BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P50086 (228 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1WG0-A nrPDB 471 e-133 4NIK-A nrPDB 114 3e-26 2DWZ-A nrPDB 112 1e-25 5AQ7-A nrPDB 73 1e-13 5AQ9-A nrPDB 72 2e-13 5H76-A nrPDB 72 2e-13 5AQA-A nrPDB 72 2e-13 5JHQ-A nrPDB 70 6e-13 5AQB-A nrPDB 70 8e-13 5GP7-A nrPDB 68 4e-12 6MWQ-A nrPDB 65 2e-11 5HKP-A nrPDB 65 3e-11 5MIO-C nrPDB 61 3e-10 5ET1-A nrPDB 60 1e-09 6FES-A nrPDB 59 1e-09 4Z68-A nrPDB 59 2e-09 3B7B-A nrPDB 58 3e-09 6BY9-A nrPDB 58 3e-09 5CBO-A nrPDB 58 3e-09 4O1O-A nrPDB 57 4e-09 3EU9-A nrPDB 55 2e-08 6AUN-A nrPDB 53 1e-07 4OAU-C nrPDB 52 2e-07 1G3N-B nrPDB 50 6e-07 4OT9-A nrPDB 48 4e-06 6EMK-G nrPDB 47 9e-06 3LJN-A nrPDB 45 4e-05 5D68-A nrPDB 44 5e-05 1BD8-A nrPDB 43 9e-05 2KXP-C nrPDB 42 2e-04 1BLX-B nrPDB 42 2e-04 3EHQ-A nrPDB 40 6e-04 3T9K-A nrPDB 36 0.011 4BSZ-B nrPDB 36 0.015 6DJS-A nrPDB 36 0.017 6CUD-A nrPDB 36 0.018 3DEO-A nrPDB 35 0.022 3UI2-A nrPDB 35 0.025 3ZKJ-A nrPDB 35 0.039 2RFA-A nrPDB 34 0.040 2NYJ-A nrPDB 34 0.056 6BBJ-A nrPDB 34 0.064 6DMR-A nrPDB 33 0.077 3W9G-A nrPDB 33 0.084 6BOA-A nrPDB 33 0.088 5IRX-A nrPDB 33 0.095 6C8G-A nrPDB 33 0.13 5U0K-A nrPDB 32 0.25 6E2G-A nrPDB 32 0.27 2ETB-A nrPDB 32 0.32 6CV9-A nrPDB 31 0.37 5HI9-A nrPDB 31 0.42 6OO7-A nrPDB 31 0.45 2F37-A nrPDB 31 0.47 6BO5-A nrPDB 31 0.48 5AN8-A nrPDB 30 0.98 5UQE-A nrPDB 28 3.3 5U0J-A nrPDB 28 3.7 3T6Q-C nrPDB 27 5.5 3M7O-A nrPDB 27 5.8 5I1T-A nrPDB 27 7.1 >1WG0-A nrPDB Length = 243 Score = 471 bits (1211), Expect = e-133, Method: Compositional matrix adjust. Identities = 228/228 (100%), Positives = 228/228 (100%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME Sbjct: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF Sbjct: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH Sbjct: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV 228 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV Sbjct: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV 228 >4NIK-A nrPDB Length = 230 Score = 114 bits (286), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 73/194 (37%), Positives = 106/194 (54%), Gaps = 8/194 (4%) Query: 17 KVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPF 76 +++E + + SL + DQD R LHW+ S EI FLL VN DD+GW+P Sbjct: 25 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVN---DKDDAGWSPL 81 Query: 77 HIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIK 136 HIA S G E+VK+L + + +N + G T LH A K E++ L+E GA+ K Sbjct: 82 HIAASAGRDEIVKALLGKGAQ--VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 139 Query: 137 DKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 D + +HRAA+ G+LK+I +L K++ N QD +G TPL A E + A LLV + Sbjct: 140 DHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 198 Query: 197 YGAEYDLVDNKGAK 210 + Y ++NK K Sbjct: 199 GASIY--IENKEEK 210 Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/152 (32%), Positives = 74/152 (48%), Gaps = 8/152 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL K + + +Q+G PLH++ S HEI LL N + Sbjct: 80 PLHIAASAGRDEIVKALL-GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 138 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D+ + T H A + GNL+++ L K N +G T LHLA ++ E ++ Sbjct: 139 KDHYE---ATAMHRAAAKGNLKMIHILL--YYKASTNIQDTEGNTPLHLACDEERVEEAK 193 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLI 156 L+ GAS+ I++K + PL A G L LI Sbjct: 194 LLVSQGASIYIENKEEKTPLQVAK--GGLGLI 223 >2DWZ-A nrPDB Length = 231 Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 73/210 (34%), Positives = 110/210 (52%), Gaps = 8/210 (3%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 +SN + + +++E + + SL + DQD R LHW+ S EI FLL Sbjct: 5 VSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 VN DD+GW+P HIA S G E+VK+L + +N + G T LH A K Sbjct: 65 PVN---DKDDAGWSPLHIAASAGRDEIVKALLVK--GAHVNAVNQNGCTPLHYAASKNRH 119 Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 E++ L+E GA+ KD ++ +HRAA+ G+LK++ +L K++ N QD +G TPL Sbjct: 120 EIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILL-FYKASTNIQDTEGNTPLHL 178 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210 A E + A LV + + Y ++NK K Sbjct: 179 ACDEERVEEAKFLVTQGASIY--IENKEEK 206 Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 53/152 (34%), Positives = 75/152 (49%), Gaps = 8/152 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL K + + +Q+G PLH++ S HEI LL N + Sbjct: 76 PLHIAASAGRDEIVKALL-VKGAHVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D+ D T H A + GNL++V L K N +G T LHLA ++ E ++ Sbjct: 135 KDHYD---ATAMHRAAAKGNLKMVHILL--FYKASTNIQDTEGNTPLHLACDEERVEEAK 189 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLI 156 FL+ GAS+ I++K + PL A G L LI Sbjct: 190 FLVTQGASIYIENKEEKTPLQVAK--GGLGLI 219 >5AQ7-A nrPDB Length = 418 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 51/141 (36%), Positives = 74/141 (52%), Gaps = 6/141 (4%) Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHL 113 LL+ +VN D++G+TP H+A G+L +V+ L D+N +G T LHL Sbjct: 32 ILLANGADVN---TADETGFTPLHLAAWEGHLGIVEVLLKN--GADVNANDERGHTPLHL 86 Query: 114 AVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 A E+ + L++NGA V D PLH AA G +++E+L G V+ QDK Sbjct: 87 AAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGAD-VDAQDKF 145 Query: 174 GWTPLFHALAEGHGDAAVLLV 194 G PL+ A +GH + A LV Sbjct: 146 GKRPLWLAADQGHAEIAAKLV 166 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 41/120 (34%), Positives = 61/120 (50%), Gaps = 7/120 (5%) Query: 33 DQDGRIPLHWSVSFQAH-EITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 D+ G PLH + +++ H I LL +VN +D + G TP H+A G+LE+V+ L Sbjct: 44 DETGFTPLHLA-AWEGHLGIVEVLLKNGADVNAND---ERGHTPLHLAAYTGHLEIVEVL 99 Query: 92 YDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVG 151 +N G LHLA + E+ + L++ GA V +DKF + PL AA G Sbjct: 100 LKN--GAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQG 157 Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 2/112 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N G T LHLA + + + L++NGA V D+ PLH AA G L+++E+ Sbjct: 39 DVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEV 98 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210 L G + VN D G PL A G+ + +L+ K GA+ D D G + Sbjct: 99 LLKNG-AGVNATDVIGTAPLHLAAMWGYKEIVEVLL-KAGADVDAQDKFGKR 148 Score = 43.5 bits (101), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 10/102 (9%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +GKK E ++ L+ NGA V D+ PLH AA G L ++E+L G Sbjct: 14 LGKKLLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGAD- 72 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 VN D++G TPL A GH + +L+ K GA + D G Sbjct: 73 VNANDERGHTPLHLAAYTGHLEIVEVLL-KNGAGVNATDVIG 113 >5AQ9-A nrPDB Length = 422 Score = 72.0 bits (175), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 56/158 (35%), Positives = 79/158 (50%), Gaps = 7/158 (4%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 GR L + + Q E+ L++ +VN D++G TP H+A G+LE+V+ L Sbjct: 15 GRKLLEAARAGQDDEV-RILMANGADVN---AADNTGTTPLHLAAYSGHLEIVEVLLKHG 70 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D + + G T LHLA E+ + L++NGA V D PLH AA G L++ Sbjct: 71 ADVDASDVF--GYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEI 128 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 +E+L G VN QDK G TP A G+ D LL Sbjct: 129 VEVLLKHGAD-VNAQDKFGKTPFDLADDNGNDDVGTLL 165 Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 41/116 (35%), Positives = 62/116 (53%), Gaps = 7/116 (6%) Query: 33 DQDGRIPLHWSVSFQAH-EITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 D G PLH + ++ H EI LL +V D D G+TP H+A G+LE+V+ L Sbjct: 44 DNTGTTPLHLA-AYSGHLEIVEVLLKHGADV---DASDVFGYTPLHLAAYWGHLEIVEVL 99 Query: 92 YDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRA 147 D+N + + G+T LHLA + E+ + L+++GA V +DKF + P A Sbjct: 100 LKN--GADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGADVNAQDKFGKTPFDLA 153 Score = 60.8 bits (146), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 43/117 (36%), Positives = 61/117 (52%), Gaps = 2/117 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N N G T LHLA E+ + L+++GA V D F PLH AA G L+++E+ Sbjct: 39 DVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEV 98 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 L G VN D G TPL A G+ + +L+ K+GA+ + D G D+A Sbjct: 99 LLKNGAD-VNAMDSDGMTPLHLAAKWGYLEIVEVLL-KHGADVNAQDKFGKTPFDLA 153 Score = 45.4 bits (106), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/102 (33%), Positives = 52/102 (50%), Gaps = 10/102 (9%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +G+K E ++ L+ NGA V D PLH AA G L+++E+L G Sbjct: 14 LGRKLLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGAD- 72 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 V+ D G+TPL A GH + +L+ K GA+ + +D+ G Sbjct: 73 VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDG 113 >5H76-A nrPDB Length = 201 Score = 72.0 bits (175), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/159 (34%), Positives = 81/159 (50%), Gaps = 8/159 (5%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 GR L + + Q E+ L++ +VN D++G TP H+A G+LE+V+ L Sbjct: 7 GRKLLEAARAGQDDEV-RILMANGADVN---AADNTGTTPLHLAAYSGHLEIVEVLLKHG 62 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D + + G T LHLA E+ + L++NGA V D PLH AA G L++ Sbjct: 63 ADVDASDVF--GYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEI 120 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLV 194 +E+L L AVN QDK G T ++ G+ D A +L Sbjct: 121 VEVL--LKHGAVNAQDKFGKTAFDISIDNGNEDLAQILA 157 Score = 60.1 bits (144), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 41/128 (32%), Positives = 64/128 (50%), Gaps = 6/128 (4%) Query: 33 DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLY 92 D G PLH + EI LL +V D D G+TP H+A G+LE+V+ L Sbjct: 36 DNTGTTPLHLAAYSGHLEIVEVLLKHGADV---DASDVFGYTPLHLAAYWGHLEIVEVLL 92 Query: 93 DRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGS 152 D+N + + G+T LHLA + E+ + L+++GA V +DKF + + G+ Sbjct: 93 KN--GADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA-VNAQDKFGKTAFDISIDNGN 149 Query: 153 LKLIELLC 160 L ++L Sbjct: 150 EDLAQILA 157 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 43/119 (36%), Positives = 63/119 (52%), Gaps = 3/119 (2%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N N G T LHLA E+ + L+++GA V D F PLH AA G L+++E+ Sbjct: 31 DVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEV 90 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALN 217 L G VN D G TPL A G+ + +L+ K+GA + D G A D++++ Sbjct: 91 LLKNGAD-VNAMDSDGMTPLHLAAKWGYLEIVEVLL-KHGA-VNAQDKFGKTAFDISID 146 Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 10/105 (9%) Query: 112 HLAVGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG 163 H+ +G+K E ++ L+ NGA V D PLH AA G L+++E+L G Sbjct: 3 HMDLGRKLLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHG 62 Query: 164 KSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 V+ D G+TPL A GH + +L+ K GA+ + +D+ G Sbjct: 63 AD-VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDG 105 >5AQA-A nrPDB Length = 418 Score = 71.6 bits (174), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/159 (34%), Positives = 81/159 (50%), Gaps = 7/159 (4%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 GR L + + Q E+ L++ +VN D++G TP H+A G+LE+V+ L Sbjct: 15 GRKLLEAARAGQDDEV-RILMANGADVN---AADNTGTTPLHLAAYSGHLEIVEVLLKHG 70 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D + + G T LHLA E+ + L++NGA V D PLH AA G ++ Sbjct: 71 ADVDASDVF--GYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEI 128 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLV 194 +E+L G V+ QDK G PL+ A +GH + A LV Sbjct: 129 VEVLLKAGAD-VDAQDKFGKRPLWLAADQGHAEIAAKLV 166 Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 44/120 (36%), Positives = 64/120 (53%), Gaps = 7/120 (5%) Query: 33 DQDGRIPLHWSVSFQAH-EITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 D G PLH + ++ H EI LL +V D D G+TP H+A G+LE+V+ L Sbjct: 44 DNTGTTPLHLA-AYSGHLEIVEVLLKHGADV---DASDVFGYTPLHLAAYWGHLEIVEVL 99 Query: 92 YDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVG 151 D+N + + G+T LHLA + E+ + L++ GA V +DKF + PL AA G Sbjct: 100 LKN--GADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQG 157 Score = 61.6 bits (148), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 42/112 (37%), Positives = 58/112 (51%), Gaps = 2/112 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N N G T LHLA E+ + L+++GA V D F PLH AA G L+++E+ Sbjct: 39 DVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEV 98 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210 L G VN D G TPL A G+ + +L+ K GA+ D D G + Sbjct: 99 LLKNGAD-VNAMDSDGMTPLHLAAKWGYKEIVEVLL-KAGADVDAQDKFGKR 148 Score = 45.1 bits (105), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 34/102 (33%), Positives = 52/102 (50%), Gaps = 10/102 (9%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +G+K E ++ L+ NGA V D PLH AA G L+++E+L G Sbjct: 14 LGRKLLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGAD- 72 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 V+ D G+TPL A GH + +L+ K GA+ + +D+ G Sbjct: 73 VDASDVFGYTPLHLAAYWGHLEIVEVLL-KNGADVNAMDSDG 113 >5JHQ-A nrPDB Length = 482 Score = 70.5 bits (171), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 65/243 (26%), Positives = 98/243 (40%), Gaps = 57/243 (23%) Query: 32 KDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 +D G IPLH + SF E+ S LL + + N D + +TP H A G ++V L Sbjct: 78 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD---NWNYTPLHEAAIKGKIDVCIVL 134 Query: 92 YDRPLKPDLNK------------------------------------------ITNQGVT 109 P++ +T V Sbjct: 135 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 194 Query: 110 C----------LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 C LHLA G + Q L+++GA V KDK +PLH A S G ++ ELL Sbjct: 195 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 254 Query: 160 CGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQ 219 G + VN D +TPL A ++ + LL+ +GA+ LV+ G A D+A + Sbjct: 255 LKHG-ACVNAMDLWQFTPLHEAASKNRVEVCSLLLS-HGADPTLVNCHGKSAVDMAPTPE 312 Query: 220 VKK 222 +++ Sbjct: 313 LRE 315 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 42/137 (30%), Positives = 70/137 (51%), Gaps = 3/137 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 AC G++ VK L D + + + + LH A G +V + L++ GA+V +D Sbjct: 22 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 80 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 IPLH A S G +++ LL G N +D +TPL A +G D ++L++ +G Sbjct: 81 GGLIPLHNACSFGHAEVVSLLLCQGADP-NARDNWNYTPLHEAAIKGKIDVCIVLLQ-HG 138 Query: 199 AEYDLVDNKGAKAEDVA 215 A+ ++ + G A D+A Sbjct: 139 ADPNIRNTDGKSALDLA 155 Score = 57.4 bits (137), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 104/277 (37%), Gaps = 66/277 (23%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N VQ LL + KD+ G +PLH + S+ +E+T LL VN Sbjct: 205 PLHLAAGYNRVRIVQLLLQHGADVH-AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 263 Query: 65 DDYPDDSGW--TPFHIACSVGNLEVV-----------------KSLYDRPLKPDLN---- 101 D W TP H A S +EV KS D P+L Sbjct: 264 MDL-----WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLT 318 Query: 102 -------------------------------KITNQGVTCLHLAVGK---KWFEVSQFLI 127 K T LH AV K +V++ L+ Sbjct: 319 YEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLL 378 Query: 128 ENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHG 187 GA+V K+K PLH AA ++E+L G + +N D G T L A GH Sbjct: 379 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG-AKMNALDTLGQTALHRAALAGHL 437 Query: 188 DAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 LL+ YG++ ++ +G A + NE V++ Sbjct: 438 QTCRLLLS-YGSDPSIISLQGFTAAQMG-NEAVQQIL 472 Score = 54.3 bits (129), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/160 (30%), Positives = 72/160 (45%), Gaps = 15/160 (9%) Query: 8 QACMENEFFKVQELLHSKPSLLLQKDQDGR--IPLHWSVSFQAHEITSFLLSKMENVNLD 65 +AC + +V+ L+ + + + KD GR PLH++ F ++ LL NV+ Sbjct: 21 EACRNGDVSRVKRLVDA--ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 78 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D D G P H ACS G+ EVV L + P N N T LH A K +V Sbjct: 79 D---DGGLIPLHNACSFGHAEVVSLLLCQGADP--NARDNWNYTPLHEAAIKGKIDVCIV 133 Query: 126 LIENGASVRIKDKFNQI------PLHRAASVGSLKLIELL 159 L+++GA I++ + P +A G K ELL Sbjct: 134 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL 173 Score = 29.6 bits (65), Expect = 1.0, Method: Compositional matrix adjust. Identities = 29/121 (23%), Positives = 49/121 (40%), Gaps = 10/121 (8%) Query: 17 KVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPF 76 +V ELL K + + +K++D PLH + +++ L +N D G T Sbjct: 372 QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN---ALDTLGQTAL 428 Query: 77 HIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIK 136 H A G+L+ + L P + I+ QG T + E Q ++ +R Sbjct: 429 HRAALAGHLQTCRLLLSYGSDPSI--ISLQGFTAAQMG-----NEAVQQILSESTPIRTS 481 Query: 137 D 137 D Sbjct: 482 D 482 >5AQB-A nrPDB Length = 428 Score = 70.1 bits (170), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 49/125 (39%), Positives = 68/125 (54%), Gaps = 4/125 (3%) Query: 69 DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIE 128 D+ GWTP H+A + G+LE+V+ L D+N G T LHLA E+ + L++ Sbjct: 44 DEVGWTPLHLA-AWGHLEIVECLLKN--GADVNAADIDGYTPLHLAAFSGHLEIVEVLLK 100 Query: 129 NGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGD 188 GA V D+ PLH AA G L+++E+L G VN QDK G TP A+ G+ D Sbjct: 101 YGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGAD-VNAQDKFGKTPRDLAIDNGNED 159 Query: 189 AAVLL 193 A +L Sbjct: 160 IAEVL 164 Score = 57.8 bits (138), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 44/121 (36%), Positives = 64/121 (52%), Gaps = 7/121 (5%) Query: 99 DLNKITNQGVTCLHLAVGKKW--FEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLI 156 D+N + G T LHLA W E+ + L++NGA V D PLH AA G L+++ Sbjct: 39 DVNALDEVGWTPLHLAA---WGHLEIVECLLKNGADVNAADIDGYTPLHLAAFSGHLEIV 95 Query: 157 ELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL 216 E+L G VN D+ G+TPL A GH + +L+ K GA+ + D G D+A+ Sbjct: 96 EVLLKYGAD-VNADDQAGFTPLHLAAIFGHLEIVEVLL-KNGADVNAQDKFGKTPRDLAI 153 Query: 217 N 217 + Sbjct: 154 D 154 Score = 53.5 bits (127), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 74/152 (48%), Gaps = 13/152 (8%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAH-EITSFLLSKMENVN 63 PLH A + ++ E L + + D DG PLH + +F H EI LL +VN Sbjct: 50 PLHLAAWGH--LEIVECLLKNGADVNAADIDGYTPLHLA-AFSGHLEIVEVLLKYGADVN 106 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 DD +G+TP H+A G+LE+V+ L D+N G T LA+ +++ Sbjct: 107 ADDQ---AGFTPLHLAAIFGHLEIVEVLLKN--GADVNAQDKFGKTPRDLAIDNGNEDIA 161 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 + L + V++KD +Q+ A VG ++L Sbjct: 162 EVLGKAATLVKVKDAADQL----GARVGYIEL 189 Score = 44.7 bits (104), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/102 (36%), Positives = 51/102 (50%), Gaps = 11/102 (10%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +GKK E ++ L+ NGA V D+ PLH AA G L+++E L G Sbjct: 14 LGKKLLEAARAGQDDECRILMANGADVNALDEVGWTPLHLAA-WGHLEIVECLLKNGAD- 71 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 VN D G+TPL A GH + +L+ KYGA+ + D G Sbjct: 72 VNAADIDGYTPLHLAAFSGHLEIVEVLL-KYGADVNADDQAG 112 >5GP7-A nrPDB Length = 169 Score = 67.8 bits (164), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 41/118 (34%), Positives = 64/118 (54%), Gaps = 2/118 (1%) Query: 109 TCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVN 168 T LHLA G EV+++L+E+GA V +DK IPLH AAS G + + LL + VN Sbjct: 45 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY-NTCVN 103 Query: 169 WQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLN 226 DK +TPL A +G LL+ +GA+ + + +G D+A + ++ ++ Sbjct: 104 ATDKWAFTPLHEAAQKGRTQLCALLL-AHGADPTMKNQEGQTPLDLATADDIRALLID 160 Score = 54.7 bits (130), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/140 (31%), Positives = 63/140 (45%), Gaps = 7/140 (5%) Query: 56 LSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAV 115 L EN+N D TP H+A NLEV + L + D+N G+ LH A Sbjct: 28 LCTPENINCRDT-QGRNSTPLHLAAGYNNLEVAEYLLEH--GADVNAQDKGGLIPLHNAA 84 Query: 116 GKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGW 175 +++ LI+ V DK+ PLH AA G +L LL G ++++G Sbjct: 85 SYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT-MKNQEGQ 143 Query: 176 TPLFHALAEGHGDAAVLLVE 195 TPL A A+ D LL++ Sbjct: 144 TPLDLATAD---DIRALLID 160 Score = 47.0 bits (110), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 59/137 (43%), Gaps = 9/137 (6%) Query: 15 FFKVQELLHSKPSLLLQKDQDGR--IPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSG 72 +VQ+L P + +D GR PLH + + E+ +LL +VN D G Sbjct: 22 LARVQKL--CTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ---DKGG 76 Query: 73 WTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGAS 132 P H A S G++++ L +N T LH A K ++ L+ +GA Sbjct: 77 LIPLHNAASYGHVDIAALLIK--YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 134 Query: 133 VRIKDKFNQIPLHRAAS 149 +K++ Q PL A + Sbjct: 135 PTMKNQEGQTPLDLATA 151 >6MWQ-A nrPDB Length = 493 Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 42/119 (35%), Positives = 68/119 (57%), Gaps = 2/119 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N + G+T LHLA + E+ + L++ GA V D + Q PLH AA+ G L+++E+ Sbjct: 30 DVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADLWGQTPLHLAATAGHLEIVEV 89 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALN 217 L G + VN D G TPL +GH + +L+ K+GA+ + D G A D++++ Sbjct: 90 LLKYG-ADVNALDLIGKTPLHLTAIDGHLEIVEVLL-KHGADVNAQDKFGKTAFDISID 146 Score = 57.0 bits (136), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 5/127 (3%) Query: 33 DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLY 92 D+ G PLH + EI LL +VN D G TP H+A + G+LE+V+ L Sbjct: 35 DRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADL---WGQTPLHLAATAGHLEIVEVLL 91 Query: 93 DRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGS 152 D+N + G T LHL E+ + L+++GA V +DKF + + G+ Sbjct: 92 K--YGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGN 149 Query: 153 LKLIELL 159 L E+L Sbjct: 150 EDLAEIL 156 Score = 53.5 bits (127), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 10/99 (10%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +GKK E ++ L+ NGA V D+F PLH AA G L+++E+L G + Sbjct: 5 LGKKLLEAARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCG-AD 63 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVD 205 VN D G TPL A GH + +L+ KYGA+ + +D Sbjct: 64 VNAADLWGQTPLHLAATAGHLEIVEVLL-KYGADVNALD 101 >5HKP-A nrPDB Length = 351 Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 48/144 (33%), Positives = 74/144 (51%), Gaps = 3/144 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A GN E + +L PL + + + T LHLA G + Q L+++GA V KDK Sbjct: 31 AARSGNEEKLMALLT-PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDK 89 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 +PLH A S G ++ ELL G + VN D +TPL A ++ + LL+ +G Sbjct: 90 GGLVPLHNACSYGHYEVTELLLKHG-ACVNAMDLWQFTPLHEAASKNRVEVCSLLLS-HG 147 Query: 199 AEYDLVDNKGAKAEDVALNEQVKK 222 A+ LV+ G A D+A ++++ Sbjct: 148 ADPTLVNCHGKSAVDMAPTPELRE 171 Score = 57.0 bits (136), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 104/277 (37%), Gaps = 66/277 (23%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N VQ LL + KD+ G +PLH + S+ +E+T LL VN Sbjct: 61 PLHLAAGYNRVRIVQLLLQHGADVH-AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 119 Query: 65 DDYPDDSGW--TPFHIACSVGNLEVV-----------------KSLYDRPLKPDLN---- 101 D W TP H A S +EV KS D P+L Sbjct: 120 MDL-----WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLT 174 Query: 102 -------------------------------KITNQGVTCLHLAVGK---KWFEVSQFLI 127 K T LH AV K +V++ L+ Sbjct: 175 YEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLL 234 Query: 128 ENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHG 187 GA+V K+K PLH AA ++E+L G + +N D G T L A GH Sbjct: 235 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG-AKMNALDSLGQTALHRAALAGHL 293 Query: 188 DAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 LL+ YG++ ++ +G A + NE V++ Sbjct: 294 QTCRLLLS-YGSDPSIISLQGFTAAQMG-NEAVQQIL 328 >5MIO-C nrPDB Length = 573 Score = 61.2 bits (147), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 42/119 (35%), Positives = 62/119 (52%), Gaps = 2/119 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N G+T LHLA E+ + L+++GA V D PLH AA +G L+++E+ Sbjct: 435 DVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASDLMGSTPLHLAALIGHLEIVEV 494 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALN 217 L G + VN D G TPL A GH L+ K+GA+ + D G A D +++ Sbjct: 495 LLKHG-ADVNAVDTWGDTPLRLAAVMGHLKIVEALL-KHGADVNAQDKFGKTAYDTSID 551 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 40/127 (31%), Positives = 62/127 (48%), Gaps = 5/127 (3%) Query: 33 DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLY 92 D G PLH + ++ EI LL +V+ D G TP H+A +G+LE+V+ L Sbjct: 440 DASGLTPLHLAATYGHLEIVEVLLKHGADVSASDL---MGSTPLHLAALIGHLEIVEVLL 496 Query: 93 DRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGS 152 D+N + G T L LA ++ + L+++GA V +DKF + + GS Sbjct: 497 KHG--ADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHGADVNAQDKFGKTAYDTSIDNGS 554 Query: 153 LKLIELL 159 L E+L Sbjct: 555 EDLAEIL 561 Score = 48.1 bits (113), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 53/102 (51%), Gaps = 10/102 (9%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +GKK E ++ L+ NGA V D PLH AA+ G L+++E+L G + Sbjct: 410 LGKKLLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHG-AD 468 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 V+ D G TPL A GH + +L+ K+GA+ + VD G Sbjct: 469 VSASDLMGSTPLHLAALIGHLEIVEVLL-KHGADVNAVDTWG 509 >5ET1-A nrPDB Length = 353 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/139 (32%), Positives = 68/139 (48%), Gaps = 2/139 (1%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLI-EN 129 +G TP H A + G L ++ L + + + N G T LHLA +V ++L+ + Sbjct: 70 NGATPAHDAAATGYLSCLQWLLTQG-GCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQG 128 Query: 130 GASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDA 189 GA+ I +P+H AA+ G L ++LL G VN Q G TPL+ A EGH + Sbjct: 129 GANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEV 188 Query: 190 AVLLVEKYGAEYDLVDNKG 208 LV++ A+ L G Sbjct: 189 TKYLVQECSADPHLRAQDG 207 Score = 44.3 bits (103), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 65/156 (41%), Gaps = 5/156 (3%) Query: 75 PFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLI-ENGASV 133 P H A G L ++ L + P +++ N G T H A + Q+L+ + G V Sbjct: 40 PVHHAARSGKLHCLRYLVEEVALPAVSRARN-GATPAHDAAATGYLSCLQWLLTQGGCRV 98 Query: 134 RIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 + KD LH AA G +++ L G + G P+ +A A+G + LL Sbjct: 99 QEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLL 158 Query: 194 VEKYGAEYDLVDNKGAKAEDVALNE---QVKKFFLN 226 V Y + N GA +A E +V K+ + Sbjct: 159 VGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQ 194 Score = 43.9 bits (102), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 79/220 (35%), Gaps = 36/220 (16%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 P H A +Q LL + +KD G LH + F ++ +LL + Sbjct: 74 PAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLL--YQGGAN 131 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D+G P H A + G+L +K L +N TN G T L+LA + EV++ Sbjct: 132 SAITTDTGALPIHYAAAKGDLPSLKLLVGH-YPEGVNAQTNNGATPLYLACQEGHLEVTK 190 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 +L++ + + P RA + G TPL A Sbjct: 191 YLVQ---------ECSADPHLRA------------------------QDGMTPLHAAAQM 217 Query: 185 GHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 GH V LV + D+ GA A A + K Sbjct: 218 GHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVL 257 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/139 (30%), Positives = 62/139 (44%), Gaps = 17/139 (12%) Query: 5 PLHQACMENEF----FKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 PL+ AC E + VQE + P L + QDG PLH + + + +L+S Sbjct: 176 PLYLACQEGHLEVTKYLVQEC-SADPHL---RAQDGMTPLHAAAQMGHNPVLVWLVS-FA 230 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVK--SLYDRPLKPDLNKITNQGVTCLHLAVGKK 118 +V+ + D G T H A S G+ +V+ L+ + DL G T LH A Sbjct: 231 DVSFSEQ-DHDGATAMHFAASRGHTKVLSWLLLHGAEISQDL-----WGGTPLHDAAENG 284 Query: 119 WFEVSQFLIENGASVRIKD 137 E Q L NGA + ++D Sbjct: 285 ELECCQILAVNGAGLDVRD 303 >6FES-A nrPDB Length = 367 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 42/117 (35%), Positives = 59/117 (50%), Gaps = 2/117 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N G T LHLA + + + L++NGA V D+ PLH AA G L+++E+ Sbjct: 31 DVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEV 90 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 L G + VN D G PL A GH + +L+ K GA+ D G ED+A Sbjct: 91 LLKNG-AGVNATDVIGTAPLHLAAMWGHEEIVEVLL-KNGADARAQDKFGKTPEDLA 145 Score = 54.7 bits (130), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 7/112 (6%) Query: 33 DQDGRIPLHWSVSFQAH-EITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 D+ G PLH + +++ H I LL +VN +D + G TP H+A G+LE+V+ L Sbjct: 36 DETGFTPLHLA-AWEGHLGIVEVLLKNGADVNAND---ERGHTPLHLAAYTGHLEIVEVL 91 Query: 92 YDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIP 143 +N G LHLA E+ + L++NGA R +DKF + P Sbjct: 92 LKNG--AGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGADARAQDKFGKTP 141 Score = 45.4 bits (106), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 10/103 (9%) Query: 115 VGKKWFEVSQ--------FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +GKK E ++ L+ NGA V D+ PLH AA G L ++E+L G + Sbjct: 6 LGKKLLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNG-AD 64 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGA 209 VN D++G TPL A GH + +L+ K GA + D G Sbjct: 65 VNANDERGHTPLHLAAYTGHLEIVEVLL-KNGAGVNATDVIGT 106 >4Z68-A nrPDB Length = 155 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 43/122 (35%), Positives = 63/122 (51%), Gaps = 3/122 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G++E VK L + I + T LH A G V ++L+++GA V KDK Sbjct: 10 AAKAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 68 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 +PLH A S G ++ ELL G + VN D +TPL A A+G + LL++ +G Sbjct: 69 GGLVPLHNACSYGHYEVAELLVKHG-AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ-HG 126 Query: 199 AE 200 A+ Sbjct: 127 AD 128 Score = 47.8 bits (112), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 7/115 (6%) Query: 32 KDQDGR--IPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVK 89 +D +GR PLH++ + + +LL +V+ D G P H ACS G+ EV + Sbjct: 31 RDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA---KDKGGLVPLHNACSYGHYEVAE 87 Query: 90 SLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPL 144 L ++ + T LH A K +E+ + L+++GA K++ PL Sbjct: 88 LLVKHGAVVNVADLWK--FTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 140 Score = 40.0 bits (92), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 30/96 (31%), Positives = 42/96 (43%), Gaps = 8/96 (8%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N V+ LL + KD+ G +PLH + S+ +E+ L+ VN+ Sbjct: 40 PLHFAAGYNRVSVVEYLLQHGADVH-AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 98 Query: 65 DDYPDDSGW--TPFHIACSVGNLEVVKSLYDRPLKP 98 D W TP H A + G E+ K L P Sbjct: 99 ADL-----WKFTPLHEAAAKGKYEICKLLLQHGADP 129 >3B7B-A nrPDB Length = 237 Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 40/134 (29%), Positives = 64/134 (47%), Gaps = 3/134 (2%) Query: 74 TPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASV 133 +P H A G++++ L +++ + T L A E ++LI+ GA V Sbjct: 13 SPLHAAAEAGHVDICHMLVQA--GANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALV 70 Query: 134 RIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 KD LH AA G ++++ L G+ VN QD GWTP+ A H D LL Sbjct: 71 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 130 Query: 194 VEKYGAEYDLVDNK 207 + K G++ ++ DN+ Sbjct: 131 LSK-GSDINIRDNE 143 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 6/192 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A E + +L + + +D R PL + E +L+ L Sbjct: 14 PLHAA-AEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGA---L 69 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D D G T H+A G+ EVV+ L + D+N + G T + A K ++ + Sbjct: 70 VDPKDAEGSTCLHLAAKKGHYEVVQYLLSNG-QMDVNCQDDGGWTPMIWATEYKHVDLVK 128 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 L+ G+ + I+D I LH AA G + + E+L K ++ + G +PL A E Sbjct: 129 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA-AKCDLHAVNIHGDSPLHIAARE 187 Query: 185 GHGDAAVLLVEK 196 D VL + + Sbjct: 188 NRYDCVVLFLSR 199 Score = 46.2 bits (108), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 67/143 (46%), Gaps = 5/143 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 LH A + + VQ LL + + +D G P+ W+ ++ ++ LLSK ++N+ Sbjct: 81 LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR 140 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D ++ H A G +++ + L K DL+ + G + LH+A + ++ Sbjct: 141 DNEEN---ICLHWAAFSGCVDIAEILL--AAKCDLHAVNIHGDSPLHIAARENRYDCVVL 195 Query: 126 LIENGASVRIKDKFNQIPLHRAA 148 + + V +K+K + PL A+ Sbjct: 196 FLSRDSDVTLKNKEGETPLQCAS 218 >6BY9-A nrPDB Length = 328 Score = 58.2 bits (139), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 40/134 (29%), Positives = 64/134 (47%), Gaps = 3/134 (2%) Query: 74 TPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASV 133 +P H A G++++ L +++ + T L A E ++LI+ GA V Sbjct: 104 SPLHAAAEAGHVDICHMLVQA--GANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALV 161 Query: 134 RIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 KD LH AA G ++++ L G+ VN QD GWTP+ A H D LL Sbjct: 162 DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLL 221 Query: 194 VEKYGAEYDLVDNK 207 + K G++ ++ DN+ Sbjct: 222 LSK-GSDINIRDNE 234 Score = 47.8 bits (112), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 6/192 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A E + +L + + +D R PL + E +L+ V Sbjct: 105 PLH-AAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALV-- 161 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D D G T H+A G+ EVV+ L + D+N + G T + A K ++ + Sbjct: 162 -DPKDAEGSTCLHLAAKKGHYEVVQYLLSNG-QMDVNCQDDGGWTPMIWATEYKHVDLVK 219 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 L+ G+ + I+D I LH AA G + + E+L K ++ + G +PL A E Sbjct: 220 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA-AKCDLHAVNIHGDSPLHIAARE 278 Query: 185 GHGDAAVLLVEK 196 D VL + + Sbjct: 279 NRYDCVVLFLSR 290 Score = 45.4 bits (106), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/143 (23%), Positives = 67/143 (46%), Gaps = 5/143 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 LH A + + VQ LL + + +D G P+ W+ ++ ++ LLSK ++N+ Sbjct: 172 LHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIR 231 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D ++ H A G +++ + L K DL+ + G + LH+A + ++ Sbjct: 232 DNEEN---ICLHWAAFSGCVDIAEILL--AAKCDLHAVNIHGDSPLHIAARENRYDCVVL 286 Query: 126 LIENGASVRIKDKFNQIPLHRAA 148 + + V +K+K + PL A+ Sbjct: 287 FLSRDSDVTLKNKEGETPLQCAS 309 >5CBO-A nrPDB Length = 176 Score = 57.8 bits (138), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 38/97 (39%), Positives = 53/97 (54%), Gaps = 1/97 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 D+N + N GVT LHLA FE+ + L++ GA V D PLH AA G L ++E+ Sbjct: 28 DVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDATGDTPLHLAAKWGYLGIVEV 87 Query: 159 LCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVE 195 L G + VN QDK G T ++ G+ D A +L + Sbjct: 88 LLKYG-ADVNAQDKFGKTAFDISIDNGNEDLAEILCK 123 Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/125 (35%), Positives = 61/125 (48%), Gaps = 15/125 (12%) Query: 115 VGKKWFEVS--------QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 +GKK E + + L+ NGA V D F PLH AA G +++E+L G + Sbjct: 3 LGKKLLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYG-AD 61 Query: 167 VNWQDKQGWTPLFHALAEGH-GDAAVLLVEKYGAEYDLVDNKGAKAEDVAL---NEQVKK 222 VN D G TPL A G+ G VLL KYGA+ + D G A D+++ NE + + Sbjct: 62 VNASDATGDTPLHLAAKWGYLGIVEVLL--KYGADVNAQDKFGKTAFDISIDNGNEDLAE 119 Query: 223 FFLNN 227 N Sbjct: 120 ILCKN 124 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 2/92 (2%) Query: 69 DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIE 128 D+ G TP H+A G+ E+V+ L D+N G T LHLA + + + L++ Sbjct: 33 DNFGVTPLHLAAYWGHFEIVEVLL--KYGADVNASDATGDTPLHLAAKWGYLGIVEVLLK 90 Query: 129 NGASVRIKDKFNQIPLHRAASVGSLKLIELLC 160 GA V +DKF + + G+ L E+LC Sbjct: 91 YGADVNAQDKFGKTAFDISIDNGNEDLAEILC 122 Score = 35.4 bits (80), Expect = 0.022, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 5/99 (5%) Query: 33 DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLY 92 D G PLH + + EI LL +VN D +G TP H+A G L +V+ L Sbjct: 33 DNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDA---TGDTPLHLAAKWGYLGIVEVLL 89 Query: 93 DRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGA 131 D+N G T +++ ++++ L +N A Sbjct: 90 --KYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKA 126 Score = 27.7 bits (60), Expect = 3.8, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 40/94 (42%), Gaps = 7/94 (7%) Query: 1 MSNY---PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLS 57 M N+ PLH A F ++ E+L + + D G PLH + + I LL Sbjct: 32 MDNFGVTPLHLAAYWGHF-EIVEVLLKYGADVNASDATGDTPLHLAAKWGYLGIVEVLLK 90 Query: 58 KMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 +VN D G T F I+ GN ++ + L Sbjct: 91 YGADVNA---QDKFGKTAFDISIDNGNEDLAEIL 121 >4O1O-A nrPDB Length = 717 Score = 57.4 bits (137), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 83/206 (40%), Gaps = 29/206 (14%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L QA E + +V++LL Q+++ G PLH +V + ++ + LL + L Sbjct: 12 LTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLR 71 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 +G TPF IA GN+ +++ L P D+N+ G T A E +F Sbjct: 72 KR---NGATPFIIAGITGNVRLLQLLL--PNVEDVNECDVNGFTAFMEAAVYGRVEALRF 126 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEG 185 L ENGA V +HR ++ K G T L A +G Sbjct: 127 LYENGADVN---------MHRKTKQDQERI---------------RKGGATALMDAAEKG 162 Query: 186 HGDAAVLLVEKYGAEYDLVDNKGAKA 211 H +L+ AE D DN G A Sbjct: 163 HVGVVTILLHAMKAEVDARDNMGRNA 188 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 8/121 (6%) Query: 21 LLHSKPSLLLQKDQDGRIPLHWSV----SFQAHEITSFLLSKMENVNLDDYPDDSGWTPF 76 LLH+ + + +D GR L +++ +A IT LL +VN+ + TP Sbjct: 170 LLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNV---RGEGSKTPL 226 Query: 77 HIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIK 136 +A NL++V+ L ++ + ++N +G T L LAV + E+++ L GAS Sbjct: 227 ILAVERKNLDLVQMLLEQE-QIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCG 285 Query: 137 D 137 D Sbjct: 286 D 286 >3EU9-A nrPDB Length = 240 Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 98/228 (42%), Gaps = 11/228 (4%) Query: 2 SNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61 S + + +A + + +EL+ + + Q D++ LHW+ ++ + +SK Sbjct: 9 STWDIVKATQYGIYERCRELVEAGYDVR-QPDKENVTLLHWAAINNRIDLVKYYISKGAI 67 Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 V D D TP H A G+L +V L P L I +G +C+HLA Sbjct: 68 V--DQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSL--IDGEGCSCIHLAAQFGHTS 123 Query: 122 VSQFLIENGASVRIKDKFNQIPLHRAA-SVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 + +LI G V + D+ PL AA S+ LL S VN DK H Sbjct: 124 IVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVS-VNLGDKYHKNTALH 182 Query: 181 -ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNN 227 A+ G+ LL+E GA D + KG A D+A +Q K ++ N Sbjct: 183 WAVLAGNTTVISLLLEA-GANVDAQNIKGESALDLA--KQRKNVWMIN 227 >6AUN-A nrPDB Length = 752 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/179 (25%), Positives = 82/179 (45%), Gaps = 13/179 (7%) Query: 5 PLHQACM--ENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 PLH AC + E +V L +++ +++ P+H ++ F ++S M++ Sbjct: 223 PLHLACQMGKQEMVRVLLLCNARCNVM----GPSGFPIHTAMKFSQKGCAEMIIS-MDSS 277 Query: 63 NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEV 122 + G +P H A N E+ + L R D++ + G T LH+AV + F+ Sbjct: 278 QIHSKDPRYGASPLHWA---KNAEMARMLLKRGC--DVDSTSAAGNTALHVAVMRNRFDC 332 Query: 123 SQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHA 181 L+ GA+ + PLH A S ++++I+ L G + V+ + G TP F A Sbjct: 333 VMVLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFG-AEVDTPNDFGETPAFMA 390 Score = 42.0 bits (97), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 70/159 (44%), Gaps = 5/159 (3%) Query: 69 DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIE 128 ++ G TP H+AC G+ E++ L ++ N+G T H AV +V Q L + Sbjct: 149 NEEGCTPLHLACRKGDSEILVELVQY-CHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGK 207 Query: 129 NG-ASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHG 187 N A + +K PLH A +G +++ +L L + N G+ P+ A+ Sbjct: 208 NASAGLNQVNKQGLTPLHLACQMGKQEMVRVLL-LCNARCNVMGPSGF-PIHTAMKFSQK 265 Query: 188 DAAVLLVEKYGAEYDLVDNK-GAKAEDVALNEQVKKFFL 225 A +++ ++ D + GA A N ++ + L Sbjct: 266 GCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLL 304 Score = 41.2 bits (95), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 53/236 (22%), Positives = 95/236 (40%), Gaps = 39/236 (16%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH AC + + + EL+ + + D G H++V ++ LL K + L Sbjct: 155 PLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQ-LLGKNASAGL 213 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLY----------------------------DRPL 96 + + G TP H+AC +G E+V+ L + + Sbjct: 214 NQV-NKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFSQKGCAEMII 272 Query: 97 KPDLNKITNQ----GVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGS 152 D ++I ++ G + LH A K E+++ L++ G V LH A Sbjct: 273 SMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCDVDSTSAAGNTALHVAVMRNR 329 Query: 153 LKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 + +L G +A + G TPL A+++ + + L+ +GAE D ++ G Sbjct: 330 FDCVMVLLTYGANA-GTPGEHGNTPLHLAISKDNMEMIKALI-VFGAEVDTPNDFG 383 Score = 36.6 bits (83), Expect = 0.010, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 3/123 (2%) Query: 73 WTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG-A 131 WT H+A +G E + R + + +G T LHLA K E+ L++ A Sbjct: 120 WTVTHLAVELGIRECFH--HSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHA 177 Query: 132 SVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAV 191 + + D + H A + ++++LL + +N +KQG TPL A G + Sbjct: 178 QMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMVR 237 Query: 192 LLV 194 +L+ Sbjct: 238 VLL 240 Score = 32.7 bits (73), Expect = 0.13, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 3/65 (4%) Query: 166 AVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL---NEQVKK 222 A + ++++G TPL A +G + V LV+ A+ D+ DNKG A A+ N QV + Sbjct: 144 ANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQ 203 Query: 223 FFLNN 227 N Sbjct: 204 LLGKN 208 >4OAU-C nrPDB Length = 699 Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 98/219 (44%), Gaps = 18/219 (8%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 N+ L +A + VQ+LL ++ Q+++ G PLH +V +I LL + Sbjct: 6 NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP 65 Query: 63 NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEV 122 L +G TPF +A G+++++K + D+N+ G T A + Sbjct: 66 VL---RKKNGATPFILAAIAGSVKLLKLFLSKG--ADVNECDFYGFTAFMEAAVYGKVKA 120 Query: 123 SQFLIENGASV--RIKDKFNQIPLHR--------AASVGSLKLIELLCGLGKSAVNWQDK 172 +FL + GA+V R K K +Q L + AA G ++++++L + VN D Sbjct: 121 LKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDN 180 Query: 173 QGWTPLFHALAEGHG---DAAVLLVEKYGAEYDLVDNKG 208 G L HAL +A L+ +GA+ ++ +G Sbjct: 181 MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 219 Score = 50.8 bits (120), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 15/167 (8%) Query: 55 LLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLA 114 LL NVN + ++ GWTP H A + ++V+ L P L K G T LA Sbjct: 24 LLEGGANVNFQE--EEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK--KNGATPFILA 79 Query: 115 VGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ- 173 ++ + + GA V D + AA G +K ++ L G + VN + K Sbjct: 80 AIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG-ANVNLRRKTK 138 Query: 174 ---------GWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKA 211 G T L A +GH + +L+++ GA+ + DN G A Sbjct: 139 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNA 185 Score = 32.3 bits (72), Expect = 0.16, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 4/87 (4%) Query: 51 ITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTC 110 IT LL +VN+ + G TP +A +L +V+ L ++ ++N + G T Sbjct: 201 ITHLLLDHGADVNV---RGERGKTPLILAVEKKHLGLVQRLLEQE-HIEINDTDSDGKTA 256 Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKD 137 L LAV K ++++ L + GAS D Sbjct: 257 LLLAVELKLKKIAELLCKRGASTDCGD 283 >1G3N-B nrPDB Length = 168 Score = 50.4 bits (119), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 50/105 (47%), Gaps = 3/105 (2%) Query: 72 GWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGA 131 G T + +GN E+ + L R PDL T G +H A + + Q L+E A Sbjct: 38 GRTALQV-MKLGNPEIARRLLLRGANPDLKDRT--GFAVIHDAARAGFLDTLQTLLEFQA 94 Query: 132 SVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWT 176 V I+D +PLH AA G L+++E L S V ++ +G T Sbjct: 95 DVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDT 139 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 1/95 (1%) Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 E+++ L+ GA+ +KD+ +H AA G L ++ L ++ VN +D +G PL Sbjct: 51 EIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEF-QADVNIEDNEGNLPLHL 109 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 A EGH LV+ + ++KG A D+A Sbjct: 110 AAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLA 144 >4OT9-A nrPDB Length = 359 Score = 47.8 bits (112), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 3/119 (2%) Query: 26 PSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNL 85 P LL D +G P+H +V ++ E L+ V + G T H+A + L Sbjct: 184 PQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATER--QGGRTALHLATEMEEL 241 Query: 86 EVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPL 144 +V L + L+ ++N T G T LHLA G + +++ L++ GA + +++ PL Sbjct: 242 GLVTHLVTK-LRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 299 Score = 46.2 bits (108), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/170 (28%), Positives = 78/170 (45%), Gaps = 10/170 (5%) Query: 37 RIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIA--CSVGNLEVVKSLYDR 94 + PLH +V + SFLL + L D DS H+A G E++++L Sbjct: 122 QTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSA---MHLALRAGAGAPELLRALLQS 178 Query: 95 --PLKPDLNKITN-QGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK-FNQIPLHRAASV 150 P P L + + +G+ +HLAV + E L+++GA V ++ + LH A + Sbjct: 179 GAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEM 238 Query: 151 GSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAE 200 L L+ L ++ VN + G TPL A G+ LL+ K GA+ Sbjct: 239 EELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLL-KAGAD 287 Score = 41.6 bits (96), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/152 (29%), Positives = 69/152 (45%), Gaps = 11/152 (7%) Query: 69 DDSGWTPFHIACSVGNLEVVKSL-YDRPLKPDLN--KITNQ-GVTCLHLAVGKKWFEVSQ 124 D++G TP H+A G V++ + Y DL +TN T LHLAV V Sbjct: 79 DENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVS 138 Query: 125 FLIENGASVRIKDKFNQIPLHRA--ASVGSLKLIELLCGLGKSAV----NWQDKQGWTPL 178 FL+ GA + D+ +H A A G+ +L+ L G AV + D +G P+ Sbjct: 139 FLLRVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPV 198 Query: 179 FHALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210 A+ + LLV+ GAE + + +G + Sbjct: 199 HLAVRARSPECLDLLVDS-GAEVEATERQGGR 229 Score = 33.9 bits (76), Expect = 0.064, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 38/81 (46%), Gaps = 4/81 (4%) Query: 4 YPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME-NV 62 YP+H A + L+ S + + Q GR LH + + + + L++K+ NV Sbjct: 196 YPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANV 255 Query: 63 NLDDYPDDSGWTPFHIACSVG 83 N + +G TP H+A +G Sbjct: 256 NARTF---AGNTPLHLAAGLG 273 >6EMK-G nrPDB Length = 426 Score = 46.6 bits (109), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 77/176 (43%), Gaps = 5/176 (2%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKD-QDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 L +A +E V+ LL P LL D ++G LH++ S+ + L ++ + Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYA-SYHGRYLICVYLIQLGHDKH 67 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 + G T H+A G+ + + L + +N G +H+A +++ Sbjct: 68 ELIKTFKGNTCVHLALMKGHEQTLHLLLQQ-FPRFINHRGENGRAPIHIACMNDYYQCLS 126 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAV--NWQDKQGWTPL 178 LI GA + + D PLH GS+ +++L G+ ++ N +DK W P+ Sbjct: 127 LLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPI 182 Score = 40.8 bits (94), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 29/84 (34%), Positives = 45/84 (53%), Gaps = 5/84 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 P+H ACM N++++ LL + L D +G PLH + + + LL++ E V+L Sbjct: 112 PIHIACM-NDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGE-VSL 169 Query: 65 DDYPDDSG-WTPFHIACS--VGNL 85 DD D G W P +A + VGN+ Sbjct: 170 DDNVRDKGNWKPIDVAQTFEVGNI 193 Score = 32.3 bits (72), Expect = 0.15, Method: Compositional matrix adjust. Identities = 23/92 (25%), Positives = 42/92 (45%), Gaps = 5/92 (5%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 N +H A M+ + LL P + + ++GR P+H + ++ S L+ V Sbjct: 76 NTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIG----V 131 Query: 63 NLDDYP-DDSGWTPFHIACSVGNLEVVKSLYD 93 D + D +G TP H+ G++ +K L + Sbjct: 132 GADLWVMDTNGDTPLHVCLEYGSISCMKMLLN 163 >3LJN-A nrPDB Length = 364 Score = 44.7 bits (104), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 105/227 (46%), Gaps = 32/227 (14%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 +H A + + +V+ L+ + S +Q ++ G LH + F + +L S E +L Sbjct: 24 IHVAARKGQTDEVRRLIETGVSPTIQ-NRFGCTALHLACKFGCVDTAKYLASVGEVHSLW 82 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYD----RPLKPD----------LNKITN-----Q 106 G P H+A ++V +L + R P+ +N+I + + Sbjct: 83 -----HGQKPIHLAVMANKTDLVVALVEGAKERGQMPESLLNECDEREVNEIGSHVKHCK 137 Query: 107 GVTCLH--LAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGK 164 G T LH + +G ++ E+ + L++ GAS KDK ++ PL RA + + ++L+ Sbjct: 138 GQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKADETPLMRAMEFRNREALDLMMDTVP 197 Query: 165 SA----VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNK 207 S +++ +KQG + L A+ D A+ VE G + ++ DN+ Sbjct: 198 SKSSLRLDYANKQGNSHLHWAILINWEDVAMRFVE-MGIDVNMEDNE 243 Score = 40.4 bits (93), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 46/100 (46%), Gaps = 5/100 (5%) Query: 98 PDLNKIT--NQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 P LN+I ++ + +H+A K + + LIE G S I+++F LH A G + Sbjct: 9 PKLNRIKSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQNRFGCTALHLACKFGCVDT 68 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVE 195 + L +G+ W G P+ A+ D V LVE Sbjct: 69 AKYLASVGEVHSLW---HGQKPIHLAVMANKTDLVVALVE 105 Score = 37.4 bits (85), Expect = 0.005, Method: Compositional matrix adjust. Identities = 35/123 (28%), Positives = 53/123 (43%), Gaps = 11/123 (8%) Query: 36 GRIPLHWSVSFQAH--EITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYD 93 G+ LHW V E+ L+ + D D+ TP A N E + + D Sbjct: 138 GQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKADE---TPLMRAMEFRNREALDLMMD 194 Query: 94 R-PLKPDL--NKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH---RA 147 P K L + QG + LH A+ W +V+ +E G V ++D + +PL+ RA Sbjct: 195 TVPSKSSLRLDYANKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTVPLYLSVRA 254 Query: 148 ASV 150 A V Sbjct: 255 AMV 257 Score = 28.1 bits (61), Expect = 3.1, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 11/76 (14%) Query: 63 NLDDYP-------DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-GVTCLHLA 114 ++ D+P DD H+A G + V+ L + + P I N+ G T LHLA Sbjct: 4 SMTDFPKLNRIKSDDENMEKIHVAARKGQTDEVRRLIETGVSP---TIQNRFGCTALHLA 60 Query: 115 VGKKWFEVSQFLIENG 130 + +++L G Sbjct: 61 CKFGCVDTAKYLASVG 76 >5D68-A nrPDB Length = 486 Score = 43.9 bits (102), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 5/107 (4%) Query: 39 PLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKP 98 PLH S E+ S LLS+ +VN D W P H AC G +E + L ++ K Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVN---QLDSDHWAPIHYACWYGKVEATRILLEKG-KC 96 Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVR-IKDKFNQIPL 144 + N + Q + LH A G E+ Q L+ + + R I D+ + PL Sbjct: 97 NPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPL 143 Score = 40.8 bits (94), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 78/165 (47%), Gaps = 16/165 (9%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 + ++PLH++ E + + LL + S+ Q D D P+H++ + E T LL K + Sbjct: 37 VDDFPLHRSACEGDSELLSRLLSERFSVN-QLDSDHWAPIHYACWYGKVEATRILLEKGK 95 Query: 61 -NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKK- 118 N NL + S P H A G+ E+V+ L + P + D + QG + L++ K Sbjct: 96 CNPNLLNGQLSS---PLHFAAGGGHAEIVQILLNHP-ETDRHITDQQGRSPLNICEENKQ 151 Query: 119 --WFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCG 161 W E ++ L E I + ++ ++R GS + +EL G Sbjct: 152 NNWEEAAKLLKE-----AINKPYEKVRIYRMD--GSYRSVELKHG 189 Score = 30.8 bits (68), Expect = 0.45, Method: Compositional matrix adjust. Identities = 24/98 (24%), Positives = 41/98 (41%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 LH + + E+ L+ SV D + P+H A G ++ +L GK N Sbjct: 42 LHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLL 101 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKG 208 + Q +PL A GH + +L+ + + D +G Sbjct: 102 NGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQG 139 >1BD8-A nrPDB Length = 156 Score = 43.1 bits (100), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 50/106 (47%), Gaps = 4/106 (3%) Query: 83 GNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQI 142 G+ + L + P++ + G + +H A + + + L+E+GA V + D + Sbjct: 46 GSTAIALELLKQGASPNVQDTS--GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGAL 103 Query: 143 PLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGD 188 P+H A G ++ L +S ++ +D +G TPL AL G D Sbjct: 104 PIHLAVQEGHTAVVSFLA--AESDLHRRDARGLTPLELALQRGAQD 147 Score = 34.3 bits (77), Expect = 0.043, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 44/95 (46%), Gaps = 6/95 (6%) Query: 32 KDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSL 91 +D G P+H + + L+ +VN+ PD +G P H+A G+ VV L Sbjct: 64 QDTSGTSPVHDAARTGFLDTLKVLVEHGADVNV---PDGTGALPIHLAVQEGHTAVVSFL 120 Query: 92 YDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFL 126 + DL++ +G+T L LA+ + ++ L Sbjct: 121 A---AESDLHRRDARGLTPLELALQRGAQDLVDIL 152 >2KXP-C nrPDB Length = 118 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 49/104 (47%), Gaps = 3/104 (2%) Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 EV + + G V + + PLH AA G L+++E L L + +N DK TPL Sbjct: 17 EVKDY-VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLL-LKGADINAPDKHHITPLLS 74 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 A+ EGH LL+ K GA+ + G A + N+ +K Sbjct: 75 AVYEGHVSCVKLLLSK-GADKTVKGPDGLTALEATDNQAIKALL 117 Score = 35.0 bits (79), Expect = 0.029, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 2/88 (2%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 F A G+L+ VK + D+N+ G LH A E+ +FL+ GA + Sbjct: 6 FMWALKNGDLDEVKDYVAK--GEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINA 63 Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLG 163 DK + PL A G + ++LL G Sbjct: 64 PDKHHITPLLSAVYEGHVSCVKLLLSKG 91 Score = 34.3 bits (77), Expect = 0.045, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 39/87 (44%), Gaps = 12/87 (13%) Query: 34 QDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLY- 92 + GR PLH++ EI FLL K ++N PD TP A G++ VK L Sbjct: 33 EGGRKPLHYAADCGQLEILEFLLLKGADIN---APDKHHITPLLSAVYEGHVSCVKLLLS 89 Query: 93 ---DRPLK-PD----LNKITNQGVTCL 111 D+ +K PD L NQ + L Sbjct: 90 KGADKTVKGPDGLTALEATDNQAIKAL 116 >1BLX-B nrPDB Length = 166 Score = 42.0 bits (97), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 7/110 (6%) Query: 79 ACSVGNLEVVKSLYDRPL-KPD-LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIK 136 A + G+++ V+ L R L PD LN+ + + E L++ GAS ++ Sbjct: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALE----LLKQGASPNVQ 70 Query: 137 DKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGH 186 D P+H AA G L +++L G VN D G P+ A+ EGH Sbjct: 71 DASGTSPVHDAARTGFLDTLKVLVEHGAD-VNALDSTGSLPIHLAIREGH 119 Score = 36.2 bits (82), Expect = 0.012, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 35/72 (48%), Gaps = 2/72 (2%) Query: 107 GVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 G + +H A + + + L+E+GA V D +P+H A G ++ L +S Sbjct: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLA--PESD 131 Query: 167 VNWQDKQGWTPL 178 ++ +D G TPL Sbjct: 132 LHHRDASGLTPL 143 >3EHQ-A nrPDB Length = 222 Score = 40.4 bits (93), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 1/89 (1%) Query: 69 DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIE 128 D +G T + AC G+ ++V+ L+ +P +LN+ G T LH A K + ++ Q L+ Sbjct: 103 DKAGSTALYWACHGGHKDIVEMLFTQP-NIELNQQNKLGDTALHAAAWKGYADIVQLLLA 161 Query: 129 NGASVRIKDKFNQIPLHRAASVGSLKLIE 157 GA +++ ++ A + L++ Sbjct: 162 KGARTDLRNIEKKLAFDMATNAACASLLK 190 Score = 32.3 bits (72), Expect = 0.18, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 1/107 (0%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 LH A + + ++N V DK L+ A G ++E+L +N Q Sbjct: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALN 217 +K G T L A +G+ D LL+ K GA DL + + A D+A N Sbjct: 137 NKLGDTALHAAAWKGYADIVQLLLAK-GARTDLRNIEKKLAFDMATN 182 >3T9K-A nrPDB Length = 390 Score = 36.2 bits (82), Expect = 0.011, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 1/70 (1%) Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALA 183 +FL++NGA+V D + PLH A +G L L G + +D +G PL A+ Sbjct: 252 EFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGAD-LGARDSEGRDPLTIAME 310 Query: 184 EGHGDAAVLL 193 + D LL Sbjct: 311 TANADIVTLL 320 Score = 35.0 bits (79), Expect = 0.029, Method: Compositional matrix adjust. Identities = 27/77 (35%), Positives = 36/77 (46%), Gaps = 2/77 (2%) Query: 140 NQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGA 199 N PL +A + SL E L G + VN D G PL HA GH A L + K GA Sbjct: 235 NATPLIQATAANSLLACEFLLQNGAN-VNQADSAGRGPLHHATILGHTGLACLFL-KRGA 292 Query: 200 EYDLVDNKGAKAEDVAL 216 + D++G +A+ Sbjct: 293 DLGARDSEGRDPLTIAM 309 >4BSZ-B nrPDB Length = 202 Score = 35.8 bits (81), Expect = 0.015, Method: Compositional matrix adjust. Identities = 30/129 (23%), Positives = 56/129 (43%), Gaps = 13/129 (10%) Query: 82 VGNLEVVKSLYDRPLKPDL---NKITNQGVTCLHLAVGKKWFEVSQFLIEN--------- 129 G+L+ +K ++ + P+L K + T LH+A E ++++E Sbjct: 24 AGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSAED 83 Query: 130 -GASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGD 188 A V +K LH A+ G L +++LLC ++ ++K G +F A G + Sbjct: 84 LKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIRNKFGHDAIFEAENSGKEE 143 Query: 189 AAVLLVEKY 197 ++KY Sbjct: 144 VETYFLKKY 152 >6DJS-A nrPDB Length = 676 Score = 35.8 bits (81), Expect = 0.017, Method: Compositional matrix adjust. Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 5/84 (5%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 F A GN+ VV+ + + ++N + G L LAVG + EV++ L++ RI Sbjct: 48 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARI 107 Query: 136 KDKFNQIPLHRAASVGSLKLIELL 159 D L A S G ++++E + Sbjct: 108 GD-----ALLLAISKGYVRIVEAI 126 >6CUD-A nrPDB Length = 806 Score = 35.8 bits (81), Expect = 0.018, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 39/79 (49%), Gaps = 5/79 (6%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A GN+ VV+ + + ++N + G L LAVG + EV++ L++ RI D Sbjct: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 Query: 139 FNQIPLHRAASVGSLKLIE 157 L A S G ++++E Sbjct: 93 ----ALLLAISKGYVRIVE 107 >3DEO-A nrPDB Length = 183 Score = 35.4 bits (80), Expect = 0.022, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 4/109 (3%) Query: 42 WSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLN 101 W+ + +A E L +E+ ++D D++G T +G+ + V+ L + D + Sbjct: 49 WTAARKADE--QALSQLLEDRDVDAV-DENGRTALLFVAGLGSDKCVRLLAEAGADLD-H 104 Query: 102 KITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASV 150 + G+T LH+A G EV + L+E GA + ++D+ L A + Sbjct: 105 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREI 153 >3UI2-A nrPDB Length = 244 Score = 35.0 bits (79), Expect = 0.025, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 53/109 (48%), Gaps = 4/109 (3%) Query: 42 WSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLN 101 W+ + +A E L +E+ ++D D++G T +G+ + V+ L + D + Sbjct: 50 WTAARKADE--QALSQLLEDRDVDAV-DENGRTALLFVAGLGSDKCVRLLAEAGADLD-H 105 Query: 102 KITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASV 150 + G+T LH+A G EV + L+E GA + ++D+ L A + Sbjct: 106 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREI 154 >3ZKJ-A nrPDB Length = 261 Score = 34.7 bits (78), Expect = 0.039, Method: Compositional matrix adjust. Identities = 35/129 (27%), Positives = 59/129 (45%), Gaps = 5/129 (3%) Query: 74 TPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASV 133 +P H AC G+L VK L +N +T T L A ++ L+++GASV Sbjct: 38 SPLHEACLGGHLSCVKILLKH--GAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASV 95 Query: 134 RIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 + + P+H AA G ++ + L G + ++ + TPL+ A E A V Sbjct: 96 QPESDLAS-PIHEAARRGHVECVNSLIAYGGN-IDHKISHLGTPLYLA-CENQQRACVKK 152 Query: 194 VEKYGAEYD 202 + + GA+ + Sbjct: 153 LLESGADVN 161 Score = 30.8 bits (68), Expect = 0.47, Method: Compositional matrix adjust. Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 2/74 (2%) Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEG 185 LI G +V I + PLH A G L +++L G + VN TPLF+A G Sbjct: 22 LISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHG-AQVNGVTADWHTPLFNACVSG 80 Query: 186 HGDAAVLLVEKYGA 199 D LL++ +GA Sbjct: 81 SWDCVNLLLQ-HGA 93 >2RFA-A nrPDB Length = 232 Score = 34.3 bits (77), Expect = 0.040, Method: Compositional matrix adjust. Identities = 36/156 (23%), Positives = 60/156 (38%), Gaps = 17/156 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A EN+ + +LL + + Q+ G LH + + E L+ + Sbjct: 6 PLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVF 65 Query: 65 DDYPDD--SGWTPFHIACSVGNLEVVKSLYDRP-------------LKPDLNKITNQGVT 109 + + G T HIA N+ +V++L R +P + + G Sbjct: 66 EPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRP--HNLIYYGEH 123 Query: 110 CLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH 145 L A E+ + LIE+GA +R +D LH Sbjct: 124 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 159 >2NYJ-A nrPDB Length = 273 Score = 33.9 bits (76), Expect = 0.056, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 17/95 (17%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRI--------KDK------FNQIPLHRAASVG 151 +G T LH+A+ ++ + L+ENGA V+ K K F ++PL AA Sbjct: 100 KGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTN 159 Query: 152 SLKLIELLC--GLGKSAVNWQDKQGWTPLFHALAE 184 L +++ L + ++ +D G T + HAL E Sbjct: 160 QLAIVKFLLQNSWQPADISARDSVGNT-VLHALVE 193 >6BBJ-A nrPDB Length = 868 Score = 33.9 bits (76), Expect = 0.064, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 24/138 (17%) Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 +NL+ +D+ IA GNL + + P + + +G T LH+A+ ++ Sbjct: 196 MNLNGGKNDTIPMLIDIAEKTGNL---REFINSPFR----DVYYRGQTALHIAIERRCKH 248 Query: 122 VSQFLIENGASVRIKDK--------------FNQIPLHRAASVGSLKLIELLC--GLGKS 165 + L+E GA V + + F ++PL AA ++ L K+ Sbjct: 249 YVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAHKKA 308 Query: 166 AVNWQDKQGWTPLFHALA 183 + QD +G T L HAL Sbjct: 309 DIRRQDSRGNTVL-HALV 325 >6DMR-A nrPDB Length = 730 Score = 33.5 bits (75), Expect = 0.077, Method: Compositional matrix adjust. Identities = 37/158 (23%), Positives = 63/158 (39%), Gaps = 13/158 (8%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 + + PL QA EN+ ++ LL ++ Q+ G LH + + E + L+ Sbjct: 44 IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 Query: 61 NVNLDDYPDDS--GWTPFHIACSVGNLEVVKSLYDR-----------PLKPDLNKITNQG 107 + + + G T HIA NL +V++L R + + + G Sbjct: 104 ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYG 163 Query: 108 VTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH 145 L A E+ + LIE+GA +R +D LH Sbjct: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 Score = 26.6 bits (57), Expect = 9.8, Method: Compositional matrix adjust. Identities = 27/112 (24%), Positives = 47/112 (41%), Gaps = 14/112 (12%) Query: 63 NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDR---------PLKP---DLNKITNQG--V 108 +L+ P+ G TPF +A GN + + L + PL DL +I + G + Sbjct: 231 SLELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTEIDSWGEEL 290 Query: 109 TCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLC 160 + L L V K E Q L + + K+ + + SL ++ ++C Sbjct: 291 SFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVLASLYILYMIC 342 >3W9G-A nrPDB Length = 260 Score = 33.5 bits (75), Expect = 0.084, Method: Compositional matrix adjust. Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 24/137 (17%) Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 +NL +D+ IA GN+ + + P + + +G T LH+A+ ++ Sbjct: 55 LNLSAGRNDTIPILLDIAEKTGNM---REFINSPFR----DVYYRGQTALHIAIERRCKH 107 Query: 122 VSQFLIENGASVRIKDK--------------FNQIPLHRAASVGSLKLIELLC--GLGKS 165 + L+E GA V + + F ++PL AA ++ L G ++ Sbjct: 108 YVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQA 167 Query: 166 AVNWQDKQGWTPLFHAL 182 + QD +G T L HAL Sbjct: 168 DLRRQDSRGNTVL-HAL 183 >6BOA-A nrPDB Length = 742 Score = 33.1 bits (74), Expect = 0.088, Method: Composition-based stats. Identities = 44/205 (21%), Positives = 76/205 (37%), Gaps = 23/205 (11%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A +N+ + +LL + + Q+ G LH + + E L+ + Sbjct: 48 PLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVF 107 Query: 65 DDYPDD--SGWTPFHIACSVGNLEVVKSLYDR-----------PLKPDLNKITNQGVTCL 111 + + G T HIA N+ +V++L R + + G L Sbjct: 108 EPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPL 167 Query: 112 HLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH----RAASVGSLKLIELLCGLGKSAV 167 A E+ + LIE+GA +R +D LH + + ++ LL + Sbjct: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGD 227 Query: 168 NWQ------DKQGWTPLFHALAEGH 186 + Q + QG TP A EG+ Sbjct: 228 HLQPLDLVPNHQGLTPFKLAGVEGN 252 >5IRX-A nrPDB Length = 636 Score = 33.1 bits (74), Expect = 0.095, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 17/95 (17%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRI--------KDK------FNQIPLHRAASVG 151 +G T LH+A+ ++ + L+ENGA V+ K K F ++PL AA Sbjct: 95 KGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTN 154 Query: 152 SLKLIELLC--GLGKSAVNWQDKQGWTPLFHALAE 184 L +++ L + ++ +D G T L HAL E Sbjct: 155 QLAIVKFLLQNSWQPADISARDSVGNTVL-HALVE 188 >6C8G-A nrPDB Length = 675 Score = 32.7 bits (73), Expect = 0.13, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 24/138 (17%) Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 +NL+ +D+ IA GNL + + P + + +G T LH+A+ ++ Sbjct: 65 MNLNGGKNDTIPMLIDIAEKTGNL---REFINSPFR----DVYYRGQTALHIAIERRCKH 117 Query: 122 VSQFLIENGASVRIKDK--------------FNQIPLHRAASVGSLKLIELLC--GLGKS 165 + L+E GA V + + F ++PL AA ++ L K+ Sbjct: 118 YVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAHKKA 177 Query: 166 AVNWQDKQGWTPLFHALA 183 + QD +G T L HAL Sbjct: 178 DIRRQDSRGNTVL-HALV 194 >5U0K-A nrPDB Length = 141 Score = 32.0 bits (71), Expect = 0.25, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 1/52 (1%) Query: 109 TCLHLAVGKKWFEVSQFLIEN-GASVRIKDKFNQIPLHRAASVGSLKLIELL 159 T LH+A + EV +FLIE + KD++ IPL A L++++LL Sbjct: 60 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 30.0 bits (66), Expect = 0.95, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 4/64 (6%) Query: 31 QKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDS-GWTPFHIACSVGNLEVVK 89 QKD D R LH + + E+ FL+ E ++ + D G P A +LEVVK Sbjct: 53 QKDYDSRTALHVAAAEGHIEVVKFLI---EACKVNPFAKDRWGNIPLDDAVQFNHLEVVK 109 Query: 90 SLYD 93 L D Sbjct: 110 LLQD 113 >6E2G-A nrPDB Length = 727 Score = 31.6 bits (70), Expect = 0.27, Method: Composition-based stats. Identities = 37/156 (23%), Positives = 59/156 (37%), Gaps = 17/156 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A EN + +LL + + QK G LH + + E L+ + Sbjct: 48 PLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVF 107 Query: 65 DDYPDD--SGWTPFHIACSVGNLEVVKSLYDRP-------------LKPDLNKITNQGVT 109 + + G T HIA N+ +V++L R +P + + G Sbjct: 108 EPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRP--HNLIYYGEH 165 Query: 110 CLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH 145 L A E+ + LIE+GA +R +D LH Sbjct: 166 PLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLH 201 >2ETB-A nrPDB Length = 256 Score = 31.6 bits (70), Expect = 0.32, Method: Compositional matrix adjust. Identities = 12/31 (38%), Positives = 21/31 (67%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRIK 136 QG + LH+A+ K+ + + L+ENGA V ++ Sbjct: 89 QGHSALHIAIEKRSLQCVKLLVENGADVHLR 119 >6CV9-A nrPDB Length = 842 Score = 31.2 bits (69), Expect = 0.37, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 40/84 (47%), Gaps = 5/84 (5%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 F A GN+ VV+ + + ++N + G L LAV + E+++ L++ R+ Sbjct: 13 FLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRV 72 Query: 136 KDKFNQIPLHRAASVGSLKLIELL 159 D L A S G ++++E + Sbjct: 73 GD-----ALLLAISKGYVRIVEAI 91 >5HI9-A nrPDB Length = 770 Score = 31.2 bits (69), Expect = 0.42, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 13/67 (19%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRIKD-------------KFNQIPLHRAASVGS 152 QG + LH+A+ K+ + + L+ENGA V ++ F ++PL AA Sbjct: 163 QGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQ 222 Query: 153 LKLIELL 159 ++ L Sbjct: 223 WDVVTYL 229 >6OO7-A nrPDB Length = 786 Score = 30.8 bits (68), Expect = 0.45, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 50/110 (45%), Gaps = 19/110 (17%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRIKD-------------KFNQIPLHRAASVGS 152 +G + LH+A+ K+ + + L+ENGA+V K F ++PL AA Sbjct: 161 RGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQ 220 Query: 153 LKLIELLC--GLGKSAVNWQDKQGWTPLFHAL---AEGHGDAAVLLVEKY 197 ++ L +++ QD G T + HAL A+ + + L+V Y Sbjct: 221 WDVVNYLLENPHQPASLQAQDSLGNT-VLHALVMIADDSAENSALVVRMY 269 >2F37-A nrPDB Length = 251 Score = 30.8 bits (68), Expect = 0.47, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 16/92 (17%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRIKD-------------KFNQIPLHRAASVGS 152 +G + LH+A+ K+ + + L+ENGA+V + F ++PL AA Sbjct: 94 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 153 Query: 153 LKLIELLCGLGKSAVNWQ--DKQGWTPLFHAL 182 ++ L + Q D QG T + HAL Sbjct: 154 WDVVSYLLENPHQPASLQATDSQGNT-VLHAL 184 >6BO5-A nrPDB Length = 695 Score = 30.8 bits (68), Expect = 0.48, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 13/67 (19%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRIKD-------------KFNQIPLHRAASVGS 152 QG + LH+A+ K+ + + L+ENGA V ++ F ++PL AA Sbjct: 123 QGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQ 182 Query: 153 LKLIELL 159 ++ L Sbjct: 183 WDVVTYL 189 >5AN8-A nrPDB Length = 613 Score = 29.6 bits (65), Expect = 0.98, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 19/110 (17%) Query: 106 QGVTCLHLAVGKKWFEVSQFLIENGASVRIKD-------------KFNQIPLHRAASVGS 152 +G + LH+A+ K+ + + L+ENGA+V K F ++PL AA Sbjct: 86 RGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQ 145 Query: 153 LKLIELLCGLGKSAVNW--QDKQGWTPLFHAL---AEGHGDAAVLLVEKY 197 ++ L A + QD G T L HAL A+ + + L+V Y Sbjct: 146 WDVVNYLLENPHPAASLQAQDSLGNTVL-HALVMIADNSPENSALVVRMY 194 >5UQE-A nrPDB Length = 520 Score = 28.1 bits (61), Expect = 3.3, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 35/68 (51%), Gaps = 5/68 (7%) Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGW--TPLFHALAEGHGDAAVLL 193 +D ++ LH AA+ G +++++ L L VN K W TP+ AL GH D +L Sbjct: 446 RDYDSRTALHVAAAEGHVEVVKFL--LEACKVNPFPKDRWNNTPMDEALHFGHHDVFKIL 503 Query: 194 VEKYGAEY 201 E Y +Y Sbjct: 504 QE-YQVQY 510 Score = 27.7 bits (60), Expect = 4.0, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 6/63 (9%) Query: 31 QKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGW--TPFHIACSVGNLEVV 88 Q+D D R LH + + E+ FLL E ++ +P D W TP A G+ +V Sbjct: 445 QRDYDSRTALHVAAAEGHVEVVKFLL---EACKVNPFPKDR-WNNTPMDEALHFGHHDVF 500 Query: 89 KSL 91 K L Sbjct: 501 KIL 503 >5U0J-A nrPDB Length = 140 Score = 27.7 bits (60), Expect = 3.7, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 6/63 (9%) Query: 31 QKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGW--TPFHIACSVGNLEVV 88 Q+D D R LH + + E+ FLL E ++ +P D W TP A G+ +V Sbjct: 52 QRDYDSRTALHVAAAEGHVEVVKFLL---EACKVNPFPKDR-WNNTPMDEALHFGHHDVF 107 Query: 89 KSL 91 K L Sbjct: 108 KIL 110 Score = 27.7 bits (60), Expect = 4.4, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 1/66 (1%) Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVE 195 +D ++ LH AA+ G +++++ L K +D+ TP+ AL GH D +L E Sbjct: 53 RDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQE 112 Query: 196 KYGAEY 201 Y +Y Sbjct: 113 -YQVQY 117 Score = 27.3 bits (59), Expect = 5.8, Method: Compositional matrix adjust. Identities = 17/62 (27%), Positives = 30/62 (48%), Gaps = 1/62 (1%) Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIEN-GASVRIKDKFNQIPLHRAASVGSLKLIE 157 D+ + T LH+A + EV +FL+E + KD++N P+ A G + + Sbjct: 49 DMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFK 108 Query: 158 LL 159 +L Sbjct: 109 IL 110 >3T6Q-C nrPDB Length = 145 Score = 27.3 bits (59), Expect = 5.5, Method: Compositional matrix adjust. Identities = 15/32 (46%), Positives = 20/32 (62%), Gaps = 2/32 (6%) Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 D+ ++GW P H AC+ G LEVV D PL+ Sbjct: 1 DHGSENGW-PKHTACNSGGLEVVYQSCD-PLQ 30 >3M7O-A nrPDB Length = 162 Score = 27.3 bits (59), Expect = 5.8, Method: Compositional matrix adjust. Identities = 15/32 (46%), Positives = 20/32 (62%), Gaps = 2/32 (6%) Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 D+ ++GW P H AC+ G LEVV D PL+ Sbjct: 20 DHGSENGW-PKHTACNSGGLEVVYQSCD-PLQ 49 >5I1T-A nrPDB Length = 330 Score = 26.9 bits (58), Expect = 7.1, Method: Compositional matrix adjust. Identities = 19/82 (23%), Positives = 37/82 (45%), Gaps = 1/82 (1%) Query: 11 MENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLS-KMENVNLDDYPD 69 ++N++ K+QE + ++ + +PL++S S E + + S K + + P Sbjct: 140 IKNKYSKIQEAVRGTKGQIITYNDKAILPLYFSTSSGKTENSEEVFSAKYPYLKSVESPY 199 Query: 70 DSGWTPFHIACSVGNLEVVKSL 91 D F + N + VKSL Sbjct: 200 DKYSPKFASTLKISNTDFVKSL 221 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1WG0-A nrPDB 270 4e-73 4OAU-C nrPDB 214 2e-56 5JHQ-A nrPDB 206 6e-54 2DWZ-A nrPDB 203 4e-53 3EU9-A nrPDB 202 8e-53 4NIK-A nrPDB 201 2e-52 4O1O-A nrPDB 198 1e-51 5AQ9-A nrPDB 185 1e-47 5AQA-A nrPDB 181 3e-46 5AQB-A nrPDB 173 5e-44 5MIO-C nrPDB 171 2e-43 5AQ7-A nrPDB 171 2e-43 6EMK-G nrPDB 170 6e-43 6MWQ-A nrPDB 169 1e-42 6BY9-A nrPDB 167 3e-42 5H76-A nrPDB 164 2e-41 6FES-A nrPDB 163 7e-41 5ET1-A nrPDB 162 8e-41 3B7B-A nrPDB 162 1e-40 3LJN-A nrPDB 162 1e-40 6AUN-A nrPDB 154 4e-38 5HKP-A nrPDB 152 1e-37 5GP7-A nrPDB 144 2e-35 4Z68-A nrPDB 142 2e-34 4OT9-A nrPDB 135 1e-32 5CBO-A nrPDB 134 2e-32 5D68-A nrPDB 110 3e-25 1G3N-B nrPDB 110 5e-25 2KXP-C nrPDB 103 7e-23 1BD8-A nrPDB 102 1e-22 3EHQ-A nrPDB 100 4e-22 1BLX-B nrPDB 99 2e-21 Sequences not found previously or not previously below threshold: 3ZKJ-A nrPDB 128 3e-30 6E2G-A nrPDB 100 5e-22 6DMR-A nrPDB 96 1e-20 2RFA-A nrPDB 93 8e-20 6BOA-A nrPDB 93 8e-20 3T9K-A nrPDB 78 3e-15 4BSZ-B nrPDB 74 4e-14 5DND-A nrPDB 74 7e-14 1D9S-A nrPDB 72 1e-13 2A5E-A nrPDB 71 3e-13 3UI2-A nrPDB 70 6e-13 3DEO-A nrPDB 70 8e-13 6OO7-A nrPDB 67 4e-12 5AN8-A nrPDB 67 9e-12 6DVZ-A nrPDB 65 3e-11 6BO5-A nrPDB 65 4e-11 5HI9-A nrPDB 65 4e-11 2F37-A nrPDB 64 7e-11 5U0K-A nrPDB 63 9e-11 4N5Q-A nrPDB 63 1e-10 5IRX-A nrPDB 62 2e-10 2ETB-A nrPDB 62 2e-10 6CUD-A nrPDB 61 4e-10 2NYJ-A nrPDB 61 5e-10 4XD0-A nrPDB 60 6e-10 3W9G-A nrPDB 60 7e-10 1DCQ-A nrPDB 60 9e-10 3LVQ-E nrPDB 60 9e-10 6DJS-A nrPDB 60 1e-09 5UQE-A nrPDB 60 1e-09 2B0O-E nrPDB 58 3e-09 6CV9-A nrPDB 58 4e-09 4DX2-A nrPDB 57 5e-09 5U0J-A nrPDB 56 1e-08 6C8G-A nrPDB 55 2e-08 6BBJ-A nrPDB 55 2e-08 6MHW-A nrPDB 52 2e-07 6G1K-A nrPDB 50 7e-07 5UIL-A nrPDB 44 5e-05 6BWI-A nrPDB 36 0.014 5Z96-A nrPDB 34 0.049 2DI3-A nrPDB 31 0.36 1HXH-A nrPDB 30 0.81 4CJ9-A nrPDB 29 1.7 1OH2-P nrPDB 29 1.8 4DNA-A nrPDB 29 2.2 3RJ4-A nrPDB 28 2.6 4WVX-A nrPDB 28 3.1 4TWE-A nrPDB 28 3.2 2I3A-A nrPDB 28 4.3 6HRH-B nrPDB 27 5.1 >1WG0-A nrPDB Length = 243 Score = 270 bits (690), Expect = 4e-73, Method: Composition-based stats. Identities = 228/228 (100%), Positives = 228/228 (100%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME Sbjct: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF Sbjct: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH Sbjct: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV 228 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV Sbjct: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV 228 >4OAU-C nrPDB Length = 699 Score = 214 bits (546), Expect = 2e-56, Method: Composition-based stats. Identities = 54/231 (23%), Positives = 101/231 (43%), Gaps = 18/231 (7%) Query: 2 SNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61 N+ L +A + VQ+LL ++ Q+++ G PLH +V +I LL + Sbjct: 5 DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD 64 Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 L +G TPF +A G+++++K + D+N+ G T A + Sbjct: 65 PVLRK---KNGATPFILAAIAGSVKLLKLFLSKG--ADVNECDFYGFTAFMEAAVYGKVK 119 Query: 122 VSQFLIENGASVRIK----------DKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQD 171 +FL + GA+V ++ K L AA G ++++++L + VN D Sbjct: 120 ALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACD 179 Query: 172 KQGWTPLFHAL---AEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQ 219 G L HAL + +A L+ +GA+ ++ +G +A+ ++ Sbjct: 180 NMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 230 Score = 85.9 bits (211), Expect = 1e-17, Method: Composition-based stats. Identities = 42/176 (23%), Positives = 71/176 (40%), Gaps = 13/176 (7%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPL-HWSVSFQAHE---ITSFLLSKMEN 61 L A + ++ LL + + D GR L H +S + IT LL + Sbjct: 152 LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD 211 Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 VN+ + G TP +A +L +V+ L ++ ++N + G T L LAV K + Sbjct: 212 VNVR---GERGKTPLILAVEKKHLGLVQRLLEQE-HIEINDTDSDGKTALLLAVELKLKK 267 Query: 122 VSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTP 177 +++ L + GAS D + A L+++L G + W P Sbjct: 268 IAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKP 318 Score = 43.5 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 21/95 (22%), Positives = 33/95 (34%), Gaps = 8/95 (8%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A + VQ LL + + D DG+ L +V + +I L + + + Sbjct: 222 PLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 281 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 D + H +VK L K D Sbjct: 282 GDLVMTARRNYDH--------SLVKVLLSHGAKED 308 Score = 30.4 bits (67), Expect = 0.71, Method: Composition-based stats. Identities = 11/54 (20%), Positives = 20/54 (37%), Gaps = 5/54 (9%) Query: 178 LFHALAEGHGDAAVLLVEKYGAEYDLVDNKGA-KAEDVALN---EQVKKFFLNN 227 L A+ D L+E GA + + +G A+ E + + L + Sbjct: 9 LIKAVQNEDVDLVQQLLE-GGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 61 >5JHQ-A nrPDB Length = 482 Score = 206 bits (525), Expect = 6e-54, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 107/272 (39%), Gaps = 58/272 (21%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL ++ +D G IPLH + SF E+ S LL + + N Sbjct: 52 PLHFAAGFGRKDVVEHLLQMGANVH-ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 110 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDL------------------------ 100 D+ +TP H A G ++V L P++ Sbjct: 111 R---DNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEY 167 Query: 101 ----------------------------NKITNQGVTCLHLAVGKKWFEVSQFLIENGAS 132 + + T LHLA G + Q L+++GA Sbjct: 168 KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 227 Query: 133 VRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVL 192 V KDK +PLH A S G ++ ELL G + VN D +TPL A ++ + L Sbjct: 228 VHAKDKGGLVPLHNACSYGHYEVTELLLKHG-ACVNAMDLWQFTPLHEAASKNRVEVCSL 286 Query: 193 LVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 L+ +GA+ LV+ G A D+A ++++ Sbjct: 287 LLS-HGADPTLVNCHGKSAVDMAPTPELRERL 317 Score = 150 bits (380), Expect = 3e-37, Method: Composition-based stats. Identities = 62/247 (25%), Positives = 96/247 (38%), Gaps = 33/247 (13%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGR--IPLHWSVSFQAHEITSFLLSKMENVN 63 L +AC + +V+ L+ + + KD GR PLH++ F ++ LL NV+ Sbjct: 19 LLEACRNGDVSRVKRLV--DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 76 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 DD G P H ACS G+ EVV L + P N N T LH A K +V Sbjct: 77 AR---DDGGLIPLHNACSFGHAEVVSLLLCQGADP--NARDNWNYTPLHEAAIKGKIDVC 131 Query: 124 QFLIENGASVRIKDKFNQIPLHR--------------------AASVGSLKLIELLCGLG 163 L+++GA I++ + L AA G+ + + L Sbjct: 132 IVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPL 191 Query: 164 KSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALN---EQV 220 + D + TPL A LL++ +GA+ D G A + +V Sbjct: 192 NVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGHYEV 250 Query: 221 KKFFLNN 227 + L + Sbjct: 251 TELLLKH 257 Score = 139 bits (350), Expect = 1e-33, Method: Composition-based stats. Identities = 72/275 (26%), Positives = 103/275 (37%), Gaps = 62/275 (22%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N VQ LL + KD+ G +PLH + S+ +E+T LL VN Sbjct: 205 PLHLAAGYNRVRIVQLLLQHGADVH-AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 263 Query: 65 DDYPDDSGWTPFHIACSVGNLEVV------------------------------------ 88 D +TP H A S +EV Sbjct: 264 MDL---WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 320 Query: 89 ---KSLYDRPLKPDLNKITNQGV-------------TCLHLAVGKKWF---EVSQFLIEN 129 SL + DL K+ T LH AV +V++ L+ Sbjct: 321 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 380 Query: 130 GASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDA 189 GA+V K+K PLH AA ++E+L G + +N D G T L A GH Sbjct: 381 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG-AKMNALDTLGQTALHRAALAGHLQT 439 Query: 190 AVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 LL+ YG++ ++ +G A + NE V++ Sbjct: 440 CRLLLS-YGSDPSIISLQGFTAAQMG-NEAVQQIL 472 >2DWZ-A nrPDB Length = 231 Score = 203 bits (517), Expect = 4e-53, Method: Composition-based stats. Identities = 73/216 (33%), Positives = 110/216 (50%), Gaps = 7/216 (3%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 +SN + + +++E + + SL + DQD R LHW+ S EI FLL Sbjct: 5 VSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 VN DD+GW+P HIA S G E+VK+L + +N + G T LH A K Sbjct: 65 PVN---DKDDAGWSPLHIAASAGRDEIVKALLVKGAH--VNAVNQNGCTPLHYAASKNRH 119 Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 E++ L+E GA+ KD ++ +HRAA+ G+LK++ +L K++ N QD +G TPL Sbjct: 120 EIAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILL-FYKASTNIQDTEGNTPLHL 178 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL 216 A E + A LV + GA + + + VA Sbjct: 179 ACDEERVEEAKFLVTQ-GASIYIENKEEKTPLQVAK 213 Score = 75.5 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 3/110 (2%) Query: 115 VGKKWF-EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 E+ + ++ + + D+ ++ LH A S G +++E L LG VN +D Sbjct: 14 AYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDA 72 Query: 174 GWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKF 223 GW+PL A + G + L+ K GA + V+ G A ++ + Sbjct: 73 GWSPLHIAASAGRDEIVKALLVK-GAHVNAVNQNGCTPLHYAASKNRHEI 121 >3EU9-A nrPDB Length = 240 Score = 202 bits (515), Expect = 8e-53, Method: Composition-based stats. Identities = 65/228 (28%), Positives = 99/228 (43%), Gaps = 11/228 (4%) Query: 2 SNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61 S + + +A + + +EL+ + + Q D++ LHW+ ++ + +SK Sbjct: 9 STWDIVKATQYGIYERCRELVEAGYDVR-QPDKENVTLLHWAAINNRIDLVKYYISKGAI 67 Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 V D D TP H A G+L +V L P L I +G +C+HLA Sbjct: 68 V--DQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSL--IDGEGCSCIHLAAQFGHTS 123 Query: 122 VSQFLIENGASVRIKDKFNQIPLHRAA-SVGSLKLIELLCGLGKSAVNWQDKQG-WTPLF 179 + +LI G V + D+ PL AA S+ LL S VN DK T L Sbjct: 124 IVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVS-VNLGDKYHKNTALH 182 Query: 180 HALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNN 227 A+ G+ LL+E GA D + KG A D+A +Q K ++ N Sbjct: 183 WAVLAGNTTVISLLLEA-GANVDAQNIKGESALDLA--KQRKNVWMIN 227 >4NIK-A nrPDB Length = 230 Score = 201 bits (512), Expect = 2e-52, Method: Composition-based stats. Identities = 75/216 (34%), Positives = 111/216 (51%), Gaps = 7/216 (3%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 +SN + + +++E + + SL + DQD R LHW+ S EI FLL Sbjct: 9 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 68 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 VN DD+GW+P HIA S G E+VK+L + + +N + G T LH A K Sbjct: 69 PVN---DKDDAGWSPLHIAASAGRDEIVKALLGKGAQ--VNAVNQNGCTPLHYAASKNRH 123 Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 E++ L+E GA+ KD + +HRAA+ G+LK+I +L K++ N QD +G TPL Sbjct: 124 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHL 182 Query: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL 216 A E + A LLV + GA + + + VA Sbjct: 183 ACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQVAK 217 Score = 76.6 bits (187), Expect = 7e-15, Method: Composition-based stats. Identities = 27/110 (24%), Positives = 50/110 (45%), Gaps = 3/110 (2%) Query: 115 VGKKWFE-VSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 E + + ++ + + D+ ++ LH A S G +++E L LG VN +D Sbjct: 18 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDA 76 Query: 174 GWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKF 223 GW+PL A + G + L+ K GA+ + V+ G A ++ + Sbjct: 77 GWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEI 125 >4O1O-A nrPDB Length = 717 Score = 198 bits (504), Expect = 1e-51, Method: Composition-based stats. Identities = 60/238 (25%), Positives = 101/238 (42%), Gaps = 21/238 (8%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 L QA E + +V++LL Q+++ G PLH +V + ++ + LL + L Sbjct: 11 MLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCL 70 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 +G TPF IA GN+ +++ L P D+N+ G T A E + Sbjct: 71 RKR---NGATPFIIAGITGNVRLLQLLL--PNVEDVNECDVNGFTAFMEAAVYGRVEALR 125 Query: 125 FLIENGASVRI-----KDKF-----NQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQG 174 FL ENGA V + +D+ L AA G + ++ +L K+ V+ +D G Sbjct: 126 FLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMG 185 Query: 175 WTPLFHAL---AEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA---LNEQVKKFFLN 226 L +AL +G A L+ +GA+ ++ +A N + + L Sbjct: 186 RNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLE 243 Score = 77.0 bits (188), Expect = 6e-15, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 69/178 (38%), Gaps = 17/178 (9%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHE----ITSFLLSKMEN 61 L A + V LLH+ + + +D GR L +++ IT LL + Sbjct: 155 LMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGAD 214 Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFE 121 VN+ TP +A NL++V+ L ++ ++N +G T L LAV + E Sbjct: 215 VNVRGEGSK---TPLILAVERKNLDLVQMLLEQEQ-IEVNDTDREGKTALLLAVELRLEE 270 Query: 122 VSQFLIENGASVRIKDKFNQIPLHRAASVGSL--KLIELLCGLGKSAVNWQDKQGWTP 177 +++ L GAS D A + + L++ L + W P Sbjct: 271 IAKLLCHRGASTNCGDL-------VAIARRNYDSDLVKFLRLHKAGEDFRPPAENWKP 321 Score = 42.7 bits (99), Expect = 1e-04, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 35/98 (35%), Gaps = 8/98 (8%) Query: 2 SNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61 S PL A VQ LL + + D++G+ L +V + EI L + + Sbjct: 222 SKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGAS 281 Query: 62 VNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 N D IA + ++VK L D Sbjct: 282 TNCGDLVA--------IARRNYDSDLVKFLRLHKAGED 311 >5AQ9-A nrPDB Length = 422 Score = 185 bits (469), Expect = 1e-47, Method: Composition-based stats. Identities = 55/165 (33%), Positives = 79/165 (47%), Gaps = 7/165 (4%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 GR L + + L++ +VN D++G TP H+A G+LE+V+ L Sbjct: 15 GRKLLE-AARAGQDDEVRILMANGADVNA---ADNTGTTPLHLAAYSGHLEIVEVLLKHG 70 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D++ G T LHLA E+ + L++NGA V D PLH AA G L++ Sbjct: 71 --ADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEI 128 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAE 200 +E+L G + VN QDK G TP A G+ D LL A+ Sbjct: 129 VEVLLKHG-ADVNAQDKFGKTPFDLADDNGNDDVGTLLQVAAAAD 172 Score = 167 bits (423), Expect = 3e-42, Method: Composition-based stats. Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 4/139 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N N G T LHLA E+ + L+++GA V D Sbjct: 21 AARAGQDDEVRILMANG--ADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDV 78 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 F PLH AA G L+++E+L G + VN D G TPL A G+ + +L+ K+G Sbjct: 79 FGYTPLHLAAYWGHLEIVEVLLKNG-ADVNAMDSDGMTPLHLAAKWGYLEIVEVLL-KHG 136 Query: 199 AEYDLVDNKGAKAEDVALN 217 A+ + D G D+A + Sbjct: 137 ADVNAQDKFGKTPFDLADD 155 Score = 162 bits (409), Expect = 1e-40, Method: Composition-based stats. Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 6/161 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ L+ + + D G PLH + EI LL +V Sbjct: 18 LLEAARAGQDDEVRILMANGADVN-AADNTGTTPLHLAAYSGHLEIVEVLLKHGADV--- 73 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D D G+TP H+A G+LE+V+ L D+N + + G+T LHLA + E+ + Sbjct: 74 DASDVFGYTPLHLAAYWGHLEIVEVLLKNG--ADVNAMDSDGMTPLHLAAKWGYLEIVEV 131 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 L+++GA V +DKF + P A G+ + LL + Sbjct: 132 LLKHGADVNAQDKFGKTPFDLADDNGNDDVGTLLQVAAAAD 172 Score = 116 bits (290), Expect = 9e-27, Method: Composition-based stats. Identities = 38/129 (29%), Positives = 49/129 (37%), Gaps = 7/129 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL + D G PLH + + EI LL +VN Sbjct: 50 PLHLAAYSGHLEIVEVLLKHGADV-DASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNA 108 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D G TP H+A G LE+V+ L D+N G T LA +V Sbjct: 109 M---DSDGMTPLHLAAKWGYLEIVEVLLKHG--ADVNAQDKFGKTPFDLADDNGNDDVGT 163 Query: 125 FL-IENGAS 132 L + A Sbjct: 164 LLQVAAAAD 172 >5AQA-A nrPDB Length = 418 Score = 181 bits (458), Expect = 3e-46, Method: Composition-based stats. Identities = 53/161 (32%), Positives = 79/161 (49%), Gaps = 7/161 (4%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 GR L + + L++ +VN D++G TP H+A G+LE+V+ L Sbjct: 15 GRKLLE-AARAGQDDEVRILMANGADVNA---ADNTGTTPLHLAAYSGHLEIVEVLLKHG 70 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D++ G T LHLA E+ + L++NGA V D PLH AA G ++ Sbjct: 71 --ADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEI 128 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 +E+L G + V+ QDK G PL+ A +GH + A LV Sbjct: 129 VEVLLKAG-ADVDAQDKFGKRPLWLAADQGHAEIAAKLVAA 168 Score = 161 bits (408), Expect = 2e-40, Method: Composition-based stats. Identities = 47/145 (32%), Positives = 70/145 (48%), Gaps = 4/145 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N N G T LHLA E+ + L+++GA V D Sbjct: 21 AARAGQDDEVRILMANG--ADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDV 78 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 F PLH AA G L+++E+L G + VN D G TPL A G+ + +L+ K G Sbjct: 79 FGYTPLHLAAYWGHLEIVEVLLKNG-ADVNAMDSDGMTPLHLAAKWGYKEIVEVLL-KAG 136 Query: 199 AEYDLVDNKGAKAEDVALNEQVKKF 223 A+ D D G + +A ++ + Sbjct: 137 ADVDAQDKFGKRPLWLAADQGHAEI 161 Score = 159 bits (402), Expect = 1e-39, Method: Composition-based stats. Identities = 48/155 (30%), Positives = 75/155 (48%), Gaps = 6/155 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ L+ + + D G PLH + EI LL +V Sbjct: 18 LLEAARAGQDDEVRILMANGADVN-AADNTGTTPLHLAAYSGHLEIVEVLLKHGADV--- 73 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D D G+TP H+A G+LE+V+ L D+N + + G+T LHLA + E+ + Sbjct: 74 DASDVFGYTPLHLAAYWGHLEIVEVLLKNG--ADVNAMDSDGMTPLHLAAKWGYKEIVEV 131 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLC 160 L++ GA V +DKF + PL AA G ++ L Sbjct: 132 LLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLV 166 Score = 81.6 bits (200), Expect = 2e-16, Method: Composition-based stats. Identities = 28/96 (29%), Positives = 38/96 (39%), Gaps = 4/96 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL + + D DG PLH + + EI LL +V Sbjct: 83 PLHLAAYWGHLEIVEVLLKNGADVNAM-DSDGMTPLHLAAKWGYKEIVEVLLKAGADV-- 139 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDL 100 D D G P +A G+ E+ L LK + Sbjct: 140 -DAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARV 174 >5AQB-A nrPDB Length = 428 Score = 173 bits (439), Expect = 5e-44, Method: Composition-based stats. Identities = 56/158 (35%), Positives = 81/158 (51%), Gaps = 8/158 (5%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 G+ L + + Q E L++ +VN D+ GWTP H+A G+LE+V+ L Sbjct: 15 GKKLLEAARAGQDDEC-RILMANGADVNA---LDEVGWTPLHLAAW-GHLEIVECLLKNG 69 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D+N G T LHLA E+ + L++ GA V D+ PLH AA G L++ Sbjct: 70 --ADVNAADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEI 127 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 +E+L G + VN QDK G TP A+ G+ D A +L Sbjct: 128 VEVLLKNG-ADVNAQDKFGKTPRDLAIDNGNEDIAEVL 164 Score = 160 bits (406), Expect = 3e-40, Method: Composition-based stats. Identities = 47/154 (30%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + + + L+ + + D+ G PLH + + EI LL +VN Sbjct: 18 LLEAARAGQDDECRILMANGADVN-ALDEVGWTPLHLAA-WGHLEIVECLLKNGADVNAA 75 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D G+TP H+A G+LE+V+ L D+N G T LHLA E+ + Sbjct: 76 DID---GYTPLHLAAFSGHLEIVEVLLKYG--ADVNADDQAGFTPLHLAAIFGHLEIVEV 130 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 L++NGA V +DKF + P A G+ + E+L Sbjct: 131 LLKNGADVNAQDKFGKTPRDLAIDNGNEDIAEVL 164 Score = 160 bits (406), Expect = 3e-40, Method: Composition-based stats. Identities = 48/149 (32%), Positives = 72/149 (48%), Gaps = 8/149 (5%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + + L D+N + G T LHLA E+ + L++NGA V D Sbjct: 21 AARAGQDDECRILMANG--ADVNALDEVGWTPLHLAAW-GHLEIVECLLKNGADVNAADI 77 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 PLH AA G L+++E+L G + VN D+ G+TPL A GH + +L+ K G Sbjct: 78 DGYTPLHLAAFSGHLEIVEVLLKYG-ADVNADDQAGFTPLHLAAIFGHLEIVEVLL-KNG 135 Query: 199 AEYDLVDNKGAKAEDVAL---NEQVKKFF 224 A+ + D G D+A+ NE + + Sbjct: 136 ADVNAQDKFGKTPRDLAIDNGNEDIAEVL 164 Score = 118 bits (296), Expect = 2e-27, Method: Composition-based stats. Identities = 46/151 (30%), Positives = 69/151 (45%), Gaps = 11/151 (7%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL + + D DG PLH + EI LL +VN Sbjct: 50 PLHLAAW-GHLEIVECLLKNGADVN-AADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNA 107 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D D +G+TP H+A G+LE+V+ L D+N G T LA+ ++++ Sbjct: 108 D---DQAGFTPLHLAAIFGHLEIVEVLLKNG--ADVNAQDKFGKTPRDLAIDNGNEDIAE 162 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 L + V++KD +Q A VG ++L Sbjct: 163 VLGKAATLVKVKDAADQ----LGARVGYIEL 189 >5MIO-C nrPDB Length = 573 Score = 171 bits (434), Expect = 2e-43, Method: Composition-based stats. Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 7/149 (4%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N G+T LHLA E+ + L+++GA V D Sbjct: 417 AARAGQDDEVRVLMANG--ADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASDL 474 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 PLH AA +G L+++E+L G + VN D G TPL A GH L+ K+G Sbjct: 475 MGSTPLHLAALIGHLEIVEVLLKHG-ADVNAVDTWGDTPLRLAAVMGHLKIVEALL-KHG 532 Query: 199 AEYDLVDNKGAKAEDVALN---EQVKKFF 224 A+ + D G A D +++ E + + Sbjct: 533 ADVNAQDKFGKTAYDTSIDNGSEDLAEIL 561 Score = 155 bits (393), Expect = 1e-38, Method: Composition-based stats. Identities = 45/158 (28%), Positives = 74/158 (46%), Gaps = 6/158 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ L+ + + D G PLH + ++ EI LL +V+ Sbjct: 414 LLEAARAGQDDEVRVLMANGADVN-ATDASGLTPLHLAATYGHLEIVEVLLKHGADVSAS 472 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D G TP H+A +G+LE+V+ L D+N + G T L LA ++ + Sbjct: 473 DL---MGSTPLHLAALIGHLEIVEVLLKHG--ADVNAVDTWGDTPLRLAAVMGHLKIVEA 527 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG 163 L+++GA V +DKF + + GS L E+L L Sbjct: 528 LLKHGADVNAQDKFGKTAYDTSIDNGSEDLAEILQKLN 565 Score = 122 bits (305), Expect = 2e-28, Method: Composition-based stats. Identities = 35/105 (33%), Positives = 52/105 (49%), Gaps = 2/105 (1%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 L A + + L+ NGA V D PLH AA+ G L+++E+L G + V+ Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHG-ADVSAS 472 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 D G TPL A GH + +L+ K+GA+ + VD G +A Sbjct: 473 DLMGSTPLHLAALIGHLEIVEVLL-KHGADVNAVDTWGDTPLRLA 516 >5AQ7-A nrPDB Length = 418 Score = 171 bits (433), Expect = 2e-43, Method: Composition-based stats. Identities = 52/157 (33%), Positives = 78/157 (49%), Gaps = 6/157 (3%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + LL+ +VN D++G+TP H+A G+L +V+ L D Sbjct: 18 LLEAARAGQDDEVRILLANGADVN---TADETGFTPLHLAAWEGHLGIVEVLLKNG--AD 72 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 +N +G T LHLA E+ + L++NGA V D PLH AA G +++E+L Sbjct: 73 VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVL 132 Query: 160 CGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 G + V+ QDK G PL+ A +GH + A LV Sbjct: 133 LKAG-ADVDAQDKFGKRPLWLAADQGHAEIAAKLVAA 168 Score = 159 bits (401), Expect = 1e-39, Method: Composition-based stats. Identities = 46/155 (29%), Positives = 71/155 (45%), Gaps = 6/155 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ LL + + D+ G PLH + I LL +VN + Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTA-DETGFTPLHLAAWEGHLGIVEVLLKNGADVNAN 76 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D+ G TP H+A G+LE+V+ L +N G LHLA + E+ + Sbjct: 77 ---DERGHTPLHLAAYTGHLEIVEVLLKNGAG--VNATDVIGTAPLHLAAMWGYKEIVEV 131 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLC 160 L++ GA V +DKF + PL AA G ++ L Sbjct: 132 LLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLV 166 Score = 157 bits (397), Expect = 3e-39, Method: Composition-based stats. Identities = 44/145 (30%), Positives = 68/145 (46%), Gaps = 4/145 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N G T LHLA + + + L++NGA V D+ Sbjct: 21 AARAGQDDEVRILLANG--ADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDE 78 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 PLH AA G L+++E+L G + VN D G PL A G+ + +L+ K G Sbjct: 79 RGHTPLHLAAYTGHLEIVEVLLKNG-AGVNATDVIGTAPLHLAAMWGYKEIVEVLL-KAG 136 Query: 199 AEYDLVDNKGAKAEDVALNEQVKKF 223 A+ D D G + +A ++ + Sbjct: 137 ADVDAQDKFGKRPLWLAADQGHAEI 161 Score = 111 bits (277), Expect = 3e-25, Method: Composition-based stats. Identities = 35/124 (28%), Positives = 49/124 (39%), Gaps = 6/124 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A E V+ LL + + D+ G PLH + EI LL VN Sbjct: 50 PLHLAAWEGHLGIVEVLLKNGADVNAN-DERGHTPLHLAAYTGHLEIVEVLLKNGAGVNA 108 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D G P H+A G E+V+ L D++ G L LA + E++ Sbjct: 109 TDVI---GTAPLHLAAMWGYKEIVEVLLKAG--ADVDAQDKFGKRPLWLAADQGHAEIAA 163 Query: 125 FLIE 128 L+ Sbjct: 164 KLVA 167 Score = 73.9 bits (180), Expect = 5e-14, Method: Composition-based stats. Identities = 27/96 (28%), Positives = 37/96 (38%), Gaps = 4/96 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL + + D G PLH + + EI LL +V Sbjct: 83 PLHLAAYTGHLEIVEVLLKNGAGVN-ATDVIGTAPLHLAAMWGYKEIVEVLLKAGADV-- 139 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDL 100 D D G P +A G+ E+ L LK + Sbjct: 140 -DAQDKFGKRPLWLAADQGHAEIAAKLVAARLKARV 174 >6EMK-G nrPDB Length = 426 Score = 170 bits (430), Expect = 6e-43, Method: Composition-based stats. Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 5/179 (2%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKD-QDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 L +A +E V+ LL P LL D ++G LH++ S+ + L ++ + Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYA-SYHGRYLICVYLIQLGHDKH 67 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 + G T H+A G+ + + L + +N G +H+A +++ Sbjct: 68 ELIKTFKGNTCVHLALMKGHEQTLHLLLQQ-FPRFINHRGENGRAPIHIACMNDYYQCLS 126 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAV--NWQDKQGWTPLFHA 181 LI GA + + D PLH GS+ +++L G+ ++ N +DK W P+ A Sbjct: 127 LLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVA 185 Score = 90.9 bits (224), Expect = 4e-19, Method: Composition-based stats. Identities = 34/141 (24%), Positives = 53/141 (37%), Gaps = 3/141 (2%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVR- 134 A GNL +VK L R N + G + LH A + + +LI+ G Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHE 68 Query: 135 -IKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 IK +H A G + + LL +N + + G P+ A + LL Sbjct: 69 LIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLL 128 Query: 194 VEKYGAEYDLVDNKGAKAEDV 214 + GA+ ++D G V Sbjct: 129 IG-VGADLWVMDTNGDTPLHV 148 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 39/112 (34%), Gaps = 3/112 (2%) Query: 111 LHLAVGKKWFEVSQFLIENGAS--VRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVN 168 L A+ + + + L+ I + LH A+ G + L LG Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHE 68 Query: 169 -WQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQ 219 + +G T + AL +GH LL++++ + G +A Sbjct: 69 LIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMND 120 >6MWQ-A nrPDB Length = 493 Score = 169 bits (427), Expect = 1e-42, Method: Composition-based stats. Identities = 48/149 (32%), Positives = 77/149 (51%), Gaps = 7/149 (4%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N + G+T LHLA + E+ + L++ GA V D Sbjct: 12 AARAGQDDEVRILMANG--ADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADL 69 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 + Q PLH AA+ G L+++E+L G + VN D G TPL +GH + +L+ K+G Sbjct: 70 WGQTPLHLAATAGHLEIVEVLLKYG-ADVNALDLIGKTPLHLTAIDGHLEIVEVLL-KHG 127 Query: 199 AEYDLVDNKGAKAEDVAL---NEQVKKFF 224 A+ + D G A D+++ NE + + Sbjct: 128 ADVNAQDKFGKTAFDISIDNGNEDLAEIL 156 Score = 168 bits (425), Expect = 2e-42, Method: Composition-based stats. Identities = 49/165 (29%), Positives = 76/165 (46%), Gaps = 6/165 (3%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + L++ +VN D G TP H+A G+LE+V+ L D Sbjct: 9 LLEAARAGQDDEVRILMANGADVNA---LDRFGLTPLHLAAQRGHLEIVEVLLK--CGAD 63 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 +N G T LHLA E+ + L++ GA V D + PLH A G L+++E+L Sbjct: 64 VNAADLWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVL 123 Query: 160 CGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLV 204 G + VN QDK G T ++ G+ D A +L + ++ Sbjct: 124 LKHG-ADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLSDIAHR 167 Score = 160 bits (404), Expect = 5e-40, Method: Composition-based stats. Identities = 52/188 (27%), Positives = 82/188 (43%), Gaps = 7/188 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ L+ + + D+ G PLH + EI LL +VN Sbjct: 9 LLEAARAGQDDEVRILMANGADVN-ALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAA 67 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D G TP H+A + G+LE+V+ L D+N + G T LHL E+ + Sbjct: 68 DL---WGQTPLHLAATAGHLEIVEVLLKYG--ADVNALDLIGKTPLHLTAIDGHLEIVEV 122 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEG 185 L+++GA V +DKF + + G+ L E+L L S + + + A E Sbjct: 123 LLKHGADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLSDIAHRIVAPGKGI-LAADES 181 Query: 186 HGDAAVLL 193 G A L Sbjct: 182 TGSIAKRL 189 Score = 112 bits (279), Expect = 2e-25, Method: Composition-based stats. Identities = 33/124 (26%), Positives = 52/124 (41%), Gaps = 6/124 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL + D G+ PLH + + EI LL +VN Sbjct: 41 PLHLAAQRGHLEIVEVLLKCGADVN-AADLWGQTPLHLAATAGHLEIVEVLLKYGADVNA 99 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D G TP H+ G+LE+V+ L D+N G T +++ ++++ Sbjct: 100 LDLI---GKTPLHLTAIDGHLEIVEVLLKHG--ADVNAQDKFGKTAFDISIDNGNEDLAE 154 Query: 125 FLIE 128 L + Sbjct: 155 ILQK 158 >6BY9-A nrPDB Length = 328 Score = 167 bits (423), Expect = 3e-42, Method: Composition-based stats. Identities = 53/211 (25%), Positives = 87/211 (41%), Gaps = 7/211 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A L+ + + + +D R PL + E +L+ V Sbjct: 105 PLHAAAEAGHVDICHMLVQAGAN-IDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALV-- 161 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D D G T H+A G+ EVV+ L D+N + G T + A K ++ + Sbjct: 162 -DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM-DVNCQDDGGWTPMIWATEYKHVDLVK 219 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 L+ G+ + I+D I LH AA G + + E+L K ++ + G +PL A E Sbjct: 220 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA-AKCDLHAVNIHGDSPLHIAARE 278 Query: 185 GHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 D VL + + ++ L + +G A Sbjct: 279 NRYDCVVLFLSRD-SDVTLKNKEGETPLQCA 308 Score = 161 bits (408), Expect = 2e-40, Method: Composition-based stats. Identities = 46/189 (24%), Positives = 78/189 (41%), Gaps = 7/189 (3%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L++S + +L + N + +P H A G++++ L + Sbjct: 71 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNK-RSPLHAAAEAGHVDICHMLVQAG--AN 127 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 ++ + T L A E ++LI+ GA V KD LH AA G ++++ L Sbjct: 128 IDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYL 187 Query: 160 CGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNE- 218 G+ VN QD GWTP+ A H D LL+ K G++ ++ DN+ A Sbjct: 188 LSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSK-GSDINIRDNEENICLHWAAFSG 246 Query: 219 --QVKKFFL 225 + + L Sbjct: 247 CVDIAEILL 255 Score = 150 bits (378), Expect = 5e-37, Method: Composition-based stats. Identities = 58/217 (26%), Positives = 88/217 (40%), Gaps = 9/217 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKD-QDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 L+ + + E KV +L + + Q+ R PLH + +I L+ N+ Sbjct: 71 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANI-- 128 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D + TP A +LE VK L D +G TCLHLA K +EV Q Sbjct: 129 -DTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK--DAEGSTCLHLAAKKGHYEVVQ 185 Query: 125 FLIENGA-SVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALA 183 +L+ NG V +D P+ A + L++LL G S +N +D + L A Sbjct: 186 YLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKG-SDINIRDNEENICLHWAAF 244 Query: 184 EGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQV 220 G D A +L+ + V+ G +A E Sbjct: 245 SGCVDIAEILL-AAKCDLHAVNIHGDSPLHIAARENR 280 Score = 130 bits (326), Expect = 6e-31, Method: Composition-based stats. Identities = 50/184 (27%), Positives = 81/184 (44%), Gaps = 8/184 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME-NVN 63 PL +A N V+ L+ + L+ KD +G LH + +E+ +LLS + +VN Sbjct: 138 PLMEAAENNHLEAVKYLIKAGA-LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVN 196 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 DD GWTP A ++++VK L + D+N N+ CLH A +++ Sbjct: 197 C---QDDGGWTPMIWATEYKHVDLVKLLLSKGS--DINIRDNEENICLHWAAFSGCVDIA 251 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALA 183 + L+ + + PLH AA + +L S V ++K+G TPL A Sbjct: 252 EILLAAKCDLHAVNIHGDSPLHIAARENRYDCV-VLFLSRDSDVTLKNKEGETPLQCASL 310 Query: 184 EGHG 187 Sbjct: 311 NSQV 314 >5H76-A nrPDB Length = 201 Score = 164 bits (416), Expect = 2e-41, Method: Composition-based stats. Identities = 52/158 (32%), Positives = 77/158 (48%), Gaps = 8/158 (5%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRP 95 GR L + + L++ +VN D++G TP H+A G+LE+V+ L Sbjct: 7 GRKLLE-AARAGQDDEVRILMANGADVNA---ADNTGTTPLHLAAYSGHLEIVEVLLKHG 62 Query: 96 LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKL 155 D++ G T LHLA E+ + L++NGA V D PLH AA G L++ Sbjct: 63 --ADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEI 120 Query: 156 IELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 +E+L G VN QDK G T ++ G+ D A +L Sbjct: 121 VEVLLKHGA--VNAQDKFGKTAFDISIDNGNEDLAQIL 156 Score = 150 bits (378), Expect = 6e-37, Method: Composition-based stats. Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 8/152 (5%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 A G + V+ L D+N N G T LHLA E+ + L+++GA V Sbjct: 10 LLEAARAGQDDEVRILMANG--ADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDA 67 Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVE 195 D F PLH AA G L+++E+L G + VN D G TPL A G+ + +L+ Sbjct: 68 SDVFGYTPLHLAAYWGHLEIVEVLLKNG-ADVNAMDSDGMTPLHLAAKWGYLEIVEVLL- 125 Query: 196 KYGAEYDLVDNKGAKAEDVAL---NEQVKKFF 224 K+GA + D G A D+++ NE + + Sbjct: 126 KHGA-VNAQDKFGKTAFDISIDNGNEDLAQIL 156 Score = 140 bits (352), Expect = 6e-34, Method: Composition-based stats. Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 7/191 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ L+ + + D G PLH + EI LL +V Sbjct: 10 LLEAARAGQDDEVRILMANGADVN-AADNTGTTPLHLAAYSGHLEIVEVLLKHGADV--- 65 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D D G+TP H+A G+LE+V+ L D+N + + G+T LHLA + E+ + Sbjct: 66 DASDVFGYTPLHLAAYWGHLEIVEVLLKNG--ADVNAMDSDGMTPLHLAAKWGYLEIVEV 123 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEG 185 L+++GA V +DKF + + G+ L ++L + +++ +L + Sbjct: 124 LLKHGA-VNAQDKFGKTAFDISIDNGNEDLAQILAFYEILHLPNLNEEQRNAFIQSLKDD 182 Query: 186 HGDAAVLLVEK 196 +A LL E Sbjct: 183 PSQSANLLAEA 193 Score = 104 bits (259), Expect = 3e-23, Method: Composition-based stats. Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 7/122 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A V+ LL + D G PLH + + EI LL +VN Sbjct: 42 PLHLAAYSGHLEIVEVLLKHGADV-DASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNA 100 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D G TP H+A G LE+V+ L +N G T +++ +++Q Sbjct: 101 M---DSDGMTPLHLAAKWGYLEIVEVLLKHGA---VNAQDKFGKTAFDISIDNGNEDLAQ 154 Query: 125 FL 126 L Sbjct: 155 IL 156 Score = 68.9 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 25/84 (29%), Positives = 38/84 (45%), Gaps = 5/84 (5%) Query: 147 AASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDN 206 AA G + +L G + VN D G TPL A GH + +L+ K+GA+ D D Sbjct: 13 AARAGQDDEVRILMANG-ADVNAADNTGTTPLHLAAYSGHLEIVEVLL-KHGADVDASDV 70 Query: 207 KGAKAEDVAL---NEQVKKFFLNN 227 G +A + ++ + L N Sbjct: 71 FGYTPLHLAAYWGHLEIVEVLLKN 94 >6FES-A nrPDB Length = 367 Score = 163 bits (412), Expect = 7e-41, Method: Composition-based stats. Identities = 49/153 (32%), Positives = 72/153 (47%), Gaps = 6/153 (3%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + LL+ +VN D++G+TP H+A G+L +V+ L D Sbjct: 10 LLEAARAGQDDEVRILLANGADVN---TADETGFTPLHLAAWEGHLGIVEVLLKNG--AD 64 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 +N +G T LHLA E+ + L++NGA V D PLH AA G +++E+L Sbjct: 65 VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVL 124 Query: 160 CGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVL 192 G + QDK G TP A G+ A L Sbjct: 125 LKNG-ADARAQDKFGKTPEDLARDNGYESVARL 156 Score = 160 bits (404), Expect = 5e-40, Method: Composition-based stats. Identities = 46/139 (33%), Positives = 66/139 (47%), Gaps = 4/139 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N G T LHLA + + + L++NGA V D+ Sbjct: 13 AARAGQDDEVRILLANG--ADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDE 70 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 PLH AA G L+++E+L G + VN D G PL A GH + +L+ K G Sbjct: 71 RGHTPLHLAAYTGHLEIVEVLLKNG-AGVNATDVIGTAPLHLAAMWGHEEIVEVLL-KNG 128 Query: 199 AEYDLVDNKGAKAEDVALN 217 A+ D G ED+A + Sbjct: 129 ADARAQDKFGKTPEDLARD 147 Score = 153 bits (387), Expect = 5e-38, Method: Composition-based stats. Identities = 45/153 (29%), Positives = 68/153 (44%), Gaps = 6/153 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ LL + + D+ G PLH + I LL +VN + Sbjct: 10 LLEAARAGQDDEVRILLANGADVNTA-DETGFTPLHLAAWEGHLGIVEVLLKNGADVNAN 68 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D+ G TP H+A G+LE+V+ L +N G LHLA E+ + Sbjct: 69 ---DERGHTPLHLAAYTGHLEIVEVLLKNGAG--VNATDVIGTAPLHLAAMWGHEEIVEV 123 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIEL 158 L++NGA R +DKF + P A G + L Sbjct: 124 LLKNGADARAQDKFGKTPEDLARDNGYESVARL 156 Score = 112 bits (280), Expect = 1e-25, Method: Composition-based stats. Identities = 38/120 (31%), Positives = 57/120 (47%), Gaps = 5/120 (4%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 L A + + L+ NGA V D+ PLH AA G L ++E+L G + VN Sbjct: 10 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNG-ADVNAN 68 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL---NEQVKKFFLNN 227 D++G TPL A GH + +L+ K GA + D G +A +E++ + L N Sbjct: 69 DERGHTPLHLAAYTGHLEIVEVLL-KNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKN 127 Score = 105 bits (263), Expect = 1e-23, Method: Composition-based stats. Identities = 34/121 (28%), Positives = 46/121 (38%), Gaps = 6/121 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A E V+ LL + + D+ G PLH + EI LL VN Sbjct: 42 PLHLAAWEGHLGIVEVLLKNGADVNAN-DERGHTPLHLAAYTGHLEIVEVLLKNGAGVNA 100 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D G P H+A G+ E+V+ L D G T LA + V++ Sbjct: 101 TDVI---GTAPLHLAAMWGHEEIVEVLLKNG--ADARAQDKFGKTPEDLARDNGYESVAR 155 Query: 125 F 125 Sbjct: 156 L 156 >5ET1-A nrPDB Length = 353 Score = 162 bits (411), Expect = 8e-41, Method: Composition-based stats. Identities = 53/211 (25%), Positives = 89/211 (42%), Gaps = 4/211 (1%) Query: 8 QACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDY 67 QA + ++ L + +D +P+H + +L+ ++ + Sbjct: 9 QAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVEEVALPAVS-- 66 Query: 68 PDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLI 127 +G TP H A + G L ++ L + + + N G T LHLA +V ++L+ Sbjct: 67 RARNGATPAHDAAATGYLSCLQWLLTQG-GCRVQEKDNSGATVLHLAARFGHPDVVKWLL 125 Query: 128 -ENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGH 186 + GA+ I +P+H AA+ G L ++LL G VN Q G TPL+ A EGH Sbjct: 126 YQGGANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGH 185 Query: 187 GDAAVLLVEKYGAEYDLVDNKGAKAEDVALN 217 + LV++ A+ L G A Sbjct: 186 LEVTKYLVQECSADPHLRAQDGMTPLHAAAQ 216 Score = 154 bits (389), Expect = 3e-38, Method: Composition-based stats. Identities = 59/218 (27%), Positives = 92/218 (42%), Gaps = 7/218 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 P H A +Q LL + +KD G LH + F ++ +LL + Sbjct: 74 PAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQGG--AN 131 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D+G P H A + G+L +K L +N TN G T L+LA + EV++ Sbjct: 132 SAITTDTGALPIHYAAAKGDLPSLKLLVGH-YPEGVNAQTNNGATPLYLACQEGHLEVTK 190 Query: 125 FLI-ENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALA 183 +L+ E A ++ + PLH AA +G ++ L + + QD G T + A + Sbjct: 191 YLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAAS 250 Query: 184 EGHGDAAVLLVEKYGAEYDLVDNKGAKAE-DVALNEQV 220 GH L+ +GAE D G D A N ++ Sbjct: 251 RGHTKVLSWLLL-HGAEI-SQDLWGGTPLHDAAENGEL 286 Score = 136 bits (343), Expect = 7e-33, Method: Composition-based stats. Identities = 49/225 (21%), Positives = 87/225 (38%), Gaps = 4/225 (1%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 + P+H A + ++ L+ + + ++G P H + + +LL++ Sbjct: 36 LDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGG 95 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 D+SG T H+A G+ +VVK L + + T+ G +H A K Sbjct: 96 --CRVQEKDNSGATVLHLAARFGHPDVVKWLLYQG-GANSAITTDTGALPIHYAAAKGDL 152 Query: 121 EVSQFLIEN-GASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLF 179 + L+ + V + PL+ A G L++ + L + + + + G TPL Sbjct: 153 PSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLH 212 Query: 180 HALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 A GH V LV + D+ GA A A + K Sbjct: 213 AAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVL 257 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 45/190 (23%), Positives = 86/190 (45%), Gaps = 7/190 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSK-MENVN 63 P+H A + + ++ L+ P + + +G PL+ + E+T +L+ + + + Sbjct: 142 PIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPH 201 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 L G TP H A +G+ V+ L ++ + G T +H A + +V Sbjct: 202 LRAQD---GMTPLHAAAQMGHNPVLVWLVSF-ADVSFSEQDHDGATAMHFAASRGHTKVL 257 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALA 183 +L+ +GA + +D + PLH AA G L+ ++L G + ++ +D G+T A Sbjct: 258 SWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQILAVNG-AGLDVRDHDGYTAADLAEF 315 Query: 184 EGHGDAAVLL 193 GH + L Sbjct: 316 NGHTHCSRYL 325 >3B7B-A nrPDB Length = 237 Score = 162 bits (409), Expect = 1e-40, Method: Composition-based stats. Identities = 53/211 (25%), Positives = 87/211 (41%), Gaps = 7/211 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A L+ + + + +D R PL + E +L+ V Sbjct: 14 PLHAAAEAGHVDICHMLVQAGAN-IDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALV-- 70 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 D D G T H+A G+ EVV+ L D+N + G T + A K ++ + Sbjct: 71 -DPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM-DVNCQDDGGWTPMIWATEYKHVDLVK 128 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 L+ G+ + I+D I LH AA G + + E+L K ++ + G +PL A E Sbjct: 129 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA-AKCDLHAVNIHGDSPLHIAARE 187 Query: 185 GHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 D VL + + ++ L + +G A Sbjct: 188 NRYDCVVLFLSRD-SDVTLKNKEGETPLQCA 217 Score = 151 bits (382), Expect = 2e-37, Method: Composition-based stats. Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 3/146 (2%) Query: 70 DSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIEN 129 + +P H A G++++ L +++ + T L A E ++LI+ Sbjct: 9 QNKRSPLHAAAEAGHVDICHMLVQAG--ANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 66 Query: 130 GASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDA 189 GA V KD LH AA G ++++ L G+ VN QD GWTP+ A H D Sbjct: 67 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 126 Query: 190 AVLLVEKYGAEYDLVDNKGAKAEDVA 215 LL+ K G++ ++ DN+ A Sbjct: 127 VKLLLSK-GSDINIRDNEENICLHWA 151 Score = 135 bits (340), Expect = 1e-32, Method: Composition-based stats. Identities = 53/191 (27%), Positives = 78/191 (40%), Gaps = 8/191 (4%) Query: 31 QKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKS 90 + Q+ R PLH + +I L+ N+ D + TP A +LE VK Sbjct: 6 MEHQNKRSPLHAAAEAGHVDICHMLVQAGANI---DTCSEDQRTPLMEAAENNHLEAVKY 62 Query: 91 LYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGA-SVRIKDKFNQIPLHRAAS 149 L D +G TCLHLA K +EV Q+L+ NG V +D P+ A Sbjct: 63 LIKAGALVDPK--DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATE 120 Query: 150 VGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGA 209 + L++LL G S +N +D + L A G D A +L+ + V+ G Sbjct: 121 YKHVDLVKLLLSKG-SDINIRDNEENICLHWAAFSGCVDIAEILL-AAKCDLHAVNIHGD 178 Query: 210 KAEDVALNEQV 220 +A E Sbjct: 179 SPLHIAARENR 189 Score = 125 bits (315), Expect = 1e-29, Method: Composition-based stats. Identities = 50/184 (27%), Positives = 81/184 (44%), Gaps = 8/184 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME-NVN 63 PL +A N V+ L+ + L+ KD +G LH + +E+ +LLS + +VN Sbjct: 47 PLMEAAENNHLEAVKYLIKAGA-LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVN 105 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 DD GWTP A ++++VK L + D+N N+ CLH A +++ Sbjct: 106 C---QDDGGWTPMIWATEYKHVDLVKLLLSKGS--DINIRDNEENICLHWAAFSGCVDIA 160 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALA 183 + L+ + + PLH AA + +L S V ++K+G TPL A Sbjct: 161 EILLAAKCDLHAVNIHGDSPLHIAARENRYDCV-VLFLSRDSDVTLKNKEGETPLQCASL 219 Query: 184 EGHG 187 Sbjct: 220 NSQV 223 >3LJN-A nrPDB Length = 364 Score = 162 bits (409), Expect = 1e-40, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 107/240 (44%), Gaps = 32/240 (13%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 +H A + + +V+ L+ + S +Q ++ G LH + F + +L S E +L Sbjct: 24 IHVAARKGQTDEVRRLIETGVSPTIQ-NRFGCTALHLACKFGCVDTAKYLASVGEVHSLW 82 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYD----RPLKPD--LNKITNQ------------- 106 G P H+A ++V +L + R P+ LN+ + Sbjct: 83 -----HGQKPIHLAVMANKTDLVVALVEGAKERGQMPESLLNECDEREVNEIGSHVKHCK 137 Query: 107 GVTCLH--LAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGK 164 G T LH + +G ++ E+ + L++ GAS KDK ++ PL RA + + ++L+ Sbjct: 138 GQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKADETPLMRAMEFRNREALDLMMDTVP 197 Query: 165 SA----VNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQV 220 S +++ +KQG + L A+ D A+ VE G + ++ DN+ +++ + Sbjct: 198 SKSSLRLDYANKQGNSHLHWAILINWEDVAMRFVE-MGIDVNMEDNEHTVPLYLSVRAAM 256 Score = 70.5 bits (171), Expect = 5e-13, Method: Composition-based stats. Identities = 38/190 (20%), Positives = 63/190 (33%), Gaps = 30/190 (15%) Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 DD H+A G + V+ L + + P + G T LHLA + + Sbjct: 12 NRIKSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQ--NRFGCTALHLACKFGCVDTA 69 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG-------KSAVNWQDKQ--- 173 ++L G V Q P+H A L+ L +S +N D++ Sbjct: 70 KYLASVGE-VH-SLWHGQKPIHLAVMANKTDLVVALVEGAKERGQMPESLLNECDEREVN 127 Query: 174 ----------GWTPLFHALAEG--HGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL---NE 218 G T L + G + + +LV+ GA D A+ N Sbjct: 128 EIGSHVKHCKGQTALHWCVGLGPEYLEMIKILVQ-LGASPTAKDKADETPLMRAMEFRNR 186 Query: 219 QVKKFFLNNV 228 + ++ V Sbjct: 187 EALDLMMDTV 196 Score = 64.3 bits (155), Expect = 4e-11, Method: Composition-based stats. Identities = 42/181 (23%), Positives = 68/181 (37%), Gaps = 28/181 (15%) Query: 5 PLHQACMENEFFKVQELLHSKP-------SLLLQKDQ-------------DGRIPLHWSV 44 P+H A M N+ V L+ SLL + D+ G+ LHW V Sbjct: 87 PIHLAVMANKTDLVVALVEGAKERGQMPESLLNECDEREVNEIGSHVKHCKGQTALHWCV 146 Query: 45 SFQ--AHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYD---RPLKPD 99 E+ L+ + D D+ TP A N E + + D Sbjct: 147 GLGPEYLEMIKILVQLGASPTAKDKADE---TPLMRAMEFRNREALDLMMDTVPSKSSLR 203 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 L+ QG + LH A+ W +V+ +E G V ++D + +PL+ + + L + L Sbjct: 204 LDYANKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTVPLYLSVRAAMVLLTKEL 263 Query: 160 C 160 Sbjct: 264 L 264 Score = 27.7 bits (60), Expect = 4.5, Method: Composition-based stats. Identities = 20/108 (18%), Positives = 36/108 (33%), Gaps = 10/108 (9%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 LH A + N + + +D + +PL+ SV +T LL K + + Sbjct: 215 LHWAILINWEDVAMRFVEMGIDVN-MEDNEHTVPLYLSVRAAMVLLTKELLQKTDVFLIQ 273 Query: 66 DYPDDSGWTPFHI---------ACSVGNLEVVKSLYDRPLKPDLNKIT 104 P +G T A + + + V L L + + Sbjct: 274 ACPYHNGTTVLPDRVVWLDFVPAAADPSKQEVLQLLQEKLDEVVRSLN 321 >6AUN-A nrPDB Length = 752 Score = 154 bits (388), Expect = 4e-38, Method: Composition-based stats. Identities = 46/181 (25%), Positives = 77/181 (42%), Gaps = 9/181 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH AC + V+ LL + P+H ++ F ++S M++ + Sbjct: 223 PLHLACQMGKQEMVRVLLLCNARCNVM--GPSGFPIHTAMKFSQKGCAEMIIS-MDSSQI 279 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 G +P H A N E+ + L R D++ + G T LH+AV + F+ Sbjct: 280 HSKDPRYGASPLHWA---KNAEMARMLLKRG--CDVDSTSAAGNTALHVAVMRNRFDCVM 334 Query: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 L+ GA+ + PLH A S ++++I+ L G + V+ + G TP F A Sbjct: 335 VLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFG-AEVDTPNDFGETPAFMASKI 393 Query: 185 G 185 Sbjct: 394 S 394 Score = 128 bits (322), Expect = 2e-30, Method: Composition-based stats. Identities = 45/209 (21%), Positives = 81/209 (38%), Gaps = 10/209 (4%) Query: 20 ELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIA 79 E+L L+ + H +V E + ++ G TP H+A Sbjct: 105 EVLQHLSDLI--RSHPSWTVTHLAVELGIRECFHH---SRIISCANSTENEEGCTPLHLA 159 Query: 80 CSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG-ASVRIKDK 138 C G+ E++ L ++ N+G T H AV +V Q L +N A + +K Sbjct: 160 CRKGDSEILVELVQY-CHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVNK 218 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 PLH A +G +++ +L L + N G+ P+ A+ A +++ Sbjct: 219 QGLTPLHLACQMGKQEMVRVLL-LCNARCNVMGPSGF-PIHTAMKFSQKGCAEMIISMDS 276 Query: 199 AEYDLVDNK-GAKAEDVALNEQVKKFFLN 226 ++ D + GA A N ++ + L Sbjct: 277 SQIHSKDPRYGASPLHWAKNAEMARMLLK 305 Score = 127 bits (319), Expect = 4e-30, Method: Composition-based stats. Identities = 52/214 (24%), Positives = 85/214 (39%), Gaps = 16/214 (7%) Query: 7 HQACMENEFFKVQELLHSK---PSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVN 63 H A ++E H ++++G PLH + EI L+ Sbjct: 124 HLAVELG----IRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQY--CHA 177 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 D D+ G T FH A G+ V L + LN++ QG+T LHLA E+ Sbjct: 178 QMDVTDNKGETAFHYAV-QGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMV 236 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQD-KQGWTPLFHAL 182 + L+ A + P+H A E++ + S ++ +D + G +PL A Sbjct: 237 RVLLLCNARCNVMGPSGF-PIHTAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWA- 294 Query: 183 AEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL 216 + + A +L+ K G + D G A VA+ Sbjct: 295 --KNAEMARMLL-KRGCDVDSTSAAGNTALHVAV 325 >5HKP-A nrPDB Length = 351 Score = 152 bits (383), Expect = 1e-37, Method: Composition-based stats. Identities = 48/146 (32%), Positives = 74/146 (50%), Gaps = 3/146 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A GN E + +L PL + + + T LHLA G + Q L+++GA V KDK Sbjct: 31 AARSGNEEKLMALLT-PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDK 89 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 +PLH A S G ++ ELL G + VN D +TPL A ++ + LL+ +G Sbjct: 90 GGLVPLHNACSYGHYEVTELLLKHG-ACVNAMDLWQFTPLHEAASKNRVEVCSLLLS-HG 147 Query: 199 AEYDLVDNKGAKAEDVALNEQVKKFF 224 A+ LV+ G A D+A ++++ Sbjct: 148 ADPTLVNCHGKSAVDMAPTPELRERL 173 Score = 143 bits (360), Expect = 6e-35, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 100/275 (36%), Gaps = 62/275 (22%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N VQ LL + KD+ G +PLH + S+ +E+T LL VN Sbjct: 61 PLHLAAGYNRVRIVQLLLQHGADVH-AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 119 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGV-----TC--------- 110 D +TP H A S +EV L P L + T Sbjct: 120 MDL---WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 176 Query: 111 --------------------------------------LHLAVGKKWF---EVSQFLIEN 129 LH AV +V++ L+ Sbjct: 177 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRK 236 Query: 130 GASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDA 189 GA+V K+K PLH AA ++E+L G + +N D G T L A GH Sbjct: 237 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG-AKMNALDSLGQTALHRAALAGHLQT 295 Query: 190 AVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 LL+ YG++ ++ +G A + NE V++ Sbjct: 296 CRLLLS-YGSDPSIISLQGFTAAQMG-NEAVQQIL 328 Score = 117 bits (294), Expect = 3e-27, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 80/233 (34%), Gaps = 29/233 (12%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A K+ LL D PLH + + I LL +V+ Sbjct: 28 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA- 86 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D G P H ACS G+ EV + L +N + T LH A K EV Sbjct: 87 --KDKGGLVPLHNACSYGHYEVTELLLKHGAC--VNAMDLWQFTPLHEAASKNRVEVCSL 142 Query: 126 LIENGASVRIKDKFNQIPLHRAAS-----------VGS--------LKLIELLCGLGKSA 166 L+ +GA + + + + A + G L ++ L Sbjct: 143 LLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI 202 Query: 167 VNW-QDKQGWTPLFHALAEGHG---DAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 +N+ Q + T L A+A H A LL+ K GA + + VA Sbjct: 203 INFKQPQSHETALHCAVASLHPKRKQVAELLLRK-GANVNEKNKDFMTPLHVA 254 Score = 104 bits (260), Expect = 3e-23, Method: Composition-based stats. Identities = 57/266 (21%), Positives = 89/266 (33%), Gaps = 65/266 (24%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH AC + + LL + D PLH + S E+ S LLS + L Sbjct: 94 PLHNACSYGHYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 152 Query: 65 DD---------------------------------------------------YPDDSGW 73 + S Sbjct: 153 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 212 Query: 74 TPFHIACSVGNL---EVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG 130 T H A + + +V + L + ++N+ +T LH+A + +V + L ++G Sbjct: 213 TALHCAVASLHPKRKQVAELLLRKG--ANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 270 Query: 131 ASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAA 190 A + D Q LHRAA G L+ LL G S + QG+T A G+ Sbjct: 271 AKMNALDSLGQTALHRAALAGHLQTCRLLLSYG-SDPSIISLQGFT----AAQMGNEAVQ 325 Query: 191 VLLVE---KYGAEYDLVDNKGAKAED 213 +L E ++ D + +KA D Sbjct: 326 QILSESTPMRTSDVDYRLLEASKAGD 351 Score = 55.4 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 37/104 (35%), Gaps = 8/104 (7%) Query: 131 ASVRIK----DKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGH 186 A K ++ + L AA G+ + + L + D + TPL A Sbjct: 11 ADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR 70 Query: 187 GDAAVLLVEKYGAEYDLVDNKGAKAEDVALN---EQVKKFFLNN 227 LL++ +GA+ D G A + +V + L + Sbjct: 71 VRIVQLLLQ-HGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 113 >5GP7-A nrPDB Length = 169 Score = 144 bits (364), Expect = 2e-35, Method: Composition-based stats. Identities = 48/156 (30%), Positives = 74/156 (47%), Gaps = 3/156 (1%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG 130 G A G L V+ L P + + T LHLA G EV+++L+E+G Sbjct: 8 RGDAALLDAAKKGCLARVQKLCT-PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 66 Query: 131 ASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAA 190 A V +DK IPLH AAS G + + LL + VN DK +TPL A +G Sbjct: 67 ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN-TCVNATDKWAFTPLHEAAQKGRTQLC 125 Query: 191 VLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLN 226 LL+ +GA+ + + +G D+A + ++ ++ Sbjct: 126 ALLL-AHGADPTMKNQEGQTPLDLATADDIRALLID 160 Score = 119 bits (299), Expect = 8e-28, Method: Composition-based stats. Identities = 41/164 (25%), Positives = 66/164 (40%), Gaps = 12/164 (7%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGR--IPLHWSVSFQAHEITSFLLSKMENVN 63 L A + +VQ+L P + +D GR PLH + + E+ +LL +VN Sbjct: 13 LLDAAKKGCLARVQKLCT--PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 70 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 D G P H A S G++++ L +N T LH A K ++ Sbjct: 71 A---QDKGGLIPLHNAASYGHVDIAALLIKY--NTCVNATDKWAFTPLHEAAQKGRTQLC 125 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAV 167 L+ +GA +K++ Q PL A + + LL + Sbjct: 126 ALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDAMPENL 166 Score = 90.1 bits (222), Expect = 7e-19, Method: Composition-based stats. Identities = 32/110 (29%), Positives = 45/110 (40%), Gaps = 6/110 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N + LL + Q D+ G IPLH + S+ +I + L+ VN Sbjct: 46 PLHLAAGYNNLEVAEYLLEHGADVNAQ-DKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 104 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLA 114 D +TP H A G ++ L P + +G T L LA Sbjct: 105 T---DKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK--NQEGQTPLDLA 149 Score = 56.2 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 36/97 (37%), Gaps = 8/97 (8%) Query: 4 YPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVN 63 PLH A L+ + D+ PLH + ++ + LL+ + Sbjct: 78 IPLHNAASYGHVDIAALLIKYNTCVN-ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 136 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDL 100 + + G TP +A + + +++L + +L Sbjct: 137 M---KNQEGQTPLDLATA----DDIRALLIDAMPENL 166 >4Z68-A nrPDB Length = 155 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 45/141 (31%), Positives = 68/141 (48%), Gaps = 3/141 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G++E VK L + I + T LH A G V ++L+++GA V KDK Sbjct: 10 AAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 68 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 +PLH A S G ++ ELL G + VN D +TPL A A+G + LL++ +G Sbjct: 69 GGLVPLHNACSYGHYEVAELLVKHG-AVVNVADLWKFTPLHEAAAKGKYEICKLLLQ-HG 126 Query: 199 AEYDLVDNKGAKAEDVALNEQ 219 A+ + G D+ + Sbjct: 127 ADPTKKNRDGNTPLDLVKDGD 147 Score = 119 bits (298), Expect = 9e-28, Method: Composition-based stats. Identities = 40/156 (25%), Positives = 67/156 (42%), Gaps = 10/156 (6%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGR--IPLHWSVSFQAHEITSFLLSKMENVN 63 L +A + V++L + +D +GR PLH++ + + +LL +V+ Sbjct: 7 LLEAAKAGDVETVKKLCT--VQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVH 64 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 D G P H ACS G+ EV + L +N T LH A K +E+ Sbjct: 65 A---KDKGGLVPLHNACSYGHYEVAELLVKHGAV--VNVADLWKFTPLHEAAAKGKYEIC 119 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 + L+++GA K++ PL G + +LL Sbjct: 120 KLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLL 154 Score = 99.7 bits (247), Expect = 8e-22, Method: Composition-based stats. Identities = 33/107 (30%), Positives = 46/107 (42%), Gaps = 6/107 (5%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PLH A N V+ LL + KD+ G +PLH + S+ +E+ L+ VN+ Sbjct: 40 PLHFAAGYNRVSVVEYLLQHGADVH-AKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 98 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCL 111 D +TP H A + G E+ K L P K G T L Sbjct: 99 ADL---WKFTPLHEAAAKGKYEICKLLLQHGADP--TKKNRDGNTPL 140 >4OT9-A nrPDB Length = 359 Score = 135 bits (340), Expect = 1e-32, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 100/264 (37%), Gaps = 44/264 (16%) Query: 3 NYPLHQACMENEFFKVQELL-----HSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLS 57 + PLH A + + +++++ ++ + + PLH +V + SFLL Sbjct: 83 DTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLR 142 Query: 58 KMENVNLDDYPDDSGWTPFHIA--CSVGNLEVVKSLYDRPLKPDLNKI---TNQGVTCLH 112 + L D G + H+A G E++++L + +G+ +H Sbjct: 143 VGADPAL---LDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVH 199 Query: 113 LAVGKKWFEVSQFLIENGASVRIKD-KFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQD 171 LAV + E L+++GA V + + + LH A + L L+ L ++ VN + Sbjct: 200 LAVRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNART 259 Query: 172 KQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDN------------------------- 206 G TPL A G+ LL+ K GA+ + Sbjct: 260 FAGNTPLHLAAGLGYPTLTRLLL-KAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDT 318 Query: 207 ----KGAKAEDVALNEQVKKFFLN 226 +G D+ + +VK LN Sbjct: 319 RSSFRGHTPLDLTCSTKVKTLLLN 342 Score = 123 bits (308), Expect = 8e-29, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 85/228 (37%), Gaps = 15/228 (6%) Query: 12 ENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITS---FLLSKMENVNLDDYP 68 + LL + LL +D++G PLH ++ + +++ +++ + + Sbjct: 58 YGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLT 117 Query: 69 DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLA--VGKKWFEVSQFL 126 + TP H+A G VV L P L + G + +HLA G E+ + L Sbjct: 118 NHLHQTPLHLAVITGQTSVVSFLLRVGADPAL--LDRHGDSAMHLALRAGAGAPELLRAL 175 Query: 127 IENGAS-----VRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHA 181 +++GA + + D P+H A S + ++LL G + + G T L A Sbjct: 176 LQSGAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGGRTALHLA 235 Query: 182 LAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALN---EQVKKFFLN 226 LV K A + G +A + + L Sbjct: 236 TEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLK 283 Score = 36.6 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 25/73 (34%), Gaps = 5/73 (6%) Query: 149 SVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVE--KYGAE---YDL 203 G L + + QD+ G TPL A+ G +V + + +L Sbjct: 57 DYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNL 116 Query: 204 VDNKGAKAEDVAL 216 ++ +A+ Sbjct: 117 TNHLHQTPLHLAV 129 >5CBO-A nrPDB Length = 176 Score = 134 bits (338), Expect = 2e-32, Method: Composition-based stats. Identities = 42/117 (35%), Positives = 59/117 (50%), Gaps = 3/117 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A G + V+ L D+N + N GVT LHLA FE+ + L++ GA V D Sbjct: 10 AAHAGQDDEVRILMANG--ADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDA 67 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVE 195 PLH AA G L ++E+L G + VN QDK G T ++ G+ D A +L + Sbjct: 68 TGDTPLHLAAKWGYLGIVEVLLKYG-ADVNAQDKFGKTAFDISIDNGNEDLAEILCK 123 Score = 126 bits (317), Expect = 6e-30, Method: Composition-based stats. Identities = 39/120 (32%), Positives = 57/120 (47%), Gaps = 5/120 (4%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 L A + + L+ NGA V D F PLH AA G +++E+L G + VN Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYG-ADVNAS 65 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVAL---NEQVKKFFLNN 227 D G TPL A G+ +L+ KYGA+ + D G A D+++ NE + + N Sbjct: 66 DATGDTPLHLAAKWGYLGIVEVLL-KYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKN 124 Score = 120 bits (300), Expect = 6e-28, Method: Composition-based stats. Identities = 34/125 (27%), Positives = 55/125 (44%), Gaps = 5/125 (4%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + L++ +VN D+ G TP H+A G+ E+V+ L D Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAM---DNFGVTPLHLAAYWGHFEIVEVLLKYG--AD 61 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 +N G T LHLA + + + L++ GA V +DKF + + G+ L E+L Sbjct: 62 VNASDATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEIL 121 Query: 160 CGLGK 164 C Sbjct: 122 CKNKA 126 Score = 102 bits (254), Expect = 1e-22, Method: Composition-based stats. Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 6/126 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L +A + +V+ L+ + + D G PLH + + EI LL +VN Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAM-DNFGVTPLHLAAYWGHFEIVEVLLKYGADVNAS 65 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D +G TP H+A G L +V+ L D+N G T +++ ++++ Sbjct: 66 ---DATGDTPLHLAAKWGYLGIVEVLLKYG--ADVNAQDKFGKTAFDISIDNGNEDLAEI 120 Query: 126 LIENGA 131 L +N A Sbjct: 121 LCKNKA 126 >3ZKJ-A nrPDB Length = 261 Score = 128 bits (321), Expect = 3e-30, Method: Composition-based stats. Identities = 46/219 (21%), Positives = 81/219 (36%), Gaps = 11/219 (5%) Query: 1 MSNY-PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKM 59 MS++ P+H+A + ++ L+ ++ + D PLH + LL Sbjct: 1 MSDWSPMHEAAIHGHQLSLRNLISQGWAVNI-ITADHVSPLHEACLGGHLSCVKILLKHG 59 Query: 60 ENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKW 119 VN TP AC G+ + V L + + +H A + Sbjct: 60 AQVNGVTADW---HTPLFNACVSGSWDCVNLLLQHGASVQP---ESDLASPIHEAARRGH 113 Query: 120 FEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLF 179 E LI G ++ K PL+ A ++ L G + VN Q K +PL Sbjct: 114 VECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESG-ADVN-QGKGQDSPLH 171 Query: 180 HALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNE 218 A+A + L+ +GA+ + +G + ++ E Sbjct: 172 -AVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPE 209 Score = 100 bits (248), Expect = 6e-22, Method: Composition-based stats. Identities = 37/150 (24%), Positives = 57/150 (38%), Gaps = 5/150 (3%) Query: 73 WTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGAS 132 W+P H A G+ +++L + +N IT V+ LH A + L+++GA Sbjct: 4 WSPMHEAAIHGHQLSLRNLISQGWA--VNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 61 Query: 133 VRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVL 192 V PL A GS + LL G S D +P+ A GH + Sbjct: 62 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDL--ASPIHEAARRGHVECVNS 119 Query: 193 LVEKYGAEYDLVDNKGAKAEDVALNEQVKK 222 L+ YG D + +A Q + Sbjct: 120 LI-AYGGNIDHKISHLGTPLYLACENQQRA 148 >5D68-A nrPDB Length = 486 Score = 110 bits (276), Expect = 3e-25, Method: Composition-based stats. Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 5/113 (4%) Query: 38 IPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 PLH S E+ S LLS+ +VN D W P H AC G +E + L ++ K Sbjct: 40 FPLHRSACEGDSELLSRLLSERFSVN---QLDSDHWAPIHYACWYGKVEATRILLEKG-K 95 Query: 98 PDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGA-SVRIKDKFNQIPLHRAAS 149 + N + Q + LH A G E+ Q L+ + I D+ + PL+ Sbjct: 96 CNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEE 148 Score = 97.0 bits (240), Expect = 6e-21, Method: Composition-based stats. Identities = 40/166 (24%), Positives = 74/166 (44%), Gaps = 14/166 (8%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 + ++PLH++ E + + LL + S+ Q D D P+H++ + E T LL K + Sbjct: 37 VDDFPLHRSACEGDSELLSRLLSERFSVN-QLDSDHWAPIHYACWYGKVEATRILLEKGK 95 Query: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLA---VGK 117 + + +P H A G+ E+V+ L + P D + QG + L++ Sbjct: 96 --CNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPET-DRHITDQQGRSPLNICEENKQN 152 Query: 118 KWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG 163 W E ++ L E I + ++ ++R GS + +EL G Sbjct: 153 NWEEAAKLLKEA-----INKPYEKVRIYRMD--GSYRSVELKHGNN 191 Score = 75.1 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 43/105 (40%) Query: 110 CLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNW 169 LH + + E+ L+ SV D + P+H A G ++ +L GK N Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 170 QDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDV 214 + Q +PL A GH + +L+ + + D +G ++ Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNI 145 Score = 57.4 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 44/91 (48%), Gaps = 4/91 (4%) Query: 140 NQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGA 199 + PLHR+A G +L+ L + +VN D W P+ +A G +A +L+EK Sbjct: 38 DDFPLHRSACEGDSELLSRLLSE-RFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKC 96 Query: 200 EYDLVDNKGAKAEDVAL---NEQVKKFFLNN 227 +L++ + + A + ++ + LN+ Sbjct: 97 NPNLLNGQLSSPLHFAAGGGHAEIVQILLNH 127 >1G3N-B nrPDB Length = 168 Score = 110 bits (275), Expect = 5e-25, Method: Composition-based stats. Identities = 43/160 (26%), Positives = 67/160 (41%), Gaps = 7/160 (4%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + E + LL + + G T + +GN E+ + L R PD Sbjct: 9 LASAAARGDLEQLTSLLQNNV---NVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPD 64 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 L T G +H A + + Q L+E A V I+D +PLH AA G L+++E L Sbjct: 65 LKDRT--GFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122 Query: 160 CGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGA 199 S V ++ +G T A G + L++ GA Sbjct: 123 VKHTASNVGHRNHKGDTACDLARLYGRNEVVS-LMQANGA 161 Score = 96.3 bits (238), Expect = 9e-21, Method: Composition-based stats. Identities = 38/137 (27%), Positives = 64/137 (46%), Gaps = 4/137 (2%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A + G+LE + SL + + G T L + + E+++ L+ GA+ +KD+ Sbjct: 12 AAARGDLEQLTSLLQNNVNVN--AQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDR 68 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 +H AA G L ++ L ++ VN +D +G PL A EGH LV+ Sbjct: 69 TGFAVIHDAARAGFLDTLQTLLEF-QADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127 Query: 199 AEYDLVDNKGAKAEDVA 215 + ++KG A D+A Sbjct: 128 SNVGHRNHKGDTACDLA 144 Score = 73.5 bits (179), Expect = 8e-14, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 47/119 (39%), Gaps = 5/119 (4%) Query: 13 NEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSG 72 + LL + KD+ G +H + + LL +VN++ D+ G Sbjct: 48 GNPEIARRLLLRGANP-DLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIE---DNEG 103 Query: 73 WTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGA 131 P H+A G+L VV+ L ++ ++G T LA EV + NGA Sbjct: 104 NLPLHLAAKEGHLRVVEFLVKHTAS-NVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161 Score = 52.7 bits (125), Expect = 1e-07, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 36/96 (37%), Gaps = 3/96 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 +H A +Q LL + + + +D +G +PLH + + FL+ + Sbjct: 74 IHDAARAGFLDTLQTLLEFQADVNI-EDNEGNLPLHLAAKEGHLRVVEFLVKHTAS--NV 130 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLN 101 + + G T +A G EVV + N Sbjct: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATN 166 Score = 43.9 bits (102), Expect = 5e-05, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 47/105 (44%), Gaps = 3/105 (2%) Query: 114 AVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 A + E L++N +V ++ F + L +G+ ++ L G + + +D+ Sbjct: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRG-ANPDLKDRT 69 Query: 174 GWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNE 218 G+ + A G D L+E + A+ ++ DN+G +A E Sbjct: 70 GFAVIHDAARAGFLDTLQTLLE-FQADVNIEDNEGNLPLHLAAKE 113 Score = 40.4 bits (93), Expect = 6e-04, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 23/58 (39%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 N PLH A E V+ L+ S + ++ G + + +E+ S + + Sbjct: 104 NLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161 >2KXP-C nrPDB Length = 118 Score = 103 bits (257), Expect = 7e-23, Method: Composition-based stats. Identities = 32/114 (28%), Positives = 50/114 (43%), Gaps = 2/114 (1%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 A+ + + + G V + + PLH AA G L+++E L G + +N Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKG-ADINAP 64 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 DK TPL A+ EGH LL+ K GA+ + G A + N+ +K Sbjct: 65 DKHHITPLLSAVYEGHVSCVKLLLSK-GADKTVKGPDGLTALEATDNQAIKALL 117 Score = 76.6 bits (187), Expect = 7e-15, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 41/104 (39%), Gaps = 5/104 (4%) Query: 41 HWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDL 100 W++ + ++K E+VN + G P H A G LE+++ L + D+ Sbjct: 7 MWALKNGDLDEVKDYVAKGEDVN---RTLEGGRKPLHYAADCGQLEILEFLLLKG--ADI 61 Query: 101 NKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPL 144 N +T L AV + + L+ GA +K L Sbjct: 62 NAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAL 105 Score = 69.3 bits (168), Expect = 1e-12, Method: Composition-based stats. Identities = 26/103 (25%), Positives = 42/103 (40%), Gaps = 6/103 (5%) Query: 9 ACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYP 68 A + +V++ + + + GR PLH++ EI FLL K ++N P Sbjct: 9 ALKNGDLDEVKDYVAKGEDVNRTL-EGGRKPLHYAADCGQLEILEFLLLKGADINA---P 64 Query: 69 DDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCL 111 D TP A G++ VK L + + G+T L Sbjct: 65 DKHHITPLLSAVYEGHVSCVKLLLSKGADKTVK--GPDGLTAL 105 >1BD8-A nrPDB Length = 156 Score = 102 bits (255), Expect = 1e-22, Method: Composition-based stats. Identities = 33/151 (21%), Positives = 64/151 (42%), Gaps = 7/151 (4%) Query: 43 SVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNK 102 + + + LL + + D + G T + G+ + L + P++ Sbjct: 9 AAARGDVQEVRRLLHR--ELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQD 65 Query: 103 ITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGL 162 + G + +H A + + + L+E+GA V + D +P+H A G ++ L Sbjct: 66 TS--GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA-- 121 Query: 163 GKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 +S ++ +D +G TPL AL G D +L Sbjct: 122 AESDLHRRDARGLTPLELALQRGAQDLVDIL 152 Score = 89.7 bits (221), Expect = 9e-19, Method: Composition-based stats. Identities = 41/158 (25%), Positives = 67/158 (42%), Gaps = 7/158 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L A + +V+ LLH + ++ G+ L + F + I LL + + N+ Sbjct: 6 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNV- 63 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D SG +P H A G L+ +K L + D+N G +HLAV + V F Sbjct: 64 --QDTSGTSPVHDAARTGFLDTLKVLVEHG--ADVNVPDGTGALPIHLAVQEGHTAVVSF 119 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG 163 L + + +D PL A G+ L+++L G Sbjct: 120 LAAE-SDLHRRDARGLTPLELALQRGAQDLVDILQGHM 156 Score = 53.5 bits (127), Expect = 8e-08, Method: Composition-based stats. Identities = 31/140 (22%), Positives = 53/140 (37%), Gaps = 37/140 (26%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A + G+++ V+ L R L + + G T L + + ++ L++ GAS Sbjct: 9 AAARGDVQEVRRLLHREL-VHPDALNRFGKTALQV-MMFGSTAIALELLKQGASP----- 61 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYG 198 N QD G +P+ A G D +LVE +G Sbjct: 62 -----------------------------NVQDTSGTSPVHDAARTGFLDTLKVLVE-HG 91 Query: 199 AEYDLVDNKGAKAEDVALNE 218 A+ ++ D GA +A+ E Sbjct: 92 ADVNVPDGTGALPIHLAVQE 111 Score = 38.5 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 23/55 (41%), Gaps = 2/55 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKM 59 P+H A E V L + S L ++D G PL ++ A ++ L M Sbjct: 104 PIHLAVQEGHTAVVSFL--AAESDLHRRDARGLTPLELALQRGAQDLVDILQGHM 156 >3EHQ-A nrPDB Length = 222 Score = 100 bits (250), Expect = 4e-22, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 52/119 (43%), Gaps = 4/119 (3%) Query: 39 PLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKP 98 PLH + L VN D +G T + AC G+ ++V+ L+ +P Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNG---LDKAGSTALYWACHGGHKDIVEMLFTQP-NI 131 Query: 99 DLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIE 157 +LN+ G T LH A K + ++ Q L+ GA +++ ++ A + L++ Sbjct: 132 ELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLK 190 Score = 87.0 bits (214), Expect = 7e-18, Method: Composition-based stats. Identities = 37/172 (21%), Positives = 63/172 (36%), Gaps = 12/172 (6%) Query: 53 SFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLH 112 + + + + + D D + W S G ++ + + LH Sbjct: 30 ELYIEEGDIIYITDMSDTNWWK----GTSKGRTGLI-------PSNYVAEQAESIDNPLH 78 Query: 113 LAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDK 172 A + + ++N V DK L+ A G ++E+L +N Q+K Sbjct: 79 EAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNK 138 Query: 173 QGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 G T L A +G+ D LL+ K GA DL + + A D+A N Sbjct: 139 LGDTALHAAAWKGYADIVQLLLAK-GARTDLRNIEKKLAFDMATNAACASLL 189 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 46/105 (43%), Gaps = 5/105 (4%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 + PLH+A ++E L ++ + D+ G L+W+ +I L ++ Sbjct: 74 DNPLHEAAKRGNLSWLRECLDNRVGVNG-LDKAGSTALYWACHGGHKDIVEMLFTQ---P 129 Query: 63 NLD-DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ 106 N++ + + G T H A G ++V+ L + + DL I + Sbjct: 130 NIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKK 174 Score = 37.7 bits (86), Expect = 0.004, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 32/94 (34%), Gaps = 7/94 (7%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L+ AC V+ L L Q+++ G LH + +I LL+K +L Sbjct: 110 LYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLR 169 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 + +A + SL + D Sbjct: 170 NIEKK-------LAFDMATNAACASLLKKKQGTD 196 >6E2G-A nrPDB Length = 727 Score = 100 bits (249), Expect = 5e-22, Method: Composition-based stats. Identities = 49/214 (22%), Positives = 76/214 (35%), Gaps = 22/214 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A EN + +LL + + QK G LH + + E L+ + Sbjct: 48 PLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVF 107 Query: 65 DDYPDD--SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITN-----------QGVTCL 111 + + G T HIA N+ +V++L R + G L Sbjct: 108 EPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPL 167 Query: 112 HLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSL----KLIELLC-----GL 162 A E+ + LIE+GA +R +D LH + ++ LL Sbjct: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDH 227 Query: 163 GKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 KS + QG TP A EG+ L++K Sbjct: 228 LKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 261 Score = 82.8 bits (203), Expect = 1e-16, Method: Composition-based stats. Identities = 34/171 (19%), Positives = 63/171 (36%), Gaps = 21/171 (12%) Query: 74 TPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG--- 130 +P +A N++ + L ++++ G T LH+A E + L+E Sbjct: 47 SPLLLAAKENNVQALIKLLKFE-GCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPEL 105 Query: 131 --ASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ-------------GW 175 + + Q LH A ++ L+ L G ++V+ + G Sbjct: 106 VFEPMTSELYEGQTALHIAVINQNVNLVRALLARG-ASVSARATGSVFHYRPHNLIYYGE 164 Query: 176 TPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLN 226 PL A G + LL+E +GA+ D+ G + + + K F Sbjct: 165 HPLSFAACVGSEEIVRLLIE-HGADIRAQDSLGNTVLHILILQPNKTFACQ 214 Score = 50.4 bits (119), Expect = 6e-07, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 39/103 (37%), Gaps = 18/103 (17%) Query: 4 YPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLH---------WSVSFQAHEITSF 54 +PL A V+ L+ + Q D G LH ++ Sbjct: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQ-DSLGNTVLHILILQPNKTFACQMYN-----L 218 Query: 55 LLSK-MENV--NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDR 94 LLS + +L+ P++ G TPF +A GN+ + + L + Sbjct: 219 LLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 261 >1BLX-B nrPDB Length = 166 Score = 99.0 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 32/151 (21%), Positives = 60/151 (39%), Gaps = 7/151 (4%) Query: 43 SVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNK 102 + + + LL + + D + G T + G+ V L + P++ Sbjct: 15 AAARGDVQEVRRLLHR--ELVHPDALNRFGKTALQV-MMFGSPAVALELLKQGASPNVQ- 70 Query: 103 ITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGL 162 G + +H A + + + L+E+GA V D +P+H A G ++ L Sbjct: 71 -DASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAP- 128 Query: 163 GKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 +S ++ +D G TPL A G + +L Sbjct: 129 -ESDLHHRDASGLTPLELARQRGAQNLMDIL 158 Score = 89.7 bits (221), Expect = 9e-19, Method: Composition-based stats. Identities = 39/158 (24%), Positives = 69/158 (43%), Gaps = 7/158 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L A + +V+ LLH + ++ G+ L + F + + LL + + N+ Sbjct: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSPAVALELLKQGASPNV- 69 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D SG +P H A G L+ +K L + D+N + + G +HLA+ + V F Sbjct: 70 --QDASGTSPVHDAARTGFLDTLKVLVEHG--ADVNALDSTGSLPIHLAIREGHSSVVSF 125 Query: 126 LIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG 163 L + + +D PL A G+ L+++L G Sbjct: 126 L-APESDLHHRDASGLTPLELARQRGAQNLMDILQGHM 162 Score = 56.2 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 53/142 (37%), Gaps = 41/142 (28%) Query: 79 ACSVGNLEVVKSLYDRPL-KPD-LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIK 136 A + G+++ V+ L R L PD LN+ + + E L++ GAS Sbjct: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALE----LLKQGASP--- 67 Query: 137 DKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 N QD G +P+ A G D +LVE Sbjct: 68 -------------------------------NVQDASGTSPVHDAARTGFLDTLKVLVE- 95 Query: 197 YGAEYDLVDNKGAKAEDVALNE 218 +GA+ + +D+ G+ +A+ E Sbjct: 96 HGADVNALDSTGSLPIHLAIRE 117 Score = 34.3 bits (77), Expect = 0.042, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 19/55 (34%), Gaps = 2/55 (3%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKM 59 P+H A E V L S L +D G PL + A + L M Sbjct: 110 PIHLAIREGHSSVVSFLAPE--SDLHHRDASGLTPLELARQRGAQNLMDILQGHM 162 >6DMR-A nrPDB Length = 730 Score = 95.9 bits (237), Expect = 1e-20, Method: Composition-based stats. Identities = 49/219 (22%), Positives = 81/219 (36%), Gaps = 23/219 (10%) Query: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 + + PL QA EN+ ++ LL ++ Q+ G LH + + E + L+ Sbjct: 44 IRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLMEAAP 103 Query: 61 NVNLDDY--PDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITN-----------QG 107 + + G T HIA NL +V++L R G Sbjct: 104 ELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYG 163 Query: 108 VTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSL----KLIELLCGLG 163 L A E+ + LIE+GA +R +D LH + ++ LL Sbjct: 164 EHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD 223 Query: 164 KSAVNWQ------DKQGWTPLFHALAEGHGDAAVLLVEK 196 + + + Q + QG TP A EG+ L++K Sbjct: 224 EHSDHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Score = 73.5 bits (179), Expect = 7e-14, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 72/231 (31%), Gaps = 44/231 (19%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 ++P+ + E +V L Q+++ PL + + LL Sbjct: 21 SWPVGEQDWEQYRDRVNML---------QQERIRDSPLLQAAKENDLRLLKILLLN--QS 69 Query: 63 NLDDYPDDSGWTPFHIACSVGNLEVVKSLY-------DRPLKPDLNKITNQGVTCLHLAV 115 G T H+A NLE L P + G T LH+AV Sbjct: 70 CDFQQRGAVGETALHVAALYDNLEAATLLMEAAPELAKEPALCEP----FVGQTALHIAV 125 Query: 116 GKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGW 175 + + + L+ GASV RA + L G Sbjct: 126 MNQNLNLVRALLARGASVSA----------RATGAAFRRSPHNLIYY-----------GE 164 Query: 176 TPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLN 226 PL A G + LL+E +GA+ D+ G + + + K F Sbjct: 165 HPLSFAACVGSEEIVRLLIE-HGADIRAQDSLGNTVLHILILQPNKTFACQ 214 >2RFA-A nrPDB Length = 232 Score = 93.2 bits (230), Expect = 8e-20, Method: Composition-based stats. Identities = 49/214 (22%), Positives = 77/214 (35%), Gaps = 22/214 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A EN+ + +LL + + Q+ G LH + + E L+ + Sbjct: 6 PLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVF 65 Query: 65 DDYPDD--SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITN-----------QGVTCL 111 + + G T HIA N+ +V++L R + G L Sbjct: 66 EPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPL 125 Query: 112 HLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHR---------AASVGSLKLIELLCGL 162 A E+ + LIE+GA +R +D LH A + +L L Sbjct: 126 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDH 185 Query: 163 GKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 KS + QG TP A EG+ L++K Sbjct: 186 LKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 Score = 74.7 bits (182), Expect = 3e-14, Method: Composition-based stats. Identities = 33/171 (19%), Positives = 63/171 (36%), Gaps = 21/171 (12%) Query: 74 TPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG--- 130 +P +A +++ + L ++++ G T LH+A E + L+E Sbjct: 5 SPLLLAAKENDVQALSKLLKFE-GCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPEL 63 Query: 131 --ASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ-------------GW 175 + + Q LH A ++ L+ L G ++V+ + G Sbjct: 64 VFEPMTSELYEGQTALHIAVINQNVNLVRALLARG-ASVSARATGSVFHYRPHNLIYYGE 122 Query: 176 TPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLN 226 PL A G + LL+E +GA+ D+ G + + + K F Sbjct: 123 HPLSFAACVGSEEIVRLLIE-HGADIRAQDSLGNTVLHILILQPNKTFACQ 172 Score = 45.0 bits (105), Expect = 2e-05, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 37/102 (36%), Gaps = 16/102 (15%) Query: 4 YPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLH---------WSVSFQAHEITSF 54 +PL A V+ L+ + Q D G LH ++ Sbjct: 123 HPLSFAACVGSEEIVRLLIEHGADIRAQ-DSLGNTVLHILILQPNKTFACQMYNL----L 177 Query: 55 LLSKMENV--NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDR 94 L + +L+ P++ G TPF +A GN+ + + L + Sbjct: 178 LSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 >6BOA-A nrPDB Length = 742 Score = 93.2 bits (230), Expect = 8e-20, Method: Composition-based stats. Identities = 46/215 (21%), Positives = 77/215 (35%), Gaps = 23/215 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL A +N+ + +LL + + Q+ G LH + + E L+ + Sbjct: 48 PLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVF 107 Query: 65 DDYPDD--SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVTCL 111 + + G T HIA N+ +V++L R G L Sbjct: 108 EPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPL 167 Query: 112 HLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSL----KLIELLCGLGKSAV 167 A E+ + LIE+GA +R +D LH + ++ LL + Sbjct: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGD 227 Query: 168 NWQ------DKQGWTPLFHALAEGHGDAAVLLVEK 196 + Q + QG TP A EG+ L++K Sbjct: 228 HLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Score = 78.9 bits (193), Expect = 1e-15, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 61/171 (35%), Gaps = 21/171 (12%) Query: 74 TPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENG--- 130 +P +A +++ + L +++ G T LH+A E + L+E Sbjct: 47 SPLLLAAKDNDVQALNKLLKYE-DCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPEL 105 Query: 131 --ASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDK-------------QGW 175 + + Q LH A ++ L+ L +++V+ + G Sbjct: 106 VFEPMTSELYEGQTALHIAVVNQNMNLVRALLAR-RASVSARATGTAFRRSPCNLIYFGE 164 Query: 176 TPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLN 226 PL A + LL+E +GA+ D+ G + + + K F Sbjct: 165 HPLSFAACVNSEEIVRLLIE-HGADIRAQDSLGNTVLHILILQPNKTFACQ 214 Score = 49.3 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 36/101 (35%), Gaps = 13/101 (12%) Query: 4 YPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLH---------WSVSFQAHEITSF 54 +PL A N V+ L+ + Q D G LH ++ + + Sbjct: 165 HPLSFAACVNSEEIVRLLIEHGADIRAQ-DSLGNTVLHILILQPNKTFACQM--YNLLLS 221 Query: 55 LLSKMENVNLDDYPDDS-GWTPFHIACSVGNLEVVKSLYDR 94 +++ D + G TPF +A GN + + L + Sbjct: 222 YDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 >3T9K-A nrPDB Length = 390 Score = 78.2 bits (191), Expect = 3e-15, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 40/104 (38%), Gaps = 3/104 (2%) Query: 56 LSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAV 115 L+ +VN TP A + +L + L ++N+ + G LH A Sbjct: 220 LAHGADVN-WVNGGQDNATPLIQATAANSLLACEFLLQNG--ANVNQADSAGRGPLHHAT 276 Query: 116 GKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 ++ ++ GA + +D + PL A + ++ LL Sbjct: 277 ILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 69.7 bits (169), Expect = 9e-13, Method: Composition-based stats. Identities = 29/125 (23%), Positives = 44/125 (35%), Gaps = 3/125 (2%) Query: 92 YDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVG 151 + T L A +FL++NGA+V D + PLH A +G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 152 SLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL-VEKYGAEYDLVDNKG-A 209 L L G + + +D +G PL A+ + D LL + K G Sbjct: 280 HTGLACLFLKRG-ADLGARDSEGRDPLTIAMETANADIVTLLRLAKMREAEAAQGQAGDE 338 Query: 210 KAEDV 214 D+ Sbjct: 339 TYLDI 343 Score = 67.0 bits (162), Expect = 6e-12, Method: Composition-based stats. Identities = 30/100 (30%), Positives = 43/100 (43%), Gaps = 4/100 (4%) Query: 127 IENGASVRIKD--KFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAE 184 + +GA V + + N PL +A + SL E L G + VN D G PL HA Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNG-ANVNQADSAGRGPLHHATIL 278 Query: 185 GHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFF 224 GH A L + K GA+ D++G +A+ Sbjct: 279 GHTGLACLFL-KRGADLGARDSEGRDPLTIAMETANADIV 317 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 39/106 (36%), Gaps = 6/106 (5%) Query: 22 LHSKPSLL-LQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIAC 80 L + + QD PL + + + FLL NVN D +G P H A Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVN---QADSAGRGPLHHAT 276 Query: 81 SVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFL 126 +G+ + R DL ++G L +A+ ++ L Sbjct: 277 ILGHTGLACLFLKRG--ADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 60.5 bits (145), Expect = 7e-10, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 4/87 (4%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 PL QA N + LL + ++ Q D GR PLH + + L + ++ Sbjct: 238 PLIQATAANSLLACEFLLQNGANVN-QADSAGRGPLHHATILGHTGLACLFLKRGADLGA 296 Query: 65 DDYPDDSGWTPFHIACSVGNLEVVKSL 91 D G P IA N ++V L Sbjct: 297 R---DSEGRDPLTIAMETANADIVTLL 320 >4BSZ-B nrPDB Length = 202 Score = 74.3 bits (181), Expect = 4e-14, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 69/177 (38%), Gaps = 17/177 (9%) Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKI---TNQGVTCLHLAVGKKWF 120 + D + G+L+ +K ++ + P+L + T LH+A Sbjct: 6 HSEPLDQEDQDTIILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHI 65 Query: 121 EVSQFLIE----------NGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 E ++++E A V +K LH A+ G L +++LLC ++ + Sbjct: 66 ETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCDEYEADPFIR 125 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDN----KGAKAEDVALNEQVKKF 223 +K G +F A G + ++KY E + + +G + + ++++ Sbjct: 126 NKFGHDAIFEAENSGKEEVETYFLKKYDVEPEDDEEDTQTEGKNSVQITKGTEIEQV 182 Score = 54.7 bits (130), Expect = 3e-08, Method: Composition-based stats. Identities = 22/135 (16%), Positives = 45/135 (33%), Gaps = 12/135 (8%) Query: 6 LHQACMENEFFKVQELLHSKPSL----LLQKDQDGRIPLHWSVSFQAHEITSFLLSKMEN 61 + + ++++ + S ++ + LH + + E ++L + Sbjct: 18 IILDARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSR 77 Query: 62 VNLDDYPD-------DSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLA 114 N + +G T H A G L+VVK L D + D G + A Sbjct: 78 ANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKLLCD-EYEADPFIRNKFGHDAIFEA 136 Query: 115 VGKKWFEVSQFLIEN 129 EV + ++ Sbjct: 137 ENSGKEEVETYFLKK 151 >5DND-A nrPDB Length = 588 Score = 73.5 bits (179), Expect = 7e-14, Method: Composition-based stats. Identities = 32/150 (21%), Positives = 57/150 (38%), Gaps = 5/150 (3%) Query: 10 CMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPD 69 E +Q L+ L L KD +G+ LH + + + LL + +VN D Sbjct: 430 AHAGELEALQALMELGSDLRL-KDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNAR---D 485 Query: 70 DSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIEN 129 G +P +A + E ++ L + + G LA E Q + Sbjct: 486 RDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRAD-MEGLQAWGQA 544 Query: 130 GASVRIKDKFNQIPLHRAASVGSLKLIELL 159 GA ++ + L A + G+ +++ LL Sbjct: 545 GADLQQPGYDGRSALCVAEAAGNQEVLALL 574 Score = 73.5 bits (179), Expect = 7e-14, Method: Composition-based stats. Identities = 35/150 (23%), Positives = 53/150 (35%), Gaps = 10/150 (6%) Query: 80 CSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKF 139 G LE +++L + L DL + G T LH+A V L+ G V +D+ Sbjct: 430 AHAGELEALQALME--LGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRD 487 Query: 140 NQIPLHRAASVGSLKLIELLCGLGKSAVNWQD--KQGWTPLFHALAEGHGDAAVLLVEKY 197 PL A + I LL G + ++ QD G A + Sbjct: 488 GLSPLLLAVQGRHRECIRLLRKAG-ACLSPQDLKDAGTELCRLASRADMEGLQAW--GQA 544 Query: 198 GAEYDLVDNKGAKAE---DVALNEQVKKFF 224 GA+ G A + A N++V Sbjct: 545 GADLQQPGYDGRSALCVAEAAGNQEVLALL 574 Score = 73.5 bits (179), Expect = 7e-14, Method: Composition-based stats. Identities = 37/153 (24%), Positives = 63/153 (41%), Gaps = 4/153 (2%) Query: 42 WSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLN 101 +++ L + ME + D +G T H+A G VV L R + D+N Sbjct: 425 LALALAHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGM--DVN 482 Query: 102 KITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQ-IPLHRAASVGSLKLIELLC 160 G++ L LAV + E + L + GA + +D + L R AS ++ ++ Sbjct: 483 ARDRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQA-W 541 Query: 161 GLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLL 193 G + + G + L A A G+ + LL Sbjct: 542 GQAGADLQQPGYDGRSALCVAEAAGNQEVLALL 574 Score = 60.1 bits (144), Expect = 7e-10, Method: Composition-based stats. Identities = 28/121 (23%), Positives = 43/121 (35%), Gaps = 5/121 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 LH A V LLH + +D+DG PL +V + E L ++ Sbjct: 459 LHVAARNGRDGVVTMLLHRGMDVN-ARDRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQ 517 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 D D T S ++E +++ DL + G + L +A EV Sbjct: 518 DLKDAG--TELCRLASRADMEGLQA--WGQAGADLQQPGYDGRSALCVAEAAGNQEVLAL 573 Query: 126 L 126 L Sbjct: 574 L 574 >1D9S-A nrPDB Length = 136 Score = 72.4 bits (176), Expect = 1e-13, Method: Composition-based stats. Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 5/121 (4%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A + G +E V+ L + P N + G + + + +V++ L+ +GA D Sbjct: 19 AAARGQVETVRQLLEAGADP--NALNRFGRRPIQV-MMMGSAQVAELLLLHGAEPNCADP 75 Query: 139 FNQI-PLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKY 197 P+H AA G L + +L G + ++ D G P+ A +GH D A L Sbjct: 76 ATLTRPVHDAAREGFLDTLVVLHRAG-ARLDVCDAWGRLPVDLAEEQGHRDIARYLHAAT 134 Query: 198 G 198 G Sbjct: 135 G 135 Score = 71.2 bits (173), Expect = 4e-13, Method: Composition-based stats. Identities = 21/126 (16%), Positives = 43/126 (34%), Gaps = 5/126 (3%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + E LL + N + G P + +G+ +V + L +P+ Sbjct: 16 LATAAARGQVETVRQLLEAGADPNA---LNRFGRRPIQV-MMMGSAQVAELLLLHGAEPN 71 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 +H A + + + L GA + + D + ++P+ A G + L Sbjct: 72 CAD-PATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLPVDLAEEQGHRDIARYL 130 Query: 160 CGLGKS 165 Sbjct: 131 HAATGD 136 Score = 60.1 bits (144), Expect = 7e-10, Method: Composition-based stats. Identities = 31/128 (24%), Positives = 55/128 (42%), Gaps = 4/128 (3%) Query: 97 KPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLI 156 P ++ + L A + E + L+E GA ++F + P+ +GS ++ Sbjct: 2 SPGIHMLGGSSDAGLATAAARGQVETVRQLLEAGADPNALNRFGRRPIQVMM-MGSAQVA 60 Query: 157 ELLCGLGKSAVNWQDKQGWT-PLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 ELL G + N D T P+ A EG D ++++ + GA D+ D G D+A Sbjct: 61 ELLLLHG-AEPNCADPATLTRPVHDAAREGFLD-TLVVLHRAGARLDVCDAWGRLPVDLA 118 Query: 216 LNEQVKKF 223 + + Sbjct: 119 EEQGHRDI 126 Score = 35.4 bits (80), Expect = 0.020, Method: Composition-based stats. Identities = 12/79 (15%), Positives = 21/79 (26%), Gaps = 3/79 (3%) Query: 13 NEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSG 72 + LL P+H + + L D D G Sbjct: 55 GSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGA---RLDVCDAWG 111 Query: 73 WTPFHIACSVGNLEVVKSL 91 P +A G+ ++ + L Sbjct: 112 RLPVDLAEEQGHRDIARYL 130 >2A5E-A nrPDB Length = 156 Score = 71.2 bits (173), Expect = 3e-13, Method: Composition-based stats. Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 5/121 (4%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A + G +E V++L + P N + G + + + V++ L+ +GA D Sbjct: 19 AAARGRVEEVRALLEAGALP--NAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADP 75 Query: 139 FNQI-PLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKY 197 P+H AA G L + +L G + ++ +D G P+ A GH D A L Sbjct: 76 ATLTRPVHDAAREGFLDTLVVLHRAG-ARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 134 Query: 198 G 198 G Sbjct: 135 G 135 Score = 68.2 bits (165), Expect = 3e-12, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 44/120 (36%), Gaps = 5/120 (4%) Query: 40 LHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 L + + E LL N P+ G P + +G+ V + L +P+ Sbjct: 16 LATAAARGRVEEVRALLEAGALPNA---PNSYGRRPIQV-MMMGSARVAELLLLHGAEPN 71 Query: 100 LNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELL 159 +H A + + + L GA + ++D + ++P+ A +G + L Sbjct: 72 CAD-PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130 Score = 61.2 bits (147), Expect = 3e-10, Method: Composition-based stats. Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 4/103 (3%) Query: 114 AVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 A + E + L+E GA + + + P+ +GS ++ ELL G + N D Sbjct: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMM-MGSARVAELLLLHG-AEPNCADPA 76 Query: 174 GWT-PLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 T P+ A EG D ++++ + GA D+ D G D+A Sbjct: 77 TLTRPVHDAAREGFLD-TLVVLHRAGARLDVRDAWGRLPVDLA 118 Score = 35.8 bits (81), Expect = 0.014, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 22/79 (27%), Gaps = 3/79 (3%) Query: 13 NEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSG 72 + LL P+H + + L D D G Sbjct: 55 GSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGA---RLDVRDAWG 111 Query: 73 WTPFHIACSVGNLEVVKSL 91 P +A +G+ +V + L Sbjct: 112 RLPVDLAEELGHRDVARYL 130 >3UI2-A nrPDB Length = 244 Score = 70.5 bits (171), Expect = 6e-13, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 51/124 (41%), Gaps = 11/124 (8%) Query: 25 KPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGN 84 ++ + + + + S LL + D D++G T +G+ Sbjct: 38 AADVVSEYETPWWT----AARKADEQALSQLLEDRDV----DAVDENGRTALLFVAGLGS 89 Query: 85 LEVVKSLYDRPLKPDLNKITNQG-VTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIP 143 + V+ L + DL+ +G +T LH+A G EV + L+E GA + ++D+ Sbjct: 90 DKCVRLLAEAG--ADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTA 147 Query: 144 LHRA 147 L A Sbjct: 148 LELA 151 Score = 65.8 bits (159), Expect = 1e-11, Method: Composition-based stats. Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 4/108 (3%) Query: 109 TCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVN 168 T A K + L+E+ V D+ + L A +GS K + LL G + ++ Sbjct: 47 TPWWTAARKADEQALSQLLED-RDVDAVDENGRTALLFVAGLGSDKCVRLLAEAG-ADLD 104 Query: 169 WQD-KQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 +D + G T L A + LVE GA+ ++ D +G A ++A Sbjct: 105 HRDMRGGLTALHMAAGYVRPEVVEALVE-LGADIEVEDERGLTALELA 151 Score = 51.2 bits (121), Expect = 4e-07, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 27/74 (36%), Gaps = 3/74 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L V+ L + L + + G LH + + E+ L+ ++ ++ Sbjct: 81 LLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVE 140 Query: 66 DYPDDSGWTPFHIA 79 D+ G T +A Sbjct: 141 ---DERGLTALELA 151 >3DEO-A nrPDB Length = 183 Score = 70.1 bits (170), Expect = 8e-13, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 51/124 (41%), Gaps = 11/124 (8%) Query: 25 KPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGN 84 ++ + + + + S LL + D D++G T +G+ Sbjct: 37 AADVVSEYETPWWT----AARKADEQALSQLLEDRD----VDAVDENGRTALLFVAGLGS 88 Query: 85 LEVVKSLYDRPLKPDLNKITNQG-VTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIP 143 + V+ L + DL+ +G +T LH+A G EV + L+E GA + ++D+ Sbjct: 89 DKCVRLLAEAG--ADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTA 146 Query: 144 LHRA 147 L A Sbjct: 147 LELA 150 Score = 65.5 bits (158), Expect = 2e-11, Method: Composition-based stats. Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 4/108 (3%) Query: 109 TCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVN 168 T A K + L+E+ V D+ + L A +GS K + LL G + ++ Sbjct: 46 TPWWTAARKADEQALSQLLED-RDVDAVDENGRTALLFVAGLGSDKCVRLLAEAG-ADLD 103 Query: 169 WQD-KQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 +D + G T L A + LVE GA+ ++ D +G A ++A Sbjct: 104 HRDMRGGLTALHMAAGYVRPEVVEALVE-LGADIEVEDERGLTALELA 150 Score = 50.8 bits (120), Expect = 5e-07, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 27/74 (36%), Gaps = 3/74 (4%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L V+ L + L + + G LH + + E+ L+ ++ ++ Sbjct: 80 LLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHMAAGYVRPEVVEALVELGADIEVE 139 Query: 66 DYPDDSGWTPFHIA 79 D+ G T +A Sbjct: 140 ---DERGLTALELA 150 >6OO7-A nrPDB Length = 786 Score = 67.4 bits (163), Expect = 4e-12, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 61/187 (32%), Gaps = 37/187 (19%) Query: 11 MENEFFKVQELLHSKPS-------LLLQKDQD---GRIPLHWSVSFQAHEITSFLLSKME 60 + +Q LL + Q + G LH ++ ++ + L+ Sbjct: 127 QDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGA 186 Query: 61 NVNL----------DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKP-DLNKITNQGVT 109 NV+ D G P +A +VV L + P +P L + G T Sbjct: 187 NVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNT 246 Query: 110 CLH-------LAVGKKWFEVSQF--LIENGASV-------RIKDKFNQIPLHRAASVGSL 153 LH + V + L++ GA + I + PL AA G + Sbjct: 247 VLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKI 306 Query: 154 KLIELLC 160 ++ + + Sbjct: 307 EIFKHIL 313 Score = 61.6 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 31/155 (20%), Positives = 55/155 (35%), Gaps = 29/155 (18%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVTCLHLAVGKKW 119 G + HIA +L+ VK L + + G L LA K Sbjct: 161 RGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQ 220 Query: 120 FEVSQFLIENG---ASVRIKDKFNQIPLH--RAASVGSLKLIELLCGLGKSAVNW----- 169 ++V +L+EN AS++ +D LH + S + L+ + + Sbjct: 221 WDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLC 280 Query: 170 --------QDKQGWTPLFHALAEGHGDAAVLLVEK 196 + +G TPL A EG + ++++ Sbjct: 281 PNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQR 315 Score = 59.3 bits (142), Expect = 1e-09, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 56/150 (37%), Gaps = 26/150 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLL-------LQKDQD-----GRIPLHWSVSFQAHEITS 53 LH A + V+ L+ + ++ QK+QD G +PL + + ++ + Sbjct: 166 LHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVN 225 Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACSVGNLE------VVKS---LYDRPLK--PDLNK 102 +LL D G T H + + VV+ L + P++ Sbjct: 226 YLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARLCPNVQL 285 Query: 103 I---TNQGVTCLHLAVGKKWFEVSQFLIEN 129 +G+T L LA + E+ + +++ Sbjct: 286 EGIPNLEGLTPLKLAAKEGKIEIFKHILQR 315 Score = 57.4 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 59/158 (37%), Gaps = 30/158 (18%) Query: 97 KPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKF-------------NQIP 143 +G + LH+A+ K+ + + L+ENGA+V K ++P Sbjct: 152 NAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELP 211 Query: 144 LHRAASVGSLKLIELLCG--LGKSAVNWQDKQGWTPLF---HALAEGHGDAAVLL----- 193 L AA ++ L +++ QD G T L + ++A+++ Sbjct: 212 LSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDG 271 Query: 194 VEKYGAE--YDLV-----DNKGAKAEDVALNEQVKKFF 224 + + GA ++ + +G +A E + F Sbjct: 272 LLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIF 309 Score = 52.7 bits (125), Expect = 1e-07, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 44/117 (37%), Gaps = 15/117 (12%) Query: 5 PLHQACMENEFFKVQELLH--SKPSLLLQKDQDGRIPLHWSV------SFQAHEITSF-- 54 PL A ++ V LL +P+ L +D G LH V + + + Sbjct: 211 PLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYD 270 Query: 55 -LLSKME----NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ 106 LL NV L+ P+ G TP +A G +E+ K + R ++ + Sbjct: 271 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRK 327 >5AN8-A nrPDB Length = 613 Score = 66.6 bits (161), Expect = 9e-12, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 59/187 (31%), Gaps = 37/187 (19%) Query: 11 MENEFFKVQELLHSKPS-------LLLQKDQD---GRIPLHWSVSFQAHEITSFLLSKME 60 + +Q LL + Q + G LH ++ ++ + L+ Sbjct: 52 QDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGA 111 Query: 61 NVNL----------DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK-PDLNKITNQGVT 109 NV+ D G P +A +VV L + P L + G T Sbjct: 112 NVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVNYLLENPHPAASLQAQDSLGNT 171 Query: 110 CLH------LAVGKKWFEVSQF---LIENGASV-------RIKDKFNQIPLHRAASVGSL 153 LH + V + L++ GA + I + PL AA G + Sbjct: 172 VLHALVMIADNSPENSALVVRMYDGLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKI 231 Query: 154 KLIELLC 160 ++ + + Sbjct: 232 EIFKHIL 238 Score = 60.5 bits (145), Expect = 6e-10, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 57/155 (36%), Gaps = 29/155 (18%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVTCLHLAVGKKW 119 G + HIA +L+ VK L + + G L LA K Sbjct: 86 RGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQ 145 Query: 120 FEVSQFLIENG---ASVRIKDKFNQIPLH-RAASVGS--------LKLIELLCGLGKS-A 166 ++V +L+EN AS++ +D LH + +++ + L G Sbjct: 146 WDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYDGLLQAGARLC 205 Query: 167 VNWQ-----DKQGWTPLFHALAEGHGDAAVLLVEK 196 N Q + +G TPL A EG + ++++ Sbjct: 206 PNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQR 240 Score = 57.8 bits (138), Expect = 3e-09, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 55/150 (36%), Gaps = 26/150 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLL-------LQKDQD-----GRIPLHWSVSFQAHEITS 53 LH A + V+ L+ + ++ QK+QD G +PL + + ++ + Sbjct: 91 LHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTKQWDVVN 150 Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACSVGN---------LEVVKSLYDRPLK--PDLNK 102 +LL D G T H + + + + L + P++ Sbjct: 151 YLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYDGLLQAGARLCPNVQL 210 Query: 103 I---TNQGVTCLHLAVGKKWFEVSQFLIEN 129 +G+T L LA + E+ + +++ Sbjct: 211 EGIPNLEGLTPLKLAAKEGKIEIFKHILQR 240 Score = 50.4 bits (119), Expect = 5e-07, Method: Composition-based stats. Identities = 27/117 (23%), Positives = 43/117 (36%), Gaps = 15/117 (12%) Query: 5 PLHQACMENEFFKVQELLH--SKPSLLLQKDQDGRIPLHWSV--SFQAHE----ITSF-- 54 PL A ++ V LL + L +D G LH V + + E + Sbjct: 136 PLSLAACTKQWDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYD 195 Query: 55 -LLSKME----NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ 106 LL NV L+ P+ G TP +A G +E+ K + R ++ + Sbjct: 196 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQREFSAPCQSLSRK 252 >6DVZ-A nrPDB Length = 791 Score = 65.1 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 43/253 (16%), Positives = 84/253 (33%), Gaps = 58/253 (22%) Query: 9 ACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYP 68 A E +++ELL L ++ + ++ FL+ Sbjct: 126 AVSEGCVEELRELLQDLQDLCRRR--------------RGLDVPDFLM-------HKLTA 164 Query: 69 DDSGWTPFHIACSV---GNLEVVKSLY---------DRPLKPDLNKITNQGVTCLHLAVG 116 D+G T A E+V+ L DR + + + +G T L++A+ Sbjct: 165 SDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIE 224 Query: 117 KKWFEVSQFLIENGASVRIKDKF--------------NQIPLHRAASVGSLKLIELLCGL 162 ++ +++ LI GA V K + PL AA ++++LL Sbjct: 225 RRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEN 284 Query: 163 GKSAVNWQDKQGWTPLFHALA-----EGHGDAAV-----LLVEKYGAEY-DLVDNKGAKA 211 ++ + QD +G L + + D +L+ E + +N G Sbjct: 285 EQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTP 344 Query: 212 EDVALNEQVKKFF 224 +A + Sbjct: 345 LQLAAKMGKAEIL 357 Score = 63.9 bits (154), Expect = 5e-11, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 56/150 (37%), Gaps = 24/150 (16%) Query: 35 DGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD-----------SGWTPFHIACSVG 83 +G+ L+ ++ + +IT+ L++ +VN G TP +A Sbjct: 214 EGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTN 273 Query: 84 NLEVVKSLYDRPLKPDLNKITNQGVTCLH--------LAVGKKWFEVS--QFLIENG--A 131 E+V+ L + D+ ++G LH + + L+ +G Sbjct: 274 QPEIVQLLMENEQT-DITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE 332 Query: 132 SVRIKDKFNQIPLHRAASVGSLKLIELLCG 161 +++ PL AA +G ++++ + Sbjct: 333 LETMRNNDGLTPLQLAAKMGKAEILKYILS 362 Score = 48.5 bits (114), Expect = 2e-06, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 44/103 (42%), Gaps = 11/103 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQ-----AHEITS-----F 54 PL A N+ VQ L+ ++ + + +D G LH V+ ++ Sbjct: 265 PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMI 324 Query: 55 LLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL N L+ ++ G TP +A +G E++K + R +K Sbjct: 325 LLRSG-NWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIK 366 >6BO5-A nrPDB Length = 695 Score = 64.7 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 54/162 (33%), Gaps = 29/162 (17%) Query: 28 LLLQKDQD--GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD----------SGWTP 75 D+ G LH ++ ++ + L+ +V+L G P Sbjct: 114 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 173 Query: 76 FHIACSVGNLEVVKSLYDRPLKP-DLNKITNQGVTCLHLAVG--KKWFEVSQF------- 125 +A +VV L + P +P L + G T LH V E S Sbjct: 174 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 233 Query: 126 LIENGASV-------RIKDKFNQIPLHRAASVGSLKLIELLC 160 L++ GA + I + PL AA G +++ + Sbjct: 234 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHIL 275 Score = 63.1 bits (152), Expect = 8e-11, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 49/154 (31%), Gaps = 29/154 (18%) Query: 72 GWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVTCLHLAVGKKWF 120 G + HIA +L+ VK L + L G L LA K + Sbjct: 124 GHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQW 183 Query: 121 EVSQFLIENG---ASVRIKDKFNQIPLH-RAASVGSLKLIELLCGLGKSAV--------- 167 +V +L+EN AS+ D LH + L + Sbjct: 184 DVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCP 243 Query: 168 -----NWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 + QG TPL A EG + ++++ Sbjct: 244 TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 277 Score = 58.5 bits (140), Expect = 2e-09, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 58/158 (36%), Gaps = 30/158 (18%) Query: 97 KPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKF-------------NQIP 143 QG + LH+A+ K+ + + L+ENGA V ++ ++P Sbjct: 114 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 173 Query: 144 LHRAASVGSLKLIELLCG--LGKSAVNWQDKQGWTPLF---HALAEGHGDAAVLL----- 193 L AA ++ L +++ D G T L ++A+++ Sbjct: 174 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 233 Query: 194 VEKYGAEY-------DLVDNKGAKAEDVALNEQVKKFF 224 + + GA ++ +++G +A E + F Sbjct: 234 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIF 271 Score = 53.9 bits (128), Expect = 5e-08, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 53/150 (35%), Gaps = 26/150 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLL-------LQKDQD-----GRIPLHWSVSFQAHEITS 53 LH A + V+ L+ + + QK Q G +PL + + ++ + Sbjct: 128 LHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVT 187 Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACSV-----GNLEVVKS----LYDRPLK--PDLNK 102 +LL + D G T H + N +V L + P + Sbjct: 188 YLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQL 247 Query: 103 ---ITNQGVTCLHLAVGKKWFEVSQFLIEN 129 +QG+T L LA + E+ + +++ Sbjct: 248 EEISNHQGLTPLKLAAKEGKIEIFRHILQR 277 Score = 48.5 bits (114), Expect = 2e-06, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 41/108 (37%), Gaps = 15/108 (13%) Query: 5 PLHQACMENEFFKVQELLH--SKPSLLLQKDQDGRIPLHWSV--SFQAHEITSF------ 54 PL A ++ V LL +P+ L D G LH V + + E ++ Sbjct: 173 PLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYD 232 Query: 55 -LLSKME----NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL V L++ + G TP +A G +E+ + + R Sbjct: 233 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFS 280 >5HI9-A nrPDB Length = 770 Score = 64.7 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 54/162 (33%), Gaps = 29/162 (17%) Query: 28 LLLQKDQD--GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD----------SGWTP 75 D+ G LH ++ ++ + L+ +V+L G P Sbjct: 154 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 213 Query: 76 FHIACSVGNLEVVKSLYDRPLKP-DLNKITNQGVTCLHLAVG--KKWFEVSQF------- 125 +A +VV L + P +P L + G T LH V E S Sbjct: 214 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 273 Query: 126 LIENGASV-------RIKDKFNQIPLHRAASVGSLKLIELLC 160 L++ GA + I + PL AA G +++ + Sbjct: 274 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHIL 315 Score = 63.1 bits (152), Expect = 8e-11, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 49/154 (31%), Gaps = 29/154 (18%) Query: 72 GWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVTCLHLAVGKKWF 120 G + HIA +L+ VK L + L G L LA K + Sbjct: 164 GHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQW 223 Query: 121 EVSQFLIENG---ASVRIKDKFNQIPLH-RAASVGSLKLIELLCGLGKSAV--------- 167 +V +L+EN AS+ D LH + L + Sbjct: 224 DVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCP 283 Query: 168 -----NWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 + QG TPL A EG + ++++ Sbjct: 284 TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 317 Score = 58.5 bits (140), Expect = 2e-09, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 58/158 (36%), Gaps = 30/158 (18%) Query: 97 KPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKF-------------NQIP 143 QG + LH+A+ K+ + + L+ENGA V ++ ++P Sbjct: 154 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 213 Query: 144 LHRAASVGSLKLIELLCG--LGKSAVNWQDKQGWTPLF---HALAEGHGDAAVLL----- 193 L AA ++ L +++ D G T L ++A+++ Sbjct: 214 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 273 Query: 194 VEKYGAEY-------DLVDNKGAKAEDVALNEQVKKFF 224 + + GA ++ +++G +A E + F Sbjct: 274 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIF 311 Score = 53.9 bits (128), Expect = 5e-08, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 53/150 (35%), Gaps = 26/150 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLL-------LQKDQD-----GRIPLHWSVSFQAHEITS 53 LH A + V+ L+ + + QK Q G +PL + + ++ + Sbjct: 168 LHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVT 227 Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACSV-----GNLEVVKS----LYDRPLK--PDLNK 102 +LL + D G T H + N +V L + P + Sbjct: 228 YLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQL 287 Query: 103 ---ITNQGVTCLHLAVGKKWFEVSQFLIEN 129 +QG+T L LA + E+ + +++ Sbjct: 288 EEISNHQGLTPLKLAAKEGKIEIFRHILQR 317 Score = 48.5 bits (114), Expect = 2e-06, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 41/108 (37%), Gaps = 15/108 (13%) Query: 5 PLHQACMENEFFKVQELLH--SKPSLLLQKDQDGRIPLHWSV--SFQAHEITSF------ 54 PL A ++ V LL +P+ L D G LH V + + E ++ Sbjct: 213 PLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYD 272 Query: 55 -LLSKME----NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL V L++ + G TP +A G +E+ + + R Sbjct: 273 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFS 320 >2F37-A nrPDB Length = 251 Score = 63.5 bits (153), Expect = 7e-11, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 53/152 (34%), Gaps = 27/152 (17%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD----------SGWTPFHIACSVGNL 85 G LH ++ ++ + L+ NV+ G P +A Sbjct: 95 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 154 Query: 86 EVVKSLYDRPLKP-DLNKITNQGVTCLHLAVG--KKWFEVSQF-------LIENGASV-- 133 +VV L + P +P L +QG T LH V E L++ GA + Sbjct: 155 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 214 Query: 134 -----RIKDKFNQIPLHRAASVGSLKLIELLC 160 I++ + PL AA G +++ + Sbjct: 215 TVQLEDIRNLQDLTPLKLAAKEGKIEIFRHIL 246 Score = 60.1 bits (144), Expect = 7e-10, Method: Composition-based stats. Identities = 36/165 (21%), Positives = 58/165 (35%), Gaps = 30/165 (18%) Query: 62 VNLDDYPDDS-GWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVT 109 VN D G + HIA +L+ VK L + G Sbjct: 84 VNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGEL 143 Query: 110 CLHLAVGKKWFEVSQFLIENG---ASVRIKDKFNQIPLH--RAASVGSLKLIELLCGLGK 164 L LA K ++V +L+EN AS++ D LH S S + I L+ + Sbjct: 144 PLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 203 Query: 165 SAV-------------NWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 + + ++ Q TPL A EG + ++++ Sbjct: 204 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 Score = 52.4 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 52/150 (34%), Gaps = 26/150 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLL-------LQKDQD-----GRIPLHWSVSFQAHEITS 53 LH A + V+ L+ + ++ QK Q G +PL + + ++ S Sbjct: 99 LHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVS 158 Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACS-----VGNLEVVKS----LYDRPLK--PDLNK 102 +LL D G T H N+ +V S L + P + Sbjct: 159 YLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQL 218 Query: 103 ITNQG---VTCLHLAVGKKWFEVSQFLIEN 129 + +T L LA + E+ + +++ Sbjct: 219 EDIRNLQDLTPLKLAAKEGKIEIFRHILQR 248 Score = 47.7 bits (112), Expect = 4e-06, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 39/108 (36%), Gaps = 15/108 (13%) Query: 5 PLHQACMENEFFKVQELLH--SKPSLLLQKDQDGRIPLHWSV--SFQAHEITSF------ 54 PL A ++ V LL +P+ L D G LH V S + E + Sbjct: 144 PLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 203 Query: 55 -LLSKME----NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL V L+D + TP +A G +E+ + + R Sbjct: 204 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFS 251 >5U0K-A nrPDB Length = 141 Score = 63.1 bits (152), Expect = 9e-11, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 34/83 (40%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 L A + + + KD ++ LH AA+ G +++++ L K + Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 88 Query: 171 DKQGWTPLFHALAEGHGDAAVLL 193 D+ G PL A+ H + LL Sbjct: 89 DRWGNIPLDDAVQFNHLEVVKLL 111 Score = 60.8 bits (146), Expect = 4e-10, Method: Composition-based stats. Identities = 23/91 (25%), Positives = 40/91 (43%), Gaps = 3/91 (3%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIEN-GASVR 134 A G++ ++ + D+ + T LH+A + EV +FLIE + Sbjct: 29 LLFAAYSGDVSALRRFALSAM--DMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPF 86 Query: 135 IKDKFNQIPLHRAASVGSLKLIELLCGLGKS 165 KD++ IPL A L++++LL S Sbjct: 87 AKDRWGNIPLDDAVQFNHLEVVKLLQDYQDS 117 Score = 58.5 bits (140), Expect = 2e-09, Method: Composition-based stats. Identities = 23/86 (26%), Positives = 32/86 (37%), Gaps = 3/86 (3%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L A + ++ S + QKD D R LH + + E+ FL+ Sbjct: 29 LLFAAYSGDVSALRRFALSAMD-MEQKDYDSRTALHVAAAEGHIEVVKFLIE--ACKVNP 85 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSL 91 D G P A +LEVVK L Sbjct: 86 FAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 52.4 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 18/61 (29%), Positives = 26/61 (42%), Gaps = 1/61 (1%) Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 + D T H+A + G++EVVK L + K + G L AV EV + Sbjct: 52 EQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKL 110 Query: 126 L 126 L Sbjct: 111 L 111 Score = 44.7 bits (104), Expect = 3e-05, Method: Composition-based stats. Identities = 19/74 (25%), Positives = 26/74 (35%), Gaps = 1/74 (1%) Query: 144 LHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDL 203 L AA G + + L + +D T L A AEGH + L+E Sbjct: 29 LLFAAYSGDVSALR-RFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFA 87 Query: 204 VDNKGAKAEDVALN 217 D G D A+ Sbjct: 88 KDRWGNIPLDDAVQ 101 >4N5Q-A nrPDB Length = 257 Score = 62.8 bits (151), Expect = 1e-10, Method: Composition-based stats. Identities = 43/253 (16%), Positives = 84/253 (33%), Gaps = 58/253 (22%) Query: 9 ACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYP 68 A E +++ELL L ++ + ++ FL+ Sbjct: 10 AVSEGCVEELRELLQDLQDLCRRR--------------RGLDVPDFLM-------HKLTA 48 Query: 69 DDSGWTPFHIACSV---GNLEVVKSLY---------DRPLKPDLNKITNQGVTCLHLAVG 116 D+G T A E+V+ L DR + + + +G T L++A+ Sbjct: 49 SDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIE 108 Query: 117 KKWFEVSQFLIENGASVRIKDKF--------------NQIPLHRAASVGSLKLIELLCGL 162 ++ +++ LI GA V K + PL AA ++++LL Sbjct: 109 RRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEN 168 Query: 163 GKSAVNWQDKQGWTPLFHALA-----EGHGDAAV-----LLVEKYGAEY-DLVDNKGAKA 211 ++ + QD +G L + + D +L+ E + +N G Sbjct: 169 EQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTP 228 Query: 212 EDVALNEQVKKFF 224 +A + Sbjct: 229 LQLAAKMGKAEIL 241 Score = 62.4 bits (150), Expect = 2e-10, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 56/150 (37%), Gaps = 24/150 (16%) Query: 35 DGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD-----------SGWTPFHIACSVG 83 +G+ L+ ++ + +IT+ L++ +VN G TP +A Sbjct: 98 EGQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTN 157 Query: 84 NLEVVKSLYDRPLKPDLNKITNQGVTCLH--------LAVGKKWFEVS--QFLIENG--A 131 E+V+ L + D+ ++G LH + + L+ +G Sbjct: 158 QPEIVQLLMENEQT-DITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE 216 Query: 132 SVRIKDKFNQIPLHRAASVGSLKLIELLCG 161 +++ PL AA +G ++++ + Sbjct: 217 LETMRNNDGLTPLQLAAKMGKAEILKYILS 246 Score = 47.4 bits (111), Expect = 6e-06, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 44/103 (42%), Gaps = 11/103 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQ-----AHEITS-----F 54 PL A N+ VQ L+ ++ + + +D G LH V+ ++ Sbjct: 149 PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMI 208 Query: 55 LLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL N L+ ++ G TP +A +G E++K + R +K Sbjct: 209 LLRSG-NWELETMRNNDGLTPLQLAAKMGKAEILKYILSREIK 250 >5IRX-A nrPDB Length = 636 Score = 62.0 bits (149), Expect = 2e-10, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 57/153 (37%), Gaps = 28/153 (18%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWT-----------PFHIACSVGN 84 G+ LH ++ + + + L+ +V D T P +A Sbjct: 96 GQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQ 155 Query: 85 LEVVKSLYDRPLKP-DLNKITNQGVTCLH--LAVGKKWFEVSQF-------LIENGASVR 134 L +VK L +P D++ + G T LH + V + ++F ++ GA + Sbjct: 156 LAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLH 215 Query: 135 -------IKDKFNQIPLHRAASVGSLKLIELLC 160 I ++ PL AAS G + ++ + Sbjct: 216 PTLKLEEITNRKGLTPLALAASSGKIGVLAYIL 248 Score = 59.3 bits (142), Expect = 1e-09, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 63/192 (32%), Gaps = 43/192 (22%) Query: 67 YPDDSGWTPFHIAC---SVGNLEVVKSLY---------DRPLKPDLNKITNQGVTCLHLA 114 ++G T A G + + L + + +G T LH+A Sbjct: 44 KDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIA 103 Query: 115 VGKKWFEVSQFLIENGASVRIKDKF--------------NQIPLHRAASVGSLKLIELLC 160 + ++ + L+ENGA V+ ++PL AA L +++ L Sbjct: 104 IERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLL 163 Query: 161 GLG--KSAVNWQDKQGWTPLFHALA--EGHGDAAVLLVEKY------GAEYD-------L 203 + ++ +D G T L + + D + Y GA+ + Sbjct: 164 QNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEI 223 Query: 204 VDNKGAKAEDVA 215 + KG +A Sbjct: 224 TNRKGLTPLALA 235 Score = 58.1 bits (139), Expect = 3e-09, Method: Composition-based stats. Identities = 35/220 (15%), Positives = 70/220 (31%), Gaps = 41/220 (18%) Query: 18 VQELLHSKPSLLLQKDQDGRIPLHWSV---SFQAHEITSFLL-------SKMENVNLDDY 67 +Q + + G+ L ++ ++ + LL S + VN Sbjct: 31 LQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYT 90 Query: 68 PDDS-GWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLA 114 G T HIA N+ +V L + + G L LA Sbjct: 91 DSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLA 150 Query: 115 VGKKWFEVSQFLIEN---GASVRIKDKFNQIPLH----RAASV-GSLKLIELLCGL---G 163 + +FL++N A + +D LH A + + K + + Sbjct: 151 ACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILIL 210 Query: 164 KSAVN-------WQDKQGWTPLFHALAEGHGDAAVLLVEK 196 + ++ +++G TPL A + G ++++ Sbjct: 211 GAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQR 250 Score = 50.4 bits (119), Expect = 6e-07, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 43/151 (28%), Gaps = 27/151 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQD-------------GRIPLHWSVSFQAHEIT 52 LH A V L+ + + + D G +PL + I Sbjct: 100 LHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIV 159 Query: 53 SFLLSKMENVNLDDYPDDSGWTPFHIACSVG-----NLEVVK------SLYDRPLKPDLN 101 FLL D G T H V N + V + L P L Sbjct: 160 KFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLK 219 Query: 102 K---ITNQGVTCLHLAVGKKWFEVSQFLIEN 129 +G+T L LA V ++++ Sbjct: 220 LEEITNRKGLTPLALAASSGKIGVLAYILQR 250 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 27/128 (21%), Positives = 51/128 (39%), Gaps = 20/128 (15%) Query: 5 PLHQACMENEFFKVQELLHSK--PSLLLQKDQDGRIPLHW--SVSFQAHEITSF------ 54 PL A N+ V+ LL + P+ + +D G LH V+ + T F Sbjct: 146 PLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYN 205 Query: 55 -LLSKMENVN----LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK-PDLNKITNQ-- 106 +L ++ L++ + G TP +A S G + V+ + R + P+ ++ + Sbjct: 206 EILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFT 265 Query: 107 --GVTCLH 112 +H Sbjct: 266 EWAYGPVH 273 >2ETB-A nrPDB Length = 256 Score = 61.6 bits (148), Expect = 2e-10, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 54/162 (33%), Gaps = 29/162 (17%) Query: 28 LLLQKDQD--GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD----------SGWTP 75 D+ G LH ++ ++ + L+ +V+L G P Sbjct: 80 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 139 Query: 76 FHIACSVGNLEVVKSLYDRPLKP-DLNKITNQGVTCLHLAVG--KKWFEVSQF------- 125 +A +VV L + P +P L + G T LH V E S Sbjct: 140 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 199 Query: 126 LIENGASV-------RIKDKFNQIPLHRAASVGSLKLIELLC 160 L++ GA + I + PL AA G +++ + Sbjct: 200 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHIL 241 Score = 60.8 bits (146), Expect = 5e-10, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 49/154 (31%), Gaps = 29/154 (18%) Query: 72 GWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ-----------GVTCLHLAVGKKWF 120 G + HIA +L+ VK L + L G L LA K + Sbjct: 90 GHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQW 149 Query: 121 EVSQFLIENG---ASVRIKDKFNQIPLH-RAASVGSLKLIELLCGLGKSAV--------- 167 +V +L+EN AS+ D LH + L + Sbjct: 150 DVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCP 209 Query: 168 -----NWQDKQGWTPLFHALAEGHGDAAVLLVEK 196 + QG TPL A EG + ++++ Sbjct: 210 TVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 243 Score = 56.2 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 58/158 (36%), Gaps = 30/158 (18%) Query: 97 KPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKF-------------NQIP 143 QG + LH+A+ K+ + + L+ENGA V ++ ++P Sbjct: 80 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 139 Query: 144 LHRAASVGSLKLIELLCG--LGKSAVNWQDKQGWTPLF---HALAEGHGDAAVLL----- 193 L AA ++ L +++ D G T L ++A+++ Sbjct: 140 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 199 Query: 194 VEKYGAEY-------DLVDNKGAKAEDVALNEQVKKFF 224 + + GA ++ +++G +A E + F Sbjct: 200 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIF 237 Score = 51.6 bits (122), Expect = 2e-07, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 53/150 (35%), Gaps = 26/150 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLL-------LQKDQD-----GRIPLHWSVSFQAHEITS 53 LH A + V+ L+ + + QK Q G +PL + + ++ + Sbjct: 94 LHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVT 153 Query: 54 FLLSKMENVNLDDYPDDSGWTPFHIACSVGN---------LEVVKSLYDRPLK--PDLNK 102 +LL + D G T H + + + + L + P + Sbjct: 154 YLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQL 213 Query: 103 ---ITNQGVTCLHLAVGKKWFEVSQFLIEN 129 +QG+T L LA + E+ + +++ Sbjct: 214 EEISNHQGLTPLKLAAKEGKIEIFRHILQR 243 Score = 46.6 bits (109), Expect = 9e-06, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 41/108 (37%), Gaps = 15/108 (13%) Query: 5 PLHQACMENEFFKVQELLH--SKPSLLLQKDQDGRIPLHWSV--SFQAHEITSF------ 54 PL A ++ V LL +P+ L D G LH V + + E ++ Sbjct: 139 PLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYD 198 Query: 55 -LLSKME----NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL V L++ + G TP +A G +E+ + + R Sbjct: 199 GLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFS 246 >6CUD-A nrPDB Length = 806 Score = 60.8 bits (146), Expect = 4e-10, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 52/144 (36%), Gaps = 29/144 (20%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A GN+ VV+ + + ++N + G L LAVG + EV++ L++ RI D Sbjct: 34 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 92 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGK------------------SAVNWQDKQGW----- 175 L A S G ++++E + D+ G Sbjct: 93 ----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 148 Query: 176 -TPLFHALAEGHGDAAVLLVEKYG 198 TP+ A + +L+ K Sbjct: 149 ITPIILAAHCQKYEVVHMLLMKGA 172 Score = 57.4 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 38/227 (16%), Positives = 71/227 (31%), Gaps = 38/227 (16%) Query: 8 QACMENEFFKVQELLHSKPSLLLQK-DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDD 66 A V+++L +L + D G+ L +V + E+T LL K NL Sbjct: 33 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK---ENLAR 89 Query: 67 YPDDSGWTPFHIACSVGNLEVVKSLYDRP-----------------LKPDLNKITNQGV- 108 D +A S G + +V+++ + P D G Sbjct: 90 IGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 144 Query: 109 -----TCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLG 163 T + LA + +EV L+ GA + + Sbjct: 145 FSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDS-----FSHS 199 Query: 164 KSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210 +S +N K +P + +L+ L + A+ ++ + Sbjct: 200 RSRINAY-KGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKN 245 >2NYJ-A nrPDB Length = 273 Score = 60.8 bits (146), Expect = 5e-10, Method: Composition-based stats. Identities = 30/153 (19%), Positives = 57/153 (37%), Gaps = 28/153 (18%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWT-----------PFHIACSVGN 84 G+ LH ++ + + + L+ +V D T P +A Sbjct: 101 GQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQ 160 Query: 85 LEVVKSLYDRPLKP-DLNKITNQGVTCLH--LAVGKKWFEVSQF-------LIENGASVR 134 L +VK L +P D++ + G T LH + V + ++F ++ GA + Sbjct: 161 LAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLH 220 Query: 135 -------IKDKFNQIPLHRAASVGSLKLIELLC 160 I ++ PL AAS G + ++ + Sbjct: 221 PTLKLEEITNRKGLTPLALAASSGKIGVLAYIL 253 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 34/192 (17%), Positives = 64/192 (33%), Gaps = 43/192 (22%) Query: 67 YPDDSGWTPFHIAC---SVGNLEVVKSLY---------DRPLKPDLNKITNQGVTCLHLA 114 ++G T A G + + L + + +G T LH+A Sbjct: 49 KDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIA 108 Query: 115 VGKKWFEVSQFLIENGASVRIKDKF--------------NQIPLHRAASVGSLKLIELLC 160 + ++ + L+ENGA V+ ++PL AA L +++ L Sbjct: 109 IERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLL 168 Query: 161 GLG--KSAVNWQDKQGWTPLF--HALAEGHGDAAVLLVEKY------GAEYD-------L 203 + ++ +D G T L +A+ D + Y GA+ + Sbjct: 169 QNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEI 228 Query: 204 VDNKGAKAEDVA 215 + KG +A Sbjct: 229 TNRKGLTPLALA 240 Score = 56.6 bits (135), Expect = 8e-09, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 52/156 (33%), Gaps = 30/156 (19%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLAVGKK 118 G T HIA N+ +V L + + G L LA Sbjct: 100 KGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTN 159 Query: 119 WFEVSQFLIEN---GASVRIKDKFNQIPLH----RAASV-GSLKLIELLCGL---GKSAV 167 + +FL++N A + +D LH A + + K + + + + Sbjct: 160 QLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKL 219 Query: 168 N-------WQDKQGWTPLFHALAEGHGDAAVLLVEK 196 + +++G TPL A + G ++++ Sbjct: 220 HPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQR 255 Score = 49.3 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 43/151 (28%), Gaps = 27/151 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQD-------------GRIPLHWSVSFQAHEIT 52 LH A V L+ + + + D G +PL + I Sbjct: 105 LHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIV 164 Query: 53 SFLLSKMENVNLDDYPDDSGWTPFHIACSVG-----NLEVVK------SLYDRPLKPDLN 101 FLL D G T H V N + V + L P L Sbjct: 165 KFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLK 224 Query: 102 K---ITNQGVTCLHLAVGKKWFEVSQFLIEN 129 +G+T L LA V ++++ Sbjct: 225 LEEITNRKGLTPLALAASSGKIGVLAYILQR 255 Score = 43.9 bits (102), Expect = 6e-05, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 44/108 (40%), Gaps = 15/108 (13%) Query: 5 PLHQACMENEFFKVQELLHSK--PSLLLQKDQDGRIPLHW--SVSFQAHEITSF------ 54 PL A N+ V+ LL + P+ + +D G LH V+ + T F Sbjct: 151 PLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYN 210 Query: 55 -LLSKMENVN----LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 +L ++ L++ + G TP +A S G + V+ + R + Sbjct: 211 EILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIH 258 >4XD0-A nrPDB Length = 417 Score = 60.5 bits (145), Expect = 6e-10, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 53/148 (35%), Gaps = 9/148 (6%) Query: 20 ELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIA 79 L+ S ++ D + + ++ E S LL N+ + GW+P IA Sbjct: 275 HLILSTIDYDIKLYSDNFDEILTACEDKSPEFISKLLKT---ENILFEKNHLGWSPIIIA 331 Query: 80 CSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLH----LAVGKKWFEVSQFLIENGASVRI 135 GN++V++ L + ++N +G T + + + LI G + + Sbjct: 332 AYHGNMDVIEWLVSKG--VNINDRNYKGTTVAMYFKDYMLRSGNYTGLENLINLGLDLFL 389 Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLG 163 KD +++L + Sbjct: 390 KDNEGLSVFDYMRKNKNIELFNFMSTFN 417 Score = 35.4 bits (80), Expect = 0.020, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 42/104 (40%), Gaps = 6/104 (5%) Query: 114 AVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 A K E L++ + K+ P+ AA G++ +IE L G +N ++ + Sbjct: 298 ACEDKSPEFISKLLKTENILFEKNHLGWSPIIIAAYHGNMDVIEWLVSKG-VNINDRNYK 356 Query: 174 GWTPLF----HALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAED 213 G T + L G+ L+ G + L DN+G D Sbjct: 357 GTTVAMYFKDYMLRSGNYTGLENLIN-LGLDLFLKDNEGLSVFD 399 >3W9G-A nrPDB Length = 260 Score = 60.5 bits (145), Expect = 7e-10, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 57/159 (35%), Gaps = 28/159 (17%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLD------DYPDDSGW-----TPFHIACSVGN 84 G+ LH ++ + L+ K +V+ D+ G+ P +A Sbjct: 93 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 152 Query: 85 LEVVKSLYDRPLK-PDLNKITNQGVTCLH--LAVGKKWFEVSQF-------LIENGA--- 131 +V L + K DL + ++G T LH +A+ E ++F L+ A Sbjct: 153 PHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLF 212 Query: 132 -SVRIK---DKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 ++ + PL AA G + + + + + Sbjct: 213 PDTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRREIAD 251 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 47/160 (29%), Gaps = 30/160 (18%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLAVGKK 118 G T HIA V+ L ++ G L LA Sbjct: 92 RGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 151 Query: 119 WFEVSQFLIENG---ASVRIKDKFNQIPLH-RAASVGS-----------LKLIELLCGLG 163 + +L ENG A +R +D LH A + L+ + C Sbjct: 152 QPHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKL 211 Query: 164 KSAVNWQ---DKQGWTPLFHALAEGHGDAAVLLVEKYGAE 200 N + + G +PL A G ++ + A+ Sbjct: 212 FPDTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRREIAD 251 Score = 52.0 bits (123), Expect = 2e-07, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 41/151 (27%), Gaps = 27/151 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQ--------KDQDGRI-----PLHWSVSFQAHEIT 52 LH A V+ L+ + Q KD+ G PL + I Sbjct: 97 LHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIV 156 Query: 53 SFLLSKMENVNLDDYPDDSGWTPFH-IACSVGNLEVVKSLYDRPLK----------PDLN 101 +L D G T H + N + PD N Sbjct: 157 HYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLFPDTN 216 Query: 102 ---KITNQGVTCLHLAVGKKWFEVSQFLIEN 129 + N G++ L +A + Q +I Sbjct: 217 LEALLNNDGLSPLMMAAKTGKIGIFQHIIRR 247 >1DCQ-A nrPDB Length = 278 Score = 60.1 bits (144), Expect = 9e-10, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 42/98 (42%), Gaps = 4/98 (4%) Query: 109 TCLHLAVG---KKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKS 165 T LHLAV + + FL++N ++ + LH + + ++LL GK+ Sbjct: 171 TALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR-GKA 229 Query: 166 AVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDL 203 ++ ++ G TPL A H LL + ++ Sbjct: 230 SIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNS 267 Score = 54.7 bits (130), Expect = 3e-08, Method: Composition-based stats. Identities = 31/138 (22%), Positives = 51/138 (36%), Gaps = 11/138 (7%) Query: 40 LHWSVSF-QAHEITSFLLSKMENVNLDDYPDDSG-----WTPFHIACSV---GNLEVVKS 90 LH + +I L + + V+L + + T H+A +L +V Sbjct: 131 LHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDF 190 Query: 91 LYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASV 150 L +L+K T +G T LH E + L+ AS+ I ++ + PL A + Sbjct: 191 LVQN--SGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRL 248 Query: 151 GSLKLIELLCGLGKSAVN 168 ELL N Sbjct: 249 KHEHCEELLTQALSGRFN 266 Score = 43.9 bits (102), Expect = 6e-05, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 34/82 (41%), Gaps = 5/82 (6%) Query: 138 KFNQIPLHRAAS---VGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLV 194 + ++ LH A SL +++ L ++ Q +G T L + + + LL+ Sbjct: 167 EPDETALHLAVRSVDRTSLHIVDFLVQNSG-NLDKQTGKGSTALHYCCLTDNAECLKLLL 225 Query: 195 EKYGAEYDLVDNKGAKAEDVAL 216 + A ++ + G D+A Sbjct: 226 -RGKASIEIANESGETPLDIAK 246 Score = 41.2 bits (95), Expect = 4e-04, Method: Composition-based stats. Identities = 23/100 (23%), Positives = 38/100 (38%), Gaps = 8/100 (8%) Query: 6 LHQACMENE---FFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 LH A + V L+ + +L Q + G LH+ E LL ++ Sbjct: 173 LHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGK-GSTALHYCCLTDNAECLKLLLRGKASI 231 Query: 63 NLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNK 102 + ++SG TP IA + + E + L + L N Sbjct: 232 ---EIANESGETPLDIAKRLKH-EHCEELLTQALSGRFNS 267 >3LVQ-E nrPDB Length = 497 Score = 60.1 bits (144), Expect = 9e-10, Method: Composition-based stats. Identities = 20/87 (22%), Positives = 31/87 (35%), Gaps = 5/87 (5%) Query: 76 FHIACSVGN---LEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGAS 132 H+A V N L +V + D G T LH A + + L++ A Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAAD--GNTALHYAALYNQPDCLKLLLKGRAL 232 Query: 133 VRIKDKFNQIPLHRAASVGSLKLIELL 159 V ++ + L A + ELL Sbjct: 233 VGTVNEAGETALDIARKKHHKECEELL 259 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 37/87 (42%), Gaps = 4/87 (4%) Query: 110 CLHLA---VGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 LHLA + + F+I+NG + K LH AA ++LL G++ Sbjct: 174 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK-GRAL 232 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLL 193 V ++ G T L A + H + LL Sbjct: 233 VGTVNEAGETALDIARKKHHKECEELL 259 Score = 49.3 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 5/82 (6%) Query: 144 LHRA---ASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAE 200 LH A A+ SL L++ + G ++ + G T L +A D LL+ K A Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGG-HLDAKAADGNTALHYAALYNQPDCLKLLL-KGRAL 232 Query: 201 YDLVDNKGAKAEDVALNEQVKK 222 V+ G A D+A + K+ Sbjct: 233 VGTVNEAGETALDIARKKHHKE 254 Score = 44.7 bits (104), Expect = 3e-05, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 30/94 (31%), Gaps = 5/94 (5%) Query: 6 LHQAC--MENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVN 63 LH A + + + L K DG LH++ + + LL V Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALV- 233 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 +++G T IA + E + L Sbjct: 234 --GTVNEAGETALDIARKKHHKECEELLEQAQAG 265 Score = 35.4 bits (80), Expect = 0.019, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 1/71 (1%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 N LH A + N+ ++ LL + L+ ++ G L + E L Sbjct: 208 NTALHYAALYNQPDCLKLLLKGRA-LVGTVNEAGETALDIARKKHHKECEELLEQAQAGT 266 Query: 63 NLDDYPDDSGW 73 D W Sbjct: 267 FAFPLHVDYSW 277 >6DJS-A nrPDB Length = 676 Score = 59.7 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 52/144 (36%), Gaps = 29/144 (20%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A GN+ VV+ + + ++N + G L LAVG + EV++ L++ RI D Sbjct: 51 AAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD- 109 Query: 139 FNQIPLHRAASVGSLKLIELLCGLGK------------------SAVNWQDKQGW----- 175 L A S G ++++E + D+ G Sbjct: 110 ----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPD 165 Query: 176 -TPLFHALAEGHGDAAVLLVEKYG 198 TP+ A + +L+ K Sbjct: 166 ITPIILAAHCQKYEVVHMLLMKGA 189 Score = 55.8 bits (133), Expect = 1e-08, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 52/153 (33%), Gaps = 32/153 (20%) Query: 8 QACMENEFFKVQELLHSKPSLLLQK-DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDD 66 A V+++L +L + D G+ L +V + E+T LL K NL Sbjct: 50 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKK---ENLAR 106 Query: 67 YPDDSGWTPFHIACSVGNLEVVKSLYDRP-----------------LKPDLNKITNQGV- 108 D +A S G + +V+++ + P D G Sbjct: 107 IGD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTR 161 Query: 109 -----TCLHLAVGKKWFEVSQFLIENGASVRIK 136 T + LA + +EV L+ GA + Sbjct: 162 FSPDITPIILAAHCQKYEVVHMLLMKGARIERP 194 Score = 47.4 bits (111), Expect = 5e-06, Method: Composition-based stats. Identities = 20/175 (11%), Positives = 50/175 (28%), Gaps = 37/175 (21%) Query: 19 QELLHSKPSLLLQKDQDGRIPLHW----SVSFQAHEITSFLLSKMENVNLDDYPDDSGWT 74 + P+ + + + + +L + + +N++ D G Sbjct: 23 RRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCV-DYMGQN 81 Query: 75 PFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGA--- 131 +A +LEV + L + + L LA+ K + + + ++ + Sbjct: 82 ALQLAVGNEHLEVTELLLKKENLARIGD-------ALLLAISKGYVRIVEAILNHPGFAA 134 Query: 132 ----------------SVRIKDKFNQ------IPLHRAASVGSLKLIELLCGLGK 164 D+ P+ AA +++ +L G Sbjct: 135 SKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGA 189 >5UQE-A nrPDB Length = 520 Score = 59.7 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 35/83 (42%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 L A + + + +D ++ LH AA+ G +++++ L K + Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 480 Query: 171 DKQGWTPLFHALAEGHGDAAVLL 193 D+ TP+ AL GH D +L Sbjct: 481 DRWNNTPMDEALHFGHHDVFKIL 503 Score = 58.9 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 37/102 (36%), Gaps = 3/102 (2%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L A + ++ S + Q+D D R LH + + E+ FLL Sbjct: 421 LLFAAYTGDVSALRRFALSAMD-MEQRDYDSRTALHVAAAEGHVEVVKFLLE--ACKVNP 477 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQG 107 D TP A G+ +V K L + ++ ++ G Sbjct: 478 FPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNG 519 Score = 58.1 bits (139), Expect = 3e-09, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 37/88 (42%), Gaps = 3/88 (3%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIEN-GASVR 134 A G++ ++ + D+ + T LH+A + EV +FL+E + Sbjct: 421 LLFAAYTGDVSALRRFALSAM--DMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPF 478 Query: 135 IKDKFNQIPLHRAASVGSLKLIELLCGL 162 KD++N P+ A G + ++L Sbjct: 479 PKDRWNNTPMDEALHFGHHDVFKILQEY 506 Score = 50.4 bits (119), Expect = 7e-07, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 27/64 (42%), Gaps = 1/64 (1%) Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 + D T H+A + G++EVVK L + K + T + A+ +V + Sbjct: 444 EQRDYDSRTALHVAAAEGHVEVVKFLLE-ACKVNPFPKDRWNNTPMDEALHFGHHDVFKI 502 Query: 126 LIEN 129 L E Sbjct: 503 LQEY 506 Score = 45.4 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 19/73 (26%), Positives = 25/73 (34%), Gaps = 1/73 (1%) Query: 144 LHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDL 203 L AA G + + L + +D T L A AEGH + L+E Sbjct: 421 LLFAAYTGDVSALR-RFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFP 479 Query: 204 VDNKGAKAEDVAL 216 D D AL Sbjct: 480 KDRWNNTPMDEAL 492 >2B0O-E nrPDB Length = 301 Score = 58.1 bits (139), Expect = 3e-09, Method: Composition-based stats. Identities = 20/87 (22%), Positives = 31/87 (35%), Gaps = 5/87 (5%) Query: 76 FHIACSVGN---LEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGAS 132 H+A V N L +V + D G T LH A + + L++ A Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAAD--GNTALHYAALYNQPDCLKLLLKGRAL 251 Query: 133 VRIKDKFNQIPLHRAASVGSLKLIELL 159 V ++ + L A + ELL Sbjct: 252 VGTVNEAGETALDIARKKHHKECEELL 278 Score = 55.8 bits (133), Expect = 1e-08, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 37/87 (42%), Gaps = 4/87 (4%) Query: 110 CLHLA---VGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSA 166 LHLA + + F+I+NG + K LH AA ++LL G++ Sbjct: 193 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK-GRAL 251 Query: 167 VNWQDKQGWTPLFHALAEGHGDAAVLL 193 V ++ G T L A + H + LL Sbjct: 252 VGTVNEAGETALDIARKKHHKECEELL 278 Score = 47.7 bits (112), Expect = 4e-06, Method: Composition-based stats. Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 5/82 (6%) Query: 144 LHRA---ASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAE 200 LH A A+ SL L++ + G ++ + G T L +A D LL+ K A Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGG-HLDAKAADGNTALHYAALYNQPDCLKLLL-KGRAL 251 Query: 201 YDLVDNKGAKAEDVALNEQVKK 222 V+ G A D+A + K+ Sbjct: 252 VGTVNEAGETALDIARKKHHKE 273 Score = 43.5 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 30/94 (31%), Gaps = 5/94 (5%) Query: 6 LHQAC--MENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVN 63 LH A + + + L K DG LH++ + + LL V Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALV- 252 Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 +++G T IA + E + L Sbjct: 253 --GTVNEAGETALDIARKKHHKECEELLEQAQAG 284 Score = 34.6 bits (78), Expect = 0.037, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 1/71 (1%) Query: 3 NYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENV 62 N LH A + N+ ++ LL + L+ ++ G L + E L Sbjct: 227 NTALHYAALYNQPDCLKLLLKGRA-LVGTVNEAGETALDIARKKHHKECEELLEQAQAGT 285 Query: 63 NLDDYPDDSGW 73 D W Sbjct: 286 FAFPLHVDYSW 296 >6CV9-A nrPDB Length = 842 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 33/153 (21%), Positives = 54/153 (35%), Gaps = 32/153 (20%) Query: 8 QACMENEFFKVQELLHSKPSLLLQK-DQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDD 66 A V+++L SL + D G+ L +V+ + EIT LL K NL Sbjct: 15 DAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKK---ENLSR 71 Query: 67 YPDDSGWTPFHIACSVGNLEVVKSLYDRPLKP-----------------DLNKITNQG-- 107 D +A S G + +V+++ + P D G Sbjct: 72 VGD-----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTR 126 Query: 108 ----VTCLHLAVGKKWFEVSQFLIENGASVRIK 136 VT + LA + +E+ L+ GA + Sbjct: 127 FSHDVTPIILAAHCQEYEIVHTLLRKGARIERP 159 Score = 57.8 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 51/144 (35%), Gaps = 29/144 (20%) Query: 79 ACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDK 138 A GN+ VV+ + + ++N + G L LAV + E+++ L++ R+ D Sbjct: 16 AAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGD- 74 Query: 139 FNQIPLHRAASVGSLKLIELLCGL------------------GKSAVNWQDKQGW----- 175 L A S G ++++E + + D+ G Sbjct: 75 ----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHD 130 Query: 176 -TPLFHALAEGHGDAAVLLVEKYG 198 TP+ A + L+ K Sbjct: 131 VTPIILAAHCQEYEIVHTLLRKGA 154 Score = 52.7 bits (125), Expect = 1e-07, Method: Composition-based stats. Identities = 22/149 (14%), Positives = 45/149 (30%), Gaps = 37/149 (24%) Query: 43 SVSFQAHEITSFLL--SKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDL 100 + + + +L NVN DY G +A + +LE+ + L + + Sbjct: 16 AAEYGNIPVVRKMLEECHSLNVNCVDY---MGQNALQLAVANEHLEITELLLKKENLSRV 72 Query: 101 NKITNQGVTCLHLAVGKKWFEVSQFLIENGA-------------------SVRIKDKFNQ 141 L LA+ K + + + ++ + A D+ Sbjct: 73 GD-------ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGT 125 Query: 142 ------IPLHRAASVGSLKLIELLCGLGK 164 P+ AA +++ L G Sbjct: 126 RFSHDVTPIILAAHCQEYEIVHTLLRKGA 154 >4DX2-A nrPDB Length = 259 Score = 57.4 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 58/153 (37%), Gaps = 28/153 (18%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLD------DYPDDSGW-----TPFHIACSVGN 84 G+ LH ++ + L+++ +V+ D+ G+ P +A Sbjct: 91 GQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 150 Query: 85 LEVVKSLYDRP-LKPDLNKITNQGVTCLH--LAVGKKWFEVSQF-------LIENGA--- 131 +V L + P K D+ + ++G T LH +A+ E ++F L+ A Sbjct: 151 PHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLF 210 Query: 132 -SVRIK---DKFNQIPLHRAASVGSLKLIELLC 160 ++ + PL AA G + + + + Sbjct: 211 PDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHII 243 Score = 52.0 bits (123), Expect = 2e-07, Method: Composition-based stats. Identities = 29/160 (18%), Positives = 43/160 (26%), Gaps = 30/160 (18%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLAVGKK 118 G T HIA V+ L + G L LA Sbjct: 90 RGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 149 Query: 119 WFEVSQFLIENG---ASVRIKDKFNQIPLH-RAASVGS-----------LKLIELLCGLG 163 + +L EN A +R +D LH A + L+ L C Sbjct: 150 QPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARL 209 Query: 164 KSAVN---WQDKQGWTPLFHALAEGHGDAAVLLVEKYGAE 200 N + G +PL A G ++ + + Sbjct: 210 FPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTD 249 Score = 49.3 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 42/151 (27%), Gaps = 27/151 (17%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQ--------KDQDGRI-----PLHWSVSFQAHEIT 52 LH A V+ L+ + Q KD+ G PL + I Sbjct: 95 LHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIV 154 Query: 53 SFLLSKMENVNLDDYPDDSGWTPFH-IACSVGNLEVVKSLYDRPLK----------PDLN 101 ++L D G T H + N + PD N Sbjct: 155 NYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSN 214 Query: 102 K---ITNQGVTCLHLAVGKKWFEVSQFLIEN 129 + N G++ L +A + Q +I Sbjct: 215 LEAVLNNDGLSPLMMAAKTGKIGIFQHIIRR 245 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 27/150 (18%), Positives = 44/150 (29%), Gaps = 33/150 (22%) Query: 105 NQGVTCLHLAV---GKKWFEVSQFLIENGASVRIKDK-----------FNQIPLHRAASV 150 + G TCL A+ + L++ + Q LH A Sbjct: 42 STGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIER 101 Query: 151 GSLKLIELLCGLGKSAVNWQDK--------------QGWTPLFHALAEGHGDAAVLLVE- 195 +ELL G + V+ Q + G PL A L E Sbjct: 102 RCKHYVELLVAQG-ADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTEN 160 Query: 196 -KYGAEYDLVDNKGAKAED--VALNEQVKK 222 A+ D++G VA+ + ++ Sbjct: 161 PHKKADMRRQDSRGNTVLHALVAIADNTRE 190 >5U0J-A nrPDB Length = 140 Score = 56.2 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 35/83 (42%) Query: 111 LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 L A + + + +D ++ LH AA+ G +++++ L K + Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 87 Query: 171 DKQGWTPLFHALAEGHGDAAVLL 193 D+ TP+ AL GH D +L Sbjct: 88 DRWNNTPMDEALHFGHHDVFKIL 110 Score = 55.1 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 37/102 (36%), Gaps = 3/102 (2%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 L A + ++ S + Q+D D R LH + + E+ FLL Sbjct: 28 LLFAAYTGDVSALRRFALSAMD-MEQRDYDSRTALHVAAAEGHVEVVKFLLE--ACKVNP 84 Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQG 107 D TP A G+ +V K L + ++ ++ G Sbjct: 85 FPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNG 126 Score = 54.3 bits (129), Expect = 5e-08, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 37/88 (42%), Gaps = 3/88 (3%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIEN-GASVR 134 A G++ ++ + D+ + T LH+A + EV +FL+E + Sbjct: 28 LLFAAYTGDVSALRRFALSAM--DMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPF 85 Query: 135 IKDKFNQIPLHRAASVGSLKLIELLCGL 162 KD++N P+ A G + ++L Sbjct: 86 PKDRWNNTPMDEALHFGHHDVFKILQEY 113 Score = 47.0 bits (110), Expect = 6e-06, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 27/64 (42%), Gaps = 1/64 (1%) Query: 66 DYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQF 125 + D T H+A + G++EVVK L + K + T + A+ +V + Sbjct: 51 EQRDYDSRTALHVAAAEGHVEVVKFLLE-ACKVNPFPKDRWNNTPMDEALHFGHHDVFKI 109 Query: 126 LIEN 129 L E Sbjct: 110 LQEY 113 Score = 42.7 bits (99), Expect = 1e-04, Method: Composition-based stats. Identities = 19/73 (26%), Positives = 25/73 (34%), Gaps = 1/73 (1%) Query: 144 LHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDL 203 L AA G + + L + +D T L A AEGH + L+E Sbjct: 28 LLFAAYTGDVSALR-RFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFP 86 Query: 204 VDNKGAKAEDVAL 216 D D AL Sbjct: 87 KDRWNNTPMDEAL 99 >6C8G-A nrPDB Length = 675 Score = 55.4 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 60/163 (36%), Gaps = 28/163 (17%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLD------DYPDDSGW-----TPFHIACSVGN 84 G+ LH ++ + L+ K +V+ D+ G+ P +A Sbjct: 103 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 162 Query: 85 LEVVKSLYDRP-LKPDLNKITNQGVTCLH--LAVGKKWFEVSQF--------------LI 127 ++V L + K D+ + ++G T LH +A+ E ++F L Sbjct: 163 PDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLY 222 Query: 128 ENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 + + I + + PL AA +G + + + + L + Sbjct: 223 PDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLEIKDEEAR 265 Score = 53.1 bits (126), Expect = 9e-08, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 49/175 (28%), Gaps = 31/175 (17%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLAVGKK 118 G T HIA V+ L ++ G L LA Sbjct: 102 RGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 161 Query: 119 WFEVSQFLIENG---ASVRIKDKFNQIPLH--RAASVGSLKLIELLCGLGKSAVNWQ--- 170 ++ +L EN A +R +D LH A + + + + + + V Sbjct: 162 QPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKL 221 Query: 171 ----------DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 + +PL A G ++ + + + K D A Sbjct: 222 YPDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLEIKDEEAR-HLSRKFRDWA 275 Score = 46.6 bits (109), Expect = 8e-06, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 45/163 (27%), Gaps = 31/163 (19%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQ--------KDQDGRI-----PLHWSVSFQAHEIT 52 LH A V+ L+ + Q KD+ G PL + +I Sbjct: 107 LHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIV 166 Query: 53 SFLLSKMENVNLDDYPDDSGWTPFH-IACSVGNLEVVKSLYDRPLKPDLNKI-------- 103 +L D G T H + N + + K Sbjct: 167 HYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSS 226 Query: 104 -----TNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQ 141 N ++ L +A + Q +I + IKD+ + Sbjct: 227 LEAIFNNDSMSPLMMAAKLGKIGIFQHII----RLEIKDEEAR 265 >6BBJ-A nrPDB Length = 868 Score = 55.4 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 60/163 (36%), Gaps = 28/163 (17%) Query: 36 GRIPLHWSVSFQAHEITSFLLSKMENVNLD------DYPDDSGW-----TPFHIACSVGN 84 G+ LH ++ + L+ K +V+ D+ G+ P +A Sbjct: 234 GQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQ 293 Query: 85 LEVVKSLYDRP-LKPDLNKITNQGVTCLH--LAVGKKWFEVSQF--------------LI 127 ++V L + K D+ + ++G T LH +A+ E ++F L Sbjct: 294 PDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLY 353 Query: 128 ENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 + + I + + PL AA +G + + + + L + Sbjct: 354 PDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLEIKDEEAR 396 Score = 53.1 bits (126), Expect = 9e-08, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 49/175 (28%), Gaps = 31/175 (17%) Query: 71 SGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLAVGKK 118 G T HIA V+ L ++ G L LA Sbjct: 233 RGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTN 292 Query: 119 WFEVSQFLIENG---ASVRIKDKFNQIPLH--RAASVGSLKLIELLCGLGKSAVNWQ--- 170 ++ +L EN A +R +D LH A + + + + + + V Sbjct: 293 QPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKL 352 Query: 171 ----------DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 + +PL A G ++ + + + K D A Sbjct: 353 YPDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLEIKDEEAR-HLSRKFRDWA 406 Score = 46.6 bits (109), Expect = 8e-06, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 45/163 (27%), Gaps = 31/163 (19%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQ--------KDQDGRI-----PLHWSVSFQAHEIT 52 LH A V+ L+ + Q KD+ G PL + +I Sbjct: 238 LHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPDIV 297 Query: 53 SFLLSKMENVNLDDYPDDSGWTPFH-IACSVGNLEVVKSLYDRPLKPDLNKI-------- 103 +L D G T H + N + + K Sbjct: 298 HYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSS 357 Query: 104 -----TNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKDKFNQ 141 N ++ L +A + Q +I + IKD+ + Sbjct: 358 LEAIFNNDSMSPLMMAAKLGKIGIFQHII----RLEIKDEEAR 396 >6MHW-A nrPDB Length = 826 Score = 52.4 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 24/150 (16%), Positives = 54/150 (36%), Gaps = 24/150 (16%) Query: 35 DGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDD-----------SGWTPFHIACSVG 83 +G+ L+ ++ + +I + L++ +VN G TP +A Sbjct: 215 EGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTN 274 Query: 84 NLEVVKSLYDRPLKPDLNKITNQGVTCLH--------LAVGKKWFEVS--QFLIENG--A 131 E+V+ L + D+ ++G LH + + L+ +G Sbjct: 275 QPEIVQLLMEHEQT-DITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWE 333 Query: 132 SVRIKDKFNQIPLHRAASVGSLKLIELLCG 161 ++ PL AA +G ++++ + Sbjct: 334 LETTRNNDGLTPLQLAAKMGKAEILKYILS 363 Score = 50.8 bits (120), Expect = 4e-07, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 43/103 (41%), Gaps = 11/103 (10%) Query: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQ-----AHEITS-----F 54 PL A N+ VQ L+ + + + +D G LH V+ ++ Sbjct: 266 PLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMI 325 Query: 55 LLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLK 97 LL N L+ ++ G TP +A +G E++K + R +K Sbjct: 326 LLRSG-NWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIK 367 Score = 50.1 bits (118), Expect = 9e-07, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 60/198 (30%), Gaps = 35/198 (17%) Query: 34 QDGRIPLHWSVSF---QAHEITSFLLS-------KMENVNLDDYPDDS-GWTPFHIACSV 82 G+ L ++ EI LL+ +N + + G T +IA Sbjct: 167 DTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIER 226 Query: 83 GNLEVVKSLYDRPLKPDLNKITNQ------------GVTCLHLAVGKKWFEVSQFLIEN- 129 ++ L + + G T L LA E+ Q L+E+ Sbjct: 227 RQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHE 286 Query: 130 GASVRIKDKFNQIPLH--------RAASVGSLKLIE--LLCGLGKSAVNW-QDKQGWTPL 178 + +D LH +K + +L G + ++ G TPL Sbjct: 287 QTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPL 346 Query: 179 FHALAEGHGDAAVLLVEK 196 A G + ++ + Sbjct: 347 QLAAKMGKAEILKYILSR 364 Score = 46.6 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 45/162 (27%), Gaps = 34/162 (20%) Query: 80 CSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGK---KWFEVSQFLIENGASVRIK 136 C + E V L ++ G TCL A+ E+ + L+ I Sbjct: 147 CRRRHDEDVPDFLMHKLTA-----SDTGKTCLMKALLNINPNTKEIVRILLAFAEENDIL 201 Query: 137 DK-----------FNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDK------------- 172 + Q L+ A + L + VN K Sbjct: 202 GRFINAEYTEEAYEGQTALNIAIERRQGDIAAL-LIAAGADVNAHAKGAFFNPKYQHEGF 260 Query: 173 -QGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAED 213 G TPL A + LL+E + D++G Sbjct: 261 YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH 302 >6G1K-A nrPDB Length = 921 Score = 50.4 bits (119), Expect = 7e-07, Method: Composition-based stats. Identities = 31/134 (23%), Positives = 49/134 (36%), Gaps = 22/134 (16%) Query: 79 ACSVGNLEVVKSLYDRP---LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 A G+ VK + K ++N I G T L +A+ + E+ + L+ V Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYV-- 96 Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ------DKQ------GWTPLFHALA 183 LH A + +ELL K + Q DKQ TP+ A Sbjct: 97 ----GDALLH-AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAH 151 Query: 184 EGHGDAAVLLVEKY 197 + + +LV+K Sbjct: 152 TNNYEIIKMLVQKG 165 Score = 47.4 bits (111), Expect = 5e-06, Method: Composition-based stats. Identities = 26/135 (19%), Positives = 46/135 (34%), Gaps = 15/135 (11%) Query: 9 ACMENEFFKVQELLHSK----PSLLLQKDQDGRIPLHWSVSFQAHEITSFLLS----KME 60 A + ++ V+ L + D GR L ++ + EI LLS + Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGD 98 Query: 61 NVNLDDYPDDSGWTPFHIACSV--GNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKK 118 + + G + G +V L D+ I T + LA Sbjct: 99 ALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDI-----TPIILAAHTN 153 Query: 119 WFEVSQFLIENGASV 133 +E+ + L++ G SV Sbjct: 154 NYEIIKMLVQKGVSV 168 >5UIL-A nrPDB Length = 405 Score = 44.3 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 23/161 (14%), Positives = 51/161 (31%), Gaps = 43/161 (26%) Query: 8 QACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDY 67 +AC ++ + +L+ +K S+L +K+ G P+ + E+ +L+SK Sbjct: 284 EACKYSDSKYIAKLIRAK-SILFEKNIYGWSPVIVAAYHGNIELIKWLVSKGA------- 335 Query: 68 PDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGK----KWFEVS 123 ++N +G T + Sbjct: 336 -------------------------------NINDRNYKGTTVAMYFKDYMLKSGDYSGL 364 Query: 124 QFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGK 164 + LI+ G + + D + G+ L++ + K Sbjct: 365 KMLIDLGLDLTLTDYKDYTVFDYLEKSGNKNLLQYMMAFMK 405 >6BWI-A nrPDB Length = 977 Score = 35.8 bits (81), Expect = 0.014, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 39/129 (30%), Gaps = 14/129 (10%) Query: 76 FHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 +A + +++ +S R D+ + L A+ E + LI +G + Sbjct: 198 LRLAVAWNRVDIAQSELFRG---DIQWRSFHLEASLMDALLNDRPEFVRLLISHG----L 250 Query: 136 KDKFNQIPLHRAASVG---SLKLIELLCGLG--KSAVNWQDKQGWTPLFHALAEGHGDAA 190 P+ A S LI L + +G GH Sbjct: 251 SLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGH--VL 308 Query: 191 VLLVEKYGA 199 +L+ K A Sbjct: 309 RMLLGKMCA 317 >5Z96-A nrPDB Length = 755 Score = 34.3 bits (77), Expect = 0.049, Method: Composition-based stats. Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 22/134 (16%) Query: 79 ACSVGNLEVVKSLYDRP---LKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRI 135 A G+ VK + K ++N I G T L +A+ + E+ + L+ V Sbjct: 39 AVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYV-- 96 Query: 136 KDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ------DKQ------GWTPLFHALA 183 LH A + +ELL K + Q DKQ TP+ A Sbjct: 97 ----GDALLH-AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAH 151 Query: 184 EGHGDAAVLLVEKY 197 + + LLV+K Sbjct: 152 TNNYEIIKLLVQKG 165 Score = 33.1 bits (74), Expect = 0.097, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 47/135 (34%), Gaps = 15/135 (11%) Query: 9 ACMENEFFKVQELLHSK----PSLLLQKDQDGRIPLHWSVSFQAHEITSFLLS----KME 60 A + ++ V++ L + D GR L ++ + E+ LLS + Sbjct: 39 AVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGD 98 Query: 61 NVNLDDYPDDSGWTPFHIACSV--GNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKK 118 + + G + G +V L D+ I T + LA Sbjct: 99 ALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDI-----TPIILAAHTN 153 Query: 119 WFEVSQFLIENGASV 133 +E+ + L++ G SV Sbjct: 154 NYEIIKLLVQKGVSV 168 Score = 26.6 bits (57), Expect = 8.8, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 29/72 (40%), Gaps = 14/72 (19%) Query: 107 GVTCLHLAVGKKWFEVSQFLIEN----GAS---VRIKDKF------NQIPLHRAASVGSL 153 G LH A+ K+ + L+ + G + DK + P+ AA + Sbjct: 97 GDALLH-AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNY 155 Query: 154 KLIELLCGLGKS 165 ++I+LL G S Sbjct: 156 EIIKLLVQKGVS 167 >2DI3-A nrPDB Length = 239 Score = 31.2 bits (69), Expect = 0.36, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 20/49 (40%) Query: 35 DGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVG 83 +G LH S ++ LL KM++ +L FH+ S G Sbjct: 106 EGWAALHSSAERGDWDVAEALLEKMDDPSLPLEDFLRFDAEFHVVISKG 154 Score = 30.4 bits (67), Expect = 0.57, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 25/84 (29%), Gaps = 7/84 (8%) Query: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ------- 173 E + L G + A+ G + + L + V D Sbjct: 47 EALRVLEALGTISTATGSGPRSGTIITAAPGQALSLSVTLQLVTNQVGHHDIYETRQLLE 106 Query: 174 GWTPLFHALAEGHGDAAVLLVEKY 197 GW L + G D A L+EK Sbjct: 107 GWAALHSSAERGDWDVAEALLEKM 130 Score = 28.5 bits (62), Expect = 2.3, Method: Composition-based stats. Identities = 10/63 (15%), Positives = 21/63 (33%), Gaps = 1/63 (1%) Query: 57 SKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTC-LHLAV 115 + + GW H + G+ +V ++L ++ P L H+ + Sbjct: 92 QVGHHDIYETRQLLEGWAALHSSAERGDWDVAEALLEKMDDPSLPLEDFLRFDAEFHVVI 151 Query: 116 GKK 118 K Sbjct: 152 SKG 154 >1HXH-A nrPDB Length = 253 Score = 30.0 bits (66), Expect = 0.81, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 25/86 (29%), Gaps = 9/86 (10%) Query: 114 AVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQ 173 EV + L+ GA V D AA +G + + V+ + Sbjct: 14 GASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAELGERSM------FVRHDVSSEADW 67 Query: 174 GWTPLFHALAEGHGDAAVLLVEKYGA 199 L A + +LV G Sbjct: 68 ---TLVMAAVQRRLGTLNVLVNNAGI 90 Score = 28.5 bits (62), Expect = 2.6, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 29/86 (33%), Gaps = 13/86 (15%) Query: 44 VSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKI 103 S E+ LL + V D + +G +A +G + + + Sbjct: 15 ASGVGLEVVKLLLGEGAKVAFSDINEAAGQ---QLAAELGERSMFVR----------HDV 61 Query: 104 TNQGVTCLHLAVGKKWFEVSQFLIEN 129 +++ L +A ++ L+ N Sbjct: 62 SSEADWTLVMAAVQRRLGTLNVLVNN 87 >4CJ9-A nrPDB Length = 794 Score = 29.3 bits (64), Expect = 1.7, Method: Composition-based stats. Identities = 12/88 (13%), Positives = 37/88 (42%), Gaps = 2/88 (2%) Query: 78 IACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKD 137 IA + G + +K++ + L++ + +A + + ++E+G ++ + Sbjct: 618 IAGNGGGAQALKAVLEHE--ATLDERGFSRADIVRIAGNGGGAQALKAVLEHGPTLNERG 675 Query: 138 KFNQIPLHRAASVGSLKLIELLCGLGKS 165 + AA+ G + ++ + G + Sbjct: 676 FNLTDIVEMAANSGGAQALKAVLEHGPT 703 Score = 26.6 bits (57), Expect = 8.9, Method: Composition-based stats. Identities = 16/120 (13%), Positives = 46/120 (38%), Gaps = 3/120 (2%) Query: 78 IACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQFLIENGASVRIKD 137 +A + G + +K++ + LN+ + +A + + ++E+ A++ + Sbjct: 585 VAGNNGGAQALKAVLEHE--ATLNERGFSRADIVKIAGNGGGAQALKAVLEHEATLDERG 642 Query: 138 KFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKY 197 + A + G + ++ + G + +N + + A G A ++E Sbjct: 643 FSRADIVRIAGNGGGAQALKAVLEHGPT-LNERGFNLTDIVEMAANSGGAQALKAVLEHG 701 >1OH2-P nrPDB Length = 413 Score = 28.9 bits (63), Expect = 1.8, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 22/85 (25%), Gaps = 9/85 (10%) Query: 64 LDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVS 123 D+ D +G A + G V +L T L G EV Sbjct: 198 NDERKDSNGNLAKGDAANTG----VHALLGLHNDSFYGLRDGSSKTALLYGHGLG-AEVK 252 Query: 124 QF----LIENGASVRIKDKFNQIPL 144 + GA + PL Sbjct: 253 GIGSDGALRPGADTWRIASYGTTPL 277 >4DNA-A nrPDB Length = 463 Score = 28.9 bits (63), Expect = 2.2, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 35/86 (40%), Gaps = 11/86 (12%) Query: 21 LLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIAC 80 L++ +L + DQD R LH ++ + I E++ D G +A Sbjct: 198 LIYRGKEILSRFDQDMRRGLHAAMEEKGIRILC------EDIIQSVSADADGR---RVAT 248 Query: 81 SVGNLEVV--KSLYDRPLKPDLNKIT 104 ++ + E+V + + P+ N + Sbjct: 249 TMKHGEIVADQVMLALGRMPNTNGLG 274 >3RJ4-A nrPDB Length = 290 Score = 28.5 bits (62), Expect = 2.6, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 21/68 (30%), Gaps = 2/68 (2%) Query: 2 SNYPLHQACMENEFFKV--QELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKM 59 + L A E +V LL S + Q D + + +L+S Sbjct: 171 DDALLQGAAQGEEVSEVLHSHLLKSNALITNQPDWGSVEIAYHGAKMNREALLRYLVSFR 230 Query: 60 ENVNLDDY 67 E+ + Sbjct: 231 EHNEFHEQ 238 >4WVX-A nrPDB Length = 326 Score = 28.1 bits (61), Expect = 3.1, Method: Composition-based stats. Identities = 10/69 (14%), Positives = 21/69 (30%), Gaps = 1/69 (1%) Query: 6 LHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLD 65 + A + + +++ + QK+ I H E ++LL + Sbjct: 144 IKLASSKGRITEYEKMFFRAAARA-QKETGAVIITHTQEGTMGPEQAAYLLEHGADPKKI 202 Query: 66 DYPDDSGWT 74 G T Sbjct: 203 VIGHMCGNT 211 >4TWE-A nrPDB Length = 743 Score = 28.1 bits (61), Expect = 3.2, Method: Composition-based stats. Identities = 10/58 (17%), Positives = 25/58 (43%), Gaps = 1/58 (1%) Query: 42 WSVSFQAHEITSFLLSKMENVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPD 99 + EI ++ +++ + + + P H+A S + ++V+ L R P+ Sbjct: 38 LAPQDLDLEILETVMGQLDAHRIRENLRELSREP-HLASSPRDEDLVQLLLQRWKDPE 94 >2I3A-A nrPDB Length = 352 Score = 27.7 bits (60), Expect = 4.3, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 32/103 (31%), Gaps = 13/103 (12%) Query: 114 AVGKKWFEVSQFLIENGASVRIKDKFNQIPLHRAASVG-----SLKLIELLCGLGKSAVN 168 A G E+ + L+ + A + + L A S G + L Sbjct: 17 ASGYAGGEILRLLLGHPAYADGRLRIG--ALTAATSAGSTLGEHHPHLTPLAHRVVEPTE 74 Query: 169 WQDKQGWTPLFHALAEGHGDAA------VLLVEKYGAEYDLVD 205 G +F AL GH L+ GA++ L D Sbjct: 75 AAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTD 117 >6HRH-B nrPDB Length = 469 Score = 27.3 bits (59), Expect = 5.1, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 39/112 (34%), Gaps = 8/112 (7%) Query: 113 LAVGKKWFEVSQFLIENGA--SVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQ 170 A G + ++ +GA SVR+ L RA + +LL G + Sbjct: 295 YAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCP 354 Query: 171 DKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVD----NKGAKAEDVALNE 218 P+ A + LL+ K+G ++ +G + +A + Sbjct: 355 --SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSP 404 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.135 0.352 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 8,208,458 Number of Sequences: 36641 Number of extensions: 314318 Number of successful extensions: 2347 Number of sequences better than 10.0: 90 Number of HSP's better than 10.0 without gapping: 123 Number of HSP's successfully gapped in prelim test: 34 Number of HSP's that attempted gapping in prelim test: 816 Number of HSP's gapped (non-prelim): 516 length of query: 228 length of database: 10,336,785 effective HSP length: 94 effective length of query: 134 effective length of database: 6,892,531 effective search space: 923599154 effective search space used: 923599154 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 57 (26.5 bits)