BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P49591 (514 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4RQF-A nrPDB 1067 0.0 6BLJ-A nrPDB 478 e-135 3LSS-A nrPDB 453 e-128 6GIR-A nrPDB 448 e-126 3QO8-A nrPDB 424 e-119 6OTE-A nrPDB 381 e-106 2ZR2-A nrPDB 302 2e-82 2DQ3-A nrPDB 233 1e-61 6H9X-A nrPDB 212 3e-55 3ERR-A nrPDB 195 3e-50 1SER-A nrPDB 189 3e-48 1WLE-A nrPDB 179 2e-45 1NJ2-A nrPDB 47 2e-05 1NJ8-A nrPDB 45 5e-05 5UCM-A nrPDB 44 2e-04 3W3S-A nrPDB 40 0.002 5Z5E-A nrPDB 33 0.29 5XIG-A nrPDB 33 0.39 1LPD-A nrPDB 32 0.56 4NX9-A nrPDB 32 0.81 1ATI-A nrPDB 31 1.4 1B76-A nrPDB 31 1.6 5EXX-A nrPDB 30 2.3 4YYE-A nrPDB 30 3.5 5E2F-A nrPDB 29 4.4 5X2G-A nrPDB 28 7.1 5HXY-A nrPDB 28 9.8 >4RQF-A nrPDB Length = 522 Score = 1067 bits (2759), Expect = 0.0, Method: Compositional matrix adjust. Identities = 513/514 (99%), Positives = 514/514 (100%) Query: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC Sbjct: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 Query: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE Sbjct: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 Query: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF 180 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF Sbjct: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF 180 Query: 181 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL 240 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL Sbjct: 181 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL 240 Query: 241 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC 300 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC Sbjct: 241 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC 300 Query: 301 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH 360 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH Sbjct: 301 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH 360 Query: 361 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV 420 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV Sbjct: 361 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV 420 Query: 421 EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP 480 EFVHMLNATMCATTRTICAILENYQT+KGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP Sbjct: 421 EFVHMLNATMCATTRTICAILENYQTKKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP 480 Query: 481 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA 514 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA Sbjct: 481 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA 514 >6BLJ-A nrPDB Length = 485 Score = 478 bits (1231), Expect = e-135, Method: Compositional matrix adjust. Identities = 248/487 (50%), Positives = 335/487 (68%), Gaps = 30/487 (6%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 +LD++LFR KGG+P +IRE+Q +RF D LVD++++ D WR + +++ + S Sbjct: 9 MLDINLFREYKGGNPEIIRESQRRRFADVTLVDKVIELDEVWRATIGKLNHIKSFTGIIS 68 Query: 62 KTIGEKMKKKEPVGDDESVPENV-------LSFDDLTADALANLKVSQIKKVRLLIDEAI 114 K +G +MK K P+GDD +P+ V + + L +LA L +Q+KK+ I E Sbjct: 69 KEVGNRMKNKVPLGDDLELPKEVTDDVYALFTKEALEQGSLAKLNTNQLKKLSTYITEVH 128 Query: 115 LK-CDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDC-------TVRK 166 +K + E + E ER + L +IGN++H +V +S++ED +N + R+ G+ T K Sbjct: 129 IKNSEEEVKQKEKERDDVLLQIGNIVHETVVVSDNED-NNGIVRMVGNPRPKVDPETGYK 187 Query: 167 KYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTP 226 H+D++ + G E+G V G RGYFL G LV + AL YA+ L +GY+PIYTP Sbjct: 188 CLKHIDIMRKLGGLATEEGTQVGGGRGYFLLGDLVRMNLALQNYAIDFLAKKGYMPIYTP 247 Query: 227 FFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLR 286 FFM KE M++VAQLSQFDEELY V G+G ++KYLIATSEQPIAA H ++ Sbjct: 248 FFMTKEQMKKVAQLSQFDEELYTVTGEG---------EDKYLIATSEQPIAAFHLEKRFD 298 Query: 287 PEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIT 346 +LPIKY G+STCFR+EVG+HG+DT GIFRVHQFEKIEQFV +SP DNKSWEMF+EMI Sbjct: 299 ESELPIKYCGMSTCFRKEVGAHGKDTLGIFRVHQFEKIEQFVVTSPKDNKSWEMFDEMIG 358 Query: 347 TAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGS---GAFRELVSCSNCTDYQA 403 +E FYQSLGIPY +VNIVSG+LN+AA+KK DLEAWFPG+ +RELVSCSNCTDYQ Sbjct: 359 NSEAFYQSLGIPYRVVNIVSGALNNAAAKKFDLEAWFPGADEGNEYRELVSCSNCTDYQT 418 Query: 404 RRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPG 463 RRL ++YG++KK +VEF HMLN+T+ AT+RT+C I+ENYQT +G+ VPE L+ +M G Sbjct: 419 RRLEVKYGKSKKQGSEVEFCHMLNSTLTATSRTLCCIVENYQTPEGVNVPEVLQPYM--G 476 Query: 464 LQELIPF 470 + I F Sbjct: 477 GTKFIKF 483 >3LSS-A nrPDB Length = 484 Score = 453 bits (1166), Expect = e-128, Method: Compositional matrix adjust. Identities = 235/467 (50%), Positives = 310/467 (66%), Gaps = 18/467 (3%) Query: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 MVLD+ LFR + G + +IRE+Q +RF DP +VD +++AD +WRR +F + KL N+C Sbjct: 6 MVLDIQLFRDETGAN--IIRESQRRRFADPDIVDAIIEADKKWRRTQFLTEASKKLINIC 63 Query: 61 SKTIGEKMKKKEPVGDDESVPENV---LSFDDLTADALANLKVSQIKKVRLLIDEAILKC 117 SK +G K K KE GD +P V L + + L V Q+K++ + + + Sbjct: 64 SKAVGAKKKAKEADGDTSEIPPQVKEAYENGTLKGEQVEQLCVLQLKQLSKDLSDQVAGL 123 Query: 118 DAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMV 177 E +LE ER + + +GN+LH SVPI+ DE+ N V R +G+ T R K +HV ++ + Sbjct: 124 AKEAQQLEEERDKLMLNVGNILHESVPIAQDEETGNTVVRTFGNTTKRAKLNHVSIMERL 183 Query: 178 DGFEGEKGAV-VAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQE 236 + K +AG R Y LKG LV L+ AL+ Y+L L RGY P Y PFF+ ++VM E Sbjct: 184 GMMDTSKAVTSMAGGRSYVLKGGLVQLQVALVSYSLDFLVKRGYTPFYPPFFLNRDVMGE 243 Query: 237 VAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAG 296 VAQLSQFDEELY+V G G D+KYLIATSE PIAA HR W P+KYAG Sbjct: 244 VAQLSQFDEELYQVSGDG---------DKKYLIATSEMPIAAYHRGRWFTELKEPLKYAG 294 Query: 297 LSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLG 356 +STCFR+E G+HGRDT GIFRVHQF+KIEQFV SP +SW E+MITT+EEF +SLG Sbjct: 295 MSTCFRKEAGAHGRDTLGIFRVHQFDKIEQFVVCSPRQEESWRHLEDMITTSEEFNKSLG 354 Query: 357 IPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYG---QT 413 +PY +VNI SG+LN+AA+KK DLEAWFP SGAFRELVSCSNCTDYQ++ + RYG + Sbjct: 355 LPYRVVNICSGALNNAAAKKYDLEAWFPASGAFRELVSCSNCTDYQSQSVNCRYGPNLRG 414 Query: 414 KKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFM 460 + E+ HMLN T+CA TRT+C I ENYQTE+G+ +P+ L+ +M Sbjct: 415 TAAQNVKEYCHMLNGTLCAITRTMCCICENYQTEEGVVIPDVLRPYM 461 >6GIR-A nrPDB Length = 456 Score = 448 bits (1152), Expect = e-126, Method: Compositional matrix adjust. Identities = 234/483 (48%), Positives = 318/483 (65%), Gaps = 51/483 (10%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 ++D++LFR +KG +P +IRE+Q +RF +VD+++K D EWR+ +F D+ K N + Sbjct: 1 MVDINLFREEKGNNPEIIRESQRRRFASVEIVDEIIKLDKEWRQRQFEVDSFRKEFNKLN 60 Query: 62 KTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAER 121 K + + KKE E + + + D TA K +++++ A LK Sbjct: 61 KQVAQLKIKKEDAS--EIIQQTEKNKQDSTA------KEAEVREAY-----AALKA---- 103 Query: 122 IKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYS--------HVDL 173 L ++GNL+H SVP+ DE +N V ++WG+ K++S HVDL Sbjct: 104 ---------KLEQVGNLVHDSVPVDKDE-ANNLVIKLWGE----KRFSTPGLKLKNHVDL 149 Query: 174 VVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEV 233 V ++ + ++GA +AG+RG+FLKG + L QALI + L L RG+ + PFFMRK+V Sbjct: 150 VELLGIADTKRGAEIAGARGFFLKGDGLMLNQALINFGLTFLKKRGFTGLQPPFFMRKDV 209 Query: 234 MQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIK 293 M + AQL+QFDEELYKV G+G D+KYLIAT+EQP+ A H DEW+ P +LP++ Sbjct: 210 MAKCAQLAQFDEELYKVTGEG---------DDKYLIATAEQPLCAYHIDEWIHPTELPLR 260 Query: 294 YAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQ 353 YAG S+CFR+E GSHGRDT GIFRVHQFEKIEQF + P++N SWEM +EM+ +E+FYQ Sbjct: 261 YAGYSSCFRKEAGSHGRDTLGIFRVHQFEKIEQFCITGPNENASWEMLDEMMKNSEDFYQ 320 Query: 354 SLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQT 413 +L +PY IV+IVSG+LN AA+KK DLEAWFP S FRELVSCSNCTDYQARRL IRYGQ Sbjct: 321 ALKLPYQIVSIVSGALNDAAAKKYDLEAWFPSSETFRELVSCSNCTDYQARRLEIRYGQK 380 Query: 414 KKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKP 473 K ++VHMLN+T+ AT RTIC ILENYQ E G+ +PE L+ FM G + +PF K Sbjct: 381 KSNEQTKQYVHMLNSTLTATERTICCILENYQREDGVDIPEVLQPFM--GGETFLPF-KA 437 Query: 474 API 476 P+ Sbjct: 438 KPV 440 >3QO8-A nrPDB Length = 485 Score = 424 bits (1091), Expect = e-119, Method: Compositional matrix adjust. Identities = 240/519 (46%), Positives = 317/519 (61%), Gaps = 64/519 (12%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 +LD++ F V+KGGDP +I+ +Q+KR LVD+++ EW + RF D NK N Sbjct: 1 MLDINAFLVEKGGDPEIIKASQKKRGDSVELVDEIIAEYKEWVKLRFDLDEHNKKLNSVQ 60 Query: 62 KTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAER 121 K IG++ K KE DL A+ K+S KK E Sbjct: 61 KEIGKRFKAKEDA-------------KDLIAE---KEKLSNEKK--------------EI 90 Query: 122 IKLEAERFENLR----EIGNLLHPSVPISNDEDVDNKVERIWGDCTVRK----------- 166 I+ EAE +NLR ++GN++H SV S DE+ +N++ R W +K Sbjct: 91 IEKEAEADKNLRSKINQVGNIVHESVVDSQDEE-NNELVRTWTPENYKKPEQIAAATGAP 149 Query: 167 -KYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYT 225 K SH ++++ +DG++ E+G + G RGYFL+ VFL QALI Y L L S+GY+P+ Sbjct: 150 AKLSHHEVLLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLSSKGYVPLQA 209 Query: 226 PFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWL 285 P M KEVM + AQLSQFDEELYKVI + DEKYLIATSEQPI+A H EW Sbjct: 210 PVMMNKEVMAKTAQLSQFDEELYKVI---------DGEDEKYLIATSEQPISAYHAGEWF 260 Query: 286 R--PEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEE 343 E LP++YAG S+CFR+E GSHG+D GIFRVH FEKIEQFV + P KSWE F+ Sbjct: 261 ESPAEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQFVLTEPE--KSWEEFDR 318 Query: 344 MITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQA 403 MI +EEFYQSLG+PY +V IVSG LN+AA+KK DLEAWFP ++ELVSCSNCTDYQ+ Sbjct: 319 MIGCSEEFYQSLGLPYRVVGIVSGELNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDYQS 378 Query: 404 RRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPG 463 R L IR G ++ + ++VH LN+T+ AT RTIC ILENYQ E G+ +PE L++++ PG Sbjct: 379 RNLEIRCGIKQQNQQEKKYVHCLNSTLSATERTICCILENYQKEDGLVIPEVLRKYI-PG 437 Query: 464 LQELIPFVKPAPIEQEPSKKQK---KQHEGSKKKAAARD 499 E IP++K P KK K ++ S KKA ++ Sbjct: 438 EPEFIPYIKELPKNTTSVKKAKGKNPKNTTSVKKAKGKN 476 >6OTE-A nrPDB Length = 572 Score = 381 bits (979), Expect = e-106, Method: Compositional matrix adjust. Identities = 214/477 (44%), Positives = 299/477 (62%), Gaps = 39/477 (8%) Query: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 M +D++ RV+KGGD I E++ R+K +++LVK D +WR F+ + K N Sbjct: 119 MPIDINRIRVEKGGDYQKIAESEMARYKGLETLEELVKVDQKWREDMFKLEQSKKELNSI 178 Query: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 SK I + +KKK+P D + + + K Q+KK +I++ L+ + Sbjct: 179 SKEIAQ-IKKKDPKADCKDLQD----------------KSVQLKKNLPIIEKQALETEEV 221 Query: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRK------KYSHVDLV 174 R KL +IGN+L P VPISN ED DN V R WG+ K K H +++ Sbjct: 222 RDKL-------WHKIGNVLQPDVPISNTED-DNLVLRTWGEIPDIKVDGTPGKLHHNEIM 273 Query: 175 VMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVM 234 + ++ KGA +AG RGYFLK V + AL YA+ L +GY+ I P+FM++++M Sbjct: 274 SRLGFYDSVKGAELAGHRGYFLKDYGVIMSMALSHYAMGFLLKKGYLAIQPPYFMKRDLM 333 Query: 235 QEVAQLSQFDEELYKVIGKGSE-KSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIK 293 + A+L F+E LY + S+ + D NS +LIATSEQPIAA+H + L +DLPIK Sbjct: 334 GKAAELQDFEETLYHIPSDNSKGEVDSNSL---FLIATSEQPIAAMHHNVTLEDKDLPIK 390 Query: 294 YAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQ 353 YAG+STCFR+E G+HG+DT GIFR+HQFEK+EQF + P D S ++ EEMI+ +EEFYQ Sbjct: 391 YAGISTCFRKEAGAHGKDTWGIFRIHQFEKVEQFCVTLPED--SQKIHEEMISISEEFYQ 448 Query: 354 SLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQT 413 SL +PY +++IVSG+LN AASKK DLEAWFPG ++RELVSCSNCTDYQ+R L R G Sbjct: 449 SLELPYRVISIVSGALNDAASKKYDLEAWFPGYNSYRELVSCSNCTDYQSRALECRLGFR 508 Query: 414 KKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPF 470 K+ + + H LN T+CA RT+C I+ENYQT G+ +P+ L+ +M G+ E IPF Sbjct: 509 KEGEREKHYCHFLNGTLCAIQRTMCCIVENYQTPDGLRIPKVLQPYM-NGV-EFIPF 563 >2ZR2-A nrPDB Length = 455 Score = 302 bits (773), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 186/496 (37%), Positives = 278/496 (56%), Gaps = 73/496 (14%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKR--FKDPGLVDQLVKADSEWRRCRFRADNLNKLKNL 59 +LD+ L R +P L++ KR + VD+++K D+EWR + L +N Sbjct: 1 MLDIKLIR----ENPELVKNDLIKRGELEKVKWVDEILKLDTEWRTKLKEINRLRHERNK 56 Query: 60 CSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDA 119 + IG++ KK EPV D+L A + +++ I E L+ + Sbjct: 57 IAVEIGKRRKKGEPV-------------DELLAKS---------REIVKRIGE--LENEV 92 Query: 120 ERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYS---------- 169 E +K + + + L + N+ HPSVP+ DE+ DN R WG V K + Sbjct: 93 EELKKKIDYY--LWRLPNITHPSVPVGKDEN-DNVPIRFWGKARVWKGHLERFLEQSQGK 149 Query: 170 ------------HVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGS 217 HVDL+ ++ G + + A V+GSR Y+L +V L+ ALI++AL L Sbjct: 150 MEYEILEWKPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIE 209 Query: 218 RGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIA 277 +G+ P+ P+ +R+ V + F++ +YKV ++ YLI T+E P+A Sbjct: 210 KGFTPVIPPYMVRRFVEEGSTSFEDFEDVIYKV-----------EDEDLYLIPTAEHPLA 258 Query: 278 ALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKS 337 +H +E L +DLP+ Y G+S CFR+E G+ G+DT+GIFRVHQF K+EQFVYS P + S Sbjct: 259 GMHANEILDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEE--S 316 Query: 338 WEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSN 397 WE E++I AEE +Q L IPY +VNI +G L + A+KK D+EAW PG G FRE+VS SN Sbjct: 317 WEWHEKIIRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGKFREVVSASN 376 Query: 398 CTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKL 456 CTD+QARRL IR+ + +K +VH LN+T AT+R I AILEN+Q E G + +P+ L Sbjct: 377 CTDWQARRLNIRF--RDRTDEKPRYVHTLNSTAIATSRAIVAILENHQEEDGTVRIPKVL 434 Query: 457 KEFMPPGLQELIPFVK 472 ++ G +E++P K Sbjct: 435 WKYT--GFKEIVPVEK 448 >2DQ3-A nrPDB Length = 425 Score = 233 bits (595), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 161/466 (34%), Positives = 249/466 (53%), Gaps = 56/466 (12%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKD-PGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 ++D++L R P ++E R K+ LVD++++ D R R + L +N Sbjct: 1 MIDINLIR----EKPDYVKERLATRDKELVSLVDKVLELDKRRREIIKRLEALRSERNKL 56 Query: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 SK IG K+K++ G D + +N +V ++K E I + + E Sbjct: 57 SKEIG-KLKRE---GKDTTEIQN---------------RVKELK-------EEIDRLEEE 90 Query: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYS-----HVDLVV 175 K+E E L I NL HPSVP+ DE DN R WG+ +K+ H ++ Sbjct: 91 LRKVEEELKNTLLWIPNLPHPSVPVGEDEK-DNVEVRRWGEP---RKFDFEPKPHWEIGE 146 Query: 176 MVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQ 235 + + ++GA ++GSR + G LE+ALI + L +GY I P ++ E++ Sbjct: 147 RLGILDFKRGAKLSGSRFTVIAGWGARLERALINFMLDLHTKKGYKEICPPHLVKPEILI 206 Query: 236 EVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYA 295 QL +F+E+LYK D YLI T+E P+ L+R+E L+ E+LPI Sbjct: 207 GTGQLPKFEEDLYKC-----------ERDNLYLIPTAEVPLTNLYREEILKEENLPIYLT 255 Query: 296 GLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSL 355 + C+R+E G++G+D RGI R HQF+K+E + H + S++ E+++ AEE Q L Sbjct: 256 AYTPCYRREAGAYGKDIRGIIRQHQFDKVE--LVKIVHPDTSYDELEKLVKDAEEVLQLL 313 Query: 356 GIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKK 415 G+PY +V + +G L +A+K D+E WFP +RE+ SCSNC D+QARR+ R+ +K Sbjct: 314 GLPYRVVELCTGDLGFSAAKTYDIEVWFPSQNKYREISSCSNCEDFQARRMNTRFKDSK- 372 Query: 416 MMDKVEFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKLKEFM 460 K FVH LN + A RT+ AILENYQ E G + VPE L++++ Sbjct: 373 -TGKNRFVHTLNGSGLAVGRTLAAILENYQQEDGSVVVPEVLRDYV 417 >6H9X-A nrPDB Length = 430 Score = 212 bits (539), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 147/438 (33%), Positives = 217/438 (49%), Gaps = 51/438 (11%) Query: 33 VDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTA 92 VD+L + + + + +NL +N SK+IG+ + E Sbjct: 27 VDKLRALEERRKVLQVQTENLQAERNSRSKSIGQAKARGE-------------------- 66 Query: 93 DALANLKVSQIKKVRLLIDEAILKCDAERIKLE---AERFENLREIGNLLHPSVPISNDE 149 I+ +RL +++ + DA + +LE AE + I N+ H VP+ DE Sbjct: 67 ---------DIEPLRLEVNKLGEQLDAAKSELETLLAEIRDIALAIPNIPHDDVPVGRDE 117 Query: 150 DVDNKVERIWG-----DCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLE 204 + + +V R WG D VR HV L M G + + GSR +KG L L Sbjct: 118 NDNVEVSR-WGTPRQFDFEVR---DHVTLGEMHGGLDFAAAVKLTGSRFVVMKGQLARLH 173 Query: 205 QALIQYALRTLGSR-GYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSY 263 +AL Q+ L + GY Y P+ + ++ + QL +F +L+ E++D ++Y Sbjct: 174 RALAQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHT-RPLEEEADSSNY 232 Query: 264 DEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEK 323 LI T+E P+ L RDE + +DLPIK + CFR E GS+GRDTRG+ R+HQF+K Sbjct: 233 ---ALIPTAEVPLTNLVRDEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDK 289 Query: 324 IEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWF 383 +E P D S EEM AE+ Q LG+PY V + +G + +A K DLE W Sbjct: 290 VEMVQIVRPED--SMAALEEMTGHAEKVLQLLGLPYRKVALCTGDMGFSACKTYDLEVWV 347 Query: 384 PGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILEN 443 P +RE+ SCSN D+QARR++ R K K VH LN + A RT+ A++EN Sbjct: 348 PAQNTYREISSCSNVWDFQARRMQARC--RSKSDKKTRLVHTLNGSGLAVGRTLVALMEN 405 Query: 444 YQTEKG-ITVPEKLKEFM 460 YQ G I +PE L+ +M Sbjct: 406 YQQADGRIEIPEVLRPYM 423 >3ERR-A nrPDB Length = 536 Score = 195 bits (496), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 129/450 (28%), Positives = 228/450 (50%), Gaps = 43/450 (9%) Query: 36 LVKADSEWRRCR---FRADNLNKLKNLC----SKTIGEKMKKKEPVGDDESVPENVLSFD 88 L ++ ++W++ R R + + + N S I EKMKK + S +++ Sbjct: 101 LGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKN--YMSNPSYNYEIVNRA 158 Query: 89 DLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLL-------HP 141 L A + ++Q+ +L L+ + + KLE + +N +++ LL P Sbjct: 159 SLAAGPMVKWAIAQLNYADMLKRVEPLRNELQ--KLEDDAKDNQQKLEALLLQVPLPPWP 216 Query: 142 SVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMV--DGFEGEKGAVVAGSRGYFLKGV 199 P+ +E + +++R+ G + +D V ++ +G+ + + V+GSR Y LKG Sbjct: 217 GAPVGGEE-ANREIKRVGGPPEF--SFPPLDHVALMEKNGWWEPRISQVSGSRSYALKGD 273 Query: 200 LVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSD 259 L E AL+++A+ + RG++P+ P + R++ + ++++ + Sbjct: 274 LALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI--------- 324 Query: 260 DNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVH 319 + + YL T+E + ALH E L E LP++YAG + FR E GS G+D RG+ RVH Sbjct: 325 --AETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPAFRSEAGSFGKDVRGLMRVH 382 Query: 320 QFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDL 379 QF K+EQ+V + S F+E++ AEE + L +PY +V + +G + +++D+ Sbjct: 383 QFHKVEQYVLTEASLEASDRAFQELLENAEEILRLLELPYRLVEVATGDMGPGKWRQVDI 442 Query: 380 EAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICA 439 E + P G +RE SCS D+QARR +RY + +V + + LN T AT R + Sbjct: 443 EVYLPSEGRYRETHSCSALLDWQARRANLRYRDPE---GRVRYAYTLNNTALATPRILAM 499 Query: 440 ILENYQTEKG-ITVPEKL-----KEFMPPG 463 +LEN+Q + G + VP+ L KE + PG Sbjct: 500 LLENHQLQDGRVRVPQALIPYMGKEVLEPG 529 >1SER-A nrPDB Length = 421 Score = 189 bits (480), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 102/323 (31%), Positives = 175/323 (54%), Gaps = 20/323 (6%) Query: 141 PSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMV--DGFEGEKGAVVAGSRGYFLKG 198 P P+ +E + +++R+ G + +D V ++ +G+ + + V+GSR Y LKG Sbjct: 107 PGAPVGGEE-ANREIKRVGGPPEF--SFPPLDHVALMEKNGWWEPRISQVSGSRSYALKG 163 Query: 199 VLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKS 258 L E AL+++A+ + RG++P+ P + R++ + ++++ + Sbjct: 164 DLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI-------- 215 Query: 259 DDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRV 318 + + YL T+E + ALH E L E LP++YAG + FR E GS G+D RG+ RV Sbjct: 216 ---AETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPAFRSEAGSFGKDVRGLMRV 272 Query: 319 HQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLD 378 HQF K+EQ+V + S F+E++ AEE + L +PY +V + +G + +++D Sbjct: 273 HQFHKVEQYVLTEASLEASDRAFQELLENAEEILRLLELPYRLVEVATGDMGPGKWRQVD 332 Query: 379 LEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTIC 438 +E + P G +RE SCS D+QARR +RY + +V + + LN T AT R + Sbjct: 333 IEVYLPSEGRYRETHSCSALLDWQARRANLRYRDPE---GRVRYAYTLNNTALATPRILA 389 Query: 439 AILENYQTEKG-ITVPEKLKEFM 460 +LEN+Q + G + VP+ L +M Sbjct: 390 MLLENHQLQDGRVRVPQALIPYM 412 >1WLE-A nrPDB Length = 501 Score = 179 bits (454), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 103/342 (30%), Positives = 179/342 (52%), Gaps = 18/342 (5%) Query: 123 KLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGD--CTVRKKYSHVDLVVMVDGF 180 +LE + + + N HP VP+ ++ +V + GD + H+++ +D Sbjct: 141 QLEEQFYLRALRLPNQTHPDVPVGDESQA--RVLHVVGDKPAFSFQPRGHLEIAEKLDII 198 Query: 181 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL 240 ++ + V+G R Y+L+G L+ L+ + L L RG+ P+ P +R V + Sbjct: 199 RQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLNKLIHRGFTPMTVPDLLRGVVFEGCGMT 258 Query: 241 SQF-DEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLST 299 ++Y + D + +++ L T+E +A D + DLPI+ ST Sbjct: 259 PNAKPSQIYNI--------DPSRFEDLNLAGTAEVGLAGYFMDHSVAFRDLPIRMVCSST 310 Query: 300 CFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPY 359 C+R E + G++ G++RVH F K+E F + P +S E+ EE ++ E LG+ + Sbjct: 311 CYRAETDT-GKEPWGLYRVHHFTKVEMFGVTGPGLEQSSELLEEFLSLQMEILTELGLHF 369 Query: 360 HIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDK 419 ++++ + L A +K D+EAW PG G F E+ S SNCTD+Q+RRL I + QT+ + Sbjct: 370 RVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVTSASNCTDFQSRRLHIMF-QTEA--GE 426 Query: 420 VEFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKLKEFM 460 ++F H +NAT CA R + A+LE+YQ + G + VP L+ ++ Sbjct: 427 LQFAHTVNATGCAVPRLLIALLESYQQKDGSVLVPPALQPYL 468 >1NJ2-A nrPDB Length = 501 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 60/270 (22%), Positives = 109/270 (40%), Gaps = 28/270 (10%) Query: 194 YFLKGVLVFLEQALI-----QYALRTLGSRGYIPIYTPFFM-RKEVMQEVAQLSQFDEEL 247 Y +KG+ V++ + LR + R + + P + E+ +E + F++E+ Sbjct: 58 YPVKGMHVWMPHGFMIRKNTLKILRRILDRDHEEVLFPLLVPEDELAKEAIHVKGFEDEV 117 Query: 248 YKVIGKGSEKSDDNSYDEKYLIATSEQ---PIAALHRDEWLRPE-DLPIKYAGLSTCFRQ 303 Y V G K L TSE P+ AL W+R DLP+++ + FR Sbjct: 118 YWVTHGGLSKLQRKLA----LRPTSETVMYPMFAL----WVRSHTDLPMRFYQVVNTFRY 169 Query: 304 EVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVN 363 E + TR + RV + ++ +++ E E + +EF+ SLGIPY I Sbjct: 170 ET----KHTRPLIRVREITTFKEAHTIHATASEAEEQVERAVEIYKEFFNSLGIPYLITR 225 Query: 364 IVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFV 423 + + + P G ++ + N AR I++ + E+V Sbjct: 226 RPPWDKFPGSEYTVAFDTLMP-DGKTLQIGTVHNLGQTFARTFEIKFETPE---GDHEYV 281 Query: 424 HMLNATMCATTRTICAILENYQTEKGITVP 453 H + R I +++ + E G+ +P Sbjct: 282 H--QTCYGLSDRVIASVIAIHGDESGLCLP 309 >1NJ8-A nrPDB Length = 459 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 48/220 (21%), Positives = 89/220 (40%), Gaps = 16/220 (7%) Query: 235 QEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPE-DLPIK 293 +E + F++E+Y V G + D L TSE PI + + W++ DLPIK Sbjct: 73 KEAEHIKGFEDEVYWVTHGGKTQLDVKLA----LRPTSETPIYYMMK-LWVKVHTDLPIK 127 Query: 294 YAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQ 353 + FR E + TR + R+ + ++ + ++ +E I+ ++F+ Sbjct: 128 IYQIVNTFRYET----KHTRPLIRLREIMTFKEAHTAHSTKEEAENQVKEAISIYKKFFD 183 Query: 354 SLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQT 413 +LGIPY I A + + FP G ++ + N ++ I + Sbjct: 184 TLGIPYLISKRPEWDKFPGAEYTMAFDTIFP-DGRTMQIATVHNLGQNFSKTFEIIFETP 242 Query: 414 KKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVP 453 D + + R I +I+ + EKG+ +P Sbjct: 243 TGDKD-----YAYQTCYGISDRVIASIIAIHGDEKGLILP 277 >5UCM-A nrPDB Length = 579 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 51/242 (21%), Positives = 102/242 (42%), Gaps = 42/242 (17%) Query: 215 LGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIA-TSE 273 + + G + + P E+ QE + Q+ EL ++ + ++ ++ + T E Sbjct: 69 MNAAGALEVLMPAVQPAELWQESGRWEQYGPELLRL---------KDRHEREFCVGPTHE 119 Query: 274 QPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPH 333 + I L R+E + LPI + + T FR E+ R G+ R +F + + + Sbjct: 120 EVITDLARNELNSYKQLPINFYQIQTKFRDEI----RPRFGLMRGREFIMKDAYSFHLSQ 175 Query: 334 DNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELV 393 D+ + ++ M + + LG+ + V +GS+ + S + + A SG + + Sbjct: 176 DSLQ-QTYDGMYQAYSKIFSRLGLDFRPVQADNGSIGGSGSHEFHVLA---NSG--EDDI 229 Query: 394 SCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCAT----------TRTICAILEN 443 S+ +DY A ++K E V +A AT T+TI A+++ Sbjct: 230 VFSDSSDYAAN------------IEKAEAVPRESARGSATEDMRLVDTPNTKTIAALVDG 277 Query: 444 YQ 445 +Q Sbjct: 278 FQ 279 >3W3S-A nrPDB Length = 527 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 13/129 (10%) Query: 240 LSQFDEELYKVIGKGSEKS----DDNSYDEKYLIATSE-QPIAALHRDEWLRPEDLPIK- 293 F ELY V G+ +E++ + D Y++A ++ +P L RDE + PE LPIK Sbjct: 282 FDDFKRELY-VWGELNERTLGSLKEKLRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKL 340 Query: 294 YAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQ 353 Y +R E G+ +G+ RV++F++IE + P + ++ + E++ + + Sbjct: 341 YDCSGWTYRWEGGA----AKGLERVNEFQRIEHVWIAEPEE--AYRIRRELLEATKRVAE 394 Query: 354 SLGIPYHIV 362 L + + +V Sbjct: 395 ELELEWKVV 403 >5Z5E-A nrPDB Length = 534 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 39/211 (18%), Positives = 79/211 (37%), Gaps = 38/211 (18%) Query: 271 TSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYS 330 T++ P R+ L + LP+ A + FR E+ + + R+ +F + E ++ Sbjct: 208 TAQGPYVMFKREFILHRQKLPLGLAVVGKAFRNEISPR----QLLLRLREFTQAELQIFF 263 Query: 331 SPHDNK-----------------------------SWEMFEEMITTAEEFYQSLGIPYHI 361 P DN+ E + + ++FY+ LGIP Sbjct: 264 DPEDNEFDINEVKDVELNFLDKEGNYKRIKVKDLPFPEFYAYFVGKVKQFYERLGIPEER 323 Query: 362 VNIVSGSLNHAA---SKKLDLEAWFPGSGAFRELVSCSNCTDYQ-ARRLRIRYGQTKKMM 417 + S A +D+E FP G ++E+ TD+ + +++ Sbjct: 324 LRFRELSEKEKAFYNKYHVDIEINFPTYG-WKEVGGIHYRTDHDLSGHMKVSGKDLTVQK 382 Query: 418 DKVEFVHMLNATMCATTRTICAILENYQTEK 448 D +F+ + R + A+++ + TE+ Sbjct: 383 DNKKFIPHVLELSFGVDRNVLALIDLFLTEE 413 >5XIG-A nrPDB Length = 500 Score = 32.7 bits (73), Expect = 0.39, Method: Compositional matrix adjust. Identities = 46/241 (19%), Positives = 93/241 (38%), Gaps = 28/241 (11%) Query: 224 YTPFFM-RKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRD 282 Y P F+ R ++ +E + F E+ V G D+ EK I + + I Sbjct: 65 YFPMFVSRHKLEKEKDHVEGFSPEVAWVTHYG-----DSPLPEKIAIRPTSETIMYPAYA 119 Query: 283 EWLRPE-DLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPH-----DNK 336 +W+R DLP+K + R E + F + +F++ H + + Sbjct: 120 KWIRSHRDLPLKLNQWCSVVRWEFK----------QPTPFLRTREFLWQEGHTAHATEEE 169 Query: 337 SWEMFEEMITTAEEFYQ-SLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSC 395 +WE+ +++ +Y+ L +P G K +EA+ P +G + + Sbjct: 170 AWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGKKTTTVEAFIPENGRGIQAATS 229 Query: 396 SNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEK 455 A+ I + + VH + TTR++ ++ + +KG+ +P + Sbjct: 230 HLLGTNFAKMFEIEFEDEE---GHKRLVH--QTSWGCTTRSLGVMIMTHGDDKGLVIPPR 284 Query: 456 L 456 + Sbjct: 285 V 285 >1LPD-A nrPDB Length = 254 Score = 32.3 bits (72), Expect = 0.56, Method: Compositional matrix adjust. Identities = 29/81 (35%), Positives = 39/81 (48%), Gaps = 20/81 (24%) Query: 97 NLKVSQI----KKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD 152 NL ++ I KKVR++ DEA A ++ EA RF R I NL+ + P N D + Sbjct: 145 NLLITMIDGVNKKVRVVKDEARFLLIAIQMTAEAARF---RYIQNLVTKNFP--NKFDSE 199 Query: 153 NKV-----------ERIWGDC 162 NKV I+GDC Sbjct: 200 NKVIQFQVSWSKISTAIFGDC 220 >4NX9-A nrPDB Length = 293 Score = 31.6 bits (70), Expect = 0.81, Method: Compositional matrix adjust. Identities = 21/53 (39%), Positives = 30/53 (56%), Gaps = 9/53 (16%) Query: 93 DALANLKVSQIKKVR---LLIDEAILKCDAERIKLEA--ERFE----NLREIG 136 D +A + +S K + L+IDEAI + DA+R L A RF+ NL+ IG Sbjct: 235 DTVAKIDISTAKGAQSAVLVIDEAIKQIDAQRADLGAVQNRFDNTINNLKNIG 287 >1ATI-A nrPDB Length = 505 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 52/222 (23%), Positives = 85/222 (38%), Gaps = 40/222 (18%) Query: 295 AGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS 354 A + FR E+ IFRV +FE++E + P +++ W + + +++Q Sbjct: 213 AQIGKAFRNEITPRN----FIFRVREFEQMEIEYFVRPGEDEYWHRY--WVEERLKWWQE 266 Query: 355 LG------IPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDY------- 401 +G +PY S H A +D+ FP G+ EL + TD+ Sbjct: 267 MGLSRENLVPYQQPPESSA---HYAKATVDILYRFP-HGSL-ELEGIAQRTDFDLGSHTK 321 Query: 402 -------QARRLRIRYGQTKKMMDKVE----FVHMLNATMCATTRTICAILENYQTEKGI 450 AR LR + + E FV + R + A+L T + + Sbjct: 322 DQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREEL 381 Query: 451 TVPE-----KLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQ 487 E KLK + P +IP VK P E +K+ K + Sbjct: 382 PNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKAR 423 >1B76-A nrPDB Length = 442 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 52/222 (23%), Positives = 85/222 (38%), Gaps = 40/222 (18%) Query: 295 AGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS 354 A + FR E+ IFRV +FE++E + P +++ W + + +++Q Sbjct: 150 AQIGKAFRNEITPRN----FIFRVREFEQMEIEYFVRPGEDEYWHRY--WVEERLKWWQE 203 Query: 355 LG------IPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDY------- 401 +G +PY S H A +D+ FP G+ EL + TD+ Sbjct: 204 MGLSRENLVPYQQPPESSA---HYAKATVDILYRFP-HGSL-ELEGIAQRTDFDLGSHTK 258 Query: 402 -------QARRLRIRYGQTKKMMDKVE----FVHMLNATMCATTRTICAILENYQTEKGI 450 AR LR + + E FV + R + A+L T + + Sbjct: 259 DQEALGITARVLRNEHSTQRLAYRDPETGKWFVPYVIEPSAGVDRGVLALLAEAFTREEL 318 Query: 451 TVPE-----KLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQ 487 E KLK + P +IP VK P E +K+ K + Sbjct: 319 PNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKAR 360 >5EXX-A nrPDB Length = 343 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 78/188 (41%), Gaps = 29/188 (15%) Query: 54 NKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEA 113 NK +N+ + I K E + +D + E++ ++ +A L+ +++ + LL++E Sbjct: 139 NKTQNVDVRIIAATHKNLEKMIEDGTFREDLYYRLNVFPIEMAPLR-ERVEDIALLLNEL 197 Query: 114 ILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVER--------IWGDCTVR 165 I + + E K + RF N I +L P N ++ N VER + G + Sbjct: 198 ISRMEHE--KRGSIRF-NSAAIMSLCRHDWP-GNVRELANLVERLAIMHPYGVIGVGELP 253 Query: 166 KKYSHVD----------------LVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQ 209 KK+ HVD + G G + + G LK L LEQ LIQ Sbjct: 254 KKFRHVDDEDEQLASSLREELEERAAINAGLPGMDAPAMLPAEGLDLKDYLANLEQGLIQ 313 Query: 210 YALRTLGS 217 AL G Sbjct: 314 QALDDAGG 321 >4YYE-A nrPDB Length = 460 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 33/157 (21%), Positives = 67/157 (42%), Gaps = 15/157 (9%) Query: 190 GSRGYFLKGVLVFLEQALIQYA-LRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELY 248 GS + G +F LI++ L+ G+ + TP +K + ++ + ++++ Sbjct: 55 GSMFFLPNGAKIF--NKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMF 112 Query: 249 KVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRP-EDLPIKYAGLSTCFRQEVGS 307 KV EK E+Y + P L + R +LP++++ S R E Sbjct: 113 KVETTDEEK-------EEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLHRNEASG 165 Query: 308 HGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEM 344 G+ R+ +F + + ++ +P KS E+F + Sbjct: 166 A---LSGLTRLRKFHQDDGHIFCTPSQVKS-EIFNSL 198 >5E2F-A nrPDB Length = 270 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 36/168 (21%), Positives = 64/168 (38%), Gaps = 21/168 (12%) Query: 310 RDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSL 369 +DT G F +H +K + FVY+ N+ Q+ + +VN + G Sbjct: 47 KDTDGTFILHDLQKDQTFVYNRKRANQR---------------QTPQSTFKVVNALIGLQ 91 Query: 370 NHAASKKLDLEAWFPGSGAFRELVSCS--NCTDYQARRLRIRYGQTKKMMDKVEFVHMLN 427 A + D++ W G RE S + + R I Y Q E + Sbjct: 92 VKAVRDEYDVKRW---DGVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWL 148 Query: 428 ATMCATTRTICAILENYQTEKGITV-PEKLKEFMPPGLQELIPFVKPA 474 T+ I ++ + + +T+ P + + F+ +E +PF KP Sbjct: 149 HTLSYGNEDISGGIDQFWLQSSLTISPLEQETFLEKLAKEELPFDKPV 196 >5X2G-A nrPDB Length = 835 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 21/42 (50%), Gaps = 1/42 (2%) Query: 316 FRVHQFEKIEQFVYSSPHDNK-SWEMFEEMITTAEEFYQSLG 356 FR +KI++ S P K S + EE EEFYQS G Sbjct: 613 FRQKVLDKIDEIFVSKPERKKPSGALHEETFRKEEEFYQSYG 654 >5HXY-A nrPDB Length = 317 Score = 28.1 bits (61), Expect = 9.8, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 2/68 (2%) Query: 83 NVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPS 142 +VL++ + L NLK+S + +I+ K D +RI + AE E ++ +G+ L Sbjct: 162 SVLAYTGVRVGELCNLKISDVDLQESIINVRSGKGDKDRIVIMAE--ECVKALGSYLDLR 219 Query: 143 VPISNDED 150 + + D D Sbjct: 220 LSMDTDND 227 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4RQF-A nrPDB 733 0.0 6BLJ-A nrPDB 557 e-159 3LSS-A nrPDB 551 e-157 6GIR-A nrPDB 532 e-151 3QO8-A nrPDB 520 e-148 6OTE-A nrPDB 512 e-145 2ZR2-A nrPDB 461 e-130 2DQ3-A nrPDB 441 e-124 3ERR-A nrPDB 424 e-119 6H9X-A nrPDB 421 e-118 1WLE-A nrPDB 371 e-103 1SER-A nrPDB 371 e-103 1NJ2-A nrPDB 235 3e-62 1NJ8-A nrPDB 223 2e-58 5UCM-A nrPDB 167 8e-42 3W3S-A nrPDB 111 5e-25 Sequences not found previously or not previously below threshold: 3IAL-A nrPDB 136 2e-32 5XIG-A nrPDB 115 4e-26 5XIP-A nrPDB 113 2e-25 4K87-A nrPDB 111 7e-25 6MN8-A nrPDB 107 9e-24 4NCX-A nrPDB 106 3e-23 5F9Y-A nrPDB 105 4e-23 6NAB-A nrPDB 105 5e-23 5XIL-A nrPDB 102 2e-22 2J3M-A nrPDB 102 3e-22 1H4S-A nrPDB 102 5e-22 2I4O-A nrPDB 89 4e-18 2CIM-A nrPDB 84 1e-16 1QF6-A nrPDB 64 1e-10 4HWO-A nrPDB 63 4e-10 5Z5E-A nrPDB 58 1e-08 1NYR-A nrPDB 58 1e-08 4YYE-A nrPDB 57 2e-08 4P3N-A nrPDB 54 2e-07 1B76-A nrPDB 47 2e-05 1ATI-A nrPDB 46 3e-05 3A31-A nrPDB 46 4e-05 3VQX-A nrPDB 45 7e-05 2PME-A nrPDB 42 7e-04 6JP2-A nrPDB 41 0.001 1QE0-A nrPDB 36 0.057 4YCV-A nrPDB 35 0.096 2ZNJ-A nrPDB 33 0.38 1SDJ-A nrPDB 32 0.44 6AVE-A nrPDB 32 0.61 3IJ4-A nrPDB 32 0.61 5E6U-A nrPDB 31 1.2 5J6B-A nrPDB 31 1.3 2EQ6-A nrPDB 30 2.8 3QAU-A nrPDB 29 5.4 4YLS-A nrPDB 29 7.1 >4RQF-A nrPDB Length = 522 Score = 733 bits (1892), Expect = 0.0, Method: Composition-based stats. Identities = 513/514 (99%), Positives = 514/514 (100%) Query: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC Sbjct: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 Query: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE Sbjct: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 Query: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF 180 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF Sbjct: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF 180 Query: 181 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL 240 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL Sbjct: 181 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL 240 Query: 241 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC 300 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC Sbjct: 241 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC 300 Query: 301 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH 360 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH Sbjct: 301 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH 360 Query: 361 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV 420 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV Sbjct: 361 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV 420 Query: 421 EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP 480 EFVHMLNATMCATTRTICAILENYQT+KGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP Sbjct: 421 EFVHMLNATMCATTRTICAILENYQTKKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP 480 Query: 481 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA 514 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA Sbjct: 481 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA 514 >6BLJ-A nrPDB Length = 485 Score = 557 bits (1436), Expect = e-159, Method: Composition-based stats. Identities = 247/487 (50%), Positives = 335/487 (68%), Gaps = 30/487 (6%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 +LD++LFR KGG+P +IRE+Q +RF D LVD++++ D WR + +++ + S Sbjct: 9 MLDINLFREYKGGNPEIIRESQRRRFADVTLVDKVIELDEVWRATIGKLNHIKSFTGIIS 68 Query: 62 KTIGEKMKKKEPVGDDESVPENV-------LSFDDLTADALANLKVSQIKKVRLLIDEAI 114 K +G +MK K P+GDD +P+ V + + L +LA L +Q+KK+ I E Sbjct: 69 KEVGNRMKNKVPLGDDLELPKEVTDDVYALFTKEALEQGSLAKLNTNQLKKLSTYITEVH 128 Query: 115 LKCDAERIKLEAE-RFENLREIGNLLHPSVPISNDEDVDNKVERIWGDC-------TVRK 166 +K E +K + + R + L +IGN++H +V +S++ED +N + R+ G+ T K Sbjct: 129 IKNSEEEVKQKEKERDDVLLQIGNIVHETVVVSDNED-NNGIVRMVGNPRPKVDPETGYK 187 Query: 167 KYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTP 226 H+D++ + G E+G V G RGYFL G LV + AL YA+ L +GY+PIYTP Sbjct: 188 CLKHIDIMRKLGGLATEEGTQVGGGRGYFLLGDLVRMNLALQNYAIDFLAKKGYMPIYTP 247 Query: 227 FFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLR 286 FFM KE M++VAQLSQFDEELY V G+G ++KYLIATSEQPIAA H ++ Sbjct: 248 FFMTKEQMKKVAQLSQFDEELYTVTGEG---------EDKYLIATSEQPIAAFHLEKRFD 298 Query: 287 PEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIT 346 +LPIKY G+STCFR+EVG+HG+DT GIFRVHQFEKIEQFV +SP DNKSWEMF+EMI Sbjct: 299 ESELPIKYCGMSTCFRKEVGAHGKDTLGIFRVHQFEKIEQFVVTSPKDNKSWEMFDEMIG 358 Query: 347 TAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGS---GAFRELVSCSNCTDYQA 403 +E FYQSLGIPY +VNIVSG+LN+AA+KK DLEAWFPG+ +RELVSCSNCTDYQ Sbjct: 359 NSEAFYQSLGIPYRVVNIVSGALNNAAAKKFDLEAWFPGADEGNEYRELVSCSNCTDYQT 418 Query: 404 RRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPG 463 RRL ++YG++KK +VEF HMLN+T+ AT+RT+C I+ENYQT +G+ VPE L+ +M G Sbjct: 419 RRLEVKYGKSKKQGSEVEFCHMLNSTLTATSRTLCCIVENYQTPEGVNVPEVLQPYM--G 476 Query: 464 LQELIPF 470 + I F Sbjct: 477 GTKFIKF 483 >3LSS-A nrPDB Length = 484 Score = 551 bits (1420), Expect = e-157, Method: Composition-based stats. Identities = 242/490 (49%), Positives = 318/490 (64%), Gaps = 21/490 (4%) Query: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 MVLD+ LFR + G + +IRE+Q +RF DP +VD +++AD +WRR +F + KL N+C Sbjct: 6 MVLDIQLFRDETGAN--IIRESQRRRFADPDIVDAIIEADKKWRRTQFLTEASKKLINIC 63 Query: 61 SKTIGEKMKKKEPVGDDESVPENV---LSFDDLTADALANLKVSQIKKVRLLIDEAILKC 117 SK +G K K KE GD +P V L + + L V Q+K++ + + + Sbjct: 64 SKAVGAKKKAKEADGDTSEIPPQVKEAYENGTLKGEQVEQLCVLQLKQLSKDLSDQVAGL 123 Query: 118 DAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMV 177 E +LE ER + + +GN+LH SVPI+ DE+ N V R +G+ T R K +HV ++ + Sbjct: 124 AKEAQQLEEERDKLMLNVGNILHESVPIAQDEETGNTVVRTFGNTTKRAKLNHVSIMERL 183 Query: 178 DGFEGEKGAV-VAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQE 236 + K +AG R Y LKG LV L+ AL+ Y+L L RGY P Y PFF+ ++VM E Sbjct: 184 GMMDTSKAVTSMAGGRSYVLKGGLVQLQVALVSYSLDFLVKRGYTPFYPPFFLNRDVMGE 243 Query: 237 VAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAG 296 VAQLSQFDEELY+V G G D+KYLIATSE PIAA HR W P+KYAG Sbjct: 244 VAQLSQFDEELYQVSGDG---------DKKYLIATSEMPIAAYHRGRWFTELKEPLKYAG 294 Query: 297 LSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLG 356 +STCFR+E G+HGRDT GIFRVHQF+KIEQFV SP +SW E+MITT+EEF +SLG Sbjct: 295 MSTCFRKEAGAHGRDTLGIFRVHQFDKIEQFVVCSPRQEESWRHLEDMITTSEEFNKSLG 354 Query: 357 IPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYG---QT 413 +PY +VNI SG+LN+AA+KK DLEAWFP SGAFRELVSCSNCTDYQ++ + RYG + Sbjct: 355 LPYRVVNICSGALNNAAAKKYDLEAWFPASGAFRELVSCSNCTDYQSQSVNCRYGPNLRG 414 Query: 414 KKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKP 473 + E+ HMLN T+CA TRT+C I ENYQTE+G+ +P+ L+ +M E+I F Sbjct: 415 TAAQNVKEYCHMLNGTLCAITRTMCCICENYQTEEGVVIPDVLRPYMM--GIEMIRFENN 472 Query: 474 APIE-QEPSK 482 A E P K Sbjct: 473 AQAEGTTPDK 482 >6GIR-A nrPDB Length = 456 Score = 532 bits (1369), Expect = e-151, Method: Composition-based stats. Identities = 232/479 (48%), Positives = 312/479 (65%), Gaps = 43/479 (8%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 ++D++LFR +KG +P +IRE+Q +RF +VD+++K D EWR+ +F D+ K N + Sbjct: 1 MVDINLFREEKGNNPEIIRESQRRRFASVEIVDEIIKLDKEWRQRQFEVDSFRKEFNKLN 60 Query: 62 KTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAER 121 K + + KKE E + + + D TA +AE Sbjct: 61 KQVAQLKIKKEDAS--EIIQQTEKNKQDSTAK------------------------EAEV 94 Query: 122 IKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGD----CTVRKKYSHVDLVVMV 177 + A L ++GNL+H SVP+ DE +N V ++WG+ K +HVDLV ++ Sbjct: 95 REAYAALKAKLEQVGNLVHDSVPVDKDE-ANNLVIKLWGEKRFSTPGLKLKNHVDLVELL 153 Query: 178 DGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEV 237 + ++GA +AG+RG+FLKG + L QALI + L L RG+ + PFFMRK+VM + Sbjct: 154 GIADTKRGAEIAGARGFFLKGDGLMLNQALINFGLTFLKKRGFTGLQPPFFMRKDVMAKC 213 Query: 238 AQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGL 297 AQL+QFDEELYKV G+G D+KYLIAT+EQP+ A H DEW+ P +LP++YAG Sbjct: 214 AQLAQFDEELYKVTGEG---------DDKYLIATAEQPLCAYHIDEWIHPTELPLRYAGY 264 Query: 298 STCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGI 357 S+CFR+E GSHGRDT GIFRVHQFEKIEQF + P++N SWEM +EM+ +E+FYQ+L + Sbjct: 265 SSCFRKEAGSHGRDTLGIFRVHQFEKIEQFCITGPNENASWEMLDEMMKNSEDFYQALKL 324 Query: 358 PYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMM 417 PY IV+IVSG+LN AA+KK DLEAWFP S FRELVSCSNCTDYQARRL IRYGQ K Sbjct: 325 PYQIVSIVSGALNDAAAKKYDLEAWFPSSETFRELVSCSNCTDYQARRLEIRYGQKKSNE 384 Query: 418 DKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPI 476 ++VHMLN+T+ AT RTIC ILENYQ E G+ +PE L+ FM G + +PF K P+ Sbjct: 385 QTKQYVHMLNSTLTATERTICCILENYQREDGVDIPEVLQPFM--GGETFLPF-KAKPV 440 >3QO8-A nrPDB Length = 485 Score = 520 bits (1339), Expect = e-148, Method: Composition-based stats. Identities = 240/519 (46%), Positives = 317/519 (61%), Gaps = 64/519 (12%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 +LD++ F V+KGGDP +I+ +Q+KR LVD+++ EW + RF D NK N Sbjct: 1 MLDINAFLVEKGGDPEIIKASQKKRGDSVELVDEIIAEYKEWVKLRFDLDEHNKKLNSVQ 60 Query: 62 KTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAER 121 K IG++ K KE DL A+ K+S KK E Sbjct: 61 KEIGKRFKAKEDA-------------KDLIAE---KEKLSNEKK--------------EI 90 Query: 122 IKLEAERFENLR----EIGNLLHPSVPISNDEDVDNKVERIWGDCTVRK----------- 166 I+ EAE +NLR ++GN++H SV S DE+ +N++ R W +K Sbjct: 91 IEKEAEADKNLRSKINQVGNIVHESVVDSQDEE-NNELVRTWTPENYKKPEQIAAATGAP 149 Query: 167 -KYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYT 225 K SH ++++ +DG++ E+G + G RGYFL+ VFL QALI Y L L S+GY+P+ Sbjct: 150 AKLSHHEVLLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLSSKGYVPLQA 209 Query: 226 PFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWL 285 P M KEVM + AQLSQFDEELYKVI + DEKYLIATSEQPI+A H EW Sbjct: 210 PVMMNKEVMAKTAQLSQFDEELYKVI---------DGEDEKYLIATSEQPISAYHAGEWF 260 Query: 286 RP--EDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEE 343 E LP++YAG S+CFR+E GSHG+D GIFRVH FEKIEQFV + P KSWE F+ Sbjct: 261 ESPAEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQFVLTEPE--KSWEEFDR 318 Query: 344 MITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQA 403 MI +EEFYQSLG+PY +V IVSG LN+AA+KK DLEAWFP ++ELVSCSNCTDYQ+ Sbjct: 319 MIGCSEEFYQSLGLPYRVVGIVSGELNNAAAKKYDLEAWFPFQQEYKELVSCSNCTDYQS 378 Query: 404 RRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPG 463 R L IR G ++ + ++VH LN+T+ AT RTIC ILENYQ E G+ +PE L++++ PG Sbjct: 379 RNLEIRCGIKQQNQQEKKYVHCLNSTLSATERTICCILENYQKEDGLVIPEVLRKYI-PG 437 Query: 464 LQELIPFVKPAPIEQEPSKKQK---KQHEGSKKKAAARD 499 E IP++K P KK K ++ S KKA ++ Sbjct: 438 EPEFIPYIKELPKNTTSVKKAKGKNPKNTTSVKKAKGKN 476 >6OTE-A nrPDB Length = 572 Score = 512 bits (1318), Expect = e-145, Method: Composition-based stats. Identities = 211/479 (44%), Positives = 296/479 (61%), Gaps = 37/479 (7%) Query: 1 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 M +D++ RV+KGGD I E++ R+K +++LVK D +WR F+ + K N Sbjct: 119 MPIDINRIRVEKGGDYQKIAESEMARYKGLETLEELVKVDQKWREDMFKLEQSKKELNSI 178 Query: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 SK I + +KKK+P D + + + K Q+KK +I++ L+ + Sbjct: 179 SKEIAQ-IKKKDPKADCKDLQD----------------KSVQLKKNLPIIEKQALETEEV 221 Query: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRK------KYSHVDLV 174 R KL +IGN+L P VPISN ED DN V R WG+ K K H +++ Sbjct: 222 RDKL-------WHKIGNVLQPDVPISNTED-DNLVLRTWGEIPDIKVDGTPGKLHHNEIM 273 Query: 175 VMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVM 234 + ++ KGA +AG RGYFLK V + AL YA+ L +GY+ I P+FM++++M Sbjct: 274 SRLGFYDSVKGAELAGHRGYFLKDYGVIMSMALSHYAMGFLLKKGYLAIQPPYFMKRDLM 333 Query: 235 QEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKY 294 + A+L F+E LY + S+ D++ +LIATSEQPIAA+H + L +DLPIKY Sbjct: 334 GKAAELQDFEETLYHIPSDNSKGEVDSN--SLFLIATSEQPIAAMHHNVTLEDKDLPIKY 391 Query: 295 AGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS 354 AG+STCFR+E G+HG+DT GIFR+HQFEK+EQF + P D S ++ EEMI+ +EEFYQS Sbjct: 392 AGISTCFRKEAGAHGKDTWGIFRIHQFEKVEQFCVTLPED--SQKIHEEMISISEEFYQS 449 Query: 355 LGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTK 414 L +PY +++IVSG+LN AASKK DLEAWFPG ++RELVSCSNCTDYQ+R L R G K Sbjct: 450 LELPYRVISIVSGALNDAASKKYDLEAWFPGYNSYRELVSCSNCTDYQSRALECRLGFRK 509 Query: 415 KMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKP 473 + + + H LN T+CA RT+C I+ENYQT G+ +P+ L+ +M E IPF Sbjct: 510 EGEREKHYCHFLNGTLCAIQRTMCCIVENYQTPDGLRIPKVLQPYMN--GVEFIPFKNE 566 >2ZR2-A nrPDB Length = 455 Score = 461 bits (1185), Expect = e-130, Method: Composition-based stats. Identities = 186/496 (37%), Positives = 277/496 (55%), Gaps = 73/496 (14%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKR--FKDPGLVDQLVKADSEWRRCRFRADNLNKLKNL 59 +LD+ L R +P L++ KR + VD+++K D+EWR + L +N Sbjct: 1 MLDIKLIR----ENPELVKNDLIKRGELEKVKWVDEILKLDTEWRTKLKEINRLRHERNK 56 Query: 60 CSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDA 119 + IG++ KK EPV D+L A + +++ I E L+ + Sbjct: 57 IAVEIGKRRKKGEPV-------------DELLAKS---------REIVKRIGE--LENEV 92 Query: 120 ERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYS---------- 169 E +K + + + L + N+ HPSVP+ DE+ DN R WG V K + Sbjct: 93 EELKKKIDYY--LWRLPNITHPSVPVGKDEN-DNVPIRFWGKARVWKGHLERFLEQSQGK 149 Query: 170 ------------HVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGS 217 HVDL+ ++ G + + A V+GSR Y+L +V L+ ALI++AL L Sbjct: 150 MEYEILEWKPKLHVDLLEILGGADFARAAKVSGSRFYYLLNEIVILDLALIRFALDRLIE 209 Query: 218 RGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIA 277 +G+ P+ P+ +R+ V + F++ +YKV ++ YLI T+E P+A Sbjct: 210 KGFTPVIPPYMVRRFVEEGSTSFEDFEDVIYKV-----------EDEDLYLIPTAEHPLA 258 Query: 278 ALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKS 337 +H +E L +DLP+ Y G+S CFR+E G+ G+DT+GIFRVHQF K+EQFVYS P + S Sbjct: 259 GMHANEILDGKDLPLLYVGVSPCFRKEAGTAGKDTKGIFRVHQFHKVEQFVYSRPEE--S 316 Query: 338 WEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSN 397 WE E++I AEE +Q L IPY +VNI +G L + A+KK D+EAW PG G FRE+VS SN Sbjct: 317 WEWHEKIIRNAEELFQELEIPYRVVNICTGDLGYVAAKKYDIEAWMPGQGKFREVVSASN 376 Query: 398 CTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKL 456 CTD+QARRL IR+ +K +VH LN+T AT+R I AILEN+Q E G + +P+ L Sbjct: 377 CTDWQARRLNIRFRDRT--DEKPRYVHTLNSTAIATSRAIVAILENHQEEDGTVRIPKVL 434 Query: 457 KEFMPPGLQELIPFVK 472 ++ G +E++P K Sbjct: 435 WKYT--GFKEIVPVEK 448 >2DQ3-A nrPDB Length = 425 Score = 441 bits (1133), Expect = e-124, Method: Composition-based stats. Identities = 154/463 (33%), Positives = 240/463 (51%), Gaps = 50/463 (10%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKD-PGLVDQLVKADSEWRRCRFRADNLNKLKNLC 60 ++D++L R P ++E R K+ LVD++++ D R R + L +N Sbjct: 1 MIDINLIR----EKPDYVKERLATRDKELVSLVDKVLELDKRRREIIKRLEALRSERNKL 56 Query: 61 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE 120 SK IG+ ++ + ++I+ + E I + + E Sbjct: 57 SKEIGKLKREGKD--------------------------TTEIQNRVKELKEEIDRLEEE 90 Query: 121 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDC--TVRKKYSHVDLVVMVD 178 K+E E L I NL HPSVP+ DE DN R WG+ + H ++ + Sbjct: 91 LRKVEEELKNTLLWIPNLPHPSVPVGEDEK-DNVEVRRWGEPRKFDFEPKPHWEIGERLG 149 Query: 179 GFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVA 238 + ++GA ++GSR + G LE+ALI + L +GY I P ++ E++ Sbjct: 150 ILDFKRGAKLSGSRFTVIAGWGARLERALINFMLDLHTKKGYKEICPPHLVKPEILIGTG 209 Query: 239 QLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLS 298 QL +F+E+LYK D YLI T+E P+ L+R+E L+ E+LPI + Sbjct: 210 QLPKFEEDLYKC-----------ERDNLYLIPTAEVPLTNLYREEILKEENLPIYLTAYT 258 Query: 299 TCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIP 358 C+R+E G++G+D RGI R HQF+K+E P + S++ E+++ AEE Q LG+P Sbjct: 259 PCYRREAGAYGKDIRGIIRQHQFDKVELVKIVHP--DTSYDELEKLVKDAEEVLQLLGLP 316 Query: 359 YHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMD 418 Y +V + +G L +A+K D+E WFP +RE+ SCSNC D+QARR+ R+ +K Sbjct: 317 YRVVELCTGDLGFSAAKTYDIEVWFPSQNKYREISSCSNCEDFQARRMNTRFKDSK--TG 374 Query: 419 KVEFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKLKEFM 460 K FVH LN + A RT+ AILENYQ E G + VPE L++++ Sbjct: 375 KNRFVHTLNGSGLAVGRTLAAILENYQQEDGSVVVPEVLRDYV 417 >3ERR-A nrPDB Length = 536 Score = 424 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 126/441 (28%), Positives = 222/441 (50%), Gaps = 36/441 (8%) Query: 36 LVKADSEWRRCR---FRADNLNKLKNL----CSKTIGEKMKKKEPVGDDESVPENVLSFD 88 L ++ ++W++ R R + + + N S I EKMKK + S +++ Sbjct: 101 LGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKN--YMSNPSYNYEIVNRA 158 Query: 89 DLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNL-------LHP 141 L A + ++Q+ +L L+ + + KLE + +N +++ L P Sbjct: 159 SLAAGPMVKWAIAQLNYADMLKRVEPLRNELQ--KLEDDAKDNQQKLEALLLQVPLPPWP 216 Query: 142 SVPISNDEDVDNKVERIWGDCTV-RKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVL 200 P+ +E + +++R+ G HV L+ +G+ + + V+GSR Y LKG L Sbjct: 217 GAPVGGEE-ANREIKRVGGPPEFSFPPLDHVALMEK-NGWWEPRISQVSGSRSYALKGDL 274 Query: 201 VFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDD 260 E AL+++A+ + RG++P+ P + R++ + ++++ + Sbjct: 275 ALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHFPAYRDQVWAI---------- 324 Query: 261 NSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQ 320 + + YL T+E + ALH E L E LP++YAG + FR E GS G+D RG+ RVHQ Sbjct: 325 -AETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPAFRSEAGSFGKDVRGLMRVHQ 383 Query: 321 FEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLE 380 F K+EQ+V + S F+E++ AEE + L +PY +V + +G + +++D+E Sbjct: 384 FHKVEQYVLTEASLEASDRAFQELLENAEEILRLLELPYRLVEVATGDMGPGKWRQVDIE 443 Query: 381 AWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAI 440 + P G +RE SCS D+QARR +RY + +V + + LN T AT R + + Sbjct: 444 VYLPSEGRYRETHSCSALLDWQARRANLRYRDPE---GRVRYAYTLNNTALATPRILAML 500 Query: 441 LENYQTEKG-ITVPEKLKEFM 460 LEN+Q + G + VP+ L +M Sbjct: 501 LENHQLQDGRVRVPQALIPYM 521 >6H9X-A nrPDB Length = 430 Score = 421 bits (1082), Expect = e-118, Method: Composition-based stats. Identities = 151/466 (32%), Positives = 227/466 (48%), Gaps = 50/466 (10%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 +LD +L R + P + E +R VD+L + + + + +NL +N S Sbjct: 1 MLDPNLLRTE----PDAVAEKLARRGFKLD-VDKLRALEERRKVLQVQTENLQAERNSRS 55 Query: 62 KTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAER 121 K+IG+ + E I+ +RL +++ + DA + Sbjct: 56 KSIGQAKARGED-----------------------------IEPLRLEVNKLGEQLDAAK 86 Query: 122 IKLE---AERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDC--TVRKKYSHVDLVVM 176 +LE AE + I N+ H VP+ DE+ + +V R WG + HV L M Sbjct: 87 SELETLLAEIRDIALAIPNIPHDDVPVGRDENDNVEVSR-WGTPRQFDFEVRDHVTLGEM 145 Query: 177 VDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSR-GYIPIYTPFFMRKEVMQ 235 G + + GSR +KG L L +AL Q+ L + GY Y P+ + ++ + Sbjct: 146 HGGLDFAAAVKLTGSRFVVMKGQLARLHRALAQFMLDLHTEQHGYSENYVPYLVNQDTLY 205 Query: 236 EVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYA 295 QL +F +L+ E++D ++Y LI T+E P+ L RDE + +DLPIK Sbjct: 206 GTGQLPKFAGDLFH-TRPLEEEADSSNY---ALIPTAEVPLTNLVRDEIIDEDDLPIKMT 261 Query: 296 GLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSL 355 + CFR E GS+GRDTRG+ R+HQF+K+E P D S EEM AE+ Q L Sbjct: 262 AHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPED--SMAALEEMTGHAEKVLQLL 319 Query: 356 GIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKK 415 G+PY V + +G + +A K DLE W P +RE+ SCSN D+QARR++ R K Sbjct: 320 GLPYRKVALCTGDMGFSACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARC--RSK 377 Query: 416 MMDKVEFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKLKEFM 460 K VH LN + A RT+ A++ENYQ G I +PE L+ +M Sbjct: 378 SDKKTRLVHTLNGSGLAVGRTLVALMENYQQADGRIEIPEVLRPYM 423 >1WLE-A nrPDB Length = 501 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 111/457 (24%), Positives = 210/457 (45%), Gaps = 40/457 (8%) Query: 36 LVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADAL 95 ++ E R+ R + +L + K ++ + + ++ + Sbjct: 72 IISTWQELRQLREQIRSLEEEKEAVTEAVRALVVNQDNSQVQQDPQYQ------------ 119 Query: 96 ANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKV 155 ++ I + + + +LE + + + N HP VP+ ++ +V Sbjct: 120 ------SLRARGREIRKQLTLLYPKEAQLEEQFYLRALRLPNQTHPDVPVGDESQA--RV 171 Query: 156 ERIWG--DCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALR 213 + G + H+++ +D ++ + V+G R Y+L+G L+ L+ + L Sbjct: 172 LHVVGDKPAFSFQPRGHLEIAEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNFTLN 231 Query: 214 TLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLIATS 272 L RG+ P+ P +R V + ++Y + D + +++ L T+ Sbjct: 232 KLIHRGFTPMTVPDLLRGVVFEGCGMTPNAKPSQIYNI--------DPSRFEDLNLAGTA 283 Query: 273 EQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSP 332 E +A D + DLPI+ STC+R E + G++ G++RVH F K+E F + P Sbjct: 284 EVGLAGYFMDHSVAFRDLPIRMVCSSTCYRAETDT-GKEPWGLYRVHHFTKVEMFGVTGP 342 Query: 333 HDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFREL 392 +S E+ EE ++ E LG+ + ++++ + L A +K D+EAW PG G F E+ Sbjct: 343 GLEQSSELLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEV 402 Query: 393 VSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG-IT 451 S SNCTD+Q+RRL I + +++F H +NAT CA R + A+LE+YQ + G + Sbjct: 403 TSASNCTDFQSRRLHIMFQT---EAGELQFAHTVNATGCAVPRLLIALLESYQQKDGSVL 459 Query: 452 VPEKLKEFMPPGLQELIPFVKPAPIEQ-EPSKKQKKQ 487 VP L+ ++ + I P++ P++ QK + Sbjct: 460 VPPALQPYL---GTDRITTPTHVPLQYIGPNQPQKPR 493 >1SER-A nrPDB Length = 421 Score = 371 bits (951), Expect = e-103, Method: Composition-based stats. Identities = 122/461 (26%), Positives = 212/461 (45%), Gaps = 51/461 (11%) Query: 2 VLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCS 61 ++DL R + P + ++ L L+ D E + + R + +N + Sbjct: 1 MVDLKRLRQE----PEVFHRAIREKGVALDLE-ALLALDREVQELKKRLQEVQTERNQVA 55 Query: 62 KTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAER 121 K + P + L A A + E + + Sbjct: 56 KRV-------------PKAPPE--EKEALIARGKA-------------LGEEAKRLEEAL 87 Query: 122 IKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTV-RKKYSHVDLVVMVDGF 180 + EA L ++ P P+ +E + +++R+ G HV L+ +G+ Sbjct: 88 REKEARLEALLLQVPLPPWPGAPVGGEE-ANREIKRVGGPPEFSFPPLDHVALMEK-NGW 145 Query: 181 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL 240 + + V+GSR Y LKG L E AL+++A+ + RG++P+ P + R++ Sbjct: 146 WEPRISQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFLGTGHF 205 Query: 241 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC 300 + ++++ + + + YL T+E + ALH E L E LP++YAG + Sbjct: 206 PAYRDQVWAI-----------AETDLYLTGTAEVVLNALHSGEILPYEALPLRYAGYAPA 254 Query: 301 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH 360 FR E GS G+D RG+ RVHQF K+EQ+V + S F+E++ AEE + L +PY Sbjct: 255 FRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLENAEEILRLLELPYR 314 Query: 361 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV 420 +V + +G + +++D+E + P G +RE SCS D+QARR +RY + +V Sbjct: 315 LVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCSALLDWQARRANLRYRDPE---GRV 371 Query: 421 EFVHMLNATMCATTRTICAILENYQTEKG-ITVPEKLKEFM 460 + + LN T AT R + +LEN+Q + G + VP+ L +M Sbjct: 372 RYAYTLNNTALATPRILAMLLENHQLQDGRVRVPQALIPYM 412 >1NJ2-A nrPDB Length = 501 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 66/318 (20%), Positives = 124/318 (38%), Gaps = 27/318 (8%) Query: 194 YFLKGVLVFLEQALI-----QYALRTLGSRGYIPIYTPFFMR-KEVMQEVAQLSQFDEEL 247 Y +KG+ V++ + LR + R + + P + E+ +E + F++E+ Sbjct: 58 YPVKGMHVWMPHGFMIRKNTLKILRRILDRDHEEVLFPLLVPEDELAKEAIHVKGFEDEV 117 Query: 248 YKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGS 307 Y V G K L TSE + + DLP+++ + FR E Sbjct: 118 YWVTHGGLSKLQRKLA----LRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYET-- 171 Query: 308 HGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSG 367 + TR + RV + ++ +++ E E + +EF+ SLGIPY I Sbjct: 172 --KHTRPLIRVREITTFKEAHTIHATASEAEEQVERAVEIYKEFFNSLGIPYLITRRPPW 229 Query: 368 SLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLN 427 + + + P G ++ + N AR I++ + E+VH Sbjct: 230 DKFPGSEYTVAFDTLMP-DGKTLQIGTVHNLGQTFARTFEIKFETPE---GDHEYVH--Q 283 Query: 428 ATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQ 487 + R I +++ + E G+ +P + + I F K A E ++ + Sbjct: 284 TCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVP--IIFKKAAEEVMEACRELR-- 339 Query: 488 HEGSKKKAAARDVTLENR 505 S+ +AA V L++R Sbjct: 340 ---SRLEAAGFRVHLDDR 354 >1NJ8-A nrPDB Length = 459 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 57/295 (19%), Positives = 113/295 (38%), Gaps = 33/295 (11%) Query: 172 DLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQAL------IQYALRTLGSRGYIPIYT 225 D++ + ++ Y +KG V+L + L G+ Sbjct: 13 DILEKAEIYDVR----------YPIKGCGVYLPYGFKIRRYTFEIIRNLLDESGHDEALF 62 Query: 226 PFFMRKEVM-QEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEW 284 P + ++++ +E + F++E+Y V G + D L TSE PI + + W Sbjct: 63 PMLIPEDLLAKEAEHIKGFEDEVYWVTHGGKTQLDVKLA----LRPTSETPIYYMMK-LW 117 Query: 285 LRPE-DLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEE 343 ++ DLPIK + FR E + TR + R+ + ++ + ++ +E Sbjct: 118 VKVHTDLPIKIYQIVNTFRYET----KHTRPLIRLREIMTFKEAHTAHSTKEEAENQVKE 173 Query: 344 MITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQA 403 I+ ++F+ +LGIPY I A + + FP G ++ + N + Sbjct: 174 AISIYKKFFDTLGIPYLISKRPEWDKFPGAEYTMAFDTIFP-DGRTMQIATVHNLGQNFS 232 Query: 404 RRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKE 458 + I + D + + R I +I+ + EKG+ +P + Sbjct: 233 KTFEIIFETPTGDKD-----YAYQTCYGISDRVIASIIAIHGDEKGLILPPIVAP 282 >5UCM-A nrPDB Length = 579 Score = 167 bits (423), Expect = 8e-42, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 114/286 (39%), Gaps = 52/286 (18%) Query: 198 GVLVFLEQAL------IQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVI 251 G+ +L L + + G + + P E+ QE + Q+ EL ++ Sbjct: 46 GLYTWLPMGLRVLRKVETIVREEMNAAGALEVLMPAVQPAELWQESGRWEQYGPELLRL- 104 Query: 252 GKGSEKSDDNSYDEKYLI-ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGR 310 + ++ ++ + T E+ I L R+E + LPI + + T FR E+ R Sbjct: 105 --------KDRHEREFCVGPTHEEVITDLARNELNSYKQLPINFYQIQTKFRDEI----R 152 Query: 311 DTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLN 370 G+ R +F + + + D+ + ++ M + + LG+ + V +GS+ Sbjct: 153 PRFGLMRGREFIMKDAYSFHLSQDSLQ-QTYDGMYQAYSKIFSRLGLDFRPVQADNGSIG 211 Query: 371 HAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATM 430 + S + + A + + + S+ +DY A ++K E V +A Sbjct: 212 GSGSHEFHVLA-----NSGEDDIVFSDSSDYAAN------------IEKAEAVPRESARG 254 Query: 431 CAT----------TRTICAILENYQTEKGITVPEKLKEFMPPGLQE 466 AT T+TI A+++ +Q + + +K + G +E Sbjct: 255 SATEDMRLVDTPNTKTIAALVDGFQLP----IEKTIKTLVVHGAEE 296 >3IAL-A nrPDB Length = 518 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 93/300 (31%), Gaps = 27/300 (9%) Query: 192 RGYFLKG------VLVFLEQALIQYALRTLGSRGYIPIYTPFFMRK-EVMQEVAQLSQFD 244 R Y +KG F+E A+++ G I P + + + +E + F+ Sbjct: 40 RRYPVKGCVVFRPYGFFMENAIMRLCEEEYAKVGISQILFPTVIPESFLKKESDHIKGFE 99 Query: 245 EELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQE 304 E + V G + + L TSE I ++ +DLP+K T FR E Sbjct: 100 AECFWVEKGGLQP----LEERLALRPTSETAIYSMFSKWVRSYKDLPLKIHQTCTIFRHE 155 Query: 305 VGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFY-QSLGIPYHIVN 363 ++T+ + RV + + + + + + L + Sbjct: 156 T----KNTKPLIRVREIH-WNEAHCCHATAEDAVSQLSDYWKVIDTIFSDELCFKGQKLR 210 Query: 364 IVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFV 423 V A + P G + N + I Y E V Sbjct: 211 RVCWDRFPGADYSEVSDVVMPC-GRVLQTAGIHNLGQRFSSTFDILYANKA-----NESV 264 Query: 424 HMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKK 483 H +TR + L + G+ +P + P +IP QE ++ Sbjct: 265 HPYLTCAGISTRVLACALSIHGDSGGLVLP----PLIAPIHVVIIPIGCGKKNNQESDQQ 320 >5XIG-A nrPDB Length = 500 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 97/263 (36%), Gaps = 16/263 (6%) Query: 194 YFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFM-RKEVMQEVAQLSQFDEELYKVIG 252 Y ++ + + + ++ + G Y P F+ R ++ +E + F E+ V Sbjct: 35 YIMRPWAFHIWEKVQRFFDDEIKKMGVENSYFPMFVSRHKLEKEKDHVEGFSPEVAWVTH 94 Query: 253 KGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDT 312 G D ++ + TSE + + DLP+K + R E + Sbjct: 95 YG----DSPLPEKIAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWE----FKQP 146 Query: 313 RGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS-LGIPYHIVNIVSGSLNH 371 R +F ++ + + ++WE+ +++ +Y+ L +P G Sbjct: 147 TPFLRTREFL-WQEGHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFA 205 Query: 372 AASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMC 431 K +EA+ P +G + + A+ I + + VH + Sbjct: 206 GGKKTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEE---GHKRLVH--QTSWG 260 Query: 432 ATTRTICAILENYQTEKGITVPE 454 TTR++ ++ + +KG+ +P Sbjct: 261 CTTRSLGVMIMTHGDDKGLVIPP 283 >5XIP-A nrPDB Length = 498 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 42/263 (15%), Positives = 96/263 (36%), Gaps = 16/263 (6%) Query: 194 YFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFM-RKEVMQEVAQLSQFDEELYKVIG 252 Y ++ + +A+ ++ + G Y P F+ + ++ +E + F E+ V Sbjct: 36 YIIRPWAYRIWEAVQKFFDDGIKRLGVENCYFPMFVSQAKLEKEKDHVEGFKPEVAWVTH 95 Query: 253 KGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDT 312 G D ++ + TSE + + DLP+K + R E + Sbjct: 96 YG----DSELPEKVAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWNNVVRWE----FKQP 147 Query: 313 RGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS-LGIPYHIVNIVSGSLNH 371 R +F ++ + + +++ + E++ ++Y+ L +P Sbjct: 148 TPFLRTREFL-WQEGHTAHATEEEAYTLVLEILELYRQWYEDYLAVPVIKGEKSENEKFA 206 Query: 372 AASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMC 431 K +E P +G + + +R I + K + VH + Sbjct: 207 GGKKTTTIEGIIPDTGRGIQAATSHLLGQNFSRMFSIEFEDEK---GAKQLVH--QTSWG 261 Query: 432 ATTRTICAILENYQTEKGITVPE 454 TTR++ ++ + +KG+ +P Sbjct: 262 CTTRSLGVMIMTHGDDKGLVLPP 284 >3W3S-A nrPDB Length = 527 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 45/220 (20%), Positives = 87/220 (39%), Gaps = 45/220 (20%) Query: 207 LIQYALRTLGSR-GYIPIYTPFFMRKEVM--------------------QEVAQLSQFDE 245 L + L + + G+ P P + E M ++ F Sbjct: 228 LRDFLLERVTRKLGFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKR 287 Query: 246 ELYKVIGKGSEKS----DDNSYDEKYLIATSE-QPIAALHRDEWLRPEDLPIK-YAGLST 299 ELY V G+ +E++ + D Y++A ++ +P L RDE + PE LPIK Y Sbjct: 288 ELY-VWGELNERTLGSLKEKLRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKLYDCSGW 346 Query: 300 CFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPY 359 +R E G+ +G+ RV++F++IE + P + ++ + E++ + + L + + Sbjct: 347 TYRWEGGA----AKGLERVNEFQRIEHVWIAEPEE--AYRIRRELLEATKRVAEELELEW 400 Query: 360 HIVN-----------IVSGSLNHAASKKLDLEAWFPGSGA 388 +V + + + E + P G Sbjct: 401 KVVVSDDPFYLEGRLLEDRDIELPDVPSYEFEVYLPFKGE 440 >4K87-A nrPDB Length = 535 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 91/263 (34%), Gaps = 14/263 (5%) Query: 194 YFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVM-QEVAQLSQFDEELYKVIG 252 Y L+ + +A+ + + G Y P F+ + + +E ++ F E+ V Sbjct: 70 YILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAWVTR 129 Query: 253 KGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDT 312 G + + + TSE + + DLPIK R E + Sbjct: 130 SGKTE----LAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWE----FKHP 181 Query: 313 RGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS-LGIPYHIVNIVSGSLNH 371 + R +F ++ + ++ E +++ + Y+ L IP Sbjct: 182 QPFLRTREFL-WQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFA 240 Query: 372 AASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMC 431 +EA+ SG + + + ++ I + K + + +F + + Sbjct: 241 GGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPK-IPGEKQFAY--QNSWG 297 Query: 432 ATTRTICAILENYQTEKGITVPE 454 TTRTI + + G+ +P Sbjct: 298 LTTRTIGVMTMVHGDNMGLVLPP 320 >6MN8-A nrPDB Length = 505 Score = 107 bits (268), Expect = 9e-24, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 79/242 (32%), Gaps = 15/242 (6%) Query: 215 LGSRGYIPIYTPFFMRKEVM-QEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSE 273 + G Y P F+ + + +E +S F E+ + G + + + TSE Sbjct: 61 IKKLGVKNCYFPLFVSQSALEKEKTHISDFAPEVAWITRAG----QSDLAEAIAIRPTSE 116 Query: 274 QPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPH 333 + + DLPIK R E + R +F E Sbjct: 117 TVMYPSYAKWVQSHRDLPIKLNQWCNVVRWE----FKHPTPFLRTREFLWQEGHTAFQSK 172 Query: 334 DNKSWEMFEEMITTAEEFY-QSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFREL 392 D E+F +++ + Y L IP +EA+ P +G + Sbjct: 173 DEAEDEVF-KILDLYAQIYIDLLAIPVIKGRKTEKENFAGGDFTATVEAYVPVNGRGIQG 231 Query: 393 VSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITV 452 + + ++ I + ++ + +TRTI A++ + G+ + Sbjct: 232 ATSHHLGQNFSKMFNISFEDPNGGGK----IYAWQNSWGISTRTIGALVMIHGDNCGLVL 287 Query: 453 PE 454 P Sbjct: 288 PP 289 >4NCX-A nrPDB Length = 506 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 100/257 (38%), Gaps = 19/257 (7%) Query: 205 QALIQYALRTLGSRGYIPIYTPFFMRK-EVMQEVAQLSQFDEELYKVIGKGSEKSDDNSY 263 QA ++ L Y P F+ K ++ +E + F E+ V G D N Sbjct: 59 QAFFNKEIKKLN---VENSYFPLFVTKNKLEKEKNHIEGFSPEVAWVTKYG----DSNLP 111 Query: 264 DEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEK 323 +E + TSE + ++ DLP+K +T R E + R +F Sbjct: 112 EEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWE----FKQPTPFIRTREFL- 166 Query: 324 IEQFVYSSPHDNKSWEMFEEMITTAEEFYQS-LGIPYHIVNIVSGSLNHAASKKLDLEAW 382 ++ + ++ ++ ++ +++ +Y+ L +P G A+ EA+ Sbjct: 167 WQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKFGGANFTSTAEAF 226 Query: 383 FPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILE 442 +G + + A+ +I + + ++VH + TTR+I ++ Sbjct: 227 ISENGRAIQAATSHYLGTNFAKMFKIEFED---ENEVKQYVH--QTSWGCTTRSIGIMIM 281 Query: 443 NYQTEKGITVPEKLKEF 459 + +KG+ +P + ++ Sbjct: 282 THGDDKGLVLPPNVSKY 298 >5F9Y-A nrPDB Length = 511 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 52/314 (16%), Positives = 105/314 (33%), Gaps = 22/314 (7%) Query: 194 YFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFM-RKEVMQEVAQLSQFDEELYKVIG 252 Y L+ F+ + + + + Y P F+ +K++ E + F E+ V Sbjct: 49 YILRPWSYFIWETIQSVFDQKIKQHDVQNAYFPIFVTQKKLETEKDHVEGFSPEVAWVTK 108 Query: 253 KGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDT 312 G + + + TSE + DLP+K ++ R E + Sbjct: 109 SG----KSDLAEPIAIRPTSETIMYPYFAKWIRSHRDLPLKINQWTSIVRWE----FKHP 160 Query: 313 RGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQ-SLGIPYHIVNIVSGSLNH 371 R +F ++ + ++ EM + ++ Y+ L P Sbjct: 161 TPFIRTREFL-WQEGHTAHSTRKEALEMVDIILNEYASIYEDLLATPVVKGTKSENEKFP 219 Query: 372 AASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMC 431 +E + P G + + ++ + + K E+ H + Sbjct: 220 GGDITKSIEGFIPEIGRAVQAATSHLLGQNFSKMFGVEFEDEK---GNKEYAH--QTSWG 274 Query: 432 ATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGS 491 TTR I ++ + KG+ +P K+ + + + E KK + E Sbjct: 275 LTTRAIGVMIMTHGDNKGLVLPPKVAPVQVIIIPIIF-----KTVITEEQKKICNEVECI 329 Query: 492 KKKAAARDVTLENR 505 KKA R V +++R Sbjct: 330 LKKAGVR-VKIDDR 342 >6NAB-A nrPDB Length = 513 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 46/295 (15%), Positives = 106/295 (35%), Gaps = 22/295 (7%) Query: 215 LGSRGYIPIYTPFFMRKEVMQ-EVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSE 273 + G + P F+ K ++ E + F E+ V G+ + + L TSE Sbjct: 66 IKKLGVQNVMFPLFVTKRALETEKDHVEGFSPEVAWVTKSGNS----DLQEPIALRPTSE 121 Query: 274 QPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPH 333 + + DLP+K + R E + R +F ++ + Sbjct: 122 TIMYPSYAKWIQSHRDLPLKLNQWTNVVRWE----FKHAVPFIRSREFY-WQEGHSAFKS 176 Query: 334 DNKSWEMFEEMITTAEEFYQS-LGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFREL 392 ++ E ++ + Y+ L +P A +E + +G + Sbjct: 177 KEEADEEVFTILELYKRVYEELLAVPVIKGTKTENEKFAGADYTTTVETFIATNGRAVQG 236 Query: 393 VSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITV 452 + + ++ +I++ + + +F + + +TRT+ ++ + +KG+ + Sbjct: 237 GTSHHLGQNFSKMFKIQF---EAENKETQFAY--QNSWGLSTRTLGVMIMVHGDDKGMVL 291 Query: 453 PEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQ 507 P + +IP + +K K+ + +K A V L++RL+ Sbjct: 292 P----PRVAFCQVVVIPLIFKDKDNATLVEKTKEIYNELEK--AGIRVKLDDRLE 340 >5XIL-A nrPDB Length = 512 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 38/263 (14%), Positives = 83/263 (31%), Gaps = 14/263 (5%) Query: 194 YFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQ-EVAQLSQFDEELYKVIG 252 Y ++ ++ + + ++ + G Y P F+ + ++ E + F E+ V Sbjct: 36 YIIRPWAYYVWKCVQRFLGGKIEKLGVEDCYFPMFVSRSCLEREKDHIEGFAPEVAWVTR 95 Query: 253 KGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDT 312 G D + TSE + + DLP++ + R E Sbjct: 96 AG----DTELEQPVAVRPTSETVMYPYYAKWIRSHRDLPVRLNMWNNVIRWEFS----HP 147 Query: 313 RGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFY-QSLGIPYHIVNIVSGSLNH 371 R +F E + + + E+ E++ Y Q L +P Sbjct: 148 TPFIRTREFLWQEGHCAWAKAEECAKEVL-EILECYASVYEQLLAVPVVRGRKTEKEKFA 206 Query: 372 AASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMC 431 +E + G + + N + IR+ + + + Sbjct: 207 GGDYTTTVETFIEAVGRGCQGATSHNLGQNFGKMFDIRFQDPENNEQTLI---PWQNSWG 263 Query: 432 ATTRTICAILENYQTEKGITVPE 454 +TR I ++ + +G+ +P Sbjct: 264 LSTRVIGVMIMVHGDNRGMVMPP 286 >2J3M-A nrPDB Length = 572 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 71/189 (37%), Gaps = 24/189 (12%) Query: 219 GYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLI-ATSEQPIA 277 + + P + E+ +E + + LY++ + D Y++ T E+ Sbjct: 65 DAVEMLMPALLPAELWKESGRYETYGPNLYRL---------KDRNDRDYILGPTHEETFT 115 Query: 278 ALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYS--SPHDN 335 L RDE + LP+ + T +R E R G+ R +F + + + + Sbjct: 116 ELIRDEINSYKRLPLNLYQIQTKYRDE----KRSRSGLLRGREFIMKDGYSFHADEASLD 171 Query: 336 KSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSC 395 +S+ +E+ ++ G+ + + G++ SK+ S + + Sbjct: 172 QSYRDYEK---AYSRIFERCGLEFRAIIGDGGAMGGKDSKEF-----MAISEIGEDTICY 223 Query: 396 SNCTDYQAR 404 S +DY A Sbjct: 224 STESDYAAN 232 >1H4S-A nrPDB Length = 477 Score = 102 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 50/276 (18%), Positives = 94/276 (34%), Gaps = 32/276 (11%) Query: 195 FLKGVLVFLEQAL-----IQYALRTLGSR-GYIPIYTPFFMR-KEVMQEVAQLSQFDEEL 247 ++G +V IQ L + G+ Y P F+ + +E + F EL Sbjct: 32 PVRGTIVVRPYGYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSFLRKEAEHVEGFSPEL 91 Query: 248 YKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGS 307 V G E+ + + TSE I + DLP R E+ Sbjct: 92 AVVTHAGGEE----LEEPLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQWGNVVRWEM-- 145 Query: 308 HGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSG 367 TR R +F ++ + ++ E M++ + Y + ++ G Sbjct: 146 ---RTRPFLRTSEFL-WQEGHTAHATREEAEEEVRRMLSIYARLARE----YAAIPVIEG 197 Query: 368 -----SLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEF 422 A +EA G + + + AR I++ +V++ Sbjct: 198 LKTEKEKFAGAVYTTTIEALM-KDGKALQAGTSHYLGENFARAFDIKFQDRDL---QVKY 253 Query: 423 VHMLNATMCATTRTICAILENYQTEKGITVPEKLKE 458 VH + + R I AI+ + ++G+ +P +L Sbjct: 254 VHT--TSWGLSWRFIGAIIMTHGDDRGLVLPPRLAP 287 >2I4O-A nrPDB Length = 458 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 35/225 (15%), Positives = 77/225 (34%), Gaps = 27/225 (12%) Query: 181 EGEKGAVVAGSRGYFLKGVL--------VFLEQA------LIQYALRTLGSRGYIPIYTP 226 E K A + R G+L +L + Q G I + P Sbjct: 33 ENPKEAEIVSHRLMLRAGMLRQEAAGIYAWLPLGHRVLKKIEQIVREEQNRAGAIELLMP 92 Query: 227 FFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLR 286 ++ +E + + E+ ++ +D + + Y T+E+ I + R Sbjct: 93 TLQLADLWRESGRYDAYGPEMLRI-------ADRHKRELLY-GPTNEEMITEIFRAYIKS 144 Query: 287 PEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIT 346 + LP+ + FR E R G+ R +F + + + + + + + +M Sbjct: 145 YKSLPLNLYHIQWKFRDE----QRPRFGVMRGREFLMKDAYSF-DVDEAGARKSYNKMFV 199 Query: 347 TAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRE 391 + +G+ + +G + S + + A SG + + Sbjct: 200 AYLRTFARMGLKAIPMRAETGPIGGDLSHEFIVLAETGESGVYID 244 >2CIM-A nrPDB Length = 522 Score = 84.5 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 72/433 (16%), Positives = 136/433 (31%), Gaps = 56/433 (12%) Query: 21 ETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESV 80 E Q + + L + ++ + R D + +L+ ++ +G+K K + ES Sbjct: 62 EGQGAKVTEWKLGEDRIELTLQSGRYVRVHDAIFRLRKQLAEALGKKYKIGIRGIEVESF 121 Query: 81 PENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLH 140 V + +L LKV IK + + L+ + +++ + + + Sbjct: 122 IIKVPADHELR-----MLKVPYIKSMENIEGGIQLELEVGEAEMKNRVPDRILTLLEEKI 176 Query: 141 PSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKG-V 199 + + N + W + + M+ ++G+ SRG ++ G Sbjct: 177 EAAQYGAKAEHWNLL---WQREPMEHPFKEDPTQAMMKEGWLKRGS----SRGQWIHGPQ 229 Query: 200 LVFLEQALIQYALRTLGSR-GYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKS 258 + + + L L GY + P + EV + E+Y V + Sbjct: 230 SARIFRTFEKIVLEELLEPLGYREMIFPKLVTWEVWMKSGHAKGVYPEIYYVCPPQTRDP 289 Query: 259 DDNSYDEKYLIATSEQ----------------------PIAALHRDEWLRPEDLPIK-YA 295 D Y T E P E L E++P+K + Sbjct: 290 DYWEEVADYYKVTHEVPTKLIKEKIAEPIGGMCYAQCPPFWMYVAGETLPNEEIPVKVFD 349 Query: 296 GLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQS- 354 T R E G GI RV +F +IE + + EE+ + Sbjct: 350 RSGTSHRYESGG----IHGIERVDEFHRIEIVWIG--TKEEVLKCAEELHDRYMHIFNDI 403 Query: 355 LGIPYHIVNIVSG------SLNHAASKKL---DLEAWFP---GSGAFRELVSCSNCTDYQ 402 L I + + L A + D EA P G + E + S D Sbjct: 404 LDIEWRKARVTPWFMAQEGLLGLAEENTVGTTDYEACLPYRGPDGEWLEFQNVSINGDKY 463 Query: 403 ARRLRIRYGQTKK 415 + ++ + Sbjct: 464 PKGFNVKLQSGDE 476 >1QF6-A nrPDB Length = 642 Score = 64.4 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 33/205 (16%), Positives = 70/205 (34%), Gaps = 20/205 (9%) Query: 163 TVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIP 222 K H + +D + ++ G + G +F E L + L Y Sbjct: 237 EEAAKRDHRKIGKQLDLYHMQE--EAPGMVFWHNDGWTIFRE--LEVFVRSKLKEYQYQE 292 Query: 223 IYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRD 282 + PF M + + ++ + + ++ + E Y I P + Sbjct: 293 VKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENRE----------YCIKPMNCPGHVQIFN 342 Query: 283 EWLR-PEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMF 341 + L+ DLP++ A +C R E G+ RV F + + ++ + + + Sbjct: 343 QGLKSYRDLPLRMAEFGSCHRNEPSGS---LHGLMRVRGFTQDDAHIFC--TEEQIRDEV 397 Query: 342 EEMITTAEEFYQSLGIPYHIVNIVS 366 I + Y + G +V + + Sbjct: 398 NGCIRLVYDMYSTFGFEKIVVKLST 422 >4HWO-A nrPDB Length = 411 Score = 62.5 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 69/200 (34%), Gaps = 20/200 (10%) Query: 168 YSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPF 227 H + +D + ++ G + G +F E L + L Y + PF Sbjct: 3 RDHRKIGKQLDLYHMQE--EAPGMVFWHNDGWTIFRE--LEVFVRSKLKEYQYQEVKGPF 58 Query: 228 FMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLR- 286 M + + ++ + + ++ + E Y I P ++ L+ Sbjct: 59 MMDRVLWEKTGHWDNYKDAMFTTSSENRE----------YCIKPMNCPGHVQIFNQGLKS 108 Query: 287 PEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMIT 346 DLP++ A +C R E G+ RV F + + ++ + + + I Sbjct: 109 YRDLPLRMAEFGSCHRNEPSGS---LHGLMRVRGFTQDDAHIFC--TEEQIRDEVNGCIR 163 Query: 347 TAEEFYQSLGIPYHIVNIVS 366 + Y + G +V + + Sbjct: 164 LVYDMYSTFGFEKIVVKLST 183 >5Z5E-A nrPDB Length = 534 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 45/261 (17%), Positives = 95/261 (36%), Gaps = 40/261 (15%) Query: 223 IYTPFFMRKEVMQEVAQLSQFDEELY-KVIGKGSEKSDDNSYDEKYLIA-TSEQPIAALH 280 + P ++ + + + L E + + I E+ +E YL T++ P Sbjct: 158 LMFPIYIGPDSQEALNLLKNLKENVSEQYIKDIIERVKKMVENEAYLRPETAQGPYVMFK 217 Query: 281 RDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSW-- 338 R+ L + LP+ A + FR E+ + + R+ +F + E ++ P DN+ Sbjct: 218 REFILHRQKLPLGLAVVGKAFRNEIS----PRQLLLRLREFTQAELQIFFDPEDNEFDIN 273 Query: 339 ---------------------------EMFEEMITTAEEFYQSLGIP---YHIVNIVSGS 368 E + + ++FY+ LGIP + Sbjct: 274 EVKDVELNFLDKEGNYKRIKVKDLPFPEFYAYFVGKVKQFYERLGIPEERLRFRELSEKE 333 Query: 369 LNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQ-ARRLRIRYGQTKKMMDKVEFVHMLN 427 +D+E FP G ++E+ TD+ + +++ D +F+ + Sbjct: 334 KAFYNKYHVDIEINFPTYG-WKEVGGIHYRTDHDLSGHMKVSGKDLTVQKDNKKFIPHVL 392 Query: 428 ATMCATTRTICAILENYQTEK 448 R + A+++ + TE+ Sbjct: 393 ELSFGVDRNVLALIDLFLTEE 413 Score = 32.5 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 32/84 (38%), Gaps = 5/84 (5%) Query: 209 QYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYL 268 Y LR + + + M KEV L F++ + + ++D ++ + Sbjct: 67 NYFLRLHPN--FWEVDPAIVMPKEVFIASGHLENFNDPIVECKNGHRFRADHLIEEKLNI 124 Query: 269 IATSEQPIAALHRDEWLRPEDLPI 292 A + ++ +E L+ PI Sbjct: 125 KA---EGLSLSEMEELLKNVRCPI 145 >1NYR-A nrPDB Length = 645 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 77/233 (33%), Gaps = 23/233 (9%) Query: 163 TVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIP 222 RK+ H + ++ F + + G+ + + + +Y + S GY Sbjct: 236 EERKERDHRKIGKELELFTN---SQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDH 292 Query: 223 IYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRD 282 +YTP ++ + + E+++ + + L + ++ + Sbjct: 293 VYTPVLANVDLYKTSGHWDHYQEDMF-------PPMQLDETESMVLRPMNCPHHMMIYAN 345 Query: 283 EWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFE 342 + +LPI+ A L T R E G+ RV + ++ P K E F+ Sbjct: 346 KPHSYRELPIRIAELGTMHRYEASGA---VSGLQRVRGMTLNDSHIFVRPDQIK--EEFK 400 Query: 343 EMITTAEEFYQSLGIP---YHIVNIVSGSLNHAASKKL-DLEAWFPGSGAFRE 391 ++ + Y+ G + + K D + W +E Sbjct: 401 RVVNMIIDVYKDFGFEDYSFRLSYRDPEDK----EKYFDDDDMWNKAENMLKE 449 >4YYE-A nrPDB Length = 460 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 48/322 (14%), Positives = 104/322 (32%), Gaps = 86/322 (26%) Query: 193 GYFLKGVLVFLEQALIQYA-LRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVI 251 F + LI++ L+ G+ + TP +K + ++ + ++++KV Sbjct: 56 SMFFLPNGAKIFNKLIEFMKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKV- 114 Query: 252 GKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRD 311 ++ D +E L + + + +LP++++ S R E Sbjct: 115 -----ETTDEEKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLHRNEASGALS- 168 Query: 312 TRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNH 371 G+ R+ +F + + ++ +P KS E + SL + ++IV + Sbjct: 169 --GLTRLRKFHQDDGHIFCTPSQVKS------------EIFNSLKL----IDIVYNKIFP 210 Query: 372 ------AASKKL-------------DLEAW--------------------FPGSGAF--- 389 A DL+ W PG GAF Sbjct: 211 FVKGGSGAESNYFINFSTRPDHFIGDLKVWNHAEQVLKEILEESGKPWKLNPGDGAFYGP 270 Query: 390 ----------RELVSCSNC-TDYQ-ARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTI 437 R+ + D+Q R +++ + +H AT + R + Sbjct: 271 KLDIMVTDHLRKTHQVATIQLDFQLPERFDLKFKDQDNSYKRPIMIHR--ATFGSIERFM 328 Query: 438 CAILENYQTEKGITVPEKLKEF 459 ++++ + P L + Sbjct: 329 ALLIDSNEG----RWPFWLNPY 346 >4P3N-A nrPDB Length = 415 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 42/291 (14%), Positives = 84/291 (28%), Gaps = 57/291 (19%) Query: 190 GSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYK 249 GS + KG ++ ALI++ RG+ + TP + + E ++ Sbjct: 33 GSCFFLPKG--AYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFS 90 Query: 250 VIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHG 309 + + + + + +LP++ A R E+ Sbjct: 91 FEVEKELFALKPMNCPGHCL---------MFDHRPRSWRELPLRLADFGVLHRNELSGA- 140 Query: 310 RDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSL 369 G+ RV +F++ + ++ + + + + Y G + + Sbjct: 141 --LTGLTRVRRFQQDDAHIFC--AMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEK 196 Query: 370 NHAASKKLDLEAWFPGS-------GAFRE-----------------------LVSCSNC- 398 D+E W F E + C Sbjct: 197 FLG-----DIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCA 251 Query: 399 ---TDYQAR-RLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQ 445 D+Q R + Y + DK V + A + + R I + ENY Sbjct: 252 TIQLDFQLPIRFNLTY-VSHDGDDKKRPVIVHRAILGSVERMIAILTENYG 301 >1B76-A nrPDB Length = 442 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 91/249 (36%), Gaps = 37/249 (14%) Query: 267 YLIATSEQPIAALHRDEW-LRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIE 325 YL + Q I ++ L A + FR E+ IFRV +FE++E Sbjct: 121 YLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEI----TPRNFIFRVREFEQME 176 Query: 326 QFVYSSPHDNKSWEMFEEMITTAEEFYQSLGI------PYHIVNIVSGSLNHAASKKLDL 379 + P +++ W + +++Q +G+ PY S H A +D+ Sbjct: 177 IEYFVRPGEDEYW--HRYWVEERLKWWQEMGLSRENLVPY---QQPPESSAHYAKATVDI 231 Query: 380 EAWFPGSGAFRELVS-------CSNCTDYQARRLRIRYGQTKKMMDKVEF---------- 422 FP E ++ S+ D +A + R + + ++ + Sbjct: 232 LYRFPHGSLELEGIAQRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFV 291 Query: 423 VHMLNATMCATTRTICAILENYQTEK----GITVPEKLKEFMPPGLQELIPFVKPAPIEQ 478 +++ + + + E + E+ + KLK + P +IP VK P Sbjct: 292 PYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEIT 351 Query: 479 EPSKKQKKQ 487 E +K+ K + Sbjct: 352 EYAKRLKAR 360 >1ATI-A nrPDB Length = 505 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 47/249 (18%), Positives = 91/249 (36%), Gaps = 37/249 (14%) Query: 267 YLIATSEQPIAALHRDEW-LRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIE 325 YL + Q I ++ L A + FR E+ IFRV +FE++E Sbjct: 184 YLRPETAQGIFVNFKNVLDATSRKLGFGIAQIGKAFRNEI----TPRNFIFRVREFEQME 239 Query: 326 QFVYSSPHDNKSWEMFEEMITTAEEFYQSLGI------PYHIVNIVSGSLNHAASKKLDL 379 + P +++ W + +++Q +G+ PY S H A +D+ Sbjct: 240 IEYFVRPGEDEYW--HRYWVEERLKWWQEMGLSRENLVPY---QQPPESSAHYAKATVDI 294 Query: 380 EAWFPGSGAFRELVS-------CSNCTDYQARRLRIRYGQTKKMMDKVEF---------- 422 FP E ++ S+ D +A + R + + ++ + Sbjct: 295 LYRFPHGSLELEGIAQRTDFDLGSHTKDQEALGITARVLRNEHSTQRLAYRDPETGKWFV 354 Query: 423 VHMLNATMCATTRTICAILENYQTEK----GITVPEKLKEFMPPGLQELIPFVKPAPIEQ 478 +++ + + + E + E+ + KLK + P +IP VK P Sbjct: 355 PYVIEPSAGVDRGVLALLAEAFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEIT 414 Query: 479 EPSKKQKKQ 487 E +K+ K + Sbjct: 415 EYAKRLKAR 423 >3A31-A nrPDB Length = 471 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 58/172 (33%), Gaps = 21/172 (12%) Query: 189 AGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELY 248 AG + L G + AL + + RGY + TP E+ + + + +Y Sbjct: 39 AGVPLFSLGGGPIRY--ALAEVLAKFHARRGYYVVETPIIASTELFKVSGHIEFYRNNMY 96 Query: 249 KVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPED---LPIKYAGLSTCFRQEV 305 +G E + +++ L +E + LP K R E Sbjct: 97 LFDIEGHEFAVKPMNCPYHIL---------LFLNEVAKHRSKLPLPFKVFEFGRVHRYEP 147 Query: 306 GSHGRDTRGIFRVHQFEKIEQFVYSSPH---DNKSWEMFEEMITTAEEFYQS 354 G+ RV F + + P + +++FEEM E ++ Sbjct: 148 SGS---IYGLLRVRGFTQ-DDAHIIVPGGRVIDVVYDVFEEMKLVLERLFKL 195 >3VQX-A nrPDB Length = 291 Score = 45.2 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 30/157 (19%), Positives = 54/157 (34%), Gaps = 26/157 (16%) Query: 207 LIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEK 266 L + R RG++ I +P + E ++ + + D+ Sbjct: 83 LEREITRFFVDRGFLEIKSPILIPLEYIERMG-----------IDNDTELSKQIFRVDKN 131 Query: 267 YLIATSEQP-IAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIE 325 + + P + R D PIK + C+R+E S G++ E+ Sbjct: 132 FCLRPMLAPNLYNYLRKLDRALPD-PIKIFEIGPCYRKE--SDGKE--------HLEEFT 180 Query: 326 QFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIV 362 + + E E +IT +F LGI + IV Sbjct: 181 MLNFCQMGSGCTRENLESIIT---DFLNHLGIDFKIV 214 >2PME-A nrPDB Length = 693 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 5/71 (7%) Query: 265 EKYLIA-TSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEK 323 YL T++ R LP A + FR E+ G+ RV +F Sbjct: 239 PGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEIS----PRSGLIRVREFTM 294 Query: 324 IEQFVYSSPHD 334 E + P + Sbjct: 295 AEIEHFVDPSE 305 >6JP2-A nrPDB Length = 278 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 64/164 (39%), Gaps = 21/164 (12%) Query: 150 DVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQ---- 205 D + R +G+ T +K + + D ++ +V + +KG++ + Sbjct: 10 DAQIQRLREYGNGTYEQKV--FEDLASRDAAFSKEMSVASTDNEKKIKGMIANPSRHGLT 67 Query: 206 ALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFD--EELYKVIGKGSEKSDDNSY 263 L+ L + G+I + TP F+ K+ + + ++++ + D+ Sbjct: 68 QLMNDIADALVAEGFIEVRTPIFISKDALARMTITEDKPLFKQVFWI--------DEKRA 119 Query: 264 DEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGS 307 L + ++ RD D P+K + +CFR+E S Sbjct: 120 LRPMLAPN----LYSVMRDLR-DHTDGPVKIFEMGSCFRKESHS 158 >1QE0-A nrPDB Length = 420 Score = 35.6 bits (80), Expect = 0.057, Method: Composition-based stats. Identities = 42/196 (21%), Positives = 65/196 (33%), Gaps = 30/196 (15%) Query: 213 RTLGSRGYIPIYTPFFMRKEVMQ-EVAQLSQF-DEELYKVIGKGSEKSDDNSYDEKYLIA 270 + Y I TP F ++ V + +E+Y KG Sbjct: 28 ELMTFYNYKEIRTPIFESTDLFARGVGDSTDVVQKEMYTFKDKGDRSITLRPE------G 81 Query: 271 TSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEK--IEQFV 328 T+ + + P PIK FR E G R QF + +E Sbjct: 82 TAAVVRSYIEHKMQGNPNQ-PIKLYYNGPMFRYERKQKG-------RYRQFNQFGVEAIG 133 Query: 329 YSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGA 388 +P + E++ YQS G+ + + +V S+ AS+K EA Sbjct: 134 AENPSVDA------EVLAMVMHIYQSFGLKH--LKLVINSVGDMASRKEYNEALV----K 181 Query: 389 FRELVSCSNCTDYQAR 404 E V C+D Q+R Sbjct: 182 HFEPVIHEFCSDCQSR 197 >4YCV-A nrPDB Length = 516 Score = 34.8 bits (78), Expect = 0.096, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 48/151 (31%), Gaps = 41/151 (27%) Query: 207 LIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEK 266 +I + L RG+ + TP ++ A F + + + Sbjct: 182 IINFLRNFLNERGFFEVETPMM---NLIAGGANARPF------ITHHN------DLDLDL 226 Query: 267 YLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVH--QFEKI 324 YL +E P+ L K + FR E GI H +F Sbjct: 227 YLRIATELPLKMLIVGGID-------KVYEIGKVFRNE---------GIDNTHNPEFTSC 270 Query: 325 EQFVYSSPHDNKSWEMFEEMITTAEEFYQSL 355 E + ++ + ++I +E+F+ L Sbjct: 271 EFYW--------AYADYNDLIKWSEDFFSQL 293 >2ZNJ-A nrPDB Length = 308 Score = 32.9 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 52/132 (39%), Gaps = 23/132 (17%) Query: 215 LGSRGYIPIYTPFFMRKEVMQEVAQLSQFD--EELYKVIGKGSEKSDDNSYDEKYLIATS 272 L +G++ + TP + K + ++ +++ + GK K L Sbjct: 104 LHQQGFVQVVTPTIITKSALAKMTIGEDHPLFSQVFWLDGK------------KCLRPML 151 Query: 273 EQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSP 332 + L R E R D PI+ + TC+R+E ++G +++F + +P Sbjct: 152 APNLYTLWR-ELERLWDKPIRIFEIGTCYRKE-------SQGAQHLNEFTMLNLTELGTP 203 Query: 333 HDNKSWEMFEEM 344 + + E+M Sbjct: 204 LEERHQR-LEDM 214 >1SDJ-A nrPDB Length = 310 Score = 32.5 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 69/213 (32%), Gaps = 11/213 (5%) Query: 210 YALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLI 269 Y + S+ + + + E AQ+ EL SDD+ +Y Sbjct: 17 YHVDAFTSQPFRGNSAGVVFPADNLSE-AQMQLIARELGHSETAFLLHSDDSDVRIRYFT 75 Query: 270 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKI--EQF 327 T E PI + + K GL C + G+ I + + +I EQ Sbjct: 76 PTVEVPICGHA---TVAAHYVRAKVLGLGNCTIWQTSLAGKHRVTIEKHNDDYRISLEQG 132 Query: 328 --VYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPG 385 + P + ++ + E+ G+P + + ++D++A P Sbjct: 133 TPGFEPPLEGETRAAIINALHLTEDDI-LPGLPIQVATTGHSKVMIPLKPEVDIDALSPD 191 Query: 386 SGAFRELVSCSNCTDYQARRLRIRYGQTKKMMD 418 A + C + +IR G+ + Sbjct: 192 LNALTAISKKIGCNGFFP--FQIRPGKNETDGR 222 >6AVE-A nrPDB Length = 527 Score = 32.1 bits (71), Expect = 0.61, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 40/118 (33%), Gaps = 19/118 (16%) Query: 232 EVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLP 291 E++Q+ A F + + + E D +D + E ++ R E PED Sbjct: 137 EILQDKANFRNFKPKPFNM----LEFYDRAGHDIR------EMLLSCFFRGEQCSPEDFK 186 Query: 292 IKYAGLSTCFRQEVGSHGRDTR---------GIFRVHQFEKIEQFVYSSPHDNKSWEM 340 + + C+ G G+ G+ + ++ E D S+E Sbjct: 187 VVFTRYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEA 244 >3IJ4-A nrPDB Length = 465 Score = 32.1 bits (71), Expect = 0.61, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 40/118 (33%), Gaps = 19/118 (16%) Query: 232 EVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLP 291 E++Q+ A F + + + E D +D + E ++ R E PED Sbjct: 136 EILQDKANFRNFKPKPFNM----LEFYDRAGHDIR------EMLLSCFFRGEQCSPEDFK 185 Query: 292 IKYAGLSTCFRQEVGSHGRDTR---------GIFRVHQFEKIEQFVYSSPHDNKSWEM 340 + + C+ G G+ G+ + ++ E D S+E Sbjct: 186 VVFTRYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEA 243 >5E6U-A nrPDB Length = 795 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 27/67 (40%), Gaps = 2/67 (2%) Query: 445 QTEKGITVPEKLKEFMPPGLQELIPFVK-PAPIEQEPSKKQKKQHEGSKKKAAARDVTLE 503 Q +G +P L+ + E IPF K PA ++ Q E + + LE Sbjct: 718 QRAQGKDIPPILRPSLHSETWE-IPFEKNPAALQTLFQGPLGAQGEKELQALEKENAQLE 776 Query: 504 NRLQNME 510 LQ +E Sbjct: 777 WELQALE 783 >5J6B-A nrPDB Length = 485 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 14/46 (30%), Positives = 15/46 (32%) Query: 268 LIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTR 313 L S PI AL E L DLP + R D R Sbjct: 184 LKPASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGADLFTTDER 229 >2EQ6-A nrPDB Length = 464 Score = 29.8 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 19/51 (37%), Gaps = 1/51 (1%) Query: 159 WGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQ 209 + K +DL + G+ + + G G LKG V L + + Sbjct: 67 VAEGFGLKAKPELDL-KKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFAR 116 >3QAU-A nrPDB Length = 458 Score = 29.0 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 23/62 (37%) Query: 117 CDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVM 176 + A + L E+ N +PS+ D VE+I G+ Y HVD Sbjct: 155 NPKLAQEKIASKKAELLELANQAYPSIVKRGGGARDLHVEQIKGEPDFLVVYIHVDTQEA 214 Query: 177 VD 178 + Sbjct: 215 MG 216 >4YLS-A nrPDB Length = 487 Score = 28.6 bits (62), Expect = 7.1, Method: Composition-based stats. Identities = 10/68 (14%), Positives = 30/68 (44%) Query: 5 LDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTI 64 L++ DK + A + ++R + +L+ S+W + R + + + + Sbjct: 347 LNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQRHQLERRKEELKERLAQV 406 Query: 65 GEKMKKKE 72 +++ ++E Sbjct: 407 RKQISREE 414 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.122 0.299 Lambda K H 0.267 0.0370 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,871,950 Number of Sequences: 36641 Number of extensions: 641147 Number of successful extensions: 2255 Number of sequences better than 10.0: 57 Number of HSP's better than 10.0 without gapping: 56 Number of HSP's successfully gapped in prelim test: 37 Number of HSP's that attempted gapping in prelim test: 2035 Number of HSP's gapped (non-prelim): 100 length of query: 514 length of database: 10,336,785 effective HSP length: 101 effective length of query: 413 effective length of database: 6,636,044 effective search space: 2740686172 effective search space used: 2740686172 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.3 bits)