BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P49915 (693 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2VXO-A nrPDB 1385 0.0 2VPI-A nrPDB 403 e-112 5TW7-A nrPDB 307 1e-83 2YWB-A nrPDB 303 2e-82 3TQI-A nrPDB 302 3e-82 1GPM-A nrPDB 298 5e-81 4WIM-A nrPDB 252 3e-67 2DPL-A nrPDB 164 9e-41 2LXN-A nrPDB 108 5e-24 1WL8-A nrPDB 105 7e-23 4WIN-A nrPDB 100 2e-21 2A9V-A nrPDB 84 2e-16 1QDL-B nrPDB 58 1e-08 3FIJ-A nrPDB 52 6e-07 1I7S-B nrPDB 49 6e-06 1O1Y-A nrPDB 47 3e-05 2E18-A nrPDB 43 6e-04 3N05-A nrPDB 40 0.004 4GUD-A nrPDB 38 0.014 2DER-A nrPDB 37 0.021 2YWJ-A nrPDB 36 0.067 5WP0-A nrPDB 35 0.088 5KHA-A nrPDB 35 0.094 1OX5-A nrPDB 33 0.34 3D54-D nrPDB 33 0.49 3A2K-A nrPDB 33 0.58 4F4H-A nrPDB 33 0.61 3L7N-A nrPDB 32 0.72 6DG3-A nrPDB 32 0.82 2PG3-A nrPDB 32 0.88 3R75-A nrPDB 32 0.94 2C5S-A nrPDB 32 0.98 4XFD-A nrPDB 32 1.0 4V6U-AA nrPDB 32 1.2 3BL5-A nrPDB 32 1.3 3Q4G-A nrPDB 32 1.3 5B4F-A nrPDB 31 1.5 3WO0-A nrPDB 31 2.2 3M3P-A nrPDB 31 2.3 3P52-A nrPDB 30 3.1 3KZ1-A nrPDB 30 3.5 4HCS-A nrPDB 30 4.6 1OBF-O nrPDB 29 5.8 4F5M-A nrPDB 29 5.9 2EB0-A nrPDB 29 6.4 2ID1-A nrPDB 29 8.6 >2VXO-A nrPDB Length = 697 Score = 1385 bits (3584), Expect = 0.0, Method: Compositional matrix adjust. Identities = 674/674 (100%), Positives = 674/674 (100%) Query: 20 GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPN 79 GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPN Sbjct: 24 GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPN 83 Query: 80 SVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL 139 SVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL Sbjct: 84 SVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL 143 Query: 140 FRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENG 199 FRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENG Sbjct: 144 FRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENG 203 Query: 200 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA 259 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA Sbjct: 204 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA 263 Query: 260 LNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTP 319 LNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTP Sbjct: 264 LNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTP 323 Query: 320 RKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASL 379 RKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASL Sbjct: 324 RKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASL 383 Query: 380 VASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFP 439 VASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFP Sbjct: 384 VASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFP 443 Query: 440 GPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM 499 GPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM Sbjct: 444 GPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM 503 Query: 500 QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNR 559 QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNR Sbjct: 504 QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNR 563 Query: 560 VVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLH 619 VVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLH Sbjct: 564 VVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLH 623 Query: 620 FDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM 679 FDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM Sbjct: 624 FDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM 683 Query: 680 YDLTSKPPGTTEWE 693 YDLTSKPPGTTEWE Sbjct: 684 YDLTSKPPGTTEWE 697 >2VPI-A nrPDB Length = 218 Score = 403 bits (1036), Expect = e-112, Method: Compositional matrix adjust. Identities = 195/195 (100%), Positives = 195/195 (100%) Query: 25 EGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAE 84 EGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAE Sbjct: 24 EGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAE 83 Query: 85 DAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQ 144 DAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQ Sbjct: 84 DAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQ 143 Query: 145 KEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILK 204 KEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILK Sbjct: 144 KEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILK 203 Query: 205 NFLYDIAGCSGTFTV 219 NFLYDIAGCSGTFTV Sbjct: 204 NFLYDIAGCSGTFTV 218 >5TW7-A nrPDB Length = 529 Score = 307 bits (786), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 207/557 (37%), Positives = 301/557 (54%), Gaps = 65/557 (11%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 ++ILD G+Q ++I RRVRE V E+ + P IK + II+SGGPNSVY D Sbjct: 14 ILILDFGSQVTRLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYESDYQ 73 Query: 88 WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEE 147 D IF +G PVLGICYGMQ M GG V + RE G + ++ L RG+Q + Sbjct: 74 -ADTGIFDLGIPVLGICYGMQFMAHHLGGEVQPGNQREFGYAQVKTIDS-GLTRGIQDDA 131 Query: 148 V----VLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVI 202 V ++HGD V K+ DGF V+ + + +A + N K+ YG QFHPEV T+ G+ + Sbjct: 132 PNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMENTEKQFYGIQFHPEVTHTKQGRAL 191 Query: 203 LKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQ 262 L F+ DI G +T+ N E + +I+E+VG+ +V++ LSGGVDS+V AL++RA+ Sbjct: 192 LNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRAIG- 250 Query: 263 EQVIAVHIDNGFMRKRESQSVEEAL-KKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRK 321 +Q+ V +D+G +R E + V + + LG++V ++A F Sbjct: 251 DQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQFM----------------- 293 Query: 322 RISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVA 381 L T PE+KRKIIG F+++ + E +LAQGT+ PD+IESA Sbjct: 294 ---AKLAGVTDPEKKRKIIGAEFIEVFD---AEEKKLTNAKWLAQGTIYPDVIESAG-AK 346 Query: 382 SGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGP 441 + KA IK+HHN L ++ K++EPL+D KDEVR LG LGLP E+V RHPFPGP Sbjct: 347 TKKAHAIKSHHNVGGLPENMKL--KLLEPLRDLFKDEVRELGVALGLPREMVYRHPFPGP 404 Query: 442 GLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQI 501 GL +R++ + E ++L+ D +Q ++ TT+E+ + Sbjct: 405 GLGVRILGEVK-------KEYADLLRQADDI---------FIQELRN-TTDENGTSWYDL 447 Query: 502 TSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPD-----WESLIF--LARLIPRMC 554 TS A LP+K+VGV GD R+Y YV + + D W L + L R+ R+ Sbjct: 448 TS--QAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAHWAELPYSLLGRVSNRII 505 Query: 555 HNV---NRVVY-IFGPP 567 + V NRVVY + G P Sbjct: 506 NEVKGINRVVYDVSGKP 522 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 25/60 (41%), Positives = 38/60 (63%), Gaps = 5/60 (8%) Query: 635 VVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 V +R ITSDFMT A E+P ++ ++ I ++ GI+R++YD++ KPP T EWE Sbjct: 474 VALRAVITSDFMTAHWA----ELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE 529 >2YWB-A nrPDB Length = 503 Score = 303 bits (775), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 209/546 (38%), Positives = 293/546 (53%), Gaps = 68/546 (12%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 V++LD G+QY ++I RR+REL S I P + P + + +A+I+SGGP SV+ DAP Sbjct: 2 VLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDAP 61 Query: 88 WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEE 147 DP +F+ G P+LGICYGMQ++ + GG V + E G + + LFRGL+ E Sbjct: 62 RPDPRLFSSGLPLLGICYGMQLLAQELGGRVERAGRAEYGK-ALLTRHEGPLFRGLEGEV 120 Query: 148 VVLLTHGDSVDKVADGFKVVARS-GNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNF 206 V ++H D+V G++VVA + N VA IA+ + YG QFHPEV T G IL+NF Sbjct: 121 QVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFHPEVAHTPKGMQILENF 180 Query: 207 LYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVI 266 L ++AG +T ++ E +RE++ER G +VL+ +SGGVDS+ LL +A + Sbjct: 181 L-ELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDH--L 237 Query: 267 AVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKT 326 AV +D+G +R E + VE AL+ LG+ + V++A ++R K Sbjct: 238 AVFVDHGLLRLGEREEVEGALRALGVNLLVVDA--------------------KERFLKA 277 Query: 327 LNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAE 386 L PEEKRKIIG FV ++V E + FLAQGTL PD+IESA + K Sbjct: 278 LKGVEDPEEKRKIIGREFVAAFSQVARE---RGPFRFLAQGTLYPDVIESAGGHGAAK-- 332 Query: 387 LIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIR 446 IK+HHN L L E +++EP + KDEVR L LGLP+ L RHPFPGPGLA+R Sbjct: 333 -IKSHHNVGGLPEDL--EFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAVR 389 Query: 447 VICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHS 506 V + + E IL+ D S+ + L ++V Sbjct: 390 V-------LGEVTEERLEILRRADDIFTSLLREWGLYEKVAQAL---------------- 426 Query: 507 LNAFLLPIKTVGVQGDCRSYSYVC---GISSKD--EPDWESLI--FL---ARLIPRMCHN 556 A L P+++VGV GD R Y YV ++++D DW L FL AR I R Sbjct: 427 --AVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITRRVPE 484 Query: 557 VNRVVY 562 + RVVY Sbjct: 485 IGRVVY 490 Score = 61.2 bits (147), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/110 (35%), Positives = 58/110 (52%), Gaps = 6/110 (5%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSD 644 L LR+AD ++LRE G K++Q +LTP+ + + +R T D Sbjct: 399 LEILRRADDIFTSLLREWGLYEKVAQALAVLTPVR-SVGVAGDERKYGYVLALRAVTTED 457 Query: 645 FMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 FMT A +P+E + + I +++P I R++YDLTSKPP T EWE Sbjct: 458 FMTADWA----RLPLEFLDEAARRITRRVPEIGRVVYDLTSKPPATIEWE 503 >3TQI-A nrPDB Length = 527 Score = 302 bits (773), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 209/580 (36%), Positives = 304/580 (52%), Gaps = 81/580 (13%) Query: 17 LKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISG 76 LKD H H ++ILD G+QY ++I RRVRE+ V E+ P + I++ II+SG Sbjct: 5 LKDIHQH---RILILDFGSQYAQLIARRVREIGVYCELMPCDIDEETIRDFNPHGIILSG 61 Query: 77 GPNSV---YAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISV 133 GP +V + AP F IF IG PVLGICYGMQ M GG V++ + E G + V Sbjct: 62 GPETVTLSHTLRAPAF---IFEIGCPVLGICYGMQTMAYQLGGKVNRTAKAEFGHAQLRV 118 Query: 134 DNTCSLFRGLQKEEV--------VLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKL 184 N LF G++ + V ++HGD V ++ GF+ A + N +A +A+ ++ Sbjct: 119 LNPAFLFDGIEDQVSPQGEPLLDVWMSHGDIVSELPPGFEATACTDNSPLAAMADFKRRF 178 Query: 185 YGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLS 244 +G QFHPEV T G IL +F+ I C +T ++ + IR+I+E+VG +V+V LS Sbjct: 179 FGLQFHPEVTHTPQGHRILAHFVIHICQCIPNWTTKHIIEDSIRDIQEKVGKEQVIVGLS 238 Query: 245 GGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKK-LGIQVKVINAAHSF 303 GGVDS V L+++A+ +Q++ V +D G +R E V +K LG +V ++A Sbjct: 239 GGVDSAVTATLVHKAIG-DQLVCVLVDTGLLRLNEVDEVLNVFQKHLGAKVICVDA---- 293 Query: 304 YNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVF 363 + R K L + PEEKRKI G+ F+++ E ++N+K + Sbjct: 294 ----------------KDRFMKALKGISDPEEKRKIAGEQFIRVFEEQAKKLNVK----W 333 Query: 364 LAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILG 423 L QGT+ PD+IESA +GK +IKTHHN L L E K+IEPL++ KDEVR LG Sbjct: 334 LGQGTIYPDVIESAK-TKTGKGHIIKTHHNVGGL--PLNMELKLIEPLRELFKDEVRKLG 390 Query: 424 RELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIV-ADFSASVKKPHTL 482 ELGLP +L+ RHPFPGPGLAIR++ E NILK A F +KK Sbjct: 391 LELGLPADLIYRHPFPGPGLAIRILGEVSA-------EYINILKQADAIFIEELKKSDYY 443 Query: 483 LQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPD--- 539 Q +A A +P+K+VGV+GD R Y Y+ + + D Sbjct: 444 HQVSQAF-------------------AVFMPLKSVGVKGDARHYGYIIALRAVKTVDFMT 484 Query: 540 --WESLI--FLARLIPRMCHNVNRVVYIFGPPVKEPPTDV 575 W L FL+++ R+ + + V + +PP + Sbjct: 485 AQWADLPHEFLSKVSHRIVNEIKEVSRVVYDMTNKPPATI 524 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 8/111 (7%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVI--RTFIT 642 ++ L+QAD L++S Y ++SQ + PL + K + +I R T Sbjct: 423 INILKQADAIFIEELKKSDYYHQVSQAFAVFMPL---KSVGVKGDARHYGYIIALRAVKT 479 Query: 643 SDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE 693 DFMT A +E +V ++V EIK++ SR++YD+T+KPP T EWE Sbjct: 480 VDFMTAQWADLPHEFLSKVSHRIVNEIKEV---SRVVYDMTNKPPATIEWE 527 >1GPM-A nrPDB Length = 525 Score = 298 bits (763), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 208/562 (37%), Positives = 294/562 (52%), Gaps = 75/562 (13%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 ++ILD G+QY +++ RRVREL V E++ + I++ II+SGGP S E++P Sbjct: 10 ILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSP 69 Query: 88 WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEE 147 +F G PV G+CYGMQ M GG V + RE G + V N +L RG++ Sbjct: 70 RAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDAL 129 Query: 148 V--------VLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTEN 198 V ++HGD V + F VA + + A +ANE K+ YG QFHPEV T Sbjct: 130 TADGKPLLDVWMSHGDKVTAIPSDFITVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQ 189 Query: 199 GKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNR 258 G +L+ F+ DI C +T + + I+E+VG KV++ LSGGVDS+V LL+R Sbjct: 190 GMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHR 249 Query: 259 ALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRT 318 A+ + + V +DNG +R E+ E+ L G +N H +P D Sbjct: 250 AIGK-NLTCVFVDNGLLRLNEA---EQVLDMFGDHFG-LNIVH--------VPAED---- 292 Query: 319 PRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEV-FLAQGTLRPDLIESA 377 R L PE KRKIIG FV EV E LK E+V +LAQGT+ PD+IESA Sbjct: 293 ---RFLSALAGENDPEAKRKIIGRVFV----EVFDEEALKLEDVKWLAQGTIYPDVIESA 345 Query: 378 SLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 + A+GKA +IK+HHN L ++++ ++EPLK+ KDEVR +G ELGLP +++ RHP Sbjct: 346 A-SATGKAHVIKSHHNVGGLPKEMKM--GLVEPLKELFKDEVRKIGLELGLPYDMLYRHP 402 Query: 438 FPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHT-LLQRVKACTTEEDQE 496 FPGPGL +RV+ VKK + LL+R A EE ++ Sbjct: 403 FPGPGLGVRVL-------------------------GEVKKEYCDLLRRADAIFIEELRK 437 Query: 497 KLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPD-----WESL--IFLARL 549 + + F LP+++VGV GD R Y +V + + + D W L FL R+ Sbjct: 438 ADLYDKVSQAFTVF-LPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRV 496 Query: 550 IPRMCHNVN---RVVY-IFGPP 567 R+ + VN RVVY I G P Sbjct: 497 SNRIINEVNGISRVVYDISGKP 518 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 6/107 (5%) Query: 588 LRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMT 647 LR+AD LR++ K+SQ + P+ + V +R T DFMT Sbjct: 424 LRRADAIFIEELRKADLYDKVSQAFTVFLPVR-SVGVMGDGRKYDWVVSLRAVETIDFMT 482 Query: 648 GIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 A +P + + ++ I ++ GISR++YD++ KPP T EWE Sbjct: 483 AHWA----HLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE 525 >4WIM-A nrPDB Length = 568 Score = 252 bits (644), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 183/608 (30%), Positives = 289/608 (47%), Gaps = 100/608 (16%) Query: 15 GDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIII 74 G + +G + +++L+ G+QY +I +R+ + + SE IK+ + +I+ Sbjct: 11 GSMAEGEEY--DKILVLNFGSQYFHLIVKRLNNIKIFSETKDYGVELKDIKDMNIKGVIL 68 Query: 75 SGGPNSVYAEDAPWFDPAIFTI----GKPVLGICYGMQMMNKVFGGTVHKKS-------- 122 SGGP SV +P +F P+ GICYGMQ + G V K Sbjct: 69 SGGPYSVTEAGSPHLKKEVFEYFLEKKIPIFGICYGMQEIAVQMNGEVKKSKTSEYGCTD 128 Query: 123 ---VREDGVFNIS--------------------VDNTCSLFRGLQKE-EVVLLTHGDSVD 158 +R D + NI+ ++ TC LF ++ + V + H D V Sbjct: 129 VNILRNDNINNITYCRNFGDSSSAMDLYSNYKLMNETCCLFENIKSDITTVWMNHNDEVT 188 Query: 159 KVADGFKVVARSGN-IVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTF 217 K+ + F +V+ S N ++ I N+ +YG Q+HPEV + +G+++ NF Y+I C F Sbjct: 189 KIPENFYLVSSSENCLICSIYNKEYNIYGVQYHPEVYESLDGELMFYNFAYNICKCKKQF 248 Query: 218 T-VQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMR 276 ++ ELE ++ I++ V+ +SGG+DSTV A ++ +E+ + IDNG +R Sbjct: 249 DPIRYHELE-LKNIEKYKHDHYVIAAMSGGIDSTVAAAYTHKIF-KERFFGIFIDNGLLR 306 Query: 277 KRESQSVEEALKKL--GIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPE 334 K E+++V LK + + I+A+ +F + L T PE Sbjct: 307 KNEAENVYTFLKSTFPDMNITKIDASENFLSN--------------------LQGVTDPE 346 Query: 335 EKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHND 394 +KRKIIG F++ + + +++ + FL QGTL PD+IES + ++ IKTHHN Sbjct: 347 QKRKIIGKLFIEEFEKAVNNIDIDINKTFLLQGTLYPDIIESK--CSKNLSDTIKTHHNV 404 Query: 395 TELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPY 454 L + L+ K+ EP K KD+V+ L REL LPEE+ +RHPFPGPGLAIRVI + Sbjct: 405 GGLPKNLK--FKLFEPFKYLFKDDVKTLSRELNLPEEITNRHPFPGPGLAIRVIGEINKH 462 Query: 455 ICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPI 514 NIL+ V D + K + L ++ A LL Sbjct: 463 KL-------NILREVDDIFINDLKQYGLYNQISQAF------------------AVLLSS 497 Query: 515 KTVGVQGDCRSYSYVCGI-----SSKDEPDWESLIF--LARLIPRMCHNVNRVVYIFGPP 567 K+VGV+GD RSY YVC + SS +W + + L ++ R+ V V I Sbjct: 498 KSVGVRGDARSYDYVCVLRAVKTSSFMTANWYQIPYDILDKITTRILSEVKGVNRILYDV 557 Query: 568 VKEPPTDV 575 +PP + Sbjct: 558 SSKPPATI 565 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 37/113 (32%), Positives = 58/113 (51%), Gaps = 12/113 (10%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVIL---TPLHFDRDPLQKQPSCQRSVVIRTFI 641 L+ LR+ D N L++ G +ISQ +L + D C V+R Sbjct: 464 LNILREVDDIFINDLKQYGLYNQISQAFAVLLSSKSVGVRGDARSYDYVC----VLRAVK 519 Query: 642 TSDFMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 TS FMT +IP +++ K+ T I ++ G++RI+YD++SKPP T E+E Sbjct: 520 TSSFMTA----NWYQIPYDILDKITTRILSEVKGVNRILYDVSSKPPATIEFE 568 >2DPL-A nrPDB Length = 308 Score = 164 bits (416), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 123/351 (35%), Positives = 174/351 (49%), Gaps = 77/351 (21%) Query: 225 ECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVE 284 E +REI+E VG SK ++ LSGGVDS+ L ++A+ +++ AV ++ GF+RK E + V Sbjct: 9 EKVREIRETVGDSKAIIALSGGVDSSTAAVLAHKAIG-DRLHAVFVNTGFLRKGEPEFVV 67 Query: 285 EALK-KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDT 343 + + + G+ + ++A F++ L T PEEKRKIIG Sbjct: 68 KTFRDEFGMNLHYVDAQDRFFS--------------------ALKGVTDPEEKRKIIGRV 107 Query: 344 FVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLRE 403 F+++ EV ++ + +L QGT+ PD IES GK IK+HHN L KL Sbjct: 108 FIEVFEEVAKKIGAE----YLIQGTIAPDWIES-----QGK---IKSHHNVGGLPEKLNL 155 Query: 404 EGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETN 463 K+IEPL+D +KDEVR L + LGLPE++ +R PFPGPGLA+RVI P + E N Sbjct: 156 --KLIEPLRDLYKDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVREAN 213 Query: 464 NILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAF--LLPIKTVGVQG 521 I+ EE+ E+ L AF LL +KTVGVQG Sbjct: 214 AIV-------------------------EEEVER----AGLRPWQAFAVLLGVKTVGVQG 244 Query: 522 DCRSYSYVCGISSKDEPD----------WESLIFLARLIPRMCHNVNRVVY 562 D R+Y + + D WE L +A I V RV+Y Sbjct: 245 DIRAYKETIAVRIVESIDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY 295 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 39/65 (60%), Gaps = 5/65 (7%) Query: 630 SCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPG 688 + + ++ +R + D MT A N +P EV+ ++ I +IP + R++YD+T+KPP Sbjct: 248 AYKETIAVRIVESIDGMT---ANAMN-VPWEVLQRIAFRITSEIPEVGRVLYDITNKPPA 303 Query: 689 TTEWE 693 T E+E Sbjct: 304 TIEFE 308 >2LXN-A nrPDB Length = 188 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 68/181 (37%), Positives = 101/181 (55%), Gaps = 5/181 (2%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIK-EQGFRAIIISGGPNSVYAEDA 86 +VILD G QY I R ++ + V S+I P TP I+ + + II+SGGP+ A++ Sbjct: 2 IVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKNC 61 Query: 87 PWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKE 146 D A+ P+LGIC G Q++ +GG V + E + + VD LF+ + +E Sbjct: 62 --IDIAL-NAKLPILGICLGHQLIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPRE 118 Query: 147 EVVLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVILKN 205 +H D V KV +GF+++A S V + +++K +YG QFHPEV TE G ILKN Sbjct: 119 FNAWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGVQFHPEVAHTEYGNEILKN 178 Query: 206 F 206 F Sbjct: 179 F 179 >1WL8-A nrPDB Length = 189 Score = 105 bits (262), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 66/180 (36%), Positives = 95/180 (52%), Gaps = 1/180 (0%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 +VI+D G QY I R +R L V+++I P TP IK + II SGGP+ + Sbjct: 3 IVIMDNGGQYVHRIWRTLRYLGVETKIIPNTTPLEEIKAMNPKGIIFSGGPSLENTGNCE 62 Query: 88 WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEE 147 P+LGIC G Q++ K FGG V + E + I + + +F+GL K Sbjct: 63 KVLEHYDEFNVPILGICLGHQLIAKFFGGKVGRGEKAEYSLVEIEIIDENEIFKGLPKRL 122 Query: 148 VVLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVILKNF 206 V +H D V ++ FK++ARS + + +E +YG QFHPEV TE G+ IL+NF Sbjct: 123 KVWESHMDEVKELPPKFKILARSETCPIEAMKHEELPIYGVQFHPEVAHTEKGEEILRNF 182 >4WIN-A nrPDB Length = 249 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 110/240 (45%), Gaps = 39/240 (16%) Query: 15 GDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIII 74 G + +G + +++L+ G+QY +I +R+ + + SE IK+ + +I+ Sbjct: 10 GSMAEGEEY--DKILVLNFGSQYFHLIVKRLNNIKIFSETKDYGVELKDIKDMNIKGVIL 67 Query: 75 SGGPNSVYAEDAPWFDPAIFTI----GKPVLGICYGMQMMNKVFGGTVHKKS-------- 122 SGGP SV +P +F P+ GICYGMQ + G V K Sbjct: 68 SGGPYSVTEAGSPHLKKEVFEYFLEKKIPIFGICYGMQEIAVQMNGEVKKSKTSEYGCTD 127 Query: 123 ---VREDGVFNIS--------------------VDNTCSLFRGLQKE-EVVLLTHGDSVD 158 +R D + NI+ ++ TC LF ++ + V + H D V Sbjct: 128 VNILRNDNINNITYCRNFGDSSSAMDLYSNYKLMNETCCLFENIKSDITTVWMNHNDEVT 187 Query: 159 KVADGFKVVARSGN-IVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTF 217 K+ + F +V+ S N ++ I N+ +YG Q+HPEV + +G+++ NF Y+I C F Sbjct: 188 KIPENFYLVSSSENCLICSIYNKEYNIYGVQYHPEVYESLDGELMFYNFAYNICKCKKQF 247 >2A9V-A nrPDB Length = 212 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 98/209 (46%), Gaps = 24/209 (11%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 + ++D G Q+ R +REL V ++I P + + + G +++SGG AP Sbjct: 16 IYVVDNGGQWTHREWRVLRELGVDTKIVPNDIDSSEL--DGLDGLVLSGG--------AP 65 Query: 88 WFDPAIFTIGK----------PVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTC 137 D + +G P+LGIC G Q + FG +V K E G +SV ++ Sbjct: 66 NIDEELDKLGSVGKYIDDHNYPILGICVGAQFIALHFGASVVKAKHPEFGKTKVSVMHSE 125 Query: 138 SLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLT 196 ++F GL E V H D + + D F + A S V G ++++ +Y QFHPEV T Sbjct: 126 NIFGGLPSEITVWENHNDEIINLPDDFTLAASSATCQVQGFYHKTRPIYATQFHPEVEHT 185 Query: 197 ENGKVILKNFLYDIAGCSGTFTVQNRELE 225 + G+ I +NF I C+ +Q + Sbjct: 186 QYGRDIFRNF---IGICASYREIQKENFQ 211 >1QDL-B nrPDB Length = 195 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/144 (35%), Positives = 68/144 (47%), Gaps = 8/144 (5%) Query: 72 IIISGGPNSVYA-EDAPWFDPAIFTIGK--PVLGICYGMQMMNKVFGGTVHK-KSVREDG 127 +IIS GP + ED I +GK P+LG+C G Q + FG + + + V Sbjct: 49 LIISPGPGTPEKREDIGVSLDVIKYLGKRTPILGVCLGHQAIGYAFGAKIRRARKVFHGK 108 Query: 128 VFNISVDNTC--SLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSG--NIVAGIANESKK 183 + NI + N SL+ G+ KE H VD+V V A S N + I +E Sbjct: 109 ISNIILVNNSPLSLYYGIAKEFKATRYHSLVVDEVHRPLIVDAISAEDNEIMAIHHEEYP 168 Query: 184 LYGAQFHPEVGLTENGKVILKNFL 207 +YG QFHPE T G IL NFL Sbjct: 169 IYGVQFHPESVGTSLGYKILYNFL 192 >3FIJ-A nrPDB Length = 254 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 47/175 (26%), Positives = 77/175 (44%), Gaps = 36/175 (20%) Query: 55 FPLETPAFAIKEQGF-RAIIISGGPN---SVYAED-----APWFDP----------AIFT 95 P++ P+ A++ ++++GG + +Y E+ +F P A Sbjct: 47 LPIDDPSTAVQAISLVDGLLLTGGQDITPQLYLEEPSQEIGAYFPPRDSYEIALVRAALD 106 Query: 96 IGKPVLGICYGMQMMNKVFGGTV-------------HKKSVRED-GVFNISVDNTCSLFR 141 GKP+ IC GMQ++N GGT+ H + V E G I ++ T L + Sbjct: 107 AGKPIFAICRGMQLVNVALGGTLYQDISQVETKALQHLQRVDEQLGSHTIDIEPTSELAK 166 Query: 142 GLQKEEVVLLTHGDSVDKVADGFKVVARS--GNIVAGIANESKKLY-GAQFHPEV 193 +++V H + K+A FKV AR+ G I A + Y G Q+HPE+ Sbjct: 167 HHPNKKLVNSLHHQFIKKLAPSFKVTARTADGMIEAVEGDNLPSWYLGVQWHPEL 221 >1I7S-B nrPDB Length = 193 Score = 49.3 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 30/109 (27%), Positives = 51/109 (46%) Query: 99 PVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVD 158 P++GIC G Q + + +GG V + G + + +F G+ V H Sbjct: 79 PIIGICLGHQAIVEAYGGQVGQAGEILHGKASAIAHDGEGMFAGMANPLPVARYHSLVGS 138 Query: 159 KVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFL 207 + V AR G +V + ++ +++ G QFHPE LT +G +L+ L Sbjct: 139 NIPADLTVNARFGEMVMAVRDDRRRVCGFQFHPESILTTHGARLLEQTL 187 >1O1Y-A nrPDB Length = 239 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 10/134 (7%) Query: 69 FRAIIISGGPNSVYAEDAPWFDPAIFTIGK-------PVLGICYGMQMMNKVFGGTVHK- 120 + +++ GG Y E+ F F + + P LGIC G QM+ KV G +V++ Sbjct: 58 YSLVVLLGGYMGAYEEEKYPFLKYEFQLIEEILKKEIPFLGICLGSQMLAKVLGASVYRG 117 Query: 121 KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANE 180 K+ E G + + + FR V HGD+ D +V G Sbjct: 118 KNGEEIGWYFVEKVSDNKFFREFPDRLRVFQWHGDTFDLPRRATRVFTSEKYENQGFV-- 175 Query: 181 SKKLYGAQFHPEVG 194 K G QFH EVG Sbjct: 176 YGKAVGLQFHIEVG 189 >2E18-A nrPDB Length = 257 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 33/83 (39%), Positives = 46/83 (55%), Gaps = 12/83 (14%) Query: 219 VQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKR 278 V R LE IRE G + V++ +SGGVDS L +AL +E+V+ + M Sbjct: 9 VIERILEFIRE----KGNNGVVIGISGGVDSATVAYLATKALGKEKVLGL-----IMPYF 59 Query: 279 ESQSVEEA---LKKLGIQVKVIN 298 E++ VE+A +KLGI KVIN Sbjct: 60 ENKDVEDAKLVAEKLGIGYKVIN 82 >3N05-A nrPDB Length = 590 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 45/206 (21%), Positives = 83/206 (40%), Gaps = 16/206 (7%) Query: 150 LLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVI------- 202 L+ GDS+ DG +VVAR+ G L A+ P G+ ++G I Sbjct: 227 LVFDGDSIVVDRDG-EVVARAPQFSEGCVVLDLDLPAAEAEPPTGVVDDGLRIDRLVISE 285 Query: 203 --LKNFLYDIAGCSGTFTVQNRELEC-----IREIKERVGTSKVLVLLSGGVDSTVCTAL 255 L + ++AG + E+ +R + G VL+ LSGG+DS + A+ Sbjct: 286 EPLPAYEAELAGGYADRLDADEEVYSALVVGLRAYVAKNGFRSVLIGLSGGIDSALVAAI 345 Query: 256 LNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISD- 314 AL + V V + + + E ++ G+ + ++ F +L ++ Sbjct: 346 ACDALGAQNVYGVSMPSKYSSDHSKGDAAELARRTGLNFRTVSIEPMFDAYMASLGLTGL 405 Query: 315 EDRTPRKRISKTLNMTTSPEEKRKII 340 + + R+ T M S +E ++ Sbjct: 406 AEENLQSRLRGTTLMAISNQEGHIVL 431 >4GUD-A nrPDB Length = 211 Score = 38.1 bits (87), Expect = 0.014, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 72/191 (37%), Gaps = 54/191 (28%) Query: 62 FAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFT-------------------IGKPVLG 102 FAI+ G+ A+ IS P V A D F P + T + KP+LG Sbjct: 20 FAIERLGY-AVTISRDPQVVLAADK-LFLPGVGTASEAMKNLTERDLIELVKRVEKPLLG 77 Query: 103 ICYGMQMMNKVFGGTVHKKSVRED--------------------------GVFNISVDNT 136 IC GMQ++ K+ +K + D G + V Sbjct: 78 ICLGMQLLGKL----SEEKGQKADEIVQCLGLVDGEVRLLQTGDLPLPHMGWNTVQVKEG 133 Query: 137 CSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLT 196 LF G++ + H ++ V D G + A ++ YG QFHPE + Sbjct: 134 HPLFNGIEPDAYFYFVHSFAM-PVGDYTIAQCEYGQPFSA-AIQAGNYYGVQFHPERS-S 190 Query: 197 ENGKVILKNFL 207 + G +++NFL Sbjct: 191 KAGARLIQNFL 201 >2DER-A nrPDB Length = 380 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 90/211 (42%), Gaps = 50/211 (23%) Query: 238 KVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEE------------ 285 KV+V +SGGVDS+V LL Q+Q ++ FM+ E EE Sbjct: 19 KVIVGMSGGVDSSVSAWLL-----QQQ--GYQVEGLFMKNWEEDDGEEYCTAAADLADAQ 71 Query: 286 -ALKKLGIQVKVINAAHSFYNGTTTLPISD--EDRTPRKRISKTLNMTTSPEEKRKIIGD 342 KLGI++ +N A +++ L +++ RTP ++ + E K K Sbjct: 72 AVCDKLGIELHTVNFAAEYWDNVFELFLAEYKAGRTPNP------DILCNKEIKFK---- 121 Query: 343 TFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIK---THHNDTELIR 399 F++ A E +L + + R D+ GK+ L++ ++ + + + Sbjct: 122 AFLEFAAE-----DLGADYIATGHYVRRADV--------DGKSRLLRGLDSNKDQSYFLY 168 Query: 400 KLREE--GKVIEPLKDFHKDEVRILGRELGL 428 L E + + P+ + K +VR + +LGL Sbjct: 169 TLSHEQIAQSLFPVGELEKPQVRKIAEDLGL 199 >2YWJ-A nrPDB Length = 186 Score = 35.8 bits (81), Expect = 0.067, Method: Compositional matrix adjust. Identities = 42/155 (27%), Positives = 71/155 (45%), Gaps = 24/155 (15%) Query: 67 QGFRAIIISGGPNSVYAEDAPWFD--PAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVR 124 +G A+II GG ++ + + I P+LG C GM +++K GT + + Sbjct: 36 EGIDALIIPGGESTAIGKLMKKYGLLEKIKNSNLPILGTCAGMVLLSK---GTGINQILL 92 Query: 125 EDGVFNISVDNTCS-----------LFRGLQKEEVVLLTHGDSVDKV-ADGFKVVARSGN 172 E + +I+V F+ L K V + VDK+ +D +V+AR G+ Sbjct: 93 E--LMDITVKRNAYGRQVDSFEKEIEFKDLGKVYGVFI-RAPVVDKILSDDVEVIARDGD 149 Query: 173 IVAGIANESKKLYGAQFHPEVGLTENGKVILKNFL 207 + G+ + K FHPE L+E+G + K F+ Sbjct: 150 KIVGV--KQGKYMALSFHPE--LSEDGYKVYKYFV 180 >5WP0-A nrPDB Length = 279 Score = 35.4 bits (80), Expect = 0.088, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 88/228 (38%), Gaps = 40/228 (17%) Query: 224 LECIREIKERV---------GTSKVLVL-LSGGVDSTVCTALLNRALNQEQVIAVHIDNG 273 ++ + EIK+RV K L+L +SGGVDST C L A+N+ + D Sbjct: 18 IDPVEEIKKRVDFIKGKLLEAHCKSLILGISGGVDSTTCGRLAQLAVNELNLETQSSDYQ 77 Query: 274 FMRKRESQSVEEALKKLGIQVKVINAAHSFY----NGTTTLPISDEDRTPRKRISKTLNM 329 F+ R +++ + + ++ I HS NG L ++ + Sbjct: 78 FIAVRLPYGIQQDEDEAQLALQFIQPTHSISINIKNGVDGLHSANH--------IALKDT 129 Query: 330 TTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIK 389 P + KI FVK N+K +AQ E A V Sbjct: 130 GLLPTDSAKI---DFVK--------GNVKARARMIAQ-------YEVAGYVGGLVLGTDH 171 Query: 390 THHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 + N T K + + PL +K +VR + +LG PE+LV + P Sbjct: 172 SAENITGFYTKFGDGACDLAPLFGLNKRQVREVAAQLGAPEQLVKKVP 219 >5KHA-A nrPDB Length = 549 Score = 35.4 bits (80), Expect = 0.094, Method: Compositional matrix adjust. Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 1/80 (1%) Query: 226 CIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEE 285 R+ ER G V++ LSGG+DS + A+ A+ E+V AV + + + + E Sbjct: 278 ATRDYVERSGFPGVILGLSGGIDSALTLAIAVDAIGAERVQAVMMPYTYTSQISVEDAAE 337 Query: 286 ALKKLGIQVKVINAAHSFYN 305 +++G+ I HS N Sbjct: 338 QARRMGVTFG-IAEIHSIVN 356 >1OX5-A nrPDB Length = 555 Score = 33.5 bits (75), Expect = 0.34, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 66/157 (42%), Gaps = 35/157 (22%) Query: 97 GKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVD----------------NTC--- 137 GKP++GIC G+Q + F G+V +S + G+ I N+C Sbjct: 79 GKPIMGICVGLQAL---FAGSV--ESPKSTGLNYIDFKLSRFDDSEKPVPEIGWNSCIPS 133 Query: 138 -SLFRGLQKEEVVLLTHGDSV--------DKVADGFKVV-ARSGNIVAGIANESKKLYGA 187 +LF GL + H + + DG+K+ A+ G+ A ++ Sbjct: 134 ENLFFGLDPYKRYYFVHSFAAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFAT 193 Query: 188 QFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNREL 224 QFHPE + G +++NFL + ++ + +EL Sbjct: 194 QFHPEKS-GKAGLNVIENFLKQQSPPIPNYSAEEKEL 229 >3D54-D nrPDB Length = 213 Score = 32.7 bits (73), Expect = 0.49, Method: Compositional matrix adjust. Identities = 47/171 (27%), Positives = 74/171 (43%), Gaps = 36/171 (21%) Query: 69 FRAIIISGG--------PNSVYAEDAPWFDPA-IFTIGKPVLGICYGMQM---MNKVFGG 116 + II+ GG P +V A + F+ A GK ++GIC G Q+ M + G Sbjct: 42 YELIILPGGFSYGDYLRPGAVAAREKIAFEIAKAAERGKLIMGICNGFQILIEMGLLKGA 101 Query: 117 TVHKKSVREDGVF-----NISVDNTCSLF-RGLQKEEVVLL--THG-------DSVDKVA 161 + S G F ++ V+N + F +K E + + HG D V+ V Sbjct: 102 LLQNSS----GKFICKWVDLIVENNDTPFTNAFEKGEKIRIPIAHGFGRYVKIDDVNVVL 157 Query: 162 DGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLT-----ENGKVILKNFL 207 K V S +AG+ NES ++G HPE + E+GK + ++ L Sbjct: 158 RYVKDVNGSDERIAGVLNESGNVFGLMPHPERAVEELIGGEDGKKVFQSIL 208 >3A2K-A nrPDB Length = 464 Score = 32.7 bits (73), Expect = 0.58, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 40/66 (60%), Gaps = 9/66 (13%) Query: 237 SKVLVLLSGGVDSTVCTALLNRALN-----QEQVIAVHIDNGFMRKRESQSVEEALKKLG 291 + V+V +SGG DS ALL+ L+ + QVIA H+D+ F R RES+ E +K+ Sbjct: 19 AAVIVGVSGGPDSL---ALLHVFLSLRDEWKLQVIAAHVDHMF-RGRESEEEMEFVKRFC 74 Query: 292 IQVKVI 297 ++ +++ Sbjct: 75 VERRIL 80 >4F4H-A nrPDB Length = 565 Score = 32.7 bits (73), Expect = 0.61, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 38/77 (49%) Query: 227 IREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEA 286 +R+ + G ++ LSGGVDS + A+ AL E+V AV + + + + + Sbjct: 291 VRDYIGKNGFPGAIIGLSGGVDSALVLAVAVDALGAERVRAVMMPSRYTAGISTTDAADM 350 Query: 287 LKKLGIQVKVINAAHSF 303 +++G++ I A F Sbjct: 351 ARRVGVRYDEIAIAPMF 367 >3L7N-A nrPDB Length = 236 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 35/137 (25%), Positives = 57/137 (41%), Gaps = 14/137 (10%) Query: 69 FRAIIISGGPNSVYA--EDAPWFDPA--IFTIGKP------VLGICYGMQMMNKVFGGTV 118 F +I+ GGP S + ++ P++D + I K ++G+C G Q+M +G Sbjct: 46 FDMLILMGGPQSPSSTKKEFPYYDAQAEVKLIQKAAKSEKIIVGVCLGAQLMGVAYGADY 105 Query: 119 HKKSVREDGVFNISVDNTC---SLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVA 175 +E G + IS+ S + +V HGD + + D +V+A S Sbjct: 106 LHSPKKEIGNYLISLTEAGKMDSYLSDFSDDLLVGHWHGD-MPGLPDKAQVLAISQGCPR 164 Query: 176 GIANESKKLYGAQFHPE 192 I K Y Q H E Sbjct: 165 QIIKFGPKQYAFQCHLE 181 >6DG3-A nrPDB Length = 286 Score = 32.0 bits (71), Expect = 0.82, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 81/232 (34%), Gaps = 62/232 (26%) Query: 238 KVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVI 297 +V V SGG+DST+ + L ++ V AV ++ E ++LG V+ Sbjct: 20 RVTVAFSGGIDSTLVLKMALDVLGRDNVTAVVANSELFTDEEFDKAMSLAEELGANVQ-- 77 Query: 298 NAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNL 357 GTT +SD+ I N Sbjct: 78 --------GTTLDYLSDD------------------------------HIKNNT------ 93 Query: 358 KPEEVFLAQGTLRPDLIESASLVASGKA--ELIKTHHNDTELIRKLREEGKVIEPLK--D 413 P+ + A+ L + A+ S +IK ND K R E L+ D Sbjct: 94 -PDSWYYAKKMFYSRLNDIAANNGSAAVLDGMIKNDENDYRPGLKARSEAGARSLLQEAD 152 Query: 414 FHKDEVRILGRELGLPE-------ELVSRHPFPGPGLA---IRVICAEEPYI 455 F K +VR L +ELGL + SR P+ G L I + A E Y+ Sbjct: 153 FFKTDVRALAQELGLTNWNKVASCSVSSRFPY-GTTLTHDNIAQVMAAEKYL 203 >2PG3-A nrPDB Length = 232 Score = 32.0 bits (71), Expect = 0.88, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 41/88 (46%), Gaps = 8/88 (9%) Query: 235 GTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLG--- 291 G + +V+ SGG DST C L+ + + V + D G + E + +E +KLG Sbjct: 1 GMKRAVVVFSGGQDSTTC--LIQALQDYDDVHCITFDYGQRHRAEIEVAQELSQKLGAAA 58 Query: 292 ---IQVKVINAAHSFYNGTTTLPISDED 316 + V ++N + ++P+ D D Sbjct: 59 HKVLDVGLLNELATSSLTRDSIPVPDYD 86 >3R75-A nrPDB Length = 645 Score = 32.0 bits (71), Expect = 0.94, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 28/191 (14%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 +I+DA + +I +++ L + +E+ + A+ + +++ GP P Sbjct: 449 ALIVDAEDHFTAMIAQQLSSLGLATEVCGVHD---AVDLARYDVVVMGPGPGDPSDAGDP 505 Query: 88 -------WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLF 140 W I GKP + +C Q++N + G + ++ V G+ + +D LF Sbjct: 506 RIARLYAWLRHLIDE-GKPFMAVCLSHQILNAILGIPLVRREVPNQGI-QVEID----LF 559 Query: 141 RGLQKEEV------VLLTHGDSVDKVADGFKVVARSGNIVAG--IANESKKLYGAQFHPE 192 Q+E V V T D +D DG VA S + G A QFH E Sbjct: 560 G--QRERVGFYNTYVAQTVRDEMD--VDGVGTVAISRDPRTGEVHALRGPTFSSMQFHAE 615 Query: 193 VGLTENGKVIL 203 LT +G IL Sbjct: 616 SVLTVDGPRIL 626 >2C5S-A nrPDB Length = 413 Score = 32.0 bits (71), Expect = 0.98, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 13/95 (13%) Query: 238 KVLVLLSGGVDSTVCTAL-LNRALNQEQVIAVHIDN-GFMRKRESQSVEEALKKLGIQVK 295 KV+VLLSGG+DS V L + R ++ E AVH + F +R Q V + ++L K Sbjct: 189 KVMVLLSGGIDSPVAAYLTMKRGVSVE---AVHFHSPPFTSERAKQKVIDLAQELTKYCK 245 Query: 296 VINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMT 330 + +P ++ +T K I + +MT Sbjct: 246 RVTLH--------LVPFTEVQKTINKEIPSSYSMT 272 >4XFD-A nrPDB Length = 283 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 47/221 (21%), Positives = 88/221 (39%), Gaps = 38/221 (17%) Query: 222 RELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQ 281 R + I++ + G +++ +SGGVDS L RA+ Q +R+ Q Sbjct: 38 RRIAFIQQCLKDSGLKTLVLGISGGVDSLTAGLLAQRAVEQ------------LRE---Q 82 Query: 282 SVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIG 341 + ++A + + ++ LP + + S L + EE+ IG Sbjct: 83 TGDQAYRFIAVR----------------LPYQVQQDEADAQAS--LATIRADEEQTVNIG 124 Query: 342 DTFVKIANEVIGEMNLKPEEVFLAQGTL--RPDLIESASLVASGKAELIKTHHNDTELI- 398 + +A ++ L+P + G + R ++ ++ + +I T H ++ Sbjct: 125 PSVKALAEQLEALEGLEPAKSDFVIGNIKARIRMVAQYAIAGARGGLVIGTDHAAEAVMG 184 Query: 399 --RKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 K + + PL K +VR L R LG PE LV + P Sbjct: 185 FFTKFGDGACDLAPLSGLAKHQVRALARALGAPENLVEKIP 225 >4V6U-AA nrPDB Length = 198 Score = 31.6 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 15/95 (15%) Query: 106 GMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL--------FRGLQ--KEEVVLLTHGD 155 GM++ V +K+ R DG+FNI+ + L R +Q +E + + Sbjct: 84 GMKLARSYIRSLVRRKTTRIDGIFNITTKDGYKLRVMAMAIAMRRIQTSQERAIRKIMQE 143 Query: 156 SVDKVAD-----GFKVVARSGNIVAGIANESKKLY 185 + K A+ F + + +G I A IA E+KK+Y Sbjct: 144 IIYKKAEELNFKDFVLESVNGKIAAEIAKEAKKIY 178 >3BL5-A nrPDB Length = 219 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 34/66 (51%), Gaps = 8/66 (12%) Query: 238 KVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEA---LKKLGIQV 294 K +V+ SGG DST C + + + + H + +R SQ VE A +KLG++ Sbjct: 5 KAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYN-----QRHSQEVEVAKSIAEKLGVKN 59 Query: 295 KVINAA 300 +++ + Sbjct: 60 HLLDMS 65 >3Q4G-A nrPDB Length = 279 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 90/234 (38%), Gaps = 49/234 (20%) Query: 217 FTVQNRELECIREIKERVGTSKVLVL-LSGGVDSTVCTALLNRA---LNQE------QVI 266 F ++ R R++ E K LVL +SGGVDST C L A LNQ+ Q I Sbjct: 22 FEIERRVAFIKRKLTE--ARYKSLVLGISGGVDSTTCGRLAQLAVEELNQQHNTTEYQFI 79 Query: 267 AVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDE---DRTPRKRI 323 AV + G E + +EA A SF T ++ ++ + D Sbjct: 80 AVRLPYG-----EQKDEDEA-----------QLALSFIRPTHSVSVNIKAGVDGLHAASH 123 Query: 324 SKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASG 383 N P + K+ F+K N+K +AQ E A V Sbjct: 124 HALANTGLIPSDPAKV---DFIK--------GNVKARARMVAQ-------YEIAGYVGGL 165 Query: 384 KAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 + N T K + + PL +K +VR+L + LG PE+LV + P Sbjct: 166 VLGTDHSAENITGFYTKFGDGACDLAPLFGLNKRQVRLLAKTLGAPEQLVYKTP 219 >5B4F-A nrPDB Length = 329 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 57/138 (41%), Gaps = 15/138 (10%) Query: 238 KVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGF--MRKRESQSVEEALKKLGIQVK 295 +VLV +SGG DS +L+R Q + +HI+ G KR + + ++ G+++ Sbjct: 49 RVLVAVSGGKDSLALWDVLSRL--GYQAVGLHIELGIGEYSKRSLEVTQAFARERGLELL 106 Query: 296 VINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGE- 354 V++ ++ G L R+S + + KR II V+ V+ Sbjct: 107 VVDLKEAYGFGVPELA----------RLSGRVACSACGLSKRYIINQVAVEEGFRVVATG 156 Query: 355 MNLKPEEVFLAQGTLRPD 372 NL E L L P Sbjct: 157 HNLDDEAAVLFGNLLNPQ 174 >3WO0-A nrPDB Length = 470 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 5/75 (6%) Query: 310 LPISDEDRTPRKRISKTLNMTTS---PEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQ 366 PI+ D+TP+ ++T ++T S E K+KI+ K ANE +G N Sbjct: 260 FPIAIHDKTPQIGFTETSHITPSILDEEAKKKIV--EAAKKANEGLGLQNCATHTEIKLM 317 Query: 367 GTLRPDLIESASLVA 381 P LIESA+ A Sbjct: 318 KNREPGLIESAARFA 332 >3M3P-A nrPDB Length = 250 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 27/55 (49%), Gaps = 9/55 (16%) Query: 71 AIIISGGPNSVYAEDAPWFDPAIFTIGK-------PVLGICYGMQMMNKVFGGTV 118 + + GGP S +D PW P + + + PV+G C G Q++ K GG V Sbjct: 51 GLAMMGGPMSA-NDDLPWM-PTLLALIRDAVAQRVPVIGHCLGGQLLAKAMGGEV 103 >3P52-A nrPDB Length = 249 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 42/74 (56%), Gaps = 10/74 (13%) Query: 230 IKERVGTSK---VLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEA 286 I+E+V S+ V++ LSGG+DS + L RAL +E V A+ + K ++E+A Sbjct: 17 IQEKVKNSQSQGVVLGLSGGIDSALVATLCKRAL-KENVFALLMPTQISNK---ANLEDA 72 Query: 287 LK---KLGIQVKVI 297 L+ L ++ K+I Sbjct: 73 LRLCADLNLEYKII 86 >3KZ1-A nrPDB Length = 383 Score = 30.0 bits (66), Expect = 3.5, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 47/88 (53%), Gaps = 5/88 (5%) Query: 329 MTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLI--ESASLVASGKAE 386 +T +++++I + FV A+ + L+ ++ Q + +L+ E + + E Sbjct: 20 LTQREIDRQEVINELFVTEASHL---RTLRVLDLIFYQRMKKENLMPREELARLFPNLPE 76 Query: 387 LIKTHHNDTELIRKLREEGKVIEPLKDF 414 LI+ H++ E ++KLREEG +I+ + D Sbjct: 77 LIEIHNSWCEAMKKLREEGPIIKEISDL 104 >4HCS-A nrPDB Length = 81 Score = 29.6 bits (65), Expect = 4.6, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 4/39 (10%) Query: 441 PGLAIRVICAEEPYI----CKDFPETNNILKIVADFSAS 475 PG+ +V+ +EP C + P+TNN LK V AS Sbjct: 12 PGVCFKVLTTKEPKANIKRCYNLPKTNNCLKCVLFVDAS 50 >1OBF-O nrPDB Length = 335 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 60/144 (41%), Gaps = 13/144 (9%) Query: 213 CSGTFTVQNRELECIREIKERVGTSKVLVLLSGG--VDSTVCTALLNRALNQEQVIAVHI 270 C+G FT + + I+ G KV++ GG VD+TV + + L + I Sbjct: 98 CTGFFTTKEKAGAHIKG-----GAKKVIISAPGGADVDATVVYGVNHGTLKSTDTV---I 149 Query: 271 DNGFMRKRESQSVEEALK-KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNM 329 N + + L KLG+Q ++ H++ N + ED R+ S T++M Sbjct: 150 SNASCTTNCLAPLVKPLNDKLGLQDGLMTTVHAYTNNQVLTDVYHEDL--RRARSATMSM 207 Query: 330 TTSPEEKRKIIGDTFVKIANEVIG 353 + +GD ++ ++ G Sbjct: 208 IPTKTGAAAAVGDVLPELDGKLNG 231 >4F5M-A nrPDB Length = 406 Score = 29.3 bits (64), Expect = 5.9, Method: Compositional matrix adjust. Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 1/57 (1%) Query: 107 MQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADG 163 +Q M ++F T+ +K D F I + S F GL KE+V+ L V VA G Sbjct: 328 IQRMRQLFVNTLQEKGANRDFSFIIKQNGMFS-FSGLTKEQVLRLREEFGVYAVASG 383 >2EB0-A nrPDB Length = 307 Score = 29.3 bits (64), Expect = 6.4, Method: Compositional matrix adjust. Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 6/65 (9%) Query: 352 IGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPL 411 +G++N + E V G + P+LIES A GK ++ H ++ L EEGK+I + Sbjct: 32 LGDINPETEFVLRKFGVMEPELIES----AKGKEIILVDHSEKSQSFDDL-EEGKLI-AI 85 Query: 412 KDFHK 416 D HK Sbjct: 86 IDHHK 90 >2ID1-A nrPDB Length = 130 Score = 28.9 bits (63), Expect = 8.6, Method: Composition-based stats. Identities = 17/56 (30%), Positives = 29/56 (51%) Query: 9 KLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAI 64 KL+ AG D+ H G V++DAG V+ VR+ + ++ + P+FA+ Sbjct: 58 KLKEAGVDIVGSEGHESGEWVLVDAGDVVVHVMLPAVRDYYDIEALWGGQKPSFAV 113 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2VXO-A nrPDB 960 0.0 3TQI-A nrPDB 666 0.0 1GPM-A nrPDB 661 0.0 5TW7-A nrPDB 660 0.0 4WIM-A nrPDB 632 0.0 2YWB-A nrPDB 615 e-176 2DPL-A nrPDB 335 4e-92 2VPI-A nrPDB 274 8e-74 4WIN-A nrPDB 254 9e-68 1WL8-A nrPDB 244 1e-64 2A9V-A nrPDB 233 3e-61 2LXN-A nrPDB 230 1e-60 1QDL-B nrPDB 159 5e-39 1I7S-B nrPDB 156 2e-38 1O1Y-A nrPDB 128 8e-30 3FIJ-A nrPDB 121 1e-27 2E18-A nrPDB 77 3e-14 Sequences not found previously or not previously below threshold: 1C30-B nrPDB 86 6e-17 3R75-A nrPDB 68 1e-11 3L7N-A nrPDB 65 9e-11 3M3P-A nrPDB 63 6e-10 4GUD-A nrPDB 61 2e-09 1OX5-A nrPDB 54 2e-07 1XNG-A nrPDB 52 8e-07 4XFD-A nrPDB 50 3e-06 2YWJ-A nrPDB 49 7e-06 5WP0-A nrPDB 49 8e-06 5KHA-A nrPDB 49 9e-06 3Q4G-A nrPDB 48 1e-05 3P52-A nrPDB 48 1e-05 3N05-A nrPDB 47 3e-05 1NSY-A nrPDB 46 4e-05 4F4H-A nrPDB 45 1e-04 3NVA-A nrPDB 42 0.001 1L9X-A nrPDB 41 0.001 5MKQ-A nrPDB 41 0.002 3D54-D nrPDB 41 0.002 2H2W-A nrPDB 41 0.002 5U6R-A nrPDB 41 0.002 6DG3-A nrPDB 41 0.002 2NV0-A nrPDB 41 0.002 2W7T-A nrPDB 41 0.002 3DPI-A nrPDB 40 0.003 2HMA-A nrPDB 40 0.003 5B4F-A nrPDB 39 0.006 1Q7R-A nrPDB 39 0.009 5HUH-A nrPDB 39 0.010 5U03-A nrPDB 39 0.010 4XFJ-A nrPDB 38 0.013 3L18-A nrPDB 38 0.015 1VCN-A nrPDB 38 0.015 3FIU-A nrPDB 38 0.017 4ZDJ-A nrPDB 37 0.020 2DER-A nrPDB 37 0.022 1OI4-A nrPDB 37 0.037 2VDJ-A nrPDB 36 0.040 2VKT-A nrPDB 36 0.054 2PZ8-A nrPDB 36 0.064 2VRN-A nrPDB 36 0.067 4L8Y-C nrPDB 36 0.067 1JGT-A nrPDB 35 0.13 1KA9-H nrPDB 35 0.15 4WXY-B nrPDB 34 0.16 1K9V-F nrPDB 34 0.16 2PG3-A nrPDB 34 0.17 2ISS-D nrPDB 34 0.22 4OFW-A nrPDB 34 0.26 3A2K-A nrPDB 33 0.51 1Q19-A nrPDB 32 0.71 2E21-A nrPDB 32 0.72 1G2I-A nrPDB 32 0.93 2VJT-B nrPDB 32 1.2 6C8Q-A nrPDB 32 1.2 6NPU-A nrPDB 31 1.3 4XEY-B nrPDB 31 1.3 6FYQ-A nrPDB 31 1.4 2FO0-A nrPDB 31 1.5 3BL5-A nrPDB 31 1.5 2YAX-A nrPDB 31 1.6 2C5S-A nrPDB 31 1.7 2D1S-A nrPDB 31 1.9 2GRE-A nrPDB 31 2.1 2QYG-A nrPDB 31 2.7 3SEZ-A nrPDB 30 2.9 3F4N-A nrPDB 30 3.2 5W1A-B nrPDB 30 4.4 3F7A-A nrPDB 29 7.2 >2VXO-A nrPDB Length = 697 Score = 960 bits (2480), Expect = 0.0, Method: Composition-based stats. Identities = 674/674 (100%), Positives = 674/674 (100%) Query: 20 GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPN 79 GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPN Sbjct: 24 GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPN 83 Query: 80 SVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL 139 SVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL Sbjct: 84 SVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL 143 Query: 140 FRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENG 199 FRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENG Sbjct: 144 FRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENG 203 Query: 200 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA 259 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA Sbjct: 204 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA 263 Query: 260 LNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTP 319 LNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTP Sbjct: 264 LNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTP 323 Query: 320 RKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASL 379 RKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASL Sbjct: 324 RKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASL 383 Query: 380 VASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFP 439 VASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFP Sbjct: 384 VASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFP 443 Query: 440 GPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM 499 GPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM Sbjct: 444 GPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLM 503 Query: 500 QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNR 559 QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNR Sbjct: 504 QITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNR 563 Query: 560 VVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLH 619 VVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLH Sbjct: 564 VVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLH 623 Query: 620 FDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM 679 FDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM Sbjct: 624 FDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIM 683 Query: 680 YDLTSKPPGTTEWE 693 YDLTSKPPGTTEWE Sbjct: 684 YDLTSKPPGTTEWE 697 >3TQI-A nrPDB Length = 527 Score = 666 bits (1719), Expect = 0.0, Method: Composition-based stats. Identities = 202/576 (35%), Positives = 295/576 (51%), Gaps = 73/576 (12%) Query: 17 LKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISG 76 LKD H H ++ILD G+QY ++I RRVRE+ V E+ P + I++ II+SG Sbjct: 5 LKDIHQH---RILILDFGSQYAQLIARRVREIGVYCELMPCDIDEETIRDFNPHGIILSG 61 Query: 77 GPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNT 136 GP +V IF IG PVLGICYGMQ M GG V++ + E G + V N Sbjct: 62 GPETVTLSHTLRAPAFIFEIGCPVLGICYGMQTMAYQLGGKVNRTAKAEFGHAQLRVLNP 121 Query: 137 CSLFRGLQKEEV--------VLLTHGDSVDKVADGFKVVARSGN-IVAGIANESKKLYGA 187 LF G++ + V ++HGD V ++ GF+ A + N +A +A+ ++ +G Sbjct: 122 AFLFDGIEDQVSPQGEPLLDVWMSHGDIVSELPPGFEATACTDNSPLAAMADFKRRFFGL 181 Query: 188 QFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGV 247 QFHPEV T G IL +F+ I C +T ++ + IR+I+E+VG +V+V LSGGV Sbjct: 182 QFHPEVTHTPQGHRILAHFVIHICQCIPNWTTKHIIEDSIRDIQEKVGKEQVIVGLSGGV 241 Query: 248 DSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKK-LGIQVKVINAAHSFYNG 306 DS V L+++A+ +Q++ V +D G +R E V +K LG +V ++A Sbjct: 242 DSAVTATLVHKAIG-DQLVCVLVDTGLLRLNEVDEVLNVFQKHLGAKVICVDA------- 293 Query: 307 TTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQ 366 + R K L + PEEKRKI G+ F+++ E ++N+K +L Q Sbjct: 294 -------------KDRFMKALKGISDPEEKRKIAGEQFIRVFEEQAKKLNVK----WLGQ 336 Query: 367 GTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGREL 426 GT+ PD+IESA +GK +IKTHHN L L E K+IEPL++ KDEVR LG EL Sbjct: 337 GTIYPDVIESAK-TKTGKGHIIKTHHNVGGLP--LNMELKLIEPLRELFKDEVRKLGLEL 393 Query: 427 GLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRV 486 GLP +L+ RHPFPGPGLAIR++ E NILK K +V Sbjct: 394 GLPADLIYRHPFPGPGLAIRILGEVSA-------EYINILKQADAIFIEELKKSDYYHQV 446 Query: 487 KACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPD-----WE 541 A +P+K+VGV+GD R Y Y+ + + D W Sbjct: 447 SQAF------------------AVFMPLKSVGVKGDARHYGYIIALRAVKTVDFMTAQWA 488 Query: 542 SLI--FLARLIPRMCHNVNRVVYIFGPPVKEPPTDV 575 L FL+++ R+ + + V + +PP + Sbjct: 489 DLPHEFLSKVSHRIVNEIKEVSRVVYDMTNKPPATI 524 Score = 152 bits (384), Expect = 4e-37, Method: Composition-based stats. Identities = 36/109 (33%), Positives = 56/109 (51%), Gaps = 4/109 (3%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSD 644 ++ L+QAD L++S Y ++SQ + PL + +R T D Sbjct: 423 INILKQADAIFIEELKKSDYYHQVSQAFAVFMPLK-SVGVKGDARHYGYIIALRAVKTVD 481 Query: 645 FMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE 693 FMT A +E +V ++V EIK++ SR++YD+T+KPP T EWE Sbjct: 482 FMTAQWADLPHEFLSKVSHRIVNEIKEV---SRVVYDMTNKPPATIEWE 527 >1GPM-A nrPDB Length = 525 Score = 661 bits (1706), Expect = 0.0, Method: Composition-based stats. Identities = 190/575 (33%), Positives = 289/575 (50%), Gaps = 72/575 (12%) Query: 18 KDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGG 77 ++ H H ++ILD G+QY +++ RRVREL V E++ + I++ II+SGG Sbjct: 3 ENIHKH---RILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGG 59 Query: 78 PNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTC 137 P S E++P +F G PV G+CYGMQ M GG V + RE G + V N Sbjct: 60 PESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDS 119 Query: 138 SLFRGLQKEEV--------VLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQ 188 +L RG++ V ++HGD V + F VA + + A +ANE K+ YG Q Sbjct: 120 ALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFITVASTESCPFAIMANEEKRFYGVQ 179 Query: 189 FHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVD 248 FHPEV T G +L+ F+ DI C +T + + I+E+VG KV++ LSGGVD Sbjct: 180 FHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVD 239 Query: 249 STVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEAL-KKLGIQVKVINAAHSFYNGT 307 S+V LL+RA+ + + V +DNG +R E++ V + G+ + + A Sbjct: 240 SSVTAMLLHRAIGK-NLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAE------- 291 Query: 308 TTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQG 367 R L PE KRKIIG FV++ +E ++ + +LAQG Sbjct: 292 -------------DRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLE---DVKWLAQG 335 Query: 368 TLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELG 427 T+ PD+IESA+ A+GKA +IK+HHN L ++++ ++EPLK+ KDEVR +G ELG Sbjct: 336 TIYPDVIESAA-SATGKAHVIKSHHNVGGLPKEMKM--GLVEPLKELFKDEVRKIGLELG 392 Query: 428 LPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVK 487 LP +++ RHPFPGPGL +RV+ + E ++L+ + L +V Sbjct: 393 LPYDMLYRHPFPGPGLGVRVLGEVK-------KEYCDLLRRADAIFIEELRKADLYDKVS 445 Query: 488 ACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPD-----WES 542 T LP+++VGV GD R Y +V + + + D W Sbjct: 446 QAFT------------------VFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAH 487 Query: 543 LI--FLARLIPRMCHNVNRVVYIFGPPVKEPPTDV 575 L FL R+ R+ + VN + + +PP + Sbjct: 488 LPYDFLGRVSNRIINEVNGISRVVYDISGKPPATI 522 Score = 155 bits (392), Expect = 6e-38, Method: Composition-based stats. Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 6/109 (5%) Query: 586 STLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDF 645 LR+AD LR++ K+SQ + P+ + V +R T DF Sbjct: 422 DLLRRADAIFIEELRKADLYDKVSQAFTVFLPVR-SVGVMGDGRKYDWVVSLRAVETIDF 480 Query: 646 MTGIPATPGNEIPVEVVLKMVTE-IKKIPGISRIMYDLTSKPPGTTEWE 693 MT A +P + + ++ I ++ GISR++YD++ KPP T EWE Sbjct: 481 MTAHWA----HLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE 525 >5TW7-A nrPDB Length = 529 Score = 660 bits (1702), Expect = 0.0, Method: Composition-based stats. Identities = 201/564 (35%), Positives = 296/564 (52%), Gaps = 61/564 (10%) Query: 25 EGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAE 84 + ++ILD G+Q ++I RRVRE V E+ + P IK + II+SGGPNSVY Sbjct: 11 QDKILILDFGSQVTRLIARRVREAHVYCELHSFDMPLDEIKAFNPKGIILSGGPNSVYES 70 Query: 85 DAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQ 144 D D IF +G PVLGICYGMQ M GG V + RE G + + L RG+Q Sbjct: 71 D-YQADTGIFDLGIPVLGICYGMQFMAHHLGGEVQPGNQREFGYAQVKTID-SGLTRGIQ 128 Query: 145 KEEV----VLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENG 199 + V ++HGD V K+ DGF V+ + + +A + N K+ YG QFHPEV T+ G Sbjct: 129 DDAPNTLDVWMSHGDKVSKLPDGFAVIGDTPSCPIAMMENTEKQFYGIQFHPEVTHTKQG 188 Query: 200 KVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRA 259 + +L F+ DI G +T+ N E + +I+E+VG+ +V++ LSGGVDS+V AL++RA Sbjct: 189 RALLNRFVLDICGAQPGWTMPNYIEEAVAKIREQVGSDEVILGLSGGVDSSVAAALIHRA 248 Query: 260 LNQEQVIAVHIDNGFMRKRESQSVEEAL-KKLGIQVKVINAAHSFYNGTTTLPISDEDRT 318 + +Q+ V +D+G +R E + V + + LG++V ++A F Sbjct: 249 IG-DQLTCVFVDHGLLRLNEGKMVMDMFARNLGVKVIHVDAEGQF--------------- 292 Query: 319 PRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESAS 378 L T PE+KRKIIG F+++ + E +LAQGT+ PD+IESA Sbjct: 293 -----MAKLAGVTDPEKKRKIIGAEFIEVFD---AEEKKLTNAKWLAQGTIYPDVIESAG 344 Query: 379 LVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPF 438 + KA IK+HHN L ++ K++EPL+D KDEVR LG LGLP E+V RHPF Sbjct: 345 -AKTKKAHAIKSHHNVGGLPENMKL--KLLEPLRDLFKDEVRELGVALGLPREMVYRHPF 401 Query: 439 PGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKL 498 PGPGL +R++ + E ++L+ D + TT+E+ Sbjct: 402 PGPGLGVRILGEVK-------KEYADLLRQADDIFIQELRN----------TTDENGTSW 444 Query: 499 MQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPD-----WESLIF--LARLIP 551 +TS A LP+K+VGV GD R+Y YV + + D W L + L R+ Sbjct: 445 YDLTS--QAFAVFLPVKSVGVMGDGRTYDYVVALRAVITSDFMTAHWAELPYSLLGRVSN 502 Query: 552 RMCHNVNRVVYIFGPPVKEPPTDV 575 R+ + V + + +PP + Sbjct: 503 RIINEVKGINRVVYDVSGKPPATI 526 Score = 138 bits (348), Expect = 6e-33, Method: Composition-based stats. Identities = 35/115 (30%), Positives = 54/115 (46%), Gaps = 12/115 (10%) Query: 586 STLRQADFEAHNILRES------GYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRT 639 LRQAD LR + + SQ + P+ + + V +R Sbjct: 420 DLLRQADDIFIQELRNTTDENGTSWYDLTSQAFAVFLPVK-SVGVMGDGRTYDYVVALRA 478 Query: 640 FITSDFMTGIPATPGNEIPVEVVLKMVTE-IKKIPGISRIMYDLTSKPPGTTEWE 693 ITSDFMT A E+P ++ ++ I ++ GI+R++YD++ KPP T EWE Sbjct: 479 VITSDFMTAHWA----ELPYSLLGRVSNRIINEVKGINRVVYDVSGKPPATIEWE 529 >4WIM-A nrPDB Length = 568 Score = 632 bits (1631), Expect = 0.0, Method: Composition-based stats. Identities = 176/607 (28%), Positives = 279/607 (45%), Gaps = 98/607 (16%) Query: 15 GDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIII 74 G + +G + +++L+ G+QY +I +R+ + + SE IK+ + +I+ Sbjct: 11 GSMAEGEEY--DKILVLNFGSQYFHLIVKRLNNIKIFSETKDYGVELKDIKDMNIKGVIL 68 Query: 75 SGGPNSVYAEDAPWFDPAIFTI----GKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFN 130 SGGP SV +P +F P+ GICYGMQ + G V K E G + Sbjct: 69 SGGPYSVTEAGSPHLKKEVFEYFLEKKIPIFGICYGMQEIAVQMNGEVKKSKTSEYGCTD 128 Query: 131 I-------------------------------SVDNTCSLFRGLQKEEV-VLLTHGDSVD 158 + ++ TC LF ++ + V + H D V Sbjct: 129 VNILRNDNINNITYCRNFGDSSSAMDLYSNYKLMNETCCLFENIKSDITTVWMNHNDEVT 188 Query: 159 KVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTF 217 K+ + F +V+ S N + I N+ +YG Q+HPEV + +G+++ NF Y+I C F Sbjct: 189 KIPENFYLVSSSENCLICSIYNKEYNIYGVQYHPEVYESLDGELMFYNFAYNICKCKKQF 248 Query: 218 TVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRK 277 ++ I++ V+ +SGG+DSTV A ++ +E+ + IDNG +RK Sbjct: 249 DPIRYHELELKNIEKYKHDHYVIAAMSGGIDSTVAAAYTHKIF-KERFFGIFIDNGLLRK 307 Query: 278 RESQSVEEALKKL--GIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEE 335 E+++V LK + + I+A+ +F + L T PE+ Sbjct: 308 NEAENVYTFLKSTFPDMNITKIDASENFLSN--------------------LQGVTDPEQ 347 Query: 336 KRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDT 395 KRKIIG F++ + + +++ + FL QGTL PD+IES + ++ IKTHHN Sbjct: 348 KRKIIGKLFIEEFEKAVNNIDIDINKTFLLQGTLYPDIIESK--CSKNLSDTIKTHHNVG 405 Query: 396 ELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYI 455 L + L+ K+ EP K KD+V+ L REL LPEE+ +RHPFPGPGLAIRVI + Sbjct: 406 GLPKNLK--FKLFEPFKYLFKDDVKTLSRELNLPEEITNRHPFPGPGLAIRVIGEINKHK 463 Query: 456 CKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIK 515 NIL+ V D + K + L ++ A LL K Sbjct: 464 L-------NILREVDDIFINDLKQYGLYNQISQAF------------------AVLLSSK 498 Query: 516 TVGVQGDCRSYSYVCGISSK-----DEPDWESLIF--LARLIPRMCHNVNRVVYIFGPPV 568 +VGV+GD RSY YVC + + +W + + L ++ R+ V V I Sbjct: 499 SVGVRGDARSYDYVCVLRAVKTSSFMTANWYQIPYDILDKITTRILSEVKGVNRILYDVS 558 Query: 569 KEPPTDV 575 +PP + Sbjct: 559 SKPPATI 565 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 36/110 (32%), Positives = 56/110 (50%), Gaps = 6/110 (5%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSD 644 L+ LR+ D N L++ G +ISQ +L S V+R TS Sbjct: 464 LNILREVDDIFINDLKQYGLYNQISQAFAVLLS-SKSVGVRGDARSYDYVCVLRAVKTSS 522 Query: 645 FMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 FMT +IP +++ K+ T I ++ G++RI+YD++SKPP T E+E Sbjct: 523 FMTANW----YQIPYDILDKITTRILSEVKGVNRILYDVSSKPPATIEFE 568 >2YWB-A nrPDB Length = 503 Score = 615 bits (1586), Expect = e-176, Method: Composition-based stats. Identities = 210/559 (37%), Positives = 293/559 (52%), Gaps = 71/559 (12%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 V++LD G+QY ++I RR+REL S I P + P + + +A+I+SGGP SV+ DAP Sbjct: 2 VLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLKHRPQALILSGGPRSVFDPDAP 61 Query: 88 WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEE 147 DP +F+ G P+LGICYGMQ++ + GG V + E G + + LFRGL+ E Sbjct: 62 RPDPRLFSSGLPLLGICYGMQLLAQELGGRVERAGRAEYGKA-LLTRHEGPLFRGLEGEV 120 Query: 148 VVLLTHGDSVDKVADGFKVVARS-GNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNF 206 V ++H D+V G++VVA + N VA IA+ + YG QFHPEV T G IL+NF Sbjct: 121 QVWMSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFHPEVAHTPKGMQILENF 180 Query: 207 LYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVI 266 L ++AG +T ++ E +RE++ER G +VL+ +SGGVDS+ LL +A + Sbjct: 181 L-ELAGVKRDWTPEHVLEELLREVRERAGKDRVLLAVSGGVDSSTLALLLAKAGVDH--L 237 Query: 267 AVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKT 326 AV +D+G +R E + VE AL+ LG+ + V++A ++R K Sbjct: 238 AVFVDHGLLRLGEREEVEGALRALGVNLLVVDA--------------------KERFLKA 277 Query: 327 LNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAE 386 L PEEKRKIIG FV ++V E + FLAQGTL PD+IESA + K Sbjct: 278 LKGVEDPEEKRKIIGREFVAAFSQVARE---RGPFRFLAQGTLYPDVIESAGGHGAAK-- 332 Query: 387 LIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIR 446 IK+HHN L L E +++EP + KDEVR L LGLP+ L RHPFPGPGLA+R Sbjct: 333 -IKSHHNVGGLPEDL--EFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAVR 389 Query: 447 VICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHS 506 V+ E IL+ D S+ + L ++V Sbjct: 390 VLGEVT-------EERLEILRRADDIFTSLLREWGLYEKVAQAL---------------- 426 Query: 507 LNAFLLPIKTVGVQGDCRSYSYVCGISSK-----DEPDWESLI--FL---ARLIPRMCHN 556 A L P+++VGV GD R Y YV + + DW L FL AR I R Sbjct: 427 --AVLTPVRSVGVAGDERKYGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITRRVPE 484 Query: 557 VNRVVYIFGPPVKEPPTDV 575 + RVVY +PP + Sbjct: 485 IGRVVY---DLTSKPPATI 500 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 39/110 (35%), Positives = 58/110 (52%), Gaps = 6/110 (5%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSD 644 L LR+AD ++LRE G K++Q +LTP+ + + +R T D Sbjct: 399 LEILRRADDIFTSLLREWGLYEKVAQALAVLTPVR-SVGVAGDERKYGYVLALRAVTTED 457 Query: 645 FMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 FMT A +P+E + + I +++P I R++YDLTSKPP T EWE Sbjct: 458 FMTADWA----RLPLEFLDEAARRITRRVPEIGRVVYDLTSKPPATIEWE 503 >2DPL-A nrPDB Length = 308 Score = 335 bits (858), Expect = 4e-92, Method: Composition-based stats. Identities = 123/366 (33%), Positives = 176/366 (48%), Gaps = 80/366 (21%) Query: 223 ELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQS 282 E +REI+E VG SK ++ LSGGVDS+ L ++A+ +++ AV ++ GF+RK E + Sbjct: 7 VEEKVREIRETVGDSKAIIALSGGVDSSTAAVLAHKAIG-DRLHAVFVNTGFLRKGEPEF 65 Query: 283 VEEALK-KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIG 341 V + + + G+ + ++A F++ L T PEEKRKIIG Sbjct: 66 VVKTFRDEFGMNLHYVDAQDRFFS--------------------ALKGVTDPEEKRKIIG 105 Query: 342 DTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKL 401 F+++ EV ++ + +L QGT+ PD IES IK+HHN L KL Sbjct: 106 RVFIEVFEEVAKKIGAE----YLIQGTIAPDWIESQGK--------IKSHHNVGGLPEKL 153 Query: 402 REEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPE 461 K+IEPL+D +KDEVR L + LGLPE++ +R PFPGPGLA+RVI P + E Sbjct: 154 NL--KLIEPLRDLYKDEVRELAKFLGLPEKIYNRMPFPGPGLAVRVIGEVTPEKIRIVRE 211 Query: 462 TNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAF--LLPIKTVGV 519 N I+ EE+ E+ L AF LL +KTVGV Sbjct: 212 ANAIV-------------------------EEEVER----AGLRPWQAFAVLLGVKTVGV 242 Query: 520 QGDCRSYSYVCGISSKDEPD----------WESLIFLARLIPRMCHNVNRVVYIFGPPVK 569 QGD R+Y + + D WE L +A I V RV+Y Sbjct: 243 QGDIRAYKETIAVRIVESIDGMTANAMNVPWEVLQRIAFRITSEIPEVGRVLY---DITN 299 Query: 570 EPPTDV 575 +PP + Sbjct: 300 KPPATI 305 Score = 83.3 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 51/110 (46%), Gaps = 8/110 (7%) Query: 585 LSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSD 644 + +R+A+ + +G + Q +L + + + ++ +R + D Sbjct: 206 IRIVREANAIVEEEVERAGL--RPWQAFAVLLGVK-TVGVQGDIRAYKETIAVRIVESID 262 Query: 645 FMTGIPATPGNEIPVEVVLKMVTEI-KKIPGISRIMYDLTSKPPGTTEWE 693 MT +P EV+ ++ I +IP + R++YD+T+KPP T E+E Sbjct: 263 GMTA----NAMNVPWEVLQRIAFRITSEIPEVGRVLYDITNKPPATIEFE 308 >2VPI-A nrPDB Length = 218 Score = 274 bits (701), Expect = 8e-74, Method: Composition-based stats. Identities = 195/198 (98%), Positives = 195/198 (98%) Query: 22 HHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSV 81 EGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSV Sbjct: 21 QSMEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSV 80 Query: 82 YAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFR 141 YAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFR Sbjct: 81 YAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFR 140 Query: 142 GLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKV 201 GLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKV Sbjct: 141 GLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKV 200 Query: 202 ILKNFLYDIAGCSGTFTV 219 ILKNFLYDIAGCSGTFTV Sbjct: 201 ILKNFLYDIAGCSGTFTV 218 >4WIN-A nrPDB Length = 249 Score = 254 bits (649), Expect = 9e-68, Method: Composition-based stats. Identities = 63/242 (26%), Positives = 106/242 (43%), Gaps = 39/242 (16%) Query: 15 GDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIII 74 G + +G + +++L+ G+QY +I +R+ + + SE IK+ + +I+ Sbjct: 10 GSMAEGEEY--DKILVLNFGSQYFHLIVKRLNNIKIFSETKDYGVELKDIKDMNIKGVIL 67 Query: 75 SGGPNSVYAEDAPWFDPAIFTI----GKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFN 130 SGGP SV +P +F P+ GICYGMQ + G V K E G + Sbjct: 68 SGGPYSVTEAGSPHLKKEVFEYFLEKKIPIFGICYGMQEIAVQMNGEVKKSKTSEYGCTD 127 Query: 131 I-------------------------------SVDNTCSLFRGLQKEEV-VLLTHGDSVD 158 + ++ TC LF ++ + V + H D V Sbjct: 128 VNILRNDNINNITYCRNFGDSSSAMDLYSNYKLMNETCCLFENIKSDITTVWMNHNDEVT 187 Query: 159 KVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTF 217 K+ + F +V+ S N + I N+ +YG Q+HPEV + +G+++ NF Y+I C F Sbjct: 188 KIPENFYLVSSSENCLICSIYNKEYNIYGVQYHPEVYESLDGELMFYNFAYNICKCKKQF 247 Query: 218 TV 219 Sbjct: 248 DP 249 >1WL8-A nrPDB Length = 189 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 67/186 (36%), Positives = 97/186 (52%), Gaps = 2/186 (1%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 +VI+D G QY I R +R L V+++I P TP IK + II SGGP+ + Sbjct: 3 IVIMDNGGQYVHRIWRTLRYLGVETKIIPNTTPLEEIKAMNPKGIIFSGGPSLENTGNCE 62 Query: 88 WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEE 147 P+LGIC G Q++ K FGG V + E + I + + +F+GL K Sbjct: 63 KVLEHYDEFNVPILGICLGHQLIAKFFGGKVGRGEKAEYSLVEIEIIDENEIFKGLPKRL 122 Query: 148 VVLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVILKNF 206 V +H D V ++ FK++ARS + + +E +YG QFHPEV TE G+ IL+NF Sbjct: 123 KVWESHMDEVKELPPKFKILARSETCPIEAMKHEELPIYGVQFHPEVAHTEKGEEILRNF 182 Query: 207 LYDIAG 212 + G Sbjct: 183 A-KLCG 187 >2A9V-A nrPDB Length = 212 Score = 233 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 61/202 (30%), Positives = 96/202 (47%), Gaps = 8/202 (3%) Query: 27 AVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGG-PNSVYAED 85 + ++D G Q+ R +REL V ++I P + + + G +++SGG PN D Sbjct: 15 KIYVVDNGGQWTHREWRVLRELGVDTKIVPNDIDSSEL--DGLDGLVLSGGAPNIDEELD 72 Query: 86 A-PWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQ 144 I P+LGIC G Q + FG +V K E G +SV ++ ++F GL Sbjct: 73 KLGSVGKYIDDHNYPILGICVGAQFIALHFGASVVKAKHPEFGKTKVSVMHSENIFGGLP 132 Query: 145 KEEVVLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVIL 203 E V H D + + D F + A S V G ++++ +Y QFHPEV T+ G+ I Sbjct: 133 SEITVWENHNDEIINLPDDFTLAASSATCQVQGFYHKTRPIYATQFHPEVEHTQYGRDIF 192 Query: 204 KNFLYDIAGCSGTFTVQNRELE 225 +NF I C+ +Q + Sbjct: 193 RNF---IGICASYREIQKENFQ 211 >2LXN-A nrPDB Length = 188 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 67/189 (35%), Positives = 100/189 (52%), Gaps = 6/189 (3%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIK-EQGFRAIIISGGPNSVYAEDA 86 +VILD G QY I R ++ + V S+I P TP I+ + + II+SGGP+ A++ Sbjct: 2 IVILDNGGQYVHRIHRSLKYIGVSSKIVPNTTPLEEIESNKEVKGIILSGGPDIEKAKNC 61 Query: 87 PWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKE 146 P+LGIC G Q++ +GG V + E + + VD LF+ + +E Sbjct: 62 ---IDIALNAKLPILGICLGHQLIALAYGGEVGRAEAEEYALTKVYVDKENDLFKNVPRE 118 Query: 147 EVVLLTHGDSVDKVADGFKVVARSGNI-VAGIANESKKLYGAQFHPEVGLTENGKVILKN 205 +H D V KV +GF+++A S V + +++K +YG QFHPEV TE G ILKN Sbjct: 119 FNAWASHKDEVKKVPEGFEILAHSDICQVEAMKHKTKPIYGVQFHPEVAHTEYGNEILKN 178 Query: 206 FLYDIAGCS 214 F + G Sbjct: 179 FC-KVCGYK 186 >1QDL-B nrPDB Length = 195 Score = 159 bits (401), Expect = 5e-39, Method: Composition-based stats. Identities = 57/194 (29%), Positives = 81/194 (41%), Gaps = 9/194 (4%) Query: 26 GAVVILDAGAQYGKVIDRRVRELFVQSEIFPLE-TPAFAIKEQGFRAIIISGGPNSVYA- 83 +I+D + I + V EL + + I+ +IIS GP + Sbjct: 2 DLTLIIDNYDSFVYNIAQIVGELGSYPIVIRNDEISIKGIERIDPDRLIISPGPGTPEKR 61 Query: 84 EDAPWFDPAIFTIGK--PVLGICYGMQMMNKVFGGTVHKK-SVREDGVFNISVDNTCSL- 139 ED I +GK P+LG+C G Q + FG + + V + NI + N L Sbjct: 62 EDIGVSLDVIKYLGKRTPILGVCLGHQAIGYAFGAKIRRARKVFHGKISNIILVNNSPLS 121 Query: 140 -FRGLQKEEVVLLTHGDSVDKVADGFKVVARS--GNIVAGIANESKKLYGAQFHPEVGLT 196 + G+ KE H VD+V V A S N + I +E +YG QFHPE T Sbjct: 122 LYYGIAKEFKATRYHSLVVDEVHRPLIVDAISAEDNEIMAIHHEEYPIYGVQFHPESVGT 181 Query: 197 ENGKVILKNFLYDI 210 G IL NFL + Sbjct: 182 SLGYKILYNFLNRV 195 >1I7S-B nrPDB Length = 193 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 37/184 (20%), Positives = 72/184 (39%), Gaps = 4/184 (2%) Query: 28 VVILDAGAQYGKVIDRRVRELF----VQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYA 83 +++LD + + ++R + E ++ +++S GP + Sbjct: 4 ILLLDNVDSFTYNLVDQLRASGHQVVIYRNQIGAEVIIERLQHMEQPVLMLSPGPGTPSE 63 Query: 84 EDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGL 143 P++GIC G Q + + +GG V + G + + +F G+ Sbjct: 64 AGCMPELLQRLRGQLPIIGICLGHQAIVEAYGGQVGQAGEILHGKASAIAHDGEGMFAGM 123 Query: 144 QKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVIL 203 V H + V AR G +V + ++ +++ G QFHPE LT +G +L Sbjct: 124 ANPLPVARYHSLVGSNIPADLTVNARFGEMVMAVRDDRRRVCGFQFHPESILTTHGARLL 183 Query: 204 KNFL 207 + L Sbjct: 184 EQTL 187 >1O1Y-A nrPDB Length = 239 Score = 128 bits (321), Expect = 8e-30, Method: Composition-based stats. Identities = 38/135 (28%), Positives = 54/135 (40%), Gaps = 10/135 (7%) Query: 68 GFRAIIISGGPNSVYAEDAPWFDPAIFTIG-------KPVLGICYGMQMMNKVFGGTVHK 120 + +++ GG Y E+ F F + P LGIC G QM+ KV G +V++ Sbjct: 57 EYSLVVLLGGYMGAYEEEKYPFLKYEFQLIEEILKKEIPFLGICLGSQMLAKVLGASVYR 116 Query: 121 -KSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIAN 179 K+ E G + + + FR V HGD+ D +V G Sbjct: 117 GKNGEEIGWYFVEKVSDNKFFREFPDRLRVFQWHGDTFDLPRRATRVFTSEKYENQGFV- 175 Query: 180 ESKKLYGAQFHPEVG 194 K G QFH EVG Sbjct: 176 -YGKAVGLQFHIEVG 189 >3FIJ-A nrPDB Length = 254 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 46/191 (24%), Positives = 83/191 (43%), Gaps = 36/191 (18%) Query: 39 KVIDRRVRELFVQSEIFPLETPAFAIKEQGF-RAIIISGGPN---SVYAED-----APWF 89 + ++++ P++ P+ A++ ++++GG + +Y E+ +F Sbjct: 31 QRYVDAIQKVGGFPIALPIDDPSTAVQAISLVDGLLLTGGQDITPQLYLEEPSQEIGAYF 90 Query: 90 DP----------AIFTIGKPVLGICYGMQMMNKVFGGTVHK-------------KSVRED 126 P A GKP+ IC GMQ++N GGT+++ + V E Sbjct: 91 PPRDSYEIALVRAALDAGKPIFAICRGMQLVNVALGGTLYQDISQVETKALQHLQRVDEQ 150 Query: 127 -GVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARS--GNIVAGIANESKK 183 G I ++ T L + +++V H + K+A FKV AR+ G I A + Sbjct: 151 LGSHTIDIEPTSELAKHHPNKKLVNSLHHQFIKKLAPSFKVTARTADGMIEAVEGDNLPS 210 Query: 184 LY-GAQFHPEV 193 Y G Q+HPE+ Sbjct: 211 WYLGVQWHPEL 221 >1C30-B nrPDB Length = 382 Score = 85.6 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 42/195 (21%), Positives = 68/195 (34%), Gaps = 14/195 (7%) Query: 28 VVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAP 87 VV D GA+ + I R + + + I P +T A + + I +S GP D Sbjct: 194 VVAYDFGAK--RNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYA 251 Query: 88 -WFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKE 146 PV GI G Q++ G K G + D ++ Sbjct: 252 ITAIQKFLETDIPVFGISLGHQLLALASGAKTVKMKFGHHGGNHPVKDVEKNVV------ 305 Query: 147 EVVLLTHGDSVDK--VADGFKVVARS--GNIVAGIANESKKLYGAQFHPEVGLTENGKV- 201 + HG +VD+ + +V +S + GI K + Q HPE + Sbjct: 306 MITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAP 365 Query: 202 ILKNFLYDIAGCSGT 216 + +F+ I T Sbjct: 366 LFDHFIELIEQYRKT 380 >2E18-A nrPDB Length = 257 Score = 76.8 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 52/225 (23%), Positives = 87/225 (38%), Gaps = 54/225 (24%) Query: 219 VQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKR 278 V R LE IRE G + V++ +SGGVDS L +AL +E+V+ + M Sbjct: 9 VIERILEFIRE----KGNNGVVIGISGGVDSATVAYLATKALGKEKVLGL-----IMPYF 59 Query: 279 ESQSVEEA---LKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEE 335 E++ VE+A +KLGI KVIN + + L + + Sbjct: 60 ENKDVEDAKLVAEKLGIGYKVINI-----------------KPIVDSFVENLELNLDRKG 102 Query: 336 KRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDT 395 I+ T + + + + GT S ++E + T Sbjct: 103 LGNIMSRTRMIMLYAHANSLGR------IVLGT-------------SNRSEFL------T 137 Query: 396 ELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPG 440 K + P+ + +K EV + + +G+PE +V + P G Sbjct: 138 GYFTKWGDGASDYAPIINLYKTEVWEIAKRIGVPERIVKKKPSAG 182 >3R75-A nrPDB Length = 645 Score = 68.3 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 43/202 (21%), Positives = 79/202 (39%), Gaps = 23/202 (11%) Query: 15 GDLKD-GHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAII 73 G++ D +I+DA + +I +++ L + +E+ A+ + ++ Sbjct: 435 GEMADELAELSGCRALIVDAEDHFTAMIAQQLSSLGLATEV--CGV-HDAVDLARYDVVV 491 Query: 74 ISGGPNSVYAEDAPWF------DPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDG 127 + GP P + GKP + +C Q++N + G + ++ V G Sbjct: 492 MGPGPGDPSDAGDPRIARLYAWLRHLIDEGKPFMAVCLSHQILNAILGIPLVRREVPNQG 551 Query: 128 VFNISVDNTCSLFRGLQK----EEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESK- 182 + + +D LF ++ V T D +D DG VA S + G + + Sbjct: 552 I-QVEID----LFGQRERVGFYNTYVAQTVRDEMDV--DGVGTVAISRDPRTGEVHALRG 604 Query: 183 -KLYGAQFHPEVGLTENGKVIL 203 QFH E LT +G IL Sbjct: 605 PTFSSMQFHAESVLTVDGPRIL 626 >3L7N-A nrPDB Length = 236 Score = 65.2 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 36/171 (21%), Positives = 64/171 (37%), Gaps = 17/171 (9%) Query: 38 GKVIDRRVRELFVQ-SEIFPLETPAFAIKEQGFRAIIISGGPNSV--YAEDAPWFD---- 90 + +R V ++++ E I + +I+ GGP S ++ P++D Sbjct: 16 AYLAWAALRGHDVSMTKVYRYEKLPKDIDDF--DMLILMGGPQSPSSTKKEFPYYDAQAE 73 Query: 91 ----PAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSL---FRGL 143 K ++G+C G Q+M +G +E G + IS+ + Sbjct: 74 VKLIQKAAKSEKIIVGVCLGAQLMGVAYGADYLHSPKKEIGNYLISLTEAGKMDSYLSDF 133 Query: 144 QKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVG 194 + +V HGD + + D +V+A S I K Y Q H E Sbjct: 134 SDDLLVGHWHGD-MPGLPDKAQVLAISQGCPRQIIKFGPKQYAFQCHLEFT 183 >3M3P-A nrPDB Length = 250 Score = 62.5 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 29/147 (19%), Positives = 44/147 (29%), Gaps = 13/147 (8%) Query: 55 FPLETPA-FAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIG------KPVLGICYGM 107 P I++ + + GGP S D PW + I PV+G C G Sbjct: 36 MDRSDPLPAEIRD--CSGLAMMGGPMSAND-DLPWMPTLLALIRDAVAQRVPVIGHCLGG 92 Query: 108 QMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFR--GLQKEEVVLLTHGDSVDKVADGFK 165 Q++ K GG V E G + G E + H + Sbjct: 93 QLLAKAMGGEVTDSPHAEIGWVRAWPQHVPQALEWLGTWDELELFEWHYQTFSIPPGAVH 152 Query: 166 VVARSGNIVAGIANESKKLYGAQFHPE 192 ++ + + G Q H E Sbjct: 153 ILRSEHCANQAYVLDDLHI-GFQCHIE 178 >4GUD-A nrPDB Length = 211 Score = 60.6 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 30/139 (21%), Positives = 50/139 (35%), Gaps = 25/139 (17%) Query: 91 PAIFTIGKPVLGICYGMQM--------------MNKVFG---GTVHKKS-----VREDGV 128 + + KP+LGIC GMQ+ + + G G V + G Sbjct: 66 ELVKRVEKPLLGICLGMQLLGKLSEEKGQKADEIVQCLGLVDGEVRLLQTGDLPLPHMGW 125 Query: 129 FNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQ 188 + V LF G++ + H + + A ++ YG Q Sbjct: 126 NTVQVKEGHPLFNGIEPDAYFYFVHS--FAMPVGDYTIAQCEYGQPFSAAIQAGNYYGVQ 183 Query: 189 FHPEVGLTENGKVILKNFL 207 FHPE ++ G +++NFL Sbjct: 184 FHPERS-SKAGARLIQNFL 201 >1OX5-A nrPDB Length = 555 Score = 54.4 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 40/198 (20%), Positives = 71/198 (35%), Gaps = 44/198 (22%) Query: 65 KEQGFRA---IIISG-GPNS-----VYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFG 115 K+ +I+ G G ++ GKP++GIC G+Q + F Sbjct: 38 KDFNISGTSRLILPGVGNYGHFVDNLFNRGFEKPIREYIESGKPIMGICVGLQAL---FA 94 Query: 116 GTVHKKS--------------------VREDGVFNISVDNTCSLFRGLQKEEVVLLTH-- 153 G+V V E G + + +LF GL + H Sbjct: 95 GSVESPKSTGLNYIDFKLSRFDDSEKPVPEIGWNS--CIPSENLFFGLDPYKRYYFVHSF 152 Query: 154 -----GDSVDKVA-DGFKVV-ARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNF 206 + + DG+K+ A+ G+ A ++ QFHPE + G +++NF Sbjct: 153 AAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFATQFHPEKSG-KAGLNVIENF 211 Query: 207 LYDIAGCSGTFTVQNREL 224 L + ++ + +EL Sbjct: 212 LKQQSPPIPNYSAEEKEL 229 >1XNG-A nrPDB Length = 268 Score = 52.1 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 45/216 (20%), Positives = 74/216 (34%), Gaps = 44/216 (20%) Query: 222 RELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQ 281 + + + ++ G KV+ LSGG+DS V L + +E A+ + + Sbjct: 11 YLCDFLEKEVQKRGFKKVVYGLSGGLDSAVVGVLCQKVF-KENAHALLMPSSVSMPENKT 69 Query: 282 SVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIG 341 +K I + A Y+ + D T + L M + Sbjct: 70 DALNLCEKFSIPYTEYSIAP--YDAIFSSHFKDASLTRKGNFCARLRMA--------FLY 119 Query: 342 DTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKL 401 D +K + VIG N E L GTL DL A Sbjct: 120 DYSLKSDSLVIGTSNK--SERMLGYGTLFGDL-----ACA-------------------- 152 Query: 402 REEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 I P+ + K EV L R L +P++++++ P Sbjct: 153 ------INPIGELFKTEVYELARRLNIPKKILNKPP 182 >4XFD-A nrPDB Length = 283 Score = 50.2 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 43/217 (19%), Positives = 80/217 (36%), Gaps = 38/217 (17%) Query: 226 CIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEE 285 I++ + G +++ +SGGVDS L RA VE+ Sbjct: 42 FIQQCLKDSGLKTLVLGISGGVDSLTAGLLAQRA-----------------------VEQ 78 Query: 286 ALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFV 345 ++ G + A+ F + ++ + +L + EE+ IG + Sbjct: 79 LREQTG------DQAYRFIAVRLPYQVQQDEADAQ----ASLATIRADEEQTVNIGPSVK 128 Query: 346 KIANEVIGEMNLKPEEVFLAQGTLRPDL--IESASLVASGKAELIKTHH---NDTELIRK 400 +A ++ L+P + G ++ + + ++ + +I T H K Sbjct: 129 ALAEQLEALEGLEPAKSDFVIGNIKARIRMVAQYAIAGARGGLVIGTDHAAEAVMGFFTK 188 Query: 401 LREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 + + PL K +VR L R LG PE LV + P Sbjct: 189 FGDGACDLAPLSGLAKHQVRALARALGAPENLVEKIP 225 >2YWJ-A nrPDB Length = 186 Score = 49.0 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 36/154 (23%), Positives = 63/154 (40%), Gaps = 20/154 (12%) Query: 68 GFRAIIISGGPNSV--YAEDAPWFDPAIFTIGKPVLGICYGM----------QMMNKVFG 115 G A+II GG ++ I P+LG C GM Q++ ++ Sbjct: 37 GIDALIIPGGESTAIGKLMKKYGLLEKIKNSNLPILGTCAGMVLLSKGTGINQILLELMD 96 Query: 116 GTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVA 175 TV + + G + F+ L K V + ++D +V+AR G+ + Sbjct: 97 ITVKRNA---YGR-QVDSFEKEIEFKDLGKVYGVFIRAPVVDKILSDDVEVIARDGDKIV 152 Query: 176 GIANESKKLYGAQFHPEVGLTENGKVILKNFLYD 209 G+ + K FHPE+ +E+G + K F+ + Sbjct: 153 GV--KQGKYMALSFHPEL--SEDGYKVYKYFVEN 182 >5WP0-A nrPDB Length = 279 Score = 48.6 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 51/227 (22%), Positives = 82/227 (36%), Gaps = 32/227 (14%) Query: 221 NRELECIREIKERV----------GTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHI 270 ++ + EIK+RV +++ +SGGVDST C L A+N+ + Sbjct: 15 KVSIDPVEEIKKRVDFIKGKLLEAHCKSLILGISGGVDSTTCGRLAQLAVNELNLETQSS 74 Query: 271 DNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMT 330 D F+ R +++ + + ++ I HS L Sbjct: 75 DYQFIAVRLPYGIQQDEDEAQLALQFIQPTHSISINIKNGVDGLHSANHIALKDTGLL-- 132 Query: 331 TSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKT 390 P + KI FVK N+K +AQ E A V + Sbjct: 133 --PTDSAKI---DFVKG--------NVKARARMIAQ-------YEVAGYVGGLVLGTDHS 172 Query: 391 HHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 N T K + + PL +K +VR + +LG PE+LV + P Sbjct: 173 AENITGFYTKFGDGACDLAPLFGLNKRQVREVAAQLGAPEQLVKKVP 219 >5KHA-A nrPDB Length = 549 Score = 48.6 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 33/174 (18%), Positives = 66/174 (37%), Gaps = 15/174 (8%) Query: 207 LYDIAGCSGTFTVQNRELECI----REIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQ 262 LY + + + + R+ ER G V++ LSGG+DS + A+ A+ Sbjct: 255 LYKVVESAPALETFAEIYQGLVMATRDYVERSGFPGVILGLSGGIDSALTLAIAVDAIGA 314 Query: 263 EQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKR 322 E+V AV + + + + E +++G+ + HS N +P Sbjct: 315 ERVQAVMMPYTYTSQISVEDAAEQARRMGVTFGIAEI-HSIVNSFMQTLYPFFGNSPADA 373 Query: 323 ISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQG--TLRPDLI 374 + L + G + ++N+ + + L+ G TL D++ Sbjct: 374 TEENLQA--------RARGTLLMGLSNKFGNLVLSTGNKSELSVGYCTLYGDMV 419 >3Q4G-A nrPDB Length = 279 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 47/242 (19%), Positives = 84/242 (34%), Gaps = 33/242 (13%) Query: 203 LKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSK---VLVLLSGGVDSTVCTALLNRA 259 +++ + + + Q + IK ++ ++ +++ +SGGVDST C L A Sbjct: 4 MEHKIREEMRVLPSIDPQFEIERRVAFIKRKLTEARYKSLVLGISGGVDSTTCGRLAQLA 63 Query: 260 L----NQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDE 315 + Q + E + +EA + + I HS Sbjct: 64 VEELNQQHNTTEYQFIAVRLPYGEQKDEDEA----QLALSFIRPTHSVSVNIKAGVDGLH 119 Query: 316 DRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIE 375 + + L + + P + I G N+K +AQ E Sbjct: 120 AASHHALANTGL-IPSDPAKVDFIKG--------------NVKARARMVAQ-------YE 157 Query: 376 SASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSR 435 A V + N T K + + PL +K +VR+L + LG PE+LV + Sbjct: 158 IAGYVGGLVLGTDHSAENITGFYTKFGDGACDLAPLFGLNKRQVRLLAKTLGAPEQLVYK 217 Query: 436 HP 437 P Sbjct: 218 TP 219 >3P52-A nrPDB Length = 249 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 41/215 (19%), Positives = 69/215 (32%), Gaps = 48/215 (22%) Query: 225 ECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVE 284 + I+E + + V++ LSGG+DS + L RAL +E V A+ + K + Sbjct: 15 DFIQEKVKNSQSQGVVLGLSGGIDSALVATLCKRAL-KENVFALLMPTQISNKANLEDAL 73 Query: 285 EALKKLGIQVKVINAAH--SFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGD 342 L ++ K+I + + RI +L S + +IG Sbjct: 74 RLCADLNLEYKIIEIQSILDAFIKQSENTTLVSLGNFAARIRMSLLYDYSALKNSLVIG- 132 Query: 343 TFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLR 402 E+ L GT+ DL A Sbjct: 133 -------------TSNKSELLLGYGTIYGDL-----ACA--------------------- 153 Query: 403 EEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 P+ +K E+ L + L L E + + P Sbjct: 154 -----FNPIGSLYKSEIYALAKYLNLHENFIKKAP 183 >3N05-A nrPDB Length = 590 Score = 47.1 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 58/157 (36%), Gaps = 20/157 (12%) Query: 230 IKERVGTSK---VLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEA 286 ++ V + VL+ LSGG+DS + A+ AL + V V + + + E Sbjct: 317 LRAYVAKNGFRSVLIGLSGGIDSALVAAIACDALGAQNVYGVSMPSKYSSDHSKGDAAEL 376 Query: 287 LKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVK 346 ++ G+ + ++ F +L L + ++ G T + Sbjct: 377 ARRTGLNFRTVSIEPMFDAYMASL---------------GLTGLAEENLQSRLRGTTLMA 421 Query: 347 IANEVIGEMNLKPEEVFLAQG--TLRPDLIESASLVA 381 I+N+ + + LA G TL D + + + Sbjct: 422 ISNQEGHIVLAPGNKSELAVGYSTLYGDSVGAYGPIK 458 >1NSY-A nrPDB Length = 271 Score = 46.3 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 82/235 (34%), Gaps = 49/235 (20%) Query: 213 CSGTFTVQNRELECIREIKERV---GTSKVLVLLSGGVDSTVCTALLNRAL-------NQ 262 + + + + +K+ V G ++ +SGG DST+ L A+ Sbjct: 12 VKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVESIREEGGD 71 Query: 263 EQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKR 322 Q IAV + +G Q ++A +L ++ + + F +T SD+ + Sbjct: 72 AQFIAVRLPHG-----TQQDEDDA--QLALKFIKPDKSWKFDIKSTVSAFSDQYQQETGD 124 Query: 323 ISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVAS 382 N VK +I + + +E L GT + A+ + Sbjct: 125 QLTDFNKGN-------------VKARTRMIAQYAIGGQEGLLVLGT------DHAAEAVT 165 Query: 383 GKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 G T + D + PL K + R L +ELG PE L + P Sbjct: 166 G----FFTKYGDGGAD---------LLPLTGLTKRQGRTLLKELGAPERLYLKEP 207 >4F4H-A nrPDB Length = 565 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 29/149 (19%), Positives = 61/149 (40%), Gaps = 14/149 (9%) Query: 230 IKERVGTSK---VLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEA 286 +++ +G + ++ LSGGVDS + A+ AL E+V AV + + + + + Sbjct: 291 VRDYIGKNGFPGAIIGLSGGVDSALVLAVAVDALGAERVRAVMMPSRYTAGISTTDAADM 350 Query: 287 LKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVK 346 +++G++ I A F +L + T + +I G + Sbjct: 351 ARRVGVRYDEIAIAPMFDAFRASLAAE---------FAGLAEDATEENIQARIRGTLLMA 401 Query: 347 IANEVIGEMNLKPEEVFLAQG--TLRPDL 373 ++N+ + + +A G TL D+ Sbjct: 402 LSNKFGSIVLTTGNKSEMAVGYCTLYGDM 430 >3NVA-A nrPDB Length = 535 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 44/231 (19%), Positives = 71/231 (30%), Gaps = 52/231 (22%) Query: 1 MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETP 60 +AL +KL+++ +K+ +H + K+I +L ++ Sbjct: 296 IALVGKYTKLKDSYISIKEAIYHASAYI------GVRPKLIWIESTDLESDTK------N 343 Query: 61 AFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTV-- 118 I II+ G S AE P LGIC+G Q+ F V Sbjct: 344 LNEILG-NVNGIIVLPGFGSRGAEGKIKAIKYAREHNIPFLGICFGFQLSIVEFARDVLG 402 Query: 119 ----------------------HKKSVREDG-----VFNISVDNTCSLFRGLQKEEVVLL 151 +K+V + G + ++ L ++VV Sbjct: 403 LSEANSTEINPNTKDPVITLLDEQKNVTQLGGTMRLGAQKIILKEGTIAYQLYGKKVVYE 462 Query: 152 THGDSVDKVA--------DGFKVVARSGN-IVAGIANESKKLY-GAQFHPE 192 H + G V S N +V I S K + Q HPE Sbjct: 463 RHRHRYEVNPKYVDILEDAGLVVSGISENGLVEIIELPSNKFFVATQAHPE 513 >1L9X-A nrPDB Length = 315 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 27/201 (13%), Positives = 56/201 (27%), Gaps = 39/201 (19%) Query: 30 ILDAGAQYGKVIDRRVREL-FVQSEIFPLETPAFA----IKEQGFRAIIISGGPNSVYAE 84 ++ +Y + V+ L + + P+ I + I+ GG + Sbjct: 44 VMKNYGRY-YIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRS 102 Query: 85 DAPWFDPAIFTIGK---------PVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDN 135 D + + PV G C G + ++ + G + V Sbjct: 103 DYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFT 162 Query: 136 TCSL----FRGLQKEEVV-------------LL------THGDSVDKVADGFKVVARSGN 172 L F+ E ++ T + + K + Sbjct: 163 GGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKI 222 Query: 173 I-VAGIANESKKLYGAQFHPE 192 ++ + +YG Q+HPE Sbjct: 223 EFISTMEGYKYPVYGVQWHPE 243 >5MKQ-A nrPDB Length = 313 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 53/309 (17%), Positives = 97/309 (31%), Gaps = 43/309 (13%) Query: 213 CSGTFTVQNRELECIREIKERV---GTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVH 269 C F + E + R I+ ++LV +SGG DS V +L + + +H Sbjct: 25 CEEHFK-EYFERKVSRTIERYKLLTKDERILVAVSGGKDSAVTAYVLKKLG--YNIECLH 81 Query: 270 IDNGFMRKRESQSVE--EALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTL 327 I+ G E + K +G + ++ G + +R + Sbjct: 82 INLGISGYSEKSEEYAKKQCKLIGAPLHIVRIKEILGYGIGEVKT--------RRPPCSY 133 Query: 328 NMTTSPEEKRKIIGD-TFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAE 386 T KR I+ + + + NL E FL L + K Sbjct: 134 CGLT----KRYIMNKFAYDNGFDAIATGHNLDDEASFLLNNILH------WNTEYLAKGG 183 Query: 387 LIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIR 446 I L ++ + K ++PL + + EV +GL E +V P+ + Sbjct: 184 PI--------LPQQGKFIKK-VKPLYEVTEREVVAYALAVGL-EYIVEECPYARGATTLD 233 Query: 447 VICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHS 506 + K N ++ +KK +K +E + M + Sbjct: 234 MKGVLNELEEKRPGTKFNFVR------GYLKKKKLFEPEIKEKEIKECKICRMPSSGDIC 287 Query: 507 LNAFLLPIK 515 +K Sbjct: 288 AFCKFWGLK 296 >3D54-D nrPDB Length = 213 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 44/171 (25%), Positives = 72/171 (42%), Gaps = 28/171 (16%) Query: 65 KEQGFRAIIISGG--------PNSVYAEDAPWFDPA-IFTIGKPVLGICYGMQ---MMNK 112 K + II+ GG P +V A + F+ A GK ++GIC G Q M Sbjct: 38 KLDDYELIILPGGFSYGDYLRPGAVAAREKIAFEIAKAAERGKLIMGICNGFQILIEMGL 97 Query: 113 VFGGTVHKKSVRED-GVFNISVDNTCSLFRGL---QKEEVVLLTHG-------DSVDKVA 161 + G + S + ++ V+N + F ++ + + HG D V+ V Sbjct: 98 LKGALLQNSSGKFICKWVDLIVENNDTPFTNAFEKGEKIRIPIAHGFGRYVKIDDVNVVL 157 Query: 162 DGFKVVARSGNIVAGIANESKKLYGAQFHP-----EVGLTENGKVILKNFL 207 K V S +AG+ NES ++G HP E+ E+GK + ++ L Sbjct: 158 RYVKDVNGSDERIAGVLNESGNVFGLMPHPERAVEELIGGEDGKKVFQSIL 208 >2H2W-A nrPDB Length = 312 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 33/154 (21%), Positives = 55/154 (35%), Gaps = 17/154 (11%) Query: 54 IFPLETPAFAIKEQGFRAIIISGGPNSV---YAEDAPWFDPAIFTIGK----PVLGICYG 106 I T A+K++ F II+G P + D I + + IC+ Sbjct: 97 ILKFYTTFSAVKDRKFDGFIITGAPVELLPFEEVDYWEELTEIMEWSRHNVYSTMFICWA 156 Query: 107 MQM-MNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHG-------DSVD 158 Q + +G ++ + GV+ V LFRG H + +D Sbjct: 157 AQAGLYYFYGIPKYELPQKLSGVYKHRVAKDSVLFRGHDDFF--WAPHSRYTEVKKEDID 214 Query: 159 KVADGFKVVARSGNIVAGIANESKKLYGAQFHPE 192 KV + + V +AN+S++ HPE Sbjct: 215 KVPELEILAESDEAGVYVVANKSERQIFVTGHPE 248 >5U6R-A nrPDB Length = 545 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 59/192 (30%), Gaps = 51/192 (26%) Query: 67 QGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKS---- 122 +G AI++ GG E P LGIC GMQ+ + V Sbjct: 342 KGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANS 401 Query: 123 ------------------VREDGVFNISVDN-----------------TCSLFRGLQKEE 147 E+G + + SL R L Sbjct: 402 TEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQCQLVDDSLVRQLYNAP 461 Query: 148 VVLLTH-------GDSVDKVAD-GFKVVARSGN--IVAGIANESKKLY-GAQFHPEVGLT 196 ++ H + ++ D G +V RSG+ +V I + + QFHPE T Sbjct: 462 TIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTST 521 Query: 197 E-NGKVILKNFL 207 +G + F+ Sbjct: 522 PRDGHPLFAGFV 533 >6DG3-A nrPDB Length = 286 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 37/194 (19%), Positives = 59/194 (30%), Gaps = 47/194 (24%) Query: 237 SKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKV 296 +V V SGG+DST+ + L ++ V AV ++ E ++LG V+ Sbjct: 19 QRVTVAFSGGIDSTLVLKMALDVLGRDNVTAVVANSELFTDEEFDKAMSLAEELGANVQG 78 Query: 297 INAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMN 356 + D +K LN Sbjct: 79 T-TLDYLSDDHIKNNTPDSWYYAKKMFYSRLND--------------------------- 110 Query: 357 LKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHND--TELIRKLREEGKVIEPLKDF 414 I + + A+ +IK ND L + + + DF Sbjct: 111 -----------------IAANNGSAAVLDGMIKNDENDYRPGLKARSEAGARSLLQEADF 153 Query: 415 HKDEVRILGRELGL 428 K +VR L +ELGL Sbjct: 154 FKTDVRALAQELGL 167 >2NV0-A nrPDB Length = 196 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 50/148 (33%), Gaps = 30/148 (20%) Query: 68 GFRAIIISGGPNSVYAE--DAPWFDPAIFTI---GKPVLGICYGMQMMNKVFGGTVHKKS 122 +I+ GG ++ D F + GKP+ G C G+ ++ K G Sbjct: 38 EVDGLILPGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAG----SD 93 Query: 123 VREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFK-VVARSGNIVAG----- 176 G+ N+ V+ F ++ + + F V R+ +I+ Sbjct: 94 NPHLGLLNVVVERNS--FGRQVDSFEA----DLTIKGLDEPFTGVFIRAPHILEAGENVE 147 Query: 177 ---------IANESKKLYGAQFHPEVGL 195 +A + + G FHPE+ Sbjct: 148 VLSEHNGRIVAAKQGQFLGCSFHPELTE 175 >2W7T-A nrPDB Length = 273 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 30/199 (15%), Positives = 55/199 (27%), Gaps = 45/199 (22%) Query: 44 RVRELFVQSEIFPLETPAFAIKEQ-GFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLG 102 R+ L+V SE A K G I + GG + + P G Sbjct: 42 RLDILYVDSEELEGPNADEARKALLGCDGIFVPGGFGNRGVDGKCAAAQVARMNNIPYFG 101 Query: 103 ICYGMQMMNKVFGGTV---HKKSVREDGVFN-------------------------ISVD 134 +C GMQ+ V + E + + + Sbjct: 102 VCLGMQVAVIELSRNVVGWSDANSEEFNKESTHQVVRIMDCDRNKMGANMHLGACDVYIV 161 Query: 135 NTCSLFRGLQKEEV-VLLTHGDSVDKVADGFKVVARSGNIVAGIANESKK---------- 183 S+ + + V+ H + F+ + ++G ++ + + + Sbjct: 162 EKSSIMAKIYSKSNIVVERHRHRYEVNTAYFEDLRKAGLCISAVTDPTFSSRCRVEAVEN 221 Query: 184 -----LYGAQFHPEVGLTE 197 QFHPE T Sbjct: 222 PSLRFFLAVQFHPEFISTP 240 >3DPI-A nrPDB Length = 285 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 78/235 (33%), Gaps = 45/235 (19%) Query: 213 CSGTFTVQNRELE---CIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVH 269 S TF ++ + + G ++ +SGG+DS+ L A+ E++ A Sbjct: 20 VSPTFDARDEAERRIGFVADYLRTAGLRACVLGISGGIDSSTAGRLAQLAV--ERLRASG 77 Query: 270 IDNGF----MRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISK 325 D F + +A + L + A T T+ + ++ Sbjct: 78 YDARFVAMRLPYGAQHDEADARRALA----FVRADE-----TLTVDVKPAADAMLAALAA 128 Query: 326 TLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKA 385 ++ ++G N+K E +AQ ++ + Sbjct: 129 GGLAYLDHAQQDFVLG--------------NIKARERMIAQ----------YAVAGARNG 164 Query: 386 ELIKTHH---NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 +I T H + K + G + PL K VR L R LG E LV + P Sbjct: 165 VVIGTDHAAESVMGFFTKFGDGGADVLPLAGLTKRRVRALARMLGADEPLVLKTP 219 >2HMA-A nrPDB Length = 376 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 10/78 (12%) Query: 236 TSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHI-------DNGFMRKRES-QSVEEAL 287 ++V+V +SGGVDS+V LL VI + + +NG E + V Sbjct: 9 KTRVVVGMSGGVDSSVTALLLKEQGYD--VIGIFMKNWDDTDENGVCTATEDYKDVVAVA 66 Query: 288 KKLGIQVKVINAAHSFYN 305 ++GI +N +++ Sbjct: 67 DQIGIPYYSVNFEKEYWD 84 >5B4F-A nrPDB Length = 329 Score = 39.4 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 32/156 (20%), Positives = 53/156 (33%), Gaps = 19/156 (12%) Query: 221 NRELECIREIKERVGTSKVLVLLSGGVDS----TVCTALLNRALNQEQVIAVHIDNGFMR 276 IR + + +VLV +SGG DS V + L +A+ + + G Sbjct: 32 KETERAIRRHRMLLPGERVLVAVSGGKDSLALWDVLSRLGYQAVGLHIELGI----GEYS 87 Query: 277 KRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEK 336 KR + + ++ G+++ V++ ++ G L K Sbjct: 88 KRSLEVTQAFARERGLELLVVDLKEAYGFGVPELARLSGRVACSACGLS----------K 137 Query: 337 RKIIGDTFVKI-ANEVIGEMNLKPEEVFLAQGTLRP 371 R II V+ V NL E L L P Sbjct: 138 RYIINQVAVEEGFRVVATGHNLDDEAAVLFGNLLNP 173 >1Q7R-A nrPDB Length = 219 Score = 38.6 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 53/156 (33%), Gaps = 25/156 (16%) Query: 68 GFRAIIISGGPNSVYAEDAPW-----FDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKS 122 G +++ GG ++ GKP+ G C G+ ++ K G Sbjct: 60 GLDGLVLPGGESTTMRRLIDRYGLMEPLKQFAAAGKPMFGTCAGLILLAKRIVGY----D 115 Query: 123 VREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDK-----VADGFKVVARSGNIVAGI 177 G+ +I+V+ F ++ L+ D + V A G V Sbjct: 116 EPHLGLMDITVERNS--FGRQRESFEAELSIKGVGDGFVGVFIRAPHIVEAGDGVDVLAT 173 Query: 178 ANES------KKLYGAQFHPEVGLTENGKVILKNFL 207 N+ + G FHPE+ + +++ FL Sbjct: 174 YNDRIVAARQGQFLGCSFHPELT---DDHRLMQYFL 206 >5HUH-A nrPDB Length = 307 Score = 38.6 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 87/273 (31%), Gaps = 52/273 (19%) Query: 212 GCSGTFTVQNRELECIREIKERVGTSKV----LVLLSGGVDSTVCTALLNRALNQEQVIA 267 G + Q + + +K + ++ +SGG DST+ L A+ + Sbjct: 45 GVKASIDPQEEIRKTVDFLKAYLRKHSFLKTYVLGISGGQDSTLAGKLAQMAIAE----- 99 Query: 268 VHIDNGFMRKRESQSVEEALK---KLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRIS 324 +R+ S + + G+Q +A + ++ + Sbjct: 100 -------LREETSDQAYQFIAVRLPYGVQADEADAQKALAFIAPDQTLTINIKAAVDGQV 152 Query: 325 KTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGK 384 + L V+I++ + N+K + ++Q + Sbjct: 153 EALQAAG-------------VEISD--FNKGNIKARQRMISQYAI----------AGQMA 187 Query: 385 AELIKTHH---NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPG- 440 +I T H N T K + G I PL +K + + L + LG L + P Sbjct: 188 GAVIGTDHAAENITGFFTKFGDGGADILPLFRLNKRQGKALLKVLGADAALYEKVPTADL 247 Query: 441 ----PGLAIRVICAEEPYICKDFPETNNILKIV 469 PGLA V D+ E I K+ Sbjct: 248 EDQKPGLADEVALGVTYQDIDDYLEGKLISKVA 280 >5U03-A nrPDB Length = 591 Score = 38.6 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 26/75 (34%), Gaps = 7/75 (9%) Query: 51 QSEIFPLETPAFAIKEQ-------GFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGI 103 +++ P+ + ++ +++ GG E KP LG+ Sbjct: 339 SADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGV 398 Query: 104 CYGMQMMNKVFGGTV 118 C GMQ+ F V Sbjct: 399 CLGMQLAVVEFSRNV 413 >4XFJ-A nrPDB Length = 408 Score = 38.2 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 45/208 (21%), Positives = 80/208 (38%), Gaps = 40/208 (19%) Query: 236 TSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSV--EEALKKLGIQ 293 + +V++ SGG+D++V + + + +E V+AV ID G + E V + AL ++ Sbjct: 10 SERVILAYSGGLDTSVAISWIGKETGRE-VVAVAIDLG--QGGEDMEVVRQRALDCGAVE 66 Query: 294 VKVINAAHSFYNGTTTLPI-SDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVI 352 VI+A F N I S+ R + L+ R +I VK A E Sbjct: 67 SIVIDARDEFANDYCVPAIQSNALYMDRYPLVSALS--------RPLIVKHLVKAAREHG 118 Query: 353 GEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLK 412 GT+ A + ++ L L +V+ P++ Sbjct: 119 --------------GTIV------AHGCTGKGNDQVRFEVGFASLAPDL----EVLAPVR 154 Query: 413 DF--HKDEVRILGRELGLPEELVSRHPF 438 D+ +++ E +P + R PF Sbjct: 155 DYAWTREKAIAFAEENNIPINVTKRSPF 182 >3L18-A nrPDB Length = 168 Score = 37.8 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 36/108 (33%), Gaps = 14/108 (12%) Query: 58 ETPAFAIKEQGFRAIIISGG--PNSVYAEDAPW-FDPAIFTIGKPVLGICYGMQMM--NK 112 + + F A+++ GG P V + +F KPV IC+G Q++ K Sbjct: 53 DLTFEEVDPDEFDALVLPGGKAPEIVRLNEKAVMITRRMFEDDKPVASICHGPQILISAK 112 Query: 113 VFGGTVH------KKSVREDGVFNIS---VDNTCSLFRGLQKEEVVLL 151 V G + V G I V + + + + Sbjct: 113 VLKGRRGTSTITIRDDVINAGAEWIDAEVVVDGNWVSSRHPGDLYAWM 160 >1VCN-A nrPDB Length = 550 Score = 37.8 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 33/106 (31%), Gaps = 4/106 (3%) Query: 44 RVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGI 103 RV +V +E A ++ I++ GG E P LGI Sbjct: 333 RVEVKWVDAESLEAADLDEAFRD--VSGILVPGGFGVRGIEGKVRAAQYARERKIPYLGI 390 Query: 104 CYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVV 149 C G+Q+ F V ++ + + ++ V Sbjct: 391 CLGLQIAVIEFARNV--AGLKGANSTEFDPHTPHPVIDLMPEQLEV 434 >3FIU-A nrPDB Length = 249 Score = 37.8 bits (86), Expect = 0.017, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 80/235 (34%), Gaps = 47/235 (20%) Query: 212 GCSGTFTVQNRELECIREIKERVGT---SKVLVLLSGGVDSTVCTALLNRALNQEQVIAV 268 F+ + + + + + ++ LSGG+DS V +L + + + Sbjct: 2 KIVKDFSPKEYSQKLVNWLSDSCMNYPAEGFVIGLSGGIDSAVAASLAVKTGLPTTALIL 61 Query: 269 HIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLN 328 DN + Q +++AL+ + + +N H + + + + Sbjct: 62 PSDN-----NQHQDMQDALELIEM----LNIEHYTIS----------IQPAYEAFLASTQ 102 Query: 329 MTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELI 388 T+ + R+++ + G + ++L + +I Sbjct: 103 SFTNLQNNRQLV----------IKGNAQARLRMMYL------------YAYAQQYNRIVI 140 Query: 389 KTHHNDT---ELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPG 440 T + K + I PL + K +V LG+ L +P+ ++ + P G Sbjct: 141 GTDNACEWYMGYFTKFGDGAADILPLVNLKKSQVFELGKYLDVPKNILDKAPSAG 195 >4ZDJ-A nrPDB Length = 587 Score = 37.5 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 26/82 (31%), Gaps = 3/82 (3%) Query: 68 GFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDG 127 ++I GG E G PVLG+C G+Q + +V + Sbjct: 358 DVHGVLIPGGFGIRGIEGKIGAIAYARARGLPVLGLCLGLQCIVIEAARSVGLTNA---N 414 Query: 128 VFNISVDNTCSLFRGLQKEEVV 149 D + + +E + Sbjct: 415 SAEFDPDTPDPVIATMPDQEEI 436 >2DER-A nrPDB Length = 380 Score = 37.5 bits (85), Expect = 0.022, Method: Composition-based stats. Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 10/81 (12%) Query: 238 KVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRE--------SQSVEEALKK 289 KV+V +SGGVDS+V LL + QV + + N E + K Sbjct: 19 KVIVGMSGGVDSSVSAWLLQQQG--YQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDK 76 Query: 290 LGIQVKVINAAHSFYNGTTTL 310 LGI++ +N A +++ L Sbjct: 77 LGIELHTVNFAAEYWDNVFEL 97 >1OI4-A nrPDB Length = 193 Score = 36.7 bits (83), Expect = 0.037, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 35/120 (29%), Gaps = 8/120 (6%) Query: 55 FPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTI---GKPVLGICYGMQMMN 111 ++ + F A+++ GG + Y F GKPV IC+G Q++ Sbjct: 73 VTIDKSIDEVTPAEFDALLLPGGHSPDYLRGDNRFVTFTRDFVNSGKPVFAICHGPQLL- 131 Query: 112 KVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSG 171 V + I +EVV+ + D R Sbjct: 132 --ISADVIRGRKLTAVKPIIIDVKNAG--AEFYDQEVVVDKDQLVTSRTPDDLPAFNREA 187 >2VDJ-A nrPDB Length = 301 Score = 36.3 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 49/160 (30%), Gaps = 25/160 (15%) Query: 63 AIKEQGFRAIIISGGP-------NSVYAEDAPWFDPAIFTIGKPVLGICYGMQM-MNKVF 114 I+ + F +II+G P Y E+ T L IC+G Q + + Sbjct: 94 DIENEKFDGLIITGAPVETLSFEEVDYWEELKRIMEYSKTNVTSTLHICWGAQAGLYHHY 153 Query: 115 GGTVHKKSVREDGVFNISVDN---------TCSLFRGLQKEEVVLLTHGDSVDKVADGFK 165 G + + GVF V F + V + V ++ Sbjct: 154 GVQKYPLKEKMFGVFEHEVREQHVKLLQGFDELFFAVHSRHTEVRESDIREVKEL--TLL 211 Query: 166 VVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKN 205 + + I E ++++ G +E LK Sbjct: 212 ANSEEAGVHLVIGQEGRQVFAL------GHSEYSCDTLKQ 245 >2VKT-A nrPDB Length = 289 Score = 35.9 bits (81), Expect = 0.054, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 16/45 (35%) Query: 70 RAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVF 114 I++ GG T P LG+C GMQ+ F Sbjct: 92 DGILVPGGFGIRGTLGKLQAISWARTKKIPFLGVCLGMQLAVIEF 136 >2PZ8-A nrPDB Length = 284 Score = 35.9 bits (81), Expect = 0.064, Method: Composition-based stats. Identities = 48/303 (15%), Positives = 97/303 (32%), Gaps = 55/303 (18%) Query: 215 GTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRAL-------NQEQVIA 267 ++ R + +++ ++ G ++ +SGG DST+ L A+ IA Sbjct: 19 PKAEIRKRV-DFLKDYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVEEIRNEGGNATFIA 77 Query: 268 VHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTL 327 V + + + ++A +L +Q + + +F +T S++ Sbjct: 78 VR-----LPYKVQKDEDDA--QLALQFIQADQSVAFDIASTVDAFSNQYENLLDESL--- 127 Query: 328 NMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAEL 387 T N+ + ++ + G L+ G Sbjct: 128 ---TD---------------FNKGNVKARIRMVTQYAIGG--------QKGLLVIGTDHA 161 Query: 388 IKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPG-----PG 442 + T K + G + PL K + R L +ELG E L + P PG Sbjct: 162 AEA---VTGFFTKFGDGGADLLPLTGLTKRQGRALLQELGADERLYLKMPTADLLDEKPG 218 Query: 443 LAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQIT 502 A D+ E + AD + ++K +T+ + + + Sbjct: 219 QADETELGITYDQLDDYLEGKTV---PADVAEKIEKRYTVSEHKRQVPASMFDDWWKLAA 275 Query: 503 SLH 505 +L Sbjct: 276 ALE 278 >2VRN-A nrPDB Length = 190 Score = 35.9 bits (81), Expect = 0.067, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 24/49 (48%), Gaps = 4/49 (8%) Query: 62 FAIKEQGFRAIIISGG---PNSVY-AEDAPWFDPAIFTIGKPVLGICYG 106 ++ + +++ GG P+ + E A F ++ GKP+ IC+G Sbjct: 69 SEVQVSDYDGLLLPGGTVNPDKLRLEEGAMKFVRDMYDAGKPIAAICHG 117 >4L8Y-C nrPDB Length = 312 Score = 35.9 bits (81), Expect = 0.067, Method: Composition-based stats. Identities = 26/159 (16%), Positives = 54/159 (33%), Gaps = 33/159 (20%) Query: 67 QGFRAIIISGG----PNSVYAEDAPWFDPAIFTIGK-----PVLGICYGMQMMNKVFGGT 117 + ++ GG +S Y++ A F PV G G +++ + G Sbjct: 83 KSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPVWGTALGFELLTLLTSGE 142 Query: 118 VHKKSVREDGVF----NISVDNTCSLFRGLQKEEVVLL--------THGDSVD------- 158 + G+ LF+ +E + L +H S+ Sbjct: 143 LLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEELMKSLATEPLTENSHQWSITTENFTAN 202 Query: 159 -KVADGFKVVARSGN----IVAGIANESKKLYGAQFHPE 192 K+ ++V++ + + V+ + +Y Q+HPE Sbjct: 203 KKLKKFYRVLSTNTDGYNKFVSTMEAYDFPIYATQWHPE 241 >1JGT-A nrPDB Length = 513 Score = 34.8 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 39/104 (37%), Gaps = 3/104 (2%) Query: 240 LVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKK--LGIQVKVI 297 LV+LSGG+DS+ A +RA + +++ D RE+++V + L+ I + Sbjct: 245 LVVLSGGIDSSGVAACAHRAAGELDTVSMGTDTS-NEFREARAVVDHLRTRHREITIPTT 303 Query: 298 NAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIG 341 D D L E+R + G Sbjct: 304 ELLAQLPYAVWASESVDPDIIEYLLPLTALYRALDGPERRILTG 347 >1KA9-H nrPDB Length = 200 Score = 34.8 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 29/187 (15%), Positives = 53/187 (28%), Gaps = 31/187 (16%) Query: 27 AVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISG----GPNSVY 82 +++D G+ + + + S + A +++ G G Sbjct: 4 KALLIDYGSGNLRSAAKALEAAG-FSVAVAQDPKAHE----EADLLVLPGQGHFGQVMRA 58 Query: 83 AEDAPWFDP--AIFTIGKPVLGICYGMQMM---------NKVFG---GTVHK---KSVRE 125 +++ + + G P LGIC GMQ++ + G G V + V + Sbjct: 59 FQESGFVERVRRHLERGLPFLGICVGMQVLYEGSEEAPGVRGLGLVPGEVRRFRAGRVPQ 118 Query: 126 DGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLY 185 G + F L G + + L Sbjct: 119 MGWNALEF---GGAFAPLTGRHFYFAN-SYYGPLTPYSLGKGEYEGTPFTALLAKE-NLL 173 Query: 186 GAQFHPE 192 QFHPE Sbjct: 174 APQFHPE 180 >4WXY-B nrPDB Length = 228 Score = 34.4 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 53/156 (33%), Gaps = 25/156 (16%) Query: 68 GFRAIIISGGPNSVYAEDAPW-----FDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKS 122 G +++ GG ++ GKP+ G C G+ ++ K G Sbjct: 69 GLDGLVLPGGESTTMRRLIDRYGLMEPLKQFAAAGKPMFGTCAGLILLAKRIVGY----D 124 Query: 123 VREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDK-----VADGFKVVARSGNIVAGI 177 G+ +I+V+ F ++ L+ D + V A G V Sbjct: 125 EPHLGLMDITVERNS--FGRQRESFEAELSIKGVGDGFVGVFIRAPHIVEAGDGVDVLAT 182 Query: 178 ANES------KKLYGAQFHPEVGLTENGKVILKNFL 207 N+ + G F+PE+ + +++ FL Sbjct: 183 YNDRIVAARQGQFLGCSFNPELT---DDHRLMQYFL 215 >1K9V-F nrPDB Length = 201 Score = 34.4 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 43/122 (35%), Gaps = 27/122 (22%) Query: 100 VLGICYGMQMMNKV------------FGGTVHK---KSVREDGVFNISVDNTCSLFRGLQ 144 V+G+C GMQ++ + G V K + + G + +T Sbjct: 80 VVGVCLGMQLLFEESEEAPGVKGLSLIEGNVVKLRSRRLPHMGWNEVIFKDT------FP 133 Query: 145 KEEVVLLTHGDSVDKVADGFKVVARSGNIVAGI--ANESKKLYGAQFHPEVGLTENGKVI 202 + + V + V+ + A ++ G QFHPE ++ G+ + Sbjct: 134 NGYYYFVH---TYRAVCEEEHVLGTTEYDGEIFPSAVRKGRILGFQFHPEKS-SKIGRKL 189 Query: 203 LK 204 L+ Sbjct: 190 LE 191 >2PG3-A nrPDB Length = 232 Score = 34.4 bits (77), Expect = 0.17, Method: Composition-based stats. Identities = 18/63 (28%), Positives = 30/63 (47%), Gaps = 2/63 (3%) Query: 235 GTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQV 294 G + +V+ SGG DST C L+ + + V + D G + E + +E +KLG Sbjct: 1 GMKRAVVVFSGGQDSTTC--LIQALQDYDDVHCITFDYGQRHRAEIEVAQELSQKLGAAA 58 Query: 295 KVI 297 + Sbjct: 59 HKV 61 >2ISS-D nrPDB Length = 208 Score = 34.0 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 54/167 (32%), Gaps = 28/167 (16%) Query: 45 VRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNS-----VYAEDAPWFDPAIFTIGKP 99 + +L V++ I L + +I+ GG ++ + D G P Sbjct: 39 LHKLGVETLIVKLPEQLDMV-----DGLILPGGESTTMIRILKEMDMDEKLVERINNGLP 93 Query: 100 VLGICYGMQMMNKVFGGTVHKKSVREDGVFNISV--------DNTCSLFRGLQ----KEE 147 V C G+ ++ K + S + GV +I+V + F + Sbjct: 94 VFATCAGVILLAK----RIKNYSQEKLGVLDITVERNAYGRQVESFETFVEIPAVGKDPF 149 Query: 148 VVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVG 194 + + + +++A + + + FHPE+ Sbjct: 150 RAIFIRAPRIVETGKNVEILATYDYDPVLV--KEGNILACTFHPELT 194 >4OFW-A nrPDB Length = 387 Score = 33.6 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 23/63 (36%), Gaps = 3/63 (4%) Query: 54 IFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTI---GKPVLGICYGMQMM 110 F L T + + A++I GG Y + KPV IC+G Q++ Sbjct: 258 TFALTTNFDDLVSSSYDALVIPGGRAPEYLALNEHVLNIVKEFMNSEKPVASICHGQQIL 317 Query: 111 NKV 113 Sbjct: 318 AAA 320 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 21/62 (33%), Gaps = 3/62 (4%) Query: 55 FPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTI---GKPVLGICYGMQMMN 111 F L + + ++I GG Y + GKP+ IC+G ++ Sbjct: 66 FTLNATFDEVDLSKYDGLVIPGGRAPEYLALTASVVELVKEFSRSGKPIASICHGQLILA 125 Query: 112 KV 113 Sbjct: 126 AA 127 >3A2K-A nrPDB Length = 464 Score = 32.8 bits (73), Expect = 0.51, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 20/117 (17%) Query: 227 IREIKERVGTSK-------VLVLLSGGVDSTVCTALLNRALN-----QEQVIAVHIDNGF 274 I +++ + + V+V +SGG DS ALL+ L+ + QVIA H+D+ Sbjct: 2 IDKVRAFIHRHQLLSEGAAVIVGVSGGPDS---LALLHVFLSLRDEWKLQVIAAHVDH-M 57 Query: 275 MRKRESQSVEEALKKLGIQVKVI----NAAHSFYNGTTTLPISDEDRTPRKRISKTL 327 R RES+ E +K+ ++ +++ + + L + R R R L Sbjct: 58 FRGRESEEEMEFVKRFCVERRILCETAQIDVPAFQRSAGLGAQEAARICRYRFFAEL 114 >1Q19-A nrPDB Length = 503 Score = 32.5 bits (72), Expect = 0.71, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 26/57 (45%), Gaps = 4/57 (7%) Query: 237 SKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQ 293 V + LSGG+DS++ TAL +R + ++ G E + ++ LG Sbjct: 239 DTVGIPLSGGLDSSLVTALASRHFKKLNTYSI----GTELSNEFEFSQQVADALGTH 291 >2E21-A nrPDB Length = 317 Score = 32.5 bits (72), Expect = 0.72, Method: Composition-based stats. Identities = 21/98 (21%), Positives = 42/98 (42%), Gaps = 5/98 (5%) Query: 235 GTSKVLVLLSGGVDSTVCTALLNRA---LNQEQVIAVHIDNGFMRKRES--QSVEEALKK 289 G +VL+ SGGVDS V T +L + + ++V H ++ E + +E K+ Sbjct: 23 GERRVLIAFSGGVDSVVLTDVLLKLKNYFSLKEVALAHFNHMLRESAERDEEFCKEFAKE 82 Query: 290 LGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTL 327 +++ V + + + + R R + K + Sbjct: 83 RNMKIFVGKEDVRAFAKENRMSLEEAGRFLRYKFLKEI 120 >1G2I-A nrPDB Length = 166 Score = 32.1 bits (71), Expect = 0.93, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 40/108 (37%), Gaps = 14/108 (12%) Query: 58 ETPAFAIKEQGFRAIIISGG--PNSVYAEDAPW-FDPAIFTIGKPVLGICYGMQMM--NK 112 + + + F A+++ GG P V + +F+ GKPV IC+G Q++ Sbjct: 51 DLTFDKVNPEEFDALVLPGGRAPERVRLNEKAVSIARKMFSEGKPVASICHGPQILISAG 110 Query: 113 VFGGTVH------KKSVREDGVFNIS---VDNTCSLFRGLQKEEVVLL 151 V G K + GV + V + + + + + Sbjct: 111 VLRGRKGTSYPGIKDDMINAGVEWVDAEVVVDGNWVSSRVPADLYAWM 158 >2VJT-B nrPDB Length = 161 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 12/58 (20%), Positives = 26/58 (44%) Query: 73 IISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFN 130 +++G P+ + ++G P+ G+Q M +V GG V + +E ++ Sbjct: 96 MLAGDPSILDERVLNGLKETYNSLGVPIAATVGGIQAMKEVVGGLVGPDAAKEASIYF 153 >6C8Q-A nrPDB Length = 275 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 44/233 (18%), Positives = 73/233 (31%), Gaps = 41/233 (17%) Query: 212 GCSGTFTVQNRELECIREIKERVGTS----KVLVLLSGGVDSTVCTALLNRALNQEQVIA 267 G T + + I +K + ++ +SGG DST+ L A+ + Sbjct: 13 GVLPTIDPKEEVRKSIDFLKAYLTKHPFLKTFVLGISGGQDSTLAGRLAQLAMTE----- 67 Query: 268 VHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTL 327 MR+ + + I++ A I + Sbjct: 68 -------MREETGDMSYQF---IAIRLPYGEQADEADAQAALAFIQPDVSLRVDIKPAVD 117 Query: 328 NMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAEL 387 M S E I D + N+K + + Q ++ + Sbjct: 118 AMVGSLENAGVQISD---------FNKGNMKARQRMITQ----------YAVAGENAGAV 158 Query: 388 IKTHH---NDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHP 437 I T H N T K + G I PL +K + + L +ELG PE L + P Sbjct: 159 IGTDHAAENVTAFFTKYGDGGADILPLFRLNKRQGKALLKELGAPEALYLKIP 211 >6NPU-A nrPDB Length = 298 Score = 31.3 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 34/149 (22%), Positives = 56/149 (37%), Gaps = 10/149 (6%) Query: 520 QGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVN--RVVYIFGPPVKEPPTDVTP 577 +G + YS + + E E FL + + +V + G +EPP + Sbjct: 44 EGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA--VMKEIKHPNLVQLLGVCTREPPFYIIT 101 Query: 578 TFLTTG-VLSTLRQADFEAHNILRESGYAGKISQMPVILTP---LHFDRDPLQKQPSCQR 633 F+T G +L LR+ + + N + A +IS L +H D Sbjct: 102 EFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH 161 Query: 634 SVVIRTFITSDFMTGI--PATPGNEIPVE 660 V + F S MTG A G + P++ Sbjct: 162 LVKVADFGLSRLMTGDTYTAHAGAKFPIK 190 >4XEY-B nrPDB Length = 408 Score = 31.3 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 34/149 (22%), Positives = 56/149 (37%), Gaps = 10/149 (6%) Query: 520 QGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVN--RVVYIFGPPVKEPPTDVTP 577 +G + YS + + E E FL + + +V + G +EPP + Sbjct: 143 EGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA--VMKEIKHPNLVQLLGVCTREPPFYIIT 200 Query: 578 TFLTTG-VLSTLRQADFEAHNILRESGYAGKISQMPVILTP---LHFDRDPLQKQPSCQR 633 F+T G +L LR+ + + N + A +IS L +H D Sbjct: 201 EFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENH 260 Query: 634 SVVIRTFITSDFMTGI--PATPGNEIPVE 660 V + F S MTG A G + P++ Sbjct: 261 LVKVADFGLSRLMTGDTYTAHAGAKFPIK 289 >6FYQ-A nrPDB Length = 484 Score = 31.3 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 48/134 (35%), Gaps = 1/134 (0%) Query: 299 AAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDT-FVKIANEVIGEMNL 357 AA + ++ L+ + + +I+GD FV + V N Sbjct: 351 AAAVALKNIAIIKEERLVENSKRMGDALLHGLKKVKNRLEIVGDVRFVGLLGAVELMQNP 410 Query: 358 KPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKD 417 + F + + P +IE+ + + H N L L K ++ L + + Sbjct: 411 ATNKPFSSNLQVAPKVIEALHELGVICRSVTYDHTNIICLAPPLIINQKQVDKLVEVIYE 470 Query: 418 EVRILGRELGLPEE 431 + + ++LG+ E Sbjct: 471 AILKVQQQLGIKAE 484 >2FO0-A nrPDB Length = 495 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 5/99 (5%) Query: 520 QGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVN--RVVYIFGPPVKEPPTDVTP 577 +G + YS + + E E FL + + +V + G +EPP + Sbjct: 235 EGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA--VMKEIKHPNLVQLLGVCTREPPFYIIT 292 Query: 578 TFLTTG-VLSTLRQADFEAHNILRESGYAGKISQMPVIL 615 F+T G +L LR+ + + N + A +IS L Sbjct: 293 EFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL 331 >3BL5-A nrPDB Length = 219 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 34/192 (17%), Positives = 64/192 (33%), Gaps = 20/192 (10%) Query: 236 TSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVK 295 K +V+ SGG DST C + E+V V +E + + +KLG++ Sbjct: 3 KEKAIVVFSGGQDSTTCLLWALKEF--EEVETVTFHYNQRHSQEVEVAKSIAEKLGVKNH 60 Query: 296 VINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEM 355 +++ + L +D + + + + G V + Sbjct: 61 LLDMSLLNQLAPNALTRNDIEIEVKDGELPSTF----------VPGRNLV--FLSFASIL 108 Query: 356 NLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFH 415 + + G D S + E +K+ + L + + + PL + Sbjct: 109 AYQIGARHIITGVCETDF----SGYPDCRDEFVKSCNVTVNLA--MEKPFVIHTPLMWLN 162 Query: 416 KDEVRILGRELG 427 K E L ELG Sbjct: 163 KAETWKLADELG 174 >2YAX-A nrPDB Length = 318 Score = 31.3 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 16/46 (34%) Query: 156 SVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKV 201 + F++ A G V + G Q H ++G+ G Sbjct: 12 ELKNEPKTFEMFASVGPKVCMVTARHPGFVGFQNHIQIGILPFGNR 57 >2C5S-A nrPDB Length = 413 Score = 30.9 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 12/21 (57%), Positives = 15/21 (71%) Query: 238 KVLVLLSGGVDSTVCTALLNR 258 KV+VLLSGG+DS V L + Sbjct: 189 KVMVLLSGGIDSPVAAYLTMK 209 >2D1S-A nrPDB Length = 548 Score = 30.9 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 33/89 (37%), Gaps = 7/89 (7%) Query: 158 DKVADGFKVVARSGNIVAGIANESKKLYGAQFHP-----EVGLTENGKVILKNFLYDIAG 212 + G ++ NIV ++ +YG Q P V +G + Y I G Sbjct: 204 TGLPKGVQLT--HENIVTRFSHARDPIYGNQVSPGTAVLTVVPFHHGFGMFTTLGYLICG 261 Query: 213 CSGTFTVQNRELECIREIKERVGTSKVLV 241 + E ++ +++ TS +LV Sbjct: 262 FRVVMLTKFDEETFLKTLQDYKCTSVILV 290 >2GRE-A nrPDB Length = 349 Score = 30.9 bits (68), Expect = 2.1, Method: Composition-based stats. Identities = 40/279 (14%), Positives = 85/279 (30%), Gaps = 25/279 (8%) Query: 302 SFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKR-----KIIGDTFVKIANEVIGEMN 356 +F + + R + + T+ + + +G +I + ++ Sbjct: 30 NFIENYVSEWNVETKRNNKGALILTVKGKNDAQHRLLTAHVDTLGAMVKEIKPDGRLSLS 89 Query: 357 LKPEEVFLAQGTLRPDLIESASLVASG--KAELIKTH-HNDTELIRKLREEGKVIEPLKD 413 + + + ++ S+ +G H + D ++ + +V + Sbjct: 90 MIGGFRWNSVEGEYCEIETSSGKTYTGTILMHQTSVHVYKDAGEAKRDEKNIEVRIDERV 149 Query: 414 FHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFS 473 F DEVR LG E+G + VS P RV E YI + + I+ Sbjct: 150 FSADEVRELGIEVG---DFVSFDP--------RVQITESGYIKSRHLDDKVSVAILLKLI 198 Query: 474 ASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYS-YVCGI 532 ++ + L ++E S +G GD ++ Y I Sbjct: 199 KRLQDENVTLPYTTHFLISNNEEIGYGGNSNIPEETVEYLAVDMGALGDGQASDEYTVSI 258 Query: 533 SSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEP 571 +KD + + + + +I P Sbjct: 259 CAKDSSGPYH-----YALRKHLVELAKTNHIEYKVDIYP 292 >2QYG-A nrPDB Length = 452 Score = 30.5 bits (67), Expect = 2.7, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 21/48 (43%) Query: 218 TVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQV 265 T ++ L+CIR E +G K + + GG DS + R + Sbjct: 350 TPEHEVLDCIRACLEPMGPIKPCLPVPGGSDSAATLENVYRKVGSADF 397 >3SEZ-A nrPDB Length = 680 Score = 30.1 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 36/100 (36%), Gaps = 7/100 (7%) Query: 238 KVLVLLSGGVDSTVCTALLNRALNQE-----QVIAVHIDNGFMRKRESQSVEEALKKLGI 292 KV++ +SGG+DST + A+++E ++A + + + + + LG+ Sbjct: 363 KVVIGVSGGLDSTHALIVATHAMDREGRPRSDILAFALPGFATGEHTKNNAIKLARALGV 422 Query: 293 QVKVINAAH--SFYNGTTTLPISDEDRTPRKRISKTLNMT 330 I+ T P S ++ Sbjct: 423 TFSEIDIGDTARLMLHTIGHPYSVGEKVYDVTFENVQAGL 462 >3F4N-A nrPDB Length = 246 Score = 30.1 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 39/105 (37%), Gaps = 35/105 (33%) Query: 365 AQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRIL-- 422 A+GT+ PD +++A + A+ I H + E + +VRIL Sbjct: 22 ARGTIYPDPVQAAFIAEQAGADGITVH---------------LREDRRHITDRDVRILRQ 66 Query: 423 ------GRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPE 461 E+ + +E+ + + C +P+ C PE Sbjct: 67 TIQTRMNLEMAVTDEM------------VDIACDIKPHFCCLVPE 99 >5W1A-B nrPDB Length = 155 Score = 29.8 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 39/101 (38%), Gaps = 17/101 (16%) Query: 275 MRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPE 334 + KRE ++VE + +G + I+A + + P + + L T Sbjct: 4 VPKREVENVEFVFEVMGSPGEGIDAVD------LGDALRALNLNPTLALIEKLGGTKKRN 57 Query: 335 EKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIE 375 EK KI D F+ I ++V E QG D IE Sbjct: 58 EK-KIKLDEFLPIYSQVKKEKE---------QGC-YEDFIE 87 >3F7A-A nrPDB Length = 394 Score = 29.0 bits (63), Expect = 7.2, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 25/58 (43%), Gaps = 1/58 (1%) Query: 198 NGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTAL 255 G I ++ D+ C Q LE IR I++ + ++VL GV S AL Sbjct: 40 QGLQIFESEQPDLVICD-LRMPQIDGLELIRRIRQTASETPIIVLSGAGVMSDAVEAL 96 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.124 0.327 Lambda K H 0.267 0.0379 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,990,881 Number of Sequences: 36641 Number of extensions: 958490 Number of successful extensions: 3272 Number of sequences better than 10.0: 93 Number of HSP's better than 10.0 without gapping: 82 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 2982 Number of HSP's gapped (non-prelim): 181 length of query: 693 length of database: 10,336,785 effective HSP length: 104 effective length of query: 589 effective length of database: 6,526,121 effective search space: 3843885269 effective search space used: 3843885269 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 62 (28.6 bits)