BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P50102 (471 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4FIP-A nrPDB 976 0.0 2GFO-A nrPDB 138 5e-33 6DGF-A nrPDB 136 2e-32 5L8W-A nrPDB 134 6e-32 5K1A-A nrPDB 134 8e-32 2Y6E-A nrPDB 133 1e-31 6CPM-C nrPDB 132 3e-31 5L8H-A nrPDB 128 6e-30 3MTN-A nrPDB 123 2e-28 5WCH-A nrPDB 101 6e-22 5J7T-A nrPDB 97 2e-20 5JTV-A nrPDB 96 3e-20 5JTJ-A nrPDB 96 3e-20 5OHN-A nrPDB 96 3e-20 2F1Z-A nrPDB 95 6e-20 5OHK-A nrPDB 92 4e-19 5GVI-A nrPDB 87 1e-17 5CHV-A nrPDB 83 3e-16 6HEH-A nrPDB 77 2e-14 5GJQ-x nrPDB 64 2e-10 5TXK-A nrPDB 63 3e-10 2AYN-A nrPDB 62 6e-10 3IHP-A nrPDB 60 1e-09 3JCR-V nrPDB 52 4e-07 1VJV-A nrPDB 52 5e-07 5MPC-8 nrPDB 52 6e-07 6H4H-A nrPDB 50 2e-06 6H4J-A nrPDB 41 0.001 5O71-A nrPDB 40 0.002 3C5K-A nrPDB 35 0.10 5G0F-A nrPDB 34 0.18 1NI3-A nrPDB 33 0.19 2PVP-A nrPDB 32 0.41 5WLC-LP nrPDB 29 4.7 3AXH-A nrPDB 28 8.3 >4FIP-A nrPDB Length = 476 Score = 976 bits (2522), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/471 (99%), Positives = 471/471 (100%) Query: 1 MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC 60 MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC Sbjct: 6 MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC 65 Query: 61 LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD 120 LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD Sbjct: 66 LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD 125 Query: 121 VCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD 180 VCTKTMVPSMERRDGLSGLINMG+TCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD Sbjct: 126 VCTKTMVPSMERRDGLSGLINMGNTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD 185 Query: 181 KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE 240 KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE Sbjct: 186 KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE 245 Query: 241 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI 300 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI Sbjct: 246 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI 305 Query: 301 DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL 360 DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL Sbjct: 306 DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL 365 Query: 361 QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK 420 QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK Sbjct: 366 QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK 425 Query: 421 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN 471 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN Sbjct: 426 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN 476 >2GFO-A nrPDB Length = 396 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 112/358 (31%), Positives = 178/358 (49%), Gaps = 51/358 (14%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 L+GL N+G+TC+M+SILQCL + P+ ++ + NC ++ V E Sbjct: 61 ALTGLRNLGNTCYMNSILQCLCNAPH-----LADYFNRNCYQDDINRSNLLGHKGEVAEE 115 Query: 195 YG----ALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIH 250 +G AL T Q S + T KIN AGYSQQD+ E F+++ +H Sbjct: 116 FGIIMKALWTGQYRYISPKDFKIT--------IGKINDQFAGYSQQDSQELLLFLMDGLH 167 Query: 251 QS----------------YVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQN 294 + ++ D A+ + + + E I+ +F+G +S++ C C Sbjct: 168 EDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHK 227 Query: 295 NSKTTIDPFLDLSLDIKDKKK--LYECLDSFHKKEQLKDFN-YHCGECNSTQDAIKQLGI 351 S+T + F+ LSL + K L +CL F K+E+L D N ++C C + +D++K++ I Sbjct: 228 KSRT-FEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEI 286 Query: 352 HKLPSVLVLQLKRFEHLLNGS-NRKLDDFIEFPTY-LNMKNYCSTKEKDKHSENGKVPDI 409 KLP VL++ LKRF + +G +KL ++FP L++ Y + + Sbjct: 287 WKLPPVLLVHLKRFSY--DGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKK-------- 336 Query: 410 IYELIGIVSHKGTVNEGHYIAFCKISGGQ-WFKFNDSMVSSISQEEVLKEQAYLLFYT 466 Y L + +H G ++ GHY A+CK + Q WFKF+D VS IS V AY+LFYT Sbjct: 337 -YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYT 393 >6DGF-A nrPDB Length = 370 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 110/357 (30%), Positives = 168/357 (47%), Gaps = 47/357 (13%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 GL+GL N+G+TCFM+SILQCL + + + +++ + S A +V E Sbjct: 30 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDL------HHGSNAHTALVEEF 83 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQS-- 252 + T SS N T + GY+QQDA EF +F+++ +H Sbjct: 84 AKLIQTIWTSSP----NDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVN 139 Query: 253 --------------YVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKT 298 ++ D +++ R ++ + + +F G L+SS+ C C S T Sbjct: 140 RVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCS-T 198 Query: 299 TIDPFLDLSLDIKDKK----KLYECLDSFHKKEQLK-DFNYHCGECNSTQDAIKQLGIHK 353 DPF DLSL I + L +C+ F K++ L D C C + IK+ I + Sbjct: 199 VFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQR 258 Query: 354 LPSVLVLQLKRF-EHLLNGSNRKLDDFIEFPTY-LNMKNYCSTKEKDKHSENGKVPDIIY 411 P +LVL LKRF E + S KL F+ FP L+++ + S E H+ +Y Sbjct: 259 FPKILVLHLKRFSESRIRTS--KLTTFVNFPLRDLDLREFAS--ENTNHA--------VY 306 Query: 412 ELIGIVSHKGTVNEGHYIAFCKISG-GQWFKFNDSMVSSISQEEVLKEQAYLLFYTI 467 L + +H GT GHY A+C+ G G+W FNDS V+ +S +V AYLLFY + Sbjct: 307 NLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYEL 363 >5L8W-A nrPDB Length = 376 Score = 134 bits (338), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 105/357 (29%), Positives = 166/357 (46%), Gaps = 53/357 (14%) Query: 138 GLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 197 GL+N G+TC+ +S+LQ L YF R ++ + + R + +C D L+ + Sbjct: 46 GLVNFGNTCYCNSVLQAL----YFCRPFREKVLAYKSQPRKKESLLTCLAD-----LFHS 96 Query: 198 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDL 257 + T++ + +T K N+ Y QQDAHEF +++N I + Sbjct: 97 IATQKKKVGVIPPKK------FITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEER 150 Query: 258 PNAKEVSR----------ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLS 307 K+ R N+ VH +F+G+L + C C+ S D FLDLS Sbjct: 151 KQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDED-FLDLS 209 Query: 308 LDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFE 366 +D++ + CL F E L ++ Y+C EC S Q+A K++ + KLP +L L LKRF+ Sbjct: 210 VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFK 269 Query: 367 HLLNGSNR--KLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT-V 423 + ++ +R KL + FP L + N S + PD +Y+L+ +V H G+ Sbjct: 270 Y-MDQLHRYTKLSYRVVFPLELRLFN---------TSGDATNPDRMYDLVAVVVHCGSGP 319 Query: 424 NEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLK------------EQAYLLFYTIR 468 N GHYIA K S W F+D +V I + + + E Y+LFY R Sbjct: 320 NRGHYIAIVK-SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 375 >5K1A-A nrPDB Length = 331 Score = 134 bits (337), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 105/357 (29%), Positives = 166/357 (46%), Gaps = 53/357 (14%) Query: 138 GLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 197 GL+N G+TC+ +S+LQ L YF R ++ + + R + +C D L+ + Sbjct: 1 GLVNFGNTCYCNSVLQAL----YFCRPFREKVLAYKSQPRKKESLLTCLAD-----LFHS 51 Query: 198 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDL 257 + T++ + +T K N+ Y QQDAHEF +++N I + Sbjct: 52 IATQKKKVGVIPPKK------FITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEER 105 Query: 258 PNAKEVSR----------ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLS 307 K+ R N+ VH +F+G+L + C C+ S D FLDLS Sbjct: 106 KQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDED-FLDLS 164 Query: 308 LDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFE 366 +D++ + CL F E L ++ Y+C EC S Q+A K++ + KLP +L L LKRF+ Sbjct: 165 VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFK 224 Query: 367 HLLNGSNR--KLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT-V 423 + ++ +R KL + FP L + N S + PD +Y+L+ +V H G+ Sbjct: 225 Y-MDQLHRYTKLSYRVVFPLELRLFN---------TSGDATNPDRMYDLVAVVVHCGSGP 274 Query: 424 NEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLK------------EQAYLLFYTIR 468 N GHYIA K S W F+D +V I + + + E Y+LFY R Sbjct: 275 NRGHYIAIVK-SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 330 >2Y6E-A nrPDB Length = 367 Score = 133 bits (335), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 108/387 (27%), Positives = 173/387 (44%), Gaps = 76/387 (19%) Query: 129 SMERRDGLSGLINMGSTCFMSSILQCLIHNP----YFIRHSM-SQIHSNNCKVRSPDKCF 183 M + GL GL N+G+TCFM+S LQCL + YF++ ++I+ +N Sbjct: 1 GMHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDN---------- 50 Query: 184 SCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQ 243 + + E Y L + S + T + +GY QQD+ E Sbjct: 51 PLGMKGEIAEAYAELIKQMWSGRDAHVAPRM----FKTQVGRFAPQFSGYQQQDSQELLA 106 Query: 244 FIINQIHQSY-------VLDLPNA---------KEVSRANNKQCECIVHTVFEGSLESSI 287 F+++ +H+ L+L +A KE + + + ++ F G +S++ Sbjct: 107 FLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTL 166 Query: 288 VCPGCQNNSKTTIDPFLDLSLDIKDKK-------------------KLYECLDSFHKKEQ 328 VCP C S T DPF L+L + KK L +C++ F E Sbjct: 167 VCPECAKVS-VTFDPFCYLTLPLPLKKDRVMEGPMLQPQKKKKTTVALRDCIELFTTMET 225 Query: 329 LKDFN-YHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNR----KLDDFIEFP 383 L + + ++C C Q A K+ + LP +LV+ LKRF + NR KLD +EFP Sbjct: 226 LGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSY-----NRYWRDKLDTVVEFP 280 Query: 384 TY-LNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKIS-GGQWFK 441 LNM + N +Y+LI + +H G + GHY A+ K G+W+ Sbjct: 281 IRGLNMSEFVC---------NLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYY 331 Query: 442 FNDSMVSSISQEEVLKEQAYLLFYTIR 468 F+DS VS S+++++ + AY+LFY R Sbjct: 332 FDDSNVSLASEDQIVTKAAYVLFYQRR 358 >6CPM-C nrPDB Length = 349 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 107/354 (30%), Positives = 168/354 (47%), Gaps = 52/354 (14%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 GL GL N+G+TCFM+S +QCL + P + ++ + +P + + + Sbjct: 18 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNP-----LGMRGEIAKS 72 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQ--- 251 Y L KQ S S F T + +GY QQD E F+++ +H+ Sbjct: 73 YAEL-IKQMWSGKFSYVTPRAFK---TQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLN 128 Query: 252 -----SYV--------LDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKT 298 Y+ D A+E + K+ + I+ +F G +S++VCP C S Sbjct: 129 RIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKIS-V 187 Query: 299 TIDPFLDLSLDIKDKKK----LYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHK 353 T DPF L+L + KK L +C++ F KE+L + ++C C Q A K+L + Sbjct: 188 TFDPFCYLTLPLPMPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWS 247 Query: 354 LPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTY-LNMKNYCSTKEKDKHSENGKVPDIIYE 412 LP VLV+ LKRF + + KLD ++FP L+M C Y Sbjct: 248 LPPVLVVHLKRFSYSRYMRD-KLDTLVDFPINDLDMSG-CR-----------------YN 288 Query: 413 LIGIVSHKGTVNEGHYIAFCK-ISGGQWFKFNDSMVSSISQEEVLKEQAYLLFY 465 LI + +H G + GHY AF K G+W+ F+DS VS+ S+++++ + AY+LFY Sbjct: 289 LIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFY 342 >5L8H-A nrPDB Length = 359 Score = 128 bits (321), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 107/358 (29%), Positives = 164/358 (45%), Gaps = 53/358 (14%) Query: 138 GLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 197 GL+N G+TC+++S+LQ L YF R + + + + + +C D L+ + Sbjct: 29 GLVNFGNTCYVNSVLQAL----YFCRPFRENVLAYKAQQKKKENLLTCLAD-----LFHS 79 Query: 198 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQI-------- 249 + T++ + FI L K N Y QQDAHEF +++N I Sbjct: 80 IATQKKKVGVIPPKK---FISRLR---KENDLFDNYMQQDAHEFLNYLLNTIADILQEEK 133 Query: 250 ---HQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDL 306 Q+ L N E + NNK VH +F+G+L + C C+ S D FLDL Sbjct: 134 KQEKQNGKLKNGNMNEPAE-NNKPELTWVHEIFQGTLTNETRCLNCETVSSKDED-FLDL 191 Query: 307 SLDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRF 365 S+D++ + CL F E L + Y+C C S Q+A K++ + KLP +L L LKRF Sbjct: 192 SVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRF 251 Query: 366 EHLLNGSN-RKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT-V 423 +++ KL + FP L + N S + D +Y+L+ +V H G+ Sbjct: 252 KYMEQLRRYTKLSYRVVFPLELRLFN---------TSSDAVNLDRMYDLVAVVVHCGSGP 302 Query: 424 NEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLK------------EQAYLLFYTIRQ 469 N GHYI K S G W F+D +V I + + + E Y+LFY R+ Sbjct: 303 NRGHYITIVK-SHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE 359 >3MTN-A nrPDB Length = 373 Score = 123 bits (309), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 104/379 (27%), Positives = 168/379 (44%), Gaps = 73/379 (19%) Query: 135 GLSGLINMGSTCFMSSILQCLIH----NPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKI 190 G GL N+G+TCF++++LQCL + +R Q + + + F+ Sbjct: 21 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFA------ 74 Query: 191 VHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIH 250 ++ GAL + + T + F K + +GYSQQDA EF + ++ ++H Sbjct: 75 --DVIGALWHPDSCEAVNPTRFRAVF-------QKYVPSFSGYSQQDAQEFLKLLMERLH 125 Query: 251 -------------------------QSYVLDLPNAKEVSRAN-------NKQCECIVHTV 278 +L+ P + RAN ++ IV + Sbjct: 126 LEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVD-L 184 Query: 279 FEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKK------KLYECLDSFHKKEQLKDF 332 F G L+S + C C S TT + F DLSL I K L +C + F K+E+L+ Sbjct: 185 FVGQLKSCLKCQACGYRS-TTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESE 243 Query: 333 NYH-CGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFP-TYLNMKN 390 N C C + K+L + + P +LVL L RF GS +K ++FP L++ + Sbjct: 244 NAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSAS-RGSIKKSSVGVDFPLQRLSLGD 302 Query: 391 YCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSI 450 + S K +Y+L + +H G+V+ GHY A C+ G W +NDS VS + Sbjct: 303 FASDKAGSP----------VYQLYALCNHSGSVHYGHYTALCRCQTG-WHVYNDSRVSPV 351 Query: 451 SQEEVLKEQAYLLFYTIRQ 469 S+ +V + Y+LFY + Q Sbjct: 352 SENQVASSEGYVLFYQLMQ 370 >5WCH-A nrPDB Length = 421 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 97/386 (25%), Positives = 165/386 (42%), Gaps = 78/386 (20%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQI----------------HSNNCKVRS 178 G GL N G+TC+M+S++Q L P IR+ + I N V Sbjct: 6 GFVGLKNAGATCYMNSVIQQLYMIPS-IRNGILAIEGTGSDVDDDMSGDEKQDNESNVDP 64 Query: 179 PDKCF------------SCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWK- 225 D F S D+ + + G L Q + +R Y+ WK Sbjct: 65 RDDVFGYPQQFEDKPALSKTEDRAAYNI-GVLRHLQVIFGHLAASRLQ--YYVPRGFWKQ 121 Query: 226 ---INQNLAGYSQQDAHEFWQFIINQIHQSY-VLDLPNAKEVSRANNKQCECIVHTVFEG 281 + + Q DA EF+ +++ + ++ L P ++ V G Sbjct: 122 FRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHP--------------AMLSKVLGG 167 Query: 282 SLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFN-YHCGECN 340 S +C GC + + + F L++DI++ + L + L+ + K + L+ N YHC +CN Sbjct: 168 SFADQKICQGCPHRYECE-ESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCN 226 Query: 341 STQDAIKQLGIHKLPSVLVLQLKRFEHLLNGS-NRKLDDFIEFPTYLNMKNYCSTK---- 395 D +K+L I KLP VL +QLKRF++ K +D+ EFP L+M+ Y Sbjct: 227 KKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKL 286 Query: 396 ------------EKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAF-CKISGG----- 437 ++ + SE+ Y L+G++ H G + GHY ++ + +GG Sbjct: 287 EGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERN 346 Query: 438 QWFKFNDSMVSS--ISQEEVLKEQAY 461 +W+KF+D V+ + +E +K Q + Sbjct: 347 RWYKFDDGDVTECKMDDDEEMKNQCF 372 >5J7T-A nrPDB Length = 671 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 88/327 (26%), Positives = 139/327 (42%), Gaps = 47/327 (14%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GL N G+TC+M+S+LQ L +F ++ + K AL ++ +EL Sbjct: 2 GYVGLKNQGATCYMNSLLQTL----FFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYEL 57 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYV 254 Q S T + T + W + L + Q D E + +++ + Sbjct: 58 -------QHSDKPVGTKKLTK-----SFGW---ETLDSFMQHDVQELCRVLLDNVE---- 98 Query: 255 LDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKK 314 ++ E + +F G + S I C S D + D+ L IK KK Sbjct: 99 ---------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRRED-YYDIQLSIKGKK 148 Query: 315 KLYECLDSFHKKEQLK-DFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH-LLNGS 372 ++E + EQL D Y GE + Q+A K + LP VL LQL RF + Sbjct: 149 NIFESFVDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQ 207 Query: 373 NRKLDDFIEFPTYLNMKNYCS-TKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAF 431 N K++D EFP L + + T KD + Y L ++ H G + GHY+ + Sbjct: 208 NIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGGHYVVY 258 Query: 432 CKISG-GQWFKFNDSMVSSISQEEVLK 457 G G+W KF+D +VS ++EE ++ Sbjct: 259 LNPKGDGKWCKFDDDVVSRCTKEEAIE 285 >5JTV-A nrPDB Length = 594 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 88/327 (26%), Positives = 139/327 (42%), Gaps = 47/327 (14%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GL N G+TC+M+S+LQ L +F ++ + K AL ++ +EL Sbjct: 21 GYVGLKNQGATCYMNSLLQTL----FFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYEL 76 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYV 254 Q S T + T + W + L + Q D E + +++ + Sbjct: 77 -------QHSDKPVGTKKLTK-----SFGW---ETLDSFMQHDVQELCRVLLDNVE---- 117 Query: 255 LDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKK 314 ++ E + +F G + S I C S D + D+ L IK KK Sbjct: 118 ---------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRRED-YYDIQLSIKGKK 167 Query: 315 KLYECLDSFHKKEQLK-DFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH-LLNGS 372 ++E + EQL D Y GE + Q+A K + LP VL LQL RF + Sbjct: 168 NIFESFVDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQ 226 Query: 373 NRKLDDFIEFPTYLNMKNYC-STKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAF 431 N K++D EFP L + + T KD + Y L ++ H G + GHY+ + Sbjct: 227 NIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGGHYVVY 277 Query: 432 CKISG-GQWFKFNDSMVSSISQEEVLK 457 G G+W KF+D +VS ++EE ++ Sbjct: 278 LNPKGDGKWCKFDDDVVSRCTKEEAIE 304 >5JTJ-A nrPDB Length = 387 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 90/330 (27%), Positives = 140/330 (42%), Gaps = 53/330 (16%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GL N G+TC+M+S+LQ L +F ++ + K AL ++ +EL Sbjct: 21 GYVGLKNQGATCYMNSLLQTL----FFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYEL 76 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYV 254 Q S T + T + W + L + Q D E + +++ + Sbjct: 77 -------QHSDKPVGTKKLTK-----SFGW---ETLDSFMQHDVQELCRVLLDNVE---- 117 Query: 255 LDLPNAKEVSRANNKQCECIVHTV---FEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIK 311 N + C+ T+ F G + S I C S D + D+ L IK Sbjct: 118 ------------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRRED-YYDIQLSIK 164 Query: 312 DKKKLYECLDSFHKKEQLK-DFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH-LL 369 KK ++E + EQL D Y GE + Q+A K + LP VL LQL RF + Sbjct: 165 GKKNIFESFVDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQ 223 Query: 370 NGSNRKLDDFIEFPTYLNMKNYC-STKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHY 428 N K++D EFP L + + T KD + Y L ++ H G + GHY Sbjct: 224 TDQNIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGGHY 274 Query: 429 IAFCKISG-GQWFKFNDSMVSSISQEEVLK 457 + + G G+W KF+D +VS ++EE ++ Sbjct: 275 VVYLNPKGDGKWCKFDDDVVSRCTKEEAIE 304 >5OHN-A nrPDB Length = 370 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 94/382 (24%), Positives = 152/382 (39%), Gaps = 72/382 (18%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIR--HSMSQIHSNNCKVRSPDKCFSCALDKIVHE 193 + GL+N+G+TCFM+S+LQ L P FIR + +S + K P + + + Sbjct: 6 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQK-EPPSHQYLSLTLLHLLK 64 Query: 194 LYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIIN------ 247 Q + + L W+I + + +QDAHE + I + Sbjct: 65 ALSC----QEVTDDEVLDASCLLDVLRMYRWQI----SSFEEQDAHELFHVITSSLEDER 116 Query: 248 --QIHQSYVLDLPNAKEVSRANNKQCECIVHT-------------VFEGSLESSIVCPGC 292 Q +++ D+ + ++ S KQ C F G L S++VC C Sbjct: 117 DRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHC 176 Query: 293 QNNSKTTIDPFLDLSLDIKDKK-----KLYECLDSFHKKEQLKDFNYHCGECNSTQDA-- 345 ++ S D F LSL I L CL F E ++D C C + Sbjct: 177 EHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVV--CDNCTKIEAKGT 234 Query: 346 -------------IKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYC 392 +KQL + KLP L + L+R +G+ K + ++F L+M Y Sbjct: 235 LNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLDMDEY- 293 Query: 393 STKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCK---------ISGGQWFKFN 443 K+ N ++ L+ +V H G ++ GH++ + + + QW + Sbjct: 294 ------KYHSNAST--YLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVS 345 Query: 444 DSMVSSISQEEVLKEQAYLLFY 465 D V S +EVL AYLLFY Sbjct: 346 DDTVRKASLQEVLSSSAYLLFY 367 >2F1Z-A nrPDB Length = 522 Score = 95.1 bits (235), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 90/330 (27%), Positives = 140/330 (42%), Gaps = 53/330 (16%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GL N G+TC+M+S+LQ L +F ++ + K AL ++ +EL Sbjct: 174 GYVGLKNQGATCYMNSLLQTL----FFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYEL 229 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYV 254 Q S T + T + W + L + Q D E + +++ + Sbjct: 230 -------QHSDKPVGTKKLTK-----SFGW---ETLDSFMQHDVQELCRVLLDNVE---- 270 Query: 255 LDLPNAKEVSRANNKQCECIVHTV---FEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIK 311 N + C+ T+ F G + S I C S D + D+ L IK Sbjct: 271 ------------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRRED-YYDIQLSIK 317 Query: 312 DKKKLYECLDSFHKKEQLK-DFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH-LL 369 KK ++E + EQL D Y GE + Q+A K + LP VL LQL RF + Sbjct: 318 GKKNIFESFVDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQ 376 Query: 370 NGSNRKLDDFIEFPTYLNMKNYCS-TKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHY 428 N K++D EFP L + + T KD + Y L ++ H G + GHY Sbjct: 377 TDQNIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGGHY 427 Query: 429 IAFCKISG-GQWFKFNDSMVSSISQEEVLK 457 + + G G+W KF+D +VS ++EE ++ Sbjct: 428 VVYLNPKGDGKWCKFDDDVVSRCTKEEAIE 457 >5OHK-A nrPDB Length = 336 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 91/361 (25%), Positives = 147/361 (40%), Gaps = 64/361 (17%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIR--HSMSQIHSNNCKVRSPDKCFSCALDKIVHE 193 + GL+N+G+TCFM+S+LQ L P FIR + +S + K P + + + Sbjct: 6 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQK-EPPSHQYLSLTLLHLLK 64 Query: 194 LYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSY 253 Q + + L W+I + + +QDAHE + I + Sbjct: 65 ALSC----QEVTDDEVLDASCLLDVLRMYRWQI----SSFEEQDAHELFHVITS------ 110 Query: 254 VLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDK 313 L + ++ S ++ K F G L S++VC C++ S D F LSL I Sbjct: 111 --SLEDERDGSGSHWKS-----QHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAA 163 Query: 314 K-----KLYECLDSFHKKEQLKDFNYHCGECNSTQDA---------------IKQLGIHK 353 L CL F E ++D C C + +KQL + K Sbjct: 164 TWGHPLTLDHCLHHFISSESVRDVV--CDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGK 221 Query: 354 LPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYEL 413 LP L + L+R +G+ K + ++F L+M Y K+ N ++ L Sbjct: 222 LPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLSMDEY-------KYHSNAST--YLFRL 272 Query: 414 IGIVSHKGTVNEGHYIAFCK---------ISGGQWFKFNDSMVSSISQEEVLKEQAYLLF 464 + +V H G ++ GH++ + + + QW +D V S +EVL AYLLF Sbjct: 273 MAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLF 332 Query: 465 Y 465 Y Sbjct: 333 Y 333 >5GVI-A nrPDB Length = 444 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 101/440 (22%), Positives = 159/440 (36%), Gaps = 115/440 (26%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELY 195 + GL+N+G+T FM+S+LQ L P FIR + S N R + L + + +L Sbjct: 6 VPGLLNLGNTAFMNSLLQGLAACPSFIRW-LEDFTSQNSADRERTE-RETQLSRSLMQLL 63 Query: 196 GALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQ---- 251 AL SS + LL +++ + +QDAHE + + + + + Sbjct: 64 KAL-----SSHVPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELFHVLTSSLEEEQER 118 Query: 252 ----SYVLDLPNAKEVSRANNKQCEC----IVHTV---------FEGSLESSIVCPGCQN 294 +++ D+ ++ + K C +H + F G L S + C C+ Sbjct: 119 QPRVAHLFDMQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRHPFHGRLTSYMACKRCEQ 178 Query: 295 NSKTTIDPFLDLSLDIKDKK-----KLYECLDSFHKKEQLKDFNYHCGECNSTQDA---- 345 S D F LSL I + L +CL F E +K+ C C Q Sbjct: 179 QSPVHYDSFDSLSLSIPSIQWGRPVTLDQCLQHFISSETIKEVE--CENCTKQQAGELVN 236 Query: 346 -----------IKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNY--- 391 +KQL + KLP L + L+R GS K + ++F YL++ Y Sbjct: 237 GEVLESQRTTFVKQLKLGKLPQCLCIHLQRLTWSKEGSPIKRQEHVQFTEYLSLDRYKHC 296 Query: 392 ----------------CSTKEKD---------------KHSENGKVPDI----------- 409 S KD K NG P + Sbjct: 297 SAAQSQQKTSRTNKAKASADPKDKAIANGVDSEHCNNNKPQSNGTFPSVFLHSPGLSSQL 356 Query: 410 -----------IYELIGIVSHKGTVNEGHYIAFCKISGG---------QWFKFNDSMVSS 449 ++ L ++ H G ++ GH+I + + QW +D V Sbjct: 357 NLTYDYSTSEYLFRLTAVLVHHGDMHSGHFITYRRCPAAPRGTSPFSSQWLWVSDDSVRK 416 Query: 450 ISQEEVLKEQAYLLFYTIRQ 469 S +EVL AYLLFY Q Sbjct: 417 ASLQEVLSSSAYLLFYERMQ 436 >5CHV-A nrPDB Length = 323 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 53/350 (15%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYF--IRHSMSQIHSNNCKVRSPDKCFSCALDKIVH 192 GL GL N+G TC ++S+LQ + N F I ++ S + RS L+K+ Sbjct: 5 GLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLEKMQ- 63 Query: 193 ELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQS 252 +++Q + T L+ C K N L + Q DA + + I N + + Sbjct: 64 ------DSRQKAVLPTE---------LVQCLQKYNVPL--FVQHDAAQLYLTIWN-LTKD 105 Query: 253 YVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKD 312 + D + + +F + S++C GC S L LSL + D Sbjct: 106 QITDTDLTERL------------QGLFTIWTQESLICVGCTAESSRR-SKLLTLSLPLFD 152 Query: 313 K-----KKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH 367 K K L + L F + ++L + C C + L + LP L + L RF Sbjct: 153 KDAKPLKTLEDALRCFVQPKELASSDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSA 212 Query: 368 LLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGH 427 N K+ + FP L+ T+E + + +I YEL +++H G + GH Sbjct: 213 R-NSRTEKICHSVNFPQSLDFSQVLPTEED--LGDTKEQSEIHYELFAVIAHVGMADFGH 269 Query: 428 YIAFCK-ISGGQWFKFNDSMVSSISQEEV----------LKEQAYLLFYT 466 Y A+ + G+WF FNDS V ++ ++V +E AYLL YT Sbjct: 270 YCAYIRNPVDGKWFCFNDSHVCWVTWKDVQCTYGNHRYRWRETAYLLVYT 319 >6HEH-A nrPDB Length = 382 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 86/337 (25%), Positives = 144/337 (42%), Gaps = 44/337 (13%) Query: 132 RRDGLS-GLINMGSTCFMSSILQCLIHNPYFIR----HSMSQIHSNNCKVRSPDK--CFS 184 R DG GL N+G+TC+ S+++Q L P F R +S+ Q NC+ + + F Sbjct: 9 RVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFM 68 Query: 185 CALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQF 244 L + + G+ N K S+ + LL A++ ++ QQD EF Sbjct: 69 QELQYLFALMMGS-NRKFVDPSAA--------LDLLKGAFRSSEE----QQQDVSEFTHK 115 Query: 245 IINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVF-EGSLESSIVCPGCQNNSKTTIDPF 303 +++ + ++ L + +++ N + T EG E P C N + F Sbjct: 116 LLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGK---PFCNNET------F 166 Query: 304 LDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLK 363 L + + L ECL+ + + + + + ++ KLP VL +L Sbjct: 167 GQYPLQVNGYRNLDECLEG-----AMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFELS 221 Query: 364 RFEHLLN-GSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT 422 RFE + G K+ + +EFP + M Y S + +VP Y L ++ H+G Sbjct: 222 RFEFNQSLGQPEKIHNKLEFPQIIYMDRYMY----GSGSGSRQVP---YRLHAVLVHEGQ 274 Query: 423 VNEGHYIAFCKISGGQ-WFKFNDSMVSSISQEEVLKE 458 N GHY A+ Q W K+ND V+ S EEV ++ Sbjct: 275 ANAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERD 311 >5GJQ-x nrPDB Length = 494 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 99/444 (22%), Positives = 183/444 (41%), Gaps = 77/444 (17%) Query: 87 INSNNGLLFCFKCEDYIGNIDLINDAILAK--YWDDVCTKTMVPSMERRDGLSGLINMGS 144 I NG+ +G+ D + + AK + +D+ + + +ME GL N+G+ Sbjct: 61 IKIKNGMTLLM-----MGSADALPEEPSAKTVFVEDMTEEQLASAMELP---CGLTNLGN 112 Query: 145 TCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQAS 204 TC+M++ +QC+ P ++ ++ + +R+ + S I L ++ + Sbjct: 113 TCYMNATVQCIRSVPE-LKDALKRYAG---ALRASGEMASAQY--ITAALRDLFDSMDKT 166 Query: 205 SSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSY-VLDLPNAKEV 263 SSS F+++ + Y QQDA+E W ++ + Q ++ + KE Sbjct: 167 SSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKET 226 Query: 264 S-----RANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTT-IDPFLDLSLDI-KDKKKL 316 A + + ++ F E+++ C + T + L LS I ++ K L Sbjct: 227 DSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYL 286 Query: 317 YECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGS-NRK 375 + L ++E K IK I +LP+ L +Q+ RF + S N K Sbjct: 287 FTGLKLRLQEEITK----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAK 342 Query: 376 LDDFIEFPTYLNMKNYC---------STKEKDKHSENGKV-------------------- 406 + ++FP L+M C S + K K E+ KV Sbjct: 343 VLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYE 402 Query: 407 -----PDI------IYELIGIVSHKG-TVNEGHYIAFCKISGGQWFKFNDSMVSSISQEE 454 DI Y+L +++H+G + + GHY+++ K +W KF+D VS ++ E+ Sbjct: 403 PFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPED 462 Query: 455 VLKEQ-------AYLLFYTIRQVN 471 +L+ AY+L Y R+V Sbjct: 463 ILRLSGGGDWHIAYVLLYGPRRVE 486 >5TXK-A nrPDB Length = 372 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 92/372 (24%), Positives = 147/372 (39%), Gaps = 72/372 (19%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GLIN+G+T +++SILQ L F RH + ++ NN S L + L Sbjct: 17 GKIGLINLGNTSYVNSILQALFMASDF-RHCVLRLTENN----------SQPLMTKLQWL 65 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQS-- 252 +G L Q + S L+ +W + +QQD E+ +++++++H+ Sbjct: 66 FGFLEHSQRPAISPEN--------FLSASW--TPWFSPGTQQDCSEYLKYLLDRLHEEEK 115 Query: 253 ------YVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDL 306 L ++ V +F G + + I C C N S + F DL Sbjct: 116 TGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSRE-EAFTDL 174 Query: 307 SLDI-----KDKKKLYECLDSFHKKEQLKDFN-YHCGECNSTQDAIKQLGIHKLPSVLVL 360 SL + + + + ++ F E+L N Y+C C S QDA K + + + P L+L Sbjct: 175 SLAFPPPGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLIL 234 Query: 361 QLKRFE-HLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSH 419 L RF L RK+ D + P L + G+ D+ +V Sbjct: 235 TLLRFSFDLRTMRRRKILDDVSIPLLLRLP---------LAGGRGQAYDLC---SVVVHS 282 Query: 420 KGTVNEGHYIAFCKISGG----------------QWFKFNDSMVSSISQEEVL------- 456 + GHY + + QW+ FND+ VS S E V Sbjct: 283 GVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFP 342 Query: 457 KEQAYLLFYTIR 468 K+ AY+LFY R Sbjct: 343 KDTAYVLFYRQR 354 >2AYN-A nrPDB Length = 404 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 89/391 (22%), Positives = 162/391 (41%), Gaps = 67/391 (17%) Query: 138 GLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 197 GL N+G+TC+M++ +QC+ P ++ ++ + +R+ + S I L Sbjct: 16 GLTNLGNTCYMNATVQCIRSVPE-LKDALKRYAG---ALRASGEMASAQY--ITAALRDL 69 Query: 198 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSY-VLD 256 ++ +SSS F+++ + Y QQDA+E W ++ + Q ++ Sbjct: 70 FDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIE 129 Query: 257 LPNAKEVS-----RANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTT-IDPFLDLSLDI 310 + KE A + + ++ F E+++ C + T + L LS I Sbjct: 130 DDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFI 189 Query: 311 -KDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLL 369 ++ K L+ L ++E K IK I +LP+ L +Q+ RF + Sbjct: 190 NQEVKYLFTGLKLRLQEEITK----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKE 245 Query: 370 NGS-NRKLDDFIEFPTYLNMKNYC---------STKEKDKHSENGKV------------- 406 S N K+ ++FP L+M C S + K K E+ KV Sbjct: 246 KESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSP 305 Query: 407 ------------PDI------IYELIGIVSHKG-TVNEGHYIAFCKISGGQWFKFNDSMV 447 DI Y+L +++H+G + + GHY+++ K +W KF+D V Sbjct: 306 QKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKV 365 Query: 448 SSISQEEVLKEQ-------AYLLFYTIRQVN 471 S ++ E++L+ AY+L Y R+V Sbjct: 366 SIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 396 >3IHP-A nrPDB Length = 854 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 74/321 (23%), Positives = 123/321 (38%), Gaps = 63/321 (19%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHS--NNCKVRSPDKCFSCALDKIVH 192 G +G+ N+G++C+++S++Q L P F R + ++ N P + FS + K+ H Sbjct: 343 GYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPT-DPTQDFSTQVAKLGH 401 Query: 193 ELYGALNTKQASSSSTSTNR------QTGFIYLLTCAW--KINQNLAGYSQQDAHEFWQF 244 L +K S Q G + A K + + QQDA EF+ Sbjct: 402 GLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLH 461 Query: 245 IINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKT-TIDPF 303 +IN + + N + N VF +E I C + T +D Sbjct: 462 LINMVER-------NCRSSENPNE---------VFRFLVEEKIKCLATEKVKYTQRVDYI 505 Query: 304 LDLSLDI--------------------KDKKKLYE----------CLDSFHKKEQLKDFN 333 + L + + ++K L E CL+++ EQ+ DF Sbjct: 506 MQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDFW 565 Query: 334 YHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCS 393 + S A+K P LV+Q+K+F L+ +KLD IE P L++ Sbjct: 566 STALQAKSV--AVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRG 623 Query: 394 TKEKDKHSENGKVPDIIYELI 414 T + E +PDI L+ Sbjct: 624 TGLQPGEEE---LPDIAPPLV 641 >3JCR-V nrPDB Length = 565 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 95/462 (20%), Positives = 178/462 (38%), Gaps = 89/462 (19%) Query: 57 TFMCLQCG--FCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAI- 113 + CL CG F G SH HS Q H +N + +C N ++I+ ++ Sbjct: 133 AYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLP-----DNYEIIDSSLE 187 Query: 114 -LAKYWDDVCTKTMVPSMERR-------------DGLSGLINMGSTCFMSSILQCLIHNP 159 + TK + +++++ G+ GL N+ + + +++LQ L + P Sbjct: 188 DITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVP 247 Query: 160 YFIRHSMSQIHSNNCKVRSPDKCFSCA--LDKIVHELYGALNTKQASSSSTSTNRQTGFI 217 + + + + N K D F +++ +L+ N K S Sbjct: 248 PLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQA----- 302 Query: 218 YLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHT 277 ++ C+ K Q Q D +F + +N +H + K+ + IV Sbjct: 303 -VVLCSKKTFQIT---KQGDGVDFLSWFLNALHSALG-----------GTKKKKKTIVTD 347 Query: 278 VFEGSLE---SSIVCPGCQNNSKTTI------------DPFLDLSLDI------KDKKK- 315 VF+GS+ + P K + F+ L+LD+ KD+K+ Sbjct: 348 VFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQ 407 Query: 316 -------LYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHL 368 L+ L F+ + + Y ++ +K+ + KLP L+ +KRF Sbjct: 408 LIIPQVPLFNILAKFNGITEKEYKTY-------KENFLKRFQLTKLPPYLIFCIKRFTKN 460 Query: 369 LNGSNRKLDDFIEFP-TYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGH 427 N K + FP T ++++ Y S + + H + Y+LI + H G +EG Sbjct: 461 -NFFVEKNPTIVNFPITNVDLREYLSEEVQAVHK------NTTYDLIANIVHDGKPSEGS 513 Query: 428 Y-IAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIR 468 Y I G+W++ D V+ I + + +AY+ + R Sbjct: 514 YRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555 >1VJV-A nrPDB Length = 415 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 23/57 (40%), Positives = 38/57 (66%), Gaps = 3/57 (5%) Query: 402 ENGKVPDIIYELIGIVSHKGTVNE-GHYIAFCK--ISGGQWFKFNDSMVSSISQEEV 455 E G+ P +Y LIG+++H+G +E GHY AF + + +W+KFND VS + +E++ Sbjct: 337 EKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKI 393 >5MPC-8 nrPDB Length = 499 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 23/57 (40%), Positives = 38/57 (66%), Gaps = 3/57 (5%) Query: 402 ENGKVPDIIYELIGIVSHKGTVNE-GHYIAFCK--ISGGQWFKFNDSMVSSISQEEV 455 E G+ P +Y LIG+++H+G +E GHY AF + + +W+KFND VS + +E++ Sbjct: 421 EKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKI 477 >6H4H-A nrPDB Length = 560 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 115/271 (42%), Gaps = 40/271 (14%) Query: 132 RRDGLS-GLINMGSTCFMSSILQCLIHNPYFIR----HSMSQIHSNNCKVRSPDK--CFS 184 R DG GL N+G+TC+ S+++Q L P F R +S+ Q NC+ + + F Sbjct: 9 RVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFM 68 Query: 185 CALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQF 244 L + + G+ N K S+ + LL A++ ++ QQD EF Sbjct: 69 QELQYLFALMMGS-NRKFVDPSAA--------LDLLKGAFRSSEE----QQQDVSEFTHK 115 Query: 245 IINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVC---PGCQNNSKTTID 301 +++ + ++ L A V+ NK +V +F G+ + V P C N + Sbjct: 116 LLDWLEDAFQL----AVNVNSPRNKSENPMVQ-LFYGTFLTEGVREGKPFCNNET----- 165 Query: 302 PFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQ 361 F L + + L ECL+ + + + + + ++ KLP VL + Sbjct: 166 -FGQYPLQVNGYRNLDECLEG-----AMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFE 219 Query: 362 LKRFEHLLN-GSNRKLDDFIEFPTYLNMKNY 391 L RFE + G K+ + +EFP + M Y Sbjct: 220 LSRFEFNQSLGQPEKIHNKLEFPQIIYMDRY 250 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Query: 409 IIYELIGIVSHKGTVNEGHYIAFCKISGGQ-WFKFNDSMVSSISQEEVLKE 458 + Y L ++ H G N GHY A+ Q W K+ND V+ S EEV ++ Sbjct: 435 VPYRLHAVLVHDGQANAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERD 485 >6H4J-A nrPDB Length = 552 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 54/259 (20%), Positives = 111/259 (42%), Gaps = 27/259 (10%) Query: 138 GLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCK--VRSPDKCFSCALDKIVHELY 195 GL N+G+TC+ S+++Q L + F R ++ +N + R+ + + + + L+ Sbjct: 16 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 75 Query: 196 GAL-NTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYV 254 L TK+ + + +L A+K N + QQD EF +++ + ++ Sbjct: 76 ALLVGTKRKYVDPSRA------VEILKDAFKSNDS----QQQDVSEFTHKLLDWLEDAFQ 125 Query: 255 LDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKK 314 + + + N E +F G + V G + + F L + K Sbjct: 126 MKAEEETDEEKPKNPMVE-----LFYGRFLAVGVLEGKKFENTEM---FGQYPLQVNGFK 177 Query: 315 KLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFE-HLLNGSN 373 L+ECL++ + +++ + ++ + ++ +LP VL +L RFE + G Sbjct: 178 DLHECLEAAMIEGEIESLH-----SENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRP 232 Query: 374 RKLDDFIEFPTYLNMKNYC 392 K+ + +EFP L + Y Sbjct: 233 EKIHNKLEFPQVLYLDRYM 251 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 409 IIYELIGIVSHKGTVNEGHYIAFC-KISGGQWFKFNDSMVSSISQEEVLKE 458 + Y L ++ H+G N GHY A+ +W K+ND V+ S EE++++ Sbjct: 435 VPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRD 485 >5O71-A nrPDB Length = 716 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 61/290 (21%), Positives = 124/290 (42%), Gaps = 31/290 (10%) Query: 110 NDAILAKYWDDVCTKTMVPSMERRDGLS--GLINMGSTCFMSSILQCLIHNPYFIRHSMS 167 N A L + +V + P +R + GL N+G+TC+ S+++Q L + F R ++ Sbjct: 142 NKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLN 201 Query: 168 QIHSNNCK--VRSPDKCFSCALDKIVHELYGAL-NTKQASSSSTSTNRQTGFIYLLTCAW 224 +N + R+ + + + + L+ L TK+ + + +L A+ Sbjct: 202 YKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRA------VEILKDAF 255 Query: 225 KINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLE 284 K N + QQD EF +++ + ++ + + + N E +F G Sbjct: 256 KSNDS----QQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVE-----LFYGRFL 306 Query: 285 SSIVCPGCQ-NNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQ 343 + V G + N++ F L + K L+ECL++ + +++ + ++ Sbjct: 307 AVGVLEGKKFENTEM----FGQYPLQVNGFKDLHECLEAAMIEGEIESLH-----SENSG 357 Query: 344 DAIKQLGIHKLPSVLVLQLKRFE-HLLNGSNRKLDDFIEFPTYLNMKNYC 392 + ++ +LP VL +L RFE + G K+ + +EFP L + Y Sbjct: 358 KSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYM 407 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 409 IIYELIGIVSHKGTVNEGHYIAFC-KISGGQWFKFNDSMVSSISQEEVLKE 458 + Y L ++ H+G N GHY A+ +W K+ND V+ S EE++++ Sbjct: 591 VPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRD 641 >3C5K-A nrPDB Length = 109 Score = 34.7 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 7/92 (7%) Query: 35 VPKEKFLNTMKCGTCHEINSGATFMCLQCG--FCGCWNHSHFLSHSKQIGHIFGINSNNG 92 +P T CG C I ++CL C +CG + + H L H GH ++ + Sbjct: 16 IPAAGLDVTQPCGDCGTIQE--NWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDL 73 Query: 93 LLFCFKCEDYIGN---IDLINDAILAKYWDDV 121 +C+ C+ Y+ + +D+ N A K+ +D+ Sbjct: 74 SAWCYYCQAYVHHQALLDVKNIAHQNKFGEDM 105 >5G0F-A nrPDB Length = 110 Score = 33.9 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 3/60 (5%) Query: 49 CHEINSGA-TFMCLQCG--FCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGN 105 C E A ++CL C CG + + H ++H ++ GH ++ + ++C+ CE Y+ N Sbjct: 28 CEECGGEAENWICLFCYKVLCGRYVNQHMVTHGQESGHPVVLSFADLSVWCYACESYVHN 87 >1NI3-A nrPDB Length = 392 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 15/56 (26%), Positives = 27/56 (48%), Gaps = 2/56 (3%) Query: 128 PSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCF 183 P + G+ G+ N+G + F +I + ++ NP + + I KV PD+ F Sbjct: 17 PGNNLKTGIVGMPNVGKSTFFRAITKSVLGNP--ANYPYATIDPEEAKVAVPDERF 70 >2PVP-A nrPDB Length = 367 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 1/45 (2%) Query: 421 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQ-AYLLF 464 G V G ++ FC + GG F+ S+VS+I+ + VLK++ Y +F Sbjct: 13 GLVPRGSHMEFCVLFGGASFEHEISIVSAIALKGVLKDRIKYFIF 57 >5WLC-LP nrPDB Length = 440 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 6/95 (6%) Query: 334 YHCGECNSTQDAIKQLGIHKLPSVLVLQLKR--FEHLLNGSNRKLDDFIEFPTYLNMKNY 391 Y+ +C D + + G+ V ++ KR FEH LN ++D+I++ Y + N Sbjct: 6 YYLEQCIPEMDDLVEKGLFTKNEVSLIMKKRTDFEHRLNSRGSSINDYIKYINYESNVNK 65 Query: 392 CSTKEKDKHSENGKVPDI----IYELIGIVSHKGT 422 K + + K + I + IG + +GT Sbjct: 66 LRAKRCKRILQVKKTNSLSDWSIQQRIGFIYQRGT 100 >3AXH-A nrPDB Length = 589 Score = 28.1 bits (61), Expect = 8.3, Method: Compositional matrix adjust. Identities = 34/122 (27%), Positives = 52/122 (42%), Gaps = 13/122 (10%) Query: 353 KLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPT--YLNMK---NYCSTKEKDKHSENGKVP 407 KL SVL+ L ++ G +F +P Y +++ NY + KE+ H EN + Sbjct: 373 KLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEE--HGENSEEM 430 Query: 408 DIIYELIGIVS--HKGTV----NEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAY 461 E I ++S H T E F S WF NDS I+ E+ +K+ Sbjct: 431 KKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNS 490 Query: 462 LL 463 +L Sbjct: 491 VL 492 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4FIP-A nrPDB 677 0.0 2Y6E-A nrPDB 326 1e-89 6CPM-C nrPDB 304 9e-83 3JCR-V nrPDB 300 9e-82 5GJQ-x nrPDB 297 6e-81 6DGF-A nrPDB 291 5e-79 2GFO-A nrPDB 287 1e-77 3MTN-A nrPDB 285 2e-77 5L8W-A nrPDB 283 1e-76 5K1A-A nrPDB 282 3e-76 5L8H-A nrPDB 280 1e-75 5OHN-A nrPDB 279 1e-75 5OHK-A nrPDB 274 7e-74 5GVI-A nrPDB 270 8e-73 2AYN-A nrPDB 268 3e-72 6HEH-A nrPDB 265 3e-71 5CHV-A nrPDB 247 9e-66 5WCH-A nrPDB 243 2e-64 2F1Z-A nrPDB 241 5e-64 5J7T-A nrPDB 238 4e-63 5JTJ-A nrPDB 238 5e-63 5JTV-A nrPDB 236 1e-62 5TXK-A nrPDB 216 2e-56 6H4H-A nrPDB 201 6e-52 6H4J-A nrPDB 197 1e-50 3IHP-A nrPDB 193 2e-49 5MPC-8 nrPDB 117 1e-26 1VJV-A nrPDB 110 2e-24 Sequences not found previously or not previously below threshold: 5O71-A nrPDB 198 3e-51 4MSX-A nrPDB 76 2e-14 3WXF-A nrPDB 39 0.004 3C5K-A nrPDB 37 0.017 2VHF-A nrPDB 36 0.038 3BYN-A nrPDB 34 0.12 3OM6-A nrPDB 34 0.15 2UZG-A nrPDB 34 0.15 3LNB-A nrPDB 30 2.3 2I50-A nrPDB 30 2.7 2IO3-A nrPDB 30 3.1 4WUR-A nrPDB 29 6.6 5KO3-A nrPDB 28 7.6 >4FIP-A nrPDB Length = 476 Score = 677 bits (1746), Expect = 0.0, Method: Composition-based stats. Identities = 470/471 (99%), Positives = 471/471 (100%) Query: 1 MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC 60 MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC Sbjct: 6 MSICPHIQQVFQNEKSKDGVLKTCNAARYILNHSVPKEKFLNTMKCGTCHEINSGATFMC 65 Query: 61 LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD 120 LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD Sbjct: 66 LQCGFCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAILAKYWDD 125 Query: 121 VCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD 180 VCTKTMVPSMERRDGLSGLINMG+TCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD Sbjct: 126 VCTKTMVPSMERRDGLSGLINMGNTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPD 185 Query: 181 KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE 240 KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE Sbjct: 186 KCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHE 245 Query: 241 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI 300 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI Sbjct: 246 FWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTI 305 Query: 301 DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL 360 DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL Sbjct: 306 DPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVL 365 Query: 361 QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK 420 QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK Sbjct: 366 QLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHK 425 Query: 421 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN 471 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN Sbjct: 426 GTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQVN 476 >2Y6E-A nrPDB Length = 367 Score = 326 bits (835), Expect = 1e-89, Method: Composition-based stats. Identities = 102/378 (26%), Positives = 164/378 (43%), Gaps = 58/378 (15%) Query: 129 SMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALD 188 M + GL GL N+G+TCFM+S LQCL + + + + +P + Sbjct: 1 GMHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNP-----LGMK 55 Query: 189 KIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQ 248 + E Y L + S + T + +GY QQD+ E F+++ Sbjct: 56 GEIAEAYAELIKQMWSGRDAHVAPRM----FKTQVGRFAPQFSGYQQQDSQELLAFLLDG 111 Query: 249 IHQSY----------------VLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGC 292 +H+ D AKE + + + ++ F G +S++VCP C Sbjct: 112 LHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPEC 171 Query: 293 QNNSKTTIDPFLDLSLDIKDKK-------------------KLYECLDSFHKKEQLKDFN 333 S T DPF L+L + KK L +C++ F E L + + Sbjct: 172 AKVS-VTFDPFCYLTLPLPLKKDRVMEGPMLQPQKKKKTTVALRDCIELFTTMETLGEHD 230 Query: 334 -YHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTY-LNMKNY 391 ++C C Q A K+ + LP +LV+ LKRF + + KLD +EFP LNM + Sbjct: 231 PWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRD-KLDTVVEFPIRGLNMSEF 289 Query: 392 CSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKIS-GGQWFKFNDSMVSSI 450 N +Y+LI + +H G + GHY A+ K G+W+ F+DS VS Sbjct: 290 VC---------NLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLA 340 Query: 451 SQEEVLKEQAYLLFYTIR 468 S+++++ + AY+LFY R Sbjct: 341 SEDQIVTKAAYVLFYQRR 358 >6CPM-C nrPDB Length = 349 Score = 304 bits (777), Expect = 9e-83, Method: Composition-based stats. Identities = 105/359 (29%), Positives = 167/359 (46%), Gaps = 52/359 (14%) Query: 133 RDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVH 192 + GL GL N+G+TCFM+S +QCL + P + ++ + +P + + Sbjct: 16 QPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNP-----LGMRGEIA 70 Query: 193 ELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQS 252 + Y L KQ S S F T + +GY QQD E F+++ +H+ Sbjct: 71 KSYAEL-IKQMWSGKFSYVTPRAF---KTQVGRFAPQFSGYQQQDCQELLAFLLDGLHED 126 Query: 253 Y----------------VLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNS 296 D A+E + K+ + I+ +F G +S++VCP C S Sbjct: 127 LNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKIS 186 Query: 297 KTTIDPFLDLSLDIKDKK----KLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGI 351 T DPF L+L + K KL +C++ F KE+L + ++C C Q A K+L + Sbjct: 187 -VTFDPFCYLTLPLPMPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDL 245 Query: 352 HKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTY-LNMKNYCSTKEKDKHSENGKVPDII 410 LP VLV+ LKRF + + KLD ++FP L+M Sbjct: 246 WSLPPVLVVHLKRFSYSRYMRD-KLDTLVDFPINDLDMSG------------------CR 286 Query: 411 YELIGIVSHKGTVNEGHYIAFCKIS-GGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIR 468 Y LI + +H G + GHY AF K G+W+ F+DS VS+ S+++++ + AY+LFY + Sbjct: 287 YNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQ 345 >3JCR-V nrPDB Length = 565 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 93/462 (20%), Positives = 173/462 (37%), Gaps = 89/462 (19%) Query: 57 TFMCLQCG--FCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYIGNIDLINDAI- 113 + CL CG F G SH HS Q H +N + +C N ++I+ ++ Sbjct: 133 AYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLP-----DNYEIIDSSLE 187 Query: 114 -LAKYWDDVCTKTMVPSMERR-------------DGLSGLINMGSTCFMSSILQCLIHNP 159 + TK + +++++ G+ GL N+ + + +++LQ L + P Sbjct: 188 DITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVP 247 Query: 160 YFIRHSMSQIHSNNCKVRSPDKCFSCA--LDKIVHELYGALNTKQASSSSTSTNRQTGFI 217 + + + + N K D F +++ +L+ N K S Sbjct: 248 PLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQA----- 302 Query: 218 YLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHT 277 ++ C+ K Q Q D +F + +N +H + + IV Sbjct: 303 -VVLCSKKTFQIT---KQGDGVDFLSWFLNALHSALGGTKKK-----------KKTIVTD 347 Query: 278 VFEGS---LESSIVCPGCQNNSKTT------------IDPFLDLSLDIK------DKKK- 315 VF+GS + P K F+ L+LD+ D+K+ Sbjct: 348 VFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQ 407 Query: 316 -------LYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHL 368 L+ L F+ + + Y ++ +K+ + KLP L+ +KRF Sbjct: 408 LIIPQVPLFNILAKFNGITEKEYKTY-------KENFLKRFQLTKLPPYLIFCIKRFTKN 460 Query: 369 LNGSNRKLDDFIEFP-TYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGH 427 N K + FP T ++++ Y S + + H + Y+LI + H G +EG Sbjct: 461 -NFFVEKNPTIVNFPITNVDLREYLSEEVQAVHK------NTTYDLIANIVHDGKPSEGS 513 Query: 428 Y-IAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIR 468 Y I G+W++ D V+ I + + +AY+ + R Sbjct: 514 YRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRR 555 >5GJQ-x nrPDB Length = 494 Score = 297 bits (761), Expect = 6e-81, Method: Composition-based stats. Identities = 97/444 (21%), Positives = 179/444 (40%), Gaps = 77/444 (17%) Query: 87 INSNNGLLFCFKCEDYIGNIDLINDAILAK--YWDDVCTKTMVPSMERRDGLSGLINMGS 144 I NG+ +G+ D + + AK + +D+ + + +ME GL N+G+ Sbjct: 61 IKIKNGMTLLM-----MGSADALPEEPSAKTVFVEDMTEEQLASAMELP---CGLTNLGN 112 Query: 145 TCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQAS 204 TC+M++ +QC+ P + ++ + +R+ + S I L ++ + Sbjct: 113 TCYMNATVQCIRSVPEL-KDALKRYAG---ALRASGEMASAQY--ITAALRDLFDSMDKT 166 Query: 205 SSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSY-VLDLPNAKEV 263 SSS F+++ + Y QQDA+E W ++ + Q ++ + KE Sbjct: 167 SSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKET 226 Query: 264 S-----RANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTT-IDPFLDLSLDIKDK-KKL 316 A + + ++ F E+++ C + T + L LS I + K L Sbjct: 227 DSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYL 286 Query: 317 YECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGS-NRK 375 + L ++E K IK I +LP+ L +Q+ RF + S N K Sbjct: 287 FTGLKLRLQEEITK----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAK 342 Query: 376 LDDFIEFPTYLNMKNYC---------STKEKDKHSENGKVPDI----------------- 409 + ++FP L+M C S + K K E+ KV Sbjct: 343 VLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYE 402 Query: 410 --------------IYELIGIVSHKG-TVNEGHYIAFCKISGGQWFKFNDSMVSSISQEE 454 Y+L +++H+G + + GHY+++ K +W KF+D VS ++ E+ Sbjct: 403 PFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPED 462 Query: 455 VLKEQ-------AYLLFYTIRQVN 471 +L+ AY+L Y R+V Sbjct: 463 ILRLSGGGDWHIAYVLLYGPRRVE 486 >6DGF-A nrPDB Length = 370 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 105/356 (29%), Positives = 161/356 (45%), Gaps = 45/356 (12%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 GL+GL N+G+TCFM+SILQCL + + + +++ + S A +V E Sbjct: 30 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDL------HHGSNAHTALVEEF 83 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQ--- 251 + T SS N T + GY+QQDA EF +F+++ +H Sbjct: 84 AKLIQTIWTSS----PNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVN 139 Query: 252 -------------SYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKT 298 ++ D +++ R ++ + + +F G L+SS+ C C S T Sbjct: 140 RVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCS-T 198 Query: 299 TIDPFLDLSLDIKDKK----KLYECLDSFHKKEQLK-DFNYHCGECNSTQDAIKQLGIHK 353 DPF DLSL I + L +C+ F K++ L D C C + IK+ I + Sbjct: 199 VFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQR 258 Query: 354 LPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTY-LNMKNYCSTKEKDKHSENGKVPDIIYE 412 P +LVL LKRF KL F+ FP L+++ + S +Y Sbjct: 259 FPKILVLHLKRFS-ESRIRTSKLTTFVNFPLRDLDLREFASENTNHA----------VYN 307 Query: 413 LIGIVSHKGTVNEGHYIAFCK-ISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTI 467 L + +H GT GHY A+C+ G+W FNDS V+ +S +V AYLLFY + Sbjct: 308 LYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYEL 363 >2GFO-A nrPDB Length = 396 Score = 287 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 110/359 (30%), Positives = 174/359 (48%), Gaps = 49/359 (13%) Query: 134 DGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHE 193 L+GL N+G+TC+M+SILQCL + P+ ++ + NC ++ V E Sbjct: 60 PALTGLRNLGNTCYMNSILQCLCNAPH-----LADYFNRNCYQDDINRSNLLGHKGEVAE 114 Query: 194 LYG----ALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQI 249 +G AL T Q S + T KIN AGYSQQD+ E F+++ + Sbjct: 115 EFGIIMKALWTGQYRYISPKDFKIT--------IGKINDQFAGYSQQDSQELLLFLMDGL 166 Query: 250 HQ----------------SYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQ 293 H+ ++ D A+ + + + E I+ +F+G +S++ C C Sbjct: 167 HEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCH 226 Query: 294 NNSKTTIDPFLDLSLDIKDKK--KLYECLDSFHKKEQLKDFN-YHCGECNSTQDAIKQLG 350 S T + F+ LSL + L +CL F K+E+L D N ++C C + +D++K++ Sbjct: 227 KKS-RTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIE 285 Query: 351 IHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTY-LNMKNYCSTKEKDKHSENGKVPDI 409 I KLP VL++ LKRF + +KL ++FP L++ Y + + Sbjct: 286 IWKLPPVLLVHLKRFSYDGRWK-QKLQTSVDFPLENLDLSQYVIGPKNNLKK-------- 336 Query: 410 IYELIGIVSHKGTVNEGHYIAFCKISGGQ-WFKFNDSMVSSISQEEVLKEQAYLLFYTI 467 Y L + +H G ++ GHY A+CK + Q WFKF+D VS IS V AY+LFYT Sbjct: 337 -YNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTS 394 >3MTN-A nrPDB Length = 373 Score = 285 bits (729), Expect = 2e-77, Method: Composition-based stats. Identities = 98/374 (26%), Positives = 163/374 (43%), Gaps = 63/374 (16%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GL N+G+TCF++++LQCL + + P + L + ++ Sbjct: 21 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV----PGGGRAQELTEAFADV 76 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIH---- 250 GAL + + T + F K + +GYSQQDA EF + ++ ++H Sbjct: 77 IGALWHPDSCEAVNPTRFRAVF-------QKYVPSFSGYSQQDAQEFLKLLMERLHLEIN 129 Query: 251 ---------------------------QSYVLDLPNAKEVSRANNKQCECIVHTVFEGSL 283 + + D A + + ++ + + +F G L Sbjct: 130 RRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQL 189 Query: 284 ESSIVCPGCQNNSKTTIDPFLDLSLDIKDKK------KLYECLDSFHKKEQLKDFNYH-C 336 +S + C C S TT + F DLSL I K L +C + F K+E+L+ N C Sbjct: 190 KSCLKCQACGYRS-TTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVC 248 Query: 337 GECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFP-TYLNMKNYCSTK 395 C + K+L + + P +LVL L RF GS +K ++FP L++ ++ S K Sbjct: 249 DRCRQKTRSTKKLTVQRFPRILVLHLNRFSASR-GSIKKSSVGVDFPLQRLSLGDFASDK 307 Query: 396 EKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEV 455 +Y+L + +H G+V+ GHY A C+ G W +NDS VS +S+ +V Sbjct: 308 AGSP----------VYQLYALCNHSGSVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQV 356 Query: 456 LKEQAYLLFYTIRQ 469 + Y+LFY + Q Sbjct: 357 ASSEGYVLFYQLMQ 370 >5L8W-A nrPDB Length = 376 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 103/358 (28%), Positives = 162/358 (45%), Gaps = 51/358 (14%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELY 195 GL+N G+TC+ +S+LQ L YF R ++ + + R + +C + +L+ Sbjct: 44 YFGLVNFGNTCYCNSVLQAL----YFCRPFREKVLAYKSQPRKKESLLTC-----LADLF 94 Query: 196 GALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVL 255 ++ T++ + +T K N+ Y QQDAHEF +++N I Sbjct: 95 HSIATQKKKVGVIPPKK------FITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQE 148 Query: 256 DLPNAKEVSR----------ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLD 305 + K+ R N+ VH +F+G+L + C C+ S D FLD Sbjct: 149 ERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDED-FLD 207 Query: 306 LSLDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKR 364 LS+D++ + CL F E L ++ Y+C EC S Q+A K++ + KLP +L L LKR Sbjct: 208 LSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKR 267 Query: 365 FEH-LLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT- 422 F++ KL + FP L + N S + PD +Y+L+ +V H G+ Sbjct: 268 FKYMDQLHRYTKLSYRVVFPLELRLFN---------TSGDATNPDRMYDLVAVVVHCGSG 318 Query: 423 VNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVL------------KEQAYLLFYTIR 468 N GHYIA K S W F+D +V I + + E Y+LFY R Sbjct: 319 PNRGHYIAIVK-SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 375 >5K1A-A nrPDB Length = 331 Score = 282 bits (720), Expect = 3e-76, Method: Composition-based stats. Identities = 103/356 (28%), Positives = 162/356 (45%), Gaps = 51/356 (14%) Query: 138 GLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 197 GL+N G+TC+ +S+LQ L YF R ++ + + R + +C + +L+ + Sbjct: 1 GLVNFGNTCYCNSVLQAL----YFCRPFREKVLAYKSQPRKKESLLTC-----LADLFHS 51 Query: 198 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDL 257 + T++ + +T K N+ Y QQDAHEF +++N I + Sbjct: 52 IATQKKKVGVIPPKK------FITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEER 105 Query: 258 PNAKEVSR----------ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLS 307 K+ R N+ VH +F+G+L + C C+ S D FLDLS Sbjct: 106 KQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDED-FLDLS 164 Query: 308 LDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFE 366 +D++ + CL F E L ++ Y+C EC S Q+A K++ + KLP +L L LKRF+ Sbjct: 165 VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFK 224 Query: 367 H-LLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT-VN 424 + KL + FP L + N S + PD +Y+L+ +V H G+ N Sbjct: 225 YMDQLHRYTKLSYRVVFPLELRLFN---------TSGDATNPDRMYDLVAVVVHCGSGPN 275 Query: 425 EGHYIAFCKISGGQWFKFNDSMVSSISQEEVL------------KEQAYLLFYTIR 468 GHYIA K S W F+D +V I + + E Y+LFY R Sbjct: 276 RGHYIAIVK-SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 330 >5L8H-A nrPDB Length = 359 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 100/359 (27%), Positives = 161/359 (44%), Gaps = 51/359 (14%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELY 195 GL+N G+TC+++S+LQ L YF R + + + + + +C + +L+ Sbjct: 27 YFGLVNFGNTCYVNSVLQAL----YFCRPFRENVLAYKAQQKKKENLLTC-----LADLF 77 Query: 196 GALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVL 255 ++ T++ + ++ K N Y QQDAHEF +++N I Sbjct: 78 HSIATQKKKVGVIPPKK------FISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQE 131 Query: 256 DLPNAKEVSR----------ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLD 305 + K+ + NNK VH +F+G+L + C C+ S D FLD Sbjct: 132 EKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDED-FLD 190 Query: 306 LSLDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKR 364 LS+D++ + CL F E L + Y+C C S Q+A K++ + KLP +L L LKR Sbjct: 191 LSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKR 250 Query: 365 FEHLLNGSN-RKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT- 422 F+++ KL + FP L + N S + D +Y+L+ +V H G+ Sbjct: 251 FKYMEQLRRYTKLSYRVVFPLELRLFN---------TSSDAVNLDRMYDLVAVVVHCGSG 301 Query: 423 VNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVL------------KEQAYLLFYTIRQ 469 N GHYI K S G W F+D +V I + + E Y+LFY R+ Sbjct: 302 PNRGHYITIVK-SHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE 359 >5OHN-A nrPDB Length = 370 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 93/384 (24%), Positives = 150/384 (39%), Gaps = 72/384 (18%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIRH--SMSQIHSNNCKVRSPDKCFSCALDKIVHE 193 + GL+N+G+TCFM+S+LQ L P FIR + +S + K P + + + Sbjct: 6 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQK-EPPSHQYLSLTLLHLLK 64 Query: 194 LYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQS- 252 Q + + L W+I + + +QDAHE + I + + Sbjct: 65 ALSC----QEVTDDEVLDASCLLDVLRMYRWQI----SSFEEQDAHELFHVITSSLEDER 116 Query: 253 -------YVLDLPNAKEVSRANNKQCECIV-------------HTVFEGSLESSIVCPGC 292 ++ D+ + ++ S KQ C F G L S++VC C Sbjct: 117 DRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHC 176 Query: 293 QNNSKTTIDPFLDLSLDIKDKK-----KLYECLDSFHKKEQLKDFNYHCGECNSTQD--- 344 ++ S D F LSL I L CL F E ++D C C + Sbjct: 177 EHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVV--CDNCTKIEAKGT 234 Query: 345 ------------AIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYC 392 +KQL + KLP L + L+R +G+ K + ++F L+M Y Sbjct: 235 LNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLDMDEY- 293 Query: 393 STKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFCKIS---------GGQWFKFN 443 K+ N ++ L+ +V H G ++ GH++ + + QW + Sbjct: 294 ------KYHSNAST--YLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVS 345 Query: 444 DSMVSSISQEEVLKEQAYLLFYTI 467 D V S +EVL AYLLFY Sbjct: 346 DDTVRKASLQEVLSSSAYLLFYER 369 >5OHK-A nrPDB Length = 336 Score = 274 bits (700), Expect = 7e-74, Method: Composition-based stats. Identities = 90/363 (24%), Positives = 145/363 (39%), Gaps = 64/363 (17%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIRH--SMSQIHSNNCKVRSPDKCFSCALDKIVHE 193 + GL+N+G+TCFM+S+LQ L P FIR + +S + K P + + + Sbjct: 6 VPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQK-EPPSHQYLSLTLLHLLK 64 Query: 194 LYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSY 253 Q + + L W+I + + +QDAHE + I + + Sbjct: 65 ALSC----QEVTDDEVLDASCLLDVLRMYRWQI----SSFEEQDAHELFHVITSSLEDE- 115 Query: 254 VLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDK 313 ++ S ++ K F G L S++VC C++ S D F LSL I Sbjct: 116 -------RDGSGSHWKS-----QHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAA 163 Query: 314 K-----KLYECLDSFHKKEQLKDFNYHCGECNSTQD---------------AIKQLGIHK 353 L CL F E ++D C C + +KQL + K Sbjct: 164 TWGHPLTLDHCLHHFISSESVRDVV--CDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGK 221 Query: 354 LPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYEL 413 LP L + L+R +G+ K + ++F L+M Y K+ N ++ L Sbjct: 222 LPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLSMDEY-------KYHSNAST--YLFRL 272 Query: 414 IGIVSHKGTVNEGHYIAFCKIS---------GGQWFKFNDSMVSSISQEEVLKEQAYLLF 464 + +V H G ++ GH++ + + QW +D V S +EVL AYLLF Sbjct: 273 MAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLF 332 Query: 465 YTI 467 Y Sbjct: 333 YER 335 >5GVI-A nrPDB Length = 444 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 99/440 (22%), Positives = 155/440 (35%), Gaps = 115/440 (26%) Query: 136 LSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELY 195 + GL+N+G+T FM+S+LQ L P FIR + S N R + L + + +L Sbjct: 6 VPGLLNLGNTAFMNSLLQGLAACPSFIRW-LEDFTSQNSADRERTE-RETQLSRSLMQLL 63 Query: 196 GALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQ---- 251 AL SS + LL +++ + +QDAHE + + + + + Sbjct: 64 KAL-----SSHVPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELFHVLTSSLEEEQER 118 Query: 252 ----SYVLDLPNAKEVSRANNKQCECI-------------VHTVFEGSLESSIVCPGCQN 294 +++ D+ ++ + K C F G L S + C C+ Sbjct: 119 QPRVAHLFDMQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRHPFHGRLTSYMACKRCEQ 178 Query: 295 NSKTTIDPFLDLSLDIKDKK-----KLYECLDSFHKKEQLKDFNYHCGECNSTQD----- 344 S D F LSL I + L +CL F E +K+ C C Q Sbjct: 179 QSPVHYDSFDSLSLSIPSIQWGRPVTLDQCLQHFISSETIKE--VECENCTKQQAGELVN 236 Query: 345 ----------AIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNY--- 391 +KQL + KLP L + L+R GS K + ++F YL++ Y Sbjct: 237 GEVLESQRTTFVKQLKLGKLPQCLCIHLQRLTWSKEGSPIKRQEHVQFTEYLSLDRYKHC 296 Query: 392 ----------------CSTKEKDKHSENG------------------------------- 404 S KDK NG Sbjct: 297 SAAQSQQKTSRTNKAKASADPKDKAIANGVDSEHCNNNKPQSNGTFPSVFLHSPGLSSQL 356 Query: 405 ------KVPDIIYELIGIVSHKGTVNEGHYIAFCKISGG---------QWFKFNDSMVSS 449 + ++ L ++ H G ++ GH+I + + QW +D V Sbjct: 357 NLTYDYSTSEYLFRLTAVLVHHGDMHSGHFITYRRCPAAPRGTSPFSSQWLWVSDDSVRK 416 Query: 450 ISQEEVLKEQAYLLFYTIRQ 469 S +EVL AYLLFY Q Sbjct: 417 ASLQEVLSSSAYLLFYERMQ 436 >2AYN-A nrPDB Length = 404 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 90/409 (22%), Positives = 165/409 (40%), Gaps = 70/409 (17%) Query: 120 DVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSP 179 D+ + + +ME GL N+G+TC+M++ +QC+ P + ++ + +R+ Sbjct: 1 DMTEEQLASAMELP---CGLTNLGNTCYMNATVQCIRSVPEL-KDALKRYAG---ALRAS 53 Query: 180 DKCFSCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAH 239 + S I L ++ +SSS F+++ + Y QQDA+ Sbjct: 54 GEMASAQY--ITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDAN 111 Query: 240 EFWQFIINQIHQSY-VLDLPNAKEVS-----RANNKQCECIVHTVFEGSLESSIVCPGCQ 293 E W ++ + Q ++ + KE A + + ++ F E+++ C + Sbjct: 112 ECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESE 171 Query: 294 NNSKTT-IDPFLDLSLDIKDK-KKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGI 351 T + L LS I + K L+ L ++E K IK I Sbjct: 172 EEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK----QSPTLQRNALYIKSSKI 227 Query: 352 HKLPSVLVLQLKRFEHLLNGS-NRKLDDFIEFPTYLNMKNYC---------STKEKDKHS 401 +LP+ L +Q+ RF + S N K+ ++FP L+M C S + K K Sbjct: 228 SRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDL 287 Query: 402 ENGKVPDI-------------------------------IYELIGIVSHKG-TVNEGHYI 429 E+ KV Y+L +++H+G + + GHY+ Sbjct: 288 EDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYV 347 Query: 430 AFCKISGGQWFKFNDSMVSSISQEEVLKEQ-------AYLLFYTIRQVN 471 ++ K +W KF+D VS ++ E++L+ AY+L Y R+V Sbjct: 348 SWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 396 >6HEH-A nrPDB Length = 382 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 87/351 (24%), Positives = 148/351 (42%), Gaps = 50/351 (14%) Query: 132 RRDGLS-GLINMGSTCFMSSILQCLIHNPYFIR----HSMSQIHSNNCKVRSPDK--CFS 184 R DG GL N+G+TC+ S+++Q L P F R +S+ Q NC+ + + F Sbjct: 9 RVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFM 68 Query: 185 CALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQF 244 L + + G+ N K S+ + LL A++ ++ QQD EF Sbjct: 69 QELQYLFALMMGS-NRKFVDPSAA--------LDLLKGAFRSSEE----QQQDVSEFTHK 115 Query: 245 IINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFL 304 +++ + ++ L + +++ N +F G+ + V G + + F Sbjct: 116 LLDWLEDAFQLAVNVNSPRNKSENPMV-----QLFYGTFLTEGVREGKPFCNN---ETFG 167 Query: 305 DLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKR 364 L + + L ECL+ + + + + + ++ KLP VL +L R Sbjct: 168 QYPLQVNGYRNLDECLEG-----AMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFELSR 222 Query: 365 FEHLLN-GSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTV 423 FE + G K+ + +EFP + M Y S + +VP Y L ++ H+G Sbjct: 223 FEFNQSLGQPEKIHNKLEFPQIIYMDRYMY----GSGSGSRQVP---YRLHAVLVHEGQA 275 Query: 424 NEGHYIAFCKISGGQ-WFKFNDSMVSSISQEEVLKE--------QAYLLFY 465 N GHY A+ Q W K+ND V+ S EEV ++ AY L Y Sbjct: 276 NAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMY 326 >5CHV-A nrPDB Length = 323 Score = 247 bits (630), Expect = 9e-66, Method: Composition-based stats. Identities = 90/355 (25%), Positives = 146/355 (41%), Gaps = 53/355 (14%) Query: 131 ERRDGLSGLINMGSTCFMSSILQCLIHNPYFI--RHSMSQIHSNNCKVRSPDKCFSCALD 188 + GL GL N+G TC ++S+LQ + N F ++ S + RS L+ Sbjct: 1 DSPHGLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLE 60 Query: 189 KIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQ 248 K+ +++Q + T L+ C K N L + Q DA + + I N Sbjct: 61 KMQ-------DSRQKAVLPT---------ELVQCLQKYNVPL--FVQHDAAQLYLTIWN- 101 Query: 249 IHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSL 308 + + + D + + +F + S++C GC S L LSL Sbjct: 102 LTKDQITDTDLTER------------LQGLFTIWTQESLICVGCTAESSRR-SKLLTLSL 148 Query: 309 DIKDK-----KKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLK 363 + DK K L + L F + ++L + C C + L + LP L + L Sbjct: 149 PLFDKDAKPLKTLEDALRCFVQPKELASSDMCCESCGEKTPWKQVLKLTHLPQTLTIHLM 208 Query: 364 RFEHLLNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTV 423 RF N K+ + FP L+ T+E + + +I YEL +++H G Sbjct: 209 RFSAR-NSRTEKICHSVNFPQSLDFSQVLPTEED--LGDTKEQSEIHYELFAVIAHVGMA 265 Query: 424 NEGHYIAFCKIS-GGQWFKFNDSMVSSISQEEV----------LKEQAYLLFYTI 467 + GHY A+ + G+WF FNDS V ++ ++V +E AYLL YT Sbjct: 266 DFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQCTYGNHRYRWRETAYLLVYTK 320 >5WCH-A nrPDB Length = 421 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 94/420 (22%), Positives = 159/420 (37%), Gaps = 100/420 (23%) Query: 133 RDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSM---------------SQIHSNNCKVR 177 G GL N G+TC+M+S++Q L P + + N V Sbjct: 4 PKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVD 63 Query: 178 SPDKCF-----------SCALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWK- 225 D F + G L Q + +R Y+ WK Sbjct: 64 PRDDVFGYPQQFEDKPALSKTEDRAAYNIGVLRHLQVIFGHLAASRLQ--YYVPRGFWKQ 121 Query: 226 ---INQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGS 282 + + Q DA EF+ +++ + ++ ++ V GS Sbjct: 122 FRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGH-------------PAMLSKVLGGS 168 Query: 283 LESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFN-YHCGECNS 341 +C GC + + + F L++DI++ + L + L+ + K + L+ N YHC +CN Sbjct: 169 FADQKICQGCPHRYECE-ESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNK 227 Query: 342 TQDAIKQLGIHKLPSVLVLQLKRFEHLLNGS-NRKLDDFIEFPTYLNMKNYCSTK----- 395 D +K+L I KLP VL +QLKRF++ K +D+ EFP L+M+ Y Sbjct: 228 KVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLE 287 Query: 396 -----------EKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFC--KISG----GQ 438 ++ + SE+ Y L+G++ H G + GHY ++ + G + Sbjct: 288 GDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNR 347 Query: 439 WFKFNDSMVS--SISQEEVLKEQ----------------------------AYLLFYTIR 468 W+KF+D V+ + +E +K Q AY+LFY Sbjct: 348 WYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERM 407 >2F1Z-A nrPDB Length = 522 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 98/414 (23%), Positives = 163/414 (39%), Gaps = 64/414 (15%) Query: 76 SHSKQIGHIFGINSNNGLLFCFKCEDYIGNID--LINDAILAK--YWDDVCTKTMVPSME 131 S S++I H+F N+ F + + + I+D + + + + Sbjct: 111 SFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSK 170 Query: 132 RRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIV 191 + G GL N G+TC+M+S+LQ L F ++ + K AL ++ Sbjct: 171 KHTGYVGLKNQGATCYMNSLLQTLF----FTNQLRKAVYMMPTEGDDSSKSVPLALQRVF 226 Query: 192 HELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQ 251 +EL Q S T + T + W + L + Q D E + +++ + Sbjct: 227 YEL-------QHSDKPVGTKKLT-----KSFGW---ETLDSFMQHDVQELCRVLLDNVE- 270 Query: 252 SYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIK 311 ++ E + +F G + S I C S D + D+ L IK Sbjct: 271 ------------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYY-DIQLSIK 317 Query: 312 DKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH-LLN 370 KK ++E + EQL N + + Q+A K + LP VL LQL RF + Sbjct: 318 GKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQT 377 Query: 371 GSNRKLDDFIEFPTYLNMKNYCS-TKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYI 429 N K++D EFP L + + T KD + Y L ++ H G + GHY+ Sbjct: 378 DQNIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGGHYV 428 Query: 430 AFCKISG-GQWFKFNDSMVSSISQEEVLK---------------EQAYLLFYTI 467 + G G+W KF+D +VS ++EE ++ AY+L Y Sbjct: 429 VYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIR 482 >5J7T-A nrPDB Length = 671 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 89/351 (25%), Positives = 141/351 (40%), Gaps = 60/351 (17%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GL N G+TC+M+S+LQ L F ++ + K AL ++ +EL Sbjct: 2 GYVGLKNQGATCYMNSLLQTLF----FTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYEL 57 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYV 254 Q S T + T + W + L + Q D E + +++ + Sbjct: 58 -------QHSDKPVGTKKLTK-----SFGW---ETLDSFMQHDVQELCRVLLDNVE---- 98 Query: 255 LDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKK 314 ++ E + +F G + S I C S D + D+ L IK KK Sbjct: 99 ---------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYY-DIQLSIKGKK 148 Query: 315 KLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH-LLNGSN 373 ++E + EQL N + + Q+A K + LP VL LQL RF + N Sbjct: 149 NIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQN 208 Query: 374 RKLDDFIEFPTYLNMKNYCS-TKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGHYIAFC 432 K++D EFP L + + T KD + Y L ++ H G + GHY+ + Sbjct: 209 IKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGGHYVVYL 259 Query: 433 KISG-GQWFKFNDSMVSSISQEEVLK---------------EQAYLLFYTI 467 G G+W KF+D +VS ++EE ++ AY+L Y Sbjct: 260 NPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIR 310 >5JTJ-A nrPDB Length = 387 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 89/357 (24%), Positives = 143/357 (40%), Gaps = 60/357 (16%) Query: 129 SMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALD 188 ++ G GL N G+TC+M+S+LQ L F ++ + K AL Sbjct: 15 GSKKHTGYVGLKNQGATCYMNSLLQTLF----FTNQLRKAVYMMPTEGDDSSKSVPLALQ 70 Query: 189 KIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQ 248 ++ +EL Q S T + T + W + L + Q D E + +++ Sbjct: 71 RVFYEL-------QHSDKPVGTKKLT-----KSFGW---ETLDSFMQHDVQELCRVLLDN 115 Query: 249 IHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSL 308 + ++ E + +F G + S I C S D + D+ L Sbjct: 116 VE-------------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYY-DIQL 161 Query: 309 DIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH- 367 IK KK ++E + EQL N + + Q+A K + LP VL LQL RF + Sbjct: 162 SIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYD 221 Query: 368 LLNGSNRKLDDFIEFPTYLNMKNYCS-TKEKDKHSENGKVPDIIYELIGIVSHKGTVNEG 426 N K++D EFP L + + T KD + Y L ++ H G + G Sbjct: 222 PQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGG 272 Query: 427 HYIAFCKISG-GQWFKFNDSMVSSISQEEVLK---------------EQAYLLFYTI 467 HY+ + G G+W KF+D +VS ++EE ++ AY+L Y Sbjct: 273 HYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIR 329 >5JTV-A nrPDB Length = 594 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 89/357 (24%), Positives = 143/357 (40%), Gaps = 60/357 (16%) Query: 129 SMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALD 188 ++ G GL N G+TC+M+S+LQ L F ++ + K AL Sbjct: 15 GSKKHTGYVGLKNQGATCYMNSLLQTLF----FTNQLRKAVYMMPTEGDDSSKSVPLALQ 70 Query: 189 KIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQ 248 ++ +EL Q S T + T + W + L + Q D E + +++ Sbjct: 71 RVFYEL-------QHSDKPVGTKKLTK-----SFGW---ETLDSFMQHDVQELCRVLLDN 115 Query: 249 IHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSL 308 + ++ E + +F G + S I C S D + D+ L Sbjct: 116 VE-------------NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYY-DIQL 161 Query: 309 DIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEH- 367 IK KK ++E + EQL N + + Q+A K + LP VL LQL RF + Sbjct: 162 SIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYD 221 Query: 368 LLNGSNRKLDDFIEFPTYLNMKNYCS-TKEKDKHSENGKVPDIIYELIGIVSHKGTVNEG 426 N K++D EFP L + + T KD + Y L ++ H G + G Sbjct: 222 PQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPAN---------YILHAVLVHSGDNHGG 272 Query: 427 HYIAFCKISG-GQWFKFNDSMVSSISQEEVLK---------------EQAYLLFYTI 467 HY+ + G G+W KF+D +VS ++EE ++ AY+L Y Sbjct: 273 HYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIR 329 >5TXK-A nrPDB Length = 372 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 90/372 (24%), Positives = 145/372 (38%), Gaps = 72/372 (19%) Query: 135 GLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHEL 194 G GLIN+G+T +++SILQ L F RH + ++ NN S L + L Sbjct: 17 GKIGLINLGNTSYVNSILQALFMASDF-RHCVLRLTENN----------SQPLMTKLQWL 65 Query: 195 YGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQS-- 252 +G L Q + S L+ +W + +QQD E+ +++++++H+ Sbjct: 66 FGFLEHSQRPAISPEN--------FLSASW--TPWFSPGTQQDCSEYLKYLLDRLHEEEK 115 Query: 253 ------YVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDL 306 L ++ V +F G + + I C C N S + F DL Sbjct: 116 TGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSS-REEAFTDL 174 Query: 307 SLDIK-----DKKKLYECLDSFHKKEQLKDFN-YHCGECNSTQDAIKQLGIHKLPSVLVL 360 SL + + + ++ F E+L N Y+C C S QDA K + + + P L+L Sbjct: 175 SLAFPPPGSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLIL 234 Query: 361 QLKRFEHL-LNGSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSH 419 L RF RK+ D + P L + G+ D+ ++ Sbjct: 235 TLLRFSFDLRTMRRRKILDDVSIPLLLRL---------PLAGGRGQAYDLCSVVVHSGV- 284 Query: 420 KGTVNEGHYIAFCKISG----------------GQWFKFNDSMVSSISQEEVL------- 456 + GHY + + QW+ FND+ VS S E V Sbjct: 285 --SSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFP 342 Query: 457 KEQAYLLFYTIR 468 K+ AY+LFY R Sbjct: 343 KDTAYVLFYRQR 354 >6H4H-A nrPDB Length = 560 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 61/270 (22%), Positives = 112/270 (41%), Gaps = 34/270 (12%) Query: 132 RRDGLS-GLINMGSTCFMSSILQCLIHNPYFIR----HSMSQIHSNNCKVRSPDK--CFS 184 R DG GL N+G+TC+ S+++Q L P F R +S+ Q NC+ + + F Sbjct: 9 RVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFM 68 Query: 185 CALDKIVHELYGALNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQF 244 L + + G+ N K S+ + LL A++ ++ QQD EF Sbjct: 69 QELQYLFALMMGS-NRKFVDPSAA--------LDLLKGAFRSSEE----QQQDVSEFTHK 115 Query: 245 IINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFL 304 +++ + ++ L + +++ N +F G+ + V G + + F Sbjct: 116 LLDWLEDAFQLAVNVNSPRNKSENPMV-----QLFYGTFLTEGVREGKPFCNN---ETFG 167 Query: 305 DLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKR 364 L + + L ECL+ + + + + + ++ KLP VL +L R Sbjct: 168 QYPLQVNGYRNLDECLEG-----AMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFELSR 222 Query: 365 FEHLLN-GSNRKLDDFIEFPTYLNMKNYCS 393 FE + G K+ + +EFP + M Y Sbjct: 223 FEFNQSLGQPEKIHNKLEFPQIIYMDRYMY 252 Score = 71.3 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 9/64 (14%) Query: 411 YELIGIVSHKGTVNEGHYIAFCKISGGQ-WFKFNDSMVSSISQEEVLKE--------QAY 461 Y L ++ H G N GHY A+ Q W K+ND V+ S EEV ++ AY Sbjct: 437 YRLHAVLVHDGQANAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVSAY 496 Query: 462 LLFY 465 L Y Sbjct: 497 CLMY 500 >5O71-A nrPDB Length = 716 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 115/282 (40%), Gaps = 29/282 (10%) Query: 115 AKYWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNC 174 + W D ++ GL N+G+TC+ S+++Q L + F R ++ +N Sbjct: 151 TEVWRDSRNPYDRKRQDKAP--VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNA 208 Query: 175 K--VRSPDKCFSCALDKIVHELYGAL-NTKQASSSSTSTNRQTGFIYLLTCAWKINQNLA 231 + R+ + + + + L+ L TK+ + + +L A+K N + Sbjct: 209 QDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRA------VEILKDAFKSNDS-- 260 Query: 232 GYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPG 291 QQD EF +++ + ++ + + + N E +F G + V G Sbjct: 261 --QQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVE-----LFYGRFLAVGVLEG 313 Query: 292 CQNNSKTTIDPFLDLSLDIKDKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGI 351 + + + F L + K L+ECL++ + +++ ++ + ++ Sbjct: 314 KKFENT---EMFGQYPLQVNGFKDLHECLEAAMIEGEIES-----LHSENSGKSGQEHWF 365 Query: 352 HKLPSVLVLQLKRFEHLLN-GSNRKLDDFIEFPTYLNMKNYC 392 +LP VL +L RFE G K+ + +EFP L + Y Sbjct: 366 TELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYM 407 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 9/73 (12%) Query: 402 ENGKVPDIIYELIGIVSHKGTVNEGHYIAFC-KISGGQWFKFNDSMVSSISQEEVLKE-- 458 + + + Y L ++ H+G N GHY A+ +W K+ND V+ S EE++++ Sbjct: 584 SDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSF 643 Query: 459 ------QAYLLFY 465 AY L Y Sbjct: 644 GGYRNASAYCLMY 656 >6H4J-A nrPDB Length = 552 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 110/260 (42%), Gaps = 27/260 (10%) Query: 137 SGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCK--VRSPDKCFSCALDKIVHEL 194 GL N+G+TC+ S+++Q L + F R ++ +N + R+ + + + + L Sbjct: 15 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 74 Query: 195 YGAL-NTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSY 253 + L TK+ + + +L A+K N + QQD EF +++ + ++ Sbjct: 75 FALLVGTKRKYVDPSRA------VEILKDAFKSNDS----QQQDVSEFTHKLLDWLEDAF 124 Query: 254 VLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDK 313 + + + N E +F G + V G + + + F L + Sbjct: 125 QMKAEEETDEEKPKNPMVE-----LFYGRFLAVGVLEGKKFENT---EMFGQYPLQVNGF 176 Query: 314 KKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLN-GS 372 K L+ECL++ + +++ ++ + ++ +LP VL +L RFE G Sbjct: 177 KDLHECLEAAMIEGEIES-----LHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGR 231 Query: 373 NRKLDDFIEFPTYLNMKNYC 392 K+ + +EFP L + Y Sbjct: 232 PEKIHNKLEFPQVLYLDRYM 251 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 35/73 (47%), Gaps = 9/73 (12%) Query: 402 ENGKVPDIIYELIGIVSHKGTVNEGHYIAFC-KISGGQWFKFNDSMVSSISQEEVLKE-- 458 + + + Y L ++ H+G N GHY A+ +W K+ND V+ S EE++++ Sbjct: 428 SDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSF 487 Query: 459 ------QAYLLFY 465 AY L Y Sbjct: 488 GGYRNASAYCLMY 500 >3IHP-A nrPDB Length = 854 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 123/322 (38%), Gaps = 63/322 (19%) Query: 134 DGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHS--NNCKVRSPDKCFSCALDKIV 191 G +G+ N+G++C+++S++Q L P F R + ++ N P + FS + K+ Sbjct: 342 PGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTD-PTQDFSTQVAKLG 400 Query: 192 HELYGALNTKQASSSSTSTNR------QTGFIYLLTCA--WKINQNLAGYSQQDAHEFWQ 243 H L +K S Q G + A K + + QQDA EF+ Sbjct: 401 HGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFL 460 Query: 244 FIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQNNSKT-TIDP 302 +IN + + N + N VF +E I C + T +D Sbjct: 461 HLINMVER-------NCRSSENPNE---------VFRFLVEEKIKCLATEKVKYTQRVDY 504 Query: 303 FLDLSLDI--------------------KDKKKLYE----------CLDSFHKKEQLKDF 332 + L + + ++K L E CL+++ EQ+ DF Sbjct: 505 IMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGAPEQVDDF 564 Query: 333 NYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFPTYLNMKNYC 392 + S A+K P LV+Q+K+F L+ +KLD IE P L++ Sbjct: 565 WSTALQAKSV--AVKTTRFASFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLR 622 Query: 393 STKEKDKHSENGKVPDIIYELI 414 T + ++PDI L+ Sbjct: 623 GTGLQP---GEEELPDIAPPLV 641 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 4/58 (6%) Query: 411 YELIGIVSHKG-TVNEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTI 467 Y+L +SH G + GHY+ K G+W +ND V + E+ K+ Y+ FY Sbjct: 797 YQLFAFISHMGTSTMCGHYVCHIK-KEGRWVIYNDQKVCAS--EKPPKDLGYIYFYQR 851 >5MPC-8 nrPDB Length = 499 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 71/431 (16%), Positives = 128/431 (29%), Gaps = 107/431 (24%) Query: 117 YWDDVCTKTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKV 176 + +D+ + V + G NMG+TC++++ LQ L ++ S V Sbjct: 91 FIEDLAPEQQVQQFAQLP--VGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQG--V 146 Query: 177 RSPDKCFSCALDKIVHELYGALNTKQ-ASSSSTSTNRQTGFIYLLTCAWKINQNLAG-YS 234 + +IV E+ Q S S + + + G Y Sbjct: 147 SNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYK 206 Query: 235 QQDAHEFWQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQN 294 QQDA E + + + + + F +++I N Sbjct: 207 QQDAEELFTQLFHSMSIVFGDKFSED------------------FRIQFKTTIKDTANDN 248 Query: 295 -NSKTTIDPFLDLSLDIKDKKK-LYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIH 352 + + L I + L ++ K + + + I Sbjct: 249 DITVKENESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEK----KIS 304 Query: 353 KLPSVLVLQLKRFEHLLNGSNR-KLDDFIEFPTYLNM-----KNYCSTKEK--------- 397 +LP L +Q RF + + + K+ + FP L++ Y + K K Sbjct: 305 RLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVE 364 Query: 398 ----------------DKHSENGKVPDIIYELIGIVS----------------------- 418 SEN P YE ++ Sbjct: 365 KEKNEKEREIKRRKFDPSSSENVMTPREQYETQVALNESEKDQWLEEYKKHFPPNLEKGE 424 Query: 419 -------------HKGTVN-EGHYIAFCKI--SGGQWFKFNDSMVSSISQEEV------- 455 H+G + GHY AF + +W+KFND VS + +E++ Sbjct: 425 NPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGG 484 Query: 456 LKEQAYLLFYT 466 + A +L Y Sbjct: 485 ESDSALILMYK 495 >1VJV-A nrPDB Length = 415 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 70/424 (16%), Positives = 124/424 (29%), Gaps = 107/424 (25%) Query: 124 KTMVPSMERRDGLSGLINMGSTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCF 183 + V + G NMG+TC++++ LQ L ++ S V + Sbjct: 14 EQQVQQFAQLP--VGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQG--VSNSGAQD 69 Query: 184 SCALDKIVHELYGALNTKQ-ASSSSTSTNRQTGFIYLLTCAWKINQNLAG-YSQQDAHEF 241 +IV E+ Q S S + + + G Y QQDA E Sbjct: 70 EEIHKQIVIEMKRCFENLQNKSFKSVLPVVLLNTLRKCYPQFAERDSQGGFYKQQDAEEL 129 Query: 242 WQFIINQIHQSYVLDLPNAKEVSRANNKQCECIVHTVFEGSLESSIVCPGCQN-NSKTTI 300 + + + + + F +++I N + Sbjct: 130 FTQLFHSMSIVFGDKFSED------------------FRIQFKTTIKDTANDNDITVKEN 171 Query: 301 DPFLDLSLDIKDKKK-LYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLV 359 + L I + L ++ K + + + I +LP L Sbjct: 172 ESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEK----KISRLPKFLT 227 Query: 360 LQLKRFEHLLNGSNR-KLDDFIEFPTYLNM-----KNYCSTKEK---------------- 397 +Q RF + + + K+ + FP L++ Y + K K Sbjct: 228 VQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKE 287 Query: 398 ---------DKHSENGKVPDIIYELIGIVS------------------------------ 418 SEN P YE ++ Sbjct: 288 REIKRRKFDPSSSENVMTPREQYETQVALNESEKDQWLEEYKKHFPPNLEKGENPSCVYN 347 Query: 419 ------HKGTVN-EGHYIAFCKI--SGGQWFKFNDSMVSSISQEEV-------LKEQAYL 462 H+G + GHY AF + +W+KFND VS + +E++ + A + Sbjct: 348 LIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGESDSALI 407 Query: 463 LFYT 466 L Y Sbjct: 408 LMYK 411 >4MSX-A nrPDB Length = 482 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 64/463 (13%), Positives = 126/463 (27%), Gaps = 105/463 (22%) Query: 49 CHEINSGATFMCLQCG--FCGCWNHSHFLSHSKQIGHIFGINSNNGLLFCFKCEDYI--- 103 C ++ + CL CG + G S HS H +N + + I Sbjct: 83 CITLSPLNVYCCLVCGHYYQGRHEKSPAFIHSIDENHHVFLNLTSLKFYMLPQNVQILHD 142 Query: 104 GNIDLINDAILAKYWDDVCTKTMVPSMERR----------DGLSGLINMGSTCFMSSILQ 153 G + L+N A Y + R+ +G G N + + S+L Sbjct: 143 GEVQLLNSIKFAAY--PTYCPKDLEDFPRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLL 200 Query: 154 CLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQASSSST----- 208 + H H + N + F L V +++ K S Sbjct: 201 LISHMVPVRDHFLLNHFDNQGE-------FIKRLSICVKKIWSPKLFKHHLSVDDFVSYL 253 Query: 209 ---STNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDLPNAKEVSR 265 L W N+ + + + I+N + Sbjct: 254 KVREGLNLNPIDPRLFLLWLFNKICSSSND------LKSILN-----HSCKGKVKIAKVE 302 Query: 266 ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKLYEC-----L 320 + E + V + PF L+LD+ + + L Sbjct: 303 NKPEASESVTGKVI--------------------VKPFWVLTLDLPEFSPFEDGNSVDDL 342 Query: 321 DSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNGSNR-KLDDF 379 + + L F + + +LP L+ RF+ + + + Sbjct: 343 PQINITKLLTKFTKS-----RSSSTSTVFELTRLPQFLIFHFNRFDRNSDHPVKNRNQTL 397 Query: 380 IEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSH--------KGTVNEG----H 427 +EF + L ++ + Y L V H G G H Sbjct: 398 VEFSSEL------------------EILHVKYRLKANVVHVVIKQPSTDGNAFNGDEKSH 439 Query: 428 YIAFCK-ISGGQWFKFNDSMVSSISQEEVLKEQAYLLFYTIRQ 469 +I +W + + + E + ++ ++ + ++ Sbjct: 440 WITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE 482 >3WXF-A nrPDB Length = 312 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 22/98 (22%), Positives = 36/98 (36%), Gaps = 19/98 (19%) Query: 349 LGIHKLPSVLVLQLKRFEHLLNGSNRKLDDFIEFP-TYLNMKNYCSTKEKDKHSENGKVP 407 L + PS L++Q+ RF N K+ FP L++ + + P Sbjct: 164 LKFAEAPSCLIIQMPRFGKDFKMFN-KI-----FPSLELDITDLLDDTPLEGG------P 211 Query: 408 DIIYELIGIVSHKGTVNEGHYIAFCKISGGQ--WFKFN 443 EL ++ + HY+AF K W F+ Sbjct: 212 HQQMELFAVLC----IETSHYVAFVKYGSADSAWLFFD 245 >3C5K-A nrPDB Length = 109 Score = 37.1 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 43/92 (46%), Gaps = 7/92 (7%) Query: 35 VPKEKFLNTMKCGTCHEINSGATFMCLQCG--FCGCWNHSHFLSHSKQIGHIFGINSNNG 92 +P T CG C I ++CL C +CG + + H L H GH ++ + Sbjct: 16 IPAAGLDVTQPCGDCGTIQEN--WVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDL 73 Query: 93 LLFCFKCEDYIGNIDLINDAILA---KYWDDV 121 +C+ C+ Y+ + L++ +A K+ +D+ Sbjct: 74 SAWCYYCQAYVHHQALLDVKNIAHQNKFGEDM 105 >2VHF-A nrPDB Length = 374 Score = 35.9 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 49/318 (15%), Positives = 102/318 (32%), Gaps = 45/318 (14%) Query: 144 STCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGALNTKQA 203 ++C++ S L CL + + + N + +S + + E+ L Sbjct: 17 NSCYLDSTLFCLFAFSSVLDTVLLRPKEKN-----DVEYYSETQELLRTEIVNPL----R 67 Query: 204 SSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFII-NQIHQSYVLDLPNAKE 262 + +L + + ++D EF + + + +L + +A + Sbjct: 68 IYGYVCATKIMKLRKILEKVEAASGFTS--EEKDPEEFLNILFHHILRVEPLLKIRSAGQ 125 Query: 263 VS----------RANNKQCECIVHTVFEGSL-ESSIVCPGCQNNSKTTIDPFLDLSLDIK 311 N K + + E S S++ + + F D K Sbjct: 126 KVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGK---DFK 182 Query: 312 DKKKLYECLDSFHKKEQLKDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFEHLLNG 371 KK++ L+ + + L+D C C + + P + ++K+F N Sbjct: 183 LFKKIFPSLEL-NITDLLEDTPRQCRICGGLAMYECR-ECYDDPDISAGKIKQFCKTCNT 240 Query: 372 S----NRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGTVNEGH 427 ++L+ P L D +G +P EL ++ + H Sbjct: 241 QVHLHPKRLNHKYN-PVSL------PKDLPDWDWRHGCIPCQNMELFAVLC----IETSH 289 Query: 428 YIAFCK--ISGGQWFKFN 443 Y+AF K W F+ Sbjct: 290 YVAFVKYGKDDSAWLFFD 307 >3BYN-A nrPDB Length = 473 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 16/30 (53%) Query: 436 GGQWFKFNDSMVSSISQEEVLKEQAYLLFY 465 G+W+ F DS S ++ + + Y+L Y Sbjct: 350 NGKWYLFTDSRGSKMTIDGITSNDIYMLGY 379 >3OM6-A nrPDB Length = 456 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 18/32 (56%) Query: 434 ISGGQWFKFNDSMVSSISQEEVLKEQAYLLFY 465 G+W+ F DS S ++ + + ++ Y+L Y Sbjct: 330 KKDGKWYLFTDSRGSKMTIDGIGQDDVYMLGY 361 >2UZG-A nrPDB Length = 97 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 27/63 (42%), Gaps = 6/63 (9%) Query: 47 GTCHE--INSGATFMCLQ--CGFCGCWNHS--HFLSHSKQIGHIFGINSNNGLLFCFKCE 100 GTC + + + CL+ C + GC H HS++ H +N ++C+ C Sbjct: 26 GTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACS 85 Query: 101 DYI 103 + Sbjct: 86 KEV 88 >3LNB-A nrPDB Length = 309 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 16/29 (55%) Query: 38 EKFLNTMKCGTCHEINSGATFMCLQCGFC 66 EK L + G C+E+NS + + CGF Sbjct: 88 EKLLIQKRGGLCYELNSLLYYFLMDCGFQ 116 >2I50-A nrPDB Length = 126 Score = 29.7 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 29/54 (53%), Gaps = 6/54 (11%) Query: 56 ATFMCLQCGFCGCWNHS---HFLSH---SKQIGHIFGINSNNGLLFCFKCEDYI 103 + ++CL+CG GC +S H L H + H ++ +N ++C+ C++ + Sbjct: 53 SVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 106 >2IO3-A nrPDB Length = 232 Score = 29.7 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 25/186 (13%), Positives = 50/186 (26%), Gaps = 16/186 (8%) Query: 152 LQCLIH----NPYFIRHSMSQIHSNNCKVRSP----------DKCFSCALDKIVHELYGA 197 +Q L + N I M+ + N K P K S + G Sbjct: 45 IQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGV 104 Query: 198 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIHQSYVLDL 257 +Q + + ++ K + L Q H + ++ + Sbjct: 105 NLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDS-MGQKGHRICEILLQYLQDESKTKR 163 Query: 258 PNAKEVSR-ANNKQCECIVHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLSLDIKDKKKL 316 + + ++ + GS C S+ F + + KK + Sbjct: 164 NSDLNLLEWTHHSMKPHEIPQQLNGSDSGMFTCKYADYISRDKPITFTQHQMPLFRKKMV 223 Query: 317 YECLDS 322 +E L Sbjct: 224 WEILHQ 229 >4WUR-A nrPDB Length = 326 Score = 28.6 bits (62), Expect = 6.6, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 20/56 (35%), Gaps = 2/56 (3%) Query: 398 DKHSENGKVPDIIYELIGIVSHKG-TVNEGHYIAFCKISGGQWFKFNDSMVSSISQ 452 +E + + +G GHY+ ++ GG KF+ VS S Sbjct: 254 GTPNEKLVTTSTAPDFVAFNVFQGIETAVGHYVH-ARLKGGLILKFDSGTVSKTSD 308 >5KO3-A nrPDB Length = 257 Score = 28.2 bits (61), Expect = 7.6, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 2/54 (3%) Query: 400 HSENGKVPDIIYELIGIVSHKG-TVNEGHYIAFCKISGGQWFKFNDSMVSSISQ 452 +E + + +G GHY+ ++ GG KF+ VS S Sbjct: 188 PNEKLVTTSTAPDFVAFNVFQGIETAVGHYVH-ARLKGGLILKFDSGTVSKTSD 240 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.125 0.350 Lambda K H 0.267 0.0385 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,295,405 Number of Sequences: 36641 Number of extensions: 662137 Number of successful extensions: 1965 Number of sequences better than 10.0: 42 Number of HSP's better than 10.0 without gapping: 65 Number of HSP's successfully gapped in prelim test: 18 Number of HSP's that attempted gapping in prelim test: 1592 Number of HSP's gapped (non-prelim): 114 length of query: 471 length of database: 10,336,785 effective HSP length: 101 effective length of query: 370 effective length of database: 6,636,044 effective search space: 2455336280 effective search space used: 2455336280 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.2 bits)