LH H +++ Sbjct: 68 AYYFGQEGLHNI-LVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIY 126 Query: 136 RDLKPNNLLLDENGV-----LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 RD+KP+N L+ G + L DFG+AK + P T Q + YR + L G Y Sbjct: 127 RDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPK---TKQHIP--YREKKSLSGTARY 181 >4IX6-A nrPDB Length = 350 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/47 (46%), Positives = 27/47 (57%), Gaps = 2/47 (4%) Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE--NGVLKLADFGLA 159 K M L L LH+ ++HRD+KP NL+ E GVLKL D G A Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 >4NT4-A nrPDB Length = 312 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 27/46 (58%), Gaps = 5/46 (10%) Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENG-----VLKLADFGLAKSF 162 L +EY+H +++RD+KP N L+ ++ + DFGLAK + Sbjct: 124 LHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 >4L68-A nrPDB Length = 340 Score = 35.0 bits (79), Expect = 0.048, Method: Compositional matrix adjust. Identities = 47/178 (26%), Positives = 78/178 (43%), Gaps = 10/178 (5%) Query: 47 HRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDN 105 H S K G R E+ L EL H N+ LL + LV+ +M L ++ N Sbjct: 71 HLSTCKLG-EREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSN 129 Query: 106 SLVLTPSHIKAYMLMTLQGLEYLHQHW---ILHRDLKPNNLLLDENGVLKLADFGLAK-- 160 L S L +GL +LH ILH+++ + +L+DE+ ++ D GLA+ Sbjct: 130 RGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLM 189 Query: 161 --SFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 S + + T + Y APE + + D++ +G +L EL + + G+ Sbjct: 190 VPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDVYGLGVVLLELATGLKAVGGE 246 >4NFN-A nrPDB Length = 309 Score = 33.9 bits (76), Expect = 0.094, Method: Compositional matrix adjust. Identities = 36/160 (22%), Positives = 67/160 (41%), Gaps = 17/160 (10%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 R++ L +G G F +Y+A D T + VA+K E+ + E+ +L++L Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALK-------VESAQQPKQVLKMEVAVLKKLQ 74 Query: 71 HPNIIGLLDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + + G + V ++ DL + L+ + + L+ +E Sbjct: 75 GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI--LESIE 132 Query: 127 YLHQHWILHRDLKPNNLLLDE----NGVLKLADFGLAKSF 162 +H LHRD+KP+N + + DFGLA+ + Sbjct: 133 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 >6J6I-B nrPDB Length = 351 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 25/43 (58%), Gaps = 3/43 (6%) Query: 123 QGLEYLHQHW---ILHRDLKPNNLLLDENGVLKLADFGLAKSF 162 + YLH + I+HRD+KP ++ LD+N KL+D + S Sbjct: 174 NAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISL 216 >4BTK-A nrPDB Length = 337 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 36/160 (22%), Positives = 67/160 (41%), Gaps = 17/160 (10%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 R++ L +G G F +Y+A D T + VA+K E+ + E+ +L++L Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALK-------VESAQQPKQVLKMEVAVLKKLQ 109 Query: 71 HPNIIGLLDAFGHKSNISLVFDFME----TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + + G + V ++ DL + L+ + + L+ +E Sbjct: 110 GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQI--LESIE 167 Query: 127 YLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSF 162 +H LHRD+KP+N + + DFGLA+ + Sbjct: 168 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 >6BQ8-A nrPDB Length = 152 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 25/111 (22%), Positives = 51/111 (45%), Gaps = 6/111 (5%) Query: 46 GHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFG---HKSNISLVFDFMETDLEVII 102 G ++A+D R LR + LL+ L + ++D + ++ + E I+ Sbjct: 1 GSTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFIL 60 Query: 103 KDNSLVLTPS---HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV 150 + +T S H + ++ TLQ EY + ++ D++ N++ +EN V Sbjct: 61 AKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDV 111 >6EWX-A nrPDB Length = 484 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 15/28 (53%), Positives = 19/28 (67%) Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLL 145 +L GLE+L +H I+HRDL NLLL Sbjct: 216 LLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >5VE6-A nrPDB Length = 492 Score = 32.3 bits (72), Expect = 0.30, Method: Compositional matrix adjust. Identities = 15/28 (53%), Positives = 19/28 (67%) Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLL 145 +L GLE+L +H I+HRDL NLLL Sbjct: 214 LLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >5VM9-A nrPDB Length = 862 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 3/51 (5%) Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 GV + MWA+ C + R L G + DQL +I + G P + Q P C Sbjct: 448 GVEIKMWAIACFATQRQCREEILKGFT--DQLRKISKDAGMPIQGQ-PCFC 495 >4CI6-B nrPDB Length = 643 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 6/61 (9%) Query: 127 YLHQHWILHRDLKPNNLLLDE-NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 +L + I+H D+KP N++ D +G + D GL G + +T ++APEL Sbjct: 171 HLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES-----FKAPELGV 225 Query: 186 G 186 G Sbjct: 226 G 226 >6EQI-C nrPDB Length = 433 Score = 31.6 bits (70), Expect = 0.49, Method: Compositional matrix adjust. Identities = 39/145 (26%), Positives = 63/145 (43%), Gaps = 30/145 (20%) Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENG-----VLKLADFGLA-----KSFGSPNRAYTH- 171 + + +++ H I HRDLK +N+L+D + + + DFG P R+ Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 172 QVVTRWYRAPEL------LFGARMYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTR 224 + R APE+ F Y D+WAVG I E+ + PF D + L++ Sbjct: 238 KGGNRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFY--DKTMKLLSK 294 Query: 225 IFETLGTPTEEQWPDMCSLPDYVTF 249 ++ EE P+ LPD + F Sbjct: 295 SYK------EEDLPE---LPDTIPF 310 >2A30-A nrPDB Length = 248 Score = 31.6 bits (70), Expect = 0.59, Method: Compositional matrix adjust. Identities = 16/35 (45%), Positives = 20/35 (57%) Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKL 153 L L+ L Y H+ W+LHR LK N L E +L L Sbjct: 190 LEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTL 224 >4Q1A-A nrPDB Length = 280 Score = 30.8 bits (68), Expect = 0.86, Method: Compositional matrix adjust. Identities = 16/35 (45%), Positives = 20/35 (57%) Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKL 153 L L+ L Y H+ W+LHR LK N L E +L L Sbjct: 222 LEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTL 256 >5UV4-A nrPDB Length = 311 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 88/205 (42%), Gaps = 21/205 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + +G T YKA N ++ +K +K G K+ REIK L + HPN++ Sbjct: 31 EIIGRSCHGTSYKATLDN-GYMLTVKWLKEGFAKSKKE-----FSREIKKLGSVRHPNLV 84 Query: 76 GLLDAF-GHKSNIS-LVFDF-----METDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L + G K + ++ D+ + T L + N L+ + + L+YL Sbjct: 85 PLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYL 144 Query: 129 HQHWIL-HRDLKPNNLLLDENGVLKL-ADFGLAKSFGSPNRAYTHQVVTR---WYRAPEL 183 H ++ H ++K +N+L+ + L D+ L + A QV+ Y PE Sbjct: 145 HNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMA--EQVLNAGALGYSPPEF 202 Query: 184 LFGAR-MYGVGVDMWAVGCILAELL 207 ++ + D++A G IL ELL Sbjct: 203 SSTSKPCPSLKSDVYAFGVILLELL 227 >3ENH-A nrPDB Length = 540 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 42/151 (27%), Positives = 73/151 (48%), Gaps = 23/151 (15%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIK-KIKLGHRSEAKDG---INRTA--LREIKLLQELS 70 +G+G A + RD + V IK ++K G+R E D +RTA R + L+++ Sbjct: 343 LIGKGAEADI--KRDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 71 HPN-IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 P I +D + +S + + D +I+DN + AY + + G LH Sbjct: 401 IPAPYIFDVDLDNKRIMMSYINGKLAKD---VIEDNLDI-------AYKIGEIVG--KLH 448 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 ++ ++H DL +N + D++ L + DFGL K Sbjct: 449 KNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >5DMZ-A nrPDB Length = 365 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 32/143 (22%), Positives = 59/143 (41%), Gaps = 6/143 (4%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LGEG FA VY+A + N +K L + A + ++ L+ + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKF 132 Query: 78 LDAFGHKSNISLV-----FDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 A ++ LV + + + + V+ + ++ + L +E +H Sbjct: 133 YSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCE 192 Query: 133 ILHRDLKPNNLLLDENGVLKLAD 155 I+H D+KP+N +L NG L+ D Sbjct: 193 IIHGDIKPDNFILG-NGFLEQDD 214 >1BXN-I nrPDB Length = 139 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 8/78 (10%) Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLF-NPCARITA------TQALKMKYFSNRPG 300 T+ G+P+ + AAG L+++ F N R+TA +++ M + NRP Sbjct: 46 TYWEMFGLPMFDLRDAAGI-LMEINNARNTFPNHYIRVTAFDSTHTVESVVMSFIVNRPA 104 Query: 301 PTPGCQLPRPNCPVETLK 318 PG +L R P TL+ Sbjct: 105 DEPGFRLVRQEEPGRTLR 122 >4O1O-A nrPDB Length = 717 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 18/29 (62%) Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADF 156 LH+ H+DL+P N+L+D LADF Sbjct: 458 LHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5BQ5-A nrPDB Length = 189 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 28/56 (50%), Gaps = 12/56 (21%) Query: 138 LKPNNLLLDENGVLKLADFGLAKSFGSPNRA-YTHQVVTRWYR-APELLFGARMYG 191 +KP L++DE G LKL PN A Y QV+ R Y AP +L + +G Sbjct: 99 VKPTVLIIDEMGYLKL----------DPNSAHYLFQVIARRYEHAPIILTSNKSFG 144 >6G18-v nrPDB Length = 552 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 20/39 (51%) Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN 166 L H ++H D NL+LDE+ + + DF S PN Sbjct: 219 LANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPN 257 >3BYV-A nrPDB Length = 377 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 56/125 (44%), Gaps = 22/125 (17%) Query: 94 METDLEVIIKDNSLVLTPSHIKAYMLMTLQG---LEYLHQHWILHRDLKPNNLLLDENGV 150 ++T EV++ +S + H A + +TLQ L LH + ++H L+P +++LD+ G Sbjct: 186 LQTFGEVLLSHSSTHKSLVH-HARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG 244 Query: 151 LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR------------MYGVGVDMWA 198 + L F G A V+R + PEL AR + D WA Sbjct: 245 VFLTGFEHLVRDG----ARVVSSVSRGFEPPEL--EARRATISYHRDRRTLMTFSFDAWA 298 Query: 199 VGCIL 203 +G ++ Sbjct: 299 LGLVI 303 >4NSP-A nrPDB Length = 250 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 35/70 (50%), Gaps = 3/70 (4%) Query: 97 DLEVIIKDNSLV-LTPSHIKAYMLMTLQG--LEYLHQHWILHRDLKPNNLLLDENGVLKL 153 +LEV+ +++ +V LT ++ ++ LE + Q L P LL+D NGVL Sbjct: 63 ELEVVYEESRMVSLTAPYVSGFLAFREVPFLLELVQQLREKEPGLMPQVLLVDGNGVLHH 122 Query: 154 ADFGLAKSFG 163 FG+A G Sbjct: 123 RGFGVACHLG 132 >4OAU-C nrPDB Length = 699 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 15/22 (68%) Query: 135 HRDLKPNNLLLDENGVLKLADF 156 H+DL+P N+L+D LADF Sbjct: 463 HQDLQPQNILIDSKKAAHLADF 484 >6FDN-A nrPDB Length = 320 Score = 28.5 bits (62), Expect = 5.1, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 20/39 (51%) Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN 166 L H ++H D NL+LDE+ + + DF S PN Sbjct: 219 LANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPN 257 >3DZO-A nrPDB Length = 413 Score = 27.3 bits (59), Expect = 8.9, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 4/66 (6%) Query: 94 METDLEVIIKDNSLVLTPSHIKAYMLMTLQG---LEYLHQHWILHRDLKPNNLLLDENGV 150 ++T EV++ +S + H A + +TLQ L LH + ++H L+P +++LD+ G Sbjct: 191 LQTFGEVLLSHSSTHKSLVH-HARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG 249 Query: 151 LKLADF 156 + L F Sbjct: 250 VFLTGF 255 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1UA2-A nrPDB 507 e-144 2BPM-A nrPDB 367 e-102 3NIZ-A nrPDB 355 2e-98 4AU8-A nrPDB 348 2e-96 6GU6-A nrPDB 343 6e-95 1V0B-A nrPDB 339 1e-93 4KRC-A nrPDB 338 3e-93 5EFQ-A nrPDB 334 2e-92 4NST-A nrPDB 325 2e-89 4QTB-A nrPDB 316 9e-87 2F9G-A nrPDB 316 1e-86 4EWQ-A nrPDB 315 2e-86 1CM8-A nrPDB 315 2e-86 5NGU-A nrPDB 314 2e-86 5Z33-A nrPDB 314 3e-86 3GC9-A nrPDB 311 3e-85 3OHT-A nrPDB 311 4e-85 4MYG-A nrPDB 310 6e-85 5JN2-A nrPDB 310 7e-85 1G3N-A nrPDB 310 7e-85 6DTL-A nrPDB 310 7e-85 3GC0-A nrPDB 309 2e-84 5G6V-A nrPDB 308 2e-84 4AGU-A nrPDB 308 3e-84 4BBM-A nrPDB 307 5e-84 4IC8-A nrPDB 306 1e-83 3NCG-A nrPDB 305 2e-83 4QNY-A nrPDB 304 5e-83 1JNK-A nrPDB 302 1e-82 4ZSG-A nrPDB 302 1e-82 3MIA-A nrPDB 301 2e-82 3OZ6-A nrPDB 301 3e-82 2XS0-A nrPDB 300 6e-82 3LIJ-A nrPDB 300 7e-82 3E7O-A nrPDB 298 2e-81 2W96-B nrPDB 297 4e-81 5AWM-A nrPDB 297 6e-81 4BGQ-A nrPDB 297 6e-81 4O2Z-A nrPDB 296 1e-80 3ZDU-A nrPDB 295 2e-80 3HZT-A nrPDB 294 4e-80 4MVF-A nrPDB 293 7e-80 3MA6-A nrPDB 292 1e-79 3DXN-A nrPDB 292 2e-79 4YZB-A nrPDB 292 2e-79 3DFA-A nrPDB 291 2e-79 3PG1-A nrPDB 286 8e-78 3COM-A nrPDB 284 3e-77 3FI2-A nrPDB 282 1e-76 5AIR-A nrPDB 282 1e-76 3Q5I-A nrPDB 282 2e-76 4JG6-A nrPDB 280 4e-76 4RGJ-A nrPDB 279 2e-75 2VN9-A nrPDB 276 8e-75 3RP9-A nrPDB 276 9e-75 5U6Y-A nrPDB 275 2e-74 3N9X-A nrPDB 274 3e-74 5Y86-A nrPDB 274 4e-74 5WAX-A nrPDB 274 4e-74 5FG8-A nrPDB 274 5e-74 4E7W-A nrPDB 273 7e-74 4LG4-A nrPDB 273 1e-73 2VZ6-A nrPDB 273 1e-73 3NIE-A nrPDB 272 1e-73 2V7O-A nrPDB 272 2e-73 6AO5-A nrPDB 270 8e-73 4UZD-A nrPDB 269 2e-72 2BDW-A nrPDB 268 2e-72 3BHH-A nrPDB 268 2e-72 5YKS-A nrPDB 268 3e-72 3SOA-A nrPDB 268 3e-72 3TAC-A nrPDB 267 5e-72 4FG9-A nrPDB 267 5e-72 2QNJ-A nrPDB 267 5e-72 3E3P-A nrPDB 266 9e-72 3D2K-A nrPDB 266 1e-71 2JC6-A nrPDB 265 1e-71 3MN3-A nrPDB 265 1e-71 3KK8-A nrPDB 265 1e-71 4NIF-A nrPDB 264 3e-71 3F3Z-A nrPDB 264 5e-71 5KZ7-A nrPDB 264 5e-71 4L42-A nrPDB 264 6e-71 2Y7J-A nrPDB 264 6e-71 5ES1-A nrPDB 263 7e-71 2I6L-A nrPDB 263 8e-71 5ZTN-A nrPDB 263 9e-71 3UC3-A nrPDB 262 1e-70 3EB0-A nrPDB 262 2e-70 5IG1-A nrPDB 262 2e-70 1PHK-A nrPDB 260 8e-70 4JXF-A nrPDB 260 8e-70 2YCR-A nrPDB 259 1e-69 4REW-A nrPDB 259 2e-69 2J90-A nrPDB 259 2e-69 3H4J-B nrPDB 258 3e-69 4CFH-A nrPDB 257 4e-69 4CFF-A nrPDB 256 8e-69 3ZUT-A nrPDB 256 8e-69 5EZV-A nrPDB 256 1e-68 4RED-A nrPDB 255 2e-68 3MV5-A nrPDB 255 3e-68 3I6U-A nrPDB 255 3e-68 4CZT-A nrPDB 254 3e-68 4RLP-A nrPDB 254 4e-68 2JAM-A nrPDB 254 4e-68 3UDB-A nrPDB 254 4e-68 2JDO-A nrPDB 253 8e-68 2UV2-A nrPDB 253 8e-68 5XZW-A nrPDB 253 9e-68 6FD3-A nrPDB 252 2e-67 2YAB-A nrPDB 252 2e-67 5KCV-A nrPDB 251 3e-67 2YZA-A nrPDB 251 4e-67 2HAK-A nrPDB 250 5e-67 6C9D-A nrPDB 250 9e-67 3DAK-A nrPDB 250 9e-67 4I6B-A nrPDB 249 1e-66 3DB8-A nrPDB 249 1e-66 3GUB-A nrPDB 249 1e-66 4D28-A nrPDB 249 1e-66 3UTO-A nrPDB 249 1e-66 6E9W-A nrPDB 249 2e-66 4B6L-A nrPDB 249 2e-66 2F57-A nrPDB 249 2e-66 5D9K-A nrPDB 248 3e-66 5X8I-B nrPDB 248 4e-66 3HDN-A nrPDB 247 4e-66 2A27-A nrPDB 247 4e-66 1KOA-A nrPDB 247 5e-66 2X4F-A nrPDB 247 6e-66 4QMW-A nrPDB 247 6e-66 5J5T-A nrPDB 247 6e-66 2XIK-A nrPDB 247 7e-66 2W4O-A nrPDB 247 7e-66 6FYV-A nrPDB 247 8e-66 5F9E-A nrPDB 246 9e-66 4FIE-A nrPDB 246 9e-66 5DBX-A nrPDB 246 1e-65 2Z7Q-A nrPDB 246 1e-65 4CRL-A nrPDB 245 1e-65 4KS7-A nrPDB 245 2e-65 1ZWS-A nrPDB 245 2e-65 4XBR-A nrPDB 245 2e-65 4CSV-A nrPDB 245 2e-65 4JDH-A nrPDB 245 2e-65 2Q0N-A nrPDB 245 2e-65 4PDS-A nrPDB 245 2e-65 6CMJ-A nrPDB 245 3e-65 6HXF-B nrPDB 244 4e-65 3Q53-A nrPDB 244 5e-65 4CQG-A nrPDB 244 5e-65 5D7A-A nrPDB 243 8e-65 3TXO-A nrPDB 243 8e-65 1FOT-A nrPDB 243 8e-65 3IS5-A nrPDB 242 1e-64 4FZF-B nrPDB 242 1e-64 6O6Q-A nrPDB 242 1e-64 6ED6-A nrPDB 242 1e-64 5JZN-A nrPDB 242 2e-64 3FXW-A nrPDB 242 2e-64 5DYK-A nrPDB 241 3e-64 2OU7-A nrPDB 239 1e-63 1VZO-A nrPDB 239 1e-63 4J52-A nrPDB 239 2e-63 4APC-A nrPDB 239 2e-63 5FET-A nrPDB 238 3e-63 6FDY-U nrPDB 238 3e-63 5YV8-A nrPDB 238 3e-63 1KOB-A nrPDB 237 6e-63 1NY3-A nrPDB 237 7e-63 5N23-A nrPDB 237 8e-63 3KA0-A nrPDB 236 8e-63 3HKO-A nrPDB 236 8e-63 2OZA-A nrPDB 236 1e-62 3ORZ-A nrPDB 235 1e-62 4D2V-A nrPDB 235 2e-62 5X3F-B nrPDB 235 2e-62 4YNZ-A nrPDB 234 4e-62 4WB7-A nrPDB 234 5e-62 4B8L-A nrPDB 234 5e-62 4RA4-A nrPDB 234 7e-62 4AW2-A nrPDB 233 7e-62 2HW6-A nrPDB 232 2e-61 3TKU-A nrPDB 232 2e-61 1U5R-A nrPDB 232 2e-61 5LOH-A nrPDB 231 4e-61 2GCD-A nrPDB 230 5e-61 4U41-A nrPDB 230 6e-61 4C0T-A nrPDB 229 1e-60 4AF3-A nrPDB 229 1e-60 6CKI-A nrPDB 229 2e-60 5XVU-A nrPDB 228 3e-60 2PVN-A nrPDB 227 6e-60 2WTK-C nrPDB 227 6e-60 6CQF-A nrPDB 227 7e-60 6BDL-A nrPDB 226 1e-59 4WNO-A nrPDB 226 1e-59 2WQN-A nrPDB 225 2e-59 5UNP-A nrPDB 225 2e-59 3A8W-A nrPDB 225 2e-59 2BRG-A nrPDB 225 2e-59 3KN6-A nrPDB 224 3e-59 6QAU-A nrPDB 224 5e-59 4MD7-E nrPDB 223 9e-59 3LM0-A nrPDB 223 9e-59 4XEY-B nrPDB 223 1e-58 2FO0-A nrPDB 223 1e-58 6E2O-A nrPDB 222 1e-58 5MJB-A nrPDB 222 2e-58 3NYO-A nrPDB 222 2e-58 3RAW-A nrPDB 222 2e-58 6HMD-A nrPDB 221 3e-58 3PFQ-A nrPDB 221 3e-58 2WO6-A nrPDB 220 6e-58 6NPU-A nrPDB 220 7e-58 4EBW-A nrPDB 220 8e-58 3VN9-A nrPDB 220 8e-58 6BXI-A nrPDB 220 9e-58 6DBN-A nrPDB 220 1e-57 2H8H-A nrPDB 219 1e-57 6EII-A nrPDB 219 1e-57 5L6P-A nrPDB 219 1e-57 2R2P-A nrPDB 219 1e-57 6F3F-A nrPDB 219 2e-57 2I0E-A nrPDB 219 2e-57 4FR4-A nrPDB 218 2e-57 3PPZ-A nrPDB 218 3e-57 4E93-A nrPDB 218 3e-57 2VD5-A nrPDB 218 3e-57 4P5Q-A nrPDB 218 3e-57 2Y6O-A nrPDB 218 3e-57 1JPA-A nrPDB 218 3e-57 5KKR-C nrPDB 218 3e-57 4OLI-A nrPDB 217 4e-57 3DKO-A nrPDB 217 5e-57 2J0K-A nrPDB 217 6e-57 2XYN-A nrPDB 217 6e-57 6CCF-A nrPDB 217 8e-57 3FME-A nrPDB 217 8e-57 4AN9-A nrPDB 217 8e-57 2XNP-A nrPDB 216 1e-56 3ALO-A nrPDB 216 1e-56 3EQC-A nrPDB 216 1e-56 3C51-A nrPDB 215 2e-56 6DBM-A nrPDB 215 3e-56 5SYS-A nrPDB 214 4e-56 1TKI-A nrPDB 214 4e-56 4E20-A nrPDB 214 5e-56 5H2U-A nrPDB 213 7e-56 4GS6-A nrPDB 213 7e-56 3V5Q-A nrPDB 213 7e-56 4AT3-A nrPDB 213 9e-56 4TNB-A nrPDB 213 9e-56 2DQ7-X nrPDB 213 1e-55 2VWV-A nrPDB 212 1e-55 5UUU-A nrPDB 212 2e-55 4LFI-A nrPDB 212 2e-55 3PVW-A nrPDB 211 4e-55 4EQM-A nrPDB 211 5e-55 4OTD-A nrPDB 210 8e-55 3KUL-B nrPDB 210 9e-55 5VO2-A nrPDB 210 1e-54 3A4O-X nrPDB 208 2e-54 1S9I-A nrPDB 208 2e-54 4IAN-A nrPDB 208 2e-54 4PDO-A nrPDB 208 2e-54 4UYA-A nrPDB 208 3e-54 6GQK-A nrPDB 207 4e-54 3M42-A nrPDB 207 6e-54 3QGY-A nrPDB 206 1e-53 5KMM-A nrPDB 206 1e-53 5HI2-A nrPDB 205 2e-53 1ZXE-A nrPDB 205 2e-53 4CRS-A nrPDB 205 2e-53 3ORP-A nrPDB 205 2e-53 3SXS-A nrPDB 203 6e-53 4UY9-A nrPDB 203 6e-53 4YHJ-A nrPDB 203 6e-53 3Q4U-A nrPDB 203 8e-53 4XLV-A nrPDB 203 1e-52 6FEX-A nrPDB 203 1e-52 1K9A-A nrPDB 203 1e-52 3DLS-A nrPDB 202 1e-52 3DTC-A nrPDB 202 2e-52 3TT0-A nrPDB 202 2e-52 6GVJ-A nrPDB 202 2e-52 2W1I-A nrPDB 202 2e-52 5HIE-A nrPDB 202 2e-52 2PL0-A nrPDB 202 3e-52 3IO7-A nrPDB 202 3e-52 6BSD-A nrPDB 201 3e-52 3OMV-A nrPDB 201 3e-52 4H1J-A nrPDB 201 3e-52 1FVR-A nrPDB 201 3e-52 5X5O-A nrPDB 201 4e-52 6FER-A nrPDB 201 4e-52 1LUF-A nrPDB 201 4e-52 4XUF-A nrPDB 201 4e-52 5A46-A nrPDB 200 6e-52 5B2L-A nrPDB 200 6e-52 5X02-A nrPDB 200 7e-52 3GQL-A nrPDB 200 1e-51 4HVI-A nrPDB 199 1e-51 4K33-A nrPDB 199 1e-51 1BYG-A nrPDB 199 1e-51 3HMP-A nrPDB 198 2e-51 2WTK-B nrPDB 198 2e-51 4XCU-A nrPDB 198 2e-51 4KIK-B nrPDB 198 2e-51 5AMN-A nrPDB 198 2e-51 5O0Y-A nrPDB 198 3e-51 6E4F-A nrPDB 198 3e-51 4XI2-A nrPDB 198 3e-51 5HVK-A nrPDB 198 4e-51 2PSQ-A nrPDB 197 5e-51 5O2B-A nrPDB 197 6e-51 5TUR-A nrPDB 197 6e-51 3BGP-A nrPDB 197 6e-51 2OGV-A nrPDB 197 6e-51 4Y93-A nrPDB 197 7e-51 5O2C-A nrPDB 197 8e-51 2ZMD-A nrPDB 197 9e-51 2HK5-A nrPDB 197 9e-51 5AP3-A nrPDB 196 1e-50 4RC3-A nrPDB 196 1e-50 3BEA-A nrPDB 196 1e-50 5U6B-A nrPDB 195 2e-50 3I81-A nrPDB 195 3e-50 3CJF-A nrPDB 195 3e-50 3KRL-A nrPDB 195 4e-50 5UIU-A nrPDB 194 4e-50 3BBT-B nrPDB 193 6e-50 4Y83-A nrPDB 193 7e-50 5EG3-A nrPDB 193 8e-50 4PWN-A nrPDB 193 8e-50 5FM2-A nrPDB 193 9e-50 4M7I-A nrPDB 193 1e-49 3MY0-A nrPDB 193 1e-49 4R7H-A nrPDB 192 2e-49 3G0E-A nrPDB 192 2e-49 4HZS-A nrPDB 192 2e-49 5TQX-A nrPDB 192 2e-49 3ZBF-A nrPDB 192 2e-49 3QA8-A nrPDB 191 3e-49 3C1X-A nrPDB 191 4e-49 5VD3-A nrPDB 191 4e-49 5TOS-A nrPDB 191 4e-49 5HLW-A nrPDB 191 5e-49 6CTH-A nrPDB 190 5e-49 1U54-B nrPDB 190 6e-49 1U59-A nrPDB 190 6e-49 1AD5-A nrPDB 190 6e-49 4YFF-A nrPDB 190 7e-49 4X7Q-B nrPDB 190 9e-49 5GRN-A nrPDB 189 1e-48 3PP0-A nrPDB 189 1e-48 3LZB-A nrPDB 188 2e-48 2OZO-A nrPDB 188 2e-48 5GNK-A nrPDB 188 3e-48 3PLS-A nrPDB 188 4e-48 3MDY-A nrPDB 187 6e-48 3QUP-A nrPDB 187 7e-48 2X7G-A nrPDB 187 8e-48 4TPT-A nrPDB 187 8e-48 2JD5-A nrPDB 187 8e-48 4WUA-A nrPDB 187 8e-48 6J5U-C nrPDB 187 9e-48 2PMN-X nrPDB 186 1e-47 1PY5-A nrPDB 185 2e-47 2A1A-B nrPDB 185 2e-47 3LLT-A nrPDB 184 5e-47 4NEU-A nrPDB 183 7e-47 5U6C-A nrPDB 183 8e-47 4LRM-A nrPDB 183 1e-46 3UIU-A nrPDB 181 5e-46 4C59-A nrPDB 180 6e-46 4IDT-A nrPDB 180 6e-46 6B2Q-A nrPDB 180 1e-45 4X3F-A nrPDB 180 1e-45 4OW8-A nrPDB 180 1e-45 3SOC-A nrPDB 180 1e-45 3AOX-A nrPDB 180 1e-45 2RIO-A nrPDB 176 1e-44 5WNO-A nrPDB 176 1e-44 5WNL-A nrPDB 175 3e-44 4PL5-B nrPDB 175 3e-44 5LPZ-A nrPDB 174 4e-44 6HV0-A nrPDB 174 5e-44 5E8V-A nrPDB 174 6e-44 5LPV-A nrPDB 173 7e-44 3ZZW-A nrPDB 173 8e-44 3UIM-A nrPDB 172 2e-43 4F0G-A nrPDB 172 2e-43 2QKW-B nrPDB 171 3e-43 4FL3-A nrPDB 171 4e-43 4JLC-A nrPDB 170 7e-43 4EUU-A nrPDB 170 1e-42 4EUT-A nrPDB 168 3e-42 2QLU-A nrPDB 168 4e-42 5C26-A nrPDB 167 5e-42 4G3E-A nrPDB 166 8e-42 2BUJ-A nrPDB 166 1e-41 6O8B-A nrPDB 165 2e-41 5TE0-A nrPDB 165 2e-41 6NT9-A nrPDB 165 3e-41 3G2F-A nrPDB 164 5e-41 2Y4I-B nrPDB 164 7e-41 5XD6-A nrPDB 163 9e-41 3LMG-A nrPDB 163 1e-40 4LQP-A nrPDB 162 2e-40 5IKW-A nrPDB 161 3e-40 6BFN-A nrPDB 159 2e-39 4F9B-A nrPDB 158 3e-39 4M66-A nrPDB 158 5e-39 2H34-A nrPDB 155 3e-38 5AR8-A nrPDB 154 4e-38 5VC6-A nrPDB 154 5e-38 5VDK-A nrPDB 153 1e-37 3QD2-B nrPDB 152 2e-37 5J0A-A nrPDB 151 3e-37 2CHL-A nrPDB 149 2e-36 4MWI-A nrPDB 144 4e-35 4M69-B nrPDB 144 5e-35 4BTF-A nrPDB 144 6e-35 4L00-A nrPDB 143 1e-34 5X1R-A nrPDB 142 2e-34 3SV0-A nrPDB 141 3e-34 2C47-A nrPDB 141 3e-34 2PZI-A nrPDB 141 4e-34 4Y12-A nrPDB 141 5e-34 5FQD-C nrPDB 140 8e-34 2CMW-A nrPDB 138 3e-33 4TN6-A nrPDB 138 3e-33 5L2Q-C nrPDB 137 5e-33 3HNG-A nrPDB 136 9e-33 3VHK-A nrPDB 136 1e-32 3REP-A nrPDB 136 2e-32 4JRN-A nrPDB 133 1e-31 5M07-A nrPDB 133 2e-31 4RT7-A nrPDB 132 2e-31 5X18-A nrPDB 130 7e-31 4XHH-A nrPDB 125 3e-29 4XHL-A nrPDB 123 1e-28 1CSN-A nrPDB 119 2e-27 5OAT-A nrPDB 109 2e-24 6G4J-A nrPDB 101 6e-22 5CLR-A nrPDB 90 2e-18 5UU1-A nrPDB 86 2e-17 2RSV-A nrPDB 86 3e-17 2LAV-A nrPDB 85 5e-17 Sequences not found previously or not previously below threshold: 6DC0-A nrPDB 133 2e-31 5CEK-A nrPDB 133 2e-31 4NT4-A nrPDB 131 3e-31 5USZ-A nrPDB 130 1e-30 4BTK-A nrPDB 123 1e-28 4NFN-A nrPDB 122 2e-28 5C01-A nrPDB 116 1e-26 4WOV-A nrPDB 116 2e-26 4L68-A nrPDB 114 5e-26 5UV4-A nrPDB 106 2e-23 6J6I-B nrPDB 101 3e-22 4I94-A nrPDB 100 1e-21 6EQI-C nrPDB 98 4e-21 4IX6-A nrPDB 76 2e-14 4O1O-A nrPDB 76 2e-14 4CI6-B nrPDB 71 8e-13 4OAU-C nrPDB 69 4e-12 6EAS-A nrPDB 67 1e-11 6EWX-A nrPDB 66 2e-11 5DMZ-A nrPDB 65 4e-11 5GZ9-A nrPDB 63 2e-10 6M7Z-A nrPDB 61 7e-10 6BHC-A nrPDB 61 7e-10 5GZA-A nrPDB 61 7e-10 2JII-A nrPDB 58 4e-09 4AZW-A nrPDB 54 6e-08 4CYJ-A nrPDB 54 1e-07 4AZV-A nrPDB 53 1e-07 3ENH-A nrPDB 53 2e-07 5VE6-A nrPDB 51 8e-07 6G38-A nrPDB 50 1e-06 4BWP-A nrPDB 48 6e-06 3Q60-A nrPDB 47 1e-05 4WWA-A nrPDB 46 2e-05 6R5K-O nrPDB 46 3e-05 4XR7-L nrPDB 45 6e-05 4CZY-B nrPDB 44 1e-04 3DZO-A nrPDB 43 2e-04 3BYV-A nrPDB 43 2e-04 2W1Z-A nrPDB 43 3e-04 1TQM-A nrPDB 42 4e-04 5YK0-A nrPDB 39 0.003 6FAI-l nrPDB 39 0.003 6G18-v nrPDB 36 0.019 6FDN-A nrPDB 35 0.037 6G5I-z nrPDB 33 0.15 6H8S-A nrPDB 33 0.16 4OTP-A nrPDB 33 0.18 6DFL-A nrPDB 32 0.43 >1UA2-A nrPDB Length = 346 Score = 507 bits (1306), Expect = e-144, Method: Composition-based stats. Identities = 346/346 (100%), Positives = 346/346 (100%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL Sbjct: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM Sbjct: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA Sbjct: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM Sbjct: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG Sbjct: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 Query: 301 PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 346 PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF Sbjct: 301 PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 346 >2BPM-A nrPDB Length = 309 Score = 367 bits (942), Expect = e-102, Method: Composition-based stats. Identities = 135/307 (43%), Positives = 197/307 (64%), Gaps = 5/307 (1%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + ++K++ +GEG + VYKAR+K T ++VA+KKI+L +E G+ TA+REI LL Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLL 60 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMTLQGL 125 +EL+HPNI+ LLD ++ + LVF+F+ DL+ + ++L + IK+Y+ LQGL Sbjct: 61 KELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGL 120 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 + H H +LHRDLKP NLL++ G +KLADFGLA++FG P R YTH+VVT WYRAPE+L Sbjct: 121 AFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL 180 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G + Y VD+W++GCI AE++ R PGDS++DQL RIF TLGTP E WP + S+PD Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 240 Query: 246 YV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304 Y +F + + +D L+ + ++P RI+A AL +F + P P Sbjct: 241 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPH 300 Query: 305 CQLPRPN 311 +L RP+ Sbjct: 301 LRLERPH 307 >3NIZ-A nrPDB Length = 311 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 133/292 (45%), Positives = 190/292 (65%), Gaps = 6/292 (2%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++Y+KL+ +GEG + VYKA+D +IVA+K+I+L E GI TA+REI LL+E Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDE---GIPSTAIREISLLKE 75 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L+D + ++LVF+FME DL+ ++ +N L S IK Y+ L+G+ + Sbjct: 76 LHHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHC 135 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 HQH ILHRDLKP NLL++ +G LKLADFGLA++FG P R+YTH+VVT WYRAP++L G++ Sbjct: 136 HQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSK 195 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV- 247 Y VD+W++GCI AE++ P PG +D DQL +IF LGTP +WP + LP + Sbjct: 196 KYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQ 255 Query: 248 -TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 TF+ F P I + +DL+ + F+P RI+A A+ YF + Sbjct: 256 RTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDL 307 >4AU8-A nrPDB Length = 296 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 132/291 (45%), Positives = 189/291 (64%), Gaps = 5/291 (1%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +++YEKL+ +GEG + TV+KA+++ T++IVA+K+++L + +G+ +ALREI LL+E Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRL---DDDDEGVPSSALREICLLKE 61 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L H NI+ L D ++LVF+F + DL+ + L P +K+++ L+GL + Sbjct: 62 LKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H +LHRDLKP NLL++ NG LKLADFGLA++FG P R Y+ +VVT WYR P++LFGA+ Sbjct: 122 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 189 MYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 +Y +DMW+ GCI AEL P PG+ DQL RIF LGTPTEEQWP M LPDY Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 241 Query: 248 TFKSFPG-IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + +P L ++ DL+Q L NP RI+A +AL+ YFS+ Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292 >6GU6-A nrPDB Length = 302 Score = 343 bits (881), Expect = 6e-95, Method: Composition-based stats. Identities = 128/294 (43%), Positives = 181/294 (61%), Gaps = 6/294 (2%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + Y K++ +GEG + VYK R K T Q+VA+KKI+L E G+ TA+REI LL+ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIREISLLK 61 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKD--NSLVLTPSHIKAYMLMTLQGL 125 EL HPNI+ L D S + L+F+F+ DL+ + + S +K+Y+ LQG+ Sbjct: 62 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 121 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 + H +LHRDLKP NLL+D+ G +KLADFGLA++FG P R YTH+VVT WYR+PE+L Sbjct: 122 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 181 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G+ Y VD+W++G I AEL + P GDS++DQL RIF LGTP E WP++ SL D Sbjct: 182 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 241 Query: 246 YV-TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 Y TF + L ++ LDL+ + +++P RI+ AL YF++ Sbjct: 242 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >1V0B-A nrPDB Length = 288 Score = 339 bits (869), Expect = 1e-93, Method: Composition-based stats. Identities = 121/290 (41%), Positives = 174/290 (60%), Gaps = 5/290 (1%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++Y L+ +GEG + VYKA++ N + A+KKI+L E GI T +REI +L+E Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDE---GIPSTTIREISILKE 56 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L H NI+ L D K + LVF+ ++ DL+ ++ L K+++L L G+ Y Sbjct: 57 LKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H +LHRDLKP NLL++ G LK+ADFGLA++FG P R YTH+VVT WYRAP++L G++ Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV- 247 Y +D+W+VGCI AE++ P PG S+ DQL RIF LGTP + WP++ LP Y Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 F + +P + +DL+ + +P RITA QAL+ YF Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4KRC-A nrPDB Length = 317 Score = 338 bits (866), Expect = 3e-93, Method: Composition-based stats. Identities = 120/305 (39%), Positives = 182/305 (59%), Gaps = 15/305 (4%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 S + ++++L+ LG G +ATVYK +K T VA+K++KL ++++G TA+REI L Sbjct: 1 MSSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL----DSEEGTPSTAIREISL 56 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDN-----SLVLTPSHIKAYMLM 120 ++EL H NI+ L D ++ ++LVF+FM+ DL+ + L + +K + Sbjct: 57 MKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQ 116 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 LQGL + H++ ILHRDLKP NLL+++ G LKL DFGLA++FG P ++ +VVT WYRA Sbjct: 117 LLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRA 176 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 P++L G+R Y +D+W+ GCILAE++ P PG +D +QL IF+ +GTP E WP + Sbjct: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236 Query: 241 CSLPDYV-TFKSFPGIPLH-----HIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 LP Y + P L H +L+D + GL NP R++A QAL + Sbjct: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296 Query: 295 FSNRP 299 F+ Sbjct: 297 FAEYY 301 >5EFQ-A nrPDB Length = 347 Score = 334 bits (858), Expect = 2e-92, Method: Composition-based stats. Identities = 118/343 (34%), Positives = 190/343 (55%), Gaps = 23/343 (6%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 K +++ + +GEG + VYKARDK+T ++VA+KK++L + K+G TA+REIK+ Sbjct: 7 KRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN---EKEGFPITAIREIKI 63 Query: 66 LQELSHPNIIGLLDAFGHKSN----------ISLVFDFMETDLEVIIKDNSLVLTPSHIK 115 L++L+H +II + + K + LVF++M+ DL +++ + +HIK Sbjct: 64 LRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIK 123 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS-PNRAYTHQVV 174 ++M ++GL+Y H+ LHRD+K +N+LL+ G +KLADFGLA+ + S +R YT++V+ Sbjct: 124 SFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 T WYR PELL G Y +D+W+ GCIL EL + P + +L QL I G+P Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCP 243 Query: 235 EQWPDMCSLPDYVTFKSFPGI--PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 WPD+ LP + T K L F LDL + +P R TA QAL+ Sbjct: 244 AVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQC 303 Query: 293 KYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEAL 335 ++ + ++P P+ P L + + + KR+R + + Sbjct: 304 EFLRD----VEPSKMPPPDLP---LWQDCHELWSKKRRRQKQM 339 >4NST-A nrPDB Length = 351 Score = 325 bits (833), Expect = 2e-89, Method: Composition-based stats. Identities = 114/342 (33%), Positives = 186/342 (54%), Gaps = 23/342 (6%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 K +++ + +GEG + VYKA+DK+T ++VA+KK++L + K+G TA+REIK+ Sbjct: 9 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN---EKEGFPITAIREIKI 65 Query: 66 LQELSHPNIIGLLDAFGHKSN----------ISLVFDFMETDLEVIIKDNSLVLTPSHIK 115 L++L H +++ + + K + LVF++M+ DL +++ + + HIK Sbjct: 66 LRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIK 125 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS-PNRAYTHQVV 174 ++M ++GLEY H+ LHRD+K +N+LL+ +G +KLADFGLA+ + S +R YT++V+ Sbjct: 126 SFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 T WYR PELL G Y +D+W+ GCIL EL + P + +L QL I G+P Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCP 245 Query: 235 EQWPDMCSLPDYVTFKSFPGI--PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 WPD+ LP + T K L FS LDL+ + +P R TA Q L+ Sbjct: 246 AVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 305 Query: 293 KYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEA 334 + + ++ P+ P + + + KR+R Sbjct: 306 DFLKD----VELSKMAPPDLPH---WQDCHELWSKKRRRQRQ 340 >4QTB-A nrPDB Length = 380 Score = 316 bits (810), Expect = 9e-87, Method: Composition-based stats. Identities = 114/342 (33%), Positives = 165/342 (48%), Gaps = 18/342 (5%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY +L ++GEG + V A D VAIKKI + LREI++L Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPF----EHQTYCQRTLREIQILLRFR 97 Query: 71 HPNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 H N+IG+ D ++ +V D METDL ++K S L+ HI ++ L+GL Sbjct: 98 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLK--SQQLSNDHICYFLYQILRGL 155 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA---YTHQVVTRWYRAPE 182 +Y+H +LHRDLKP+NLL++ LK+ DFGLA+ + T V TRWYRAPE Sbjct: 156 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 215 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ ++ Y +D+W+VGCILAE+L P PG LDQL I LG+P++E + + Sbjct: 216 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 275 Query: 243 LPDYVTFKSFPGI---PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 + +S P +F + LDL+ + FNP RIT +AL Y Sbjct: 276 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 335 Query: 300 GPTPGCQLPRPNCPVETLKEQ-SNPALAIKRKRTEALEQGGL 340 PT P L + + + T + G L Sbjct: 336 DPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVL 377 >2F9G-A nrPDB Length = 353 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 112/345 (32%), Positives = 168/345 (48%), Gaps = 26/345 (7%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + + ++ LGEG + V A K T +IVAIKKI+ K LREIK+L Sbjct: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFD----KPLFALRTLREIKIL 63 Query: 67 QELSHPNIIGLL-----DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 + H NII + D+F + + + ++ + M+TDL +I + +L+ HI+ ++ T Sbjct: 64 KHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS--TQMLSDDHIQYFIYQT 121 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS----------PNRAYTH 171 L+ ++ LH ++HRDLKP+NLL++ N LK+ DFGLA+ T Sbjct: 122 LRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTE 181 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 V TRWYRAPE++ + Y +D+W+ GCILAEL LR P PG QL IF +GT Sbjct: 182 YVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGT 241 Query: 232 PTEEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287 P + P + +P PL +F +DL+Q + +F+P RITA Sbjct: 242 PHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK 301 Query: 288 QALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRT 332 +AL+ Y P + P P + AL K + Sbjct: 302 EALEHPYLQTYHDPNDEPEG-EPIPPSFFEFDHYKEALTTKDLKK 345 >4EWQ-A nrPDB Length = 383 Score = 315 bits (807), Expect = 2e-86, Method: Composition-based stats. Identities = 108/328 (32%), Positives = 164/328 (50%), Gaps = 17/328 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +RY+ L +G G + +V A D T VA+KK+ +S + RE++LL+ Sbjct: 44 PERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH---AKRTYRELRLLKH 100 Query: 69 LSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 + H N+IGLLD F +++ LV M DL I+K LT H++ + L Sbjct: 101 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQIL 158 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +GL+Y+H I+HRDLKP+NL ++E+ LK+ DFGLA+ + T V TRWYRAPE Sbjct: 159 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAPE 215 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ Y VD+W+VGCI+AELL PG +DQL I +GTP E + S Sbjct: 216 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISS 275 Query: 243 LPDYVTFKSF---PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 +S P + ++F A +DL++ + + + RITA QAL YF+ Sbjct: 276 ESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYH 335 Query: 300 GPTPGCQLPRPNCPVETLKEQSNPALAI 327 P + E+ + ++ Sbjct: 336 DPDDEPVADPYDQSFESRDLLIDEWKSL 363 >1CM8-A nrPDB Length = 367 Score = 315 bits (807), Expect = 2e-86, Method: Composition-based stats. Identities = 107/342 (31%), Positives = 164/342 (47%), Gaps = 20/342 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y L +G G + V A D T VAIKK+ +R + + A RE++LL+ + H Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL---YRPFQSELFAKRAYRELRLLKHMRH 83 Query: 72 PNIIGLLDAFGHK------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 N+IGLLD F ++ LV FM TDL ++K L I+ + L+GL Sbjct: 84 ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK--LGEDRIQFLVYQMLKGL 141 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y+H I+HRDLKP NL ++E+ LK+ DFGLA+ + T VVTRWYRAPE++ Sbjct: 142 RYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---ADSEMTGYVVTRWYRAPEVIL 198 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Y VD+W+VGCI+AE++ G LDQL I + GTP E + S Sbjct: 199 NWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEA 258 Query: 246 YVTFKSFPG---IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 K P I + A ++L++ + + + R+TA +AL YF + Sbjct: 259 KNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHDTE 318 Query: 303 PGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKL 344 Q+ + + + + + + K + + P++L Sbjct: 319 DEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKP---PRQL 357 >5NGU-A nrPDB Length = 381 Score = 314 bits (806), Expect = 2e-86, Method: Composition-based stats. Identities = 118/340 (34%), Positives = 163/340 (47%), Gaps = 18/340 (5%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY L ++GEG + V A D VAIKKI + LREIK+L Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPF----EHQTYCQRTLREIKILLRFR 98 Query: 71 HPNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 H NIIG+ D ++ +V D METDL ++K L+ HI ++ L+GL Sbjct: 99 HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGL 156 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA---YTHQVVTRWYRAPE 182 +Y+H +LHRDLKP+NLLL+ LK+ DFGLA+ + T V TRWYRAPE Sbjct: 157 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPE 216 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ ++ Y +D+W+VGCILAE+L P PG LDQL I LG+P++E + + Sbjct: 217 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 276 Query: 243 LPDYVTFKSFPGI---PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 L S P P + +F A LDL+ + FNP RI QAL Y Sbjct: 277 LKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYY 336 Query: 300 GPTPGCQLPRPNCPVETLKEQSNPAL-AIKRKRTEALEQG 338 P+ P L + L + + T + G Sbjct: 337 DPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPG 376 >5Z33-A nrPDB Length = 425 Score = 314 bits (806), Expect = 3e-86, Method: Composition-based stats. Identities = 114/312 (36%), Positives = 160/312 (51%), Gaps = 16/312 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +RY LG+G + V A + T++ VAIKK+ +K + + ALREIKLLQ Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV---TNVFSKKILAKRALREIKLLQHF 87 Query: 70 S-HPNIIGLLDAFGHK----SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 H NI L D + + L + ME DL II+ LT +H ++++ L G Sbjct: 88 RGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS-GQPLTDAHFQSFIYQILCG 146 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA----YTHQVVTRWYRA 180 L+Y+H +LHRDLKP NLL++ + LK+ DFGLA+ F T V TRWYRA Sbjct: 147 LKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRA 206 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ + Y +D+W+VGCILAELL PF G +DQL +I LGTP EE + Sbjct: 207 PEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRI 266 Query: 241 CSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 S ++ P P +F A D LDL+ + F+P +RI+ QAL+ Y Sbjct: 267 GSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHI 326 Query: 298 RPGPTPGCQLPR 309 + P Sbjct: 327 WHDASDEPDCPT 338 >3GC9-A nrPDB Length = 370 Score = 311 bits (797), Expect = 3e-85, Method: Composition-based stats. Identities = 112/328 (34%), Positives = 166/328 (50%), Gaps = 17/328 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +R + L +G G + +V A D Q VA+KK+ +S R RE++LL+ Sbjct: 27 PQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIH---ARRTYRELRLLKH 83 Query: 69 LSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L H N+IGLLD F S + LV M DL I+K S L+ H++ + L Sbjct: 84 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK--SQALSDEHVQFLVYQLL 141 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +GL+Y+H I+HRDLKP+N+ ++E+ L++ DFGLA+ + T V TRWYRAPE Sbjct: 142 RGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQ---ADEEMTGYVATRWYRAPE 198 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ Y VD+W+VGCI+AELL PG +DQL RI E +GTP+ E + S Sbjct: 199 IMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISS 258 Query: 243 LPDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 +S P +P L IF A +DL+ + + + R++A +AL YFS Sbjct: 259 EHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYH 318 Query: 300 GPTPGCQLPRPNCPVETLKEQSNPALAI 327 P + + VE + + Sbjct: 319 DPEDEPEAEPYDESVEAKERTLEEWKEL 346 >3OHT-A nrPDB Length = 389 Score = 311 bits (796), Expect = 4e-85, Method: Composition-based stats. Identities = 105/325 (32%), Positives = 164/325 (50%), Gaps = 17/325 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +RY+ L +G G + +V + D + +A+KK+ +S + RE++LL+ Sbjct: 50 PERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIH---AKRTYRELRLLKH 106 Query: 69 LSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 + H N+IGLLD F +++ LV M DL I+K LT H++ + L Sbjct: 107 MKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVK--CQKLTDDHVQFLIYQIL 164 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +GL+Y+H I+HRDLKP+NL ++E+ LK+ DFGLA+ + T V TRWYRAPE Sbjct: 165 RGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR---HTDDEMTGYVATRWYRAPE 221 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ Y + VD+W+VGCI+AELL PG ++QL +I GTP M S Sbjct: 222 IMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPS 281 Query: 243 LPDYVTFKSFPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 S P +P +F A +DL++ + + + RITA++AL YFS Sbjct: 282 HEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYH 341 Query: 300 GPTPGCQLPRPNCPVETLKEQSNPA 324 P + + E+ + + Sbjct: 342 DPDDEPESEPYDQSFESRQLEIEEW 366 >4MYG-A nrPDB Length = 372 Score = 310 bits (795), Expect = 6e-85, Method: Composition-based stats. Identities = 106/324 (32%), Positives = 160/324 (49%), Gaps = 23/324 (7%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G + +V A DK + + VAIKK+ +SE + A RE+ LL+ + H N+IGL Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEI---FAKRAYRELLLLKHMQHENVIGL 107 Query: 78 LDAFGHKSNI------SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 LD F S++ LV FM+TDL+ I+ + + I+ + L+GL+Y+H Sbjct: 108 LDVFTPASSLRNFYDFYLVMPFMQTDLQKIM---GMEFSEEKIQYLVYQMLKGLKYIHSA 164 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 ++HRDLKP NL ++E+ LK+ DFGLA+ + T VVTRWYRAPE++ Y Sbjct: 165 GVVHRDLKPGNLAVNEDCELKILDFGLAR---HADAEMTGYVVTRWYRAPEVILSWMHYN 221 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 VD+W+VGCI+AE+L G LDQLT+I + G P E + +S Sbjct: 222 QTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQS 281 Query: 252 FPGIP---LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 P P +F A DL++ + + R+TA QAL +F P + Sbjct: 282 LPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEETEAQ 341 Query: 309 RPNCPVETLKEQSNPALAIKRKRT 332 +P + L + + Sbjct: 342 QPFD-----DSLEHEKLTVDEWKQ 360 >5JN2-A nrPDB Length = 525 Score = 310 bits (794), Expect = 7e-85, Method: Composition-based stats. Identities = 85/322 (26%), Positives = 139/322 (43%), Gaps = 33/322 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ LG+G F V +DK T Q A+K I + D + LRE++LL++ Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD--KESLLREVQLLKQ 123 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L + F K LV + + + + L G+ Y+ Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 183 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H++ I+HRDLKP NLLL ++ +++ DFGL+ F ++ ++ T +Y APE+L Sbjct: 184 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPEVLH 242 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G Y D+W+ G IL LL P G ++ D L ++ + T QW Sbjct: 243 GT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWK------- 293 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGC 305 + DLI+ + + P RI+A AL ++ Sbjct: 294 -----------------KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISV 336 Query: 306 QLPRPNCPVETLKE-QSNPALA 326 +P + + +++ Q LA Sbjct: 337 DVPSLDNAILNIRQFQGTQKLA 358 >1G3N-A nrPDB Length = 326 Score = 310 bits (794), Expect = 7e-85, Method: Composition-based stats. Identities = 116/318 (36%), Positives = 170/318 (53%), Gaps = 18/318 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++YE + +GEG + V+KARD KN + VA+K++++ E G+ + +RE+ +L+ Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE---GMPLSTIREVAVLRH 67 Query: 69 LS---HPNIIGLLDAFG-----HKSNISLVFDFMETDLEVIIKDNSLVLTP-SHIKAYML 119 L HPN++ L D ++ ++LVF+ ++ DL + P IK M Sbjct: 68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMF 127 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L+GL++LH H ++HRDLKP N+L+ +G +KLADFGLA+ S A T VVT WYR Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAR-IYSFQMALTSVVVTLWYR 186 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L + Y VD+W+VGCI AE+ R P G SD+DQL +I + +G P EE WP Sbjct: 187 APEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 +LP F S P+ + + DL+ FNP RI+A AL YF + Sbjct: 246 DVALPRQA-FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 Query: 300 GPTPGCQ--LPRPNCPVE 315 LP E Sbjct: 305 RCKENLDSHLPPSQNTSE 322 >6DTL-A nrPDB Length = 364 Score = 310 bits (794), Expect = 7e-85, Method: Composition-based stats. Identities = 112/346 (32%), Positives = 178/346 (51%), Gaps = 19/346 (5%) Query: 3 LDVKSRAKRYEK-LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 ++ +Y+ + +G+G + V A + TN+ VAIKKI ++ + LR Sbjct: 22 GNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKID---AKRTLR 78 Query: 62 EIKLLQELSHPNIIGLLDAFGHK-----SNISLVFDFMETDLEVIIKDNSLVLTPSHIKA 116 EIKLL+ + H NI+ + D +++ + ++ M+TDL II+ N L+ H + Sbjct: 79 EIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN-QALSEEHCQY 137 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 ++ L+GL+Y+H +LHRDLKP+NLLL+ N LK+ DFGLA+ S + T VVTR Sbjct: 138 FLYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTR 196 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 WYRAPELL + Y +D+W+VGCI EL+ R P PG + QL + E +GTP+EE+ Sbjct: 197 WYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEE 256 Query: 237 WPDMCSLPDYVTFK--SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 + + +P + F +DLI+ + F+P RIT AL Y Sbjct: 257 LEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPY 316 Query: 295 FSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340 ++ + P C + + N AL+ + + E + + L Sbjct: 317 LNSLHDIS-----DEPECTIPFNFDFENHALS-EEQMKELIYREAL 356 >3GC0-A nrPDB Length = 329 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 129/303 (42%), Positives = 184/303 (60%), Gaps = 11/303 (3%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A + RY ++ LGEG + VYKA D TN+ VAIK+I+L H E G+ TA+R Sbjct: 26 AAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEE---GVPGTAIR 82 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E+ LL+EL H NII L H + L+F++ E DL+ + N V + IK+++ Sbjct: 83 EVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNPDV-SMRVIKSFLYQL 141 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD-----ENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 + G+ + H LHRDLKP NLLL E VLK+ DFGLA++FG P R +TH+++T Sbjct: 142 INGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITL 201 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 WYR PE+L G+R Y VD+W++ CI AE+L++ P PGDS++DQL +IFE LG P + Sbjct: 202 WYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTT 261 Query: 237 WPDMCSLPDYV-TFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKY 294 WP + +LPD+ +F F G L + A D+ LDL+ + +P RI+A AL+ Y Sbjct: 262 WPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPY 321 Query: 295 FSN 297 FS+ Sbjct: 322 FSH 324 >5G6V-A nrPDB Length = 324 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 117/289 (40%), Positives = 174/289 (60%), Gaps = 6/289 (2%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + Y KLD LGEG +ATVYK + K T+ +VA+K+I+L H ++G TA+RE+ LL++ Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH----EEGAPCTAIREVSLLKD 56 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L H NI+ L D + +++LVF++++ DL+ + D ++ ++K ++ L+GL Y Sbjct: 57 LKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 116 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H+ +LHRDLKP NLL++E G LKLADFGLA++ P + Y ++VVT WYR P++L G+ Sbjct: 117 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 Y +DMW VGCI E+ P PG + +QL IF LGTPTEE WP + S ++ T Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 236 Query: 249 --FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + + L D DL+ L F RI+A A+K +F Sbjct: 237 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >4AGU-A nrPDB Length = 311 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 115/314 (36%), Positives = 169/314 (53%), Gaps = 10/314 (3%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 ++YEK+ +GEG + V+K R+++T QIVAIKK SE I + ALREI++L+ Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF---LESEDDPVIKKIALREIRMLK 57 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 +L HPN++ LL+ F K + LVF++ + + + + +K+ TLQ + + Sbjct: 58 QLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNF 117 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 H+H +HRD+KP N+L+ ++ V+KL DFG A+ P+ Y +V TRWYR+PELL G Sbjct: 118 CHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGD 177 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 YG VD+WA+GC+ AELL VP PG SD+DQL I +TLG + + S Y Sbjct: 178 TQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIP-RHQQVFSTNQYF 236 Query: 248 TFKSFPGI----PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + P PL F L L++G +P R+T Q L YF N Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 Query: 304 GCQLPRPNCPVETL 317 + + P E L Sbjct: 297 LAK--EHDKPAENL 308 >4BBM-A nrPDB Length = 331 Score = 307 bits (787), Expect = 5e-84, Method: Composition-based stats. Identities = 100/292 (34%), Positives = 156/292 (53%), Gaps = 6/292 (2%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 ++YE L +GEG + V K R+K+T +IVAIKK S+ + + A+REIKLL+ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF---LESDDDKMVKKIAMREIKLLK 79 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 +L H N++ LL+ K LVF+F++ + ++ L ++ Y+ + G+ + Sbjct: 80 QLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGF 139 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 H H I+HRD+KP N+L+ ++GV+KL DFG A++ +P Y +V TRWYRAPELL G Sbjct: 140 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGD 199 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 YG VD+WA+GC++ E+ + P PGDSD+DQL I LG P + Sbjct: 200 VKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA 259 Query: 248 TFKS---FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + PL + + ++DL + +P R + L +F Sbjct: 260 GVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4IC8-A nrPDB Length = 442 Score = 306 bits (783), Expect = 1e-83, Method: Composition-based stats. Identities = 108/315 (34%), Positives = 158/315 (50%), Gaps = 19/315 (6%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 YE ++ +G G + V AR + T Q VAIKKI + LRE+K+L+ Sbjct: 54 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN---AKRTLRELKILKH 110 Query: 69 LSHPNIIGLLDA------FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 H NII + D +G ++ +V D ME+DL II S LT H++ ++ L Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHS-SQPLTLEHVRYFLYQLL 169 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF----GSPNRAYTHQVVTRWY 178 +GL+Y+H ++HRDLKP+NLL++EN LK+ DFG+A+ T V TRWY Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 RAPEL+ Y +D+W+VGCI E+L R PG + + QL I LGTP+ Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 289 Query: 239 DMCSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + + +S P +P ++ A L L+ + F P ARI+A AL+ + Sbjct: 290 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 349 Query: 296 SNRPGP--TPGCQLP 308 + P P C P Sbjct: 350 AKYHDPDDEPDCAPP 364 >3NCG-A nrPDB Length = 486 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 92/322 (28%), Positives = 140/322 (43%), Gaps = 34/322 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + A+RY + LG+G F V K +D+ T Q A+K I AK+ T LRE++LL Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKAS---AKNKDTSTILREVELL 75 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 ++L HPNI+ L + S+ +V + + + G+ Sbjct: 76 KKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 127 YLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Y+H+H I+HRDLKP N+LL +++ +K+ DFGL+ F N ++ T +Y APE+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ-NTKMKDRIGTAYYIAPEV 194 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 L G Y D+W+ G IL LL P G ++ D L R+ QW Sbjct: 195 LRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQW------ 246 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 DD DLI+ + F+P RITATQ L+ + TP Sbjct: 247 ------------------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETP 288 Query: 304 G-CQLPRPNCPVETLKEQSNPA 324 LP + +++ Sbjct: 289 TISDLPSLESAMTNIRQFQAEK 310 >4QNY-A nrPDB Length = 354 Score = 304 bits (778), Expect = 5e-83, Method: Composition-based stats. Identities = 100/302 (33%), Positives = 154/302 (50%), Gaps = 12/302 (3%) Query: 10 KRYEKLDFLGEGQFATVYKARD-KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 RY +G G + V +ARD K+ N++VA+K++ E + + LREIKLL Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEV--ILAKRILREIKLLAH 77 Query: 69 LSHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + NIIGL + + + +V D METDL+ +++ LT +HI+ ++ L+ Sbjct: 78 FNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRS-GQELTEAHIQFFIYQALR 136 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 L +H ++HRD+ P N+L++ N LK+ DFGLAK T V RWYRAPEL Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + + Y +D+W +GCIL ELL P G ++QL +I + +GTP+EE + S Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 244 PDYVTFKS---FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 K P + A + LDL++ + +FNP RIT QA++ + Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 Query: 301 PT 302 Sbjct: 317 DA 318 >1JNK-A nrPDB Length = 423 Score = 302 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 101/343 (29%), Positives = 170/343 (49%), Gaps = 29/343 (8%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + KRY+ L +G G V A D ++ VAIKK+ +++ + A RE+ L+ Sbjct: 59 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH---AKRAYRELVLM 115 Query: 67 QELSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 + ++H NII LL+ F ++ LV + M+ +L +I+ + L + + Sbjct: 116 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQ 172 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G + T VVTR+YRA Sbjct: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRA 231 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + Sbjct: 232 PEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 290 Query: 241 C-SLPDYVTFKS------FPGIPLHHIFSAAGD-------DLLDLIQGLFLFNPCARITA 286 ++ +YV + FP + +F A + DL+ + + +P RI+ Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350 Query: 287 TQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 AL+ Y + P + P P + L E+ + K Sbjct: 351 DDALQHPYINVWYDPAE-VEAPPPQIYDKQLDEREHTIEEWKE 392 >4ZSG-A nrPDB Length = 347 Score = 302 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 106/315 (33%), Positives = 156/315 (49%), Gaps = 17/315 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 YE ++ +G G + V AR + T Q VAIKKI + LRE+K+L+ Sbjct: 6 GDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTN---AKRTLRELKILKH 62 Query: 69 LSHPNIIGLLDA------FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 H NII + D +G ++ +V D ME+DL II S LT H++ ++ L Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHS-SQPLTLEHVRYFLYQLL 121 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF----GSPNRAYTHQVVTRWY 178 +GL+Y+H ++HRDLKP+NLL++EN LK+ DFG+A+ T V TRWY Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 RAPEL+ Y +D+W+VGCI E+L R PG + + QL I LGTP+ Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 241 Query: 239 DMCSLPDYVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + + +S P +P ++ A L L+ + F P ARI+A AL+ + Sbjct: 242 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 301 Query: 296 SNRPGPTPGCQLPRP 310 + P P Sbjct: 302 AKYHDPDDEPDCAPP 316 >3MIA-A nrPDB Length = 351 Score = 301 bits (772), Expect = 2e-82, Method: Composition-based stats. Identities = 123/309 (39%), Positives = 173/309 (55%), Gaps = 19/309 (6%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +YEKL +G+G F V+KAR + T Q VA+KK+ K+G TALREIK+LQ L Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKV---LMENEKEGFPITALREIKILQLL 73 Query: 70 SHPNIIGLLDAFGHK--------SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 H N++ L++ K +I LVFDF E DL ++ + + T S IK M M Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQML 133 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF----GSPNRAYTHQVVTRW 177 L GL Y+H++ ILHRD+K N+L+ +GVLKLADFGLA++F S YT++VVT W Sbjct: 134 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLW 193 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 YR PELL G R YG +D+W GCI+AE+ R P + G+++ QL I + G+ T E W Sbjct: 194 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVW 253 Query: 238 PDMCSLPDYVTFKSFPG----IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 P++ + Y + G + LDLI L + +P RI + AL Sbjct: 254 PNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHD 313 Query: 294 YFSNRPGPT 302 +F + P P+ Sbjct: 314 FFWSDPMPS 322 >3OZ6-A nrPDB Length = 388 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 113/346 (32%), Positives = 174/346 (50%), Gaps = 50/346 (14%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + ++YE + LG+G + V+K+ D+ T ++VA+KKI ++ + REI + Sbjct: 5 RHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQN---STDAQRTFREIMI 61 Query: 66 LQELS-HPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L ELS H NI+ LL+ + ++ LVFD+METDL +I+ N +L P H + + + Sbjct: 62 LTELSGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRAN--ILEPVHKQYVVYQLI 119 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-------------------- 162 + ++YLH +LHRD+KP+N+LL+ +K+ADFGL++SF Sbjct: 120 KVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTEN 179 Query: 163 -GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 T V TRWYRAPE+L G+ Y G+DMW++GCIL E+L P PG S ++Q Sbjct: 180 FDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQ 239 Query: 222 LTRIFETLGTPTEEQWPDMC---------SLPDYVTFKSFPGIPLHHIFSA--------- 263 L RI + P+ E + SL + V + + + Sbjct: 240 LERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKA 299 Query: 264 -AGDDLLDLIQGLFLFNPCARITATQALKMKYFS--NRPGPTPGCQ 306 ++ LDL+ L FNP RI+A ALK + S + P P C Sbjct: 300 DCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCD 345 >2XS0-A nrPDB Length = 386 Score = 300 bits (769), Expect = 6e-82, Method: Composition-based stats. Identities = 96/343 (27%), Positives = 162/343 (47%), Gaps = 29/343 (8%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + KRY+ L +G G V A D + VAIKK+ +++ + A RE+ L+ Sbjct: 23 TVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTH---AKRAYRELVLM 79 Query: 67 QELSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 + ++H NIIGLL+ F ++ +V + M+ +L +I+ + L + + Sbjct: 80 KCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ---MELDHERMSYLLYQ 136 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G + VVTR+YRA Sbjct: 137 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMVPFVVTRYYRA 195 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + Sbjct: 196 PEVILGM-GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 254 Query: 241 CSLPD--YVTFKSFPGIPLHHIFSAA------------GDDLLDLIQGLFLFNPCARITA 286 + G +F DL+ + + + RI+ Sbjct: 255 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 314 Query: 287 TQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 +AL+ Y + P+ + P P P + L E+ + K Sbjct: 315 DEALQHPYINVWYDPSE-AEAPPPKIPDKQLDEREHTIEEWKE 356 >3LIJ-A nrPDB Length = 494 Score = 300 bits (768), Expect = 7e-82, Method: Composition-based stats. Identities = 88/319 (27%), Positives = 145/319 (45%), Gaps = 34/319 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++ Y+++ LG G + V RDK T+ AIK I+ S + N L E+ +L+ Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSS---NSKLLEEVAVLKL 92 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L D F K N LV + + + + + L G+ YL Sbjct: 93 LDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYL 152 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H+H I+HRDLKP NLLL +++ ++K+ DFGL+ F + ++ T +Y APE+L Sbjct: 153 HKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVF-ENQKKMKERLGTAYYIAPEVL- 210 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + Y D+W++G IL LL P G +D + L ++ + T +W ++ Sbjct: 211 -RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEWKNV----- 264 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR-PGPTPG 304 + DLI+ + F+ RI+A QAL+ + G Sbjct: 265 -------------------SEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESG 305 Query: 305 CQLPRPNCPVETLKEQSNP 323 +LP +E +++ N Sbjct: 306 IELPSLANAIENMRKFQNS 324 >3E7O-A nrPDB Length = 360 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 102/349 (29%), Positives = 167/349 (47%), Gaps = 29/349 (8%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 +A + KRY++L +G G V A D VA+KK+ +++ + A Sbjct: 13 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTH---AKRAY 69 Query: 61 REIKLLQELSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHI 114 RE+ LL+ ++H NII LL+ F ++ LV + M+ +L +I + L + Sbjct: 70 RELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH---MELDHERM 126 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV 174 + L G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ S N T VV Sbjct: 127 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-ASTNFMMTPYVV 185 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 TR+YRAPE++ G Y VD+W+VGCI+ EL+ G +DQ ++ E LGTP+ Sbjct: 186 TRYYRAPEVILGM-GYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSA 244 Query: 235 EQWPDMCSLPDYV--TFKSFPGIPLH-----HIFSAAGD-------DLLDLIQGLFLFNP 280 E + ++PGI IF + + DL+ + + +P Sbjct: 245 EFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 304 Query: 281 CARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 RI+ +AL+ Y + P + P P L+E+ + K Sbjct: 305 DKRISVDEALRHPYITVWYDPAE-AEAPPPQIYDAQLEEREHAIEEWKE 352 >2W96-B nrPDB Length = 306 Score = 297 bits (762), Expect = 4e-81, Method: Composition-based stats. Identities = 112/306 (36%), Positives = 163/306 (53%), Gaps = 15/306 (4%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 RYE + +G G + TVYKARD ++ VA+K +++ + E G+ + +RE+ LL Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEE---GLPISTVREVALL 57 Query: 67 QELS---HPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLV-LTPSHIKAY 117 + L HPN++ L+D ++LVF+ ++ DL + L IK Sbjct: 58 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 117 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 M L+GL++LH + I+HRDLKP N+L+ G +KLADFGLA+ S A VVT W Sbjct: 118 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALDPVVVTLW 176 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 YRAPE+L + Y VDMW+VGCI AE+ R P G+S+ DQL +IF+ +G P E+ W Sbjct: 177 YRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 235 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 P SLP F P+ + + L+ + FNP RI+A +AL+ Y Sbjct: 236 PRDVSLPR-GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 Query: 298 RPGPTP 303 G Sbjct: 295 DEGNPE 300 >5AWM-A nrPDB Length = 394 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 101/341 (29%), Positives = 161/341 (47%), Gaps = 30/341 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 RY L +G G V A D T Q VAIKK+ ++ + A RE KL++ + Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTH---AKRAYREFKLMKLV 100 Query: 70 SHPNIIGLLDAFGHKSNI------SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 +H NIIGLL+AF + N+ LV + M+ +L +I+ + L + + L Sbjct: 101 NHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYLLYQMLC 157 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G+ T VVTR+YRAPE+ Sbjct: 158 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-FMMTPYVVTRYYRAPEV 216 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G Y VD+W+VGCI+ E++ PG +DQ +I E LGTP+ + Sbjct: 217 ILGM-GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPT 275 Query: 244 PDYV--TFKSFPGIPLHHIFSAA-------------GDDLLDLIQGLFLFNPCARITATQ 288 + G +F D +L+ + + +P RI+ + Sbjct: 276 VRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 335 Query: 289 ALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 ALK +Y + P P ++ E+ + K Sbjct: 336 ALKHEYINVWYDAEE-VDAPAPEPYDHSVDEREHTVEQWKE 375 >4BGQ-A nrPDB Length = 304 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 110/301 (36%), Positives = 166/301 (55%), Gaps = 9/301 (2%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 ++ + ++E L +GEG + V K R K T++IVAIKK K SE + + T LRE+ Sbjct: 6 NIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKD---SEENEEVKETTLREL 62 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 K+L+ L NI+ L +AF + + LVF+++E ++ ++++ + P +K+Y+ ++ Sbjct: 63 KMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIK 122 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA-YTHQVVTRWYRAPE 182 + + H++ I+HRD+KP NLL+ N VLKL DFG A++ N A Y +V TRWYR+PE Sbjct: 123 AIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPE 182 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 LL GA YG VDMW+VGCIL EL P PG+S++DQL I + LG EQ S Sbjct: 183 LLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 241 Query: 243 LPDYVTFK----SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 P + + + P LLDL++ L +P R Q L F + Sbjct: 242 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 301 Query: 299 P 299 Sbjct: 302 R 302 >4O2Z-A nrPDB Length = 377 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 96/331 (29%), Positives = 150/331 (45%), Gaps = 17/331 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +Y L LG G + D +T + V+IKK + R + LREI +++ Sbjct: 44 PSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVED---GKRVLREIDMMRF 100 Query: 69 LSHPNIIG-------LLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 H N++ L + ++ +V M+ D+ V+++ VL SH++ ++ Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSR-QVLEESHMQYFVYQI 159 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 L+GL+YLH + HRDLKP NL+ + + LK+ DFGL++S P T V+TRWYR P Sbjct: 160 LRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPP 219 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 ELL Y VD+W+VGCI AE+ R P PG + +DQL I + +G P Sbjct: 220 ELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHRE 279 Query: 242 SLPDYVTFKS-FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 +L IP A + +D + ++ +P R TA L Y ++ Sbjct: 280 ALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 Query: 301 PTPGCQLPRPNCPVETLKEQSNPALAIKRKR 331 P CP L + + + R Sbjct: 340 EE-----DEPTCPCPFLWAHESTPMGVSELR 365 >3ZDU-A nrPDB Length = 325 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 97/294 (32%), Positives = 156/294 (53%), Gaps = 7/294 (2%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + YE L +GEG + TV K + KNT QIVAIK + +N+ A+REIK L+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF----YERPEQSVNKIAMREIKFLK 56 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 + H N++ L++ F K I LVF+F++ + ++ L ++ Y+ L+ ++Y Sbjct: 57 QFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDY 116 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 LH + I+HRD+KP N+L+ ++G+ KL DFG A++ +P Y +V TRWYRAPEL+ Sbjct: 117 LHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY- 246 YG VD+WA+GC++ E+ P+LP SDLD L +I +G + P + Sbjct: 177 TSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 247 --VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 V + + L D++ +P RI+++ L +YF+ Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 >3HZT-A nrPDB Length = 467 Score = 294 bits (753), Expect = 4e-80, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 126/292 (43%), Gaps = 32/292 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+++ LG G + V +DK T AIK IK + + + L E+ +L++ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSN--SGALLDEVAVLKQ 60 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L + F K N LV + + M L G YL Sbjct: 61 LDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYL 120 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H+H I+HRDLKP NLLL + ++K+ DFGL+ F + ++ T +Y APE+L Sbjct: 121 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVL- 178 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + Y D+W+ G IL LL P G +D + L R+ + + W Sbjct: 179 -RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW-------- 229 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + D+ L++ + + P RI+A +AL + Sbjct: 230 ----------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 265 >4MVF-A nrPDB Length = 506 Score = 293 bits (751), Expect = 7e-80, Method: Composition-based stats. Identities = 81/301 (26%), Positives = 130/301 (43%), Gaps = 35/301 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +Y + LG+G + VYK DK TNQ+ AIK+ K +EI+++++L Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN-----RFFQEIEIMKKL 111 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HPNI+ L + + + + I L+ + + T + M + YLH Sbjct: 112 DHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLH 171 Query: 130 QHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I+HRDLKP N L +++ +LK+ DFGL+K+ G T + T +Y AP++L G Sbjct: 172 SLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLG-TGEFTTTKAGTPYYVAPQVLDG 230 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 Y D+W+ G I+ LL P GD+D + L ++ + E W + S Sbjct: 231 --KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISS---- 284 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 D +LI L +NP R T +AL + + + Sbjct: 285 --------------------DAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVE 324 Query: 307 L 307 L Sbjct: 325 L 325 >3MA6-A nrPDB Length = 298 Score = 292 bits (748), Expect = 1e-79, Method: Composition-based stats. Identities = 81/297 (27%), Positives = 129/297 (43%), Gaps = 32/297 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ LG+G F V +DK T Q A+K I + D + LRE++LL++ Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD--KESLLREVQLLKQ 88 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L + F K LV + + + + L G+ Y+ Sbjct: 89 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 148 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H++ I+HRDLKP NLLL ++ +++ DFGL+ F ++ ++ T +Y APE+L Sbjct: 149 HKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF-EASKKMKDKIGTAYYIAPEVLH 207 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G Y D+W+ G IL LL P G ++ D L ++ + T QW Sbjct: 208 GT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWK------- 258 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 + DLI+ + + P RI+A AL ++ Sbjct: 259 -----------------KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 298 >3DXN-A nrPDB Length = 287 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 126/292 (43%), Gaps = 32/292 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+++ LG G + V +DK T AIK IK + + + L E+ +L++ Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSN--SGALLDEVAVLKQ 77 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L + F K N LV + + M L G YL Sbjct: 78 LDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYL 137 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H+H I+HRDLKP NLLL + ++K+ DFGL+ F + ++ T +Y APE+L Sbjct: 138 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVL- 195 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + Y D+W+ G IL LL P G +D + L R+ + + W Sbjct: 196 -RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW-------- 246 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + D+ L++ + + P RI+A +AL + Sbjct: 247 ----------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >4YZB-A nrPDB Length = 491 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 84/322 (26%), Positives = 136/322 (42%), Gaps = 33/322 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RY+ LG+G F V +DK T Q A+K I + D +LL++ Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEV--ELLKK 86 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L + F K LV + + + + L G+ Y+ Sbjct: 87 LDHPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYM 146 Query: 129 HQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H++ I+HRDLKP NLLL+ ++ +++ DFGL+ F S + ++ T +Y APE+L Sbjct: 147 HKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFEST-KKMKDKIGTAYYIAPEVLH 205 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G Y D+W+ G IL LL P G ++ D L ++ + T QW Sbjct: 206 GT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWK------- 256 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGC 305 + DLI+ + + P RI+A AL+ ++ T Sbjct: 257 -----------------KVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSI 299 Query: 306 QLPRPNCPVETLKE-QSNPALA 326 +P + +++ Q LA Sbjct: 300 DVPSLESTILNIRQFQGTQKLA 321 >3DFA-A nrPDB Length = 286 Score = 291 bits (746), Expect = 2e-79, Method: Composition-based stats. Identities = 88/298 (29%), Positives = 132/298 (44%), Gaps = 33/298 (11%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + A+RY + LG+G F V K +D+ T Q A+K I AK+ T LRE++LL Sbjct: 19 TFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKAS---AKNKDTSTILREVELL 75 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 ++L HPNI+ L + S+ +V + + + G+ Sbjct: 76 KKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 127 YLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Y+H+H I+HRDLKP N+LL +++ +K+ DFGL+ F N ++ T +Y APE+ Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ-NTKMKDRIGTAYYIAPEV 194 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 L G Y D+W+ G IL LL P G ++ D L R+ QW Sbjct: 195 LRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQW------ 246 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 DD DLI+ + F+P RITATQ L+ + Sbjct: 247 ------------------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >3PG1-A nrPDB Length = 362 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 104/310 (33%), Positives = 152/310 (49%), Gaps = 17/310 (5%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRS------EAKDGINRTALREIKL 65 Y F+ G + V D + VAIK++ + + + LREI+L Sbjct: 24 YTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 66 LQELSHPNIIGLLDAFGH-----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 L HPNI+GL D F H + LV + M TDL +I D +V++P HI+ +M Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYH 142 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L GL LH+ ++HRDL P N+LL +N + + DF LA+ + + TH V RWYRA Sbjct: 143 ILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLARE-DTADANKTHYVTHRWYRA 201 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ--WP 238 PEL+ + + VDMW+ GC++AE+ R G + +QL +I E +GTP E Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 239 DMCSLPDYV--TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 S DY+ + + P + A LDLI + FNP RI+ QAL+ YF Sbjct: 262 SSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFE 321 Query: 297 NRPGPTPGCQ 306 + P + Sbjct: 322 SLFDPLDLTE 331 >3COM-A nrPDB Length = 314 Score = 284 bits (728), Expect = 3e-77, Method: Composition-based stats. Identities = 85/334 (25%), Positives = 150/334 (44%), Gaps = 47/334 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 K + ++ L+ LGEG + +VYKA K T QIVAIK++ + + + ++EI Sbjct: 24 TKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV-------ESDLQEIIKEIS 76 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 ++Q+ P+++ ++ +++ +V ++ + II+ + LT I + TL+ Sbjct: 77 IMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLK 136 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GLEYLH +HRD+K N+LL+ G KLADFG+A + T ++ APE+ Sbjct: 137 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 196 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y D+W++G E+ P +D+ + IF P P Sbjct: 197 IQEI-GYNCVADIWSLGITAIEMAEGKPPY---ADIHPMRAIFMIPTNP-----PPTFRK 247 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P+ D+ D ++ + +P R TATQ L+ + + G Sbjct: 248 PELW-----------------SDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG--- 287 Query: 304 GCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQ 337 V L++ N A+ +K KR E+ ++ Sbjct: 288 ----------VSILRDLINEAMDVKLKRQESQQR 311 >3FI2-A nrPDB Length = 353 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 95/313 (30%), Positives = 161/313 (51%), Gaps = 28/313 (8%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + KRY+ L +G G V A D ++ VAIKK+ +++ + A RE+ L+ Sbjct: 21 TVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTH---AKRAYRELVLM 77 Query: 67 QELSHPNIIGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 + ++H NII LL+ F ++ LV + M+ +L +I+ + L + + Sbjct: 78 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYLLYQ 134 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L G+++LH I+HRDLKP+N+++ + LK+ DFGLA++ G + T VVTR+YRA Sbjct: 135 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-TSFMMTPYVVTRYYRA 193 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ G Y VD+W+VGCI+ E++ PG +DQ ++ E LGTP E + Sbjct: 194 PEVILGM-GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 252 Query: 241 C-SLPDYVTFK------SFPGIPLHHIFSAAGD-------DLLDLIQGLFLFNPCARITA 286 ++ +YV + +FP + +F A + DL+ + + +P RI+ Sbjct: 253 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312 Query: 287 TQALKMKYFSNRP 299 AL+ Y + Sbjct: 313 DDALQHPYINVWY 325 >5AIR-A nrPDB Length = 430 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 103/302 (34%), Positives = 149/302 (49%), Gaps = 21/302 (6%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y +G G F VY+A+ ++ ++VAIKK+ R + RE++++++L H Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKLDH 116 Query: 72 PNIIGLLDAF----GHKSNISL--VFDFMETDLEVIIKDNSL---VLTPSHIKAYMLMTL 122 NI+ L F K + L V D++ + + + S L ++K YM Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 176 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 + L Y+H I HRD+KP NLLLD + VLKL DFG AK + +R+YRAP Sbjct: 177 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAP 235 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+FGA Y +D+W+ GC+LAELLL P PGDS +DQL I + LGTPT EQ +M Sbjct: 236 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 295 Query: 242 SLPDYVTFKSFPGIPLHHIF-SAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 F P +F + + L L + P AR+T +A +F Sbjct: 296 PNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 355 Query: 301 PT 302 P Sbjct: 356 PN 357 >3Q5I-A nrPDB Length = 504 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 82/324 (25%), Positives = 132/324 (40%), Gaps = 38/324 (11%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAK--------DGINRTAL 60 + Y K+ LG G + V ++KN + AIK IK + + + + Sbjct: 35 GESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIY 94 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 EI LL+ L HPNII L D F K LV +F E N M Sbjct: 95 NEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQ 154 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENG---VLKLADFGLAKSFGSPNRAYTHQVVTRW 177 L G+ YLH+H I+HRD+KP N+LL+ +K+ DFGL+ SF S + ++ T + Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLS-SFFSKDYKLRDRLGTAY 213 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 Y APE+L + Y D+W+ G I+ LL P G +D D + ++ + W Sbjct: 214 YIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDW 271 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 ++ D+ +LI+ + ++ R TA +AL ++ Sbjct: 272 KNI------------------------SDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK 307 Query: 298 RPGPTPGCQLPRPNCPVETLKEQS 321 + +++ Sbjct: 308 YANNINKSDQKTLCGALSNMRKFE 331 >4JG6-A nrPDB Length = 355 Score = 280 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 82/338 (24%), Positives = 140/338 (41%), Gaps = 47/338 (13%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL-QELS 70 YE + +G G ++ + K TN A+K I R + EI++L + Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE---------EIEILLRYGQ 87 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HPNII L D + + +V + M+ L+ I++ + A + + +EYL Sbjct: 88 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVLFTITKTVEYL 145 Query: 129 HQHWILHRDLKPNNLL-LDENGV---LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 H ++HRDLKP+N+L +DE+G +++ DFG AK + N T + APE+L Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFL---PGDSDLDQLTRIFETLGTPTEEQWPDMC 241 + Y D+W++G +L +L P D+ + L RI + + W Sbjct: 206 E-RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW---- 260 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 ++ D DL+ + +P R+TA L+ + + Sbjct: 261 --------------------NSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHW-DQ 299 Query: 302 TPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGG 339 P QL R + P + A+ R ++ LE G Sbjct: 300 LPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVG 337 >4RGJ-A nrPDB Length = 520 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 80/319 (25%), Positives = 137/319 (42%), Gaps = 34/319 (10%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y+ + LG+G F V +RDK+T AIK I H D + LRE++LL+ L Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTD--KESLLREVELLKML 117 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 H NI+ L + F + LV D + + L G+ Y+H Sbjct: 118 DHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMH 177 Query: 130 QHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 ++ ++HRDLKP N+LL E+ ++K+ DFGL+ F ++ ++ T +Y AP++L Sbjct: 178 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF-EYSKKMKDKIGTAYYIAPDVLH 236 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G Y D+W+ G IL LL P G ++ D L ++ T Q+ + Sbjct: 237 GT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKI----- 289 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG-PTPG 304 D DLI+ + ++ RI+A AL+ ++ Sbjct: 290 -------------------SDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLN 330 Query: 305 CQLPRPNCPVETLKEQSNP 323 +P + +++ + Sbjct: 331 IDIPSLELSIANIRQFQST 349 >2VN9-A nrPDB Length = 301 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 85/295 (28%), Positives = 124/295 (42%), Gaps = 31/295 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 S Y+ + LG+G F+ V + T Q A K I S ++ RE ++ Sbjct: 1 SMTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARD---HQKLEREARIC 57 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + L HPNI+ L D+ + LVFD + + + + L+ + Sbjct: 58 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 117 Query: 127 YLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + H + I+HRDLKP NLLL + +KLADFGLA +A+ T Y +PE+ Sbjct: 118 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 L YG VDMWA G IL LL+ P D DQ R+++ + Sbjct: 178 LR-KDPYGKPVDMWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAY--------- 223 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + + DLI + NP RITA++ALK + R Sbjct: 224 -------DFPSPEWDTVTP----EAKDLINKMLTINPAKRITASEALKHPWICQR 267 >3RP9-A nrPDB Length = 458 Score = 276 bits (706), Expect = 9e-75, Method: Composition-based stats. Identities = 115/405 (28%), Positives = 170/405 (41%), Gaps = 75/405 (18%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 RYE +G G + V +A DK ++VAIKKI R + LREI +L Sbjct: 52 PDRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI---LRVFEDLIDCKRILREIAILNR 108 Query: 69 LSHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 L+H +++ +LD K + +V + ++D + + + + LT HIK + L Sbjct: 109 LNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFR-TPVYLTELHIKTLLYNLLV 167 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP------------------ 165 G++Y+H ILHRDLKP N L++++ +K+ DFGLA++ P Sbjct: 168 GVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 166 ---------NRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-------- 208 R T VVTRWYRAPEL+ Y +D+W++GCI AELL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 209 ---RVPFLPGDS--------------------DLDQLTRIFETLGTPTEEQWPDMCSLPD 245 R P PG S + DQL IF LGTP+EE + Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 246 YVTFKSFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 + FP G L F A+ D + L++ + +FNP RIT + L +F Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 303 PGCQLPR----PNCPVETLKEQSNPALAIKRKRTEALEQGGLPKK 343 P + E +K + E LP++ Sbjct: 408 VETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPE-IQLPRR 451 >5U6Y-A nrPDB Length = 461 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 124/290 (42%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + Q A K I S ++ RE ++ + L H Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARD---HQKLEREARICRLLKH 58 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 PNI+ L D+ + + L+FD + + + + L+ + + HQ Sbjct: 59 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 132 WILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 ++HRDLKP NLLL + +KLADFGLA +A+ T Y +PE+L Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR-KD 177 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 YG VD+WA G IL LL+ P D DQ R+++ + Sbjct: 178 PYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAY-------------- 219 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + + DLI + NP RITA +ALK + S+R Sbjct: 220 --DFPSPEWDTVTP----EAKDLINKMLTINPSKRITAAEALKHPWISHR 263 >3N9X-A nrPDB Length = 432 Score = 274 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 109/349 (31%), Positives = 153/349 (43%), Gaps = 62/349 (17%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 Y +G G + VY A DKNT + VAIKK+ + LREI +L Sbjct: 23 HVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDC---KRILREITIL 79 Query: 67 QELSHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L II L D + +V + ++DL+ + K + LT HIK + Sbjct: 80 NRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFK-TPIFLTEEHIKTILYNL 138 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP---------------- 165 L G ++H+ I+HRDLKP N LL+++ +K+ DFGLA++ S Sbjct: 139 LLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPG 198 Query: 166 ------NRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-----------L 208 + T VVTRWYRAPEL+ Y +D+W+ GCI AELL Sbjct: 199 PHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTN 258 Query: 209 RVPFLPG-----------------DSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 R P PG S+ DQL IF +GTPTE+ ++ K Sbjct: 259 RFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKL 318 Query: 252 FP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 FP I L + + DD ++L++ + FNP RIT QAL Y + Sbjct: 319 FPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >5Y86-A nrPDB Length = 588 Score = 274 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 101/378 (26%), Positives = 168/378 (44%), Gaps = 60/378 (15%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A RYE L +G+G F V + D Q VA+K ++ R +R A EI++L+ Sbjct: 206 AYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR------FHRQAAEEIRILEH 259 Query: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMT 121 L N+I +L++F ++++ + F+ + DL +IK N + ++ + Sbjct: 260 LKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 LQ L+ LH++ I+H DLKP N+LL +G K+ DFG + + + +R+YR Sbjct: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYR 376 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE++ G+R Y +D+W+ GCILAELL P PG+ + DQL + E LG P + Sbjct: 377 APEIILGSR-YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 435 Query: 240 MCSLPDYVTFKSFP------------------------------GIPLHHIFSAAGD-DL 268 ++ K P D Sbjct: 436 SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLF 495 Query: 269 LDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETL--KEQSNPALA 326 ++ ++ ++P AR+T QAL+ + S +PRP ++ + K NPA A Sbjct: 496 IEFLKRCLHWDPSARLTPAQALRHPWISK--------SVPRPLTTIDKVSGKRVVNPASA 547 Query: 327 IKRKRTEALEQGGLPKKL 344 + ++ G+ KL Sbjct: 548 FQGLGSKLPPVVGIANKL 565 >5WAX-A nrPDB Length = 310 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 133/328 (40%), Gaps = 39/328 (11%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M + + RYE + +G G F R++ Q+VA+K I+ G + I+ Sbjct: 2 MDMPIMHDGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG------EKIDENVQ 55 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 REI + L HPNII + +++++V ++ N+ + + + Sbjct: 56 REIINHRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 115 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENG--VLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + G+ Y H + HRDLK N LLD + LK+ DFG +KS + V T Y Sbjct: 116 LISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKS-SVLHSQPKSTVGTPAY 174 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+L G D+W+ G L +L+ PF D + I LG Sbjct: 175 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV------ 228 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-S 296 S+PDYV + DLI +F+ NP RIT + +F Sbjct: 229 --QYSIPDYVHI---------------SPECQDLISRIFVANPATRITIPEIRNHPWFLK 271 Query: 297 NRP-----GPTPGCQLPRPNCPVETLKE 319 N P T Q P P++++ E Sbjct: 272 NLPADLMDDSTMSKQYEEPEQPMQSMDE 299 >5FG8-A nrPDB Length = 285 Score = 274 bits (700), Expect = 5e-74, Method: Composition-based stats. Identities = 80/293 (27%), Positives = 126/293 (43%), Gaps = 31/293 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + Y+ + LG+G F+ V + K+T A K I + + RE ++ ++ Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARD---FQKLEREARICRK 69 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L D+ ++ LVFD + + + + L+ + + Sbjct: 70 LHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHC 129 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQ+ ++HRDLKP NLLL + +KLADFGLA ++A+ T Y +PE+L Sbjct: 130 HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL- 188 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ R++ + Sbjct: 189 KKEPYGKSVDIWACGVILYILLVGYPPF---WDEDQ-HRLYSQIKAGAY----------- 233 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 +P + + +LI + NP RITA +ALK + R Sbjct: 234 -----DYPSPEWDTVTP----EAKNLINQMLTVNPNKRITAAEALKHPWICQR 277 >4E7W-A nrPDB Length = 394 Score = 273 bits (699), Expect = 7e-74, Method: Composition-based stats. Identities = 105/328 (32%), Positives = 159/328 (48%), Gaps = 28/328 (8%) Query: 1 MALDVKSRAKR---YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR 57 +A D K+ +R Y +G G F V++A+ +++ VAIKK+ R + Sbjct: 28 LASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------ 80 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKSN------ISLVFDFMETDLEV---IIKDNSLV 108 RE+++++ + HPN++ L F + ++LV +++ + Sbjct: 81 ---RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQT 137 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE-NGVLKLADFGLAKSFGSPNR 167 + IK YM L+ L Y+H I HRD+KP NLLLD +GVLKL DFG AK + Sbjct: 138 MPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIA-GE 196 Query: 168 AYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 + +R+YRAPEL+FGA Y +D+W+ GC++AEL+ P PG+S +DQL I + Sbjct: 197 PNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIK 256 Query: 228 TLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIF-SAAGDDLLDLIQGLFLFNPCARITA 286 LGTP+ EQ M F P +F D +DLI L + P AR+TA Sbjct: 257 VLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTA 316 Query: 287 TQALKMKYFSNRP---GPTPGCQLPRPN 311 +AL +F P + P Sbjct: 317 IEALCHPFFDELRTGEARMPNGRELPPL 344 >4LG4-A nrPDB Length = 299 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 82/328 (25%), Positives = 143/328 (43%), Gaps = 47/328 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 K + ++ L+ LGEG + +V+KA K + Q+VAIK++ + + + ++EI Sbjct: 6 TKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-------ESDLQEIIKEIS 58 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 ++Q+ P ++ ++ +++ +V ++ + II+ + L I + TL+ Sbjct: 59 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 118 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GLEYLH +HR++K N+LL+ G KLADFG+A + T ++ APE+ Sbjct: 119 GLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 178 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y D+W++G E+ P +D+ + IF P P Sbjct: 179 IQEI-GYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNP-----PPTFRK 229 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P+ DD D ++ + NP R TATQ L+ + N Sbjct: 230 PELW-----------------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK---- 268 Query: 304 GCQLPRPNCPVETLKEQSNPALAIKRKR 331 PV L++ A+ IK KR Sbjct: 269 ---------PVSILRDLITEAMEIKAKR 287 >2VZ6-A nrPDB Length = 313 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 124/290 (42%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ + LG+G F+ V + Q A K I S ++ RE ++ + L H Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARD---HQKLEREARICRLLKH 80 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 PNI+ L D+ + + L+FD + + + + L+ + + HQ Sbjct: 81 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 140 Query: 132 WILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 ++HRDLKP NLLL + +KLADFGLA +A+ T Y +PE+L Sbjct: 141 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR-KD 199 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 YG VD+WA G IL LL+ P D DQ R+++ + Sbjct: 200 PYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAY-------------- 241 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + + DLI + NP RITA +ALK + S+R Sbjct: 242 --DFPSPEWDTVTP----EAKDLINKMLTINPSKRITAAEALKHPWISHR 285 >3NIE-A nrPDB Length = 429 Score = 272 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 108/355 (30%), Positives = 154/355 (43%), Gaps = 65/355 (18%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 YE +G G + VY A DKN N+ VAIKK+ + LREI +L Sbjct: 27 PDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDC---KRILREITILNR 83 Query: 69 LSHPNIIGLLDAFGHKS-----NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 L II L D + + +V + ++DL+ + K + LT H+K + L Sbjct: 84 LKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFK-TPIFLTEQHVKTILYNLLL 142 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP------------------ 165 G +++H+ I+HRDLKP N LL+++ +K+ DFGLA++ S Sbjct: 143 GEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEP 202 Query: 166 -------NRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL----------- 207 + T VVTRWYRAPEL+ Y +D+W+ GCI AELL Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPT 262 Query: 208 LRVPFLPG-----------------DSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 R P PG S+ DQL IF +GTP EE + K Sbjct: 263 NRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIK 322 Query: 251 SFP---GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 FP GI L +S+ + +DL++ + FN RIT +AL Y + Sbjct: 323 LFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKEN 377 >2V7O-A nrPDB Length = 336 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 84/293 (28%), Positives = 123/293 (41%), Gaps = 31/293 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Y+ + LG+G F+ V + K Q A K I S ++ RE ++ + Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARD---HQKLEREARICRL 86 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L D+ + LVFD + + + + L+ + ++ Sbjct: 87 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHI 146 Query: 129 HQHWILHRDLKPNNLLLDENGV---LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQH I+HRDLKP NLLL +KLADFGLA +A+ T Y +PE+L Sbjct: 147 HQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLR 206 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ ++++ + Sbjct: 207 -KDPYGKPVDIWACGVILYILLVGYPPF---WDEDQ-HKLYQQIKAGAY----------- 250 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + + +LI + NP RITA QALK + R Sbjct: 251 -----DFPSPEWDTVTP----EAKNLINQMLTINPAKRITADQALKHPWVCQR 294 >6AO5-A nrPDB Length = 362 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 82/328 (25%), Positives = 143/328 (43%), Gaps = 47/328 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 K + ++ L+ LGEG + +V+KA K + Q+VAIK++ + + + ++EI Sbjct: 5 TKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-------ESDLQEIIKEIS 57 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 ++Q+ P ++ ++ +++ +V ++ + II+ + L I + TL+ Sbjct: 58 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 117 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 GLEYLH +HR++K N+LL+ G KLADFG+A + T ++ APE+ Sbjct: 118 GLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV 177 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y D+W++G E+ P +D+ + IF P P Sbjct: 178 IQEI-GYNCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNP-----PPTFRK 228 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P+ DD D ++ + NP R TATQ L+ + N Sbjct: 229 PELW-----------------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK---- 267 Query: 304 GCQLPRPNCPVETLKEQSNPALAIKRKR 331 PV L++ A+ IK KR Sbjct: 268 ---------PVSILRDLITEAMEIKAKR 286 >4UZD-A nrPDB Length = 287 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 78/297 (26%), Positives = 122/297 (41%), Gaps = 33/297 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + +E LG+G+F VY AR+K + I+A+K + K G+ RE+++ L Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVL--FKAQLEKAGVEHQLRREVEIQSHL 65 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HPNI+ L F + + L+ ++ Y+ L Y H Sbjct: 66 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCH 125 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 ++HRD+KP NLLL G LK+ADFG + +P+ T T Y PE++ G RM Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEG-RM 182 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 + VD+W++G + E L+ P ++ + RI T PD+VT Sbjct: 183 HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTF-----------PDFVT- 230 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 + DLI L NP R + L+ + + CQ Sbjct: 231 ----------------EGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQ 271 >2BDW-A nrPDB Length = 362 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 83/293 (28%), Positives = 123/293 (41%), Gaps = 32/293 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + Y+ + LG+G F+ V + K T A K I S + RE ++ ++ Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD---FQKLEREARICRK 84 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L D+ +S LVFD + + + + L+ + Y Sbjct: 85 LQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 144 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H + I+HR+LKP NLLL + +KLADFGLA + A+ T Y +PE+L Sbjct: 145 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVL- 202 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Y VD+WA G IL LL+ P D DQ R++ + Sbjct: 203 KKDPYSKPVDIWACGVILYILLVGYPPF---WDEDQ-HRLYAQIKAGAY----------- 247 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 +P + + LI + NP RITA QALK+ + NR Sbjct: 248 -----DYPSPEWDTVTP----EAKSLIDSMLTVNPKKRITADQALKVPWICNR 291 >3BHH-A nrPDB Length = 295 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 120/295 (40%), Gaps = 31/295 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 S Y+ + +G+G F+ V + T A K I S ++ RE ++ Sbjct: 1 SMTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARD---HQKLEREARIC 57 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + L H NI+ L D+ + LVFD + + + + L+ + Sbjct: 58 RLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVL 117 Query: 127 YLHQHWILHRDLKPNNLLLDENGV---LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + HQ ++HRDLKP NLLL +KLADFGLA +A+ T Y +PE+ Sbjct: 118 HCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 177 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 L YG VD+WA G IL LL+ P D DQ ++++ + Sbjct: 178 LR-KEAYGKPVDIWACGVILYILLVGYPPF---WDEDQ-HKLYQQIKAGAY--------- 223 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + + +LI + NP RITA +ALK + R Sbjct: 224 -------DFPSPEWDTVTP----EAKNLINQMLTINPAKRITAHEALKHPWVCQR 267 >5YKS-A nrPDB Length = 377 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 126/313 (40%), Gaps = 35/313 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ LG G FA V AR T + VA+K I G +E++ ++ + H Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATG---HLFQEVRCMKLVQH 93 Query: 72 PNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 PNI+ L + ++ + L+ + D+ I + L K Y + + Y H+ Sbjct: 94 PNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHK 153 Query: 131 HWILHRDLKPNNL-LLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 ++HRDLKP N+ ++ G++KL DFG + F P + T + Y APE+L G Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEILLGDEY 212 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 VD+W++G IL L+ P +D + LT I + T Sbjct: 213 DAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYT------------------ 254 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPR 309 + S + DLI + +P R + + + P+P + Sbjct: 255 ----------VPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGV-DPSPATKYNI 303 Query: 310 PNCPVETLKEQSN 322 P + L E+ + Sbjct: 304 PLVSYKNLSEEEH 316 >3SOA-A nrPDB Length = 444 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 80/293 (27%), Positives = 124/293 (42%), Gaps = 31/293 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + Y+ + LG+G F+ V + Q A I S ++ RE ++ + Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARD---HQKLEREARICRL 66 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L D+ + + L+FD + + + + L+ + + Sbjct: 67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 126 Query: 129 HQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 HQ ++HR+LKP NLLL + +KLADFGLA +A+ T Y +PE+L Sbjct: 127 HQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 186 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 YG VD+WA G IL LL+ P D DQ R+++ + Sbjct: 187 -KDPYGKPVDLWACGVILYILLVGYPPF---WDEDQ-HRLYQQIKAGAY----------- 230 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP + + DLI + NP RITA +ALK + S+R Sbjct: 231 -----DFPSPEWDTVTP----EAKDLINKMLTINPSKRITAAEALKHPWISHR 274 >3TAC-A nrPDB Length = 361 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 82/334 (24%), Positives = 136/334 (40%), Gaps = 33/334 (9%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 MA D YE + +G+G F+ V + ++ T Q A+K + + + + Sbjct: 17 MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLK 76 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDN---SLVLTPSHIKA 116 RE + L HP+I+ LL+ + + +VF+FM+ DL I V + + Sbjct: 77 REASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASH 136 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQV 173 YM L+ L Y H + I+HRD+KP+ +LL + + +KL FG+A G +V Sbjct: 137 YMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRV 196 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT 233 T + APE++ YG VD+W G IL LL G + R+FE + Sbjct: 197 GTPHFMAPEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIKGK 250 Query: 234 EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 + P +S + DL++ + + +P RIT +AL Sbjct: 251 YKMNP--------------------RQWSHISESAKDLVRRMLMLDPAERITVYEALNHP 290 Query: 294 YFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAI 327 + R LP + + A+ Sbjct: 291 WLKERDRYAYKIHLPETVEQLRKFNARRKLKGAV 324 >4FG9-A nrPDB Length = 320 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 88/341 (25%), Positives = 135/341 (39%), Gaps = 40/341 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A D++ Y+ D LG G F+ V A DK T ++VAIK I EA +G + Sbjct: 13 AEDIR---DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAK----EALEGKEGSMEN 65 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 EI +L ++ HPNI+ L D + ++ L+ + T + Sbjct: 66 EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQV 125 Query: 122 LQGLEYLHQHWILHRDLKPNNLL---LDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L ++YLH I+HRDLKP NLL LDE+ + ++DFGL+K P + T Y Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGY 184 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE+L + Y VD W++G I LL P ++D +I + W Sbjct: 185 VAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWD 243 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 D+ D D I+ L +P R T QAL+ + + Sbjct: 244 DI------------------------SDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGD 279 Query: 299 PG----PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEAL 335 ++ +Q+ A A+ R + Sbjct: 280 TALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQ 320 >2QNJ-A nrPDB Length = 328 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 126/319 (39%), Gaps = 32/319 (10%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M D + Y L +G+G FA V AR T + VAIK I + + Sbjct: 3 MGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTS---LQKLF 59 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 RE+++++ L+HPNI+ L + + + L+ ++ + ++ Sbjct: 60 REVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQ 119 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + ++Y HQ I+HRDLK NLLLD + +K+ADFG + F + T + Y A Sbjct: 120 IVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDT-FCGSPPYAA 178 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PEL G + G VD+W++G IL L+ G + + R+ Sbjct: 179 PELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR--------- 229 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 +P Y+ D +L++ + NP R T Q +K ++ + Sbjct: 230 --IPFYM-----------------STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 270 Query: 301 PTPGCQLPRPNCPVETLKE 319 P + K Sbjct: 271 EDELKPFVEPELDISDQKR 289 >3E3P-A nrPDB Length = 360 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 107/359 (29%), Positives = 168/359 (46%), Gaps = 35/359 (9%) Query: 2 ALDVKSR--AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA 59 A D +SR R++ G+G F TV ++K+T VAIKK+ R Sbjct: 13 AADERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN-------- 64 Query: 60 LREIKLLQEL---SHPNIIGLLDAFG-----HKSNISL--VFDFMETDLEVIIK---DNS 106 RE++++Q+L HPNI+ L F + +I L V +++ L + Sbjct: 65 -RELQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQ 123 Query: 107 LVLTPSHIKAYMLMTLQGLEYLH--QHWILHRDLKPNNLLLDE-NGVLKLADFGLAKSFG 163 + P IK ++ ++ + LH + HRD+KP+N+L++E +G LKL DFG AK Sbjct: 124 VAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKL- 182 Query: 164 SPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLT 223 SP+ + +R+YRAPEL+FG + Y VD+W+VGCI AE++L P GD+ QL Sbjct: 183 SPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLH 242 Query: 224 RIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG----DDLLDLIQGLFLFN 279 I LG P+ E + V + GIP ++FS + DL+ L + Sbjct: 243 EIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYL 302 Query: 280 PCARITATQALKMKYFSNRPGPTPGCQLP-RPNCPVETLKEQSNPALAIKRKRTEALEQ 337 P R+ +AL YF P +LP + P + + N + + L + Sbjct: 303 PEERMKPYEALCHPYFDELHD--PATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKLVR 359 >3D2K-A nrPDB Length = 272 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 121/294 (41%), Gaps = 33/294 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + ++ LG+G+F VY AR++ + I+A+K + K G+ RE+++ L Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVL--FKTQLEKAGVEHQLRREVEIQSHL 69 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HPNI+ L F + + L+ ++ Y+ L Y H Sbjct: 70 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCH 129 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 ++HRD+KP NLLL NG LK+ADFG + +P+ T T Y PE++ G RM Sbjct: 130 SKRVIHRDIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEG-RM 186 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 + VD+W++G + E L+ +P + + RI T PD+VT Sbjct: 187 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTF-----------PDFVT- 234 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + DLI L N R+T + L+ + Sbjct: 235 ----------------EGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPS 272 >2JC6-A nrPDB Length = 334 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 80/306 (26%), Positives = 123/306 (40%), Gaps = 36/306 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A D+K K +E + LG G F+ V A +K T ++ A+K I +A G + Sbjct: 17 AEDIK---KIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPK----KALKGKESSIEN 69 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 EI +L+++ H NI+ L D + +++ LV + T + Sbjct: 70 EIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQV 129 Query: 122 LQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L + YLH+ I+HRDLKP NLL DE + ++DFGL+K G + T T Y Sbjct: 130 LDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST-ACGTPGY 188 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE+L + Y VD W++G I LL P ++D +I + W Sbjct: 189 VAPEVL-AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWD 247 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 D+ D D I+ L +P R T QA + + + Sbjct: 248 DI------------------------SDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGD 283 Query: 299 PGPTPG 304 Sbjct: 284 TALNKN 289 >3MN3-A nrPDB Length = 271 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 83/290 (28%), Positives = 125/290 (43%), Gaps = 32/290 (11%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + Y+ + LGEG F V A T Q VA+K I + AK + REI L Sbjct: 1 AHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIIN--KKVLAKSDMQGRIEREISYL 58 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + L HP+II L D K I +V ++ +L I ++ + + + +E Sbjct: 59 RLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRD-KMSEQEARRFFQQIISAVE 117 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Y H+H I+HRDLKP NLLLDE+ +K+ADFGL+ N T + Y APE++ G Sbjct: 118 YCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTS-CGSPNYAAPEVISG 176 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G VD+W+ G IL +L R +S I + T LP + Sbjct: 177 KLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYT-----------LPKF 225 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + LI+ + + NP RI+ + ++ +F Sbjct: 226 L-----------------SPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >3KK8-A nrPDB Length = 284 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 83/293 (28%), Positives = 123/293 (41%), Gaps = 32/293 (10%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + Y+ + LG+G F+ V + K T A K I S + RE ++ ++ Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARD---FQKLEREARICRK 61 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L HPNI+ L D+ +S LVFD + + + + L+ + Y Sbjct: 62 LQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYC 121 Query: 129 HQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 H + I+HR+LKP NLLL + +KLADFGLA + A+ T Y +PE+L Sbjct: 122 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVL- 179 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 Y VD+WA G IL LL+ P D DQ R++ + Sbjct: 180 KKDPYSKPVDIWACGVILYILLVGYPPF---WDEDQ-HRLYAQIKAGAY----------- 224 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 +P + + LI + NP RITA QALK+ + NR Sbjct: 225 -----DYPSPEWDTVTP----EAKSLIDSMLTVNPKKRITADQALKVPWICNR 268 >4NIF-A nrPDB Length = 333 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 81/341 (23%), Positives = 139/341 (40%), Gaps = 49/341 (14%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL-Q 67 + Y + +G G ++ + K TN A+K I R ++ EI++L + Sbjct: 7 SDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE---------EIEILLR 57 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 HPNII L D + ++ LV + M L+ I++ + + + + Sbjct: 58 YGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQK--FFSEREASFVLHTIGKTV 115 Query: 126 EYLHQHWILHRDLKPNNLL-LDENGV---LKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 EYLH ++HRDLKP+N+L +DE+G L++ DFG AK + N T + AP Sbjct: 116 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 175 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFL---PGDSDLDQLTRIFETLGTPTEEQWP 238 E+L + Y G D+W++G +L +L P D+ + LTRI T + W Sbjct: 176 EVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW- 233 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + + DL+ + +P R+TA Q L+ + + + Sbjct: 234 -----------------------NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQK 270 Query: 299 PGPTPGCQLPRPNCPVETLKEQSNPALAIKRKR-TEALEQG 338 P QL + + A+ + T L+ Sbjct: 271 -DKLPQSQLSHQDL-QLVKGAMAATYSALNSSKPTPQLKPI 309 >3F3Z-A nrPDB Length = 277 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 80/295 (27%), Positives = 123/295 (41%), Gaps = 35/295 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y + +G G + V A K T A KKI + +EI++++ L H Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD-----RFKQEIEIMKSLDH 65 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 PNII L + F ++I LV + + V S M L + Y H+ Sbjct: 66 PNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKL 125 Query: 132 WILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 + HRDLKP N L + LKL DFGLA F P + +V T +Y +P++L G Sbjct: 126 NVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARF-KPGKMMRTKVGTPYYVSPQVLEG-- 182 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 +YG D W+ G ++ LL P +D + + +I E T E+ W ++ Sbjct: 183 LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNV-------- 234 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 LI+ L +P RIT+ QAL+ ++F + +P Sbjct: 235 ----------------SPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQLSSSP 273 >5KZ7-A nrPDB Length = 346 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 78/336 (23%), Positives = 136/336 (40%), Gaps = 34/336 (10%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 + D + Y L +G+G FA V AR T + VA+K I + + + R Sbjct: 25 SADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSS---LQKLFR 81 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E+++++ L+HPNI+ L + + + LV ++ + +A Sbjct: 82 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 141 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 + ++Y HQ +I+HRDLK NLLLD + +K+ADFG + F N+ T + Y AP Sbjct: 142 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDT-FCGSPPYAAP 200 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL G + G VD+W++G IL L+ G + + R+ Sbjct: 201 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR---------- 250 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS--NRP 299 +P Y+ D +L++ + NP R T Q +K ++ + + Sbjct: 251 -IPFYM-----------------STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED 292 Query: 300 GPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEAL 335 P P+ E + + ++L Sbjct: 293 DELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSL 328 >4L42-A nrPDB Length = 346 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 76/344 (22%), Positives = 138/344 (40%), Gaps = 39/344 (11%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTA 59 K R + +E L LG+G + V++ R NT +I A+K +K T Sbjct: 11 GPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTK 70 Query: 60 LREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYML 119 E +L+E+ HP I+ L+ AF + L+ +++ + + + Y+ Sbjct: 71 A-ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLA 129 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L +LHQ I++RDLKP N++L+ G +KL DFGL K T Y Sbjct: 130 EISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYM 189 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L + + VD W++G ++ ++L P G++ + +I + Sbjct: 190 APEILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK---------- 238 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKY 294 +LP Y+T + DL++ L N +R+ A + + Sbjct: 239 -LNLPPYLT-----------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPF 280 Query: 295 FSNRPGPTPGC-QLPRPNCPVETLKEQSNPALAIKRKRTEALEQ 337 F + ++ P P+ +E + + ++T Sbjct: 281 FRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSP 324 >2Y7J-A nrPDB Length = 365 Score = 264 bits (674), Expect = 6e-71, Method: Composition-based stats. Identities = 83/297 (27%), Positives = 131/297 (44%), Gaps = 34/297 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHR---SEAKDGINRTALREIKLL 66 ++Y+ D +G G + V + + T A+K +++ E + + RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 67 QEL-SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 +++ HP+II L+D++ S + LVFD M + L+ ++ M L+ + Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 +LH + I+HRDLKP N+LLD+N ++L+DFG + P T Y APE+L Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL-EPGEKLRELCGTPGYLAPEILK 272 Query: 186 GA-----RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 + YG VD+WA G IL LL P + L I E + +W D Sbjct: 273 CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDR 332 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 S + DLI L +P AR+TA QAL+ +F Sbjct: 333 SS------------------------TVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >5ES1-A nrPDB Length = 328 Score = 263 bits (673), Expect = 7e-71, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 129/337 (38%), Gaps = 38/337 (11%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 + + Y L +G+G FA V AR T + VAIK I + + + RE+ Sbjct: 9 EEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSS---LQKLFREV 65 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 ++++ L+HPNI+ L + + + LV ++ + + +A + Sbjct: 66 RIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVS 125 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + Y HQ I+HRDLK NLLLD +K+ADFG + F ++ T + Y APEL Sbjct: 126 AVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDT-FCGSPPYAAPEL 184 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 G + G VD+W++G IL L+ G + + R+ + Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYR-----------V 233 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P Y+ D +++ + NP R T Q +K K+ + Sbjct: 234 PFYM-----------------STDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEE 276 Query: 304 GCQLPRPNCP------VETLKEQSNPALAIKRKRTEA 334 P +E + IK T Sbjct: 277 LKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQ 313 >2I6L-A nrPDB Length = 320 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 101/317 (31%), Positives = 157/317 (49%), Gaps = 27/317 (8%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 RY L LG G V+ A D + ++ VAIKKI + ALREIK+++ Sbjct: 10 GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI-----VLTDPQSVKHALREIKIIRR 64 Query: 69 LSHPNIIGLL--------------DAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHI 114 L H NI+ + + +++ +V ++METDL +++ L H Sbjct: 65 LDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQG--PLLEEHA 122 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFG---SPNRAYT 170 + +M L+GL+Y+H +LHRDLKP NL ++ E+ VLK+ DFGLA+ S + Sbjct: 123 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 182 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 +VT+WYR+P LL Y +DMWA GCI AE+L G +L+Q+ I E++ Sbjct: 183 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIP 242 Query: 231 TPTEEQWPDMCS-LPDYVTFK-SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 EE ++ S +P Y+ + P PL + + +D ++ + F+P R+TA + Sbjct: 243 VVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 Query: 289 ALKMKYFSNRPGPTPGC 305 AL Y S P Sbjct: 303 ALSHPYMSIYSFPMDEP 319 >5ZTN-A nrPDB Length = 429 Score = 263 bits (672), Expect = 9e-71, Method: Composition-based stats. Identities = 104/341 (30%), Positives = 166/341 (48%), Gaps = 50/341 (14%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 A RYE L +G+G F V KA D +Q VA+K ++ R +R A EI++ Sbjct: 93 DHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR------FHRQAAEEIRI 146 Query: 66 LQELSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYM 118 L+ L N+I +L+ F +++I + F+ + +L +IK N + ++ + Sbjct: 147 LEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA 206 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTR 176 LQ L+ LH++ I+H DLKP N+LL + G +K+ DFG + R YT + +R Sbjct: 207 HSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS--CYEHQRVYT-YIQSR 263 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 +YRAPE++ GAR YG+ +DMW++GCILAELL P LPG+ + DQL + E LG P+++ Sbjct: 264 FYRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKL 322 Query: 237 WPDMCSLPDYVTFKSFP--------------------------GIPLHHIFSAA-----G 265 ++V+ K +P G P + A Sbjct: 323 LDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD 382 Query: 266 DDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 LD ++ ++P R+T QAL+ + R P + Sbjct: 383 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGE 423 >3UC3-A nrPDB Length = 361 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 80/327 (24%), Positives = 130/327 (39%), Gaps = 39/327 (11%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 + + + + RY+ + +G G F RDK T ++VA+K I+ G I+ Sbjct: 11 LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA------AIDENVQ 64 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 REI + L HPNI+ + ++++++ ++ N+ + + + Sbjct: 65 REIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQ 124 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDEN--GVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L G+ Y H I HRDLK N LLD + LK+ DFG +KS + V T Y Sbjct: 125 LLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKS-SVLHSQPKSTVGTPAY 183 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+L G D+W+ G L +L+ PF + D I L Sbjct: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVK----- 238 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-S 296 S+PD + + LI +F+ +P RI+ + +F Sbjct: 239 ---YSIPDDIRI---------------SPECCHLISRIFVADPATRISIPEIKTHSWFLK 280 Query: 297 NRPG-----PTPGCQLPRPNCPVETLK 318 N P G Q P P+++L Sbjct: 281 NLPADLMNESNTGSQFQEPEQPMQSLD 307 >3EB0-A nrPDB Length = 383 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 86/343 (25%), Positives = 151/343 (44%), Gaps = 53/343 (15%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 +++ +K+Y LG G F V + D + + A+KK+ R + RE+ Sbjct: 2 LETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN---------RELD 52 Query: 65 LLQELSHPNIIGLLDAF--------------------------------------GHKSN 86 +++ L H NII L+D F Sbjct: 53 IMKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKY 112 Query: 87 ISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNL 143 ++++ +++ L ++K + + + I Y+ + + ++H I HRD+KP NL Sbjct: 113 LNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNL 172 Query: 144 LLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCI 202 L++ ++ LKL DFG AK P+ + +R+YRAPEL+ GA Y +D+W++GC+ Sbjct: 173 LVNSKDNTLKLCDFGSAKKLI-PSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCV 231 Query: 203 LAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS 262 EL+L P G++ +DQL RI + +GTPT+EQ M V F + I Sbjct: 232 FGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILP 291 Query: 263 AAGDD-LLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304 +DL++ + + P RI +A+ +F + Sbjct: 292 EGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYES 334 >5IG1-A nrPDB Length = 344 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 117/292 (40%), Gaps = 32/292 (10%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 +K +G+G F+TV++ +K T ++ A+K I L + REI + L H Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSL---RSSEINKIKREIGICSSLQHE 76 Query: 73 NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 +I+ + AF +S+ LVF+++ A M L L++ H Sbjct: 77 HIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILSALQHCHSKN 136 Query: 133 ILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 I+HRDLKP NLLL D N +K+ DFGLA Y T Y +PE++ Sbjct: 137 IIHRDLKPENLLLASKDPNAPVKITDFGLA-VIMEQGPTYFGFAGTPGYLSPEVIRRV-P 194 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y VD+WA G IL LL+ P + +I +W + + Sbjct: 195 YDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTA------ 248 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 +LI+ + NP R T + L+ + + R P Sbjct: 249 ------------------AKELIKAMLEPNPKRRPTVQELLQHPWIARRDVP 282 >1PHK-A nrPDB Length = 298 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 80/299 (26%), Positives = 121/299 (40%), Gaps = 35/299 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKL----GHRSEAKDGINRTALREIKL 65 + YE + LG G + V + K T + A+K I + +E + L+E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 66 LQELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L+++S HPNII L D + + LVFD M+ + L+ + M L+ Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 + LH+ I+HRDLKP N+LLD++ +KL DFG + P T Y APE++ Sbjct: 137 ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL-DPGEKLREVCGTPSYLAPEII 195 Query: 185 F-----GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 YG VDMW+ G I+ LL P + L I +W D Sbjct: 196 ECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDD 255 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 D + DL+ + P R TA +AL +F Sbjct: 256 ------------------------YSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQY 290 >4JXF-A nrPDB Length = 266 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 76/294 (25%), Positives = 133/294 (45%), Gaps = 32/294 (10%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + ++ + LG+G FA VY+A +T VAIK I +A G+ + E+K Sbjct: 2 IGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKA--GMVQRVQNEVK 59 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + +L HP+I+ L + F + + LV + ++ +K+ + + + +M + Sbjct: 60 IHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIIT 119 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G+ YLH H ILHRDL +NLLL N +K+ADFGLA P+ + T Y +PE Sbjct: 120 GMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE- 178 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + +G+ D+W++GC+ LL+ P D+ + L ++ Sbjct: 179 IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----------------- 221 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + + + S + DLI L NP R++ + L + S Sbjct: 222 -----------LADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSR 264 >2YCR-A nrPDB Length = 323 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 84/305 (27%), Positives = 132/305 (43%), Gaps = 33/305 (10%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHR---SEAKDGINR 57 M++ K+ Y LG G V A ++ T + VAIK I S + Sbjct: 1 MSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPAL 60 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAY 117 EI++L++L+HP II + + F + +V + ME + L + K Y Sbjct: 61 NVETEIEILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLY 119 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVV 174 L ++YLH++ I+HRDLKP N+LL E+ ++K+ DFG +K G + T Sbjct: 120 FYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCG 178 Query: 175 TRWYRAPELL--FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 T Y APE+L G Y VD W++G IL L P Sbjct: 179 TPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQ------------- 225 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 SL D +T + IP +++ + LDL++ L + +P AR T +AL+ Sbjct: 226 --------VSLKDQITSGKYNFIP--EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRH 275 Query: 293 KYFSN 297 + + Sbjct: 276 PWLQD 280 >4REW-A nrPDB Length = 540 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 124/332 (37%), Gaps = 34/332 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + Y D LG G F V + + T VA+K + + REI+ L Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR--SLDVVGKIRREIQNL 60 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + HP+II L S+I +V +++ + L + L G++ Sbjct: 61 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Y H+H ++HRDLKP N+LLD + K+ADFGL+ + S + Y APE++ G Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G VD+W+ G IL LL D +I + + P Y Sbjct: 180 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY-----------TPQY 228 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 + ++ L++ + +P R + + ++F + Sbjct: 229 L-----------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPE 271 Query: 307 LPRPNCPV---ETLKEQSNPALAIKRKRTEAL 335 P + + E LKE + + L Sbjct: 272 DPSYSSTMIDDEALKEVCEKFECSEEEVLSCL 303 >2J90-A nrPDB Length = 304 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 84/292 (28%), Positives = 128/292 (43%), Gaps = 31/292 (10%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQE 68 YE + LG GQFA V K R K T + A K IK S ++ G++R RE+ +L+E Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 + HPNII L D F +K+++ L+ + + LT ++ L G+ YL Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 129 HQHWILHRDLKPNNLLLDE----NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 H I H DLKP N++L + N +KL DFG+A + + T + APE++ Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKI-EAGNEFKNIFGTPEFVAPEIV 204 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 G+ DMW++G I LL G++ + LT I EE Sbjct: 205 -NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEE--------- 254 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 FS + D I+ L + +P R+T Q+L+ + Sbjct: 255 ---------------YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >3H4J-B nrPDB Length = 336 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 138/319 (43%), Gaps = 33/319 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y + LGEG F V A T Q VA+K I + K ++ REI L+ L H Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFIS--RQLLKKSDMHMRVEREISYLKLLRH 68 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P+II L D ++I +V ++ +L I + +T + + + +EY H+H Sbjct: 69 PHIIKLYDVITTPTDIVMVIEYAGGELFDYIVEKKR-MTEDEGRRFFQQIICAIEYCHRH 127 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 I+HRDLKP NLLLD+N +K+ADFGL+ N T + Y APE++ G G Sbjct: 128 KIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTS-CGSPNYAAPEVINGKLYAG 186 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 VD+W+ G +L +L+ D + + +F+ + + +PD++ Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPF----DDEFIPNLFK-------KVNSCVYVMPDFL---- 231 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS-NRPGPTPGCQLPRP 310 LI+ + + +P RIT + + +F+ N P + + Sbjct: 232 -------------SPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQG 278 Query: 311 NCPVETLKEQSNPALAIKR 329 + + + A+ Sbjct: 279 SYADSRIVSKLGEAMGFSE 297 >4CFH-A nrPDB Length = 493 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 76/335 (22%), Positives = 126/335 (37%), Gaps = 34/335 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + Y D LG G F V + + T VA+K + + REI Sbjct: 27 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIR--SLDVVGKIRREI 84 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + L+ HP+II L S+I +V +++ + L + L Sbjct: 85 QNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILS 144 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 G++Y H+H ++HRDLKP N+LLD + K+ADFGL+ + S + Y APE+ Sbjct: 145 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEV 203 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G G VD+W+ G IL LL D +I + + Sbjct: 204 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY-----------T 252 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P Y+ ++ L++ + +P R T + ++F Sbjct: 253 PQYL-----------------NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYL 295 Query: 304 GCQLPRPNCPV---ETLKEQSNPALAIKRKRTEAL 335 + P + + E LKE + + L Sbjct: 296 FPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCL 330 >4CFF-A nrPDB Length = 571 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 118/318 (37%), Gaps = 34/318 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + Y D LG G F V + T VA+K + + REI Sbjct: 27 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR--SLDVVGKIKREI 84 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + L+ HP+II L ++ +V +++ + + L Sbjct: 85 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 144 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ + S + Y APE+ Sbjct: 145 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEV 203 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G G VD+W+ G IL LL D + + +F+ + + + Sbjct: 204 ISGRLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGG-------VFYI 252 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P+Y+ + L+ + +P R T + ++F P Sbjct: 253 PEYL-----------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD---LP 292 Query: 304 GCQLPRPNCPVETLKEQS 321 P + + Sbjct: 293 SYLFPEDPSYDANVIDDE 310 >3ZUT-A nrPDB Length = 362 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 80/328 (24%), Positives = 134/328 (40%), Gaps = 39/328 (11%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M L + + RYE + +G G F RDK +N++VA+K I+ G + I+ Sbjct: 10 MDLPIMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG------EKIDENVK 63 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 REI + L HPNI+ + +++++V ++ N+ + + + Sbjct: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDEN--GVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + G+ Y H + HRDLK N LLD + LK+ FG +KS + V T Y Sbjct: 124 LISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKS-SVLHSQPKSTVGTPAY 182 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+L G D+W+ G L +L+ PF + + I L Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL-------- 234 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-S 296 ++PDYV + LI +F+ +P RI+ + ++F Sbjct: 235 NVQYAIPDYVHI---------------SPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 Query: 297 NRP-----GPTPGCQLPRPNCPVETLKE 319 N P T Q + P ++++E Sbjct: 280 NLPADLMNDNTMTTQFDESDQPGQSIEE 307 >5EZV-A nrPDB Length = 560 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 118/318 (37%), Gaps = 34/318 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + Y D LG G F V + T VA+K + + REI Sbjct: 22 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR--SLDVVGKIKREI 79 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + L+ HP+II L ++ +V +++ + + L Sbjct: 80 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 139 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ + S + Y APE+ Sbjct: 140 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEV 198 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G G VD+W+ G IL LL D + + +F+ + + + Sbjct: 199 ISGRLYAGPEVDIWSCGVILYALLCGTLPF----DDEHVPTLFKKIRGG-------VFYI 247 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P+Y+ + L+ + +P R T + ++F P Sbjct: 248 PEYL-----------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD---LP 287 Query: 304 GCQLPRPNCPVETLKEQS 321 P + + Sbjct: 288 SYLFPEDPSYDANVIDDE 305 >4RED-A nrPDB Length = 351 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 124/332 (37%), Gaps = 34/332 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + Y D LG G F V + + T VA+K + + REI+ L Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIR--SLDVVGKIRREIQNL 68 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + HP+II L S+I +V +++ + L + L G++ Sbjct: 69 KLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 Y H+H ++HRDLKP N+LLD + K+ADFGL+ + S + Y APE++ G Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G VD+W+ G IL LL D +I + + P Y Sbjct: 188 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY-----------TPQY 236 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 + ++ L++ + +P R + + ++F + Sbjct: 237 L-----------------NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPE 279 Query: 307 LPRPNCPV---ETLKEQSNPALAIKRKRTEAL 335 P + + E LKE + + L Sbjct: 280 DPSYSTTMIDDEALKEVCEKFECSEEEVLSCL 311 >3MV5-A nrPDB Length = 342 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 70/332 (21%), Positives = 119/332 (35%), Gaps = 39/332 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A+D + +E L LG+G F V ++K T + A+K +K + + L Sbjct: 2 AMDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLT 59 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E ++LQ HP + L +F + V ++ V + + Y Sbjct: 60 ENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEI 119 Query: 122 LQGLEYLHQ-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + L+YLH +++RDLK NL+LD++G +K+ DFGL K T Y A Sbjct: 120 VSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLA 179 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI-FETLGTPTEEQWPD 239 PE+L YG VD W +G ++ E++ I E + P Sbjct: 180 PEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP------- 231 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKY 294 G + L+ GL +P R+ A + ++ ++ Sbjct: 232 ----------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 269 Query: 295 FSNRPGPTPGCQLPRPNCPVETLKEQSNPALA 326 F+ + P + E Sbjct: 270 FAGIVWQHVYEKKLSPPFKPQVTSETDTRYFD 301 >3I6U-A nrPDB Length = 419 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 82/300 (27%), Positives = 129/300 (43%), Gaps = 33/300 (11%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHR---SEAKDGINRTALRE 62 K+ Y LG G V A ++ T + VAI+ I S + E Sbjct: 131 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETE 190 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I++L++L+HP II + + F + +V + ME + L + K Y L Sbjct: 191 IEILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQML 249 Query: 123 QGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 ++YLH++ I+HRDLKP N+LL E+ ++K+ DFG +K G + T T Y Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYL 308 Query: 180 APELL--FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+L G Y VD W++G IL L P Sbjct: 309 APEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQ------------------ 350 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 SL D +T + IP +++ + LDL++ L + +P AR T +AL+ + + Sbjct: 351 ---VSLKDQITSGKYNFIP--EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >4CZT-A nrPDB Length = 464 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 80/334 (23%), Positives = 126/334 (37%), Gaps = 33/334 (9%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++R +YE LGEG FA V AR+ VAIK I K+ + REI Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV--LKNKMIAQIKREIST 64 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 ++ + HPN+I + + K+ I V +F+ ++ L + Y + + Sbjct: 65 MKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK--SFGSPNRAYTHQVVTRWYRAPEL 183 +Y H + HRDLKP NLLLD NG LK++DFGL+ + T Y APE+ Sbjct: 125 DYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEV 184 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G D+W+ G IL L+ + +IF+ Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA--------------- 229 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN-RPGPT 302 F P LI+ + NP RIT + ++ ++F P Sbjct: 230 -------EFTCPPWF------SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 276 Query: 303 PGCQLPRPNCPVETLKEQSNPALAIKRKRTEALE 336 + + + +R E L+ Sbjct: 277 FENADVSLDDVDAIFDDSGESKNLVVERREEGLK 310 >4RLP-A nrPDB Length = 288 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 130/317 (41%), Gaps = 39/317 (12%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 K R + +E L LG+G + V++ R NT +I A+K +K T E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA-E 59 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 +L+E+ HP I+ L+ AF + L+ +++ + + + Y+ Sbjct: 60 RNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS 119 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 L +LHQ I++RDLKP N++L+ G +KL DFGL K T Y APE Sbjct: 120 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE 179 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L + + VD W++G ++ ++L P G++ + +I + + Sbjct: 180 ILMRS-GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK-----------LN 227 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSN 297 LP Y+T + DL++ L N +R+ A + +F + Sbjct: 228 LPPYLT-----------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRH 270 Query: 298 RPGPTPGC-QLPRPNCP 313 ++ P P Sbjct: 271 INWEELLARKVEPPFKP 287 >2JAM-A nrPDB Length = 304 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 77/333 (23%), Positives = 131/333 (39%), Gaps = 39/333 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 ++ + K + ++ LG G F+ V+ + + T ++ A+K IK + + + Sbjct: 1 SMQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK-----SPAFRDSSLEN 55 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 EI +L+++ H NI+ L D + ++ LV + V T + Sbjct: 56 EIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQV 115 Query: 122 LQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L ++YLH++ I+HRDLKP NLL +EN + + DFGL+K N + T Y Sbjct: 116 LSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK--MEQNGIMSTACGTPGY 173 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE+L + Y VD W++G I LL P +++ +I E W Sbjct: 174 VAPEVL-AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWD 232 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF--- 295 D+ + D I L +P R T +AL + Sbjct: 233 DI------------------------SESAKDFICHLLEKDPNERYTCEKALSHPWIDGN 268 Query: 296 -SNRPGPTPGCQLPRPNCPVETLKEQSNPALAI 327 + P L ++ Q+ A A+ Sbjct: 269 TALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAV 301 >3UDB-A nrPDB Length = 317 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 81/328 (24%), Positives = 135/328 (41%), Gaps = 39/328 (11%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M L + + RYE + +G G F RDK N++VA+K I+ G + I+ Sbjct: 10 MDLPIMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG------EKIDENVK 63 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 REI + L HPNI+ + +++++V ++ N+ + + + Sbjct: 64 REIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQ 123 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDEN--GVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + G+ Y H + HRDLK N LLD + LK+ADFG +K+ + V T Y Sbjct: 124 LISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA-SVLHSQPKSAVGTPAY 182 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+L G D+W+ G L +L+ PF + + I L Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRIL-------- 234 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-S 296 ++PDYV + LI +F+ +P RI+ + ++F Sbjct: 235 NVQYAIPDYVHI---------------SPECRHLISRIFVADPAKRISIPEIRNHEWFLK 279 Query: 297 NRP-----GPTPGCQLPRPNCPVETLKE 319 N P T Q + P ++++E Sbjct: 280 NLPADLMNDNTMTTQFDESDQPGQSIEE 307 >2JDO-A nrPDB Length = 342 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 116/299 (38%), Gaps = 36/299 (12%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A+D K ++ L LG+G F V R+K T + A+K ++ + + + Sbjct: 2 AMDPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAH--TVT 59 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E ++LQ HP + L AF + V ++ V T + Y Sbjct: 60 ESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEI 119 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 + LEYLH +++RD+K NL+LD++G +K+ DFGL K S T Y AP Sbjct: 120 VSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAP 179 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 E+L YG VD W +G ++ E++ R+FE + Sbjct: 180 EVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELI------------ 222 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYF 295 + + L+ GL +P R+ A + ++ ++F Sbjct: 223 ------------LMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF 269 >2UV2-A nrPDB Length = 325 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 131/290 (45%), Gaps = 35/290 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG+G F VYKA++K T+ + A K I E +D + EI +L H Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDY-----MVEIDILASCDH 93 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 PNI+ LLDAF +++N+ ++ +F ++ ++ + LT S I+ TL L YLH Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA--- 187 + I+HRDLK N+L +G +KLADFG++ + + T ++ APE++ Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSK 213 Query: 188 -RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 R Y D+W++G L E+ P + + L +I ++ Sbjct: 214 DRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS------------------ 255 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 P S + D ++ N AR T +Q L+ + + Sbjct: 256 -------EPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVT 298 >5XZW-A nrPDB Length = 471 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 79/303 (26%), Positives = 135/303 (44%), Gaps = 44/303 (14%) Query: 10 KRYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 K + + + +G+G FATV KA ++ T + A+K I DG+ RE+++LQ+ Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT----RELEVLQK 250 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L+HP I+ L + + +V +F+ + + + L ++Y+ Sbjct: 251 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 310 Query: 129 HQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I HRDLKP+N+L++++ +K+ DFGLAK G+ + T T Y APE++ G Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKT-FCGTLAYVAPEVIRG 369 Query: 187 ARM------------YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 Y VDMW++GC++ +L G S DQL ++ +G + Sbjct: 370 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQDQL---YKQIGRGSY 425 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 + P L D+ ++ D I L +P R TA +AL + Sbjct: 426 HEGP----LKDF----------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPW 465 Query: 295 FSN 297 + Sbjct: 466 IVD 468 >6FD3-A nrPDB Length = 300 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 131/288 (45%), Gaps = 34/288 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K+Y + + +G+G TVY A D T Q VAIK++ L + + + EI +++E Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-----ELIINEILVMREN 76 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 +PNI+ LD++ + +V +++ L ++ + + I A LQ L++L Sbjct: 77 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFL 134 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H + ++HRD+K +N+LL +G +KL DFG + V T ++ APE++ + Sbjct: 135 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRK 193 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 YG VD+W++G + E++ P ++ L L I T GTP E Q P+ S Sbjct: 194 AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLI-ATNGTP-ELQNPERLSAV---- 247 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 D + + R +A + L+ + Sbjct: 248 -------------------FRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >2YAB-A nrPDB Length = 361 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 124/290 (42%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGI-NRTALREIKLLQELS 70 Y+ + LG GQFA V K R+K+T A K IK ++ G+ RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 HPNII L D + +++++ L+ + + L+ +++ L G+ YLH Sbjct: 74 HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 131 HWILHRDLKPNNLLLDENG----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I H DLKP N++L + +KL DFGLA + + T + APE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI-EDGVEFKNIFGTPEFVAPEIV-N 191 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G+ DMW++G I LL GD+ + L I EE Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEE----------- 240 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 FS + D I+ L + R+T +AL+ + + Sbjct: 241 -------------FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5KCV-A nrPDB Length = 460 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 68/328 (20%), Positives = 116/328 (35%), Gaps = 39/328 (11%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + +E L LG+G F V ++K T + A+K +K + + L E ++ Sbjct: 158 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH--TLTENRV 215 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 LQ HP + L +F + V ++ V + + Y + L Sbjct: 216 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSAL 275 Query: 126 EYLHQ-HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 +YLH +++RDLK NL+LD++G +K+ DFGL K T Y APE+L Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 335 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI-FETLGTPTEEQWPDMCSL 243 YG VD W +G ++ E++ I E + P Sbjct: 336 EDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP----------- 383 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNR 298 G + L+ GL +P R+ A + ++ ++F+ Sbjct: 384 ------------------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 425 Query: 299 PGPTPGCQLPRPNCPVETLKEQSNPALA 326 + P + E Sbjct: 426 VWQHVYEKKLSPPFKPQVTSETDTRYFD 453 >2YZA-A nrPDB Length = 276 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 110/295 (37%), Gaps = 31/295 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + Y D LG G F V + T VA+K + + REI Sbjct: 5 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR--SLDVVGKIKREI 62 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + L+ HP+II L ++ +V +++ + + L Sbjct: 63 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILS 122 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 ++Y H+H ++HRDLKP N+LLD + K+ADFGL+ + S + Y APE+ Sbjct: 123 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS-NMMSDGEFLRDSCGSPNYAAPEV 181 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G G VD+W+ G IL LL + +I + + Sbjct: 182 ISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY-----------I 230 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 P+Y+ + L+ + +P R T + ++F Sbjct: 231 PEYL-----------------NRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 268 >2HAK-A nrPDB Length = 328 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 72/318 (22%), Positives = 124/318 (38%), Gaps = 32/318 (10%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A D + Y +G+G FA V AR T + VA+K I + + R Sbjct: 7 ATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS---LQKLFR 63 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E+++++ L+HPNI+ L + + + LV ++ + +A Sbjct: 64 EVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 123 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 + ++Y HQ +I+HRDLK NLLLD + +K+ADFG + F N+ T + Y AP Sbjct: 124 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDT-FCGSPPYAAP 182 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL G + G VD+W++G IL L+ G + + R+ Sbjct: 183 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR---------- 232 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 +P Y++ + + + P R + Q +K ++ + Sbjct: 233 -IPFYMSTDCENLLKKLLVLN-----------------PIKRGSLEQIMKDRWMNVGHEE 274 Query: 302 TPGCQLPRPNCPVETLKE 319 P+ K Sbjct: 275 EELKPYTEPDPDFNDTKR 292 >6C9D-A nrPDB Length = 459 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 123/318 (38%), Gaps = 32/318 (10%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A D + Y +G+G FA V AR T + VA+K I + + R Sbjct: 13 ATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTS---LQKLFR 69 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E+++++ L+HPNI+ L + + + LV ++ + +A Sbjct: 70 EVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 129 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 + ++Y HQ +I+HRDLK NLLLD + +K+ADFG + F N+ + Y AP Sbjct: 130 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-LDEFCGSPPYAAP 188 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL G + G VD+W++G IL L+ G + + R+ Sbjct: 189 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR---------- 238 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 +P Y++ + + + P R + Q +K ++ + Sbjct: 239 -IPFYMSTDCENLLKKLLVLN-----------------PIKRGSLEQIMKDRWMNVGHEE 280 Query: 302 TPGCQLPRPNCPVETLKE 319 P+ K Sbjct: 281 EELKPYTEPDPDFNDTKR 298 >3DAK-A nrPDB Length = 290 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 80/309 (25%), Positives = 125/309 (40%), Gaps = 35/309 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 AL YE + +G G A V A + VAIK+I L + D L+ Sbjct: 2 ALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD----ELLK 57 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIK------DNSLVLTPSH 113 EI+ + + HPNI+ +F K + LV + L++I S VL S Sbjct: 58 EIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 117 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-----NRA 168 I + L+GLEYLH++ +HRD+K N+LL E+G +++ADFG++ + N+ Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 177 Query: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 V T + APE++ R Y D+W+ G EL + L + Sbjct: 178 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN 237 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 P+ E G+ + G +I +P R TA + Sbjct: 238 -DPPSLET-----------------GVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAE 279 Query: 289 ALKMKYFSN 297 L+ K+F Sbjct: 280 LLRHKFFQK 288 >4I6B-A nrPDB Length = 308 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 121/295 (41%), Gaps = 31/295 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + KRY + LG+G FA Y+ D N++ A K I H +K +EI+L Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIP--HSRVSKPHQREKIDKEIELH 82 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + L H +++ F K NI ++ ++ I VLT ++ Y+ + GL+ Sbjct: 83 RILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLK 142 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 YLH+ ILHRDLK N ++E+ LK+ DFGLA T Y +PE+L Sbjct: 143 YLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-N 201 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 + +G D+WA+GC++ +LL P + + I E T Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMP------------- 248 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 S+ LI + NP R + ++ +F+ P Sbjct: 249 ---------------SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTP 288 >3DB8-A nrPDB Length = 317 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 124/300 (41%), Gaps = 32/300 (10%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 +D ++ KRY + FLG+G FA Y+ D +T ++ A K + K E Sbjct: 36 VDPRT-MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVP--KSMLLKPHQKEKMSTE 92 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I + + L +P+++G F + +V + + + +T + +M T+ Sbjct: 93 IAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQTI 152 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 QG++YLH + ++HRDLK NL L+++ +K+ DFGLA T Y APE Sbjct: 153 QGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPE 212 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +L + + VD+W++GCIL LL+ P + RI Sbjct: 213 VL-CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI----------------- 254 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 + + LI+ + +P R + + L ++F++ P Sbjct: 255 -----------KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPM 303 >3GUB-A nrPDB Length = 295 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 77/290 (26%), Positives = 126/290 (43%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR-TALREIKLLQELS 70 Y+ + LG GQFA V K R+K+T A K IK ++ G++R RE+ +L+E+ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 HPN+I L + + +K+++ L+ + + LT ++ L G+ YLH Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS 132 Query: 131 HWILHRDLKPNNLLLDENGV----LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I H DLKP N++L + V +K+ DFGLA N + + T + APE++ Sbjct: 133 LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPEIV-N 190 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G+ DMW++G I LL GD+ + L + +E Sbjct: 191 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDE----------- 239 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 FS D I+ L + +P R+T +L+ + Sbjct: 240 -------------YFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >4D28-A nrPDB Length = 446 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 113/294 (38%), Gaps = 30/294 (10%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 R +YE +GEG FA V AR+ +T VAIK + + K+ + REI +++ Sbjct: 7 RVGKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM--AKSTILKNRMVDQIKREISIMK 64 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 + HPNI+ L + KS I +V +F+ + L + Y + + + Sbjct: 65 IVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAH 124 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 H + HRDLKP NLLLD NG LK++DFGL+ T Y APE+L G Sbjct: 125 CHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQ 184 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 G D+W+ G IL +L +I Sbjct: 185 GYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKI---------------------- 222 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 F P ++ LI + NP RI K +F P Sbjct: 223 NAAEFDCPPWF------SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVP 270 >3UTO-A nrPDB Length = 573 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 80/320 (25%), Positives = 134/320 (41%), Gaps = 36/320 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Y+ + LG G F V++ ++ T A K + H S+ T +EI+ + L Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK-----ETVRKEIQTMSVL 211 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HP ++ L DAF + + ++++FM L + D ++ YM +GL ++ Sbjct: 212 RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 129 HQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H++ +H DLKP N++ + LKL DFGL P ++ T + APE+ G Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPEVAEG 330 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 + G DMW+VG + LL + G++D + L + Sbjct: 331 -KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV--------------------- 368 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 KS FS +D D I+ L L +P R+T QAL+ + + PG PG Sbjct: 369 ---KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT--PGNAPGRD 423 Query: 307 LPRPNCPVETLKEQSNPALA 326 P+ +++ Sbjct: 424 SQIPSSRYTKIRDSIKTKYD 443 >6E9W-A nrPDB Length = 443 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 76/350 (21%), Positives = 134/350 (38%), Gaps = 37/350 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D++ +A+ YE + +G G F V R K+T ++ A+K + + D E Sbjct: 96 DLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSA--FFWEER 153 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 ++ + P ++ L AF + +V ++M V + N V + Y + Sbjct: 154 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVVL 212 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ-VVTRWYRAPE 182 L+ +H +HRD+KP+N+LLD++G LKLADFG V T Y +PE Sbjct: 213 ALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPE 272 Query: 183 LLF---GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 +L G YG D W+VG L E+L+ DS + ++I + Sbjct: 273 VLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN---------HKN 323 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALKMKYFS 296 + PD + + +LI + R+ + + +F Sbjct: 324 SLTFPD---------------DNDISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFK 367 Query: 297 NRPGP-TPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLI 345 N P P + ++ ++ + E E +PK + Sbjct: 368 NDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEE-ETFPIPKAFV 416 >4B6L-A nrPDB Length = 281 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 81/290 (27%), Positives = 115/290 (39%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y K LG+G FA Y+A D T A+K I AK L EI+L ++L H Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRV--AKPHQREKILNEIELHRDLQH 68 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 +I+ F NI + + I L ++ Y+ L GL+YLHQ Sbjct: 69 RHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR 128 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 ILHRDLK N + EN LK+ DFGLA P + T Y APE+L + +G Sbjct: 129 GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHG 187 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D+W++GC++ LL P + I + T P SLP Sbjct: 188 PEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYT-----LPASLSLP------- 235 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 L+ + +P R + Q L+ +F+ P Sbjct: 236 ----------------ARQLLAAILRASPRDRPSIDQILRHDFFTKGYTP 269 >2F57-A nrPDB Length = 317 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 71/293 (24%), Positives = 125/293 (42%), Gaps = 36/293 (12%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 +GEG V A +K+T + VA+KK+ L K E+ ++++ H N++ Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLR-----KQQRRELLFNEVVIMRDYHHDNVVD 106 Query: 77 LLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + ++ + +V +F+E L I+ + I L L+ L YLH ++H Sbjct: 107 MYSSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIATVCLSVLRALSYLHNQGVIH 164 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVD 195 RD+K +++LL +G +KL+DFG V T ++ APE++ YG VD Sbjct: 165 RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVD 223 Query: 196 MWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGI 255 +W++G ++ E++ P + L + RI ++L P + Sbjct: 224 IWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP----------------------PRV 261 Query: 256 PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 H S+ LDL + + P R TA + L + P C +P Sbjct: 262 KDLHKVSSVLRGFLDL---MLVREPSQRATAQELLGHPFLK--LAGPPSCIVP 309 >5D9K-A nrPDB Length = 330 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 123/304 (40%), Gaps = 42/304 (13%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 K+ ++E L LG+G F V+ + + Q+ A+K +K + E Sbjct: 26 KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM---E 82 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 +L E++HP I+ L AF + + L+ DF+ ++ T +K Y+ Sbjct: 83 RDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 L++LH I++RDLKP N+LLDE G +KL DFGL+K + T Y APE Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 202 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET-LGTPTEEQWPDMC 241 ++ R + D W+ G ++ E+L G + +T I + LG P Sbjct: 203 VV-NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF------- 254 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA-----TQALKMKYFS 296 + L++ LF NP R+ A + + +FS Sbjct: 255 ----------------------LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFS 292 Query: 297 NRPG 300 Sbjct: 293 TIDW 296 >5X8I-B nrPDB Length = 346 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 134/330 (40%), Gaps = 53/330 (16%) Query: 9 AKRYEKLDFLGEGQFATVYKAR-DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + RYE +D LGEG F V + K + VA+K +K D A EI++L+ Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK------NVDRYCEAARSEIQVLE 65 Query: 68 ELS--HPN----IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLM 120 L+ PN + +L+ F H +I +VF+ + IK+N HI+ Sbjct: 66 HLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQ 125 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDE-------------------NGVLKLADFGLAKS 161 + + +LH + + H DLKP N+L + N +K+ DFG A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY 185 Query: 162 FGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 + ++ V TR YRAPE++ + D+W++GCIL E L P + Sbjct: 186 ---DDEHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 222 LTRIFETLGTPT----------------EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG 265 L + LG W + S YV+ P Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 266 DDLLDLIQGLFLFNPCARITATQALKMKYF 295 + L DLIQ + ++P RIT +ALK +F Sbjct: 302 ERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >3HDN-A nrPDB Length = 373 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 112/299 (37%), Gaps = 34/299 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 + + ++ + L +G+G F V AR K A+K ++ + K+ + + R Sbjct: 30 SSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSER 89 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 + LL+ + HP ++GL +F + V D++ + Y Sbjct: 90 NV-LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 148 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 L YLH I++RDLKP N+LLD G + L DFGL K N + T Y AP Sbjct: 149 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 208 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 E+L + Y VD W +G +L E+L +P + + I Sbjct: 209 EVLH-KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN-------------- 253 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT----QALKMKYFS 296 + + L++GL + R+ A + +FS Sbjct: 254 --------------KPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFS 298 >2A27-A nrPDB Length = 321 Score = 247 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 125/290 (43%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQELS 70 Y+ + LG GQFA V K R+K+T A K IK ++ G++R RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 H N+I L D + +++++ L+ + + L+ +++ L G+ YLH Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 131 HWILHRDLKPNNLLLDENG----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I H DLKP N++L + +KL DFGLA + + T + APE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI-EDGVEFKNIFGTPEFVAPEIV-N 191 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G+ DMW++G I LL GD+ + L I EE Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEE----------- 240 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 FS + D I+ L + R+T +AL+ + + Sbjct: 241 -------------FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >1KOA-A nrPDB Length = 491 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 80/320 (25%), Positives = 134/320 (41%), Gaps = 36/320 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Y+ + LG G F V++ ++ T A K + H S+ T +EI+ + L Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK-----ETVRKEIQTMSVL 105 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HP ++ L DAF + + ++++FM L + D ++ YM +GL ++ Sbjct: 106 RHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 129 HQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H++ +H DLKP N++ + LKL DFGL P ++ T + APE+ G Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPEVAEG 224 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 + G DMW+VG + LL + G++D + L + Sbjct: 225 -KPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNV--------------------- 262 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 KS FS +D D I+ L L +P R+T QAL+ + + PG PG Sbjct: 263 ---KSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT--PGNAPGRD 317 Query: 307 LPRPNCPVETLKEQSNPALA 326 P+ +++ Sbjct: 318 SQIPSSRYTKIRDSIKTKYD 337 >2X4F-A nrPDB Length = 373 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 80/286 (27%), Positives = 132/286 (46%), Gaps = 34/286 (11%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG G+F V+K + T +A K IK + ++ N EI ++ +L H N+I Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN-----EISVMNQLDHANLI 149 Query: 76 GLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L DAF K++I LV ++++ L I D S LT +M +G+ ++HQ +IL Sbjct: 150 QLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYIL 209 Query: 135 HRDLKPNNLL-LDENG-VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGV 192 H DLKP N+L ++ + +K+ DFGLA+ + P T + APE++ Sbjct: 210 HLDLKPENILCVNRDAKQIKIIDFGLARRY-KPREKLKVNFGTPEFLAPEVV-NYDFVSF 267 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 DMW+VG I LL + GD+D + L I +E++ D+ Sbjct: 268 PTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDI------------ 315 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 ++ + I L + RI+A++ALK + S+ Sbjct: 316 ------------SEEAKEFISKLLIKEKSWRISASEALKHPWLSDH 349 >4QMW-A nrPDB Length = 310 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 122/293 (41%), Gaps = 34/293 (11%) Query: 4 DVKSRAKR-YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 ++K+ + + KL+ +G+G F V+K D T ++VAIK I L + + I + E Sbjct: 22 NLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQ----E 77 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I +L + P + ++ + + ++ +++ + + + L + I + L Sbjct: 78 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREIL 136 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +GL+YLH +HRD+K N+LL E+G +KLADFG+A V T ++ APE Sbjct: 137 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 196 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ + Y D+W++G EL P + L I Sbjct: 197 VIKQS-AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI----------------- 238 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 P + L + ++ P R TA + LK K+ Sbjct: 239 ----------PKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >5J5T-A nrPDB Length = 370 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 74/291 (25%), Positives = 122/291 (41%), Gaps = 30/291 (10%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + +E + +G G + VYKAR+ NT ++ AIK IKL + +EI ++++ Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFA-----VVQQEIIMMKDC 58 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HPNI+ ++ + + + +F I + L+ I TLQGL YLH Sbjct: 59 KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLH 118 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL--LFGA 187 +HRD+K N+LL +NG +KLADFG++ + + T ++ APE+ + Sbjct: 119 SKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERK 178 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 Y D+WAVG EL P + DL + +F + Sbjct: 179 GGYNQLCDLWAVGITAIELAELQPPMF---DLHPMRALF--------------------L 215 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 KS P + ++ NP R TA + L+ + + Sbjct: 216 MTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQH 266 >2XIK-A nrPDB Length = 294 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 72/292 (24%), Positives = 123/292 (42%), Gaps = 33/292 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + KLD +G+G F VYK D +T ++VAIK I L + + I + EI +L + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQ----EITVLSQCDS 76 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P I ++ + + ++ +++ + + L ++I + L+GL+YLH Sbjct: 77 PYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-PGPLEETYIATILREILKGLDYLHSE 135 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 +HRD+K N+LL E G +KLADFG+A V T ++ APE++ + Y Sbjct: 136 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS-AYD 194 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D+W++G EL P +SDL + +F Sbjct: 195 FKADIWSLGITAIELAKGEPP---NSDLHPMRVLF------------------------L 227 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P + + ++ +P R TA + LK K+ + T Sbjct: 228 IPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTS 279 >2W4O-A nrPDB Length = 349 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 83/299 (27%), Positives = 122/299 (40%), Gaps = 37/299 (12%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 + + + +E LG G + VY+ + K T + A+K +K K + Sbjct: 45 GSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLK-------KTVDKKIVRT 97 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 EI +L LSHPNII L + F + ISLV + + + + Sbjct: 98 EIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQI 157 Query: 122 LQGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L+ + YLH++ I+HRDLKP NLL + LK+ADFGL+K T Y Sbjct: 158 LEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSK-IVEHQVLMKTVCGTPGY 216 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+L G YG VDMW+VG I LL PF D RI W Sbjct: 217 CAPEILRGC-AYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWW 275 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 ++ + DL++ L + +P R+T QAL+ + + Sbjct: 276 DEV------------------------SLNAKDLVRKLIVLDPKKRLTTFQALQHPWVT 310 >6FYV-A nrPDB Length = 337 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 133/328 (40%), Gaps = 53/328 (16%) Query: 11 RYEKLDFLGEGQFATVYKARDKN-TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 RYE +D LGEG F V + D VA+K +K R A EI++L+ L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR------YREAARSEIQVLEHL 68 Query: 70 SH--PN----IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTL 122 + PN + +L+ F H ++ +VF+ + IK+NS HI+ Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDE-------------------NGVLKLADFGLAKSFG 163 Q + +LH + + H DLKP N+L + N +K+ DFG A Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY-- 186 Query: 164 SPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLT 223 + ++ V TR YRAPE++ + D+W++GCIL E L + L Sbjct: 187 -DDEHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA 244 Query: 224 RIFETLGTPTEE----------------QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDD 267 + LG + W + S YV + P + Sbjct: 245 MMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEK 304 Query: 268 LLDLIQGLFLFNPCARITATQALKMKYF 295 L DL++ + ++P RIT +AL+ +F Sbjct: 305 LFDLVRRMLEYDPTQRITLDEALQHPFF 332 >5F9E-A nrPDB Length = 353 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 76/315 (24%), Positives = 126/315 (40%), Gaps = 34/315 (10%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 +L +K + + +E LG+G F V+ A K TNQ AIK +K D + Sbjct: 11 SLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVV--LMDDDVECTMV 68 Query: 62 EIKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 E ++L HP + + F K N+ V +++ + + S Y Sbjct: 69 EKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAE 128 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 + GL++LH I++RDLK +N+LLD++G +K+ADFG+ K + T Y A Sbjct: 129 IILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIA 188 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE+L G + Y VD W+ G +L E+L+ G + + I + P +W + Sbjct: 189 PEILLGQK-YNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI--RMDNPFYPRWLE- 244 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT-QALKMKYFSNRP 299 + DL+ LF+ P R+ + F Sbjct: 245 -------------------------KEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN 279 Query: 300 GPT-PGCQLPRPNCP 313 ++ P P Sbjct: 280 WEELERKEIDPPFRP 294 >4FIE-A nrPDB Length = 423 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 126/307 (41%), Gaps = 39/307 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D +S + K +GEG V A +++ ++VA+KK+ L K E Sbjct: 147 GDPRSYLDNFIK---IGEGSTGIVCIATVRSSGKLVAVKKMDLR-----KQQRRELLFNE 198 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMT 121 + ++++ H N++ + +++ + +V +F+E L I+ + I A L Sbjct: 199 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAV 256 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 LQ L LH ++HRD+K +++LL +G +KL+DFG V T ++ AP Sbjct: 257 LQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 316 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+ YG VD+W++G ++ E++ P + L + I + L Sbjct: 317 ELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------ 363 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 P L + L + +P R TA + LK + + Sbjct: 364 -------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK--AG 408 Query: 302 TPGCQLP 308 P +P Sbjct: 409 PPASIVP 415 >5DBX-A nrPDB Length = 328 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 81/299 (27%), Positives = 125/299 (41%), Gaps = 35/299 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 YE + +G G A V A K + VAIK+I L + D L+EI+ + + SH Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD----ELLKEIQAMSQCSH 68 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-LEVIIK-------DNSLVLTPSHIKAYMLMTLQ 123 PN++ +F K + LV + + IIK + VL + I + L+ Sbjct: 69 PNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLE 128 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-----NRAYTHQVVTRWY 178 GL+YLH++ +HRDLK N+LL E+G +++ADFG++ + N+ V T + Sbjct: 129 GLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCW 188 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE++ R Y DMW+ G EL + L + PT E Sbjct: 189 MAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQN-DPPTLET-- 245 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 G+ + G L+ +P R TA + LK K+F Sbjct: 246 ---------------GVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQK 289 >2Z7Q-A nrPDB Length = 321 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 124/308 (40%), Gaps = 42/308 (13%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRT 58 A K+ +E L LG+G F V+ R ++ + A+K +K + Sbjct: 20 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM 79 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYM 118 E +L +++HP ++ L AF + + L+ DF+ ++ T +K Y+ Sbjct: 80 ---ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 136 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 GL++LH I++RDLKP N+LLDE G +KL DFGL+K + T Y Sbjct: 137 AELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEY 196 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET-LGTPTEEQW 237 APE++ + + D W+ G ++ E+L G + +T I + LG P Sbjct: 197 MAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF--- 252 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKM 292 + L++ LF NP R+ A + + Sbjct: 253 --------------------------LSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRH 286 Query: 293 KYFSNRPG 300 ++S Sbjct: 287 VFYSTIDW 294 >4CRL-A nrPDB Length = 406 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 122/342 (35%), Positives = 165/342 (48%), Gaps = 50/342 (14%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQI--VAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 YE G G + VYKA+ K+ A+K+I GI+ +A REI LL+E Sbjct: 24 EYEGCKV-GRGTYGHVYKAKRKDGKDDKDYALKQI-------EGTGISMSACREIALLRE 75 Query: 69 LSHPNIIGLLDAFGH--KSNISLVFDFMETDLEVIIK--------DNSLVLTPSHIKAYM 118 L HPN+I L F + L+FD+ E DL IIK + L +K+ + Sbjct: 76 LKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLL 135 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQ-- 172 L G+ YLH +W+LHRDLKP N+L+ E G +K+AD G A+ F SP + Sbjct: 136 YQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP 195 Query: 173 -VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDL---------DQL 222 VVT WYRAPELL GAR Y +D+WA+GCI AELL P + DQL Sbjct: 196 VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQL 255 Query: 223 TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS----------AAGDDLLDLI 272 RIF +G P ++ W D+ +P++ T + S L+ Sbjct: 256 DRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLL 315 Query: 273 QGLFLFNPCARITATQALKMKYFSNRPGPTP----GCQLPRP 310 Q L +P RIT+ QA++ YF P PT GCQ+P P Sbjct: 316 QKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYP 357 >4KS7-A nrPDB Length = 292 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 124/293 (42%), Gaps = 36/293 (12%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 +GEG V AR+K++ + VA+K + L K E+ ++++ H N++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLR-----KQQRRELLFNEVVIMRDYQHFNVVE 84 Query: 77 LLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + ++ + ++ +F++ L I+ + L I LQ L YLH ++H Sbjct: 85 MYKSYLVGEELWVLMEFLQGGALTDIVSQ--VRLNEEQIATVCEAVLQALAYLHAQGVIH 142 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVD 195 RD+K +++LL +G +KL+DFG V T ++ APE++ + +Y VD Sbjct: 143 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS-LYATEVD 201 Query: 196 MWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGI 255 +W++G ++ E++ P DS + + R+ ++ Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDS-------------------------PP 236 Query: 256 PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 P L D ++ + + +P R TA + L + P C +P Sbjct: 237 PKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQT--GLPECLVP 287 >1ZWS-A nrPDB Length = 288 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 125/290 (43%), Gaps = 31/290 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQELS 70 Y+ + LG GQFA V K R+K+T A K IK ++ G++R RE+ +L+++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 H N+I L D + +++++ L+ + + L+ +++ L G+ YLH Sbjct: 74 HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHT 133 Query: 131 HWILHRDLKPNNLLLDENG----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 I H DLKP N++L + +KL DFGLA + + T + APE++ Sbjct: 134 KKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI-EDGVEFKNIFGTPEFVAPEIV-N 191 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 G+ DMW++G I LL GD+ + L I EE Sbjct: 192 YEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEE----------- 240 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 FS + D I+ L + R+T +AL+ + + Sbjct: 241 -------------FFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >4XBR-A nrPDB Length = 366 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 126/307 (41%), Gaps = 39/307 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D +S + K +GEG V A +++ ++VA+KK+ L K E Sbjct: 90 GDPRSYLDNFIK---IGEGSTGIVCIATVRSSGKLVAVKKMDLR-----KQQRRELLFNE 141 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMT 121 + ++++ H N++ + +++ + +V +F+E L I+ + I A L Sbjct: 142 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAV 199 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 LQ L LH ++HRD+K +++LL +G +KL+DFG V T ++ AP Sbjct: 200 LQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 259 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+ YG VD+W++G ++ E++ P + L + I + L Sbjct: 260 ELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------ 306 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 P L + L + +P R TA + LK + + Sbjct: 307 -------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK--AG 351 Query: 302 TPGCQLP 308 P +P Sbjct: 352 PPASIVP 358 >4CSV-A nrPDB Length = 275 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 119/292 (40%), Gaps = 42/292 (14%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + LG GQF VY+ + +N N VA+K +K G S L+E ++ Sbjct: 7 EIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS------VEEFLQEAQI 60 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDN-SLVLTPSHIKAYMLMTLQ 123 +++L HPN++ L + I ++ ++M L ++D + + Sbjct: 61 MKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVAS 120 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRA 180 G+ YL +HRDL N L+ EN V+K+ADFGLA+ YT + ++ + A Sbjct: 121 GMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINED--EYTARAGAKFPIKWTA 178 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 PE + R + + D+WA G +L E+ PG S + + ++ P + P Sbjct: 179 PEAISYNR-FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP- 236 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 +++ +L+ + +P R T + L Sbjct: 237 --------------------------EEIYELMLQCWNKSPEERPTFAETLH 262 >4JDH-A nrPDB Length = 346 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 126/307 (41%), Gaps = 39/307 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D +S + K +GEG V A +++ ++VA+KK+ L K E Sbjct: 70 GDPRSYLDNFIK---IGEGSTGIVCIATVRSSGKLVAVKKMDLR-----KQQRRELLFNE 121 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMT 121 + ++++ H N++ + +++ + +V +F+E L I+ + I A L Sbjct: 122 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAV 179 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 LQ L LH ++HRD+K +++LL +G +KL+DFG V T ++ AP Sbjct: 180 LQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 239 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+ YG VD+W++G ++ E++ P + L + I + L Sbjct: 240 ELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------ 286 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 P L + L + +P R TA + LK + + Sbjct: 287 -------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK--AG 331 Query: 302 TPGCQLP 308 P +P Sbjct: 332 PPASIVP 338 >2Q0N-A nrPDB Length = 301 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 126/307 (41%), Gaps = 39/307 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D +S + K +GEG V A +++ ++VA+KK+ L K E Sbjct: 25 GDPRSYLDNFIK---IGEGSTGIVCIATVRSSGKLVAVKKMDLR-----KQQRRELLFNE 76 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMT 121 + ++++ H N++ + +++ + +V +F+E L I+ + I A L Sbjct: 77 VVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAV 134 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 LQ L LH ++HRD+K +++LL +G +KL+DFG V T ++ AP Sbjct: 135 LQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAP 194 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+ YG VD+W++G ++ E++ P + L + I + L Sbjct: 195 ELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------ 241 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 P L + L + +P R TA + LK + + Sbjct: 242 -------------PPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK--AG 286 Query: 302 TPGCQLP 308 P +P Sbjct: 287 PPASIVP 293 >4PDS-A nrPDB Length = 347 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 134/305 (43%), Gaps = 44/305 (14%) Query: 10 KRYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 K + + + +G+G FATV KA ++ T + ++K I DG+ RE+++LQ+ Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVT----RELEVLQK 85 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L+HP I+ L + + +V +F+ + + + L ++Y+ Sbjct: 86 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 129 HQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I HRDLKP+N+L++++ +K+ FGLAK G+ + T T Y APE++ G Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKT-FCGTLAYVAPEVIRG 204 Query: 187 ARM------------YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 Y VDMW++GC++ +L G S DQL ++ +G + Sbjct: 205 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG-STQDQL---YKQIGRGSY 260 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 + P L D+ ++ D I L +P R TA +AL + Sbjct: 261 HEGP----LKDF----------------RISEEARDFIDSLLQVDPNNRSTAAKALNHPW 300 Query: 295 FSNRP 299 P Sbjct: 301 IKMSP 305 >6CMJ-A nrPDB Length = 321 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 77/309 (24%), Positives = 139/309 (44%), Gaps = 42/309 (13%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEA------KDGINRTAL 60 + +Y D +G+G + V A ++N N A+K + G Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 61 REIKLLQELSHPNIIGLLDAFGH--KSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAY 117 +EI +L++L HPN++ L++ + ++ +VF+ + +++ +L L+ + Y Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVPTLKPLSEDQARFY 148 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 ++G+EYLH I+HRD+KP+NLL+ E+G +K+ADFG++ F + ++ V T Sbjct: 149 FQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPA 208 Query: 178 YRAPELLFGARMY--GVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTE 234 + APE L R G +D+WA+G L + PF+ +++ + + + Sbjct: 209 FMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD-----ERIMCLHSKIKSQAL 263 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 E FP P +DL DLI + NP +RI + + Sbjct: 264 E----------------FPDQPD------IAEDLKDLITRMLDKNPESRIVVPEIKLHPW 301 Query: 295 FSNRPGPTP 303 + R G P Sbjct: 302 VT-RHGAEP 309 >6HXF-B nrPDB Length = 302 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 73/291 (25%), Positives = 125/291 (42%), Gaps = 35/291 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG+G F VYKA++K T + A K I+ E +D I EI++L H Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-----EIEILATCDH 75 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P I+ LL A+ H + ++ +F ++ I+ + LT I+ L+ L +LH Sbjct: 76 PYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA--- 187 I+HRDLK N+L+ G ++LADFG++ + + T ++ APE++ Sbjct: 136 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 195 Query: 188 -RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 Y D+W++G L E+ P + + L +I ++ Sbjct: 196 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS------------------ 237 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 P S + D ++ NP R +A Q L+ + S+ Sbjct: 238 -------DPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSS 281 >3Q53-A nrPDB Length = 306 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 69/288 (23%), Positives = 131/288 (45%), Gaps = 34/288 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K+Y + + +G+G TVY A D T Q VAI+++ L + + + EI +++E Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK-----ELIINEILVMREN 75 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 +PNI+ LD++ + +V +++ L ++ + + I A LQ LE+L Sbjct: 76 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALEFL 133 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H + ++HRD+K +N+LL +G +KL DFG + V T ++ APE++ + Sbjct: 134 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRK 192 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 YG VD+W++G + E++ P ++ L L I T GTP + + ++ Sbjct: 193 AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI-ATNGTPELQNPEKLSAI----- 246 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 D + + R +A + ++ ++ Sbjct: 247 -------------------FRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >4CQG-A nrPDB Length = 331 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 78/333 (23%), Positives = 120/333 (36%), Gaps = 36/333 (10%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D K YE + +G G FA V A T ++VAIK + A E Sbjct: 2 KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKN----ALGSDLPRVKTE 57 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I L+ L H +I L K+ I +V ++ + L+ + L Sbjct: 58 IDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIL 117 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGL-AKSFGSPNRAYTHQVVTRWYRAP 181 + Y+H HRDLKP NLL DEN LKL DFGL AK G+ + + Y AP Sbjct: 118 SAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAP 177 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+ G G D+W++G +L L+ D+ + +I Sbjct: 178 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKY----------- 226 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 +P ++ + L+Q + +P RI+ L + Sbjct: 227 EVPKWL-----------------SPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSC 269 Query: 302 TPGCQLPRPNCPVETLKEQSNPALAIKRKRTEA 334 Q P+ L E L++ + + Sbjct: 270 PVEWQS---KTPLTHLDEDCVTELSVHHRSSRQ 299 >5D7A-A nrPDB Length = 308 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 119/312 (38%), Gaps = 45/312 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ A +E ++ +G G + VYK R T Q+ AIK + + E +EI Sbjct: 12 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE------EEIKQEIN 65 Query: 65 LLQELSHP-NIIGLLDAFGHKSN------ISLVFDFMETDL--EVIIKDNSLVLTPSHIK 115 +L++ SH NI AF K+ + LV +F ++I L I Sbjct: 66 MLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIA 125 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVT 175 L+GL +LHQH ++HRD+K N+LL EN +KL DFG++ + T Sbjct: 126 YICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGT 185 Query: 176 RWYRAPELLFGARM----YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 ++ APE++ Y D+W++G E+ P L D+ + +F Sbjct: 186 PYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLC---DMHPMRALFLIPRN 242 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 P F + I+ + N R Q +K Sbjct: 243 PAP----------------RLKSKKWSKKFQS-------FIESCLVKNHSQRPATEQLMK 279 Query: 292 MKYFSNRPGPTP 303 + ++P Sbjct: 280 HPFIRDQPNERQ 291 >3TXO-A nrPDB Length = 353 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 78/341 (22%), Positives = 125/341 (36%), Gaps = 39/341 (11%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + +E + LG+G F V AR K T + A+K +K +D + E ++ Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVI--LQDDDVECTMTEKRI 76 Query: 66 LQEL-SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L +HP + L F + V +F+ + S + + Y + Sbjct: 77 LSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISA 136 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 L +LH I++RDLK +N+LLD G KLADFG+ K T Y APE+L Sbjct: 137 LMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 +YG VD WA+G +L E+L +++ D I D P Sbjct: 197 Q-EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN-----------DEVVYP 244 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-TATQ-----ALKMKYFSNR 298 ++ +D +++ NP R+ + TQ L+ +F Sbjct: 245 TWL-----------------HEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEI 287 Query: 299 PGPTPG-CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQG 338 Q+ P P +E + K L Sbjct: 288 DWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPI 328 >1FOT-A nrPDB Length = 318 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 73/333 (21%), Positives = 126/333 (37%), Gaps = 43/333 (12%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 K + ++ L LG G F V+ R ++ + A+K +K K + E + Sbjct: 2 KYSLQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTN--DERLM 59 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L ++HP II + F I ++ D++E + S K Y L Sbjct: 60 LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLAL 119 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 EYLH I++RDLKP N+LLD+NG +K+ DFG AK P+ YT T Y APE++ Sbjct: 120 EYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV--PDVTYT-LCGTPDYIAPEVV- 175 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + Y +D W+ G ++ E+L + + +I E ++P Sbjct: 176 STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILN-----AELRFP------- 223 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPG 300 +D+ DL+ L + R+ +F Sbjct: 224 ----------------PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVW 267 Query: 301 P---TPGCQLPRPNCPVETLKEQSNPALAIKRK 330 + + P P++ + ++ + Sbjct: 268 EKLLSRNIETPY-EPPIQQGQGDTSQFDKYPEE 299 >3IS5-A nrPDB Length = 285 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 116/293 (39%), Gaps = 39/293 (13%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + LG G F V+ ++++ IK I + I EI++L+ L H Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA----EIEVLKSLDH 79 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD--LEVII--KDNSLVLTPSHIKAYMLMTLQGLEY 127 PNII + + F N+ +V + E LE I+ + L+ ++ M + L Y Sbjct: 80 PNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAY 139 Query: 128 LHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 H ++H+DLKP N+L + + +K+ DFGLA+ F S + T+ T Y APE+ Sbjct: 140 FHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS-TNAAGTALYMAPEVF 198 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 R D+W+ G ++ LL G S + + Sbjct: 199 --KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQK-------------------- 236 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 ++ +DL++ + +P R +A Q L ++F Sbjct: 237 -----ATYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4FZF-B nrPDB Length = 283 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 115/292 (39%), Gaps = 33/292 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + KL+ +G+G F V+K D T Q+VAIK I L + + I + EI +L + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQ----EITVLSQCDS 65 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 + ++ S + ++ +++ + + I + L+GL+YLH Sbjct: 66 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAG-PFDEFQIATMLKEILKGLDYLHSE 124 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 +HRD+K N+LL E G +KLA FG+A V T ++ APE++ + Y Sbjct: 125 KKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS-AYD 183 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D+W++G EL P +SD+ + +F Sbjct: 184 SKADIWSLGITAIELAKGEPP---NSDMHPMRVLF------------------------L 216 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 P + + I +P R TA + LK K+ T Sbjct: 217 IPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTS 268 >6O6Q-A nrPDB Length = 335 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 148/299 (49%), Gaps = 25/299 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + YE L LG G+++ V+ D + V IK +K R + REI +L+ L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKR--------KKIKREISILKNL 92 Query: 70 -SHPNIIGLLDAFGHKSN--ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 PNII +LD + L+F+ + + + T I+ YM L+ L+ Sbjct: 93 VDGPNIIAMLDVVREPQSKTPGLIFEHINN---IDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 127 YLHQHWILHRDLKPNNLLLDENGV-LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y H I+HRD+KP+N+++D + L+L D+GLA + P Y +V +R+++ PELL Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLV 208 Query: 186 GARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL- 243 R+Y +DMW+ GC+LA + ++ PF G S+ DQL +I LG+ +++ + ++ Sbjct: 209 DYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNIS 268 Query: 244 --PDYVTFKSFPGIPLHHIFSA-----AGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 +Y + + + LDLI L ++ R+TA +A+K YF Sbjct: 269 LGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >6ED6-A nrPDB Length = 415 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 76/349 (21%), Positives = 134/349 (38%), Gaps = 37/349 (10%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ +A+ Y+ + +G G F V R K + ++ A+K + + D E Sbjct: 83 LQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSA--FFWEERD 140 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 ++ + P ++ L AF + +V ++M V + N V K Y + Sbjct: 141 IMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVVLA 199 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ-VVTRWYRAPEL 183 L+ +H ++HRD+KP+N+LLD++G LKLADFG + V T Y +PE+ Sbjct: 200 LDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEV 259 Query: 184 LF---GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 L G YG D W+VG L E+L+ DS + ++I Sbjct: 260 LKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM-------------- 305 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALKMKYFSN 297 D+ FP + +LI + R+ + + +F N Sbjct: 306 ----DHKNSLCFPE------DAEISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFFKN 354 Query: 298 RPGPTPGC-QLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLI 345 + P P + S+ I+ + + E +PK + Sbjct: 355 DQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDV-ETFPIPKAFV 402 >5JZN-A nrPDB Length = 280 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 123/295 (41%), Gaps = 34/295 (11%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + +RY+ +G+G FA V + +++T + A+K IK G E+ +L Sbjct: 16 TITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCR----GKEHMIQNEVSIL 71 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + + HPNI+ L++ + + LV + ++ ++ T + ++ Sbjct: 72 RRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIK 131 Query: 127 YLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 YLH I+HRD+KP NLL+ D + LKL DFGLA P T Y APE Sbjct: 132 YLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP---LYTVCGTPTYVAPE 188 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 ++ YG+ VD+WA G I LL P G D ++ +F+ + Sbjct: 189 IIAET-GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV--LFDQILMGQV-------- 237 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 FP D +LI + L + R +A Q L+ + ++ Sbjct: 238 --------DFPSPYW----DNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >3FXW-A nrPDB Length = 336 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 80/340 (23%), Positives = 128/340 (37%), Gaps = 49/340 (14%) Query: 7 SRAKRYEK-LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + Y+ LG G V + + T Q A+K + ++ + + A Sbjct: 25 AVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQAS----- 79 Query: 66 LQELSHPNIIGLLDAFGHKSN----ISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYML 119 P+I+ +LD + + + + ++ + ME I + T M Sbjct: 80 ----GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMR 135 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 +++LH H I HRD+KP NLL ++ VLKL DFG AK + A T Sbjct: 136 DIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTP 193 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 +Y APE+L G Y DMW++G I+ LL P ++ G Sbjct: 194 YYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT------------GQAISPG 240 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 L Y FP S +D LI+ L +P R+T TQ + + + Sbjct: 241 MKRRIRLGQY----GFPNPEW----SEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 292 Query: 297 NRPGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 +P+ P L+E + +K + T AL Sbjct: 293 Q------SMVVPQTPLHTARVLQEDKDHWDEVKEEMTSAL 326 >5DYK-A nrPDB Length = 853 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 96/331 (29%), Positives = 135/331 (40%), Gaps = 38/331 (11%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D K E +G G F TV K T A+K + N REI Sbjct: 533 DTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREI 592 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 E HP II L+ F + + + +L+ S + Y+ + Sbjct: 593 T--AENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIIL 650 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 +EYLH+ I++RDLKP N+LLD+ G +KL DFG AK RAYT V T Y APE+ Sbjct: 651 AIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ--GRAYT-LVGTPHYMAPEV 707 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G + YG VD+WA+G L E + P G+ + DQL IF + T + Sbjct: 708 ILG-KGYGCTVDIWALGICLYEFICG-PLPFGNDEEDQL-EIFRDILTG-------QLTF 757 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA-----TQALKMKYFSNR 298 PDYVT D ++L++ L P RI +FSN Sbjct: 758 PDYVT----------------DTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNF 801 Query: 299 PGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 +L P P+ + E + IK+ Sbjct: 802 NWDKLAGRLLDP--PLVSKSETYAEDIDIKQ 830 >2OU7-A nrPDB Length = 335 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 115/286 (40%), Gaps = 31/286 (10%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 FLG+G FA ++ D +T ++ A K + + EI + + L+H +++G Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQ--REKMSMEISIHRSLAHQHVVG 105 Query: 77 LLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 F + +V + + + LT + Y+ + G +YLH++ ++HR Sbjct: 106 FHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDM 196 DLK NL L+E+ +K+ DFGLA T Y APE+L + + VD+ Sbjct: 166 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDV 224 Query: 197 WAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIP 256 W++GCI+ LL+ P + RI Sbjct: 225 WSIGCIMYTLLVGKPPFETSCLKETYLRI----------------------------KKN 256 Query: 257 LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 + I LIQ + +P AR T + L ++F++ P Sbjct: 257 EYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPA 302 >1VZO-A nrPDB Length = 355 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 129/321 (40%), Gaps = 37/321 (11%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARD---KNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 K + +E L LG G + V+ R +T ++ A+K +K + T E Sbjct: 50 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHT-RTE 108 Query: 63 IKLLQELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++L+ + P ++ L AF ++ + L+ D++ T ++ Y+ Sbjct: 109 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 168 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT-HQVVTRWYRA 180 + LE+LH+ I++RD+K N+LLD NG + L DFGL+K F + T Y A Sbjct: 169 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMA 228 Query: 181 PELLFGAR-MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 P+++ G + VD W++G ++ ELL D + + I + Sbjct: 229 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI---------- 278 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKY 294 KS P P DLIQ L + +P R+ A + + + Sbjct: 279 ---------LKSEPPYP-----QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 324 Query: 295 FSNRPGPT-PGCQLPRPNCPV 314 F ++P P PV Sbjct: 325 FQKINWDDLAAKKVPAPFKPV 345 >4J52-A nrPDB Length = 293 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 115/286 (40%), Gaps = 31/286 (10%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 FLG+G FA ++ D +T ++ A K + + EI + + L+H +++G Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQ--REKMSMEISIHRSLAHQHVVG 78 Query: 77 LLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 F + +V + + + LT + Y+ + G +YLH++ ++HR Sbjct: 79 FHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 137 DLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDM 196 DLK NL L+E+ +K+ DFGLA T Y APE+L + + VD+ Sbjct: 139 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDV 197 Query: 197 WAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIP 256 W++GCI+ LL+ P + RI Sbjct: 198 WSIGCIMYTLLVGKPPFETSCLKETYLRI----------------------------KKN 229 Query: 257 LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 + I LIQ + +P AR T + L ++F++ P Sbjct: 230 EYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPA 275 >4APC-A nrPDB Length = 350 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 74/340 (21%), Positives = 135/340 (39%), Gaps = 33/340 (9%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 ++Y +L +GEG F + + IK+I + S + +R RE+ +L Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESR---REVAVLA 78 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 + HPNI+ ++F ++ +V D+ E + I ++ I + + L Sbjct: 79 NMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLAL 138 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 +++H ILHRD+K N+ L ++G ++L DFG+A+ S + T +Y +PE + Sbjct: 139 KHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPE-IC 197 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + Y D+WA+GC+L EL S + + +I P + Sbjct: 198 ENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHY-------- 249 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGC 305 DL L+ LF NP R + L+ + + R Sbjct: 250 -------------------SYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSP 290 Query: 306 QLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLI 345 QL ++T + + + KR + +P + I Sbjct: 291 QLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKI 330 >5FET-A nrPDB Length = 847 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 96/343 (27%), Positives = 138/343 (40%), Gaps = 38/343 (11%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D K E +G G F TV K T A+K + N REI Sbjct: 527 DTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREI 586 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 E HP II L+ F + + + + +L+ + Y+ + Sbjct: 587 T--AENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIIL 644 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 +EYLH+ I++RDLKP N+LLD+ G +KL DFG AK RAYT V T Y APE+ Sbjct: 645 AIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ--GRAYT-LVGTPHYMAPEV 701 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + G + YG VD+WA+G L E + P G+ DQL IF + T + Sbjct: 702 ILG-KGYGCTVDIWALGVCLYEFICG-PLPFGNDQEDQL-EIFRDILTG-------QLTF 751 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA-----TQALKMKYFSNR 298 PDYV+ + D ++L++ L P RI + +F N Sbjct: 752 PDYVSDQ----------------DSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNF 795 Query: 299 PGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLP 341 +L P P+ + E + IK+ E G P Sbjct: 796 NWDKLAGRLLEP--PLVSKGETYAEDIDIKQIEEEDALNEGEP 836 >6FDY-U nrPDB Length = 276 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 82/298 (27%), Positives = 123/298 (41%), Gaps = 33/298 (11%) Query: 8 RAKRYEKLDFLGEGQFATVYKAR-DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 R + + LG G +ATVYKA K+T ++VAIK + ++A L EI++L Sbjct: 9 RLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKAS---VENLLTEIEIL 65 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + + HP+I+ L D NI L+ +F +L + +M L+ Sbjct: 66 KGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 127 YLHQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 +LH+ I H DLKP N+LL E LKLADFG A+ + + + + Y APE++ Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR-GSPLYMAPEMV 184 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 R Y VD+W++G IL E L P S + +I Sbjct: 185 -CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI------------------- 224 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPT 302 P PL D DL+Q L +P RI+ + P+ Sbjct: 225 RSNRVIELPLRPL------LSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPS 276 >5YV8-A nrPDB Length = 298 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 136/318 (42%), Gaps = 56/318 (17%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEA--------------- 51 + +Y D +G+G + V A ++N N A+K + Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 52 ------KDGINRTALREIKLLQELSHPNIIGLLDAFGH--KSNISLVFDFMETDLEVIIK 103 G +EI +L++L HPN++ L++ + ++ +VF+ + +++ Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVME 127 Query: 104 DNSL-VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF 162 +L L+ + Y ++G+EYLH I+HRD+KP+NLL+ E+G +K+ADFG++ F Sbjct: 128 VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEF 187 Query: 163 GSPNRAYTHQVVTRWYRAPELLFGARMY--GVGVDMWAVGCILAELLLR-VPFLPGDSDL 219 + ++ V T + APE L R G +D+WA+G L + PF+ Sbjct: 188 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD----- 242 Query: 220 DQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN 279 +++ + + + E FP P +DL DLI + N Sbjct: 243 ERIMCLHSKIKSQALE----------------FPDQPD------IAEDLKDLITRMLDKN 280 Query: 280 PCARITATQALKMKYFSN 297 P +RI + + + Sbjct: 281 PESRIVVPEIKLHPWVTR 298 >1KOB-A nrPDB Length = 387 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 123/296 (41%), Gaps = 34/296 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y+ L+ LG G F V++ +K T ++ K I + + T EI ++ +L H Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDK-----YTVKNEISIMNQLHH 107 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 P +I L DAF K + L+ +F+ L I ++ + + YM +GL+++H+ Sbjct: 108 PKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHE 167 Query: 131 HWILHRDLKPNNLLL--DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H I+H D+KP N++ + +K+ DFGLA P+ T + APE++ Sbjct: 168 HSIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEIV-DRE 225 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 G DMWA+G + LL + G+ DL+ L + E+ Sbjct: 226 PVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDA------------ 273 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304 FS+ + D I+ L P R+T AL+ + Sbjct: 274 ------------FSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTS 317 >1NY3-A nrPDB Length = 400 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 81/338 (23%), Positives = 131/338 (38%), Gaps = 50/338 (14%) Query: 10 KRYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL-Q 67 Y+ LG G V + +K T + A+K ++ + A RE++L + Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----------ARREVELHWR 110 Query: 68 ELSHPNIIGLLDAFGH----KSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 P+I+ ++D + + + + +V + ++ I T M Sbjct: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + ++YLH I HRD+KP NLL N +LKL DFG AK S N + T T +Y Sbjct: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYY 229 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE+L G Y DMW++G I+ LL P + L + + E Sbjct: 230 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE--- 285 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP S +++ LI+ L P R+T T+ + + Sbjct: 286 -------------FPNPEW----SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ- 327 Query: 299 PGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 ++P+ P LKE +K + T AL Sbjct: 328 -----STKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 >5N23-A nrPDB Length = 352 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 116/310 (37%), Gaps = 39/310 (12%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++E++ LG G F V + K T A+K + + K L E ++ Q + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI--EHTLNEKRIQQAV 99 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + P ++ L +F SN+ +V ++ + H + Y + EYLH Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 +++RDLKP NLL+D+ G +K+ADFG AK R T Y APE++ ++ Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK--GRTPWTLCGTPEYLAPEIIL-SKG 216 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y VD WA+G ++ E+ P D + +I Sbjct: 217 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP---------------- 260 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGPTP- 303 S DL DL++ L + R K+F+ Sbjct: 261 ------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIY 308 Query: 304 GCQLPRPNCP 313 ++ P P Sbjct: 309 QRKVEAPFIP 318 >3KA0-A nrPDB Length = 320 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 81/338 (23%), Positives = 131/338 (38%), Gaps = 50/338 (14%) Query: 10 KRYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL-Q 67 Y+ LG G V + +K T + A+K ++ + A RE++L + Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----------ARREVELHWR 64 Query: 68 ELSHPNIIGLLDAFGH----KSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 P+I+ ++D + + + + +V + ++ I T M Sbjct: 65 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 124 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + ++YLH I HRD+KP NLL N +LKL DFG AK S N + T T +Y Sbjct: 125 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTEPCYTPYY 183 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE+L G Y DMW++G I+ LL P + L + + E Sbjct: 184 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE--- 239 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP S +++ LI+ L P R+T T+ + + Sbjct: 240 -------------FPNPEW----SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ- 281 Query: 299 PGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 ++P+ P LKE +K + T AL Sbjct: 282 -----STKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 314 >3HKO-A nrPDB Length = 345 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 79/338 (23%), Positives = 119/338 (35%), Gaps = 71/338 (21%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K+Y +G+G + V A + T I AIK + + E++L+++L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD-----LEVIIKDN------------------- 105 HPNI L + + + I LV + L V I D+ Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 106 ----------------SLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL--DE 147 V I M L YLH I HRD+KP N L ++ Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 148 NGVLKLADFGLAKSFGSPNR----AYTHQVVTRWYRAPELLFGA-RMYGVGVDMWAVGCI 202 + +KL DFGL+K F N T + T ++ APE+L YG D W+ G + Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 203 LAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS 262 L LL+ PG +D D ++++ P+Y Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLNK---------KLCFENPNYNVL------------- 303 Query: 263 AAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 DL+ L N R A +AL+ + S Sbjct: 304 --SPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSD 339 >2OZA-A nrPDB Length = 356 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 81/338 (23%), Positives = 131/338 (38%), Gaps = 50/338 (14%) Query: 10 KRYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL-Q 67 Y+ LG G V + +K T + A+K ++ + A RE++L + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----------ARREVELHWR 66 Query: 68 ELSHPNIIGLLDAFGH----KSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 P+I+ ++D + + + + +V + ++ I T M Sbjct: 67 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + ++YLH I HRD+KP NLL N +LKL DFG AK S N + T T +Y Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYY 185 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE+L G Y DMW++G I+ LL P + L + + E Sbjct: 186 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE--- 241 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP S +++ LI+ L P R+T T+ + + Sbjct: 242 -------------FPNPEW----SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ- 283 Query: 299 PGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 ++P+ P LKE +K + T AL Sbjct: 284 -----STKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 316 >3ORZ-A nrPDB Length = 316 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 120/311 (38%), Gaps = 39/311 (12%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + ++ LGEG F+TV AR+ T++ AIK ++ H K+ RE ++ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHI--IKENKVPYVTRERDVMSRL 94 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HP + L F + + + + + + Y + LEYLH Sbjct: 95 DHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLH 154 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT--HQVVTRWYRAPELLFGA 187 I+HRDLKP N+LL+E+ +++ DFG AK ++ V T Y +PELL Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-E 213 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 + D+WA+GCI+ +L+ +P ++ +I + E+ +P Sbjct: 214 KSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK-------- 265 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ------ALKMKYFSNRPGP 301 DL++ L + + R+ + +F + Sbjct: 266 --------------------ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 305 Query: 302 TPGCQLPRPNC 312 Q P Sbjct: 306 NLHQQTPPKLT 316 >4D2V-A nrPDB Length = 356 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 113/333 (33%), Gaps = 36/333 (10%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D K YE + +G G FA V A T ++VAIK + E Sbjct: 22 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG----SDLPRIKTE 77 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 I+ L+ L H +I L + I +V ++ + L+ + + Sbjct: 78 IEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIV 137 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGL-AKSFGSPNRAYTHQVVTRWYRAP 181 + Y+H HRDLKP NLL DE LKL DFGL AK G+ + Y AP Sbjct: 138 SAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 EL+ G G D+W++G +L L+ D+ + +I Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGK------------ 245 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 + + + L+Q + +P RI+ L + Sbjct: 246 ----------------YDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY 289 Query: 302 TPGCQLPRPNCPVETLKEQSNPALAIKRKRTEA 334 Q P L + L++ + Sbjct: 290 PVEWQS---KNPFIHLDDDCVTELSVHHRNNRQ 319 >5X3F-B nrPDB Length = 393 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 121/313 (38%), Gaps = 40/313 (12%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 ++ +++++ LG G F V + K + A+K + + K L E ++L Sbjct: 81 AQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQI--EHTLNEKRIL 138 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Q ++ P ++ L +F SN+ +V +++ + H + Y + E Sbjct: 139 QAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 198 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 YLH +++RDLKP NLL+D+ G +++ DFG AK R +T T Y APE++ Sbjct: 199 YLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWT-LCGTPEYLAPEIIL- 254 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 ++ Y VD WA+G ++ E+ P D + +I Sbjct: 255 SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP------------- 301 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGP 301 S DL DL++ L + R K+F+ Sbjct: 302 ---------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 346 Query: 302 TP-GCQLPRPNCP 313 ++ P P Sbjct: 347 AIYQRKVEAPFIP 359 >4YNZ-A nrPDB Length = 342 Score = 234 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 120/304 (39%), Gaps = 38/304 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y LG+GQ V T Q VAIK + R + + + REI +L+ + H Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVN---REKLSESVLMKVEREIAILKLIEH 68 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P+++ L D + +K + LV + + LTP + + + L++ H H Sbjct: 69 PHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 128 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 I HRDLKP NLLLDE +++ADFG+A S + + Y PE++ G + G Sbjct: 129 SICHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDG 187 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D+W+ G IL LL+ D+ L ++ + Sbjct: 188 RKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVF--------------------- 226 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPN 311 H+ D L++G+ + R+T K ++ G P P Sbjct: 227 -------HMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY------IGGKNEPEPE 273 Query: 312 CPVE 315 P+ Sbjct: 274 QPIP 277 >4WB7-A nrPDB Length = 405 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 119/310 (38%), Gaps = 40/310 (12%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++E++ LG G F V + K T A+K + + K L E ++LQ + Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI--EHTLNEKRILQAV 153 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + P ++ L +F SN+ +V +++ + H + Y + EYLH Sbjct: 154 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 213 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 +++RDLKP NLL+D+ G +++ DFG AK R +T T Y APE++ ++ Sbjct: 214 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWT-LCGTPEYLAPEIIL-SKG 269 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y VD WA+G ++ E+ P D + +I Sbjct: 270 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP---------------- 313 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGPTP- 303 S DL DL++ L + R K+F+ Sbjct: 314 ------------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIY 361 Query: 304 GCQLPRPNCP 313 ++ P P Sbjct: 362 QRKVEAPFIP 371 >4B8L-A nrPDB Length = 286 Score = 234 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 69/291 (23%), Positives = 112/291 (38%), Gaps = 33/291 (11%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 K ++ LG+G+F VY AR+K I+A+K + K+G+ REI++ Sbjct: 11 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVL--FKSQLEKEGVEHQLRREIEI 68 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L HPNI+ + + F + I L+ +F +M L Sbjct: 69 QSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADAL 128 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 Y H+ ++HRD+KP NLL+ G LK+ADFG + +P+ T Y PE++ Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEMIE 186 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 G + + VD+W G + E L+ +P S + RI Sbjct: 187 G-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV----------------- 228 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 D DLI L ++P R+ ++ + Sbjct: 229 -----------DLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4RA4-A nrPDB Length = 355 Score = 234 bits (596), Expect = 7e-62, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 115/315 (36%), Gaps = 38/315 (12%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + + L LG+G F V A K T ++ AIK +K +D + E ++ Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVV--IQDDDVECTMVEKRV 73 Query: 66 LQELSHP-NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L L P + L F + V +++ + Y G Sbjct: 74 LALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIG 133 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 L +LH+ I++RDLK +N++LD G +K+ADFG+ K T Y APE++ Sbjct: 134 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII 193 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + YG VD WA G +L E+L P G+ + + I E S P Sbjct: 194 -AYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME-----------HNVSYP 241 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA-----TQALKMKYFSNRP 299 + + + + +GL +P R+ + +F Sbjct: 242 KSL-----------------SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRID 284 Query: 300 GPT-PGCQLPRPNCP 313 ++ P P Sbjct: 285 WEKLENREIQPPFKP 299 >4AW2-A nrPDB Length = 437 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 68/317 (21%), Positives = 122/317 (38%), Gaps = 36/317 (11%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 ++ + +E L +G G F V + KN +++ A+K + + + E Sbjct: 67 KQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETAC--FREE 124 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVLTPSHIKAYMLMT 121 +L I L AF +N+ LV D+ + DL ++ L + Y+ Sbjct: 125 RDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEM 184 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH-QVVTRWYRA 180 + ++ +HQ +HRD+KP+N+L+D NG ++LADFG + V T Y + Sbjct: 185 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 244 Query: 181 PELLF----GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 PE+L G YG D W++G + E+L +S ++ +I Sbjct: 245 PEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN--------- 295 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALKMK 293 + FP + ++ DLI+ + + R+ K Sbjct: 296 ---------HKERFQFPTQ-----VTDVSENAKDLIRR-LICSREHRLGQNGIEDFKKHP 340 Query: 294 YFSNRPGPT-PGCQLPR 309 +FS C+ P Sbjct: 341 FFSGIDWDNIRNCEAPY 357 >2HW6-A nrPDB Length = 307 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 110/303 (36%), Gaps = 43/303 (14%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNI 74 + LGEG +A V A + A+K I + RE++ L + + NI Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKII-----EKQAGHSRSRVFREVETLYQCQGNKNI 73 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + L++ F + LVF+ ++ + + L++LH I Sbjct: 74 LELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIA 133 Query: 135 HRDLKPNNLLLDEN---GVLKLADFGLAKSFGSPNR-------AYTHQVVTRWYRAPELL 184 HRDLKP N+L + +K+ DF L N T + Y APE++ Sbjct: 134 HRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVV 193 Query: 185 F----GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 A Y D+W++G +L +L P G G ++ Sbjct: 194 EVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH------------CGADCGWDRGEV 241 Query: 241 CSLPDYVTFKS-------FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 C + F+S FP HI + DLI L + + R++A Q L+ Sbjct: 242 CRVCQNKLFESIQEGKYEFPDKDWAHI----SSEAKDLISKLLVRDAKQRLSAAQVLQHP 297 Query: 294 YFS 296 + Sbjct: 298 WVQ 300 >3TKU-A nrPDB Length = 433 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 124/311 (39%), Gaps = 35/311 (11%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 + +++ + +E + +G G F V + KNT +I A+K + + + Sbjct: 81 LVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC--FR 138 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVLTPSHIKAYML 119 E +L I L AF ++++ LV D+ + DL ++ L + Y+ Sbjct: 139 EERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIG 198 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH-QVVTRWY 178 + ++ +HQ +HRD+KP+N+LLD NG ++LADFG + V T Y Sbjct: 199 EMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDY 258 Query: 179 RAPELLF----GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 +PE+L G YG D W++G + E+L +S ++ +I E Sbjct: 259 ISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN-----HE 313 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALK 291 E++ FP + ++ DLIQ + + R+ K Sbjct: 314 ERF-------------QFPSH-----VTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKK 354 Query: 292 MKYFSNRPGPT 302 +F Sbjct: 355 HAFFEGLNWEN 365 >1U5R-A nrPDB Length = 348 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 129/317 (40%), Gaps = 35/317 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + L +G G F VY ARD +++VAIKK+ + + + + ++E++ LQ+L H Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS--YSGKQSNEKWQDIIKEVRFLQKLRH 113 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 PN I + + LV ++ +++ + L I A LQGL YLH H Sbjct: 114 PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL--FGARM 189 ++HRD+K N+LL E G++KL DFG A N V T ++ APE++ Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN----SFVGTPYWMAPEVILAMDEGQ 229 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y VD+W++G EL R P L + + L I + + P + S Sbjct: 230 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI-------AQNESPALQSGH----- 277 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL-P 308 + + + P R T+ LK ++ PT L Sbjct: 278 --------------WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQ 323 Query: 309 RPNCPVETLKEQSNPAL 325 R V L + Sbjct: 324 RTKDAVRELDNLQYRKM 340 >5LOH-A nrPDB Length = 341 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 69/321 (21%), Positives = 116/321 (36%), Gaps = 40/321 (12%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 +A+ + + + + G F VY + ++ A+K +K + Sbjct: 27 IAVPKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINK--NMTHQVQ 82 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 E L P I+ L + +N+ LV +++ + Y+ Sbjct: 83 AERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISE 142 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN------RAYTHQVV 174 L+YLH+H I+HRDLKP+N+L+ G +KL DFGL+K + + Sbjct: 143 VALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCG 202 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 T Y APELL G R +G VD WA+G L E L +P ++ I + Sbjct: 203 TPDYLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKR------ 255 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 IP D+ ++ L + R + + Sbjct: 256 -------------------DIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPL 296 Query: 295 FSNRPGPTPGCQ----LPRPN 311 FS+ Q +P+P+ Sbjct: 297 FSDVDWENLQHQTMPFIPQPD 317 >2GCD-A nrPDB Length = 309 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 81/317 (25%), Positives = 129/317 (40%), Gaps = 35/317 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + L +G G F VY ARD +++VAIKK+ + + + + ++E++ LQ+L H Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS--YSGKQSNEKWQDIIKEVRFLQKLRH 74 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 PN I + + LV ++ +++ + L I A LQGL YLH H Sbjct: 75 PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL--FGARM 189 ++HRD+K N+LL E G++KL DFG A N V T ++ APE++ Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN----SFVGTPYWMAPEVILAMDEGQ 190 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y VD+W++G EL R P L + + L I + + P + S Sbjct: 191 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI-------AQNESPALQSGH----- 238 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL-P 308 + + + P R T+ LK ++ PT L Sbjct: 239 --------------WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQ 284 Query: 309 RPNCPVETLKEQSNPAL 325 R V L + Sbjct: 285 RTKDAVRELDNLQYRKM 301 >4U41-A nrPDB Length = 332 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 116/314 (36%), Gaps = 45/314 (14%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 ++ A +E ++ +G G + VYK R T Q+ AIK + + E + + E Sbjct: 17 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL------E 70 Query: 63 IKLLQELSHP-NIIGLLDAF------GHKSNISLVFDFMETDL--EVIIKDNSLVLTPSH 113 I +L++ SH NI AF GH + LV +F +++ L Sbjct: 71 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 130 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV 173 I L+GL +LH H ++HRD+K N+LL EN +KL DFG++ + Sbjct: 131 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 190 Query: 174 VTRWYRAPELLFGARM----YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 T ++ APE++ Y D+W+ G E+ P L + L I Sbjct: 191 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR-- 248 Query: 230 GTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 P I+G + N R + Q Sbjct: 249 ------------------------NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQL 284 Query: 290 LKMKYFSNRPGPTP 303 LK + ++P Sbjct: 285 LKHPFIRDQPNERQ 298 >4C0T-A nrPDB Length = 974 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 124/310 (40%), Gaps = 44/310 (14%) Query: 1 MALDVKSRAK---RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR 57 M ++K+ + ++ LGEG ++TV A DK T + A+K + H + K Sbjct: 254 MDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYV 313 Query: 58 TALREIKLLQELSHP-NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKA 116 E L LS+ +I L F K ++ V D+ + + L + Sbjct: 314 NI--EKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRH 371 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY------- 169 + L ++Y+H + ++HRDLKP N+LLD+ +++ DFG A+ N Sbjct: 372 FGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDV 431 Query: 170 --THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 V T Y +PELL + G D+WA GCI+ +++ P ++ +I + Sbjct: 432 RAKSFVGTAEYVSPELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITK 490 Query: 228 TLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT 287 + FP I + DLI+ + + P R T Sbjct: 491 L----------------QFAFSAGFPTI------------IRDLIKKILVLQPSRRATIP 522 Query: 288 QALKMKYFSN 297 + K +F + Sbjct: 523 EIQKHYFFQS 532 >4AF3-A nrPDB Length = 292 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 78/287 (27%), Positives = 115/287 (40%), Gaps = 33/287 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +E LG+G+F VY AR+K ++ IVA+K + K+G+ REI++ L Sbjct: 23 DDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVL--FKSQIEKEGVEHQLRREIEIQAHL 80 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 HPNI+ L + F + I L+ ++ S M L Y H Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCH 140 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 ++HRD+KP NLLL G LK+ADFG + +P+ T Y PE++ G RM Sbjct: 141 GKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEMIEG-RM 197 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 + VD+W +G + ELL+ P S + RI + Sbjct: 198 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV--------------------D 237 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 FP + DLI L NP R+ Q + Sbjct: 238 LKFPA--------SVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVR 276 >6CKI-A nrPDB Length = 316 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 81/329 (24%), Positives = 122/329 (37%), Gaps = 43/329 (13%) Query: 5 VKSRAKRYEKL-----DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA 59 S + R+E + D LGEG A V + T+Q A+K I + I Sbjct: 3 TDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKII-----EKQPGHIRSRV 57 Query: 60 LREIKLLQELS-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYM 118 RE+++L + H N++ L++ F + LVF+ M + + Sbjct: 58 FREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVV 117 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV---LKLADFGLAKSFGSPNR-------A 168 L++LH I HRDLKP N+L + +K+ DFGL Sbjct: 118 QDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPE 177 Query: 169 YTHQVVTRWYRAPELL----FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTR 224 + Y APE++ A +Y D+W++G IL LL P G D Sbjct: 178 LLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSD---- 233 Query: 225 IFETLGTPTEEQWPDMCSLPDYVTFK---SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 G E P ++ + FP HI A DLI L + + Sbjct: 234 ----CGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCA----AKDLISKLLVRDAK 285 Query: 282 ARITATQALKMKYFSNRPGPTPGCQLPRP 310 R++A Q L+ + G P LP P Sbjct: 286 QRLSAAQVLQHPWVQ---GCAPENTLPTP 311 >5XVU-A nrPDB Length = 332 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 89/310 (28%), Positives = 154/310 (49%), Gaps = 26/310 (8%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 ++ RYE + +G G+++ V+ D N+ A K + REIK+L Sbjct: 28 NKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA--------IKVLKPVKKKKIKREIKIL 79 Query: 67 QELSH-PNIIGLLDAFGHK--SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 Q L+ PNII LLD SL+F+++ + T I+ Y+ L+ Sbjct: 80 QNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTL---YPKFTDKDIRYYIYQILK 136 Query: 124 GLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 L+Y H I+HRD+KP+N+++D EN ++L +GLA F P + Y +V +R+Y+ PE Sbjct: 137 ALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGPE 195 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 LL ++Y +D+W++GC+LA ++ + PF G + DQL +I + LGT + Sbjct: 196 LLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKY 255 Query: 242 SL---PDYVTF-KSFPGIPLHHIFSA-----AGDDLLDLIQGLFLFNPCARITATQALKM 292 ++ P Y+ + P H + A D+++DLI + +++ RI +A++ Sbjct: 256 NIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 Query: 293 KYFSNRPGPT 302 YF + Sbjct: 316 PYFREVREES 325 >2PVN-A nrPDB Length = 352 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 80/306 (26%), Positives = 138/306 (45%), Gaps = 24/306 (7%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 YE + +G G+++ V++ + N N+ K + + L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE-------KCIIKILKPVKKKKIKREIKILQNLC 104 Query: 70 SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 PNI+ LLD H SL+F+++ ++ LT I+ Y+ L+ L+Y Sbjct: 105 GGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL---YPTLTDYDIRYYIYELLKALDY 161 Query: 128 LHQHWILHRDLKPNNLLLDENGV-LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I+HRD+KP+N+++D L+L D+GLA F P + Y +V +R+++ PELL Sbjct: 162 CHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVD 220 Query: 187 ARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTP---------TEEQ 236 + Y +DMW++GC+ A ++ R PF G + DQL +I + LGT E Sbjct: 221 LQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIEL 280 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 P + +L + K + + +D + L ++ R+TA +A+ YF Sbjct: 281 DPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQ 340 Query: 297 NRPGPT 302 Sbjct: 341 QVRAAE 346 >2WTK-C nrPDB Length = 305 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 129/317 (40%), Gaps = 38/317 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 +Y D LGEG + V + D T A+ KI + +EI+LL+ L Sbjct: 5 GKYLMGDLLGEGSYGKVKEVLDSETLCRRAV-KILKKKKLRRIPNGEANVKKEIQLLRRL 63 Query: 70 SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKD-NSLVLTPSHIKAYMLMTLQGLE 126 H N+I L+D K + +V ++ ++ ++ Y + GLE Sbjct: 64 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLE 123 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG--SPNRAYTHQVVTRWYRAPELL 184 YLH I+H+D+KP NLLL G LK++ G+A++ + + + ++ PE+ Sbjct: 124 YLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIA 183 Query: 185 FGARMY-GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 G + G VD+W+ G L + + GD+ + ++FE +G + Sbjct: 184 NGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGSY--------- 230 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 I G L DL++G+ + P R + Q + +F + P Sbjct: 231 ---------------AIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKH---P 272 Query: 304 GCQLPRPNCPVETLKEQ 320 + P P P K++ Sbjct: 273 PAEAPVPIPPSPDTKDR 289 >6CQF-A nrPDB Length = 297 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 116/289 (40%), Gaps = 30/289 (10%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + Y+ L LG G + V+KARDK + +VA+K +K+ D T +EI + Sbjct: 12 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM-----EPDDDVSTLQKEILI 66 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L+ H NI+ ++ + + +F I + L+ I LQGL Sbjct: 67 LKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGL 126 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL-- 183 YLH +HRD+K N+L+++ G ++LADFG++ G+ + T ++ APE+ Sbjct: 127 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAA 186 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + Y D+W++G EL P L L L Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVL--------------------- 225 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 ++ KS P + I+ +P R +AT+ L Sbjct: 226 --FLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >6BDL-A nrPDB Length = 347 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 117/315 (37%), Gaps = 39/315 (12%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + + +D LG G F V + K ++ A+K +K H + + E +++ Sbjct: 32 KLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQ--QEHIRSEKQIM 89 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 Q I+ L F + ++ + I + S + Y ++ Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 149 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 YLH I++RDLKP NL+LD G KL DFG AK G + +T T Y APE++ Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT-FCGTPEYVAPEIILN 208 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 + + + D W++G ++ ELL P G + I + DM P Sbjct: 209 -KGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI---------DMIEFPK- 257 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFS--NRP 299 + +LI+ L NP R+ K K+F N Sbjct: 258 ----------------KIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 301 Query: 300 GPTPGCQLPRPNCPV 314 G G P P P Sbjct: 302 GLRKGTLTP-PIIPS 315 >4WNO-A nrPDB Length = 287 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 116/300 (38%), Gaps = 41/300 (13%) Query: 11 RYEKLDFLGEGQFATVYKARDKNT-NQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + + D +G G FA V+K R + + VA+K I + ++++ + + EIK+L+EL Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGK----EIKILKEL 74 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 H NI+ L D +++ LV ++ L+ I+ ++ + LH Sbjct: 75 KHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLH 134 Query: 130 QHWILHRDLKPNNLLLDENG---------VLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 I+HRDLKP N+LL +K+ADFG A+ S A T + Y A Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMA 193 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ ++ Y D+W++G I+ + L S D L +E T P Sbjct: 194 PEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD-LRLFYEKNKTLVP-TIPRE 250 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 S P + N R+ + + P Sbjct: 251 TSAPLRQLLLALLQR-----------------------NHKDRMDFDEFFHHPFLDASPS 287 >2WQN-A nrPDB Length = 310 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 68/278 (24%), Positives = 120/278 (43%), Gaps = 31/278 (11%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 + +G GQF+ VY+A VA+KK+++ +AK ++EI LL++L+ Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAK--ARADCIKEIDLLKQLN 90 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLE----VIIKDNSLVLTPSHIKAYMLMTLQGLE 126 HPN+I +F + +++V + + K ++ + Y + LE Sbjct: 91 HPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALE 150 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 ++H ++HRD+KP N+ + GV+KL D GL + F S A V T +Y +PE + Sbjct: 151 HMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIH- 209 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 Y D+W++GC+L E+ GD ++ SL Sbjct: 210 ENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM--------------------NLYSLCKK 249 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + +P +P H ++L L+ +P R Sbjct: 250 IEQCDYPPLPSDHY----SEELRQLVNMCINPDPEKRP 283 >5UNP-A nrPDB Length = 369 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 73/338 (21%), Positives = 133/338 (39%), Gaps = 53/338 (15%) Query: 10 KRYEKLDFLGEGQFATVYKAR-DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +RYE + LGEG F V + + VA+K IK + A EI +L++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK------NVEKYKEAARLEINVLEK 87 Query: 69 LS-----HPNI-IGLLDAFGHKSNISLVFDFMETDLEVIIKDN-SLVLTPSHIKAYMLMT 121 ++ + N+ + + D F + ++ + F+ + +KDN L ++ Sbjct: 88 INEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 122 LQGLEYLHQHWILHRDLKPNNLL-LDENGV------------------LKLADFGLAKSF 162 Q +++LH + + H DLKP N+L ++ + +++ DFG A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF- 206 Query: 163 GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL 222 + ++ V TR YRAPE++ + D+W++GCI+ E + + + L Sbjct: 207 --DHEHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHL 263 Query: 223 TRIFETLGTPT----------------EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGD 266 + LG W + S YV P + Sbjct: 264 AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHH 323 Query: 267 DLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304 L DLI+ + + P R+T +AL+ +F+ P Sbjct: 324 QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 361 >3A8W-A nrPDB Length = 345 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 123/312 (39%), Gaps = 30/312 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + ++ L +G G +A V R K T++I A+K +K ++ +D E + ++ Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDID--WVQTEKHVFEQA 66 Query: 70 -SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 +HP ++GL F +S + V +++ + L H + Y L YL Sbjct: 67 SNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYL 126 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H+ I++RDLK +N+LLD G +KL D+G+ K P + T Y APE+L G Sbjct: 127 HERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGED 186 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 YG VD WA+G ++ E++ + +G+ + DY+ Sbjct: 187 -YGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPD----QNTEDYLF 228 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA------TQALKMKYFSNRPGP- 301 I + +++ +P R+ +F N Sbjct: 229 QVILEKQ--IRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDM 286 Query: 302 TPGCQLPRPNCP 313 Q+ P P Sbjct: 287 MEQKQVVPPFKP 298 >2BRG-A nrPDB Length = 297 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 120/290 (41%), Gaps = 31/290 (10%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + ++ + LGEG + V A ++ T + VA+K + + + + I + EI + + L Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKK----EICINKML 62 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 +H N++ + L ++ + + + + + + G+ YLH Sbjct: 63 NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--THQVVTRWYRAPELLFGA 187 I HRD+KP NLLLDE LK++DFGLA F NR T Y APELL Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 + VD+W+ G +L +L LP D D W + + + Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGE--LPWDQPSDSCQE---------YSDWKEKKTYLN-- 229 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 P I SA L+ + + NP ARIT K ++++ Sbjct: 230 --------PWKKIDSAPLA----LLHKILVENPSARITIPDIKKDRWYNK 267 >3KN6-A nrPDB Length = 325 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 110/286 (38%), Gaps = 30/286 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-SHPNI 74 LGEG F+ K K +NQ A+K I + +EI L+ HPNI Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKR--------MEANTQKEITALKLCEGHPNI 68 Query: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + L + F + + LV + + + + M + + ++H ++ Sbjct: 69 VKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVV 128 Query: 135 HRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 HRDLKP NLL ++N +K+ DFG A+ N+ T Y APELL Y Sbjct: 129 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYD 187 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D+W++G IL +L T E + + + S Sbjct: 188 ESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF-------------S 234 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 F G ++ + DLIQGL +P R+ + ++ + Sbjct: 235 FEGEAWKNV----SQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >6QAU-A nrPDB Length = 280 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 65/227 (28%), Positives = 108/227 (47%), Gaps = 17/227 (7%) Query: 11 RYEKLDFLGEGQFATVYKARDKN-TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Y K D +G G FA V++ R + T+ VAIK I + S+++ + + EIK+L+EL Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK----EIKILKEL 67 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 H NI+ L D +++ LV ++ L+ I+ ++ + LH Sbjct: 68 QHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILH 127 Query: 130 QHWILHRDLKPNNLLLD---------ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 I+HRDLKP N+LL +K+ADFG A+ S N + Y A Sbjct: 128 SKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHS-NMMAADLCGSPMYMA 186 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 PE++ ++ Y D+W++G ++ + L+ P +S D L +E Sbjct: 187 PEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD-LRMFYE 231 >4MD7-E nrPDB Length = 391 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 144/299 (48%), Gaps = 24/299 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Y+ + LG G+++ V++A + N+ + + K + ++ ++ L+ Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLR-- 89 Query: 70 SHPNIIGLLDAFGHK--SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 PNII L D +LVF+ + K LT I+ YM L+ L+Y Sbjct: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDY 146 Query: 128 LHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I+HRD+KP+N+++D E+ L+L D+GLA F P + Y +V +R+++ PELL Sbjct: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 Query: 187 ARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT + D ++ Sbjct: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Query: 246 YVTFKS----FPGIPLHHIFSA-----AGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 F + + LD + L ++ +R+TA +A++ YF Sbjct: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >3LM0-A nrPDB Length = 327 Score = 223 bits (569), Expect = 9e-59, Method: Composition-based stats. Identities = 76/324 (23%), Positives = 126/324 (38%), Gaps = 37/324 (11%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH-PNI 74 LG G+FA V + K+T Q A K +K R + L EI +L+ P + Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQ---DCRAEILHEIAVLELAKSCPRV 91 Query: 75 IGLLDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 I L + + + S I L+ ++ + + + + +++ + + + L+G+ YLHQ+ Sbjct: 92 INLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNN 151 Query: 133 ILHRDLKPNNLLLDEN---GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 I+H DLKP N+LL G +K+ DFG+++ G + T Y APE+L Sbjct: 152 IVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHA-CELREIMGTPEYLAPEIL-NYDP 209 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 DMW +G I LL G+ + + I + +EE Sbjct: 210 ITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEE-------------- 255 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPR 309 FS+ D IQ L + NP R TA L + P Sbjct: 256 ----------TFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQ--WDFENLFHPE 303 Query: 310 PNCPVETLKEQSNPALAIKRKRTE 333 ++ S + K ++ Sbjct: 304 ETSSSSQTQDHSVRSSEDKTSKSS 327 >4XEY-B nrPDB Length = 408 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 121/293 (41%), Gaps = 44/293 (15%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LG GQ+ VY+ K + VA+K +K L+E +++E+ Sbjct: 126 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME------VEEFLKEAAVMKEIK 179 Query: 71 HPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML-MTLQGLEYL 128 HPN++ LL + ++ +FM +L +++ + + + YM +EYL Sbjct: 180 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 239 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLF 185 + +HRDL N L+ EN ++K+ADFGL++ YT ++ + APE L Sbjct: 240 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL- 296 Query: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + + D+WA G +L E+ + PG L++++E L + P+ C Sbjct: 297 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID----LSQVYELLEKDYRMERPEGCPEK 352 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Y +L++ + +NP R + + + F Sbjct: 353 VY-----------------------ELMRACWQWNPSDRPSFAEI--HQAFET 380 >2FO0-A nrPDB Length = 495 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 121/293 (41%), Gaps = 44/293 (15%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LG GQ+ VY+ K + VA+K +K L+E +++E+ Sbjct: 218 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME------VEEFLKEAAVMKEIK 271 Query: 71 HPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML-MTLQGLEYL 128 HPN++ LL + ++ +FM +L +++ + + + YM +EYL Sbjct: 272 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 331 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLF 185 + +HR+L N L+ EN ++K+ADFGL++ YT ++ + APE L Sbjct: 332 EKKNFIHRNLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL- 388 Query: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + + D+WA G +L E+ + PG L++++E L + P+ C Sbjct: 389 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID----LSQVYELLEKDYRMERPEGCPEK 444 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Y +L++ + +NP R + + + F Sbjct: 445 VY-----------------------ELMRACWQWNPSDRPSFAEI--HQAFET 472 >6E2O-A nrPDB Length = 295 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 118/285 (41%), Gaps = 35/285 (12%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 LG+G + VY RD + +AIK+I E ++ EI L + L H NI+ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIP-----ERDSRYSQPLHEEIALHKHLKHKNIVQ 83 Query: 77 LLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLT--PSHIKAYMLMTLQGLEYLHQHWI 133 L +F I + + + L +++ L I Y L+GL+YLH + I Sbjct: 84 YLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 143 Query: 134 LHRDLKPNNLLLDE-NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL-FGARMYG 191 +HRD+K +N+L++ +GVLK++DFG +K N T Y APE++ G R YG Sbjct: 144 VHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYG 203 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D+W++GC + E+ P E ++ FK Sbjct: 204 KAADIWSLGCTIIEMATGKPPF--------------------YELGEPQAAMFKVGMFKV 243 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 P IP + + I F +P R A L ++ Sbjct: 244 HPEIP-----ESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >5MJB-A nrPDB Length = 305 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 61/247 (24%), Positives = 109/247 (44%), Gaps = 17/247 (6%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQ---IVAIKKIKLGHRSEAKDGINRT 58 A ++ + E + +G G+F VYK R K + VAIK +K G+ + + R Sbjct: 20 AKEIDVSFVKIE--EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQR----RD 73 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAY 117 L E ++ + H NII L + ++ +FME L+ ++ N T + Sbjct: 74 FLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGM 133 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP--NRAYTHQVVT 175 + G++YL + +HRDL N+L++ N V K++DFGL++ + YT + Sbjct: 134 LRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGG 193 Query: 176 R---WYRAPELLFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGT 231 + + APE + R + D+W+ G ++ E + S+ D + I + Sbjct: 194 KIPVRWTAPEAI-AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRL 252 Query: 232 PTEEQWP 238 P P Sbjct: 253 PPPMDCP 259 >3NYO-A nrPDB Length = 576 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 113/313 (36%), Gaps = 36/313 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + + LG+G F V + + T ++ A KL + K AL E ++L++++ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYA--CKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVII--KDNSLVLTPSHIKAYMLMTLQGLEYLH 129 ++ L A+ K + LV M + Y GLE LH Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 + I++RDLKP N+LLD++G ++++D GLA + +V T Y APE++ R Sbjct: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPEVVKNER- 361 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y D WA+GC+L E++ + + + EE Sbjct: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF--------- 412 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGPTPG 304 L L +P R+ +A + + F G Sbjct: 413 ---------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLG 457 Query: 305 C-QLPRPNCPVET 316 L P P Sbjct: 458 AGMLEPPFKPDPQ 470 >3RAW-A nrPDB Length = 381 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 129/330 (39%), Gaps = 53/330 (16%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQ-IVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 +RYE + LGEG F V + D + VA+K I+ + A EI +L++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGK------YREAARLEINVLKK 104 Query: 69 L---SHPN---IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMT 121 + N + + D F ++ + F+ + + +K+N+ H++ Sbjct: 105 IKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQL 164 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD-------------------ENGVLKLADFGLAKSF 162 L +LH++ + H DLKP N+L +N +++ADFG A Sbjct: 165 CHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF- 223 Query: 163 GSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL 222 + +T V TR YR PE++ + D+W++GCIL E + + L Sbjct: 224 --DHEHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL 280 Query: 223 TRIFETLGTPTEE----------------QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGD 266 + + LG W + S YV P S Sbjct: 281 VMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV 340 Query: 267 DLLDLIQGLFLFNPCARITATQALKMKYFS 296 L DL++ + F+P RIT +AL +F+ Sbjct: 341 QLFDLMRRMLEFDPAQRITLAEALLHPFFA 370 >6HMD-A nrPDB Length = 365 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 84/302 (27%), Positives = 150/302 (49%), Gaps = 30/302 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Y+ + LG G+++ V++A + N+ ++ + K + ++ ++ L+ Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 107 Query: 70 SHPNIIGLLDAFGHK--SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 + NII L+D +LVF+++ K +LT I+ YM L+ L+Y Sbjct: 108 T--NIIKLIDTVKDPVSKTPALVFEYINNTD---FKQLYQILTDFDIRFYMYELLKALDY 162 Query: 128 LHQHWILHRDLKPNNLLLDE-NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I+HRD+KP+N+++D L+L D+GLA F P + Y +V +R+++ PELL Sbjct: 163 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 221 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGT------------PT 233 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT Sbjct: 222 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 281 Query: 234 EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 + + D+ +++F H+ + LDL+ L ++ R+TA +A++ Sbjct: 282 DPHFNDILGQHSRKRWENFIHSENRHL---VSPEALDLLDKLLRYDHQQRLTAKEAMEHP 338 Query: 294 YF 295 YF Sbjct: 339 YF 340 >3PFQ-A nrPDB Length = 674 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 116/324 (35%), Gaps = 38/324 (11%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + + L LG+G F V + K T+++ A+K +K +D + E ++ Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVI--QDDDVECTMVEKRV 394 Query: 66 LQELSHP-NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L P + L F + V +++ + H Y G Sbjct: 395 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 454 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 L +L I++RDLK +N++LD G +K+ADFG+ K T Y APE++ Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + YG VD WA G +L E+L G+ + + I E +P Sbjct: 515 -AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-----HNVAYPK----- 563 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA-----TQALKMKYFSNRP 299 + + + + +GL +P R+ + +F Sbjct: 564 ------------------SMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 605 Query: 300 GPT-PGCQLPRPNCPVETLKEQSN 322 ++ P P + + N Sbjct: 606 WEKLERKEIQPPYKPKASGRNAEN 629 >2WO6-A nrPDB Length = 382 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 82/342 (23%), Positives = 141/342 (41%), Gaps = 61/342 (17%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 RYE +G+G F V KA D+ + VAIK IK + I E++LL+ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI------EVRLLEL 106 Query: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKD-NSLVLTPSHIKAYMLMT 121 ++ I+ L F ++++ LVF+ + +L ++++ N ++ + + + Sbjct: 107 MNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQM 166 Query: 122 LQGLEYLH--QHWILHRDLKPNNLLL--DENGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 L +L + I+H DLKP N+LL + +K+ DFG + G Y + +R+ Sbjct: 167 CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRF 223 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 YR+PE+L G Y + +DMW++GCIL E+ P G +++DQ+ +I E LG P Sbjct: 224 YRSPEVLLGM-PYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 282 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGD------------------------------- 266 + F+ P + + G Sbjct: 283 DQAPKARKF--FEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESG 340 Query: 267 -------DLLDLIQGLFLFNPCARITATQALKMKYFSNRPGP 301 DLI + ++P RI AL+ +F Sbjct: 341 HTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >6NPU-A nrPDB Length = 298 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 66/293 (22%), Positives = 121/293 (41%), Gaps = 44/293 (15%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LG GQ+ VY+ K + VA+K +K L+E +++E+ Sbjct: 27 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME------VEEFLKEAAVMKEIK 80 Query: 71 HPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML-MTLQGLEYL 128 HPN++ LL + ++ +FM +L +++ + + + YM +EYL Sbjct: 81 HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 140 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLF 185 + +HRDL N L+ EN ++K+ADFGL++ YT ++ + APE L Sbjct: 141 EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL- 197 Query: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + + D+WA G +L E+ + PG L++++E L + P+ C Sbjct: 198 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGID----LSQVYELLEKDYRMERPEGCPEK 253 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Y +L++ + +NP R + + + F Sbjct: 254 VY-----------------------ELMRACWQWNPSDRPSFAEI--HQAFET 281 >4EBW-A nrPDB Length = 304 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 110/288 (38%), Gaps = 41/288 (14%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTAL 60 D + + +R E +GEGQF V++ N VAIK K + D + L Sbjct: 32 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK----NCTSDSVREKFL 87 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML 119 +E +++ HP+I+ L+ + + ++ + +L ++ L + + Y Sbjct: 88 QEALTMRQFDHPHIVKLIGVITE-NPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAY 146 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVTRW 177 L YL +HRD+ N+L+ N +KL DFGL++ +A ++ +W Sbjct: 147 QLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKW 206 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 APE + R + D+W G + E+L+ V G + D + RI P Sbjct: 207 -MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPN 264 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 P L L+ + ++P R Sbjct: 265 CP---------------------------PTLYSLMTKCWAYDPSRRP 285 >3VN9-A nrPDB Length = 340 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 129/300 (43%), Gaps = 40/300 (13%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + +A E + LG G + V K R + QI+A+K+I+ S+ + + L ++ + Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLDI 102 Query: 66 -LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLMT 121 ++ + P + A + ++ + + M+T L+ K D + + + Sbjct: 103 SMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSI 162 Query: 122 LQGLEYLHQH-WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 ++ LE+LH ++HRD+KP+N+L++ G +K+ DFG++ + A T + Y A Sbjct: 163 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DSVAKTIDAGCKPYMA 221 Query: 181 PELL---FGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 PE + + Y V D+W++G + EL +LR P+ + QL ++ E Sbjct: 222 PERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE--------- 272 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + P +P + +D N R T + ++ +F+ Sbjct: 273 -------------EPSPQLPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >6BXI-A nrPDB Length = 333 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 122/337 (36%), Gaps = 68/337 (20%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + +E L +G G F V + K+T + A+K ++ E + + A R Sbjct: 1 TRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAER--D 58 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +L E ++ + +F K N+ L+ +F+ + + LT + Y+ T+ Sbjct: 59 ILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLA 118 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA---------------- 168 ++ +HQ +HRD+KP+NLLLD G +KL+DFGL +R Sbjct: 119 IDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTF 178 Query: 169 -------------------YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR 209 V T Y APE+ Y D W++G I+ E+L+ Sbjct: 179 QNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQT-GYNKLCDWWSLGVIMYEMLIG 237 Query: 210 VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLL 269 P ++ + ++ W + + P P +P + Sbjct: 238 YPPFCSETPQETYKKVMN---------WKETLTFP--------PEVP-------ISEKAK 273 Query: 270 DLIQG-LFLFNPCARITA---TQALKMKYFSNRPGPT 302 DLI + RI A + +F Sbjct: 274 DLILRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWEH 308 >6DBN-A nrPDB Length = 316 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 74/294 (25%), Positives = 124/294 (42%), Gaps = 28/294 (9%) Query: 3 LDVKSRAKRY-EKLDFLGEGQFATVYKARDK----NTNQIVAIKKIKLGHRSEAKDGINR 57 +D KR+ +++ LGEG F V R NT + VA+K +K E+ Sbjct: 27 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK----PESGGNHIA 82 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKSN--ISLVFDFME-TDLEVIIKDNSLVLTPSHI 114 +EI++L+ L H NI+ I L+ +F+ L+ + N + Sbjct: 83 DLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQ 142 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---H 171 Y + +G++YL +HRDL N+L++ +K+ DFGL K+ + YT Sbjct: 143 LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD 202 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 + ++ APE L ++ Y + D+W+ G L ELL DSD + + +G Sbjct: 203 RDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIG- 255 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 PT Q + K P P D++ L++ + F P R + Sbjct: 256 PTHGQMTVTRLVNTLKEGKRLPCPP------NCPDEVYQLMRKCWEFQPSNRTS 303 >2H8H-A nrPDB Length = 535 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 118/298 (39%), Gaps = 46/298 (15%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 LG+G F V+ T + VAIK +K G S L+E +++++L H ++ Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKLRHEKLVQ 326 Query: 77 LLDAFGHKSNISLVFDFME-TDLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + I +V ++M L +K + L + G+ Y+ + + Sbjct: 327 LYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 385 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYG 191 HRDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE R + Sbjct: 386 HRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FT 442 Query: 192 VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 + D+W+ G +L EL PG + + L ++ P + P Sbjct: 443 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------ 490 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 + L DL+ + P R T + L+ + + T P Sbjct: 491 ---------------ESLHDLMCQCWRKEPEERPT-FEYLQ-AFLEDYFTSTEPQYQP 531 >6EII-A nrPDB Length = 352 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 144/299 (48%), Gaps = 24/299 (8%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Y+ + LG G+++ V++A + N+ + + K + ++ ++ L+ Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLR-- 112 Query: 70 SHPNIIGLLDAFGHK--SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 PNII L D +LVF+ + K LT I+ YM L+ L+Y Sbjct: 113 GGPNIITLADIVKDPVSRTPALVFEHVNNTD---FKQLYQTLTDYDIRFYMYEILKALDY 169 Query: 128 LHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 H I+HRD+KP+N+++D E+ L+L D+GLA F P + Y +V +R+++ PELL Sbjct: 170 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 228 Query: 187 ARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 +MY +DMW++GC+LA ++ R PF G + DQL RI + LGT + D ++ Sbjct: 229 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 288 Query: 246 YVTFKS----FPGIPLHHIFSA-----AGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 F + + LD + L ++ +R+TA +A++ YF Sbjct: 289 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >5L6P-A nrPDB Length = 298 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 116/272 (42%), Gaps = 17/272 (6%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + + +G G+F V + R K + VAIK +K+G+ + R L E ++ + Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQR----RDFLSEASIMGQF 77 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HPNII L + ++ +FME L+ ++ N T + + G++YL Sbjct: 78 DHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL 137 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP--NRAYTHQVVTR---WYRAPEL 183 + +HRDL N+L++ N V K++DFGL++ + YT + + + APE Sbjct: 138 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEA 197 Query: 184 LFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 + R + D+W+ G ++ E + S+ D + + + P P + Sbjct: 198 I-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCP--TA 254 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQG 274 L + L FS + L LI+ Sbjct: 255 LHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRN 286 >2R2P-A nrPDB Length = 295 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 117/284 (41%), Gaps = 20/284 (7%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALRE 62 + A +G G+F V R K + VAIK +K+G+ + + R L E Sbjct: 18 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQR----RDFLGE 73 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + HPNII L + +V ++ME L+ +K N T + + Sbjct: 74 ASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 133 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV--TRWY 178 G++YL +HRDL N+L++ N V K++DFGL++ P AYT + + Sbjct: 134 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 193 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE + R + D+W+ G ++ E++ ++ D + + E P+ Sbjct: 194 TAPEAI-AFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDC 252 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 P + D++++++ + NP Sbjct: 253 PAA------LYQLMLDCWQKERNSRPKFDEIVNMLDK-LIRNPA 289 >6F3F-A nrPDB Length = 455 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 118/298 (39%), Gaps = 46/298 (15%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 LG+G F V+ T + VAIK +K G S L+E +++++L H ++ Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKLRHEKLVQ 246 Query: 77 LLDAFGHKSNISLVFDFME-TDLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + I +V ++M L +K + L + G+ Y+ + + Sbjct: 247 LYAVVSEE-PIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYV 305 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYG 191 HRDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE R + Sbjct: 306 HRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FT 362 Query: 192 VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 + D+W+ G +L EL PG + + L ++ P + P Sbjct: 363 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------ 410 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 + L DL+ + P R T + L+ + + T P Sbjct: 411 ---------------ESLHDLMCQCWRKEPEERPT-FEYLQ-AFLEDYFTSTEPQYQP 451 >2I0E-A nrPDB Length = 353 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 111/315 (35%), Gaps = 38/315 (12%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + + L LG+G F V + K T+++ A+K +K +D + E ++ Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVI--QDDDVECTMVEKRV 73 Query: 66 LQELSHP-NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L P + L F + V +++ + H Y G Sbjct: 74 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 133 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 L +L I++RDLK +N++LD G +K+ADFG+ K T Y APE++ Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + YG VD WA G +L E+L G+ + + I E Sbjct: 194 -AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH---------------- 236 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA-----TQALKMKYFSNRP 299 + + + + +GL +P R+ + +F Sbjct: 237 ------------NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 284 Query: 300 GPT-PGCQLPRPNCP 313 ++ P P Sbjct: 285 WEKLERKEIQPPYKP 299 >4FR4-A nrPDB Length = 384 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 63/306 (20%), Positives = 120/306 (39%), Gaps = 35/306 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 + +E L +G+G F V + +T ++ A+K + E + R + Sbjct: 7 DENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEV--RNVFK 64 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E++++Q L HP ++ L +F + ++ +V D + ++ +K ++ Sbjct: 65 ELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICEL 124 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 + L+YL I+HRD+KP+N+LLDE+G + + DF +A + T T+ Y AP Sbjct: 125 VMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQI-TTMAGTKPYMAP 183 Query: 182 ELLFGAR--MYGVGVDMWAVGCILAELLLRVPFLP--GDSDLDQLTRIFETLGTPTEEQW 237 E+ + Y VD W++G ELL + ++ FET W Sbjct: 184 EMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAW 243 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT-ATQALKMKYFS 296 +++ L++ L NP R + + Y + Sbjct: 244 ---------------------------SQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMN 276 Query: 297 NRPGPT 302 + Sbjct: 277 DINWDA 282 >3PPZ-A nrPDB Length = 309 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 114/303 (37%), Gaps = 43/303 (14%) Query: 14 KLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 + +G G F TV++A ++ VA+K + + LRE+ +++ L HPN Sbjct: 41 IKEKIGAGSFGTVHRAEWHGSD--VAVKIL---MEQDFHAERVNEFLREVAIMKRLRHPN 95 Query: 74 IIGLLDAFGHKSNISLVFDFME-TDLEVIIKDN--SLVLTPSHIKAYMLMTLQGLEYLHQ 130 I+ + A N+S+V +++ L ++ + L + +G+ YLH Sbjct: 96 IVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHN 155 Query: 131 HW--ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 I+HRDLK NLL+D+ +K+ DFGL++ S + T + APE+L Sbjct: 156 RNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEP 215 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 D+++ G IL EL Q P P V Sbjct: 216 S-NEKSDVYSFGVILWELAT--------------------------LQQPWGNLNPAQVV 248 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 I + +I+G + P R + + + P +P Sbjct: 249 AAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIM------DLLRPLIKSAVP 302 Query: 309 RPN 311 PN Sbjct: 303 PPN 305 >4E93-A nrPDB Length = 377 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 110/286 (38%), Gaps = 41/286 (14%) Query: 14 KLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 + +G G F V+ R + N +VA+K R + L+E ++L++ SHPN Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVK----SCRETLPPDLKAKFLQEARILKQYSHPN 173 Query: 74 IIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 I+ L+ K I +V + + D ++ L + + G+EYL Sbjct: 174 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKC 233 Query: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH---QVVTRWYRAPELLFGARM 189 +HRDL N L+ E VLK++DFG+++ A + QV +W APE L Sbjct: 234 CIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW-TAPEAL-NYGR 291 Query: 190 YGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 Y D+W+ G +L E P S+ + + P E PD Sbjct: 292 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDA-------- 343 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALK 291 + L++ + + P R T Q L+ Sbjct: 344 -------------------VFRLMEQCWAYEPGQRPSFSTIYQELQ 370 >2VD5-A nrPDB Length = 412 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 120/323 (37%), Gaps = 38/323 (11%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 +V+ + +E L +G G F+ V + K T Q+ A+K + K G E Sbjct: 54 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDM--LKRGEVSCFREE 111 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVLTPSHIKAYMLMT 121 +L I L AF ++ + LV ++ + DL ++ + + Y+ Sbjct: 112 RDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEI 171 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT-HQVVTRWYRA 180 + ++ +H+ +HRD+KP+N+LLD G ++LADFG + + V T Y + Sbjct: 172 VMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLS 231 Query: 181 PELLFG------ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 PE+L YG D WA+G E+ DS + +I Sbjct: 232 PEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV-------- 283 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALK 291 + + SLP + ++ D IQ L P R+ A Sbjct: 284 -HYKEHLSLP--------------LVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRT 327 Query: 292 MKYFSNRPGPTPGCQLPRPNCPV 314 +F +P P P Sbjct: 328 HPFFFGLDWDGLRDSVP-PFTPD 349 >4P5Q-A nrPDB Length = 361 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 112/292 (38%), Gaps = 40/292 (13%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALRE 62 + A +G G+F V R K ++ VAIK +K+G+ + + R L E Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQR----RDFLGE 84 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + HPNII L + +V ++ME L+ ++ + T + + Sbjct: 85 ASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGI 144 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV--TRWY 178 G++YL +HRDL N+L++ N V K++DFGL++ P AYT + + Sbjct: 145 ASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 204 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 +PE + R + D+W+ G +L E + S+ D + + E P Sbjct: 205 TSPEAI-AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDC 263 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 P L L+ + + R Q Sbjct: 264 PAA---------------------------LYQLMLDCWQKDRNNRPKFEQI 288 >2Y6O-A nrPDB Length = 291 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 60/241 (24%), Positives = 104/241 (43%), Gaps = 13/241 (5%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALRE 62 + A + +G G+F V R K + VAIK +K G+ + + R L E Sbjct: 10 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQR----RDFLSE 65 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + HPNII L + ++ ++ME L+ ++ N T + + Sbjct: 66 ASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGI 125 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV--TRWY 178 G++YL +HRDL N+L++ N V K++DFG+++ P AYT + + Sbjct: 126 GSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW 185 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE + R + D+W+ G ++ E + S+ D + I E P Sbjct: 186 TAPEAI-AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDC 244 Query: 238 P 238 P Sbjct: 245 P 245 >1JPA-A nrPDB Length = 312 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 102/237 (43%), Gaps = 15/237 (6%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + +G G+F V K + VAIK +K G+ + + R L E ++ + Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQR----RDFLSEASIMGQF 91 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HPN+I L + + ++ +FME L+ ++ N T + + G++YL Sbjct: 92 DHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYL 151 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP--NRAYTHQVVTR---WYRAPEL 183 +HRDL N+L++ N V K++DFGL++ + YT + + + APE Sbjct: 152 ADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEA 211 Query: 184 LFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 + R + D+W+ G ++ E + ++ D + I + P P Sbjct: 212 IQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPS 267 >5KKR-C nrPDB Length = 395 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 130/318 (40%), Gaps = 32/318 (10%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + +EK+ LG G V+K K + ++A K I L E K I +RE+++ Sbjct: 64 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQV 119 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L E + P I+G AF IS+ + M+ + + + + + ++GL Sbjct: 120 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 179 Query: 126 EYL-HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 YL +H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L Sbjct: 180 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERL 237 Query: 185 FGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWP----- 238 G Y V D+W++G L E+ + P P D+ +L + G E Sbjct: 238 QGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 296 Query: 239 --------------DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + L DY+ + P +P + D + + NP R Sbjct: 297 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVF----SLEFQDFVNKCLIKNPAERA 352 Query: 285 TATQALKMKYFSNRPGPT 302 Q + + Sbjct: 353 DLKQLMVHAFIKRSDAEE 370 >4OLI-A nrPDB Length = 645 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 123/297 (41%), Gaps = 34/297 (11%) Query: 2 ALDVKSRAKRY-EKLDFLGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGIN 56 A D KRY +K+ LGEG F V Y + T ++VA+K +K + + G Sbjct: 344 ASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWK 403 Query: 57 RTALREIKLLQELSHPNIIGLLDAFGHKSN--ISLVFDFME-TDLEVIIKDNSLVLTPSH 113 + EI +L+ L H +II + + LV +++ L + +S+ L + Sbjct: 404 Q----EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGL--AQ 457 Query: 114 IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ- 172 + + +G+ YLH +HR+L N+LLD + ++K+ DFGLAK+ + Y + Sbjct: 458 LLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRE 517 Query: 173 ---VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 WY APE L + Y D+W+ G L ELL DS T+ E + Sbjct: 518 DGDSPVFWY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELI 570 Query: 230 G-TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 G + + L + P ++ L++ + R T Sbjct: 571 GIAQGQMTVLRLTELLERGERLPRP--------DKCPCEVYHLMKNCWETEASFRPT 619 Score = 114 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 55/319 (17%), Positives = 101/319 (31%), Gaps = 70/319 (21%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKAR------------------------DKNTNQIVAIK 41 + K +L LG+G VY+ R D+ V +K Sbjct: 41 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 100 Query: 42 KIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEV 100 + H I L+ ++SH ++ + +V +++E L+V Sbjct: 101 VLDPSHH-----DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 155 Query: 101 IIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV-------LKL 153 ++ + + L YL ++H ++ N+LL G+ +KL Sbjct: 156 WLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL 215 Query: 154 ADFGLAKSFGSPNRAYTHQVVTRWYRAPELL-FGARMYGVGVDMWAVGCILAELLLRVPF 212 +D G G + +V + APE L GA +D W G L E+ Sbjct: 216 SDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC----- 266 Query: 213 LPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLI 272 G++ L +P+E++ H + + L L Sbjct: 267 FDGEAPLQ--------SRSPSEKE---------------HFYQRQHRLPEPSCPQLATLT 303 Query: 273 QGLFLFNPCARITATQALK 291 + P R + L+ Sbjct: 304 SQCLTYEPTQRPSFRTILR 322 >3DKO-A nrPDB Length = 318 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 102/241 (42%), Gaps = 13/241 (5%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALRE 62 + A + +G G+F V R K + VAIK +K+G+ + + R L E Sbjct: 39 ELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQR----RDFLCE 94 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + HPN++ L + +V +FME L+ ++ + T + + Sbjct: 95 ASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGI 154 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV--TRWY 178 G+ YL +HRDL N+L++ N V K++DFGL++ P YT + Sbjct: 155 AAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRW 214 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE + R + D+W+ G ++ E + S+ D + I E P Sbjct: 215 TAPEAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDC 273 Query: 238 P 238 P Sbjct: 274 P 274 >2J0K-A nrPDB Length = 656 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 109/288 (37%), Gaps = 41/288 (14%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTAL 60 D + + +R E +GEGQF V++ N VAIK K + D + L Sbjct: 384 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK----NCTSDSVREKFL 439 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML 119 +E +++ HP+I+ L+ + + ++ + +L ++ L + + Y Sbjct: 440 QEALTMRQFDHPHIVKLIGVITE-NPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAY 498 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVTRW 177 L YL +HRD+ N+L+ +KL DFGL++ +A ++ +W Sbjct: 499 QLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKW 558 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 APE + R + D+W G + E+L+ V G + D + RI P Sbjct: 559 -MAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPN 616 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 P L L+ + ++P R Sbjct: 617 CP---------------------------PTLYSLMTKCWAYDPSRRP 637 >2XYN-A nrPDB Length = 292 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 120/293 (40%), Gaps = 44/293 (15%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LG GQ+ VY K + VA+K +K L+E +++E+ Sbjct: 33 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME------VEEFLKEAAVMKEIK 86 Query: 71 HPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML-MTLQGLEYL 128 HPN++ LL + +V ++M +L +++ + + + YM +EYL Sbjct: 87 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 146 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLF 185 + +HRDL N L+ EN V+K+ADFGL++ YT ++ + APE L Sbjct: 147 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESL- 203 Query: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + + D+WA G +L E+ + PG L+++++ L + P+ C Sbjct: 204 AYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID----LSQVYDLLEKGYRMEQPEGCPPK 259 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 Y +L++ + ++P R + + + F Sbjct: 260 VY-----------------------ELMRACWKWSPADRPSFAE--THQAFET 287 >6CCF-A nrPDB Length = 290 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 67/316 (21%), Positives = 121/316 (38%), Gaps = 52/316 (16%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSE---------------- 50 + +Y+ +G+G + V A +++ ++ A+K + + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 51 -----AKDGINRTALREIKLLQELSHPNIIGLLDAFGH--KSNISLVFDFMETDLEVIIK 103 + +EI +L++L H N++ L++ + N+ LVFD + + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVP 121 Query: 104 DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG 163 + + Y+ + GLEYLH I+HRD+KP+NLLL ++G +K+ADFG++ F Sbjct: 122 -CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 164 SPNRAYTHQVVTRWYRAPELL--FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 + + T + APE + G G +D+WA G L + D L Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILAL 240 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 +I EE ++L DLI + NP Sbjct: 241 HRKIKNEPVVFPEE--------------------------PEISEELKDLILKMLDKNPE 274 Query: 282 ARITATQALKMKYFSN 297 RI + + Sbjct: 275 TRIGVPDIKLHPWVTK 290 >3FME-A nrPDB Length = 290 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 129/301 (42%), Gaps = 40/301 (13%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ +A E + LG G + V K R + QI+A+K+I+ S+ + + L ++ Sbjct: 2 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ----KRLLMDLD 57 Query: 65 L-LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIK---DNSLVLTPSHIKAYMLM 120 + ++ + P + A + ++ + + M+T L+ K D + + + Sbjct: 58 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVS 117 Query: 121 TLQGLEYLHQH-WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 ++ LE+LH ++HRD+KP+N+L++ G +K+ DFG++ + A + Y Sbjct: 118 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV-DDVAKDIDAGCKPYM 176 Query: 180 APELL---FGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFETLGTPTEE 235 APE + + Y V D+W++G + EL +LR P+ + QL ++ E Sbjct: 177 APERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE-------- 228 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + P +P + +D N R T + ++ +F Sbjct: 229 --------------EPSPQLPADKF----SAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 Query: 296 S 296 + Sbjct: 271 T 271 >4AN9-A nrPDB Length = 301 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 127/303 (41%), Gaps = 35/303 (11%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 MAL + + +EK+ LG G V+K K + ++A K I L E K I + Sbjct: 1 MAL-GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQII 55 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 RE+++L E + P I+G AF IS+ + M+ + + + + + Sbjct: 56 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIA 115 Query: 121 TLQGLEYL-HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 ++GL YL +H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y Sbjct: 116 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDEMANEFVGTRSYM 173 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 +PE L G Y V D+W++G L E+ + P + IFE L E P Sbjct: 174 SPERLQGT-HYSVQSDIWSMGLSLVEMAVGRYPRPPMA-------IFELLDYIVNEPPPK 225 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 + S + F+ D + + NP R Q + + Sbjct: 226 LPSAVFSLEFQ-------------------DFVNKCLIKNPAERADLKQLMVHAFIKRSD 266 Query: 300 GPT 302 Sbjct: 267 AEE 269 >2XNP-A nrPDB Length = 279 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 77/298 (25%), Positives = 123/298 (41%), Gaps = 42/298 (14%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 SRA+ YE L +G G + K R K+ +I+ K++ G +EA+ + + E+ LL Sbjct: 3 SRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAE---KQMLVSEVNLL 59 Query: 67 QELSHPNIIGLLDAFGHKSN--ISLVFDFMET-DLEVIIKD---NSLVLTPSHIKAYMLM 120 +EL HPNI+ D ++N + +V ++ E DL +I L + M Sbjct: 60 RELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQ 119 Query: 121 TLQGLEYLHQ-----HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVT 175 L+ H+ H +LHRDLKP N+ LD +KL DFGLA+ V T Sbjct: 120 LTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGT 179 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 235 +Y +PE + Y D+W++GC+L EL +P S + +I E Sbjct: 180 PYYMSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG------- 231 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 I D+L ++I + R + + L+ Sbjct: 232 --------------------KFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENP 269 >3ALO-A nrPDB Length = 327 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 121/297 (40%), Gaps = 36/297 (12%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 A+ + L +G G + +V K K + QI+A+K+I+ + + + +++ Sbjct: 20 TAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD---VVMR 76 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLT----PSHIKAYMLMTLQ 123 P I+ A + + + + M T + K VL + L T++ Sbjct: 77 SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK 136 Query: 124 GLEYLHQH-WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 L +L ++ I+HRD+KP+N+LLD +G +KL DFG++ + A T R Y APE Sbjct: 137 ALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLV-DSIAKTRDAGCRPYMAPE 195 Query: 183 LLF---GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 + + Y V D+W++G L EL P+ +S DQLT++ + P Sbjct: 196 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG-------DPP 248 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295 + + + ++ + + R + LK + Sbjct: 249 QLSNSEE----------------REFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >3EQC-A nrPDB Length = 360 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 130/318 (40%), Gaps = 32/318 (10%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + +EK+ LG G V+K K + ++A K I L E K I +RE+++ Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL----EIKPAIRNQIIRELQV 84 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L E + P I+G AF IS+ + M+ + + + + + ++GL Sbjct: 85 LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGL 144 Query: 126 EYL-HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 YL +H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y +PE L Sbjct: 145 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERL 202 Query: 185 FGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWP----- 238 G Y V D+W++G L E+ + P P D+ +L + G E Sbjct: 203 QGT-HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 261 Query: 239 --------------DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + L DY+ + P +P + D + + NP R Sbjct: 262 RPLNKFGMDSRPPMAIFELLDYIVNEPPPKLP----SGVFSLEFQDFVNKCLIKNPAERA 317 Query: 285 TATQALKMKYFSNRPGPT 302 Q + + Sbjct: 318 DLKQLMVHAFIKRSDAEE 335 >3C51-A nrPDB Length = 543 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 113/308 (36%), Gaps = 36/308 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + LG G F V+ + K T ++ A KL + K + A+ E K+L ++ Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYA--CKKLNKKRLKKRKGYQGAMVEKKILAKVHS 244 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVII----KDNSLVLTPSHIKAYMLMTLQGLEY 127 I+ L AF K+++ LV M +++ Y + GLE+ Sbjct: 245 RFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEH 304 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 LHQ I++RDLKP N+LLD++G ++++D GLA + T + APELL G Sbjct: 305 LHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGE 364 Query: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 Y VD +A+G L E++ G E + L V Sbjct: 365 E-YDFSVDYFALGVTLYEMIAARGPF-------------RARGEKVENKELKQRVLEQAV 410 Query: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGPT 302 T+ D + L +P R+ + F + Sbjct: 411 TYPDKF-----------SPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQ 459 Query: 303 PGCQLPRP 310 + P Sbjct: 460 LEAGMLTP 467 >6DBM-A nrPDB Length = 318 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 122/296 (41%), Gaps = 34/296 (11%) Query: 3 LDVKSRAKRY-EKLDFLGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINR 57 D KRY +K+ LGEG F V Y + T ++VA+K +K + + G + Sbjct: 23 GDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQ 82 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKS--NISLVFDFME-TDLEVIIKDNSLVLTPSHI 114 EI +L+ L H +II ++ LV +++ L + +S+ L + + Sbjct: 83 ----EIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGL--AQL 136 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ-- 172 + +G+ YLH +HRDL N+LLD + ++K+ DFGLAK+ + Y + Sbjct: 137 LLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 196 Query: 173 --VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 WY APE L + Y D+W+ G L ELL DS T+ E +G Sbjct: 197 GDSPVFWY-APECLKEYKFY-YASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIG 249 Query: 231 -TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 + + L + P ++ L++ + R T Sbjct: 250 IAQGQMTVLRLTELLERGERLPRP--------DKCPAEVYHLMKNCWETEASFRPT 297 >5SYS-A nrPDB Length = 286 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 118/298 (39%), Gaps = 46/298 (15%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 LG+G F + T + VAIK +K G S L+E +++++L H ++ Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKLRHEKLVQ 77 Query: 77 LLDAFGHKSNISLVFDFME-TDLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 L + I +V ++M L +K + L + G+ Y+ + + Sbjct: 78 LYAVVSEE-PIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYV 136 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYG 191 HRDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE R + Sbjct: 137 HRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FT 193 Query: 192 VGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 + D+W+ G +L EL PG + + L ++ P + P Sbjct: 194 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------ 241 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLP 308 + L DL+ + +P R T + L+ + + T P Sbjct: 242 ---------------ESLHDLMCQCWRKDPEERPT-FEYLQ-AFLEDYFTSTEPQYQP 282 >1TKI-A nrPDB Length = 321 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 125/293 (42%), Gaps = 37/293 (12%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y + LG G+F V++ + ++ + K +K+ + +EI +L Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQV------LVKKEISILNIA 58 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNS--LVLTPSHIKAYMLMTLQGLEY 127 H NI+ L ++F + ++F+F+ L++ + N+ L I +Y+ + L++ Sbjct: 59 RHRNILHLHESFESMEELVMIFEFISG-LDIFERINTSAFELNEREIVSYVHQVCEALQF 117 Query: 128 LHQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 LH H I H D++P N++ + +K+ +FG A+ P + Y APE+ Sbjct: 118 LHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQL-KPGDNFRLLFTAPEYYAPEV-H 175 Query: 186 GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + DMW++G ++ LL + +++ + I T EE + ++ Sbjct: 176 QHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEI----- 230 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + +D + L + +R+TA++AL+ + + Sbjct: 231 -------------------SIEAMDFVDRLLVKERKSRMTASEALQHPWLKQK 264 >4E20-A nrPDB Length = 290 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 124/295 (42%), Gaps = 34/295 (11%) Query: 4 DVKSRAKRY-EKLDFLGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRT 58 D KRY +K+ LGEG F V Y + T ++VA+K +K G + + G Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSG---- 56 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSN--ISLVFDFME-TDLEVIIKDNSLVLTPSHIK 115 REI++L+ L H +I+ + + LV +++ L + + + L + + Sbjct: 57 WQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGL--AQLL 114 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ--- 172 + +G+ YLH +HR L N+LLD + ++K+ DFGLAK+ + Y + Sbjct: 115 LFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 174 Query: 173 -VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG- 230 WY APE L + Y D+W+ G L ELL DS+ T+ E +G Sbjct: 175 DSPVFWY-APECLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIGH 227 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 T + + L + P ++ L++ + R T Sbjct: 228 TQGQMTVLRLTELLERGERLPRP--------DRCPCEIYHLMKNCWETEASFRPT 274 >5H2U-A nrPDB Length = 267 Score = 213 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 108/284 (38%), Gaps = 37/284 (13%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ + + LG G F V++ K+ Q VAIK I + + EI+ Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNL-----LHQQMLQSEIQ 54 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNS-LVLTPSHIKAYMLMTL 122 +++L H +I+ L + ++ + M + L +++D+ VL S + Sbjct: 55 AMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVA 114 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 +G+ YL +HRDL N+L+ EN + K+ DFGLA+ + + APE Sbjct: 115 EGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPE 174 Query: 183 LLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 L Y D+W+ G +L E+ PG S+ + R+ P + P Sbjct: 175 AL-SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP--- 230 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 + L+ + +P R T Sbjct: 231 ------------------------PSVHKLMLTCWCRDPEQRPT 250 >4GS6-A nrPDB Length = 315 Score = 213 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 76/332 (22%), Positives = 130/332 (39%), Gaps = 55/332 (16%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K E + +G G F V KA+ + + VAIK+I + + + E++ L + Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI-------ESESERKAFIVELRQLSRV 59 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVL---TPSHIKAYMLMTLQGLE 126 +HPNI+ L A + + LV ++ E + + L T +H ++ L QG+ Sbjct: 60 NHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 117 Query: 127 YLHQHW---ILHRDLKPNNLLLDENGVL-KLADFGLAKSFGSPNRAYTHQVVTRWYRAPE 182 YLH ++HRDLKP NLLL G + K+ DFG A T+ + + APE Sbjct: 118 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ---THMTNNKGSAAWMAPE 174 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 + G+ Y D+++ G IL E++ R + F+ +G P + + Sbjct: 175 VFEGSN-YSEKCDVFSWGIILWEVITR-------------RKPFDEIGGPAFRIMWAVHN 220 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ---ALKM--KYFSN 297 K+ P L+ + +P R + + + +YF Sbjct: 221 GTRPPLIKNLPKPIES------------LMTRCWSKDPSQRPSMEEIVKIMTHLMRYF-- 266 Query: 298 RPGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 PG Q P + + P + Sbjct: 267 -PGADEPLQYPCQHSLPPGEDGRVEPYVDFAE 297 >3V5Q-A nrPDB Length = 297 Score = 213 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 112/308 (36%), Gaps = 59/308 (19%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKN-----TNQIVAIKKIKLGHRSEAKDGINRTALR 61 + + LGEG F V+ A N +VA+K +K + KD R Sbjct: 12 IKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD-----FQR 66 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSL------------- 107 E +LL L H +I+ G + +VF++M+ DL ++ + Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 108 --VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 L S + G+ YL +HRDL N L+ N ++K+ DFG+++ S Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 166 NRAYT--HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL- 222 + H ++ + PE + R + D+W+ G IL E+ G QL Sbjct: 187 DYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFT-----YGKQPWFQLS 240 Query: 223 -TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 T + E + + P +C Y D++ G + P Sbjct: 241 NTEVIECITQGRVLERPRVCPKEVY-----------------------DVMLGCWQREPQ 277 Query: 282 ARITATQA 289 R+ + Sbjct: 278 QRLNIKEI 285 >4AT3-A nrPDB Length = 299 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 109/292 (37%), Gaps = 56/292 (19%) Query: 14 KLDFLGEGQFATVYKARDKN-----TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 LGEG F V+ A N +VA+K +K +A D + RE +LL Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-----DASDNARKDFHREAELLTN 71 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSL------------VLTPSHIK 115 L H +I+ + +VF++M+ DL ++ + LT S + Sbjct: 72 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT--HQV 173 G+ YL +HRDL N L+ EN ++K+ DFG+++ S + H + Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 191 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL--TRIFETLGT 231 + + PE + R + D+W++G +L E+ G QL + E + Sbjct: 192 LPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFT-----YGKQPWYQLSNNEVIECITQ 245 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCAR 283 Q P C Y +L+ G + P R Sbjct: 246 GRVLQRPRTCPQEVY-----------------------ELMLGCWQREPHMR 274 >4TNB-A nrPDB Length = 590 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 118/312 (37%), Gaps = 36/312 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + + LG+G F V + + T ++ A K+++ K AL E ++L++++ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRI--KKRKGESMALNEKQILEKVNS 243 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDN--SLVLTPSHIKAYMLMTLQGLEYLH 129 ++ L A+ K + LV M N + Y L GLE LH Sbjct: 244 QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 ++RDLKP N+LLD+ G ++++D GLA + +V T Y APE+L R Sbjct: 304 HENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVGTVGYMAPEVLNNQR- 361 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 YG+ D W +GC++ E++ G + E+ + V Sbjct: 362 YGLSPDYWGLGCLIYEMIEGQSPFRGRKEK------------VKREEVDRRVLETEEVYS 409 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSN-RPGPTP 303 F ++ + + L + R+ A + + +F N Sbjct: 410 HKF------------SEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLE 457 Query: 304 GCQLPRPNCPVE 315 L P P Sbjct: 458 AGMLDPPFVPDP 469 >2DQ7-X nrPDB Length = 283 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 120/302 (39%), Gaps = 46/302 (15%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + + LG GQF V+ N VAIK +K G S + L E +++++L H Sbjct: 12 QLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSP------ESFLEEAQIMKKLKHD 64 Query: 73 NIIGLLDAFGHKSNISLVFDFME-TDLEVIIKD-NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 ++ L + I +V ++M L +KD L ++ G+ Y+ + Sbjct: 65 KLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 123 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGA 187 +HRDL+ N+L+ + K+ADFGLA+ + YT + ++ + APE Sbjct: 124 MNYIHRDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYG 181 Query: 188 RMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 R + + D+W+ G +L EL+ PG ++ + L ++ P + P Sbjct: 182 R-FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPI------- 233 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 L +L+ + +P R T + L+ + + T Sbjct: 234 --------------------SLHELMIHCWKKDPEERPT-FEYLQ-SFLEDYFTATEPQY 271 Query: 307 LP 308 P Sbjct: 272 QP 273 >2VWV-A nrPDB Length = 302 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 111/288 (38%), Gaps = 44/288 (15%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + + +G G+F V + R K + VAIK +K G+ + R L E ++ + Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQR----REFLSEASIMGQF 74 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 HPNII L + + ++ +FME L+ ++ N T + + G+ YL Sbjct: 75 EHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYL 134 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT------HQVVTRWYRAPE 182 + +HRDL N+L++ N V K++DFGL++ + T ++ RW APE Sbjct: 135 AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRW-TAPE 193 Query: 183 LLFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 + R + D W+ G ++ E + S+ D + I + P P Sbjct: 194 AI-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCP--- 249 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 L L+ + + AR Q Sbjct: 250 ------------------------TSLHQLMLDCWQKDRNARPRFPQV 273 >5UUU-A nrPDB Length = 547 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 124/320 (38%), Gaps = 38/320 (11%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 L++ + +G G F VY R +T ++ A+K + + AL E Sbjct: 191 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL--ALNE 248 Query: 63 IKLLQEL---SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYML 119 +L + P I+ + AF +S + D M V + + ++ Y Sbjct: 249 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 308 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 + GLE++H ++++RDLKP N+LLDE+G ++++D GLA F + V T Y Sbjct: 309 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYM 366 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L Y D +++GC+L +LL D+ I T E Sbjct: 367 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE---- 421 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKY 294 + + +L L++GL + R+ A + + + Sbjct: 422 --------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 461 Query: 295 FSNRPGPTPGCQ-LPRPNCP 313 F + Q P P P Sbjct: 462 FRSLDWQMVFLQKYPPPLIP 481 >4LFI-A nrPDB Length = 374 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 90/340 (26%), Positives = 159/340 (46%), Gaps = 52/340 (15%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAI---------------------- 40 +D + K YE + +G G+++ V++ ++ + I Sbjct: 33 IDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLS 92 Query: 41 -KKIKLGHRSEAKDGINRTALREIKLLQELS----------HPNIIGLLDAFGHK--SNI 87 +K+ KD T +E +L+ + H NII L D Sbjct: 93 NEKVPPTTLPFQKDQYY-TNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 150 Query: 88 SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD- 146 +LVF++++ I+ LT I+ YM L+ L+Y H I+HRD+KP+N+++D Sbjct: 151 ALVFEYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 207 Query: 147 ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAEL 206 +N L+L D+GLA F N Y +V +R+++ PELL RMY +D+W+ G +LA + Sbjct: 208 KNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 266 Query: 207 LL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWP---DMCSLPDYVTFKSFPGIPLHHIFS 262 + R PF G S+ DQL +I + LGT E++ ++ ++ + P H + Sbjct: 267 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 326 Query: 263 ------AAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + D+++DLI L ++ R+TA +A+ +F+ Sbjct: 327 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >3PVW-A nrPDB Length = 695 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 124/320 (38%), Gaps = 38/320 (11%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 L++ + +G G F VY R +T ++ A+K + + AL E Sbjct: 182 LNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL--ALNE 239 Query: 63 IKLLQEL---SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYML 119 +L + P I+ + AF +S + D M V + + ++ Y Sbjct: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAA 299 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 + GLE++H ++++RDLKP N+LLDE+G ++++D GLA F + V T Y Sbjct: 300 EIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS--VGTHGYM 357 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APE+L Y D +++GC+L +LL D+ I T E Sbjct: 358 APEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTMAVE---- 412 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKY 294 + + +L L++GL + R+ A + + + Sbjct: 413 --------------------LPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPF 452 Query: 295 FSNRPGPTPGCQ-LPRPNCP 313 F + Q P P P Sbjct: 453 FRSLDWQMVFLQKYPPPLIP 472 >4EQM-A nrPDB Length = 294 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 72/276 (26%), Positives = 127/276 (46%), Gaps = 7/276 (2%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 K +RY+ +D LG G +TVY A D N VAIK I + R K+ + RE+ Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPRE--KEETLKRFEREVHN 64 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 +LSH NI+ ++D LV +++E ++ L+ + L G+ Sbjct: 65 SSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGI 124 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV-VTRWYRAPELL 184 ++ H I+HRD+KP N+L+D N LK+ DFG+AK+ + T+ V T Y +PE Sbjct: 125 KHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQA 184 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ-LTRIFETLGTPTEEQWPDMCSL 243 G D++++G +L E+L+ P G++ + + I +++ T + D+ Sbjct: 185 KGEAT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQS 243 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN 279 V ++ + ++ D + + N Sbjct: 244 LSNVILRATEKDKANRY--KTIQEMKDDLSSVLHEN 277 >4OTD-A nrPDB Length = 341 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 133/337 (39%), Gaps = 41/337 (12%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + ++ L LG G F V + + + ++ AIK +K G + + + E ++L + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEV--ESLMCEKRILAAV 69 Query: 70 ---SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 HP ++ L F ++ V ++ ++++ +S V + Y + GL+ Sbjct: 70 TSAGHPFLVNLFGCFQTPEHVCFVMEYSAGG-DLMLHIHSDVFSEPRAIFYSACVVLGLQ 128 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 +LH+H I++RDLK +NLLLD G +K+ADFGL K + T + APE+L Sbjct: 129 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTD 188 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 Y VD W +G +L E+L+ PGD + + I D P + Sbjct: 189 T-SYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN-----------DEVRYPRF 236 Query: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGP 301 + + + +++ L NP R+ A K +F Sbjct: 237 L-----------------SAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 279 Query: 302 TPGC-QLPRPNCPVETLKEQSNPALAIKRKRTEALEQ 337 +LP P P + + + L Sbjct: 280 ALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSP 316 >3KUL-B nrPDB Length = 325 Score = 210 bits (534), Expect = 9e-55, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 108/292 (36%), Gaps = 40/292 (13%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALRE 62 + A R +G G V R + Q VAIK +K G+ + R L E Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQR----RDFLSE 100 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + HPNII L +V ++ME L+ ++ + T + + Sbjct: 101 ASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGV 160 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV--TRWY 178 G+ YL +HRDL N+L+D N V K++DFGL++ P+ AYT + Sbjct: 161 GAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRW 220 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE + R + D+W+ G ++ E L ++ D ++ + E P Sbjct: 221 TAPEAI-AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGC 279 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 P L L+ + + R +Q Sbjct: 280 PHA---------------------------LHQLMLDCWHKDRAQRPRFSQI 304 >5VO2-A nrPDB Length = 300 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 111/288 (38%), Gaps = 44/288 (15%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + L ++G G V+ R + VA+KK++ ++ IK Sbjct: 8 EVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD------------IKH 53 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L++L HPNII ++ +F + +TPS + + + G+ Sbjct: 54 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGM 113 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 YLH H I+HRDLK N+L+ + V+K++DFG +K + T + APE++ Sbjct: 114 NYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIR 172 Query: 186 GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + VD+W+ G +L ELL +P+ DS +L P PD + Sbjct: 173 NEPV-SEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKI- 230 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 L++ + P R + Q L Sbjct: 231 --------------------------LLRQCWNSKPRNRPSFRQILLH 252 >3A4O-X nrPDB Length = 286 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 121/286 (42%), Gaps = 43/286 (15%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + + + + LG GQF V+ N+ + VA+K +K G S + L E L Sbjct: 9 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS------VQAFLEEANL 61 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIK-DNSLVLTPSHIKAYMLMTLQ 123 ++ L H ++ L + I ++ ++M + L +K D + + + + Sbjct: 62 MKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAE 121 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRA 180 G+ Y+ + +HRDL+ N+L+ E+ + K+ADFGLA+ + YT + ++ + A Sbjct: 122 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI--EDNEYTAREGAKFPIKWTA 179 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 PE + + + D+W+ G +L E++ PG ++ D +T + + P E PD Sbjct: 180 PEAI-NFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPD 238 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 +L D+++ + R T Sbjct: 239 ---------------------------ELYDIMKMCWKEKAEERPT 257 >1S9I-A nrPDB Length = 354 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 81/322 (25%), Positives = 129/322 (40%), Gaps = 38/322 (11%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A + + +E++ LG G V K + + + I+A K I L E K I +R Sbjct: 8 AKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL----EIKPAIRNQIIR 63 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 E+++L E + P I+G AF IS+ + M+ + + + + + Sbjct: 64 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAV 123 Query: 122 LQGLEYL-HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L+GL YL +H I+HRD+KP+N+L++ G +KL DFG++ + V TR Y A Sbjct: 124 LRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMA 181 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE L G Y V D+W++G L EL + +P + L IF EE P Sbjct: 182 PERLQGT-HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHS 239 Query: 241 CS-------------------------LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGL 275 S L DY+ + P +P D + + Sbjct: 240 ISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTP----DFQEFVNKC 295 Query: 276 FLFNPCARITATQALKMKYFSN 297 + NP R + Sbjct: 296 LIKNPAERADLKMLTNHTFIKR 317 >4IAN-A nrPDB Length = 358 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 86/331 (25%), Positives = 145/331 (43%), Gaps = 51/331 (15%) Query: 10 KRYEKLDFLGEGQFATVYKARDKN-TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 KRY + G+G F+ V +ARD NQ VA+K I+ + + +T L+E++ L++ Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR------NNELMQKTGLKELEFLKK 83 Query: 69 LS------HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV--LTPSHIKAYMLM 120 L+ + + L F HK ++ LVF+ + +L ++K L +++Y Sbjct: 84 LNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQ 143 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVL-KLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L+ L + ILH D+KP+N+L++E+ + KL DFG A + T +V+R+YR Sbjct: 144 LFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYR 201 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE----- 234 APE++ G + Y G+DMW+VGC L EL PG ++ L + G Sbjct: 202 APEIIIG-KSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRK 260 Query: 235 ----EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGD-----------------------D 267 +Q D Y+ + S Sbjct: 261 GVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQ 320 Query: 268 LLDLIQGLFLFNPCARITATQALKMKYFSNR 298 L DL+ + + +P RI+ QAL+ + + Sbjct: 321 LKDLLDQILMLDPAKRISINQALQHAFIQEK 351 >4PDO-A nrPDB Length = 299 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 56/236 (23%), Positives = 102/236 (43%), Gaps = 14/236 (5%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI----VAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + +G G+F VYK K ++ VAIK +K G+ + + L E ++ + Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQR----VDFLGEAGIMGQ 92 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 SH NII L + ++ ++ME L+ +++ + + + G++Y Sbjct: 93 FSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 152 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVV--TRWYRAPELL 184 L +HRDL N+L++ N V K++DFGL++ P YT + APE + Sbjct: 153 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI 212 Query: 185 FGARMYGVGVDMWAVGCILAE-LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 R + D+W+ G ++ E + S+ + + I + PT P Sbjct: 213 -SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPS 267 >4UYA-A nrPDB Length = 340 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 120/302 (39%), Gaps = 46/302 (15%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 V +R E + +G G F VY+A + Q VA+K + +A + R Sbjct: 18 GSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDA-AAAAESVRR 74 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLM 120 E +L L HPNII L + ++ LV +F L + + P + + + Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL--AGRRIPPHVLVNWAVQ 132 Query: 121 TLQGLEYLHQHW---ILHRDLKPNNLLLDE--------NGVLKLADFGLAKSFGSPNRAY 169 +G+ YLH+ ILHRDLK +N+LL E N LK+ DFGLA+ + + Sbjct: 133 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMA 192 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 T + APE++ + ++ G D+W+ G +L ELL G L Sbjct: 193 T--AGAYAWMAPEVIKSS-LFSKGSDIWSYGVLLWELLTGEVPYRGIDGL---------- 239 Query: 230 GTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 Y + +P I S + L++ + +P R + Sbjct: 240 -------------AVAYGVAVNKLTLP---IPSTCPEPFAKLMKECWQQDPHIRPSFALI 283 Query: 290 LK 291 L+ Sbjct: 284 LE 285 >6GQK-A nrPDB Length = 328 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 115/309 (37%), Gaps = 60/309 (19%) Query: 10 KRYEKLDFLGEGQFATVYKARDK-----NTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 R LG G F V +A + + VA+K +K S ++ + E+K Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREA----LMSELK 96 Query: 65 LLQEL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTP----------- 111 +L L +H NI+ LL A H ++ ++ DL ++ P Sbjct: 97 VLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKD 156 Query: 112 ----SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR 167 H+ ++ +G+ +L +HRDL N+LL + K+ DFGLA+ + + Sbjct: 157 FLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSN 216 Query: 168 AY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDS-DLDQL 222 ++ +W APE +F + +Y D+W+ G L EL PG D Sbjct: 217 YVDKGNARLPVKW-MAPESIFNS-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY 274 Query: 223 TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCA 282 I E + E P ++ D+++ + +P Sbjct: 275 KMIKEGFRMSSPEYAPA---------------------------EMYDIMKTCWDADPDK 307 Query: 283 RITATQALK 291 R T Q ++ Sbjct: 308 RPTFKQIVQ 316 >3M42-A nrPDB Length = 299 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 118/338 (34%), Gaps = 71/338 (21%) Query: 10 KRYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL-Q 67 Y+ LG G V + +K T + A+K ++ + A RE++L + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----------ARREVELHWR 66 Query: 68 ELSHPNIIGLLDAFGH----KSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMT 121 P+I+ ++D + + + + +V + ++ I T M Sbjct: 67 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + ++YLH I HRD+KP NLL N +LKL DFG AK Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--------------- 171 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 Y DMW++G I+ LL P + L + + E Sbjct: 172 --------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE--- 220 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 FP S +++ LI+ L P R+T T+ + + Sbjct: 221 -------------FPNPEW----SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ- 262 Query: 299 PGPTPGCQLPR-PNCPVETLKEQSNPALAIKRKRTEAL 335 ++P+ P LKE +K + T AL Sbjct: 263 -----STKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 295 >3QGY-A nrPDB Length = 286 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 65/274 (23%), Positives = 112/274 (40%), Gaps = 24/274 (8%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + +G GQF V+ N ++ VAIK IK G SE + E +++ Sbjct: 24 IDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSED------DFIEEAEVM 76 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 +LSHP ++ L ++ I LVF+FME L ++ + + L +G+ Sbjct: 77 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 136 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPE 182 YL + ++HRDL N L+ EN V+K++DFG+ + YT T++ + +PE Sbjct: 137 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWASPE 194 Query: 183 LLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 + F Y D+W+ G ++ E+ S+ + + E + T P + Sbjct: 195 V-FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE----VVEDISTGFRLYKPRLA 249 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGL 275 S Y L++ L Sbjct: 250 STHVYQIMNHC-----WKERPEDRPAFSRLLRQL 278 >5KMM-A nrPDB Length = 329 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 64/312 (20%), Positives = 106/312 (33%), Gaps = 62/312 (19%) Query: 17 FLGEGQFATVYKARDKN-----TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 LGEG F V+ A N +VA+K +K EA + + RE +LL L H Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-----EASESARQDFQREAELLTMLQH 96 Query: 72 PNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSL--------------VLTPSHIKA 116 +I+ + +VF++M DL ++ + L + A Sbjct: 97 QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 156 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY---THQV 173 G+ YL +HRDL N L+ + V+K+ DFG+++ S + + Sbjct: 157 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 216 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI--FETLGT 231 RW PE + R + D+W+ G +L E+ G QL+ + + Sbjct: 217 PIRW-MPPESIL-YRKFTTESDVWSFGVVLWEIFT-----YGKQPWYQLSNTEAIDCITQ 269 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 E + P C Y ++G + P R + Sbjct: 270 GRELERPRACPPEVYAI-----------------------MRGCWQREPQQRHSIKDV-- 304 Query: 292 MKYFSNRPGPTP 303 P Sbjct: 305 HARLQALAQAPP 316 >5HI2-A nrPDB Length = 283 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 113/293 (38%), Gaps = 39/293 (13%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + +G G F TVYK + VA+K + + E+ Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQL--------QAFKNEV 62 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTL 122 +L++ H NI+ L + K +++V + E L + + + T Sbjct: 63 GVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTA 121 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTHQVVTRWYRA 180 +G++YLH I+HRDLK NN+ L E+ +K+ DFGLA KS S + + + + A Sbjct: 122 RGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 181 Query: 181 PELL--FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 PE++ + Y D++A G +L EL+ ++ DQ I E +G + Sbjct: 182 PEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVGRGSL---- 234 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 L + S + L+ R + + L Sbjct: 235 ---------------SPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILA 272 >1ZXE-A nrPDB Length = 303 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 124/322 (38%), Gaps = 60/322 (18%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 A +E++ LG+G F V KAR+ ++ AIKKI+ + T L E+ LL Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHT------EEKLSTILSEVMLLAS 58 Query: 69 LSHPNIIGLLDAFGHKSN-------------ISLVFDFMET-DLEVIIKDNSLVLTPSHI 114 L+H ++ A+ + N + + ++ E L +I +L Sbjct: 59 LNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEY 118 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS---------- 164 L+ L Y+H I+HR+LKP N+ +DE+ +K+ DFGLAK+ Sbjct: 119 WRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQ 178 Query: 165 ----PNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLD 220 + T + T Y A E+L G Y +DM+++G I E++ PF G ++ Sbjct: 179 NLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVN 236 Query: 221 QLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNP 280 L ++ PD+ K + I+ L +P Sbjct: 237 ILKKLRSVSIEFP----------PDFDDNKMKVEKKI--------------IRLLIDHDP 272 Query: 281 CARITATQALKMKYFSNRPGPT 302 R A L + + Sbjct: 273 NKRPGARTLLNSGWLPVKHQDE 294 >4CRS-A nrPDB Length = 341 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 78/342 (22%), Positives = 134/342 (39%), Gaps = 37/342 (10%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI-KLLQE 68 + + L G F V A KNTN++ AIK +K G + + + I + + Sbjct: 12 QDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNS 71 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 + HP ++ L F K ++ V ++ ++++ ++ V + Y + GL+YL Sbjct: 72 VRHPFLVNLFACFQTKEHVCFVMEYAAGG-DLMMHIHTDVFSEPRAVFYAACVVLGLQYL 130 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 H+H I++RDLK +NLLLD G +K+ADFGL K + T + APE+L Sbjct: 131 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTET- 189 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 Y VD W +G ++ E+L+ PGD + + I D P ++ Sbjct: 190 SYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN-----------DEVRYPRFL- 237 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSNRPGPT- 302 + + +++ L NP R+ A K +F Sbjct: 238 ----------------STEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSAL 281 Query: 303 PGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKL 344 ++ P P +E + L P+ L Sbjct: 282 MDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRIL 323 >3ORP-A nrPDB Length = 311 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 120/272 (44%), Gaps = 11/272 (4%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + RYE + LG G + V+ ARD ++ VA+K ++ + RE + Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPS--FYLRFRREAQNAAA 68 Query: 69 LSHPNIIGLLDAFGHKSN----ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L+HP I+ + D ++ +V ++++ I +TP + Q Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQA 128 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ---VVTRWYRAP 181 L + HQ+ I+HRD+KP N+++ +K+ DFG+A++ + T + T Y +P Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSP 188 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 E G + D++++GC+L E+L P GDS + + P + + Sbjct: 189 EQARGDSV-DARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLS 247 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQ 273 + D V K+ P + + A + DL++ Sbjct: 248 ADLDAVVLKALAKNP-ENRYQTAAEMRADLVR 278 >3SXS-A nrPDB Length = 268 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 117/292 (40%), Gaps = 44/292 (15%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ + + L LG GQF V + K VA+K IK G SE + +E + Sbjct: 3 MELKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMSEDE------FFQEAQ 55 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQ 123 + +LSHP ++ + I +V +++ L ++ + L PS + + Sbjct: 56 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCE 115 Query: 124 GLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRA 180 G+ +L H +HRDL N L+D + +K++DFG+ + Y V T++ + A Sbjct: 116 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQ--YVSSVGTKFPVKWSA 173 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 PE+ + Y D+WA G ++ E+ ++P+ DL + + + P Sbjct: 174 PEVFHYFK-YSSKSDVWAFGILMWEVFSLGKMPY-----DLYTNSEVVLKVSQGHRLYRP 227 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 + A D + ++ + P R T Q L Sbjct: 228 HL-----------------------ASDTIYQIMYSCWHELPEKRPTFQQLL 256 >4UY9-A nrPDB Length = 323 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 116/298 (38%), Gaps = 46/298 (15%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ + +G G F VY+A VA+K + + I +E K Sbjct: 4 LEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTI-ENVRQEAK 60 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQ 123 L L HPNII L + N+ LV +F L ++ + P + + + + Sbjct: 61 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS--GKRIPPDILVNWAVQIAR 118 Query: 124 GLEYLHQHW---ILHRDLKPNNLLL--------DENGVLKLADFGLAKSFGSPNRAYTHQ 172 G+ YLH I+HRDLK +N+L+ N +LK+ DFGLA+ + + Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SA 176 Query: 173 VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 T + APE++ + M+ G D+W+ G +L ELL G L Sbjct: 177 AGTYAWMAPEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRGIDGL------------- 222 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 Y + +P I S + L++ + +P +R + T L Sbjct: 223 ----------AVAYGVAMNKLALP---IPSTCPEPFAKLMEDCWNPDPHSRPSFTNIL 267 >4YHJ-A nrPDB Length = 584 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 114/312 (36%), Gaps = 36/312 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + LG+G F V + + T ++ A KL + K AL E ++L+++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYA--CKKLQKKRIKKRKGEAMALNEKRILEKVQS 244 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDN--SLVLTPSHIKAYMLMTLQGLEYLH 129 ++ L A+ K + LV M N + Y GLE L Sbjct: 245 RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQ 304 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 + I++RDLKP N+LLD+ G ++++D GLA R +V T Y APE++ + Sbjct: 305 RERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRV-RGRVGTVGYMAPEVVNNEK- 362 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 Y D W +GC++ E++ + + + + + TEE Sbjct: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE-------------- 408 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSN-RPGPTP 303 +D + + L NP R+ A + F + Sbjct: 409 ----------YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLE 458 Query: 304 GCQLPRPNCPVE 315 L P CP Sbjct: 459 ANMLEPPFCPDP 470 >3Q4U-A nrPDB Length = 301 Score = 203 bits (517), Expect = 8e-53, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 50/314 (15%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ A+ L+ +G+G++ V++ + + VA+K ++ RE +L Sbjct: 4 RTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFS--------SRDEKSWFRETEL 53 Query: 66 LQ--ELSHPNIIGLLDAFGHKSN----ISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYM 118 L H NI+G + + + + L+ + E L ++ L + Sbjct: 54 YNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT--TLDTVSCLRIV 111 Query: 119 LMTLQGLEYLH--------QHWILHRDLKPNNLLLDENGVLKLADFGLA----KSFGSPN 166 L GL +LH + I HRDLK N+L+ +NG +AD GLA +S + Sbjct: 112 LSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLD 171 Query: 167 RAYTHQVVTRWYRAPELLFGARMYG-----VGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 +V T+ Y APE+L VD+WA G +L E+ R+ Sbjct: 172 VGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRM----------V 221 Query: 222 LTRIFETLGTPTEEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFL 277 I E P + P+ S D + P IP L L++ + Sbjct: 222 SNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWY 281 Query: 278 FNPCARITATQALK 291 NP AR+TA + K Sbjct: 282 QNPSARLTALRIKK 295 >4XLV-A nrPDB Length = 328 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 110/317 (34%), Gaps = 58/317 (18%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYK--ARDKNTNQ---IVAIKKIKLGHRSEAKDGINRT 58 + + ++ L LG+G F VY+ ARD + VA+K + A Sbjct: 33 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN----ESASLRERIE 88 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKD---------NSLV 108 L E +++ + +++ LL +V + M DL+ ++ Sbjct: 89 FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPP 148 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 T + G+ YL+ +HRDL N ++ + +K+ DFG+ + + Sbjct: 149 PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY 208 Query: 169 YTHQVV--TRWYRAPELLFGARMYGVGVDMWAVGCILAEL--LLRVPFLPGDSDLDQLTR 224 + APE L ++ DMW+ G +L E+ L P+ G S+ L Sbjct: 209 RKGGKGLLPVRWMAPESLKDG-VFTTSSDMWSFGVVLWEITSLAEQPY-QGLSNEQVLKF 266 Query: 225 IFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + + + P+ + DL++ + FNP R Sbjct: 267 VMDGGYLDQPDNCPERVT---------------------------DLMRMCWQFNPNMRP 299 Query: 285 TATQALK------MKYF 295 T + + F Sbjct: 300 TFLEIVNLLKDDLHPSF 316 >6FEX-A nrPDB Length = 321 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 117/323 (36%), Gaps = 62/323 (19%) Query: 10 KRYEKLDFLGEGQFATVYKAR----------------DKNTNQIVAIKKIKLGHRSEAKD 53 R + LGEGQF V+ K +VA+K + R +A Sbjct: 16 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL----RPDATK 71 Query: 54 GINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSL----- 107 L+E+K++ L PNII LL + ++ D+ME DL + + L Sbjct: 72 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 108 -------VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 ++ + G+ YL +HRDL N L+ EN +K+ADFG+++ Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 191 Query: 161 SFGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAE--LLLRVPFLPG 215 + + + + RW +L G + D+WA G L E +L R Sbjct: 192 NLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLMLCRAQPFGQ 249 Query: 216 DSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGL 275 +D ++ E G +Q + Y++ A L +L+ Sbjct: 250 LTD----EQVIENAGEFFRDQGRQV-----YLSRP-----------PACPQGLYELMLRC 289 Query: 276 FLFNPCARITATQALKMKYFSNR 298 + R +Q ++ + Sbjct: 290 WSRESEQRPPFSQL--HRFLAED 310 >1K9A-A nrPDB Length = 450 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 114/291 (39%), Gaps = 47/291 (16%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 K + L +G+G+F V + VA+K IK D + L E ++ + Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK-------NDATAQAFLAEASVMTQ 242 Query: 69 LSHPNIIGLLDAF-GHKSNISLVFDFM-ETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGL 125 L H N++ LL K + +V ++M + L ++ VL + + L + + Sbjct: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 EYL + +HRDL N+L+ E+ V K++DFGL K S T ++ +W APE L Sbjct: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPEALR 359 Query: 186 GARMYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + + D+W+ G +L E+ P D + R+ + + P Sbjct: 360 -EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP------ 412 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA---LKM 292 + D+++ + + R T Q L+ Sbjct: 413 ---------------------PAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >3DLS-A nrPDB Length = 335 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 113/301 (37%), Gaps = 39/301 (12%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEA---KDGINR 57 +A +++Y + LG G F V+ A DK N+ V +K IK E +D Sbjct: 15 LAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLG 74 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVI-IKDNSLVLTPSHIKA 116 EI +L + H NII +LD F ++ LV + + L++ D L Sbjct: 75 KVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASY 134 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 + + YL I+HRD+K N+++ E+ +KL DFG A YT T Sbjct: 135 IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT-FCGTI 193 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 Y APE+L G G ++MW++G L L+ +L E P Sbjct: 194 EYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPPYL- 246 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 +L+ L+ GL P R T + + + + Sbjct: 247 ---------------------------VSKELMSLVSGLLQPVPERRTTLEKLVTDPWVT 279 Query: 297 N 297 Sbjct: 280 Q 280 >3DTC-A nrPDB Length = 271 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 115/298 (38%), Gaps = 46/298 (15%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ + +G G F VY+A VA+K + + I +E K Sbjct: 2 LEIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTI-ENVRQEAK 58 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQ 123 L L HPNII L + N+ LV +F L ++ + P + + + + Sbjct: 59 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS--GKRIPPDILVNWAVQIAR 116 Query: 124 GLEYLHQHW---ILHRDLKPNNLLL--------DENGVLKLADFGLAKSFGSPNRAYTHQ 172 G+ YLH I+HRDLK +N+L+ N +LK+ DFGLA+ + + Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SA 174 Query: 173 VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 + APE++ + M+ G D+W+ G +L ELL G L Sbjct: 175 AGAYAWMAPEVIRAS-MFSKGSDVWSYGVLLWELLTGEVPFRGIDGL------------- 220 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 Y + +P I S + L++ + +P +R + T L Sbjct: 221 ----------AVAYGVAMNKLALP---IPSTCPEPFAKLMEDCWNPDPHSRPSFTNIL 265 >3TT0-A nrPDB Length = 382 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 121/310 (39%), Gaps = 61/310 (19%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQ-------IVAIKKIKLGHRSEAKDGINRTALRE 62 R LGEG F V A ++ VA+K +K S+A + + E Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISE 124 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV------------ 108 +++++ + H NII LL A + ++ ++ +L ++ Sbjct: 125 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNP 184 Query: 109 ---LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 L+ + + +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ Sbjct: 185 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 244 Query: 166 N---RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQ 221 + + ++ +W APE LF R+Y D+W+ G +L E+ PG Sbjct: 245 DYYKKTTNGRLPVKW-MAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV----P 298 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 + +F+ L P C+ Y+ +++ + P Sbjct: 299 VEELFKLLKEGHRMDKPSNCTNELYM-----------------------MMRDCWHAVPS 335 Query: 282 ARITATQALK 291 R T Q ++ Sbjct: 336 QRPTFKQLVE 345 >6GVJ-A nrPDB Length = 429 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 121/306 (39%), Gaps = 45/306 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 139 ISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 194 Query: 65 LLQELS--HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L II L D I +V + DL +K + P K+Y L Sbjct: 195 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK-SIDPWERKSYWKNML 253 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + QV T Y Sbjct: 254 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 312 Query: 181 PELLFG----------ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 PE + D+W++GCIL + ++Q++++ + Sbjct: 313 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 370 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 E ++PD+ DL D+++ +P RI+ + L Sbjct: 371 PNHEIEFPDIPE-----------------------KDLQDVLKCCLKRDPKQRISIPELL 407 Query: 291 KMKYFS 296 Y Sbjct: 408 AHPYVQ 413 >2W1I-A nrPDB Length = 326 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 111/283 (39%), Gaps = 27/283 (9%) Query: 13 EKLDFLGEGQFATVYKARDK----NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + L LG+G F +V R NT ++VA+KK+ + + R REI++L+ Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-----QHSTEEHLRDFEREIEILKS 98 Query: 69 LSHPNIIGLLDAFGHKS--NISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L H NI+ N+ L+ +++ L ++ + + + Y +G+ Sbjct: 99 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 158 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV---TRWYRAPE 182 EYL +HRDL N+L++ +K+ DFGL K Y + ++ APE Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 218 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 L ++ + V D+W+ G +L EL + + +G + Q Sbjct: 219 SLTESK-FSVASDVWSFGVVLYELFTYI-----EKSKSPPAEFMRMIGNDKQGQMIVFHL 272 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 + P D++ ++ + N R + Sbjct: 273 IELLKNNGRLPRPD------GCPDEIYMIMTECWNNNVNQRPS 309 >5HIE-A nrPDB Length = 302 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 110/293 (37%), Gaps = 39/293 (13%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 D + + +G G F TVYK + VA+K + + E+ Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQL--------QAFKNEV 78 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTL 122 +L++ H NI+ L + K +++V + E L + + T Sbjct: 79 GVLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTA 137 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTHQVVTRWYRA 180 QG++YLH I+HRDLK NN+ L E+ +K+ DFGLA KS S + + + + A Sbjct: 138 QGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 197 Query: 181 PELL--FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 PE++ Y D++A G +L EL+ ++ DQ+ Sbjct: 198 PEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQII--------------- 242 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 ++ + + L + S + L+ R Q L Sbjct: 243 -------FMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA 288 >2PL0-A nrPDB Length = 289 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 118/288 (40%), Gaps = 44/288 (15%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 + + + + ++ LG GQF V+ + VA+K +K G S L E Sbjct: 17 EWEVPRETLKLVERLGAGQFGEVWMGYYNG-HTKVAVKSLKQGSMSPD------AFLAEA 69 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKD-NSLVLTPSHIKAYMLMT 121 L+++L H ++ L + I ++ ++ME L +K + + LT + + Sbjct: 70 NLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQI 128 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---Y 178 +G+ ++ + +HRDL+ N+L+ + K+ADFGLA+ + YT + ++ + Sbjct: 129 AEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKW 186 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE + + + D+W+ G +L E++ PG ++ + + + + Sbjct: 187 TAPEAI-NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 245 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 P ++L L++ + P R T Sbjct: 246 P---------------------------EELYQLMRLCWKERPEDRPT 266 >3IO7-A nrPDB Length = 313 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 60/283 (21%), Positives = 111/283 (39%), Gaps = 27/283 (9%) Query: 13 EKLDFLGEGQFATVYKARDK----NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + L LG+G F +V R NT ++VA+KK+ + + R REI++L+ Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-----QHSTEEHLRDFEREIEILKS 85 Query: 69 LSHPNIIGLLDAFGHKS--NISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L H NI+ N+ L+ +++ L ++ + + + Y +G+ Sbjct: 86 LQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 145 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV---TRWYRAPE 182 EYL +HRDL N+L++ +K+ DFGL K Y + ++ APE Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 205 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 L ++ + V D+W+ G +L EL + + +G + Q Sbjct: 206 SLTESK-FSVASDVWSFGVVLYELFTYI-----EKSKSPPAEFMRMIGNDKQGQMIVFHL 259 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 + P D++ ++ + N R + Sbjct: 260 IELLKNNGRLPRPD------GCPDEIYMIMTECWNNNVNQRPS 296 >6BSD-A nrPDB Length = 876 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 67/329 (20%), Positives = 116/329 (35%), Gaps = 68/329 (20%) Query: 10 KRYEKLDFLGEGQFATVYKAR----------------DKNTNQIVAIKKIKLGHRSEAKD 53 R + LGEGQF V+ K +VA+K + R +A Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL----RPDATK 626 Query: 54 GINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDN------- 105 L+E+K++ L PNII LL + ++ D+ME DL + + Sbjct: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 686 Query: 106 -----------SLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLA 154 ++ + G+ YL +HRDL N L+ EN +K+A Sbjct: 687 EGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 746 Query: 155 DFGLAKSFGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAE--LLLR 209 DFG++++ + + + RW +L G + D+WA G L E +L R Sbjct: 747 DFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGK--FTTASDVWAFGVTLWEVLMLCR 804 Query: 210 VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLL 269 +D ++ E G +Q + Y++ A L Sbjct: 805 AQPFGQLTD----EQVIENAGEFFRDQGRQV-----YLSRP-----------PACPQGLY 844 Query: 270 DLIQGLFLFNPCARITATQALKMKYFSNR 298 +L+ + R +Q ++ + Sbjct: 845 ELMLRCWSRESEQRPPFSQL--HRFLAED 871 >3OMV-A nrPDB Length = 307 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 115/287 (40%), Gaps = 40/287 (13%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F TVYK + VA+K +K+ + + + E+ +L++ H NI+ L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQ---FQAFRNEVAVLRKTRHVNIL-L 96 Query: 78 LDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHR 136 + K N+++V + E L + + T QG++YLH I+HR Sbjct: 97 FMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHR 156 Query: 137 DLKPNNLLLDENGVLKLADFGLA--KSFGSPNRAYTHQVVTRWYRAPELL--FGARMYGV 192 D+K NN+ L E +K+ DFGLA KS S ++ + + APE++ + Sbjct: 157 DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSF 216 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSF 252 D+++ G +L EL+ ++ DQ+ ++ + + Sbjct: 217 QSDVYSYGIVLYELMTGELPYSHINNRDQII----------------------FMVGRGY 254 Query: 253 PGIPLHHIFSAAGDDLLDLIQGLFLFNPCAR------ITATQALKMK 293 L ++ + L+ R +++ + L+ Sbjct: 255 ASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS 301 >4H1J-A nrPDB Length = 293 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 53/276 (19%), Positives = 100/276 (36%), Gaps = 41/276 (14%) Query: 16 DFLGEGQFATVYKAR---DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 LGEG F VY+ K VA+K K + K+ + E +++ L HP Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEK----FMSEAVIMKNLDHP 85 Query: 73 NIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 +I+ L+ + ++ + L ++ N L + Y L + + YL Sbjct: 86 HIVKLIGIIEEE-PTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESI 144 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN--RAYTHQVVTRWYRAPELLFGARM 189 +HRD+ N+L+ +KL DFGL++ + +A ++ +W +PE + R Sbjct: 145 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKW-MSPESI-NFRR 202 Query: 190 YGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 + D+W + E+L + D + + + P + P Sbjct: 203 FTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP---------- 252 Query: 249 FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 L L+ + ++P R Sbjct: 253 -----------------PVLYTLMTRCWDYDPSDRP 271 >1FVR-A nrPDB Length = 327 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 123/301 (40%), Gaps = 53/301 (17%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIV--AIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + D +GEG F V KAR K + AIK++K A +R E+++L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMK----EYASKDDHRDFAGELEVLC 80 Query: 68 EL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSL---------------VLT 110 +L HPNII LL A H+ + L ++ +L ++ + + L+ Sbjct: 81 KLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLS 140 Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT 170 + + +G++YL Q +HRDL N+L+ EN V K+ADFGL++ + Sbjct: 141 SQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTM 200 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETL 229 ++ RW A E L +Y D+W+ G +L E++ G + ++E L Sbjct: 201 GRLPVRW-MAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMT----CAELYEKL 254 Query: 230 GTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 + P C D++ DL++ + P R + Q Sbjct: 255 PQGYRLEKPLNC-----------------------DDEVYDLMRQCWREKPYERPSFAQI 291 Query: 290 L 290 L Sbjct: 292 L 292 >5X5O-A nrPDB Length = 310 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 109/293 (37%), Gaps = 47/293 (16%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A V+ + + + G G F +VY+A+ + ++ VA+KK+ + Sbjct: 7 ASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-------------LKIEK 53 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNS-LVLTPSHIKAYML 119 E ++L LSH NII N +V ++ L I N + HI + Sbjct: 54 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 113 Query: 120 MTLQGLEYLHQH---WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 +G+ YLH ++HRDLK N+++ +GVLK+ DFG ++ V T Sbjct: 114 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM--SLVGTF 171 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 + APE++ + D ++ G +L E+L R G L + E Sbjct: 172 PWMAPEVIQSLPV-SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE--------- 221 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 I S+ +L+ + + R + Q Sbjct: 222 -----------------KNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQI 257 >6FER-A nrPDB Length = 309 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 116/308 (37%), Gaps = 57/308 (18%) Query: 13 EKLDFLGEGQFATVYKAR--------------DKNTNQ--IVAIKKIKLGHRSEAKDGIN 56 + LGEGQF V+ D + NQ +VA+K + R++A Sbjct: 12 TFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML----RADANKNAR 67 Query: 57 RTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSH-- 113 L+EIK++ L PNII LL + ++ ++ME DL + + + S Sbjct: 68 NDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 114 -------IKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN 166 +K G++YL +HRDL N L+ +N +K+ADFG++++ S + Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 187 Query: 167 RAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL- 222 + RW +L G + D+WA G L E + QL Sbjct: 188 YYRIQGRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT----FCQEQPYSQLS 241 Query: 223 -TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 ++ E G +Q T+ P I D + L+ + + Sbjct: 242 DEQVIENTGEFFRDQG--------RQTYLPQPAI--------CPDSVYKLMLSCWRRDTK 285 Query: 282 ARITATQA 289 R + + Sbjct: 286 NRPSFQEI 293 >1LUF-A nrPDB Length = 343 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 117/318 (36%), Gaps = 69/318 (21%) Query: 10 KRYEKLDFLGEGQFATVYKARDKN-----TNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 E + +GEG F V++AR +VA+K +K EA + RE Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK----EEASADMQADFQREAA 102 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKD------------------- 104 L+ E +PNI+ LL + L+F++M DL ++ Sbjct: 103 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRAR 162 Query: 105 ----NSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 L+ + G+ YL + +HRDL N L+ EN V+K+ADFGL++ Sbjct: 163 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 222 Query: 161 SFGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-LRVPFLPGD 216 + S + + RW PE +F R Y D+WA G +L E+ + G Sbjct: 223 NIYSADYYKADGNDAIPIRW-MPPESIFYNR-YTTESDVWAYGVVLWEIFSYGLQPYYGM 280 Query: 217 SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 + + + + + E P +L +L++ + Sbjct: 281 AHEEVIYYVRDGNILACPENCPL---------------------------ELYNLMRLCW 313 Query: 277 LFNPCARI---TATQALK 291 P R + + L+ Sbjct: 314 SKLPADRPSFCSIHRILQ 331 >4XUF-A nrPDB Length = 297 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 117/294 (39%), Gaps = 46/294 (15%) Query: 10 KRYEKLDFLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + E LG G F V A + VA+K +K +A + E+K Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK----EKADSSEREALMSELK 64 Query: 65 LLQEL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHI-------- 114 ++ +L SH NI+ LL A I L+F++ DL ++ + I Sbjct: 65 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 124 Query: 115 --------------KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 + +G+E+L +HRDL N+L+ V+K+ DFGLA+ Sbjct: 125 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR 184 Query: 161 SFGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR----VPFL 213 S + ++ +W APE LF +Y + D+W+ G +L E+ P + Sbjct: 185 DIMSDSNYVVRGNARLPVKW-MAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 242 Query: 214 PGDSDLDQLTRIFETLGTP---TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAA 264 P D++ +L + + P TEE + M S + + K P P F Sbjct: 243 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRK-RPSFPNLTSFLGC 295 >5A46-A nrPDB Length = 386 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 121/310 (39%), Gaps = 61/310 (19%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQ-------IVAIKKIKLGHRSEAKDGINRTALRE 62 R LGEG F V A ++ VA+K +K S+A + + E Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISE 95 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV------------ 108 +++++ + H NII LL A + ++ ++ +L ++ Sbjct: 96 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 155 Query: 109 ---LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 L+ + + +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ Sbjct: 156 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 215 Query: 166 N---RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQ 221 + + ++ +W APE LF R+Y D+W+ G +L E+ PG Sbjct: 216 DYYKKTTNGRLPVKW-MAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV----P 269 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 + +F+ L P C+ Y+ +++ + P Sbjct: 270 VEELFKLLKEGHRMDKPSNCTNELYM-----------------------MMRDCWHAVPS 306 Query: 282 ARITATQALK 291 R T Q ++ Sbjct: 307 QRPTFKQLVE 316 >5B2L-A nrPDB Length = 324 Score = 200 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 124/300 (41%), Gaps = 35/300 (11%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 ++ E L +G G V+K R + T ++A+K+++ RS K+ R + Sbjct: 12 YQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMR---RSGNKEENKRILMDLDV 68 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +L+ P I+ F +++ + + M T E + K + + + ++ Sbjct: 69 VLKSHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKA 128 Query: 125 LEYL-HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 L YL +H ++HRD+KP+N+LLDE G +KL DFG++ ++A T Y APE Sbjct: 129 LYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLV-DSKAKTRSAGCAAYMAPER 187 Query: 184 LF----GARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 + Y + D+W++G L EL P+ +D + LT++ + Sbjct: 188 IDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ----------- 236 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + P +P H FS D ++ + R + L+ + Sbjct: 237 -----------EEPPLLPGHMGFSG---DFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY 282 >5X02-A nrPDB Length = 347 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 117/294 (39%), Gaps = 46/294 (15%) Query: 10 KRYEKLDFLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + E LG G F V A + VA+K +K +A + E+K Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK----EKADSSEREALMSELK 103 Query: 65 LLQEL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHI-------- 114 ++ +L SH NI+ LL A I L+F++ DL ++ + I Sbjct: 104 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 163 Query: 115 --------------KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK 160 + +G+E+L +HRDL N+L+ V+K+ DFGLA+ Sbjct: 164 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLAR 223 Query: 161 SFGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR----VPFL 213 S + ++ +W APE LF +Y + D+W+ G +L E+ P + Sbjct: 224 DIMSDSNYVVRGNARLPVKW-MAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 281 Query: 214 PGDSDLDQLTRIFETLGTP---TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAA 264 P D++ +L + + P TEE + M S + + K P P F Sbjct: 282 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRK-RPSFPNLTSFLGC 334 >3GQL-A nrPDB Length = 326 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 121/310 (39%), Gaps = 61/310 (19%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQ-------IVAIKKIKLGHRSEAKDGINRTALRE 62 R LGEG F V A ++ VA+K +K S+A + + E Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISE 83 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV------------ 108 +++++ + H NII LL A + ++ ++ +L ++ Sbjct: 84 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 143 Query: 109 ---LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 L+ + + +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ Sbjct: 144 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHI 203 Query: 166 N---RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQ 221 + + ++ +W APE LF R+Y D+W+ G +L E+ PG Sbjct: 204 DYYKKTTNGRLPVKW-MAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV----P 257 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 + +F+ L P C+ Y+ +++ + P Sbjct: 258 VEELFKLLKEGHRMDKPSNCTNELYM-----------------------MMRDCWHAVPS 294 Query: 282 ARITATQALK 291 R T Q ++ Sbjct: 295 QRPTFKQLVE 304 >4HVI-A nrPDB Length = 314 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 115/281 (40%), Gaps = 28/281 (9%) Query: 15 LDFLGEGQFATVYKARDK----NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 + LG+G F +V R NT +VA+K+++ + +D REI++L+ L Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD-----FQREIQILKALH 69 Query: 71 HPNIIGLLDAFGHKSN--ISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 I+ + LV +++ + L ++ + L S + Y +G+EY Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEY 129 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV---TRWYRAPELL 184 L +HRDL N+L++ +K+ADFGLAK Y + ++ APE L Sbjct: 130 LGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESL 189 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 ++ D+W+ G +L EL D +G +E P + L Sbjct: 190 SD-NIFSRQSDVWSFGVVLYELFT-----YCDKSCSPSAEFLRMMG--SERDVPALSRLL 241 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 + + P A ++ +L++ + +P R + Sbjct: 242 ELLEEGQRLPAP-----PACPAEVHELMKLCWAPSPQDRPS 277 >4K33-A nrPDB Length = 325 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 121/309 (39%), Gaps = 61/309 (19%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQ-------IVAIKKIKLGHRSEAKDGINRTALREI 63 R LGEG F V A ++ VA+K +K +A D + E+ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLK----DDATDKDLSDLVSEM 92 Query: 64 KLLQEL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLV------------- 108 ++++ + H NII LL A + ++ ++ + +L ++ Sbjct: 93 EMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPE 152 Query: 109 --LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN 166 LT + + +G+EYL +HRDL N+L+ E+ V+K+ADFGLA+ + + Sbjct: 153 EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD 212 Query: 167 ---RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQL 222 ++ +W APE LF R+Y D+W+ G +L E+ PG + Sbjct: 213 YYKETTNGRLPVKW-MAPEALFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPG----IPV 266 Query: 223 TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCA 282 +F+ L P C+ DL +++ + P Sbjct: 267 EELFKLLKEGHRMDKPANCTH-----------------------DLYMIMRECWHAAPSQ 303 Query: 283 RITATQALK 291 R T Q ++ Sbjct: 304 RPTFKQLVE 312 >1BYG-A nrPDB Length = 278 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 114/291 (39%), Gaps = 47/291 (16%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 K + L +G+G+F V + VA+K IK D + L E ++ + Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIK-------NDATAQAFLAEASVMTQ 70 Query: 69 LSHPNIIGLLDAF-GHKSNISLVFDFM-ETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGL 125 L H N++ LL K + +V ++M + L ++ VL + + L + + Sbjct: 71 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 130 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLF 185 EYL + +HRDL N+L+ E+ V K++DFGL K S T ++ +W APE L Sbjct: 131 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD--TGKLPVKW-TAPEALR 187 Query: 186 GARMYGVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 + + D+W+ G +L E+ P D + R+ + + P Sbjct: 188 -EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP------ 240 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA---LKM 292 + ++++ + + R + Q L+ Sbjct: 241 ---------------------PAVYEVMKNCWHLDAAMRPSFLQLREQLEH 270 >3HMP-A nrPDB Length = 342 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 121/306 (39%), Gaps = 45/306 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 106 Query: 65 LLQELS--HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L II L D I +V + DL +K + P K+Y L Sbjct: 107 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK-SIDPWERKSYWKNML 165 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + QV T Y Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 224 Query: 181 PELLFG----------ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 PE + D+W++GCIL + ++Q++++ + Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 282 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 E ++PD+ DL D+++ +P RI+ + L Sbjct: 283 PNHEIEFPDIPE-----------------------KDLQDVLKCCLKRDPKQRISIPELL 319 Query: 291 KMKYFS 296 Y Sbjct: 320 AHPYVQ 325 >2WTK-B nrPDB Length = 373 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 77/351 (21%), Positives = 132/351 (37%), Gaps = 49/351 (13%) Query: 12 YEKLDFLGEGQF---ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR-EIKLLQ 67 YE L +G+G F TV AR K T + V +++I L EA T L+ E+ + + Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINL----EACSNEMVTFLQGELHVSK 65 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDL--EVIIKDNSLVLTPSHIKAYMLMTLQGL 125 +HPNI+ F + + +V FM ++I + I + L+ L Sbjct: 66 LFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKAL 125 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW-------- 177 +Y+H +HR +K +++L+ +G + L+ GL + + +VV + Sbjct: 126 DYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVL 183 Query: 178 -YRAPELLFGA-RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL--------TRIFE 227 + +PE+L + Y D+++VG EL L + + Sbjct: 184 PWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLD 243 Query: 228 TLGTPTEE------QWPDMCSLPDYVTFK-------SFPGIPLHHIFSAAGDDLLDLIQG 274 T P EE + L D +T P P H F ++ Sbjct: 244 TSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTF---SPHFHHFVEQ 300 Query: 275 LFLFNPCARITATQALKMKYFSN--RPGPTPGCQLPRPNCPVETLKEQSNP 323 NP AR +A+ L +F R +L RP P+ + + Sbjct: 301 CLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQ 351 >4XCU-A nrPDB Length = 300 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 116/301 (38%), Gaps = 52/301 (17%) Query: 10 KRYEKLDFLGEGQFATVYKAR-------DKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 R LGEG F V +A + VA+K +K A D + E Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK----DNASDKDLADLVSE 72 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLV------LTPSHI 114 +++++ + H NII LL + + ++ + + +L ++ L+ + Sbjct: 73 MEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVL 132 Query: 115 KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN---RAYTH 171 + +G++YL +HRDL N+L+ E+ V+K+ADFGLA+ + + Sbjct: 133 VSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNG 192 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLG 230 ++ +W APE LF R+Y D+W+ G +L E+ PG + + + E Sbjct: 193 RLPVKW-MAPEALFD-RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHR 250 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 P +L L++ + P R T Q + Sbjct: 251 MDRPPHCP---------------------------PELYGLMRECWHAAPSQRPTFKQLV 283 Query: 291 K 291 + Sbjct: 284 E 284 >4KIK-B nrPDB Length = 677 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 80/356 (22%), Positives = 138/356 (38%), Gaps = 38/356 (10%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V + ++ T + +AIK+ R E EI++++ L+H Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC----RQELSPRNRERWCLEIQIMRRLTH 76 Query: 72 PNIIGLLDAFGHKSNIS------LVFDFM-ETDLEVIIK--DNSLVLTPSHIKAYMLMTL 122 PN++ D N++ L ++ DL + +N L I + Sbjct: 77 PNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 136 Query: 123 QGLEYLHQHWILHRDLKPNNLLL---DENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L YLH++ I+HRDLKP N++L ++ + K+ D G AK + T V T Y Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGS-LCTSFVGTLQYL 195 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APELL + Y V VD W+ G + E + + Q D Sbjct: 196 APELLEQQK-YTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSED 254 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT------------AT 287 + + + +P ++ S + L +Q + +++P R T Sbjct: 255 LNGTVKFSSSLPYPN----NLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD 310 Query: 288 QALKMKYFSNRPGPTPGCQLPRPNC---PVETLKEQSNPALAIKRKRTEALEQGGL 340 L +K + G P +++LK + I + E L++ GL Sbjct: 311 DILNLK-LVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGL 365 >5AMN-A nrPDB Length = 299 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 123/285 (43%), Gaps = 33/285 (11%) Query: 14 KLDFLGEGQFATVYKA-----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 LGEG+F V KA + + VA+K +K A R L E +L++ Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK----ENASPSELRDLLSEFNVLKQ 82 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV---------LTPSHIKAYM 118 ++HP++I L A + L+ ++ + L ++++ V LT + ++ Sbjct: 83 VNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFA 142 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVT 175 QG++YL + ++HRDL N+L+ E +K++DFGL++ + ++ Sbjct: 143 WQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV 202 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTE 234 +W A E LF +Y D+W+ G +L E++ PG R+F L T Sbjct: 203 KW-MAIESLFD-HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP----ERLFNLLKTGHR 256 Query: 235 EQWPDMCSLPDY-VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLF 278 + PD CS Y + + + P D DL + + + Sbjct: 257 MERPDNCSEEMYRLMLQCWKQEPDKR--PVFADISKDL-EKMMVK 298 >5O0Y-A nrPDB Length = 579 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 114/305 (37%), Gaps = 42/305 (13%) Query: 23 FATVYKARDKNTNQIVAIKK--IKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDA 80 F+ VYKA D + VA+K + R E K+ ++ A RE ++ +EL HP I+ L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 81 FG-HKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW--ILHRD 137 F + V ++ E + +++ ++ ++ + L+YL++ I+H D Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYD 416 Query: 138 LKPNNLLLDEN---GVLKLADFGLAKSFGSPN-------RAYTHQVVTRWYRAPELL--- 184 LKP N+LL G +K+ DFGL+K + + T WY PE Sbjct: 417 LKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVG 476 Query: 185 FGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 VD+W+VG I + L PF S D L T+ TE Q+P Sbjct: 477 KEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQE--NTILKATEVQFPPK--- 531 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + I+ + RI Q Y + Sbjct: 532 ------------------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSV 573 Query: 304 GCQLP 308 P Sbjct: 574 STSSP 578 >6E4F-A nrPDB Length = 290 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 26/277 (9%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + K L LG GQF V + + VAIK IK G SE + + E K+ Sbjct: 27 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE------FIEEAKV 79 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 + LSH ++ L + I ++ ++M L +++ + + Sbjct: 80 MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 139 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAP 181 +EYL LHRDL N L+++ GV+K++DFGL++ YT V +++ + P Sbjct: 140 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTSSVGSKFPVRWSPP 197 Query: 182 ELLFGARMYGVGVDMWAVGCILAEL--LLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 E+L ++ + D+WA G ++ E+ L ++P+ ++ + I + L P Sbjct: 198 EVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHIAQGL----RLYRPH 251 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 + S Y S H L+ + Sbjct: 252 LASEKVYTIMYSC----WHEKADE-RPTFKILLSNIL 283 >4XI2-A nrPDB Length = 446 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 114/277 (41%), Gaps = 26/277 (9%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + K L LG GQF V + + VAIK I+ G SE + + E K+ Sbjct: 183 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMSEDE------FIEEAKV 235 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 + LSH ++ L + I ++ ++M L +++ + + Sbjct: 236 MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 295 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAP 181 +EYL LHRDL N L+++ GV+K++DFGL++ YT V +++ + P Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDD--EYTSSVGSKFPVRWSPP 353 Query: 182 ELLFGARMYGVGVDMWAVGCILAEL--LLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 E+L ++ + D+WA G ++ E+ L ++P+ ++ + I + L P Sbjct: 354 EVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHIAQGL----RLYRPH 407 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 + S Y S H L+ + Sbjct: 408 LASERVYTIMYSC----WHEKADE-RPSFKILLSNIL 439 >5HVK-A nrPDB Length = 315 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 130/321 (40%), Gaps = 50/321 (15%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG+G F K + T +++ +K++ + RT L+E+K+++ L HPN++ Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKEL-----IRFDEETQRTFLKEVKVMRCLEHPNVL 74 Query: 76 GLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 + ++ + ++++ L IIK S ++ G+ YLH I+ Sbjct: 75 KFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNII 134 Query: 135 HRDLKPNNLLLDENGVLKLADFGLA-------------KSFGSPNRAYT-HQVVTRWYRA 180 HR+L +N L+ EN + +ADFGLA +S P+R V ++ A Sbjct: 135 HRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMA 194 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE++ G R Y VD+++ G +L E++ RV ++D D L R + Sbjct: 195 PEMING-RSYDEKVDVFSFGIVLCEIIGRV-----NADPDYLPRTMD-----------FG 237 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 ++ ++ P P F DL +P R + + L+ + Sbjct: 238 LNVRGFLDRYCPPNCPPS--FFPITVRCCDL-------DPEKRPSFVK-LEH-WLETLRM 286 Query: 301 PTPG--CQLPRPNCPVETLKE 319 G P+ E Sbjct: 287 HLAGHLPLGPQLEQLDRGFWE 307 >2PSQ-A nrPDB Length = 370 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 121/310 (39%), Gaps = 61/310 (19%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQ-------IVAIKKIKLGHRSEAKDGINRTALRE 62 + LGEG F V A ++ VA+K +K +A + + E Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK----DDATEKDLSDLVSE 136 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV------------ 108 +++++ + H NII LL A + ++ ++ +L ++ Sbjct: 137 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVP 196 Query: 109 ---LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 +T + + +G+EYL +HRDL N+L+ EN V+K+ADFGLA+ + Sbjct: 197 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 256 Query: 166 N---RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQ 221 + + ++ +W APE LF R+Y D+W+ G ++ E+ PG Sbjct: 257 DYYKKTTNGRLPVKW-MAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPG----IP 310 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 + +F+ L P C+ Y+ +++ + P Sbjct: 311 VEELFKLLKEGHRMDKPANCTNELYM-----------------------MMRDCWHAVPS 347 Query: 282 ARITATQALK 291 R T Q ++ Sbjct: 348 QRPTFKQLVE 357 >5O2B-A nrPDB Length = 285 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 122/303 (40%), Gaps = 42/303 (13%) Query: 7 SRAKRYEKLDF-LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 S + R+ K D LG G F TVYK D T VA +++ ++A+ + E ++ Sbjct: 12 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ---QRFKEEAEM 68 Query: 66 LQELSHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+ L HPNI+ D++ K I LV + M + V+ P ++++ Sbjct: 69 LKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQI 128 Query: 122 LQGLEYLHQHW--ILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L+GL++LH I+HRDLK +N+ + G +K+ D GLA + + T + Sbjct: 129 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT--SFAKSVIGTPEF 186 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+ Y VD++A G + E+ P+ + ++ Sbjct: 187 MAPEMY--EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV------------ 232 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 GI ++ ++I+G N R++ L +F+ Sbjct: 233 --------------TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 Query: 298 RPG 300 G Sbjct: 279 DTG 281 >5TUR-A nrPDB Length = 404 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 114/304 (37%), Gaps = 43/304 (14%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQE 68 +Y+ LG G F +VY + N VAIK ++ S+ + N T E+ LL++ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 69 LSHPN--IIGLLDAFGHKSNISLVFDFMET--DLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 187 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 245 Query: 125 LEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + + H +LHRD+K N+L+D G LKL DFG + YT TR Y PE Sbjct: 246 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 303 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + R +G +W++G +L +++ D ++ + F Sbjct: 304 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR-------------- 349 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + LI+ P R T + + + P Sbjct: 350 --------------------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 389 Query: 304 GCQL 307 ++ Sbjct: 390 TAEI 393 >3BGP-A nrPDB Length = 333 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 114/304 (37%), Gaps = 43/304 (14%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQE 68 +Y+ LG G F +VY + N VAIK ++ S+ + N T E+ LL++ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 69 LSHPN--IIGLLDAFGHKSNISLVFDFMET--DLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 174 Query: 125 LEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + + H +LHRD+K N+L+D G LKL DFG + YT TR Y PE Sbjct: 175 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 232 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + R +G +W++G +L +++ D ++ + F Sbjct: 233 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR-------------- 278 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + LI+ P R T + + + P Sbjct: 279 --------------------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 318 Query: 304 GCQL 307 ++ Sbjct: 319 TAEI 322 >2OGV-A nrPDB Length = 317 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 112/297 (37%), Gaps = 52/297 (17%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI-----VAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + LG G F V +A + VA+K +K ++ K+ + E+K++ Sbjct: 41 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA----LMSELKIMS 96 Query: 68 EL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDN---------SLVLTPSHIKA 116 L H NI+ LL A H + ++ ++ DL ++ L + Sbjct: 97 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLH 156 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY---THQV 173 + QG+ +L +HRD+ N+LL V K+ DFGLA+ + + ++ Sbjct: 157 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARL 216 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTP 232 +W APE +F +Y V D+W+ G +L E+ + PG + ++ + Sbjct: 217 PVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM 274 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 + + A ++ ++Q + P R T Q Sbjct: 275 AQPAF--------------------------APKNIYSIMQACWALEPTHRPTFQQI 305 >4Y93-A nrPDB Length = 446 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 57/236 (24%), Positives = 105/236 (44%), Gaps = 17/236 (7%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 + K L LG GQF V + + VAIK IK G SE + + E K+ Sbjct: 184 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE------FIEEAKV 236 Query: 66 LQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 + LSH ++ L + I ++ ++M L +++ + + Sbjct: 237 MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEA 296 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAP 181 +EYL LHRDL N L+++ GV+K++DFG+ + YT +++ + +P Sbjct: 297 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDD--EYTSSTGSKFPVKWASP 354 Query: 182 ELLFGARMYGVGVDMWAVGCILAEL--LLRVPFLPGDSDLDQLTRIFETLGTPTEE 235 E+L ++ + D+WA G ++ E+ L ++P+ ++ + I + L P Sbjct: 355 EVLMYSK-FSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHIAQGLRLPRPH 408 >5O2C-A nrPDB Length = 380 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 122/303 (40%), Gaps = 42/303 (13%) Query: 7 SRAKRYEKLDF-LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 S + R+ K D LG G F TVYK D T VA +++ ++A+ + E ++ Sbjct: 21 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ---QRFKEEAEM 77 Query: 66 LQELSHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+ L HPNI+ D++ K I LV + M + V+ P ++++ Sbjct: 78 LKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQI 137 Query: 122 LQGLEYLHQHW--ILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 L+GL++LH I+HRDLK +N+ + G +K+ D GLA + + T + Sbjct: 138 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT--SFAKSVIGTPEF 195 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQW 237 APE+ Y VD++A G + E+ P+ + ++ Sbjct: 196 MAPEMY--EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKV------------ 241 Query: 238 PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 GI ++ ++I+G N R++ L +F+ Sbjct: 242 --------------TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 Query: 298 RPG 300 G Sbjct: 288 DTG 290 >2ZMD-A nrPDB Length = 390 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 120/306 (39%), Gaps = 45/306 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 106 Query: 65 LLQELS--HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L II L D I +V + DL +K + P K+Y L Sbjct: 107 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKK-SIDPWERKSYWKNML 165 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + QV Y Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMP 224 Query: 181 PELLFG----------ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 PE + D+W++GCIL + ++Q++++ + Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 282 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 E ++PD+ DL D+++ +P RI+ + L Sbjct: 283 PNHEIEFPDIPE-----------------------KDLQDVLKCCLKRDPKQRISIPELL 319 Query: 291 KMKYFS 296 Y Sbjct: 320 AHPYVQ 325 >2HK5-A nrPDB Length = 270 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 113/265 (42%), Gaps = 22/265 (8%) Query: 13 EKLDFLGEGQFATVYKA-RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + LG GQF V+ A +K+T VA+K +K G S L E +++ L H Sbjct: 18 KLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS------VEAFLAEANVMKTLQH 69 Query: 72 PNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLH 129 ++ L K I ++ +FM + L +K D + + +G+ ++ Sbjct: 70 DKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFG 186 Q +HRDL+ N+L+ + V K+ADFGLA+ + YT + ++ + APE + Sbjct: 129 QRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAI-N 185 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + + D+W+ G +L E++ PG S+ + + + P E P+ Sbjct: 186 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL---Y 242 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLD 270 + + + P +LD Sbjct: 243 NIMMRCWKNRPEERPTFEYIQSVLD 267 >5AP3-A nrPDB Length = 313 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 121/306 (39%), Gaps = 45/306 (14%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + + + Y L +G G + V++ ++ QI AIK + L EA + + EI Sbjct: 23 MSVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNL---EEADNQTLDSYRNEIA 78 Query: 65 LLQELS--HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTL 122 L +L II L D I +V + DL +K + P K+Y L Sbjct: 79 YLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKK-SIDPWERKSYWKNML 137 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVTRWYRA 180 + + +HQH I+H DLKP N L+ +G+LKL DFG+A + QV T Y Sbjct: 138 EAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 196 Query: 181 PELLFG----------ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 PE + D+W++GCIL + ++Q++++ + Sbjct: 197 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 254 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 E ++PD+ DL D+++ +P RI+ + L Sbjct: 255 PNHEIEFPDIPE-----------------------KDLQDVLKCCLKRDPKQRISIPELL 291 Query: 291 KMKYFS 296 Y Sbjct: 292 AHPYVQ 297 >4RC3-A nrPDB Length = 289 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 114/304 (37%), Gaps = 43/304 (14%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQE 68 +Y+ LG G F +VY + N VAIK ++ S+ + N T E+ LL++ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 69 LSHPN--IIGLLDAFGHKSNISLVFDFMET--DLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 130 Query: 125 LEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 + + H +LHRD+K N+L+D G LKL DFG + YT TR Y PE Sbjct: 131 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 188 Query: 184 LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 + R +G +W++G +L +++ D ++ + F Sbjct: 189 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR-------------- 234 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + LI+ P R T + + + P Sbjct: 235 --------------------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 274 Query: 304 GCQL 307 ++ Sbjct: 275 TAEI 278 >3BEA-A nrPDB Length = 333 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 115/301 (38%), Gaps = 56/301 (18%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI-----VAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + LG G F V +A + VA+K +K ++ K+ + E+K++ Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA----LMSELKIMS 104 Query: 68 EL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVL-------------TPS 112 L H NI+ LL A H + ++ ++ DL ++ S VL + Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTR 164 Query: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--- 169 + + QG+ +L +HRD+ N+LL V K+ DFGLA+ + + Sbjct: 165 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 224 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFET 228 ++ +W APE +F +Y V D+W+ G +L E+ + PG + ++ + Sbjct: 225 NARLPVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKD 282 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 + + A ++ ++Q + P R T Q Sbjct: 283 GYQMAQPAF--------------------------APKNIYSIMQACWALEPTHRPTFQQ 316 Query: 289 A 289 Sbjct: 317 I 317 >5U6B-A nrPDB Length = 307 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 71/322 (22%), Positives = 121/322 (37%), Gaps = 50/322 (15%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTN--QIVAIKKIKLGHRSEAKDGINRTALR 61 DV + LGEG+F V + + + VA+K +K+ + ++ L Sbjct: 17 DVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSE---LEDFLS 73 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSN------ISLVFDFME-TDLEVIIK-----DNSLVL 109 E ++E HPN++ L+ S ++ FM+ DL + D + L Sbjct: 74 EAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYL 133 Query: 110 TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY 169 + +M G+EYL +HRDL N +L+EN + +ADFGL+K + + Sbjct: 134 PTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYR 193 Query: 170 THQVV--TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIF 226 ++ + A E L R+Y D+W+ G + E+ PG + + I+ Sbjct: 194 QGRIAKMPVKWIAIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSE----IY 248 Query: 227 ETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 + L + P C D L L+ + NP R + Sbjct: 249 DYLRQGNRLKQPADC-----------------------LDGLYALMSRCWELNPQDRPSF 285 Query: 287 TQALKMKYFSNRPGPTPGCQLP 308 T+ + N P Q P Sbjct: 286 TELRED--LENTLKALPPAQEP 305 >3I81-A nrPDB Length = 315 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 56/304 (18%), Positives = 112/304 (36%), Gaps = 50/304 (16%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQ-----IVAIKKIKLGHRSEAKDGINRT 58 + + ++ LG+G F VY+ K + VAIK + + Sbjct: 12 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRER----IE 67 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIK------DNSLVLTP 111 L E +++E + +++ LL ++ + M DL+ ++ +N+ VL P Sbjct: 68 FLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAP 127 Query: 112 SHIKAYML---MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 + + G+ YL+ + +HRDL N ++ E+ +K+ DFG+ + + Sbjct: 128 PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY 187 Query: 169 YTHQVV--TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVP-FLPGDSDLDQLTRI 225 + +PE L ++ D+W+ G +L E+ G S+ L + Sbjct: 188 RKGGKGLLPVRWMSPESLKDG-VFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 246 Query: 226 FETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 E + PDM L +L++ + +NP R + Sbjct: 247 MEGGLLDKPDNCPDM---------------------------LFELMRMCWQYNPKMRPS 279 Query: 286 ATQA 289 + Sbjct: 280 FLEI 283 >3CJF-A nrPDB Length = 309 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 119/306 (38%), Gaps = 55/306 (17%) Query: 10 KRYEKLDFLGEGQFATVYKA----RDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 R LG G F V +A DK T + VA+K +K G A +R + E+K Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEG----ATHSEHRALMSELK 82 Query: 65 LLQELSHP-NIIGLLDAFGHKS-NISLVFDFME-TDLEVIIKDNSLVLTP---------- 111 +L + H N++ LL A + ++ +F + +L ++ P Sbjct: 83 ILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLT 142 Query: 112 -SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG-SPNRAY 169 H+ Y +G+E+L +HRDL N+LL E V+K+ DFGLA+ P+ Sbjct: 143 LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVR 202 Query: 170 THQVVTRW-YRAPELLFGARMYGVGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIF 226 + APE +F R+Y + D+W+ G +L E+ P+ D + R+ Sbjct: 203 KGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK 261 Query: 227 ETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 E PDY T ++ + + P R T Sbjct: 262 EGTRM----------RAPDYTT-----------------PEMYQTMLDCWHGEPSQRPTF 294 Query: 287 TQALKM 292 ++ ++ Sbjct: 295 SELVEH 300 >3KRL-A nrPDB Length = 335 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 113/303 (37%), Gaps = 58/303 (19%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI-----VAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + LG G F V +A + VA+K +K ++ K+ + E+K++ Sbjct: 49 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA----LMSELKIMS 104 Query: 68 EL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLV---------------LT 110 L H NI+ LL A H + ++ ++ DL ++ L+ Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLS 164 Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY- 169 + + QG+ +L +HRD+ N+LL V K+ DFGLA+ + + Sbjct: 165 SRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIV 224 Query: 170 --THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIF 226 ++ +W APE +F +Y V D+W+ G +L E+ + PG + ++ Sbjct: 225 KGNARLPVKW-MAPESIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLV 282 Query: 227 ETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 + + + A ++ ++Q + P R T Sbjct: 283 KDGYQMAQPAF--------------------------APKNIYSIMQACWALEPTHRPTF 316 Query: 287 TQA 289 Q Sbjct: 317 QQI 319 >5UIU-A nrPDB Length = 323 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 60/211 (28%), Positives = 100/211 (47%), Gaps = 10/211 (4%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 +GEG F VYK NT VA+KK+ + + + +EIK++ + H N++ Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKL-AAMVDITTEELKQQFDQEIKVMAKCQHENLVE 110 Query: 77 LLDAFGHKSNISLVFDFMETD--LEVI-IKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 LL ++ LV+ +M L+ + D + L+ G+ +LH++ Sbjct: 111 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQ-VVTRWYRAPELLFGARMYG 191 +HRD+K N+LLDE K++DFGLA+ S T + V T Y APE L G Sbjct: 171 IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE--IT 228 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQL 222 D+++ G +L E++ +P + + L Sbjct: 229 PKSDIYSFGVVLLEIITGLPAVDEHREPQLL 259 >3BBT-B nrPDB Length = 328 Score = 193 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 61/310 (19%), Positives = 112/310 (36%), Gaps = 27/310 (8%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIV----AIKKIKLGHRSEAKDGINRTALREI 63 + +++ LG G F TVYK + V AIK + +A N + E Sbjct: 13 KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA----NVEFMDEA 68 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + HP+++ LL + I LV M L + ++ + + + + Sbjct: 69 LIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIA 127 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV--TRWYRA 180 +G+ YL + ++HRDL N+L+ +K+ DFGLA+ + Y + A Sbjct: 128 KGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 E + R + D+W+ G + EL+ P+ D I + L P Sbjct: 188 LECIH-YRKFTHQSDVWSYGVTIWELMTFGGKPY-----DGIPTREIPDLLEKGERLPQP 241 Query: 239 DMCSLPDYVTFKSF------PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKM 292 +C++ Y+ + + D Q + R+ Sbjct: 242 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD-PQRYLVIQGDDRMKLPSPNDS 300 Query: 293 KYFSNRPGPT 302 K+F N Sbjct: 301 KFFQNLLDEE 310 >4Y83-A nrPDB Length = 332 Score = 193 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 104/281 (37%), Gaps = 33/281 (11%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 DF+ G F VY A+D T + +A K I + + +++ H NI Sbjct: 79 DFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD----------VEIQACFRHENIA 128 Query: 76 GLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 L A + L + E + ++ + I L+GL++LH ++H Sbjct: 129 ELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIH 188 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVD 195 D+KP+N++ + L DFGL+ T Y +PE++ R + D Sbjct: 189 HDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHSTKAD 246 Query: 196 MWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGI 255 ++++G L + P P +++P + P Y+ Sbjct: 247 IYSLGATLIHMQTGTP--------------------PWVKRYPR-SAYPSYLYIIHKQAP 285 Query: 256 PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 PL I + +LI+ NP R A LK + + Sbjct: 286 PLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN 326 >5EG3-A nrPDB Length = 334 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 119/310 (38%), Gaps = 61/310 (19%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQ-------IVAIKKIKLGHRSEAKDGINRTALRE 62 + LGEG F V A ++ VA+K +K +A + + E Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLK----DDATEKDLSDLVSE 90 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV------------ 108 +++++ + H NII LL A + ++ + +L ++ Sbjct: 91 MEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVP 150 Query: 109 ---LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 +T + + +G+EYL +HRDL N+L+ EN V+K+ADFGLA+ + Sbjct: 151 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNI 210 Query: 166 N---RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQ 221 + ++ +W APE LF R+Y D+W+ G ++ E+ PG Sbjct: 211 DFFKETTNGRLPVKW-MAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPG----IP 264 Query: 222 LTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 + +F+ L P C+ Y+ +++ + P Sbjct: 265 VEELFKLLKEGHRMDKPANCTNELYM-----------------------MMRDCWHAVPS 301 Query: 282 ARITATQALK 291 R T Q ++ Sbjct: 302 QRPTFKQLVE 311 >4PWN-A nrPDB Length = 274 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 124/297 (41%), Gaps = 41/297 (13%) Query: 10 KRYEKLDF-LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 R+ K D +G G F TVYK D T VA +++ ++++ + E ++L+ Sbjct: 9 GRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSE---RQRFKEEAEMLKG 65 Query: 69 LSHPNIIGLLDAFGH----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L HPNI+ D++ K I LV + M + V+ ++++ L+G Sbjct: 66 LQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKG 125 Query: 125 LEYLHQHW--ILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 L++LH I+HRDLK +N+ + G +K+ D GLA + A + T + AP Sbjct: 126 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFA-KSVIGTPEFMAP 184 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 E+ Y VD++A G + E+ P+ S+ +I+ + + + D Sbjct: 185 EMY--EEKYDESVDVYAFGMCMLEMATSEYPY----SECQNAAQIYRRVTSGVKPASFDK 238 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 ++P ++ ++I+G N R + L +F Sbjct: 239 VAIP----------------------EVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5FM2-A nrPDB Length = 355 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 123/299 (41%), Gaps = 47/299 (15%) Query: 14 KLDFLGEGQFATVYKA-----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 LGEG+F V KA + + VA+K +K A R L E +L++ Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK----ENASPSELRDLLSEFNVLKQ 123 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLV------------------- 108 ++HP++I L A + L+ ++ + L ++++ V Sbjct: 124 VNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHP 183 Query: 109 ----LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS 164 LT + ++ QG++YL + ++HRDL N+L+ E +K++DFGL++ Sbjct: 184 DERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE 243 Query: 165 PNRAYT---HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLD 220 + ++ +W A E LF +Y D+W+ G +L E++ PG Sbjct: 244 EDSYVKRSQGRIPVKW-MAIESLFD-HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP-- 299 Query: 221 QLTRIFETLGTPTEEQWPDMCSLPDY-VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLF 278 R+F L T + PD CS Y + + + P D DL + + + Sbjct: 300 --ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKR--PVFADISKDL-EKMMVK 353 >4M7I-A nrPDB Length = 299 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 70/290 (24%), Positives = 124/290 (42%), Gaps = 36/290 (12%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +E + LG G F V++A++K + AIK+I+L +R A++ + +RE+K L +L Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV----MREVKALAKLE 61 Query: 71 HPNIIGLLDAFGHKS------------NISLVFDFMETDLEVIIKDNSLVLTPSH---IK 115 HP I+ +A+ K+ + + + + + Sbjct: 62 HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA------- 168 L + +E+LH ++HRDLKP+N+ + V+K+ DFGL + Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 169 -----YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLT 223 +T QV T+ Y +PE + G Y VD++++G IL ELL PF + LT Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHG-NSYSHKVDIFSLGLILFELL--YPFSTQMERVRTLT 238 Query: 224 RIFETLGTP--TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDL 271 + P T++ + + D ++ +I A + LD Sbjct: 239 DVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDF 288 >3MY0-A nrPDB Length = 305 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 117/314 (37%), Gaps = 50/314 (15%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ A++ ++ +G+G++ V++ + VA+K ++ RE ++ Sbjct: 4 RTVARQVALVECVGKGRYGEVWRGLWH--GESVAVKIFS--------SRDEQSWFRETEI 53 Query: 66 LQE--LSHPNIIGLLDAFGHKSN----ISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYM 118 L H NI+G + + N + L+ + E L ++ L P Sbjct: 54 YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ--RQTLEPHLALRLA 111 Query: 119 LMTLQGLEYLH--------QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY- 169 + GL +LH + I HRD K N+L+ N +AD GLA + Sbjct: 112 VSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLD 171 Query: 170 ---THQVVTRWYRAPELLFGARMYG-----VGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 +V T+ Y APE+L D+WA G +L E+ R Sbjct: 172 IGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRT----------I 221 Query: 222 LTRIFETLGTPTEEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFL 277 + I E P + P+ S D + P IP L +++ + Sbjct: 222 VNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWY 281 Query: 278 FNPCARITATQALK 291 NP AR+TA + K Sbjct: 282 PNPSARLTALRIKK 295 >4R7H-A nrPDB Length = 343 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 113/310 (36%), Gaps = 65/310 (20%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQI-----VAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + LG G F V +A + VA+K +K ++ K+ + E+K++ Sbjct: 53 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA----LMSELKIMS 108 Query: 68 EL-SHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDN-------------------- 105 L H NI+ LL A H + ++ ++ DL ++ Sbjct: 109 HLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDK 168 Query: 106 --SLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG 163 L + + QG+ +L +HRD+ N+LL V K+ DFGLA+ Sbjct: 169 EDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIM 228 Query: 164 SPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDL 219 + + ++ +W APE +F + +Y V D+W+ G +L E+ + PG Sbjct: 229 NDSNYIVKGNARLPVKW-MAPESIFDS-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVN 286 Query: 220 DQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN 279 + ++ + + + A ++ ++Q + Sbjct: 287 SKFYKLVKDGYQMAQPAF--------------------------APKNIYSIMQACWALE 320 Query: 280 PCARITATQA 289 P R T Q Sbjct: 321 PTHRPTFQQI 330 >3G0E-A nrPDB Length = 336 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 62/311 (19%), Positives = 109/311 (35%), Gaps = 62/311 (19%) Query: 10 KRYEKLDFLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 R LG G F V +A + VA+K +K ++ + E+K Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA----LMSELK 101 Query: 65 LLQEL-SHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVL------------- 109 +L L +H NI+ LL A ++ ++ DL ++ Sbjct: 102 VLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDD 161 Query: 110 ----TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP 165 + ++ +G+ +L +HRDL N+LL + K+ DFGLA+ + Sbjct: 162 ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND 221 Query: 166 NRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDS-DLD 220 + ++ +W APE +F +Y D+W+ G L EL PG D Sbjct: 222 SNYVVKGNARLPVKW-MAPESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSK 279 Query: 221 QLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNP 280 I E + E P ++ D+++ + +P Sbjct: 280 FYKMIKEGFRMLSPEHAPA---------------------------EMYDIMKTCWDADP 312 Query: 281 CARITATQALK 291 R T Q ++ Sbjct: 313 LKRPTFKQIVQ 323 >4HZS-A nrPDB Length = 341 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 101/281 (35%), Gaps = 22/281 (7%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKLL 66 K L+ LG+G F V + + VA+K +K S+ + +RE+ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD--DFIREVNAM 69 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L H N+I L + +V + L ++ + + Y + +G+ Sbjct: 70 HSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 128 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPE 182 YL +HRDL NLLL ++K+ DFGL ++ + Y H+ V + APE Sbjct: 129 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 188 Query: 183 LLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRI-FETLGTPTEEQWPDM 240 L R + D W G L E+ G + L +I E P E P Sbjct: 189 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 V + + P L D L P Sbjct: 248 I---YNVMVQCWAHKPEDR---PTFVALRDF---LLEAQPT 279 >5TQX-A nrPDB Length = 655 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 76/362 (20%), Positives = 140/362 (38%), Gaps = 40/362 (11%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V + + + +AIK +L ++ ++ EI+++++L+H Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRE----RWCHEIQIMKKLNH 65 Query: 72 PNIIGLLDAFGHKSNIS-----LVFDFM-ETDLEVIIK--DNSLVLTPSHIKAYMLMTLQ 123 N++ D + + L ++ DL ++ +N L S I + + Sbjct: 66 ANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGS 125 Query: 124 GLEYLHQHWILHRDLKPNNLLL-DENGVL--KLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 G+ YLH++ I+HRDLKP N++L D G + K+ D G AK T V T Y A Sbjct: 126 GIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQ-GELCTEFVGTLQYLA 184 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 PE LF + Y VD W+ G ++ E + + +M Sbjct: 185 PE-LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEM 243 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCAR-----ITATQ-----AL 290 + + P + S + + + +Q + ++P R +T Q + Sbjct: 244 SGEVRFSSHLPQPN----SLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLM 299 Query: 291 KM------KYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL---P 341 + N L P+ + +L+ + I E L + G+ P Sbjct: 300 DHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGISLDP 359 Query: 342 KK 343 +K Sbjct: 360 RK 361 >3ZBF-A nrPDB Length = 322 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 108/297 (36%), Gaps = 53/297 (17%) Query: 10 KRYEKLDFLGEGQFATVYKAR-----DKNTNQI-VAIKKIKLGHRSEAKDGINRTALREI 63 ++ LG G F VY+ + +I VA+K +K G + K L+E Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEK----IEFLKEA 88 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKD------NSLVLTPSHIKA 116 L+ + +HPNI+ L ++ + ME DL ++ +LT + Sbjct: 89 HLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 148 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLL-----DENGVLKLADFGLAKSFGSPNRAYTH 171 + +G YL + +HRDL N L+ ++K+ DFGLA+ + Sbjct: 149 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 208 Query: 172 QVV--TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFET 228 + APE L ++ D+W+ G ++ E+L P S+LD L Sbjct: 209 GEGLLPVRWMAPESLMDG-IFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLN----- 262 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 YV P DDL +L+ + P R T Sbjct: 263 -----------------YVQTGGRLEPP-----RNCPDDLWNLMTQCWAQEPDQRPT 297 >3QA8-A nrPDB Length = 676 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 103/256 (40%), Gaps = 18/256 (7%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 +E + LG G F V + ++T + VAIK+ R E EI+++++L+H Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQC----RQELSPKNRERWCLEIQIMKKLNH 71 Query: 72 PNIIGLLDAFGHKSNI------SLVFDFMET-DLEVIIK--DNSLVLTPSHIKAYMLMTL 122 PN++ + + L ++ E DL + +N L I+ + Sbjct: 72 PNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDIS 131 Query: 123 QGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 L YLH++ I+HRDLKP N++L + + K+ D G AK T V T Y Sbjct: 132 SALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQ-GELCTEFVGTLQYL 190 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 APELL + Y V VD W+ G + E + + Q + D Sbjct: 191 APELLEQ-KKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDD 249 Query: 240 MCSLPDYVTFKSFPGI 255 + + + P Sbjct: 250 LTGAVKFSSVLPTPNH 265 >3C1X-A nrPDB Length = 373 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 56/234 (23%), Positives = 97/234 (41%), Gaps = 15/234 (6%) Query: 16 DFLGEGQFATVYKAR---DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + +G G F VY + A+K + G L E ++++ SHP Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI----GEVSQFLTEGIIMKDFSHP 150 Query: 73 NIIGLLDAFGH-KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 N++ LL + + +V +M+ DL I++ + T + + L +G+++L Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLAS 210 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN----RAYTHQVVTRWYRAPELLFG 186 +HRDL N +LDE +K+ADFGLA+ T + + A E L Sbjct: 211 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ- 269 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 + + D+W+ G +L EL+ P P + D + + E PD Sbjct: 270 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD 323 >5VD3-A nrPDB Length = 311 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 107/287 (37%), Gaps = 36/287 (12%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70 +++L LG G + V+K R K ++ A+K+ R L E+ +++ Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARK---LAEVGSHEKVGQ 115 Query: 71 HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 HP + L A+ + L + L+ + L + + Y+ TL L +LH Sbjct: 116 HPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHS 175 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY 190 ++H D+KP N+ L G KL DFGL G+ + Y APELL G+ Y Sbjct: 176 QGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE-GDPRYMAPELLQGS--Y 232 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 250 G D++++G + E+ + G QL + Sbjct: 233 GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQ-------------------------- 266 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 G + +L ++ + +P R TA L + Sbjct: 267 ---GYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >5TOS-A nrPDB Length = 395 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 117/308 (37%), Gaps = 36/308 (11%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKA---------RDKNTNQIVAIKKIKLGHRSEAKDG 54 ++K + + +GEG F V+K T ++A+KK+ Sbjct: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ----- 113 Query: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNS---LVLT 110 +R L EI L +LSHPN++ L+ + LV++FM + LE + L Sbjct: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 Query: 111 PSHIKAYMLMTLQGLEYLHQH--WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 L +GL +LH +++RD+K +N+LLD + KL+DFGLA+ + + Sbjct: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 Query: 169 Y--THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIF 226 Y T + T Y APE + + D+++ G +L E+L L + + + Sbjct: 234 YVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV- 291 Query: 227 ETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 W + + F P +R T Sbjct: 292 ---------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 Query: 287 TQ---ALK 291 Q AL+ Sbjct: 343 DQVVRALQ 350 >5HLW-A nrPDB Length = 299 Score = 191 bits (485), Expect = 5e-49, Method: Composition-based stats. Identities = 57/234 (24%), Positives = 97/234 (41%), Gaps = 15/234 (6%) Query: 16 DFLGEGQFATVYKAR---DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + +G G F VY + A+K + G L E ++++ SHP Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI----GEVSQFLTEGIIMKDFSHP 81 Query: 73 NIIGLLDAFGH-KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 N++ LL + + +V +M+ DL I++ + T + + L +G++YL Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS 141 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN----RAYTHQVVTRWYRAPELLFG 186 +HRDL N +LDE +K+ADFGLA+ T + + A E L Sbjct: 142 KKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ- 200 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 + + D+W+ G +L EL+ P P + D + + E PD Sbjct: 201 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD 254 >6CTH-A nrPDB Length = 309 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 55/206 (26%), Positives = 95/206 (46%), Gaps = 11/206 (5%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 + + LGEG F +VY+ ++++ +A+KK+ + K+ E+K++ Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYA-----SEVKIISR 68 Query: 69 LSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 L H N++ L+ + + LV++FM L+ I +LT + L Y Sbjct: 69 LRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLY 128 Query: 128 LHQ---HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP-NRAYTHQVVTRWYRAPEL 183 LH+ H +LHRD+K +N++LD + KL DFGLA+ T T Y APE Sbjct: 129 LHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPEC 188 Query: 184 LFGARMYGVGVDMWAVGCILAELLLR 209 L + D+++ G + E+ Sbjct: 189 LSSGKA-SKESDVYSFGVVALEIASG 213 >1U54-B nrPDB Length = 291 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 101/281 (35%), Gaps = 22/281 (7%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQI---VAIKKIKLGHRSEAKDGINRTALREIKLL 66 K L+ LG+G F V + + VA+K +K S+ + +RE+ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD--DFIREVNAM 75 Query: 67 QELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 L H N+I L + +V + L ++ + + Y + +G+ Sbjct: 76 HSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 134 Query: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPE 182 YL +HRDL NLLL ++K+ DFGL ++ + Y H+ V + APE Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 194 Query: 183 LLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRI-FETLGTPTEEQWPDM 240 L R + D W G L E+ G + L +I E P E P Sbjct: 195 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPC 281 V + + P L D L P Sbjct: 254 I---YNVMVQCWAHKPEDR---PTFVALRDF---LLEAQPT 285 >1U59-A nrPDB Length = 287 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 52/229 (22%), Positives = 98/229 (42%), Gaps = 13/229 (5%) Query: 17 FLGEGQFATVYKARDKNTNQI--VAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 LG G F +V + + + VAIK +K G + +RE +++ +L +P I Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT----EKADTEEMMREAQIMHQLDNPYI 72 Query: 75 IGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 + L+ ++ + LV + L + + S++ + G++YL + Sbjct: 73 VRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 131 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMY 190 +HRDL N+LL K++DFGL+K+ G+ + YT + +W + APE + R + Sbjct: 132 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF 190 Query: 191 GVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 D+W+ G + E L + + I + + P Sbjct: 191 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 239 >1AD5-A nrPDB Length = 438 Score = 190 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 110/265 (41%), Gaps = 32/265 (12%) Query: 13 EKLDFLGEGQFATVYKA-RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + LG GQF V+ A +K+T VA+K +K G S L E +++ L H Sbjct: 185 KLEKKLGAGQFGEVWMATYNKHTK--VAVKTMKPGSMS------VEAFLAEANVMKTLQH 236 Query: 72 PNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLH 129 ++ L K I ++ +FM + L +K D + + +G+ ++ Sbjct: 237 DKLVKLHAVV-TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFG 186 Q +HRDL+ N+L+ + V K+ADFGLA+ V ++ + APE + Sbjct: 296 QRNYIHRDLRAANILVSASLVCKIADFGLAR------------VGAKFPIKWTAPEAI-N 342 Query: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPD 245 + + D+W+ G +L E++ PG S+ + + + P E P+ Sbjct: 343 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL---Y 399 Query: 246 YVTFKSFPGIPLHHIFSAAGDDLLD 270 + + + P +LD Sbjct: 400 NIMMRCWKNRPEERPTFEYIQSVLD 424 >4YFF-A nrPDB Length = 311 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 63/273 (23%), Positives = 111/273 (40%), Gaps = 16/273 (5%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 E + +G G F VYK R + N+IVAIK+ + D RE+ +L +L Sbjct: 42 SEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVD--MFCREVSILCQL 97 Query: 70 SHPNIIGLLDAFG-HKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 +HP +I + A S ++V ++ L ++ + +L + +G+EY Sbjct: 98 NHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEY 157 Query: 128 LHQ--HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR-AYTHQVVTRWYRAPELL 184 LH I+HRDL +N+LL E+G +ADFG ++ S + T Q + APE+ Sbjct: 158 LHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVF 217 Query: 185 FGARMYGVGVDMWAVGCILAELLLR-VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSL 243 Y + D+++ L E+L +PF + + P P S Sbjct: 218 TQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISS 277 Query: 244 PDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 + + P +++ ++ Sbjct: 278 LLIRGWNACPE------GRPEFSEVVMKLEECL 304 >4X7Q-B nrPDB Length = 312 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 108/309 (34%), Gaps = 45/309 (14%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR-TALR 61 D ++ Y LG+G F TV+ VAIK I + T Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 83 Query: 62 EIKLLQELS----HPNIIGLLDAFGHKSNISLVFD--FMETDLEVIIKDNSLVLTPSHIK 115 E+ LL ++ HP +I LLD F + LV + DL I + L + Sbjct: 84 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG-PLGEGPSR 142 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVV 174 + + +++ H ++HRD+K N+L+D G KL DFG + YT Sbjct: 143 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH--DEPYTDFDG 200 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 TR Y PE + + + + +W++G +L +++ D + I E Sbjct: 201 TRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE------ILEAELHFPA 254 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 PD C+ LI+ P +R + + L + Sbjct: 255 HVSPDCCA----------------------------LIRRCLAPKPSSRPSLEEILLDPW 286 Query: 295 FSNRPGPTP 303 P Sbjct: 287 MQTPAEDVP 295 >5GRN-A nrPDB Length = 356 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 109/309 (35%), Gaps = 70/309 (22%) Query: 14 KLDFLGEGQFATVYKARDKNTNQ-----IVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 LG G F V + ++ VA+K +K RS K + + E+K++ Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK----QALMSELKIMTH 105 Query: 69 LS-HPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNS-------------------- 106 L H NI+ LL A I ++ ++ DL + N Sbjct: 106 LGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLL 165 Query: 107 -----LVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKS 161 LT + ++ +G+E+L +HRDL N+LL + ++K+ DFGLA+ Sbjct: 166 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD 225 Query: 162 FGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLL--RVPFLPGD 216 + + + +W APE +F +Y D+W+ G +L E+ P+ Sbjct: 226 IMHDSNYVSKGSTFLPVKW-MAPESIFD-NLYTTLSDVWSYGILLWEIFSLGGTPYPGMM 283 Query: 217 SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 D +I + A ++ +++ + Sbjct: 284 VDSTFYNKIKSGYRMAKPDH---------------------------ATSEVYEIMVKCW 316 Query: 277 LFNPCARIT 285 P R + Sbjct: 317 NSEPEKRPS 325 >3PP0-A nrPDB Length = 338 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 107/286 (37%), Gaps = 27/286 (9%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQ----IVAIKKIKLGHRSEAKDGINRTALREI 63 + K+ LG G F TVYK + VAIK ++ +A N+ L E Sbjct: 15 KETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKA----NKEILDEA 70 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + P + LL + + LV M L +++N L + + + Sbjct: 71 YVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIA 129 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYR 179 +G+ YL ++HRDL N+L+ +K+ DFGLA+ Y +V +W Sbjct: 130 KGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKW-M 188 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 A E + R + D+W+ G + EL+ G + + + P P Sbjct: 189 ALESIL-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQ----P 243 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGL--FLFNPCA 282 +C++ Y+ I S +L+ +P Sbjct: 244 PICTIDVYMIMVKCWMID-----SECRPRFRELVSEFSRMARDPQR 284 >3LZB-A nrPDB Length = 327 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 117/287 (40%), Gaps = 29/287 (10%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIV----AIKKIKLGHRSEAKDGINRTALREI 63 + ++K+ LG G F TVYK + V AIK+++ +A N+ L E Sbjct: 13 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA----NKEILDEA 68 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + +P++ LL + + L+ M L ++++ + ++ + + Sbjct: 69 YVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 127 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYR 179 +G+ YL ++HRDL N+L+ +K+ DFGLAK G+ + Y +V +W Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-M 186 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 A E + R+Y D+W+ G + EL+ G + I L P Sbjct: 187 ALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE----ISSILEKGERLPQP 241 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLI---QGLFLFNPCA 282 +C++ Y+ + I +LI + +P Sbjct: 242 PICTIDVYMIMRKCWMIDADSR-----PKFRELIIEFSKM-ARDPQR 282 >2OZO-A nrPDB Length = 613 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 51/229 (22%), Positives = 98/229 (42%), Gaps = 13/229 (5%) Query: 17 FLGEGQFATVYKARDKNTNQI--VAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 LG G F +V + + + VAIK +K G + +RE +++ +L +P I Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT----EKADTEEMMREAQIMHQLDNPYI 398 Query: 75 IGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 + L+ ++ + LV + L + + S++ + G++YL + Sbjct: 399 VRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 Query: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMY 190 +HR+L N+LL K++DFGL+K+ G+ + YT + +W + APE + R + Sbjct: 458 VHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF 516 Query: 191 GVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 D+W+ G + E L + + I + + P Sbjct: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 >5GNK-A nrPDB Length = 297 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 116/287 (40%), Gaps = 29/287 (10%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIV----AIKKIKLGHRSEAKDGINRTALREI 63 + ++K+ LG G F TVYK + V AIK+++ +A N+ L E Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA----NKEILDEA 72 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTL 122 ++ + +P++ LL + + L+ M L ++++ + ++ + + Sbjct: 73 YVMASVDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA 131 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYR 179 +G+ YL ++HRDL N+L+ +K+ DFGLAK G+ + Y +V +W Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW-M 190 Query: 180 APELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 A E + R+Y D+W+ G + EL+ G + I L P Sbjct: 191 ALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE----ISSILEKGERLPQP 245 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLI---QGLFLFNPCA 282 +C++ Y+ I +LI + +P Sbjct: 246 PICTIDVYMIMVKCWMIDADSR-----PKFRELIIEFSKM-ARDPQR 286 >3PLS-A nrPDB Length = 298 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 110/281 (39%), Gaps = 44/281 (15%) Query: 16 DFLGEGQFATVYKARDKN---TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 +G+G F VY + AIK + + + LRE L++ L+HP Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEA----FLREGLLMRGLNHP 82 Query: 73 NIIGLLDAFGHKSNI-SLVFDFM-ETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 N++ L+ + ++ +M DL I+ T + ++ L +G+EYL + Sbjct: 83 NVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAE 142 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLA-----KSFGSPNRAYTHQVVTRWYRAPELLF 185 +HRDL N +LDE+ +K+ADFGLA + + S + ++ +W A E L Sbjct: 143 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW-TALESLQ 201 Query: 186 GARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 R + D+W+ G +L ELL P D + + P E PD Sbjct: 202 TYR-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPD----- 255 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 L ++Q + +P R T Sbjct: 256 ----------------------SLYQVMQQCWEADPAVRPT 274 >3MDY-A nrPDB Length = 337 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 124/315 (39%), Gaps = 52/315 (16%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ AK+ + + +G+G++ V+ + + + VA+K + RE ++ Sbjct: 33 RTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTE--------EASWFRETEI 82 Query: 66 LQE--LSHPNIIGLLDA----FGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYM 118 Q + H NI+G + A G + + L+ D+ E L +K L + Sbjct: 83 YQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST--TLDAKSMLKLA 140 Query: 119 LMTLQGLEYLH--------QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY- 169 ++ GL +LH + I HRDLK N+L+ +NG +AD GLA F S Sbjct: 141 YSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVD 200 Query: 170 ---THQVVTRWYRAPELLFGA------RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLD 220 +V T+ Y PE+L + + Y + DM++ G IL E+ R Sbjct: 201 IPPNTRVGTKRYMPPEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRC---------- 249 Query: 221 QLTRIFETLGTPTEEQWPDMCSLPDYVTF----KSFPGIPLHHIFSAAGDDLLDLIQGLF 276 I E P + P S D K P P + L+ + Sbjct: 250 VSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECW 309 Query: 277 LFNPCARITATQALK 291 NP +R+TA + K Sbjct: 310 AHNPASRLTALRVKK 324 >3QUP-A nrPDB Length = 323 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 115/301 (38%), Gaps = 51/301 (16%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTN---QIVAIKKIKLGHRSEAKDGINRTAL 60 DV +++ LG+G+F +V +A+ K + VA+K +K + + L Sbjct: 17 DVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD---IEEFL 73 Query: 61 REIKLLQELSHPNIIGLLDAFGH---KSNI---SLVFDFME-TDLEVIIK-----DNSLV 108 RE ++E HP++ L+ K + ++ FM+ DL + +N Sbjct: 74 REAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFN 133 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 L + +M+ G+EYL +HRDL N +L E+ + +ADFGL++ S + Sbjct: 134 LPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGD-Y 192 Query: 169 YTHQVVTRW---YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTR 224 Y ++ + A E L +Y V D+WA G + E++ G + + Sbjct: 193 YRQGCASKLPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNY 251 Query: 225 IFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + +++ DL+ + +P R Sbjct: 252 LIGGNRLKQP---------------------------PECMEEVYDLMYQCWSADPKQRP 284 Query: 285 T 285 + Sbjct: 285 S 285 >2X7G-A nrPDB Length = 389 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 84/369 (22%), Positives = 132/369 (35%), Gaps = 91/369 (24%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 RY + LG G F+TV+ D + VA+K +K + TAL EIKLL+ + Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK------SAQHYTETALDEIKLLKCV 84 Query: 70 S-----HPN---IIGLLDAFGHKS----NISLVFDFMETDLEV-IIKDNSLVLTPSHIKA 116 PN ++ L+D F ++ +VF+ + L IIK N L +K+ Sbjct: 85 RESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKS 144 Query: 117 YMLMTLQGLEYLHQH-WILHRDLKPNNLL------------------------------- 144 + LQGL+YLH I+H D+KP N+L Sbjct: 145 IIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAV 204 Query: 145 ------------LDENG----VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188 LD +K+AD G A ++ +T + TR YR+ E+L GA Sbjct: 205 STAPAADLLVNPLDPRNADKIRVKIADLGNACWV---HKHFTEDIQTRQYRSIEVLIGA- 260 Query: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDS------DLDQLTRIFETLGTPTEEQWPDMCS 242 Y D+W+ C+ EL S D D + I E LG+ Sbjct: 261 GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKY 320 Query: 243 LPDYVTFKS-----FPGIPLHHIF---------SAAGDDLLDLIQGLFLFNPCARITATQ 288 ++ + P D + + P R +A + Sbjct: 321 SREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGE 380 Query: 289 ALKMKYFSN 297 L+ + ++ Sbjct: 381 CLRHPWLNS 389 >4TPT-A nrPDB Length = 303 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 46/212 (21%), Positives = 92/212 (43%), Gaps = 26/212 (12%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + LG+G F K K T +++ +K++ + +T L E+K+++ L HPN++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKEL-----IRCDEETQKTFLTEVKVMRSLDHPNVL 60 Query: 76 GLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 + ++L+ +++E + + G+ YLH I+H Sbjct: 61 KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIH 120 Query: 136 RDLKPNNLLLDENGVLKLADFGLAKSF--------------------GSPNRAYTHQVVT 175 RDL +N L+ + + +ADFGL++ + + V Sbjct: 121 RDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGN 180 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 ++ APE+L G + Y VD+++ G +L E++ Sbjct: 181 PYWMAPEMLNG-KSYDETVDIFSFGIVLCEII 211 >2JD5-A nrPDB Length = 373 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 85/336 (25%), Positives = 143/336 (42%), Gaps = 53/336 (15%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 RY + LG G F+TV+ A+D N VA+K ++ A EIKLLQ ++ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKV------YTEAAEDEIKLLQRVN 73 Query: 71 HP-----------NIIGLLDAFGHKS----NISLVFDFMETDLEVIIKDN-SLVLTPSHI 114 +I+ LLD F HK ++ +VF+ + +L +IK + ++ Sbjct: 74 DADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYV 133 Query: 115 KAYMLMTLQGLEYLHQH-WILHRDLKPNNLLLD-----ENG-VLKLADFGLAKSFGSPNR 167 K L GL+Y+H+ I+H D+KP N+L++ EN +K+AD G A + + Sbjct: 134 KQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY---DE 190 Query: 168 AYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDS------DLDQ 221 YT+ + TR YR+PE+L GA +G G D+W+ C++ EL+ D D D Sbjct: 191 HYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDH 249 Query: 222 LTRIFETLGT-PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS-------------AAGDD 267 + +I E LG P+ + + + I + + Sbjct: 250 IAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKE 309 Query: 268 LLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTP 303 + D + + +P R A + + + G Sbjct: 310 ISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEE 345 >4WUA-A nrPDB Length = 401 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 87/371 (23%), Positives = 138/371 (37%), Gaps = 93/371 (25%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 RY + LG G F+TV+ + D + VA+K +K + + TAL EI+LL+ + Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK------SAEHYTETALDEIRLLKSV 94 Query: 70 SH--PN------IIGLLDAFG----HKSNISLVFDFMETDLEV-IIKDNSLVLTPSHIKA 116 + PN ++ LLD F + ++I +VF+ + L IIK N L +K Sbjct: 95 RNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKK 154 Query: 117 YMLMTLQGLEYLHQH-WILHRDLKPNNLLLD----------------------------- 146 + LQGL+YLH I+H D+KP N+LL Sbjct: 155 IIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAV 214 Query: 147 --------------------ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 E +K+AD G A ++ +T + TR YR+ E+L G Sbjct: 215 STAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWV---HKHFTEDIQTRQYRSLEVLIG 271 Query: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDS------DLDQLTRIFETLGTPTEEQWPDM 240 + Y D+W+ C+ EL S D D + I E LG + Sbjct: 272 S-GYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG 330 Query: 241 CSLPDYVTFKS-----FPGIPL---------HHIFSAAGDDLLDLIQGLFLFNPCARITA 286 ++ T K P + D + + P R TA Sbjct: 331 KYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATA 390 Query: 287 TQALKMKYFSN 297 + L+ + ++ Sbjct: 391 AECLRHPWLNS 401 >6J5U-C nrPDB Length = 426 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 130/302 (43%), Gaps = 31/302 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYK---------ARDKNTNQIVAIKKIKLGHRSEAKDG 54 ++K+ K + + + LGEG F V+K A + +VA+K++K Sbjct: 78 ELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQ----- 132 Query: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVII-KDNSLVLTPS 112 ++ L E+ L +LSHPN++ L+ N LV++FM LE + + + LT + Sbjct: 133 GHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWA 192 Query: 113 HIKAYMLMTLQGLEYLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY- 169 + +GL +LH+ +++RD K N+LLD + KL+DFGLAK+ + + + Sbjct: 193 IRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHV 252 Query: 170 -THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 T + T Y APE + R+ D+++ G +L EL+ + + ++ + + Sbjct: 253 STKVIGTHGYAAPEYVATGRL-TAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWA 311 Query: 229 LGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQ 288 TP + + D +P +L + R ++ Sbjct: 312 --TPYLGDKRKLFRIMDTKLGGQYPQK--------GAFTAANLALQCLNPDAKLRPKMSE 361 Query: 289 AL 290 L Sbjct: 362 VL 363 >2PMN-X nrPDB Length = 348 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 66/315 (20%), Positives = 127/315 (40%), Gaps = 44/315 (13%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR------------ 57 Y + L +G+F + N+ A+KK + + +D Sbjct: 31 NDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYD 88 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD--------LEVIIKDNSLVL 109 E++++ ++ + + + + +++++ME D V+ K+ + + Sbjct: 89 DFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFI 148 Query: 110 TPSHIKAYMLMTLQGLEYLH-QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 IK + L Y+H + I HRD+KP+N+L+D+NG +KL+DFG ++ ++ Sbjct: 149 PIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMV--DKK 206 Query: 169 YTHQVVTRWYRAPELLFGARMY-GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFE 227 T + PE Y G VD+W++G L + V S L +F Sbjct: 207 IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF---SLKISLVELFN 263 Query: 228 TLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLL-----DLIQGLFLFNPCA 282 + T E Y ++ PL + S ++ L D ++ NP Sbjct: 264 NIRTKNIE----------YPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAE 313 Query: 283 RITATQALKMKYFSN 297 RIT+ ALK ++ ++ Sbjct: 314 RITSEDALKHEWLAD 328 >1PY5-A nrPDB Length = 326 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 130/314 (41%), Gaps = 50/314 (15%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65 ++ A+ + +G+G+F V++ + + + VA+K R+ RE ++ Sbjct: 25 RTIARTIVLQESIGKGRFGEVWRGKWR--GEEVAVKIFS--------SREERSWFREAEI 74 Query: 66 LQ--ELSHPNIIGLLDAFGHKS----NISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYM 118 Q L H NI+G + A + + LV D+ E L + N +T + Sbjct: 75 YQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL--NRYTVTVEGMIKLA 132 Query: 119 LMTLQGLEYLH--------QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSP----N 166 L T GL +LH + I HRDLK N+L+ +NG +AD GLA S + Sbjct: 133 LSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTID 192 Query: 167 RAYTHQVVTRWYRAPELLFGA---RMYG--VGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 A H+V T+ Y APE+L + + + D++A+G + E+ R Sbjct: 193 IAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC----------S 242 Query: 222 LTRIFETLGTPTEEQWPDMCSLPD----YVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFL 277 + I E P + P S+ + K P IP A + +++ + Sbjct: 243 IGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWY 302 Query: 278 FNPCARITATQALK 291 N AR+TA + K Sbjct: 303 ANGAARLTALRIKK 316 >2A1A-B nrPDB Length = 284 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 116/299 (38%), Gaps = 61/299 (20%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +++++ +G G F V+KA+ + + IK++K N A RE+K L +L Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYN---------NEKAEREVKALAKLD 62 Query: 71 HPNIIGL---LDAFGHKSN-------------ISLVFDFMETD--LEVIIKDNSLVLTPS 112 H NI+ D F + + + +F + + I K L Sbjct: 63 HVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKV 122 Query: 113 HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQ 172 +G++Y+H +++RDLKP+N+ L + +K+ DFGL S + + + Sbjct: 123 LALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK 182 Query: 173 VVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 T Y +PE + ++ YG VD++A+G ILAELL Sbjct: 183 -GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVC---------------------- 218 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 + T K F + I L+Q L P R ++ L+ Sbjct: 219 ----------DTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >3LLT-A nrPDB Length = 360 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 128/333 (38%), Gaps = 57/333 (17%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 + + +G+G F V + + + A+K ++ + I L++I+ + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINN- 95 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVII-KDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 NI+ F + ++ L+F+ + L II ++N IK Y + L+ L YL + Sbjct: 96 NNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRK 155 Query: 131 HWILHRDLKPNNLLLDENGV-------------------------LKLADFGLAKSFGSP 165 + H DLKP N+LLD+ +KL DFG A Sbjct: 156 MSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF---K 212 Query: 166 NRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 + + + TR YRAPE++ + V DMW+ GC+LAEL ++ L Sbjct: 213 SDYHGSIINTRQYRAPEVILNL-GWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAM- 270 Query: 226 FETLGTPTEEQ----------------------WPDMCSLPDYVTFKSFPGIPLHHIFSA 263 E++ P + WP+ S + + +PL+ I Sbjct: 271 MESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKH-VKKCLPLYKIIK- 328 Query: 264 AGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 + D + + +P R + + LK K+ Sbjct: 329 -HELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4NEU-A nrPDB Length = 333 Score = 183 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 58/295 (19%), Positives = 107/295 (36%), Gaps = 41/295 (13%) Query: 5 VKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 +K ++ + + L G F V + + +K ++ N L E K Sbjct: 19 IKMKSSDFLESAELDSGGFGKVSLCFHRTQGLM----IMKTVYKGPNCIEHNEALLEEAK 74 Query: 65 LLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 ++ L H ++ LL + SLV ++ME + + + S +L ++G Sbjct: 75 MMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEG 134 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAK-------------SFGSPNRAYTH 171 + YLH ++H+DLKP N+L+D + +K+AD GLA + Sbjct: 135 MCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKK 194 Query: 172 QVVTRWYRAPELLFGAR-MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 T +Y APE L D+++ +L + QL + Sbjct: 195 NGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIK--- 251 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 PD+ + +Y +++ L++ + NP AR T Sbjct: 252 ---SGNRPDVDDITEY-----------------CPREIISLMKLCWEANPEARPT 286 >5U6C-A nrPDB Length = 315 Score = 183 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 114/289 (39%), Gaps = 48/289 (16%) Query: 14 KLDFLGEGQFATVYKA---RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 LGEG+F +V + ++ T+ VA+K +KL + S+ + L E +++ S Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQRE---IEEFLSEAACMKDFS 96 Query: 71 HPNIIGLLDAFGHK-----SNISLVFDFME-TDLEVIIKDNSLVLTPSHI-----KAYML 119 HPN++ LL ++ FM+ DL + + L P HI +M+ Sbjct: 97 HPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV 156 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV--TRW 177 G+EYL LHRDL N +L ++ + +ADFGL+K S + ++ Sbjct: 157 DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK 216 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 + A E L R+Y D+WA G + E+ + PG + + + E Sbjct: 217 WIAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPED 275 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 D+L +++ + +P R T Sbjct: 276 ---------------------------CLDELYEIMYSCWRTDPLDRPT 297 >4LRM-A nrPDB Length = 334 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 116/290 (40%), Gaps = 32/290 (11%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIV----AIKKIKLGHRSEAKDGINRTALREI 63 + ++K+ LG G F TVYK + V AIK+++ +A N+ L E Sbjct: 17 KETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA----NKEILDEA 72 Query: 64 KLLQELSHP---NIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYML 119 ++ + +P ++ LL + + L+ M L ++++ + ++ + + Sbjct: 73 YVMASVDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV 131 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTR 176 +G+ YL ++HRDL N+L+ +K+ DFGLAK G+ + Y +V + Sbjct: 132 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIK 191 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEE 235 W A E + R+Y D+W+ G + EL+ G + I L Sbjct: 192 W-MALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASE----ISSILEKGERL 245 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLI---QGLFLFNPCA 282 P +C++ Y+ I +LI + +P Sbjct: 246 PQPPICTIDVYMIMVKCWMIDADSR-----PKFRELIIEFSKM-ARDPQR 289 >3UIU-A nrPDB Length = 306 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 116/312 (37%), Gaps = 74/312 (23%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 +++++ +G G F V+KA+ + + I+++K N A RE+K L +L Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYN---------NEKAEREVKALAKLD 63 Query: 71 HPNIIGL---LDAFGHKSN--------------------------ISLVFDFMETD--LE 99 H NI+ D F + + + +F + + Sbjct: 64 HVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQ 123 Query: 100 VIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLA 159 I K L +G++Y+H ++HRDLKP+N+ L + +K+ DFGL Sbjct: 124 WIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLV 183 Query: 160 KSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDL 219 S + + + T Y +PE + ++ YG VD++A+G ILAELL Sbjct: 184 TSLKNDGKRTRSK-GTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVC--------- 232 Query: 220 DQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN 279 + T K F + I L+Q L Sbjct: 233 -----------------------DTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKK 269 Query: 280 PCARITATQALK 291 P R ++ L+ Sbjct: 270 PEDRPNTSEILR 281 >4C59-A nrPDB Length = 340 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 123/307 (40%), Gaps = 64/307 (20%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 R L EG FA VY+A+D + + A+K++ ++ NR ++E+ +++LS Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRL-----LSNEEEKNRAIIQEVCFMKKLS 82 Query: 71 -HPNIIGLL--------DAFGHKSNISLVFDFMETDLEVIIK--DNSLVLTPSHIKAYML 119 HPNI+ ++ ++ L+ + + L +K ++ L+ + Sbjct: 83 GHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFY 142 Query: 120 MTLQGLEYLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAKSFGS-PNRAYT------ 170 T + ++++H+ I+HRDLK NLLL G +KL DFG A + P+ +++ Sbjct: 143 QTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRAL 202 Query: 171 -----HQVVTRWYRAPELLFGARMY--GVGVDMWAVGCILAELLLRV-PFLPGDSDLDQL 222 + T YR PE++ + G D+WA+GCIL L R PF G Sbjct: 203 VEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAK----- 257 Query: 223 TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCA 282 RI + LI+ + NP Sbjct: 258 LRIVNGKYSIPPHDTQYTV--------------------------FHSLIRAMLQVNPEE 291 Query: 283 RITATQA 289 R++ + Sbjct: 292 RLSIAEV 298 >4IDT-A nrPDB Length = 356 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 106/315 (33%), Gaps = 59/315 (18%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 LG G F V++ DK T A+KK++L E+ L+ P I+ L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE----------ELMACAGLTSPRIVPL 131 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRD 137 A +++ + +E + L Y+ L+GLEYLH ILH D Sbjct: 132 YGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 138 LKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTHQV-----VTRWYRAPELLFGARMYG 191 +K +N+LL +G L DFG A T + APE++ G R Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG-RSCD 250 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 VD+W+ C++ +L W P + S Sbjct: 251 AKVDVWSSCCMMLHMLNGC------------------------HPWTQFFRGPLCLKIAS 286 Query: 252 FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA-------------LKMKYFSNR 298 P P+ I + IQ P R++A + LK + Sbjct: 287 EP-PPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPW---- 341 Query: 299 PGPTPGCQLPRPNCP 313 G + P PN Sbjct: 342 RGEYKEPRHPPPNQA 356 >6B2Q-A nrPDB Length = 317 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 9/216 (4%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + + RY + G V++A D + VA+K +K S+ + E + Sbjct: 29 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE--FIERFRAEARTT 86 Query: 67 QELSHPNIIGLLDA-----FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+HP I + D G LV + + + + + L+ H + T Sbjct: 87 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 146 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV-VTRWYRA 180 + L+ H ++HRD+KP N+L+ G +K+ DFG+AK+ + T V T Y A Sbjct: 147 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 206 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 PE G D++++G + E + GD Sbjct: 207 PEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 9/216 (4%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + + RY + G V++A D + VA+K +K S+ + E + Sbjct: 9 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE--FIERFRAEARTT 66 Query: 67 QELSHPNIIGLLDA-----FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+HP I + D G LV + + + + + L+ H + T Sbjct: 67 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 126 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV-VTRWYRA 180 + L+ H ++HRD+KP N+L+ G +K+ DFG+AK+ + T V T Y A Sbjct: 127 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 186 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 PE G D++++G + E + GD Sbjct: 187 PEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 221 >4OW8-A nrPDB Length = 283 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 9/216 (4%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + + RY + G V++A D + VA+K +K S+ + E + Sbjct: 8 TLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPE--FIERFRAEARTT 65 Query: 67 QELSHPNIIGLLDA-----FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L+HP I + D G LV + + + + + L+ H + T Sbjct: 66 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQT 125 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV-VTRWYRA 180 + L+ H ++HRD+KP N+L+ G +K+ DFG+AK+ + T V T Y A Sbjct: 126 GRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIA 185 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 PE G D++++G + E + GD Sbjct: 186 PEQALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGD 220 >3SOC-A nrPDB Length = 322 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 79/295 (26%), Positives = 126/295 (42%), Gaps = 36/295 (12%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + L+ G+F V+KA+ N+ VA+K + + ++ E+ L + H Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEY------EVYSLPGMKHE 78 Query: 73 NIIGLLDAFGHKS----NISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 NI+ + A + ++ L+ F E L +K N V++ + + +GL Y Sbjct: 79 NILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN--VVSWNELCHIAETMARGLAY 136 Query: 128 LHQ----------HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVT 175 LH+ I HRD+K N+LL N +ADFGLA F + A QV T Sbjct: 137 LHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGT 196 Query: 176 RWYRAPELLFGARMYGV----GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT 231 R Y APE+L GA + +DM+A+G +L EL R G D L E Sbjct: 197 RRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQH 256 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 P+ E ++ V K P + + A L + I+ + + AR++A Sbjct: 257 PSLEDMQEVV-----VHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >3AOX-A nrPDB Length = 344 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 101/308 (32%), Gaps = 51/308 (16%) Query: 3 LDVKSRAKR-YEKLDFLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGIN 56 D+K ++ + LG G F VY+ + + + VA+K + + Sbjct: 39 SDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP----EVCSEQDE 94 Query: 57 RTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPS--- 112 L E ++ + +H NI+ + ++ + M DL+ +++ + Sbjct: 95 LDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSL 154 Query: 113 ---HIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG---VLKLADFGLAKSFGSPN 166 + G +YL ++ +HRD+ N LL G V K+ DFG+A+ + Sbjct: 155 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 214 Query: 167 RAYTHQVVTRW--YRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLT 223 + PE ++ D W+ G +L E+ P S+ + L Sbjct: 215 YYRKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVL- 272 Query: 224 RIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCAR 283 E + + P C P Y + + P R Sbjct: 273 ---EFVTSGGRMDPPKNCPGPVYRI-----------------------MTQCWQHQPEDR 306 Query: 284 ITATQALK 291 L+ Sbjct: 307 PNFAIILE 314 >2RIO-A nrPDB Length = 434 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 68/311 (21%), Positives = 121/311 (38%), Gaps = 63/311 (20%) Query: 16 DFLGEGQFATV-YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPN 73 LG G TV ++ + + VA+K++ + AL EIKLL E HPN Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRMLI--------DFCDIALMEIKLLTESDDHPN 70 Query: 74 IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV------LTPSHIKAYMLMTLQGLEY 127 +I + + + + +L+ +++ ++ + + + G+ + Sbjct: 71 VIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAH 130 Query: 128 LHQHWILHRDLKPNNLLLD-------------ENGVLKLADFGLAKSFGSPNRAYTHQV- 173 LH I+HRDLKP N+L+ EN + ++DFGL K S ++ + Sbjct: 131 LHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLN 190 Query: 174 ---VTRWYRAPELLFG------ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTR 224 T +RAPELL R +D++++GC+ +L + GD + + Sbjct: 191 NPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE-SN 249 Query: 225 IFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 I + + E + SL + DLI + +P R Sbjct: 250 IIRGIFSLDEMKCLHDRSL---------------------IAEATDLISQMIDHDPLKRP 288 Query: 285 TATQALKMKYF 295 TA + L+ F Sbjct: 289 TAMKVLRHPLF 299 >5WNO-A nrPDB Length = 330 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 103/282 (36%), Gaps = 45/282 (15%) Query: 13 EKLDFLGEGQFATVYKA-----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 + LG G F TV+ R KN VAIK + + L E + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDE------MLEEATNMF 78 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 L H N++ ++ H + +V + +L+ +K + L Y G++ Sbjct: 79 RLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQ 138 Query: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT---HQVVTRWYRAPEL 183 YL + ++HRDL N+L+ + +++ DFGL+K + T +V +W A E Sbjct: 139 YLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKW-LAIE- 196 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 +F Y D+WA G E++ G S S Sbjct: 197 IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMS----------------------TDS 234 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + +++ + P DL + ++ +P +R Sbjct: 235 IHNFLKDGNRLSQP-----PNCSQDLYQELLRCWMADPKSRP 271 >5WNL-A nrPDB Length = 342 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 68/335 (20%), Positives = 124/335 (37%), Gaps = 35/335 (10%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67 A + + +G G F VYK R + +AIK H + + L E K ++ Sbjct: 18 DAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRE---RMELLEEAKKME 74 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 I+ + + LV ++ME LE ++ S L + T G+ Sbjct: 75 MAKFRYILPVYGICQE--PVGLVMEYMETGSLEKLL--ASEPLPWDLRFRIVHETAVGMN 130 Query: 127 YLH--QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG---SPNRAYTHQVVTRWYRAP 181 +LH +LH +LKP N+LLD + +K++DFGLAK G S + + T Y P Sbjct: 131 FLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPP 190 Query: 182 ELL-FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 E + +R++ D+++ ++ +L + + + + I + + P + Sbjct: 191 ERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKN---ILHIMMKVVKGHRPELPPI 247 Query: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL-KMKYFSNRP 299 C A L+ L+Q + +P R T + + + +P Sbjct: 248 CRPR-----------------PRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEKP 290 Query: 300 GPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEA 334 P + + + KR A Sbjct: 291 DEEVKDLAHEPGEKSSLESKSEARPESSRLKRASA 325 >4PL5-B nrPDB Length = 435 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 112/296 (37%), Gaps = 46/296 (15%) Query: 15 LDFLGEGQFAT-VYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HP 72 D LG G T VYK N+ VA+K+I S A RE++LL+E HP Sbjct: 32 KDVLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFAD--------REVQLLRESDEHP 81 Query: 73 NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 N+I + + + L+ ++ + T GL +LH Sbjct: 82 NVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLN 141 Query: 133 ILHRDLKPNNLLL---DENGVLK--LADFGLAKSFGSPNRAYTHQVV---TRWYRAPELL 184 I+HRDLKP+N+LL + +G +K ++DFGL K +++ + T + APE+L Sbjct: 142 IVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 201 Query: 185 FGARMY--GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 VD+++ GC+ ++ G S Q + Sbjct: 202 SEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGAC------------- 248 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + H +LI+ + +P R +A LK +F + Sbjct: 249 -----------NLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSL 293 >5LPZ-A nrPDB Length = 332 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 59/217 (27%), Positives = 101/217 (46%), Gaps = 16/217 (7%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D+ + +G G F VYKA K+ VAIKK+ +R + E Sbjct: 10 ADLLQATNGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKL-----IHVSGQGDREFMAE 63 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVII---KDNSLVLTPSHIKAYM 118 ++ + ++ H N++ LL LV++FM+ LE ++ K + L S + Sbjct: 64 METIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIA 123 Query: 119 LMTLQGLEYLHQH---WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--THQV 173 + + +GL +LH + I+HRD+K +N+LLDEN +++DFG+A+ + + + Sbjct: 124 IGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLA 183 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV 210 T Y PE R D+++ G +L ELL Sbjct: 184 GTPGYVPPEYYQSFRC-STKGDVYSYGVVLLELLTGK 219 >6HV0-A nrPDB Length = 416 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 114/298 (38%), Gaps = 50/298 (16%) Query: 15 LDFLGEGQFAT-VYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HP 72 D LG G T VY+ N+ VA+K+I S A RE++LL+E HP Sbjct: 13 KDVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFAD--------REVQLLRESDEHP 62 Query: 73 NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 N+I + + + L+ ++ + T GL +LH Sbjct: 63 NVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLN 122 Query: 133 ILHRDLKPNNLLL---DENGVLK--LADFGLAKSFGSPNRAYTHQV---VTRWYRAPELL 184 I+HRDLKP+N+L+ + +G +K ++DFGL K +++ + T + APE+L Sbjct: 123 IVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEML 182 Query: 185 FG--ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 VD+++ GC+ ++ G S Q + Sbjct: 183 SEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAC------------- 229 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDD--LLDLIQGLFLFNPCARITATQALKMKYFSNR 298 L + +D +LI+ + +P R +A LK +F + Sbjct: 230 -------------SLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSL 274 >5E8V-A nrPDB Length = 316 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 124/302 (41%), Gaps = 43/302 (14%) Query: 13 EKLDFLGEGQFATVYKARDKNTN----QIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 E +G+G+FA VYKA+ K + VA+K + A + +I Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YEEYASWKTEKDIFSDIN---- 65 Query: 69 LSHPNIIGLLDAFGHKSNI----SLVFDF-METDLEVIIKDNSLVLTPSHIKAYMLMTLQ 123 L H NI+ L A K+ + L+ F + +L+ + + V++ ++ + Sbjct: 66 LKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH--VISWEDLRKLGSSLAR 123 Query: 124 GLEYLHQ---------HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS----PNRAYT 170 G+ +LH I+HRDLK +N+L+ + L DFGL+ + A + Sbjct: 124 GIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANS 183 Query: 171 HQVVTRWYRAPELLFGARMYG-----VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRI 225 QV T Y APE+L A D++++ +L E+ R + D + Sbjct: 184 GQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEP---- 239 Query: 226 FETLGTPTEEQWPDMCSLPDYVTFKS-FPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 G+ E P + S+ D V + P IP + + + + + +P AR+ Sbjct: 240 --PFGSKVREH-PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARL 296 Query: 285 TA 286 TA Sbjct: 297 TA 298 >5LPV-A nrPDB Length = 296 Score = 173 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 59/217 (27%), Positives = 101/217 (46%), Gaps = 16/217 (7%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D+ + +G G F VYKA K+ VAIKK+ +R + E Sbjct: 10 ADLLQATNGFHNDSLIGSGGFGDVYKAILKD-GSAVAIKKL-----IHVSGQGDREFMAE 63 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVII---KDNSLVLTPSHIKAYM 118 ++ + ++ H N++ LL LV++FM+ LE ++ K + L S + Sbjct: 64 METIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIA 123 Query: 119 LMTLQGLEYLHQH---WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY--THQV 173 + + +GL +LH + I+HRD+K +N+LLDEN +++DFG+A+ + + + Sbjct: 124 IGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLA 183 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV 210 T Y PE R D+++ G +L ELL Sbjct: 184 GTPGYVPPEYYQSFRC-STKGDVYSYGVVLLELLTGK 219 >3ZZW-A nrPDB Length = 289 Score = 173 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 107/278 (38%), Gaps = 33/278 (11%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARD-----KNTNQIVAIKKIKLGHRSEAKDGINR 57 ++ A R+ ++ LGE +F VYK Q VAIK +K +A+ + Sbjct: 4 KEISLSAVRF--MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK----DKAEGPLRE 57 Query: 58 TALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVII-------------- 102 E L L HPN++ LL +S++F + DL + Sbjct: 58 EFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDD 117 Query: 103 -KDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKS 161 + L P + G+EYL H ++H+DL N+L+ + +K++D GL + Sbjct: 118 DRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFRE 177 Query: 162 FGSPNRAY---THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL-LRVPFLPGDS 217 + + + RW APE + + + D+W+ G +L E+ + G S Sbjct: 178 VYAADYYKLLGNSLLPIRW-MAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYS 235 Query: 218 DLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGI 255 + D + I P + P + FP Sbjct: 236 NQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSR 273 >3UIM-A nrPDB Length = 326 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 57/214 (26%), Positives = 94/214 (43%), Gaps = 14/214 (6%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 +++ + + + LG G F VYK R +VA+K++K E G E+ Sbjct: 24 ELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLK----EERTQGGELQFQTEV 78 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSL---VLTPSHIKAYML 119 +++ H N++ L + LV+ +M + +++ L + L Sbjct: 79 EMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIAL 138 Query: 120 MTLQGLEYLHQH---WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV-VT 175 + +GL YLH H I+HRD+K N+LLDE + DFGLAK + T V T Sbjct: 139 GSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGT 198 Query: 176 RWYRAPELLFGARMYGVGVDMWAVGCILAELLLR 209 + APE L + D++ G +L EL+ Sbjct: 199 IGHIAPEYLSTGKS-SEKTDVFGYGVMLLELITG 231 >4F0G-A nrPDB Length = 287 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 108/286 (37%), Gaps = 40/286 (13%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINR--TALREIKLLQ 67 E +G+G F V+K R +VAIK + LG + I + RE+ ++ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 68 ELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 L+HPNI+ L + +V +F+ DL + D + + S ML G+E Sbjct: 79 NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIE 136 Query: 127 YLHQHW--ILHRDLKPNNLL---LDENGVL--KLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Y+ I+HRDL+ N+ LDEN + K+ADFGL++ + + + + Sbjct: 137 YMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNFQWM 193 Query: 180 APELL-FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE + Y D ++ IL +L D +I E P Sbjct: 194 APETIGAEEESYTEKADTYSFAMILYTILTGEGPF----DEYSYGKIKFINMIREEGLRP 249 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + L ++I+ + +P R Sbjct: 250 TIPE--------------------DCPPRLRNVIELCWSGDPKKRP 275 >2QKW-B nrPDB Length = 321 Score = 171 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 55/212 (25%), Positives = 99/212 (46%), Gaps = 13/212 (6%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 +D++ ++ +G G F VYK ++ VA+K+ R+ E Sbjct: 32 VDLEEATNNFDHKFLIGHGVFGKVYKGVLRD-GAKVALKR-----RTPESSQGIEEFETE 85 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLV---LTPSHIKAYM 118 I+ L HP+++ L+ ++ + L++ +ME L+ + + L ++ Sbjct: 86 IETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEIC 145 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQV--VTR 176 + +GL YLH I+HRD+K N+LLDEN V K+ DFG++K ++ + V T Sbjct: 146 IGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTL 205 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLL 208 Y PE R+ D+++ G +L E+L Sbjct: 206 GYIDPEYFIKGRL-TEKSDVYSFGVVLFEVLC 236 >4FL3-A nrPDB Length = 635 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 100/275 (36%), Gaps = 38/275 (13%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 LG G F TV K + + + +K+ + L E ++Q+L +P I+ Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTV-AVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 Query: 76 GLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 ++ +S + LV + E L ++ N V + I + G++YL + + Sbjct: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKN-IIELVHQVSMGMKYLEESNFV 491 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAPELLFGARMY 190 HRDL N+LL K++DFGL+K+ + Y + +WY APE + + Sbjct: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-NYYKF 549 Query: 191 GVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 D+W+ G ++ E G + + + P Sbjct: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR---------- 599 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 ++ DL+ + ++ R Sbjct: 600 -----------------EMYDLMNLCWTYDVENRP 617 >4JLC-A nrPDB Length = 657 Score = 170 bits (432), Expect = 7e-43, Method: Composition-based stats. Identities = 56/231 (24%), Positives = 101/231 (43%), Gaps = 25/231 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + A+K D +RE ++L++L+H NI+ Sbjct: 14 DILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ----MREFEVLKKLNHKNIV 69 Query: 76 GLLDAFGHKS--NISLVFDFME-TDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L + + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 70 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 129 Query: 131 HWILHRDLKPNNLL--LDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HRD+KP N++ + E+G KL DFG A+ + + T Y P++ Sbjct: 130 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 188 Query: 187 -------ARMYGVGVDMWAVGCILAELLLRV----PFLPGDSDLDQLTRIF 226 + YG VD+W+VG PF + + + +I Sbjct: 189 AVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 239 >4EUU-A nrPDB Length = 319 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 101/231 (43%), Gaps = 25/231 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNHKNIV 70 Query: 76 GLLDAFGHKS--NISLVFDFME-TDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L + + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 131 HWILHRDLKPNNLL--LDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G KL DFG A+ + + T Y P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 189 Query: 187 -------ARMYGVGVDMWAVGCILAELLLRV----PFLPGDSDLDQLTRIF 226 + YG VD+W++G PF + + + +I Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >4EUT-A nrPDB Length = 396 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 101/231 (43%), Gaps = 25/231 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 15 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNHKNIV 70 Query: 76 GLLDAFGHKS--NISLVFDFME-TDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L + + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 71 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 131 HWILHRDLKPNNLL--LDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G KL DFG A+ + + T Y P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 189 Query: 187 -------ARMYGVGVDMWAVGCILAELLLRV----PFLPGDSDLDQLTRIF 226 + YG VD+W++G PF + + + +I Sbjct: 190 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >2QLU-A nrPDB Length = 314 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 84/296 (28%), Positives = 126/296 (42%), Gaps = 37/296 (12%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 + L+ G+F V+KA+ N VA+K L +D + + REI + H Sbjct: 18 QLLEIKARGRFGCVWKAQLMND--FVAVKIFPL------QDKQSWQSEREIFSTPGMKHE 69 Query: 73 NIIGLLDAFGHKSNI----SLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 N++ + A SN+ L+ F + L +K N ++T + + +GL Y Sbjct: 70 NLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGN--IITWNELCHVAETMSRGLSY 127 Query: 128 LHQ-----------HWILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVV 174 LH+ I HRD K N+LL + LADFGLA F G P QV Sbjct: 128 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 187 Query: 175 TRWYRAPELLFGARMYGV----GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 TR Y APE+L GA + +DM+A+G +L EL+ R G D L E Sbjct: 188 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 247 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 P+ E+ ++ V K P I H + L I+ + + AR++A Sbjct: 248 HPSLEELQEVV-----VHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >5C26-A nrPDB Length = 299 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 100/275 (36%), Gaps = 38/275 (13%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 LG G F TV K + + + +K+ + L E ++Q+L +P I+ Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTV-AVKILKNEANDPALKDELLAEANVMQQLDNPYIV 91 Query: 76 GLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 ++ +S + LV + E L ++ N V + I + G++YL + + Sbjct: 92 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKN-IIELVHQVSMGMKYLEESNFV 149 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYT----HQVVTRWYRAPELLFGARMY 190 HRDL N+LL K++DFGL+K+ + Y + +WY APE + + Sbjct: 150 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-NYYKF 207 Query: 191 GVGVDMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 D+W+ G ++ E G + + + P Sbjct: 208 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR---------- 257 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 ++ DL+ + ++ R Sbjct: 258 -----------------EMYDLMNLCWTYDVENRP 275 >4G3E-A nrPDB Length = 352 Score = 166 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 17/199 (8%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 +G G F V++ +DK T A+KK++L + E+ LS P I+ L Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR----------VEELVACAGLSSPRIVPL 131 Query: 78 LDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRD 137 A +++ + +E + L Y+ L+GLEYLH ILH D Sbjct: 132 YGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGD 191 Query: 138 LKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTHQV-----VTRWYRAPELLFGARMYG 191 +K +N+LL +G L DFG A + T + APE++ G + Sbjct: 192 VKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMG-KPCD 250 Query: 192 VGVDMWAVGCILAELLLRV 210 VD+W+ C++ +L Sbjct: 251 AKVDIWSSCCMMLHMLNGC 269 >2BUJ-A nrPDB Length = 317 Score = 166 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 110/309 (35%), Gaps = 55/309 (17%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 K Y + LGEG F+ V + A+K+I + + ++ A RE + + Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREE-----AQREADMHRLF 83 Query: 70 SHPNIIGLLDAFGH----KSNISLVFDFMETDLE----VIIKDNSLVLTPSHIKAYMLMT 121 +HPNI+ L+ K L+ F + +KD LT I +L Sbjct: 84 NHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGI 143 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGL----AKSFGSPNRAYT-----HQ 172 +GLE +H HRDLKP N+LL + G L D G +A T Q Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQ 203 Query: 173 VVTRWYRAPEL--LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 T YRAPEL + + D+W++GC+L ++ + G Sbjct: 204 RCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD----------MVFQKG 253 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCAR------I 284 + S+P L L+ + +P R + Sbjct: 254 DSVALAVQNQLSIPQ---------------SPRHSSALWQLLNSMMTVDPHQRPHIPLLL 298 Query: 285 TATQALKMK 293 + +AL+ Sbjct: 299 SQLEALQPP 307 >6O8B-A nrPDB Length = 665 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 101/231 (43%), Gaps = 25/231 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 21 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNHKNIV 76 Query: 76 GLLDAFGHKS--NISLVFDFME-TDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L + + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 77 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 136 Query: 131 HWILHRDLKPNNLL--LDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G KL DFG A+ + + T Y P++ Sbjct: 137 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVELYGTEEYLHPDMYER 195 Query: 187 -------ARMYGVGVDMWAVGCILAELLLRV----PFLPGDSDLDQLTRIF 226 + YG VD+W++G PF + + + +I Sbjct: 196 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 246 >5TE0-A nrPDB Length = 347 Score = 165 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 80/347 (23%), Positives = 132/347 (38%), Gaps = 61/347 (17%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNI 74 + L EG FA V+ R + A+K++ + + + + REI+++++LS H NI Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDL-----QVCKREIQIMRDLSGHKNI 78 Query: 75 IGLLDAF------GHKSNISLVFDFMETDLEVIIKDNSLV--LTPSHIKAYMLMTLQGLE 126 +G +D+ G + ++ DF V + + L T + + T + + Sbjct: 79 VGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVA 138 Query: 127 YLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQV-------VTR 176 LHQ I+HRDLK N+LL + G L DFG A F +P + V T Sbjct: 139 RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 177 WYRAPEL--LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 YRAPE+ L+ ++ D+WA+GC+L +L G Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF----------------GESQV 242 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKY 294 ++PD S D+ LI+ + +P R Q Y Sbjct: 243 AICDGNFTIPDN---------------SRYSQDMHCLIRYMLEPDPDKRPDIYQV---SY 284 Query: 295 FSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLP 341 FS + N P+ + A K+T+ + P Sbjct: 285 FSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDP 331 >6NT9-A nrPDB Length = 742 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 55/231 (23%), Positives = 101/231 (43%), Gaps = 25/231 (10%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 D LG+G A V++ R K T + AIK D +RE ++L++L+H NI+ Sbjct: 13 DILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKLNHKNIV 68 Query: 76 GLLDAFGHKS--NISLVFDFME-TDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLHQ 130 L + + L+ +F L ++++ N+ L S + + G+ +L + Sbjct: 69 KLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 Query: 131 HWILHRDLKPNNLL--LDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186 + I+HR++KP N++ + E+G KL DFG A+ + + T Y P++ Sbjct: 129 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-EDDEQFVSLYGTEEYLHPDMYER 187 Query: 187 -------ARMYGVGVDMWAVGCILAELLLRV----PFLPGDSDLDQLTRIF 226 + YG VD+W++G PF + + + +I Sbjct: 188 AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 >3G2F-A nrPDB Length = 336 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 118/319 (36%), Gaps = 51/319 (15%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A + + L+ +G G++ VYK + VA+K +R + + Sbjct: 5 ASEPSLDLDNLKLLELIGRGRYGAVYKGS--LDERPVAVKVFSFANR--------QNFIN 54 Query: 62 EIKLLQ--ELSHPNIIGLL---DAFGHKSNI--SLVFDFM-ETDLEVIIKDNSLVLTPSH 113 E + + + H NI + + + LV ++ L + ++ Sbjct: 55 EKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS--DWVS 112 Query: 114 IKAYMLMTLQGLEYLH---------QHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-- 162 +GL YLH + I HRDL N+L+ +G ++DFGL+ Sbjct: 113 SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG 172 Query: 163 ------GSPNRAYTHQVVTRWYRAPELLFG------ARMYGVGVDMWAVGCILAELLLRV 210 G + A +V T Y APE+L G VDM+A+G I E+ +R Sbjct: 173 NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC 232 Query: 211 P-FLPGDS-DLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG-DD 267 PG+S Q+ E PT E + S K P P ++ Sbjct: 233 TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVS-----REKQRPKFPEAWKENSLAVRS 287 Query: 268 LLDLIQGLFLFNPCARITA 286 L + I+ + + AR+TA Sbjct: 288 LKETIEDCWDQDAEARLTA 306 >2Y4I-B nrPDB Length = 319 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 117/298 (39%), Gaps = 34/298 (11%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++ E + +G+G+F VY R VAI+ I + +E + + RE+ ++ Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQ---LKAFKREVMAYRQT 86 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 H N++ + A +++++ + L +++D +VL + + ++G+ YL Sbjct: 87 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL 146 Query: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGL---AKSFGSPNRAYTHQVVTRW--YRAPEL 183 H ILH+DLK N+ D NG + + DFGL + + R ++ W + APE+ Sbjct: 147 HAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEI 205 Query: 184 L--------FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEE 235 + + D++A+G I EL R I +GT + Sbjct: 206 IRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKT----QPAEAIIWQMGTGMKP 261 Query: 236 QWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 + + F L+D+++ L N R++ Sbjct: 262 NLSQIGMGKEISDILLF-CWAFEQEERPTFTKLMDMLEKLPKRN--RRLS------HP 310 >5XD6-A nrPDB Length = 305 Score = 163 bits (413), Expect = 9e-41, Method: Composition-based stats. Identities = 53/234 (22%), Positives = 95/234 (40%), Gaps = 22/234 (9%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 A +++ Y +GEG + V+ K + + AIKK+ + + + L Sbjct: 14 ADELRDITDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD------QEFLA 66 Query: 62 EIKLLQELSHPNIIGLLDAFGHKSNISLVFDFM-ETDLEVIIKDN--------SLVLTPS 112 ++ ++ L N++ LL L +++ L I+ VL+ Sbjct: 67 QVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWH 126 Query: 113 HIKAYMLMTLQGLEYLHQH---WILHRDLKPNNLLLDENGVLKLADFGLAKSFGS--PNR 167 + +GLEYLH+ ++HRD+K +N+LL ++ V K+ADF L+ Sbjct: 127 QRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARL 186 Query: 168 AYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQ 221 T + T Y APE + D+++ G +L ELL + Q Sbjct: 187 HSTRVLGTFGYHAPEYAMTGTL-STKSDVYSFGVVLLELLTGRKPVDHTLPRGQ 239 >3LMG-A nrPDB Length = 344 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 110/281 (39%), Gaps = 21/281 (7%) Query: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQ----IVAIKKIKLGHRSEAKDGINRTALREI 63 + KL LG G F TV+K + V IK I+ ++ + L Sbjct: 29 KETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHML--- 85 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTL 122 + L H +I+ LL S++ LV ++ L ++ + L P + + + Sbjct: 86 -AIGSLDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIA 143 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA--YTHQVVTRWYRA 180 +G+ YL +H ++HR+L N+LL +++ADFG+A ++ Y+ + A Sbjct: 144 KGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMA 203 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 E + Y D+W+ G + EL+ G +L + + L P Sbjct: 204 LESIH-FGKYTHQSDVWSYGVTVWELMTFGAEPYAGL----RLAEVPDLLEKGERLAQPQ 258 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNP 280 +C++ Y+ I +I + + + +P Sbjct: 259 ICTIDVYMVMVKCWMID-ENIRPTFKELANEFTR--MARDP 296 >4LQP-A nrPDB Length = 508 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 75/159 (47%), Gaps = 2/159 (1%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + + + +G+G F V + K+T +I A+K + + + A R +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAER--DVLAGS 159 Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 P ++ L +F + L+ +F+ + + + T + YM + +E +H Sbjct: 160 DSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIH 219 Query: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 + +HR +KP+N+L+D G +KL+DFGL+ F + + Sbjct: 220 KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDS 258 Score = 89.6 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 37/186 (19%), Positives = 60/186 (32%), Gaps = 44/186 (23%) Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 V T Y APE+ + YG D W++G I+ E L+ P ++ + +I Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN--- 377 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI----TA 286 + PD + + DLI+ L R+ A Sbjct: 378 ------FEQTLQFPDDIHI---------------SYEAEDLIRRLLTH-ADQRLGRHGGA 415 Query: 287 TQALKMKYFSNRPGPTPGCQLPRPNCPVET---------LKEQSN----PALAIKRKRTE 333 + +F T Q+ P P + E N PA+A K+ E Sbjct: 416 DEIKSHPFFRGVDWNTIR-QVEAPYIPKLSSITDTRFFPTDELENVPDSPAMAQAAKQRE 474 Query: 334 ALEQGG 339 + + G Sbjct: 475 QMTKQG 480 >5IKW-A nrPDB Length = 310 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 79/335 (23%), Positives = 124/335 (37%), Gaps = 73/335 (21%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-H 71 + L EG F+TV+ R A+K++ + + + REI +++ELS H Sbjct: 17 TLEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLN-----VCKREITIMKELSGH 70 Query: 72 PNIIGLLD--AFGHKSNIS---LVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQG 124 NI+G LD N+ ++ ++ + + K T + T + Sbjct: 71 KNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEA 130 Query: 125 LEYLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAK-SFGSPNRAYTHQV-------V 174 + LHQ I+HRDLK N+LL++ G L DFG A F +P + + V Sbjct: 131 VARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190 Query: 175 TRWYRAPEL--LFGARMYGVGVDMWAVGCILAEL-LLRVPFLPGDSDLDQLTRIFETLGT 231 T YRAPE+ L+G + D+WA+GC+L +L +PF G Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-----------------GE 233 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 ++PD + LI+ + +P R Q Sbjct: 234 SQVAICDGNFTIPDNSRYSRNIHC---------------LIRFMLEPDPEHRPDIFQV-- 276 Query: 292 MKYF-----------SNRPGPTPGCQLPRPNCPVE 315 YF SN + LP P E Sbjct: 277 -SYFAFKFAAADCPVSNINNSSIPSALPEPMTASE 310 >6BFN-A nrPDB Length = 342 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 56/208 (26%), Positives = 91/208 (43%), Gaps = 19/208 (9%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIG 76 +GEG F VY+A +NT + A+K++K E + ++ L E++ L HPNI+ Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWT-AVKQSFLTEVEQLSRFRHPNIVD 85 Query: 77 LLDAFGHKSNISLVFDFM-ETDLEVIIKDNSL---VLTPSHIKAYMLMTLQGLEYLH--Q 130 LV+ F+ LE + + L+ +L T + +++LH Sbjct: 86 FAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDS 145 Query: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAK---------SFGSPNRAYTHQVVTRWYRAP 181 ++H D+K +N+LLDE KL DFGLA+ S S T Y Sbjct: 146 PSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPE 205 Query: 182 ELLFGARMYGVGVDMWAVGCILAELLLR 209 E + R+ V D ++ G ++ E L Sbjct: 206 EYIKTGRL-AVDTDTFSFGVVVLETLAG 232 >4F9B-A nrPDB Length = 361 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 76/353 (21%), Positives = 127/353 (35%), Gaps = 84/353 (23%) Query: 12 YEKLDFLGEGQFATVYKARDK---NTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++ D +GEG F++VY A + + +A+K + I++ E Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------------IRIAAE 69 Query: 69 LSH-------PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLM 120 L N++G+ F ++ + ++E I+ L+ ++ YML Sbjct: 70 LQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS----LSFQEVREYMLN 125 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPN------------- 166 + L+ +HQ I+HRD+KP+N L + L DFGLA+ Sbjct: 126 LFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQ 185 Query: 167 ---------------RAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR-V 210 + + T +RAPE+L +DMW+ G I LL Sbjct: 186 ERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRY 245 Query: 211 PFLPGDSDLDQLTRIFETLGTP----------------TEEQWPDMCSLPDYVTFKSFPG 254 PF DL L +I G+ E D+ L + + Sbjct: 246 PFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSST 305 Query: 255 IPLH----------HIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 L ++ D+ DL+ L NP +RITA +AL +F + Sbjct: 306 PKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >4M66-A nrPDB Length = 325 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 108/297 (36%), Gaps = 43/297 (14%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 + +KL+F+G+G F V++A + N VA+K + S E+K + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS-----------WEVKAM 65 Query: 67 QELSHPNIIGLLDAFGHKSNIS-----LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 L + N++ LL LV FME + + + Sbjct: 66 VNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEV 125 Query: 122 LQGLEYLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAK------SFGSPNRAYTHQV 173 + G+ YLH +LHRDLKP+N+LLD KLADFGL+ S Sbjct: 126 VLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSG 185 Query: 174 VTRWYRAPELLFGAR-MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 T Y PELLF D+++ G ++ +L +D+ + I ET Sbjct: 186 GTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE----AELVDKTSLIRET---- 237 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 + D + +P + + L +L+ + R + Sbjct: 238 ----------VCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDC 284 >2H34-A nrPDB Length = 309 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 52/223 (23%), Positives = 84/223 (37%), Gaps = 4/223 (1%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y +G G VY+A D +IVA+K + S+ RE + L Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSD--PVFRTRMQREARTAGRLQE 93 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQH 131 P+++ + D + + + + L P A + L+ H Sbjct: 94 PHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAA 153 Query: 132 WILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN-RAYTHQVVTRWYRAPELLFGARMY 190 HRD+KP N+L+ + L DFG+A + + V T +Y APE F Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FSESHA 212 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT 233 D++A+ C+L E L P GD I + + P+ Sbjct: 213 TYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >5AR8-A nrPDB Length = 326 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 114/292 (39%), Gaps = 24/292 (8%) Query: 15 LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNI 74 L +L G TV AR + VA+K + + + D + LRE ++L + I Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHI--HTPLLDSERKDVLREAEILHKARFSYI 94 Query: 75 IGLLDAFGHKSNISLVFDFM-ETDLEVIIKDNSLVLTPSHIKAY--MLMTLQGLEYLHQH 131 + +L + +V ++M L ++ + + + + G+ YLH Sbjct: 95 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNM 154 Query: 132 W--ILHRDLKPNNLLLDENGVLKLADFGLAK-----SFGSPNRAYTHQVVTRWYRAPELL 184 +LH DLK N+LLD +K+ADFGL+K S + + T Y PE Sbjct: 155 TPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 214 Query: 185 F--GARMYGVGVDMWAVGCILAELLLRV-PFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241 + D+++ I E+L R PF + L + + + E+ Sbjct: 215 EPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEE----- 269 Query: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCAR----ITATQA 289 SLP + ++ + ++ D+ ++ L P R IT +A Sbjct: 270 SLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEA 321 >5VC6-A nrPDB Length = 289 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 58/317 (18%), Positives = 112/317 (35%), Gaps = 62/317 (19%) Query: 2 ALDVKSR-AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 A +KSR + +L+ +G G+F +V+K + I AIK+ + A + AL Sbjct: 2 AGSMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR---SKKPLAGSVDEQNAL 58 Query: 61 REIKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLV---LTPSHIK 115 RE+ L H +++ A+ ++ + ++ L I +N + + +K Sbjct: 59 REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELK 118 Query: 116 AYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVL-------------------KLADF 156 +L +GL Y+H ++H D+KP+N+ + + K+ D Sbjct: 119 DLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDL 178 Query: 157 GLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGD 216 G SP + A E+L + D++A+ + LP Sbjct: 179 GHVTRISSPQVEEGDS----RFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLP-- 231 Query: 217 SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 + DQ I + L I + +L++ + Sbjct: 232 RNGDQWHEIRQGR---------------------------LPRIPQVLSQEFTELLKVMI 264 Query: 277 LFNPCARITATQALKMK 293 +P R +A +K Sbjct: 265 HPDPERRPSAMALVKHS 281 >5VDK-A nrPDB Length = 297 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 58/313 (18%), Positives = 111/313 (35%), Gaps = 69/313 (22%) Query: 7 SRAKRYEK----LDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 + A RYEK ++ +G G+F TVYK + + AIK+ + + +AL E Sbjct: 8 NMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNEN---SALHE 64 Query: 63 IKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLV---LTPSHIKAY 117 + L HP+++ ++ ++ + ++ L+ I +N+ +K Sbjct: 65 VYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDI 124 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNL-----------------------LLDENGVLKLA 154 +L GL Y+H ++H D+KP+N+ L N + K+ Sbjct: 125 LLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIG 184 Query: 155 DFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLP 214 D G A S P + A E+L + D++A+G +A Sbjct: 185 DLGHATSINKPKVEEGDS----RFLANEILQEDYRHLPKADIFALGLTIAV--------- 231 Query: 215 GDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQG 274 E P + ++ +FP +P + L++ Sbjct: 232 ----------------AAGAESLPTNGAAWHHIRKGNFPDVP-----QELSESFSSLLKN 270 Query: 275 LFLFNPCARITAT 287 + + R +A Sbjct: 271 MIQPDAEQRPSAA 283 >3QD2-B nrPDB Length = 332 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 66/356 (18%), Positives = 124/356 (34%), Gaps = 98/356 (27%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT------------ 58 +E + +G G F V++A++K + AIK+I+L +R A++ + R Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 59 --------------ALRE---------------------------IKLLQELSHPNIIGL 77 E I+ + S N +G Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 78 LDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSH--IKAYMLMTLQGLEYLHQHWIL 134 L K + + +L+ + + H + + +E+LH ++ Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLM 186 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR------------AYTHQVVTRWYRAPE 182 HRDLKP+N+ + V+K+ DFGL + +T QV T+ Y +PE Sbjct: 187 HRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPE 246 Query: 183 LLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 + G Y VD++++G IL ELL + ++++ I + Sbjct: 247 QIHGNN-YSHKVDIFSLGLILFELLYSF-----STQMERVRIITDVR------------- 287 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 + +F+ ++Q + +P R AT ++ F N Sbjct: 288 -----------NLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIFENL 332 >5J0A-A nrPDB Length = 300 Score = 151 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 57/292 (19%), Positives = 112/292 (38%), Gaps = 33/292 (11%) Query: 22 QFAT---VYKARDKNTNQ---IVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 F T VY + A+KKI + + + E K+L+ L HPNI+ Sbjct: 18 GFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIV 77 Query: 76 GLLDAFGH--KSNISLVFDF-METDLEVIIKDNSL----VLTPSHIKAYMLMTLQGLEYL 128 G AF ++ L ++ E L +I++ + I L +GL+YL Sbjct: 78 G-YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYL 136 Query: 129 H-QHWILHRDLKPNNLLLDENG-VLKLADFGLAKSFGSPNRAYTH---QVVTRWYRAPEL 183 H + +LH D+K +N+++ + +K+ D G++ + T ++ E Sbjct: 137 HQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEA 196 Query: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 + + D++A G L E++ +P + +D D + F+ E + + + Sbjct: 197 VEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGT 256 Query: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT---QALK 291 P + +++L +P R +A +AL+ Sbjct: 257 RP----------PINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >2CHL-A nrPDB Length = 351 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 106/280 (37%), Gaps = 28/280 (10%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 + +G G F + ++ TN+ VAIK + R+ E + ++L Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAP-------QLHLEYRFYKQLG 83 Query: 71 HPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129 + I + FG + +V + + LE + + + + + +EY+H Sbjct: 84 SGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVH 143 Query: 130 QHWILHRDLKPNNLLLDENG-----VLKLADFGLAKSFGSPN-------RAYTHQVVTRW 177 +++RD+KP N L+ G V+ + DF LAK + P R + T Sbjct: 144 SKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTAR 203 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTRIFETLG-TPT 233 Y + G D+ A+G + L G D+ ++ +I +T TP Sbjct: 204 YMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 262 Query: 234 E---EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 E E +P+M + YV F P + DL D Sbjct: 263 EVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFD 302 >4MWI-A nrPDB Length = 294 Score = 144 bits (364), Expect = 4e-35, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 107/281 (38%), Gaps = 44/281 (15%) Query: 24 ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGH 83 +T+YK VAIK K ++ + + +T +EIK +++ PNI+ + Sbjct: 38 STLYKGEYHRA--PVAIKVFKKL-QAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICID 94 Query: 84 K----SNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI--LHRD 137 + S+V ++ E + D LT +L +GL LH LH Sbjct: 95 ETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGK 154 Query: 138 LKPNNLLLDENGVLKLADFGLAKSFGS----PNRAYTHQVVTRWYRAPELLFGA-RMYGV 192 ++ +N L+ + +KLA F L K+ S R T +V + Y +P+ L Y V Sbjct: 155 IRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDV 214 Query: 193 GVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGT--PTEEQWPDMCSLPDYVTFK 250 ++++ G +L E+ G + +++ ++ P E P Sbjct: 215 KSEIYSFGIVLWEIATGDIPFQG-CNSEKIRKLVAVKRQQEPLGEDCP------------ 261 Query: 251 SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 +L ++I +P R + + LK Sbjct: 262 ---------------SELREIIDECRAHDPSVRPSVDEILK 287 >4M69-B nrPDB Length = 283 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 53/277 (19%), Positives = 97/277 (35%), Gaps = 38/277 (13%) Query: 24 ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGH 83 +T+Y+ + V IK ++E+ + T EIK +++ PNI+ + Sbjct: 23 STIYRGEYHRS--PVTIKVFN-NPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 79 Query: 84 ----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLK 139 S+V ++ E + D LT S +L +GL LH LHR++ Sbjct: 80 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 139 Query: 140 PNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW----YRAPELLFG-ARMYGVGV 194 ++ L+ +KLA F L+K+ S +R R Y +PE L +Y + Sbjct: 140 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKA 199 Query: 195 DMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG 254 ++++ G +L E+ G + E Sbjct: 200 EIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE--------------------------D 233 Query: 255 IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 + + L ++I P R + L+ Sbjct: 234 KKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 270 >4BTF-A nrPDB Length = 469 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 53/277 (19%), Positives = 97/277 (35%), Gaps = 38/277 (13%) Query: 24 ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGH 83 +T+Y+ + V IK ++E+ + T EIK +++ PNI+ + Sbjct: 209 STIYRGEYHRS--PVTIKVFN-NPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 265 Query: 84 ----KSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLK 139 S+V ++ E + D LT S +L +GL LH LHR++ Sbjct: 266 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNIS 325 Query: 140 PNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW----YRAPELLFG-ARMYGVGV 194 ++ L+ +KLA F L+K+ S +R R Y +PE L +Y + Sbjct: 326 SSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKA 385 Query: 195 DMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG 254 ++++ G +L E+ G + E Sbjct: 386 EIYSFGIVLWEIATGKIPFEGCDSKKIRELVAE--------------------------D 419 Query: 255 IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 + + L ++I P R + L+ Sbjct: 420 KKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILE 456 >4L00-A nrPDB Length = 304 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 106/294 (36%), Gaps = 49/294 (16%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKAR------DKNTNQIVAIKKIKLGHRSEAKDGINRTA 59 + K + + LG G +Y D+ T++ IK I L + I+ Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVI-LKVLDPSHRDISLAF 79 Query: 60 LREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYM 118 +++++SH +I+ L +V +F+E L++ + S VLT Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVA 139 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDENGV-------LKLADFGLAKSFGSPNRAYTH 171 L YL ++H ++ NLLL G+ +KL+D G+ + S Sbjct: 140 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLS-----RQ 194 Query: 172 QVVTR-WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 + + R + APE + ++ V D W+ G L E+ D L + R +E+ Sbjct: 195 ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRC 254 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 P + + +L DL+ ++P R Sbjct: 255 RP----------------------------VTPSCKELADLMTRCMNYDPNQRP 280 >5X1R-A nrPDB Length = 302 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 110/291 (37%), Gaps = 26/291 (8%) Query: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGIN----- 56 +L R +E + +GEG F VY+A D + +AIK+ ++ D ++ Sbjct: 13 SLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRG 72 Query: 57 -----------RTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKD 104 + ++E +LL SHP ++ +L + + F L+ + Sbjct: 73 ERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQ 132 Query: 105 NSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGS 164 + + I+ + + +HQ LHRD+ +N+ + E+ + L DFG A+ Sbjct: 133 QPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIG 192 Query: 165 PNRAYTHQVVTRWYRAPELLFGARM--YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL 222 T V+ + E G D++A+G +L L++ P + Sbjct: 193 NLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVS------V 246 Query: 223 TRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQ 273 R E P E+ P S P+ + D++ +L++ Sbjct: 247 VRSIEDSYQPLTERRPAGYS-PELLRTVDRALALKPEDRPQTIDEMAELLE 296 >3SV0-A nrPDB Length = 483 Score = 141 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 61/297 (20%), Positives = 104/297 (35%), Gaps = 43/297 (14%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 ++ +G G F +Y + TN+ VAIK + + + L E K+ + Sbjct: 6 GNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTK-------HPQLLYESKIYRI 58 Query: 69 LSH----PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 L PN + LV D + LE + S L+ + + Sbjct: 59 LQGGTGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINR 115 Query: 125 LEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181 +E++H LHRD+KP+N L+ + + DFGLAK + T YR Sbjct: 116 VEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRD-----TSTHQHIPYREN 170 Query: 182 ELLFGARMY-----------GVGVDMWAVG-CILAELLLRVPF--LPGDSDLDQLTRIFE 227 + L G Y D+ ++G ++ L +P+ L + + +I E Sbjct: 171 KNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 Query: 228 -----TLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN 279 ++ + S Y F P + DL I+ F F+ Sbjct: 231 KKVATSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDL--FIREGFQFD 285 >2C47-A nrPDB Length = 313 Score = 141 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 62/285 (21%), Positives = 107/285 (37%), Gaps = 29/285 (10%) Query: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLL 66 S + +G G F + ++ TN+ VAIK + R+ E + Sbjct: 1 SMGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAP-------QLHLEYRFY 53 Query: 67 QELSHPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125 ++LS + + FG + +V + + LE + T + + + + Sbjct: 54 KQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRM 113 Query: 126 EYLHQHWILHRDLKPNNLLLDENGV-----LKLADFGLAKSFGSPN-------RAYTHQV 173 EY+H +++RD+KP N L+ G + + DFGLAK + P R + Sbjct: 114 EYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLT 173 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTRIFETLG 230 T Y + G D+ A+G + L G D+ ++ +I +T Sbjct: 174 GTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 232 Query: 231 -TPTE---EQWP-DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 TP E E +P +M + YV F P + DL D Sbjct: 233 ATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFD 277 >2PZI-A nrPDB Length = 681 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 61/239 (25%), Positives = 104/239 (43%), Gaps = 24/239 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKN-TNQIVAIKKIKLGHRSEAKDGINRTALRE 62 A +YE + G +Y A D+N + V +K L H +A+ A R Sbjct: 74 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLK--GLVHSGDAEAQAMAMAER- 130 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNI-----SLVFDFMETDLEVIIKDNSLVLTPSHIKAY 117 + L E+ HP+I+ + + H +V +++ + + + L + AY Sbjct: 131 -QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAY 187 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 +L L L YLH +++ DLKP N++L E LKL D G S Y T Sbjct: 188 LLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPG 242 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVP-----FLPGDSDLDQLTRIFETLGT 231 ++APE++ V D++ VG LA L L +P ++ G + D + + +++ G Sbjct: 243 FQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGR 299 >4Y12-A nrPDB Length = 375 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 61/239 (25%), Positives = 104/239 (43%), Gaps = 24/239 (10%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKN-TNQIVAIKKIKLGHRSEAKDGINRTALRE 62 A +YE + G +Y A D+N + V +K L H +A+ A R Sbjct: 113 PGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLK--GLVHSGDAEAQAMAMAER- 169 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNI-----SLVFDFMETDLEVIIKDNSLVLTPSHIKAY 117 + L E+ HP+I+ + + H +V +++ + + + L + AY Sbjct: 170 -QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG--QSLKRSKGQKLPVAEAIAY 226 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW 177 +L L L YLH +++ DLKP N++L E LKL D G S Y T Sbjct: 227 LLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPG 281 Query: 178 YRAPELLFGARMYGVGVDMWAVGCILAELLLRVP-----FLPGDSDLDQLTRIFETLGT 231 ++APE++ V D++ VG LA L L +P ++ G + D + + +++ G Sbjct: 282 FQAPEIVRTGP--TVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGR 338 >5FQD-C nrPDB Length = 341 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 73/365 (20%), Positives = 127/365 (34%), Gaps = 56/365 (15%) Query: 1 MALDVKSRAK-----RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGI 55 MA S+A+ +Y+ + +G G F +Y A + + VA+K E++ Sbjct: 5 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-------LESQKAR 57 Query: 56 NRTALREIKLLQELSH----PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTP 111 + L E KL + L P+I K LV D + LE + S T Sbjct: 58 HPQLLYESKLYKILQGGVGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSRRFTM 114 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVL---KLADFGLAKSFGS---- 164 + + +EY+H +HRD+KP+N L+ L DFGLAK + Sbjct: 115 KTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTR 174 Query: 165 ---PNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVG-CILAELLLRVPF--LPGDSD 218 P R + T Y + G DM ++G ++ +P+ L + Sbjct: 175 QHIPYREDKNLTGTARYASINAHLGIEQ-SRRDDMESLGYVLMYFNRTSLPWQGLKAATK 233 Query: 219 LDQLTRIFE-TLGTPTEEQWPDMCS----LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQ 273 + +I E + TP E + +Y F P + ++ Sbjct: 234 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMY-----------LR 282 Query: 274 GLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTE 333 LF RI + L +Y + + +Q+ + +T+ Sbjct: 283 QLF------RI-LFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTK 335 Query: 334 ALEQG 338 + +G Sbjct: 336 SNMKG 340 >2CMW-A nrPDB Length = 310 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 103/280 (36%), Gaps = 30/280 (10%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH- 71 +G G F + ++ TN+ VAIK + R+ E + ++L Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAP-------QLHLEYRFYKQLGSA 55 Query: 72 -PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130 + + ++V + + LE + T + + L +EY+H Sbjct: 56 GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 115 Query: 131 HWILHRDLKPNNLLLDENG-----VLKLADFGLAKSFGSPN-------RAYTHQVVTRWY 178 +++RD+KP N L+ G V+ + DFGLAK + P R + T Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTRIFETLG-TPTE 234 + G D+ A+G + L G D+ ++ +I +T TP E Sbjct: 176 MSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIE 234 Query: 235 ---EQWP-DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 E +P +M + YV F P + DL + Sbjct: 235 ALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFE 274 >4TN6-A nrPDB Length = 318 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 106/287 (36%), Gaps = 28/287 (9%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 ++++ RY +G G F +Y D + VAIK E + E Sbjct: 1 MELRV-GNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-------LECVKTKHPQLHIE 52 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 K+ + + I + G + + + +V + + LE + S + + Sbjct: 53 SKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQM 112 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGS-------PNRAYTH 171 + +EY+H +HRD+KP+N L+ + ++ + DFGLAK + P R + Sbjct: 113 ISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKN 172 Query: 172 QVVTRWYRAPELLFGARMYGVGVDMWAVG-CILAELLLRVPF--LPGDSDLDQLTRIFE- 227 T Y + G D+ ++G ++ L +P+ L + + RI E Sbjct: 173 LTGTARYASINTHLGIEQ-SRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEK 231 Query: 228 TLGTPTEEQWP----DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 + TP E + + ++ F P + +L Sbjct: 232 KMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFH 278 >5L2Q-C nrPDB Length = 320 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 97/301 (32%), Gaps = 62/301 (20%) Query: 27 YKARDKNTNQIVAIKKIKLGHR----SEAKDGINRTAL--REIKLLQELS-HPNIIGLLD 79 AR T+ +K + L R E+++ L E LL L ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 80 AFGH------------------KSNISLVFD-FMETDLEV---------IIKDNSLVLTP 111 F K I LV D D L+ Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV-LKLADFGLAKSFGSPNRAYT 170 ++ +E LHQ I+HRDLK N++L++ + + +F L K S Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 171 HQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 Q + Y +P++L G G DMWA+G +L +L + +I Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQAL 290 T E+ ++ + LI+ L + +P R+ A L Sbjct: 273 TIPED--------------------------GRVSENTVCLIRKLLVLDPQQRLAAADVL 306 Query: 291 K 291 + Sbjct: 307 E 307 >3HNG-A nrPDB Length = 360 Score = 136 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 88/216 (40%), Gaps = 39/216 (18%) Query: 81 FGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKP 140 F ++S V + E D + K+ +T + +Y +G+E+L +HRDL Sbjct: 173 FQEDKSLSDVEE--EEDSDGFYKE---PITMEDLISYSFQVARGMEFLSSRKCIHRDLAA 227 Query: 141 NNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGVGVDMW 197 N+LL EN V+K+ DFGLA+ N Y + TR + APE +F ++Y D+W Sbjct: 228 RNILLSENNVVKICDFGLARDIYK-NPDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVW 285 Query: 198 AVGCILAELLL--RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGI 255 + G +L E+ P+ D D +R+ E + E Sbjct: 286 SYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEY------------------- 326 Query: 256 PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALK 291 + ++ ++ + +P R + ++ Sbjct: 327 --------STPEIYQIMLDCWHRDPKERPRFAELVE 354 Score = 74.1 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 47/108 (43%), Gaps = 12/108 (11%) Query: 10 KRYEKLDFLGEGQFATVYKA-----RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 +R + LG G F V +A + T + VA+K +K G A + + E+K Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG----ATASEYKALMTELK 82 Query: 65 LLQELSHP-NIIGLLDAFG-HKSNISLVFDFME-TDLEVIIKDNSLVL 109 +L + H N++ LL A + ++ ++ + +L +K + Sbjct: 83 ILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLF 130 >3VHK-A nrPDB Length = 368 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 45/192 (23%), Positives = 74/192 (38%), Gaps = 32/192 (16%) Query: 105 NSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFG- 163 LT H+ Y +G+E+L +HRDL N+LL E V+K+ DFGLA+ Sbjct: 193 YKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK 252 Query: 164 SPNRAYTHQVVTRW-YRAPELLFGARMYGVGVDMWAVGCILAELLL--RVPFLPGDSDLD 220 P+ + APE +F R+Y + D+W+ G +L E+ P+ D + Sbjct: 253 DPDYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE 311 Query: 221 QLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNP 280 R+ E PDY T ++ + + P Sbjct: 312 FCRRLKEGTRM----------RAPDYTT-----------------PEMYQTMLDCWHGEP 344 Query: 281 CARITATQALKM 292 R T ++ ++ Sbjct: 345 SQRPTFSELVEH 356 Score = 74.5 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 28/110 (25%), Positives = 48/110 (43%), Gaps = 12/110 (10%) Query: 10 KRYEKLDFLGEGQFATVYKA----RDK-NTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 R + LG G F V +A DK T + VA+K +K G A +R + E+K Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEG----ATHSEHRALMSELK 84 Query: 65 LLQELSHP-NIIGLLDAFGHK-SNISLVFDFME-TDLEVIIKDNSLVLTP 111 +L + H N++ LL A + ++ +F + +L ++ P Sbjct: 85 ILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 134 >3REP-A nrPDB Length = 271 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 56/292 (19%), Positives = 108/292 (36%), Gaps = 44/292 (15%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M K+ L L E ++K R + + +V + K++ +++D N Sbjct: 1 MNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD-FNEECP 59 Query: 61 REIKLLQELSHPNIIGLLDAFGHKS--NISLVFDFME-TDLEVIIKDN-SLVLTPSHIKA 116 R L+ SHPN++ +L A + +L+ +M L ++ + + V+ S Sbjct: 60 R----LRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVK 115 Query: 117 YMLMTLQGLEYLH--QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV 174 + L +G+ +LH + I L ++++DE+ +++ + SF SP R Y Sbjct: 116 FALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA---- 171 Query: 175 TRWYRAPELLFGARMYG--VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTP 232 + APE L DMW+ +L EL+ R S+++ ++ Sbjct: 172 -PAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKV------- 223 Query: 233 TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 P IP + L++ +P R Sbjct: 224 --------------ALEGLRPTIP-----PGISPHVSKLMKICMNEDPAKRP 256 >4JRN-A nrPDB Length = 372 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 75/343 (21%), Positives = 110/343 (32%), Gaps = 88/343 (25%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS------- 70 LG G FATVY+A D TN+ +A+K E D RE + S Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEK--EPTDETMLDLQRESSCYRNFSLAKTAKD 133 Query: 71 ----------------------HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKD---- 104 +IGL + N L+ E D+ +I Sbjct: 134 AQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWV--PNYFLLMMRAEADMSKVISWVFGD 191 Query: 105 ---NSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKS 161 N ++ + + I+H D+KP N LL ++G L L DFG + Sbjct: 192 ASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI 251 Query: 162 FGSPNRAYTHQVVTRWYRAPELLFGARM--YGVGVDMWAVGCILAELLLRVPFLPGDSDL 219 S RA + T Y PE F A Y D W +G L + + P D Sbjct: 252 NNSVGRA----IGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPAD--- 304 Query: 220 DQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFN 279 + DY+ F P P + + DLI+ L + Sbjct: 305 ----------------------GIWDYLHFADCPSTP---------ELVQDLIRSLLNRD 333 Query: 280 PCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSN 322 P R+ QAL+ F G + ++Q + Sbjct: 334 PQKRMLPLQALETAAFKEMDSVVKG--------AAQNFEQQEH 368 >6DC0-A nrPDB Length = 292 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 86/275 (31%), Gaps = 42/275 (15%) Query: 26 VYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKS 85 V +A +T + + K + H + + SH NI G+++ ++ Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLP----------SHSNITGIVEVILGET 71 Query: 86 NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL 145 + F+ D+ ++ L + + + HQ I+ DLK + Sbjct: 72 KAYVFFEKDFGDMHSYVRSRKR-LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 130 Query: 146 D--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY-GVGVDMWAVGCI 202 E L+L + A + + Y +PE+L Y G D+W++G + Sbjct: 131 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190 Query: 203 LAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS 262 L LL+ ++I E Sbjct: 191 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH--------------------------- 223 Query: 263 AAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 LI+ L P R+TA + L +F + Sbjct: 224 -ISPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 >5M07-A nrPDB Length = 276 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 55/218 (25%), Positives = 83/218 (38%), Gaps = 23/218 (10%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 MAL Y + LG VY + A+K + A D R Sbjct: 21 MALASGVTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPA--MAADDEFRRRFQ 78 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDN-SLVLTPSHIKAYM 118 RE ++ L HP+I+ + D + + D+++ D + D VL + A + Sbjct: 79 RETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIV 138 Query: 119 LMTLQGLEYLHQHWILHRDLKPNNLLLDE----NGVLKLADFGLAKSFGSPNRAYTHQVV 174 L+Y HQ +LHRD+ P N++L + + LADFG+A Sbjct: 139 TAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------- 185 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPF 212 Y APEL GA + G D +A+ L P Sbjct: 186 -PSYPAPELSAGADVDGR-ADQYALALTAIHLFAGAPP 221 >5CEK-A nrPDB Length = 263 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 46/275 (16%), Positives = 86/275 (31%), Gaps = 42/275 (15%) Query: 26 VYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKS 85 V +A +T + + K + H + + SH NI G+++ ++ Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLP----------SHSNITGIVEVILGET 74 Query: 86 NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL 145 + F+ D+ ++ L + + + HQ I+ DLK + Sbjct: 75 KAYVFFEKDFGDMHSYVRSRKR-LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 133 Query: 146 D--ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMY-GVGVDMWAVGCI 202 E L+L + A + + Y +PE+L Y G D+W++G + Sbjct: 134 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193 Query: 203 LAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFS 262 L LL+ ++I E Sbjct: 194 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH--------------------------- 226 Query: 263 AAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 LI+ L P R+TA + L +F + Sbjct: 227 -ISPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 >4RT7-A nrPDB Length = 415 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 27/218 (12%) Query: 61 REIKLLQELSHPN---IIGLLD-AFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKA 116 RE+++ HP+ I GL +F + I ++ E + +++ VLT + Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEI----EY-ENQKRLEEEEDLNVLTFEDLLC 247 Query: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY---THQV 173 + +G+E+L +HRDL N+L+ V+K+ DFGLA+ S + ++ Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLR----VPFLPGDSDLDQLTRIFETL 229 +W APE LF +Y + D+W+ G +L E+ P +P D++ +L + + Sbjct: 308 PVKW-MAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKM 365 Query: 230 GTP---TEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAA 264 P TEE + M S + + K P P F Sbjct: 366 DQPFYATEEIYIIMQSCWAFDSRK-RPSFPNLTSFLGC 402 Score = 88.8 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 27/107 (25%), Positives = 43/107 (40%), Gaps = 11/107 (10%) Query: 10 KRYEKLDFLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIK 64 + E LG G F V A + VA+K +K +A + E+K Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK----EKADSSEREALMSELK 120 Query: 65 LLQEL-SHPNIIGLLDAFGHKSNISLVFDF-METDLEVIIKDNSLVL 109 ++ +L SH NI+ LL A I L+F++ DL ++ Sbjct: 121 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKF 167 >4NT4-A nrPDB Length = 312 Score = 131 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 102/289 (35%), Gaps = 39/289 (13%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL- 69 + +G G F + ++ N+ VAIK + ++ E + + L Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAP-------QLHLEYRFYKLLG 65 Query: 70 SH--------PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 SH P I L G + N ++V + + LE + + + + Sbjct: 66 SHADNAPDGIPRIYHL-GTCGGRYN-AMVLELLGLSLEDLFNICARKFSLKTVLMIAKQL 123 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGV-----LKLADFGLAKSFGS-------PNRAY 169 L +EY+H +++RD+KP N L+ + + DFGLAK + P R + Sbjct: 124 LHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREH 183 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTRIF 226 T Y + G D+ A+G + L G D+ ++ +I Sbjct: 184 KSLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIG 242 Query: 227 ETLG-TPTEEQWP----DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 +T TP E + + YV F P + DL D Sbjct: 243 DTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLFD 291 >5X18-A nrPDB Length = 295 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 99/282 (35%), Gaps = 31/282 (10%) Query: 11 RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70 Y+ +GEG F +++ + VAIK E + E K + L+ Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF-------EPRKTEAPQLRDEYKTYKILN 60 Query: 71 H-PNIIGLLDAFGHKS-NISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 PNI FG + + LV D + LE + + + + + +E L Sbjct: 61 GTPNI-PYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDL 119 Query: 129 HQHWILHRDLKPNNLLLDENGV-----LKLADFGLAKSFGSPN-------RAYTHQVVTR 176 H H +++RD+KP+N L+ G + L DFG+AK + P R T Sbjct: 120 HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTA 179 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTRIFETLGTPT 233 Y + G DM A+G + L G ++ + +I E + Sbjct: 180 RYMSINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTN 238 Query: 234 EEQWPDMCSLP-----DYVTFKSFPGIPLHHIFSAAGDDLLD 270 + + V SF P + + +LD Sbjct: 239 VYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLD 280 >5USZ-A nrPDB Length = 289 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 49/296 (16%), Positives = 97/296 (32%), Gaps = 53/296 (17%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTN-------QIVAIKKIKLGHRSEAKDGINRT 58 K R + + LG+G F ++K + V +K + HR + + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHR-----NYSES 58 Query: 59 ALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAY 117 ++ +LSH +++ LV +F++ L+ +K N + Sbjct: 59 FFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEV 118 Query: 118 MLMTLQGLEYLHQHWILHRDLKPNNLLL--------DENGVLKLADFGLAKSFGSPNRAY 169 + +L ++ ++H ++ N+LL +KL+D G++ + P Sbjct: 119 AKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVL-PKDIL 177 Query: 170 THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 ++ + PE + + + D W+ G L E+ GD L L Sbjct: 178 QERIP---WVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSAL------- 222 Query: 230 GTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARIT 285 L Y P +L +LI + P R + Sbjct: 223 --------DSQRKLQFYEDRHQLPAPK--------AAELANLINNCMDYEPDHRPS 262 >4XHH-A nrPDB Length = 403 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 102/289 (35%), Gaps = 36/289 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 +D++ +++ +G G F +Y + + + VAI+ + R D E Sbjct: 1 MDLRV-GRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDY-------E 52 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + LS I + FG + + +V D + LE + + + L Sbjct: 53 SRVYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQM 112 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 + ++Y+H +HRD+KP+N L+ + + DFGL+K + N Y Sbjct: 113 ICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHR-----HIPY 167 Query: 179 RAPELLFGARMY-----------GVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTR 224 R + L G Y D+ ++G +L G + + R Sbjct: 168 RENKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDR 227 Query: 225 IFETLGTPTEEQW-----PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDL 268 I E + E + +Y F P + + DL Sbjct: 228 ILEKKLCISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDL 276 >4BTK-A nrPDB Length = 337 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 90/233 (38%), Gaps = 22/233 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 R++ L +G G F +Y+A D T + VA+K E+ + E+ +L++L Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-------ESAQQPKQVLKMEVAVLKKL 108 Query: 70 S-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEY 127 ++ + ++ +V +L + + T S L+ +E Sbjct: 109 QGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEA 168 Query: 128 LHQHWILHRDLKPNNL----LLDENGVLKLADFGLAKSFGS------PNRAYTHQVVTRW 177 +H LHRD+KP+N L + DFGLA+ + + P R T Sbjct: 169 IHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 228 Query: 178 YRAPEL-LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 Y + + R G D+W++ +L E + D +Q+ I E Sbjct: 229 YAS--VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKY 279 >4XHL-A nrPDB Length = 394 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 100/289 (34%), Gaps = 36/289 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 +D++ +++ +G G F +Y + + + VAI+ + R D E Sbjct: 1 MDLRV-GRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDY-------E 52 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNIS-LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 ++ + LS I + FG + + +V D + LE + + + L Sbjct: 53 SRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQM 112 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD---ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY 178 ++Y+H +HRD+KP+N L+ + + DFGL+K + N Y Sbjct: 113 FCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHR-----HIPY 167 Query: 179 RAPELLFGARMY-----------GVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTR 224 R + L G Y D+ ++G +L G + + R Sbjct: 168 RENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDR 227 Query: 225 IFETLGTPTEEQW-----PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDL 268 I E + E + Y F P + + DL Sbjct: 228 IMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 >4NFN-A nrPDB Length = 309 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 50/233 (21%), Positives = 90/233 (38%), Gaps = 22/233 (9%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 R++ L +G G F +Y+A D T + VA+K E+ + E+ +L++L Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-------ESAQQPKQVLKMEVAVLKKL 73 Query: 70 S-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEY 127 ++ + ++ +V +L + + T S L+ +E Sbjct: 74 QGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEA 133 Query: 128 LHQHWILHRDLKPNNL----LLDENGVLKLADFGLAKSFGS------PNRAYTHQVVTRW 177 +H LHRD+KP+N L + DFGLA+ + + P R T Sbjct: 134 IHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVR 193 Query: 178 YRAPEL-LFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETL 229 Y + + R G D+W++ +L E + D +Q+ I E Sbjct: 194 YAS--VNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKY 244 >1CSN-A nrPDB Length = 298 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 102/291 (35%), Gaps = 29/291 (9%) Query: 1 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL 60 M+ Y+ +GEG F +++ + NQ VAIK RS+A R Sbjct: 1 MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF--EPRRSDAPQL--RDEY 56 Query: 61 REIKLLQELSH-PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYML 119 R KLL + PN+ + LV D + LE ++ + + Sbjct: 57 RTYKLLAGCTGIPNV---YYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAK 113 Query: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGV-----LKLADFGLAKSFGS-------PNR 167 L ++ +H+ +++RD+KP+N L+ + + DFG+ K + P R Sbjct: 114 QMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYR 173 Query: 168 AYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPG---DSDLDQLTR 224 + T Y + G D+ A+G + L G ++ + R Sbjct: 174 EKKNLSGTARYMSINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYER 232 Query: 225 IFETL-GTPTEEQW----PDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 I E TP E + Y +F P + +L+ Sbjct: 233 IGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLE 283 >5C01-A nrPDB Length = 342 Score = 116 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 55/319 (17%), Positives = 101/319 (31%), Gaps = 70/319 (21%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKAR------------------------DKNTNQIVAIK 41 + K +L LG+G VY+ R D+ V +K Sbjct: 54 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 113 Query: 42 KIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEV 100 + H I L+ ++SH ++ + +V +++E L+V Sbjct: 114 VLDPSHH-----DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 168 Query: 101 IIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV-------LKL 153 ++ + + L YL ++H ++ N+LL G+ +KL Sbjct: 169 WLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL 228 Query: 154 ADFGLAKSFGSPNRAYTHQVVTRWYRAPELL-FGARMYGVGVDMWAVGCILAELLLRVPF 212 +D G G + +V + APE L GA +D W G L E+ Sbjct: 229 SDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC----- 279 Query: 213 LPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLI 272 G++ L +P+E++ H + + L L Sbjct: 280 FDGEAPLQ--------SRSPSEKE---------------HFYQRQHRLPEPSCPQLATLT 316 Query: 273 QGLFLFNPCARITATQALK 291 + P R + L+ Sbjct: 317 SQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 55/319 (17%), Positives = 101/319 (31%), Gaps = 70/319 (21%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKAR------------------------DKNTNQIVAIK 41 + K +L LG+G VY+ R D+ V +K Sbjct: 31 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 90 Query: 42 KIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEV 100 + H I L+ ++SH ++ + +V +++E L+V Sbjct: 91 VLDPSHH-----DIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 145 Query: 101 IIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGV-------LKL 153 ++ + + L YL ++H ++ N+LL G+ +KL Sbjct: 146 WLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL 205 Query: 154 ADFGLAKSFGSPNRAYTHQVVTRWYRAPELL-FGARMYGVGVDMWAVGCILAELLLRVPF 212 +D G G + +V + APE L GA +D W G L E+ Sbjct: 206 SDPG----VGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEIC----- 256 Query: 213 LPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLI 272 G++ L +P+E++ H + + L L Sbjct: 257 FDGEAPLQ--------SRSPSEKE---------------HFYQRQHRLPEPSCPQLATLT 293 Query: 273 QGLFLFNPCARITATQALK 291 + P R + L+ Sbjct: 294 SQCLTYEPTQRPSFRTILR 312 >4L68-A nrPDB Length = 340 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 105/275 (38%), Gaps = 19/275 (6%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 D+ + + + + + T YKA +A+K + E R E Sbjct: 33 GDLMAATNNFNSENIIVSTRTGTTYKAL-LPDGSALAVKHLSTCKLGE------REFRYE 85 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMT 121 + L EL H N+ LL + LV+ +M L ++ N L S L Sbjct: 86 MNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGA 145 Query: 122 LQGLEYLHQ---HWILHRDLKPNNLLLDENGVLKLADFGLAKSF----GSPNRAYTHQVV 174 +GL +LH ILH+++ + +L+DE+ ++ D GLA+ + + T + Sbjct: 146 ARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLG 205 Query: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQL---TRIFETLGT 231 Y APE + + D++ +G +L EL + + G+ L + E+ G Sbjct: 206 EFGYVAPEY-STTMLASLKGDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGR 264 Query: 232 PTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGD 266 E ++ F I L+ + S + Sbjct: 265 IAETFDENIRGKGHDEEISKFVEIALNCVSSRPKE 299 >5OAT-A nrPDB Length = 411 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 69/359 (19%), Positives = 114/359 (31%), Gaps = 96/359 (26%) Query: 14 KLDFLGEGQFATVYKARDKNTNQ-----IVAIKKIKLGHRSEAKDGINRTALRE------ 62 + +G VY A+ K+ A+K + E I + RE Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 63 -----------IKLLQELSH----PNIIGLLDAFGHKSN-----------------ISLV 90 I+L H PNI+ + F + L+ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 91 FDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD---- 146 + +L+ + T + A +L G+ ++ H I HRDLK +NLLLD Sbjct: 135 MKRYDCNLQSFLSTAPSTRTSLLLLAQLLE---GVAHMTAHGIAHRDLKSDNLLLDTSEP 191 Query: 147 ENGVLKLADFG--LAKSFGSPNRAYT----HQVVTRWYRAPELLFGARM------YGVGV 194 E+ +L ++DFG LA + YT + APE++ Y Sbjct: 192 ESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-KA 250 Query: 195 DMWAVGCILAELL-LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFP 253 D+WAVG I E+ PF P + ++ Sbjct: 251 DLWAVGAIAYEIFNCHNPFYG-----------------------------PSRLKNFNYK 281 Query: 254 GIPLHHIFSAAGDDLLDLIQGLFLFNPCARI---TATQALKMKYFSNRPGPTPGCQLPR 309 L + + L+ L NP R+ A ++ ++ PG ++P Sbjct: 282 EGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPEVAANVCQLFLWAPSTWLKPGLKVPT 340 >5UV4-A nrPDB Length = 311 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 44/206 (21%), Positives = 82/206 (39%), Gaps = 17/206 (8%) Query: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 + +G T YKA + ++ +K +K G K+ REIK L + HPN++ Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKE-----FSREIKKLGSVRHPNLV 84 Query: 76 GLLDAF--GHKSNISLVFDFMETD-----LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 L + + ++ D+ + L + N L+ + + L+YL Sbjct: 85 PLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYL 144 Query: 129 HQHWIL-HRDLKPNNLLL-DENGVLKLADFGLAKSFGSPNRA-YTHQVVTRWYRAPELLF 185 H ++ H ++K +N+L+ + + D+ L + A Y PE Sbjct: 145 HNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSS 204 Query: 186 GARMY-GVGVDMWAVGCILAELLLRV 210 ++ + D++A G IL ELL Sbjct: 205 TSKPCPSLKSDVYAFGVILLELLTGK 230 >6J6I-B nrPDB Length = 351 Score = 101 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 42/201 (20%), Positives = 71/201 (35%), Gaps = 11/201 (5%) Query: 30 RDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISL 89 R + ++ IK+ + + + + + +H N + LL L Sbjct: 76 RGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVL 135 Query: 90 VFDFMETDLEV-----IIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ---HWILHRDLKPN 141 VF+F E I+ +L S + YLH I+HRD+KP Sbjct: 136 VFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPM 195 Query: 142 NLLLDENGVLKLADFGLAKSFGSPNRAYTHQV--VTRWYRAPELLFGARMYGVGVDMWAV 199 ++ LD+N KL+D + S + T Y P L D+++ Sbjct: 196 HVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSF 254 Query: 200 GCILAELLLRVPFLPGDSDLD 220 G L ++ P + SD D Sbjct: 255 GICLLVIITGKPAIMTISDGD 275 >6G4J-A nrPDB Length = 315 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 81/228 (35%), Gaps = 31/228 (13%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Y LG+G VY A ++ VA+K + + E+ +L+ S Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV----------SDDSLSITSEVNVLKSFSK 75 Query: 72 PNIIGLLDAFGHKSNISL----------VFDFMETDLEVIIKDNSLVLTPSHIKAYMLMT 121 + + +F + + ++++ ++ I M+ Sbjct: 76 AQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKG---PLLLKYVSDKGAEWIPVLMIQL 132 Query: 122 LQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 L L LHQ + DLKP+NL++ ++ D G G + Y T +Y Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEY-----TEFYDR 187 Query: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFET 228 +G R D++AV I+ + + F + +QL + E Sbjct: 188 GYWGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEG 235 >4I94-A nrPDB Length = 300 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 95/264 (35%), Gaps = 38/264 (14%) Query: 25 TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK 84 VYK + +N + +A+K+ ++ R L E K + +L + + LL Sbjct: 44 VVYKGKLEN-QRRIAVKRFNRKSWPDS-----RQFLEEAKAVGQLRNHRMANLLGCCYED 97 Query: 85 SNISLVFDFMETDL--EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW-ILHRDLKPN 141 L+ +FM + + + S + + L Q LEY L+ DL Sbjct: 98 EERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAY 157 Query: 142 NLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGC 201 +L D++ +L+ FGL K+ T+ T PE L R+ +++ G Sbjct: 158 RVLFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLRTGRV-TPESVIYSFGT 212 Query: 202 ILAELLLRVPFLPGDS-DLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHI 260 +L +LL P + DL + I + + E Q+ Sbjct: 213 LLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQF----------------------- 249 Query: 261 FSAAGDDLLDLIQGLFLFNPCARI 284 S G +L+ L + P R Sbjct: 250 SSDDGTELIRLASRCLQYEPRERP 273 >6EQI-C nrPDB Length = 433 Score = 98.4 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 113/345 (32%), Gaps = 101/345 (29%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTN-----QIVAIKKIKLGHRSEAKDGINRTALRE-- 62 + + + +G A VY A+ KN +A+K + I + RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 63 -------------IKLLQELS-----HPNIIGLLDAFGHKSN------------------ 86 I+ + + HPNI+ + F + Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 87 ---------ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRD 137 + LV + L+ ++D + + S + L+ + + +++ H I HRD Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLL--EAVAHMNIHNISHRD 192 Query: 138 LKPNNLLLDEN-----GVLKLADFG--LAKSFGSPNRAYT----HQVVTRWYRAPELLFG 186 LK +N+L+D + + + DFG L Y + R APE+ Sbjct: 193 LKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANA 252 Query: 187 ARM------YGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Y D+WAVG I E+ PF + + L +E+ D Sbjct: 253 KPGTFSWLNY-KKSDLWAVGAIAYEIFNIDNPFYD---------KTMKLLSKSYKEE--D 300 Query: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI 284 + LPD + F + +L+ + + R+ Sbjct: 301 LPELPDTIPFI-----------------IRNLVSNMLSRSTNKRL 328 >5CLR-A nrPDB Length = 451 Score = 89.6 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 45/194 (23%), Positives = 76/194 (39%), Gaps = 24/194 (12%) Query: 27 YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSN 86 +K + + +K +K+ S + E L +L L+ F ++ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLTE------FTNEKDTLSKLG-----RLVGTFFNEQT 144 Query: 87 --ISLVFDFMET-DLEVIIKDNSLVLTPSH---IKAYMLMTLQGLEYLHQHWILHRDLKP 140 ++ F++ DL L + H + M+ ++ H+ ++HRDLKP Sbjct: 145 QVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 141 NNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM--YGVGVDMWA 198 N++LD + L DFG + S P A T Y APEL + D++A Sbjct: 205 GNIMLDADMQCHLVDFGSSSSDKEPKPA---SWGTASYLAPELNAQEDFIAFSQVSDLFA 261 Query: 199 VGCILAELLLRVPF 212 + L EL PF Sbjct: 262 LAYSLDELFN--PF 273 >5UU1-A nrPDB Length = 324 Score = 85.7 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 40/184 (21%), Positives = 72/184 (39%), Gaps = 26/184 (14%) Query: 6 KSRAKRYEKLDFLGEGQFATVYKAR-----DKNTNQIVAIK---------KIKLGHRSEA 51 ++ +G G F +Y A +K+ +V ++ ++K R Sbjct: 12 DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAK 71 Query: 52 KDGINRTALREIKLLQELSHPNIIGLLDA----FGHKSNISLVFDFMETDLEVIIKDNSL 107 KD I + R ++L + I + F +S +V + + DL+ I N Sbjct: 72 KDCIKKWIER-----KQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQNG- 125 Query: 108 VLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSP 165 S + + L LEY+H++ +H D+K NLLL + LAD+GL+ + Sbjct: 126 TFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPN 185 Query: 166 NRAY 169 Sbjct: 186 GNHK 189 >2RSV-A nrPDB Length = 403 Score = 85.7 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 29/180 (16%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIV------AIKK-----------IKLGHRSEAK 52 K ++ +G+G F +Y A D N+++ V +K +K R+ Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 53 DGINRTALREIKLLQELSHPNIIGLLDAFGHKSN----ISLVFDFMETDLEVIIKDNSLV 108 + I + + L+ L P + H N ++ D +DL+ I + N+ Sbjct: 101 EQIQKWIRT--RKLKYLGVP---KYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 155 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPN 166 + + L L LEY+H+H +H D+K +NLLL+ + L D+GLA + Sbjct: 156 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 215 >2LAV-A nrPDB Length = 361 Score = 84.9 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 42/180 (23%), Positives = 75/180 (41%), Gaps = 29/180 (16%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIV------AIKK-----------IKLGHRSEAK 52 K ++ +G+G F +Y A D N+++ V +K +K R+ Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 53 DGINRTALREIKLLQELSHPNIIGLLDAFGHKSN----ISLVFDFMETDLEVIIKDNSLV 108 + I + + L+ L P + H N ++ D +DL+ I + N+ Sbjct: 94 EQIQKWIRT--RKLKYLGVP---KYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKR 148 Query: 109 LTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLD--ENGVLKLADFGLAKSFGSPN 166 + + L L LEY+H+H +H D+K +NLLL+ + L D+GLA + Sbjct: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 >4IX6-A nrPDB Length = 350 Score = 76.5 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 106/330 (32%), Gaps = 71/330 (21%) Query: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPN--- 73 LG G F TV++ K +V ++ D + L E ++ H N Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV--------LKNAKADVMAAEELLECEMDVNYHVHANAKG 79 Query: 74 -IIGLLDAFG----HKSNIS--LVFD---FM-----ETDLEVIIKDNSLVLTPSHI---- 114 + I + + M E +E +++ + L + Sbjct: 80 TCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADA 139 Query: 115 ------KAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE--NGVLKLADFGLAKSFGSPN 166 K M L L LH+ ++HRD+KP NL+ E GVLKL D G A Sbjct: 140 TELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLP 199 Query: 167 RAYTHQVV-----TRWYRAPELLFGARMYGVGV----------------DMWAVGCILAE 205 + R+ +A EL D W+ GC++ + Sbjct: 200 ETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQ 259 Query: 206 LLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAG 265 L V L D+ L++ ++ +G + +Y T A G Sbjct: 260 LA--VVGLRTDAGLERFLADYKAVGYDVNAFRGEKSG--EYGTM-------DFAALDANG 308 Query: 266 DDLLDLIQGLFLFNPCARITATQALKMKYF 295 DL Q L AR + AL +F Sbjct: 309 GAGWDLCQRLMEAERDARASCEAALSHAFF 338 >4O1O-A nrPDB Length = 717 Score = 76.5 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 57/339 (16%), Positives = 108/339 (31%), Gaps = 93/339 (27%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 + Y+ D EG +Y ++ Q VA+K+ G + E+ LQ Sbjct: 350 EEYKIADT-AEGG---IYLGLYED--QEVAVKRFSEGSTRGQQ---------EVSCLQSS 394 Query: 70 S-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSH----IKAYMLMTLQG 124 + N++ + S + + E L+ + ++ P+ + + + Sbjct: 395 RANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKA 454 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELL 184 + LH+ H+DL+P N+L+D LADF + + + Sbjct: 455 IGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKR------------- 501 Query: 185 FGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 D+ A+G LL+ GD + L Sbjct: 502 ----------DLEALG-----LLVLYVVKKGDISFETLKN-------------------- 526 Query: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLF--NPCARITATQALKMKYFSNRPGPT 302 +SF + I + ++ DLI LF N R+++ L +F + Sbjct: 527 -----QSFEEV----IQGSPDEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSW---- 571 Query: 303 PGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLP 341 TL++ N + R + + Q P Sbjct: 572 --------ESRYRTLRDVGNESDIKTRNQNSRILQLLQP 602 >4CI6-B nrPDB Length = 643 Score = 70.7 bits (172), Expect = 8e-13, Method: Composition-based stats. Identities = 48/296 (16%), Positives = 98/296 (33%), Gaps = 52/296 (17%) Query: 32 KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-----SHPNIIGLLDA----FG 82 K+ ++VA K + E++ + + HPN+ + +G Sbjct: 66 KDKQRLVA-KI--------ERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYG 116 Query: 83 HKSNISLVFDFMET--------DLEVIIKDNSLVLT--PSHIKAYMLMTLQGLEYLHQHW 132 ++ +L+ D ++ L K + IK L +L + Sbjct: 117 NRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAG 176 Query: 133 ILHRDLKPNNLLLDE-NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYG 191 I+H D+KP N++ D +G + D GL G + +T ++APEL G Sbjct: 177 IVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES-----FKAPELGVGNLGAS 231 Query: 192 VGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKS 251 D++ +++ LL + D ++ + P Sbjct: 232 EKSDVF---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAH--------------VMD 274 Query: 252 FPGIPLHHIFSAAGDDLLD-LIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQ 306 G P+H A + I + + +R + +A ++ S+ + Sbjct: 275 ENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAK 330 >4OAU-C nrPDB Length = 699 Score = 68.7 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 29/153 (18%), Positives = 58/153 (37%), Gaps = 21/153 (13%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 ++Y+ D +Y + Q VA+K + A RE+ LQ Sbjct: 347 EKYKIADT----SEGGIYLGFYE--KQEVAVKTF---------CEGSPRAQREVSCLQSS 391 Query: 70 S-HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSH----IKAYMLMTLQG 124 + +++ + H+ ++ + E LE + + + + + + Sbjct: 392 RENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKA 451 Query: 125 LEYLH-QHWILHRDLKPNNLLLDENGVLKLADF 156 ++ LH H+DL+P N+L+D LADF Sbjct: 452 VQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >6EAS-A nrPDB Length = 308 Score = 67.2 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 37/293 (12%), Positives = 89/293 (30%), Gaps = 37/293 (12%) Query: 3 LDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALRE 62 ++++ + + + +G +YK ++ +A+ + + ++ Sbjct: 35 SELETACEDFSNI--IGSTSTCMLYKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKK 91 Query: 63 IKLLQELSHPNIIGLLDAFGHKSNI--SLVFDFMETD--LEVIIKDNSLVLTPSHIKAYM 118 I L ++SH N + LL + +VF++ E + + L Sbjct: 92 ITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRIS 151 Query: 119 LMTLQGLEYLHQHWI--LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTR 176 + LE++HQ R+ + L ++ K++D F + + + Sbjct: 152 MGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDL----EFWNDAKGHNSTTNNE 207 Query: 177 WYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQ 236 +P++ R Y G +L E+L D E Sbjct: 208 LAFSPDMEDIVRKY---------GMVLLEILTGRVPSSEDD--------------GPLEN 244 Query: 237 WPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 W + + + L ++++ +P R + Sbjct: 245 WVSRY-FEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >6EWX-A nrPDB Length = 484 Score = 66.1 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 45/260 (17%), Positives = 76/260 (29%), Gaps = 72/260 (27%) Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG--------------------- 149 + +L GLE+L +H I+HRDL NLLL Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 150 --------------------VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 L +++F L Q ++ APE++ ++ Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNF-LKAKQKPGGTTNLQQKKSQARLAPEIVSASQY 327 Query: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249 D + G ++ ELL + P + DY Sbjct: 328 --RKFDEFQTGILIYELLHQ----------------------PNPFEVRAQLRERDY-RR 362 Query: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPR 309 + P +P ++S L L L +P RI +A + + + Sbjct: 363 EDLPPLPTLSLYSPGLQQLAHL---LLEADPIKRIRIGEAKR--VLQCLLWGPRRELVEQ 417 Query: 310 PNCPVETLKEQSNPALAIKR 329 P E L + + +KR Sbjct: 418 PCPSEEVLCNTLHNWIDMKR 437 >5DMZ-A nrPDB Length = 365 Score = 64.9 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 98/285 (34%), Gaps = 43/285 (15%) Query: 17 FLGEGQFATVYKAR-----DKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 LGEG FA VY+A D Q +K K + E T L E +L + H Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWE---FYIGTQLME-RLKPSMQH 127 Query: 72 PNIIGLLDAFGHKSNISLVFDFMETD-----LEVIIKDNSLVLTPSHIKAYMLMTLQGLE 126 + A ++ LV + + + V+ + ++ + L +E Sbjct: 128 MF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIE 186 Query: 127 YLHQHWILHRDLKPNNLLLDENGV-----------LKLADFGLAKSFG--SPNRAYTHQV 173 +H I+H D+KP+N +L + L L D G + +T + Sbjct: 187 QVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKC 246 Query: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT 233 T ++ E+L + + +D + V + +L ++ ++ + P Sbjct: 247 ETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFGT-YMKVKNEGGECKPEGLFRRLPH 304 Query: 234 EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLF 278 + W + F IP H + LDL++ Sbjct: 305 LDMWNEF--------FHVMLNIPDCHHLPS-----LDLLRQKLKK 336 >5GZ9-A nrPDB Length = 305 Score = 62.6 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 36/214 (16%), Positives = 71/214 (33%), Gaps = 41/214 (19%) Query: 13 EKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHP 72 +L +GEG V+ + K VA+ ++ + + L +++L+ L Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVALSRL-------TRLEMKEDFLHGLQMLKSLQSE 87 Query: 73 NIIGLLDAFGHKSNISLVFDFME-TDLEVI-----IKDNSLVLTPSHIKAYMLMTLQGLE 126 +++ L+ ++ ++ L + + V T H + + + Sbjct: 88 HVVTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIIN 145 Query: 127 YLHQHWILHRDLKPNN--------LLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW- 177 YLH + R + +N LL N + D A + + R Sbjct: 146 YLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCGHREL 204 Query: 178 ---YRAPELL--FGARM---------YGVGVDMW 197 + APE L +G Y VD+W Sbjct: 205 HGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6M7Z-A nrPDB Length = 319 Score = 61.0 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 66/230 (28%), Gaps = 53/230 (23%) Query: 90 VFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENG 149 +F + L + + + ++ + L+ LH +LHR ++ N+ + +G Sbjct: 124 IFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDG 181 Query: 150 VLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL--------LFGARMYGVGVDMWAVGC 201 + L A G+ R + APE+ + V D++++G Sbjct: 182 TVVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLADLALTQGRHTVKSDVYSLGV 239 Query: 202 ILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIF 261 + + LG G Sbjct: 240 -------------------AFRNLVQLLGNGNL-------------------GPEDRGAV 261 Query: 262 SAAGDDLLD-LIQGLFLFNPCARITATQALKMKYFS--NRPGPTPGCQLP 308 +LLD L Q + P R T + +K F N G P Sbjct: 262 RQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARP 311 >6BHC-A nrPDB Length = 438 Score = 61.0 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 90/299 (30%), Gaps = 85/299 (28%) Query: 38 VAIKKIKLGHRSEAKDGINRTALRE-----IKLLQELSH-----PNIIGLLDAFG----H 83 A+K K + E++ + A+R+ + Q+ H PN LL Sbjct: 86 YAVKICKSKAK-ESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQ 142 Query: 84 KSNISLVF---------DFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 +S++ ++ DF+ L S L + +L GLE+L + + Sbjct: 143 RSHVVVITREVPCLTVADFVRDSLAQH--GKSPDLYERQVCLLLLQLCSGLEHLKPYHVT 200 Query: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWY---------------- 178 H DL+ NLLL G A+ FG T TR Sbjct: 201 HCDLRLENLLLVHYQPG-----GTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDP 255 Query: 179 --------RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230 APE++ + D + G ++ E+L + +L Sbjct: 256 EILRDQSRLAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPEL----------- 302 Query: 231 TPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQA 289 T P IP S L L L NP RI + A Sbjct: 303 ------------KEREYTRADLPRIPFR---SPYSRGLQQLASCLLNPNPSERILISDA 346 >5GZA-A nrPDB Length = 290 Score = 61.0 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 36/229 (15%), Positives = 71/229 (31%), Gaps = 57/229 (24%) Query: 4 DVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREI 63 +++S +R + +G+G VY + + Q VA+ + + D L + Sbjct: 22 EIRSGVRR---VKLIGQGAVKKVYLSEWQ--GQKVALSVL-------SSDQYADDFLHGL 69 Query: 64 KLLQELSHPNIIGLLDAFGHKSNISLVFDFMETD----LEVIIKDNSLVL--TPSHIKAY 117 +L+ L +++ L+ + V ++ L+ + + Sbjct: 70 SMLRALQSSHVVTLVGVCEEDA--VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQL 127 Query: 118 MLMTLQGLEYLHQH--WI--------LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNR 167 + + L YLH I LH+ L + LL + L LA + Sbjct: 128 AIDYVAFLAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPE 179 Query: 168 AYTHQVVTR--------WYRAPELL-----------FGARMYGVGVDMW 197 + + + APE L Y D+W Sbjct: 180 VEKGGLGVKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >2JII-A nrPDB Length = 352 Score = 58.3 bits (140), Expect = 4e-09, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 64/178 (35%), Gaps = 13/178 (7%) Query: 81 FGHKSNISLVFDFMETDLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLK 139 LV + L+ + VL+ + L LE+LH++ +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVT 186 Query: 140 PNNLLLD--ENGVLKLADFGLAKSFGSPNRAYTHQVVTR-------WYRAPELLFGARMY 190 N+ +D + + LA +G A + + + +R + + +L G Sbjct: 187 AENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP- 245 Query: 191 GVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT 248 D+ ++G + + L FLP + L I + ++ P + ++ Sbjct: 246 SRRSDLQSLGYCMLKWLYG--FLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIR 301 >4AZW-A nrPDB Length = 471 Score = 54.5 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 40/113 (35%), Gaps = 10/113 (8%) Query: 49 SEAKDGINRTALREIKLLQE----LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKD 104 +E EIK L + P ++ + + LV + + L + Sbjct: 278 AEESQRNKHELHNEIKFLTQPPAGFDAPAVLA-HG--ENAQSGWLVMEKLPGRLLSDMLA 334 Query: 105 NSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFG 157 + I L+ L L + H D++P N+++D +L DFG Sbjct: 335 AGEEIDREKILG---SLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >4CYJ-A nrPDB Length = 438 Score = 53.7 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 23/152 (15%), Positives = 66/152 (43%), Gaps = 28/152 (18%) Query: 23 FA---TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ---ELSHPNIIG 76 F VYKA++ + A+++++ + K +N +++ ++ + +I+ Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILN--------VMKDWKKIKNASIVT 116 Query: 77 LLDAFGHK--SNISLVFDFMETDLEVIIKDNSLV------------LTPSHIKAYMLMTL 122 + + F + + SL+F + L ++++ + + I Y+ Sbjct: 117 IHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIA 176 Query: 123 QGLEYLHQHWILHRDLKPNNLLLDENGVLKLA 154 L+ +H + + R L+P+ ++L + ++L+ Sbjct: 177 NALKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >4AZV-A nrPDB Length = 569 Score = 53.3 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 28/70 (40%), Gaps = 3/70 (4%) Query: 88 SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE 147 LV + + L + + I L+ L L + H D++P N+++D Sbjct: 318 WLVMEKLPGRLLSDMLAAGEEIDREKILG---SLLRSLAALEKQGFWHDDVRPWNVMVDA 374 Query: 148 NGVLKLADFG 157 +L DFG Sbjct: 375 RQHARLIDFG 384 >3ENH-A nrPDB Length = 540 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 38/167 (22%), Positives = 67/167 (40%), Gaps = 27/167 (16%) Query: 17 FLGEGQFATVYKARDKNTNQIVAIK-KIKLGHRSEAKDGINRTAL--REIKLLQELSH-- 71 +G+G A + RD + V IK ++K G+R E D R + RE + L + Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 72 ---PNIIGLLDAFGHKSNISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 P I D ++ ++ L + +I+DN + + Sbjct: 401 IPAPYI---FDVDLDNKR--IMMSYINGKLAKDVIEDN---------LDIAYKIGEIVGK 446 Query: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVV 174 LH++ ++H DL +N + D++ L + DFGL K +V Sbjct: 447 LHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKAVDLIV 491 >5VE6-A nrPDB Length = 492 Score = 51.0 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 20/35 (57%) Query: 111 PSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLL 145 + +L GLE+L +H I+HRDL NLLL Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 42.2 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 47/151 (31%), Gaps = 30/151 (19%) Query: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238 APE++ ++ D + G ++ ELL + P + Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQ----------------------PNPFEVR 360 Query: 239 DMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298 DY + P +P ++S L L L +P RI +A + Sbjct: 361 AQLRERDY-RQEDLPPLPALSLYSPGLQQLAHL---LLEADPIKRIRIGEAKR--VLQCL 414 Query: 299 PGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 + +P E L + + +KR Sbjct: 415 LWGPRRELVQQPGTSEEALCGTLHNWIDMKR 445 >6G38-A nrPDB Length = 357 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 59/178 (33%), Gaps = 46/178 (25%) Query: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR---EIKL 65 ++ ++ + +GEG F V+ + + VAIK I + +T EI + Sbjct: 40 TEKLQRCEKIGEGVFGEVF--QTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 66 LQE-----------------LSHPNIIG------LLDAFGH----------------KSN 86 +E L+ + + LL A+ H Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQ 157 Query: 87 ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH-QHWILHRDLKPNNL 143 + +V +F ++ + + + + + + K+ + L HRDL N+ Sbjct: 158 LFIVLEFEFGGID-LEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4BWP-A nrPDB Length = 448 Score = 47.9 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 21/142 (14%), Positives = 49/142 (34%), Gaps = 41/142 (28%) Query: 27 YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK-- 84 Y+A T +++I K + +++ ++L H N++ L + F K Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTK------CMTLVEMWKKLQHTNVVQLREVFTTKAF 120 Query: 85 --SNISLVFDFMETDLEVIIK-------------------------------DNSLVLTP 111 +++ LV+D+ ++ K N +L Sbjct: 121 GDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPE 180 Query: 112 SHIKAYMLMTLQGLEYLHQHWI 133 + I + ++ GL+ +H + Sbjct: 181 ATIWSIIMQLTAGLKAIHHAGL 202 >3Q60-A nrPDB Length = 371 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 55/329 (16%), Positives = 103/329 (31%), Gaps = 57/329 (17%) Query: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLG---HRSEAKDGINRTAL------ 60 ++ + ++ L G + V+ RD + A+K +G RSE + T Sbjct: 62 RKLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAAARLLG 121 Query: 61 ---REIKLLQEL----------SHPNIIGL---LDAFGHKSNISLVFDFMETDLEVIIKD 104 E + + L S P L D + + + L+ DLE++ Sbjct: 122 ESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYL-LLMPAASVDLELLFST 180 Query: 105 NSLVL----TPSHIKAYML--MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGL 158 V + ++L ++ L ++H P+NL + +G L L D + Sbjct: 181 LDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--V 238 Query: 159 AKSFGSPNRAYTHQVVTRWYRAP-ELLFGAR-MYGVGVDMWAVGCILAELLLRVPFLPGD 216 + + R V + AP E L + + ++ W +G + + Sbjct: 239 SALWKVGTRGPASSVPVTY--APREFLNASTATFTHALNAWQLGLSIYRVWCLFLPF--- 293 Query: 217 SDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLF 276 L TP + SL T G + D + LI Sbjct: 294 -----------GLVTPGIKGSWKRPSLRVPGTDSLAFGS-----CTPLPDFVKTLIGRFL 337 Query: 277 LFNPCARITATQALKMKYFSNRPGPTPGC 305 F+ R+ +A++ F Sbjct: 338 NFDRRRRLLPLEAMETPEFLQLQNEISSS 366 >4WWA-A nrPDB Length = 261 Score = 46.4 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 32/153 (20%), Positives = 56/153 (36%), Gaps = 26/153 (16%) Query: 27 YKARDKNTNQIVAIKK---IKLGHRSEAKDGINRTALREIKLLQELSHPNII------GL 77 Y R K+++Q IK + H + L E +LL +L +I L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKL---YLIPGLCVPQL 94 Query: 78 LDAFGHKSNISLVFDFMETDL---------EVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128 + + I L +F+ DL + + + + + + + L Sbjct: 95 IACDPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLL 152 Query: 129 HQHWILHRDLKPNNLLLDENG---VLKLADFGL 158 H + H DL +N++L +G L DFGL Sbjct: 153 HWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >6R5K-O nrPDB Length = 689 Score = 45.6 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 46/117 (39%), Gaps = 12/117 (10%) Query: 25 TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK 84 T++K + +K++ +S + I++ ++ +++ N+I D F Sbjct: 309 TLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIY----QIWSKINCTNLIKFRDIFQTT 364 Query: 85 S----NISLVFDFMETDL----EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +I LVFD+ L + +T +++ Y++ + +H + Sbjct: 365 KFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 421 >4XR7-L nrPDB Length = 465 Score = 44.9 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 46/117 (39%), Gaps = 12/117 (10%) Query: 25 TVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHK 84 T++K + +K++ +S + I++ ++ +++ N+I D F Sbjct: 85 TLFKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIY----QIWSKINCTNLIKFRDIFQTT 140 Query: 85 S----NISLVFDFMETDL----EVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 +I LVFD+ L + +T +++ Y++ + +H + Sbjct: 141 KFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 197 >4CZY-B nrPDB Length = 429 Score = 44.1 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 26/143 (18%), Positives = 60/143 (41%), Gaps = 21/143 (14%) Query: 27 YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGH--- 83 YKA++ + A+++I+ + K +N T +++ + NI+ + +AF Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEW-----KKIINANIVTVHEAFTTEFF 115 Query: 84 -KSNISLVFDFMETDLEVIIKD-----------NSLVLTPSHIKAYMLMTLQGLEYLHQH 131 S++ V+DF + N+ + + + +Y+ L +H Sbjct: 116 GDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNA 175 Query: 132 WILHRDLKPNNLLLDENGVLKLA 154 + R L+ + + + EN ++LA Sbjct: 176 KLAARCLELSKI-IWENNRIRLA 197 >3DZO-A nrPDB Length = 413 Score = 42.9 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 48/349 (13%), Positives = 102/349 (29%), Gaps = 91/349 (26%) Query: 28 KARDKNTNQIV--------------AIKKIKLGHRSEAKDGINRTALREIKLLQELS-HP 72 +A D+ T + AIK++K ++ + LR IK ++ H Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMK-------EEVLRLRLLRGIKNQKQAKVHL 148 Query: 73 NII------------GLLDAFGHKSNISLV-----FDFMETDLEVI------IKDNSLVL 109 I ++ + ++ ++ + M+++L+ L Sbjct: 149 RFIFPFDLVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSL 208 Query: 110 TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAY 169 L ++ L LH + ++H L+P +++LD+ G + L F + + Sbjct: 209 VHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGASA 265 Query: 170 THQVVTRWYRAPE-----LLFGARMY----GVGVDMWAVGCILAELLLRVPFLPGDSDLD 220 + R + PE +L + + D W +G + Sbjct: 266 VSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIY---------------- 308 Query: 221 QLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNP 280 W LP+ + + L++G + Sbjct: 309 ----------------WIWCADLPNTDDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPK 352 Query: 281 CARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKR 329 R+ QA++ + LP E +E P + Sbjct: 353 EDRLLPLQAMETPEYEQLR-TELSAALPLYQTDGEPTREGGAPPSGTSQ 400 >3BYV-A nrPDB Length = 377 Score = 42.9 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 34/239 (14%), Positives = 75/239 (31%), Gaps = 57/239 (23%) Query: 76 GLLDAFGHKSNISLV-----FDFMETDLEVI------IKDNSLVLTPSHIKAYMLMTLQG 124 ++ + ++ ++ + M+++L+ L L ++ Sbjct: 159 KMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRL 218 Query: 125 LEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL- 183 L LH + ++H L+P +++LD+ G + L F + V +R + PEL Sbjct: 219 LASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGARVVSSV-SRGFEPPELE 274 Query: 184 -----LFGARM----YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTE 234 + R D WA+G ++ + + D+ L IF + Sbjct: 275 ARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIFRSC----- 329 Query: 235 EQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293 + L++G + R+ QA++ Sbjct: 330 ---------------------------KNIPQPVRALLEGFLRYPKEDRLLPLQAMETP 361 >2W1Z-A nrPDB Length = 368 Score = 42.6 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 57/201 (28%), Gaps = 37/201 (18%) Query: 96 TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLAD 155 D+ + L L ++ L + ++H D + N+LLD+ G + L Sbjct: 175 GDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTG 234 Query: 156 F-----GLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV 210 F A + R + T P + D W +G + + Sbjct: 235 FEHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCAD 294 Query: 211 PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 D++L + I+ + Sbjct: 295 LPNTEDAELGGIEWIYRRC--------------------------------KNIPQPVRA 322 Query: 271 LIQGLFLFNPCARITATQALK 291 L++G ++ R+ QA++ Sbjct: 323 LLEGFLRYSKEDRLLPLQAME 343 >1TQM-A nrPDB Length = 282 Score = 41.8 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 33/166 (19%), Positives = 64/166 (38%), Gaps = 26/166 (15%) Query: 14 KLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-------------AL 60 +GEG+ + V+ + + V +K K+GH S K R A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 61 REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM 120 E + LQ+L + + G+ ++ + ++ ++ V P + +L Sbjct: 153 NEFRALQKLQGLAVPKVYAWEGNA----VLMELIDAKELYRVR----VENPDEVLDMILE 204 Query: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPN 166 + ++ H I+H DL N+L+ E G + + DF + G Sbjct: 205 EVA--KFYH-RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEEG 246 >5YK0-A nrPDB Length = 452 Score = 39.1 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 55/178 (30%), Gaps = 56/178 (31%) Query: 24 ATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-------------- 69 V+KA + + VA+K I+ EA +T R + +L++L Sbjct: 146 GQVHKAIW-SDGREVAVK-IQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELV 203 Query: 70 ------------------------SHP-----NIIGLLDAFGHKSNISLVFDFMETDLEV 100 HP +++ + ++ +++E Sbjct: 204 ERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVA-------SAPKVVIQEWIEGVPMA 256 Query: 101 IIKDNSLVLTPSHIKAYMLMT-LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFG 157 I + I + L ++H D P N +L +G + + DFG Sbjct: 257 EIIRHGTTEQRDLIGTLLAELTFDAPRRL---GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6FAI-l nrPDB Length = 425 Score = 39.1 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 36/194 (18%), Positives = 69/194 (35%), Gaps = 36/194 (18%) Query: 3 LDVKSRAKR---YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTA 59 L +K+ R Y + +G G+ + +YK DKN N V +K +LG S NR Sbjct: 83 LALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDY 141 Query: 60 L------------------REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVI 101 L +E + + L + + F + +I +V + +E Sbjct: 142 LKKSNQGANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRR 199 Query: 102 IKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE------NGVLKLAD 155 ++ + + P M + L ++H D N+++ + + + D Sbjct: 200 LRKHKNI--PKLYSDLMCFIVD----LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVID 253 Query: 156 FGLAKSFGSPNRAY 169 F S + Y Sbjct: 254 FPQCISIQHQDADY 267 >6G18-v nrPDB Length = 552 Score = 36.4 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 32/74 (43%), Gaps = 6/74 (8%) Query: 83 HKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNN 142 + ++V + + + + + + S M + ++ L H ++H D N Sbjct: 180 DYNRHAVVMELING--YPLCQIHHVEDPASVYDEAMELIVK----LANHGLIHGDFNEFN 233 Query: 143 LLLDENGVLKLADF 156 L+LDE+ + + DF Sbjct: 234 LILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 35.2 bits (80), Expect = 0.037, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 32/74 (43%), Gaps = 6/74 (8%) Query: 83 HKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNN 142 + ++V + + + + + + S M + ++ L H ++H D N Sbjct: 180 DYNRHAVVMELING--YPLCQIHHVEDPASVYDEAMELIVK----LANHGLIHGDFNEFN 233 Query: 143 LLLDENGVLKLADF 156 L+LDE+ + + DF Sbjct: 234 LILDESDHITMIDF 247 >6G5I-z nrPDB Length = 568 Score = 33.3 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 33/79 (41%), Gaps = 2/79 (2%) Query: 89 LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ-HWILHRDLKPNNLLLDE 147 LV F+ D ++ L+ S + L +Q + ++Q ++H DL N+L Sbjct: 275 LVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-H 333 Query: 148 NGVLKLADFGLAKSFGSPN 166 G + + D + P+ Sbjct: 334 GGGVYIIDVSQSVEHDHPH 352 >6H8S-A nrPDB Length = 301 Score = 33.3 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 17/42 (40%) Query: 282 ARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNP 323 R T + LK +F++ P + P V ++E + Sbjct: 181 RRGTEERTLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQ 222 >4OTP-A nrPDB Length = 352 Score = 33.3 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 33/79 (41%), Gaps = 2/79 (2%) Query: 89 LVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ-HWILHRDLKPNNLLLDE 147 LV F+ D ++ L+ S + L +Q + ++Q ++H DL N+L Sbjct: 133 LVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-H 191 Query: 148 NGVLKLADFGLAKSFGSPN 166 G + + D + P+ Sbjct: 192 GGGVYIIDVSQSVEHDHPH 210 >6DFL-A nrPDB Length = 259 Score = 31.8 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 42/99 (42%), Gaps = 5/99 (5%) Query: 84 KSNISLVFDFMET--DLEVIIKDNSLVLTPSHI-KAYMLMTLQGLEYLHQHWILHRDLKP 140 + + +V + + DLEV +D P + +A + + + +H+ + HRD Sbjct: 107 RQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYI 166 Query: 141 NNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 + LL + + DF L+ +RA T + +R Sbjct: 167 CHFLLHTDKPVSADDFRLS--VIDLHRAQTRDATPKRWR 203 >3LV4-A nrPDB Length = 456 Score = 31.8 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 6/41 (14%), Positives = 14/41 (34%) Query: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLT 110 HPN++ F + +V+ + ++ D Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGGIFILEMDKKTGFP 182 >5OVR-A nrPDB Length = 305 Score = 31.8 bits (71), Expect = 0.49, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 16/39 (41%) Query: 285 TATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNP 323 T + LK +F++ P + P V ++E + Sbjct: 188 TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQ 226 >4ESA-B nrPDB Length = 146 Score = 31.8 bits (71), Expect = 0.52, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 19/50 (38%), Gaps = 3/50 (6%) Query: 21 GQFATVYKARDKNTNQIVA---IKKIKLGHRSEAKDGINRTALREIKLLQ 67 G F +Y A NQ VA IK + R+ + E+ +L Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILH 92 >2X8T-A nrPDB Length = 471 Score = 31.0 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 5/22 (22%), Positives = 10/22 (45%) Query: 70 SHPNIIGLLDAFGHKSNISLVF 91 HPN++ F + +V+ Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVY 186 >4GYG-A nrPDB Length = 397 Score = 31.0 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 57/190 (30%), Gaps = 46/190 (24%) Query: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR---------- 61 Y +G G+ + + D+ Q V +K +LG S NR LR Sbjct: 97 YSVGSRIGVGKESDIMIVADEKGKQKV-LKIHRLGRISFRTVKANRDYLRNRSTGSWMYL 155 Query: 62 -------EIKLLQELSHPNIIGLLDAFGHKSNIS-----LVFDFMETDLEVIIKDNSLVL 109 E ++ L + F I+ +V L + + Sbjct: 156 SRLAAIKEFAFMKAL-------YEEGFPVPEPIAQSRHTIVM-----SLVDALPMRQVSS 203 Query: 110 TPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLK----------LADFGLA 159 P Y + L L +H ++H D N+L+ E + + DF Sbjct: 204 VPDPASLYADLIALILR-LAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDFPQM 262 Query: 160 KSFGSPNRAY 169 S PN Sbjct: 263 VSMDHPNAEM 272 >6GL3-A nrPDB Length = 386 Score = 31.0 bits (69), Expect = 0.85, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 69/185 (37%), Gaps = 30/185 (16%) Query: 98 LEVIIKDNSLVLTPS--HIKAYMLMTLQG---LEYLHQHWILHRDLKPNNLLLDENGVLK 152 L+ ++++ T + + + + G + YL Q H N+LLD G + Sbjct: 219 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 274 Query: 153 LADFG--LAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV 210 DFG L+ S + + +T + +++ G DM+ ++L+ Sbjct: 275 HIDFGFILSSSPRNLGFETSAFKLTTEFV--DVMGGLDG-----DMFNY----YKMLMLQ 323 Query: 211 PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 + +D++ +I E + ++ LP + + + S + L Sbjct: 324 GLIAARKHMDKVVQIVEIMQQGSQ--------LPCFHGSSTIRNLKERFHMSMTEEQLQL 375 Query: 271 LIQGL 275 L++ + Sbjct: 376 LVEQM 380 >4D0L-A nrPDB Length = 566 Score = 30.6 bits (68), Expect = 0.94, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 69/185 (37%), Gaps = 30/185 (16%) Query: 98 LEVIIKDNSLVLTPS--HIKAYMLMTLQG---LEYLHQHWILHRDLKPNNLLLDENGVLK 152 L+ ++++ T + + + + G + YL Q H N+LLD G + Sbjct: 398 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 453 Query: 153 LADFG--LAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV 210 DFG L+ S + + +T + +++ G DM+ ++L+ Sbjct: 454 HIDFGFILSSSPRNLGFETSAFKLTTEFV--DVMGGLDG-----DMFNY----YKMLMLQ 502 Query: 211 PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 + +D++ +I E + ++ LP + + + S + L Sbjct: 503 GLIAARKHMDKVVQIVEIMQQGSQ--------LPCFHGSSTIRNLKERFHMSMTEEQLQL 554 Query: 271 LIQGL 275 L++ + Sbjct: 555 LVEQM 559 >5C4G-E nrPDB Length = 529 Score = 30.6 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 69/185 (37%), Gaps = 30/185 (16%) Query: 98 LEVIIKDNSLVLTPS--HIKAYMLMTLQG---LEYLHQHWILHRDLKPNNLLLDENGVLK 152 L+ ++++ T + + + + G + YL Q H N+LLD G + Sbjct: 361 LDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGHII 416 Query: 153 LADFG--LAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRV 210 DFG L+ S + + +T + +++ G DM+ ++L+ Sbjct: 417 HIDFGFILSSSPRNLGFETSAFKLTTEFV--DVMGGLDG-----DMFNY----YKMLMLQ 465 Query: 211 PFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLD 270 + +D++ +I E + ++ LP + + + S + L Sbjct: 466 GLIAARKHMDKVVQIVEIMQQGSQ--------LPCFHGSSTIRNLKERFHMSMTEEQLQL 517 Query: 271 LIQGL 275 L++ + Sbjct: 518 LVEQM 522 >4BVU-A nrPDB Length = 211 Score = 30.2 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 49/151 (32%), Gaps = 29/151 (19%) Query: 14 KLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 +G+G A +++ + K + EI + Sbjct: 44 LGKLIGQGSTAEIFE-------------DVNDSSALYKKYDLIGNQYNEILEMAWQESE- 89 Query: 74 IIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLT-------PSHIKAYMLMTLQGLE 126 L +AF S+V + +++ L+ P +I++ L + L Sbjct: 90 ---LFNAFY-GDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLN 145 Query: 127 YLHQHWILHRDLKPNNLLLDENGV-LKLADF 156 + I+H DL N+L D+ L DF Sbjct: 146 ---ELSIIHYDLNTGNMLYDKESESLFPIDF 173 >6EF6-A nrPDB Length = 354 Score = 30.2 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 132 WILHRDLKPNNLLLDEN---GVLKLADF 156 ++H DL+ NLL+D + + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6G90-D nrPDB Length = 629 Score = 30.2 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 17/104 (16%), Positives = 28/104 (26%), Gaps = 21/104 (20%) Query: 202 ILAELLLRVPFLPG--------DSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFP 253 IL ++L + P L G + L L + L T + + DY+ Sbjct: 76 ILWQILRKYPLLFGFWKRFATIEYQLFGLKKSIAVLATSVKWFPTSLELWCDYLNVLCVN 135 Query: 254 GIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 + DLI Q L ++ Sbjct: 136 NPNETDFIRNNFEIAKDLIGK-------------QFLSHPFWDK 166 >5JY7-I nrPDB Length = 441 Score = 29.8 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 17/39 (43%), Gaps = 5/39 (12%) Query: 64 KLLQELSHPNIIGLLDAFGHKSN-----ISLVFDFMETD 97 ++L +P++ LL +F + + +V +F Sbjct: 162 RVLARAGNPHVARLLGSFETEWEGEPYALGMVTEFAANS 200 >2UZK-A nrPDB Length = 97 Score = 29.1 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 16/41 (39%), Gaps = 5/41 (12%) Query: 270 DLIQGLFLFNPCARITATQALK-----MKYFSNRPGPTPGC 305 DLI +P R+T +Q + + YF ++ Sbjct: 8 DLITRAIESSPDKRLTLSQIYEWMVRCVPYFKDKGDSNSSA 48 >2ICU-A nrPDB Length = 229 Score = 29.1 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 10/47 (21%), Positives = 16/47 (34%), Gaps = 3/47 (6%) Query: 81 FGHKSN---ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 F +V + L I LVL+P + +M + G Sbjct: 143 FERGDEAEGFLIVTAAADQGLVDIHDRRPLVLSPEAAREWMRQEISG 189 >4H05-A nrPDB Length = 273 Score = 28.7 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 15/27 (55%), Gaps = 2/27 (7%) Query: 133 ILHRDLKPNNLLLD-ENGVLK-LADFG 157 + H DL P+N+LLD + L D G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >5LJ3-H nrPDB Length = 591 Score = 28.3 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 16/28 (57%), Gaps = 1/28 (3%) Query: 135 HRDLKPNNLLLDENGVLK-LADFGLAKS 161 HRDL N+L+ + + K + DF L K Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQ 68 >3NPK-A nrPDB Length = 291 Score = 27.9 bits (61), Expect = 6.2, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 13/27 (48%) Query: 112 SHIKAYMLMTLQGLEYLHQHWILHRDL 138 + L LE++H + ++H DL Sbjct: 56 PELLNQALDVALALEFIHTYSLIHDDL 82 >2QY0-A nrPDB Length = 159 Score = 27.5 bits (60), Expect = 7.8, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 25/69 (36%), Gaps = 17/69 (24%) Query: 119 LMTLQGLEYLHQHWIL-------HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH 171 ++G + LH + HR + P K+ D G ++ + + YT Sbjct: 38 YQLIEGNQVLHSFTAVCQDDGTWHRAM-PR---------CKIKDCGQPRNLPNGDFRYTT 87 Query: 172 QVVTRWYRA 180 + Y+A Sbjct: 88 TMGVNTYKA 96 >1GPZ-A nrPDB Length = 399 Score = 27.5 bits (60), Expect = 7.8, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 25/69 (36%), Gaps = 17/69 (24%) Query: 119 LMTLQGLEYLHQHWIL-------HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTH 171 ++G + LH + HR + P K+ D G ++ + + YT Sbjct: 36 YQLIEGNQVLHSFTAVCQDDGTWHRAM-PR---------CKIKDCGQPRNLPNGDFRYTT 85 Query: 172 QVVTRWYRA 180 + Y+A Sbjct: 86 TMGVNTYKA 94 >2R17-C nrPDB Length = 298 Score = 27.5 bits (60), Expect = 8.5, Method: Composition-based stats. Identities = 9/59 (15%), Positives = 19/59 (32%) Query: 202 ILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHI 260 + E+L R + + ++ L E P++ S + L H+ Sbjct: 237 LFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHL 295 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.152 0.469 Lambda K H 0.267 0.0469 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,585,971 Number of Sequences: 36641 Number of extensions: 691217 Number of successful extensions: 5907 Number of sequences better than 10.0: 521 Number of HSP's better than 10.0 without gapping: 954 Number of HSP's successfully gapped in prelim test: 46 Number of HSP's that attempted gapping in prelim test: 1885 Number of HSP's gapped (non-prelim): 1156 length of query: 346 length of database: 10,336,785 effective HSP length: 98 effective length of query: 248 effective length of database: 6,745,967 effective search space: 1672999816 effective search space used: 1672999816 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.5 bits)