BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P50579 (478 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1QZY-A nrPDB 991 0.0 5LYW-A nrPDB 785 0.0 3FMR-A nrPDB 269 2e-72 1XGN-A nrPDB 188 4e-48 2Q8K-A nrPDB 103 2e-22 2V6C-A nrPDB 101 6e-22 3TB5-A nrPDB 74 1e-13 4KM3-A nrPDB 56 3e-08 3S6B-A nrPDB 49 3e-06 1O0X-A nrPDB 46 3e-05 4IPA-A nrPDB 46 3e-05 1QXW-A nrPDB 44 1e-04 3MR1-A nrPDB 44 2e-04 3Q6D-A nrPDB 41 0.001 4FO7-A nrPDB 41 0.001 4FUK-A nrPDB 37 0.024 6MRF-A nrPDB 32 0.60 3S1S-A nrPDB 32 0.83 5C3C-A nrPDB 31 1.5 3NA8-A nrPDB 30 2.0 3OHM-B nrPDB 28 7.2 3H2Z-A nrPDB 28 7.6 6DEB-A nrPDB 28 8.2 >1QZY-A nrPDB Length = 478 Score = 991 bits (2562), Expect = 0.0, Method: Compositional matrix adjust. Identities = 477/478 (99%), Positives = 478/478 (100%) Query: 1 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES 60 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES Sbjct: 1 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES 60 Query: 61 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI 120 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI Sbjct: 61 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI 120 Query: 121 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 180 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR Sbjct: 121 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 180 Query: 181 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 240 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT Sbjct: 181 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 240 Query: 241 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 300 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV Sbjct: 241 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 300 Query: 301 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 360 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPI+KGGEATRMEEGEV Sbjct: 301 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIIKGGEATRMEEGEV 360 Query: 361 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 420 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL Sbjct: 361 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 420 Query: 421 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 478 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY Sbjct: 421 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 478 >5LYW-A nrPDB Length = 378 Score = 785 bits (2028), Expect = 0.0, Method: Compositional matrix adjust. Identities = 371/371 (100%), Positives = 371/371 (100%) Query: 108 GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWN 167 GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWN Sbjct: 2 GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWN 61 Query: 168 DFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNN 227 DFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNN Sbjct: 62 DFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNN 121 Query: 228 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTG 287 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTG Sbjct: 122 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTG 181 Query: 288 IKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIV 347 IKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIV Sbjct: 182 IKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIV 241 Query: 348 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN 407 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN Sbjct: 242 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN 301 Query: 408 ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPT 467 ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPT Sbjct: 302 ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPT 361 Query: 468 CKEVVSRGDDY 478 CKEVVSRGDDY Sbjct: 362 CKEVVSRGDDY 372 >3FMR-A nrPDB Length = 358 Score = 269 bits (688), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 141/302 (46%), Positives = 192/302 (63%), Gaps = 11/302 (3%) Query: 183 VMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDT-TV 241 V S ++PG+T++EI +ED +R L+K N G+ FP G S+N+CAAHYT N G+ V Sbjct: 62 VQSIVRPGITLLEIVRSIEDSTRTLLKGER-NNGIGFPAGMSMNSCAAHYTVNPGEQDIV 120 Query: 242 LQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVG 301 L+ DD+ KIDFGTH GRI+D AFTV F + LL A ++ T TGIK G+DVR+CD+G Sbjct: 121 LKEDDVLKIDFGTHSDGRIMDSAFTVAFKENLEPLLVAAREGTETGIKSLGVDVRVCDIG 180 Query: 302 EAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVY 361 I EV+ SYEVEI G+ + ++PI +L+GHSI Q+RIH G ++P V + TR++ Y Sbjct: 181 RDINEVISSYEVEIGGRMWPIRPISDLHGHSISQFRIHGGISIPAVNNRDTTRIKGDSFY 240 Query: 362 AIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNV---INENFGTLAFCRR 418 A+ETF +TGKG + D CSH++ N R K L+ V + ++ GTL F R Sbjct: 241 AVETFATTGKGSIDDRPPCSHFVLN----TYKSRKLFNKDLIKVYEFVKDSLGTLPFSPR 296 Query: 419 WLDRLGESK--YLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGD 476 LD G K L ++ L +G++ PYPPL DI G AQFEHT+ L KEV++RGD Sbjct: 297 HLDYYGLVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEVLTRGD 356 Query: 477 DY 478 DY Sbjct: 357 DY 358 >1XGN-A nrPDB Length = 295 Score = 188 bits (478), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 115/298 (38%), Positives = 166/298 (55%), Gaps = 20/298 (6%) Query: 169 FREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNC 228 +A E ++VR+ + +PGM ++E+ E +E K+I E L AFP S+N Sbjct: 6 LMKAGEIAKKVREKAIKLARPGMLLLELAESIE----KMIME--LGGKPAFPVNLSINEI 59 Query: 229 AAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGI 288 AAHYTP GDTTVL+ D KID G HI G I D A TV + D L++A K+A N I Sbjct: 60 AAHYTPYKGDTTVLKEGDYLKIDVGVHIDGFIADTAVTVRVGMEEDELMEAAKEALNAAI 119 Query: 289 KCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVP-IV 347 A V + ++G+AI+ EI + + KPI NL+GH I +Y++HAG ++P I Sbjct: 120 SVARAGVEIKELGKAIEN-------EIRKRGF--KPIVNLSGHKIERYKLHAGISIPNIY 170 Query: 348 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN 407 + + ++EG+V+AIE F + G G V + YM D VP+R+ + + LL I Sbjct: 171 RPHDNYVLKEGDVFAIEPFATIGAGQVIEVPPTLIYMYVRD---VPVRVAQARFLLAKIK 227 Query: 408 ENFGTLAFCRRWLDR-LGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILL 464 +GTL F RWL + E + +ALK L G + YP L +I+ AQFEHTI++ Sbjct: 228 REYGTLPFAYRWLQNDMPEGQLKLALKTLEKAGAIYGYPVLKEIRNGIVAQFEHTIIV 285 >2Q8K-A nrPDB Length = 401 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 74/283 (26%), Positives = 123/283 (43%), Gaps = 17/283 (6%) Query: 197 CEK-----LEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDT-TVLQYDDICKI 250 CEK +E+ + KE + G+AFPT S+NNC H++P D +L+ D+ KI Sbjct: 56 CEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKI 115 Query: 251 DFGTHISGRIIDCAFTVTFNPKYDTLLKAVK-DATNTGIKCAGIDVRLCDVGEAIQEVME 309 D G H+ G I + A T + T + K D CA +RL G +V E Sbjct: 116 DLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTE 175 Query: 310 SYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTV------PIVKGGEATRMEEGEVYAI 363 ++ ++ PI + H + Q+ I KT+ K E E EVYA+ Sbjct: 176 AWNKV--AHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAV 233 Query: 364 ETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRL 423 + S+G+G D + + K +++ ++ + + F + F R + Sbjct: 234 DVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFE-- 291 Query: 424 GESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRP 466 E K M + ++ P+ L + +G + AQF+ T+LL P Sbjct: 292 DEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMP 334 >2V6C-A nrPDB Length = 353 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 74/283 (26%), Positives = 122/283 (43%), Gaps = 17/283 (6%) Query: 197 CEK-----LEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDT-TVLQYDDICKI 250 CEK +E+ + KE + G+AFPT S+NNC H++P D +L+ D+ KI Sbjct: 42 CEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKI 101 Query: 251 DFGTHISGRIIDCAFTVTFNPKYDTLLKAVK-DATNTGIKCAGIDVRLCDVGEAIQEVME 309 D G H+ G I + A T T + K D CA +RL G +V E Sbjct: 102 DLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTE 161 Query: 310 SYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTV------PIVKGGEATRMEEGEVYAI 363 ++ ++ PI + H + Q+ I KT+ K E E EVYA+ Sbjct: 162 AWNKV--AHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAV 219 Query: 364 ETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRL 423 + S+G+G D + + K +++ ++ + + F + F R + Sbjct: 220 DVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFALRAFE-- 277 Query: 424 GESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRP 466 E K M + ++ P+ L + +G + AQF+ T+LL P Sbjct: 278 DEKKARMGVVECAKHELLQPFNVLYEREGEFVAQFKFTVLLMP 320 >3TB5-A nrPDB Length = 264 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/210 (30%), Positives = 100/210 (47%), Gaps = 27/210 (12%) Query: 171 EAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNA------GLAFPTGCS 224 E+ E V +++ ++IKPG+T +I E R I+ +G A G + T CS Sbjct: 15 ESGELLADVHRHLRTFIKPGITSWDI----EVFVRDFIESHGGVAAQIGYEGYKYATCCS 70 Query: 225 LNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTF---NPKYDTLLKAVK 281 +N+ H P VL+ D+ K+D + G I D ++ P+ D L++ K Sbjct: 71 INDEICHGFPRK---KVLKDGDLIKVDMCVDLKGAISDSCWSYVVGESTPEIDRLMEVTK 127 Query: 282 DATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAG 341 A GI+ A + R+ D+G AIQ +E G+ Y V +R+ GH IG IH Sbjct: 128 KALYLGIEQAQVGNRIGDIGHAIQTYVE-------GEGYGV--VRDFVGHGIGP-TIHES 177 Query: 342 KTVPIV-KGGEATRMEEGEVYAIETFGSTG 370 +P + G+ R++EG V IE +TG Sbjct: 178 PMIPHYGEAGKGLRLKEGMVITIEPMVNTG 207 >4KM3-A nrPDB Length = 286 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 78/274 (28%), Positives = 115/274 (41%), Gaps = 55/274 (20%) Query: 151 TSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICE------KLEDCS 204 ++ E +A+D+A DF A H +R IKPG+ M E+ E K E+ Sbjct: 6 SAREIEAMDKAG-----DF--LASIHIGLRDL----IKPGVDMWEVEEYVRRRCKEENFL 54 Query: 205 RKLIKENGLNAGLAFPTGCSLNNCAAHYTPN---AGDTTVLQYD------------DICK 249 I +G + T CSLN+ AH P D +L+ D ++ K Sbjct: 55 PLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSK 114 Query: 250 IDFGT---------HISGRIIDC--AFTV-TFNPKYDTLLKAVKDATNTGIKCAGIDVRL 297 ++F SG + D A+ V T + + L+ K+A GI+ A + R+ Sbjct: 115 LNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRI 174 Query: 298 CDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVK-GGEATRME 356 D+G AIQE ES + Y V +R+L GH +G +H VP G R+ Sbjct: 175 GDIGAAIQEYAES-------RGYGV--VRDLVGHGVGP-TMHEEPMVPNYGIAGRGLRLR 224 Query: 357 EGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVG 390 EG V IE +TG + DM+ K D G Sbjct: 225 EGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGG 258 >3S6B-A nrPDB Length = 368 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 88/215 (40%), Gaps = 16/215 (7%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGL---A 218 +EE REA R+ Y + + PG+T EI K+ + +IK N + L Sbjct: 105 NEEEIQRIREACILGRKTLDYAHTLVSPGVTTDEIDRKVHEF---IIKNNAYPSTLNYYK 161 Query: 219 FPTGC--SLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTL 276 FP C S+N H P D L+ DI ID G D T F + + Sbjct: 162 FPKSCCTSVNEIVCHGIP---DYRPLKSGDIINIDISVFYKGVHSDLNETY-FVGDINDV 217 Query: 277 LKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQY 336 K K+ T ++ C G + + + + K + V +R+ +GH +G+ Sbjct: 218 PKEGKELVETCYFSLMEAIKKCKPGMFYKNIGTLIDAYVSKKNFSV--VRSYSGHGVGK- 274 Query: 337 RIHAGKTVPIVKGGEAT-RMEEGEVYAIETFGSTG 370 H+ TVP K +A M+ G V+ IE + G Sbjct: 275 LFHSNPTVPHFKKNKAVGIMKPGHVFTIEPMINQG 309 >1O0X-A nrPDB Length = 262 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 88/231 (38%), Gaps = 33/231 (14%) Query: 170 REAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNA--GLAFPTGCSLNN 227 + A A R+VRK ++ PG T ++ + + +KL + G + T S+N Sbjct: 30 KAVAVALREVRKVIV----PGKTAWDVETLVLEIFKKLRVKPAFKGYGGYKYATCVSVNE 85 Query: 228 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTF---NPKYDTLLKAVKDAT 284 H P V + DI +D G G D A T + + L++ ++ Sbjct: 86 EVVHGLPL--KEKVFKEGDIVSVDVGAVYQGLYGDAAVTYIVGETDERGKELVRVTREVL 143 Query: 285 NTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTV 344 IK +RL DV IQE +ES + IR+ GH +G+ +H + Sbjct: 144 EKAIKMIKPGIRLGDVSHCIQETVESVGFNV---------IRDYVGHGVGR-ELHEDPQI 193 Query: 345 PIVKG-GEATRMEEGEVYAIETFGSTG-----------KGVVHDDMECSHY 383 P G + +G AIE S G V D C+H+ Sbjct: 194 PNYGTPGTGVVLRKGMTLAIEPMVSEGDWRVVVKEDGWTAVTVDGSRCAHF 244 >4IPA-A nrPDB Length = 423 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 69/302 (22%), Positives = 115/302 (38%), Gaps = 37/302 (12%) Query: 154 EKKALDQA--SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK----LEDCSRKL 207 EKK D S ++ ++ AA+ +V V PG +I+ICE+ +E+ K+ Sbjct: 12 EKKEADNVAISVDVLTKYKTAAQISEKVLAEVSKLCVPGAKIIDICEQGDKLMEEELSKV 71 Query: 208 IKENGLNAGLAFPTGCSLNNCAAHYTPNAGD----TTVLQYDDICKIDFGTHISGR-IID 262 ++ N G + PT S YTP D T +Q + KI G I G I Sbjct: 72 YRDKKTNKGFSHPTTVSPAAFITPYTPLRSDEKEAATEIQPGEPIKIQLGAQIDGYGTIV 131 Query: 263 CAFTVTFNP---------KYDTLLKA-------VKDATNTGIKCAGID---VRLCDVGEA 303 C V N + D L ++ G+ G D + V Sbjct: 132 CDTIVAKNANDPDVIEGRQADLFLATYYANEVLLRLMVPPGLLATGTDEEKAKAAAVKPP 191 Query: 304 IQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATR----MEEGE 359 Q + S +E K Y I + + I K + I+ GE + E G+ Sbjct: 192 SQAKISSL-LEKVAKAYDCNIIESTTSWLFDKNEIEGKKKI-ILSPGENIKGEGVPEVGD 249 Query: 360 VYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRW 419 V+ +E S G G V + + + + + ++ P ++ + + + + FGT F R Sbjct: 250 VWGVEVGCSLGSGKVKQFEQRATLHRRTNNTYA-LKRPTSRKIYSEVQKKFGTFPFSLRQ 308 Query: 420 LD 421 L+ Sbjct: 309 LE 310 >1QXW-A nrPDB Length = 252 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 94/224 (41%), Gaps = 27/224 (12%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENG-LNAGL--- 217 +EE +E +VR + + KPG+T ++L++ +++L +E G ++A + Sbjct: 5 TEEELQALKEIGYICAKVRNTMQAATKPGIT----TKELDNIAKELFEEYGAISAPIHDE 60 Query: 218 AFP--TGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDT 275 FP T S+N AH P+ V++ D+ ID +G D + D Sbjct: 61 NFPGQTCISVNEEVAHGIPSK---RVIREGDLVNIDVSALKNGYYADTGISFVVGESDDP 117 Query: 276 LLKAVKDATNTGIKCAGIDVR----LCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGH 331 + + V D + A V+ L ++G+A+ + +K I+NL GH Sbjct: 118 MKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNT---------ARQNDLKVIKNLTGH 168 Query: 332 SIGQYRIHA-GKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVV 374 +G A + + T + EG V AIE F S+ V Sbjct: 169 GVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFV 212 >3MR1-A nrPDB Length = 252 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 84/220 (38%), Gaps = 29/220 (13%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLED-CSRKLIKENGLNAGL--- 217 +E+ + R A + + ++ +KP +T L D C + N + A L Sbjct: 10 TEKDFIKMRAAGKLAAETLDFITDHVKPNVT----TNSLNDLCHNFITSHNAIPAPLNYK 65 Query: 218 AFPTGC--SLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFT-----VTFN 270 FP S+N+ H PN L+ DI ID + G D + V Sbjct: 66 GFPKSICTSINHVVCHGIPNDKP---LKNGDIVNIDVTVILDGWYGDTSRMYYVGDVAIK 122 Query: 271 PKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNG 330 PK L++ DA GI+ +L D+G AIQ E + + +R+ G Sbjct: 123 PK--RLIQVTYDAMMKGIEVVRPGAKLGDIGYAIQSYAEKHNYSV---------VRDYTG 171 Query: 331 HSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTG 370 H IG+ + + G ++EG + +E + G Sbjct: 172 HGIGRVFHDKPSILNYGRNGTGLTLKEGMFFTVEPMINAG 211 >3Q6D-A nrPDB Length = 356 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 65/153 (42%), Gaps = 16/153 (10%) Query: 154 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGL 213 EK L + EI +EAA+ ++++S+I+PG++ IE+ +LE R K+ Sbjct: 125 EKLRLIKTDSEI-KILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMR---KQGAT 180 Query: 214 NAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVT----- 268 ++ L + H V++ D +DFG + G D T+ Sbjct: 181 SSSFDIIVASGLRSALPH---GVASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPS 237 Query: 269 --FNPKYDTLLKAVKDATNTGIKCAGIDVRLCD 299 Y+ +L+A N GIK AG+ R D Sbjct: 238 DKLKEIYNIVLEAQLRGVN-GIK-AGLTGREAD 268 >4FO7-A nrPDB Length = 280 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 50/209 (23%), Positives = 79/209 (37%), Gaps = 18/209 (8%) Query: 169 FREAAEAHRQVRKYVMSWIKPGMTMIE---ICEKLEDCSRKLIKENGLNAGLAFPTGCSL 225 R A +V + + IKPG+T E IC +K I G S+ Sbjct: 14 MRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVNEQKAIPAPLNYKGFPKSICTSI 73 Query: 226 NNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCA--FTVTFNPKY-DTLLKAVKD 282 N+ H PN L+ DI +D G D + F V P++ D L + ++ Sbjct: 74 NHVVCHGIPNEKP---LKEGDILNVDITVIKDGYHGDTSKMFLVGKTPEWADRLCQITQE 130 Query: 283 ATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGK 342 GI L D+GE IQ+ E + +R GH IG+ + Sbjct: 131 CMYKGISVVRPGAHLGDIGEIIQKHAEKNGFSV---------VREYCGHGIGKVFHEEPQ 181 Query: 343 TVPIVKGGEATRMEEGEVYAIETFGSTGK 371 + + G ++EG ++ IE + G+ Sbjct: 182 VLHYGRAGTGIELKEGMIFTIEPMINQGR 210 >4FUK-A nrPDB Length = 337 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 83/211 (39%), Gaps = 25/211 (11%) Query: 169 FREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCS-RKLIKENGLNAGLAFPTGC--SL 225 + + R+V + KPG+T E+ + + + + + + LN FP S+ Sbjct: 72 IKTVCQLSREVLDIATAAAKPGITTDELDRIVHEATVERNMYPSPLNY-YGFPKSVCTSV 130 Query: 226 NNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATN 285 N H P D+ L+ DI ID ++++G D TV D ++ V A Sbjct: 131 NEVICHGIP---DSRELEEGDILNIDVSSYLNGFHGDLNETVFIGRPDDDSVRLVHAAYE 187 Query: 286 TGIKCAGIDV-----RLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHA 340 CAGI V VG+AI+ Y+ + +R GH +G + H Sbjct: 188 C--LCAGIGVVKPEALYKQVGDAIEACASQYQCSV---------VRTYTGHGVG-HLFHT 235 Query: 341 GKTVPIVKGGEAT-RMEEGEVYAIETFGSTG 370 TV ++ M G V+ IE + G Sbjct: 236 SPTVCHYANNKSLGMMRPGHVFTIEPMINLG 266 >6MRF-A nrPDB Length = 270 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 35/151 (23%), Positives = 57/151 (37%), Gaps = 15/151 (9%) Query: 224 SLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKY----DTLLKA 279 S+N+ H P+ + +L+ DI ID G D + + L K Sbjct: 83 SVNHVVCHGIPS--ENKILKNGDILNIDVTVIKDGYHGDTNMMYIVGGETSILANRLCKV 140 Query: 280 VKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIH 339 ++A G+ L D+G AIQ+ +ES + +R GH IG Sbjct: 141 AQEAMYRGMATVRDGSYLGDIGHAIQKYVESERFSV---------VREYCGHGIGTVFHD 191 Query: 340 AGKTVPIVKGGEATRMEEGEVYAIETFGSTG 370 + + + G R+E G + IE + G Sbjct: 192 EPQVLHYGQAGTGMRLEAGMTFTIEPMVNAG 222 >3S1S-A nrPDB Length = 878 Score = 31.6 bits (70), Expect = 0.83, Method: Compositional matrix adjust. Identities = 15/47 (31%), Positives = 20/47 (42%) Query: 222 GCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVT 268 G LNNC Y P+ GD V Y IC+ + +D + V Sbjct: 3 GKGLNNCVFSYLPSYGDDEVSVYHPICEAALNQALVNTGLDSTYEVV 49 >5C3C-A nrPDB Length = 281 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 45/101 (44%), Gaps = 16/101 (15%) Query: 262 DCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQ 321 D +++NP Y +L+K +K +T D D I+ + S+E +D T + Sbjct: 157 DFQIVISYNPGYQSLMKDLKQSTKQRFGALDFDYPKPD----IEAEIVSHEAGVDKDTAE 212 Query: 322 -----VKPIRNLNGHSIGQ-----YRIHAGKTVPIVKGGEA 352 + RNL GH + + ++AGK I KG +A Sbjct: 213 KLVQIAQKARNLKGHGLDEGLSTRLLVYAGKL--IAKGVDA 251 >3NA8-A nrPDB Length = 315 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 2/73 (2%) Query: 325 IRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYM 384 I + G++I + G +P + G R+ +G V+AI GSTG+G D E + Sbjct: 25 IHGIIGYTITPFAADGGLDLPAL-GRSIERLIDGGVHAIAPLGSTGEGAYLSDPEWDEVV 83 Query: 385 KNFDVGHVPIRLP 397 +F + V R+P Sbjct: 84 -DFTLKTVAHRVP 95 >3OHM-B nrPDB Length = 885 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 39/85 (45%), Gaps = 8/85 (9%) Query: 35 AKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDG 94 K K+R + + GP +AG + P ++S +++ E + E S+ + D G +G+ Sbjct: 464 VKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEE 523 Query: 95 ATGKKKKKKKKK--------RGPKV 111 +K + +K RGP V Sbjct: 524 VGLEKPSLEPQKSLGDEGLNRGPYV 548 >3H2Z-A nrPDB Length = 382 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 26/48 (54%), Gaps = 4/48 (8%) Query: 291 AGIDVRLCDVGEAIQEVM---ESYEVEIDGKTYQVKPIRNLNG-HSIG 334 AGI + DV + + + + SY+V + G+T QV + +N SIG Sbjct: 23 AGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIG 70 >6DEB-A nrPDB Length = 285 Score = 28.1 bits (61), Expect = 8.2, Method: Compositional matrix adjust. Identities = 10/43 (23%), Positives = 26/43 (60%) Query: 304 IQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPI 346 + +++++YE++++GK + N+ G + ++AG TV + Sbjct: 147 VMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSV 189 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1QZY-A nrPDB 764 0.0 5LYW-A nrPDB 590 e-169 3FMR-A nrPDB 344 7e-95 1XGN-A nrPDB 300 1e-81 2V6C-A nrPDB 277 7e-75 2Q8K-A nrPDB 276 1e-74 4IPA-A nrPDB 225 4e-59 4FO7-A nrPDB 211 7e-55 3TB5-A nrPDB 210 1e-54 3MR1-A nrPDB 205 4e-53 4KM3-A nrPDB 203 1e-52 1O0X-A nrPDB 194 7e-50 3S6B-A nrPDB 193 1e-49 1QXW-A nrPDB 175 3e-44 3Q6D-A nrPDB 132 3e-31 Sequences not found previously or not previously below threshold: 6MRF-A nrPDB 185 3e-47 4A6V-A nrPDB 178 5e-45 4IU6-A nrPDB 169 3e-42 2B3K-A nrPDB 166 1e-41 4FUK-A nrPDB 160 1e-39 3ROR-A nrPDB 151 5e-37 3TAV-A nrPDB 142 4e-34 5CNX-A nrPDB 101 8e-22 4RGZ-A nrPDB 89 5e-18 1WY2-A nrPDB 88 1e-17 1PV9-A nrPDB 86 2e-17 2ZSG-A nrPDB 86 2e-17 4PV4-A nrPDB 84 1e-16 2BWY-A nrPDB 83 3e-16 5WZE-A nrPDB 73 3e-13 4ZNG-C nrPDB 73 3e-13 3IG4-A nrPDB 61 1e-09 5APN-x nrPDB 56 4e-08 5MC5-A nrPDB 52 5e-07 1CHM-A nrPDB 52 6e-07 5X49-A nrPDB 50 2e-06 4QR8-A nrPDB 46 4e-05 3OHM-B nrPDB 36 0.050 5MPS-a nrPDB 31 1.8 5A5T-C nrPDB 31 1.9 5OCP-A nrPDB 30 2.3 5OQL-c nrPDB 29 3.8 3RAO-A nrPDB 29 4.5 6O9Z-L nrPDB 29 4.5 5FL8-r nrPDB 28 7.6 >1QZY-A nrPDB Length = 478 Score = 764 bits (1972), Expect = 0.0, Method: Composition-based stats. Identities = 477/478 (99%), Positives = 478/478 (100%) Query: 1 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES 60 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES Sbjct: 1 MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES 60 Query: 61 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI 120 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI Sbjct: 61 GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI 120 Query: 121 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 180 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR Sbjct: 121 CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR 180 Query: 181 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 240 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT Sbjct: 181 KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT 240 Query: 241 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 300 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV Sbjct: 241 VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV 300 Query: 301 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 360 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPI+KGGEATRMEEGEV Sbjct: 301 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIIKGGEATRMEEGEV 360 Query: 361 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 420 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL Sbjct: 361 YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL 420 Query: 421 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 478 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY Sbjct: 421 DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY 478 >5LYW-A nrPDB Length = 378 Score = 590 bits (1520), Expect = e-169, Method: Composition-based stats. Identities = 371/371 (100%), Positives = 371/371 (100%) Query: 108 GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWN 167 GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWN Sbjct: 2 GPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWN 61 Query: 168 DFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNN 227 DFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNN Sbjct: 62 DFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNN 121 Query: 228 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTG 287 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTG Sbjct: 122 CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTG 181 Query: 288 IKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIV 347 IKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIV Sbjct: 182 IKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIV 241 Query: 348 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN 407 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN Sbjct: 242 KGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVIN 301 Query: 408 ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPT 467 ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPT Sbjct: 302 ENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPT 361 Query: 468 CKEVVSRGDDY 478 CKEVVSRGDDY Sbjct: 362 CKEVVSRGDDY 372 >3FMR-A nrPDB Length = 358 Score = 344 bits (881), Expect = 7e-95, Method: Composition-based stats. Identities = 159/367 (43%), Positives = 219/367 (59%), Gaps = 26/367 (7%) Query: 118 VPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHR 177 +PI L +GV+ KG+ + S + + +I D R AAEAHR Sbjct: 12 LPIEFLPKDGVYGKGKLFD---------------SRNMEIENFTESDILQDARRAAEAHR 56 Query: 178 QVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAG 237 + R V S ++PG+T++EI +ED +R L+K N G+ FP G S+N+CAAHYT N G Sbjct: 57 RARYRVQSIVRPGITLLEIVRSIEDSTRTLLKGER-NNGIGFPAGMSMNSCAAHYTVNPG 115 Query: 238 DTT-VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVR 296 + VL+ DD+ KIDFGTH GRI+D AFTV F + LL A ++ T TGIK G+DVR Sbjct: 116 EQDIVLKEDDVLKIDFGTHSDGRIMDSAFTVAFKENLEPLLVAAREGTETGIKSLGVDVR 175 Query: 297 LCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRME 356 +CD+G I EV+ SYEVEI G+ + ++PI +L+GHSI Q+RIH G ++P V + TR++ Sbjct: 176 VCDIGRDINEVISSYEVEIGGRMWPIRPISDLHGHSISQFRIHGGISIPAVNNRDTTRIK 235 Query: 357 EGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNV---INENFGTL 413 YA+ETF +TGKG + D CSH++ N R K L+ V + ++ GTL Sbjct: 236 GDSFYAVETFATTGKGSIDDRPPCSHFVLNT----YKSRKLFNKDLIKVYEFVKDSLGTL 291 Query: 414 AFCRRWLDRLGESK--YLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEV 471 F R LD G K L ++ L +G++ PYPPL DI G AQFEHT+ L KEV Sbjct: 292 PFSPRHLDYYGLVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEV 351 Query: 472 VSRGDDY 478 ++RGDDY Sbjct: 352 LTRGDDY 358 >1XGN-A nrPDB Length = 295 Score = 300 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 115/302 (38%), Positives = 166/302 (54%), Gaps = 20/302 (6%) Query: 165 IWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCS 224 +A E ++VR+ + +PGM ++E+ E +E K+I E L AFP S Sbjct: 2 DTEKLMKAGEIAKKVREKAIKLARPGMLLLELAESIE----KMIME--LGGKPAFPVNLS 55 Query: 225 LNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDAT 284 +N AAHYTP GDTTVL+ D KID G HI G I D A TV + D L++A K+A Sbjct: 56 INEIAAHYTPYKGDTTVLKEGDYLKIDVGVHIDGFIADTAVTVRVGMEEDELMEAAKEAL 115 Query: 285 NTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTV 344 N I A V + ++G+AI+ EI + + KPI NL+GH I +Y++HAG ++ Sbjct: 116 NAAISVARAGVEIKELGKAIEN-------EIRKRGF--KPIVNLSGHKIERYKLHAGISI 166 Query: 345 P-IVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLL 403 P I + + ++EG+V+AIE F + G G V + YM D VP+R+ + + LL Sbjct: 167 PNIYRPHDNYVLKEGDVFAIEPFATIGAGQVIEVPPTLIYMYVRD---VPVRVAQARFLL 223 Query: 404 NVINENFGTLAFCRRWLDR-LGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTI 462 I +GTL F RWL + E + +ALK L G + YP L +I+ AQFEHTI Sbjct: 224 AKIKREYGTLPFAYRWLQNDMPEGQLKLALKTLEKAGAIYGYPVLKEIRNGIVAQFEHTI 283 Query: 463 LL 464 ++ Sbjct: 284 IV 285 >2V6C-A nrPDB Length = 353 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 78/328 (23%), Positives = 142/328 (43%), Gaps = 17/328 (5%) Query: 161 ASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK-----LEDCSRKLIKENGLNA 215 A + + ++ + +V + ++ G++++ +CEK +E+ + KE + Sbjct: 6 AEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKK 65 Query: 216 GLAFPTGCSLNNCAAHYTPNAGDT-TVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYD 274 G+AFPT S+NNC H++P D +L+ D+ KID G H+ G I + A T Sbjct: 66 GIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQG 125 Query: 275 TLLKAVK-DATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSI 333 T + K D CA +RL G +V E++ ++ PI + H + Sbjct: 126 TQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWN--KVAHSFNCTPIEGMLSHQL 183 Query: 334 GQYRIHAGKTV------PIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNF 387 Q+ I KT+ K E E EVYA++ S+G+G D + + K Sbjct: 184 KQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRD 243 Query: 388 DVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPL 447 +++ ++ + + F + F R + E K M + ++ P+ L Sbjct: 244 PSKQYGLKMKTSRAFFSEVERRFDAMPFALRAFE--DEKKARMGVVECAKHELLQPFNVL 301 Query: 448 CDIKGSYTAQFEHTILLRPTCKEVVSRG 475 + +G + AQF+ T+LL P ++ G Sbjct: 302 YEREGEFVAQFKFTVLLMPNGPMRITSG 329 >2Q8K-A nrPDB Length = 401 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 80/346 (23%), Positives = 149/346 (43%), Gaps = 17/346 (4%) Query: 143 GRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK--- 199 G + +E++ A + + ++ + +V + ++ G++++ +CEK Sbjct: 2 GHHHHHHSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDA 61 Query: 200 --LEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDT-TVLQYDDICKIDFGTHI 256 +E+ + KE + G+AFPT S+NNC H++P D +L+ D+ KID G H+ Sbjct: 62 MIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHV 121 Query: 257 SGRIIDCAFTVTFNPKYDTLLKAVK-DATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEI 315 G I + A T + T + K D CA +RL G +V E++ Sbjct: 122 DGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWN--K 179 Query: 316 DGKTYQVKPIRNLNGHSIGQYRIHAGKTV------PIVKGGEATRMEEGEVYAIETFGST 369 ++ PI + H + Q+ I KT+ K E E EVYA++ S+ Sbjct: 180 VAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSS 239 Query: 370 GKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYL 429 G+G D + + K +++ ++ + + F + F R + E K Sbjct: 240 GEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFE--DEKKAR 297 Query: 430 MALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRG 475 M + ++ P+ L + +G + AQF+ T+LL P ++ G Sbjct: 298 MGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSG 343 >4IPA-A nrPDB Length = 423 Score = 225 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 72/351 (20%), Positives = 125/351 (35%), Gaps = 39/351 (11%) Query: 152 SEEKKALDQA--SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK----LEDCSR 205 + EKK D S ++ ++ AA+ +V V PG +I+ICE+ +E+ Sbjct: 10 ATEKKEADNVAISVDVLTKYKTAAQISEKVLAEVSKLCVPGAKIIDICEQGDKLMEEELS 69 Query: 206 KLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTV----LQYDDICKIDFGTHISGR-I 260 K+ ++ N G + PT S YTP D +Q + KI G I G Sbjct: 70 KVYRDKKTNKGFSHPTTVSPAAFITPYTPLRSDEKEAATEIQPGEPIKIQLGAQIDGYGT 129 Query: 261 IDCAFTVTFNPKYDTLLKAV----------------KDATNTGIKCAGID---VRLCDVG 301 I C V N +++ + G+ G D + V Sbjct: 130 IVCDTIVAKNANDPDVIEGRQADLFLATYYANEVLLRLMVPPGLLATGTDEEKAKAAAVK 189 Query: 302 EAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATR----MEE 357 Q + S +E K Y I + + I K + I+ GE + E Sbjct: 190 PPSQAKISSL-LEKVAKAYDCNIIESTTSWLFDKNEIEGKKKI-ILSPGENIKGEGVPEV 247 Query: 358 GEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCR 417 G+V+ +E S G G V + + + + + ++ P ++ + + + + FGT F Sbjct: 248 GDVWGVEVGCSLGSGKVKQFEQRATLHRRTNNTYA-LKRPTSRKIYSEVQKKFGTFPFSL 306 Query: 418 RWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTC 468 R L+ E + G+ Y D + + TI + Sbjct: 307 RQLE--DERDAKSGVIECVRGGVFRQYEVTGDKDNAPVCRLLTTIAITKNG 355 >4FO7-A nrPDB Length = 280 Score = 211 bits (536), Expect = 7e-55, Method: Composition-based stats. Identities = 50/219 (22%), Positives = 81/219 (36%), Gaps = 18/219 (8%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIE---ICEKLEDCSRKLIKENGLNAGLA 218 + + R A +V + + IKPG+T E IC +K I G Sbjct: 7 TPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVNEQKAIPAPLNYKGFP 66 Query: 219 FPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCA--FTVTFNPKY-DT 275 S+N+ H PN L+ DI +D G D + F V P++ D Sbjct: 67 KSICTSINHVVCHGIPN---EKPLKEGDILNVDITVIKDGYHGDTSKMFLVGKTPEWADR 123 Query: 276 LLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQ 335 L + ++ GI L D+GE IQ+ E + +R GH IG+ Sbjct: 124 LCQITQECMYKGISVVRPGAHLGDIGEIIQKHAEKNGFSV---------VREYCGHGIGK 174 Query: 336 YRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVV 374 + + + G ++EG ++ IE + G+ Sbjct: 175 VFHEEPQVLHYGRAGTGIELKEGMIFTIEPMINQGRPET 213 >3TB5-A nrPDB Length = 264 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 68/239 (28%), Positives = 104/239 (43%), Gaps = 28/239 (11%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNA------ 215 S E+ E V +++ ++IKPG+T +I E R I+ +G A Sbjct: 6 SPREIEMMDESGELLADVHRHLRTFIKPGITSWDI----EVFVRDFIESHGGVAAQIGYE 61 Query: 216 GLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFN---PK 272 G + T CS+N+ H P VL+ D+ K+D + G I D ++ P+ Sbjct: 62 GYKYATCCSINDEICHGFPRK---KVLKDGDLIKVDMCVDLKGAISDSCWSYVVGESTPE 118 Query: 273 YDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHS 332 D L++ K A GI+ A + R+ D+G AIQ +E G+ Y V +R+ GH Sbjct: 119 IDRLMEVTKKALYLGIEQAQVGNRIGDIGHAIQTYVE-------GEGYGV--VRDFVGHG 169 Query: 333 IGQYRIHAGKTVPIVK-GGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVG 390 IG IH +P G+ R++EG V IE +TG + D D G Sbjct: 170 IGP-TIHESPMIPHYGEAGKGLRLKEGMVITIEPMVNTGTWRMKMDPN-GWTAYTEDGG 226 >3MR1-A nrPDB Length = 252 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 45/232 (19%), Positives = 80/232 (34%), Gaps = 17/232 (7%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDC--SRKLIKENGLNAGLAF 219 +E+ + R A + + ++ +KP +T + + + S I G Sbjct: 10 TEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFITSHNAIPAPLNYKGFPK 69 Query: 220 PTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNP---KYDTL 276 S+N+ H PN L+ DI ID + G D + K L Sbjct: 70 SICTSINHVVCHGIPNDKP---LKNGDIVNIDVTVILDGWYGDTSRMYYVGDVAIKPKRL 126 Query: 277 LKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQY 336 ++ DA GI+ +L D+G AIQ E + + +R+ GH IG+ Sbjct: 127 IQVTYDAMMKGIEVVRPGAKLGDIGYAIQSYAEKHNYSV---------VRDYTGHGIGRV 177 Query: 337 RIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFD 388 + + G ++EG + +E + G + D Sbjct: 178 FHDKPSILNYGRNGTGLTLKEGMFFTVEPMINAGNYDTILSKLDGWTVTTRD 229 >4KM3-A nrPDB Length = 286 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 107/277 (38%), Gaps = 61/277 (22%) Query: 151 TSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICE------KLEDCS 204 ++ E +A+D+A + A H +R IKPG+ M E+ E K E+ Sbjct: 6 SAREIEAMDKAGD-------FLASIHIGLRD----LIKPGVDMWEVEEYVRRRCKEENFL 54 Query: 205 RKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDF------------ 252 I +G + T CSLN+ AH P +L+ D+ K+D Sbjct: 55 PLQIGVDGAMMDYPYATCCSLNDEVAHAFPR---HYILKDGDLLKVDMVLGGPIAKSDLN 111 Query: 253 ---------------GTHISGRIIDCAFTVTFN---PKYDTLLKAVKDATNTGIKCAGID 294 SG + D + + L+ K+A GI+ A + Sbjct: 112 VSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVG 171 Query: 295 VRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVK-GGEAT 353 R+ D+G AIQE ES + Y V +R+L GH +G +H VP G Sbjct: 172 NRIGDIGAAIQEYAES-------RGYGV--VRDLVGHGVGP-TMHEEPMVPNYGIAGRGL 221 Query: 354 RMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVG 390 R+ EG V IE +TG + DM+ K D G Sbjct: 222 RLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGG 258 >1O0X-A nrPDB Length = 262 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 89/254 (35%), Gaps = 29/254 (11%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNA--GLAF 219 + ++A +A + V I PG T ++ + + +KL + G + Sbjct: 18 TPSEIEKMKKAGKAVAVALREVRKVIVPGKTAWDVETLVLEIFKKLRVKPAFKGYGGYKY 77 Query: 220 PTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTF---NPKYDTL 276 T S+N H P V + DI +D G G D A T + + L Sbjct: 78 ATCVSVNEEVVHGLPLK--EKVFKEGDIVSVDVGAVYQGLYGDAAVTYIVGETDERGKEL 135 Query: 277 LKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQY 336 ++ ++ IK +RL DV IQE +ES + IR+ GH +G+ Sbjct: 136 VRVTREVLEKAIKMIKPGIRLGDVSHCIQETVESVGFNV---------IRDYVGHGVGR- 185 Query: 337 RIHAGKTVPIVK-GGEATRMEEGEVYAIETFGSTGKGVV-----------HDDMECSHYM 384 +H +P G + +G AIE S G V D C+H+ Sbjct: 186 ELHEDPQIPNYGTPGTGVVLRKGMTLAIEPMVSEGDWRVVVKEDGWTAVTVDGSRCAHFE 245 Query: 385 KNFDVGHVPIRLPR 398 + + Sbjct: 246 HTILITENGAEILT 259 Score = 31.7 bits (70), Expect = 0.84, Method: Composition-based stats. Identities = 10/25 (40%), Positives = 16/25 (64%) Query: 450 IKGSYTAQFEHTILLRPTCKEVVSR 474 + GS A FEHTIL+ E++++ Sbjct: 236 VDGSRCAHFEHTILITENGAEILTK 260 >3S6B-A nrPDB Length = 368 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 56/215 (26%), Positives = 87/215 (40%), Gaps = 16/215 (7%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAG---LA 218 +EE REA R+ Y + + PG+T EI K+ + +IK N + Sbjct: 105 NEEEIQRIREACILGRKTLDYAHTLVSPGVTTDEIDRKVHEF---IIKNNAYPSTLNYYK 161 Query: 219 FPTGC--SLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTL 276 FP C S+N H P D L+ DI ID G D T F + + Sbjct: 162 FPKSCCTSVNEIVCHGIP---DYRPLKSGDIINIDISVFYKGVHSDLNETY-FVGDINDV 217 Query: 277 LKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQY 336 K K+ T ++ C G + + + + K + V +R+ +GH +G+ Sbjct: 218 PKEGKELVETCYFSLMEAIKKCKPGMFYKNIGTLIDAYVSKKNFSV--VRSYSGHGVGK- 274 Query: 337 RIHAGKTVPIVKGGEAT-RMEEGEVYAIETFGSTG 370 H+ TVP K +A M+ G V+ IE + G Sbjct: 275 LFHSNPTVPHFKKNKAVGIMKPGHVFTIEPMINQG 309 >6MRF-A nrPDB Length = 270 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 46/227 (20%), Positives = 76/227 (33%), Gaps = 24/227 (10%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIE---ICEKLEDCSRKLIKENGLNAG-- 216 + + R A +V + IK G++ +E IC + + I G Sbjct: 12 TPDEIEKMRIAGRLAAEVLDMIKPHIKAGVSTLELDTICRNHIENVQHAIPACVGYGGAP 71 Query: 217 ----LAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPK 272 S+N+ H P + +L+ DI ID G D + Sbjct: 72 GRPAFQHSICTSVNHVVCHGIP--SENKILKNGDILNIDVTVIKDGYHGDTNMMYIVGGE 129 Query: 273 ----YDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNL 328 + L K ++A G+ L D+G AIQ+ +ES + +R Sbjct: 130 TSILANRLCKVAQEAMYRGMATVRDGSYLGDIGHAIQKYVESERFSV---------VREY 180 Query: 329 NGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVH 375 GH IG + + + G R+E G + IE + G Sbjct: 181 CGHGIGTVFHDEPQVLHYGQAGTGMRLEAGMTFTIEPMVNAGVWQTK 227 >4A6V-A nrPDB Length = 265 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 82/233 (35%), Gaps = 18/233 (7%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIE---ICEKLEDCSRKLIKENGLNAGLA 218 + E R A +V + + ++KPG++ E IC + + G Sbjct: 7 TPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYP 66 Query: 219 FPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNP---KYDT 275 S+N H P D +L+ DI ID G D + + Sbjct: 67 KSVCISINEVVCHGIP--DDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGER 124 Query: 276 LLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQ 335 L + +++ ++ + L ++G AIQ+ +E+ + +R GH IG+ Sbjct: 125 LCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSV---------VREYCGHGIGR 175 Query: 336 YRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFD 388 + + ++ G + IE + GK + M+ +K D Sbjct: 176 GFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRT-MKDGWTVKTKD 227 >1QXW-A nrPDB Length = 252 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 96/246 (39%), Gaps = 28/246 (11%) Query: 158 LDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGL 217 + +EE +E +VR + + KPG+T ++L++ +++L +E G + Sbjct: 1 MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITT----KELDNIAKELFEEYGAISAP 56 Query: 218 ----AFP--TGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNP 271 FP T S+N AH P+ V++ D+ ID +G D + Sbjct: 57 IHDENFPGQTCISVNEEVAHGIPSK---RVIREGDLVNIDVSALKNGYYADTGISFVVGE 113 Query: 272 KYDTLLKAVKDATNTGIKCA----GIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRN 327 D + + V D + A +L ++G+A+ + +K I+N Sbjct: 114 SDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNT---------ARQNDLKVIKN 164 Query: 328 LNGHSIGQYRIHAG-KTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKN 386 L GH +G A + + T + EG V AIE F S+ V + + + Sbjct: 165 LTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEG-KNEWAFET 223 Query: 387 FDVGHV 392 D V Sbjct: 224 SDKSFV 229 >4IU6-A nrPDB Length = 384 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 107/329 (32%), Gaps = 36/329 (10%) Query: 71 LERSALEDKERDEDDE---DGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNG 127 L + A ++K + E +GD + D G + K + P + T P VP P+ Sbjct: 51 LHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRP--VPSYIQRPD- 107 Query: 128 VFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWI 187 ++P A + TS+ K S E R R+V I Sbjct: 108 ------YADHPLGMSESEQALKGTSQIKL----LSSEDIEGMRLVCRLAREVLDVAAGMI 157 Query: 188 KPGMTMIEICEKLED--CSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYD 245 KPG+T EI + +R S+N H P D LQ Sbjct: 158 KPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIP---DRRPLQEG 214 Query: 246 DICKIDFGTHISGRIIDCAFTVTFNPKYD---TLLKAVKDATNTGIKCAGIDVRLCDVGE 302 DI +D + +G D T D L++ + I VR ++G Sbjct: 215 DIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGN 274 Query: 303 AIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEAT-RMEEGEVY 361 IQ+ ++ + +R+ GH I + H VP +A M+ G V+ Sbjct: 275 IIQKHAQANGFSV---------VRSYCGHGIHK-LFHTAPNVPHYAKNKAVGVMKSGHVF 324 Query: 362 AIETFGSTGKGVVHDDMECSHYMKNFDVG 390 IE G + D Sbjct: 325 TIEPMICEGGWQ-DETWPDGWTAVTRDGK 352 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 11/24 (45%), Positives = 17/24 (70%) Query: 451 KGSYTAQFEHTILLRPTCKEVVSR 474 G +AQFEHT+L+ T E+++R Sbjct: 350 DGKRSAQFEHTLLVTDTGCEILTR 373 >2B3K-A nrPDB Length = 329 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 61/299 (20%), Positives = 94/299 (31%), Gaps = 33/299 (11%) Query: 107 RGPKVQTDP--------PSVPICDLYPNGVFPKGQE-CEYPPTQDGRTAAWRTTSEEKKA 157 RG + DP P P+ P + + + ++P A + TS+ K Sbjct: 17 RGSHMLEDPYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKL- 75 Query: 158 LDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLED--CSRKLIKENGLNA 215 S E R R+V IKPG+T EI + +R Sbjct: 76 ---LSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYY 132 Query: 216 GLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYD- 274 S+N H P D LQ DI +D + +G D T D Sbjct: 133 NFPKSCCTSVNEVICHGIP---DRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDG 189 Query: 275 --TLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHS 332 L++ + I VR ++G IQ+ ++ + +R+ GH Sbjct: 190 ARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSV---------VRSYCGHG 240 Query: 333 IGQYRIHAGKTVPIVKGGEAT-RMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVG 390 I + H VP +A M+ G V+ IE G + D Sbjct: 241 IHK-LFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQ-DETWPDGWTAVTRDGK 297 Score = 33.6 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 11/24 (45%), Positives = 17/24 (70%) Query: 451 KGSYTAQFEHTILLRPTCKEVVSR 474 G +AQFEHT+L+ T E+++R Sbjct: 295 DGKRSAQFEHTLLVTDTGCEILTR 318 >4FUK-A nrPDB Length = 337 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 48/226 (21%), Positives = 76/226 (33%), Gaps = 19/226 (8%) Query: 159 DQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLED--CSRKLIKENGLNAG 216 D + + R+V + KPG+T E+ + + R + G Sbjct: 62 DSKKTAEIQRIKTVCQLSREVLDIATAAAKPGITTDELDRIVHEATVERNMYPSPLNYYG 121 Query: 217 LAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYD-- 274 S+N H P D+ L+ DI ID ++++G D TV D Sbjct: 122 FPKSVCTSVNEVICHGIP---DSRELEEGDILNIDVSSYLNGFHGDLNETVFIGRPDDDS 178 Query: 275 -TLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSI 333 L+ A + GI + VG+AI+ YQ +R GH + Sbjct: 179 VRLVHAAYECLCAGIGVVKPEALYKQVGDAIEACAS---------QYQCSVVRTYTGHGV 229 Query: 334 GQYRIHAGKTVPIVKGGEAT-RMEEGEVYAIETFGSTGKGVVHDDM 378 G + H TV ++ M G V+ IE + G Sbjct: 230 G-HLFHTSPTVCHYANNKSLGMMRPGHVFTIEPMINLGTWQDVTWP 274 >3ROR-A nrPDB Length = 291 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 44/228 (19%), Positives = 71/228 (31%), Gaps = 17/228 (7%) Query: 149 RTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCS--RK 206 + ++E + E+ R A + PG+T E+ + Sbjct: 36 KPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNG 95 Query: 207 LIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFT 266 G SLN H P D+TV+ DI ID +I G D T Sbjct: 96 AYPSTLGYKGFPKSCSTSLNEVICHGIP---DSTVITDGDIVNIDVTAYIGGVHGDTNAT 152 Query: 267 VTFNPKYDT---LLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVK 323 D L+ ++AT I L +G I+ + + Sbjct: 153 FPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNV-------- 204 Query: 324 PIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGK 371 +R+ GH IG + + + T M+ G + IE + G Sbjct: 205 -VRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGA 251 >3TAV-A nrPDB Length = 286 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 93/263 (35%), Gaps = 23/263 (8%) Query: 155 KKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKL--IKENG 212 KK ++Q + + A V K G++ +E+ + E R+ + Sbjct: 29 KKTVEQRTPGELDAMAAAGSIVGAALVAVRDAAKAGVSTLELDQVAESVIREAGAVPSFL 88 Query: 213 LNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFN-- 270 G S+N+ H P T VL D+ ID G + G D A+T Sbjct: 89 GYHGFPASICSSVNDQVVHGIP--SATAVLADGDLVSIDCGAILDGWHGDSAWTFAVGTV 146 Query: 271 -PKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLN 329 P + L +A + + GI RL DV AI+ + E + D + + + + Sbjct: 147 IPSDEALSEATRLSMEAGIAAMIPGNRLTDVSHAIELGTRAAEKQFD-RAFGI--VDGYG 203 Query: 330 GHSIGQYRIHAGKTVPI-VKGGEATRMEEGEVYAIETFGSTGKGVVH-----------DD 377 GH IG+ +H +P G+ + G V AIE + G D Sbjct: 204 GHGIGRS-MHLDPFLPNEGAPGKGPLLAVGSVLAIEPMLTLGTTQTRVLADDWTVVTTDG 262 Query: 378 MECSHYMKNFDVGHVPIRLPRTK 400 +H+ V R+ + Sbjct: 263 SRAAHWEHTVAVTEAGPRILTMR 285 >3Q6D-A nrPDB Length = 356 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 44/214 (20%), Positives = 75/214 (35%), Gaps = 16/214 (7%) Query: 154 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGL 213 EK L + EI +EAA+ ++++S+I+PG++ IE+ +LE R K+ Sbjct: 125 EKLRLIKTDSEI-KILKEAAQIADAAFEHILSFIRPGVSEIEVSNELEFFMR---KQGAT 180 Query: 214 NAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKY 273 ++ L + H V++ D +DFG + G D T+ Sbjct: 181 SSSFDIIVASGLRSALPHGV---ASEKVIETGDFVTLDFGAYYKGYCSDITRTIAVGEPS 237 Query: 274 DTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSI 333 D L + ++ ++ G + Y E Y GH I Sbjct: 238 DKLKEIYNIVLEAQLRGVN-GIKAGLTGREADALTRDYITEKGYGEYFGHS----TGHGI 292 Query: 334 GQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFG 367 G IH + T +E G +E Sbjct: 293 G-LEIHEAPGLAFRSD---TVLEPGMAVTVEPGI 322 >5CNX-A nrPDB Length = 361 Score = 101 bits (251), Expect = 8e-22, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 75/247 (30%), Gaps = 39/247 (15%) Query: 142 DGRTAAWRTTSEEKKALDQA-------------SEEIWNDFREAAEAHRQVRKYVMSWIK 188 +G+ +W T + L+ + E R A + +++ +I+ Sbjct: 96 EGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQ 155 Query: 189 PGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDIC 248 GM+ EI +LE R ++ A H ++ + Sbjct: 156 AGMSEREIAAELEWFMR---QQGAEKASFDTIVASGWRGALPHG---KASDKIVAAGEFV 209 Query: 249 KIDFGTHISGRIIDCAFTVTFNPKYD--------TLLKAVKDATNTGIKCAGIDVRLCDV 300 +DFG G D T+ N + + + V A I VR V Sbjct: 210 TLDFGALYQGYCSDMTRTLLVNGEGVSAESHLLFNVYQIVLQAQLAAISAIRPGVRCQQV 269 Query: 301 GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV 360 +A + V+ G + GH+IG P + T ++ G + Sbjct: 270 DDAARRVITEAGY---GDYFGHN-----TGHAIGIEVHED----PRFSPRDTTTLQPGML 317 Query: 361 YAIETFG 367 +E Sbjct: 318 LTVEPGI 324 >4RGZ-A nrPDB Length = 367 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 85/268 (31%), Gaps = 27/268 (10%) Query: 100 KKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALD 159 K K+ K G K+ D D P GVF K ++ + + + E K Sbjct: 93 KIKETFKEGEKLLID-------DTMPVGVFLKAKDI-FDKYSLHPISPVISELREIK--- 141 Query: 160 QASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAF 219 ++ ++AAE +V + G + E+ ++E + + ++ Sbjct: 142 --DKDEIKAHKKAAEIVDKVFYRFIEGKLEGKSERELANRIEYMIKNEFGADDVS--FEP 197 Query: 220 PTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKA 279 N H+ P ++ D+ D+G G D TV P + + K Sbjct: 198 IVASGPNGANPHHRP---SHRKIRKGDVVIFDYGAKYLGYCSDVTRTVVVGPPSEEVKKV 254 Query: 280 VKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIH 339 + + A V E + I Y I GH +G Sbjct: 255 -YEIVKEAQETAVQKVAEGIPAEVVDATARGI---ISKYGYGEYFIHR-TGHGLGIDVHE 309 Query: 340 AGKTVPIVKGGEATRMEEGEVYAIETFG 367 P + G +++G V+ IE Sbjct: 310 E----PYISPGNKKILKDGMVFTIEPGI 333 >1WY2-A nrPDB Length = 351 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 32/209 (15%), Positives = 61/209 (29%), Gaps = 21/209 (10%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT 221 SE+ +A E + + I G E+ K+E + Sbjct: 129 SEKEIKIIEKACEIADKAVMAAIEEITEGKKEREVAAKVEYLMK---MNGAEKPAFDTII 185 Query: 222 GCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTF---NPKYDTLLK 278 + H ++ D+ ID G D T+ N K + + Sbjct: 186 ASGYRSALPHGV---ASDKRIERGDLVVIDLGALYQHYNSDITRTIVVGSPNEKQKEIYE 242 Query: 279 AVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRI 338 V +A ++ A + ++ + ++ Y G+ + GH +G Sbjct: 243 IVLEAQKKAVESAKPGITAKELDSIARNIIAEYGY---GEYFNHS-----LGHGVGLEVH 294 Query: 339 HAGKTVPIVKGGEATRMEEGEVYAIETFG 367 + + T + EG V IE Sbjct: 295 EWPRVSQY----DETVLREGMVITIEPGI 319 >1PV9-A nrPDB Length = 348 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 75/230 (32%), Gaps = 29/230 (12%) Query: 149 RTTSEEKKALDQA--------SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKL 200 ++ +E K +D ++E +A E + + I G E+ K+ Sbjct: 105 KSNVKEFKKIDDVIKDLRIIKTKEEIEIIEKACEIADKAVMAAIEEITEGKREREVAAKV 164 Query: 201 EDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRI 260 E + + H ++ D+ ID G + Sbjct: 165 EYLMK---MNGAEKPAFDTIIASGHRSALPHGV---ASDKRIERGDLVVIDLGALYNHYN 218 Query: 261 IDCAFTVTF---NPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDG 317 D T+ N K + + V +A ++ A + ++ +E+++ Y Sbjct: 219 SDITRTIVVGSPNEKQREIYEIVLEAQKRAVEAAKPGMTAKELDSIAREIIKEY------ 272 Query: 318 KTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFG 367 Y I +L GH +G IH + + T ++EG V IE Sbjct: 273 -GYGDYFIHSL-GHGVGL-EIHEWPRISQY---DETVLKEGMVITIEPGI 316 >2ZSG-A nrPDB Length = 359 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 43/209 (20%), Positives = 66/209 (31%), Gaps = 21/209 (10%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT 221 E ++A E + + I+ GMT EI LE R KE Sbjct: 135 DEGEIEKIKQAIEISERAFLETVQQIRAGMTEKEIAALLEYTMR---KEGAEGVAFDTIV 191 Query: 222 GCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKA-- 279 + H V++ D+ IDFG D V+ D + + Sbjct: 192 ASGCRSALPHG---KASDKVVERGDVIVIDFGATYENYCADITRVVSIGEPSDEVKEVHS 248 Query: 280 -VKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRI 338 V +A +K A V G+ + V + I K Y +L GH IG Sbjct: 249 IVLEAQERALKIAKAGV----TGKLLDSVAREF---IREKGYGEFFGHSL-GHGIGLEVH 300 Query: 339 HAGKTVPIVKGGEATRMEEGEVYAIETFG 367 P + + + E V+ +E Sbjct: 301 EG----PAISFRNDSPLPENVVFTVEPGI 325 >4PV4-A nrPDB Length = 445 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 47/237 (19%), Positives = 73/237 (30%), Gaps = 31/237 (13%) Query: 148 WRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKL 207 WR E + A E R A E M +PGM ++ ++ + Sbjct: 163 WRPWLHEMRLFKSA--EEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEI---LHEF 217 Query: 208 IKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTV 267 + G N C HYT N + L+ D+ ID G G D T Sbjct: 218 TRHGARYPAYNTIVGGGENGCILHYTENECE---LRDGDLVLIDAGCEYRGYAGDITRTF 274 Query: 268 TFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRN 327 N K+ +AV D I + R G +I+EV E + ++ ++ Sbjct: 275 PVNGKFTPAQRAVYDIVLAAINKSLTLFR---PGTSIREVTEEVVRIMVVGLVELGILKG 331 Query: 328 ---------------LNG--HSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFG 367 ++G H +G G +E G V +E Sbjct: 332 DIEQLIAEQAHRPFFMHGLSHWLGMDVHDVG---DYGSSDRGRILEPGMVLTVEPGL 385 >2BWY-A nrPDB Length = 440 Score = 82.5 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 42/233 (18%), Positives = 71/233 (30%), Gaps = 24/233 (10%) Query: 148 WRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKL 207 WR E + S E R A E M +PGM + ++ Sbjct: 165 WRPVVHEMRLF--KSPEEIAVLRRAGEITAMAHTRAMEKCRPGMFEYHLEGEIHHEFN-- 220 Query: 208 IKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTV 267 + G N C HYT N + ++ D+ ID G G D T Sbjct: 221 -RHGARYPSYNTIVGSGENGCILHYTENECE---MRDGDLVLIDAGCEYKGYAGDITRTF 276 Query: 268 TFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRN 327 N K +A ++ + ++ +RL G +I EV + ++ ++ Sbjct: 277 PVNGK---FTQAQREIYDIVLESLETSLRLYRPGTSILEVTGEVVRIMVSGLVKLGILKG 333 Query: 328 LNGHSIGQ-----YRIHA--------GKTVPIVKGGEATRMEEGEVYAIETFG 367 I Q + +H V + + +E G V + Sbjct: 334 DVDELIAQNAHRPFFMHGLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVAPGL 386 >5WZE-A nrPDB Length = 452 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 43/220 (19%), Positives = 65/220 (29%), Gaps = 23/220 (10%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT 221 S R AAE + M +PG+ + +LE R K Sbjct: 177 SANEVKVMRYAAEVSARAHIRAMEVCRPGLFEYHLEAELEYEFR---KGGAKMPAYGSIV 233 Query: 222 GCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTV----TFNPKYDTLL 277 N C HY N ++ D+ ID G I D T F+P+ + Sbjct: 234 AAGRNACILHYRENDA---AIKDGDLILIDAGCEIDCYASDITRTFPANGRFSPEQKAIY 290 Query: 278 KAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNL--------- 328 + V +A + EA V+ + V + V + Sbjct: 291 ELVLEANMAAFDYIAPGRHWNEAHEATVRVITAGLVRLGLLEGDVDELIAHEAYKAFYMH 350 Query: 329 -NGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFG 367 GH +G G+ GGE +E G +E Sbjct: 351 RAGHWLGMDVHDVGE---YRVGGEWRVLEPGMAMTVEPGI 387 >4ZNG-C nrPDB Length = 362 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 34/219 (15%), Positives = 70/219 (31%), Gaps = 24/219 (10%) Query: 154 EKKALDQASEEIWNDFREAAEAHRQVRK--YVMSWIKPGMTMIEICEKLEDCSRKLIKEN 211 E+ L + S + + A + + + + + + G+T +I K+E +++ Sbjct: 129 ERMRLIK-SADEIEKMKVAGDFADKCFEIGFATAAERNGVTESDIVAKIEYEMKRM---G 184 Query: 212 GLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNP 271 H P + +Q + + D G G D T+ Sbjct: 185 VPQMSFDTLVLSGARAANPHGAP---ENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQ 241 Query: 272 KYD---TLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNL 328 D + K VK+A + V +V ++++ G+ + + Sbjct: 242 PNDFDAEIHKIVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGY---GEYFNHR----- 293 Query: 329 NGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFG 367 GH IG V G ++EG ++ E Sbjct: 294 LGHGIGMDVHEYPSIV----AGNDLVIQEGMCFSNEPGI 328 >3IG4-A nrPDB Length = 427 Score = 61.3 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 60/190 (31%), Gaps = 16/190 (8%) Query: 183 VMSWIKPGMTMIEICEKLEDCSRKL-IKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTV 241 V+ K M E+ + + + IK + N N HY N Sbjct: 194 VLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNT----ILASGKNATVLHYEDNDAQ--- 246 Query: 242 LQYDDICKIDFGTHISGRIIDCAFTV----TFNPKYDTLLKAVKDATNTGIKCAGIDVRL 297 +Q D+ +D G D ++T TF+ + + V +A + ++ Sbjct: 247 IQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEIIKPGLKF 306 Query: 298 CDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEE 357 + E ++V+ + + + H + + V K +EE Sbjct: 307 AALNEHAKKVLAEGCKAVGLIQED-EELSKYYYHGVSHFLGLDTHDVGTYKDR---VLEE 362 Query: 358 GEVYAIETFG 367 G V IE Sbjct: 363 GMVITIEPGL 372 >5APN-x nrPDB Length = 616 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 53/152 (34%), Gaps = 34/152 (22%) Query: 163 EEIWNDFREAAEAHRQVRKYVMSWIKPG---------MTMIEICEKLEDC----SRKLIK 209 E + N +R A + + KYV S I +T+ E+C + + K Sbjct: 45 ESVLNKYRTAGQIAQTALKYVTSLINDSYHSKTTQRQLTVPELCLLTDSFILTRLEQYYK 104 Query: 210 ENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT-------------------VLQYDDICKI 250 G+A PT ++ + + P DT L+ D+ KI Sbjct: 105 NKVNERGIAIPTTIDIDQISGGWCPEIDDTQNLLNWNKGKDSTFASSVTGTLRPGDLVKI 164 Query: 251 DFGTHISGRIIDCAFTVTFNP--KYDTLLKAV 280 G HI G + + T+ P + +L+ Sbjct: 165 TLGVHIDGYTSEVSHTMVIYPVDETKPILQPT 196 >5MC5-A nrPDB Length = 478 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 34/230 (14%), Positives = 66/230 (28%), Gaps = 26/230 (11%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT 221 ++ R + + + VM +K GM E+ E + ++ Sbjct: 183 TDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYC--YSRGGMRHSSYTCIC 240 Query: 222 GCSLNNCAAHY-TPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAV 280 G N+ HY A + +Q D+C D G D + N K+ KAV Sbjct: 241 GSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAV 300 Query: 281 KDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNL------------ 328 +A + ++ + + + +E + + Sbjct: 301 YEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMP 360 Query: 329 --NGHSIGQYRIH--------AGKTVPIVKGGEATR-MEEGEVYAIETFG 367 GH +G P ++ R ++ G V +E Sbjct: 361 HGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGI 410 >1CHM-A nrPDB Length = 401 Score = 51.7 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 59/164 (35%), Gaps = 15/164 (9%) Query: 223 CSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYD---TLLKA 279 +N AH N T + DI ++ I+G T+ + D L + Sbjct: 223 SGINTDGAH---NPVTTRKVNKGDILSLNCFPMIAGYYTALERTLFLDHCSDDHLRLWQV 279 Query: 280 VKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIH 339 + G+K R D+ + E+ ++V + +T+ GHS G + Sbjct: 280 NVEVHEAGLKLIKPGARCSDIARELNEIFLKHDV-LQYRTFGY-------GHSFGTLSHY 331 Query: 340 AGKTVPI-VKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSH 382 G+ + ++ T +E G V ++E +G+ H Sbjct: 332 YGREAGLELREDIDTVLEPGMVVSMEPMIMLPEGLPGAGGYREH 375 >5X49-A nrPDB Length = 456 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 33/226 (14%), Positives = 69/226 (30%), Gaps = 24/226 (10%) Query: 154 EKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGL 213 ++ L ++ EI + A + Q M K + + K E R Sbjct: 190 QRLRLIKSPAEI-ERMQIAGKLTSQAFIETMFTSKAPVEEAFLYAKFEFECR---ARGAD 245 Query: 214 NAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFN--- 270 + HY + +++ ++ +D G S + D T N Sbjct: 246 ILAYPPVVAGGNRSNTLHYV---KNNQLIKDGEMVLLDGGCESSCYVSDITRTWPVNGRF 302 Query: 271 -----PKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEID-GKTYQVKP 324 Y+ +L+ +D ++ + I + ++ + + + K Sbjct: 303 TAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLIGQKLKDLGIMKNIKENNAFKA 362 Query: 325 IRNLNGHSIGQYR---IHAGKTVPIVKGGEATRMEEGEVYAIETFG 367 R H +G Y +H +P + ++ G V IE Sbjct: 363 ARKYCPHHVGHYLGMDVHDTPDMP-----RSLPLQPGMVITIEPGI 403 >4QR8-A nrPDB Length = 443 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 38/235 (16%), Positives = 65/235 (27%), Gaps = 39/235 (16%) Query: 162 SEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPT 221 +E REA + + + GM+ +I L + + + Sbjct: 163 TEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDI------NIAYLTATGHRDTDVPYSN 216 Query: 222 GCSLNN--CAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYD--TLL 277 +LN HYT D + +D G +G D T + D L+ Sbjct: 217 IVALNEHAAVLHYT--KLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLV 274 Query: 278 KAVKDATNTGIKCAGIDV-----------RLCDVGEAIQEVMESYEVEIDGKTYQVKPIR 326 K V D I V R+ + Q + + E + + Sbjct: 275 KDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMP 334 Query: 327 NLNGHSIGQYRIH--------------AGKTVPIVKGGEATRMEEGEVYAIETFG 367 + GH +G A P ++ ++ G V IE Sbjct: 335 HGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTR--ILQPGMVLTIEPGI 387 >3OHM-B nrPDB Length = 885 Score = 35.5 bits (80), Expect = 0.050, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 98/282 (34%), Gaps = 57/282 (20%) Query: 36 KKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGA 95 K K+R + + GP +AG + P ++S +++ E + E S+ + D G +G+ Sbjct: 465 KNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEV 524 Query: 96 TGKKKKKKKKK--------RGPKV-----------------QTDPPSVPICDLYPNGVFP 130 +K + +K RGP V QTDP Sbjct: 525 GLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDP--------------- 569 Query: 131 KGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPG 190 + P T +G ++ +EE L E + EAA + + + S+++ Sbjct: 570 -----KKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFE-MSSFVET- 622 Query: 191 MTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTV---LQYDDI 247 M ++ + + + L+ T +N N G V Q D+ Sbjct: 623 KAMEQLTKSPMEFVE--YNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDV 680 Query: 248 -CKIDFGTH----ISGRIIDCAFTVTFNPKYDTLLKAVKDAT 284 +++ G SG ++ F + +D + + D Sbjct: 681 AMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGI 722 >5MPS-a nrPDB Length = 251 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 1/62 (1%) Query: 28 ASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDED 87 AS + KK+++ SKG ++ A++DE RQ+E+ + D+E D++ Sbjct: 6 ASILKGEISKKKKELANSKGVQPPCTEKFQPHESANIDETPRQVEQES-TDEENLSDNQS 64 Query: 88 GD 89 D Sbjct: 65 DD 66 >5A5T-C nrPDB Length = 843 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 6/43 (13%) Query: 72 ERSALEDKERDEDD------EDGDGDGDGATGKKKKKKKKKRG 108 E+SA ED E++E+D ED D DG A KKK + G Sbjct: 94 EQSADEDAEKNEEDSEGSSDEDEDEDGVSAAAFLKKKAEAPSG 136 >5OCP-A nrPDB Length = 302 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 31/71 (43%) Query: 140 TQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEK 199 +Q G + WRT+ E + I F +A + K V S+I G+ I I Sbjct: 6 SQVGSESGWRTSFSEAVKAEAKQRGIDLKFADAQQKQENQIKAVRSFIAQGVDAIIIAPV 65 Query: 200 LEDCSRKLIKE 210 +E + ++KE Sbjct: 66 VETGWKPVLKE 76 >5OQL-c nrPDB Length = 785 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 24/59 (40%) Query: 53 EQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKV 111 E E + A V+ + + R +D ED ED D K +K ++R K+ Sbjct: 425 ELETKRPDDADVERAEQDVRRDLFDDLSEHEDSEDALSDASAGDPKSRKSAHERRQAKI 483 >3RAO-A nrPDB Length = 371 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 29/101 (28%), Positives = 43/101 (42%), Gaps = 15/101 (14%) Query: 30 TAEEAAKK----KRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDD 85 T EE + K K R+KK + +EP + G + + R E ALE+ R D Sbjct: 228 TVEEVSVKIEDMKNRRKKVT--------EEPLQSFGLAAYVICRHTEEEALEEWRRITDV 279 Query: 86 EDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPN 126 +D D G G + K + +V+ + SV L PN Sbjct: 280 KD---DALGYAGYQDFVSKSQLEQQVKLNDYSVSNRGLRPN 317 >6O9Z-L nrPDB Length = 323 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 19/65 (29%), Positives = 33/65 (50%), Gaps = 2/65 (3%) Query: 22 DREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKER 81 +R EG + ++ A K + ++K + + EP + E+ARQ+ER E+ E Sbjct: 251 ERTEGLSVLSQAMAVIKEKIEEKRGVFNV--QMEPKVVTDTDETELARQMERLERENAEV 308 Query: 82 DEDDE 86 D DD+ Sbjct: 309 DGDDD 313 >5FL8-r nrPDB Length = 767 Score = 28.2 bits (61), Expect = 7.6, Method: Composition-based stats. Identities = 32/125 (25%), Positives = 47/125 (37%), Gaps = 29/125 (23%) Query: 3 GVEEVAASGSHLNGDLDPD-----DREEGAASTAEEAAKKKRRKKKKSKGPSAA------ 51 GV A S L D+ P+ DR + AA +EA K + K+ G + Sbjct: 477 GVNMAAKSLIALYRDVAPEMLKKKDRGKNAAMEVQEAKKGGKDSKRPQFGADNSVQGIAG 536 Query: 52 -----------GEQEPDKESGASVDEVARQLERSAL-------EDKERDEDDEDGDGDGD 93 GE+ ++++ A+ + E DKE D D ED D + D Sbjct: 537 IELLAKWKKEHGEESENEDADANWEVDVDSEEDDVDGEWVTMDSDKEYDVDMEDSDDEKD 596 Query: 94 GATGK 98 A GK Sbjct: 597 NAKGK 601 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.126 0.330 Lambda K H 0.267 0.0379 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,690,835 Number of Sequences: 36641 Number of extensions: 755401 Number of successful extensions: 3306 Number of sequences better than 10.0: 113 Number of HSP's better than 10.0 without gapping: 114 Number of HSP's successfully gapped in prelim test: 104 Number of HSP's that attempted gapping in prelim test: 2353 Number of HSP's gapped (non-prelim): 692 length of query: 478 length of database: 10,336,785 effective HSP length: 101 effective length of query: 377 effective length of database: 6,636,044 effective search space: 2501788588 effective search space used: 2501788588 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.5 bits) S2: 61 (28.2 bits)