BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P50336 (477 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4IVM-B nrPDB 943 0.0 2IVE-A nrPDB 159 3e-39 3I6D-A nrPDB 146 2e-35 3LOV-A nrPDB 110 2e-24 1SEZ-A nrPDB 86 4e-17 2BXR-A nrPDB 46 3e-05 1O5W-A nrPDB 44 1e-04 1REO-A nrPDB 41 0.001 3KVE-A nrPDB 41 0.001 3RHA-A nrPDB 40 0.003 3WE0-A nrPDB 38 0.008 1F8S-A nrPDB 38 0.011 3BI4-A nrPDB 36 0.039 3NK2-X nrPDB 35 0.061 4IV9-A nrPDB 34 0.16 5MOG-A nrPDB 33 0.21 2JB2-A nrPDB 33 0.23 3ABT-A nrPDB 33 0.39 5L3D-A nrPDB 32 0.41 2VVL-G nrPDB 32 0.64 4RXL-A nrPDB 32 0.81 5L46-A nrPDB 31 0.97 5TWC-A nrPDB 31 0.99 5ZYN-B nrPDB 31 1.2 3C8T-A nrPDB 30 1.6 4P9S-A nrPDB 30 1.7 3GDN-A nrPDB 30 1.7 4DGK-A nrPDB 30 2.0 3FPZ-A nrPDB 30 2.1 3RED-A nrPDB 30 2.2 2BK5-A nrPDB 30 2.4 3UKH-A nrPDB 30 2.5 1RP0-A nrPDB 30 3.0 5TUL-A nrPDB 30 3.1 3L1R-A nrPDB 29 4.0 3ATQ-A nrPDB 29 4.2 5TUM-A nrPDB 29 4.9 4ZZQ-A nrPDB 28 6.2 4FWE-A nrPDB 28 6.2 4C5O-A nrPDB 28 8.2 5ZBC-A nrPDB 28 9.2 5TUF-A nrPDB 28 10.0 >4IVM-B nrPDB Length = 483 Score = 943 bits (2437), Expect = 0.0, Method: Compositional matrix adjust. Identities = 476/477 (99%), Positives = 476/477 (99%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGP G Sbjct: 7 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPGG 66 Query: 61 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP 120 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP Sbjct: 67 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP 126 Query: 121 PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI 180 PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI Sbjct: 127 PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI 186 Query: 181 RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL 240 RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL Sbjct: 187 RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL 246 Query: 241 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA 300 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA Sbjct: 247 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA 306 Query: 301 PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP 360 PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP Sbjct: 307 PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP 366 Query: 361 PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP 420 PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP Sbjct: 367 PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP 426 Query: 421 QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS 477 QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS Sbjct: 427 QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS 483 >2IVE-A nrPDB Length = 478 Score = 159 bits (402), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 158/494 (31%), Positives = 234/494 (47%), Gaps = 63/494 (12%) Query: 2 GRTVVVLGGGISGLAASYHL-SRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 G V V+GGGISGLA ++HL SR VL+ESS RLGG + G + E GP Sbjct: 16 GMNVAVVGGGISGLAVAHHLRSRGT---DAVLLESSARLGGAV-GTHALAGYLVEQGPNS 71 Query: 61 I---RPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLR 117 PA T L + L L+ + R PAA+ R++Y G L ++P L Sbjct: 72 FLDREPA------TRALAAALNLEGRI---RAADPAAKRRYVYTRGRLRSVPASPPAFLA 122 Query: 118 PSP-PFSKPLFWAGLRELTKPRGKE-PDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNS 175 P L AG EL R E DE++ +F +R LG + +D++ G++AG+ Sbjct: 123 SDILPLGARLRVAG--ELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDV 180 Query: 176 RELSIRSCFPSLFQAEQTHRSILLGLL----------LGAGRTPQPDSALIRQALAERWS 225 +LS+ + FP L + E+ HRS++LG + L AG P+ AL Sbjct: 181 EQLSVAATFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGAL---------- 230 Query: 226 QWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSL----RDSSLEADH 281 + GGL++L AL L G + G V GL+ + +G W++ + R + L Sbjct: 231 -STFDGGLQVLIDALAASL---GDAAHVGARVEGLARE-DGGWRLIIEEHGRRAELSVAQ 285 Query: 282 VISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSED 340 V+ A PA ++LL LA ++ I +AVV+L + LP GFG LVP+ E Sbjct: 286 VVLAAPAHATAKLLRPLDDALAALVAGIAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQ 345 Query: 341 PGVLGIVYDSVAFPEQDGSPPGLRV--TVMLGGSWLQTLEASGCVLSQELFQQRAQEAAA 398 +LG ++ S FP + G RV + M+GG+ L ++ A+E Sbjct: 346 RRMLGAIHASTTFPFR---AEGGRVLYSCMVGGARQPGLVEQ----DEDALAALAREELK 398 Query: 399 TQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLP-LTLAGASYEGVAVN 457 G+ PS V IPQY LGH +++ + L RLP L L G +Y+GV +N Sbjct: 399 ALAGVTARPSFTRVFRWPLGIPQYNLGHLERVAAIDAAL--QRLPGLHLIGNAYKGVGLN 456 Query: 458 DCIESGRQAAVSVL 471 DCI + Q A +++ Sbjct: 457 DCIRNAAQLADALV 470 >3I6D-A nrPDB Length = 470 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 138/492 (28%), Positives = 236/492 (47%), Gaps = 55/492 (11%) Query: 3 RTVVVLGGGISGLAASYHLSR----APCPPKVVLVESSERLGGWIRSVRGPNGAIFELGP 58 + VV++GGGI+GLAA++++ + P ++ LVE+S R+GG I++V+ +G I E GP Sbjct: 6 KHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQTVK-KDGYIIERGP 64 Query: 59 RGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTG-LRGLLR 117 + LV +LGL+ ++ + A ++ V LH +P G + G+ Sbjct: 65 DSFLERKKSAPQ---LVKDLGLEHLLV-----NNATGQSYVLVNRTLHPMPKGAVMGIPT 116 Query: 118 PSPPF-SKPLF------WAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGV 170 PF S LF A + + + D+++ F +RR+G EV ++ L G+ Sbjct: 117 KIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRVGDEVVENLIEPLLSGI 176 Query: 171 FAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQW-SL 229 +AG+ +LS+ S FP +Q EQ HRS++LG+ + +P + +Q A++ Q+ +L Sbjct: 177 YAGDIDKLSLMSTFPQFYQTEQKHRSLILGM-----KKTRPQGSG-QQLTAKKQGQFQTL 230 Query: 230 RGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDS-SLEADHVISAIP- 287 GL+ L + +E L + V +G V LS + + + L + +L+AD VI P Sbjct: 231 STGLQTLVEEIEKQL--KLTKVYKGTKVTKLS-HSGSCYSLELDNGVTLDADSVIVTAPH 287 Query: 288 ---ASVLSELLPAEAAPLARALSAITAVSVAVVNLQY-QGA-HLPVQGFGHLVPSSEDPG 342 A +LSEL P L + + SVA V L + +G+ + +G G ++ + D Sbjct: 288 KAAAGMLSEL------PAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVISRNSDFA 341 Query: 343 VLGIVYDSVAFPEQDGSPPG---LRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAAT 399 + + + +P +P G LR V G + S LS E Sbjct: 342 ITACTWTNKKWPH--AAPEGKTLLRAYVGKAG------DESIVDLSDNDIINIVLEDLKK 393 Query: 400 QLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDC 459 + + P V +PQY +GH Q+++ R+ L + + + GAS+EGV + DC Sbjct: 394 VMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGIPDC 453 Query: 460 IESGRQAAVSVL 471 I+ G+ A L Sbjct: 454 IDQGKAAVSDAL 465 >3LOV-A nrPDB Length = 475 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 121/483 (25%), Positives = 207/483 (42%), Gaps = 41/483 (8%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + +V++GGGI+GLAA+Y+ RA + L+E+ ERLGG + + R +G E GP Sbjct: 5 KRLVIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGGKVATYR-EDGFTIERGPDSY- 62 Query: 63 PAGALGARTLL--LVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGL-------R 113 + + +L L+ +GL ++ VR + A F+ G LH +P G Sbjct: 63 ----VARKHILTDLIEAIGLGEKL--VRNNTSQA---FILDTGGLHPIPKGAVMGIPTDL 113 Query: 114 GLLRPSPPFSKPLFWAGLRELTKP----RGKEPDETVHSFAQRRLGPEVASLAMDSLCRG 169 L R + ++ L P R E D + + + RLG + ++ L G Sbjct: 114 DLFRQTTLLTEEEKQEVADLLLHPSDSLRIPEQDIPLGEYLRPRLGDALVEKLIEPLLSG 173 Query: 170 VFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGA--GRTPQPDSALIRQALAERWSQW 227 ++AGN ++S + +P EQ S+ G+ L + PQ I+ Sbjct: 174 IYAGNIDQMSTFATYPQFVANEQKAGSLFEGMRLMRPLDQLPQTPQTTIKAT----GQFL 229 Query: 228 SLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIP 287 SL GLE L + LE L + + P+ +S + +GR+++ AD+V+ IP Sbjct: 230 SLETGLESLIERLEEVLERSEIRL--ETPLLAIS-REDGRYRLKTDHGPEYADYVLLTIP 286 Query: 288 ASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIV 347 + +LLP P L+ + +V ++ Q Q LP++G G +V + Sbjct: 287 HPQVVQLLPDAHLPELEQLTTHSTATVTMIFDQQQS--LPIEGTGFVVNRRAPYSITACT 344 Query: 348 YDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMP 407 + LR V G+ E S E+ QQ + G P Sbjct: 345 AIDQKWNHSAPDHTVLRAFVGRPGNDHLVHE------SDEVLQQAVLQDLEKICGRTLEP 398 Query: 408 SHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAA 467 ++ + +P YT+GH +++ R+ + A + LAG +Y+GV + DC+ S + Sbjct: 399 KQVIISRLMDGLPAYTVGHADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTMI 458 Query: 468 VSV 470 S+ Sbjct: 459 ESI 461 >1SEZ-A nrPDB Length = 504 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 130/516 (25%), Positives = 212/516 (41%), Gaps = 86/516 (16%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + V V+G G+SGLAA+Y L V + E+ + GG +RSV +G I++ G + Sbjct: 14 KRVAVIGAGVSGLAAAYKLKIHGL--NVTVFEAEGKAGGKLRSV-SQDGLIWDEGANTMT 70 Query: 63 PAGALGARTLLLVSELGLDSEVLPVRGDHPAAQN-RFLYVGGALHALPTGLRGLLRPS-- 119 + G T L+ DS L + P +QN R++ G LP+ L++ + Sbjct: 71 ESE--GDVTFLI------DSLGLREKQQFPLSQNKRYIARNGTPVLLPSNPIDLIKSNFL 122 Query: 120 ------PPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAG 173 +P+ W ++L++ + E+V F QR G EV +D G G Sbjct: 123 STGSKLQMLLEPILWKN-KKLSQV--SDSHESVSGFFQRHFGKEVVDYLIDPFVAGTCGG 179 Query: 174 NSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQ---WSLR 230 + LS+ FP L+ E+ S++LG + + A + Q +S Sbjct: 180 DPDSLSMHHSFPELWNLEKRFGSVILGAIRSKLSPKNEKKQGPPKTSANKKRQRGSFSFL 239 Query: 231 GGLEMLPQAL-------ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVI 283 GG++ L A+ E L SR VL C DS++++ +I Sbjct: 240 GGMQTLTDAICKDLREDELRLNSR---VLELSCSC-------------TEDSAIDSWSII 283 Query: 284 SAIPASVLSELLPAEA----APLARALSAITA------------------VSVAVVNLQY 321 SA P SE +A APL S A +SV + + Sbjct: 284 SASPHKRQSEEESFDAVIMTAPLCDVKSMKIAKRGNPFLLNFIPEVDYVPLSVVITTFKR 343 Query: 322 QGAHLPVQGFGHLVPSSEDP---GVLGIVYDSVAFPEQDGSPPGLRV-TVMLGGSWLQTL 377 + P++GFG LVPS E LG ++ S+ FP D +P + + T +GGS + L Sbjct: 344 ENVKYPLEGFGVLVPSKEQQHGLKTLGTLFSSMMFP--DRAPNNVYLYTTFVGGSRNREL 401 Query: 378 EASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLH-KNCIPQYTLGHWQKLESARQF 436 + +E+ ++ LG + P++ + HL+ P Y + L++ + Sbjct: 402 AKASRTELKEIVTSDLKQL----LGAEGEPTY-VNHLYWSKAFPLYGHNYDSVLDAIDKM 456 Query: 437 LTAHRLP-LTLAGASYEGVAVNDCIESGRQAAVSVL 471 LP L AG G++V + SG AA V+ Sbjct: 457 --EKNLPGLFYAGNHRGGLSVGKALSSGCNAADLVI 490 >2BXR-A nrPDB Length = 527 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 97/446 (21%), Positives = 174/446 (39%), Gaps = 81/446 (18%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 VVV+GGGISGL+A+ L+ V+++E+ +R+GG ++R + ++G + P Sbjct: 16 VVVIGGGISGLSAAKLLTEYGV--SVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPT 73 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK 124 R L L ELG+++ + V ++ YV G + RG PP Sbjct: 74 ---QNRILRLSKELGIETYKVNV------SERLVQYVKGKTYP----FRGAF---PPVWN 117 Query: 125 PLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCF 184 P+ + L + T+ + +G E+ + D+ A +++++ Sbjct: 118 PIAYLDYNNLWR--------TIDN-----MGKEIPT---DAPWEAQHADKWDKMTMKELI 161 Query: 185 PSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLR-------------G 231 + + R L + + P SAL W W ++ G Sbjct: 162 DKICWTKTARRFAYLFVNINVTSEPHEVSAL--------WFLWYVKQCGGTTRIFSVTNG 213 Query: 232 GLEML-----PQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAI 286 G E Q E + G V PV + ++ +L E +VI+AI Sbjct: 214 GQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAI 273 Query: 287 PASVLSEL-----LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGF-GHLVPSSED 340 P ++ +++ LPAE L + L + + Y+ A + + G ++ ED Sbjct: 274 PPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCM---MYYKEAFWKKKDYCGCMIIEDED 330 Query: 341 PGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQ 400 + + D+ + DGS P + G L L +E+ +++ E A Sbjct: 331 APISITLDDT----KPDGSLPAIM------GFILARKADRLAKLHKEIRKKKICELYAKV 380 Query: 401 LGLKEMPSHCLVHLHKN-CIPQYTLG 425 LG +E H + + KN C QY+ G Sbjct: 381 LGSQE-ALHPVHYEEKNWCEEQYSGG 405 >1O5W-A nrPDB Length = 534 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 106/449 (23%), Positives = 165/449 (36%), Gaps = 87/449 (19%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 VVV+GGGISGLAA+ LS V+++E+ +R+GG +VR + ++G + P Sbjct: 24 VVVIGGGISGLAAAKLLSEYKI--NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 81 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK 124 R L L ELG+++ + V + YV G + RG PP Sbjct: 82 ---QNRILRLSKELGIETYKVNVN------ERLVQYVKGKTYP----FRGAF---PPVWN 125 Query: 125 PLFWAGLRELTKPRGKEPDET-VHSFAQRRLGPEVASLAMDSLCRGV-FAGNSRELSIRS 182 PL + L + + E V + Q R E + M L + + +RE Sbjct: 126 PLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTARE----- 180 Query: 183 CFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLR------------ 230 F LF + + P SAL W W +R Sbjct: 181 -FAYLF------------VNINVTSEPHEVSAL--------WFLWYVRQCGGTARIFSVT 219 Query: 231 -GGLEML-----PQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVIS 284 GG E Q E + G V PV + + +L E +VIS Sbjct: 220 NGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVIS 279 Query: 285 AIPASVLSEL-----LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSE 339 AIP + +++ LP E L + L + V Y+ A + + + + Sbjct: 280 AIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVY---YKEAFWKKKDYCGCMIIED 336 Query: 340 DPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAAT 399 + + I D + DGS P + G L L +++ +++ E A Sbjct: 337 EEAPIAITLDDT---KPDGSLPAIM------GFILARKADRLAKLHKDIRKRKICELYAK 387 Query: 400 QLGLKE--MPSHCLVHLHKN-CIPQYTLG 425 LG +E P H + KN C QY+ G Sbjct: 388 VLGSQEALYPVH---YEEKNWCEEQYSGG 413 >1REO-A nrPDB Length = 486 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/57 (43%), Positives = 37/57 (64%), Gaps = 3/57 (5%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIF-ELGP 58 + VVV+G G+SGL+A+Y LS A +V ++E+SER GG +R+ R + LGP Sbjct: 34 KHVVVVGAGMSGLSAAYVLSGA--GHQVTVLEASERAGGRVRTYRNDKEDWYANLGP 88 >3KVE-A nrPDB Length = 486 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 27/60 (45%), Positives = 37/60 (61%), Gaps = 3/60 (5%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG-PNGAIFELGPRGI 61 + VVV+G G+SGL+A+Y L A KV ++E+SER GG +R+ R G LGP I Sbjct: 34 KHVVVVGAGMSGLSAAYVL--AGAGHKVTVLEASERAGGRVRTHRNSKEGWYANLGPMRI 91 >3RHA-A nrPDB Length = 482 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/82 (32%), Positives = 47/82 (57%), Gaps = 10/82 (12%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG--WIRSVRGPNGAIFELGP 58 + R VV++G G SGL A+ L +A V ++E+ +R+GG W ++ +GA+ E+G Sbjct: 6 LDRDVVIVGAGPSGLTAARELKKAGL--SVAVLEARDRVGGRTWTDTI---DGAMLEIGG 60 Query: 59 RGIRPAGALGARTLLLVSELGL 80 + + P + + L+ ELGL Sbjct: 61 QWVSPDQTV---LMELLDELGL 79 >3WE0-A nrPDB Length = 580 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 30/88 (34%), Positives = 47/88 (53%), Gaps = 10/88 (11%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRS--VRGPNGAIFELGPR 59 G V ++G GI+GL A+Y L + P +V + ++GG +RS G +G I ELG Sbjct: 65 GEEVAIVGAGIAGLVAAYELMKLGLKP---VVYEASKMGGRLRSQAFNGTDGIIAELG-- 119 Query: 60 GIR-PAGALGARTLLLVSELGLDSEVLP 86 G+R P + V +LGL+++ P Sbjct: 120 GMRFPVSSTA--FYHYVDKLGLETKPFP 145 >1F8S-A nrPDB Length = 498 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 3/57 (5%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIF-ELGP 58 + VV++G G++GL+A+Y L+ A +V ++E+SER GG +R+ R + LGP Sbjct: 34 KHVVIVGAGMAGLSAAYVLAGA--GHQVTVLEASERPGGRVRTYRNEEAGWYANLGP 88 >3BI4-A nrPDB Length = 516 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 35/55 (63%), Gaps = 1/55 (1%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELG 57 + V+++G GI+GL A+ L + +VL E+ +R+GG +++V G G +++G Sbjct: 9 KKVIIIGAGIAGLKAASTLHQNGIQDCLVL-EARDRVGGRLQTVTGYQGRKYDIG 62 >3NK2-X nrPDB Length = 431 Score = 35.4 bits (80), Expect = 0.061, Method: Compositional matrix adjust. Identities = 24/54 (44%), Positives = 32/54 (59%), Gaps = 4/54 (7%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG--WIRSVRGPNGAIFELG 57 +V+GGG SGL A+ L+ A KV+L+E ERLGG + R R G E+G Sbjct: 5 IVVGGGFSGLKAARDLTNA--GKKVLLLEGGERLGGRAYSRESRNVPGLRVEIG 56 >4IV9-A nrPDB Length = 557 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 8/64 (12%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFE-LGPRGIRP 63 V ++G GISGL A+ L RA VVL ES +R+GG + S +F+ PR I Sbjct: 41 VAIVGAGISGLVAATELLRAGV-KDVVLYESRDRIGGRVWS------QVFDQTRPRYIAE 93 Query: 64 AGAL 67 GA+ Sbjct: 94 MGAM 97 >5MOG-A nrPDB Length = 497 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 33/53 (62%), Gaps = 2/53 (3%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELG 57 VV+ G G++GL+ + +L+ A P +L+E+ + LGG I + + +G +E G Sbjct: 20 VVIAGAGLAGLSTAKYLADAGHKP--ILLEARDVLGGKIAAWKDEDGDWYETG 70 >2JB2-A nrPDB Length = 489 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 2/45 (4%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 +VVVLGGG +GL +++ L +A KV ++E+ R GG + + RG Sbjct: 13 SVVVLGGGPAGLCSAFELQKAGY--KVTVLEARTRPGGRVWTARG 55 >3ABT-A nrPDB Length = 662 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 28/46 (60%), Gaps = 2/46 (4%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPN 50 V+++G G+SGLAA+ L V L+E+ +R+GG + + R N Sbjct: 110 VIIIGSGVSGLAAARQLQSFGM--DVTLLEARDRVGGRVATFRKGN 153 >5L3D-A nrPDB Length = 852 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 28/46 (60%), Gaps = 2/46 (4%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPN 50 V+++G G+SGLAA+ L V L+E+ +R+GG + + R N Sbjct: 281 VIIIGSGVSGLAAARQLQSFGM--DVTLLEARDRVGGRVATFRKGN 324 >2VVL-G nrPDB Length = 495 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 20/55 (36%), Positives = 34/55 (61%), Gaps = 7/55 (12%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG--WIRSVRGPNGAIFELG 57 V+V+GGG GL A+ L+ A K +L+E+ +R+GG W ++ +G +E+G Sbjct: 42 VIVIGGGYCGLTATRDLTVAGF--KTLLLEARDRIGGRSWSSNI---DGYPYEMG 91 >4RXL-A nrPDB Length = 234 Score = 31.6 bits (70), Expect = 0.81, Method: Compositional matrix adjust. Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 5/74 (6%) Query: 222 ERWSQWSLRGGLEMLPQALETHLTSRGVSVLR--GQPVCGLSLQAEGRWKVSLRDSSLEA 279 E W+ + + GL + P + T L + + ++R QPV LQ W+ +L DS L Sbjct: 61 EEWANYLVEKGL-VKPNKVVT-LAANSLVLIRPTAQPVASFELQDAAAWQTALADSRLAV 118 Query: 280 DHVISAIPASVLSE 293 V A+PA + ++ Sbjct: 119 AQV-DAVPAGMYAK 131 >5L46-A nrPDB Length = 841 Score = 31.2 bits (69), Expect = 0.97, Method: Compositional matrix adjust. Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 1/37 (2%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 V++GGG G++ +YHL++A VVL+E SE G Sbjct: 25 TVIIGGGCVGVSLAYHLAKAGM-KDVVLLEKSELTAG 60 >5TWC-A nrPDB Length = 344 Score = 31.2 bits (69), Expect = 0.99, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 8/90 (8%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + V ++GGG SGL AS++ +++ V+S LGG +R P I+++G + Sbjct: 2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQS--ELGGKMRIY--PEKIIWDIGGIAPK 57 Query: 63 PAGALGART----LLLVSELGLDSEVLPVR 88 P + T L E+ L+ V+ +R Sbjct: 58 PCHEILKDTIKQGLYFKPEVHLNERVVDIR 87 >5ZYN-B nrPDB Length = 471 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/54 (40%), Positives = 33/54 (61%), Gaps = 4/54 (7%) Query: 1 MGRTVVVLGGGISGLAASYHL-SRAPCPPKVVLVESSERLGGW-IRSVRGPNGA 52 M + VVV+G G++GL S L S+ P VVL++ + +GG I++ G NGA Sbjct: 3 MKQPVVVIGSGLAGLTTSNRLISKYRIP--VVLLDKAASIGGNSIKASSGINGA 54 >3C8T-A nrPDB Length = 451 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/30 (50%), Positives = 18/30 (60%) Query: 110 TGLRGLLRPSPPFSKPLFWAGLRELTKPRG 139 TGL +LR P +KPL LR+LT PR Sbjct: 398 TGLFEVLRTMPEVAKPLGEEALRDLTDPRN 427 >4P9S-A nrPDB Length = 848 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 1/37 (2%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 V++GGG G++ +YHL++A VVL+E SE G Sbjct: 26 TVIIGGGCVGVSLAYHLAKAGM-RDVVLLEKSELTAG 61 >3GDN-A nrPDB Length = 521 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 11/64 (17%) Query: 61 IRPAGALGARTLLLVSELG----LDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLL 116 I AG +G LLL+S +G L S +PV HP YVG LH P +L Sbjct: 254 IVSAGTIGTPQLLLLSGVGPESYLSSLNIPVVLSHP-------YVGQFLHDNPRNFINIL 306 Query: 117 RPSP 120 P+P Sbjct: 307 PPNP 310 >4DGK-A nrPDB Length = 501 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 3/85 (3%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + V+G G GLA + L A P V+L+E ++ GG V G F+ GP I Sbjct: 2 KPTTVIGAGFGGLALAIRLQAAGIP--VLLLEQRDKPGGRA-YVYEDQGFTFDAGPTVIT 58 Query: 63 PAGALGARTLLLVSELGLDSEVLPV 87 A+ L +L E+LPV Sbjct: 59 DPSAIEELFALAGKQLKEYVELLPV 83 >3FPZ-A nrPDB Length = 326 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 25/37 (67%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 V+++G G SGL+A+Y +++ KV ++ESS GG Sbjct: 68 VIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGG 104 >3RED-A nrPDB Length = 521 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 24/64 (37%), Positives = 31/64 (48%), Gaps = 11/64 (17%) Query: 61 IRPAGALGARTLLLVSELG----LDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLL 116 I AG +G+ LLL+S +G L S +PV HP YVG LH P +L Sbjct: 255 IVSAGPIGSPQLLLLSGVGPESYLSSLNIPVVLSHP-------YVGQFLHDNPRNFINIL 307 Query: 117 RPSP 120 P+P Sbjct: 308 PPNP 311 >2BK5-A nrPDB Length = 520 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 20/106 (18%) Query: 11 GISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGAR 70 GISG+AA+ L + VV++E+ +R+GG ++R +LG + P R Sbjct: 13 GISGMAAAKLLHDSGL--NVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPT---QNR 67 Query: 71 TLLLVSELGLDS---------------EVLPVRGDHPAAQNRFLYV 101 L L ELGL++ + P RG P N Y+ Sbjct: 68 ILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYL 113 >3UKH-A nrPDB Length = 519 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 17/53 (32%), Positives = 32/53 (60%), Gaps = 1/53 (1%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELG 57 V+V+G G +GL A+ L++ P ++V+S+E GG + P G ++++G Sbjct: 9 VLVIGAGPTGLGAAKRLNQIDG-PSWMIVDSNETPGGLASTDVTPEGFLYDVG 60 >1RP0-A nrPDB Length = 284 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 16/37 (43%), Positives = 25/37 (67%), Gaps = 1/37 (2%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 VVV+G G +GL+A+Y +S+ P +V ++E S GG Sbjct: 42 VVVVGAGSAGLSAAYEISKNP-NVQVAIIEQSVSPGG 77 >5TUL-A nrPDB Length = 406 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 24/46 (52%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 + ++V+G I+G A Y L+ P +V S R GG+ +RG Sbjct: 26 KKILVIGASIAGPALCYWLNHYGFQPTLVEKNQSTRKGGYAIDLRG 71 >3L1R-A nrPDB Length = 478 Score = 29.3 bits (64), Expect = 4.0, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 28/41 (68%), Gaps = 1/41 (2%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 +G V+V+G G+SG++A+ LS A ++L E+++ +GG Sbjct: 3 VGPRVIVVGAGMSGISAAKRLSEAGITDLLIL-EATDHIGG 42 >3ATQ-A nrPDB Length = 453 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 26/38 (68%), Gaps = 4/38 (10%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESS--ERLG 40 V+++GGG +G +A+Y LSR K++LV+S R+G Sbjct: 9 VLIIGGGFAGSSAAYQLSRRGL--KILLVDSKPWNRIG 44 >5TUM-A nrPDB Length = 410 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 24/44 (54%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 ++V+G G++G A Y L R P ++ +S R GG VRG Sbjct: 28 ILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVRG 71 >4ZZQ-A nrPDB Length = 438 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 15/34 (44%) Query: 24 APCPPKVVLVESSERLGGWIRSVRGPNGAIFELG 57 A CP + + S + GWI S PN LG Sbjct: 173 AQCPRDLKFISGSANVDGWIPSTNNPNTGYGNLG 206 >4FWE-A nrPDB Length = 796 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 49/113 (43%), Gaps = 9/113 (7%) Query: 246 SRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLS----ELLPAEAAP 301 + G+ + PV + + + + A V+ +P ++L + P + Sbjct: 561 AEGLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEK 620 Query: 302 LARALSAITAVSVAVVNLQ--YQGAHLPVQG---FGHLVPSSEDPGVLGIVYD 349 +A++++ A + + LQ Y+ VQG FGH+ PS+ G+ + YD Sbjct: 621 KMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYD 673 >4C5O-A nrPDB Length = 357 Score = 28.1 bits (61), Expect = 8.2, Method: Compositional matrix adjust. Identities = 15/32 (46%), Positives = 21/32 (65%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESS 36 VVV+GGG SGL+A Y L R+ ++ E+S Sbjct: 6 VVVIGGGQSGLSAGYFLRRSGLSYVILDAEAS 37 >5ZBC-A nrPDB Length = 451 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 2/56 (3%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVL--VESSERLGGWIRSVRGPNGAIFELG 57 + ++G GISGL + HL +P + L + + GG IRS A ELG Sbjct: 26 DICIVGAGISGLTCASHLLDSPACRGLSLRIFDMQQEAGGRIRSKMLDGKASIELG 81 >5TUF-A nrPDB Length = 409 Score = 27.7 bits (60), Expect = 10.0, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 25/44 (56%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 ++V+G G++G A +Y L R P ++ ++ R GG +RG Sbjct: 28 ILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRG 71 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4IVM-B nrPDB 608 e-174 3I6D-A nrPDB 432 e-121 3LOV-A nrPDB 428 e-120 1SEZ-A nrPDB 384 e-107 2IVE-A nrPDB 364 e-101 1O5W-A nrPDB 354 4e-98 2BXR-A nrPDB 353 9e-98 1REO-A nrPDB 96 3e-20 3KVE-A nrPDB 94 1e-19 Sequences not found previously or not previously below threshold: 2BK5-A nrPDB 259 3e-69 3RHA-A nrPDB 92 4e-19 1F8S-A nrPDB 90 2e-18 5MOG-A nrPDB 74 2e-13 3L1R-A nrPDB 66 3e-11 2JB2-A nrPDB 66 4e-11 4DGK-A nrPDB 64 1e-10 3WE0-A nrPDB 63 3e-10 4IV9-A nrPDB 60 3e-09 3ABT-A nrPDB 59 4e-09 3NK2-X nrPDB 57 2e-08 5L3D-A nrPDB 56 2e-08 5ZBC-A nrPDB 56 5e-08 3BI4-A nrPDB 53 2e-07 4FWE-A nrPDB 52 4e-07 3X0V-A nrPDB 52 5e-07 6CR0-A nrPDB 51 1e-06 2VVL-G nrPDB 49 5e-06 4REP-A nrPDB 48 9e-06 5Z70-A nrPDB 46 4e-05 4ZCC-A nrPDB 43 2e-04 3UKH-A nrPDB 43 3e-04 3KKJ-A nrPDB 42 6e-04 3FPZ-A nrPDB 41 8e-04 4UIR-A nrPDB 41 0.001 5TWC-A nrPDB 41 0.002 3JSK-A nrPDB 40 0.003 3LXD-A nrPDB 39 0.004 3T14-A nrPDB 38 0.007 5NMX-A nrPDB 38 0.008 5GSN-A nrPDB 38 0.011 3QJ4-A nrPDB 38 0.013 4C5O-A nrPDB 38 0.014 3K30-A nrPDB 37 0.017 1PS9-A nrPDB 37 0.018 2GAG-B nrPDB 37 0.022 5L46-A nrPDB 36 0.028 3UP5-A nrPDB 36 0.030 4P9S-A nrPDB 36 0.035 1RP0-A nrPDB 35 0.054 1FL2-A nrPDB 35 0.057 4YKF-A nrPDB 35 0.059 4IA5-A nrPDB 35 0.061 4EMJ-A nrPDB 35 0.075 5TUF-A nrPDB 35 0.090 4OVI-A nrPDB 34 0.097 4Z44-A nrPDB 34 0.12 2GV8-A nrPDB 34 0.14 6GAR-A nrPDB 34 0.15 5TUM-A nrPDB 34 0.16 3ATQ-A nrPDB 34 0.16 5JFC-L nrPDB 33 0.25 5VJ7-A nrPDB 33 0.25 3R9U-A nrPDB 33 0.29 6HNS-A nrPDB 33 0.30 4YNU-A nrPDB 33 0.34 5TUL-A nrPDB 32 0.49 2VOU-A nrPDB 32 0.53 5EZ7-A nrPDB 32 0.54 4Y4N-A nrPDB 32 0.58 5TUK-A nrPDB 32 0.63 6GAS-A nrPDB 32 0.64 2LDB-A nrPDB 32 0.64 2CVJ-A nrPDB 32 0.64 1V59-A nrPDB 32 0.68 3FG2-P nrPDB 32 0.70 5ZBB-A nrPDB 32 0.71 4AP1-A nrPDB 32 0.71 3IP1-A nrPDB 31 0.83 6DLL-A nrPDB 31 0.99 4Y4M-A nrPDB 31 1.2 3RP7-A nrPDB 31 1.4 5EVY-X nrPDB 30 1.9 5XHU-A nrPDB 30 2.0 2RGJ-A nrPDB 30 2.1 1C0L-A nrPDB 30 2.3 1DOD-A nrPDB 30 2.3 2QAE-A nrPDB 30 2.6 5JS6-A nrPDB 29 3.2 >4IVM-B nrPDB Length = 483 Score = 608 bits (1566), Expect = e-174, Method: Composition-based stats. Identities = 476/477 (99%), Positives = 476/477 (99%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGP G Sbjct: 7 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPGG 66 Query: 61 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP 120 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP Sbjct: 67 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP 126 Query: 121 PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI 180 PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI Sbjct: 127 PFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSI 186 Query: 181 RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL 240 RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL Sbjct: 187 RSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQAL 246 Query: 241 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA 300 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA Sbjct: 247 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAA 306 Query: 301 PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP 360 PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP Sbjct: 307 PLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSP 366 Query: 361 PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP 420 PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP Sbjct: 367 PGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIP 426 Query: 421 QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS 477 QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS Sbjct: 427 QYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS 483 >3I6D-A nrPDB Length = 470 Score = 432 bits (1111), Expect = e-121, Method: Composition-based stats. Identities = 127/487 (26%), Positives = 222/487 (45%), Gaps = 45/487 (9%) Query: 3 RTVVVLGGGISGLAASYHLSR----APCPPKVVLVESSERLGGWIRSVRGPNGAIFELGP 58 + VV++GGGI+GLAA++++ + P ++ LVE+S R+GG I++V+ +G I E GP Sbjct: 6 KHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQTVK-KDGYIIERGP 64 Query: 59 RGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTG-LRGLLR 117 + LV +LGL+ ++ A ++ V LH +P G + G+ Sbjct: 65 DSFLERKKSAPQ---LVKDLGLEHLLVN-----NATGQSYVLVNRTLHPMPKGAVMGIPT 116 Query: 118 PSPPF-------SKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGV 170 PF A + + + D+++ F +RR+G EV ++ L G+ Sbjct: 117 KIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRVGDEVVENLIEPLLSGI 176 Query: 171 FAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLR 230 +AG+ +LS+ S FP +Q EQ HRS++LG+ + +P + + ++ +L Sbjct: 177 YAGDIDKLSLMSTFPQFYQTEQKHRSLILGM-----KKTRPQGSGQQLTAKKQGQFQTLS 231 Query: 231 GGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDS-SLEADHVISAIPAS 289 GL+ L + +E L + V +G V LS + + + L + +L+AD VI P Sbjct: 232 TGLQTLVEEIEKQL--KLTKVYKGTKVTKLS-HSGSCYSLELDNGVTLDADSVIVTAPHK 288 Query: 290 VLSELLPAEAAPLARALSAITAVSVAVVNLQYQGA--HLPVQGFGHLVPSSEDPGVLGIV 347 + +L P L + + SVA V L + + +G G ++ + D + Sbjct: 289 AAAGMLS--ELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVISRNSDFAITACT 346 Query: 348 YDSVAFPEQDGSPPG---LRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLK 404 + + +P +P G LR V G + S LS E + + Sbjct: 347 WTNKKWPH--AAPEGKTLLRAYVGKAG------DESIVDLSDNDIINIVLEDLKKVMNIN 398 Query: 405 EMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGR 464 P V +PQY +GH Q+++ R+ L + + + GAS+EGV + DCI+ G+ Sbjct: 399 GEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGIPDCIDQGK 458 Query: 465 QAAVSVL 471 A L Sbjct: 459 AAVSDAL 465 >3LOV-A nrPDB Length = 475 Score = 428 bits (1100), Expect = e-120, Method: Composition-based stats. Identities = 118/483 (24%), Positives = 204/483 (42%), Gaps = 41/483 (8%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + +V++GGGI+GLAA+Y+ RA + L+E+ ERLGG + + R +G E GP Sbjct: 5 KRLVIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGGKVATYR-EDGFTIERGPDSY- 62 Query: 63 PAGALGARTLL--LVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGL-------R 113 + + +L L+ +GL +++ F+ G LH +P G Sbjct: 63 ----VARKHILTDLIEAIGLGEKLVR-----NNTSQAFILDTGGLHPIPKGAVMGIPTDL 113 Query: 114 GLLRPSPPFSKPLFWAGLRELTKP----RGKEPDETVHSFAQRRLGPEVASLAMDSLCRG 169 L R + ++ L P R E D + + + RLG + ++ L G Sbjct: 114 DLFRQTTLLTEEEKQEVADLLLHPSDSLRIPEQDIPLGEYLRPRLGDALVEKLIEPLLSG 173 Query: 170 VFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGA--GRTPQPDSALIRQALAERWSQW 227 ++AGN ++S + +P EQ S+ G+ L + PQ I+ Sbjct: 174 IYAGNIDQMSTFATYPQFVANEQKAGSLFEGMRLMRPLDQLPQTPQTTIKAT----GQFL 229 Query: 228 SLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIP 287 SL GLE L + LE L + + P+ +S + +GR+++ AD+V+ IP Sbjct: 230 SLETGLESLIERLEEVLERSEIRL--ETPLLAISRE-DGRYRLKTDHGPEYADYVLLTIP 286 Query: 288 ASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIV 347 + +LLP P L+ + +V ++ Q Q LP++G G +V + Sbjct: 287 HPQVVQLLPDAHLPELEQLTTHSTATVTMIFDQQQS--LPIEGTGFVVNRRAPYSITACT 344 Query: 348 YDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMP 407 + LR V G+ E S E+ QQ + G P Sbjct: 345 AIDQKWNHSAPDHTVLRAFVGRPGNDHLVHE------SDEVLQQAVLQDLEKICGRTLEP 398 Query: 408 SHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAA 467 ++ + +P YT+GH +++ R+ + A + LAG +Y+GV + DC+ S + Sbjct: 399 KQVIISRLMDGLPAYTVGHADRIQRVREEVLAQYPGIYLAGLAYDGVGLPDCVASAKTMI 458 Query: 468 VSV 470 S+ Sbjct: 459 ESI 461 >1SEZ-A nrPDB Length = 504 Score = 384 bits (985), Expect = e-107, Method: Composition-based stats. Identities = 121/508 (23%), Positives = 201/508 (39%), Gaps = 68/508 (13%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGI 61 + V V+G G+SGLAA+Y L V + E+ + GG +RSV +G I++ G + Sbjct: 13 AKRVAVIGAGVSGLAAAYKLKIHGL--NVTVFEAEGKAGGKLRSV-SQDGLIWDEGANTM 69 Query: 62 RPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQN-RFLYVGGALHALPTGLRGLLRPS- 119 + G T L +DS L + P +QN R++ G LP+ L++ + Sbjct: 70 TESE--GDVTFL------IDSLGLREKQQFPLSQNKRYIARNGTPVLLPSNPIDLIKSNF 121 Query: 120 -------PPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFA 172 +P+ W + + + E+V F QR G EV +D G Sbjct: 122 LSTGSKLQMLLEPILWKNKKL---SQVSDSHESVSGFFQRHFGKEVVDYLIDPFVAGTCG 178 Query: 173 GNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQ---WSL 229 G+ LS+ FP L+ E+ S++LG + + A + Q +S Sbjct: 179 GDPDSLSMHHSFPELWNLEKRFGSVILGAIRSKLSPKNEKKQGPPKTSANKKRQRGSFSF 238 Query: 230 RGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPAS 289 GG++ L A+ R + V LS DS++++ +ISA P Sbjct: 239 LGGMQTLTDAICK--DLREDELRLNSRVLELSCSC-------TEDSAIDSWSIISASPHK 289 Query: 290 VLSELLPAEA----APLARALSAITA------------------VSVAVVNLQYQGAHLP 327 SE +A APL S A +SV + + + P Sbjct: 290 RQSEEESFDAVIMTAPLCDVKSMKIAKRGNPFLLNFIPEVDYVPLSVVITTFKRENVKYP 349 Query: 328 VQGFGHLVPSSEDP---GVLGIVYDSVAFPEQDGSPPGLRVT-VMLGGSWLQTLEASGCV 383 ++GFG LVPS E LG ++ S+ FP D +P + + +GGS + L + Sbjct: 350 LEGFGVLVPSKEQQHGLKTLGTLFSSMMFP--DRAPNNVYLYTTFVGGSRNRELAKASRT 407 Query: 384 LSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLP 443 +E+ ++ LG + P++ P Y + L++ + + Sbjct: 408 ELKEIVTSDLKQL----LGAEGEPTYVNHLYWSKAFPLYGHNYDSVLDAIDKM-EKNLPG 462 Query: 444 LTLAGASYEGVAVNDCIESGRQAAVSVL 471 L AG G++V + SG AA V+ Sbjct: 463 LFYAGNHRGGLSVGKALSSGCNAADLVI 490 >2IVE-A nrPDB Length = 478 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 146/479 (30%), Positives = 226/479 (47%), Gaps = 31/479 (6%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGI 61 G V V+GGGISGLA ++HL VL+ESS RLGG + + G + E GP Sbjct: 16 GMNVAVVGGGISGLAVAHHLRSRGT--DAVLLESSARLGGAVGT-HALAGYLVEQGPNSF 72 Query: 62 RPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSP- 120 T L + L L+ +R PAA+ R++Y G L ++P L Sbjct: 73 LDRE---PATRALAAALNLEG---RIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDIL 126 Query: 121 PFSKPLFWAGLRELTKPRGKEP-DETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELS 179 P L AG EL R E DE++ +F +R LG + +D++ G++AG+ +LS Sbjct: 127 PLGARLRVAG--ELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDVEQLS 184 Query: 180 IRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAE-RWSQWSLRGGLEMLPQ 238 + + FP L + E+ HRS++LG + + Q +AL + + + GGL++L Sbjct: 185 VAATFPMLVKMEREHRSLILGAI--RAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLID 242 Query: 239 ALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSL----RDSSLEADHVISAIPASVLSEL 294 AL L G + G V GL+ + +G W++ + R + L V+ A PA ++L Sbjct: 243 ALAASL---GDAAHVGARVEGLA-REDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKL 298 Query: 295 LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAF 353 L LA ++ I +AVV+L + LP GFG LVP+ E +LG ++ S F Sbjct: 299 LRPLDDALAALVAGIAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQRRMLGAIHASTTF 358 Query: 354 PEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVH 413 P + L + M+GG+ L ++ A+E G+ PS V Sbjct: 359 PFRAEGGRVLY-SCMVGGARQPGLVEQ----DEDALAALAREELKALAGVTARPSFTRVF 413 Query: 414 LHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLG 472 IPQY LGH +++ + L L L G +Y+GV +NDCI + Q A +++ Sbjct: 414 RWPLGIPQYNLGHLERVAAIDAAL-QRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVA 471 >1O5W-A nrPDB Length = 534 Score = 354 bits (908), Expect = 4e-98, Method: Composition-based stats. Identities = 97/446 (21%), Positives = 160/446 (35%), Gaps = 81/446 (18%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 VVV+GGGISGLAA+ LS V+++E+ +R+GG +VR + ++G + P Sbjct: 24 VVVIGGGISGLAAAKLLSEYKI--NVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPT 81 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK 124 R L L ELG+++ + V + YV G + RG PP Sbjct: 82 ---QNRILRLSKELGIETYKVNVN------ERLVQYVKGKTYP----FRGAF---PPVWN 125 Query: 125 PLFWAGLRELTKPRGKEPDE-TVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSC 183 PL + L + + E V + Q R E +++++ Sbjct: 126 PLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQE-----------------WDKMTMKDL 168 Query: 184 FPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLR------------- 230 + + L + + P SAL W W +R Sbjct: 169 IDKICWTKTAREFAYLFVNINVTSEPHEVSAL--------WFLWYVRQCGGTARIFSVTN 220 Query: 231 GGLEML-----PQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISA 285 GG E Q E + G V PV + + +L E +VISA Sbjct: 221 GGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISA 280 Query: 286 IPASVLSEL-----LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSED 340 IP + +++ LP E L + L + V Y+ A + + + ++ Sbjct: 281 IPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVY---YKEAFWKKKDYCGCMIIEDE 337 Query: 341 PGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQ 400 + I D DGS P + G L L +++ +++ E A Sbjct: 338 EAPIAITLDDTK---PDGSLPAIM------GFILARKADRLAKLHKDIRKRKICELYAKV 388 Query: 401 LGLKEMPSHCLVHLHKN-CIPQYTLG 425 LG + + + + KN C QY+ G Sbjct: 389 LGSQ-EALYPVHYEEKNWCEEQYSGG 413 >2BXR-A nrPDB Length = 527 Score = 353 bits (906), Expect = 9e-98, Method: Composition-based stats. Identities = 93/445 (20%), Positives = 166/445 (37%), Gaps = 79/445 (17%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 VVV+GGGISGL+A+ L+ V+++E+ +R+GG ++R + ++G + P Sbjct: 16 VVVIGGGISGLSAAKLLTEYGV--SVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPT 73 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK 124 R L L ELG+++ + V ++ YV G + RG PP Sbjct: 74 ---QNRILRLSKELGIETYKVNV------SERLVQYVKGKTYP----FRGAF---PPVWN 117 Query: 125 PLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCF 184 P+ + L + +G E+ + D+ A +++++ Sbjct: 118 PIAYLDYNNLWRTID-------------NMGKEIPT---DAPWEAQHADKWDKMTMKELI 161 Query: 185 PSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLR-------------G 231 + + R L + + P SAL W W ++ G Sbjct: 162 DKICWTKTARRFAYLFVNINVTSEPHEVSAL--------WFLWYVKQCGGTTRIFSVTNG 213 Query: 232 GLEML-----PQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAI 286 G E Q E + G V PV + ++ +L E +VI+AI Sbjct: 214 GQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAI 273 Query: 287 PASVLSEL-----LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDP 341 P ++ +++ LPAE L + L + + Y+ A + + + ++ Sbjct: 274 PPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMY---YKEAFWKKKDYCGCMIIEDED 330 Query: 342 GVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQL 401 + I D DGS P + G L L +E+ +++ E A L Sbjct: 331 APISITLDDTK---PDGSLPAIM------GFILARKADRLAKLHKEIRKKKICELYAKVL 381 Query: 402 GLKEMPSHCLVHLHKN-CIPQYTLG 425 G + H + + KN C QY+ G Sbjct: 382 GSQ-EALHPVHYEEKNWCEEQYSGG 405 >2BK5-A nrPDB Length = 520 Score = 259 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 84/430 (19%), Positives = 144/430 (33%), Gaps = 63/430 (14%) Query: 12 ISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGART 71 ISG+AA+ L VV++E+ +R+GG ++R +LG + P R Sbjct: 14 ISGMAAAKLL--HDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPT---QNRI 68 Query: 72 LLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGL 131 L L ELGL++ + + +V G + RG PP P+ + Sbjct: 69 LRLAKELGLETYKVNE------VERLIHHVKGKSYP----FRGPF---PPVWNPITYLDH 115 Query: 132 RELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAE 191 + +G E+ S D+ + A ++++ L E Sbjct: 116 NNFWRTMDD-------------MGREIPS---DAPWKAPLAEEWDNMTMKELLDKLCWTE 159 Query: 192 QTHRSILLGLLLGAGRTPQPDSAL-----IRQALAERWSQWSLRGGLEML-----PQALE 241 + L + L SAL ++Q + GG E Q E Sbjct: 160 SAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIFSTTNGGQERKFVGGSGQVSE 219 Query: 242 THLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSEL-----LP 296 + G V +PV + E +L EA +VISAIP ++ ++ LP Sbjct: 220 RIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLP 279 Query: 297 AEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQ 356 + + + + V Y+ + + + + + D Sbjct: 280 MMRNQMITRVPLGSVIKCIVY---YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTK---- 332 Query: 357 DGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHK 416 P G +M G L L++E ++ E A LG + + K Sbjct: 333 ---PEGNYAAIM--GFILAHKARKLARLTKEERLKKLCELYAKVLGS-LEALEPVHYEEK 386 Query: 417 N-CIPQYTLG 425 N C QY+ G Sbjct: 387 NWCEEQYSGG 396 >1REO-A nrPDB Length = 486 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 65/344 (18%), Positives = 112/344 (32%), Gaps = 53/344 (15%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIF-ELGPRGI 61 + VVV+G G+SGL+A+Y LS A +V ++E+SER GG +R+ R + LGP + Sbjct: 34 KHVVVVGAGMSGLSAAYVLSGAG--HQVTVLEASERAGGRVRTYRNDKEDWYANLGPMRL 91 Query: 62 RPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPP 121 + + + GL L F+ G+L+ Sbjct: 92 PEKHRIVREYIR---KFGLQ---LNEFSQENDNAWYFIKNIRKRVGEVKKDPGVLK---- 141 Query: 122 FSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIR 181 + E ++ + LG ++ L R + + Sbjct: 142 -------------YPVKPSEEGKSAGQLYEESLGK-----VVEELKRTNCSYILNKYDTY 183 Query: 182 SCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALI---------RQALAERWSQWSLRGG 232 S L ++ G + G DS A + GG Sbjct: 184 STKEYLL----KEGNLSPGAVDMIGDLMNEDSGYYVSFPESLRHDDIFAYEKRFDEIVGG 239 Query: 233 LEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKV----SLRDSSLEADHVIS--AI 286 ++ LP ++ + V V + AE V + +S+ AD+VI Sbjct: 240 MDKLPTSMYRAIE---EKVHLNAQVIKIQKNAEKVTVVYQTPAKEMASVTADYVIVCTTS 296 Query: 287 PASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQG 330 A+ + P A AL ++ S + L +G Sbjct: 297 RATRRIKFEPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDEG 340 >3KVE-A nrPDB Length = 486 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 65/344 (18%), Positives = 104/344 (30%), Gaps = 53/344 (15%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG-PNGAIFELGPRGI 61 + VVV+G G+SGL+A+Y L A KV ++E+SER GG +R+ R G LGP I Sbjct: 34 KHVVVVGAGMSGLSAAYVL--AGAGHKVTVLEASERAGGRVRTHRNSKEGWYANLGPMRI 91 Query: 62 RPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPP 121 + + L + N + ++ G + P Sbjct: 92 PEKHRIVREYIR--------KFGLNLNEFSQENDNAWYFIKNI-----RKRVGEVNKDPG 138 Query: 122 FSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIR 181 K + E ++ + LG V L R + + Sbjct: 139 LLK----------YPVKPSEEGKSAGQLYEESLGSAV-----KDLKRTNCSYILNKYDTY 183 Query: 182 SCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALI---------RQALAERWSQWSLRGG 232 S L ++ G + G DS A + GG Sbjct: 184 STKEYLI----KEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGG 239 Query: 233 LEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKV----SLRDSSLEADHVIS--AI 286 ++ LP ++ + V V + A SS AD+VI Sbjct: 240 MDQLPTSMYRAIE---EKVKFNARVIKIQQNANQVTVTYQTPEKDTSSNTADYVIVCTTS 296 Query: 287 PASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQG 330 A+ + P AL ++ S + L G Sbjct: 297 RAARRIQFEPPLPPKKQHALRSVHYRSGTKIFLTCSSKFWEDDG 340 >3RHA-A nrPDB Length = 482 Score = 92.3 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 82/419 (19%), Positives = 140/419 (33%), Gaps = 63/419 (15%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 + R VV++G G SGL A+ L +A V ++E+ +R+GG + +GA+ E+G + Sbjct: 6 LDRDVVIVGAGPSGLTAARELKKAGL--SVAVLEARDRVGGRTWT-DTIDGAMLEIGGQW 62 Query: 61 IRPAGALGARTLLLVSELGLDSEVLPVRGDH---PAAQNRFLYVGGALHALPTGLRGLLR 117 + P + L+ ELGL G+ A R Y G + + + Sbjct: 63 VSP---DQTVLMELLDELGLKMYSRYRDGESVYIGADGKRTQYT-GDTFPVNETTKAEMD 118 Query: 118 PSPPFSKPLFWA-GLRELT-KPRGKEPD-ETVHSFAQRRLGPEVASLAMDSLCRGVFAGN 174 L G E P+ +E D + H + ++ E A + G Sbjct: 119 KLVAILDELAAEIGPTEPWAHPKARELDTISFHHWLRQNSNDEEACNNIGLFIAGG---- 174 Query: 175 SRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLE 234 + H L +L A + + + GG++ Sbjct: 175 -------------MLTKPAHAFSALQAVLMAASA----GSFSHLTDEDFILDKRVIGGMQ 217 Query: 235 MLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSEL 294 Q G V+ PV + E V +++ A VI A+P ++ S + Sbjct: 218 ---QVSLLQAAELGDDVVLNSPVRTIKW-DENGVSVVSERATVNARFVIMAVPPNLYSRV 273 Query: 295 -----LPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQ---GFGHLVPSSEDPGVLGI 346 LP + + S + V V Y + G G ++ Sbjct: 274 SFDPPLPRRQHQMHQHQSLGLVIKVHAV---YDTPFWREEGLSGTGF-----SAGALVQE 325 Query: 347 VYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKE 405 VYD+ + G+ L G + LS E ++ E+ A LG K Sbjct: 326 VYDNTNHGDSRGT---------LVGFVSDEKADAVFELSAEDRKKAILESIAGFLGDKA 375 >1F8S-A nrPDB Length = 498 Score = 90.4 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 105/344 (30%), Gaps = 53/344 (15%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPN-GAIFELGPRGI 61 + VV++G G++GL+A+Y L A +V ++E+SER GG +R+ R G LGP + Sbjct: 34 KHVVIVGAGMAGLSAAYVL--AGAGHQVTVLEASERPGGRVRTYRNEEAGWYANLGPMRL 91 Query: 62 RPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPP 121 + ++ + L F+ GLL+ Sbjct: 92 PE------KHRIVREYIRKFDLRLNEFSQENDNAWYFIKNIRKKVGEVKKDPGLLK---- 141 Query: 122 FSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIR 181 + E ++ + LG ++ L R + + Sbjct: 142 -------------YPVKPSEAGKSAGQLYEESLGK-----VVEELKRTNCSYILNKYDTY 183 Query: 182 SCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALI---------RQALAERWSQWSLRGG 232 S L + G + G DS A + G Sbjct: 184 STKEYLI----KEGDLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVDG 239 Query: 233 LEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWK----VSLRDSSLEADHVIS--AI 286 ++ LP A+ + V V + + +S S+ AD+VI Sbjct: 240 MDKLPTAMYRDIQ---DKVHFNAQVIKIQQNDQKVTVVYETLSKETPSVTADYVIVCTTS 296 Query: 287 PASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQG 330 A L + P A AL ++ S + L G Sbjct: 297 RAVRLIKFNPPLLPKKAHALRSVHYRSGTKIFLTCTTKFWEDDG 340 >5MOG-A nrPDB Length = 497 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 65/339 (19%), Positives = 125/339 (36%), Gaps = 53/339 (15%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRP 63 VV+ G G++GL+ + +L+ A K +L+E+ + LGG I + + +G +E G Sbjct: 19 QVVIAGAGLAGLSTAKYLADAG--HKPILLEARDVLGGKIAAWKDEDGDWYETGLHIFFG 76 Query: 64 AGALGARTLLLVSELGL-------DSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLL 116 A L ELG+ + ++ + P +RF + L G+ +L Sbjct: 77 AY---PNIQNLFGELGINDRLQWKEHSMIFAMPNKPGEFSRFDFPETLPAPL-NGIWAIL 132 Query: 117 RPSPPFSKPLFWAGLRELTKPR-------GKEPDETVHSFAQRR-LGPEVASLAMDSLCR 168 R + + P L + TV + +++ + V ++ + Sbjct: 133 RNNEMLTWPEKVKFALGLLPAMVGGQAYVEAQDGFTVSEWMKKQGVPDRVNDEVFIAMSK 192 Query: 169 GVFAGNSRELSIRSCFPSLFQ-AEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQW 227 + N ELS++ +L + ++ H S + L G P Sbjct: 193 ALNFINPDELSMQCILIALNRFLQEKHGSKMAFLD---GNPP------------------ 231 Query: 228 SLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWK--VSLRDSSLEADHVISA 285 E L + H+ S G V + + L +G K + + D + A Sbjct: 232 ------ERLCMPIVDHVRSLGGEVRLNSRIQKIELNPDGTVKHFALTDGTQITGDAYVFA 285 Query: 286 IPASVLSELLPAEAAPLA--RALSAITAVSVAVVNLQYQ 322 P +L L+P E ++ + L + V V V++ + Sbjct: 286 TPVDILKLLVPQEWKEISYFKKLEKLVGVPVINVHIWFD 324 >3L1R-A nrPDB Length = 478 Score = 66.5 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 73/423 (17%), Positives = 134/423 (31%), Gaps = 40/423 (9%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 +G V+V+G G+SG++A+ LS A ++++E+++ +GG + G ELG Sbjct: 3 VGPRVIVVGAGMSGISAAKRLSEAGIT-DLLILEATDHIGGRMHKT-NFAGINVELGANW 60 Query: 61 IRPAGALGARTLLLVSELGLDSEVLPVRGDHP-AAQNRFLYVGGALHALPTGLRGLLRPS 119 + G G + + + ++ R D AQN + GG + Sbjct: 61 VE--GVNGGKMNPIWPIVNSTLKLRNFRSDFDYLAQNVYKEDGG------------VYDE 106 Query: 120 PPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELS 179 K + A E G++ T+H+ + + + G A + Sbjct: 107 DYVQKRIELADSVE---EMGEKLSATLHASGRDDMSILAMQRLNEHQPNGP-ATPVDMVV 162 Query: 180 IRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQA 239 F F S+ + L D + + L G Sbjct: 163 DYYKFDYEFAEPPRVTSLQNTVPLATFSDFGDDVYFVADQRGYEAVVYYLAGQYLKTDDK 222 Query: 240 LETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASV----LSELL 295 + R + + V + G + +S AD+V+ + V L + Sbjct: 223 SGKIVDPR---LQLNKVVREIKYSPGGVTVKTEDNSVYSADYVMVSASLGVLQSDLIQFK 279 Query: 296 PAEAAPLARALSAITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFP 354 P RA+ ++ L++ P +G + +S G G+ F Sbjct: 280 PKLPTWKVRAIYQFDMAVYTMIFLKFPRKFWPEGKGREFFLYASSRRGYYGVW---QEFE 336 Query: 355 EQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHC--LV 412 +Q L VTV S S E + + K++P LV Sbjct: 337 KQYPDANVLLVTVTDEESR------RIEQQSDEQTKAEIMQVLRKMFPGKDVPDATDILV 390 Query: 413 HLH 415 Sbjct: 391 PRW 393 >2JB2-A nrPDB Length = 489 Score = 65.7 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 70/387 (18%), Positives = 130/387 (33%), Gaps = 85/387 (21%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG---------------- 48 VVVLGGG +GL +++ L +A KV ++E+ R GG + + RG Sbjct: 14 VVVLGGGPAGLCSAFELQKAG--YKVTVLEARTRPGGRVWTARGGSEETDLSGETQKCTF 71 Query: 49 PNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEV---------LPVRGDHPAAQNRFL 99 G + +G I + TL ELG++ + + + D + Sbjct: 72 SEGHFYNVGATRIPQSHI----TLDYCRELGVEIQGFGNQNANTFVNYQSDTSLSGQSVT 127 Query: 100 YVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRE--LTKPRGKEPDETVHSFAQRRLGPE 157 Y R + + L + L + +E + + F G Sbjct: 128 Y------------RAAKADTFGYMSELLKKATDQGALDQVLSREDKDALSEFL-SDFGDL 174 Query: 158 VASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIR 217 G + G+SR + +E GL G + P +IR Sbjct: 175 SDD--------GRYLGSSRRG---------YDSEPGA-----GLNFGTEKKPFAMQEVIR 212 Query: 218 QALAERWSQ----------WSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGR 267 + +S ++ GG++ + A + + + +++ G V + +EG Sbjct: 213 SGIGRNFSFDFGYDQAMMMFTPVGGMDRIYYAFQDRIGT--DNIVFGAEVTSMKNVSEGV 270 Query: 268 WKVSLRDS---SLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGA 324 S+ AD+ I IP ++ L + AL A S + ++Y Sbjct: 271 TVEYTAGGSKKSITADYAICTIPPHLVGRLQNNLPGDVLTALKAAKPSSSGKLGIEYSRR 330 Query: 325 HLPVQG--FGHLVPSSEDPGVLGIVYD 349 + +G + +D + YD Sbjct: 331 WWETEDRIYGGASNTDKDISQIMFPYD 357 >4DGK-A nrPDB Length = 501 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 92/282 (32%), Gaps = 30/282 (10%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + V+G G GLA + L A P V+L+E ++ GG G F+ GP I Sbjct: 2 KPTTVIGAGFGGLALAIRLQAAGIP--VLLLEQRDKPGGRAYVYEDQ-GFTFDAGPTVIT 58 Query: 63 PAGALGARTLLLVSELGLDSEVLPVRGDHPA---AQNRFLYVGGALHALPT----GLRGL 115 A+ L +L E+LPV + + F Y R + Sbjct: 59 DPSAIEELFALAGKQLKEYVELLPVTPFYRLCWESGKVFNYDNDQTRLEAQIQQFNPRDV 118 Query: 116 --LRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAG 173 R +S+ +F G +L SF R + LA R V++ Sbjct: 119 EGYRQFLDYSRAVFKEGYLKL-------GTVPFLSF--RDMLRAAPQLAKLQAWRSVYSK 169 Query: 174 NSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGL 233 + + + + S+L+G A + + AL W W RGG Sbjct: 170 VASYIEDEHLRQAF-----SFHSLLVGGNPFATSSIYT----LIHALEREWGVWFPRGGT 220 Query: 234 EMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDS 275 L Q + G V+ V + V L D Sbjct: 221 GALVQGMIKLFQDLGGEVVLNARVSHMETTGNKIEAVHLEDG 262 >3WE0-A nrPDB Length = 580 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 107/290 (36%), Gaps = 35/290 (12%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRS--VRGPNGAIFELGPR 59 G V ++G GI+GL A+Y L + P V+ E+S ++GG +RS G +G I ELG Sbjct: 65 GEEVAIVGAGIAGLVAAYELMKLGLKP--VVYEAS-KMGGRLRSQAFNGTDGIIAELGGM 121 Query: 60 GIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTG--LRGLLR 117 P + V +LGL+++ P PA+++ + + G + L L + Sbjct: 122 RF-PVSSTAFYHY--VDKLGLETKPFP-NPLTPASRSTVIDLEGQTYYAEKAADLPALFQ 177 Query: 118 PSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRE 177 +G R + + + RL + L Sbjct: 178 EVTDAWADALESGARF------GDIQQAIRDRDVPRLKELW--NTLVPLWDDRTF--YDF 227 Query: 178 LSIRSCFPSL-FQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAE-RWSQWSLRGGLEM 235 ++ F L FQ + + G P + R + Q + GG+E Sbjct: 228 VATSKAFAKLSFQHREVFGQVGFGTGGWDSDFPNSMLEIFRVVMTNCDDHQHLVVGGVEQ 287 Query: 236 LPQALETHL---------TSRGVSVLRGQPVCG---LSLQAEGRWKVSLR 273 +PQ + H+ + S+ G P G ++ ++GR V+ Sbjct: 288 VPQGIWRHVPERCAHWPEGTSLSSLHGGAPRTGVKRIARASDGRLAVTDN 337 >4IV9-A nrPDB Length = 557 Score = 59.5 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 34/133 (25%), Positives = 51/133 (38%), Gaps = 12/133 (9%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSV---RGPNGAIFELGPRG 60 V ++G GISGL A+ L RA VVL ES +R+GG + S + I E+G Sbjct: 40 RVAIVGAGISGLVAATELLRAGVK-DVVLYESRDRIGGRVWSQVFDQTRPRYIAEMGAMR 98 Query: 61 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTG--LRGLLRP 118 P+ + + G+ + P + L+ G + P G L R Sbjct: 99 FPPS---ATGLFHYLKKFGIST---STTFPDPGVVDTELHYRGKRYHWPAGKKPPELFRR 152 Query: 119 SPPFSKPLFWAGL 131 + L G Sbjct: 153 VYEGWQSLLSEGY 165 >3ABT-A nrPDB Length = 662 Score = 59.2 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 62/158 (39%), Gaps = 9/158 (5%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRP 63 V+++G G+SGLAA+ L V L+E+ +R+GG + + R N + +LG + Sbjct: 109 KVIIIGSGVSGLAAARQLQSFGM--DVTLLEARDRVGGRVATFRKGN-YVADLGAMVV-- 163 Query: 64 AGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYV-GGALHALPTGLRGLLRPSPPF 122 G G ++ ++ ++ + ++ P + V + LL + Sbjct: 164 TGLGGNPMAVVSKQVNME--LAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYL 221 Query: 123 SKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVAS 160 S L + L + E V ++ + E Sbjct: 222 SHQLDFNVLNN-KPVSLGQALEVVIQLQEKHVKDEQIE 258 >3NK2-X nrPDB Length = 431 Score = 56.8 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 99/307 (32%), Gaps = 44/307 (14%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRS--VRGPNGAIFELGPRGIRP 63 +V+GGG SGL A+ L+ A KV+L+E ERLGG S R G E+G + Sbjct: 5 IVVGGGFSGLKAARDLTNAG--KKVLLLEGGERLGGRAYSRESRNVPGLRVEIGGAYL-- 60 Query: 64 AGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGAL---HALP-TGLRGLLRPS 119 L +EL D +P R A+ +P + + + Sbjct: 61 ---HRKHHPRLAAEL--DRYGIPTAAASEFTSFRHRLGPTAVDQAFPIPGSEAVAVEAAT 115 Query: 120 PPFSKPLFWAGLRELTKPRGKEP-DETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSREL 178 + L + + + E D ++ + + P V+ + + + + + Sbjct: 116 YTLLRDAHRIDLEKGLENQDLEDLDIPLNEYVDKLDLPPVSRQFLLAWAWNMLGQPADQA 175 Query: 179 SIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQ 238 S + Q H +LG++L G L Sbjct: 176 SAL----WMLQLVAAHHYSILGVVLSLDEV--------------------FSNGSADLVD 211 Query: 239 ALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAE 298 A+ + + V G+ + + +A VI A P + ++ Sbjct: 212 AMSQEIP----EIRLQTVVTGIDQSGDVVNVTVKDGHAFQAHSVIVATPMNTWRRIVFTP 267 Query: 299 AAPLARA 305 A P R Sbjct: 268 ALPERRR 274 >5L3D-A nrPDB Length = 852 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 62/158 (39%), Gaps = 9/158 (5%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRP 63 V+++G G+SGLAA+ L V L+E+ +R+GG + + R N + +LG + Sbjct: 280 KVIIIGSGVSGLAAARQLQSFGM--DVTLLEARDRVGGRVATFRKGN-YVADLGAMVV-- 334 Query: 64 AGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYV-GGALHALPTGLRGLLRPSPPF 122 G G ++ ++ ++ + ++ P + V + LL + Sbjct: 335 TGLGGNPMAVVSKQVNME--LAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYL 392 Query: 123 SKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVAS 160 S L + L + E V ++ + E Sbjct: 393 SHQLDFNVLNN-KPVSLGQALEVVIQLQEKHVKDEQIE 429 >5ZBC-A nrPDB Length = 451 Score = 55.7 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 93/296 (31%), Gaps = 59/296 (19%) Query: 5 VVVLGGGISGLAASYHLSRAPC--PPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + ++G GISGL + HL +P + + + + GG IRS A ELG Sbjct: 27 ICIVGAGISGLTCASHLLDSPACRGLSLRIFDMQQEAGGRIRSKMLDGKASIELGAGRYS 86 Query: 63 PAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPF 122 P HP Q+ + P Sbjct: 87 P-------------------------QLHPHFQSAMQHYSQKSEVYPFTQLKFKSHVQQK 121 Query: 123 SKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRS 182 K + EL+ + E+ F R G + A G R + + Sbjct: 122 LKR----AMNELSPRLKEHGKESFLQFVSRYQGHDSA------------VGMIRSMGYDA 165 Query: 183 CFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALET 242 F AE + ++G P+ + A +W ++ G L Q ++ Sbjct: 166 LFLPDISAEMAYD--IVG--------KHPEIQSVTDNDANQW--FAAETGFAGLIQGIKA 213 Query: 243 HLTSRGVSVLRGQPVCGLSLQAEG-RWKVSLRDS---SLEADHVISAIPASVLSEL 294 + + G G + + +G +++ D H+I AIP S ++ L Sbjct: 214 KVKAAGARFSLGYRLLSVRTDGDGYLLQLAGDDGWKLEHRTRHLILAIPPSAMAGL 269 >3BI4-A nrPDB Length = 516 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 35/57 (61%), Gaps = 1/57 (1%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPR 59 + V+++G GI+GL A+ L + +++E+ +R+GG +++V G G +++G Sbjct: 9 KKVIIIGAGIAGLKAASTLHQNGI-QDCLVLEARDRVGGRLQTVTGYQGRKYDIGAS 64 >4FWE-A nrPDB Length = 796 Score = 52.2 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 64/415 (15%), Positives = 118/415 (28%), Gaps = 80/415 (19%) Query: 24 APCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSE 83 KV ++E+ +R+GG + + G G + + G + L+ +LG+ Sbjct: 376 HNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIV--NGCINNPVALMCEQLGISMH 433 Query: 84 VLPVRGD---------HPAAQNRFLYVGGALHALPTGLRGLLR--PSPPFSKPLFWAGLR 132 R D P R + AL + + R P + + + Sbjct: 434 KFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKI-EEIYK 492 Query: 133 ELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQ 192 K G + E Q L A S V A + + F Sbjct: 493 AFIKESGIQFSELEGQVLQFHLSN--LEYACGSNLHQVSARSWDHNEFFAQFA------- 543 Query: 193 THRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVL 252 L G ++ + L L + Sbjct: 544 -------------------------------GDHTLLTPGYSVIIEKLAEGLD-----IQ 567 Query: 253 RGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSE----LLPAEAAPLARALSA 308 PV + + + + A V+ +P ++L + P + +A+++ Sbjct: 568 LKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINS 627 Query: 309 ITAVSVAVVNLQYQGAHL--PVQG---FGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGL 363 + A + + LQ+ VQG FGH+ PS+ G+ + YD + L Sbjct: 628 LGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYD----MDPQKKHSVL 683 Query: 364 RVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKE--MPSHCLVHLHK 416 + AS L + Q+ +E P+ V Sbjct: 684 MSVIA------GEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWS 732 >3X0V-A nrPDB Length = 541 Score = 52.2 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 25/109 (22%), Positives = 41/109 (37%), Gaps = 5/109 (4%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCP-PKVVLVESSERLGGWIRSVRGPNG--AIFELGPR 59 R V ++G G+SGL + L P + ESS R GG + + + +++G Sbjct: 8 RKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHHFTDAKHDYYDIGAM 67 Query: 60 GIRPAGALGARTLLLVSELGLDSEVLPVRG-DHPAAQNRFLYVGGALHA 107 P RT L G+ + G + P N + G + Sbjct: 68 RY-PDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLYNNHFFAKGVVDP 115 >6CR0-A nrPDB Length = 440 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 95/316 (30%), Gaps = 50/316 (15%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAG 65 +V+G G SGL A+ LS V+++E+ RLGG V G E+G G+ Sbjct: 12 IVVGAGFSGLVAARELSAQG--RSVLIIEARHRLGGRTHVV-NFLGRPVEIGGAGV---H 65 Query: 66 ALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKP 125 + G + P+ A ++ G +P + Sbjct: 66 WCQPHVFAEMQRYGFGFKEAPLADLDKA---YMVFADGQKIDVP---PATFDEEYTTAFE 119 Query: 126 LFWAGLRELT-KPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRG-------VFAGNSRE 177 F + REL +P + V + + SL ++ L ++ G Sbjct: 120 KFCSRSRELFPRPYSPLDNHEVSNLDGVSARDHLESLGLNELQLASMNAELTLYGGAP-- 177 Query: 178 LSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLP 237 + +PS + ++ + ++ ++GG L Sbjct: 178 -TTELSYPSFVKF-------------------HALASWDTITFTDSEKRYHVQGGTNALC 217 Query: 238 QALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSEL--- 294 QA+ G PV ++ G A + +P V +++ Sbjct: 218 QAI---FDDCRADSEFGVPVEAVAQTDNGVTVTLADKRVFRALTCVLTLPTKVYADVRFE 274 Query: 295 --LPAEAAPLARALSA 308 LP E Sbjct: 275 PPLPPEKRAFIEHAEM 290 >2VVL-G nrPDB Length = 495 Score = 48.8 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 63/338 (18%), Positives = 112/338 (33%), Gaps = 45/338 (13%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 V+V+GGG GL A+ L+ A K +L+E+ +R+GG S +G +E+G + Sbjct: 42 VIVIGGGYCGLTATRDLTVAG--FKTLLLEARDRIGGRSWS-SNIDGYPYEMGGTWVHWH 98 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSK 124 + R + H A F + G H LR +P S Sbjct: 99 QSHVWREITRYK-------------MHNALSPSFNFSRGVNHFQ-------LRTNPTTST 138 Query: 125 PLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCF 184 + EL + + V R + P + R E+S Sbjct: 139 YMTHEAEDELLRSALHKF-TNVDGTNGRTVLPFPHDMFYVPEFR-----KYDEMSYSERI 192 Query: 185 PSLF-QAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEML------- 236 + + RS L +L +S+ S ++ +G ++ L Sbjct: 193 DQIRDELSLNERSSLEAFILLCSGGTLENSSFGEFLHWWAMSGYTYQGCMDCLMSYKFKD 252 Query: 237 PQAL------ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASV 290 Q+ E + + + G PV + + + + A V+ IP +V Sbjct: 253 GQSAFARRFWEEAAGTGRLGYVFGCPVRSVVNERDAARVTARDGREFVAKRVVCTIPLNV 312 Query: 291 LS--ELLPAEAAPLARALSAITAVSVAVVNLQYQGAHL 326 LS + PA + A+ A V+ + + Sbjct: 313 LSTIQFSPALSTERISAMQAGHVSMCTKVHAEVDNKDM 350 >4REP-A nrPDB Length = 495 Score = 48.0 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 41/262 (15%), Positives = 83/262 (31%), Gaps = 15/262 (5%) Query: 27 PPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSEL---GLDSE 83 V + E ++ GG + ++ +G F+LGP + L E+ G S+ Sbjct: 24 GYSVTIFEKNDYAGGKLHAIE-KDGYRFDLGPSLFTLPHLVENLFALFPEEIIDFGYKSK 82 Query: 84 VLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPD 143 + + + G L T + + K + L K + + Sbjct: 83 AISFH---------YFWDDGTLFKASTDSSQFIEDASKVFKEEKSTIKKYLAK-SKSKYE 132 Query: 144 ETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLL 203 T F ++ L ++D++ V A + + S F+ + + Sbjct: 133 LTKSLFLEKSLHKATTYFSLDTVKAIVHAPFLGLNNTLNDENSKFKNPKLTQLFNRYATY 192 Query: 204 GAGRTPQPDSALIRQALAERW-SQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSL 262 Q + E + GG+ + Q+L GV + V ++ Sbjct: 193 NGSSPYQTPGIMTMIPHLELGLGTYYPDGGMHRISQSLFELAQKVGVKFRFRESVTNITT 252 Query: 263 QAEGRWKVSLRDSSLEADHVIS 284 V ++ S +D V+S Sbjct: 253 SKNKVTGVETKNGSYLSDLVVS 274 >5Z70-A nrPDB Length = 605 Score = 45.7 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 26/158 (16%), Positives = 53/158 (33%), Gaps = 18/158 (11%) Query: 2 GRTVVVLGGGISGLAASYHLSRAP--CPPKVVLVESSERLGGWIRSVRGPNGAIFELGPR 59 GR ++G GI+GLA++++L R + ++++ GG + G R Sbjct: 4 GRKAWIIGSGIAGLASAFYLIRDGRMKGQDITILDAVGTPGGSLDGSGNAEDGYLIRGGR 63 Query: 60 GIRPAGALGARTLLLVSELG-------LDSEVLPVRGDHPAAQNRFLYVGGALHALPTGL 112 + + L LD D +++R ++ G + Sbjct: 64 EMNWNYDHFWDLFQDIPALEYPSPYSVLDEYRAVNDNDPNWSKSRLMHKQGQIRDF---- 119 Query: 113 RGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFA 150 + S W ++ L K + D T+ + Sbjct: 120 -----STLGLSSAHQWELIKLLLKRKEDLDDITIEQYF 152 >4ZCC-A nrPDB Length = 336 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 44/105 (41%), Gaps = 12/105 (11%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 + ++G GI+GL+A+ L+ A +V L + S GG + S R G++ ++G + Sbjct: 5 IAIIGTGIAGLSAAQALTSAG--HQVHLFDKSRGSGGRMSSKRSDAGSL-DMGAQYFT-- 59 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALP 109 AR + + V P + + GG L P Sbjct: 60 ----ARDRRFATAVKQWQAQGHVSEWTPL---LYNFHGGRLSPSP 97 >3UKH-A nrPDB Length = 519 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 62/384 (16%), Positives = 125/384 (32%), Gaps = 38/384 (9%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPA 64 V+V+G G +GL A+ L++ P ++V+S+E GG + P G ++++G I Sbjct: 9 VLVIGAGPTGLGAAKRLNQID-GPSWMIVDSNETPGGLASTDVTPEGFLYDVGGHVIFSH 67 Query: 65 GALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALP-TGLRGLLRPSPPFS 123 LD + + + ++ G P +L Sbjct: 68 YKYFDDC--------LDEALPKEDDWYTHQRISYVRCQGQWVPYPFQNNISMLPKEEQVK 119 Query: 124 KPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSC 183 + +P T + R +G +A L M V+A + ++ Sbjct: 120 CIDGMIDAALEARVANTKPK-TFDEWIVRMMGTGIADLFMRPYNFKVWAVPTTKM----- 173 Query: 184 FPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERW-----SQWSLRGGLEMLPQ 238 + LG + A + +I A W ++ RGG + Sbjct: 174 -----------QCAWLGERVAAPNLKAVTTNVILGKTAGNWGPNATFRFPARGGTGGIWI 222 Query: 239 ALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAE 298 A+ L V ++ A + +++ ++S + L+E + + Sbjct: 223 AVANTLPKEKTRFGEKGKVTKVN--ANNKTVTLQDGTTIGYKKLVSTMAVDFLAEAMNDQ 280 Query: 299 AAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLV--PSSEDPGVLGIVYDSVAFPEQ 356 L + S V+ + +G+ G + P P ++ + + Q Sbjct: 281 E--LVGLTKQLFYSSTHVIGVGVRGSRPERIGDKCWLYFPEDNCPFYRATIFSNYSPYNQ 338 Query: 357 DGSPPGLRVTVMLGGSWLQTLEAS 380 + L + GS Q+ EA Sbjct: 339 PEASKKLPTMQLADGSRPQSTEAK 362 >3KKJ-A nrPDB Length = 336 Score = 41.8 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 3/66 (4%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 M + ++G GI+GL+A+ L+ A +V L + S GG + S R GA+ ++G + Sbjct: 1 MTVPIAIIGTGIAGLSAAQALTAAG--HQVHLFDKSRGSGGRMSSKRSDAGAL-DMGAQY 57 Query: 61 IRPAGA 66 Sbjct: 58 FTARDR 63 >3FPZ-A nrPDB Length = 326 Score = 41.4 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 15/37 (40%), Positives = 25/37 (67%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 V+++G G SGL+A+Y +++ KV ++ESS GG Sbjct: 68 VIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGG 104 >4UIR-A nrPDB Length = 646 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 51/160 (31%), Gaps = 18/160 (11%) Query: 4 TVVVLGGGISGLAASYHLSR--APCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGI 61 + ++G GI+G++A+Y+ R + +E GG + P G R + Sbjct: 64 KIYIIGSGIAGMSAAYYFIRDGHVPAKNITFLEQLHIDGGSLDGAGNPTDGYIIRGGREM 123 Query: 62 RPAGALGARTLLLVSELG-------LDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRG 114 + L LD L D ++ R + G + G Sbjct: 124 DMTYENLWDMFQDIPALEMPAPYSVLDEYRLINDNDSNYSKARLINNKGEIKDFSK--FG 181 Query: 115 LLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRL 154 L + A +R L K + + D T+ + Sbjct: 182 LNKMDQL-------AIIRLLLKNKEELDDLTIEDYFSESF 214 >5TWC-A nrPDB Length = 344 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 8/90 (8%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 + V ++GGG SGL AS++ V L++ LGG +R P I+++G + Sbjct: 2 KDVTIIGGGPSGLYASFYA--GLRDMSVRLIDVQSELGGKMRIY--PEKIIWDIGGIAPK 57 Query: 63 PAGALGARTLL----LVSELGLDSEVLPVR 88 P + T+ E+ L+ V+ +R Sbjct: 58 PCHEILKDTIKQGLYFKPEVHLNERVVDIR 87 >3JSK-A nrPDB Length = 344 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 22/37 (59%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 +V++G G GL+A+Y LS ++ +VE+ GG Sbjct: 82 IVIVGAGSCGLSAAYVLSTLRPDLRITIVEAGVAPGG 118 >3LXD-A nrPDB Length = 415 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 13/44 (29%), Positives = 22/44 (50%), Gaps = 2/44 (4%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRS 45 + VV+GGG GL A+ L++ V L+E+ R+ + Sbjct: 152 AKNAVVIGGGYIGLEAAAVLTKFGV--NVTLLEALPRVLARVAG 193 >3T14-A nrPDB Length = 437 Score = 38.4 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 41/122 (33%), Gaps = 14/122 (11%) Query: 4 TVVVLGGGISGLAASYHLSRA-PCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIR 62 VV+LG G G+ A+Y + A +V L+ +++ P+ +G + Sbjct: 6 HVVILGAGTGGMPAAYEMKEALGSGHEVTLISAND------YFQFVPSNPWVGVG---WK 56 Query: 63 PAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALH----ALPTGLRGLLRP 118 + V G+ AQN L G +H + TG + Sbjct: 57 ERDDIAFPIRHYVERKGIHFIAQSAEQIDAEAQNITLADGNTVHYDYLMIATGPKLAFEN 116 Query: 119 SP 120 P Sbjct: 117 VP 118 >5NMX-A nrPDB Length = 425 Score = 38.4 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 2/39 (5%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 R V VLG G SGL A+ +L +A +V++ E +GG Sbjct: 2 RRVAVLGAGPSGLTAARYLKQAG--FEVMVFERYHHVGG 38 >5GSN-A nrPDB Length = 453 Score = 37.6 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 31/140 (22%), Positives = 48/140 (34%), Gaps = 16/140 (11%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCP----PKVVLVESSERLGG-WIRSVR---GPNGA 52 M + V V+G G SGLA A P++V E GG W + R NG Sbjct: 1 MTKRVAVIGAGPSGLAQLRAFQSAADQGAEIPEIVCFEKQANWGGLWNYTWRTGLDENGE 60 Query: 53 IFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGL 112 R + G + L ++ + +P F Y+ G +H Sbjct: 61 PVHC--SMYRYLWSNGPKEGLEFADYSFEEHFGKQIASYPPRAVLFDYIEGRVH------ 112 Query: 113 RGLLRPSPPFSKPLFWAGLR 132 + +R F+ P+ W Sbjct: 113 KADVRKWIRFNSPVRWVSYD 132 >3QJ4-A nrPDB Length = 342 Score = 37.6 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 33/78 (42%), Gaps = 3/78 (3%) Query: 4 TVVVLGGGISG-LAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNG--AIFELGPRG 60 V+++G G++G L A+ + P + + + ++ GG + + P+ +LG + Sbjct: 3 QVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKADDSGGRMTTACSPHNPQCTADLGAQY 62 Query: 61 IRPAGALGARTLLLVSEL 78 I + EL Sbjct: 63 ITCTPHYAKKHQRFYDEL 80 >4C5O-A nrPDB Length = 357 Score = 37.6 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPN 50 VVV+GGG SGL+A Y L R+ ++ E+S G W + + Sbjct: 6 VVVIGGGQSGLSAGYFLRRSGLSYVILDAEASP-GGAWQHAWHSLH 50 >3K30-A nrPDB Length = 690 Score = 37.2 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 47/145 (32%), Gaps = 12/145 (8%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRP 63 V+V+G G SGL A+ L VVL E+ LGG + P Sbjct: 393 RVLVVGAGPSGLEAARALGVRG--YDVVLAEAGRDLGGRVTQESAL--------PGLSAW 442 Query: 64 AGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHAL--PTGLRGLLRPSPP 121 R +L ++ + F +V A A G+ + P Sbjct: 443 GRVKEYREAVLAELPNVEIYRESPMTGDDIVEFGFEHVITATGATWRTDGVARFHTTALP 502 Query: 122 FSKPLFWAGLRELTKPRGKEPDETV 146 ++ + G +L R + + V Sbjct: 503 IAEGMQVLGPDDLFAGRLPDGKKVV 527 >1PS9-A nrPDB Length = 671 Score = 37.2 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 44/132 (33%), Gaps = 8/132 (6%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGW---IRSVRGPNGAIFELGPR 59 + + V+G G +GLA + ++ A +V L ++ +GG + + G L R Sbjct: 374 KNLAVVGAGPAGLAFA--INAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYETL--R 429 Query: 60 GIRPAGALGARTLLLVSELGLDSE-VLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRP 118 R + TL L + D R + G H +LR Sbjct: 430 YYRRMIEVTGVTLKLNHTVTADQLQAFDETILASGIVPRTPPIDGIDHPKVLSYLDVLRD 489 Query: 119 SPPFSKPLFWAG 130 P + G Sbjct: 490 KAPVGNKVAIIG 501 >2GAG-B nrPDB Length = 405 Score = 36.8 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 28/64 (43%), Gaps = 2/64 (3%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIR--SVRGPNGAIFELGPRGIRP 63 +++GGG GLA +Y L++ V ++E GG + + + +++ Sbjct: 25 IIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDESAGIYEK 84 Query: 64 AGAL 67 + L Sbjct: 85 SLKL 88 >5L46-A nrPDB Length = 841 Score = 36.4 bits (82), Expect = 0.028, Method: Composition-based stats. Identities = 16/38 (42%), Positives = 24/38 (63%), Gaps = 1/38 (2%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWI 43 V++GGG G++ +YHL++A VVL+E SE G Sbjct: 26 VIIGGGCVGVSLAYHLAKAGMK-DVVLLEKSELTAGST 62 Score = 29.5 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 22/52 (42%) Query: 235 MLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAI 286 L AL G + PV L +++G W V S+ A+ +++A Sbjct: 170 SLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMRANRIVNAA 221 >3UP5-A nrPDB Length = 545 Score = 36.4 bits (82), Expect = 0.030, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 29/69 (42%), Gaps = 11/69 (15%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAG 65 VV+G G++G+ ++ +++A KV+ +E+ E +GG + P Sbjct: 13 VVIGAGVTGIYQAFLINQAGM--KVLGIEAGEDVGGT---------WYWNRYPGCRLDTE 61 Query: 66 ALGARTLLL 74 + L Sbjct: 62 SYAYGYFAL 70 >4P9S-A nrPDB Length = 848 Score = 36.0 bits (81), Expect = 0.035, Method: Composition-based stats. Identities = 16/38 (42%), Positives = 24/38 (63%), Gaps = 1/38 (2%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWI 43 V++GGG G++ +YHL++A VVL+E SE G Sbjct: 27 VIIGGGCVGVSLAYHLAKAGM-RDVVLLEKSELTAGST 63 >1RP0-A nrPDB Length = 284 Score = 35.3 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 15/37 (40%), Positives = 24/37 (64%), Gaps = 1/37 (2%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 VVV+G G +GL+A+Y +S+ +V ++E S GG Sbjct: 42 VVVVGAGSAGLSAAYEISK-NPNVQVAIIEQSVSPGG 77 >1FL2-A nrPDB Length = 310 Score = 35.3 bits (79), Expect = 0.057, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 8/55 (14%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVE------SSERLGGWIRSVRGPN 50 G+ V V+GGG SG+ A+ + A V L+E + + L +RS++ + Sbjct: 144 GKRVAVIGGGNSGVEAA--IDLAGIVEHVTLLEFAPEMKADQVLQDKLRSLKNVD 196 >4YKF-A nrPDB Length = 521 Score = 35.3 bits (79), Expect = 0.059, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 28/55 (50%), Gaps = 8/55 (14%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVE------SSERLGGWIRSVRGPN 50 G+ V V+GGG SG+ A+ + A V L+E + + L +RS++ + Sbjct: 355 GKRVAVIGGGNSGVEAA--IDLAGIVEHVTLLEFAPEMKADQVLQDKLRSLKNVD 407 >4IA5-A nrPDB Length = 591 Score = 35.3 bits (79), Expect = 0.061, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 38/113 (33%), Gaps = 8/113 (7%) Query: 3 RTVVVLGGGISGLAASYHLSR--APCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRG 60 ++ ++G G++GL+ + L R + ++E GG + PN G R Sbjct: 23 KSAYIIGSGLAGLSTAVFLVRDAQMKGENIHILEELPVAGGSLDGADRPNAGFVVRGGRE 82 Query: 61 IRPAGALGARTLLLVSELG------LDSEVLPVRGDHPAAQNRFLYVGGALHA 107 + + L LD + D ++ R +Y G Sbjct: 83 MENHFECLWDMYRSIPSLEVPGASYLDEYYWLDKEDPNSSNCRLIYNRGDRLP 135 >4EMJ-A nrPDB Length = 410 Score = 34.9 bits (78), Expect = 0.075, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 31/74 (41%), Gaps = 11/74 (14%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSE---------RLGGWIRSVRGPNGAIF 54 ++++GGG+ G + + V ++E+ + R+G W+R + G Sbjct: 145 RLLIVGGGLIGCEVATTARK--LGLSVTILEAGDELLVRVLGRRIGAWLRGLLTELGVQV 202 Query: 55 ELGPRGIRPAGALG 68 ELG + +G Sbjct: 203 ELGTGVVGFSGEGQ 216 >5TUF-A nrPDB Length = 409 Score = 34.9 bits (78), Expect = 0.090, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 27/50 (54%), Gaps = 2/50 (4%) Query: 1 MGRTV--VVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 M + + +V+G G++G A +Y L R P ++ ++ R GG +RG Sbjct: 22 MTKHIKILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRG 71 >4OVI-A nrPDB Length = 542 Score = 34.5 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 23/55 (41%), Gaps = 11/55 (20%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPR 59 V+V+G G SGL A Y L V ++E++ +GG + P Sbjct: 19 VLVVGAGFSGLYALYRLRE--LGRSVHVIETAGDVGG---------VWYWNRYPG 62 >4Z44-A nrPDB Length = 554 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 29/56 (51%), Gaps = 3/56 (5%) Query: 3 RTVVVLGGGISG-LAASYHLSRAPCPPKVVLVESS--ERLGGWIRSVRGPNGAIFE 55 + +V++GGG +G +AASY + + L+ES+ R+G ++ F+ Sbjct: 22 KNIVIVGGGTAGWMAASYLVRALQQQANITLIESAAIPRIGVGEATIPSLQKVFFD 77 >2GV8-A nrPDB Length = 447 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 17/39 (43%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 R + ++G G SGL + L +V L E GG Sbjct: 7 RKIAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGG 45 >6GAR-A nrPDB Length = 349 Score = 34.1 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 16/54 (29%), Positives = 27/54 (50%), Gaps = 4/54 (7%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGP 58 V V+GGG +GL ++++ K+ +E LGG I P I+++G Sbjct: 9 VTVIGGGPAGLYSAFYSGLREMRTKI--IEFHPHLGGKIHVY--PEKMIWDVGG 58 >5TUM-A nrPDB Length = 410 Score = 33.7 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 24/45 (53%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 ++V+G G++G A Y L R P ++ +S R GG VRG Sbjct: 27 KILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVRG 71 >3ATQ-A nrPDB Length = 453 Score = 33.7 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 16/40 (40%), Positives = 26/40 (65%), Gaps = 4/40 (10%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSE--RLGGW 42 V+++GGG +G +A+Y LSR K++LV+S R+G Sbjct: 9 VLIIGGGFAGSSAAYQLSRRGL--KILLVDSKPWNRIGDK 46 >5JFC-L nrPDB Length = 474 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 G+ V ++G G +GL + L A +V + E+ + GG Sbjct: 154 GKKVAIIGAGPAGLTCAADL--AKMGYEVTIYEALHQPGG 191 >5VJ7-A nrPDB Length = 476 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 G+ V ++G G +GL + L A +V + E+ + GG Sbjct: 154 GKKVAIIGAGPAGLTCAADL--AKMGYEVTIYEALHQPGG 191 >3R9U-A nrPDB Length = 315 Score = 33.0 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 2/41 (4%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRS 45 V ++GGG +GL+A + +R VV+ E GG I S Sbjct: 7 VAIIGGGPAGLSAGLYATRGGLK-NVVMFE-KGMPGGQITS 45 >6HNS-A nrPDB Length = 454 Score = 33.0 bits (73), Expect = 0.30, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 48/130 (36%), Gaps = 12/130 (9%) Query: 1 MGRTVVVLGGGISGLAA--SYH--LSRAPCPPKVVLVESSERLGG-WIRSVR---GPNGA 52 M V ++G G GLA ++ ++ P++V E GG W + R +G Sbjct: 1 MNTRVAIIGAGPCGLAQLRAFQSAAAKGAAIPELVCFEKQSDWGGMWNYTWRTGVDEHGE 60 Query: 53 IFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGL 112 R + G + L ++ D G +P + + Y+ G + G+ Sbjct: 61 PVH--GSMYRYLWSNGPKECLEFADYTFDEHFGRPIGSYPPREVLWDYIKGRVE--KAGV 116 Query: 113 RGLLRPSPPF 122 R +R + Sbjct: 117 RDYIRFNTAV 126 >4YNU-A nrPDB Length = 571 Score = 33.0 bits (73), Expect = 0.34, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 19/34 (55%), Gaps = 1/34 (2%) Query: 6 VVLGGGISGLAASYHLSRAPCPPKVVLVESSERL 39 +V+GGG SGL + LS V+L+E+ + Sbjct: 9 IVVGGGTSGLVVANRLSE-NPDVSVLLLEAGASV 41 >5TUL-A nrPDB Length = 406 Score = 32.2 bits (71), Expect = 0.49, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 26/54 (48%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFEL 56 + ++V+G I+G A Y L+ P +V S R GG+ +RG + + Sbjct: 26 KKILVIGASIAGPALCYWLNHYGFQPTLVEKNQSTRKGGYAIDLRGIAVDVAKQ 79 >2VOU-A nrPDB Length = 397 Score = 32.2 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 14/27 (51%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKV 30 + V+GG ISGL A+ L A V Sbjct: 7 RIAVVGGSISGLTAALMLRDAGVDVDV 33 >5EZ7-A nrPDB Length = 392 Score = 32.2 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 9/105 (8%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGP----NGAIFELGPRG 60 ++++GGGI+GL + L RA VLVES+ GG +SV+ GA + L Sbjct: 10 ILIVGGGIAGLWLNARLRRAG--YATVLVESASLGGG--QSVKSQGIIHGGAKYALHGAL 65 Query: 61 IRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGAL 105 + A+ + LG D E L +RG ++ +L+ G L Sbjct: 66 TGASEAIADMPRRWRACLGSDGE-LDLRGVRLLSEAHYLWSPGGL 109 >4Y4N-A nrPDB Length = 286 Score = 32.2 bits (71), Expect = 0.58, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 21/30 (70%), Gaps = 2/30 (6%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVE 34 V ++GGG SGL A+ ++++ KVV++E Sbjct: 55 VAIVGGGPSGLTAARYIAKEG--YKVVVLE 82 >5TUK-A nrPDB Length = 408 Score = 31.8 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 24/45 (53%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRG 48 ++V+G GI+G A Y L R P +V ++ R GG +RG Sbjct: 27 KILVIGAGIAGPAVCYWLRRFGFSPILVERCANLRKGGHAVDIRG 71 >6GAS-A nrPDB Length = 331 Score = 31.8 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 29/54 (53%), Gaps = 3/54 (5%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGP 58 + ++GGG +GL +++ V ++ES +LGG + ++ P I+++ Sbjct: 12 ITIIGGGPTGLFTAFY--GGMRQASVKIIESLPQLGGQLSALY-PEKYIYDVAG 62 >2LDB-A nrPDB Length = 317 Score = 31.8 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 20/36 (55%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSE 37 G VVV+G G G + + L ++VL++++E Sbjct: 6 GARVVVIGAGFVGASYVFALMNQGIADEIVLIDANE 41 >2CVJ-A nrPDB Length = 180 Score = 31.8 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 14/32 (43%), Positives = 23/32 (71%), Gaps = 2/32 (6%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESS 36 V+V+GGG SGL+A+ L+RA KV++++ Sbjct: 4 VIVVGGGPSGLSAALFLARAGL--KVLVLDGG 33 >1V59-A nrPDB Length = 478 Score = 31.8 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 2/37 (5%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 41 VV++GGG +G A+ + A VE +LGG Sbjct: 8 VVIIGGGPAGYVAA--IKAAQLGFNTACVEKRGKLGG 42 >3FG2-P nrPDB Length = 404 Score = 31.8 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 20/43 (46%), Gaps = 2/43 (4%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRS 45 + VVV+G G GL + +V +VE + R+ + + Sbjct: 143 KHVVVIGAGFIGLEFAATARAKGL--EVDVVELAPRVMARVVT 183 >5ZBB-A nrPDB Length = 544 Score = 31.8 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 22/78 (28%), Gaps = 4/78 (5%) Query: 283 ISAIPASVLSELL-PAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDP 341 +S+ P S L A P + V A P G GH V S ED Sbjct: 368 VSSPPHPSTSGLQTSPIALPGVSSSDTHATVQQAT---GPSAFFWPDTGRGHAVLSEEDY 424 Query: 342 GVLGIVYDSVAFPEQDGS 359 F + + Sbjct: 425 KAAINFLIDQDFNTKHKA 442 >4AP1-A nrPDB Length = 549 Score = 31.8 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 21/55 (38%), Gaps = 11/55 (20%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPR 59 VVV+G GI+GL A + V E++ +GG + P Sbjct: 24 VVVVGAGIAGLYAIHRFRSQGL--TVRAFEAASGVGG---------VWYWNRYPG 67 >3IP1-A nrPDB Length = 404 Score = 31.4 bits (69), Expect = 0.83, Method: Composition-based stats. Identities = 19/36 (52%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSE 37 G VV+LGGG GLAA L A KV+L E SE Sbjct: 214 GDNVVILGGGPIGLAAVAILKHAGAS-KVILSEPSE 248 >6DLL-A nrPDB Length = 398 Score = 31.4 bits (69), Expect = 0.99, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 24/51 (47%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNG 51 M V ++G G SGL L +A +V +++E + G IR+ G Sbjct: 4 MKTQVAIIGAGPSGLLLGQLLHKAGIDNIIVERQTAEYVLGRIRAGVLEQG 54 >4Y4M-A nrPDB Length = 290 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 20/30 (66%), Gaps = 2/30 (6%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVE 34 VV++G G SGL + +L++ KVV++E Sbjct: 62 VVIVGAGPSGLTCARYLAKEG--FKVVVLE 89 >3RP7-A nrPDB Length = 407 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 15/28 (53%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKV 30 +V+G GI GL+A+ L ++ V Sbjct: 24 MKAIVIGAGIGGLSAAVALKQSGIDCDV 51 >5EVY-X nrPDB Length = 438 Score = 30.3 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 1/37 (2%) Query: 4 TVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLG 40 V V+GGGI+G A + LS++ V L E++ G Sbjct: 24 RVAVIGGGIAGTALALGLSKSS-HVNVKLFETAPAFG 59 >5XHU-A nrPDB Length = 329 Score = 30.3 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 2/45 (4%) Query: 2 GRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSV 46 G+ VV+ GGG + + + L P V +V E GG SV Sbjct: 150 GKRVVISGGGDTAVDWANELE--PIAASVTVVHRREEFGGMESSV 192 >2RGJ-A nrPDB Length = 402 Score = 30.3 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 21/35 (60%), Gaps = 1/35 (2%) Query: 5 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERL 39 +++ G GI GL+ + L +A KV L+ESS + Sbjct: 7 ILIAGAGIGGLSCALALHQAGIG-KVTLLESSSEI 40 >1C0L-A nrPDB Length = 363 Score = 29.9 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 18/29 (62%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVV 31 + VVVLG G+ GL+++ L+R ++ Sbjct: 7 KRVVVLGSGVIGLSSALILARKGYSVHIL 35 >1DOD-A nrPDB Length = 394 Score = 29.9 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 24/53 (45%) Query: 1 MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAI 53 M V ++G G SGL L +A ++ ++ + + G IR+ G + Sbjct: 1 MKTQVAIIGAGPSGLLLGQLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGMV 53 >2QAE-A nrPDB Length = 468 Score = 29.9 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 21/36 (58%), Gaps = 2/36 (5%) Query: 3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSER 38 +T+VV+GGG+ GL +R +V +VE + R Sbjct: 175 KTMVVIGGGVIGLELGSVWAR--LGAEVTVVEFAPR 208 >5JS6-A nrPDB Length = 274 Score = 29.5 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 21/69 (30%) Query: 342 GVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQL 401 G V D SP G+RV + G+ L L + + A L Sbjct: 158 ATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPL 217 Query: 402 GLKEMPSHC 410 G P+ Sbjct: 218 GRMGQPAEV 226 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.114 0.258 Lambda K H 0.267 0.0342 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,162,931 Number of Sequences: 36641 Number of extensions: 460010 Number of successful extensions: 1728 Number of sequences better than 10.0: 108 Number of HSP's better than 10.0 without gapping: 77 Number of HSP's successfully gapped in prelim test: 87 Number of HSP's that attempted gapping in prelim test: 1535 Number of HSP's gapped (non-prelim): 198 length of query: 477 length of database: 10,336,785 effective HSP length: 101 effective length of query: 376 effective length of database: 6,636,044 effective search space: 2495152544 effective search space used: 2495152544 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (28.0 bits)